Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002652-TA|BGIBMGA002652-PA|IPR009053|Prefoldin,
IPR010989|t-snare, IPR003900|RepA / Rep+ protein KID
(1982 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U31906-1|AAC51791.1| 2083|Homo sapiens golgin-245 protein. 126 8e-28
D10667-1|BAA36971.1| 1052|Homo sapiens smooth muscle myosin heav... 113 5e-24
BC104906-1|AAI04907.1| 1938|Homo sapiens myosin, heavy chain 11,... 113 5e-24
BC101677-1|AAI01678.1| 1938|Homo sapiens myosin, heavy chain 11,... 113 5e-24
AY520817-1|AAS98911.1| 1945|Homo sapiens smooth muscle myosin he... 113 5e-24
AY520816-1|AAS98910.1| 1979|Homo sapiens smooth muscle myosin he... 113 5e-24
AF001548-1|AAC31665.1| 1857|Homo sapiens Myosin heavy chain (MHY... 113 5e-24
AB020673-1|BAA74889.2| 1984|Homo sapiens KIAA0866 protein protein. 113 5e-24
M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein. 113 8e-24
BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,... 113 8e-24
AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein p... 113 8e-24
BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,... 112 1e-23
Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9, no... 108 2e-22
CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein. 108 2e-22
AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy... 108 2e-22
Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heav... 105 1e-21
X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain (... 105 2e-21
BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6, ... 104 3e-21
D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heav... 104 4e-21
X82834-1|CAA58041.1| 2185|Homo sapiens 256 kD golgin protein. 103 6e-21
U41740-1|AAC50434.1| 2230|Homo sapiens trans-Golgi p230 protein. 103 6e-21
M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle... 103 9e-21
EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7, ... 99 8e-20
BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7, ... 99 8e-20
BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7, ... 99 8e-20
AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antige... 99 8e-20
AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypepti... 99 8e-20
M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain p... 100 1e-19
M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain p... 100 1e-19
Z15005-1|CAA78727.1| 2663|Homo sapiens CENP-E protein. 99 1e-19
X69292-1|CAA49154.1| 881|Homo sapiens smooth muscle mysosin he... 99 1e-19
AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain... 99 1e-19
AC012487-1|AAX88838.1| 1583|Homo sapiens unknown protein. 99 1e-19
AB209996-1|BAE06078.1| 2585|Homo sapiens CENPE variant protein p... 99 1e-19
AB002334-1|BAA20794.2| 1635|Homo sapiens KIAA0336 protein. 99 2e-19
BC132736-1|AAI32737.1| 1843|Homo sapiens KIAA1212 protein. 97 6e-19
AB201172-1|BAE44387.1| 1870|Homo sapiens girdin protein. 97 6e-19
AB125644-1|BAF44475.1| 1843|Homo sapiens PKB/Akt-binding protein... 97 6e-19
X78998-1|CAA55632.1| 1411|Homo sapiens endosomal protein protein. 96 1e-18
Z38133-1|CAA86293.1| 1937|Homo sapiens Myosin protein. 96 1e-18
X15696-1|CAA33731.1| 1085|Homo sapiens protein ( Human muscle mR... 96 1e-18
X51593-1|CAA35942.1| 1085|Homo sapiens embryonic myosin heavy ch... 95 2e-18
X51592-1|CAA35941.1| 1437|Homo sapiens fetal-myosin heavy chain ... 95 2e-18
X13988-1|CAA32167.1| 1940|Homo sapiens protein ( Human mRNA for ... 95 2e-18
X13100-1|CAA31492.1| 1167|Homo sapiens myosin heavy chain (1167 ... 95 2e-18
AB023217-1|BAA76844.2| 1956|Homo sapiens KIAA1000 protein protein. 94 5e-18
X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy... 93 7e-18
AF111783-1|AAD29949.1| 1939|Homo sapiens myosin heavy chain IIb ... 93 7e-18
AF111782-1|AAD29948.1| 1938|Homo sapiens myosin heavy chain prot... 93 1e-17
M36769-1|AAC17185.1| 1937|Homo sapiens perinatal myosin heavy ch... 91 3e-17
BC126409-1|AAI26410.1| 1941|Homo sapiens myosin, heavy chain 2, ... 91 4e-17
AF111784-1|AAD29950.1| 1941|Homo sapiens myosin heavy chain IIa ... 91 4e-17
L40157-1|AAA79121.1| 1410|Homo sapiens endosome-associated prote... 91 5e-17
BC114545-1|AAI14546.1| 1939|Homo sapiens myosin, heavy chain 1, ... 91 5e-17
AF111785-1|AAD29951.1| 1939|Homo sapiens myosin heavy chain IIx/... 90 9e-17
X03740-1|CAA27380.1| 876|Homo sapiens protein ( Human skeletal ... 85 2e-15
M97501-1|AAA35693.1| 1392|Homo sapiens cytoplasmic linker protei... 85 2e-15
BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with ... 85 2e-15
BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with ... 85 2e-15
AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein. 85 2e-15
AB209693-1|BAD92930.1| 1310|Homo sapiens golgi autoantigen, golg... 85 2e-15
AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein. 85 2e-15
AB209115-1|BAD92352.1| 1065|Homo sapiens restin isoform a varian... 85 3e-15
X64838-1|CAA46050.1| 1427|Homo sapiens restin protein. 84 4e-15
AB111886-1|BAC98374.1| 1571|Homo sapiens KIAA2034 protein protein. 84 4e-15
U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein. 83 7e-15
AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F, 3... 83 7e-15
AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F, 3... 83 7e-15
AF273042-1|AAG34902.1| 685|Homo sapiens CTCL tumor antigen se1-... 83 7e-15
U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protei... 83 1e-14
X75304-1|CAA53052.1| 3259|Homo sapiens giantin protein. 83 1e-14
BC117209-1|AAI17210.1| 1438|Homo sapiens CLIP1 protein protein. 83 1e-14
BC114213-1|AAI14214.1| 1392|Homo sapiens CAP-GLY domain containi... 83 1e-14
AF001691-1|AAC17738.1| 1756|Homo sapiens 195 kDa cornified envel... 83 1e-14
Z54367-1|CAA91196.1| 4684|Homo sapiens plectin protein. 82 2e-14
U63610-1|AAB05428.1| 4574|Homo sapiens plectin protein. 82 2e-14
U53204-1|AAB05427.1| 4574|Homo sapiens plectin protein. 82 2e-14
D25542-1|BAA05025.1| 3225|Homo sapiens golgi antigen gcp372 prot... 82 2e-14
BC126305-1|AAI26306.1| 1438|Homo sapiens CLIP1 protein protein. 82 2e-14
BC007808-1|AAH07808.1| 1006|Homo sapiens MYH7B protein protein. 82 2e-14
AY480051-1|AAR95684.1| 4547|Homo sapiens plectin 11 protein. 82 2e-14
AY480050-1|AAR95683.1| 4551|Homo sapiens plectin 10 protein. 82 2e-14
AY480049-1|AAR95682.1| 4547|Homo sapiens plectin 8 protein. 82 2e-14
AY480048-1|AAR95681.1| 4515|Homo sapiens plectin 7 protein. 82 2e-14
AY480047-1|AAR95680.1| 4684|Homo sapiens plectin 6 protein. 82 2e-14
AY480046-1|AAR95679.1| 4525|Homo sapiens plectin 3 protein. 82 2e-14
AY480045-1|AAR95678.1| 4533|Homo sapiens plectin 2 protein. 82 2e-14
AY480044-1|AAR95677.1| 4574|Homo sapiens plectin 1 protein. 82 2e-14
AL133324-2|CAI19310.2| 1983|Homo sapiens myosin, heavy chain 7B,... 82 2e-14
AL132825-6|CAI43047.2| 1983|Homo sapiens myosin, heavy chain 7B,... 82 2e-14
AB040945-1|BAA96036.2| 2010|Homo sapiens KIAA1512 protein protein. 82 2e-14
BC112391-1|AAI12392.1| 957|Homo sapiens ELKS/RAB6-interacting/C... 81 4e-14
BC111550-1|AAI11551.1| 957|Homo sapiens ERC2 protein protein. 81 4e-14
AB002376-1|BAA20832.2| 970|Homo sapiens KIAA0378 protein. 81 4e-14
AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250... 81 5e-14
U25725-1|AAA86889.1| 1017|Homo sapiens AH antigen protein. 80 7e-14
AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring prot... 80 7e-14
AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associ... 80 7e-14
AB053468-1|BAC54107.1| 992|Homo sapiens ELKS beta protein. 80 7e-14
AB029004-1|BAA83033.2| 1003|Homo sapiens KIAA1081 protein protein. 80 7e-14
AL031058-1|CAA19927.1| 2871|Homo sapiens desmoplakin protein. 80 9e-14
M77830-1|AAA85135.1| 2871|Homo sapiens desmoplakin I protein. 79 1e-13
BX284668-3|CAH70057.1| 1898|Homo sapiens ciliary rootlet coiled-... 79 1e-13
AL365436-2|CAI16590.1| 1203|Homo sapiens cingulin protein. 79 1e-13
AL049569-4|CAI20365.1| 1898|Homo sapiens ciliary rootlet coiled-... 79 1e-13
AF263462-1|AAF74498.1| 1203|Homo sapiens cingulin protein. 79 1e-13
AB037740-1|BAA92557.1| 1208|Homo sapiens KIAA1319 protein protein. 79 1e-13
AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein. 79 2e-13
AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein. 79 2e-13
AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein. 79 2e-13
D86970-1|BAA13206.2| 2067|Homo sapiens KIAA0216 protein. 78 3e-13
BC130453-1|AAI30454.1| 1726|Homo sapiens ANKRD26 protein protein. 78 3e-13
AL162272-4|CAC19649.1| 1710|Homo sapiens novel protein protein. 78 3e-13
AB177858-1|BAD66836.1| 2046|Homo sapiens KIAA0216 splice variant... 78 3e-13
AB053470-1|BAC54109.1| 1088|Homo sapiens ELKS delta protein. 78 3e-13
AB028997-1|BAA83026.2| 1715|Homo sapiens KIAA1074 protein protein. 78 3e-13
BC132784-1|AAI32785.1| 1116|Homo sapiens ELKS/RAB6-interacting/C... 77 5e-13
BC132782-1|AAI32783.1| 1116|Homo sapiens ELKS/RAB6-interacting/C... 77 5e-13
AB053471-1|BAC54110.1| 1116|Homo sapiens ELKS epsilon protein. 77 5e-13
X66397-1|CAA47021.1| 2349|Homo sapiens Tpr protein. 77 6e-13
U69668-1|AAB48030.1| 2363|Homo sapiens Tpr protein. 77 6e-13
BX284668-2|CAH70055.1| 2017|Homo sapiens ciliary rootlet coiled-... 77 6e-13
AL596220-1|CAI13119.1| 2363|Homo sapiens translocated promoter r... 77 6e-13
AL133553-3|CAI17859.1| 2363|Homo sapiens translocated promoter r... 77 6e-13
AL049569-3|CAI20363.1| 2017|Homo sapiens ciliary rootlet coiled-... 77 6e-13
AB007914-1|BAA32290.2| 1919|Homo sapiens KIAA0445 protein protein. 77 6e-13
AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein. 77 9e-13
J05211-1|AAA35766.1| 1752|Homo sapiens protein ( Human desmoplak... 76 1e-12
AK025690-1|BAB15219.1| 746|Homo sapiens protein ( Homo sapiens ... 76 1e-12
AB015617-1|BAA88763.1| 948|Homo sapiens ELKS protein. 76 1e-12
AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and Golgi-l... 76 1e-12
BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein. 75 2e-12
BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein. 75 2e-12
BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein. 75 2e-12
AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein. 75 2e-12
AL137068-5|CAI12358.1| 1773|Homo sapiens centrosomal protein 110... 75 2e-12
AL137068-2|CAM13285.1| 2325|Homo sapiens centrosomal protein 110... 75 2e-12
AK074079-1|BAB84905.1| 1793|Homo sapiens FLJ00150 protein protein. 75 2e-12
AF513978-1|AAP43846.1| 2325|Homo sapiens CENTRIOLIN protein. 75 2e-12
Y12490-1|CAA73095.1| 1979|Homo sapiens Golgi-associated microtub... 75 3e-12
AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome assoc... 75 3e-12
AF007217-1|AAD09135.1| 1978|Homo sapiens Trip230 protein. 75 3e-12
AY703984-1|AAV80770.1| 1581|Homo sapiens SP-A receptor subunit S... 75 3e-12
AF083322-1|AAC32373.1| 994|Homo sapiens centriole associated pr... 75 3e-12
AB177860-1|BAD66838.1| 1715|Homo sapiens KIAA0216 splice variant... 75 3e-12
BC127760-1|AAI27761.1| 658|Homo sapiens Unknown (protein for IM... 73 1e-11
AF273047-1|AAG34907.1| 623|Homo sapiens CTCL tumor antigen se20... 73 1e-11
AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein. 73 1e-11
Z75311-1|CAA99729.1| 1318|Homo sapiens RAD50 homologue hsRAD50 p... 72 2e-11
DQ109808-1|AAZ83370.1| 2479|Homo sapiens nephrocystin-6 protein. 72 2e-11
AY517555-1|AAT44528.1| 941|Homo sapiens hypothetical rhabdomyos... 72 2e-11
AF020091-1|AAB69327.1| 622|Homo sapiens smooth muscle myosin he... 72 2e-11
AF013570-1|AAB69326.1| 588|Homo sapiens smooth muscle myosin he... 72 2e-11
Z22551-1|CAA80271.1| 1356|Homo sapiens 156 kDa Protein protein. 71 3e-11
M21664-1|AAA36344.1| 532|Homo sapiens protein ( Human alpha-myo... 71 3e-11
AY264265-1|AAP20418.1| 1357|Homo sapiens kinectin variant 1 prot... 71 3e-11
AB053469-1|BAC54108.1| 720|Homo sapiens ELKS gamma protein. 71 3e-11
U63139-1|AAB07119.1| 1312|Homo sapiens Rad50 protein. 71 4e-11
AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein. 71 4e-11
AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein pr... 71 4e-11
AF057300-1|AAD50326.1| 1173|Homo sapiens truncated RAD50 protein... 71 4e-11
AF057299-1|AAD50325.1| 1312|Homo sapiens RAD50-2 protein protein. 71 4e-11
BC049849-1|AAH49849.1| 1374|Homo sapiens Unknown (protein for IM... 71 6e-11
AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion prote... 71 6e-11
AY536375-1|AAT66048.1| 820|Homo sapiens rhabdomyosarcoma antige... 71 6e-11
AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein. 71 6e-11
AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein. 71 6e-11
BC039612-1|AAH39612.1| 2002|Homo sapiens MYO18A protein protein. 70 7e-11
AF485338-1|AAL93149.1| 1498|Homo sapiens golgin-160 protein. 70 7e-11
BC078168-1|AAH78168.1| 887|Homo sapiens KIAA1212 protein protein. 70 1e-10
AL157400-6|CAI16830.1| 1820|Homo sapiens M-phase phosphoprotein ... 69 1e-10
AL157389-2|CAI12886.1| 1820|Homo sapiens M-phase phosphoprotein ... 69 1e-10
AB058696-1|BAB47422.1| 1270|Homo sapiens KIAA1793 protein protein. 69 1e-10
BX641024-1|CAE46015.1| 1694|Homo sapiens hypothetical protein pr... 69 2e-10
AL391602-1|CAI12788.3| 1661|Homo sapiens novel protein protein. 69 2e-10
AL132768-4|CAI21460.3| 1661|Homo sapiens novel protein protein. 69 2e-10
AL079335-1|CAI42289.3| 1661|Homo sapiens novel protein protein. 69 2e-10
AB033337-1|BAB69456.1| 1820|Homo sapiens mitotic kinesin-related... 69 2e-10
AB002371-1|BAA20828.2| 1540|Homo sapiens KIAA0373 protein. 69 2e-10
Z11583-1|CAA77669.1| 2115|Homo sapiens NuMA protein protein. 69 2e-10
U53445-1|AAA98972.1| 752|Homo sapiens DOC1 protein. 69 2e-10
AL139421-1|CAI22508.1| 1454|Homo sapiens coiled-coil domain cont... 69 2e-10
AK128577-1|BAC87508.1| 1080|Homo sapiens protein ( Homo sapiens ... 69 2e-10
AB210007-1|BAE06089.1| 2121|Homo sapiens NUMA1 variant protein p... 69 2e-10
Z11584-1|CAA77670.1| 2101|Homo sapiens NuMA protein protein. 68 3e-10
BC133019-1|AAI33020.1| 1427|Homo sapiens LOC650001 protein protein. 68 3e-10
BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 1... 68 3e-10
AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein. 68 3e-10
AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment e... 68 3e-10
AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein. 68 3e-10
AB027133-1|BAB71953.1| 1390|Homo sapiens male enhanced antigen-2... 68 3e-10
D63997-1|BAA23661.1| 1530|Homo sapiens GCP170 protein. 68 4e-10
BC013023-1|AAH13023.1| 1193|Homo sapiens NUMA1 protein protein. 68 4e-10
AL139421-4|CAI22511.1| 720|Homo sapiens coiled-coil domain cont... 68 4e-10
AL139421-3|CAI22510.1| 1044|Homo sapiens coiled-coil domain cont... 68 4e-10
BX538286-1|CAD98081.1| 724|Homo sapiens hypothetical protein pr... 67 5e-10
BX537985-1|CAD97945.1| 1202|Homo sapiens hypothetical protein pr... 67 7e-10
BC126266-1|AAI26267.1| 976|Homo sapiens synaptonemal complex pr... 67 7e-10
BC027860-1|AAH27860.1| 893|Homo sapiens filamin A interacting p... 67 7e-10
AY642382-1|AAV34207.1| 1135|Homo sapiens GPBP-interacting protei... 67 7e-10
AL645502-1|CAH70064.1| 976|Homo sapiens synaptonemal complex pr... 67 7e-10
AL358372-3|CAH72848.1| 792|Homo sapiens synaptonemal complex pr... 67 7e-10
AL358372-2|CAH72847.1| 976|Homo sapiens synaptonemal complex pr... 67 7e-10
AF514869-1|AAQ08179.1| 1133|Homo sapiens GPBP-interacting protei... 67 7e-10
AF514868-1|AAQ08178.1| 1133|Homo sapiens GPBP-interacting protei... 67 7e-10
AF514867-1|AAQ08177.1| 1135|Homo sapiens GPBP-interacting protei... 67 7e-10
AF329092-1|AAN16206.1| 764|Homo sapiens GPBP-interacting protei... 67 7e-10
AF273043-1|AAG34903.1| 795|Homo sapiens CTCL tumor antigen se2-... 67 7e-10
AB208841-1|BAD92078.1| 1585|Homo sapiens Nuclear mitotic apparat... 67 7e-10
BC131805-1|AAI31806.1| 913|Homo sapiens CCDC46 protein protein. 66 9e-10
AK126045-1|BAC86410.1| 978|Homo sapiens galactosaminyltransfera... 66 9e-10
X03741-1|CAA27381.1| 635|Homo sapiens protein ( Human cardiac m... 66 1e-09
M81105-1|AAA59888.1| 1337|Homo sapiens cellular myosin heavy cha... 66 1e-09
D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein. 66 1e-09
BC080545-1|AAH80545.1| 498|Homo sapiens MYH11 protein protein. 66 1e-09
AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein. 66 1e-09
X95654-1|CAA64956.1| 976|Homo sapiens polypeptide of 976 aa pro... 66 2e-09
BC109126-1|AAI09127.1| 872|Homo sapiens chromosome 10 open read... 65 2e-09
BC043398-1|AAH43398.1| 805|Homo sapiens CEP290 protein protein. 65 2e-09
BC036225-1|AAH36225.1| 872|Homo sapiens chromosome 10 open read... 65 2e-09
AY257469-1|AAP13528.1| 2027|Homo sapiens rho/rac-interacting cit... 65 2e-09
AL355378-1|CAI15667.1| 872|Homo sapiens novel protein protein. 65 2e-09
AL162742-5|CAI12110.1| 872|Homo sapiens novel protein protein. 65 2e-09
AL157400-5|CAI16831.1| 1780|Homo sapiens M-phase phosphoprotein ... 65 2e-09
AL157389-3|CAI12887.1| 1780|Homo sapiens M-phase phosphoprotein ... 65 2e-09
AK093227-1|BAC04102.1| 550|Homo sapiens protein ( Homo sapiens ... 65 2e-09
BC126123-1|AAI26124.1| 1093|Homo sapiens TATA element modulatory... 65 3e-09
BC117418-1|AAI17419.1| 1093|Homo sapiens TATA element modulatory... 65 3e-09
AK025632-1|BAB15196.1| 720|Homo sapiens protein ( Homo sapiens ... 65 3e-09
AB209109-1|BAD92346.1| 1096|Homo sapiens TATA element modulatory... 65 3e-09
M25139-1|AAA60385.1| 611|Homo sapiens myosin heavy chain beta-s... 64 4e-09
L01042-1|AAD54608.1| 1093|Homo sapiens TATA element modulatory f... 64 4e-09
DQ139275-1|ABA43896.1| 1313|Homo sapiens Tax1-binding protein 2 ... 64 4e-09
BC000280-1|AAH00280.1| 471|Homo sapiens MYH10 protein protein. 64 4e-09
AK125925-1|BAC86346.1| 623|Homo sapiens protein ( Homo sapiens ... 64 4e-09
AF112218-1|AAF17206.1| 742|Homo sapiens unknown protein. 64 4e-09
AY282407-1|AAP40331.1| 1116|Homo sapiens M-phase phosphoprotein ... 64 5e-09
AL590431-12|CAH71270.1| 242|Homo sapiens tropomyosin 3 protein. 64 5e-09
AL589986-1|CAH70024.1| 1943|Homo sapiens trichohyalin protein. 64 5e-09
AK092690-1|BAC03946.1| 243|Homo sapiens protein ( Homo sapiens ... 64 5e-09
BC111801-1|AAI11802.1| 703|Homo sapiens ROCK2 protein protein. 64 6e-09
AB040942-1|BAA96033.1| 1326|Homo sapiens KIAA1509 protein protein. 64 6e-09
U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-co... 63 9e-09
BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated, coiled-... 63 9e-09
AY354204-1|AAQ63889.2| 972|Homo sapiens retinoic acid induced 1... 63 9e-09
AK022532-1|BAB14081.1| 975|Homo sapiens protein ( Homo sapiens ... 63 1e-08
AB018345-1|BAA34522.2| 1578|Homo sapiens KIAA0802 protein protein. 63 1e-08
AL132765-6|CAC10587.1| 977|Homo sapiens ribosome binding protei... 62 1e-08
AL132765-4|CAH74034.1| 1410|Homo sapiens ribosome binding protei... 62 1e-08
AK025336-1|BAB15114.1| 963|Homo sapiens protein ( Homo sapiens ... 62 1e-08
AB208965-1|BAD92202.1| 705|Homo sapiens Rho-associated, coiled-... 62 1e-08
AB023166-1|BAA76793.2| 1559|Homo sapiens KIAA0949 protein protein. 62 1e-08
BC128578-1|AAI28579.1| 751|Homo sapiens RRBP1 protein protein. 62 2e-08
AB095935-1|BAC23111.1| 996|Homo sapiens KIAA2015 protein protein. 62 2e-08
BC128577-1|AAI28578.1| 934|Homo sapiens RRBP1 protein protein. 62 3e-08
BC117132-1|AAI17133.1| 1306|Homo sapiens kinectin 1 (kinesin rec... 62 3e-08
BC114620-1|AAI14621.1| 1756|Homo sapiens periplakin protein. 62 3e-08
BC112337-1|AAI12338.1| 1306|Homo sapiens kinectin 1 (kinesin rec... 62 3e-08
AK223258-1|BAD96978.1| 284|Homo sapiens tropomyosin 2 (beta) is... 62 3e-08
AK131080-1|BAC85130.1| 563|Homo sapiens FLJ00279 protein protein. 62 3e-08
AK126630-1|BAC86621.1| 1016|Homo sapiens protein ( Homo sapiens ... 62 3e-08
AK027863-1|BAB55415.1| 612|Homo sapiens protein ( Homo sapiens ... 62 3e-08
AF041004-1|AAD17459.1| 1756|Homo sapiens periplakin protein. 62 3e-08
AF013717-1|AAC39668.1| 1756|Homo sapiens periplakin protein. 62 3e-08
AF006751-1|AAC25977.1| 977|Homo sapiens ES/130 protein. 62 3e-08
AB046785-1|BAB13391.2| 1313|Homo sapiens KIAA1565 protein protein. 62 3e-08
AB037819-1|BAA92636.2| 1586|Homo sapiens KIAA1398 protein protein. 62 3e-08
AB011140-1|BAA25494.1| 1426|Homo sapiens KIAA0568 protein protein. 62 3e-08
X06976-1|CAA30039.1| 543|Homo sapiens beta myosin heavy chain (... 61 3e-08
M21665-1|AAA36345.1| 524|Homo sapiens protein ( Human beta-myos... 61 3e-08
M17712-1|AAA36343.1| 543|Homo sapiens protein ( Human cardiac m... 61 3e-08
D64159-1|BAA21515.1| 709|Homo sapiens 3-7 gene product protein. 61 3e-08
AL832010-1|CAD89917.1| 973|Homo sapiens hypothetical protein pr... 61 3e-08
M75165-1|AAB59509.1| 284|Homo sapiens tropomyosin protein. 61 5e-08
M74817-1|AAA61230.1| 284|Homo sapiens tropomyosin-1 protein. 61 5e-08
M25142-1|AAA60387.1| 389|Homo sapiens myosin heavy chain alpha-... 61 5e-08
M12125-1|AAA36773.1| 284|Homo sapiens protein ( Human fibroblas... 61 5e-08
L25616-1|AAB65853.1| 1300|Homo sapiens kinectin protein. 61 5e-08
D86326-1|BAA25300.1| 962|Homo sapiens p115 protein. 61 5e-08
D13629-1|BAA02794.2| 1307|Homo sapiens KIAA0004 protein. 61 5e-08
BC032654-1|AAH32654.1| 961|Homo sapiens vesicle docking protein... 61 5e-08
BC011776-1|AAH11776.1| 284|Homo sapiens tropomyosin 2 (beta) pr... 61 5e-08
AL133410-2|CAI10974.1| 284|Homo sapiens tropomyosin 2 (beta) pr... 61 5e-08
BC108904-1|AAI08905.1| 725|Homo sapiens hyaluronan-mediated mot... 60 6e-08
BC069268-1|AAH69268.1| 990|Homo sapiens golgi autoantigen, golg... 60 6e-08
AL590708-22|CAI13842.1| 952|Homo sapiens golgi autoantigen, gol... 60 6e-08
AL590708-21|CAI13841.1| 990|Homo sapiens golgi autoantigen, gol... 60 6e-08
AL138742-1|CAI22698.1| 1325|Homo sapiens KIAA1009 protein. 60 6e-08
AF248953-1|AAF65550.1| 990|Homo sapiens golgi matrix protein GM... 60 6e-08
AB023226-1|BAA76853.2| 1345|Homo sapiens KIAA1009 protein protein. 60 6e-08
CR533567-1|CAG38598.1| 691|Homo sapiens KIAA1536 protein. 60 8e-08
BC003177-1|AAH03177.1| 691|Homo sapiens calcium binding and coi... 60 8e-08
AY563137-1|AAT68474.1| 691|Homo sapiens calphoglin protein. 60 8e-08
AY358397-1|AAQ88763.1| 691|Homo sapiens EESP2436 protein. 60 8e-08
AY211909-1|AAO65163.1| 309|Homo sapiens sarcoma antigen NY-SAR-... 60 8e-08
AL591543-1|CAI17285.1| 992|Homo sapiens ankyrin repeat domain 1... 60 8e-08
AK027881-1|BAB55428.1| 690|Homo sapiens protein ( Homo sapiens ... 60 8e-08
AB040969-1|BAA96060.1| 645|Homo sapiens KIAA1536 protein protein. 60 8e-08
U93121-1|AAB88727.1| 753|Homo sapiens M-phase phosphoprotein-1 ... 60 1e-07
M63618-1|AAA35606.1| 2095|Homo sapiens bullous pemphigoid antige... 60 1e-07
L11690-1|AAA52288.1| 2649|Homo sapiens bullous pemphigoid antige... 60 1e-07
BC126912-1|AAI26913.1| 1132|Homo sapiens CROCC protein protein. 60 1e-07
BC126911-1|AAI26912.1| 1132|Homo sapiens CROCC protein protein. 60 1e-07
AY739715-1|AAW65984.1| 617|Homo sapiens M-phase phosphoprotein ... 60 1e-07
AL133410-1|CAI10975.1| 284|Homo sapiens tropomyosin 2 (beta) pr... 60 1e-07
AL096710-6|CAI22047.1| 2649|Homo sapiens dystonin protein. 60 1e-07
M19713-1|AAA61225.1| 284|Homo sapiens TPM1 protein. 59 1e-07
AY014284-1|AAK27309.1| 699|Homo sapiens nucleoporin NYD-SP7 pro... 59 1e-07
AK131528-1|BAD18666.1| 1586|Homo sapiens protein ( Homo sapiens ... 59 1e-07
M19714-1|AAA61226.1| 264|Homo sapiens TPM1 protein. 59 2e-07
BC008345-1|AAH08345.1| 963|Homo sapiens Unknown (protein for IM... 59 2e-07
AY736182-1|AAU86898.1| 1989|Homo sapiens ninein isoform 6 protein. 59 2e-07
AY640415-1|AAT68295.1| 284|Homo sapiens tropomyosin alpha stria... 59 2e-07
AF302773-1|AAG33512.2| 2090|Homo sapiens ninein-Lm isoform protein. 59 2e-07
X03445-1|CAA27174.1| 572|Homo sapiens protein ( Human mRNA for ... 58 2e-07
X03444-1|CAA27173.1| 702|Homo sapiens protein ( Human mRNA for ... 58 2e-07
S67240-1|AAB28951.1| 330|Homo sapiens smooth muscle myosin heav... 58 2e-07
M13451-1|AAA36164.1| 572|Homo sapiens protein ( Human lamin C m... 58 2e-07
BC086869-1|AAH86869.1| 954|Homo sapiens FLJ25770 protein protein. 58 2e-07
BC014507-1|AAH14507.1| 664|Homo sapiens lamin A/C protein. 58 2e-07
BC003162-1|AAH03162.1| 572|Homo sapiens lamin A/C protein. 58 2e-07
BC000511-1|AAH00511.1| 572|Homo sapiens lamin A/C protein. 58 2e-07
AY847597-1|AAW32540.1| 664|Homo sapiens lamin A/C transcript va... 58 2e-07
AY847596-1|AAW32539.1| 480|Homo sapiens lamin A/C transcript va... 58 2e-07
AY681966-1|AAV87216.1| 2069|Homo sapiens citron protein. 58 2e-07
AY528714-1|ABB04050.1| 487|Homo sapiens rhabdomyosarcoma antige... 58 2e-07
AY357727-1|AAR29466.1| 614|Homo sapiens progerin protein. 58 2e-07
AL135927-4|CAI15523.1| 614|Homo sapiens lamin A/C protein. 58 2e-07
AL135927-3|CAI15522.1| 664|Homo sapiens lamin A/C protein. 58 2e-07
AL135927-2|CAI15520.1| 465|Homo sapiens lamin A/C protein. 58 2e-07
AL135927-1|CAI15521.1| 572|Homo sapiens lamin A/C protein. 58 2e-07
BX530088-4|CAI95787.1| 625|Homo sapiens GRIP1 associated protei... 58 3e-07
BC056146-1|AAH56146.1| 718|Homo sapiens hook homolog 3 (Drosoph... 58 3e-07
AY847595-1|AAW32538.1| 664|Homo sapiens lamin A/C transcript va... 58 3e-07
AF241830-1|AAK29204.1| 718|Homo sapiens golgi-associated microt... 58 3e-07
AF209746-1|AAF17621.1| 257|Homo sapiens beta tropomyosin protein. 58 3e-07
BC070281-1|AAH70281.1| 552|Homo sapiens HMMR protein protein. 58 4e-07
BC047324-1|AAH47324.1| 1217|Homo sapiens structural maintenance ... 58 4e-07
BC029425-1|AAH29425.1| 272|Homo sapiens Unknown (protein for IM... 58 4e-07
BC028366-1|AAH28366.1| 698|Homo sapiens testis specific, 10 pro... 58 4e-07
AL589649-3|CAH71820.1| 1213|Homo sapiens filamin A interacting p... 58 4e-07
AL589649-1|CAH71818.1| 1114|Homo sapiens filamin A interacting p... 58 4e-07
AL445465-2|CAH73615.1| 1213|Homo sapiens filamin A interacting p... 58 4e-07
AL445465-1|CAH73614.1| 1114|Homo sapiens filamin A interacting p... 58 4e-07
AL359260-2|CAI16576.1| 1217|Homo sapiens structural maintenance ... 58 4e-07
AL137068-7|CAD20123.1| 1007|Homo sapiens centrosomal protein 110... 58 4e-07
AK027705-1|BAB55310.1| 965|Homo sapiens protein ( Homo sapiens ... 58 4e-07
AF254756-1|AAK13079.1| 698|Homo sapiens predicted testis protei... 58 4e-07
AF223939-1|AAK00630.1| 2073|Homo sapiens ninein isotype 3 protein. 58 4e-07
AF223938-1|AAK00629.1| 2069|Homo sapiens ninein isotype 2 protein. 58 4e-07
AF223937-1|AAK00628.1| 2029|Homo sapiens ninein isotype 1 protein. 58 4e-07
AF212162-1|AAF23015.2| 2096|Homo sapiens ninein protein. 58 4e-07
AF020043-1|AAC14893.1| 1217|Homo sapiens chromosome-associated p... 58 4e-07
AC019097-1|AAY14820.1| 698|Homo sapiens unknown protein. 58 4e-07
AB086011-1|BAC77067.1| 1213|Homo sapiens L-FILIP protein. 58 4e-07
AB033101-1|BAA86589.1| 1140|Homo sapiens KIAA1275 protein protein. 58 4e-07
X06825-1|CAA29971.1| 284|Homo sapiens protein ( Human mRNA for ... 57 6e-07
D86958-1|BAA13194.2| 1593|Homo sapiens KIAA0203 protein. 57 6e-07
CR533556-1|CAG38587.1| 789|Homo sapiens TAX1BP1 protein. 57 6e-07
CR457056-1|CAG33337.1| 747|Homo sapiens TAX1BP1 protein. 57 6e-07
BC050358-1|AAH50358.1| 789|Homo sapiens Tax1 (human T-cell leuk... 57 6e-07
BC017556-1|AAH17556.1| 1594|Homo sapiens RB1-inducible coiled-co... 57 6e-07
AL133410-4|CAI10977.1| 284|Homo sapiens tropomyosin 2 (beta) pr... 57 6e-07
AL133410-3|CAI10976.1| 322|Homo sapiens tropomyosin 2 (beta) pr... 57 6e-07
AK023385-1|BAB14554.1| 284|Homo sapiens protein ( Homo sapiens ... 57 6e-07
AF268075-1|AAG03025.1| 747|Homo sapiens TRAF6-binding protein T... 57 6e-07
AF090891-1|AAF24016.1| 747|Homo sapiens PRO0105 protein. 57 6e-07
BC060037-1|AAH60037.1| 622|Homo sapiens KIAA1212 protein protein. 57 7e-07
BC025422-1|AAH25422.1| 676|Homo sapiens cut-like 1, CCAAT displ... 57 7e-07
AK024959-1|BAB15043.1| 696|Homo sapiens protein ( Homo sapiens ... 57 7e-07
AB059622-1|BAB69690.1| 1594|Homo sapiens Rb1-inducible coiled co... 57 7e-07
Y07759-2|CAA69036.1| 1828|Homo sapiens mysoin heavy chain 12 pro... 56 1e-06
BC033088-1|AAH33088.1| 465|Homo sapiens LMNA protein protein. 56 1e-06
AB252981-1|BAF48798.1| 506|Homo sapiens Nef-associated factor 1... 56 1e-06
AB209505-1|BAD92742.1| 1409|Homo sapiens Myosin Va variant protein. 56 1e-06
AB209487-1|BAD92724.1| 1409|Homo sapiens Myosin Va variant protein. 56 1e-06
S67238-1|AAB28950.1| 296|Homo sapiens smooth muscle myosin heav... 56 1e-06
M19267-1|AAA36771.1| 284|Homo sapiens protein ( Human tropomyos... 56 1e-06
BC007433-1|AAH07433.1| 284|Homo sapiens tropomyosin 1 (alpha) p... 56 1e-06
AK097021-1|BAC04928.1| 512|Homo sapiens protein ( Homo sapiens ... 56 1e-06
AB252979-1|BAF48796.1| 525|Homo sapiens Nef-associated factor 1... 56 1e-06
AB252976-1|BAF48793.1| 526|Homo sapiens Nef-associated factor 1... 56 1e-06
AB014555-1|BAA31630.1| 1083|Homo sapiens KIAA0655 protein protein. 56 1e-06
AB013384-1|BAA33713.1| 890|Homo sapiens HIP1R protein. 56 1e-06
Z22957-1|CAA80533.1| 812|Homo sapiens myosin I homologue protein. 56 2e-06
U39403-1|AAC99999.1| 500|Homo sapiens protein ( Human fetal cra... 56 2e-06
U33821-1|AAA75595.2| 747|Homo sapiens tax1-binding protein TXBP... 56 2e-06
D30755-1|BAA06416.2| 636|Homo sapiens KIAA0113 protein. 56 2e-06
BC014008-1|AAH14008.1| 636|Homo sapiens TNIP1 protein protein. 56 2e-06
BC012133-1|AAH12133.1| 636|Homo sapiens TNFAIP3 interacting pro... 56 2e-06
AL832009-1|CAD89912.1| 1177|Homo sapiens hypothetical protein pr... 56 2e-06
AJ011896-1|CAA09856.1| 635|Homo sapiens Naf1 beta protein protein. 56 2e-06
AJ011895-1|CAA09855.1| 636|Homo sapiens Naf1 alpha protein prot... 56 2e-06
AC002563-2|AAB71327.1| 1286|Homo sapiens WUGSC:H_127H14.1 protein. 56 2e-06
AB252982-1|BAF48799.1| 630|Homo sapiens Nef-associated factor 1... 56 2e-06
AB252980-1|BAF48797.1| 499|Homo sapiens Nef-associated factor 1... 56 2e-06
AB252978-1|BAF48795.1| 499|Homo sapiens Nef-associated factor 1... 56 2e-06
AB252977-1|BAF48794.1| 510|Homo sapiens Nef-associated factor 1... 56 2e-06
AB252973-1|BAF48790.1| 635|Homo sapiens Nef-associated factor 1... 56 2e-06
AB252972-1|BAF48789.1| 636|Homo sapiens Nef-associated factor 1... 56 2e-06
AB252971-1|BAF48788.1| 635|Homo sapiens Nef-associated factor 1... 56 2e-06
AB252970-1|BAF48787.1| 636|Homo sapiens Nef-associated factor 1... 56 2e-06
AB046821-1|BAB13427.1| 690|Homo sapiens KIAA1601 protein protein. 56 2e-06
BC103765-1|AAI03766.1| 691|Homo sapiens NUMA1 protein protein. 55 2e-06
BC103499-1|AAI03500.1| 898|Homo sapiens chromosome 10 open read... 55 2e-06
BC046212-1|AAH46212.1| 364|Homo sapiens Similar to cytomatrix p... 55 2e-06
BC027493-1|AAH27493.1| 691|Homo sapiens Unknown (protein for IM... 55 2e-06
AF273054-1|AAM44457.1| 613|Homo sapiens CTCL tumor antigen HD-C... 55 2e-06
BC068006-1|AAH68006.1| 627|Homo sapiens ERC1 protein protein. 55 3e-06
AY528715-1|AAT44400.1| 1016|Homo sapiens antigen MU-RMS-40.16A p... 55 3e-06
AF248540-1|AAF63600.1| 1681|Homo sapiens intersectin 2 protein. 55 3e-06
AC004549-1|AAC13359.2| 596|Homo sapiens unknown protein. 55 3e-06
AB033082-1|BAA86570.1| 1676|Homo sapiens KIAA1256 protein protein. 55 3e-06
DQ679757-1|ABG74698.1| 1215|Homo sapiens intersectin 1 short for... 54 4e-06
DQ679756-1|ABG74697.1| 1178|Homo sapiens intersectin 1 short for... 54 4e-06
DQ679755-1|ABG74696.1| 1149|Homo sapiens intersectin 1 short for... 54 4e-06
DQ679754-1|ABG74695.1| 1144|Homo sapiens intersectin 1 short for... 54 4e-06
DQ386455-1|ABD72328.1| 1020|Homo sapiens intersectin 1 short for... 54 4e-06
DQ340865-1|ABC69037.1| 1076|Homo sapiens intersectin 1 short for... 54 4e-06
BX538175-1|CAD98050.1| 627|Homo sapiens hypothetical protein pr... 54 4e-06
BC117560-1|AAI17561.1| 1144|Homo sapiens ITSN1 protein protein. 54 4e-06
BC116186-1|AAI16187.1| 1721|Homo sapiens intersectin 1 (SH3 doma... 54 4e-06
BC116185-1|AAI16186.1| 1716|Homo sapiens ITSN1 protein protein. 54 4e-06
BC051733-1|AAH51733.1| 1026|Homo sapiens LUZP1 protein protein. 54 4e-06
BC000099-1|AAH00099.4| 655|Homo sapiens RRBP1 protein protein. 54 4e-06
AY640414-1|AAT68294.1| 284|Homo sapiens sarcomeric tropomyosin ... 54 4e-06
AL031428-1|CAI19705.1| 1026|Homo sapiens leucine zipper protein ... 54 4e-06
AK131384-1|BAD18535.1| 326|Homo sapiens protein ( Homo sapiens ... 54 4e-06
AK129882-1|BAC85248.1| 217|Homo sapiens protein ( Homo sapiens ... 54 4e-06
AF114488-1|AAD29953.1| 1220|Homo sapiens intersectin short isofo... 54 4e-06
AF114487-1|AAD29952.1| 1721|Homo sapiens intersectin long isofor... 54 4e-06
AF064244-1|AAC78611.1| 1721|Homo sapiens intersectin long form p... 54 4e-06
AF064243-1|AAC78610.1| 1220|Homo sapiens intersectin short form ... 54 4e-06
AB033038-1|BAA86526.2| 802|Homo sapiens KIAA1212 protein protein. 54 4e-06
U83844-1|AAB41438.1| 319|Homo sapiens HIV-1 Nef interacting pro... 54 5e-06
BC115383-1|AAI15384.1| 684|Homo sapiens taxilin beta protein. 54 5e-06
AL831988-1|CAD91140.1| 718|Homo sapiens hypothetical protein pr... 54 5e-06
AK021545-1|BAB13841.1| 436|Homo sapiens protein ( Homo sapiens ... 54 5e-06
AF083811-1|AAD24498.1| 718|Homo sapiens mitotic checkpoint prot... 54 5e-06
AB177543-1|BAF34946.1| 572|Homo sapiens NEF-associated factor 1... 54 5e-06
Z97832-4|CAI20190.1| 631|Homo sapiens differentially expressed ... 54 7e-06
BX537964-1|CAD97928.1| 898|Homo sapiens hypothetical protein pr... 54 7e-06
BX530088-1|CAI95784.1| 810|Homo sapiens GRIP1 associated protei... 54 7e-06
BC105632-1|AAI05633.1| 898|Homo sapiens chromosome 10 open read... 54 7e-06
BC100670-1|AAI00671.1| 1004|Homo sapiens C10orf118 protein protein. 54 7e-06
BC028423-1|AAH28423.1| 1022|Homo sapiens PMFBP1 protein protein. 54 7e-06
AY241694-1|AAO91767.1| 631|Homo sapiens IRF4-binding protein pr... 54 7e-06
AY012155-1|AAG42154.1| 636|Homo sapiens virion-associated nucle... 54 7e-06
AJ276095-1|CAC08450.1| 631|Homo sapiens Def-6 protein protein. 54 7e-06
AF527734-1|AAP85633.1| 439|Homo sapiens medulloblastoma antigen... 54 7e-06
AF034799-1|AAC26100.1| 1257|Homo sapiens liprin-alpha2 protein. 54 7e-06
AB177544-1|BAF34947.1| 556|Homo sapiens NEF-associated factor 1... 54 7e-06
X98801-1|CAA67333.1| 1263|Homo sapiens dynactin protein. 53 9e-06
BC071583-1|AAH71583.1| 1139|Homo sapiens DCTN1 protein protein. 53 9e-06
AF317887-1|AAK01919.1| 589|Homo sapiens monoclonal antibody 3H1... 53 9e-06
AF086947-1|AAD03694.1| 1261|Homo sapiens dynactin 1 protein. 53 9e-06
AF064205-2|AAD55812.1| 1144|Homo sapiens dynactin 1 p135 isoform... 53 9e-06
AF064205-1|AAD55811.1| 1278|Homo sapiens dynactin 1 p150 isoform... 53 9e-06
AB209625-1|BAD92862.1| 459|Homo sapiens dynactin 1 isoform 1 va... 53 9e-06
BC067085-1|AAH67085.1| 615|Homo sapiens HIP1R protein protein. 53 1e-05
BC033545-1|AAH33545.1| 700|Homo sapiens cancer antigen 1 protein. 53 1e-05
BC026194-1|AAH26194.1| 700|Homo sapiens cancer antigen 1 protein. 53 1e-05
AY651261-1|AAX35689.1| 1244|Homo sapiens centrosomal protein 1 p... 53 1e-05
AL139095-7|CAI16451.1| 847|Homo sapiens cancer antigen 1 protein. 53 1e-05
AL139095-5|CAI16449.1| 545|Homo sapiens cancer antigen 1 protein. 53 1e-05
AL137068-6|CAI12359.1| 346|Homo sapiens centrosomal protein 110... 53 1e-05
AK097760-1|BAC05162.1| 824|Homo sapiens protein ( Homo sapiens ... 53 1e-05
AF414185-1|AAO47239.1| 641|Homo sapiens CAGE-1 protein. 53 1e-05
X04201-1|CAA27798.1| 285|Homo sapiens protein ( Human skeletal ... 52 2e-05
BC115701-1|AAI15702.1| 828|Homo sapiens SLMAP protein protein. 52 2e-05
BC009964-1|AAH09964.1| 718|Homo sapiens MAD1 mitotic arrest def... 52 2e-05
BC008425-1|AAH08425.1| 285|Homo sapiens tropomyosin 3 protein. 52 2e-05
BC008407-1|AAH08407.1| 285|Homo sapiens tropomyosin 3 protein. 52 2e-05
AY237538-1|AAP04415.1| 1304|Homo sapiens KIF27C protein. 52 2e-05
AL590431-11|CAH71269.1| 284|Homo sapiens tropomyosin 3 protein. 52 2e-05
AF123318-1|AAD20359.1| 718|Homo sapiens mitotic checkpoint prot... 52 2e-05
BX640704-1|CAE45824.1| 594|Homo sapiens hypothetical protein pr... 52 2e-05
BX530088-3|CAI95786.1| 841|Homo sapiens GRIP1 associated protei... 52 2e-05
BX530088-2|CAI95785.1| 796|Homo sapiens GRIP1 associated protei... 52 2e-05
BC101546-1|AAI01547.1| 841|Homo sapiens GRIP1 associated protei... 52 2e-05
BC101544-1|AAI01545.1| 841|Homo sapiens GRIP1 associated protei... 52 2e-05
AL590431-9|CAH71267.1| 248|Homo sapiens tropomyosin 3 protein. 52 2e-05
AB032993-1|BAA86481.1| 834|Homo sapiens KIAA1167 protein protein. 52 2e-05
BC130564-1|AAI30565.1| 905|Homo sapiens KIAA1524 protein. 52 3e-05
BC017659-1|AAH17659.1| 285|Homo sapiens KIAA1524 protein protein. 52 3e-05
AY166586-1|AAN86031.1| 1638|Homo sapiens CDC42-binding protein k... 52 3e-05
AM177180-1|CAJ45484.1| 1670|Homo sapiens kinesin-like protein KI... 52 3e-05
AL590431-10|CAH71268.1| 247|Homo sapiens tropomyosin 3 protein. 52 3e-05
AK074153-1|BAB84979.1| 1046|Homo sapiens FLJ00226 protein protein. 52 3e-05
AK022912-1|BAB14305.1| 472|Homo sapiens protein ( Homo sapiens ... 52 3e-05
AK002071-1|BAA92068.1| 528|Homo sapiens protein ( Homo sapiens ... 52 3e-05
AF334474-1|AAL11632.1| 905|Homo sapiens p90 autoantigen protein. 52 3e-05
AB040957-1|BAA96048.1| 884|Homo sapiens KIAA1524 protein protein. 52 3e-05
AB007918-1|BAA32294.2| 1628|Homo sapiens KIAA0449 protein protein. 52 3e-05
BX004861-1|CAI41713.1| 528|Homo sapiens chromosome X open readi... 51 4e-05
BC112273-1|AAI12274.1| 830|Homo sapiens kinesin family member 7... 51 4e-05
BC112271-1|AAI12272.1| 830|Homo sapiens kinesin family member 7... 51 4e-05
BC104044-1|AAI04045.1| 830|Homo sapiens kinesin family member 7... 51 4e-05
BC101576-1|AAI01577.1| 528|Homo sapiens chromosome X open readi... 51 4e-05
BC101572-1|AAI01573.1| 528|Homo sapiens gamma-taxilin protein. 51 4e-05
>U31906-1|AAC51791.1| 2083|Homo sapiens golgin-245 protein.
Length = 2083
Score = 126 bits (304), Expect = 8e-28
Identities = 281/1457 (19%), Positives = 599/1457 (41%), Gaps = 130/1457 (8%)
Query: 163 DSLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFL 222
+ L ER+++++ +K + EK I + R+ ++L + E +K + + + + +
Sbjct: 176 EQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLE-M 234
Query: 223 MQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDI 282
+ + ++ + +K G S ++ ++ LK E+D
Sbjct: 235 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 294
Query: 283 LRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSE--VLKLQQKVNELTTHNEDLRDEK 340
K E+ +E+ L + L+ + +SSE + KLQ+ H ++L ++
Sbjct: 295 QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK------LHEKELARKE 348
Query: 341 KHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL-MDENEDMKKELRDLX 399
+ LT+K++ E E + + + Q E L K+ + E L ++E E KK + L
Sbjct: 349 QELTKKLQTREREFQEQMKVALEKSQSEYL--KISQEKEQQESLALEELELQKKAI--LT 404
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKL 459
++D + +A+ Y + ELE +++ + L +++ A LE EK +H K++
Sbjct: 405 ESENKLRD--LQQEAETYRTRILELESSLE--KSLQENENQSKDLAVHLEAEKNKHNKEI 460
Query: 460 LEIVGGPDGMQRENRIKELEQEVARSTEVAL---RLQRELAEANSKFTGSNPSLMK---- 512
+V + + E + +Q+ + E+ + + Q E+ + K +L+K
Sbjct: 461 TVMV---EKHKTELESLKHQQDALWAEELQVLKQQYQTEMEKLREKCEQEKETLLKDKEI 517
Query: 513 VPQPETVKVSRSSLTR-GGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNP 571
+ Q +++ +L + +Q + L +L + L+ L E+L +++T KQ
Sbjct: 518 IFQAHIEEMNEKTLEKLDVNQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ-EL 576
Query: 572 PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS-KEKSDSPPLSI---DKTT 627
+D+Q H + V + I+ + T + K++ + L + DK
Sbjct: 577 EAKMDEQKN---------HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHL 627
Query: 628 EETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN 687
+E Q H + I + L++ +A++ D TKA +L+
Sbjct: 628 KEHQAHVENLEADI--KRSEGELQQASAKL--DVFQSYQSATHEQTKAYEEQLAQLQQ-K 682
Query: 688 KLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTS 747
L +ET K+ E + + + EL+ + V + +++LE+ ++++VK LT
Sbjct: 683 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV-QDLMQQLEKQNSEMEQKVKSLTQ 741
Query: 748 KISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
S + ++ L N + + R + + EI+ + +KL KE L+ E
Sbjct: 742 VYESKLEDGNKEQEQTKQILVEKENMILQMR-EGQKKEIEILTQKLSAKEDSIHILNEEY 800
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA-KTQSLEADNEKLQTENK 866
K + ++ A + Q LK++L ++QEA + + + +LE ++ Q K
Sbjct: 801 ETKFKNQEKKMEKVKQKAKEMQET-LKKKL--LDQEAKLKKELENTALELSQKEKQFNAK 857
Query: 867 KLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEK-----KVR 921
L++ + + SD L T + Q+E+ + ++ ++ I + + +++ ++
Sbjct: 858 MLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIH 917
Query: 922 FTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK--SLKDDAQKSFKPRIPKK 979
+ +KE + + KQ + +K + ++ Q+ K +
Sbjct: 918 EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHV 977
Query: 980 PTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE---IDEIRSKLSK 1036
+ + +LK +E LE ++ + + +N L + + K E++ + E+ SKL
Sbjct: 978 NSLAQDETKLKAHLEKLEVDLNKS--LKENTFLQEQLVELKMLAEEDKRKVSELTSKLKT 1035
Query: 1037 NDSEF-----TNEKNR--LQTEIAKLKDVNAKLEGDKDVFANKYKAL-ENENSNLSNQCK 1088
D EF ++EK+ L+ + + K ++ +L D+ K +AL E + + L N
Sbjct: 1036 TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISS 1095
Query: 1089 TLTEEMKNREAQINKLSADLKNATSLQT-TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
+ T + +R + + +K A ++T T+S+ Q++
Sbjct: 1096 SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE 1155
Query: 1148 ---NYTK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXX 1203
N K + D L+ E K+ G+ +++K+LS + VT
Sbjct: 1156 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1215
Query: 1204 XXXXXXXQAVVLANTHRRLSIELTSE--KDELQARFIKTESKFITLEAEMRDLKADYENK 1261
+ L+ L+++L + E +A ++ + E+ D D K
Sbjct: 1216 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1275
Query: 1262 ITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDEL 1321
+ +L K ++Q++D ++K+ E + Q+ +
Sbjct: 1276 VDTLSKE---KISALEQVDD-----WSNKFSEWKKKAQ------------SRFTQHQNTV 1315
Query: 1322 NNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELD 1381
+I+LE E+ ++ LK +L + S E K L+
Sbjct: 1316 KELQIQLELKSKEAYEKDEQINLLKEEL---DQQNKRFDCLKGEMEDDKSKMEKKESNLE 1372
Query: 1382 TDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
T+L+S+ ++ + + + K E+ +L LK Q K + + Q ++E
Sbjct: 1373 TELKSQTARIMEL----EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELG 1428
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEI 1501
++ ++ + ++AE + LT LE + KA L +K+ EL HV + + E+
Sbjct: 1429 EEKDNRV--KEAEEKILT-----LENQVYSMKAELETKKK----ELEHVNLSVKSKEEEL 1477
Query: 1502 KTLQEKLGTESAAWNTE-KTEMQNSIASLQERLCGG----------GWEVERARLNARLD 1550
K L+++L +ESAA E K + + IA+++++L G E + LN +L
Sbjct: 1478 KALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQ 1537
Query: 1551 QRERELRAANDRRDVLE 1567
+RERE+ ++ +E
Sbjct: 1538 EREREVHILEEKLKSVE 1554
Score = 93.1 bits (221), Expect = 9e-18
Identities = 276/1489 (18%), Positives = 575/1489 (38%), Gaps = 113/1489 (7%)
Query: 154 QTQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEK-ERERRSLSKSKEDEKTARYKD-- 210
+T+L K+ A ++Q+LK Q E E EK E+E+ +L K KE A ++
Sbjct: 468 KTELESLKHQQDALWAEELQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 527
Query: 211 ERSSTKDDVNF---------LMQVKNSRNSTNLKPPV---RGGPXXXXXXXXXXXXXXXX 258
E++ K DVN L +V +R+ + V +
Sbjct: 528 EKTLEKLDVNQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 587
Query: 259 XXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSE 318
VDS +KE++ I+ ++ + + E + KE+ L A+++ E
Sbjct: 588 QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 647
Query: 319 VLKLQQKVN-----ELTTHNEDLRDEKK--HLTQKIREIESE--LETR--PSTEAQTRQI 367
+ + K++ + TH + E++ L QK+ ++E+E L T+ EAQ + +
Sbjct: 648 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 707
Query: 368 -EQLRAKLLAAETLCEELMDENEDMKKELRDLX-XXXXXMQDNFREDQADEYSSLRRE-- 423
+L A + + L ++L +N +M+++++ L ++D +E + + + +E
Sbjct: 708 CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM 767
Query: 424 ----LEQTIKNCRVLSFKLKKTERKA----DQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
E K +L+ KL E ++ E + EKK+ ++ MQ +
Sbjct: 768 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 827
Query: 476 KELEQEVARSTEV---ALRLQR----------ELAEANSKFTGSNPSLMKVPQPETVKVS 522
K L+QE E+ AL L + E+A+ANS S ++ Q E ++ S
Sbjct: 828 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE-S 886
Query: 523 RSSLTRGGSQEDPAQLLRDLQDSLEREADLRE-QLRNAEEETANCKQVNPPTFLDKQVMT 581
+ + R + + + L E ++ E QL+ E+E A KQ +K+ M
Sbjct: 887 LTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMN 946
Query: 582 DNIVTCDIH--ESETVTNSIQNKM------IHAASTPSSKEKSDSPPLSID--KTTEETQ 631
I + +T N +Q ++ +++ + +K K+ L +D K+ +E
Sbjct: 947 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1006
Query: 632 F----HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN 687
F +L L+ + + L +E+ +SL +K + L +
Sbjct: 1007 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1066
Query: 688 KLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTS 747
+L+I+ D K+T+ A+ L+ ++ + + ++ + +K + L
Sbjct: 1067 ELAIQL--DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVK---EALLI 1121
Query: 748 KISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
K +V++ A R LT N L + +++E ++ + D E L E
Sbjct: 1122 KTCTVSELEA-----QLRQLTEEQNTL-NISFQQATHQLEEKENQIKSMKADIESLVTEK 1175
Query: 808 SLAQKKPKTLIKSRSLDAS--DQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
QK+ ++ S S Q +L + + L+ K + + +++L N
Sbjct: 1176 EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN 1235
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEA 925
+LQ N+ SL +A + +K Q + E E L ++++L D S++K+ E
Sbjct: 1236 VQLQ---NSISLSEKEAAISSLRK--QYDEEKCELLDQVQDLSFKV-DTLSKEKISALEQ 1289
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT 985
++ S+ Q LKS K+ +K + + K+ D
Sbjct: 1290 VDDWSNKF-SEWKKKAQSRFTQHQNTVKELQIQLELKS-KEAYEKDEQINLLKEELDQQN 1347
Query: 986 KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK 1045
K + + ++E + +M N K TA+ +E E D I K + +S K
Sbjct: 1348 K-RFDCLKGEMEDDKSKMEKKESNLETELKSQTARI-MELE-DHITQKTIEIESLNEVLK 1404
Query: 1046 NRLQTEIAKLKDVNAKLEGDKDVFA---NKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
N Q + + K++ KL+ +++ N+ K E + L NQ ++ E++ ++ ++
Sbjct: 1405 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE 1464
Query: 1103 KLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLK- 1161
++ +K+ + D + + +++++ + + K
Sbjct: 1465 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1524
Query: 1162 ---EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLS-----TRKDRVTXXXXXXXXXXXQAV 1213
+ + K+ + K +E S R + Q
Sbjct: 1525 TESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGC 1584
Query: 1214 VLANTHRRLSI--ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAA 1271
V ++S+ +EK++L R + + + ++ EMR Y+ ++ LE A
Sbjct: 1585 VQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR---CQYQERLIKLEHA-EA 1640
Query: 1272 KDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT 1331
K + + L++ +K + + V + ++ ++ + L++
Sbjct: 1641 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1700
Query: 1332 EAESSAAKLEMAQLKSDLAK-LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER-K 1389
E + ++ +L S L + E + + + T+L E +
Sbjct: 1701 ELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTE 1760
Query: 1390 KLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLA 1449
+ + + K + N +A+ L+ KL E+ K I L+++ K+ + L
Sbjct: 1761 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELE 1820
Query: 1450 LEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLG 1509
+ K EY++ + E+E + K T+++ + QKE + +T+ +
Sbjct: 1821 ILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQE 1880
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
E+ + + E + + E+ + R LD RE E+ A
Sbjct: 1881 VEAELLESHQEETNQLLKKIAEK--DDDLKRTAKRYEEILDAREEEMTA 1927
Score = 87.0 bits (206), Expect = 6e-16
Identities = 263/1551 (16%), Positives = 589/1551 (37%), Gaps = 112/1551 (7%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCER----VEKEKSDILLRRLANIDTANKYTTGRSSE 318
D++++E I L+ +V +L++R V+ K L A + T +
Sbjct: 66 DASLEEKDQHISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEP 125
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE--TRPSTEAQTRQIEQLRAKLLA 376
V++ V L T + ++ ++ L + I+S E T ++E + Q EQL +L
Sbjct: 126 VVEDGASVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQ-EQLDERLQE 184
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
E + + M E + +LRD ++ + A+ + LE + L
Sbjct: 185 LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 244
Query: 437 KLKKTERKADQLEQEKAEHEKKLLE-----IVGGPDGMQRENRIK-ELEQEV----ARST 486
++K+ + ++L ++K + E+ E + + ++K E+++++ S
Sbjct: 245 RIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE 304
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL---RDLQ 543
E + LQ+EL+ + + + K+ L R QE +L R+ Q
Sbjct: 305 EERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELAR-KEQELTKKLQTREREFQ 363
Query: 544 DSLE--READLREQLR-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ 600
+ ++ E E L+ + E+E + K ++T++ + E T +
Sbjct: 364 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 423
Query: 601 NKMIHAASTPSSKE-KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKT-----A 654
+ ++ S +E ++ S L++ E+ + + ++ + + +L+ A
Sbjct: 424 ILELESSLEKSLQENENQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWA 483
Query: 655 ARVEEDNESLLLQLKKMATKARSRK---LSPTPPANKLSIETANDN-----DEKETD-EA 705
++ + +++K+ K K L + IE N+ D +T+ E+
Sbjct: 484 EELQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVNQTELES 543
Query: 706 DPAEMKLLLELN---EQEATVLRRKVEELEQDKEA-LKKQVKELTSKISSVTKTSAGSNT 761
+E+ +L+ E+E +VL+ + ++++Q+ EA + +Q ++ S+ K S
Sbjct: 544 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ 603
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
++L N+L E +K + + E + + E D +R EL A K +
Sbjct: 604 RTEKALKDQINQL-ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ 662
Query: 822 S-----LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKNA 874
S A ++Q L+++L +E E +L + +EA + + TE K+Q+
Sbjct: 663 SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 722
Query: 875 KSL-RSDKALDLNTKKTTQL-ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+ L + + ++ K TQ+ E++L++ + ++ + I EK ++ E KKE +
Sbjct: 723 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV-EKENMILQMREGQKKEIEI 781
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
L K Q K + + KK D K LKK
Sbjct: 782 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK--LKKE 839
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI 1052
+E+ E+ + NA + + + + + + T R ++
Sbjct: 840 LENTALELSQKEKQF-NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV 898
Query: 1053 AKL--KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
+ K +N + E +++ + + E E + L + E + +I L +
Sbjct: 899 ISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK---EE 955
Query: 1111 ATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
TT+++ ++ K++ D NK LKE +++
Sbjct: 956 GVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE---KLEVDLNKSLKENTFLQEQL 1012
Query: 1171 GDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK 1230
+ + +L T + + ++LS EL +
Sbjct: 1013 VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQL 1072
Query: 1231 D----ELQARFIKTESKFITLEAEMRDL----KADYENKITSLESTIAAKDVHIKQLEDA 1282
D + +A ++ I + + + + +++ T ++ + K + +LE
Sbjct: 1073 DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ 1132
Query: 1283 LRQ------TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
LRQ T N + +AT +E E + + E ++ E + +
Sbjct: 1133 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE----ALQKEGGNQQQA 1188
Query: 1337 AAKLE--MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQ-----SERK 1389
A++ E + QLK +L++ N S + +L+ LQ SE++
Sbjct: 1189 ASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKE 1248
Query: 1390 -KLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
+ +R +D++ ++ L K+ L + + +++ + ++ E KK +
Sbjct: 1249 AAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRF 1308
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ +EL + EL +E ++ + KE EL K GE++ + K+
Sbjct: 1309 TQHQNTVKELQIQLELKSKEAYEKDEQINLLKE----ELDQQNKRFDCLKGEMEDDKSKM 1364
Query: 1509 GTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEH 1568
+ + TE I L++ + E+E + +++++ + +++++
Sbjct: 1365 EKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDI----EHKELVQK 1420
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITD 1628
E++ ++ + S K+++ E+
Sbjct: 1421 LQHFQELGEEKDNRVKEAEEKILTLEN-QVYSMKAELETKKKELEHVNLSVKSKEEELKA 1479
Query: 1629 TKTRYEGQMNTMRDELK-SLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRN 1687
+ R E + ELK +++ + KQ+L ++ + K G +S H +
Sbjct: 1480 LEDRLESESAAKLAELKRKAEQKIAAIK------KQLLSQMEEKEEQYKKGTES---HLS 1530
Query: 1688 SISSTDEEEYRNKVALLEQQVACLEDELCESRLL-ASKLNTELVSEKSSAE 1737
+ +T +E +V +LE+++ +E E+ ++ S N +E+ A+
Sbjct: 1531 EL-NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD 1580
Score = 72.1 bits (169), Expect = 2e-11
Identities = 260/1444 (18%), Positives = 540/1444 (37%), Gaps = 100/1444 (6%)
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
K +EL T + L+ EKK L Q I + R E + E+L+ A + L EE
Sbjct: 11 KYSELVTAYQMLQREKKKL-QGILSQSQDKSLRKIAELR----EELQMDQQAKKHLQEEF 65
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
E+ + + L ++ R + + + L Q V + K + E
Sbjct: 66 DASLEEKDQHISVLQTQVSLLKQRLRNGPMNV--DVLKPLPQLEPQAEVFT-KEENPESD 122
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
+ + ++ A K LE + Q EN +K ++ + E L E +
Sbjct: 123 GEPVVEDGAS--VKTLETLQQRVKRQ-ENLLKRCKETIQSHKEQCTLLTSEKEALQEQLD 179
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL-EREADLREQLRNAEEET 563
L K+ + ++ ++ QL +D + E + + E L EEE
Sbjct: 180 ERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEI 239
Query: 564 ANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
A + + + + + E + ++ + K + D +I
Sbjct: 240 AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTI 299
Query: 624 DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPT 683
+KT+EE + LS + ++K++ E + +L+K+ K +RK
Sbjct: 300 EKTSEEERISLQQE-LSRVKQEVVDVMKKSS-------EEQIAKLQKLHEKELARKEQEL 351
Query: 684 PPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVK 743
+ + + +++ +K+ E +QE+ L EELE K+A+
Sbjct: 352 TKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL----EELELQKKAI----- 402
Query: 744 ELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERL 803
LT + + + T R L +L K L++ ++ + + E + +
Sbjct: 403 -LTESENKLRDLQQEAETYRTRIL-----ELESSLEKSLQENENQSKDLAVHLEAEKNKH 456
Query: 804 HAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQT 863
+ E+++ +K KT ++S QQ+ +LQV++Q+ K + ++
Sbjct: 457 NKEITVMVEKHKTELES----LKHQQDALWAEELQVLKQQYQTEMEKLREKCEQEKETLL 512
Query: 864 ENKKLQLLKNAKSLRSD--KALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVR 921
++K++ + + + + LD+N + L +EL E L +LE +E S K +
Sbjct: 513 KDKEIIFQAHIEEMNEKTLEKLDVNQTELESLSSELSEVLKARHKLE----EELSVLKDQ 568
Query: 922 FTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPT 981
T+ K+E + K + Q T K+LKD + + K
Sbjct: 569 -TDKMKQELEA-KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL---ELLLKER 623
Query: 982 DLTTKLQLKKMVEDLECEI----GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKN 1037
D K + + VE+LE +I GE+ + +A + K +E ++L +
Sbjct: 624 DKHLK-EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 682
Query: 1038 DSEFTNEKNRLQTEIAKL----KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEE 1093
+ E+ L ++A++ KDV +L+ K + + LE +NS + + K+LT+
Sbjct: 683 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 742
Query: 1094 MKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN--YTK 1151
+++ NK K + M M + N Y
Sbjct: 743 YESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 802
Query: 1152 IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQ 1211
+++ K +++V K K++ + +++K+L ++ +
Sbjct: 803 KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEA--KLKKEL---ENTALELSQKEKQFNAK 857
Query: 1212 AVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAA 1271
+ +A + + S + Q I ES E+ D+ + +E K+ +
Sbjct: 858 MLEMAQANSAGISDAVSRLETNQKEQI--ESLTEVHRRELNDVISIWEKKLNQQAEEL-- 913
Query: 1272 KDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT 1331
+++H QL++ ++ K E EM LN + +L++
Sbjct: 914 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 973
Query: 1332 EAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL 1391
A ++ + +LK+ L KLE +++ + + EL + +++K+
Sbjct: 974 SAHVNSLAQDETKLKAHLEKLE-------VDLNKSLKENTFLQEQLVELKMLAEEDKRKV 1026
Query: 1392 DRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALE 1451
+ +K D E +LK + + N K + E K+ EE +L+
Sbjct: 1027 SELT----SKLKTTDEEFQSLKSSHE--KSNKSLEDKSL-EFKKLSEELAIQLDICCKKT 1079
Query: 1452 KAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
+A E T EL+ T A L+ Q V++ L + L+ +L
Sbjct: 1080 EALLEAKTN--ELINISSSKTNAILS-RISHCQHRTTKVKEALLIKTCTVSELEAQLRQL 1136
Query: 1512 SAAWNTEKTEMQNSIASLQER---LCGGGWEVERARLNARLDQRE--RELRAANDRRDVL 1566
+ NT Q + L+E+ + ++E Q+E + +AA+++ +
Sbjct: 1137 TEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI 1196
Query: 1567 EHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEI 1626
+ + K++ I SEK +A I
Sbjct: 1197 TQLKKELSENINAVTLMKEELKE-KKVE--ISSLSKQLTDLNVQLQNSISLSEK--EAAI 1251
Query: 1627 TDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARI-H 1685
+ + +Y+ + + D+++ L +V +E+ + + ++ +E K +S H
Sbjct: 1252 SSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQH 1311
Query: 1686 RNSISSTDEE-EYRNKVAL-LEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEM 1743
+N++ + E ++K A ++Q+ L++EL + L E+ +KS E + + +
Sbjct: 1312 QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1371
Query: 1744 QSRL 1747
++ L
Sbjct: 1372 ETEL 1375
Score = 51.6 bits (118), Expect = 3e-05
Identities = 123/618 (19%), Positives = 241/618 (38%), Gaps = 61/618 (9%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D+ VKE +++I L+ +V ++ E +KE + L + + SE
Sbjct: 1432 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAA- 1490
Query: 323 QQKVNELTTHNED-LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET-- 379
K+ EL E + KK L ++ E E + + TE+ + +L KL E
Sbjct: 1491 --KLAELKRKAEQKIAAIKKQLLSQMEEKEEQY--KKGTESH---LSELNTKLQEREREV 1543
Query: 380 -LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ EE + E + E + + +++AD +++ E+ I VL L
Sbjct: 1544 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS---VLQRNL 1600
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTE---VALRLQRE 495
+ E+ ++ QEK E E+ Q + R+ +LE A+ E + LQ E
Sbjct: 1601 TEKEKLLQRVGQEKEETVSSHFEM-----RCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1655
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
L E N K++ + V Q + ++++ ++++ + D+Q +L+ + +
Sbjct: 1656 LEEKNKKYS------LIVAQHVEKEGGKNNIQ---AKQNLENVFDDVQKTLQEKELTCQI 1706
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
L +E +C L +Q + E E +T+ + + A + K
Sbjct: 1707 LEQKIKELDSC--------LVRQKEVHRV------EMEELTSKYEK--LQALQQMDGRNK 1750
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
L + T E+++ H P L N+L A E + + L ++ ++
Sbjct: 1751 PTE--LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL 1808
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK---LLLELNEQEATVLRRKVEELE 732
R + L E + +EK E + E+K L +L + T L +K +ELE
Sbjct: 1809 RMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELE 1868
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
+K+ + + + + ++ + + + L + K E+ +D ++
Sbjct: 1869 M---TIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDL-KRTAKRYEEILDAREEE 1924
Query: 793 LIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-DLKRQLQVIEQEASVLRAKT 851
+ K RD L +L QKK + ++ +D + +L+ QL S + K
Sbjct: 1925 MTAKVRD---LQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE 1981
Query: 852 QSLEADNEKLQTENKKLQ 869
Q L+ KK +
Sbjct: 1982 QEFREQIHNLEDRLKKYE 1999
Score = 48.4 bits (110), Expect = 3e-04
Identities = 62/369 (16%), Positives = 154/369 (41%), Gaps = 16/369 (4%)
Query: 1444 LEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKT 1503
+E SL+ + +Y EL Y++L+ E + L+ ++++ ++ +++EL K
Sbjct: 1 MERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRKIAELREELQMDQQAKKH 60
Query: 1504 LQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD-QRE---RELRAA 1559
LQE+ + + +Q ++ L++RL G V+ + +L+ Q E +E
Sbjct: 61 LQEEFDASLEEKDQHISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPE 120
Query: 1560 NDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE 1619
+D V+E E + K + +++
Sbjct: 121 SDGEPVVE--DGASVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQL 178
Query: 1620 KARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRER-----DNYKQM---LEAAQKS 1671
R E+ K + + + +L+ N + + +++ + +QM LE ++
Sbjct: 179 DERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEE 238
Query: 1672 MAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVS 1731
+A++++ K + E+ R LE+ ++ + R L ++++ ++ +
Sbjct: 239 IAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKT 298
Query: 1732 -EKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETST 1790
EK+S E R++ +Q L+ ++E + ++ +A +L + ++Q L ++ T
Sbjct: 299 IEKTSEEERIS-LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT 357
Query: 1791 LARDLRQTL 1799
R+ ++ +
Sbjct: 358 REREFQEQM 366
Score = 45.6 bits (103), Expect = 0.002
Identities = 96/581 (16%), Positives = 232/581 (39%), Gaps = 46/581 (7%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRD-LKADYENKI---TSLESTIAAKDVHIKQLED 1281
L EK +LQ +++ K + AE+R+ L+ D + K ++++ KD HI L+
Sbjct: 22 LQREKKKLQGILSQSQDKSLRKIAELREELQMDQQAKKHLQEEFDASLEEKDQHISVLQT 81
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
Q + K P+ + ++ ++E N + E + ++ K
Sbjct: 82 ---QVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEE--NPESDGEPVVEDGASVKT- 135
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+ L+ + + EN + ++ + L L ++L++++ H +
Sbjct: 136 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 195
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+L K ++ LEQ+ G I E K++ ET++ E +A ++ +++T +
Sbjct: 196 KTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQMHETLEMKEEEIAQLRSRIKQMTTQ 252
Query: 1462 YELLEEEHVVTKARLTVEKEQAQG---ELLHVQKELSTALGE-IKTLQEKLGTESAAWNT 1517
E L E+ ++ E E+A + +++L + E IKT+++ E +
Sbjct: 253 GEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQ 312
Query: 1518 EKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXX 1577
E + ++ + + ++ E + A+L +L ++E + + + +
Sbjct: 313 ELSRVKQEVVDVMKK----SSEEQIAKLQ-KLHEKELARKEQELTKKLQTREREFQEQMK 367
Query: 1578 XXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTR---YE 1634
+Y ++S+ + +E+ E +KA +T+++ + +
Sbjct: 368 VALEKSQSEYLKISQEKE-------------QQESLALEELELQKKAILTESENKLRDLQ 414
Query: 1635 GQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARI--HRNSISST 1692
+ T R + L + + + +E +N + L ++ N + + + H+ + S
Sbjct: 415 QEAETYRTRILELESSLEKSLQENENQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESL 474
Query: 1693 DEEE---YRNKVALLEQQVACLEDEL---CESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
++ + ++ +L+QQ ++L CE + E++ + E+ ++
Sbjct: 475 KHQQDALWAEELQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 534
Query: 1747 LNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQE 1787
E LSS + V ++E +D+ ++ QE
Sbjct: 535 DVNQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE 575
Score = 44.8 bits (101), Expect = 0.003
Identities = 116/603 (19%), Positives = 254/603 (42%), Gaps = 62/603 (10%)
Query: 1211 QAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA 1270
+ +V+A T R++ L +++E+ +++ K +T + E +L+ E +S A
Sbjct: 217 KGMVIAETKRQMHETLEMKEEEIAQ--LRSRIKQMTTQGE--ELREQKE------KSERA 266
Query: 1271 AKDVHIKQLEDALRQTTNDKYDEATSPV--EMVE-MRXXXXXXXXXXXXXQDELNNAK-- 1325
A ++LE AL +T K +EA + EM E ++ Q EL+ K
Sbjct: 267 A----FEELEKAL--STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE 320
Query: 1326 -IKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL 1384
+ + K +E AKL+ K +LA+ E + + + L
Sbjct: 321 VVDVMKKSSEEQIAKLQKLHEK-ELARKEQELTKKLQTREREFQEQMKVALEKSQSEY-L 378
Query: 1385 QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKL 1444
+ ++K + +A ++ K A L + KL+ L+Q + RI EL+ E+++++
Sbjct: 379 KISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN 438
Query: 1445 EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTL 1504
E+ + ++L E + +H + + VEK + + E L Q++ A E++ L
Sbjct: 439 EN-------QSKDLAVHLEAEKNKH-NKEITVMVEKHKTELESLKHQQDALWA-EELQVL 489
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA-ANDRR 1563
+++ TE + + + ++ +E + E + +LD + EL + +++
Sbjct: 490 KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVNQTELESLSSELS 549
Query: 1564 DVLEHHHD-XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
+VL+ H E +K+ I+++EKA
Sbjct: 550 EVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL 609
Query: 1623 KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEA-AQKSMAEIKNGDKS 1681
K +I ++L+ L + + +E + + LEA ++S E++
Sbjct: 610 KDQI---------------NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 654
Query: 1682 ARIHRNSISSTDEE--EYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEK----SS 1735
+ ++ S+T E+ Y ++A L+Q++ LE E R+L +K E+ ++K +
Sbjct: 655 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE----RILLTKQVAEVEAQKKDVCTE 710
Query: 1736 AEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA-WHKERDEQQRLLQETSTLARD 1794
+ ++Q + + E++ + + +L +KE+++ +++L E +
Sbjct: 711 LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 770
Query: 1795 LRQ 1797
+R+
Sbjct: 771 MRE 773
>D10667-1|BAA36971.1| 1052|Homo sapiens smooth muscle myosin heavy
chain protein.
Length = 1052
Score = 113 bits (273), Expect = 5e-24
Identities = 210/1055 (19%), Positives = 422/1055 (40%), Gaps = 92/1055 (8%)
Query: 318 EVL-KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQL--RAKL 374
E+L +++ ++ E + L+ E+K + Q++ ++E +LE + Q Q+E++ AK+
Sbjct: 36 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQLEKVTAEAKI 94
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNF--REDQADEYSSLRRELEQTIKNCR 432
E + D+N + KE + L + N E++A + L+ + E I
Sbjct: 95 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE-- 152
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
L +LKK E+ +LE+ K + E + +Q + I EL+ ++A+ E L
Sbjct: 153 -LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ--IAELKMQLAKKEE---EL 206
Query: 493 QRELAEANSKFTGSNPSLMKVPQPE-TVKVSRSSLTRGGSQEDPAQ-LLRDLQDSLEREA 550
Q LA + + N +L K+ + E + + L + + A+ RDL + LE
Sbjct: 207 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA-- 264
Query: 551 DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
L+ +L + + TA +++ + V+ + + ET + H A
Sbjct: 265 -LKTELEDTLDSTATQQELRAKREQEVTVLKKAL------DEETRS--------HEAQVQ 309
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
++K ++++ TE+ L F A NL K +E++N L +L+
Sbjct: 310 EMRQKHAQ---AVEELTEQ---------LEQFKRAKA-NLDKNKQTLEKENADLAGELRV 356
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ K KL + + E AE+ + + E + + E
Sbjct: 357 LG----QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 412
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
E L K V L+S++ T+ T + +++T +L EER L+D++DE
Sbjct: 413 AEGKAIKLAKDVASLSSQLQD-TQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEM 470
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
+ ER L+ +LS ++KK + + +++A ++ +++++ + Q+ A
Sbjct: 471 EAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAA 528
Query: 851 TQSLEADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEM 909
LE +LQ E L + L N + L S+ L+ +K QL E K +K +
Sbjct: 529 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERD 586
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
+ E EK+ + + + L++K+ L S KDD
Sbjct: 587 RAEAEAREKETKALSLARALEEALEAKE--------ELERTNKMLKAEMEDLVSSKDDVG 638
Query: 970 KSFKPRIPKKPTDLTTKL-QLKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKL 1023
K+ + K L T++ ++K +E+LE E+ ++ + + L G+
Sbjct: 639 KNVH-ELEKSKRALETQMEEMKTQLEELEDELQASEDAKLRLEVNMQALKGQFERDLQAR 697
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
+++ +E R +L + E+ E + E A KLEGD K LE + +
Sbjct: 698 DEQNEEKRRQLQRQLHEYETELEDERNERALAAAAKKKLEGD-------LKDLELQADSA 750
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
+ ++++ +AQ+ +L++A + + +
Sbjct: 751 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 810
Query: 1144 XQVDNYTK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXX 1202
+ K D +K +L +E+ ++E++L + +
Sbjct: 811 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 870
Query: 1203 XXXXXXXXQAVVLAN---THRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYE 1259
QA L+N T R + + S + +L+ + + SK +E +K+ ++
Sbjct: 871 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA---VKSKFK 927
Query: 1260 NKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQD 1319
+ I +LE+ IA + ++Q E +Q + ++ + ++ Q
Sbjct: 928 STIAALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 986
Query: 1320 ELNNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
E NA++K LE+ E ES +L+ +L
Sbjct: 987 EKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1021
Score = 97.9 bits (233), Expect = 3e-19
Identities = 187/935 (20%), Positives = 391/935 (41%), Gaps = 63/935 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCE-RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+++E ++ E +Q++ + + E +++K + +IL+ D NK S E L+
Sbjct: 68 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD----DQNNKL----SKERKLLE 119
Query: 324 QKVNELTTHNEDLRDEKKHLTQ---KIREIESELETRPSTEAQTRQ-IEQLRAKLLA-AE 378
+++++LTT+ + ++ K+LT+ K + SELE R E ++RQ +E+L+ KL A
Sbjct: 120 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 179
Query: 379 TLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR--RELEQTIKNCRV 433
E++ D + ++K +L ++ A + ++L+ RELE I + +
Sbjct: 180 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 239
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL---LEIVGGPDGMQRENRIKELEQEVA---RSTE 487
+ KA++ +++ E + L LE Q+E R K EQEV ++ +
Sbjct: 240 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALD 298
Query: 488 VALRL-QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQD 544
R + ++ E K + L + Q E K ++++L + +++ A L +L+
Sbjct: 299 EETRSHEAQVQEMRQKHAQAVEELTE--QLEQFKRAKANLDKNKQTLEKENADLAGELRV 356
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT---NSIQN 601
+ + ++ + + E + + + + D + +E E+VT N +
Sbjct: 357 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEG 415
Query: 602 KMIHAASTPSS--KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL-RKTAARVE 658
K I A +S + D+ L ++T ++ L L + + L + A+
Sbjct: 416 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 475
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPA---NKLSIETANDNDEKETDEADPAEMKLLLE 715
+ L ++ +K + + + T A K + +N ++ +E A KL
Sbjct: 476 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL--- 532
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E+ L++++++L D + ++ V L K + A + + A
Sbjct: 533 --EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 590
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E R K E + + + L E E L + + + + L+ S+ D + +L++
Sbjct: 591 EAREK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEK 646
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+ +E + + KTQ E ++E +E+ KL+L N ++L+ DL + Q E
Sbjct: 647 SKRALETQMEEM--KTQLEELEDELQASEDAKLRLEVNMQALKGQFERDLQARDE-QNEE 703
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
+ ++ ++ E E +DE++E+ + K E D LK +
Sbjct: 704 KRRQLQRQLHEYETELEDERNERALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR 762
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK 1015
QA +K D Q+ + + T + +K + LE ++ ++ + A + K
Sbjct: 763 KLQAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 818
Query: 1016 EMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
+ A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 819 Q--ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 875
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXX 1135
+ LSN+ T + E+ +L K S M +
Sbjct: 876 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAAL 933
Query: 1136 XXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 934 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 968
Score = 85.4 bits (202), Expect = 2e-15
Identities = 183/1035 (17%), Positives = 374/1035 (36%), Gaps = 68/1035 (6%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE 841
LE+ + E+ +L E+E ++L AE +KK + +++ K QL+ +
Sbjct: 34 LEEILHEMEARLEEEEDRGQQLQAE----RKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 89
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
EA + + + + L D++ NK L + L ++ DL T + E
Sbjct: 90 AEAKIKKLEDEILVMDDQ----NNK----LSKERKLLEERISDLTTNLAEEEEKAKNLTK 141
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
K K MI + E KK E +++E + LK K A L
Sbjct: 142 LKNKHESMISELEVRLKK---EEKSRQELEKLKRKLEGDASDFHEQIADLQAQI---AEL 195
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKT 1021
K ++ + + + ++ K K + +LE I ++ + + E A+
Sbjct: 196 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS------ERAARN 249
Query: 1022 KLEKEIDEIRSKLS--KNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K EK+ ++ +L K + E T + Q E+ ++ + K + ++ E +
Sbjct: 250 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL--KKALDEETRSHEAQ 307
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
+ + EE+ + Q + A+L KN +L+ +D
Sbjct: 308 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 367
Query: 1139 XXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK----RIEKQLSTR 1194
QV D + E+ DK K+ + + ++ K +++
Sbjct: 368 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 427
Query: 1195 KDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARF---IKTESKFITLEAEM 1251
++ Q + ++ R+L E S +D+L E TL ++
Sbjct: 428 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 487
Query: 1252 RDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXX 1311
D K K+ ST+ A + K+ + + T ++A + ++ + +
Sbjct: 488 SDSK----KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 543
Query: 1312 XXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSS 1371
D LEK + + E + S A + +
Sbjct: 544 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 603
Query: 1372 YWENKAKELDTDLQSERK--KLDRMRIAHDKDVKNKDA-ELATLKGKLKILEQNSGAGAK 1428
+A E +L+ K K + + KD K+ EL K L+ + +
Sbjct: 604 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 663
Query: 1429 RITELKQEYEETVKKLEHSLALEKAEYE-ELTGKYELLEEEHVVTKARL---TVEKEQAQ 1484
+ + Q E+ +LE ++ K ++E +L + E EE+ + +L E E +
Sbjct: 664 ELEDELQASEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 723
Query: 1485 GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERAR 1544
E G++K L+ L +SA E+ Q + LQ ++ E+E AR
Sbjct: 724 NERALAAAAKKKLEGDLKDLE--LQADSAIKGREEAIKQ--LRKLQAQMKDFQRELEDAR 779
Query: 1545 LNAR---LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXX 1601
+ +E E +A + D+++ D + + +++
Sbjct: 780 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA---------RKQADLEKEELAEE 830
Query: 1602 XXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNY 1661
++ +AR A++ + +G M M D ++ Q + E
Sbjct: 831 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 890
Query: 1662 KQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDEL-CESRL 1720
+ + + + +++ +K R + + + ++++ +A LE ++A LE+++ E+R
Sbjct: 891 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 950
Query: 1721 LASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDE 1780
+ + +K E+ L R + + G ARV L ++E A +E
Sbjct: 951 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA----EEE 1006
Query: 1781 QQRLLQETSTLARDL 1795
QR+ L R+L
Sbjct: 1007 SQRINANRRKLQREL 1021
Score = 64.9 bits (151), Expect = 3e-09
Identities = 101/510 (19%), Positives = 210/510 (41%), Gaps = 37/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 540 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 597
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 598 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 657
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + E
Sbjct: 658 MKTQLEELEDELQASEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 717
Query: 444 KADQLEQEKA---------EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ + E+A E + K LE+ RE IK+L + A+ + L+
Sbjct: 718 ELEDERNERALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 777
Query: 495 ELAEANSKFTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 778 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 837
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 838 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 896
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
S++++ + + E + + S + A + + +VE++
Sbjct: 897 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 955
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 956 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 1012
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKI 749
L+R+++E + EA+ ++V L SK+
Sbjct: 1013 NRRKLQRELDEATESNEAMGREVNALKSKL 1042
Score = 58.4 bits (135), Expect = 2e-07
Identities = 111/625 (17%), Positives = 250/625 (40%), Gaps = 26/625 (4%)
Query: 262 VDSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKS--DILLRRLANIDTANKYTTGRSSE 318
+ S +++ Q+ + E +Q++++ K + E+ S D L + ++ + + +
Sbjct: 427 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 486
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST----EAQTRQIEQLRAKL 374
+ ++K+ + + E L + KK ++I + + E + + E +++Q L
Sbjct: 487 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 546
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +L+ E +++ L + N ADE E + L
Sbjct: 547 VVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL 602
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR-LQ 493
+ L++ ++LE+ + ++ ++V D + + + ELE+ R+ E + ++
Sbjct: 603 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHELEKS-KRALETQMEEMK 659
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL-EREADL 552
+L E + S + +++ + E + R LQ L E E +L
Sbjct: 660 TQLEELEDELQASEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 719
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ RN A K+ D ++ D+ + E+ +Q +M
Sbjct: 720 EDE-RNERALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQRELED 777
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--ESLLLQLK- 669
S + K E+ + + + +AA + A +E++ E L L
Sbjct: 778 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 837
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
+ A + R+L + +E N E +D A + +L+ + AT R +
Sbjct: 838 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNELATE-RSTAQ 895
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
+ E ++ L++Q KEL SK+ + + +L +L EE+V+ E
Sbjct: 896 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQAA 954
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
K L +K++ + + ++ ++K K ++ + + + LKRQL+ E+E+ + A
Sbjct: 955 TKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQLKRQLEEAEEESQRINA 1012
Query: 850 KTQSLEADNEKLQTENKKLQLLKNA 874
+ L+ + ++ N+ + NA
Sbjct: 1013 NRRKLQRELDEATESNEAMGREVNA 1037
Score = 46.4 bits (105), Expect = 0.001
Identities = 48/234 (20%), Positives = 105/234 (44%), Gaps = 12/234 (5%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL 343
RK+ + ++E ++ L L+ + + + +L++++ E + E + D +
Sbjct: 817 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 876
Query: 344 TQKIREIESELETRPST----EAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLX 399
TQ+ ++ +EL T ST E+ +Q+E+ +L + E + K + L
Sbjct: 877 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALE 934
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ--EKAEHEK 457
+++ E +A E + + L+Q K + + +++ + A+Q ++ EK
Sbjct: 935 AKIAQLEEQV-EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 993
Query: 458 KLL--EIVGGPDGMQREN-RIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
K L ++ + QR N ++L++E+ +TE + RE+ SK G P
Sbjct: 994 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1047
>BC104906-1|AAI04907.1| 1938|Homo sapiens myosin, heavy chain 11,
smooth muscle protein.
Length = 1938
Score = 113 bits (273), Expect = 5e-24
Identities = 226/1115 (20%), Positives = 441/1115 (39%), Gaps = 94/1115 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
Q E ++ + D L+K ER +K +++ L ++ + T + + + Q EL
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 332 HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL-CEELMDENED 390
E++R Q++ EI E+E R E Q Q K +A + L EE ++E E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 391 MKKELR----DLXXXXXXMQDNF--REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++L+ ++D +DQ ++ S R+ LE+ I + L+ L + E K
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD---LTTNLAEEEEK 1021
Query: 445 ADQLEQEKAEHEKKL--LEIVGGPDGMQRENRIK---ELEQEVARSTEVALRLQRELAEA 499
A L + K +HE + LE+ + R+ K +LE + + E LQ ++AE
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR----EQ 555
+ L ++++ + +E + DLQ+ L+ E R +Q
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI-SDLQEDLDSERAARNKAEKQ 1140
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM-IHAASTPSSKE 614
R+ EE K T LD + E + ++ + H A ++
Sbjct: 1141 KRDLGEELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
K ++++ TE+ L F AN L K +E++N L +L+ +
Sbjct: 1200 KHAQ---AVEELTEQ---------LEQFKRAKAN-LDKNKQTLEKENADLAGELRVLG-- 1244
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
K KL + + E AE+ + + E + + E E
Sbjct: 1245 --QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L K V L+S++ T+ T + +++T +L EER L+D++DE +
Sbjct: 1303 AIKLAKDVASLSSQLQD-TQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQ 1360
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSL 854
ER L+ +LS ++KK + + +++A ++ +++++ + Q+ A L
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418
Query: 855 EADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQD 913
E +LQ E L + L N + L S+ L+ +K QL E K +K + +
Sbjct: 1419 EKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 914 EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFK 973
E EK+ + + + L++K+ L S KDD K+
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAE--------MEDLVSSKDDVGKNVH 1528
Query: 974 PRIPKKPTDLTTKLQ-LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEKEI 1027
+ K L T+++ +K +E+LE E+ ++ + + L G+ +++
Sbjct: 1529 -ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC 1087
+E R +L + E+ E + + A KLEGD K LE + +
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-------LKDLELQADSAIKGR 1640
Query: 1088 KTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
+ ++++ +AQ+ +L++A + + + +
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 1148 NYTK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXX 1206
K D +K +L +E+ ++E++L + +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 1207 XXXXQAVVLANTHRRLSIEL-TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSL 1265
QA L+N L+ E T++K+E + ++ ++K L +++ +++ ++K
Sbjct: 1761 KATQQAEQLSN---ELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKF--- 1812
Query: 1266 ESTIAAKDVHIKQLEDALRQTTNDKYDEATS------PVEMVEMRXXXXXXXXXXXXXQD 1319
+STIAA + I QLE+ + Q +K S ++ + ++ Q
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872
Query: 1320 ELNNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
E NA++K LE+ E ES +L+ +L
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Score = 97.9 bits (233), Expect = 3e-19
Identities = 187/935 (20%), Positives = 390/935 (41%), Gaps = 63/935 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCE-RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+++E ++ E +Q++ + + E +++K + +IL+ D NK S E L+
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD----DQNNKL----SKERKLLE 1005
Query: 324 QKVNELTTHNEDLRDEKKHLTQ---KIREIESELETRPSTEAQTRQ-IEQLRAKLLA-AE 378
+++++LTT+ + ++ K+LT+ K + SELE R E ++RQ +E+L+ KL A
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 379 TLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR--RELEQTIKNCRV 433
E++ D + ++K +L ++ A + ++L+ RELE I + +
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL---LEIVGGPDGMQRENRIKELEQEVA---RSTE 487
+ KA++ +++ E + L LE Q+E R K EQEV ++ +
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALD 1184
Query: 488 VALRL-QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQD 544
R + ++ E K + L + Q E K ++++L + +++ A L +L+
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTE--QLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT---NSIQN 601
+ + ++ + + E + + + + D + +E E+VT N +
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEG 1301
Query: 602 KMIHAASTPSS--KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL-RKTAARVE 658
K I A +S + D+ L ++T ++ L L + + L + A+
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPA---NKLSIETANDNDEKETDEADPAEMKLLLE 715
+ L ++ +K + + + T A K + +N ++ +E A KL
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL--- 1418
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E+ L++++++L D + ++ V L K + A + + A
Sbjct: 1419 --EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E R K E + + + L E E L + + + + L+ S+ D + +L++
Sbjct: 1477 EAREK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEK 1532
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+ +E + + KTQ E ++E TE+ KL+L N ++L+ DL + Q E
Sbjct: 1533 SKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEE 1589
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
+ ++ ++ E E +DE+ ++ + K E D LK +
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR 1648
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK 1015
QA +K D Q+ + + T + +K + LE ++ ++ + A + K
Sbjct: 1649 KLQAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 1016 EMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
+ A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 1705 Q--ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXX 1135
+ LSN+ T + E+ +L K S M +
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAAL 1819
Query: 1136 XXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Score = 74.9 bits (176), Expect = 3e-12
Identities = 146/775 (18%), Positives = 298/775 (38%), Gaps = 67/775 (8%)
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K + +K +E++ +L + S+ T EKN LQ ++ ++ A+ E + A K + LE
Sbjct: 865 KERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE- 922
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXX 1139
+ ++ + EE ++R Q L A+ K + + +
Sbjct: 923 ---ILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 1140 XXXXXQV-DNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ D +D NKL KE ++I D K + K + + +
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + V + EL K +L+ + L+A++ +LK
Sbjct: 1037 S-----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
K L++ +A D I Q +AL++ + + ++ R
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
+EL K +LE T +S+A + E+ A+ + ++ L+ +A
Sbjct: 1146 EELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E +L + ++ R + DK+ + + E A L G+L++L G + + K++
Sbjct: 1205 VE---ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKL 1257
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
E V++L+ + + EL K L+ E L +A+G+ + + K++++
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN----EAEGKAIKLAKDVASL 1313
Query: 1498 LGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELR 1557
+++ QE L E+ +K + + L+E ER N+ DQ + E+
Sbjct: 1314 SSQLQDTQELLQEETR----QKLNVSTKLRQLEE---------ER---NSLQDQLDEEME 1357
Query: 1558 AANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQ 1617
A + LE H D+ S ++ E+
Sbjct: 1358 AKQN----LERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEK 1411
Query: 1618 SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AA 1668
+ K E TK R + +++ + +L + VS +++ + Q+L A
Sbjct: 1412 AAAYDKLE--KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
++ AE + +K + + + + E + ++ + + ++L S+ K E
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQR 1783
L K + E ++ EM+++L E E+E L ++ A++ L ERD Q R
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQALKGQFERDLQAR 1583
Score = 64.5 bits (150), Expect = 4e-09
Identities = 100/510 (19%), Positives = 211/510 (41%), Gaps = 37/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 1483
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + E
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 444 KADQLEQEKA---------EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ + +++A E + K LE+ RE IK+L + A+ + L+
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 495 ELAEANSKFTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 1782
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
S++++ + + E + + S + A + + +VE++
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 1841
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKI 749
L+R+++E + EA+ ++V L SK+
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 62.9 bits (146), Expect = 1e-08
Identities = 170/935 (18%), Positives = 339/935 (36%), Gaps = 55/935 (5%)
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKEL---EMICQDEKSEKKVRFT 923
LQ+ + + +++ + TK+ Q ENELKE K +L + + Q++ + +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
EA + KQ Q K AQ+ + +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 984 TT-KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-- 1040
KLQL+K+ + + + E +++ + + K + LE+ I ++ + L++ + +
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMD-DQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 1041 -FTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
T KN+ ++ I++L+ K E + + LE + S+ Q L ++ +
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 1100 QINKLSADLKNATS-LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNK 1158
Q+ K +L+ A + L ++ + K ++ K
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 1159 LLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANT 1218
L +E+ ++ D + E++++ K + Q +
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA---QVQEMRQK 1200
Query: 1219 HRRLSIELTSEKDELQARFIKTESKFITLEAEMRDL----------KADYENKITSLEST 1268
H + ELT + ++ + + TLE E DL K + E+K LE+
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 1269 IAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
+ E A R NDK + + VE V ++ + +L
Sbjct: 1261 VQELQSKCSDGERA-RAELNDKVHKLQNEVESVT--GMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
+ T+ + + + L +LE E L+ L +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG---AKRITELKQEYEETVKKLE 1445
KKL + + K ++ + E+ + A K L+QE ++ V L+
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 1446 HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
+ L + E+ K++ L E ++ E+++A+ E +KE + AL + L+
Sbjct: 1438 NQRQLV-SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR--EKE-TKALSLARALE 1493
Query: 1506 EKLGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
E L + T K EM++ ++S ++ + E+E+++ A Q E +
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSK-RALETQMEEMKTQLEEL 1551
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
D L+ D +ER + + + E+ +
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 1623 KAEITDTKTRYEGQMNTMR----DELKSLHNQVSRFRR---ERDNYKQMLEAAQKSMAEI 1675
+A K + EG + + +K + + R+ + ++++ LE A+ S EI
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 1676 ----KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLN--TEL 1729
K +K A+ + E+ + A +Q ++EL E LAS L+ L
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEE--LASSLSGRNAL 1727
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
EK E R+A+++ L E + S R R A
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Score = 57.2 bits (132), Expect = 6e-07
Identities = 121/610 (19%), Positives = 237/610 (38%), Gaps = 56/610 (9%)
Query: 1224 IELTSEKDELQAR---FIKTESKFITLEAEMRDLKADY----ENKITSLESTIAAKDVHI 1276
+++T +++E+QA+ KT+ + E E+++L+ + E K E A +++
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 1277 KQLEDALRQTTN-DKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+ E +R + +E +E + E ++ + + +LE+ EA
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+LE ++ + KLE+ E + +L T+L E +K
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 1394 MRIAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ +KNK ++ ++ L+ +LK E++ + + +LK++ E +A +
Sbjct: 1025 LT-----KLKNKHESMISELEVRLKKEEKSR----QELEKLKRKLEGDASDFHEQIADLQ 1075
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTES 1512
A+ EL + EEE ARL E Q L K++ G I LQE L +E
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1131
Query: 1513 AAWN---TEKTEMQNSIASLQERLCGG-GWEVERARLNARLDQRERELRAANDRRDVLEH 1568
AA N +K ++ + +L+ L + L A+ +Q L+ A D + H
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSH 1190
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE--KARKAEI 1626
E++ + +R + K E+
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 1627 TDTKTRYEGQMNTMRDELK-------SLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGD 1679
K + E Q+ ++ + L+++V + + E ++ ML A+ ++
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 1680 KSARIHRNSISSTDEEEYRNKVAL------LEQQVACLEDELCESRLLASKLNTELVSEK 1733
S +EE R K+ + LE++ L+D+L E + +K N E
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE--MEAKQNLE--RHI 1366
Query: 1734 SSAEVRLAEMQSRLNEYEEE-RLLSSGRAR----VAGLATRME---LAWHKERDEQQRLL 1785
S+ ++L++ + +L ++ L G+ R + L + E A+ K + RL
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 1786 QETSTLARDL 1795
QE L DL
Sbjct: 1427 QELDDLVVDL 1436
Score = 54.8 bits (126), Expect = 3e-06
Identities = 109/625 (17%), Positives = 249/625 (39%), Gaps = 26/625 (4%)
Query: 262 VDSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKS--DILLRRLANIDTANKYTTGRSSE 318
+ S +++ Q+ + E +Q++++ K + E+ S D L + ++ + + +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST----EAQTRQIEQLRAKL 374
+ ++K+ + + E L + KK ++I + + E + + E +++Q L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +L+ E +++ L + N ADE E + L
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL 1488
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR-LQ 493
+ L++ ++LE+ + ++ ++V D + + + ELE+ R+ E + ++
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHELEKS-KRALETQMEEMK 1545
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL-EREADL 552
+L E + + + +++ + E + R LQ L E E +L
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ R A K+ D ++ D+ + E+ +Q +M
Sbjct: 1606 EDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQRELED 1663
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--ESLLLQLK- 669
S + K E+ + + + +AA + A +E++ E L L
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
+ A + R+L + +E N E +D A + +L+ + AT R +
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNELATE-RSTAQ 1781
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
+ E ++ L++Q KEL SK+ + + +L +L EE+V+ E
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQAA 1840
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
K L +K++ + + ++ ++K K ++ + + + LKRQL+ E+E+ + A
Sbjct: 1841 TKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 850 KTQSLEADNEKLQTENKKLQLLKNA 874
+ L+ + ++ N+ + NA
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNA 1923
Score = 46.4 bits (105), Expect = 0.001
Identities = 48/234 (20%), Positives = 105/234 (44%), Gaps = 12/234 (5%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL 343
RK+ + ++E ++ L L+ + + + +L++++ E + E + D +
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 344 TQKIREIESELETRPST----EAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLX 399
TQ+ ++ +EL T ST E+ +Q+E+ +L + E + K + L
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALE 1820
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ--EKAEHEK 457
+++ E +A E + + L+Q K + + +++ + A+Q ++ EK
Sbjct: 1821 AKIAQLEEQV-EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 458 KLL--EIVGGPDGMQREN-RIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
K L ++ + QR N ++L++E+ +TE + RE+ SK G P
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933
>BC101677-1|AAI01678.1| 1938|Homo sapiens myosin, heavy chain 11,
smooth muscle protein.
Length = 1938
Score = 113 bits (273), Expect = 5e-24
Identities = 226/1115 (20%), Positives = 441/1115 (39%), Gaps = 94/1115 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
Q E ++ + D L+K ER +K +++ L ++ + T + + + Q EL
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 332 HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL-CEELMDENED 390
E++R Q++ EI E+E R E Q Q K +A + L EE ++E E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 391 MKKELR----DLXXXXXXMQDNF--REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++L+ ++D +DQ ++ S R+ LE+ I + L+ L + E K
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD---LTTNLAEEEEK 1021
Query: 445 ADQLEQEKAEHEKKL--LEIVGGPDGMQRENRIK---ELEQEVARSTEVALRLQRELAEA 499
A L + K +HE + LE+ + R+ K +LE + + E LQ ++AE
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR----EQ 555
+ L ++++ + +E + DLQ+ L+ E R +Q
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI-SDLQEDLDSERAARNKAEKQ 1140
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM-IHAASTPSSKE 614
R+ EE K T LD + E + ++ + H A ++
Sbjct: 1141 KRDLGEELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
K ++++ TE+ L F AN L K +E++N L +L+ +
Sbjct: 1200 KHAQ---AVEELTEQ---------LEQFKRAKAN-LDKNKQTLEKENADLAGELRVLG-- 1244
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
K KL + + E AE+ + + E + + E E
Sbjct: 1245 --QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L K V L+S++ T+ T + +++T +L EER L+D++DE +
Sbjct: 1303 AIKLAKDVASLSSQLQD-TQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQ 1360
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSL 854
ER L+ +LS ++KK + + +++A ++ +++++ + Q+ A L
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418
Query: 855 EADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQD 913
E +LQ E L + L N + L S+ L+ +K QL E K +K + +
Sbjct: 1419 EKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 914 EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFK 973
E EK+ + + + L++K+ L S KDD K+
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAE--------MEDLVSSKDDVGKNVH 1528
Query: 974 PRIPKKPTDLTTKLQ-LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEKEI 1027
+ K L T+++ +K +E+LE E+ ++ + + L G+ +++
Sbjct: 1529 -ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC 1087
+E R +L + E+ E + + A KLEGD K LE + +
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-------LKDLELQADSAIKGR 1640
Query: 1088 KTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
+ ++++ +AQ+ +L++A + + + +
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 1148 NYTK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXX 1206
K D +K +L +E+ ++E++L + +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 1207 XXXXQAVVLANTHRRLSIEL-TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSL 1265
QA L+N L+ E T++K+E + ++ ++K L +++ +++ ++K
Sbjct: 1761 KATQQAEQLSN---ELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKF--- 1812
Query: 1266 ESTIAAKDVHIKQLEDALRQTTNDKYDEATS------PVEMVEMRXXXXXXXXXXXXXQD 1319
+STIAA + I QLE+ + Q +K S ++ + ++ Q
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872
Query: 1320 ELNNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
E NA++K LE+ E ES +L+ +L
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Score = 97.9 bits (233), Expect = 3e-19
Identities = 187/935 (20%), Positives = 390/935 (41%), Gaps = 63/935 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCE-RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+++E ++ E +Q++ + + E +++K + +IL+ D NK S E L+
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD----DQNNKL----SKERKLLE 1005
Query: 324 QKVNELTTHNEDLRDEKKHLTQ---KIREIESELETRPSTEAQTRQ-IEQLRAKLLA-AE 378
+++++LTT+ + ++ K+LT+ K + SELE R E ++RQ +E+L+ KL A
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 379 TLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR--RELEQTIKNCRV 433
E++ D + ++K +L ++ A + ++L+ RELE I + +
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL---LEIVGGPDGMQRENRIKELEQEVA---RSTE 487
+ KA++ +++ E + L LE Q+E R K EQEV ++ +
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALD 1184
Query: 488 VALRL-QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQD 544
R + ++ E K + L + Q E K ++++L + +++ A L +L+
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTE--QLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT---NSIQN 601
+ + ++ + + E + + + + D + +E E+VT N +
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEG 1301
Query: 602 KMIHAASTPSS--KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL-RKTAARVE 658
K I A +S + D+ L ++T ++ L L + + L + A+
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPA---NKLSIETANDNDEKETDEADPAEMKLLLE 715
+ L ++ +K + + + T A K + +N ++ +E A KL
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL--- 1418
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E+ L++++++L D + ++ V L K + A + + A
Sbjct: 1419 --EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E R K E + + + L E E L + + + + L+ S+ D + +L++
Sbjct: 1477 EAREK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEK 1532
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+ +E + + KTQ E ++E TE+ KL+L N ++L+ DL + Q E
Sbjct: 1533 SKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEE 1589
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
+ ++ ++ E E +DE+ ++ + K E D LK +
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR 1648
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK 1015
QA +K D Q+ + + T + +K + LE ++ ++ + A + K
Sbjct: 1649 KLQAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 1016 EMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
+ A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 1705 Q--ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXX 1135
+ LSN+ T + E+ +L K S M +
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAAL 1819
Query: 1136 XXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Score = 74.9 bits (176), Expect = 3e-12
Identities = 146/775 (18%), Positives = 298/775 (38%), Gaps = 67/775 (8%)
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K + +K +E++ +L + S+ T EKN LQ ++ ++ A+ E + A K + LE
Sbjct: 865 KERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE- 922
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXX 1139
+ ++ + EE ++R Q L A+ K + + +
Sbjct: 923 ---ILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 1140 XXXXXQV-DNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ D +D NKL KE ++I D K + K + + +
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + V + EL K +L+ + L+A++ +LK
Sbjct: 1037 S-----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
K L++ +A D I Q +AL++ + + ++ R
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
+EL K +LE T +S+A + E+ A+ + ++ L+ +A
Sbjct: 1146 EELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E +L + ++ R + DK+ + + E A L G+L++L G + + K++
Sbjct: 1205 VE---ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKL 1257
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
E V++L+ + + EL K L+ E L +A+G+ + + K++++
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN----EAEGKAIKLAKDVASL 1313
Query: 1498 LGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELR 1557
+++ QE L E+ +K + + L+E ER N+ DQ + E+
Sbjct: 1314 SSQLQDTQELLQEETR----QKLNVSTKLRQLEE---------ER---NSLQDQLDEEME 1357
Query: 1558 AANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQ 1617
A + LE H D+ S ++ E+
Sbjct: 1358 AKQN----LERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEK 1411
Query: 1618 SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AA 1668
+ K E TK R + +++ + +L + VS +++ + Q+L A
Sbjct: 1412 AAAYDKLE--KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
++ AE + +K + + + + E + ++ + + ++L S+ K E
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQR 1783
L K + E ++ EM+++L E E+E L ++ A++ L ERD Q R
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQALKGQFERDLQAR 1583
Score = 64.5 bits (150), Expect = 4e-09
Identities = 100/510 (19%), Positives = 211/510 (41%), Gaps = 37/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 1483
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + E
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 444 KADQLEQEKA---------EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ + +++A E + K LE+ RE IK+L + A+ + L+
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 495 ELAEANSKFTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 1782
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
S++++ + + E + + S + A + + +VE++
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 1841
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKI 749
L+R+++E + EA+ ++V L SK+
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 62.9 bits (146), Expect = 1e-08
Identities = 170/935 (18%), Positives = 339/935 (36%), Gaps = 55/935 (5%)
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKEL---EMICQDEKSEKKVRFT 923
LQ+ + + +++ + TK+ Q ENELKE K +L + + Q++ + +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
EA + KQ Q K AQ+ + +
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 984 TT-KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-- 1040
KLQL+K+ + + + E +++ + + K + LE+ I ++ + L++ + +
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMD-DQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 1041 -FTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
T KN+ ++ I++L+ K E + + LE + S+ Q L ++ +
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 1100 QINKLSADLKNATS-LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNK 1158
Q+ K +L+ A + L ++ + K ++ K
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 1159 LLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANT 1218
L +E+ ++ D + E++++ K + Q +
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA---QVQEMRQK 1200
Query: 1219 HRRLSIELTSEKDELQARFIKTESKFITLEAEMRDL----------KADYENKITSLEST 1268
H + ELT + ++ + + TLE E DL K + E+K LE+
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 1269 IAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
+ E A R NDK + + VE V ++ + +L
Sbjct: 1261 VQELQSKCSDGERA-RAELNDKVHKLQNEVESVT--GMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
+ T+ + + + L +LE E L+ L +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG---AKRITELKQEYEETVKKLE 1445
KKL + + K ++ + E+ + A K L+QE ++ V L+
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 1446 HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
+ L + E+ K++ L E ++ E+++A+ E +KE + AL + L+
Sbjct: 1438 NQRQLV-SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR--EKE-TKALSLARALE 1493
Query: 1506 EKLGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
E L + T K EM++ ++S ++ + E+E+++ A Q E +
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSK-RALETQMEEMKTQLEEL 1551
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
D L+ D +ER + + + E+ +
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 1623 KAEITDTKTRYEGQMNTMR----DELKSLHNQVSRFRR---ERDNYKQMLEAAQKSMAEI 1675
+A K + EG + + +K + + R+ + ++++ LE A+ S EI
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 1676 ----KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLN--TEL 1729
K +K A+ + E+ + A +Q ++EL E LAS L+ L
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEE--LASSLSGRNAL 1727
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
EK E R+A+++ L E + S R R A
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Score = 57.2 bits (132), Expect = 6e-07
Identities = 121/610 (19%), Positives = 237/610 (38%), Gaps = 56/610 (9%)
Query: 1224 IELTSEKDELQAR---FIKTESKFITLEAEMRDLKADY----ENKITSLESTIAAKDVHI 1276
+++T +++E+QA+ KT+ + E E+++L+ + E K E A +++
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 1277 KQLEDALRQTTN-DKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+ E +R + +E +E + E ++ + + +LE+ EA
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+LE ++ + KLE+ E + +L T+L E +K
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 1394 MRIAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ +KNK ++ ++ L+ +LK E++ + + +LK++ E +A +
Sbjct: 1025 LT-----KLKNKHESMISELEVRLKKEEKSR----QELEKLKRKLEGDASDFHEQIADLQ 1075
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTES 1512
A+ EL + EEE ARL E Q L K++ G I LQE L +E
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1131
Query: 1513 AAWN---TEKTEMQNSIASLQERLCGG-GWEVERARLNARLDQRERELRAANDRRDVLEH 1568
AA N +K ++ + +L+ L + L A+ +Q L+ A D + H
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSH 1190
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE--KARKAEI 1626
E++ + +R + K E+
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 1627 TDTKTRYEGQMNTMRDELK-------SLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGD 1679
K + E Q+ ++ + L+++V + + E ++ ML A+ ++
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 1680 KSARIHRNSISSTDEEEYRNKVAL------LEQQVACLEDELCESRLLASKLNTELVSEK 1733
S +EE R K+ + LE++ L+D+L E + +K N E
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE--MEAKQNLE--RHI 1366
Query: 1734 SSAEVRLAEMQSRLNEYEEE-RLLSSGRAR----VAGLATRME---LAWHKERDEQQRLL 1785
S+ ++L++ + +L ++ L G+ R + L + E A+ K + RL
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 1786 QETSTLARDL 1795
QE L DL
Sbjct: 1427 QELDDLVVDL 1436
Score = 54.8 bits (126), Expect = 3e-06
Identities = 109/625 (17%), Positives = 249/625 (39%), Gaps = 26/625 (4%)
Query: 262 VDSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKS--DILLRRLANIDTANKYTTGRSSE 318
+ S +++ Q+ + E +Q++++ K + E+ S D L + ++ + + +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST----EAQTRQIEQLRAKL 374
+ ++K+ + + E L + KK ++I + + E + + E +++Q L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +L+ E +++ L + N ADE E + L
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL 1488
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR-LQ 493
+ L++ ++LE+ + ++ ++V D + + + ELE+ R+ E + ++
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHELEKS-KRALETQMEEMK 1545
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL-EREADL 552
+L E + + + +++ + E + R LQ L E E +L
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ R A K+ D ++ D+ + E+ +Q +M
Sbjct: 1606 EDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQRELED 1663
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--ESLLLQLK- 669
S + K E+ + + + +AA + A +E++ E L L
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
+ A + R+L + +E N E +D A + +L+ + AT R +
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNELATE-RSTAQ 1781
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
+ E ++ L++Q KEL SK+ + + +L +L EE+V+ E
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQAA 1840
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
K L +K++ + + ++ ++K K ++ + + + LKRQL+ E+E+ + A
Sbjct: 1841 TKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 850 KTQSLEADNEKLQTENKKLQLLKNA 874
+ L+ + ++ N+ + NA
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNA 1923
Score = 46.4 bits (105), Expect = 0.001
Identities = 48/234 (20%), Positives = 105/234 (44%), Gaps = 12/234 (5%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL 343
RK+ + ++E ++ L L+ + + + +L++++ E + E + D +
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 344 TQKIREIESELETRPST----EAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLX 399
TQ+ ++ +EL T ST E+ +Q+E+ +L + E + K + L
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALE 1820
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ--EKAEHEK 457
+++ E +A E + + L+Q K + + +++ + A+Q ++ EK
Sbjct: 1821 AKIAQLEEQV-EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 458 KLL--EIVGGPDGMQREN-RIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
K L ++ + QR N ++L++E+ +TE + RE+ SK G P
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933
>AY520817-1|AAS98911.1| 1945|Homo sapiens smooth muscle myosin heavy
chain isoform SM2 protein.
Length = 1945
Score = 113 bits (273), Expect = 5e-24
Identities = 226/1115 (20%), Positives = 441/1115 (39%), Gaps = 94/1115 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
Q E ++ + D L+K ER +K +++ L ++ + T + + + Q EL
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 332 HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL-CEELMDENED 390
E++R Q++ EI E+E R E Q Q K +A + L EE ++E E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 391 MKKELR----DLXXXXXXMQDNF--REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++L+ ++D +DQ ++ S R+ LE+ I + L+ L + E K
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD---LTTNLAEEEEK 1028
Query: 445 ADQLEQEKAEHEKKL--LEIVGGPDGMQRENRIK---ELEQEVARSTEVALRLQRELAEA 499
A L + K +HE + LE+ + R+ K +LE + + E LQ ++AE
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR----EQ 555
+ L ++++ + +E + DLQ+ L+ E R +Q
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI-SDLQEDLDSERAARNKAEKQ 1147
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM-IHAASTPSSKE 614
R+ EE K T LD + E + ++ + H A ++
Sbjct: 1148 KRDLGEELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
K ++++ TE+ L F AN L K +E++N L +L+ +
Sbjct: 1207 KHAQ---AVEELTEQ---------LEQFKRAKAN-LDKNKQTLEKENADLAGELRVLG-- 1251
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
K KL + + E AE+ + + E + + E E
Sbjct: 1252 --QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L K V L+S++ T+ T + +++T +L EER L+D++DE +
Sbjct: 1310 AIKLAKDVASLSSQLQD-TQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQ 1367
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSL 854
ER L+ +LS ++KK + + +++A ++ +++++ + Q+ A L
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425
Query: 855 EADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQD 913
E +LQ E L + L N + L S+ L+ +K QL E K +K + +
Sbjct: 1426 EKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 914 EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFK 973
E EK+ + + + L++K+ L S KDD K+
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAE--------MEDLVSSKDDVGKNVH 1535
Query: 974 PRIPKKPTDLTTKLQ-LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEKEI 1027
+ K L T+++ +K +E+LE E+ ++ + + L G+ +++
Sbjct: 1536 -ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC 1087
+E R +L + E+ E + + A KLEGD K LE + +
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-------LKDLELQADSAIKGR 1647
Query: 1088 KTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
+ ++++ +AQ+ +L++A + + + +
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 1148 NYTK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXX 1206
K D +K +L +E+ ++E++L + +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 1207 XXXXQAVVLANTHRRLSIEL-TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSL 1265
QA L+N L+ E T++K+E + ++ ++K L +++ +++ ++K
Sbjct: 1768 KATQQAEQLSN---ELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKF--- 1819
Query: 1266 ESTIAAKDVHIKQLEDALRQTTNDKYDEATS------PVEMVEMRXXXXXXXXXXXXXQD 1319
+STIAA + I QLE+ + Q +K S ++ + ++ Q
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879
Query: 1320 ELNNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
E NA++K LE+ E ES +L+ +L
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Score = 97.9 bits (233), Expect = 3e-19
Identities = 187/935 (20%), Positives = 390/935 (41%), Gaps = 63/935 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCE-RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+++E ++ E +Q++ + + E +++K + +IL+ D NK S E L+
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD----DQNNKL----SKERKLLE 1012
Query: 324 QKVNELTTHNEDLRDEKKHLTQ---KIREIESELETRPSTEAQTRQ-IEQLRAKLLA-AE 378
+++++LTT+ + ++ K+LT+ K + SELE R E ++RQ +E+L+ KL A
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 379 TLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR--RELEQTIKNCRV 433
E++ D + ++K +L ++ A + ++L+ RELE I + +
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL---LEIVGGPDGMQRENRIKELEQEVA---RSTE 487
+ KA++ +++ E + L LE Q+E R K EQEV ++ +
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALD 1191
Query: 488 VALRL-QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQD 544
R + ++ E K + L + Q E K ++++L + +++ A L +L+
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTE--QLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT---NSIQN 601
+ + ++ + + E + + + + D + +E E+VT N +
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEG 1308
Query: 602 KMIHAASTPSS--KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL-RKTAARVE 658
K I A +S + D+ L ++T ++ L L + + L + A+
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPA---NKLSIETANDNDEKETDEADPAEMKLLLE 715
+ L ++ +K + + + T A K + +N ++ +E A KL
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL--- 1425
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E+ L++++++L D + ++ V L K + A + + A
Sbjct: 1426 --EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E R K E + + + L E E L + + + + L+ S+ D + +L++
Sbjct: 1484 EAREK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEK 1539
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+ +E + + KTQ E ++E TE+ KL+L N ++L+ DL + Q E
Sbjct: 1540 SKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEE 1596
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
+ ++ ++ E E +DE+ ++ + K E D LK +
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR 1655
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK 1015
QA +K D Q+ + + T + +K + LE ++ ++ + A + K
Sbjct: 1656 KLQAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 1016 EMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
+ A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 1712 Q--ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXX 1135
+ LSN+ T + E+ +L K S M +
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAAL 1826
Query: 1136 XXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Score = 74.9 bits (176), Expect = 3e-12
Identities = 146/775 (18%), Positives = 298/775 (38%), Gaps = 67/775 (8%)
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K + +K +E++ +L + S+ T EKN LQ ++ ++ A+ E + A K + LE
Sbjct: 872 KERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE- 929
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXX 1139
+ ++ + EE ++R Q L A+ K + + +
Sbjct: 930 ---ILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 1140 XXXXXQV-DNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ D +D NKL KE ++I D K + K + + +
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + V + EL K +L+ + L+A++ +LK
Sbjct: 1044 S-----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
K L++ +A D I Q +AL++ + + ++ R
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
+EL K +LE T +S+A + E+ A+ + ++ L+ +A
Sbjct: 1153 EELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E +L + ++ R + DK+ + + E A L G+L++L G + + K++
Sbjct: 1212 VE---ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKL 1264
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
E V++L+ + + EL K L+ E L +A+G+ + + K++++
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN----EAEGKAIKLAKDVASL 1320
Query: 1498 LGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELR 1557
+++ QE L E+ +K + + L+E ER N+ DQ + E+
Sbjct: 1321 SSQLQDTQELLQEETR----QKLNVSTKLRQLEE---------ER---NSLQDQLDEEME 1364
Query: 1558 AANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQ 1617
A + LE H D+ S ++ E+
Sbjct: 1365 AKQN----LERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEK 1418
Query: 1618 SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AA 1668
+ K E TK R + +++ + +L + VS +++ + Q+L A
Sbjct: 1419 AAAYDKLE--KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
++ AE + +K + + + + E + ++ + + ++L S+ K E
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQR 1783
L K + E ++ EM+++L E E+E L ++ A++ L ERD Q R
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQALKGQFERDLQAR 1590
Score = 64.5 bits (150), Expect = 4e-09
Identities = 100/510 (19%), Positives = 211/510 (41%), Gaps = 37/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 1490
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + E
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 444 KADQLEQEKA---------EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ + +++A E + K LE+ RE IK+L + A+ + L+
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 495 ELAEANSKFTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 1789
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
S++++ + + E + + S + A + + +VE++
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 1848
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKI 749
L+R+++E + EA+ ++V L SK+
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 62.9 bits (146), Expect = 1e-08
Identities = 170/935 (18%), Positives = 339/935 (36%), Gaps = 55/935 (5%)
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKEL---EMICQDEKSEKKVRFT 923
LQ+ + + +++ + TK+ Q ENELKE K +L + + Q++ + +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
EA + KQ Q K AQ+ + +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 984 TT-KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-- 1040
KLQL+K+ + + + E +++ + + K + LE+ I ++ + L++ + +
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMD-DQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 1041 -FTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
T KN+ ++ I++L+ K E + + LE + S+ Q L ++ +
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 1100 QINKLSADLKNATS-LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNK 1158
Q+ K +L+ A + L ++ + K ++ K
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 1159 LLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANT 1218
L +E+ ++ D + E++++ K + Q +
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA---QVQEMRQK 1207
Query: 1219 HRRLSIELTSEKDELQARFIKTESKFITLEAEMRDL----------KADYENKITSLEST 1268
H + ELT + ++ + + TLE E DL K + E+K LE+
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 1269 IAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
+ E A R NDK + + VE V ++ + +L
Sbjct: 1268 VQELQSKCSDGERA-RAELNDKVHKLQNEVESVT--GMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
+ T+ + + + L +LE E L+ L +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG---AKRITELKQEYEETVKKLE 1445
KKL + + K ++ + E+ + A K L+QE ++ V L+
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 1446 HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
+ L + E+ K++ L E ++ E+++A+ E +KE + AL + L+
Sbjct: 1445 NQRQLV-SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR--EKE-TKALSLARALE 1500
Query: 1506 EKLGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
E L + T K EM++ ++S ++ + E+E+++ A Q E +
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSK-RALETQMEEMKTQLEEL 1558
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
D L+ D +ER + + + E+ +
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 1623 KAEITDTKTRYEGQMNTMR----DELKSLHNQVSRFRR---ERDNYKQMLEAAQKSMAEI 1675
+A K + EG + + +K + + R+ + ++++ LE A+ S EI
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 1676 ----KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLN--TEL 1729
K +K A+ + E+ + A +Q ++EL E LAS L+ L
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEE--LASSLSGRNAL 1734
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
EK E R+A+++ L E + S R R A
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Score = 57.2 bits (132), Expect = 6e-07
Identities = 121/610 (19%), Positives = 237/610 (38%), Gaps = 56/610 (9%)
Query: 1224 IELTSEKDELQAR---FIKTESKFITLEAEMRDLKADY----ENKITSLESTIAAKDVHI 1276
+++T +++E+QA+ KT+ + E E+++L+ + E K E A +++
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 1277 KQLEDALRQTTN-DKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+ E +R + +E +E + E ++ + + +LE+ EA
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+LE ++ + KLE+ E + +L T+L E +K
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 1394 MRIAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ +KNK ++ ++ L+ +LK E++ + + +LK++ E +A +
Sbjct: 1032 LT-----KLKNKHESMISELEVRLKKEEKSR----QELEKLKRKLEGDASDFHEQIADLQ 1082
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTES 1512
A+ EL + EEE ARL E Q L K++ G I LQE L +E
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1138
Query: 1513 AAWN---TEKTEMQNSIASLQERLCGG-GWEVERARLNARLDQRERELRAANDRRDVLEH 1568
AA N +K ++ + +L+ L + L A+ +Q L+ A D + H
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSH 1197
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE--KARKAEI 1626
E++ + +R + K E+
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 1627 TDTKTRYEGQMNTMRDELK-------SLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGD 1679
K + E Q+ ++ + L+++V + + E ++ ML A+ ++
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 1680 KSARIHRNSISSTDEEEYRNKVAL------LEQQVACLEDELCESRLLASKLNTELVSEK 1733
S +EE R K+ + LE++ L+D+L E + +K N E
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE--MEAKQNLE--RHI 1373
Query: 1734 SSAEVRLAEMQSRLNEYEEE-RLLSSGRAR----VAGLATRME---LAWHKERDEQQRLL 1785
S+ ++L++ + +L ++ L G+ R + L + E A+ K + RL
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 1786 QETSTLARDL 1795
QE L DL
Sbjct: 1434 QELDDLVVDL 1443
Score = 54.8 bits (126), Expect = 3e-06
Identities = 109/625 (17%), Positives = 249/625 (39%), Gaps = 26/625 (4%)
Query: 262 VDSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKS--DILLRRLANIDTANKYTTGRSSE 318
+ S +++ Q+ + E +Q++++ K + E+ S D L + ++ + + +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST----EAQTRQIEQLRAKL 374
+ ++K+ + + E L + KK ++I + + E + + E +++Q L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +L+ E +++ L + N ADE E + L
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL 1495
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR-LQ 493
+ L++ ++LE+ + ++ ++V D + + + ELE+ R+ E + ++
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHELEKS-KRALETQMEEMK 1552
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL-EREADL 552
+L E + + + +++ + E + R LQ L E E +L
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ R A K+ D ++ D+ + E+ +Q +M
Sbjct: 1613 EDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQRELED 1670
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--ESLLLQLK- 669
S + K E+ + + + +AA + A +E++ E L L
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
+ A + R+L + +E N E +D A + +L+ + AT R +
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNELATE-RSTAQ 1788
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
+ E ++ L++Q KEL SK+ + + +L +L EE+V+ E
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQAA 1847
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
K L +K++ + + ++ ++K K ++ + + + LKRQL+ E+E+ + A
Sbjct: 1848 TKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 850 KTQSLEADNEKLQTENKKLQLLKNA 874
+ L+ + ++ N+ + NA
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNA 1930
Score = 46.4 bits (105), Expect = 0.001
Identities = 48/234 (20%), Positives = 105/234 (44%), Gaps = 12/234 (5%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL 343
RK+ + ++E ++ L L+ + + + +L++++ E + E + D +
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 344 TQKIREIESELETRPST----EAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLX 399
TQ+ ++ +EL T ST E+ +Q+E+ +L + E + K + L
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALE 1827
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ--EKAEHEK 457
+++ E +A E + + L+Q K + + +++ + A+Q ++ EK
Sbjct: 1828 AKIAQLEEQV-EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 458 KLL--EIVGGPDGMQREN-RIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
K L ++ + QR N ++L++E+ +TE + RE+ SK G P
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940
>AY520816-1|AAS98910.1| 1979|Homo sapiens smooth muscle myosin heavy
chain isoform SM1 protein.
Length = 1979
Score = 113 bits (273), Expect = 5e-24
Identities = 226/1115 (20%), Positives = 441/1115 (39%), Gaps = 94/1115 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
Q E ++ + D L+K ER +K +++ L ++ + T + + + Q EL
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 332 HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL-CEELMDENED 390
E++R Q++ EI E+E R E Q Q K +A + L EE ++E E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 391 MKKELR----DLXXXXXXMQDNF--REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++L+ ++D +DQ ++ S R+ LE+ I + L+ L + E K
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD---LTTNLAEEEEK 1028
Query: 445 ADQLEQEKAEHEKKL--LEIVGGPDGMQRENRIK---ELEQEVARSTEVALRLQRELAEA 499
A L + K +HE + LE+ + R+ K +LE + + E LQ ++AE
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR----EQ 555
+ L ++++ + +E + DLQ+ L+ E R +Q
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI-SDLQEDLDSERAARNKAEKQ 1147
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM-IHAASTPSSKE 614
R+ EE K T LD + E + ++ + H A ++
Sbjct: 1148 KRDLGEELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
K ++++ TE+ L F AN L K +E++N L +L+ +
Sbjct: 1207 KHAQ---AVEELTEQ---------LEQFKRAKAN-LDKNKQTLEKENADLAGELRVLG-- 1251
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
K KL + + E AE+ + + E + + E E
Sbjct: 1252 --QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L K V L+S++ T+ T + +++T +L EER L+D++DE +
Sbjct: 1310 AIKLAKDVASLSSQLQD-TQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQ 1367
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSL 854
ER L+ +LS ++KK + + +++A ++ +++++ + Q+ A L
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425
Query: 855 EADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQD 913
E +LQ E L + L N + L S+ L+ +K QL E K +K + +
Sbjct: 1426 EKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 914 EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFK 973
E EK+ + + + L++K+ L S KDD K+
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAE--------MEDLVSSKDDVGKNVH 1535
Query: 974 PRIPKKPTDLTTKLQ-LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEKEI 1027
+ K L T+++ +K +E+LE E+ ++ + + L G+ +++
Sbjct: 1536 -ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC 1087
+E R +L + E+ E + + A KLEGD K LE + +
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-------LKDLELQADSAIKGR 1647
Query: 1088 KTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
+ ++++ +AQ+ +L++A + + + +
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 1148 NYTK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXX 1206
K D +K +L +E+ ++E++L + +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 1207 XXXXQAVVLANTHRRLSIEL-TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSL 1265
QA L+N L+ E T++K+E + ++ ++K L +++ +++ ++K
Sbjct: 1768 KATQQAEQLSN---ELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKF--- 1819
Query: 1266 ESTIAAKDVHIKQLEDALRQTTNDKYDEATS------PVEMVEMRXXXXXXXXXXXXXQD 1319
+STIAA + I QLE+ + Q +K S ++ + ++ Q
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879
Query: 1320 ELNNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
E NA++K LE+ E ES +L+ +L
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Score = 97.9 bits (233), Expect = 3e-19
Identities = 187/935 (20%), Positives = 390/935 (41%), Gaps = 63/935 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCE-RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+++E ++ E +Q++ + + E +++K + +IL+ D NK S E L+
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD----DQNNKL----SKERKLLE 1012
Query: 324 QKVNELTTHNEDLRDEKKHLTQ---KIREIESELETRPSTEAQTRQ-IEQLRAKLLA-AE 378
+++++LTT+ + ++ K+LT+ K + SELE R E ++RQ +E+L+ KL A
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 379 TLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR--RELEQTIKNCRV 433
E++ D + ++K +L ++ A + ++L+ RELE I + +
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL---LEIVGGPDGMQRENRIKELEQEVA---RSTE 487
+ KA++ +++ E + L LE Q+E R K EQEV ++ +
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALD 1191
Query: 488 VALRL-QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQD 544
R + ++ E K + L + Q E K ++++L + +++ A L +L+
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTE--QLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT---NSIQN 601
+ + ++ + + E + + + + D + +E E+VT N +
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEG 1308
Query: 602 KMIHAASTPSS--KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL-RKTAARVE 658
K I A +S + D+ L ++T ++ L L + + L + A+
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPA---NKLSIETANDNDEKETDEADPAEMKLLLE 715
+ L ++ +K + + + T A K + +N ++ +E A KL
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL--- 1425
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E+ L++++++L D + ++ V L K + A + + A
Sbjct: 1426 --EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E R K E + + + L E E L + + + + L+ S+ D + +L++
Sbjct: 1484 EAREK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEK 1539
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+ +E + + KTQ E ++E TE+ KL+L N ++L+ DL + Q E
Sbjct: 1540 SKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEE 1596
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
+ ++ ++ E E +DE+ ++ + K E D LK +
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR 1655
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK 1015
QA +K D Q+ + + T + +K + LE ++ ++ + A + K
Sbjct: 1656 KLQAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 1016 EMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
+ A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 1712 Q--ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXX 1135
+ LSN+ T + E+ +L K S M +
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAAL 1826
Query: 1136 XXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Score = 74.9 bits (176), Expect = 3e-12
Identities = 146/775 (18%), Positives = 298/775 (38%), Gaps = 67/775 (8%)
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K + +K +E++ +L + S+ T EKN LQ ++ ++ A+ E + A K + LE
Sbjct: 872 KERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE- 929
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXX 1139
+ ++ + EE ++R Q L A+ K + + +
Sbjct: 930 ---ILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 1140 XXXXXQV-DNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ D +D NKL KE ++I D K + K + + +
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + V + EL K +L+ + L+A++ +LK
Sbjct: 1044 S-----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
K L++ +A D I Q +AL++ + + ++ R
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
+EL K +LE T +S+A + E+ A+ + ++ L+ +A
Sbjct: 1153 EELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E +L + ++ R + DK+ + + E A L G+L++L G + + K++
Sbjct: 1212 VE---ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKL 1264
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
E V++L+ + + EL K L+ E L +A+G+ + + K++++
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN----EAEGKAIKLAKDVASL 1320
Query: 1498 LGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELR 1557
+++ QE L E+ +K + + L+E ER N+ DQ + E+
Sbjct: 1321 SSQLQDTQELLQEETR----QKLNVSTKLRQLEE---------ER---NSLQDQLDEEME 1364
Query: 1558 AANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQ 1617
A + LE H D+ S ++ E+
Sbjct: 1365 AKQN----LERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEK 1418
Query: 1618 SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AA 1668
+ K E TK R + +++ + +L + VS +++ + Q+L A
Sbjct: 1419 AAAYDKLE--KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
++ AE + +K + + + + E + ++ + + ++L S+ K E
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQR 1783
L K + E ++ EM+++L E E+E L ++ A++ L ERD Q R
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQALKGQFERDLQAR 1590
Score = 68.5 bits (160), Expect = 2e-10
Identities = 107/539 (19%), Positives = 223/539 (41%), Gaps = 38/539 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 1490
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + E
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 444 KADQLEQEKA---------EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ + +++A E + K LE+ RE IK+L + A+ + L+
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 495 ELAEANSKFTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 1789
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
S++++ + + E + + S + A + + +VE++
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 1848
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKISSVTKTS-AGSNTTARRSLTTNSNKLAEE 777
L+R+++E + EA+ ++V L SK+ +TS S + R + N++ EE
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1964
Score = 62.9 bits (146), Expect = 1e-08
Identities = 170/935 (18%), Positives = 339/935 (36%), Gaps = 55/935 (5%)
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKEL---EMICQDEKSEKKVRFT 923
LQ+ + + +++ + TK+ Q ENELKE K +L + + Q++ + +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
EA + KQ Q K AQ+ + +
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 984 TT-KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-- 1040
KLQL+K+ + + + E +++ + + K + LE+ I ++ + L++ + +
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMD-DQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 1041 -FTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
T KN+ ++ I++L+ K E + + LE + S+ Q L ++ +
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 1100 QINKLSADLKNATS-LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNK 1158
Q+ K +L+ A + L ++ + K ++ K
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 1159 LLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANT 1218
L +E+ ++ D + E++++ K + Q +
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA---QVQEMRQK 1207
Query: 1219 HRRLSIELTSEKDELQARFIKTESKFITLEAEMRDL----------KADYENKITSLEST 1268
H + ELT + ++ + + TLE E DL K + E+K LE+
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 1269 IAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
+ E A R NDK + + VE V ++ + +L
Sbjct: 1268 VQELQSKCSDGERA-RAELNDKVHKLQNEVESVT--GMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
+ T+ + + + L +LE E L+ L +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG---AKRITELKQEYEETVKKLE 1445
KKL + + K ++ + E+ + A K L+QE ++ V L+
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 1446 HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
+ L + E+ K++ L E ++ E+++A+ E +KE + AL + L+
Sbjct: 1445 NQRQLV-SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR--EKE-TKALSLARALE 1500
Query: 1506 EKLGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
E L + T K EM++ ++S ++ + E+E+++ A Q E +
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSK-RALETQMEEMKTQLEEL 1558
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
D L+ D +ER + + + E+ +
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 1623 KAEITDTKTRYEGQMNTMR----DELKSLHNQVSRFRR---ERDNYKQMLEAAQKSMAEI 1675
+A K + EG + + +K + + R+ + ++++ LE A+ S EI
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 1676 ----KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLN--TEL 1729
K +K A+ + E+ + A +Q ++EL E LAS L+ L
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEE--LASSLSGRNAL 1734
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
EK E R+A+++ L E + S R R A
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Score = 57.2 bits (132), Expect = 6e-07
Identities = 121/610 (19%), Positives = 237/610 (38%), Gaps = 56/610 (9%)
Query: 1224 IELTSEKDELQAR---FIKTESKFITLEAEMRDLKADY----ENKITSLESTIAAKDVHI 1276
+++T +++E+QA+ KT+ + E E+++L+ + E K E A +++
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 1277 KQLEDALRQTTN-DKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+ E +R + +E +E + E ++ + + +LE+ EA
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+LE ++ + KLE+ E + +L T+L E +K
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 1394 MRIAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ +KNK ++ ++ L+ +LK E++ + + +LK++ E +A +
Sbjct: 1032 LT-----KLKNKHESMISELEVRLKKEEKSR----QELEKLKRKLEGDASDFHEQIADLQ 1082
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTES 1512
A+ EL + EEE ARL E Q L K++ G I LQE L +E
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1138
Query: 1513 AAWN---TEKTEMQNSIASLQERLCGG-GWEVERARLNARLDQRERELRAANDRRDVLEH 1568
AA N +K ++ + +L+ L + L A+ +Q L+ A D + H
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSH 1197
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE--KARKAEI 1626
E++ + +R + K E+
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 1627 TDTKTRYEGQMNTMRDELK-------SLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGD 1679
K + E Q+ ++ + L+++V + + E ++ ML A+ ++
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 1680 KSARIHRNSISSTDEEEYRNKVAL------LEQQVACLEDELCESRLLASKLNTELVSEK 1733
S +EE R K+ + LE++ L+D+L E + +K N E
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE--MEAKQNLE--RHI 1373
Query: 1734 SSAEVRLAEMQSRLNEYEEE-RLLSSGRAR----VAGLATRME---LAWHKERDEQQRLL 1785
S+ ++L++ + +L ++ L G+ R + L + E A+ K + RL
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 1786 QETSTLARDL 1795
QE L DL
Sbjct: 1434 QELDDLVVDL 1443
Score = 54.8 bits (126), Expect = 3e-06
Identities = 109/625 (17%), Positives = 249/625 (39%), Gaps = 26/625 (4%)
Query: 262 VDSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKS--DILLRRLANIDTANKYTTGRSSE 318
+ S +++ Q+ + E +Q++++ K + E+ S D L + ++ + + +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST----EAQTRQIEQLRAKL 374
+ ++K+ + + E L + KK ++I + + E + + E +++Q L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +L+ E +++ L + N ADE E + L
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL 1495
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR-LQ 493
+ L++ ++LE+ + ++ ++V D + + + ELE+ R+ E + ++
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHELEKS-KRALETQMEEMK 1552
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL-EREADL 552
+L E + + + +++ + E + R LQ L E E +L
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ R A K+ D ++ D+ + E+ +Q +M
Sbjct: 1613 EDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQRELED 1670
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--ESLLLQLK- 669
S + K E+ + + + +AA + A +E++ E L L
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
+ A + R+L + +E N E +D A + +L+ + AT R +
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNELATE-RSTAQ 1788
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
+ E ++ L++Q KEL SK+ + + +L +L EE+V+ E
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQAA 1847
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
K L +K++ + + ++ ++K K ++ + + + LKRQL+ E+E+ + A
Sbjct: 1848 TKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 850 KTQSLEADNEKLQTENKKLQLLKNA 874
+ L+ + ++ N+ + NA
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNA 1930
>AF001548-1|AAC31665.1| 1857|Homo sapiens Myosin heavy chain (MHY11)
(5'partial) protein.
Length = 1857
Score = 113 bits (273), Expect = 5e-24
Identities = 226/1115 (20%), Positives = 441/1115 (39%), Gaps = 94/1115 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
Q E ++ + D L+K ER +K +++ L ++ + T + + + Q EL
Sbjct: 735 QEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNLLQEQLQAETELYA 789
Query: 332 HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL-CEELMDENED 390
E++R Q++ EI E+E R E Q Q K +A + L EE ++E E
Sbjct: 790 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 849
Query: 391 MKKELR----DLXXXXXXMQDNF--REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++L+ ++D +DQ ++ S R+ LE+ I + L+ L + E K
Sbjct: 850 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD---LTTNLAEEEEK 906
Query: 445 ADQLEQEKAEHEKKL--LEIVGGPDGMQRENRIK---ELEQEVARSTEVALRLQRELAEA 499
A L + K +HE + LE+ + R+ K +LE + + E LQ ++AE
Sbjct: 907 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 966
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR----EQ 555
+ L ++++ + +E + DLQ+ L+ E R +Q
Sbjct: 967 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI-SDLQEDLDSERAARNKAEKQ 1025
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM-IHAASTPSSKE 614
R+ EE K T LD + E + ++ + H A ++
Sbjct: 1026 KRDLGEELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1084
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
K ++++ TE+ L F AN L K +E++N L +L+ +
Sbjct: 1085 KHAQ---AVEELTEQ---------LEQFKRAKAN-LDKNKQTLEKENADLAGELRVLG-- 1129
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
K KL + + E AE+ + + E + + E E
Sbjct: 1130 --QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1187
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L K V L+S++ T+ T + +++T +L EER L+D++DE +
Sbjct: 1188 AIKLAKDVASLSSQLQD-TQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQ 1245
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSL 854
ER L+ +LS ++KK + + +++A ++ +++++ + Q+ A L
Sbjct: 1246 NLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1303
Query: 855 EADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQD 913
E +LQ E L + L N + L S+ L+ +K QL E K +K + +
Sbjct: 1304 EKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEA 1361
Query: 914 EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFK 973
E EK+ + + + L++K+ L S KDD K+
Sbjct: 1362 EAREKETKALSLARALEEALEAKEELERTNKMLKAE--------MEDLVSSKDDVGKNVH 1413
Query: 974 PRIPKKPTDLTTKLQ-LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEKEI 1027
+ K L T+++ +K +E+LE E+ ++ + + L G+ +++
Sbjct: 1414 -ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1472
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC 1087
+E R +L + E+ E + + A KLEGD K LE + +
Sbjct: 1473 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-------LKDLELQADSAIKGR 1525
Query: 1088 KTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
+ ++++ +AQ+ +L++A + + + +
Sbjct: 1526 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1585
Query: 1148 NYTK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXX 1206
K D +K +L +E+ ++E++L + +
Sbjct: 1586 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1645
Query: 1207 XXXXQAVVLANTHRRLSIEL-TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSL 1265
QA L+N L+ E T++K+E + ++ ++K L +++ +++ ++K
Sbjct: 1646 KATQQAEQLSN---ELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKF--- 1697
Query: 1266 ESTIAAKDVHIKQLEDALRQTTNDKYDEATS------PVEMVEMRXXXXXXXXXXXXXQD 1319
+STIAA + I QLE+ + Q +K S ++ + ++ Q
Sbjct: 1698 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1757
Query: 1320 ELNNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
E NA++K LE+ E ES +L+ +L
Sbjct: 1758 EKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1792
Score = 97.9 bits (233), Expect = 3e-19
Identities = 187/935 (20%), Positives = 390/935 (41%), Gaps = 63/935 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCE-RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+++E ++ E +Q++ + + E +++K + +IL+ D NK S E L+
Sbjct: 839 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD----DQNNKL----SKERKLLE 890
Query: 324 QKVNELTTHNEDLRDEKKHLTQ---KIREIESELETRPSTEAQTRQ-IEQLRAKLLA-AE 378
+++++LTT+ + ++ K+LT+ K + SELE R E ++RQ +E+L+ KL A
Sbjct: 891 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 950
Query: 379 TLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR--RELEQTIKNCRV 433
E++ D + ++K +L ++ A + ++L+ RELE I + +
Sbjct: 951 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1010
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL---LEIVGGPDGMQRENRIKELEQEVA---RSTE 487
+ KA++ +++ E + L LE Q+E R K EQEV ++ +
Sbjct: 1011 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALD 1069
Query: 488 VALRL-QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQD 544
R + ++ E K + L + Q E K ++++L + +++ A L +L+
Sbjct: 1070 EETRSHEAQVQEMRQKHAQAVEELTE--QLEQFKRAKANLDKNKQTLEKENADLAGELRV 1127
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT---NSIQN 601
+ + ++ + + E + + + + D + +E E+VT N +
Sbjct: 1128 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEG 1186
Query: 602 KMIHAASTPSS--KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL-RKTAARVE 658
K I A +S + D+ L ++T ++ L L + + L + A+
Sbjct: 1187 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1246
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPA---NKLSIETANDNDEKETDEADPAEMKLLLE 715
+ L ++ +K + + + T A K + +N ++ +E A KL
Sbjct: 1247 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL--- 1303
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E+ L++++++L D + ++ V L K + A + + A
Sbjct: 1304 --EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1361
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E R K E + + + L E E L + + + + L+ S+ D + +L++
Sbjct: 1362 EAREK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEK 1417
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+ +E + + KTQ E ++E TE+ KL+L N ++L+ DL + Q E
Sbjct: 1418 SKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEE 1474
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
+ ++ ++ E E +DE+ ++ + K E D LK +
Sbjct: 1475 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR 1533
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK 1015
QA +K D Q+ + + T + +K + LE ++ ++ + A + K
Sbjct: 1534 KLQAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1589
Query: 1016 EMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
+ A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 1590 Q--ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1646
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXX 1135
+ LSN+ T + E+ +L K S M +
Sbjct: 1647 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAAL 1704
Query: 1136 XXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 1705 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1739
Score = 74.9 bits (176), Expect = 3e-12
Identities = 146/775 (18%), Positives = 298/775 (38%), Gaps = 67/775 (8%)
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K + +K +E++ +L + S+ T EKN LQ ++ ++ A+ E + A K + LE
Sbjct: 750 KERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE- 807
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXX 1139
+ ++ + EE ++R Q L A+ K + + +
Sbjct: 808 ---ILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 861
Query: 1140 XXXXXQV-DNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ D +D NKL KE ++I D K + K + + +
Sbjct: 862 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 921
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + V + EL K +L+ + L+A++ +LK
Sbjct: 922 S-----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 970
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
K L++ +A D I Q +AL++ + + ++ R
Sbjct: 971 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1030
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
+EL K +LE T +S+A + E+ A+ + ++ L+ +A
Sbjct: 1031 EELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1089
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E +L + ++ R + DK+ + + E A L G+L++L G + + K++
Sbjct: 1090 VE---ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKL 1142
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
E V++L+ + + EL K L+ E L +A+G+ + + K++++
Sbjct: 1143 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN----EAEGKAIKLAKDVASL 1198
Query: 1498 LGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELR 1557
+++ QE L E+ +K + + L+E ER N+ DQ + E+
Sbjct: 1199 SSQLQDTQELLQEETR----QKLNVSTKLRQLEE---------ER---NSLQDQLDEEME 1242
Query: 1558 AANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQ 1617
A + LE H D+ S ++ E+
Sbjct: 1243 AKQN----LERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEK 1296
Query: 1618 SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AA 1668
+ K E TK R + +++ + +L + VS +++ + Q+L A
Sbjct: 1297 AAAYDKLE--KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1354
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
++ AE + +K + + + + E + ++ + + ++L S+ K E
Sbjct: 1355 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1414
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQR 1783
L K + E ++ EM+++L E E+E L ++ A++ L ERD Q R
Sbjct: 1415 LEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQALKGQFERDLQAR 1468
Score = 68.5 bits (160), Expect = 2e-10
Identities = 107/539 (19%), Positives = 223/539 (41%), Gaps = 38/539 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 1311 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 1368
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 1369 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1428
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + E
Sbjct: 1429 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1488
Query: 444 KADQLEQEKA---------EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ + +++A E + K LE+ RE IK+L + A+ + L+
Sbjct: 1489 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1548
Query: 495 ELAEANSKFTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 1549 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1608
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 1609 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 1667
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
S++++ + + E + + S + A + + +VE++
Sbjct: 1668 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 1726
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 1727 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 1783
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKISSVTKTS-AGSNTTARRSLTTNSNKLAEE 777
L+R+++E + EA+ ++V L SK+ +TS S + R + N++ EE
Sbjct: 1784 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1842
Score = 62.9 bits (146), Expect = 1e-08
Identities = 170/935 (18%), Positives = 339/935 (36%), Gaps = 55/935 (5%)
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKEL---EMICQDEKSEKKVRFT 923
LQ+ + + +++ + TK+ Q ENELKE K +L + + Q++ + +
Sbjct: 730 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 789
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
EA + KQ Q K AQ+ + +
Sbjct: 790 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 849
Query: 984 TT-KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-- 1040
KLQL+K+ + + + E +++ + + K + LE+ I ++ + L++ + +
Sbjct: 850 ARQKLQLEKVTAEAKIKKLEDEILVMD-DQNNKLSKERKLLEERISDLTTNLAEEEEKAK 908
Query: 1041 -FTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
T KN+ ++ I++L+ K E + + LE + S+ Q L ++ +
Sbjct: 909 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 968
Query: 1100 QINKLSADLKNATS-LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNK 1158
Q+ K +L+ A + L ++ + K ++ K
Sbjct: 969 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1028
Query: 1159 LLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANT 1218
L +E+ ++ D + E++++ K + Q +
Sbjct: 1029 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA---QVQEMRQK 1085
Query: 1219 HRRLSIELTSEKDELQARFIKTESKFITLEAEMRDL----------KADYENKITSLEST 1268
H + ELT + ++ + + TLE E DL K + E+K LE+
Sbjct: 1086 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1145
Query: 1269 IAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
+ E A R NDK + + VE V ++ + +L
Sbjct: 1146 VQELQSKCSDGERA-RAELNDKVHKLQNEVESVT--GMLNEAEGKAIKLAKDVASLSSQL 1202
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
+ T+ + + + L +LE E L+ L +
Sbjct: 1203 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1262
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG---AKRITELKQEYEETVKKLE 1445
KKL + + K ++ + E+ + A K L+QE ++ V L+
Sbjct: 1263 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1322
Query: 1446 HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
+ L + E+ K++ L E ++ E+++A+ E +KE + AL + L+
Sbjct: 1323 NQRQLV-SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR--EKE-TKALSLARALE 1378
Query: 1506 EKLGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
E L + T K EM++ ++S ++ + E+E+++ A Q E +
Sbjct: 1379 EALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSK-RALETQMEEMKTQLEEL 1436
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
D L+ D +ER + + + E+ +
Sbjct: 1437 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1496
Query: 1623 KAEITDTKTRYEGQMNTMR----DELKSLHNQVSRFRR---ERDNYKQMLEAAQKSMAEI 1675
+A K + EG + + +K + + R+ + ++++ LE A+ S EI
Sbjct: 1497 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1556
Query: 1676 ----KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLN--TEL 1729
K +K A+ + E+ + A +Q ++EL E LAS L+ L
Sbjct: 1557 FATAKENEKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEE--LASSLSGRNAL 1612
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
EK E R+A+++ L E + S R R A
Sbjct: 1613 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1647
Score = 57.2 bits (132), Expect = 6e-07
Identities = 121/610 (19%), Positives = 237/610 (38%), Gaps = 56/610 (9%)
Query: 1224 IELTSEKDELQAR---FIKTESKFITLEAEMRDLKADY----ENKITSLESTIAAKDVHI 1276
+++T +++E+QA+ KT+ + E E+++L+ + E K E A +++
Sbjct: 730 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 789
Query: 1277 KQLEDALRQTTN-DKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+ E +R + +E +E + E ++ + + +LE+ EA
Sbjct: 790 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 849
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+LE ++ + KLE+ E + +L T+L E +K
Sbjct: 850 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 909
Query: 1394 MRIAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ +KNK ++ ++ L+ +LK E++ + + +LK++ E +A +
Sbjct: 910 LT-----KLKNKHESMISELEVRLKKEEKSR----QELEKLKRKLEGDASDFHEQIADLQ 960
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTES 1512
A+ EL + EEE ARL E Q L K++ G I LQE L +E
Sbjct: 961 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1016
Query: 1513 AAWN---TEKTEMQNSIASLQERLCGG-GWEVERARLNARLDQRERELRAANDRRDVLEH 1568
AA N +K ++ + +L+ L + L A+ +Q L+ A D + H
Sbjct: 1017 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSH 1075
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE--KARKAEI 1626
E++ + +R + K E+
Sbjct: 1076 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1135
Query: 1627 TDTKTRYEGQMNTMRDELK-------SLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGD 1679
K + E Q+ ++ + L+++V + + E ++ ML A+ ++
Sbjct: 1136 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1195
Query: 1680 KSARIHRNSISSTDEEEYRNKVAL------LEQQVACLEDELCESRLLASKLNTELVSEK 1733
S +EE R K+ + LE++ L+D+L E + +K N E
Sbjct: 1196 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE--MEAKQNLE--RHI 1251
Query: 1734 SSAEVRLAEMQSRLNEYEEE-RLLSSGRAR----VAGLATRME---LAWHKERDEQQRLL 1785
S+ ++L++ + +L ++ L G+ R + L + E A+ K + RL
Sbjct: 1252 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1311
Query: 1786 QETSTLARDL 1795
QE L DL
Sbjct: 1312 QELDDLVVDL 1321
Score = 54.8 bits (126), Expect = 3e-06
Identities = 109/625 (17%), Positives = 249/625 (39%), Gaps = 26/625 (4%)
Query: 262 VDSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKS--DILLRRLANIDTANKYTTGRSSE 318
+ S +++ Q+ + E +Q++++ K + E+ S D L + ++ + + +
Sbjct: 1198 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1257
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST----EAQTRQIEQLRAKL 374
+ ++K+ + + E L + KK ++I + + E + + E +++Q L
Sbjct: 1258 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1317
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +L+ E +++ L + N ADE E + L
Sbjct: 1318 VVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL 1373
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR-LQ 493
+ L++ ++LE+ + ++ ++V D + + + ELE+ R+ E + ++
Sbjct: 1374 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHELEKS-KRALETQMEEMK 1430
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL-EREADL 552
+L E + + + +++ + E + R LQ L E E +L
Sbjct: 1431 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1490
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ R A K+ D ++ D+ + E+ +Q +M
Sbjct: 1491 EDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQRELED 1548
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--ESLLLQLK- 669
S + K E+ + + + +AA + A +E++ E L L
Sbjct: 1549 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1608
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
+ A + R+L + +E N E +D A + +L+ + AT R +
Sbjct: 1609 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNELATE-RSTAQ 1666
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
+ E ++ L++Q KEL SK+ + + +L +L EE+V+ E
Sbjct: 1667 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQAA 1725
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
K L +K++ + + ++ ++K K ++ + + + LKRQL+ E+E+ + A
Sbjct: 1726 TKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQLKRQLEEAEEESQRINA 1783
Query: 850 KTQSLEADNEKLQTENKKLQLLKNA 874
+ L+ + ++ N+ + NA
Sbjct: 1784 NRRKLQRELDEATESNEAMGREVNA 1808
>AB020673-1|BAA74889.2| 1984|Homo sapiens KIAA0866 protein protein.
Length = 1984
Score = 113 bits (273), Expect = 5e-24
Identities = 226/1115 (20%), Positives = 441/1115 (39%), Gaps = 94/1115 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
Q E ++ + D L+K ER +K +++ L ++ + T + + + Q EL
Sbjct: 862 QEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNLLQEQLQAETELYA 916
Query: 332 HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL-CEELMDENED 390
E++R Q++ EI E+E R E Q Q K +A + L EE ++E E
Sbjct: 917 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 976
Query: 391 MKKELR----DLXXXXXXMQDNF--REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++L+ ++D +DQ ++ S R+ LE+ I + L+ L + E K
Sbjct: 977 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD---LTTNLAEEEEK 1033
Query: 445 ADQLEQEKAEHEKKL--LEIVGGPDGMQRENRIK---ELEQEVARSTEVALRLQRELAEA 499
A L + K +HE + LE+ + R+ K +LE + + E LQ ++AE
Sbjct: 1034 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1093
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR----EQ 555
+ L ++++ + +E + DLQ+ L+ E R +Q
Sbjct: 1094 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI-SDLQEDLDSERAARNKAEKQ 1152
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM-IHAASTPSSKE 614
R+ EE K T LD + E + ++ + H A ++
Sbjct: 1153 KRDLGEELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1211
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
K ++++ TE+ L F AN L K +E++N L +L+ +
Sbjct: 1212 KHAQ---AVEELTEQ---------LEQFKRAKAN-LDKNKQTLEKENADLAGELRVLG-- 1256
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
K KL + + E AE+ + + E + + E E
Sbjct: 1257 --QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1314
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L K V L+S++ T+ T + +++T +L EER L+D++DE +
Sbjct: 1315 AIKLAKDVASLSSQLQD-TQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQ 1372
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSL 854
ER L+ +LS ++KK + + +++A ++ +++++ + Q+ A L
Sbjct: 1373 NLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1430
Query: 855 EADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQD 913
E +LQ E L + L N + L S+ L+ +K QL E K +K + +
Sbjct: 1431 EKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEA 1488
Query: 914 EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFK 973
E EK+ + + + L++K+ L S KDD K+
Sbjct: 1489 EAREKETKALSLARALEEALEAKEELERTNKMLKAE--------MEDLVSSKDDVGKNVH 1540
Query: 974 PRIPKKPTDLTTKLQ-LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEKEI 1027
+ K L T+++ +K +E+LE E+ ++ + + L G+ +++
Sbjct: 1541 -ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1599
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC 1087
+E R +L + E+ E + + A KLEGD K LE + +
Sbjct: 1600 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-------LKDLELQADSAIKGR 1652
Query: 1088 KTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
+ ++++ +AQ+ +L++A + + + +
Sbjct: 1653 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1712
Query: 1148 NYTK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXX 1206
K D +K +L +E+ ++E++L + +
Sbjct: 1713 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1772
Query: 1207 XXXXQAVVLANTHRRLSIEL-TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSL 1265
QA L+N L+ E T++K+E + ++ ++K L +++ +++ ++K
Sbjct: 1773 KATQQAEQLSN---ELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKF--- 1824
Query: 1266 ESTIAAKDVHIKQLEDALRQTTNDKYDEATS------PVEMVEMRXXXXXXXXXXXXXQD 1319
+STIAA + I QLE+ + Q +K S ++ + ++ Q
Sbjct: 1825 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1884
Query: 1320 ELNNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
E NA++K LE+ E ES +L+ +L
Sbjct: 1885 EKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1919
Score = 97.9 bits (233), Expect = 3e-19
Identities = 187/935 (20%), Positives = 390/935 (41%), Gaps = 63/935 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCE-RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+++E ++ E +Q++ + + E +++K + +IL+ D NK S E L+
Sbjct: 966 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD----DQNNKL----SKERKLLE 1017
Query: 324 QKVNELTTHNEDLRDEKKHLTQ---KIREIESELETRPSTEAQTRQ-IEQLRAKLLA-AE 378
+++++LTT+ + ++ K+LT+ K + SELE R E ++RQ +E+L+ KL A
Sbjct: 1018 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1077
Query: 379 TLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR--RELEQTIKNCRV 433
E++ D + ++K +L ++ A + ++L+ RELE I + +
Sbjct: 1078 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1137
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL---LEIVGGPDGMQRENRIKELEQEVA---RSTE 487
+ KA++ +++ E + L LE Q+E R K EQEV ++ +
Sbjct: 1138 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALD 1196
Query: 488 VALRL-QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQD 544
R + ++ E K + L + Q E K ++++L + +++ A L +L+
Sbjct: 1197 EETRSHEAQVQEMRQKHAQAVEELTE--QLEQFKRAKANLDKNKQTLEKENADLAGELRV 1254
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT---NSIQN 601
+ + ++ + + E + + + + D + +E E+VT N +
Sbjct: 1255 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEG 1313
Query: 602 KMIHAASTPSS--KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL-RKTAARVE 658
K I A +S + D+ L ++T ++ L L + + L + A+
Sbjct: 1314 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1373
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPA---NKLSIETANDNDEKETDEADPAEMKLLLE 715
+ L ++ +K + + + T A K + +N ++ +E A KL
Sbjct: 1374 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL--- 1430
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E+ L++++++L D + ++ V L K + A + + A
Sbjct: 1431 --EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1488
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E R K E + + + L E E L + + + + L+ S+ D + +L++
Sbjct: 1489 EAREK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEK 1544
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+ +E + + KTQ E ++E TE+ KL+L N ++L+ DL + Q E
Sbjct: 1545 SKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEE 1601
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
+ ++ ++ E E +DE+ ++ + K E D LK +
Sbjct: 1602 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR 1660
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK 1015
QA +K D Q+ + + T + +K + LE ++ ++ + A + K
Sbjct: 1661 KLQAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1716
Query: 1016 EMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
+ A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 1717 Q--ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1773
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXX 1135
+ LSN+ T + E+ +L K S M +
Sbjct: 1774 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAAL 1831
Query: 1136 XXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 1832 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1866
Score = 74.9 bits (176), Expect = 3e-12
Identities = 146/775 (18%), Positives = 298/775 (38%), Gaps = 67/775 (8%)
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K + +K +E++ +L + S+ T EKN LQ ++ ++ A+ E + A K + LE
Sbjct: 877 KERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE- 934
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXX 1139
+ ++ + EE ++R Q L A+ K + + +
Sbjct: 935 ---ILHEMEARLEEEEDRGQQ---LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 988
Query: 1140 XXXXXQV-DNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ D +D NKL KE ++I D K + K + + +
Sbjct: 989 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1048
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + V + EL K +L+ + L+A++ +LK
Sbjct: 1049 S-----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1097
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
K L++ +A D I Q +AL++ + + ++ R
Sbjct: 1098 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1157
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
+EL K +LE T +S+A + E+ A+ + ++ L+ +A
Sbjct: 1158 EELEALKTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1216
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E +L + ++ R + DK+ + + E A L G+L++L G + + K++
Sbjct: 1217 VE---ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKL 1269
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
E V++L+ + + EL K L+ E L +A+G+ + + K++++
Sbjct: 1270 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN----EAEGKAIKLAKDVASL 1325
Query: 1498 LGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELR 1557
+++ QE L E+ +K + + L+E ER N+ DQ + E+
Sbjct: 1326 SSQLQDTQELLQEETR----QKLNVSTKLRQLEE---------ER---NSLQDQLDEEME 1369
Query: 1558 AANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQ 1617
A + LE H D+ S ++ E+
Sbjct: 1370 AKQN----LERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEK 1423
Query: 1618 SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AA 1668
+ K E TK R + +++ + +L + VS +++ + Q+L A
Sbjct: 1424 AAAYDKLE--KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1481
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
++ AE + +K + + + + E + ++ + + ++L S+ K E
Sbjct: 1482 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1541
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQR 1783
L K + E ++ EM+++L E E+E L ++ A++ L ERD Q R
Sbjct: 1542 LEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQALKGQFERDLQAR 1595
Score = 68.5 bits (160), Expect = 2e-10
Identities = 107/539 (19%), Positives = 223/539 (41%), Gaps = 38/539 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 1438 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 1495
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 1496 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1555
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + E
Sbjct: 1556 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1615
Query: 444 KADQLEQEKA---------EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ + +++A E + K LE+ RE IK+L + A+ + L+
Sbjct: 1616 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1675
Query: 495 ELAEANSKFTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 1676 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1735
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 1736 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 1794
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
S++++ + + E + + S + A + + +VE++
Sbjct: 1795 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 1853
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 1854 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 1910
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKISSVTKTS-AGSNTTARRSLTTNSNKLAEE 777
L+R+++E + EA+ ++V L SK+ +TS S + R + N++ EE
Sbjct: 1911 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1969
Score = 62.9 bits (146), Expect = 1e-08
Identities = 170/935 (18%), Positives = 339/935 (36%), Gaps = 55/935 (5%)
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKEL---EMICQDEKSEKKVRFT 923
LQ+ + + +++ + TK+ Q ENELKE K +L + + Q++ + +
Sbjct: 857 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 916
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
EA + KQ Q K AQ+ + +
Sbjct: 917 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 976
Query: 984 TT-KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-- 1040
KLQL+K+ + + + E +++ + + K + LE+ I ++ + L++ + +
Sbjct: 977 ARQKLQLEKVTAEAKIKKLEDEILVMD-DQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1035
Query: 1041 -FTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
T KN+ ++ I++L+ K E + + LE + S+ Q L ++ +
Sbjct: 1036 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1095
Query: 1100 QINKLSADLKNATS-LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNK 1158
Q+ K +L+ A + L ++ + K ++ K
Sbjct: 1096 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1155
Query: 1159 LLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANT 1218
L +E+ ++ D + E++++ K + Q +
Sbjct: 1156 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA---QVQEMRQK 1212
Query: 1219 HRRLSIELTSEKDELQARFIKTESKFITLEAEMRDL----------KADYENKITSLEST 1268
H + ELT + ++ + + TLE E DL K + E+K LE+
Sbjct: 1213 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1272
Query: 1269 IAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
+ E A R NDK + + VE V ++ + +L
Sbjct: 1273 VQELQSKCSDGERA-RAELNDKVHKLQNEVESVT--GMLNEAEGKAIKLAKDVASLSSQL 1329
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
+ T+ + + + L +LE E L+ L +
Sbjct: 1330 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1389
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG---AKRITELKQEYEETVKKLE 1445
KKL + + K ++ + E+ + A K L+QE ++ V L+
Sbjct: 1390 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1449
Query: 1446 HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
+ L + E+ K++ L E ++ E+++A+ E +KE + AL + L+
Sbjct: 1450 NQRQLV-SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR--EKE-TKALSLARALE 1505
Query: 1506 EKLGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
E L + T K EM++ ++S ++ + E+E+++ A Q E +
Sbjct: 1506 EALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSK-RALETQMEEMKTQLEEL 1563
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
D L+ D +ER + + + E+ +
Sbjct: 1564 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1623
Query: 1623 KAEITDTKTRYEGQMNTMR----DELKSLHNQVSRFRR---ERDNYKQMLEAAQKSMAEI 1675
+A K + EG + + +K + + R+ + ++++ LE A+ S EI
Sbjct: 1624 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1683
Query: 1676 ----KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLN--TEL 1729
K +K A+ + E+ + A +Q ++EL E LAS L+ L
Sbjct: 1684 FATAKENEKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEE--LASSLSGRNAL 1739
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
EK E R+A+++ L E + S R R A
Sbjct: 1740 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1774
Score = 57.2 bits (132), Expect = 6e-07
Identities = 121/610 (19%), Positives = 237/610 (38%), Gaps = 56/610 (9%)
Query: 1224 IELTSEKDELQAR---FIKTESKFITLEAEMRDLKADY----ENKITSLESTIAAKDVHI 1276
+++T +++E+QA+ KT+ + E E+++L+ + E K E A +++
Sbjct: 857 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 916
Query: 1277 KQLEDALRQTTN-DKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+ E +R + +E +E + E ++ + + +LE+ EA
Sbjct: 917 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 976
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+LE ++ + KLE+ E + +L T+L E +K
Sbjct: 977 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1036
Query: 1394 MRIAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ +KNK ++ ++ L+ +LK E++ + + +LK++ E +A +
Sbjct: 1037 LT-----KLKNKHESMISELEVRLKKEEKSR----QELEKLKRKLEGDASDFHEQIADLQ 1087
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTES 1512
A+ EL + EEE ARL E Q L K++ G I LQE L +E
Sbjct: 1088 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSER 1143
Query: 1513 AAWN---TEKTEMQNSIASLQERLCGG-GWEVERARLNARLDQRERELRAANDRRDVLEH 1568
AA N +K ++ + +L+ L + L A+ +Q L+ A D + H
Sbjct: 1144 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD-EETRSH 1202
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE--KARKAEI 1626
E++ + +R + K E+
Sbjct: 1203 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1262
Query: 1627 TDTKTRYEGQMNTMRDELK-------SLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGD 1679
K + E Q+ ++ + L+++V + + E ++ ML A+ ++
Sbjct: 1263 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1322
Query: 1680 KSARIHRNSISSTDEEEYRNKVAL------LEQQVACLEDELCESRLLASKLNTELVSEK 1733
S +EE R K+ + LE++ L+D+L E + +K N E
Sbjct: 1323 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE--MEAKQNLE--RHI 1378
Query: 1734 SSAEVRLAEMQSRLNEYEEE-RLLSSGRAR----VAGLATRME---LAWHKERDEQQRLL 1785
S+ ++L++ + +L ++ L G+ R + L + E A+ K + RL
Sbjct: 1379 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1438
Query: 1786 QETSTLARDL 1795
QE L DL
Sbjct: 1439 QELDDLVVDL 1448
Score = 54.8 bits (126), Expect = 3e-06
Identities = 109/625 (17%), Positives = 249/625 (39%), Gaps = 26/625 (4%)
Query: 262 VDSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKS--DILLRRLANIDTANKYTTGRSSE 318
+ S +++ Q+ + E +Q++++ K + E+ S D L + ++ + + +
Sbjct: 1325 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1384
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST----EAQTRQIEQLRAKL 374
+ ++K+ + + E L + KK ++I + + E + + E +++Q L
Sbjct: 1385 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1444
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +L+ E +++ L + N ADE E + L
Sbjct: 1445 VVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL 1500
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR-LQ 493
+ L++ ++LE+ + ++ ++V D + + + ELE+ R+ E + ++
Sbjct: 1501 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHELEKS-KRALETQMEEMK 1557
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL-EREADL 552
+L E + + + +++ + E + R LQ L E E +L
Sbjct: 1558 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1617
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ R A K+ D ++ D+ + E+ +Q +M
Sbjct: 1618 EDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQRELED 1675
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--ESLLLQLK- 669
S + K E+ + + + +AA + A +E++ E L L
Sbjct: 1676 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1735
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
+ A + R+L + +E N E +D A + +L+ + AT R +
Sbjct: 1736 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNELATE-RSTAQ 1793
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
+ E ++ L++Q KEL SK+ + + +L +L EE+V+ E
Sbjct: 1794 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQAA 1852
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
K L +K++ + + ++ ++K K ++ + + + LKRQL+ E+E+ + A
Sbjct: 1853 TKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQLKRQLEEAEEESQRINA 1910
Query: 850 KTQSLEADNEKLQTENKKLQLLKNA 874
+ L+ + ++ N+ + NA
Sbjct: 1911 NRRKLQRELDEATESNEAMGREVNA 1935
>M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein.
Length = 1976
Score = 113 bits (271), Expect = 8e-24
Identities = 183/897 (20%), Positives = 378/897 (42%), Gaps = 77/897 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR---RLANIDTANKYTTGRSSE 318
+D + QDQI L+ ++D L+ + + E+E L R + + A K ++
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ +LQ+ +K+ L++++ +++ELE T A +++ R + +A
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA-- 1177
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
L + L +E ++ + +++D+ + E Q ++ + LE KN + L
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSE-QLEQAKRFKANLE---KNKQGLETDN 1233
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
K+ + L+Q KAE E K ++ + +++EL +V+ RL+ ELAE
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKL---------DAQVQELHAKVSEGD----RLRVELAE 1280
Query: 499 ANSKFTG--SNPS-LMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
SK N S L++ + + +K ++ + + +D +L LQ+ ++ +L +
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL---LQEETRQKLNLSSR 1337
Query: 556 LRNAEEETANCKQVNPP-----TFLDKQVM--------TDNIVTCDIHESETVTNSIQNK 602
+R EEE + ++ L+KQV+ T V D+ E++ + +
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSI-FNHMAANNLRKTAARVEE-- 659
+ A + E+ ++KT Q D + + A+NL K + ++
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457
Query: 660 -DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
+ +S+ + + +A + A L+ + KE E +++ +E
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEE 777
+ + V ELE+ K AL++QV+E+ +++ + + A + R + + K E
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R DE +E +K+L+ K+ L AEL +K+ + S+ D + DL+ Q+
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQ--VRELEAELEDERKQRALAVASKKKMEIDLK--DLEAQI 1633
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKN---AKSLRSDKALDLNTKKTTQLE 894
+ + + + + L+A + Q E ++ + ++ A+S S+K L + QL+
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
E LA + + E+ E T + ++ L K+
Sbjct: 1694 EE----LASSERARRHAEQERDELADEITNSASGKSALLDEKR----RLEARIAQLEEEL 1745
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q+ ++ L D +K+ ++ +L + + ++ ++ +K A L
Sbjct: 1746 EEEQSNMELLNDRFRKT-TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK-AKLQE 1803
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNE------KNRL--QTEIAKLKDVNAKLEGDK 1066
E K+K + I + +K+ + + + E N+L +TE KLK++ ++E D+
Sbjct: 1804 LEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE-KKLKEIFMQVE-DE 1861
Query: 1067 DVFANKYK-ALENENS---NLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
A++YK +E N+ L Q + EE A KL +L +AT +S
Sbjct: 1862 RRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918
Score = 93.5 bits (222), Expect = 7e-18
Identities = 193/1095 (17%), Positives = 427/1095 (38%), Gaps = 75/1095 (6%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKK---QVKELTSKISSVT--KTSAGSNTTA 763
++K LL++ QE L+ K EEL + KE K +++E+ K + K A
Sbjct: 840 KVKPLLQVTRQEEE-LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL 823
L + ++ R+ + E++E+ L + + E + L +KK + I+
Sbjct: 899 ETELFAEAEEM-RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKAL 883
+++ K QL+ + E AK + +E + L+ +N K +K K L D+
Sbjct: 958 QLDEEEGARQKLQLEKVTAE-----AKIKKMEEEILLLEDQNSK--FIKE-KKLMEDRIA 1009
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ +++ E E + LAKI+ + + + E++++ E T++E + K K
Sbjct: 1010 ECSSQLAE--EEEKAKNLAKIRNKQEVMISD-LEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
LK ++ + + + + K K+V +L+ +I E+
Sbjct: 1067 LQDQIAELQAQID---ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 1004 YVVMKNAGLS-GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
++ S K K L +E++ ++++L ++ + T + L+T K + A+L
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTEL-EDTLDTTAAQQELRT---KREQEVAEL 1179
Query: 1063 EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL-KNATSLQTTMSDC 1121
K + K E + ++ + T EE+ + Q + A+L KN L+T +
Sbjct: 1180 ---KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
QV + ++L E+ +K K+ +
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 1182 XXCK----RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQ 1234
+ + K ++ + ++ Q + L++ R+L E L +++E +
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 1235 ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK---Y 1291
E + + L++++ D K ++ + ++ES AK +K E AL Q +K Y
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE-ALSQRLEEKALAY 1415
Query: 1292 DEATSPVEMVEMR-XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
D+ ++ L + K ++ AE + A+ + D A
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAE-ERDRA 1474
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELA 1410
+ E + +AKE + + Q+++ + D + KD K+
Sbjct: 1475 EAEAREKETKALSLARALEEAL---EAKE-EFERQNKQLRADMEDLMSSKDDVGKNVH-- 1528
Query: 1411 TLKGKLKILEQNSGAGAKRITELKQEY---EETVKKLEHSLALEKAEYEELTGKYELLEE 1467
L+ + LEQ ++ EL+ E E+ +LE ++ KA++E + +E
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQTRDE 1585
Query: 1468 EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQN 1524
++ K L + + + EL +K+ + A+ K ++ + L + A N + E+
Sbjct: 1586 QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645
Query: 1525 SIASLQERLCGGGWEVERARLNAR---LDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
+ LQ ++ E+E AR + +E E + + ++L+ +
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA--- 1702
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
R ++ +R ++ +AR A++ + + M +
Sbjct: 1703 ------RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756
Query: 1642 DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
D + QV E + + + + +++ +K + + + +++ +
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 1702 ALLEQQVACLEDEL---CESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
+ LE ++ LE++L + R A+KL + +++ + + ++Y+E+ +
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ--MEK 1874
Query: 1759 GRARVAGLATRMELA 1773
AR+ L ++E A
Sbjct: 1875 ANARMKQLKRQLEEA 1889
Score = 82.2 bits (194), Expect = 2e-14
Identities = 178/932 (19%), Positives = 358/932 (38%), Gaps = 68/932 (7%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK 711
K A++ E ++ L++ K + KL ET + D+ +A E+K
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Query: 712 LLLELNEQEAT-VLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L L E+E L R +E ALK V+EL ++I+ + + S +R
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKV-VRELQAQIAEL-QEDFESEKASRNKAEKQ 1140
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
L+EE ++ L+ E+++ ++ + E++ +K + K+ D +
Sbjct: 1141 KRDLSEE-LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199
Query: 831 ------VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
+L QL+ ++ + L Q LE DN++L E K LQ +K A+S K LD
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK-AESEHKRKKLD 1258
Query: 885 -----LNTK--KTTQLENELKEALAKIK-ELEMICQ--DEKSEKKVRFTEATKKETDTLK 934
L+ K + +L EL E +K++ EL+ + +E +K ++F + L+
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE 994
Q + SL++ ++ + R + L + QL +
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1378
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKND---SEFTNEKNRLQTE 1051
++ ++G + + + AK KL K+ + + +L + + KNRLQ E
Sbjct: 1379 KVDDDLGTIESLEE----------AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
L D+ L+ + V +N K + + L+ + + R+ + A
Sbjct: 1429 ---LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485
Query: 1112 TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD----NYTKIDQDKNKLLKEVGDKT 1167
SL + + + D N ++++ K L ++V +
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 1168 KKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV-VLANTHRRLSIEL 1226
++ + R+E + K + + +L R L EL
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605
Query: 1227 TSEKDELQARFIKTESKFITLEAEMRDLKADYE--NK-----ITSLESTIAAKDVHIKQL 1279
+DE + R + SK +E +++DL+A E NK I L A + ++L
Sbjct: 1606 ---EDERKQRALAVASK-KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661
Query: 1280 EDA-------LRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE 1332
E+A Q+ + + E+++++ + E + ++ +
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 1333 AESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER---K 1389
+ SA E +L++ +A+LE + L+ +L +ER +
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781
Query: 1390 KLDRMRIAHDKDVKNKDAELATLKGKLKI-LEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
K D R ++ K A+L L+G +K + A +I +L+++ E+ K+ +
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAAN 1841
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE---IKTLQ 1505
L + ++L + +E+E + + E+A + ++++L A E +
Sbjct: 1842 KLVRRTEKKLKEIFMQVEDERRHAD-QYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGG 1537
KL E + +++L+ RL GG
Sbjct: 1901 RKLQRELDDATEANEGLSREVSTLKNRLRRGG 1932
Score = 80.6 bits (190), Expect = 5e-14
Identities = 206/1092 (18%), Positives = 429/1092 (39%), Gaps = 89/1092 (8%)
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+L++ ++ EL +E+L K+ T+ +E ELE Q + + + A+ L AE
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTK----VEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 379 TLCEELMDENEDMKKEL----RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
T EL E E+M+ L ++L ++ E++ + L+ E ++ + + L
Sbjct: 900 T---ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE-ERNQILQNEKKKMQAHIQDL 955
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENR--IKELEQEVARSTEVALRL 492
+L + E +L+ EK E K+ ++ ++ +N IKE + R E + +L
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
E +A + N + + E ++ + TR ++ +L + D ++ A+L
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEE-RLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL 1074
Query: 553 REQLRNAEEETANCKQVNPPTFL--DKQVMTDNIVTCDIHESETVTNSIQN--KMIHAAS 608
+ Q+ + + A ++ D + + N + E + +Q + A+
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134
Query: 609 TPSSKEKSD-SPPLSIDKTTEETQFHFDLPY--LSIFNHMAANNLRKTAARVEEDNESLL 665
+ K+K D S L KT E L L+K +++E+ +
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPA-EMKLLLEL---NEQEA 721
+++ A A + + ETD + A E+K+L ++ +E +
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
L +V+EL + EL K S + + + +T K A++
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKL-QNELDNVSTLLEEAEKKGIKFAKDAAS- 1312
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE 841
LE ++ + ++ L E+ R L + + +++ +L + + + ++N L++Q+ ++
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN--LEKQVLALQ 1370
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLR---SDKAL--DLNTKKTTQLENE 896
+ + + K E L+ KK LLK+A++L +KAL D K +L+ E
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKK--LLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428
Query: 897 LKEALAKIKELEMICQD-EKSEKK------------VRFTEATKKETDTLKSKQXXXXXX 943
L + + + + EK +KK R+ E + + K+
Sbjct: 1429 LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1488
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQ--KSFKPRIPKKPTDL-TTKLQLKKMVEDLECEI 1000
+ K L+ D + S K + K +L +K L++ VE++ ++
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL 1548
Query: 1001 GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKN---DSEFTNEKNRLQTEIAKLKD 1057
E+ L E AK +LE + ++++ ++ E EK RL I ++++
Sbjct: 1549 EEL-----EDELQATE-DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL--IKQVRE 1600
Query: 1058 VNAKLEGDKD----VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN-AT 1112
+ A+LE ++ A+K K +E + +L Q + + Q+ KL A +K+
Sbjct: 1601 LEAELEDERKQRALAVASK-KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD 1172
L+ + + ++ + +E + +I +
Sbjct: 1660 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+R+E +++ ++ + + L+ EL +E+
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779
Query: 1233 LQARFIKTESKFITLEAEMRDLKA---DYENKITS-LESTIAAKDVHIKQLEDALRQ--- 1285
Q K+++ LE + ++LKA + E + S ++TI+A + I QLE+ L Q
Sbjct: 1780 AQ----KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1835
Query: 1286 ---TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK-----LEKTEAESSA 1337
N ++ + M+ Q E NA++K LE+ E E++
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1895
Query: 1338 AKLEMAQLKSDL 1349
A +L+ +L
Sbjct: 1896 ANASRRKLQREL 1907
Score = 77.8 bits (183), Expect = 4e-13
Identities = 201/1089 (18%), Positives = 407/1089 (37%), Gaps = 89/1089 (8%)
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
++ E +KV G E+ + R Q LE + L EQL+ E A +++
Sbjct: 854 LQAKDEELLKVKEKQTKVEGELEE---MERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 571 PPTFLDKQVMTDNIVTCD--IHESETVTNSIQN---KM---IHAASTPSSKEKSDSPPLS 622
KQ + + + + + E E +QN KM I +E+ L
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 623 IDKTTEETQF---HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRK 679
++K T E + ++ L N + R+ E + L + +K A+ R
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 680 LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALK 739
++ +E +EK E + A+ KL + E T L+ ++ EL+ + LK
Sbjct: 1031 KQEVMISD---LEERLKKEEKTRQELEKAKRKL-----DGETTDLQDQIAELQAQIDELK 1082
Query: 740 KQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERD 799
Q+ + ++ + G + T ++ + + ++ L+++ + + + E+
Sbjct: 1083 LQLAKKEEELQGAL--ARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 800 CERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE 859
L EL KT ++ + QQ + KR+ +V E + + L +T++ EA +
Sbjct: 1141 KRDLSEELEAL----KTELEDTLDTTAAQQELRTKREQEVAELKKA-LEEETKNHEAQIQ 1195
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMI-CQDEKSE 917
++ + L + ++ L K N +K Q LE + KE ++K L+ + + E
Sbjct: 1196 DMR-QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 918 KK----VRFTEATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
KK V+ A E D L+ + + + +K KD A
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 972 FKPRIPKKPTDLTT--KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
+ + ++ T KL L + LE E + + +E A+ LEK++
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE------EEEEARKNLEKQVLA 1368
Query: 1030 IRSKLSKNDSEFTNEKNRLQT-EIAK---LKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
++S+L+ + ++ +++ E AK LKD A L + A Y LE + L
Sbjct: 1369 LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA-LSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 1086 QCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ 1145
+ LT ++ ++ + L K L
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487
Query: 1146 VDN-YTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
+ + + K + ++ + D +EK + +V
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDE----LQARFIKTESKFITLEAEMRDLKADYEN 1260
+ + RL + + + K + LQ R + E K L ++R+L+A+ E+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 1261 KITSLESTIAAK---DVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXX 1317
+ +A+K ++ +K LE + + N DE + ++ +
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQI-EAANKARDEVIKQLRKLQAQMKDY--------- 1657
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
Q EL A+ ++ A+S ++ ++ L++++ +L+ + A
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER---DELA 1714
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E+ + LD R +A +A L+ +L+ + N R + +
Sbjct: 1715 DEITNSASGKSALLDEKR--------RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ- 1765
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
V L LA E++ ++ + LE ++ KA+L + + + L
Sbjct: 1766 ---VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK 1822
Query: 1498 LGEIKTLQEKLGTESAAWN-----TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+G+++ E+ E AA N TEK + + ER ++ + + NAR+ Q
Sbjct: 1823 IGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL 1882
Query: 1553 ERELRAAND 1561
+R+L A +
Sbjct: 1883 KRQLEEAEE 1891
Score = 57.6 bits (133), Expect = 4e-07
Identities = 92/479 (19%), Positives = 189/479 (39%), Gaps = 32/479 (6%)
Query: 1329 EKTEAESSAAKLEMAQLKSDL-AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
E+ A +A K E+ ++ DL +++E ++ ++ ++LD + +
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-EGA 965
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
R+KL ++ + +K + E+ L+ + + RI E + E +K ++
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
+ + ++ E L++E T+ L K + GE +Q +++ +I L+ +
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEK-TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERAR-LNARLDQRERELRAANDRRDVL 1566
L + + E+Q ++A + ++ R L A++ + + + + R+
Sbjct: 1085 LAKK-------EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 1567 EHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEI 1626
E D + Q+ +E+ K +A+I
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA---LEEETKNHEAQI 1194
Query: 1627 TDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMA-EIK--NGDKSAR 1683
D + R+ + + ++L+ Q RF+ + KQ LE K +A E+K K+
Sbjct: 1195 QDMRQRHATALEELSEQLE----QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 1684 IHRNSISSTDEEEYRNKVA-------LLEQQVACLEDELCE-SRLL--ASKLNTELVSEK 1733
H+ +E KV+ L ++ + L++EL S LL A K + +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 1734 SSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLA 1792
+S E +L + Q L E ++L S R R + L +E +E+ R E LA
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLE-EEKNSLQEQQEEEEEARKNLEKQVLA 1368
Score = 39.9 bits (89), Expect = 0.091
Identities = 41/169 (24%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Query: 1619 EKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNG 1678
EK AE +T + MR L + ++ + ++ +E ++ ++N
Sbjct: 888 EKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES---RVEEEEERNQILQNE 944
Query: 1679 DKSARIHRNSISST-DEEE-YRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA 1736
K + H + DEEE R K+ L + ++ E LL N++ + EK
Sbjct: 945 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004
Query: 1737 EVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKERDEQQRL 1784
E R+AE S+L E EE+ + L+ R + + + +E KE +Q L
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
>BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 113 bits (271), Expect = 8e-24
Identities = 183/897 (20%), Positives = 378/897 (42%), Gaps = 77/897 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR---RLANIDTANKYTTGRSSE 318
+D + QDQI L+ ++D L+ + + E+E L R + + A K ++
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ +LQ+ +K+ L++++ +++ELE T A +++ R + +A
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA-- 1177
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
L + L +E ++ + +++D+ + E Q ++ + LE KN + L
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSE-QLEQAKRFKANLE---KNKQGLETDN 1233
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
K+ + L+Q KAE E K ++ + +++EL +V+ RL+ ELAE
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKL---------DAQVQELHAKVSEGD----RLRVELAE 1280
Query: 499 ANSKFTG--SNPS-LMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
SK N S L++ + + +K ++ + + +D +L LQ+ ++ +L +
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL---LQEETRQKLNLSSR 1337
Query: 556 LRNAEEETANCKQVNPP-----TFLDKQVM--------TDNIVTCDIHESETVTNSIQNK 602
+R EEE + ++ L+KQV+ T V D+ E++ + +
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSI-FNHMAANNLRKTAARVEE-- 659
+ A + E+ ++KT Q D + + A+NL K + ++
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457
Query: 660 -DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
+ +S+ + + +A + A L+ + KE E +++ +E
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEE 777
+ + V ELE+ K AL++QV+E+ +++ + + A + R + + K E
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R DE +E +K+L+ K+ L AEL +K+ + S+ D + DL+ Q+
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQ--VRELEAELEDERKQRALAVASKKKMEIDLK--DLEAQI 1633
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKN---AKSLRSDKALDLNTKKTTQLE 894
+ + + + + L+A + Q E ++ + ++ A+S S+K L + QL+
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
E LA + + E+ E T + ++ L K+
Sbjct: 1694 EE----LASSERARRHAEQERDELADEITNSASGKSALLDEKR----RLEARIAQLEEEL 1745
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q+ ++ L D +K+ ++ +L + + ++ ++ +K A L
Sbjct: 1746 EEEQSNMELLNDRFRKT-TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK-AKLQE 1803
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNE------KNRL--QTEIAKLKDVNAKLEGDK 1066
E K+K + I + +K+ + + + E N+L +TE KLK++ ++E D+
Sbjct: 1804 LEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE-KKLKEIFMQVE-DE 1861
Query: 1067 DVFANKYK-ALENENS---NLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
A++YK +E N+ L Q + EE A KL +L +AT +S
Sbjct: 1862 RRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918
Score = 93.5 bits (222), Expect = 7e-18
Identities = 193/1095 (17%), Positives = 427/1095 (38%), Gaps = 75/1095 (6%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKK---QVKELTSKISSVT--KTSAGSNTTA 763
++K LL++ QE L+ K EEL + KE K +++E+ K + K A
Sbjct: 840 KVKPLLQVTRQEEE-LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL 823
L + ++ R+ + E++E+ L + + E + L +KK + I+
Sbjct: 899 ETELFAEAEEM-RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKAL 883
+++ K QL+ + E AK + +E + L+ +N K +K K L D+
Sbjct: 958 QLDEEEGARQKLQLEKVTAE-----AKIKKMEEEILLLEDQNSK--FIKE-KKLMEDRIA 1009
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ +++ E E + LAKI+ + + + E++++ E T++E + K K
Sbjct: 1010 ECSSQLAE--EEEKAKNLAKIRNKQEVMISD-LEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
LK ++ + + + + K K+V +L+ +I E+
Sbjct: 1067 LQDQIAELQAQID---ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 1004 YVVMKNAGLS-GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
++ S K K L +E++ ++++L ++ + T + L+T K + A+L
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTEL-EDTLDTTAAQQELRT---KREQEVAEL 1179
Query: 1063 EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL-KNATSLQTTMSDC 1121
K + K E + ++ + T EE+ + Q + A+L KN L+T +
Sbjct: 1180 ---KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
QV + ++L E+ +K K+ +
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 1182 XXCK----RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQ 1234
+ + K ++ + ++ Q + L++ R+L E L +++E +
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 1235 ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK---Y 1291
E + + L++++ D K ++ + ++ES AK +K E AL Q +K Y
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE-ALSQRLEEKALAY 1415
Query: 1292 DEATSPVEMVEMR-XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
D+ ++ L + K ++ AE + A+ + D A
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAE-ERDRA 1474
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELA 1410
+ E + +AKE + + Q+++ + D + KD K+
Sbjct: 1475 EAEAREKETKALSLARALEEAL---EAKE-EFERQNKQLRADMEDLMSSKDDVGKNVH-- 1528
Query: 1411 TLKGKLKILEQNSGAGAKRITELKQEY---EETVKKLEHSLALEKAEYEELTGKYELLEE 1467
L+ + LEQ ++ EL+ E E+ +LE ++ KA++E + +E
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQTRDE 1585
Query: 1468 EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQN 1524
++ K L + + + EL +K+ + A+ K ++ + L + A N + E+
Sbjct: 1586 QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645
Query: 1525 SIASLQERLCGGGWEVERARLNAR---LDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
+ LQ ++ E+E AR + +E E + + ++L+ +
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA--- 1702
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
R ++ +R ++ +AR A++ + + M +
Sbjct: 1703 ------RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756
Query: 1642 DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
D + QV E + + + + +++ +K + + + +++ +
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 1702 ALLEQQVACLEDEL---CESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
+ LE ++ LE++L + R A+KL + +++ + + ++Y+E+ +
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ--MEK 1874
Query: 1759 GRARVAGLATRMELA 1773
AR+ L ++E A
Sbjct: 1875 ANARMKQLKRQLEEA 1889
Score = 82.2 bits (194), Expect = 2e-14
Identities = 178/932 (19%), Positives = 358/932 (38%), Gaps = 68/932 (7%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK 711
K A++ E ++ L++ K + KL ET + D+ +A E+K
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Query: 712 LLLELNEQEAT-VLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L L E+E L R +E ALK V+EL ++I+ + + S +R
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKV-VRELQAQIAEL-QEDFESEKASRNKAEKQ 1140
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
L+EE ++ L+ E+++ ++ + E++ +K + K+ D +
Sbjct: 1141 KRDLSEE-LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199
Query: 831 ------VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
+L QL+ ++ + L Q LE DN++L E K LQ +K A+S K LD
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK-AESEHKRKKLD 1258
Query: 885 -----LNTK--KTTQLENELKEALAKIK-ELEMICQ--DEKSEKKVRFTEATKKETDTLK 934
L+ K + +L EL E +K++ EL+ + +E +K ++F + L+
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE 994
Q + SL++ ++ + R + L + QL +
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1378
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKND---SEFTNEKNRLQTE 1051
++ ++G + + + AK KL K+ + + +L + + KNRLQ E
Sbjct: 1379 KVDDDLGTIESLEE----------AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
L D+ L+ + V +N K + + L+ + + R+ + A
Sbjct: 1429 ---LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485
Query: 1112 TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD----NYTKIDQDKNKLLKEVGDKT 1167
SL + + + D N ++++ K L ++V +
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 1168 KKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV-VLANTHRRLSIEL 1226
++ + R+E + K + + +L R L EL
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605
Query: 1227 TSEKDELQARFIKTESKFITLEAEMRDLKADYE--NK-----ITSLESTIAAKDVHIKQL 1279
+DE + R + SK +E +++DL+A E NK I L A + ++L
Sbjct: 1606 ---EDERKQRALAVASK-KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661
Query: 1280 EDA-------LRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE 1332
E+A Q+ + + E+++++ + E + ++ +
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 1333 AESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER---K 1389
+ SA E +L++ +A+LE + L+ +L +ER +
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781
Query: 1390 KLDRMRIAHDKDVKNKDAELATLKGKLKI-LEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
K D R ++ K A+L L+G +K + A +I +L+++ E+ K+ +
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAAN 1841
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE---IKTLQ 1505
L + ++L + +E+E + + E+A + ++++L A E +
Sbjct: 1842 KLVRRTEKKLKEIFMQVEDERRHAD-QYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGG 1537
KL E + +++L+ RL GG
Sbjct: 1901 RKLQRELDDATEANEGLSREVSTLKNRLRRGG 1932
Score = 80.6 bits (190), Expect = 5e-14
Identities = 206/1092 (18%), Positives = 429/1092 (39%), Gaps = 89/1092 (8%)
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+L++ ++ EL +E+L K+ T+ +E ELE Q + + + A+ L AE
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTK----VEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 379 TLCEELMDENEDMKKEL----RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
T EL E E+M+ L ++L ++ E++ + L+ E ++ + + L
Sbjct: 900 T---ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE-ERNQILQNEKKKMQAHIQDL 955
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENR--IKELEQEVARSTEVALRL 492
+L + E +L+ EK E K+ ++ ++ +N IKE + R E + +L
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
E +A + N + + E ++ + TR ++ +L + D ++ A+L
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEE-RLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL 1074
Query: 553 REQLRNAEEETANCKQVNPPTFL--DKQVMTDNIVTCDIHESETVTNSIQN--KMIHAAS 608
+ Q+ + + A ++ D + + N + E + +Q + A+
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134
Query: 609 TPSSKEKSD-SPPLSIDKTTEETQFHFDLPY--LSIFNHMAANNLRKTAARVEEDNESLL 665
+ K+K D S L KT E L L+K +++E+ +
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPA-EMKLLLEL---NEQEA 721
+++ A A + + ETD + A E+K+L ++ +E +
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
L +V+EL + EL K S + + + +T K A++
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKL-QNELDNVSTLLEEAEKKGIKFAKDAAS- 1312
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE 841
LE ++ + ++ L E+ R L + + +++ +L + + + ++N L++Q+ ++
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN--LEKQVLALQ 1370
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLR---SDKAL--DLNTKKTTQLENE 896
+ + + K E L+ KK LLK+A++L +KAL D K +L+ E
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKK--LLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428
Query: 897 LKEALAKIKELEMICQD-EKSEKK------------VRFTEATKKETDTLKSKQXXXXXX 943
L + + + + EK +KK R+ E + + K+
Sbjct: 1429 LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1488
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQ--KSFKPRIPKKPTDL-TTKLQLKKMVEDLECEI 1000
+ K L+ D + S K + K +L +K L++ VE++ ++
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL 1548
Query: 1001 GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKN---DSEFTNEKNRLQTEIAKLKD 1057
E+ L E AK +LE + ++++ ++ E EK RL I ++++
Sbjct: 1549 EEL-----EDELQATE-DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL--IKQVRE 1600
Query: 1058 VNAKLEGDKD----VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN-AT 1112
+ A+LE ++ A+K K +E + +L Q + + Q+ KL A +K+
Sbjct: 1601 LEAELEDERKQRALAVASK-KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD 1172
L+ + + ++ + +E + +I +
Sbjct: 1660 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+R+E +++ ++ + + L+ EL +E+
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779
Query: 1233 LQARFIKTESKFITLEAEMRDLKA---DYENKITS-LESTIAAKDVHIKQLEDALRQ--- 1285
Q K+++ LE + ++LKA + E + S ++TI+A + I QLE+ L Q
Sbjct: 1780 AQ----KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1835
Query: 1286 ---TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK-----LEKTEAESSA 1337
N ++ + M+ Q E NA++K LE+ E E++
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1895
Query: 1338 AKLEMAQLKSDL 1349
A +L+ +L
Sbjct: 1896 ANASRRKLQREL 1907
Score = 77.8 bits (183), Expect = 4e-13
Identities = 201/1089 (18%), Positives = 407/1089 (37%), Gaps = 89/1089 (8%)
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
++ E +KV G E+ + R Q LE + L EQL+ E A +++
Sbjct: 854 LQAKDEELLKVKEKQTKVEGELEE---MERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 571 PPTFLDKQVMTDNIVTCD--IHESETVTNSIQN---KM---IHAASTPSSKEKSDSPPLS 622
KQ + + + + + E E +QN KM I +E+ L
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 623 IDKTTEETQF---HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRK 679
++K T E + ++ L N + R+ E + L + +K A+ R
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 680 LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALK 739
++ +E +EK E + A+ KL + E T L+ ++ EL+ + LK
Sbjct: 1031 KQEVMISD---LEERLKKEEKTRQELEKAKRKL-----DGETTDLQDQIAELQAQIDELK 1082
Query: 740 KQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERD 799
Q+ + ++ + G + T ++ + + ++ L+++ + + + E+
Sbjct: 1083 LQLAKKEEELQGAL--ARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 800 CERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE 859
L EL KT ++ + QQ + KR+ +V E + + L +T++ EA +
Sbjct: 1141 KRDLSEELEAL----KTELEDTLDTTAAQQELRTKREQEVAELKKA-LEEETKNHEAQIQ 1195
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMI-CQDEKSE 917
++ + L + ++ L K N +K Q LE + KE ++K L+ + + E
Sbjct: 1196 DMR-QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 918 KK----VRFTEATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
KK V+ A E D L+ + + + +K KD A
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 972 FKPRIPKKPTDLTT--KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
+ + ++ T KL L + LE E + + +E A+ LEK++
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE------EEEEARKNLEKQVLA 1368
Query: 1030 IRSKLSKNDSEFTNEKNRLQT-EIAK---LKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
++S+L+ + ++ +++ E AK LKD A L + A Y LE + L
Sbjct: 1369 LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA-LSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 1086 QCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ 1145
+ LT ++ ++ + L K L
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487
Query: 1146 VDN-YTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
+ + + K + ++ + D +EK + +V
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDE----LQARFIKTESKFITLEAEMRDLKADYEN 1260
+ + RL + + + K + LQ R + E K L ++R+L+A+ E+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 1261 KITSLESTIAAK---DVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXX 1317
+ +A+K ++ +K LE + + N DE + ++ +
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQI-EAANKARDEVIKQLRKLQAQMKDY--------- 1657
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
Q EL A+ ++ A+S ++ ++ L++++ +L+ + A
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER---DELA 1714
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E+ + LD R +A +A L+ +L+ + N R + +
Sbjct: 1715 DEITNSASGKSALLDEKR--------RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ- 1765
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
V L LA E++ ++ + LE ++ KA+L + + + L
Sbjct: 1766 ---VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK 1822
Query: 1498 LGEIKTLQEKLGTESAAWN-----TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+G+++ E+ E AA N TEK + + ER ++ + + NAR+ Q
Sbjct: 1823 IGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL 1882
Query: 1553 ERELRAAND 1561
+R+L A +
Sbjct: 1883 KRQLEEAEE 1891
Score = 57.6 bits (133), Expect = 4e-07
Identities = 92/479 (19%), Positives = 189/479 (39%), Gaps = 32/479 (6%)
Query: 1329 EKTEAESSAAKLEMAQLKSDL-AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
E+ A +A K E+ ++ DL +++E ++ ++ ++LD + +
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-EGA 965
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
R+KL ++ + +K + E+ L+ + + RI E + E +K ++
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
+ + ++ E L++E T+ L K + GE +Q +++ +I L+ +
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEK-TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERAR-LNARLDQRERELRAANDRRDVL 1566
L + + E+Q ++A + ++ R L A++ + + + + R+
Sbjct: 1085 LAKK-------EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 1567 EHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEI 1626
E D + Q+ +E+ K +A+I
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA---LEEETKNHEAQI 1194
Query: 1627 TDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMA-EIK--NGDKSAR 1683
D + R+ + + ++L+ Q RF+ + KQ LE K +A E+K K+
Sbjct: 1195 QDMRQRHATALEELSEQLE----QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 1684 IHRNSISSTDEEEYRNKVA-------LLEQQVACLEDELCE-SRLL--ASKLNTELVSEK 1733
H+ +E KV+ L ++ + L++EL S LL A K + +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 1734 SSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLA 1792
+S E +L + Q L E ++L S R R + L +E +E+ R E LA
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLE-EEKNSLQEQQEEEEEARKNLEKQVLA 1368
Score = 39.9 bits (89), Expect = 0.091
Identities = 41/169 (24%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Query: 1619 EKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNG 1678
EK AE +T + MR L + ++ + ++ +E ++ ++N
Sbjct: 888 EKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES---RVEEEEERNQILQNE 944
Query: 1679 DKSARIHRNSISST-DEEE-YRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA 1736
K + H + DEEE R K+ L + ++ E LL N++ + EK
Sbjct: 945 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004
Query: 1737 EVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKERDEQQRL 1784
E R+AE S+L E EE+ + L+ R + + + +E KE +Q L
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
>AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein
protein.
Length = 2018
Score = 113 bits (271), Expect = 8e-24
Identities = 183/897 (20%), Positives = 378/897 (42%), Gaps = 77/897 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR---RLANIDTANKYTTGRSSE 318
+D + QDQI L+ ++D L+ + + E+E L R + + A K ++
Sbjct: 1102 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1161
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ +LQ+ +K+ L++++ +++ELE T A +++ R + +A
Sbjct: 1162 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA-- 1219
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
L + L +E ++ + +++D+ + E Q ++ + LE KN + L
Sbjct: 1220 ELKKALEEETKNHEAQIQDMRQRHATALEELSE-QLEQAKRFKANLE---KNKQGLETDN 1275
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
K+ + L+Q KAE E K ++ + +++EL +V+ RL+ ELAE
Sbjct: 1276 KELACEVKVLQQVKAESEHKRKKL---------DAQVQELHAKVSEGD----RLRVELAE 1322
Query: 499 ANSKFTG--SNPS-LMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
SK N S L++ + + +K ++ + + +D +L LQ+ ++ +L +
Sbjct: 1323 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL---LQEETRQKLNLSSR 1379
Query: 556 LRNAEEETANCKQVNPP-----TFLDKQVM--------TDNIVTCDIHESETVTNSIQNK 602
+R EEE + ++ L+KQV+ T V D+ E++ + +
Sbjct: 1380 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1439
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSI-FNHMAANNLRKTAARVEE-- 659
+ A + E+ ++KT Q D + + A+NL K + ++
Sbjct: 1440 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1499
Query: 660 -DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
+ +S+ + + +A + A L+ + KE E +++ +E
Sbjct: 1500 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1559
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEE 777
+ + V ELE+ K AL++QV+E+ +++ + + A + R + + K E
Sbjct: 1560 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1619
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R DE +E +K+L+ K+ L AEL +K+ + S+ D + DL+ Q+
Sbjct: 1620 RDLQTRDEQNEEKKRLLIKQ--VRELEAELEDERKQRALAVASKKKMEIDLK--DLEAQI 1675
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKN---AKSLRSDKALDLNTKKTTQLE 894
+ + + + + L+A + Q E ++ + ++ A+S S+K L + QL+
Sbjct: 1676 EAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1735
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
E LA + + E+ E T + ++ L K+
Sbjct: 1736 EE----LASSERARRHAEQERDELADEITNSASGKSALLDEKR----RLEARIAQLEEEL 1787
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q+ ++ L D +K+ ++ +L + + ++ ++ +K A L
Sbjct: 1788 EEEQSNMELLNDRFRKT-TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK-AKLQE 1845
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNE------KNRL--QTEIAKLKDVNAKLEGDK 1066
E K+K + I + +K+ + + + E N+L +TE KLK++ ++E D+
Sbjct: 1846 LEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE-KKLKEIFMQVE-DE 1903
Query: 1067 DVFANKYK-ALENENS---NLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
A++YK +E N+ L Q + EE A KL +L +AT +S
Sbjct: 1904 RRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1960
Score = 93.5 bits (222), Expect = 7e-18
Identities = 193/1095 (17%), Positives = 427/1095 (38%), Gaps = 75/1095 (6%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKK---QVKELTSKISSVT--KTSAGSNTTA 763
++K LL++ QE L+ K EEL + KE K +++E+ K + K A
Sbjct: 882 KVKPLLQVTRQEEE-LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 940
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL 823
L + ++ R+ + E++E+ L + + E + L +KK + I+
Sbjct: 941 ETELFAEAEEM-RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 999
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKAL 883
+++ K QL+ + E AK + +E + L+ +N K +K K L D+
Sbjct: 1000 QLDEEEGARQKLQLEKVTAE-----AKIKKMEEEILLLEDQNSK--FIKE-KKLMEDRIA 1051
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ +++ E E + LAKI+ + + + E++++ E T++E + K K
Sbjct: 1052 ECSSQLAE--EEEKAKNLAKIRNKQEVMISD-LEERLKKEEKTRQELEKAKRKLDGETTD 1108
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
LK ++ + + + + K K+V +L+ +I E+
Sbjct: 1109 LQDQIAELQAQID---ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1165
Query: 1004 YVVMKNAGLS-GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
++ S K K L +E++ ++++L ++ + T + L+T K + A+L
Sbjct: 1166 QEDFESEKASRNKAEKQKRDLSEELEALKTEL-EDTLDTTAAQQELRT---KREQEVAEL 1221
Query: 1063 EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL-KNATSLQTTMSDC 1121
K + K E + ++ + T EE+ + Q + A+L KN L+T +
Sbjct: 1222 ---KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1278
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
QV + ++L E+ +K K+ +
Sbjct: 1279 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1338
Query: 1182 XXCK----RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQ 1234
+ + K ++ + ++ Q + L++ R+L E L +++E +
Sbjct: 1339 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1398
Query: 1235 ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK---Y 1291
E + + L++++ D K ++ + ++ES AK +K E AL Q +K Y
Sbjct: 1399 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE-ALSQRLEEKALAY 1457
Query: 1292 DEATSPVEMVEMR-XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
D+ ++ L + K ++ AE + A+ + D A
Sbjct: 1458 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAE-ERDRA 1516
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELA 1410
+ E + +AKE + + Q+++ + D + KD K+
Sbjct: 1517 EAEAREKETKALSLARALEEAL---EAKE-EFERQNKQLRADMEDLMSSKDDVGKNVH-- 1570
Query: 1411 TLKGKLKILEQNSGAGAKRITELKQEY---EETVKKLEHSLALEKAEYEELTGKYELLEE 1467
L+ + LEQ ++ EL+ E E+ +LE ++ KA++E + +E
Sbjct: 1571 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQTRDE 1627
Query: 1468 EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQN 1524
++ K L + + + EL +K+ + A+ K ++ + L + A N + E+
Sbjct: 1628 QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1687
Query: 1525 SIASLQERLCGGGWEVERARLNAR---LDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
+ LQ ++ E+E AR + +E E + + ++L+ +
Sbjct: 1688 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA--- 1744
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
R ++ +R ++ +AR A++ + + M +
Sbjct: 1745 ------RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1798
Query: 1642 DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
D + QV E + + + + +++ +K + + + +++ +
Sbjct: 1799 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1858
Query: 1702 ALLEQQVACLEDEL---CESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
+ LE ++ LE++L + R A+KL + +++ + + ++Y+E+ +
Sbjct: 1859 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ--MEK 1916
Query: 1759 GRARVAGLATRMELA 1773
AR+ L ++E A
Sbjct: 1917 ANARMKQLKRQLEEA 1931
Score = 82.2 bits (194), Expect = 2e-14
Identities = 178/932 (19%), Positives = 358/932 (38%), Gaps = 68/932 (7%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK 711
K A++ E ++ L++ K + KL ET + D+ +A E+K
Sbjct: 1065 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1124
Query: 712 LLLELNEQEAT-VLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L L E+E L R +E ALK V+EL ++I+ + + S +R
Sbjct: 1125 LQLAKKEEELQGALARGDDETLHKNNALKV-VRELQAQIAEL-QEDFESEKASRNKAEKQ 1182
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
L+EE ++ L+ E+++ ++ + E++ +K + K+ D +
Sbjct: 1183 KRDLSEE-LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1241
Query: 831 ------VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
+L QL+ ++ + L Q LE DN++L E K LQ +K A+S K LD
Sbjct: 1242 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK-AESEHKRKKLD 1300
Query: 885 -----LNTK--KTTQLENELKEALAKIK-ELEMICQ--DEKSEKKVRFTEATKKETDTLK 934
L+ K + +L EL E +K++ EL+ + +E +K ++F + L+
Sbjct: 1301 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1360
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE 994
Q + SL++ ++ + R + L + QL +
Sbjct: 1361 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1420
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKND---SEFTNEKNRLQTE 1051
++ ++G + + + AK KL K+ + + +L + + KNRLQ E
Sbjct: 1421 KVDDDLGTIESLEE----------AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1470
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
L D+ L+ + V +N K + + L+ + + R+ + A
Sbjct: 1471 ---LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1527
Query: 1112 TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD----NYTKIDQDKNKLLKEVGDKT 1167
SL + + + D N ++++ K L ++V +
Sbjct: 1528 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1587
Query: 1168 KKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV-VLANTHRRLSIEL 1226
++ + R+E + K + + +L R L EL
Sbjct: 1588 TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1647
Query: 1227 TSEKDELQARFIKTESKFITLEAEMRDLKADYE--NK-----ITSLESTIAAKDVHIKQL 1279
+DE + R + SK +E +++DL+A E NK I L A + ++L
Sbjct: 1648 ---EDERKQRALAVASK-KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1703
Query: 1280 EDA-------LRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE 1332
E+A Q+ + + E+++++ + E + ++ +
Sbjct: 1704 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1763
Query: 1333 AESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER---K 1389
+ SA E +L++ +A+LE + L+ +L +ER +
Sbjct: 1764 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1823
Query: 1390 KLDRMRIAHDKDVKNKDAELATLKGKLKI-LEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
K D R ++ K A+L L+G +K + A +I +L+++ E+ K+ +
Sbjct: 1824 KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAAN 1883
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE---IKTLQ 1505
L + ++L + +E+E + + E+A + ++++L A E +
Sbjct: 1884 KLVRRTEKKLKEIFMQVEDERRHAD-QYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1942
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGG 1537
KL E + +++L+ RL GG
Sbjct: 1943 RKLQRELDDATEANEGLSREVSTLKNRLRRGG 1974
Score = 80.6 bits (190), Expect = 5e-14
Identities = 206/1092 (18%), Positives = 429/1092 (39%), Gaps = 89/1092 (8%)
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+L++ ++ EL +E+L K+ T+ +E ELE Q + + + A+ L AE
Sbjct: 886 LLQVTRQEEELQAKDEELLKVKEKQTK----VEGELEEMERKHQQLLEEKNILAEQLQAE 941
Query: 379 TLCEELMDENEDMKKEL----RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
T EL E E+M+ L ++L ++ E++ + L+ E ++ + + L
Sbjct: 942 T---ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE-ERNQILQNEKKKMQAHIQDL 997
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENR--IKELEQEVARSTEVALRL 492
+L + E +L+ EK E K+ ++ ++ +N IKE + R E + +L
Sbjct: 998 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1057
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
E +A + N + + E ++ + TR ++ +L + D ++ A+L
Sbjct: 1058 AEEEEKAKNLAKIRNKQEVMISDLEE-RLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL 1116
Query: 553 REQLRNAEEETANCKQVNPPTFL--DKQVMTDNIVTCDIHESETVTNSIQN--KMIHAAS 608
+ Q+ + + A ++ D + + N + E + +Q + A+
Sbjct: 1117 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1176
Query: 609 TPSSKEKSD-SPPLSIDKTTEETQFHFDLPY--LSIFNHMAANNLRKTAARVEEDNESLL 665
+ K+K D S L KT E L L+K +++E+ +
Sbjct: 1177 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1236
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPA-EMKLLLEL---NEQEA 721
+++ A A + + ETD + A E+K+L ++ +E +
Sbjct: 1237 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1296
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
L +V+EL + EL K S + + + +T K A++
Sbjct: 1297 KKLDAQVQELHAKVSEGDRLRVELAEKASKL-QNELDNVSTLLEEAEKKGIKFAKDAAS- 1354
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE 841
LE ++ + ++ L E+ R L + + +++ +L + + + ++N L++Q+ ++
Sbjct: 1355 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN--LEKQVLALQ 1412
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLR---SDKAL--DLNTKKTTQLENE 896
+ + + K E L+ KK LLK+A++L +KAL D K +L+ E
Sbjct: 1413 SQLADTKKKVDDDLGTIESLEEAKKK--LLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1470
Query: 897 LKEALAKIKELEMICQD-EKSEKK------------VRFTEATKKETDTLKSKQXXXXXX 943
L + + + + EK +KK R+ E + + K+
Sbjct: 1471 LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1530
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQ--KSFKPRIPKKPTDL-TTKLQLKKMVEDLECEI 1000
+ K L+ D + S K + K +L +K L++ VE++ ++
Sbjct: 1531 ARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL 1590
Query: 1001 GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKN---DSEFTNEKNRLQTEIAKLKD 1057
E+ L E AK +LE + ++++ ++ E EK RL I ++++
Sbjct: 1591 EEL-----EDELQATE-DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL--IKQVRE 1642
Query: 1058 VNAKLEGDKD----VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN-AT 1112
+ A+LE ++ A+K K +E + +L Q + + Q+ KL A +K+
Sbjct: 1643 LEAELEDERKQRALAVASK-KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1701
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD 1172
L+ + + ++ + +E + +I +
Sbjct: 1702 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1761
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+R+E +++ ++ + + L+ EL +E+
Sbjct: 1762 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1821
Query: 1233 LQARFIKTESKFITLEAEMRDLKA---DYENKITS-LESTIAAKDVHIKQLEDALRQ--- 1285
Q K+++ LE + ++LKA + E + S ++TI+A + I QLE+ L Q
Sbjct: 1822 AQ----KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1877
Query: 1286 ---TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK-----LEKTEAESSA 1337
N ++ + M+ Q E NA++K LE+ E E++
Sbjct: 1878 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1937
Query: 1338 AKLEMAQLKSDL 1349
A +L+ +L
Sbjct: 1938 ANASRRKLQREL 1949
Score = 77.8 bits (183), Expect = 4e-13
Identities = 201/1089 (18%), Positives = 407/1089 (37%), Gaps = 89/1089 (8%)
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
++ E +KV G E+ + R Q LE + L EQL+ E A +++
Sbjct: 896 LQAKDEELLKVKEKQTKVEGELEE---MERKHQQLLEEKNILAEQLQAETELFAEAEEMR 952
Query: 571 PPTFLDKQVMTDNIVTCD--IHESETVTNSIQN---KM---IHAASTPSSKEKSDSPPLS 622
KQ + + + + + E E +QN KM I +E+ L
Sbjct: 953 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 1012
Query: 623 IDKTTEETQF---HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRK 679
++K T E + ++ L N + R+ E + L + +K A+ R
Sbjct: 1013 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1072
Query: 680 LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALK 739
++ +E +EK E + A+ KL + E T L+ ++ EL+ + LK
Sbjct: 1073 KQEVMISD---LEERLKKEEKTRQELEKAKRKL-----DGETTDLQDQIAELQAQIDELK 1124
Query: 740 KQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERD 799
Q+ + ++ + G + T ++ + + ++ L+++ + + + E+
Sbjct: 1125 LQLAKKEEELQGAL--ARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1182
Query: 800 CERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE 859
L EL KT ++ + QQ + KR+ +V E + + L +T++ EA +
Sbjct: 1183 KRDLSEELEAL----KTELEDTLDTTAAQQELRTKREQEVAELKKA-LEEETKNHEAQIQ 1237
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMI-CQDEKSE 917
++ + L + ++ L K N +K Q LE + KE ++K L+ + + E
Sbjct: 1238 DMR-QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1296
Query: 918 KK----VRFTEATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
KK V+ A E D L+ + + + +K KD A
Sbjct: 1297 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1356
Query: 972 FKPRIPKKPTDLTT--KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
+ + ++ T KL L + LE E + + +E A+ LEK++
Sbjct: 1357 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE------EEEEARKNLEKQVLA 1410
Query: 1030 IRSKLSKNDSEFTNEKNRLQT-EIAK---LKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
++S+L+ + ++ +++ E AK LKD A L + A Y LE + L
Sbjct: 1411 LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA-LSQRLEEKALAYDKLEKTKNRLQQ 1469
Query: 1086 QCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ 1145
+ LT ++ ++ + L K L
Sbjct: 1470 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1529
Query: 1146 VDN-YTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
+ + + K + ++ + D +EK + +V
Sbjct: 1530 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1589
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDE----LQARFIKTESKFITLEAEMRDLKADYEN 1260
+ + RL + + + K + LQ R + E K L ++R+L+A+ E+
Sbjct: 1590 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1649
Query: 1261 KITSLESTIAAK---DVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXX 1317
+ +A+K ++ +K LE + + N DE + ++ +
Sbjct: 1650 ERKQRALAVASKKKMEIDLKDLEAQI-EAANKARDEVIKQLRKLQAQMKDY--------- 1699
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
Q EL A+ ++ A+S ++ ++ L++++ +L+ + A
Sbjct: 1700 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER---DELA 1756
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E+ + LD R +A +A L+ +L+ + N R + +
Sbjct: 1757 DEITNSASGKSALLDEKR--------RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ- 1807
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
V L LA E++ ++ + LE ++ KA+L + + + L
Sbjct: 1808 ---VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK 1864
Query: 1498 LGEIKTLQEKLGTESAAWN-----TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+G+++ E+ E AA N TEK + + ER ++ + + NAR+ Q
Sbjct: 1865 IGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL 1924
Query: 1553 ERELRAAND 1561
+R+L A +
Sbjct: 1925 KRQLEEAEE 1933
Score = 57.6 bits (133), Expect = 4e-07
Identities = 92/479 (19%), Positives = 189/479 (39%), Gaps = 32/479 (6%)
Query: 1329 EKTEAESSAAKLEMAQLKSDL-AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
E+ A +A K E+ ++ DL +++E ++ ++ ++LD + +
Sbjct: 949 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-EGA 1007
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
R+KL ++ + +K + E+ L+ + + RI E + E +K ++
Sbjct: 1008 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1067
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
+ + ++ E L++E T+ L K + GE +Q +++ +I L+ +
Sbjct: 1068 AKIRNKQEVMISDLEERLKKEEK-TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1126
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERAR-LNARLDQRERELRAANDRRDVL 1566
L + + E+Q ++A + ++ R L A++ + + + + R+
Sbjct: 1127 LAKK-------EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1179
Query: 1567 EHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEI 1626
E D + Q+ +E+ K +A+I
Sbjct: 1180 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA---LEEETKNHEAQI 1236
Query: 1627 TDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMA-EIK--NGDKSAR 1683
D + R+ + + ++L+ Q RF+ + KQ LE K +A E+K K+
Sbjct: 1237 QDMRQRHATALEELSEQLE----QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1292
Query: 1684 IHRNSISSTDEEEYRNKVA-------LLEQQVACLEDELCE-SRLL--ASKLNTELVSEK 1733
H+ +E KV+ L ++ + L++EL S LL A K + +
Sbjct: 1293 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1352
Query: 1734 SSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLA 1792
+S E +L + Q L E ++L S R R + L +E +E+ R E LA
Sbjct: 1353 ASLESQLQDTQELLQEETRQKLNLSSRIRQLE-EEKNSLQEQQEEEEEARKNLEKQVLA 1410
Score = 39.9 bits (89), Expect = 0.091
Identities = 41/169 (24%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Query: 1619 EKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNG 1678
EK AE +T + MR L + ++ + ++ +E ++ ++N
Sbjct: 930 EKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES---RVEEEEERNQILQNE 986
Query: 1679 DKSARIHRNSISST-DEEE-YRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA 1736
K + H + DEEE R K+ L + ++ E LL N++ + EK
Sbjct: 987 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1046
Query: 1737 EVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKERDEQQRL 1784
E R+AE S+L E EE+ + L+ R + + + +E KE +Q L
Sbjct: 1047 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1095
>BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 112 bits (269), Expect = 1e-23
Identities = 182/878 (20%), Positives = 379/878 (43%), Gaps = 87/878 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR---RLANIDTANKYTTGRSSE 318
+D + QDQI L+ ++D L+ + + E+E L R + + A K ++
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ +LQ+ +K+ L++++ +++ELE T A +++ R + +A
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA-- 1177
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
L + L +E ++ + +++D+ + E Q ++ + LE KN + L
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSE-QLEQAKRFKANLE---KNKQGLETDN 1233
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
K+ + L+Q KAE E K ++ + +++EL +V+ RL+ ELAE
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKL---------DAQVQELHAKVSEGD----RLRVELAE 1280
Query: 499 ANSKFTG--SNPS-LMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
SK N S L++ + + +K ++ + + +D +L LQ+ ++ +L +
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL---LQEETRQKLNLSSR 1337
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
+R EEE + ++ ++ + ++ ++T + + + S +K+K
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT-KKKVDDDLGTIESLEEAKKK 1396
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL---KKMA 672
++ + EE +D L KT R++++ + L + L +++A
Sbjct: 1397 LLKDAEALSQRLEEKALAYD-------------KLEKTKNRLQQEPDDLTVDLDHQRQVA 1443
Query: 673 TK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEEL 731
+ + +K A + SI +A +E++ EA+ E E +A L R +EE
Sbjct: 1444 SNLEKKQKKFDQLLAEEKSI-SARYAEERDRAEAEARE-------KETKALSLARALEEA 1495
Query: 732 EQDKEALKKQVKELTSKISSV--TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
+ KE ++Q K+L + + + +K G N S + E++V+ + +++E+
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE----LEKSKRALEQQVEEMRTQLEEL 1551
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL--QVIEQEASVL 847
+L + + +L E+++ K + R L D+QN + KR L QV E EA +
Sbjct: 1552 EDEL--QATEDAKLRLEVNMQAMKAQF---ERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 848 RAKTQS--LEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL---ENELKEALA 902
+ Q A +K++ + K L+ A + D+ + K Q+ + EL+EA A
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
E+ Q ++SEKK++ EA + + A+ K
Sbjct: 1667 SRDEI--FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG------KE 1016
S D ++ + RI + +L + +++ D + V NA L+ K
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLND-RFRKTTLQVDTLNAELAAERSAAQKS 1783
Query: 1017 MTAKTKLEKEIDEIRSKLSKND----SEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANK 1072
A+ +LE++ E+++KL + + S+F + L+ +I +L++ + E + ANK
Sbjct: 1784 DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE-QLEQEAKERAAANK 1842
Query: 1073 -YKALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+ E + + Q + + Q+ K +A +K
Sbjct: 1843 LVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880
Score = 95.1 bits (226), Expect = 2e-18
Identities = 174/877 (19%), Positives = 384/877 (43%), Gaps = 64/877 (7%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCE-RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+++E D+ EG +Q++ + + E +++K + +ILL D +K+ + ++
Sbjct: 954 DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLE----DQNSKFIKEKKLMEDRIA 1009
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
+ ++L E ++ K + K + S+LE R E +TRQ + + L ET +
Sbjct: 1010 ECSSQLAEEEEKAKNLAK-IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT--D 1066
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFR-------EDQADEYSSLR--RELEQTIKNCRVL 434
L D+ +++ ++ +L ++ + ++ + ++L+ REL+ I +
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE- 1125
Query: 435 SFKLKKTER-KADQLEQEKAEHEKKL---LEIVGGPDGMQRENRIKELEQEVARSTEVAL 490
F+ +K R KA++ +++ +E + L LE Q+E R K EQEVA E+
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR-EQEVA---ELKK 1181
Query: 491 RLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L+ E ++ + + ++ ++ + +++ L D ++ L E
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE-LACEV 1240
Query: 551 DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+ +Q++ AE E K L +V + + ++ E + +QN++ + ++
Sbjct: 1241 KVLQQVK-AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK---ASKLQNELDNVSTLL 1296
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
EK + D + E+Q D L NL ++EE+ SL Q ++
Sbjct: 1297 EEAEKKGIK-FAKDAASLESQLQ-DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV-- 728
++ + ++L+ +D+ T E+ K LL+ E + L K
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414
Query: 729 -EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR------SLTTNSNKLAEERVKV 781
++LE+ K L+++ +LT + + ++ ++ + S + AEER +
Sbjct: 1415 YDKLEKTKNRLQQEPDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474
Query: 782 LEDEIDEVRKKLIEKERDCER-LHAELSLAQKKPKTLIKSRSLDASDQ---QNV-DLKRQ 836
E E E K + R E L A+ ++ + L +S +NV +L++
Sbjct: 1475 -EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKS 1533
Query: 837 LQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
+ +EQ+ +R + + LE +E TE+ KL+L N +++++ DL T + Q E +
Sbjct: 1534 KRALEQQVEEMRTQLEELE--DELQATEDAKLRLEVNMQAMKAQFERDLQT-RDEQNEEK 1590
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
+ + +++ELE +DE+ ++ + K E D LK +
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEID-LKDLEAQIEAANKARDEVIKQLRK 1649
Query: 957 XQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
QA +K D Q+ + + + +K ++ LE EI ++ + ++ + +
Sbjct: 1650 LQAQMK----DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK-- 1074
A+ + ++ DEI + S S +EK RL+ IA+L++ + + + ++ ++++
Sbjct: 1706 --AEQERDELADEITNSAS-GKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT 1762
Query: 1075 --ALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
++ N+ L+ + ++ ++ N Q+ + + +LK
Sbjct: 1763 TLQVDTLNAELAAE-RSAAQKSDNARQQLERQNKELK 1798
Score = 93.5 bits (222), Expect = 7e-18
Identities = 193/1095 (17%), Positives = 427/1095 (38%), Gaps = 75/1095 (6%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKK---QVKELTSKISSVT--KTSAGSNTTA 763
++K LL++ QE L+ K EEL + KE K +++E+ K + K A
Sbjct: 840 KVKPLLQVTRQEEE-LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL 823
L + ++ R+ + E++E+ L + + E + L +KK + I+
Sbjct: 899 ETELFAEAEEM-RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKAL 883
+++ K QL+ + E AK + +E + L+ +N K +K K L D+
Sbjct: 958 QLDEEEGARQKLQLEKVTAE-----AKIKKMEEEILLLEDQNSK--FIKE-KKLMEDRIA 1009
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ +++ E E + LAKI+ + + + E++++ E T++E + K K
Sbjct: 1010 ECSSQLAE--EEEKAKNLAKIRNKQEVMISD-LEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
LK ++ + + + + K K+V +L+ +I E+
Sbjct: 1067 LQDQIAELQAQID---ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 1004 YVVMKNAGLS-GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
++ S K K L +E++ ++++L ++ + T + L+T K + A+L
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTEL-EDTLDTTAAQQELRT---KREQEVAEL 1179
Query: 1063 EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL-KNATSLQTTMSDC 1121
K + K E + ++ + T EE+ + Q + A+L KN L+T +
Sbjct: 1180 ---KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
QV + ++L E+ +K K+ +
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 1182 XXCK----RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQ 1234
+ + K ++ + ++ Q + L++ R+L E L +++E +
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 1235 ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK---Y 1291
E + + L++++ D K ++ + ++ES AK +K E AL Q +K Y
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE-ALSQRLEEKALAY 1415
Query: 1292 DEATSPVEMVEMR-XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
D+ ++ L + K ++ AE + A+ + D A
Sbjct: 1416 DKLEKTKNRLQQEPDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAE-ERDRA 1474
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELA 1410
+ E + +AKE + + Q+++ + D + KD K+
Sbjct: 1475 EAEAREKETKALSLARALEEAL---EAKE-EFERQNKQLRADMEDLMSSKDDVGKNVH-- 1528
Query: 1411 TLKGKLKILEQNSGAGAKRITELKQEY---EETVKKLEHSLALEKAEYEELTGKYELLEE 1467
L+ + LEQ ++ EL+ E E+ +LE ++ KA++E + +E
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQTRDE 1585
Query: 1468 EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQN 1524
++ K L + + + EL +K+ + A+ K ++ + L + A N + E+
Sbjct: 1586 QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645
Query: 1525 SIASLQERLCGGGWEVERARLNAR---LDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
+ LQ ++ E+E AR + +E E + + ++L+ +
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA--- 1702
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
R ++ +R ++ +AR A++ + + M +
Sbjct: 1703 ------RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756
Query: 1642 DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
D + QV E + + + + +++ +K + + + +++ +
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 1702 ALLEQQVACLEDEL---CESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
+ LE ++ LE++L + R A+KL + +++ + + ++Y+E+ +
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ--MEK 1874
Query: 1759 GRARVAGLATRMELA 1773
AR+ L ++E A
Sbjct: 1875 ANARMKQLKRQLEEA 1889
Score = 77.8 bits (183), Expect = 4e-13
Identities = 205/1092 (18%), Positives = 428/1092 (39%), Gaps = 89/1092 (8%)
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+L++ ++ EL +E+L K+ T+ +E ELE Q + + + A+ L AE
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTK----VEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 379 TLCEELMDENEDMKKEL----RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
T EL E E+M+ L ++L ++ E++ + L+ E ++ + + L
Sbjct: 900 T---ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE-ERNQILQNEKKKMQAHIQDL 955
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENR--IKELEQEVARSTEVALRL 492
+L + E +L+ EK E K+ ++ ++ +N IKE + R E + +L
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
E +A + N + + E ++ + TR ++ +L + D ++ A+L
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEE-RLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL 1074
Query: 553 REQLRNAEEETANCKQVNPPTFL--DKQVMTDNIVTCDIHESETVTNSIQN--KMIHAAS 608
+ Q+ + + A ++ D + + N + E + +Q + A+
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134
Query: 609 TPSSKEKSD-SPPLSIDKTTEETQFHFDLPY--LSIFNHMAANNLRKTAARVEEDNESLL 665
+ K+K D S L KT E L L+K +++E+ +
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPA-EMKLLLEL---NEQEA 721
+++ A A + + ETD + A E+K+L ++ +E +
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
L +V+EL + EL K S + + + +T K A++
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKL-QNELDNVSTLLEEAEKKGIKFAKDAAS- 1312
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE 841
LE ++ + ++ L E+ R L + + +++ +L + + + ++N L++Q+ ++
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN--LEKQVLALQ 1370
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLR---SDKAL--DLNTKKTTQLENE 896
+ + + K E L+ KK LLK+A++L +KAL D K +L+ E
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKK--LLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428
Query: 897 LKEALAKIKELEMICQD-EKSEKK------------VRFTEATKKETDTLKSKQXXXXXX 943
+ + + + EK +KK R+ E + + K+
Sbjct: 1429 PDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1488
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQ--KSFKPRIPKKPTDL-TTKLQLKKMVEDLECEI 1000
+ K L+ D + S K + K +L +K L++ VE++ ++
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL 1548
Query: 1001 GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKN---DSEFTNEKNRLQTEIAKLKD 1057
E+ L E AK +LE + ++++ ++ E EK RL I ++++
Sbjct: 1549 EEL-----EDELQATE-DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL--IKQVRE 1600
Query: 1058 VNAKLEGDKD----VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN-AT 1112
+ A+LE ++ A+K K +E + +L Q + + Q+ KL A +K+
Sbjct: 1601 LEAELEDERKQRALAVASK-KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD 1172
L+ + + ++ + +E + +I +
Sbjct: 1660 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+R+E +++ ++ + + L+ EL +E+
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779
Query: 1233 LQARFIKTESKFITLEAEMRDLKA---DYENKITS-LESTIAAKDVHIKQLEDALRQ--- 1285
Q K+++ LE + ++LKA + E + S ++TI+A + I QLE+ L Q
Sbjct: 1780 AQ----KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1835
Query: 1286 ---TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK-----LEKTEAESSA 1337
N ++ + M+ Q E NA++K LE+ E E++
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1895
Query: 1338 AKLEMAQLKSDL 1349
A +L+ +L
Sbjct: 1896 ANASRRKLQREL 1907
Score = 77.0 bits (181), Expect = 6e-13
Identities = 201/1089 (18%), Positives = 407/1089 (37%), Gaps = 89/1089 (8%)
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
++ E +KV G E+ + R Q LE + L EQL+ E A +++
Sbjct: 854 LQAKDEELLKVKEKQTKVEGELEE---MERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 571 PPTFLDKQVMTDNIVTCD--IHESETVTNSIQN---KM---IHAASTPSSKEKSDSPPLS 622
KQ + + + + + E E +QN KM I +E+ L
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 623 IDKTTEETQF---HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRK 679
++K T E + ++ L N + R+ E + L + +K A+ R
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 680 LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALK 739
++ +E +EK E + A+ KL + E T L+ ++ EL+ + LK
Sbjct: 1031 KQEVMISD---LEERLKKEEKTRQELEKAKRKL-----DGETTDLQDQIAELQAQIDELK 1082
Query: 740 KQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERD 799
Q+ + ++ + G + T ++ + + ++ L+++ + + + E+
Sbjct: 1083 LQLAKKEEELQGAL--ARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 800 CERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE 859
L EL KT ++ + QQ + KR+ +V E + + L +T++ EA +
Sbjct: 1141 KRDLSEELEAL----KTELEDTLDTTAAQQELRTKREQEVAELKKA-LEEETKNHEAQIQ 1195
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMI-CQDEKSE 917
++ + L + ++ L K N +K Q LE + KE ++K L+ + + E
Sbjct: 1196 DMR-QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 918 KK----VRFTEATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
KK V+ A E D L+ + + + +K KD A
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 972 FKPRIPKKPTDLTT--KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
+ + ++ T KL L + LE E + + +E A+ LEK++
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE------EEEEARKNLEKQVLA 1368
Query: 1030 IRSKLSKNDSEFTNEKNRLQT-EIAK---LKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
++S+L+ + ++ +++ E AK LKD A L + A Y LE + L
Sbjct: 1369 LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA-LSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 1086 QCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ 1145
+ LT ++ ++ + L K L
Sbjct: 1428 EPDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487
Query: 1146 VDN-YTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
+ + + K + ++ + D +EK + +V
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDE----LQARFIKTESKFITLEAEMRDLKADYEN 1260
+ + RL + + + K + LQ R + E K L ++R+L+A+ E+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 1261 KITSLESTIAAK---DVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXX 1317
+ +A+K ++ +K LE + + N DE + ++ +
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQI-EAANKARDEVIKQLRKLQAQMKDY--------- 1657
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
Q EL A+ ++ A+S ++ ++ L++++ +L+ + A
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER---DELA 1714
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
E+ + LD R +A +A L+ +L+ + N R + +
Sbjct: 1715 DEITNSASGKSALLDEKR--------RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ- 1765
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
V L LA E++ ++ + LE ++ KA+L + + + L
Sbjct: 1766 ---VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK 1822
Query: 1498 LGEIKTLQEKLGTESAAWN-----TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+G+++ E+ E AA N TEK + + ER ++ + + NAR+ Q
Sbjct: 1823 IGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL 1882
Query: 1553 ERELRAAND 1561
+R+L A +
Sbjct: 1883 KRQLEEAEE 1891
Score = 57.6 bits (133), Expect = 4e-07
Identities = 92/479 (19%), Positives = 189/479 (39%), Gaps = 32/479 (6%)
Query: 1329 EKTEAESSAAKLEMAQLKSDL-AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
E+ A +A K E+ ++ DL +++E ++ ++ ++LD + +
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-EGA 965
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
R+KL ++ + +K + E+ L+ + + RI E + E +K ++
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
+ + ++ E L++E T+ L K + GE +Q +++ +I L+ +
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEK-TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERAR-LNARLDQRERELRAANDRRDVL 1566
L + + E+Q ++A + ++ R L A++ + + + + R+
Sbjct: 1085 LAKK-------EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 1567 EHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEI 1626
E D + Q+ +E+ K +A+I
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA---LEEETKNHEAQI 1194
Query: 1627 TDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMA-EIK--NGDKSAR 1683
D + R+ + + ++L+ Q RF+ + KQ LE K +A E+K K+
Sbjct: 1195 QDMRQRHATALEELSEQLE----QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 1684 IHRNSISSTDEEEYRNKVA-------LLEQQVACLEDELCE-SRLL--ASKLNTELVSEK 1733
H+ +E KV+ L ++ + L++EL S LL A K + +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 1734 SSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLA 1792
+S E +L + Q L E ++L S R R + L +E +E+ R E LA
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLE-EEKNSLQEQQEEEEEARKNLEKQVLA 1368
Score = 39.9 bits (89), Expect = 0.091
Identities = 41/169 (24%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Query: 1619 EKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNG 1678
EK AE +T + MR L + ++ + ++ +E ++ ++N
Sbjct: 888 EKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES---RVEEEEERNQILQNE 944
Query: 1679 DKSARIHRNSISST-DEEE-YRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA 1736
K + H + DEEE R K+ L + ++ E LL N++ + EK
Sbjct: 945 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004
Query: 1737 EVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKERDEQQRL 1784
E R+AE S+L E EE+ + L+ R + + + +E KE +Q L
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
>Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9,
non-muscle protein.
Length = 1960
Score = 108 bits (260), Expect = 2e-22
Identities = 189/869 (21%), Positives = 365/869 (42%), Gaps = 74/869 (8%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
++++E + E +QE++ R++ E + SD + A I ++ K +
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM-------QLAKKE 1082
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
+++ E+ +K +KIRE+ES++ +E Q +E RA AE +
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKIRELESQI-----SELQ-EDLESERASRNKAEKQKRD 1136
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN--CRVLSFKLKKT 441
L +E E +K EL D Q+ R + E + L++ LE+ K ++ + K +
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQE-LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 442 ---ERKADQLEQEKA-----EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
E A+QLEQ K E K+ LE G + N +K L Q S +++
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERG----ELANEVKVLLQGKGDSEHKRKKVE 1251
Query: 494 RELAEANSKFTGSNPSLMKVPQPET-VKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+L E KF ++ T ++V ++T SQ D ++ + +D E+ L
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD-SKSSKLTKDFSALESQL 1310
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAASTP 610
++ +EE N ++++ T L + N + E E ++++ ++ +HA
Sbjct: 1311 QDTQELLQEE--NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 611 SSKEKSDSPPLSIDKTTEETQ--FHFDLPYLSIFNH---MAANNLRKTAARVEEDNESLL 665
K+ DS + +T EE + DL LS + A + L KT R++++ + LL
Sbjct: 1369 MKKKMEDS--VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
+ L A + + L+ E K +E D AE + E +A L
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTIS--AKYAEERDRAEAEA--REKETKALSLA 1482
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
R +EE + K L++ K+ +++ + + + S + E++V+ ++ +
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE--LEKSKRALEQQVEEMKTQ 1540
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
++E+ +L E RL L + + + ++ R + S+++ L RQ++ +E E
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRD-EQSEEKKKQLVRQVREMEAELE 1599
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
R + A +KL+ + K L+ ++ + D+A+ K+ +L+ ++K+ + +
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI----KQLRKLQAQMKDCM---R 1652
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
EL+ D ++ ++ +A + E LKS + Q L
Sbjct: 1653 ELD----DTRASREEILAQAKENEKK-LKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 966 DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
D+ S K L K +L+ + LE E+ E N L + K
Sbjct: 1708 DEIANSSG----KGALALEEKRRLEARIAQLEEELEEE---QGNTELINDRLK---KANL 1757
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK----ALENENS 1081
+ID+I + L+ S +N Q + K++ KL+ + +KYK ALE + +
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 1082 NLSNQCKTLTEEMKNREAQINKLSADLKN 1110
L Q T+E + Q+ + LK+
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKD 1846
Score = 93.9 bits (223), Expect = 5e-18
Identities = 214/1119 (19%), Positives = 436/1119 (38%), Gaps = 106/1119 (9%)
Query: 277 KQEVDILRKRCERVE-KEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+QE +++ K E V+ +EK RL ++T ++ + Q EL E+
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 901
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKEL 395
LR Q++ EI +LE R E E C+ L E + M++ +
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEE----------------EERCQHLQAEKKKMQQNI 945
Query: 396 RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE--KA 453
++L E+Q +E S R++L+ KLKK E + LE + K
Sbjct: 946 QEL------------EEQLEEEESARQKLQLEKVTTEA---KLKKLEEEQIILEDQNCKL 990
Query: 454 EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKV 513
EKKLL E+RI E + E + + LA+ +K L +
Sbjct: 991 AKEKKLL-----------EDRIAEFTTNLTEEEEKS----KSLAKLKNKHEAMITDLEER 1035
Query: 514 PQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPT 573
+ E + TR + D L + + + A+L+ QL EEE
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL-----A 1090
Query: 574 FLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAASTPSSKEKSD-SPPLSIDKTTEET 630
++++ N+ I E E+ + +Q + A+ + K+K D L KT E
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 631 QFHFDLPY--LSIFNHMAANNLRKTAARVEEDNESLLLQLKK---MATKARSRKLSPTPP 685
L N L+KT + +E+ + ++++ A + + +L T
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE-ELEQDKEALKKQVKE 744
K ++E A E E E E+K+LL+ + ++ R+KVE +L++ + + +
Sbjct: 1211 V-KANLEKAKQTLENERGEL-ANEVKVLLQ-GKGDSEHKRKKVEAQLQELQVKFNEGERV 1267
Query: 745 LTSKISSVTKTSAG-SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERL 803
T VTK N T S + + + + LE ++ + ++ L E+ R ++L
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR--QKL 1325
Query: 804 HAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQT 863
L Q + + L+ ++ +L++Q+ + + + ++ K + E +
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 864 ENKKLQLLKNAKSLRSDK---ALDLNTKKTTQLENELKEALAKI-KELEMICQDEKSEKK 919
+KLQ S R ++ A D K T+L+ EL + L + + + C EK +KK
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 920 VRFTEATKK--------ETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
A +K E D +++ +A L+ L +
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 972 FKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNA--GLSGKEMTAKTKLEKEIDE 1029
+ + K + +L+K LE ++ EM ++ L E AK +LE +
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE-DAKLRLEVNLQA 1564
Query: 1030 IRSKLSKN----DSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
++++ ++ D + +K +L + +++++ A+LE ++ + A + +L +
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQL---VRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Query: 1086 QCKTLTEEMKNRE---AQINKLSADLKNA-TSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ KNR+ Q+ KL A +K+ L T +
Sbjct: 1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681
Query: 1142 XXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXX 1201
+ ++ K + +E + +I + +R+E +++ ++ +
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741
Query: 1202 XXXXXXXXXQA----VVLANTHRRLSIELT-SEKDELQARFIKTESKFITLEAEMRD--L 1254
+ + + + L++E + ++K+E + ++ ++K + ++ + + +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV 1801
Query: 1255 KADYENKITSLESTIA----AKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
K+ Y+ IT+LE+ IA D K+ + A +Q + +++ + R
Sbjct: 1802 KSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861
Query: 1311 XXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
L K +LE+ E E+ A +L+ +L
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Score = 89.0 bits (211), Expect = 1e-16
Identities = 206/1075 (19%), Positives = 415/1075 (38%), Gaps = 89/1075 (8%)
Query: 538 LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LL+ + E A E ++ E++ A ++ L Q+M + + + ++ET
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+ ++ A + K++ + ++ EE + +L N+++ ++
Sbjct: 897 AEAEEL--RARLTAKKQELEEICHDLEARVEEEEERCQ--HLQAEKKKMQQNIQELEEQL 952
Query: 658 EEDNESLL-LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
EE+ + LQL+K+ T+A+ +KL ++ +E N KE + + L
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEE----EQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
E+E + + +L+ EA+ + +L ++ K T RR L +S L++
Sbjct: 1009 TEEEEK--SKSLAKLKNKHEAM---ITDLEERLRREEKQRQELEKT-RRKLEGDSTDLSD 1062
Query: 777 ERVKVLEDEIDEVRKKLIEKERDCERLHAELSL-AQKKPKTLIKSRSLDASDQQNVDLKR 835
+ + L+ +I E++ +L +KE + + A + A +K L K R L++ Q +L+
Sbjct: 1063 Q-IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES---QISELQE 1118
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTE-NKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
L+ + + + L + E L+TE L + LRS + ++N K T LE
Sbjct: 1119 DLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT-LE 1177
Query: 895 NELKEALAKIKELEMICQD------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
E K A+I+E+ E+ E+ R +K TL++++
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKP--RIPKKPTDLTTKLQLK---------------- 990
+ +++ + Q F R+ + D TKLQ++
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 991 KMVED---LECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKN 1046
K+ +D LE ++ + +++ ++ K K +E E + R +L + + N +
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 1047 RLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
++ T A++ D+ K+E + E L + L++ + + A +KL
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCL----ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE- 1412
Query: 1107 DLKNATSLQTTMSDCMXXXXXXXXXX----XXXXXXXXXXXXQVDNYTKIDQDKNKLLKE 1162
K T LQ + D + + K +++++ E
Sbjct: 1413 --KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE 1470
Query: 1163 VGDKTKK---IGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+K K + +R+ KQ T + + +
Sbjct: 1471 AREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL 1530
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
+ E+ ++ +EL+ TE + LE ++ +KA +E + + K KQL
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK---KQL 1587
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+R+ + DE V R D N + EA K
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK-----NRDEAIKQLRK 1642
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
L+ AQ+K + +L++ E K K ++ ++ +++L A
Sbjct: 1643 LQ-AQMKDCMRELDDTRASREEILAQAKEN----EKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+ + +D ELA + +SG GA + E K+ E + +LE L E+ E +
Sbjct: 1698 QAQQERD-ELA------DEIANSSGKGALALEE-KRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKT-LQEKLGTESAAWNTE 1518
+ + + L +E+ AQ + + +++L E+K LQE GT + +
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQ-KNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 1519 KTEMQNSIASLQERLCGGGWEVERARLNARLDQRERE--LRAANDRRDVLEHHHD 1571
T ++ IA L+E+L E + A R +++ + L +D R E + D
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Score = 85.4 bits (202), Expect = 2e-15
Identities = 201/980 (20%), Positives = 398/980 (40%), Gaps = 106/980 (10%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E + L K +N E + +ER RR + +E EKT R + S+ D +Q +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
LK + + ++E + QI L+++++ R
Sbjct: 1071 ----IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 287 CERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ-QKVNELTTHNEDLRDEKKHLTQ 345
+ EK+K D+ G E LK + + + T ++LR +++ Q
Sbjct: 1127 RNKAEKQKRDL----------------GEELEALKTELEDTLDSTAAQQELRSKRE---Q 1167
Query: 346 KIREIESELETRPST-EAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXX 404
++ ++ LE T EAQ +++ Q ++ A E L E+L ++ + +K L
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQ--AVEELAEQL-EQTKRVKANL--------- 1215
Query: 405 MQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG 464
+ ++ +E L E++ ++ K KK E + +L+ + E E+ E+
Sbjct: 1216 --EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD 1273
Query: 465 GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
+Q E + + +++S + +L ++ + S+ + L + K+S S
Sbjct: 1274 KVTKLQVE--LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ---EENRQKLSLS 1328
Query: 525 SLTRGGSQEDPAQLLRD-LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
T+ ED R+ L++ E + +L +Q+ + A+ K+ M D+
Sbjct: 1329 --TKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM----------KKKMEDS 1376
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
V C + +E V +Q K + S ++ + L KT + + DL
Sbjct: 1377 -VGC-LETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD-DLLVDLDHQ 1432
Query: 644 HMAANNLRKTAARVEE-DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
+A NL K + ++ E + K + R+ + LS+ A + ++
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 703 DEADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSV-TKTSAGS 759
E + + E+ + ++ + + V ELE+ K AL++QV+E+ +++ + + A
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 760 NTTARRSLTTNSNKLAEER-VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
+ R + + K ER ++ +++ +E +K+L+ + R+ E AEL +K+
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME---AELEDERKQ----- 1604
Query: 819 KSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE--KLQTENKK-LQLLKNAK 875
+S ++ A + +DLK + EA + A EA + KLQ + K ++ L + +
Sbjct: 1605 RSMAVAARKKLEMDLK------DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658
Query: 876 SLRSDKALDL--NTKKTTQLENE---LKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
+ R + N KK +E E L+E LA + + Q E+ E ++ K
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
L+ K+ + L +D K +I + TDL +
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTE-----LINDRLKKANLQIDQINTDLNLERSHA 1773
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ E+ ++ +K L E T K+K + I + +K+++ + + NE Q
Sbjct: 1774 QKNENARQQLERQNKELK-VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 1051 EI-------AKLKDVNAKLEGDKDVFANKYKALENENS----NLSNQCKTLTEEMKNREA 1099
KLKDV +++ D+ A +YK ++ S L Q + EE + A
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVD-DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANA 1891
Query: 1100 QINKLSADLKNATSLQTTMS 1119
KL +L++AT M+
Sbjct: 1892 SRRKLQRELEDATETADAMN 1911
Score = 81.4 bits (192), Expect = 3e-14
Identities = 191/979 (19%), Positives = 374/979 (38%), Gaps = 100/979 (10%)
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK--KLQLLKN---AKSLRSDKALDLNT 887
+K LQV QE ++ + + ++ ++L EN+ +++ L++ A+ L+ + L T
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 888 KKTTQLENELKEALAKIKELEMICQD-----EKSEKKVRFTEATKKE-TDTLKSKQXXXX 941
+ + E AK +ELE IC D E+ E++ + +A KK+ ++ +
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDD-------------AQKSFKPRIPKKPTDLTTKLQ 988
+A LK L+++ +K + RI + T+LT + +
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRL 1048
K + L+ + M ++ + + + K +E+++ R KL + ++ +++ L
Sbjct: 1014 KSKSLAKLKNKHEAMITDLE------ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 1049 QTEIAKLK--------DVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
Q +IA+LK ++ A L ++ A K AL+ + L +Q L E++++ A
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERAS 1126
Query: 1101 INKL---SADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDK 1156
NK DL + +L+T + D + ++ K +
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE-- 1184
Query: 1157 NKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLA 1216
++ + +K KR++ L K + T V+L
Sbjct: 1185 ----AQIQEMRQKHSQAVEELAEQLEQTKRVKANL--EKAKQTLENERGELANEVKVLLQ 1238
Query: 1217 ----NTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK 1272
+ H+R +E ++ ELQ +F + E L ++ L+ + +N +T L S +K
Sbjct: 1239 GKGDSEHKRKKVE--AQLQELQVKFNEGERVRTELADKVTKLQVELDN-VTGLLSQSDSK 1295
Query: 1273 DVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE 1332
+ + AL D + + E +DE N+ + +LE+ E
Sbjct: 1296 SSKLTKDFSALESQLQDTQE------LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE 1349
Query: 1333 AESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD 1392
+ ++A L + +A ++ E ++L DL+ ++ +
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA-------EEVKRKLQKDLEGLSQRHE 1402
Query: 1393 RMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
A+DK K K L L L+ + E KQ KK + LA EK
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN--LEKKQ------KKFDQLLAEEK 1454
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTES 1512
++ KY E + +AR EKE L +E E++ L ++ TE
Sbjct: 1455 T----ISAKY-AEERDRAEAEAR---EKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506
Query: 1513 AAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDX 1572
+ K ++ S+ L++ +VE + +L++ E EL+A D + LE +
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVE--EMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 1573 XXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIE-QSEKARKAEITDTKT 1631
+ K Q + + K + ++ D +
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 1632 RYEGQMNTMRDE----LKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRN 1687
+ N RDE L+ L Q+ RE D+ + + ++ +A+ K +K +
Sbjct: 1625 HID-SANKNRDEAIKQLRKLQAQMKDCMRELDDTR---ASREEILAQAKENEKKLKSMEA 1680
Query: 1688 SISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRL 1747
+ EE + A ++Q DEL + +S + EK E R+A+++ L
Sbjct: 1681 EMIQLQEELAAAERA--KRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738
Query: 1748 NEYEEERLLSSGRARVAGL 1766
E + L + R + A L
Sbjct: 1739 EEEQGNTELINDRLKKANL 1757
Score = 70.5 bits (165), Expect = 6e-11
Identities = 150/807 (18%), Positives = 338/807 (41%), Gaps = 62/807 (7%)
Query: 153 SQTQLAITKNDSLAERVRKMQL-LKTQNSFEKEPSIEKE---RERRSLSKSKED--EKTA 206
+Q +A+ K L ++ ++Q L+++ + + +K E +L ED + TA
Sbjct: 1097 AQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTA 1156
Query: 207 RYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNV 266
++ RS + +VN L + T+ + ++ V +N+
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEEAKTH-EAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 267 KEYQDQIEG----LKQEVDILR--KRCERVEKEKSDILLRRL-ANIDTANKYTTGRSSEV 319
++ + +E L EV +L K +++K + L+ L + + T + +V
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
KLQ +++ +T + LT+ +ES+L+ + Q E+ R KL + T
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ-----DTQELLQEENRQKL-SLST 1329
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+++ DE +++L + ++ A + + +++++E ++ C + ++K
Sbjct: 1330 KLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA-QVADMKKKMEDSV-GCLETAEEVK 1387
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQRELAE 498
+ +K LE HE+K V D +++ + R+++ ++ + + L +
Sbjct: 1388 RKLQK--DLEGLSQRHEEK----VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR---EQ 555
KF + + R+ + L R L++++E++A+L +Q
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
R E+ + K + + + + + + E +T +++++ +T +K +
Sbjct: 1502 FRTEMEDLMSSKD-DVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL---QATEDAKLR 1557
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
L ++ + QF DL + L + +E + E Q + MA A
Sbjct: 1558 -----LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ-RSMAVAA 1611
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
R +KL + I++AN N ++ + + ++ + E + T R+ E L Q K
Sbjct: 1612 R-KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE-EILAQAK 1669
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRS----------LTTNSNK--LAEERVKVLE 783
E KK +K + +++ + + A + R++ + +S K LA E + LE
Sbjct: 1670 ENEKK-LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE 1728
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
I ++ ++L E++ + E ++ L A + + +L+ S Q + RQ +E++
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ--LERQ 1786
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
L+ K Q +E ++++ K AK + ++ LD TK+ +++ K
Sbjct: 1787 NKELKVKLQEMEGT---VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKK 1843
Query: 904 IKELEMICQDEKSEKKVRFTEATKKET 930
+K++ + DE+ + +A K T
Sbjct: 1844 LKDVLLQVDDERRNAEQYKDQADKAST 1870
Score = 61.7 bits (143), Expect = 3e-08
Identities = 74/349 (21%), Positives = 154/349 (44%), Gaps = 24/349 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERV--EKEKSDILLRRL-ANIDTANKYTTGRSSEVLKLQ 323
K+ Q+ ++ E++ RK+ ++K ++ L+ L A+ID+ANK ++ KLQ
Sbjct: 1585 KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
++ + +D R ++ + + +E E +L+ S EA ++ QL+ +L AAE +
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLK---SMEA---EMIQLQEELAAAERAKRQ 1698
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
E +++ E+ + + R +A + L ELE+ N +++ +LKK
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEA-RIAQLEEELEEEQGNTELINDRLKKANL 1757
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQEVARSTEVAL-RLQRELA 497
+ DQ+ + + ++R+N +++E+E V + ++ L+ ++A
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 498 EANSKFTGSNPSLMKVPQP--ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE-READLRE 554
+ + + T K + L + + A+ +D D R L+
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1877
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM 603
QL AEEE ++ N ++ + D T D E +S++NK+
Sbjct: 1878 QLEEAEEE---AQRANASRRKLQRELEDATETADAMNRE--VSSLKNKL 1921
Score = 59.3 bits (137), Expect = 1e-07
Identities = 102/612 (16%), Positives = 237/612 (38%), Gaps = 46/612 (7%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAAKDVHIKQLED 1281
+L EK L+ R + + E + + L K +E IT LE + ++ ++LE
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
R+ D D + ++ E++ ++EL A ++E+ A+ + A +
Sbjct: 1049 TRRKLEGDSTDLSD---QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL---DRMRIAH 1398
+ +L+S +++L+ + + L T+L+ +R
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 1399 DKDV----KNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+++V K + E T + +++ + Q + + E ++ + LE + + E
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 1455 YEELTGKYELL-----EEEHVVTKARLTVEK--------EQAQGELLHVQKELSTALGEI 1501
EL + ++L + EH K +++ E+ + EL +L L +
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 1502 KTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAAND 1561
L + ++S+ + + +++ + QE L + + L+ +L Q E E + +
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ--KLSLSTKLKQVEDEKNSFRE 1343
Query: 1562 RRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKA 1621
+ + E D ++ + + Q +
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403
Query: 1622 RKA---EITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AAQ 1669
+ A ++ TKTR + +++ + +L +++ + Q+L A +
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 1670 KSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
+ AE + +K + + + + E + ++ L +Q ++L S+ K EL
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL 1523
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKE---RDEQQRLL 1785
K + E ++ EM+++L E E+E + + R+ M+ + ++ RDEQ
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSE-- 1581
Query: 1786 QETSTLARDLRQ 1797
++ L R +R+
Sbjct: 1582 EKKKQLVRQVRE 1593
Score = 58.0 bits (134), Expect = 3e-07
Identities = 96/526 (18%), Positives = 212/526 (40%), Gaps = 44/526 (8%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS-SEVLKLQQKV 326
Q +++ L ++D R+ +EK+ K D LL I R+ +E + + K
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELM 385
L E+ ++K L + ++ +E+E S++ + + +L A E EE+
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538
Query: 386 DENEDMKKELRD-------LXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ E+++ EL+ L M+ F D + +Q ++ R + +L
Sbjct: 1539 TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1598
Query: 439 K--KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+ + +R ++K E + K LE R+ IK+L + A+ + L
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658
Query: 497 AEANSKFTGS--NPSLMKVPQPETVKVSR----SSLTRGGSQEDPAQLLRDLQDSLEREA 550
A + N +K + E +++ + + +Q++ +L ++ +S + A
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 551 DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
E+ R E A ++ + +++ D + ++ + + + + + HA
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL-QIDQINTDLNLERSHAQKNE 1777
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE--DNESLLLQL 668
+++++ + + +E + Y + + A A++EE DNE+ Q
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK-----IAQLEEQLDNETKERQA 1832
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
+ +KL L ++ N E+ D+AD A +L L+R++
Sbjct: 1833 ACKQVRRTEKKLKDV----LLQVDDERRNAEQYKDQADKASTRL---------KQLKRQL 1879
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
EE E++ + ++L ++ T+T+ N R +++ NKL
Sbjct: 1880 EEAEEEAQRANASRRKLQRELEDATETADAMN----REVSSLKNKL 1921
Score = 55.6 bits (128), Expect = 2e-06
Identities = 125/637 (19%), Positives = 255/637 (40%), Gaps = 63/637 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR---LANIDTANKYTTGRSSE 318
V+ +++Q+E ++ L K+ + + +D+ + + ++TA + +
Sbjct: 1334 VEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKD 1393
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L Q+ E + L K L Q++ ++ +L+ + + + ++ +LLA E
Sbjct: 1394 LEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Query: 379 -TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
T+ + +E + + E R+ + E+ ++ + L R +Q L
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARAL-EEAMEQKAELERLNKQFRTEMEDLMSS 1512
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ +LE+ K E+++ E+ + +++ELE E+ + + LRL+ L
Sbjct: 1513 KDDVGKSVHELEKSKRALEQQVEEM---------KTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
++F E R S+E QL+R ++ E EA+L ++ +
Sbjct: 1564 AMKAQF-------------ERDLQGRDEQ----SEEKKKQLVRQVR---EMEAELEDERK 1603
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN--SIQNKMIHAASTPSSKEK 615
A K++ +D + + +I + + + E + +Q +M
Sbjct: 1604 QRSMAVAARKKLE----MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED---NESLLLQLKKMA 672
S L+ K E+ + + + +AA K A+ E D +E K
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE 732
R+L + +E N E D A +++ ++N + + R ++ E
Sbjct: 1720 ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQID-QINT-DLNLERSHAQKNE 1777
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
++ L++Q KEL K+ + T + + S+T K+A+ LE+++D K+
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTV---KSKYKASITALEAKIAQ-----LEEQLDNETKE 1829
Query: 793 LIEKERDCERLHAELS--LAQKKPKTLIKSRSLDASDQQNV---DLKRQLQVIEQE---A 844
+ R +L L Q + + D +D+ + LKRQL+ E+E A
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889
Query: 845 SVLRAKTQ-SLEADNEKLQTENKKLQLLKNAKSLRSD 880
+ R K Q LE E N+++ LKN K R D
Sbjct: 1890 NASRRKLQRELEDATETADAMNREVSSLKN-KLRRGD 1925
Score = 53.6 bits (123), Expect = 7e-06
Identities = 85/398 (21%), Positives = 159/398 (39%), Gaps = 36/398 (9%)
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE-----EHVVTKARLTVEKEQAQGE 1486
E+ + EE VK E LA E E T + +L+ E E + + L E E+ +
Sbjct: 846 EMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRAR 905
Query: 1487 LLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLN 1546
L ++EL +++ E+ EK +MQ +I L+E+L E E AR
Sbjct: 906 LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL----EEEESARQK 961
Query: 1547 ARLDQ--RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXX 1604
+L++ E +L+ + + +LE + ++ +
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 1605 XXXXXXXXXXIEQ---SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNY 1661
+E+ E+ ++ E+ T+ + EG + D++ L Q++ + +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 1662 KQML---------EAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVAL----LEQQV 1708
++ L EAAQK+MA K + ++I E RNK L +++
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141
Query: 1709 ACLEDELCESRLLASKLNTELVSEKSSAEVRL----AEMQSRLNEYEEERLLSSGRARVA 1764
L+ EL E L ++ EL S K EV + E +++ +E + + + V
Sbjct: 1142 EALKTEL-EDTLDSTAAQQELRS-KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 1765 GLATRMELAWHKERD---EQQRLLQETSTLARDLRQTL 1799
LA ++E + + +Q L E LA +++ L
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
>CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein.
Length = 1960
Score = 108 bits (260), Expect = 2e-22
Identities = 189/869 (21%), Positives = 365/869 (42%), Gaps = 74/869 (8%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
++++E + E +QE++ R++ E + SD + A I ++ K +
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM-------QLAKKE 1082
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
+++ E+ +K +KIRE+ES++ +E Q +E RA AE +
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKIRELESQI-----SELQ-EDLESERASRNKAEKQKRD 1136
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN--CRVLSFKLKKT 441
L +E E +K EL D Q+ R + E + L++ LE+ K ++ + K +
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQE-LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 442 ---ERKADQLEQEKA-----EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
E A+QLEQ K E K+ LE G + N +K L Q S +++
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERG----ELANEVKVLLQGKGDSEHKRKKVE 1251
Query: 494 RELAEANSKFTGSNPSLMKVPQPET-VKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+L E KF ++ T ++V ++T SQ D ++ + +D E+ L
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD-SKSSKLTKDFSALESQL 1310
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAASTP 610
++ +EE N ++++ T L + N + E E ++++ ++ +HA
Sbjct: 1311 QDTQELLQEE--NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 611 SSKEKSDSPPLSIDKTTEETQ--FHFDLPYLSIFNH---MAANNLRKTAARVEEDNESLL 665
K+ DS + +T EE + DL LS + A + L KT R++++ + LL
Sbjct: 1369 MKKKMEDS--VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
+ L A + + L+ E K +E D AE + E +A L
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTIS--AKYAEERDRAEAEA--REKETKALSLA 1482
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
R +EE + K L++ K+ +++ + + + S + E++V+ ++ +
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE--LEKSKRALEQQVEEMKTQ 1540
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
++E+ +L E RL L + + + ++ R + S+++ L RQ++ +E E
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRD-EQSEEKKKQLVRQVREMEAELE 1599
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
R + A +KL+ + K L+ ++ + D+A+ K+ +L+ ++K+ + +
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI----KQLRKLQAQMKDCM---R 1652
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
EL+ D ++ ++ +A + E LKS + Q L
Sbjct: 1653 ELD----DTRASREEILAQAKENEKK-LKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 966 DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
D+ S K L K +L+ + LE E+ E N L + K
Sbjct: 1708 DEIANSSG----KGALALEEKRRLEARIAQLEEELEEE---QGNTELINDRLK---KANL 1757
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK----ALENENS 1081
+ID+I + L+ S +N Q + K++ KL+ + +KYK ALE + +
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 1082 NLSNQCKTLTEEMKNREAQINKLSADLKN 1110
L Q T+E + Q+ + LK+
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKD 1846
Score = 93.9 bits (223), Expect = 5e-18
Identities = 214/1119 (19%), Positives = 436/1119 (38%), Gaps = 106/1119 (9%)
Query: 277 KQEVDILRKRCERVE-KEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+QE +++ K E V+ +EK RL ++T ++ + Q EL E+
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 901
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKEL 395
LR Q++ EI +LE R E E C+ L E + M++ +
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEE----------------EERCQHLQAEKKKMQQNI 945
Query: 396 RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE--KA 453
++L E+Q +E S R++L+ KLKK E + LE + K
Sbjct: 946 QEL------------EEQLEEEESARQKLQLEKVTTEA---KLKKLEEEQIILEDQNCKL 990
Query: 454 EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKV 513
EKKLL E+RI E + E + + LA+ +K L +
Sbjct: 991 AKEKKLL-----------EDRIAEFTTNLTEEEEKS----KSLAKLKNKHEAMITDLEER 1035
Query: 514 PQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPT 573
+ E + TR + D L + + + A+L+ QL EEE
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL-----A 1090
Query: 574 FLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAASTPSSKEKSD-SPPLSIDKTTEET 630
++++ N+ I E E+ + +Q + A+ + K+K D L KT E
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 631 QFHFDLPY--LSIFNHMAANNLRKTAARVEEDNESLLLQLKK---MATKARSRKLSPTPP 685
L N L+KT + +E+ + ++++ A + + +L T
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE-ELEQDKEALKKQVKE 744
K ++E A E E E E+K+LL+ + ++ R+KVE +L++ + + +
Sbjct: 1211 V-KANLEKAKQTLENERGEL-ANEVKVLLQ-GKGDSEHKRKKVEAQLQELQVKFNEGERV 1267
Query: 745 LTSKISSVTKTSAG-SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERL 803
T VTK N T S + + + + LE ++ + ++ L E+ R ++L
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR--QKL 1325
Query: 804 HAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQT 863
L Q + + L+ ++ +L++Q+ + + + ++ K + E +
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 864 ENKKLQLLKNAKSLRSDK---ALDLNTKKTTQLENELKEALAKI-KELEMICQDEKSEKK 919
+KLQ S R ++ A D K T+L+ EL + L + + + C EK +KK
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 920 VRFTEATKK--------ETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
A +K E D +++ +A L+ L +
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 972 FKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNA--GLSGKEMTAKTKLEKEIDE 1029
+ + K + +L+K LE ++ EM ++ L E AK +LE +
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE-DAKLRLEVNLQA 1564
Query: 1030 IRSKLSKN----DSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
++++ ++ D + +K +L + +++++ A+LE ++ + A + +L +
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQL---VRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Query: 1086 QCKTLTEEMKNRE---AQINKLSADLKNA-TSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ KNR+ Q+ KL A +K+ L T +
Sbjct: 1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681
Query: 1142 XXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXX 1201
+ ++ K + +E + +I + +R+E +++ ++ +
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741
Query: 1202 XXXXXXXXXQA----VVLANTHRRLSIELT-SEKDELQARFIKTESKFITLEAEMRD--L 1254
+ + + + L++E + ++K+E + ++ ++K + ++ + + +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV 1801
Query: 1255 KADYENKITSLESTIA----AKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
K+ Y+ IT+LE+ IA D K+ + A +Q + +++ + R
Sbjct: 1802 KSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861
Query: 1311 XXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
L K +LE+ E E+ A +L+ +L
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Score = 89.0 bits (211), Expect = 1e-16
Identities = 206/1075 (19%), Positives = 415/1075 (38%), Gaps = 89/1075 (8%)
Query: 538 LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LL+ + E A E ++ E++ A ++ L Q+M + + + ++ET
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+ ++ A + K++ + ++ EE + +L N+++ ++
Sbjct: 897 AEAEEL--RARLTAKKQELEEICHDLEARVEEEEERCQ--HLQAEKKKMQQNIQELEEQL 952
Query: 658 EEDNESLL-LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
EE+ + LQL+K+ T+A+ +KL ++ +E N KE + + L
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEE----EQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
E+E + + +L+ EA+ + +L ++ K T RR L +S L++
Sbjct: 1009 TEEEEK--SKSLAKLKNKHEAM---ITDLEERLRREEKQRQELEKT-RRKLEGDSTDLSD 1062
Query: 777 ERVKVLEDEIDEVRKKLIEKERDCERLHAELSL-AQKKPKTLIKSRSLDASDQQNVDLKR 835
+ + L+ +I E++ +L +KE + + A + A +K L K R L++ Q +L+
Sbjct: 1063 Q-IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES---QISELQE 1118
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTE-NKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
L+ + + + L + E L+TE L + LRS + ++N K T LE
Sbjct: 1119 DLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT-LE 1177
Query: 895 NELKEALAKIKELEMICQD------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
E K A+I+E+ E+ E+ R +K TL++++
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKP--RIPKKPTDLTTKLQLK---------------- 990
+ +++ + Q F R+ + D TKLQ++
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 991 KMVED---LECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKN 1046
K+ +D LE ++ + +++ ++ K K +E E + R +L + + N +
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 1047 RLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
++ T A++ D+ K+E + E L + L++ + + A +KL
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCL----ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE- 1412
Query: 1107 DLKNATSLQTTMSDCMXXXXXXXXXX----XXXXXXXXXXXXQVDNYTKIDQDKNKLLKE 1162
K T LQ + D + + K +++++ E
Sbjct: 1413 --KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE 1470
Query: 1163 VGDKTKK---IGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+K K + +R+ KQ T + + +
Sbjct: 1471 AREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL 1530
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
+ E+ ++ +EL+ TE + LE ++ +KA +E + + K KQL
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK---KQL 1587
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+R+ + DE V R D N + EA K
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK-----NRDEAIKQLRK 1642
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
L+ AQ+K + +L++ E K K ++ ++ +++L A
Sbjct: 1643 LQ-AQMKDCMRELDDTRASREEILAQAKEN----EKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+ + +D ELA + +SG GA + E K+ E + +LE L E+ E +
Sbjct: 1698 QAQQERD-ELA------DEIANSSGKGALALEE-KRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKT-LQEKLGTESAAWNTE 1518
+ + + L +E+ AQ + + +++L E+K LQE GT + +
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQ-KNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 1519 KTEMQNSIASLQERLCGGGWEVERARLNARLDQRERE--LRAANDRRDVLEHHHD 1571
T ++ IA L+E+L E + A R +++ + L +D R E + D
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Score = 85.4 bits (202), Expect = 2e-15
Identities = 201/980 (20%), Positives = 398/980 (40%), Gaps = 106/980 (10%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E + L K +N E + +ER RR + +E EKT R + S+ D +Q +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
LK + + ++E + QI L+++++ R
Sbjct: 1071 ----IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 287 CERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ-QKVNELTTHNEDLRDEKKHLTQ 345
+ EK+K D+ G E LK + + + T ++LR +++ Q
Sbjct: 1127 RNKAEKQKRDL----------------GEELEALKTELEDTLDSTAAQQELRSKRE---Q 1167
Query: 346 KIREIESELETRPST-EAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXX 404
++ ++ LE T EAQ +++ Q ++ A E L E+L ++ + +K L
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQ--AVEELAEQL-EQTKRVKANL--------- 1215
Query: 405 MQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG 464
+ ++ +E L E++ ++ K KK E + +L+ + E E+ E+
Sbjct: 1216 --EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD 1273
Query: 465 GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
+Q E + + +++S + +L ++ + S+ + L + K+S S
Sbjct: 1274 KVTKLQVE--LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ---EENRQKLSLS 1328
Query: 525 SLTRGGSQEDPAQLLRD-LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
T+ ED R+ L++ E + +L +Q+ + A+ K+ M D+
Sbjct: 1329 --TKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM----------KKKMEDS 1376
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
V C + +E V +Q K + S ++ + L KT + + DL
Sbjct: 1377 -VGC-LETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD-DLLVDLDHQ 1432
Query: 644 HMAANNLRKTAARVEE-DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
+A NL K + ++ E + K + R+ + LS+ A + ++
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 703 DEADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSV-TKTSAGS 759
E + + E+ + ++ + + V ELE+ K AL++QV+E+ +++ + + A
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 760 NTTARRSLTTNSNKLAEER-VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
+ R + + K ER ++ +++ +E +K+L+ + R+ E AEL +K+
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME---AELEDERKQ----- 1604
Query: 819 KSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE--KLQTENKK-LQLLKNAK 875
+S ++ A + +DLK + EA + A EA + KLQ + K ++ L + +
Sbjct: 1605 RSMAVAARKKLEMDLK------DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658
Query: 876 SLRSDKALDL--NTKKTTQLENE---LKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
+ R + N KK +E E L+E LA + + Q E+ E ++ K
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
L+ K+ + L +D K +I + TDL +
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTE-----LINDRLKKANLQIDQINTDLNLERSHA 1773
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ E+ ++ +K L E T K+K + I + +K+++ + + NE Q
Sbjct: 1774 QKNENARQQLERQNKELK-VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 1051 EI-------AKLKDVNAKLEGDKDVFANKYKALENENS----NLSNQCKTLTEEMKNREA 1099
KLKDV +++ D+ A +YK ++ S L Q + EE + A
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVD-DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANA 1891
Query: 1100 QINKLSADLKNATSLQTTMS 1119
KL +L++AT M+
Sbjct: 1892 SRRKLQRELEDATETADAMN 1911
Score = 81.4 bits (192), Expect = 3e-14
Identities = 191/979 (19%), Positives = 374/979 (38%), Gaps = 100/979 (10%)
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK--KLQLLKN---AKSLRSDKALDLNT 887
+K LQV QE ++ + + ++ ++L EN+ +++ L++ A+ L+ + L T
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 888 KKTTQLENELKEALAKIKELEMICQD-----EKSEKKVRFTEATKKE-TDTLKSKQXXXX 941
+ + E AK +ELE IC D E+ E++ + +A KK+ ++ +
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDD-------------AQKSFKPRIPKKPTDLTTKLQ 988
+A LK L+++ +K + RI + T+LT + +
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRL 1048
K + L+ + M ++ + + + K +E+++ R KL + ++ +++ L
Sbjct: 1014 KSKSLAKLKNKHEAMITDLE------ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 1049 QTEIAKLK--------DVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
Q +IA+LK ++ A L ++ A K AL+ + L +Q L E++++ A
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERAS 1126
Query: 1101 INKL---SADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDK 1156
NK DL + +L+T + D + ++ K +
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE-- 1184
Query: 1157 NKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLA 1216
++ + +K KR++ L K + T V+L
Sbjct: 1185 ----AQIQEMRQKHSQAVEELAEQLEQTKRVKANL--EKAKQTLENERGELANEVKVLLQ 1238
Query: 1217 ----NTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK 1272
+ H+R +E ++ ELQ +F + E L ++ L+ + +N +T L S +K
Sbjct: 1239 GKGDSEHKRKKVE--AQLQELQVKFNEGERVRTELADKVTKLQVELDN-VTGLLSQSDSK 1295
Query: 1273 DVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE 1332
+ + AL D + + E +DE N+ + +LE+ E
Sbjct: 1296 SSKLTKDFSALESQLQDTQE------LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE 1349
Query: 1333 AESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD 1392
+ ++A L + +A ++ E ++L DL+ ++ +
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA-------EEVKRKLQKDLEGLSQRHE 1402
Query: 1393 RMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
A+DK K K L L L+ + E KQ KK + LA EK
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN--LEKKQ------KKFDQLLAEEK 1454
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTES 1512
++ KY E + +AR EKE L +E E++ L ++ TE
Sbjct: 1455 T----ISAKY-AEERDRAEAEAR---EKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506
Query: 1513 AAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDX 1572
+ K ++ S+ L++ +VE + +L++ E EL+A D + LE +
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVE--EMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 1573 XXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIE-QSEKARKAEITDTKT 1631
+ K Q + + K + ++ D +
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 1632 RYEGQMNTMRDE----LKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRN 1687
+ N RDE L+ L Q+ RE D+ + + ++ +A+ K +K +
Sbjct: 1625 HID-SANKNRDEAIKQLRKLQAQMKDCMRELDDTR---ASREEILAQAKENEKKLKSMEA 1680
Query: 1688 SISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRL 1747
+ EE + A ++Q DEL + +S + EK E R+A+++ L
Sbjct: 1681 EMIQLQEELAAAERA--KRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738
Query: 1748 NEYEEERLLSSGRARVAGL 1766
E + L + R + A L
Sbjct: 1739 EEEQGNTELINDRLKKANL 1757
Score = 70.5 bits (165), Expect = 6e-11
Identities = 150/807 (18%), Positives = 338/807 (41%), Gaps = 62/807 (7%)
Query: 153 SQTQLAITKNDSLAERVRKMQL-LKTQNSFEKEPSIEKE---RERRSLSKSKED--EKTA 206
+Q +A+ K L ++ ++Q L+++ + + +K E +L ED + TA
Sbjct: 1097 AQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTA 1156
Query: 207 RYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNV 266
++ RS + +VN L + T+ + ++ V +N+
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEEAKTH-EAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 267 KEYQDQIEG----LKQEVDILR--KRCERVEKEKSDILLRRL-ANIDTANKYTTGRSSEV 319
++ + +E L EV +L K +++K + L+ L + + T + +V
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
KLQ +++ +T + LT+ +ES+L+ + Q E+ R KL + T
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ-----DTQELLQEENRQKL-SLST 1329
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+++ DE +++L + ++ A + + +++++E ++ C + ++K
Sbjct: 1330 KLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA-QVADMKKKMEDSV-GCLETAEEVK 1387
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQRELAE 498
+ +K LE HE+K V D +++ + R+++ ++ + + L +
Sbjct: 1388 RKLQK--DLEGLSQRHEEK----VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR---EQ 555
KF + + R+ + L R L++++E++A+L +Q
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
R E+ + K + + + + + + E +T +++++ +T +K +
Sbjct: 1502 FRTEMEDLMSSKD-DVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL---QATEDAKLR 1557
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
L ++ + QF DL + L + +E + E Q + MA A
Sbjct: 1558 -----LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ-RSMAVAA 1611
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
R +KL + I++AN N ++ + + ++ + E + T R+ E L Q K
Sbjct: 1612 R-KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE-EILAQAK 1669
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRS----------LTTNSNK--LAEERVKVLE 783
E KK +K + +++ + + A + R++ + +S K LA E + LE
Sbjct: 1670 ENEKK-LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE 1728
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
I ++ ++L E++ + E ++ L A + + +L+ S Q + RQ +E++
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ--LERQ 1786
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
L+ K Q +E ++++ K AK + ++ LD TK+ +++ K
Sbjct: 1787 NKELKVKLQEMEGT---VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKK 1843
Query: 904 IKELEMICQDEKSEKKVRFTEATKKET 930
+K++ + DE+ + +A K T
Sbjct: 1844 LKDVLLQVDDERRNAEQYKDQADKAST 1870
Score = 61.7 bits (143), Expect = 3e-08
Identities = 74/349 (21%), Positives = 154/349 (44%), Gaps = 24/349 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERV--EKEKSDILLRRL-ANIDTANKYTTGRSSEVLKLQ 323
K+ Q+ ++ E++ RK+ ++K ++ L+ L A+ID+ANK ++ KLQ
Sbjct: 1585 KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
++ + +D R ++ + + +E E +L+ S EA ++ QL+ +L AAE +
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLK---SMEA---EMIQLQEELAAAERAKRQ 1698
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
E +++ E+ + + R +A + L ELE+ N +++ +LKK
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEA-RIAQLEEELEEEQGNTELINDRLKKANL 1757
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQEVARSTEVAL-RLQRELA 497
+ DQ+ + + ++R+N +++E+E V + ++ L+ ++A
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 498 EANSKFTGSNPSLMKVPQP--ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE-READLRE 554
+ + + T K + L + + A+ +D D R L+
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1877
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM 603
QL AEEE ++ N ++ + D T D E +S++NK+
Sbjct: 1878 QLEEAEEE---AQRANASRRKLQRELEDATETADAMNRE--VSSLKNKL 1921
Score = 59.3 bits (137), Expect = 1e-07
Identities = 102/612 (16%), Positives = 237/612 (38%), Gaps = 46/612 (7%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAAKDVHIKQLED 1281
+L EK L+ R + + E + + L K +E IT LE + ++ ++LE
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
R+ D D + ++ E++ ++EL A ++E+ A+ + A +
Sbjct: 1049 TRRKLEGDSTDLSD---QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL---DRMRIAH 1398
+ +L+S +++L+ + + L T+L+ +R
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 1399 DKDV----KNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+++V K + E T + +++ + Q + + E ++ + LE + + E
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 1455 YEELTGKYELL-----EEEHVVTKARLTVEK--------EQAQGELLHVQKELSTALGEI 1501
EL + ++L + EH K +++ E+ + EL +L L +
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 1502 KTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAAND 1561
L + ++S+ + + +++ + QE L + + L+ +L Q E E + +
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ--KLSLSTKLKQVEDEKNSFRE 1343
Query: 1562 RRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKA 1621
+ + E D ++ + + Q +
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403
Query: 1622 RKA---EITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AAQ 1669
+ A ++ TKTR + +++ + +L +++ + Q+L A +
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 1670 KSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
+ AE + +K + + + + E + ++ L +Q ++L S+ K EL
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL 1523
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKE---RDEQQRLL 1785
K + E ++ EM+++L E E+E + + R+ M+ + ++ RDEQ
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSE-- 1581
Query: 1786 QETSTLARDLRQ 1797
++ L R +R+
Sbjct: 1582 EKKKQLVRQVRE 1593
Score = 58.0 bits (134), Expect = 3e-07
Identities = 96/526 (18%), Positives = 212/526 (40%), Gaps = 44/526 (8%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS-SEVLKLQQKV 326
Q +++ L ++D R+ +EK+ K D LL I R+ +E + + K
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELM 385
L E+ ++K L + ++ +E+E S++ + + +L A E EE+
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538
Query: 386 DENEDMKKELRD-------LXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ E+++ EL+ L M+ F D + +Q ++ R + +L
Sbjct: 1539 TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1598
Query: 439 K--KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+ + +R ++K E + K LE R+ IK+L + A+ + L
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658
Query: 497 AEANSKFTGS--NPSLMKVPQPETVKVSR----SSLTRGGSQEDPAQLLRDLQDSLEREA 550
A + N +K + E +++ + + +Q++ +L ++ +S + A
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 551 DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
E+ R E A ++ + +++ D + ++ + + + + + HA
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL-QIDQINTDLNLERSHAQKNE 1777
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE--DNESLLLQL 668
+++++ + + +E + Y + + A A++EE DNE+ Q
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK-----IAQLEEQLDNETKERQA 1832
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
+ +KL L ++ N E+ D+AD A +L L+R++
Sbjct: 1833 ACKQVRRTEKKLKDV----LLQVDDERRNAEQYKDQADKASTRL---------KQLKRQL 1879
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
EE E++ + ++L ++ T+T+ N R +++ NKL
Sbjct: 1880 EEAEEEAQRANASRRKLQRELEDATETADAMN----REVSSLKNKL 1921
Score = 55.6 bits (128), Expect = 2e-06
Identities = 125/637 (19%), Positives = 255/637 (40%), Gaps = 63/637 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR---LANIDTANKYTTGRSSE 318
V+ +++Q+E ++ L K+ + + +D+ + + ++TA + +
Sbjct: 1334 VEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKD 1393
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L Q+ E + L K L Q++ ++ +L+ + + + ++ +LLA E
Sbjct: 1394 LEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Query: 379 -TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
T+ + +E + + E R+ + E+ ++ + L R +Q L
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARAL-EEAMEQKAELERLNKQFRTEMEDLMSS 1512
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ +LE+ K E+++ E+ + +++ELE E+ + + LRL+ L
Sbjct: 1513 KDDVGKSVHELEKSKRALEQQVEEM---------KTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
++F E R S+E QL+R ++ E EA+L ++ +
Sbjct: 1564 AMKAQF-------------ERDLQGRDEQ----SEEKKKQLVRQVR---EMEAELEDERK 1603
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN--SIQNKMIHAASTPSSKEK 615
A K++ +D + + +I + + + E + +Q +M
Sbjct: 1604 QRSMAVAARKKLE----MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED---NESLLLQLKKMA 672
S L+ K E+ + + + +AA K A+ E D +E K
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE 732
R+L + +E N E D A +++ ++N + + R ++ E
Sbjct: 1720 ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQID-QINT-DLNLERSHAQKNE 1777
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
++ L++Q KEL K+ + T + + S+T K+A+ LE+++D K+
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTV---KSKYKASITALEAKIAQ-----LEEQLDNETKE 1829
Query: 793 LIEKERDCERLHAELS--LAQKKPKTLIKSRSLDASDQQNV---DLKRQLQVIEQE---A 844
+ R +L L Q + + D +D+ + LKRQL+ E+E A
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889
Query: 845 SVLRAKTQ-SLEADNEKLQTENKKLQLLKNAKSLRSD 880
+ R K Q LE E N+++ LKN K R D
Sbjct: 1890 NASRRKLQRELEDATETADAMNREVSSLKN-KLRRGD 1925
Score = 53.6 bits (123), Expect = 7e-06
Identities = 85/398 (21%), Positives = 159/398 (39%), Gaps = 36/398 (9%)
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE-----EHVVTKARLTVEKEQAQGE 1486
E+ + EE VK E LA E E T + +L+ E E + + L E E+ +
Sbjct: 846 EMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRAR 905
Query: 1487 LLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLN 1546
L ++EL +++ E+ EK +MQ +I L+E+L E E AR
Sbjct: 906 LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL----EEEESARQK 961
Query: 1547 ARLDQ--RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXX 1604
+L++ E +L+ + + +LE + ++ +
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 1605 XXXXXXXXXXIEQ---SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNY 1661
+E+ E+ ++ E+ T+ + EG + D++ L Q++ + +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 1662 KQML---------EAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVAL----LEQQV 1708
++ L EAAQK+MA K + ++I E RNK L +++
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141
Query: 1709 ACLEDELCESRLLASKLNTELVSEKSSAEVRL----AEMQSRLNEYEEERLLSSGRARVA 1764
L+ EL E L ++ EL S K EV + E +++ +E + + + V
Sbjct: 1142 EALKTEL-EDTLDSTAAQQELRS-KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 1765 GLATRMELAWHKERD---EQQRLLQETSTLARDLRQTL 1799
LA ++E + + +Q L E LA +++ L
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
>AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy
polypeptide 9 protein.
Length = 1960
Score = 108 bits (260), Expect = 2e-22
Identities = 189/869 (21%), Positives = 365/869 (42%), Gaps = 74/869 (8%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
++++E + E +QE++ R++ E + SD + A I ++ K +
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM-------QLAKKE 1082
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
+++ E+ +K +KIRE+ES++ +E Q +E RA AE +
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKIRELESQI-----SELQ-EDLESERASRNKAEKQKRD 1136
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN--CRVLSFKLKKT 441
L +E E +K EL D Q+ R + E + L++ LE+ K ++ + K +
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQE-LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 442 ---ERKADQLEQEKA-----EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
E A+QLEQ K E K+ LE G + N +K L Q S +++
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERG----ELANEVKVLLQGKGDSEHKRKKVE 1251
Query: 494 RELAEANSKFTGSNPSLMKVPQPET-VKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+L E KF ++ T ++V ++T SQ D ++ + +D E+ L
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD-SKSSKLTKDFSALESQL 1310
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAASTP 610
++ +EE N ++++ T L + N + E E ++++ ++ +HA
Sbjct: 1311 QDTQELLQEE--NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 611 SSKEKSDSPPLSIDKTTEETQ--FHFDLPYLSIFNH---MAANNLRKTAARVEEDNESLL 665
K+ DS + +T EE + DL LS + A + L KT R++++ + LL
Sbjct: 1369 MKKKMEDS--VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
+ L A + + L+ E K +E D AE + E +A L
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTIS--AKYAEERDRAEAEA--REKETKALSLA 1482
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
R +EE + K L++ K+ +++ + + + S + E++V+ ++ +
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE--LEKSKRALEQQVEEMKTQ 1540
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
++E+ +L E RL L + + + ++ R + S+++ L RQ++ +E E
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRD-EQSEEKKKQLVRQVREMEAELE 1599
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
R + A +KL+ + K L+ ++ + D+A+ K+ +L+ ++K+ + +
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI----KQLRKLQAQMKDCM---R 1652
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
EL+ D ++ ++ +A + E LKS + Q L
Sbjct: 1653 ELD----DTRASREEILAQAKENEKK-LKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 966 DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
D+ S K L K +L+ + LE E+ E N L + K
Sbjct: 1708 DEIANSSG----KGALALEEKRRLEARIAQLEEELEEE---QGNTELINDRLK---KANL 1757
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK----ALENENS 1081
+ID+I + L+ S +N Q + K++ KL+ + +KYK ALE + +
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 1082 NLSNQCKTLTEEMKNREAQINKLSADLKN 1110
L Q T+E + Q+ + LK+
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKD 1846
Score = 93.9 bits (223), Expect = 5e-18
Identities = 214/1119 (19%), Positives = 436/1119 (38%), Gaps = 106/1119 (9%)
Query: 277 KQEVDILRKRCERVE-KEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+QE +++ K E V+ +EK RL ++T ++ + Q EL E+
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 901
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKEL 395
LR Q++ EI +LE R E E C+ L E + M++ +
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEE----------------EERCQHLQAEKKKMQQNI 945
Query: 396 RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE--KA 453
++L E+Q +E S R++L+ KLKK E + LE + K
Sbjct: 946 QEL------------EEQLEEEESARQKLQLEKVTTEA---KLKKLEEEQIILEDQNCKL 990
Query: 454 EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKV 513
EKKLL E+RI E + E + + LA+ +K L +
Sbjct: 991 AKEKKLL-----------EDRIAEFTTNLTEEEEKS----KSLAKLKNKHEAMITDLEER 1035
Query: 514 PQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPT 573
+ E + TR + D L + + + A+L+ QL EEE
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL-----A 1090
Query: 574 FLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAASTPSSKEKSD-SPPLSIDKTTEET 630
++++ N+ I E E+ + +Q + A+ + K+K D L KT E
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 631 QFHFDLPY--LSIFNHMAANNLRKTAARVEEDNESLLLQLKK---MATKARSRKLSPTPP 685
L N L+KT + +E+ + ++++ A + + +L T
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE-ELEQDKEALKKQVKE 744
K ++E A E E E E+K+LL+ + ++ R+KVE +L++ + + +
Sbjct: 1211 V-KANLEKAKQTLENERGEL-ANEVKVLLQ-GKGDSEHKRKKVEAQLQELQVKFNEGERV 1267
Query: 745 LTSKISSVTKTSAG-SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERL 803
T VTK N T S + + + + LE ++ + ++ L E+ R ++L
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR--QKL 1325
Query: 804 HAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQT 863
L Q + + L+ ++ +L++Q+ + + + ++ K + E +
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 864 ENKKLQLLKNAKSLRSDK---ALDLNTKKTTQLENELKEALAKI-KELEMICQDEKSEKK 919
+KLQ S R ++ A D K T+L+ EL + L + + + C EK +KK
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 920 VRFTEATKK--------ETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
A +K E D +++ +A L+ L +
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 972 FKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNA--GLSGKEMTAKTKLEKEIDE 1029
+ + K + +L+K LE ++ EM ++ L E AK +LE +
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE-DAKLRLEVNLQA 1564
Query: 1030 IRSKLSKN----DSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
++++ ++ D + +K +L + +++++ A+LE ++ + A + +L +
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQL---VRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Query: 1086 QCKTLTEEMKNRE---AQINKLSADLKNA-TSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ KNR+ Q+ KL A +K+ L T +
Sbjct: 1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681
Query: 1142 XXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXX 1201
+ ++ K + +E + +I + +R+E +++ ++ +
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741
Query: 1202 XXXXXXXXXQA----VVLANTHRRLSIELT-SEKDELQARFIKTESKFITLEAEMRD--L 1254
+ + + + L++E + ++K+E + ++ ++K + ++ + + +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV 1801
Query: 1255 KADYENKITSLESTIA----AKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
K+ Y+ IT+LE+ IA D K+ + A +Q + +++ + R
Sbjct: 1802 KSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY 1861
Query: 1311 XXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
L K +LE+ E E+ A +L+ +L
Sbjct: 1862 KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Score = 89.0 bits (211), Expect = 1e-16
Identities = 206/1075 (19%), Positives = 415/1075 (38%), Gaps = 89/1075 (8%)
Query: 538 LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LL+ + E A E ++ E++ A ++ L Q+M + + + ++ET
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+ ++ A + K++ + ++ EE + +L N+++ ++
Sbjct: 897 AEAEEL--RARLTAKKQELEEICHDLEARVEEEEERCQ--HLQAEKKKMQQNIQELEEQL 952
Query: 658 EEDNESLL-LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
EE+ + LQL+K+ T+A+ +KL ++ +E N KE + + L
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEE----EQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
E+E + + +L+ EA+ + +L ++ K T RR L +S L++
Sbjct: 1009 TEEEEK--SKSLAKLKNKHEAM---ITDLEERLRREEKQRQELEKT-RRKLEGDSTDLSD 1062
Query: 777 ERVKVLEDEIDEVRKKLIEKERDCERLHAELSL-AQKKPKTLIKSRSLDASDQQNVDLKR 835
+ + L+ +I E++ +L +KE + + A + A +K L K R L++ Q +L+
Sbjct: 1063 Q-IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES---QISELQE 1118
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTE-NKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
L+ + + + L + E L+TE L + LRS + ++N K T LE
Sbjct: 1119 DLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT-LE 1177
Query: 895 NELKEALAKIKELEMICQD------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
E K A+I+E+ E+ E+ R +K TL++++
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKP--RIPKKPTDLTTKLQLK---------------- 990
+ +++ + Q F R+ + D TKLQ++
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 991 KMVED---LECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKN 1046
K+ +D LE ++ + +++ ++ K K +E E + R +L + + N +
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 1047 RLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
++ T A++ D+ K+E + E L + L++ + + A +KL
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCL----ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE- 1412
Query: 1107 DLKNATSLQTTMSDCMXXXXXXXXXX----XXXXXXXXXXXXQVDNYTKIDQDKNKLLKE 1162
K T LQ + D + + K +++++ E
Sbjct: 1413 --KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE 1470
Query: 1163 VGDKTKK---IGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+K K + +R+ KQ T + + +
Sbjct: 1471 AREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL 1530
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
+ E+ ++ +EL+ TE + LE ++ +KA +E + + K KQL
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK---KQL 1587
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+R+ + DE V R D N + EA K
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK-----NRDEAIKQLRK 1642
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
L+ AQ+K + +L++ E K K ++ ++ +++L A
Sbjct: 1643 LQ-AQMKDCMRELDDTRASREEILAQAKEN----EKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+ + +D ELA + +SG GA + E K+ E + +LE L E+ E +
Sbjct: 1698 QAQQERD-ELA------DEIANSSGKGALALEE-KRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKT-LQEKLGTESAAWNTE 1518
+ + + L +E+ AQ + + +++L E+K LQE GT + +
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQ-KNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 1519 KTEMQNSIASLQERLCGGGWEVERARLNARLDQRERE--LRAANDRRDVLEHHHD 1571
T ++ IA L+E+L E + A R +++ + L +D R E + D
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Score = 85.4 bits (202), Expect = 2e-15
Identities = 201/980 (20%), Positives = 398/980 (40%), Gaps = 106/980 (10%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E + L K +N E + +ER RR + +E EKT R + S+ D +Q +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
LK + + ++E + QI L+++++ R
Sbjct: 1071 ----IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 287 CERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ-QKVNELTTHNEDLRDEKKHLTQ 345
+ EK+K D+ G E LK + + + T ++LR +++ Q
Sbjct: 1127 RNKAEKQKRDL----------------GEELEALKTELEDTLDSTAAQQELRSKRE---Q 1167
Query: 346 KIREIESELETRPST-EAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXX 404
++ ++ LE T EAQ +++ Q ++ A E L E+L ++ + +K L
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQ--AVEELAEQL-EQTKRVKANL--------- 1215
Query: 405 MQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG 464
+ ++ +E L E++ ++ K KK E + +L+ + E E+ E+
Sbjct: 1216 --EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD 1273
Query: 465 GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
+Q E + + +++S + +L ++ + S+ + L + K+S S
Sbjct: 1274 KVTKLQVE--LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ---EENRQKLSLS 1328
Query: 525 SLTRGGSQEDPAQLLRD-LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
T+ ED R+ L++ E + +L +Q+ + A+ K+ M D+
Sbjct: 1329 --TKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM----------KKKMEDS 1376
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
V C + +E V +Q K + S ++ + L KT + + DL
Sbjct: 1377 -VGC-LETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD-DLLVDLDHQ 1432
Query: 644 HMAANNLRKTAARVEE-DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
+A NL K + ++ E + K + R+ + LS+ A + ++
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 703 DEADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSV-TKTSAGS 759
E + + E+ + ++ + + V ELE+ K AL++QV+E+ +++ + + A
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 760 NTTARRSLTTNSNKLAEER-VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
+ R + + K ER ++ +++ +E +K+L+ + R+ E AEL +K+
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME---AELEDERKQ----- 1604
Query: 819 KSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE--KLQTENKK-LQLLKNAK 875
+S ++ A + +DLK + EA + A EA + KLQ + K ++ L + +
Sbjct: 1605 RSMAVAARKKLEMDLK------DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658
Query: 876 SLRSDKALDL--NTKKTTQLENE---LKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
+ R + N KK +E E L+E LA + + Q E+ E ++ K
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
L+ K+ + L +D K +I + TDL +
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTE-----LINDRLKKANLQIDQINTDLNLERSHA 1773
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ E+ ++ +K L E T K+K + I + +K+++ + + NE Q
Sbjct: 1774 QKNENARQQLERQNKELK-VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 1051 EI-------AKLKDVNAKLEGDKDVFANKYKALENENS----NLSNQCKTLTEEMKNREA 1099
KLKDV +++ D+ A +YK ++ S L Q + EE + A
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVD-DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANA 1891
Query: 1100 QINKLSADLKNATSLQTTMS 1119
KL +L++AT M+
Sbjct: 1892 SRRKLQRELEDATETADAMN 1911
Score = 81.4 bits (192), Expect = 3e-14
Identities = 191/979 (19%), Positives = 374/979 (38%), Gaps = 100/979 (10%)
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK--KLQLLKN---AKSLRSDKALDLNT 887
+K LQV QE ++ + + ++ ++L EN+ +++ L++ A+ L+ + L T
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 888 KKTTQLENELKEALAKIKELEMICQD-----EKSEKKVRFTEATKKE-TDTLKSKQXXXX 941
+ + E AK +ELE IC D E+ E++ + +A KK+ ++ +
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDD-------------AQKSFKPRIPKKPTDLTTKLQ 988
+A LK L+++ +K + RI + T+LT + +
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRL 1048
K + L+ + M ++ + + + K +E+++ R KL + ++ +++ L
Sbjct: 1014 KSKSLAKLKNKHEAMITDLE------ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 1049 QTEIAKLK--------DVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
Q +IA+LK ++ A L ++ A K AL+ + L +Q L E++++ A
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERAS 1126
Query: 1101 INKL---SADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDK 1156
NK DL + +L+T + D + ++ K +
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE-- 1184
Query: 1157 NKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLA 1216
++ + +K KR++ L K + T V+L
Sbjct: 1185 ----AQIQEMRQKHSQAVEELAEQLEQTKRVKANL--EKAKQTLENERGELANEVKVLLQ 1238
Query: 1217 ----NTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK 1272
+ H+R +E ++ ELQ +F + E L ++ L+ + +N +T L S +K
Sbjct: 1239 GKGDSEHKRKKVE--AQLQELQVKFNEGERVRTELADKVTKLQVELDN-VTGLLSQSDSK 1295
Query: 1273 DVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE 1332
+ + AL D + + E +DE N+ + +LE+ E
Sbjct: 1296 SSKLTKDFSALESQLQDTQE------LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE 1349
Query: 1333 AESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD 1392
+ ++A L + +A ++ E ++L DL+ ++ +
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA-------EEVKRKLQKDLEGLSQRHE 1402
Query: 1393 RMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
A+DK K K L L L+ + E KQ KK + LA EK
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN--LEKKQ------KKFDQLLAEEK 1454
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTES 1512
++ KY E + +AR EKE L +E E++ L ++ TE
Sbjct: 1455 T----ISAKY-AEERDRAEAEAR---EKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506
Query: 1513 AAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDX 1572
+ K ++ S+ L++ +VE + +L++ E EL+A D + LE +
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVE--EMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 1573 XXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIE-QSEKARKAEITDTKT 1631
+ K Q + + K + ++ D +
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 1632 RYEGQMNTMRDE----LKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRN 1687
+ N RDE L+ L Q+ RE D+ + + ++ +A+ K +K +
Sbjct: 1625 HID-SANKNRDEAIKQLRKLQAQMKDCMRELDDTR---ASREEILAQAKENEKKLKSMEA 1680
Query: 1688 SISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRL 1747
+ EE + A ++Q DEL + +S + EK E R+A+++ L
Sbjct: 1681 EMIQLQEELAAAERA--KRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738
Query: 1748 NEYEEERLLSSGRARVAGL 1766
E + L + R + A L
Sbjct: 1739 EEEQGNTELINDRLKKANL 1757
Score = 70.5 bits (165), Expect = 6e-11
Identities = 150/807 (18%), Positives = 338/807 (41%), Gaps = 62/807 (7%)
Query: 153 SQTQLAITKNDSLAERVRKMQL-LKTQNSFEKEPSIEKE---RERRSLSKSKED--EKTA 206
+Q +A+ K L ++ ++Q L+++ + + +K E +L ED + TA
Sbjct: 1097 AQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTA 1156
Query: 207 RYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNV 266
++ RS + +VN L + T+ + ++ V +N+
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEEAKTH-EAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 267 KEYQDQIEG----LKQEVDILR--KRCERVEKEKSDILLRRL-ANIDTANKYTTGRSSEV 319
++ + +E L EV +L K +++K + L+ L + + T + +V
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
KLQ +++ +T + LT+ +ES+L+ + Q E+ R KL + T
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ-----DTQELLQEENRQKL-SLST 1329
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+++ DE +++L + ++ A + + +++++E ++ C + ++K
Sbjct: 1330 KLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA-QVADMKKKMEDSV-GCLETAEEVK 1387
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQRELAE 498
+ +K LE HE+K V D +++ + R+++ ++ + + L +
Sbjct: 1388 RKLQK--DLEGLSQRHEEK----VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR---EQ 555
KF + + R+ + L R L++++E++A+L +Q
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
R E+ + K + + + + + + E +T +++++ +T +K +
Sbjct: 1502 FRTEMEDLMSSKD-DVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL---QATEDAKLR 1557
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
L ++ + QF DL + L + +E + E Q + MA A
Sbjct: 1558 -----LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ-RSMAVAA 1611
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
R +KL + I++AN N ++ + + ++ + E + T R+ E L Q K
Sbjct: 1612 R-KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE-EILAQAK 1669
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRS----------LTTNSNK--LAEERVKVLE 783
E KK +K + +++ + + A + R++ + +S K LA E + LE
Sbjct: 1670 ENEKK-LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE 1728
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
I ++ ++L E++ + E ++ L A + + +L+ S Q + RQ +E++
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ--LERQ 1786
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
L+ K Q +E ++++ K AK + ++ LD TK+ +++ K
Sbjct: 1787 NKELKVKLQEMEGT---VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKK 1843
Query: 904 IKELEMICQDEKSEKKVRFTEATKKET 930
+K++ + DE+ + +A K T
Sbjct: 1844 LKDVLLQVDDERRNAEQYKDQADKAST 1870
Score = 61.7 bits (143), Expect = 3e-08
Identities = 74/349 (21%), Positives = 154/349 (44%), Gaps = 24/349 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERV--EKEKSDILLRRL-ANIDTANKYTTGRSSEVLKLQ 323
K+ Q+ ++ E++ RK+ ++K ++ L+ L A+ID+ANK ++ KLQ
Sbjct: 1585 KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
++ + +D R ++ + + +E E +L+ S EA ++ QL+ +L AAE +
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLK---SMEA---EMIQLQEELAAAERAKRQ 1698
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
E +++ E+ + + R +A + L ELE+ N +++ +LKK
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEA-RIAQLEEELEEEQGNTELINDRLKKANL 1757
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQEVARSTEVAL-RLQRELA 497
+ DQ+ + + ++R+N +++E+E V + ++ L+ ++A
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 498 EANSKFTGSNPSLMKVPQP--ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE-READLRE 554
+ + + T K + L + + A+ +D D R L+
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1877
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM 603
QL AEEE ++ N ++ + D T D E +S++NK+
Sbjct: 1878 QLEEAEEE---AQRANASRRKLQRELEDATETADAMNRE--VSSLKNKL 1921
Score = 59.3 bits (137), Expect = 1e-07
Identities = 102/612 (16%), Positives = 237/612 (38%), Gaps = 46/612 (7%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAAKDVHIKQLED 1281
+L EK L+ R + + E + + L K +E IT LE + ++ ++LE
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
R+ D D + ++ E++ ++EL A ++E+ A+ + A +
Sbjct: 1049 TRRKLEGDSTDLSD---QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL---DRMRIAH 1398
+ +L+S +++L+ + + L T+L+ +R
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 1399 DKDV----KNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+++V K + E T + +++ + Q + + E ++ + LE + + E
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 1455 YEELTGKYELL-----EEEHVVTKARLTVEK--------EQAQGELLHVQKELSTALGEI 1501
EL + ++L + EH K +++ E+ + EL +L L +
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 1502 KTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAAND 1561
L + ++S+ + + +++ + QE L + + L+ +L Q E E + +
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ--KLSLSTKLKQVEDEKNSFRE 1343
Query: 1562 RRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKA 1621
+ + E D ++ + + Q +
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403
Query: 1622 RKA---EITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AAQ 1669
+ A ++ TKTR + +++ + +L +++ + Q+L A +
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 1670 KSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
+ AE + +K + + + + E + ++ L +Q ++L S+ K EL
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL 1523
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKE---RDEQQRLL 1785
K + E ++ EM+++L E E+E + + R+ M+ + ++ RDEQ
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSE-- 1581
Query: 1786 QETSTLARDLRQ 1797
++ L R +R+
Sbjct: 1582 EKKKQLVRQVRE 1593
Score = 58.0 bits (134), Expect = 3e-07
Identities = 96/526 (18%), Positives = 212/526 (40%), Gaps = 44/526 (8%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS-SEVLKLQQKV 326
Q +++ L ++D R+ +EK+ K D LL I R+ +E + + K
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELM 385
L E+ ++K L + ++ +E+E S++ + + +L A E EE+
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538
Query: 386 DENEDMKKELRD-------LXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ E+++ EL+ L M+ F D + +Q ++ R + +L
Sbjct: 1539 TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1598
Query: 439 K--KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+ + +R ++K E + K LE R+ IK+L + A+ + L
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 1658
Query: 497 AEANSKFTGS--NPSLMKVPQPETVKVSR----SSLTRGGSQEDPAQLLRDLQDSLEREA 550
A + N +K + E +++ + + +Q++ +L ++ +S + A
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 551 DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
E+ R E A ++ + +++ D + ++ + + + + + HA
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL-QIDQINTDLNLERSHAQKNE 1777
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE--DNESLLLQL 668
+++++ + + +E + Y + + A A++EE DNE+ Q
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK-----IAQLEEQLDNETKERQA 1832
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
+ +KL L ++ N E+ D+AD A +L L+R++
Sbjct: 1833 ACKQVRRTEKKLKDV----LLQVDDERRNAEQYKDQADKASTRL---------KQLKRQL 1879
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
EE E++ + ++L ++ T+T+ N R +++ NKL
Sbjct: 1880 EEAEEEAQRANASRRKLQRELEDATETADAMN----REVSSLKNKL 1921
Score = 55.6 bits (128), Expect = 2e-06
Identities = 125/637 (19%), Positives = 255/637 (40%), Gaps = 63/637 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR---LANIDTANKYTTGRSSE 318
V+ +++Q+E ++ L K+ + + +D+ + + ++TA + +
Sbjct: 1334 VEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKD 1393
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L Q+ E + L K L Q++ ++ +L+ + + + ++ +LLA E
Sbjct: 1394 LEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Query: 379 -TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
T+ + +E + + E R+ + E+ ++ + L R +Q L
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARAL-EEAMEQKAELERLNKQFRTEMEDLMSS 1512
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ +LE+ K E+++ E+ + +++ELE E+ + + LRL+ L
Sbjct: 1513 KDDVGKSVHELEKSKRALEQQVEEM---------KTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
++F E R S+E QL+R ++ E EA+L ++ +
Sbjct: 1564 AMKAQF-------------ERDLQGRDEQ----SEEKKKQLVRQVR---EMEAELEDERK 1603
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN--SIQNKMIHAASTPSSKEK 615
A K++ +D + + +I + + + E + +Q +M
Sbjct: 1604 QRSMAVAARKKLE----MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED---NESLLLQLKKMA 672
S L+ K E+ + + + +AA K A+ E D +E K
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE 732
R+L + +E N E D A +++ ++N + + R ++ E
Sbjct: 1720 ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQID-QINT-DLNLERSHAQKNE 1777
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
++ L++Q KEL K+ + T + + S+T K+A+ LE+++D K+
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTV---KSKYKASITALEAKIAQ-----LEEQLDNETKE 1829
Query: 793 LIEKERDCERLHAELS--LAQKKPKTLIKSRSLDASDQQNV---DLKRQLQVIEQE---A 844
+ R +L L Q + + D +D+ + LKRQL+ E+E A
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889
Query: 845 SVLRAKTQ-SLEADNEKLQTENKKLQLLKNAKSLRSD 880
+ R K Q LE E N+++ LKN K R D
Sbjct: 1890 NASRRKLQRELEDATETADAMNREVSSLKN-KLRRGD 1925
Score = 53.6 bits (123), Expect = 7e-06
Identities = 85/398 (21%), Positives = 159/398 (39%), Gaps = 36/398 (9%)
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE-----EHVVTKARLTVEKEQAQGE 1486
E+ + EE VK E LA E E T + +L+ E E + + L E E+ +
Sbjct: 846 EMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRAR 905
Query: 1487 LLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLN 1546
L ++EL +++ E+ EK +MQ +I L+E+L E E AR
Sbjct: 906 LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL----EEEESARQK 961
Query: 1547 ARLDQ--RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXX 1604
+L++ E +L+ + + +LE + ++ +
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 1605 XXXXXXXXXXIEQ---SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNY 1661
+E+ E+ ++ E+ T+ + EG + D++ L Q++ + +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 1662 KQML---------EAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVAL----LEQQV 1708
++ L EAAQK+MA K + ++I E RNK L +++
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141
Query: 1709 ACLEDELCESRLLASKLNTELVSEKSSAEVRL----AEMQSRLNEYEEERLLSSGRARVA 1764
L+ EL E L ++ EL S K EV + E +++ +E + + + V
Sbjct: 1142 EALKTEL-EDTLDSTAAQQELRS-KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 1765 GLATRMELAWHKERD---EQQRLLQETSTLARDLRQTL 1799
LA ++E + + +Q L E LA +++ L
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
>Z20656-1|CAA79675.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 105 bits (253), Expect = 1e-21
Identities = 214/1025 (20%), Positives = 389/1025 (37%), Gaps = 100/1025 (9%)
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
K K L+KS ++++ +K + I++ A+ + LE L E LQL
Sbjct: 837 KIKPLLKSAE---TEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQV 893
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
A+ D D + ++N++ + AK+KE+ +DE+ E T +K D
Sbjct: 894 QAEQ---DNLNDAEERCDQLIKNKI-QLEAKVKEMNERLEDEE-EMNAELTAKKRKLEDE 948
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ--KSFKPRIPKKPTDLTTKLQLK 990
+ + +K+L ++ ++ K+ L Q
Sbjct: 949 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ-- 1006
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ ++DL+ E ++ + K+ K KLE+++D++ L + +K R+
Sbjct: 1007 QALDDLQVEEDKVNSLSKS----------KVKLEQQVDDLEGSLEQE------KKVRMDL 1050
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
E AK KLEGD + LEN+ L E++K +E IN+ ++ +++
Sbjct: 1051 ERAK-----RKLEGDLKLTQESIMDLENDKLQLE-------EKLKKKEFDINQQNSKIED 1098
Query: 1111 ATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
+L + + +V+ K+ D ++ L+E+ ++ ++
Sbjct: 1099 EQALALQLQKKLKENQARIEELEEELEAERTARAKVE---KLRSDLSRELEEISERLEEA 1155
Query: 1171 GDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK 1230
G KR + R+D A L H EL +
Sbjct: 1156 GGATSVQIEMNK--KREAEFQKMRRD----LEEATLQHEATAAALRKKHADSVAELGEQI 1209
Query: 1231 DELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK 1290
D LQ + + K LE E + K + ++ +++E I AK LE R T D+
Sbjct: 1210 DNLQ----RVKQK---LEKEKSEFKLELDDVTSNMEQIIKAK----ANLEKVSR-TLEDQ 1257
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA---ESSAAKLEMAQLKS 1347
+E V++ E + Q E +LE+ EA + + KL Q
Sbjct: 1258 ANEYR--VKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQME 1315
Query: 1348 DLAK-LENXXXXXXXXXXXXXXX--------SSYWEN-KAK-ELDTDLQSERKKLDRMRI 1396
DL + LE Y E +AK EL L ++ + R
Sbjct: 1316 DLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1375
Query: 1397 AHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
++ D + EL K KL Q++ + + E+T +L++ + + E
Sbjct: 1376 KYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1435
Query: 1457 ELTGKYELLEEEHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKLGT 1510
L+++ L K E++Q EL QKE LST L ++K E+
Sbjct: 1436 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1495
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRDV-LEH 1568
+ E +Q I+ L E+L GG V E ++ +L+ + EL++A + + LEH
Sbjct: 1496 HLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEH 1555
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITD 1628
+ ER + +E + E+
Sbjct: 1556 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR 1615
Query: 1629 TKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI--KNGDKSARI-- 1684
K + EG +N M +L + + +++ + + +L+ Q + + N D I
Sbjct: 1616 VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675
Query: 1685 --HRNSISSTDEEEYRNKVALLEQQVACLEDELCES----RLLASKLNTELVSEKSSAEV 1738
RN++ + EE R V E+ E EL E+ +LL S+ NT L+++K E
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ-NTSLINQKKKMES 1734
Query: 1739 RLAEMQSRLNEYEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLLQETSTLARD 1794
L ++QS + E +E + +A+ A A M KE+D +R+ + +D
Sbjct: 1735 DLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 1794
Query: 1795 LRQTL 1799
L+ L
Sbjct: 1795 LQHRL 1799
Score = 105 bits (251), Expect = 2e-21
Identities = 190/968 (19%), Positives = 383/968 (39%), Gaps = 85/968 (8%)
Query: 179 NSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTN----L 234
NS K ++ E++ L S E EK R ER+ K + + + ++ + N L
Sbjct: 1020 NSLSKS-KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQL 1078
Query: 235 KPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEK 294
+ ++ + +KE Q +IE L++E++ R +VEK +
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLR 1138
Query: 295 SDILLRRLANIDTANKYTTGRSSEVLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESE 353
SD L R L I + G +S +++ +K E DL E+ L +
Sbjct: 1139 SD-LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL--EEATLQHEATAAALR 1195
Query: 354 LETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--E 411
+ S QI+ L+ E E E +D+ + + ++ R E
Sbjct: 1196 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLE 1255
Query: 412 DQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG--M 469
DQA+EY R +LE+ ++ + + K + + +L ++ E E + ++ G
Sbjct: 1256 DQANEY---RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQ 1312
Query: 470 QRENRIKELEQEVARSTEVALRLQRE------LAEANSKFTGSNPSLMKVPQPETVKVSR 523
Q E+ ++LE+E +A LQ L E + T + L +V +V++
Sbjct: 1313 QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1372
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEET-ANCKQVNPPTFLDKQVMTD 582
R + D Q +L+++ ++ A + A E A C + + + D
Sbjct: 1373 ---WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFD 635
+V D+ S ++ K + + K+K + ++ + +E + F
Sbjct: 1430 LMV--DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487
Query: 636 LPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETA 694
Y H+ ++ ++E+ L QL + K+ KL +++A
Sbjct: 1488 NAYEESLEHL--ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
+ E + + ++ LE N+ +A + RK+ E +++ E K+ + + + +
Sbjct: 1546 LEEAEASLEHEEGKILRAQLEFNQIKAEI-ERKLAEKDEEMEQAKRNHQRVVDSL----Q 1600
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
TS + T +R + K+ E +++E+ +L R+ AE K
Sbjct: 1601 TSLDAETRSRNEVLRVKKKM--------EGDLNEMEIQLSH----ANRMAAEAQKQVKSL 1648
Query: 815 KTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ-----TENKK 867
++L+K + D + N DLK + ++E+ ++L+A+ + L A E+ + E +
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL 1708
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
++ + + L S +N KK ++E++L + ++++E C++ + + K T+A
Sbjct: 1709 IETSERVQLLHSQNTSLINQKK--KMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAM 1766
Query: 928 KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL 987
+ LK +Q Q L + A K K ++ K
Sbjct: 1767 M-AEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK--------- 1816
Query: 988 QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR 1047
L+ V +LE GE+ K S K M + KE+ + KN + ++
Sbjct: 1817 -LEARVRELE---GELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDK 1872
Query: 1048 LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
LQ ++ K + E + +K++ +++E E E+Q+NKL A
Sbjct: 1873 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAE-------ERADIAESQVNKLRAK 1925
Query: 1108 LKNATSLQ 1115
++ + Q
Sbjct: 1926 SRDIGAKQ 1933
Score = 72.5 bits (170), Expect = 1e-11
Identities = 181/1033 (17%), Positives = 401/1033 (38%), Gaps = 89/1033 (8%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
++++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 861 IKETLEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ- 916
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 917 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----KDIDDLELTLAKVEKEK 970
Query: 662 ESLLLQLKKMATKARS-----RKLSPTPPANKLSIETANDNDEKETDEADP---AEMKLL 713
+ ++K + + KL+ A + + + A D+ + E D+ + +++KL
Sbjct: 971 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLE 1030
Query: 714 LELNEQEATVLR-RKVE-ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS---LT 768
++++ E ++ + +KV +LE+ K L+ +K I + ++ +
Sbjct: 1031 QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDIN 1090
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
++K+ +E+ L+ ++KKL E + E L EL + + K RS
Sbjct: 1091 QQNSKIEDEQALALQ-----LQKKLKENQARIEELEEELEAERTARAKVEKLRS------ 1139
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
DL R+L+ I + T N+K + E +K++ +L+ + K
Sbjct: 1140 ---DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1196
Query: 889 KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
K EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1197 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLED 1256
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
+ +SL D + + ++ + +L +L+ K+ + + G++ +
Sbjct: 1257 QANEYRVKLEEAQRSLNDFTTQ--RAKLQTENGELARQLEEKEALIS-QLTRGKLSYTQQ 1313
Query: 1009 NAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKD 1067
L +++ + K + + +++D + E+ +TE A+L+ V +K +
Sbjct: 1314 MEDLK-RQLEEEGKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371
Query: 1068 VFANKYKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCM 1122
+ KY+ L K L + +++ E + ++A K LQ + D M
Sbjct: 1372 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431
Query: 1123 XXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKL---LKEVGDKTKKIGDXXXXXX 1178
+ + K ++ +++L KE + ++
Sbjct: 1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1491
Query: 1179 XXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQA 1235
+ +++ ++ ++ L ++L +E L S +E +A
Sbjct: 1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEA 1551
Query: 1236 RFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEAT 1295
E K + + E +KA+ E K+ + + + +++ D+L QT+ D +
Sbjct: 1552 SLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSL-QTSLDAETRSR 1610
Query: 1296 SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENX 1355
+ V V+ + + +LN +I+L ++ A+ ++ L+S L +
Sbjct: 1611 NEVLRVKKK------------MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Query: 1356 XXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGK 1415
+ E + L +L+ R +++ ++ K + EL +
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT----ERSRKLAEQELIETSER 1714
Query: 1416 LKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE--EHVVTK 1473
+++L + T L + KK+E L ++E EE + EE + +T
Sbjct: 1715 VQLLHSQN-------TSLINQ----KKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITD 1763
Query: 1474 ARLTVEK-EQAQGELLHVQKELSTALGEIKTLQEKLG-TESAAWNTEKTEMQNSIASLQE 1531
A + E+ ++ Q H+++ IK LQ +L E A K ++Q A ++E
Sbjct: 1764 AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1823
Query: 1532 RLCGGGWEVERAR 1544
G E E+ R
Sbjct: 1824 --LEGELEAEQKR 1834
Score = 66.9 bits (156), Expect = 7e-10
Identities = 166/825 (20%), Positives = 326/825 (39%), Gaps = 80/825 (9%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + +++ L +E +EL ++ + +E DL
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 896
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG 465
QDN + A+E +Q IKN L K+K+ + + E+ AE K ++
Sbjct: 897 QDNLND--AEE------RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948
Query: 466 PDGMQR-----ENRIKELEQEVARSTEVALRLQRELA---EANSKFTGSNPSLMKVPQP- 516
+++ E + ++E+E + L E+A E +K T +L + Q
Sbjct: 949 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1008
Query: 517 -ETVKVSRSSL-TRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTF 574
+ ++V + + S+ Q + DL+ SLE+E +R L A+ + ++ +
Sbjct: 1009 LDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Query: 575 LDKQVMTDNIVTCDIHESETVTNSIQNKMI--HAASTPSSKEKSDSPPLSIDKTTEETQF 632
+D + D + + + + + QN I A ++K I++ EE +
Sbjct: 1069 MDLE--NDKLQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQARIEELEEELEA 1126
Query: 633 HFDL-PYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSI 691
+ + L + + R+EE + +Q++ K R + + +
Sbjct: 1127 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE--MNKKREAEFQKM----RRDL 1180
Query: 692 ETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS 751
E A E + EL EQ L+R ++LE++K K ++ ++TS +
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQ-IDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Query: 752 VTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ K A +R T ++ E RVK+ +E + + + EL+
Sbjct: 1240 IIKAKANLEKVSR----TLEDQANEYRVKL--EEAQRSLNDFTTQRAKLQTENGELARQL 1293
Query: 812 KKPKTLIK--SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD----NEKLQTEN 865
++ + LI +R + QQ DLKRQL+ + + L QS D E+ + E
Sbjct: 1294 EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEET 1353
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTT---QLENELKEALAKIKELEMICQD--EKSEKKV 920
+ L+ S + + TK T Q EL+EA K+ + ++ E K
Sbjct: 1354 EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKC 1413
Query: 921 RFTEATK----KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRI 976
E TK E + L A K +++Q +
Sbjct: 1414 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS- 1472
Query: 977 PKKPTDLTTKL-QLKKMVED--------------LECEIGEMYVVMKNAGLSGKEM-TAK 1020
K+ L+T+L +LK E+ L+ EI ++ + G + E+ +
Sbjct: 1473 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR 1532
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKN---RLQTEIAKLK-DVNAKL-EGDKDV---FANK 1072
+LE E E++S L + ++ +E+ R Q E ++K ++ KL E D+++ N
Sbjct: 1533 KQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592
Query: 1073 YKALENENSNLSNQCKTLTEEM---KNREAQINKLSADLKNATSL 1114
+ +++ ++L + ++ E + K E +N++ L +A +
Sbjct: 1593 QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRM 1637
Score = 62.9 bits (146), Expect = 1e-08
Identities = 160/872 (18%), Positives = 349/872 (40%), Gaps = 82/872 (9%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 943 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1002
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
QQ +++L + L K L Q++ ++E LE +E+ + KL
Sbjct: 1003 EAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVR---MDLERAKRKLEG 1059
Query: 377 AETLCEE-LMD-ENEDMKKELRDLXXXXXXMQDNFR-EDQADEYSSLRRELEQTIKNCRV 433
L +E +MD EN+ ++ E + Q N + ED+ L+++L++
Sbjct: 1060 DLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQARIEE 1119
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RL 492
L +L+ ++E+ +++ ++L EI + ++ ++ E+ + E ++
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKM 1176
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+R+L EA + + +L K S+ G Q D L+ ++ LE+E
Sbjct: 1177 RRDLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS- 1224
Query: 553 REQLRNAEEETANCKQ-VNPPTFLDK--QVMTD--NIVTCDIHESETVTN--SIQNKMIH 605
E ++ T+N +Q + L+K + + D N + E++ N + Q +
Sbjct: 1225 -EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQ 1283
Query: 606 AASTPSSKEKSDSPPLSIDKTTEE---TQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ +++ + L T + TQ DL A N L D +
Sbjct: 1284 TENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCD 1343
Query: 663 SLLLQL-KKMATKARSRKLSPTPPANKLSIETANDNDE-KETDEADPAEMKLLLELNEQE 720
L Q ++ KA +++ + T + D + T+E + A+ KL L + E
Sbjct: 1344 LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1403
Query: 721 ATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1404 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE- 1457
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++
Sbjct: 1458 ---WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEIS 1512
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
+ ++ LE ++L+ E +LQ + ++ +L+ K + + E
Sbjct: 1513 DLTEQLGEGGKNVHELEKVRKQLEVEKLELQ----SALEEAEASLEHEEGKILRAQLEFN 1568
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
+ A+I E ++ +DE+ E +A + + S Q +
Sbjct: 1569 QIKAEI-ERKLAEKDEEME------QAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
L + + Q S R+ + LQ +++D + ++ + V N L
Sbjct: 1622 GDLNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAI 1675
Query: 1019 AKTK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
+ + L+ E++E+R+ + + + + + E+ + + L N+ K
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKK 1731
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+E++ + L ++ + +E +N E + K D
Sbjct: 1732 MESDLTQLQSEVEEAVQECRNAEEKAKKAITD 1763
>X51591-1|CAA35940.1| 1151|Homo sapiens beta-myosin heavy chain (1151
AA) protein.
Length = 1151
Score = 105 bits (252), Expect = 2e-21
Identities = 198/1018 (19%), Positives = 384/1018 (37%), Gaps = 86/1018 (8%)
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
K K L+KS +++ +K + +++ A+ + LE L E LQL
Sbjct: 51 KIKPLLKSAE---REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQV 107
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
A+ D D + ++N++ + AK+KE+ +DE+ E T +K D
Sbjct: 108 QAEQ---DNLADAEERCDQLIKNKI-QLEAKVKEMNERLEDEE-EMNAELTAKKRKLEDE 162
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ--KSFKPRIPKKPTDLTTKLQLK 990
+ + +K+L ++ ++ K+ L Q
Sbjct: 163 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ-- 220
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ ++DL+ E ++ + K AK KLE+++D++ L + +K R+
Sbjct: 221 QALDDLQAEEDKVNTLTK----------AKVKLEQQVDDLEGSLEQE------KKVRMDL 264
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
E AK KLEGD + LEN+ L E +K ++ ++N L+A +++
Sbjct: 265 ERAK-----RKLEGDLKLTQESIMDLENDKQQLE-------ERLKKKDFELNALNARIED 312
Query: 1111 ATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
+L + + + +V+ K+ D ++ L+E+ ++ ++
Sbjct: 313 EQALGSQLQKKLKELQARIEELEEELEAERTARAKVE---KLRSDLSRELEEISERLEEA 369
Query: 1171 GDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK 1230
G KR + R+D A L H EL +
Sbjct: 370 GGATSVQIEMNK--KREAEFQKMRRD----LEEATLQHEATAAALRKKHADSVAELGEQI 423
Query: 1231 DELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK---DVHIKQLEDALRQTT 1287
D LQ + + K LE E + K + ++ +++E I AK + + LED + +
Sbjct: 424 DNLQ----RVKQK---LEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 476
Query: 1288 NDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKS 1347
+ + S ++ R DE +L + + + ++ +
Sbjct: 477 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE 536
Query: 1348 DLAKLENXXXXXXXXXXXX--XXXSSYWEN-KAK-ELDTDLQSERKKLDRMRIAHDKDVK 1403
+ K +N Y E +AK EL L ++ + R ++ D
Sbjct: 537 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 596
Query: 1404 NKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYE 1463
+ EL K KL Q + + + E+T +L++ + + E
Sbjct: 597 QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 656
Query: 1464 LLEEEHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKLGTESAAWNT 1517
L+++ L K E++Q EL QKE LST L ++K E+ +
Sbjct: 657 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR 716
Query: 1518 EKTEMQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRDV-LEHHHDXXXX 1575
E +Q I+ L E+L G + E ++ +L+ + EL++A + + LEH
Sbjct: 717 ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR 776
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
+ ER + +E + E K + EG
Sbjct: 777 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG 836
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI--KNGDKSARI----HRNSI 1689
+N M +L + + +++ + + +L+ Q + + N D I RN++
Sbjct: 837 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 896
Query: 1690 SSTDEEEYRNKVALLEQQVACLEDELCES----RLLASKLNTELVSEKSSAEVRLAEMQS 1745
+ EE R V E+ ++EL E+ +LL S+ NT L+++K + L+++Q+
Sbjct: 897 LQAELEELRAVVEQTERSRKLADEELIETSERVQLLHSQ-NTSLINQKKKMDADLSQLQT 955
Query: 1746 RLNEYEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLLQETSTLARDLRQTL 1799
+ E +E + +A+ A A M KE+D +R+ + +DL+ L
Sbjct: 956 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1013
Score = 99.5 bits (237), Expect = 1e-19
Identities = 176/918 (19%), Positives = 368/918 (40%), Gaps = 79/918 (8%)
Query: 187 IEKERERRSLSKSKEDEKTARYKDERSSTK--DDVNF----LMQVKNSRNSTNLKPPVRG 240
++ E++ L S E EK R ER+ K D+ +M ++N + L+ ++
Sbjct: 241 VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ--LEERLKK 298
Query: 241 GPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR 300
+ +KE Q +IE L++E++ R +VEK +SD L R
Sbjct: 299 KDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSD-LSR 357
Query: 301 RLANIDTANKYTTGRSSEVLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPS 359
L I + G +S +++ +K E DL E+ L + + S
Sbjct: 358 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADS 415
Query: 360 TEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEY 417
QI+ L+ E E E +D+ + + ++ R EDQ +E+
Sbjct: 416 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 475
Query: 418 SSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRI 475
S E ++++ + L+ + K + + +L ++ E E + ++ G Q E+
Sbjct: 476 RSKAEETQRSVND---LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK 532
Query: 476 KELEQEVARSTEVALRLQRE------LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG 529
++LE+EV +A LQ L E + T + L +V +V++ R
Sbjct: 533 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRT 589
Query: 530 GSQEDPAQLLRDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD 588
+ D Q +L+++ ++ A L+E E A C + + + D +V D
Sbjct: 590 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--D 647
Query: 589 IHESETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSI 641
+ S ++ K + + K+K + ++ + +E + F Y
Sbjct: 648 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEES 707
Query: 642 FNHMAANNLRKTAARVEEDNESLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEK 700
H+ ++ ++E+ L QL T K+ A K+ +++A + E
Sbjct: 708 LEHL--ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEA 765
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSN 760
+ + ++ LE N+ +A + R+ E+ E+ ++A + ++ + S +TS +
Sbjct: 766 SLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAE 820
Query: 761 TTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKS 820
T +R K+ E +++E+ +L R+ AE K ++L+K
Sbjct: 821 TRSRNEALRVKKKM--------EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKD 868
Query: 821 RSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK-----KLQLLKN 873
+ D + N DLK + ++E+ ++L+A+ + L A E+ + K ++ +
Sbjct: 869 TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADEELIETSER 928
Query: 874 AKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTL 933
+ L S +N KK +++ +L + +++E C++ + + K T+A + L
Sbjct: 929 VQLLHSQNTSLINQKK--KMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEEL 985
Query: 934 KSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMV 993
K +Q Q L + A K K ++ K + +L+ +
Sbjct: 986 KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENEL 1042
Query: 994 EDLECEIGEMYVVMKNAGLSGKEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEK 1045
E + E M+ + KE+T +T +L+ +D+++ K+ + +
Sbjct: 1043 EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAE 1102
Query: 1046 NRLQTEIAKLKDVNAKLE 1063
+ T ++K + V +L+
Sbjct: 1103 EQANTNLSKFRKVQHELD 1120
Score = 78.2 bits (184), Expect = 3e-13
Identities = 193/1082 (17%), Positives = 411/1082 (37%), Gaps = 82/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 75 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 130
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 131 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----RDIDDLELTLAKVEKEK 184
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 185 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 235
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + EER
Sbjct: 236 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLEER 295
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 296 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 355
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 356 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 415
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 416 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 475
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 476 RSKAEETQRSVND--LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 532
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 533 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 590
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 591 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 650
Query: 1128 XXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 651 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 710
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 711 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 770
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 771 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 830
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 831 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 890
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K D +L SER + L + K DA+L
Sbjct: 891 ERRNNLLQAELEELRAVVEQTERSRKLADEELIETSERVQLLHSQNTSLINQKKKMDADL 950
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 951 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1010
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1011 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1068
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1069 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1128
Query: 1566 LE 1567
E
Sbjct: 1129 AE 1130
Score = 70.1 bits (164), Expect = 7e-11
Identities = 237/1189 (19%), Positives = 466/1189 (39%), Gaps = 146/1189 (12%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + +L+ L +E +EL ++ + +E DL
Sbjct: 51 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 110
Query: 406 QDNFR--EDQADEYSSLRRELEQTIK--NCRV---------LSFKLKKTERKADQLEQEK 452
QDN E++ D+ + +LE +K N R+ L+ K +K E + +L+++
Sbjct: 111 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 170
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E+ +L +E + L
Sbjct: 171 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-- 226
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E +R L A+ +
Sbjct: 227 --QAEEDKVN--TLTKAKVKLE--QQVDDLEGSLEQEKKVRMDLERAKRKLEG------- 273
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
D ++ ++I+ + ++ + + ++ K + + E + + K +E Q
Sbjct: 274 ---DLKLTQESIMDLE-NDKQQLEERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 329
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
+ + + A R A+VE+ L +L+++ S +L A + IE
Sbjct: 330 RIE----ELEEELEAE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSVQIE 378
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSK 748
N E E + + L+ +E A LR+K V EL + + L++ VK+ K
Sbjct: 379 M-NKKREAEFQKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEK 435
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS 808
S K T+ + L E+ + LED+++E R K E +R +L+
Sbjct: 436 EKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVN----DLT 490
Query: 809 LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL-RAK---TQSLEADNEKLQTE 864
+ K +T +N +L RQL E S L R K TQ LE +L+ E
Sbjct: 491 SQRAKLQT------------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 538
Query: 865 NKKLQLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
K L +A +S R D DL + Q E E EA A+++ + E ++ +
Sbjct: 539 VKAKNALAHALQSARHD--CDLLRE---QYEEET-EAKAELQRVLSKANSEVAQWR---- 588
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
TK ETD ++ + + L +A+++ + K +
Sbjct: 589 --TKYETDAIQRTEELEEA---------------KKKLAQRLQEAEEAVEAVNAKCSSLE 631
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
TK +L+ +EDL ++ NA + + + +K + E + K ++ SE +
Sbjct: 632 KTKHRLQNEIEDLMVDVER-----SNAAAAALDKKQRN-FDKILAEWKQKYEESQSELES 685
Query: 1044 ---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
E L TE+ KLK NA E + + EN NL + LTE++ +
Sbjct: 686 SQKEARSLSTELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKT 738
Query: 1101 INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLL 1160
I++L K + + + + Q+ K ++
Sbjct: 739 IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---------KAEIE 789
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+++ +K +++ + ++ + +R + + + L++ +
Sbjct: 790 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 849
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R++ E + LQ+ T+ I L+ +R D + I +E +++L
Sbjct: 850 -RMAAEAQKQVKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEEL 904
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+ QT + +E E R Q + +A + +TE E + +
Sbjct: 905 RAVVEQTERSRKLADEELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 963
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
A+ K+ K S++ E K ++ ++ + +LD A
Sbjct: 964 CRNAEEKA--KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQ 1018
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+K +L L+ +++ LE A KR E + ++K E +++ Y+
Sbjct: 1019 IALKGGKKQLQKLEARVRELENELEAEQKR----NAESVKGMRKSER--RIKELTYQTEE 1072
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ LL + +V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 1073 DRKNLLRLQDLVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 1119
Score = 64.1 bits (149), Expect = 5e-09
Identities = 155/870 (17%), Positives = 341/870 (39%), Gaps = 78/870 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 157 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 216
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 217 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 276
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ +L ++ + +++ L+ + ++QA S L+++L++ L
Sbjct: 277 LTQESIMDLENDKQQLEERLKKKDFELNALNARIEDEQA-LGSQLQKKLKELQARIEELE 335
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQR 494
+L+ ++E+ +++ ++L EI + ++ ++ E+ + E +++R
Sbjct: 336 EELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKMRR 392
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L EA + + +L K S+ G Q D L+ ++ LE+E E
Sbjct: 393 DLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS--E 439
Query: 555 QLRNAEEETANCKQ-VNPPTFLDKQVMT----DNIVTCDIHESETVTNSI--QNKMIHAA 607
++ T+N +Q + L+K T N E++ N + Q +
Sbjct: 440 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 499
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNLRKTAARVEEDNESLL 665
+ S++ + L T + + L L + + A N A + + LL
Sbjct: 500 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 559
Query: 666 LQLKKMATKARSRKLSPTPPANK--LSIETANDNDE-KETDEADPAEMKLLLELNEQEAT 722
+ + T+A++ AN T + D + T+E + A+ KL L E E
Sbjct: 560 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 619
Query: 723 V--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 620 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE--- 671
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++ +
Sbjct: 672 -WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDL 728
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
++ LE ++L+ E +LQ + ++ +L+ K + + E +
Sbjct: 729 TEQLGSSGKTIHELEKVRKQLEAEKMELQ----SALEEAEASLEHEEGKILRAQLEFNQI 784
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
A+I E ++ +DE+ E +A + + S Q +
Sbjct: 785 KAEI-ERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 837
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L + + Q S R+ + LQ +++D + ++ + V N L +
Sbjct: 838 LNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAIVE 891
Query: 1021 TK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+ L+ E++E+R+ + + + + E+ + + L N+ K ++
Sbjct: 892 RRNNLLQAELEELRAVVEQTE----RSRKLADEELIETSERVQLLHSQNTSLINQKKKMD 947
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ S L + + +E +N E + K D
Sbjct: 948 ADLSQLQTEVEEAVQECRNAEEKAKKAITD 977
>BC132667-1|AAI32668.1| 1939|Homo sapiens myosin, heavy chain 6,
cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)
protein.
Length = 1939
Score = 104 bits (250), Expect = 3e-21
Identities = 214/1025 (20%), Positives = 388/1025 (37%), Gaps = 100/1025 (9%)
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
K K L+KS ++++ +K + I++ A+ + LE L E LQL
Sbjct: 837 KIKPLLKSAE---TEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQV 893
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
A+ D D + ++N++ + AK+KE+ +DE+ E T +K D
Sbjct: 894 QAEQ---DNLNDAEERCDQLIKNKI-QLEAKVKEMNERLEDEE-EMNAELTAKKRKLEDE 948
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ--KSFKPRIPKKPTDLTTKLQLK 990
+ + +K+L ++ ++ K+ L Q
Sbjct: 949 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ-- 1006
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ ++DL+ E ++ + K+ K KLE+++D++ L + +K R+
Sbjct: 1007 QALDDLQVEEDKVNSLSKS----------KVKLEQQVDDLEGSLEQE------KKVRMDL 1050
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
E AK KLEGD + LEN+ L E++K +E IN+ ++ +++
Sbjct: 1051 ERAK-----RKLEGDLKLTQESIMDLENDKLQLE-------EKLKKKEFDINQQNSKIED 1098
Query: 1111 ATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
L + + +V+ K+ D ++ L+E+ ++ ++
Sbjct: 1099 EQVLALQLQKKLKENQARIEELEEELEAERTARAKVE---KLRSDLSRELEEISERLEEA 1155
Query: 1171 GDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK 1230
G KR + R+D A L H EL +
Sbjct: 1156 GGATSVQIEMNK--KREAEFQKMRRD----LEEATLQHEATAAALRKKHADSVAELGEQI 1209
Query: 1231 DELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK 1290
D LQ + + K LE E + K + ++ +++E I AK LE R T D+
Sbjct: 1210 DNLQ----RVKQK---LEKEKSEFKLELDDVTSNMEQIIKAK----ANLEKVSR-TLEDQ 1257
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA---ESSAAKLEMAQLKS 1347
+E V++ E + Q E +LE+ EA + + KL Q
Sbjct: 1258 ANEYR--VKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQME 1315
Query: 1348 DLAK-LENXXXXXXXXXXXXXXX--------SSYWEN-KAK-ELDTDLQSERKKLDRMRI 1396
DL + LE Y E +AK EL L ++ + R
Sbjct: 1316 DLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1375
Query: 1397 AHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
++ D + EL K KL Q++ + + E+T +L++ + + E
Sbjct: 1376 KYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1435
Query: 1457 ELTGKYELLEEEHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKLGT 1510
L+++ L K E++Q EL QKE LST L ++K E+
Sbjct: 1436 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1495
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRDV-LEH 1568
+ E +Q I+ L E+L GG V E ++ +L+ + EL++A + + LEH
Sbjct: 1496 HLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEH 1555
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITD 1628
+ ER + +E + E+
Sbjct: 1556 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR 1615
Query: 1629 TKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI--KNGDKSARI-- 1684
K + EG +N M +L + + +++ + + +L+ Q + + N D I
Sbjct: 1616 VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675
Query: 1685 --HRNSISSTDEEEYRNKVALLEQQVACLEDELCES----RLLASKLNTELVSEKSSAEV 1738
RN++ + EE R V E+ E EL E+ +LL S+ NT L+++K E
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ-NTSLINQKKKMES 1734
Query: 1739 RLAEMQSRLNEYEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLLQETSTLARD 1794
L ++QS + E +E + +A+ A A M KE+D +R+ + +D
Sbjct: 1735 DLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 1794
Query: 1795 LRQTL 1799
L+ L
Sbjct: 1795 LQHRL 1799
Score = 104 bits (250), Expect = 3e-21
Identities = 190/968 (19%), Positives = 383/968 (39%), Gaps = 85/968 (8%)
Query: 179 NSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTN----L 234
NS K ++ E++ L S E EK R ER+ K + + + ++ + N L
Sbjct: 1020 NSLSKS-KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQL 1078
Query: 235 KPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEK 294
+ ++ + +KE Q +IE L++E++ R +VEK +
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLR 1138
Query: 295 SDILLRRLANIDTANKYTTGRSSEVLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESE 353
SD L R L I + G +S +++ +K E DL E+ L +
Sbjct: 1139 SD-LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL--EEATLQHEATAAALR 1195
Query: 354 LETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--E 411
+ S QI+ L+ E E E +D+ + + ++ R E
Sbjct: 1196 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLE 1255
Query: 412 DQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG--M 469
DQA+EY R +LE+ ++ + + K + + +L ++ E E + ++ G
Sbjct: 1256 DQANEY---RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQ 1312
Query: 470 QRENRIKELEQEVARSTEVALRLQRE------LAEANSKFTGSNPSLMKVPQPETVKVSR 523
Q E+ ++LE+E +A LQ L E + T + L +V +V++
Sbjct: 1313 QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1372
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEET-ANCKQVNPPTFLDKQVMTD 582
R + D Q +L+++ ++ A + A E A C + + + D
Sbjct: 1373 ---WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFD 635
+V D+ S ++ K + + K+K + ++ + +E + F
Sbjct: 1430 LMV--DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487
Query: 636 LPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETA 694
Y H+ ++ ++E+ L QL + K+ KL +++A
Sbjct: 1488 NAYEESLEHL--ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
+ E + + ++ LE N+ +A + RK+ E +++ E K+ + + + +
Sbjct: 1546 LEEAEASLEHEEGKILRAQLEFNQIKAEI-ERKLAEKDEEMEQAKRNHQRVVDSL----Q 1600
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
TS + T +R + K+ E +++E+ +L R+ AE K
Sbjct: 1601 TSLDAETRSRNEVLRVKKKM--------EGDLNEMEIQLSH----ANRMAAEAQKQVKSL 1648
Query: 815 KTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ-----TENKK 867
++L+K + D + N DLK + ++E+ ++L+A+ + L A E+ + E +
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL 1708
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
++ + + L S +N KK ++E++L + ++++E C++ + + K T+A
Sbjct: 1709 IETSERVQLLHSQNTSLINQKK--KMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAM 1766
Query: 928 KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL 987
+ LK +Q Q L + A K K ++ K
Sbjct: 1767 M-AEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK--------- 1816
Query: 988 QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR 1047
L+ V +LE GE+ K S K M + KE+ + KN + ++
Sbjct: 1817 -LEARVRELE---GELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDK 1872
Query: 1048 LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
LQ ++ K + E + +K++ +++E E E+Q+NKL A
Sbjct: 1873 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAE-------ERADIAESQVNKLRAK 1925
Query: 1108 LKNATSLQ 1115
++ + Q
Sbjct: 1926 SRDIGAKQ 1933
Score = 74.1 bits (174), Expect = 5e-12
Identities = 182/1033 (17%), Positives = 402/1033 (38%), Gaps = 89/1033 (8%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
++++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 861 IKETLEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ- 916
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 917 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----KDIDDLELTLAKVEKEK 970
Query: 662 ESLLLQLKKMATKARS-----RKLSPTPPANKLSIETANDNDEKETDEADP---AEMKLL 713
+ ++K + + KL+ A + + + A D+ + E D+ + +++KL
Sbjct: 971 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLE 1030
Query: 714 LELNEQEATVLR-RKVE-ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS---LT 768
++++ E ++ + +KV +LE+ K L+ +K I + ++ +
Sbjct: 1031 QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDIN 1090
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
++K+ +E+V L+ ++KKL E + E L EL + + K RS
Sbjct: 1091 QQNSKIEDEQVLALQ-----LQKKLKENQARIEELEEELEAERTARAKVEKLRS------ 1139
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
DL R+L+ I + T N+K + E +K++ +L+ + K
Sbjct: 1140 ---DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1196
Query: 889 KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
K EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1197 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLED 1256
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
+ +SL D + + ++ + +L +L+ K+ + + G++ +
Sbjct: 1257 QANEYRVKLEEAQRSLNDFTTQ--RAKLQTENGELARQLEEKEALIS-QLTRGKLSYTQQ 1313
Query: 1009 NAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKD 1067
L +++ + K + + +++D + E+ +TE A+L+ V +K +
Sbjct: 1314 MEDLK-RQLEEEGKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371
Query: 1068 VFANKYKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCM 1122
+ KY+ L K L + +++ E + ++A K LQ + D M
Sbjct: 1372 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431
Query: 1123 XXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKL---LKEVGDKTKKIGDXXXXXX 1178
+ + K ++ +++L KE + ++
Sbjct: 1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1491
Query: 1179 XXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQA 1235
+ +++ ++ ++ L ++L +E L S +E +A
Sbjct: 1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEA 1551
Query: 1236 RFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEAT 1295
E K + + E +KA+ E K+ + + + +++ D+L QT+ D +
Sbjct: 1552 SLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSL-QTSLDAETRSR 1610
Query: 1296 SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENX 1355
+ V V+ + + +LN +I+L ++ A+ ++ L+S L +
Sbjct: 1611 NEVLRVKKK------------MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Query: 1356 XXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGK 1415
+ E + L +L+ R +++ ++ K + EL +
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT----ERSRKLAEQELIETSER 1714
Query: 1416 LKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE--EHVVTK 1473
+++L + T L + KK+E L ++E EE + EE + +T
Sbjct: 1715 VQLLHSQN-------TSLINQ----KKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITD 1763
Query: 1474 ARLTVEK-EQAQGELLHVQKELSTALGEIKTLQEKLG-TESAAWNTEKTEMQNSIASLQE 1531
A + E+ ++ Q H+++ IK LQ +L E A K ++Q A ++E
Sbjct: 1764 AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1823
Query: 1532 RLCGGGWEVERAR 1544
G E E+ R
Sbjct: 1824 --LEGELEAEQKR 1834
Score = 72.1 bits (169), Expect = 2e-11
Identities = 172/825 (20%), Positives = 332/825 (40%), Gaps = 80/825 (9%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + +++ L +E +EL ++ + +E DL
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 896
Query: 406 QDNFR--EDQADEYSSLRRELEQTIK--NCRVLSFKLKKTE--RKADQLEQEKAEHEKKL 459
QDN E++ D+ + +LE +K N R+ + E K +LE E +E +K +
Sbjct: 897 QDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDI 956
Query: 460 --LEIVGGPDGMQR---ENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVP 514
LE+ ++ EN++K L +E+A E+ +L +E + L
Sbjct: 957 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL---- 1012
Query: 515 QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTF 574
Q E KV+ SL++ S+ Q + DL+ SLE+E +R L A+ + ++ +
Sbjct: 1013 QVEEDKVN--SLSK--SKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Query: 575 LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPS--SKEKSDSPPLSIDKTTEETQF 632
+D + D + + + + + QN I + ++K I++ EE +
Sbjct: 1069 MDLE--NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEA 1126
Query: 633 HFDL-PYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSI 691
+ + L + + R+EE + +Q++ K R + + +
Sbjct: 1127 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE--MNKKREAEFQKM----RRDL 1180
Query: 692 ETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS 751
E A E + EL EQ L+R ++LE++K K ++ ++TS +
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQ-IDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Query: 752 VTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ K A +R T ++ E RVK+ +E + + + EL+
Sbjct: 1240 IIKAKANLEKVSR----TLEDQANEYRVKL--EEAQRSLNDFTTQRAKLQTENGELARQL 1293
Query: 812 KKPKTLIK--SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD----NEKLQTEN 865
++ + LI +R + QQ DLKRQL+ + + L QS D E+ + E
Sbjct: 1294 EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEET 1353
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTT---QLENELKEALAKIKELEMICQD--EKSEKKV 920
+ L+ S + + TK T Q EL+EA K+ + ++ E K
Sbjct: 1354 EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKC 1413
Query: 921 RFTEATK----KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRI 976
E TK E + L A K +++Q +
Sbjct: 1414 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS- 1472
Query: 977 PKKPTDLTTKL-QLKKMVED--------------LECEIGEMYVVMKNAGLSGKEM-TAK 1020
K+ L+T+L +LK E+ L+ EI ++ + G + E+ +
Sbjct: 1473 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR 1532
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKN---RLQTEIAKLK-DVNAKL-EGDKDV---FANK 1072
+LE E E++S L + ++ +E+ R Q E ++K ++ KL E D+++ N
Sbjct: 1533 KQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592
Query: 1073 YKALENENSNLSNQCKTLTEEM---KNREAQINKLSADLKNATSL 1114
+ +++ ++L + ++ E + K E +N++ L +A +
Sbjct: 1593 QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRM 1637
Score = 62.5 bits (145), Expect = 1e-08
Identities = 160/872 (18%), Positives = 349/872 (40%), Gaps = 82/872 (9%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 943 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1002
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
QQ +++L + L K L Q++ ++E LE +E+ + KL
Sbjct: 1003 EAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVR---MDLERAKRKLEG 1059
Query: 377 AETLCEE-LMD-ENEDMKKELRDLXXXXXXMQDNFR-EDQADEYSSLRRELEQTIKNCRV 433
L +E +MD EN+ ++ E + Q N + ED+ L+++L++
Sbjct: 1060 DLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEE 1119
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RL 492
L +L+ ++E+ +++ ++L EI + ++ ++ E+ + E ++
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKM 1176
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+R+L EA + + +L K S+ G Q D L+ ++ LE+E
Sbjct: 1177 RRDLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS- 1224
Query: 553 REQLRNAEEETANCKQ-VNPPTFLDK--QVMTD--NIVTCDIHESETVTN--SIQNKMIH 605
E ++ T+N +Q + L+K + + D N + E++ N + Q +
Sbjct: 1225 -EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQ 1283
Query: 606 AASTPSSKEKSDSPPLSIDKTTEE---TQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ +++ + L T + TQ DL A N L D +
Sbjct: 1284 TENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCD 1343
Query: 663 SLLLQL-KKMATKARSRKLSPTPPANKLSIETANDNDE-KETDEADPAEMKLLLELNEQE 720
L Q ++ KA +++ + T + D + T+E + A+ KL L + E
Sbjct: 1344 LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1403
Query: 721 ATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1404 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE- 1457
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++
Sbjct: 1458 ---WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEIS 1512
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
+ ++ LE ++L+ E +LQ + ++ +L+ K + + E
Sbjct: 1513 DLTEQLGEGGKNVHELEKVRKQLEVEKLELQ----SALEEAEASLEHEEGKILRAQLEFN 1568
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
+ A+I E ++ +DE+ E +A + + S Q +
Sbjct: 1569 QIKAEI-ERKLAEKDEEME------QAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
L + + Q S R+ + LQ +++D + ++ + V N L
Sbjct: 1622 GDLNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAI 1675
Query: 1019 AKTK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
+ + L+ E++E+R+ + + + + + E+ + + L N+ K
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKK 1731
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+E++ + L ++ + +E +N E + K D
Sbjct: 1732 MESDLTQLQSEVEEAVQECRNAEEKAKKAITD 1763
>D00943-1|BAA00791.1| 1939|Homo sapiens cardiac alpha-myosin heavy
chain protein.
Length = 1939
Score = 104 bits (249), Expect = 4e-21
Identities = 212/1025 (20%), Positives = 389/1025 (37%), Gaps = 100/1025 (9%)
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
K K L+KS ++++ +K + I++ A+ + LE L E LQL
Sbjct: 837 KIKPLLKSAE---TEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQV 893
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
A+ D D + ++N++ + AK+KE+ +DE+ E T +K D
Sbjct: 894 QAEQ---DNLNDAEERCDQLIKNKI-QLEAKVKEMNERLEDEE-EMNAELTAKKRKLEDE 948
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ--KSFKPRIPKKPTDLTTKLQLK 990
+ + +K+L ++ ++ K+ L Q
Sbjct: 949 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ-- 1006
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ ++DL+ E ++ + K+ K KLE+++D++ L + +K R+
Sbjct: 1007 QALDDLQAEEDKVNTLSKS----------KVKLEQQVDDLEGSLEQE------KKVRMDL 1050
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
E AK KLEGD + LEN+ L E++K +E IN+ ++ +++
Sbjct: 1051 ERAK-----RKLEGDLKLTQESIMDLENDKLQLE-------EKLKKKEFDINQQNSKIED 1098
Query: 1111 ATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
L + + +V+ K+ D ++ L+E+ ++ ++
Sbjct: 1099 EQVLALQLQKKLKENQARIEELEEELEAERTARAKVE---KLRSDLSRELEEISERLEEA 1155
Query: 1171 GDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK 1230
G KR + R+D A L H EL +
Sbjct: 1156 GGATSVQIEMNK--KREAEFQKMRRD----LEEATLQHEATAAALRKKHADSVAELGEQI 1209
Query: 1231 DELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK 1290
D LQ + + K LE E + K + ++ +++E I AK LE R T D+
Sbjct: 1210 DNLQ----RVKQK---LEKEKSEFKLELDDVTSNMEQIIKAK----ANLEKVSR-TLEDQ 1257
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA---ESSAAKLEMAQLKS 1347
+E V++ E + Q E +LE+ EA + + KL Q
Sbjct: 1258 ANEYR--VKLEEAQRSLNDFTTQRAKLQTENGELSRQLEEKEALISQLTRGKLSYTQQME 1315
Query: 1348 DLAK-LENXXXXXXXXXXXXXXX--------SSYWEN-KAK-ELDTDLQSERKKLDRMRI 1396
DL + LE Y E +AK EL L ++ + R
Sbjct: 1316 DLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQCRT 1375
Query: 1397 AHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
++ D + EL K KL Q++ + + E+T +L++ + + E
Sbjct: 1376 KYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1435
Query: 1457 ELTGKYELLEEEHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKLGT 1510
L+++ L K E++Q EL QKE LST L ++K E+
Sbjct: 1436 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1495
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRDV-LEH 1568
+ E +Q I+ L E+L GG V E ++ +L+ + EL++A + + LEH
Sbjct: 1496 HLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEH 1555
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITD 1628
+ ER + +E + E+
Sbjct: 1556 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR 1615
Query: 1629 TKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI--KNGDKSARI-- 1684
K + EG +N M +L + + +++ + + +L+ Q + + N D I
Sbjct: 1616 VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675
Query: 1685 --HRNSISSTDEEEYRNKVALLEQQVACLEDELCES----RLLASKLNTELVSEKSSAEV 1738
RN++ + EE R V E+ + EL E+ +LL S+ NT L+++K +
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQ-NTSLINQKKKMDA 1734
Query: 1739 RLAEMQSRLNEYEEERLLSSGRARVA-GLATRMELAWHKERDEQ---QRLLQETSTLARD 1794
L+++QS + E +E + +A+ A A M KE+D +R+ + +D
Sbjct: 1735 DLSQLQSEVEEAVQECRNAEEKAKKAITHAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 1794
Query: 1795 LRQTL 1799
L+ L
Sbjct: 1795 LQHRL 1799
Score = 100 bits (240), Expect = 5e-20
Identities = 174/881 (19%), Positives = 351/881 (39%), Gaps = 80/881 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSD-LSRELEEISERLEEAGGATSVQIE 1164
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 1165 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1222
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQA+EY R +LE+ ++ + +
Sbjct: 1223 KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEY---RVKLEEAQRSLNDFTTQR 1279
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+E +A LQ
Sbjct: 1280 AKLQTENGELSRQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSAR 1339
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 1340 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQC---RTKYETDAIQRTEELEEAKKKLA 1396
Query: 551 DLREQLRNAEEET-ANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
+ A E A C + + + D +V D+ S ++ K +
Sbjct: 1397 QRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 1454
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 1455 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 1512
Query: 663 SLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL + K+ KL +++A + E + + ++ LE N+ +A
Sbjct: 1513 DLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1572
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ RK+ E +++ E K+ + + + +TS + T +R + K+
Sbjct: 1573 EI-ERKLAEKDEEMEQAKRNHQRVVDSL----QTSLDAETRSRNEVLRVKKKM------- 1620
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 1621 -EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKK-----LQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ ++L+A+ + L A E+ + K ++ + + L S +N KK +++
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKK--KMD 1733
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + ++++E C++ + + K T A + LK +Q
Sbjct: 1734 ADLSQLQSEVEEAVQECRNAEEKAKKAITHAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1792
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K L+ V +LE GE+ K S
Sbjct: 1793 KDLQHRLDEAEQIALKGGKKQLQK----------LEARVRELE---GELEAEQKRNAESV 1839
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK 1074
K M + KE+ + KN + ++LQ ++ K + E + +K++
Sbjct: 1840 KGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1899
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+++E E E+Q+NKL A ++ + Q
Sbjct: 1900 KVQHELDEAE-------ERADIAESQVNKLRAKSRDIGAKQ 1933
Score = 77.8 bits (183), Expect = 4e-13
Identities = 196/1088 (18%), Positives = 423/1088 (38%), Gaps = 94/1088 (8%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
++++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 861 IKETLEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ- 916
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 917 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----KDIDDLELTLAKVEKEK 970
Query: 662 ESLLLQLKKMATKARS-----RKLSPTPPANKLSIETANDNDEKETDEADP---AEMKLL 713
+ ++K + + KL+ A + + + A D+ + E D+ + +++KL
Sbjct: 971 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLSKSKVKLE 1030
Query: 714 LELNEQEATVLR-RKVE-ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS---LT 768
++++ E ++ + +KV +LE+ K L+ +K I + ++ +
Sbjct: 1031 QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDIN 1090
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
++K+ +E+V L+ ++KKL E + E L EL + + K RS
Sbjct: 1091 QQNSKIEDEQVLALQ-----LQKKLKENQARIEELEEELEAERTARAKVEKLRS------ 1139
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
DL R+L+ I + T N+K + E +K++ +L+ + K
Sbjct: 1140 ---DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1196
Query: 889 KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
K EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1197 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLED 1256
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
+ +SL D + + ++ + +L+ +L+ K+ + + G++ +
Sbjct: 1257 QANEYRVKLEEAQRSLNDFTTQ--RAKLQTENGELSRQLEEKEALIS-QLTRGKLSYTQQ 1313
Query: 1009 NAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKD 1067
L +++ + K + + +++D + E+ +TE A+L+ V +K +
Sbjct: 1314 MEDLK-RQLEEEGKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371
Query: 1068 VFANKYKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCM 1122
KY+ L K L + +++ E + ++A K LQ + D M
Sbjct: 1372 QCRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431
Query: 1123 XXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL---LKEVGDKTKKIGDXXXXXX 1178
+ + K ++ +++L KE + ++
Sbjct: 1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1491
Query: 1179 XXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI---ELTSEKDELQA 1235
+ +++ ++ ++ L ++L + EL S +E +A
Sbjct: 1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEA 1551
Query: 1236 RFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEAT 1295
E K + + E +KA+ E K+ + + + +++ D+L QT+ D +
Sbjct: 1552 SLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSL-QTSLDAETRSR 1610
Query: 1296 SPV---------EMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLK 1346
+ V ++ EM Q ++ + + L+ T+ + A LK
Sbjct: 1611 NEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1670
Query: 1347 SDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVK 1403
++A +E E K D +L SER + L + K
Sbjct: 1671 ENIAIVERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKK 1730
Query: 1404 NKDAELATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-EL 1458
DA+L+ L+ +++ Q N+ AK+ IT EE K+ + S LE+ + E
Sbjct: 1731 KMDADLSQLQSEVEEAVQECRNAEEKAKKAITHAAMMAEELKKEQDTSAHLERMKKNMEQ 1790
Query: 1459 TGK---YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLG 1509
T K + L E E + K +L + +GEL QK + ++ ++ + ++
Sbjct: 1791 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRI- 1849
Query: 1510 TESAAWNTEKTE-----MQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAA 1559
+ + TE+ + +Q+ + LQ ++ + E A A + + + EL A
Sbjct: 1850 -KELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1908
Query: 1560 NDRRDVLE 1567
+R D+ E
Sbjct: 1909 EERADIAE 1916
Score = 73.7 bits (173), Expect = 6e-12
Identities = 172/825 (20%), Positives = 329/825 (39%), Gaps = 80/825 (9%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + +++ L +E +EL ++ + +E DL
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 896
Query: 406 QDNFR--EDQADEYSSLRRELEQTIK--NCRVLSFKLKKTE--RKADQLEQEKAEHEKKL 459
QDN E++ D+ + +LE +K N R+ + E K +LE E +E +K +
Sbjct: 897 QDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDI 956
Query: 460 --LEIVGGPDGMQR---ENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVP 514
LE+ ++ EN++K L +E+A E+ +L +E + L
Sbjct: 957 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL---- 1012
Query: 515 QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTF 574
Q E KV+ T S+ Q + DL+ SLE+E +R L A+ + ++ +
Sbjct: 1013 QAEEDKVN----TLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Query: 575 LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPS--SKEKSDSPPLSIDKTTEETQF 632
+D + D + + + + + QN I + ++K I++ EE +
Sbjct: 1069 MDLE--NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEA 1126
Query: 633 HFDL-PYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSI 691
+ + L + + R+EE + +Q++ K R + + +
Sbjct: 1127 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE--MNKKREAEFQKM----RRDL 1180
Query: 692 ETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS 751
E A E + EL EQ L+R ++LE++K K ++ ++TS +
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQ-IDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Query: 752 VTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ K A +R T ++ E RVK+ +E + + + ELS
Sbjct: 1240 IIKAKANLEKVSR----TLEDQANEYRVKL--EEAQRSLNDFTTQRAKLQTENGELSRQL 1293
Query: 812 KKPKTLIK--SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD----NEKLQTEN 865
++ + LI +R + QQ DLKRQL+ + + L QS D E+ + E
Sbjct: 1294 EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEET 1353
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTT---QLENELKEALAKIKELEMICQD--EKSEKKV 920
+ L+ S + + TK T Q EL+EA K+ + ++ E K
Sbjct: 1354 EAKAELQRVLSKANSEVAQCRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKC 1413
Query: 921 RFTEATK----KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRI 976
E TK E + L A K +++Q +
Sbjct: 1414 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS- 1472
Query: 977 PKKPTDLTTKL-QLKKMVED--------------LECEIGEMYVVMKNAGLSGKEM-TAK 1020
K+ L+T+L +LK E+ L+ EI ++ + G + E+ +
Sbjct: 1473 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR 1532
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKN---RLQTEIAKLK-DVNAKL-EGDKDV---FANK 1072
+LE E E++S L + ++ +E+ R Q E ++K ++ KL E D+++ N
Sbjct: 1533 KQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592
Query: 1073 YKALENENSNLSNQCKTLTEEM---KNREAQINKLSADLKNATSL 1114
+ +++ ++L + ++ E + K E +N++ L +A +
Sbjct: 1593 QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRM 1637
Score = 62.1 bits (144), Expect = 2e-08
Identities = 161/832 (19%), Positives = 342/832 (41%), Gaps = 76/832 (9%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 943 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1002
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
QQ +++L + L K L Q++ ++E LE +E+ + KL
Sbjct: 1003 EAHQQALDDLQAEEDKVNTLSKSKVKLEQQVDDLEGSLEQEKKVR---MDLERAKRKLEG 1059
Query: 377 AETLCEE-LMD-ENEDMKKELRDLXXXXXXMQDNFR-EDQADEYSSLRRELEQTIKNCRV 433
L +E +MD EN+ ++ E + Q N + ED+ L+++L++
Sbjct: 1060 DLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEE 1119
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RL 492
L +L+ ++E+ +++ ++L EI + ++ ++ E+ + E ++
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKM 1176
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+R+L EA + + +L K S+ G Q D L+ ++ LE+E
Sbjct: 1177 RRDLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS- 1224
Query: 553 REQLRNAEEETANCKQ-VNPPTFLDK--QVMTD--NIVTCDIHESETVTN--SIQNKMIH 605
E ++ T+N +Q + L+K + + D N + E++ N + Q +
Sbjct: 1225 -EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQ 1283
Query: 606 AASTPSSKEKSDSPPLSIDKTTEE---TQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ S++ + L T + TQ DL A N L D +
Sbjct: 1284 TENGELSRQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCD 1343
Query: 663 SLLLQL-KKMATKARSRKLSPTPPANKLSIETANDNDE-KETDEADPAEMKLLLELNEQE 720
L Q ++ KA +++ + T + D + T+E + A+ KL L + E
Sbjct: 1344 LLREQYEEETEAKAELQRVLSKANSEVAQCRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1403
Query: 721 ATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1404 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE- 1457
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++
Sbjct: 1458 ---WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEIS 1512
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAK-SLRSDKALDLNTK-KTTQLEN 895
+ ++ LE ++L+ E +LQ L+ A+ SL ++ L + + Q++
Sbjct: 1513 DLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1572
Query: 896 ELKEALA-KIKELEMICQDEK---SEKKVRFTEATKKETDTLKSK---QXXXXXXXXXXX 948
E++ LA K +E+E ++ + + T+ + L+ K +
Sbjct: 1573 EIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLS 1632
Query: 949 XXXXXXXXXQATLKSLKD---DAQKSFKPRIPKKPTDLTTKLQLKKMVED-LECEIGEMY 1004
Q +KSL+ D Q + + DL + + + + L+ E+ E+
Sbjct: 1633 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAV-RANDDLKENIAIVERRNNLLQAELEELR 1691
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK 1056
V++ S K A +L + + ++ S+N S N+K ++ ++++L+
Sbjct: 1692 AVVEQTERSRK--LADRELIETSERVQLLHSQNTS-LINQKKKMDADLSQLQ 1740
>X82834-1|CAA58041.1| 2185|Homo sapiens 256 kD golgin protein.
Length = 2185
Score = 103 bits (247), Expect = 6e-21
Identities = 271/1333 (20%), Positives = 507/1333 (38%), Gaps = 123/1333 (9%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
+ + + Q ++ L+ E +L K+ VE +K D+ A+ + ++
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 323 QQKVNELT-THNEDLRDEKKHLTQ-KIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+QKV LT + L D K Q K +E E E Q ++IE L KL A E
Sbjct: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
Query: 381 CEELMDENE----DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK------- 429
L +E E + +K++ + MQ+ ++ D+ + L++ELE T
Sbjct: 938 IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997
Query: 430 --NCRVLSFKLKKTERKAD---QLEQEKAEHEKKLLEIVGGP--DGMQ-RENRIKELEQE 481
N ++L + +D +LE + E + L E+ D + E ++ + +E
Sbjct: 998 QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE 1057
Query: 482 VARSTEVALR-LQRELAEANSK---FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ 537
+ E+ L+ ++E+AE K F + K + + T QE Q
Sbjct: 1058 LQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQ 1117
Query: 538 LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQ-VMTDNIVTCDIHESETVT 596
+ + E L+ L E + K + TFL +Q V + D + +T
Sbjct: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLN--KSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175
Query: 597 NSIQNKMIHAASTPSSKEKS----DSPPLSIDKTTEETQFHFDL--PYLSIFNHMAANNL 650
+ ++ S SS EKS + L K +EE D+ N L
Sbjct: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL 1235
Query: 651 RKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
++ S + + TK + L T ++L + +E+ T +
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
LE E + ++ +E L +KEAL+K+ S K S + S N
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE--KESCITQLKKELSENIN 1353
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
+ L +E +K + EI + K+L + +L +SL++K+ S D++
Sbjct: 1354 AVTLMKEELKEKKVEISSLSKQLTDLN---VQLQNSISLSEKEAAI---SSLRKQYDEEK 1407
Query: 831 VDLKRQLQVIEQEASVL-RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+L Q+Q + + L + K +LE ++ NK + K A+S + NT K
Sbjct: 1408 CELLDQVQDLSFKVDTLSKEKISALEQVDD---WSNKFSEWKKKAQSRFTQHQ---NTVK 1461
Query: 890 TTQLENEL--KEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS---KQXXXXXXX 944
Q++ EL KEA K +++ ++ ++E ++ RF + K E + KS K+
Sbjct: 1462 ELQIQLELKSKEAYEKDEQINLL-KEELDQQNKRF-DCLKGEMEDDKSKMEKKESNLETE 1519
Query: 945 XXXXXXXXXXXXXQATLKSLK----DDAQKSFKPRIPKKPTDLTTKLQ-LKKMVEDLECE 999
T K+++ ++ K++ + + +L KLQ +++ E+ +
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLE---KEIDEIRSKLSKNDSEFTNEKNRLQTE-IAKL 1055
+ E K L + + K +LE KE++ + + + E ++RL++E AKL
Sbjct: 1580 VKE--AEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKL 1637
Query: 1056 KDVNAKLEG-----DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
++ K E K + + + E + L +++ RE +++ L LK+
Sbjct: 1638 AELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697
Query: 1111 ATSLQT-TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQ----DKNKLLKEVGD 1165
S Q+ T+ + + Q +K KLL+ VG
Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ 1757
Query: 1166 KTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-- 1223
+ ++ C+ E+ + Q L +++ S
Sbjct: 1758 EKEE-----TVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE-ELEEKNKKYSLI 1811
Query: 1224 ----IELTSEKDELQARFIKTESKFITLEAEMRDLKAD---YENKITSLES-TIAAKDVH 1275
+E K+ +QA+ E+ F ++ +++ + E KI L+S + K+VH
Sbjct: 1812 VAQHVEKEGGKNNIQAK-QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Query: 1276 IKQLEDALRQTTN----DKYDEATSPVEMVEMRXXXXXXX-----XXXXXXQDELNNAKI 1326
++E+ + + D P E++E + + N+ +
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEF 1930
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQ- 1385
KL E E E+ +L+ DL L E K K+ DL+
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQER--EEKIKQEQEDLEL 1988
Query: 1386 SERKKLDRMRIAHDKDVKNKDAEL-ATLKGKL--------KILE---QNSGAGAKRITEL 1433
L ++ + + K+ EL T+K + ++LE + + K+I E
Sbjct: 1989 KHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK 2048
Query: 1434 KQEYEETVKKLEHSLALEKAEYEELTGKYELLEE--EHVVTKARLTVEKEQAQGELLHVQ 1491
+ + T K+ E L A EE+T K L+ E + K + +E+E+ G
Sbjct: 2049 DDDLKRTAKRYEEIL---DAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTI 2105
Query: 1492 KELSTALGEIKTL 1504
EL T L + TL
Sbjct: 2106 MELQTQLAQKTTL 2118
Score = 95.5 bits (227), Expect = 2e-18
Identities = 278/1489 (18%), Positives = 576/1489 (38%), Gaps = 113/1489 (7%)
Query: 154 QTQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEK-ERERRSLSKSKEDEKTARYKD-- 210
+T+L K+ A K+Q+LK Q E E EK E+E+ +L K KE A ++
Sbjct: 613 KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 672
Query: 211 ERSSTKDDVNFL-MQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEY 269
E++ K DV ++ +S S LK + +D +
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 732
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKS---DILLRR-----------LANIDTANKYTTG- 314
Q Q++ + +E ++ +R E+ K++ ++LL+ + N++ K + G
Sbjct: 733 QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792
Query: 315 --RSSEVLKLQQKVNELTTHNEDLRDEK-KHLTQKIREIESE--LETRP--STEAQTRQI 367
++S L + Q T +E+ L QK+ ++E+E L T+ EAQ + +
Sbjct: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852
Query: 368 -EQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXX-MQDNFREDQADEYSSLRRE-- 423
+L A + + L ++L +N +M+++++ L ++D +E + + + +E
Sbjct: 853 CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM 912
Query: 424 ----LEQTIKNCRVLSFKLKKTERKADQLEQEKA----EHEKKLLEIVGGPDGMQRENRI 475
E K +L+ KL E L +E EKK+ ++ MQ +
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Query: 476 KELEQEVARSTEV---ALRLQR----------ELAEANSKFTGSNPSLMKVPQPETVKVS 522
K L+QE E+ AL L + E+A+ANS S ++ Q E ++ S
Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE-S 1031
Query: 523 RSSLTRGGSQEDPAQLLRDLQDSLEREADLRE-QLRNAEEETANCKQVNPPTFLDKQVMT 581
+ + R + + + L E ++ E QL+ E+E A KQ +K+ M
Sbjct: 1032 LTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMN 1091
Query: 582 DNIVTCDIH--ESETVTNSIQNKM------IHAASTPSSKEKSDSPPLSID--KTTEETQ 631
I + +T N +Q ++ +++ + +K K+ L +D K+ +E
Sbjct: 1092 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
Query: 632 FH----FDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN 687
F +L L+ + + L +E+ +SL +K + L +
Sbjct: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
Query: 688 KLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTS 747
+L+I+ D K+T+ A+ L+ ++ + + ++ + +K+ L
Sbjct: 1212 ELAIQL--DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEA---LLI 1266
Query: 748 KISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
K +V++ A R LT N L + +++E ++ + D E L E
Sbjct: 1267 KTCTVSELEA-----QLRQLTEEQNTL-NISFQQATHQLEEKENQIKSMKADIESLVTEK 1320
Query: 808 SLAQKKPKTLIKSRSLDAS--DQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
QK+ ++ S S Q +L + + L+ K + + +++L N
Sbjct: 1321 EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN 1380
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEA 925
+LQ N+ SL +A + +K Q + E E L ++++L D S++K+ E
Sbjct: 1381 VQLQ---NSISLSEKEAAISSLRK--QYDEEKCELLDQVQDLSFKV-DTLSKEKISALEQ 1434
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT 985
++ S+ Q LKS K+ +K + + K+ D
Sbjct: 1435 VDDWSNKF-SEWKKKAQSRFTQHQNTVKELQIQLELKS-KEAYEKDEQINLLKEELDQQN 1492
Query: 986 KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK 1045
K + + ++E + +M N K TA+ +E E D I K + +S K
Sbjct: 1493 K-RFDCLKGEMEDDKSKMEKKESNLETELKSQTARI-MELE-DHITQKTIEIESLNEVLK 1549
Query: 1046 NRLQTEIAKLKDVNAKLEGDKDVFA---NKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
N Q + + K++ KL+ +++ N+ K E + L NQ ++ E++ ++ ++
Sbjct: 1550 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE 1609
Query: 1103 KLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLK- 1161
++ +K+ + D + + +++++ + + K
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1669
Query: 1162 ---EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLST-----RKDRVTXXXXXXXXXXXQAV 1213
+ + K+ + K +E S R + Q
Sbjct: 1670 TESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGC 1729
Query: 1214 VLANTHRRLSI--ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAA 1271
V ++S+ +EK++L R + + + ++ EMR Y+ ++ LE A
Sbjct: 1730 VQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR---CQYQERLIKLEHA-EA 1785
Query: 1272 KDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT 1331
K + + L++ +K + + V + ++ ++ + L++
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845
Query: 1332 EAESSAAKLEMAQLKSDLAKL-ENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER-K 1389
E + ++ +L S L + E + + + T+L E +
Sbjct: 1846 ELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTE 1905
Query: 1390 KLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLA 1449
+ + + K + N +A+ L+ KL E+ K I L+++ K+ + L
Sbjct: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELE 1965
Query: 1450 LEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLG 1509
+ K EY++ + E+E + K T+++ + QKE + +T+ +
Sbjct: 1966 ILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQE 2025
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
E+ + + E + + E+ + R LD RE E+ A
Sbjct: 2026 VEAELLESHQEETNQLLKKIAEK--DDDLKRTAKRYEEILDAREEEMTA 2072
Score = 90.6 bits (215), Expect = 5e-17
Identities = 248/1345 (18%), Positives = 513/1345 (38%), Gaps = 100/1345 (7%)
Query: 407 DNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL--EQEKAEHEKKLLEIVG 464
D+ ED SL +E Q I+ R + L K +L + + EKK L+ +
Sbjct: 121 DSEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL 178
Query: 465 GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
+ RI EL +E+ + LQ E + SL + Q +V ++
Sbjct: 179 SQSQDKSLRRIAELREELQMDQQAKKHLQEEF----------DASLEEKDQYISVLQTQV 228
Query: 525 SLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI 584
SL + + P + D L+ L Q AE T K+ NP + D + + ++
Sbjct: 229 SLLKQRLRNGPMNV-----DVLKPLPQLEPQ---AEVFT---KEENPES--DGEPVVEDG 275
Query: 585 VTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN- 643
+ E+ Q ++ K L+ +K + Q L L
Sbjct: 276 TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKD 335
Query: 644 -HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
HMA T R ++ L Q K M R++ T + I ++ T
Sbjct: 336 LHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMT 395
Query: 703 DEADPAEMKLLLELNEQEA-TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+ + E++ E +E+ A L + + ++ +EA +K E+ +I ++ KTS
Sbjct: 396 TQGE--ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERI 453
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKE--RDCERLHAELSLAQKKPKTLIK 819
+ ++ L+ ++ + K E++I +++K L EKE R + L +L +++ + +K
Sbjct: 454 SLQQELSRVKQEVVDVMKKSSEEQIAKLQK-LHEKELARKEQELTKKLQTREREFQEQMK 512
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKNAKSL 877
+L+ S + + + ++ + +QE+ L + LE + + TE NK L + A++
Sbjct: 513 V-ALEKSQSEYLKISQEKE--QQESLAL----EELELQKKAILTESENKLRDLQQEAETY 565
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT---EATKKETDTLK 934
R+ + L+L + LE L+E + K+L + + EK++ T E K E ++LK
Sbjct: 566 RT-RILELESS----LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL--KKM 992
+Q Q ++ L++ ++ + + K ++ +K
Sbjct: 621 HQQDALWTEKLQVLKQQY-----QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT 675
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI 1052
+E L+ + E+ + ++ LS + + A+ KLE+E+ ++ + K E + + +
Sbjct: 676 LEKLDVKQTELESL--SSELS-EVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH- 731
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
+ V++ ++ + KAL+++ + L K + +K +A + L AD+K +
Sbjct: 732 -HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
Query: 1113 -SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIG 1171
LQ + ++ ++ L K+V + +
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
D + + +QL + + + N + + ++ EK+
Sbjct: 851 DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE 910
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKY 1291
+ + + + K I + + K D +HI E + +K
Sbjct: 911 NMILQMREGQKKEIEILTQKLSAKED---------------SIHILNEEYETKFKNQEKK 955
Query: 1292 DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK 1351
E + EL N ++L + E + +A LEMAQ S A
Sbjct: 956 MEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS--AG 1013
Query: 1352 LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL----DRMRIAHDKDVKNKDA 1407
+ + S E +EL+ + KKL + ++ H+ ++ K+
Sbjct: 1014 ISD--AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQE---YEETVKKLEHSLALEKAEYEELTGKYEL 1464
E+A LK K+ + K IT LK+E + T+ +L+ L + A L
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1131
Query: 1465 LE---EEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
L+ E+ V + E Q +L+ ++ ++ L KL T + + K+
Sbjct: 1132 LKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
+ S SL+++ ++ L +LD ++ A + + E +
Sbjct: 1192 HEKSNKSLEDKSL--EFKKLSEELAIQLDICCKKTEALLEAK-TNELINISSSKTNAILS 1248
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA--EITDTKTRYEGQMNT 1639
R +K++ E+ + + T E Q+ +
Sbjct: 1249 RISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKS 1308
Query: 1640 MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRN 1699
M+ +++SL + ++E N +Q + + ++K + S I+ ++ + +E +
Sbjct: 1309 MKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKK-ELSENINAVTLMKEELKEKKV 1367
Query: 1700 KVALLEQQVACLEDELCESRLLASK 1724
+++ L +Q+ L +L S L+ K
Sbjct: 1368 EISSLSKQLTDLNVQLQNSISLSEK 1392
Score = 72.5 bits (170), Expect = 1e-11
Identities = 267/1495 (17%), Positives = 567/1495 (37%), Gaps = 104/1495 (6%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ--QKVNELTTHNEDLRDEKK 341
R+ R++ + S +++D+ + G S + K Q Q++ + R +
Sbjct: 99 RESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYS 158
Query: 342 HLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXX 401
L + ++ E + +Q+ Q + LR AE L EEL + + KK L++
Sbjct: 159 ELVTAYQMLQREKKKLQGILSQS-QDKSLRR---IAE-LREELQMDQQ-AKKHLQEEFDA 212
Query: 402 XXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLE 461
+D + + S L++ L N VL L + E +A+ +E+
Sbjct: 213 SLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPESDGEPV 271
Query: 462 IVGGPDGMQREN---RIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL-MKVPQPE 517
+ G E R+K E + R E + + S+ L ++ + E
Sbjct: 272 VEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELE 331
Query: 518 TVK-VSRSSLTRGGSQ-EDPAQLLRDLQDS-----LEREADLREQLRNAEEETANCKQVN 570
+K + + T+ +Q D L+ L+ E + + E L EEE A +
Sbjct: 332 KIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRI 391
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
+ + + + E + ++ + K + D +I+KT+EE
Sbjct: 392 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 451
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ LS + ++K++ E + +L+K+ K +RK +
Sbjct: 452 RISLQQE-LSRVKQEVVDVMKKSS-------EEQIAKLQKLHEKELARKEQELTKKLQTR 503
Query: 691 IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKIS 750
+ + +++ +K+ E +QE+ L EELE K+A+ LT +
Sbjct: 504 EREFQEQMKVALEKSQSEYLKISQEKEQQESLAL----EELELQKKAI------LTESEN 553
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ + T R L +L K L++ ++ + + E + + + E+++
Sbjct: 554 KLRDLQQEAETYRTRIL-----ELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM 608
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
+K KT ++S QQ+ +LQV++Q+ K + ++ ++K++
Sbjct: 609 VEKHKTELES----LKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF 664
Query: 871 LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
+ + + ++K L+ K T+LE+ L L+++ + ++E S K + T+ K+E
Sbjct: 665 QAHIEEM-NEKTLEKLDVKQTELES-LSSELSEVLKARHKLEEELSVLKDQ-TDKMKQEL 721
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
+ K + Q T K+LKD + + K D K + +
Sbjct: 722 EA-KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL---ELLLKERDKHLK-EHQ 776
Query: 991 KMVEDLECEI----GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKN 1046
VE+LE +I GE+ + +A + K +E ++L + + E+
Sbjct: 777 AHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERI 836
Query: 1047 RLQTEIAKL----KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
L ++A++ KDV +L+ K + + LE +NS + + K+LT+ +++ N
Sbjct: 837 LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN 896
Query: 1103 KLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN--YTKIDQDKNKLL 1160
K K + M M + N Y +++ K +
Sbjct: 897 KEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKM 956
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR 1220
++V K K++ + +++K+L ++ + + +A +
Sbjct: 957 EKVKQKAKEMQETLKKKLLDQEA--KLKKEL---ENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 1221 RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE 1280
+ S + Q I ES E+ D+ + +E K+ + +++H QL+
Sbjct: 1012 AGISDAVSRLETNQKEQI--ESLTEVHRRELNDVISIWEKKLNQQAEEL--QEIHEIQLQ 1067
Query: 1281 DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL 1340
+ ++ K E EM LN + +L++ A ++
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127
Query: 1341 EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK 1400
+ +LK+ L KLE +++ + + EL + +++K+ +
Sbjct: 1128 DETKLKAHLEKLE-------VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT----S 1176
Query: 1401 DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTG 1460
+K D E +LK + + N K + E K+ EE +L+ +A E T
Sbjct: 1177 KLKTTDEEFQSLKSSHE--KSNKSLEDKSL-EFKKLSEELAIQLDICCKKTEALLEAKTN 1233
Query: 1461 KYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKT 1520
EL+ T A L+ Q V++ L + L+ +L + NT
Sbjct: 1234 --ELINISSSKTNAILS-RISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 1521 EMQNSIASLQER---LCGGGWEVERARLNARLDQRE--RELRAANDRRDVLEHHHDXXXX 1575
Q + L+E+ + ++E Q+E + +AA+++ +
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
+ + K++ I SEK +A I+ + +Y+
Sbjct: 1351 NINAVTLMKEELKE-KKVE--ISSLSKQLTDLNVQLQNSISLSEK--EAAISSLRKQYDE 1405
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARI-HRNSISSTDE 1694
+ + D+++ L +V +E+ + + ++ +E K +S H+N++
Sbjct: 1406 EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465
Query: 1695 E-EYRNKVAL-LEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRL 1747
+ E ++K A ++Q+ L++EL + L E+ +KS E + + +++ L
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Score = 61.7 bits (143), Expect = 3e-08
Identities = 221/1317 (16%), Positives = 499/1317 (37%), Gaps = 120/1317 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+DS+ + D + E + L + + KE+ L++RL ++ + G+ SE++
Sbjct: 107 LDSSTASF-DPPSDMDSEAEDLVGNSDSLNKEQ---LIQRLRRMERSLSSYRGKYSELVT 162
Query: 322 LQQKVNELTTHNEDLRDEKKHLT-QKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
Q + + + + + + ++I E+ EL+ +A+ E+ A L +
Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQM--DQQAKKHLQEEFDASLEEKDQY 220
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR-EDQADEYSSLRR---------ELEQTIKN 430
L + +K+ LR+ ++ + E QA+ ++ E ++K
Sbjct: 221 ISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKT 280
Query: 431 CRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRE--NRIKELEQ----EVAR 484
L ++K+ E + ++ H+++ + + +Q + R++ELE+ +A
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 485 STEVALRLQ--RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ----EDPAQL 538
T++ +L+ + L E + G + K ET+++ + + S+ +
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 539 LRDLQDSLEREA--DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
LR+ ++ ER A +L + L A++ +++ +D+Q+ T + E E ++
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE--MDEQIKTIEKTS----EEERIS 454
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAAR 656
+ + K+ S+ + K E+ + +
Sbjct: 455 LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVA 514
Query: 657 VEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
+E+ ++S L++ + + S L K +I T ++N ++ + +LEL
Sbjct: 515 LEK-SQSEYLKISQEKEQQESLALEELE-LQKKAILTESENKLRDLQQEAETYRTRILEL 572
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
L + ++E + + L ++ +K + + T SL + L
Sbjct: 573 ESS----LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
Query: 777 ERVKVLEDEIDEVRKKLIEK-ERDCERLHAELSLA------QKKPKTL----IKSRSLDA 825
E+++VL+ + +KL EK E++ E L + + + KTL +K L++
Sbjct: 629 EKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES 688
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL 885
+ ++ + +E+E SVL+ +T ++ + E K+ KN + D +
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELE------AKMDEQKNHHQQQVDSIIKE 742
Query: 886 NTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXX 945
+ + E LK+ +I +LE++ ++ K E D +S+
Sbjct: 743 HEVSIQRTEKALKD---QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL-TTKLQLKKMVEDLECEIGEMY 1004
+ T A + ++ +K DL T ++ L K V ++E +
Sbjct: 800 LDVFQSYQSATHEQT------KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ----- 848
Query: 1005 VVMKNAGLSGKEMTAKTKLEK-EIDEIRSKLSKNDSEFTNE-KNRLQTEIAKLKDVNAKL 1062
K++ + K ++ ++ +L K +SE + K+ Q +KL+D N +
Sbjct: 849 ---------KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ 899
Query: 1063 EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCM 1122
E K + K + + + LT+++ +E I+ L+ + + Q + +
Sbjct: 900 EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKV 959
Query: 1123 XXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD--XXXXXXXX 1180
+D K+ ++ E+ K K+
Sbjct: 960 KQKAKEMQETLKKKL--------LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
+ + + +K+++ + + E E E+Q + +
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 1241 ESKFITLEAEMRDLKADYENK-ITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVE 1299
E + + + + + NK IT L+ +D + +L++ L+Q + A +
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1131
Query: 1300 MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXX 1359
+ + +LN K E T + +L+M + D K+
Sbjct: 1132 L----------KAHLEKLEVDLN--KSLKENTFLQEQLVELKML-AEEDKRKVSELTSKL 1178
Query: 1360 XXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKIL 1419
S E K L+ D E KKL +A D+ K E A L+ K L
Sbjct: 1179 KTTDEEFQSLKSSHEKSNKSLE-DKSLEFKKLSE-ELAIQLDICCKKTE-ALLEAKTNEL 1235
Query: 1420 EQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKY-ELLEEEHV--VTKARL 1476
S + I + K++ +L ++ EL + +L EE++ ++ +
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
T + E+ + ++ ++ ++ + + E + LQ++ G + A +E ++ I L++ L
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQA----ASEKESCITQLKKEL 1348
Score = 51.6 bits (118), Expect = 3e-05
Identities = 123/618 (19%), Positives = 241/618 (38%), Gaps = 61/618 (9%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D+ VKE +++I L+ +V ++ E +KE + L + + SE
Sbjct: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAA- 1635
Query: 323 QQKVNELTTHNED-LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET-- 379
K+ EL E + KK L ++ E E + + TE+ + +L KL E
Sbjct: 1636 --KLAELKRKAEQKIAAIKKQLLSQMEEKEEQY--KKGTESH---LSELNTKLQEREREV 1688
Query: 380 -LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ EE + E + E + + +++AD +++ E+ I VL L
Sbjct: 1689 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS---VLQRNL 1745
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTE---VALRLQRE 495
+ E+ ++ QEK E E+ Q + R+ +LE A+ E + LQ E
Sbjct: 1746 TEKEKLLQRVGQEKEETVSSHFEM-----RCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
L E N K++ + V Q + ++++ ++++ + D+Q +L+ + +
Sbjct: 1801 LEEKNKKYS------LIVAQHVEKEGGKNNIQ---AKQNLENVFDDVQKTLQEKELTCQI 1851
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
L +E +C L +Q + E E +T+ + + A + K
Sbjct: 1852 LEQKIKELDSC--------LVRQKEVHRV------EMEELTSKYEK--LQALQQMDGRNK 1895
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
L + T E+++ H P L N+L A E + + L ++ ++
Sbjct: 1896 PTE--LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL 1953
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK---LLLELNEQEATVLRRKVEELE 732
R + L E + +EK E + E+K L +L + T L +K +ELE
Sbjct: 1954 RMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELE 2013
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
+K+ + + + + ++ + + + L + K E+ +D ++
Sbjct: 2014 M---TIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDL-KRTAKRYEEILDAREEE 2069
Query: 793 LIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-DLKRQLQVIEQEASVLRAKT 851
+ K RD L +L QKK + ++ +D + +L+ QL S + K
Sbjct: 2070 MTAKVRD---LQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE 2126
Query: 852 QSLEADNEKLQTENKKLQ 869
Q L+ KK +
Sbjct: 2127 QEFREQIHNLEDRLKKYE 2144
Score = 42.3 bits (95), Expect = 0.017
Identities = 41/182 (22%), Positives = 87/182 (47%), Gaps = 17/182 (9%)
Query: 1615 IEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAE 1674
IEQ E+ + I +TK + + +E+ L +++ + + + ++ E +++ A
Sbjct: 355 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER--AA 412
Query: 1675 IKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLL----ASKLNTELV 1730
+ +K+ S + EE R A +++Q+ +E E R+ S++ E+V
Sbjct: 413 FEELEKAL-----STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV 467
Query: 1731 S-EKSSAEVRLAEMQSRLNEYE----EERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
K S+E ++A++Q +L+E E E+ L + R +M++A K + E ++
Sbjct: 468 DVMKKSSEEQIAKLQ-KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526
Query: 1786 QE 1787
QE
Sbjct: 527 QE 528
>U41740-1|AAC50434.1| 2230|Homo sapiens trans-Golgi p230 protein.
Length = 2230
Score = 103 bits (247), Expect = 6e-21
Identities = 271/1333 (20%), Positives = 507/1333 (38%), Gaps = 123/1333 (9%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
+ + + Q ++ L+ E +L K+ VE +K D+ A+ + ++
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 323 QQKVNELT-THNEDLRDEKKHLTQ-KIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+QKV LT + L D K Q K +E E E Q ++IE L KL A E
Sbjct: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
Query: 381 CEELMDENE----DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK------- 429
L +E E + +K++ + MQ+ ++ D+ + L++ELE T
Sbjct: 938 IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997
Query: 430 --NCRVLSFKLKKTERKAD---QLEQEKAEHEKKLLEIVGGP--DGMQ-RENRIKELEQE 481
N ++L + +D +LE + E + L E+ D + E ++ + +E
Sbjct: 998 QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE 1057
Query: 482 VARSTEVALR-LQRELAEANSK---FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ 537
+ E+ L+ ++E+AE K F + K + + T QE Q
Sbjct: 1058 LQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQ 1117
Query: 538 LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQ-VMTDNIVTCDIHESETVT 596
+ + E L+ L E + K + TFL +Q V + D + +T
Sbjct: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLN--KSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175
Query: 597 NSIQNKMIHAASTPSSKEKS----DSPPLSIDKTTEETQFHFDL--PYLSIFNHMAANNL 650
+ ++ S SS EKS + L K +EE D+ N L
Sbjct: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL 1235
Query: 651 RKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
++ S + + TK + L T ++L + +E+ T +
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
LE E + ++ +E L +KEAL+K+ S K S + S N
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE--KESCITQLKKELSENIN 1353
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
+ L +E +K + EI + K+L + +L +SL++K+ S D++
Sbjct: 1354 AVTLMKEELKEKKVEISSLSKQLTDLN---VQLQNSISLSEKEAAI---SSLRKQYDEEK 1407
Query: 831 VDLKRQLQVIEQEASVL-RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+L Q+Q + + L + K +LE ++ NK + K A+S + NT K
Sbjct: 1408 CELLDQVQDLSFKVDTLSKEKISALEQVDD---WSNKFSEWKKKAQSRFTQHQ---NTVK 1461
Query: 890 TTQLENEL--KEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS---KQXXXXXXX 944
Q++ EL KEA K +++ ++ ++E ++ RF + K E + KS K+
Sbjct: 1462 ELQIQLELKSKEAYEKDEQINLL-KEELDQQNKRF-DCLKGEMEDDKSKMEKKESNLETE 1519
Query: 945 XXXXXXXXXXXXXQATLKSLK----DDAQKSFKPRIPKKPTDLTTKLQ-LKKMVEDLECE 999
T K+++ ++ K++ + + +L KLQ +++ E+ +
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLE---KEIDEIRSKLSKNDSEFTNEKNRLQTE-IAKL 1055
+ E K L + + K +LE KE++ + + + E ++RL++E AKL
Sbjct: 1580 VKE--AEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKL 1637
Query: 1056 KDVNAKLEG-----DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
++ K E K + + + E + L +++ RE +++ L LK+
Sbjct: 1638 AELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697
Query: 1111 ATSLQT-TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQ----DKNKLLKEVGD 1165
S Q+ T+ + + Q +K KLL+ VG
Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ 1757
Query: 1166 KTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-- 1223
+ ++ C+ E+ + Q L +++ S
Sbjct: 1758 EKEE-----TVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE-ELEEKNKKYSLI 1811
Query: 1224 ----IELTSEKDELQARFIKTESKFITLEAEMRDLKAD---YENKITSLES-TIAAKDVH 1275
+E K+ +QA+ E+ F ++ +++ + E KI L+S + K+VH
Sbjct: 1812 VAQHVEKEGGKNNIQAK-QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Query: 1276 IKQLEDALRQTTN----DKYDEATSPVEMVEMRXXXXXXX-----XXXXXXQDELNNAKI 1326
++E+ + + D P E++E + + N+ +
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEF 1930
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQ- 1385
KL E E E+ +L+ DL L E K K+ DL+
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQER--EEKIKQEQEDLEL 1988
Query: 1386 SERKKLDRMRIAHDKDVKNKDAEL-ATLKGKL--------KILE---QNSGAGAKRITEL 1433
L ++ + + K+ EL T+K + ++LE + + K+I E
Sbjct: 1989 KHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK 2048
Query: 1434 KQEYEETVKKLEHSLALEKAEYEELTGKYELLEE--EHVVTKARLTVEKEQAQGELLHVQ 1491
+ + T K+ E L A EE+T K L+ E + K + +E+E+ G
Sbjct: 2049 DDDLKRTAKRYEEIL---DAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTI 2105
Query: 1492 KELSTALGEIKTL 1504
EL T L + TL
Sbjct: 2106 MELQTQLAQKTTL 2118
Score = 95.5 bits (227), Expect = 2e-18
Identities = 278/1489 (18%), Positives = 576/1489 (38%), Gaps = 113/1489 (7%)
Query: 154 QTQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEK-ERERRSLSKSKEDEKTARYKD-- 210
+T+L K+ A K+Q+LK Q E E EK E+E+ +L K KE A ++
Sbjct: 613 KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 672
Query: 211 ERSSTKDDVNFL-MQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEY 269
E++ K DV ++ +S S LK + +D +
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 732
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKS---DILLRR-----------LANIDTANKYTTG- 314
Q Q++ + +E ++ +R E+ K++ ++LL+ + N++ K + G
Sbjct: 733 QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792
Query: 315 --RSSEVLKLQQKVNELTTHNEDLRDEK-KHLTQKIREIESE--LETRP--STEAQTRQI 367
++S L + Q T +E+ L QK+ ++E+E L T+ EAQ + +
Sbjct: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852
Query: 368 -EQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXX-MQDNFREDQADEYSSLRRE-- 423
+L A + + L ++L +N +M+++++ L ++D +E + + + +E
Sbjct: 853 CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM 912
Query: 424 ----LEQTIKNCRVLSFKLKKTERKADQLEQEKA----EHEKKLLEIVGGPDGMQRENRI 475
E K +L+ KL E L +E EKK+ ++ MQ +
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Query: 476 KELEQEVARSTEV---ALRLQR----------ELAEANSKFTGSNPSLMKVPQPETVKVS 522
K L+QE E+ AL L + E+A+ANS S ++ Q E ++ S
Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE-S 1031
Query: 523 RSSLTRGGSQEDPAQLLRDLQDSLEREADLRE-QLRNAEEETANCKQVNPPTFLDKQVMT 581
+ + R + + + L E ++ E QL+ E+E A KQ +K+ M
Sbjct: 1032 LTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMN 1091
Query: 582 DNIVTCDIH--ESETVTNSIQNKM------IHAASTPSSKEKSDSPPLSID--KTTEETQ 631
I + +T N +Q ++ +++ + +K K+ L +D K+ +E
Sbjct: 1092 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
Query: 632 FH----FDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN 687
F +L L+ + + L +E+ +SL +K + L +
Sbjct: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
Query: 688 KLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTS 747
+L+I+ D K+T+ A+ L+ ++ + + ++ + +K+ L
Sbjct: 1212 ELAIQL--DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEA---LLI 1266
Query: 748 KISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
K +V++ A R LT N L + +++E ++ + D E L E
Sbjct: 1267 KTCTVSELEA-----QLRQLTEEQNTL-NISFQQATHQLEEKENQIKSMKADIESLVTEK 1320
Query: 808 SLAQKKPKTLIKSRSLDAS--DQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
QK+ ++ S S Q +L + + L+ K + + +++L N
Sbjct: 1321 EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN 1380
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEA 925
+LQ N+ SL +A + +K Q + E E L ++++L D S++K+ E
Sbjct: 1381 VQLQ---NSISLSEKEAAISSLRK--QYDEEKCELLDQVQDLSFKV-DTLSKEKISALEQ 1434
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT 985
++ S+ Q LKS K+ +K + + K+ D
Sbjct: 1435 VDDWSNKF-SEWKKKAQSRFTQHQNTVKELQIQLELKS-KEAYEKDEQINLLKEELDQQN 1492
Query: 986 KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK 1045
K + + ++E + +M N K TA+ +E E D I K + +S K
Sbjct: 1493 K-RFDCLKGEMEDDKSKMEKKESNLETELKSQTARI-MELE-DHITQKTIEIESLNEVLK 1549
Query: 1046 NRLQTEIAKLKDVNAKLEGDKDVFA---NKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
N Q + + K++ KL+ +++ N+ K E + L NQ ++ E++ ++ ++
Sbjct: 1550 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE 1609
Query: 1103 KLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLK- 1161
++ +K+ + D + + +++++ + + K
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1669
Query: 1162 ---EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLST-----RKDRVTXXXXXXXXXXXQAV 1213
+ + K+ + K +E S R + Q
Sbjct: 1670 TESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGC 1729
Query: 1214 VLANTHRRLSI--ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAA 1271
V ++S+ +EK++L R + + + ++ EMR Y+ ++ LE A
Sbjct: 1730 VQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR---CQYQERLIKLEHA-EA 1785
Query: 1272 KDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT 1331
K + + L++ +K + + V + ++ ++ + L++
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845
Query: 1332 EAESSAAKLEMAQLKSDLAKL-ENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER-K 1389
E + ++ +L S L + E + + + T+L E +
Sbjct: 1846 ELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTE 1905
Query: 1390 KLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLA 1449
+ + + K + N +A+ L+ KL E+ K I L+++ K+ + L
Sbjct: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELE 1965
Query: 1450 LEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLG 1509
+ K EY++ + E+E + K T+++ + QKE + +T+ +
Sbjct: 1966 ILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQE 2025
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
E+ + + E + + E+ + R LD RE E+ A
Sbjct: 2026 VEAELLESHQEETNQLLKKIAEK--DDDLKRTAKRYEEILDAREEEMTA 2072
Score = 90.6 bits (215), Expect = 5e-17
Identities = 248/1345 (18%), Positives = 513/1345 (38%), Gaps = 100/1345 (7%)
Query: 407 DNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL--EQEKAEHEKKLLEIVG 464
D+ ED SL +E Q I+ R + L K +L + + EKK L+ +
Sbjct: 121 DSEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL 178
Query: 465 GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
+ RI EL +E+ + LQ E + SL + Q +V ++
Sbjct: 179 SQSQDKSLRRIAELREELQMDQQAKKHLQEEF----------DASLEEKDQYISVLQTQV 228
Query: 525 SLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI 584
SL + + P + D L+ L Q AE T K+ NP + D + + ++
Sbjct: 229 SLLKQRLRNGPMNV-----DVLKPLPQLEPQ---AEVFT---KEENPES--DGEPVVEDG 275
Query: 585 VTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN- 643
+ E+ Q ++ K L+ +K + Q L L
Sbjct: 276 TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKD 335
Query: 644 -HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
HMA T R ++ L Q K M R++ T + I ++ T
Sbjct: 336 LHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMT 395
Query: 703 DEADPAEMKLLLELNEQEA-TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+ + E++ E +E+ A L + + ++ +EA +K E+ +I ++ KTS
Sbjct: 396 TQGE--ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERI 453
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKE--RDCERLHAELSLAQKKPKTLIK 819
+ ++ L+ ++ + K E++I +++K L EKE R + L +L +++ + +K
Sbjct: 454 SLQQELSRVKQEVVDVMKKSSEEQIAKLQK-LHEKELARKEQELTKKLQTREREFQEQMK 512
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKNAKSL 877
+L+ S + + + ++ + +QE+ L + LE + + TE NK L + A++
Sbjct: 513 V-ALEKSQSEYLKISQEKE--QQESLAL----EELELQKKAILTESENKLRDLQQEAETY 565
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT---EATKKETDTLK 934
R+ + L+L + LE L+E + K+L + + EK++ T E K E ++LK
Sbjct: 566 RT-RILELESS----LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL--KKM 992
+Q Q ++ L++ ++ + + K ++ +K
Sbjct: 621 HQQDALWTEKLQVLKQQY-----QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT 675
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI 1052
+E L+ + E+ + ++ LS + + A+ KLE+E+ ++ + K E + + +
Sbjct: 676 LEKLDVKQTELESL--SSELS-EVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH- 731
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
+ V++ ++ + KAL+++ + L K + +K +A + L AD+K +
Sbjct: 732 -HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
Query: 1113 -SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIG 1171
LQ + ++ ++ L K+V + +
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
D + + +QL + + + N + + ++ EK+
Sbjct: 851 DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE 910
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKY 1291
+ + + + K I + + K D +HI E + +K
Sbjct: 911 NMILQMREGQKKEIEILTQKLSAKED---------------SIHILNEEYETKFKNQEKK 955
Query: 1292 DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK 1351
E + EL N ++L + E + +A LEMAQ S A
Sbjct: 956 MEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS--AG 1013
Query: 1352 LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL----DRMRIAHDKDVKNKDA 1407
+ + S E +EL+ + KKL + ++ H+ ++ K+
Sbjct: 1014 ISD--AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQE---YEETVKKLEHSLALEKAEYEELTGKYEL 1464
E+A LK K+ + K IT LK+E + T+ +L+ L + A L
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1131
Query: 1465 LE---EEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
L+ E+ V + E Q +L+ ++ ++ L KL T + + K+
Sbjct: 1132 LKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
+ S SL+++ ++ L +LD ++ A + + E +
Sbjct: 1192 HEKSNKSLEDKSL--EFKKLSEELAIQLDICCKKTEALLEAK-TNELINISSSKTNAILS 1248
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA--EITDTKTRYEGQMNT 1639
R +K++ E+ + + T E Q+ +
Sbjct: 1249 RISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKS 1308
Query: 1640 MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRN 1699
M+ +++SL + ++E N +Q + + ++K + S I+ ++ + +E +
Sbjct: 1309 MKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKK-ELSENINAVTLMKEELKEKKV 1367
Query: 1700 KVALLEQQVACLEDELCESRLLASK 1724
+++ L +Q+ L +L S L+ K
Sbjct: 1368 EISSLSKQLTDLNVQLQNSISLSEK 1392
Score = 72.5 bits (170), Expect = 1e-11
Identities = 267/1495 (17%), Positives = 567/1495 (37%), Gaps = 104/1495 (6%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ--QKVNELTTHNEDLRDEKK 341
R+ R++ + S +++D+ + G S + K Q Q++ + R +
Sbjct: 99 RESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYS 158
Query: 342 HLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXX 401
L + ++ E + +Q+ Q + LR AE L EEL + + KK L++
Sbjct: 159 ELVTAYQMLQREKKKLQGILSQS-QDKSLRR---IAE-LREELQMDQQ-AKKHLQEEFDA 212
Query: 402 XXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLE 461
+D + + S L++ L N VL L + E +A+ +E+
Sbjct: 213 SLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPESDGEPV 271
Query: 462 IVGGPDGMQREN---RIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL-MKVPQPE 517
+ G E R+K E + R E + + S+ L ++ + E
Sbjct: 272 VEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELE 331
Query: 518 TVK-VSRSSLTRGGSQ-EDPAQLLRDLQDS-----LEREADLREQLRNAEEETANCKQVN 570
+K + + T+ +Q D L+ L+ E + + E L EEE A +
Sbjct: 332 KIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRI 391
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
+ + + + E + ++ + K + D +I+KT+EE
Sbjct: 392 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 451
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ LS + ++K++ E + +L+K+ K +RK +
Sbjct: 452 RISLQQE-LSRVKQEVVDVMKKSS-------EEQIAKLQKLHEKELARKEQELTKKLQTR 503
Query: 691 IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKIS 750
+ + +++ +K+ E +QE+ L EELE K+A+ LT +
Sbjct: 504 EREFQEQMKVALEKSQSEYLKISQEKEQQESLAL----EELELQKKAI------LTESEN 553
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ + T R L +L K L++ ++ + + E + + + E+++
Sbjct: 554 KLRDLQQEAETYRTRIL-----ELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM 608
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
+K KT ++S QQ+ +LQV++Q+ K + ++ ++K++
Sbjct: 609 VEKHKTELES----LKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF 664
Query: 871 LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
+ + + ++K L+ K T+LE+ L L+++ + ++E S K + T+ K+E
Sbjct: 665 QAHIEEM-NEKTLEKLDVKQTELES-LSSELSEVLKARHKLEEELSVLKDQ-TDKMKQEL 721
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
+ K + Q T K+LKD + + K D K + +
Sbjct: 722 EA-KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL---ELLLKERDKHLK-EHQ 776
Query: 991 KMVEDLECEI----GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKN 1046
VE+LE +I GE+ + +A + K +E ++L + + E+
Sbjct: 777 AHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERI 836
Query: 1047 RLQTEIAKL----KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
L ++A++ KDV +L+ K + + LE +NS + + K+LT+ +++ N
Sbjct: 837 LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN 896
Query: 1103 KLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN--YTKIDQDKNKLL 1160
K K + M M + N Y +++ K +
Sbjct: 897 KEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKM 956
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR 1220
++V K K++ + +++K+L ++ + + +A +
Sbjct: 957 EKVKQKAKEMQETLKKKLLDQEA--KLKKEL---ENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 1221 RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE 1280
+ S + Q I ES E+ D+ + +E K+ + +++H QL+
Sbjct: 1012 AGISDAVSRLETNQKEQI--ESLTEVHRRELNDVISIWEKKLNQQAEEL--QEIHEIQLQ 1067
Query: 1281 DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL 1340
+ ++ K E EM LN + +L++ A ++
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127
Query: 1341 EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK 1400
+ +LK+ L KLE +++ + + EL + +++K+ +
Sbjct: 1128 DETKLKAHLEKLE-------VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT----S 1176
Query: 1401 DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTG 1460
+K D E +LK + + N K + E K+ EE +L+ +A E T
Sbjct: 1177 KLKTTDEEFQSLKSSHE--KSNKSLEDKSL-EFKKLSEELAIQLDICCKKTEALLEAKTN 1233
Query: 1461 KYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKT 1520
EL+ T A L+ Q V++ L + L+ +L + NT
Sbjct: 1234 --ELINISSSKTNAILS-RISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 1521 EMQNSIASLQER---LCGGGWEVERARLNARLDQRE--RELRAANDRRDVLEHHHDXXXX 1575
Q + L+E+ + ++E Q+E + +AA+++ +
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
+ + K++ I SEK +A I+ + +Y+
Sbjct: 1351 NINAVTLMKEELKE-KKVE--ISSLSKQLTDLNVQLQNSISLSEK--EAAISSLRKQYDE 1405
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARI-HRNSISSTDE 1694
+ + D+++ L +V +E+ + + ++ +E K +S H+N++
Sbjct: 1406 EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465
Query: 1695 E-EYRNKVAL-LEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRL 1747
+ E ++K A ++Q+ L++EL + L E+ +KS E + + +++ L
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Score = 61.7 bits (143), Expect = 3e-08
Identities = 221/1317 (16%), Positives = 499/1317 (37%), Gaps = 120/1317 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+DS+ + D + E + L + + KE+ L++RL ++ + G+ SE++
Sbjct: 107 LDSSTASF-DPPSDMDSEAEDLVGNSDSLNKEQ---LIQRLRRMERSLSSYRGKYSELVT 162
Query: 322 LQQKVNELTTHNEDLRDEKKHLT-QKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
Q + + + + + + ++I E+ EL+ +A+ E+ A L +
Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQM--DQQAKKHLQEEFDASLEEKDQY 220
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR-EDQADEYSSLRR---------ELEQTIKN 430
L + +K+ LR+ ++ + E QA+ ++ E ++K
Sbjct: 221 ISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKT 280
Query: 431 CRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRE--NRIKELEQ----EVAR 484
L ++K+ E + ++ H+++ + + +Q + R++ELE+ +A
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 485 STEVALRLQ--RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ----EDPAQL 538
T++ +L+ + L E + G + K ET+++ + + S+ +
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 539 LRDLQDSLEREA--DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
LR+ ++ ER A +L + L A++ +++ +D+Q+ T + E E ++
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE--MDEQIKTIEKTS----EEERIS 454
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAAR 656
+ + K+ S+ + K E+ + +
Sbjct: 455 LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVA 514
Query: 657 VEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
+E+ ++S L++ + + S L K +I T ++N ++ + +LEL
Sbjct: 515 LEK-SQSEYLKISQEKEQQESLALEELE-LQKKAILTESENKLRDLQQEAETYRTRILEL 572
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
L + ++E + + L ++ +K + + T SL + L
Sbjct: 573 ESS----LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628
Query: 777 ERVKVLEDEIDEVRKKLIEK-ERDCERLHAELSLA------QKKPKTL----IKSRSLDA 825
E+++VL+ + +KL EK E++ E L + + + KTL +K L++
Sbjct: 629 EKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES 688
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL 885
+ ++ + +E+E SVL+ +T ++ + E K+ KN + D +
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELE------AKMDEQKNHHQQQVDSIIKE 742
Query: 886 NTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXX 945
+ + E LK+ +I +LE++ ++ K E D +S+
Sbjct: 743 HEVSIQRTEKALKD---QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL-TTKLQLKKMVEDLECEIGEMY 1004
+ T A + ++ +K DL T ++ L K V ++E +
Sbjct: 800 LDVFQSYQSATHEQT------KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ----- 848
Query: 1005 VVMKNAGLSGKEMTAKTKLEK-EIDEIRSKLSKNDSEFTNE-KNRLQTEIAKLKDVNAKL 1062
K++ + K ++ ++ +L K +SE + K+ Q +KL+D N +
Sbjct: 849 ---------KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ 899
Query: 1063 EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCM 1122
E K + K + + + LT+++ +E I+ L+ + + Q + +
Sbjct: 900 EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKV 959
Query: 1123 XXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD--XXXXXXXX 1180
+D K+ ++ E+ K K+
Sbjct: 960 KQKAKEMQETLKKKL--------LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
+ + + +K+++ + + E E E+Q + +
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 1241 ESKFITLEAEMRDLKADYENK-ITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVE 1299
E + + + + + NK IT L+ +D + +L++ L+Q + A +
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1131
Query: 1300 MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXX 1359
+ + +LN K E T + +L+M + D K+
Sbjct: 1132 L----------KAHLEKLEVDLN--KSLKENTFLQEQLVELKML-AEEDKRKVSELTSKL 1178
Query: 1360 XXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKIL 1419
S E K L+ D E KKL +A D+ K E A L+ K L
Sbjct: 1179 KTTDEEFQSLKSSHEKSNKSLE-DKSLEFKKLSE-ELAIQLDICCKKTE-ALLEAKTNEL 1235
Query: 1420 EQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKY-ELLEEEHV--VTKARL 1476
S + I + K++ +L ++ EL + +L EE++ ++ +
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
T + E+ + ++ ++ ++ + + E + LQ++ G + A +E ++ I L++ L
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQA----ASEKESCITQLKKEL 1348
Score = 51.6 bits (118), Expect = 3e-05
Identities = 123/618 (19%), Positives = 241/618 (38%), Gaps = 61/618 (9%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D+ VKE +++I L+ +V ++ E +KE + L + + SE
Sbjct: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAA- 1635
Query: 323 QQKVNELTTHNED-LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET-- 379
K+ EL E + KK L ++ E E + + TE+ + +L KL E
Sbjct: 1636 --KLAELKRKAEQKIAAIKKQLLSQMEEKEEQY--KKGTESH---LSELNTKLQEREREV 1688
Query: 380 -LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ EE + E + E + + +++AD +++ E+ I VL L
Sbjct: 1689 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS---VLQRNL 1745
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTE---VALRLQRE 495
+ E+ ++ QEK E E+ Q + R+ +LE A+ E + LQ E
Sbjct: 1746 TEKEKLLQRVGQEKEETVSSHFEM-----RCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
L E N K++ + V Q + ++++ ++++ + D+Q +L+ + +
Sbjct: 1801 LEEKNKKYS------LIVAQHVEKEGGKNNIQ---AKQNLENVFDDVQKTLQEKELTCQI 1851
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
L +E +C L +Q + E E +T+ + + A + K
Sbjct: 1852 LEQKIKELDSC--------LVRQKEVHRV------EMEELTSKYEK--LQALQQMDGRNK 1895
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
L + T E+++ H P L N+L A E + + L ++ ++
Sbjct: 1896 PTE--LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL 1953
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK---LLLELNEQEATVLRRKVEELE 732
R + L E + +EK E + E+K L +L + T L +K +ELE
Sbjct: 1954 RMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELE 2013
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
+K+ + + + + ++ + + + L + K E+ +D ++
Sbjct: 2014 M---TIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDL-KRTAKRYEEILDAREEE 2069
Query: 793 LIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-DLKRQLQVIEQEASVLRAKT 851
+ K RD L +L QKK + ++ +D + +L+ QL S + K
Sbjct: 2070 MTAKVRD---LQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE 2126
Query: 852 QSLEADNEKLQTENKKLQ 869
Q L+ KK +
Sbjct: 2127 QEFREQIHNLEDRLKKYE 2144
Score = 42.3 bits (95), Expect = 0.017
Identities = 41/182 (22%), Positives = 87/182 (47%), Gaps = 17/182 (9%)
Query: 1615 IEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAE 1674
IEQ E+ + I +TK + + +E+ L +++ + + + ++ E +++ A
Sbjct: 355 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER--AA 412
Query: 1675 IKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLL----ASKLNTELV 1730
+ +K+ S + EE R A +++Q+ +E E R+ S++ E+V
Sbjct: 413 FEELEKAL-----STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV 467
Query: 1731 S-EKSSAEVRLAEMQSRLNEYE----EERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
K S+E ++A++Q +L+E E E+ L + R +M++A K + E ++
Sbjct: 468 DVMKKSSEEQIAKLQ-KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526
Query: 1786 QE 1787
QE
Sbjct: 527 QE 528
>M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle
myosin heavy chain (NMHC) mRNA, 3' end. ).
Length = 1247
Score = 103 bits (246), Expect = 9e-21
Identities = 188/869 (21%), Positives = 361/869 (41%), Gaps = 73/869 (8%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
++++E + E +QE++ R++ E + SD + A I + E+
Sbjct: 316 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL 375
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELET-RPSTEAQTRQIEQLRAKLLAAETLCE 382
+V E + + L +I E++ +LE+ R S +Q L +L A +T E
Sbjct: 376 ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 435
Query: 383 ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKLKKT 441
+ +D ++ELR + E++A + + +E+ Q L+ +L++T
Sbjct: 436 DTLDSTA-AQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQT 494
Query: 442 ER------KADQ-LEQEKAE--HEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
+R KA Q LE E+ E +E K+L + GG D + +++ QE+ R+
Sbjct: 495 KRVKANLEKAKQTLENERGELANEVKVL-LQGGRDSEHKRKKVEAQLQELQVKFNEGERV 553
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+ ELA+ K T L V T +S+S +D + L LQD+ E L
Sbjct: 554 RTELAD---KVTKLQVELDNV----TGLLSQSDSKSSKLTKDFSALESQLQDTQEL---L 603
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAASTP 610
+E+ R + KQV +K + + E E ++++ ++ +HA
Sbjct: 604 QEENRQKLSLSTKLKQVED----EKNSFREQLE----EEEEEAKHNLEKQIATLHAQVAD 655
Query: 611 SSKEKSDSPPLSIDKTTEETQ--FHFDLPYLSIFNH---MAANNLRKTAARVEEDNESLL 665
K+ DS + +T EE + DL LS + A + L KT R++++ + LL
Sbjct: 656 MKKKMEDS--VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 713
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
+ L A + + L+ E K +E D AE + E +A L
Sbjct: 714 VDLDHQRQSACNLEKKQKKFDQLLAEEKTIS--AKYAEERDRAEAEA--REKETKALSLA 769
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
R +EE + K L++ K+ +++ + + + S + E++V+ ++ +
Sbjct: 770 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE--LEKSKRALEQQVEEMKTQ 827
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
++E+ +L E RL L + + + ++ R + S+++ L RQ++ +E E
Sbjct: 828 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRD-EQSEEKKKQLVRQVREMEAELE 886
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
R + A +KL+ + K L+ ++ + D+A+ K+ +L+ ++K+ + +
Sbjct: 887 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI----KQLRKLQAQMKDCM---R 939
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
EL+ D ++ ++ +A + E LKS + Q L
Sbjct: 940 ELD----DTRASREEILAQAKENEKK-LKSMEAEMIQLQEELAAAERAKRQAQQERDELA 994
Query: 966 DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
D+ S K L K +L+ + LE E+ E N L + K
Sbjct: 995 DEIANSSG----KGALALEEKRRLEARIAQLEEELEEE---QGNTELINDRLK---KANL 1044
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK----ALENENS 1081
+ID+I + L+ +N Q + K++ KL+ + +KYK ALE + +
Sbjct: 1045 QIDQINADLNLERGHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1104
Query: 1082 NLSNQCKTLTEEMKNREAQINKLSADLKN 1110
L Q T+E + Q+ + LK+
Sbjct: 1105 QLEEQLDNETKERQAACKQVRRTEKKLKD 1133
Score = 92.7 bits (220), Expect = 1e-17
Identities = 216/1145 (18%), Positives = 437/1145 (38%), Gaps = 90/1145 (7%)
Query: 277 KQEVDILRKRCERVE-KEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+QE +++ K E V+ +EK RL ++T ++ + Q EL E+
Sbjct: 128 RQEEEMMAKEEELVKVREKQLAAENRLMEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 187
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL-CEELMDENEDMKKE 394
LR Q++ EI +LE R E + Q Q K + EE ++E E +++
Sbjct: 188 LRARLTAKKQELEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQELEEQLEEEESARQK 247
Query: 395 LRDLXXXXXXMQDNFREDQ---ADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
L+ E+Q D+ L +E + + L + E K+ L +
Sbjct: 248 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 307
Query: 452 KAEHEKKLLEIVGGPDGMQRENRIK-ELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
K +HE + ++ + ++RE + + ELE+ + + L ++AE ++ L
Sbjct: 308 KNKHEAMITDL---EERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 364
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
K + ++R +E+ AQ L+ E E+ + E + E E A+ +
Sbjct: 365 AKKEEELQAALAR-------VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA- 416
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
+KQ E E + +++ + A+ + K + + KT EE
Sbjct: 417 -----EKQKRDLG------EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 465
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ + + + + A ++E+ + + L+K A + + K+
Sbjct: 466 AKTHE-AQIQEMRQKHSQAVEELAEQLEQ-TKRVKANLEK-AKQTLENERGELANEVKVL 522
Query: 691 IETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKI 749
++ D++ K EA E+++ E+ T L KV +L+ + + + + + SK
Sbjct: 523 LQGGRDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 582
Query: 750 SSVTKTSAGSNT----TARRSLTTNSNKLA-EERVKVLEDEIDEVRKKLIEKERDCER-- 802
S +TK + + T N KL+ ++K +EDE + R++L E+E + +
Sbjct: 583 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEEAKHNL 642
Query: 803 ------LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
LHA+++ +KK + + L+ +++ L++ L+ + Q A LE
Sbjct: 643 EKQIATLHAQVADMKKKMEDSV--GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 700
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
+LQ E L L+ +S L+ KK QL E K AK E + E
Sbjct: 701 TKTRLQQELDDL-LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 759
Query: 917 EKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRI 976
EK+ + + + ++ K L S KDD KS +
Sbjct: 760 EKETKALSLARALEEAMEQK--------AELERLNKQFRTEMEDLMSSKDDVGKSVH-EL 810
Query: 977 PKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSK 1036
K +K L++ VE+++ ++ E+ ++ ++ + L+ + L
Sbjct: 811 EK------SKRALEQQVEEMKTQLEELEDELQ--ATEDAKLRLEVNLQAMKAQFERDLQG 862
Query: 1037 NDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
D + +K +L + +++++ A+LE ++ + A + +L + + KN
Sbjct: 863 RDEQSEEKKKQL---VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 919
Query: 1097 RE---AQINKLSADLKNA-TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKI 1152
R+ Q+ KL A +K+ L T + +
Sbjct: 920 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 979
Query: 1153 DQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQA 1212
++ K + +E + +I + +R+E +++ ++ + +
Sbjct: 980 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1039
Query: 1213 VVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA---DYENKITS-LEST 1268
+++ +L E+ Q K E+ LE + ++LK + E + S +++
Sbjct: 1040 KKANLQIDQINADLNLERGHAQ----KNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1095
Query: 1269 IAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
I A + I QLE+ L T ++ A V E + DE NA
Sbjct: 1096 ITALEAKIAQLEEQLDNETKER-QAACKQVRRTEKK-----LKDVLLQVDDERRNA---- 1145
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
E+ + ++ A + QLK L + E A ++ ++ S +
Sbjct: 1146 EQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLK 1205
Query: 1389 KKLDR 1393
KL R
Sbjct: 1206 NKLRR 1210
Score = 87.4 bits (207), Expect = 5e-16
Identities = 217/1120 (19%), Positives = 414/1120 (36%), Gaps = 110/1120 (9%)
Query: 709 EMKLLLELNEQEATVLRRKVE--ELEQDKEALKKQVKELTSKISSVT--KTSAGSNTTAR 764
++K LL+++ QE ++ ++ E ++ + + A + ++ E+ + S + K A
Sbjct: 119 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLMEMETLQSQLMAEKLQLQEQLQAE 178
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
L + +L R+ + E++E+ L + + E + L +KK + I+
Sbjct: 179 TELCAEAEEL-RARLTAKKQELEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQELEEQ 237
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
++++ K QL+ + EA K + LE + L+ +N KL K L D+ +
Sbjct: 238 LEEEESARQKLQLEKVTTEA-----KLKKLEEEQIILEDQNCKLA---KEKKLLEDRIAE 289
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDE----KSEKKVRFTEATKKE-----TDTLKS 935
T T + E A K K MI E + EK+ + E T+++ TD
Sbjct: 290 FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ 349
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED 995
QA L ++++A + K KK +L + Q+ ++ ED
Sbjct: 350 IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ--KNMALKKIRELES--QISELQED 405
Query: 996 LECEIGEMYVVMKNAGLSGKEMTA-KTKLEKEIDEIRSKL---SKNDSEFTNEKNRLQTE 1051
LE E K G+E+ A KT+LE +D ++ SK + E K L+ E
Sbjct: 406 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 465
Query: 1052 I----AKLKDVNAK-----------LEGDKDVFANKYKA---LENENSNLSNQCKTLTEE 1093
A+++++ K LE K V AN KA LENE L+N+ K L +
Sbjct: 466 AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQG 525
Query: 1094 MKNREAQINKLSADLK------------------NATSLQTTMSDCMXXXXXXXXXXXXX 1135
++ E + K+ A L+ T LQ + +
Sbjct: 526 GRDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 585
Query: 1136 XXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX-----XXXXXXXCKRIEKQ 1190
Q+ + ++ Q++N+ + K K++ D +EKQ
Sbjct: 586 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEEAKHNLEKQ 645
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQARFIKTESKFITL 1247
++T +V R+L + L+ +E A + K E L
Sbjct: 646 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL 705
Query: 1248 EAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXX 1307
+ E+ DL D +++ S + K QL A +T + KY E E E R
Sbjct: 706 QQELDDLLVDLDHQRQS-ACNLEKKQKKFDQLL-AEEKTISAKYAEERDRAE-AEAREKE 762
Query: 1308 XXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK-----------LENXX 1356
++ + K +LE+ + ++ K D+ K LE
Sbjct: 763 TKALSLARALEEAMEQ-KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV 821
Query: 1357 XXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKL 1416
E+ L+ +LQ+ + + +R D+ + K +L ++
Sbjct: 822 EEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 881
Query: 1417 KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL 1476
+ ++ +++ E +K LE + +E + L+ + L
Sbjct: 882 EAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 941
Query: 1477 ---TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAA---WNTEKTEMQNSIASLQ 1530
+E+ + +K+L + E+ LQE+L A E+ E+ + IA+
Sbjct: 942 DDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSS 1001
Query: 1531 ERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERV 1590
+ G E+ RL AR+ Q E EL +++ +D D
Sbjct: 1002 GK--GALALEEKRRLEARIAQLEEELEEEQGNTELI---NDRLKKANLQIDQINADL--- 1053
Query: 1591 SKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQ 1650
++R E K ++ E T K++Y+ + + ++ L Q
Sbjct: 1054 -NLERGHAQKNENARQQLERQNK--ELKVKLQEMEGT-VKSKYKASITALEAKIAQLEEQ 1109
Query: 1651 VSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDE-EEYRNKVALLEQQVA 1709
+ +ER + + +K + ++ R RN+ D+ ++ ++ L++Q+
Sbjct: 1110 LDNETKERQAACKQVRRTEKKLKDVLLQVDDER--RNAEQYKDQADKASTRLKQLKRQLE 1167
Query: 1710 CLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNE 1749
E+E + KL EL +A+ E+ S N+
Sbjct: 1168 EAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1207
Score = 86.2 bits (204), Expect = 1e-15
Identities = 198/1102 (17%), Positives = 421/1102 (38%), Gaps = 72/1102 (6%)
Query: 474 RIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE 533
++K L Q V+R E + + EL + K + LM++ ++ ++ + Q
Sbjct: 119 KVKPLLQ-VSRQEEEMMAKEEELVKVREKQLAAENRLMEMETLQSQLMAEKLQLQEQLQA 177
Query: 534 DPAQLLRDLQDSLER----EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDI 589
+ +L + ++ R + +L E + E ++ +K+ M NI +
Sbjct: 178 E-TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQELE- 235
Query: 590 HESETVTNSIQNKMIHAASTPSSKEKSDSPPLSID----KTTEETQFHFDLPYLSIFNHM 645
+ E ++ Q + +T + +K + + ++ K +E + D N
Sbjct: 236 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 295
Query: 646 AANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEA 705
K+ A+++ +E+++ L++ + ++ KL ++ + +D+ +A
Sbjct: 296 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 355
Query: 706 DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR 765
AE+K+ L E+E +VEE K K+++EL S+IS + + S +R
Sbjct: 356 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL-QEDLESERASRN 414
Query: 766 SLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
L EE ++ L+ E+++ ++ + E+++ +K + K+
Sbjct: 415 KAEKQKRDLGEE-LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 473
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL-QT-ENKKLQLLKNAKSLRSDKAL 883
+ + ++ Q +E+ A L +T+ ++A+ EK QT EN++ +L K L
Sbjct: 474 QEMR----QKHSQAVEELAEQLE-QTKRVKANLEKAKQTLENERGELANEVKVLLQG-GR 527
Query: 884 DLNTKKTTQLENELKEALAKIKELEMI---CQDEKSEKKVRFTEAT--KKETDTLKSKQX 938
D + K ++E +L+E K E E + D+ ++ +V T ++D+ SK
Sbjct: 528 D-SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLT 586
Query: 939 XXXXXXXXXXXXXXXXXXXQATLK-----SLK--DDAQKSFKPRIPKKPTDLTTKLQLKK 991
+ K LK +D + SF+ ++ ++ + K L+K
Sbjct: 587 KDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEE--AKHNLEK 644
Query: 992 MVEDLECEIGEMYVVMKNA-GLSGKEMTAKTKLEKEIDEIRSKLSKNDSEF---TNEKNR 1047
+ L ++ +M M+++ G K KL+K+++ + + + + + K R
Sbjct: 645 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 704
Query: 1048 LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLT----EEMKNREAQI-N 1102
LQ E L D+ L+ + N K + + L+ + KT++ EE EA+
Sbjct: 705 LQQE---LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE-KTISAKYAEERDRAEAEARE 760
Query: 1103 KLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKE 1162
K + L A +L+ M + ++++ K L ++
Sbjct: 761 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 820
Query: 1163 VGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQ-AVVLANTHRR 1221
V + ++ + R+E L K + + L R
Sbjct: 821 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE 880
Query: 1222 LSIELTSEKDELQ---ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQ 1278
+ EL E+ + A K E LEA + + + I L A +++
Sbjct: 881 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 940
Query: 1279 LEDA-------LRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT 1331
L+D L Q ++ + EM++++ Q E + ++ +
Sbjct: 941 LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS 1000
Query: 1332 EAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL 1391
+ + A E +L++ +A+LE + +++ DL ER
Sbjct: 1001 SGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINADLNLER--- 1057
Query: 1392 DRMRIAHDKDVKNKDAELATLKGKLKI-LEQNSGAGAKRITELKQEYEETVKKLEHSLAL 1450
H + +N +L +LK+ L++ G + E + +LE L
Sbjct: 1058 -----GHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN 1112
Query: 1451 EKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKE-LSTALGEIKTLQEKLG 1509
E E + + E++ + L V+ E+ E Q + ST L ++K E+
Sbjct: 1113 ETKERQAACKQVRRTEKK--LKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1170
Query: 1510 TESAAWNTEKTEMQNSIASLQE 1531
E+ N + ++Q + E
Sbjct: 1171 EEAQRANASRRKLQRELEDATE 1192
Score = 85.0 bits (201), Expect = 2e-15
Identities = 200/980 (20%), Positives = 396/980 (40%), Gaps = 105/980 (10%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E + L K +N E + +ER RR + +E EKT R + S+ D +Q +
Sbjct: 297 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 356
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
LK + + ++E + QI L+++++ R
Sbjct: 357 ----IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 412
Query: 287 CERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ-QKVNELTTHNEDLRDEKKHLTQ 345
+ EK+K D+ G E LK + + + T ++LR +++ Q
Sbjct: 413 RNKAEKQKRDL----------------GEELEALKTELEDTLDSTAAQQELRSKRE---Q 453
Query: 346 KIREIESELETRPST-EAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXX 404
++ ++ LE T EAQ +++ Q ++ A E L E+L ++ + +K L
Sbjct: 454 EVNILKKTLEEEAKTHEAQIQEMRQKHSQ--AVEELAEQL-EQTKRVKANL--------- 501
Query: 405 MQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG 464
+ ++ +E L E++ ++ R K KK E + +L+ + E E+ E+
Sbjct: 502 --EKAKQTLENERGELANEVKVLLQGGRDSEHKRKKVEAQLQELQVKFNEGERVRTELAD 559
Query: 465 GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
+Q E + + +++S + +L ++ + S+ + L + K+S S
Sbjct: 560 KVTKLQVE--LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ---EENRQKLSLS 614
Query: 525 SLTRGGSQEDPAQLLRDLQDSLEREA--DLREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
T+ ED R+ + E EA +L +Q+ + A+ K+ M D
Sbjct: 615 --TKLKQVEDEKNSFREQLEEEEEEAKHNLEKQIATLHAQVADM----------KKKMED 662
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIF 642
+ V C + +E V +Q K + S ++ + L KT + + DL
Sbjct: 663 S-VGC-LETAEEVKRKLQ-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD-DLLVDLDH 718
Query: 643 NHMAANNLRKTAARVEE-DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKE 701
+A NL K + ++ E + K + R+ + LS+ A + ++
Sbjct: 719 QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ 778
Query: 702 TDEADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSV-TKTSAG 758
E + + E+ + ++ + + V ELE+ K AL++QV+E+ +++ + + A
Sbjct: 779 KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT 838
Query: 759 SNTTARRSLTTNSNKLAEER-VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTL 817
+ R + + K ER ++ +++ +E +K+L+ + R+ E AEL +K+
Sbjct: 839 EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME---AELEDERKQ---- 891
Query: 818 IKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE--KLQTENKK-LQLLKNA 874
+S ++ A + +DLK + EA + A EA + KLQ + K ++ L +
Sbjct: 892 -RSMAVAARKKLEMDLK------DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 944
Query: 875 KSLRSDKALDL--NTKKTTQLENE---LKEALAKIKELEMICQDEKSEKKVRFTEATKKE 929
++ R + N KK +E E L+E LA + + Q E+ E ++ K
Sbjct: 945 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKG 1004
Query: 930 TDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK------DDAQKSFKPRIPKKPTDL 983
L+ K+ + LK D +
Sbjct: 1005 ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINADLNLERGHAQKNE 1064
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
+ QL++ ++L+ ++ EM +K+ K + T LE +I ++ +L E
Sbjct: 1065 NARQQLERQNKELKVKLQEMEGTVKS-----KYKASITALEAKIAQLEEQLDNETKERQA 1119
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENS----NLSNQCKTLTEEMKNREA 1099
+++ KLKDV +++ D+ A +YK ++ S L Q + EE + A
Sbjct: 1120 ACKQVRRTEKKLKDVLLQVD-DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANA 1178
Query: 1100 QINKLSADLKNATSLQTTMS 1119
KL +L++AT M+
Sbjct: 1179 SRRKLQRELEDATETADAMN 1198
Score = 74.9 bits (176), Expect = 3e-12
Identities = 190/985 (19%), Positives = 368/985 (37%), Gaps = 120/985 (12%)
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
+++ +++ +E +++ + + L A+N ++ E + QL+ A+ L+ + L T+ +
Sbjct: 128 RQEEEMMAKEEELVKVREKQLAAENRLMEMETLQSQLM--AEKLQLQEQLQAETELCAEA 185
Query: 894 ENELKEALAKIKELEMICQD-----EKSEKKVRFTEATKKETD-TLKSKQXXXXXXXXXX 947
E AK +ELE IC D E+ E++ + +A KK+ ++ +
Sbjct: 186 EELRARLTAKKQELEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQELEEQLEEEESAR 245
Query: 948 XXXXXXXXXXQATLKSLKDDA-------------QKSFKPRIPKKPTDLTTKLQLKKMVE 994
+A LK L+++ +K + RI + T+LT + + K +
Sbjct: 246 QKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLA 305
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
L+ + M ++ + + + K +E+++ R KL + ++ +++ LQ +IA+
Sbjct: 306 KLKNKHEAMITDLE------ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 359
Query: 1055 LKDVNAKLEGD--------KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
LK AK E + ++ A K AL+ L +Q L E++++ A NK
Sbjct: 360 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE-LESQISELQEDLESERASRNKAEK 418
Query: 1107 ---DL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKE 1162
DL + +L+T + D + ++ K + +
Sbjct: 419 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE------AQ 472
Query: 1163 VGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLA----NT 1218
+ + +K KR++ L K T V+L +
Sbjct: 473 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ--TLENERGELANEVKVLLQGGRDSE 530
Query: 1219 HRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQ 1278
H+R +E ++ ELQ +F + E L ++ L+ + +N +T L S +K + +
Sbjct: 531 HKRKKVE--AQLQELQVKFNEGERVRTELADKVTKLQVELDN-VTGLLSQSDSKSSKLTK 587
Query: 1279 LEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSA- 1337
AL D + + E +DE N+ + +LE+ E E+
Sbjct: 588 DFSALESQLQDTQEL------LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEEAKHN 641
Query: 1338 AKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIA 1397
+ ++A L + +A ++ E ++L DL+ ++ + A
Sbjct: 642 LEKQIATLHAQVADMKKKMEDSVGCLETA-------EEVKRKLQKDLEGLSQRHEEKVAA 694
Query: 1398 HDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEE 1457
+DK K K L L L+ + E KQ KK + LA EK
Sbjct: 695 YDKLEKTKTRLQQELDDLLVDLDHQRQSACN--LEKKQ------KKFDQLLAEEKT---- 742
Query: 1458 LTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNT 1517
++ KY E + +AR EKE L +E E++ L ++ TE +
Sbjct: 743 ISAKYAE-ERDRAEAEAR---EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 798
Query: 1518 EKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXX 1577
K ++ S+ L++ +VE + +L++ E EL+A D + LE +
Sbjct: 799 SKDDVGKSVHELEKSKRALEQQVEE--MKTQLEELEDELQATEDAKLRLEVNLQAMKAQF 856
Query: 1578 XXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQM 1637
+ K Q +E K R + K
Sbjct: 857 ERDLQGRDEQSEEKKKQ---------LVRQVREMEAELEDERKQRSMAVAARKK------ 901
Query: 1638 NTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEY 1697
+ +LK L + + RD + L Q M + R R I + +E
Sbjct: 902 --LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENE 959
Query: 1698 RN------KVALLEQQVACLE----------DELCESRLLASKLNTELVSEKSSAEVRLA 1741
+ ++ L++++A E DEL + +S + EK E R+A
Sbjct: 960 KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIA 1019
Query: 1742 EMQSRLNEYEEERLLSSGRARVAGL 1766
+++ L E + L + R + A L
Sbjct: 1020 QLEEELEEEQGNTELINDRLKKANL 1044
Score = 60.9 bits (141), Expect = 5e-08
Identities = 74/349 (21%), Positives = 154/349 (44%), Gaps = 24/349 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERV--EKEKSDILLRRL-ANIDTANKYTTGRSSEVLKLQ 323
K+ Q+ ++ E++ RK+ ++K ++ L+ L A+ID+ANK ++ KLQ
Sbjct: 872 KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 931
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
++ + +D R ++ + + +E E +L+ S EA ++ QL+ +L AAE +
Sbjct: 932 AQMKDCMRELDDTRASREEILAQAKENEKKLK---SMEA---EMIQLQEELAAAERAKRQ 985
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
E +++ E+ + + R +A + L ELE+ N +++ +LKK
Sbjct: 986 AQQERDELADEIANSSGKGALALEEKRRLEA-RIAQLEEELEEEQGNTELINDRLKKANL 1044
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQEVARSTEVAL-RLQRELA 497
+ DQ+ + + ++R+N +++E+E V + ++ L+ ++A
Sbjct: 1045 QIDQINADLNLERGHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1104
Query: 498 EANSKFTGSNPSLMKVPQP--ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE-READLRE 554
+ + + T K + L + + A+ +D D R L+
Sbjct: 1105 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1164
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM 603
QL AEEE ++ N ++ + D T D E +S++NK+
Sbjct: 1165 QLEEAEEE---AQRANASRRKLQRELEDATETADAMNRE--VSSLKNKL 1208
Score = 56.4 bits (130), Expect = 1e-06
Identities = 96/526 (18%), Positives = 212/526 (40%), Gaps = 44/526 (8%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS-SEVLKLQQKV 326
Q +++ L ++D R+ +EK+ K D LL I R+ +E + + K
Sbjct: 706 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 765
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELM 385
L E+ ++K L + ++ +E+E S++ + + +L A E EE+
Sbjct: 766 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 825
Query: 386 DENEDMKKELRD-------LXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ E+++ EL+ L M+ F D + +Q ++ R + +L
Sbjct: 826 TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 885
Query: 439 K--KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+ + +R ++K E + K LE R+ IK+L + A+ + L
Sbjct: 886 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTR 945
Query: 497 AEANSKFTGS--NPSLMKVPQPETVKVSR----SSLTRGGSQEDPAQLLRDLQDSLEREA 550
A + N +K + E +++ + + +Q++ +L ++ +S + A
Sbjct: 946 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1005
Query: 551 DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
E+ R E A ++ + +++ D + ++ + + + + + HA
Sbjct: 1006 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL-QIDQINADLNLERGHAQKNE 1064
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE--DNESLLLQL 668
+++++ + + +E + Y + + A A++EE DNE+ Q
Sbjct: 1065 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK-----IAQLEEQLDNETKERQA 1119
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
+ +KL L ++ N E+ D+AD A +L L+R++
Sbjct: 1120 ACKQVRRTEKKLKDV----LLQVDDERRNAEQYKDQADKASTRL---------KQLKRQL 1166
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
EE E++ + ++L ++ T+T+ N R +++ NKL
Sbjct: 1167 EEAEEEAQRANASRRKLQRELEDATETADAMN----REVSSLKNKL 1208
Score = 56.0 bits (129), Expect = 1e-06
Identities = 102/615 (16%), Positives = 234/615 (38%), Gaps = 51/615 (8%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAAKDVHIKQLED 1281
+L EK L+ R + + E + + L K +E IT LE + ++ ++LE
Sbjct: 275 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 334
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
R+ D D + ++ E++ ++EL A ++E+ A+ + A +
Sbjct: 335 TRRKLEGDSTDLSD---QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK 391
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL---DRMRIAH 1398
+ +L+S +++L+ + + L T+L+ +R
Sbjct: 392 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 451
Query: 1399 DKDV----KNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+++V K + E T + +++ + Q + + E ++ + LE + + E
Sbjct: 452 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 511
Query: 1455 YEELTGKYELL-----EEEHVVTKARLTVEK--------EQAQGELLHVQKELSTALGEI 1501
EL + ++L + EH K +++ E+ + EL +L L +
Sbjct: 512 RGELANEVKVLLQGGRDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 571
Query: 1502 KTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAAND 1561
L + ++S+ + + +++ + QE L E R +L+ ++ E +
Sbjct: 572 TGLLSQSDSKSSKLTKDFSALESQLQDTQELL----QEENRQKLSLSTKLKQVEDEKNSF 627
Query: 1562 RRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIE----- 1616
R + E + + K +E
Sbjct: 628 REQLEEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR 687
Query: 1617 -QSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE--------- 1666
+ + A ++ TKTR + +++ + +L +++ + Q+L
Sbjct: 688 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 747
Query: 1667 AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLN 1726
A ++ AE + +K + + + + E + ++ L +Q ++L S+ K
Sbjct: 748 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 807
Query: 1727 TELVSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKE---RDEQQ 1782
EL K + E ++ EM+++L E E+E + + R+ M+ + ++ RDEQ
Sbjct: 808 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 867
Query: 1783 RLLQETSTLARDLRQ 1797
++ L R +R+
Sbjct: 868 E--EKKKQLVRQVRE 880
Score = 54.0 bits (124), Expect = 5e-06
Identities = 124/629 (19%), Positives = 252/629 (40%), Gaps = 64/629 (10%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
+E ++ L++++ L + ++K+ D + ++TA + ++ L Q+
Sbjct: 633 EEEEEAKHNLEKQIATLHAQVADMKKKMED----SVGCLETAEEVKRKLQKDLEGLSQRH 688
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE-TLCEELM 385
E + L K L Q++ ++ +L+ + + + ++ +LLA E T+ +
Sbjct: 689 EEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYA 748
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
+E + + E R+ + E+ ++ + L R +Q L +
Sbjct: 749 EERDRAEAEAREKETKALSLARAL-EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 807
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
+LE+ K E+++ E+ + +++ELE E+ + + LRL+ L ++F
Sbjct: 808 HELEKSKRALEQQVEEM---------KTQLEELEDELQATEDAKLRLEVNLQAMKAQF-- 856
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
E R S+E QL+R ++ E EA+L ++ + A
Sbjct: 857 -----------ERDLQGRDEQ----SEEKKKQLVRQVR---EMEAELEDERKQRSMAVAA 898
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHESETVTN--SIQNKMIHAASTPSSKEKSDSPPLSI 623
K++ +D + + +I + + + E + +Q +M S L+
Sbjct: 899 RKKLE----MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 954
Query: 624 DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED---NESLLLQLKKMATKARSRKL 680
K E+ + + + +AA K A+ E D +E K R+L
Sbjct: 955 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1014
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKK 740
+ +E N E D A +++ ++N + + R ++ E ++ L++
Sbjct: 1015 EARIAQLEEELEEEQGNTELINDRLKKANLQID-QINA-DLNLERGHAQKNENARQQLER 1072
Query: 741 QVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDC 800
Q KEL K+ + T + + S+T K+A+ LE+++D K+ +
Sbjct: 1073 QNKELKVKLQEMEGTV---KSKYKASITALEAKIAQ-----LEEQLDNETKERQAACKQV 1124
Query: 801 ERLHAELS--LAQKKPKTLIKSRSLDASDQQNV---DLKRQLQVIEQE---ASVLRAKTQ 852
R +L L Q + + D +D+ + LKRQL+ E+E A+ R K Q
Sbjct: 1125 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1184
Query: 853 -SLEADNEKLQTENKKLQLLKNAKSLRSD 880
LE E N+++ LKN K R D
Sbjct: 1185 RELEDATETADAMNREVSSLKN-KLRRGD 1212
Score = 53.6 bits (123), Expect = 7e-06
Identities = 85/398 (21%), Positives = 159/398 (39%), Gaps = 36/398 (9%)
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE-----EHVVTKARLTVEKEQAQGE 1486
E+ + EE VK E LA E E T + +L+ E E + + L E E+ +
Sbjct: 132 EMMAKEEELVKVREKQLAAENRLMEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRAR 191
Query: 1487 LLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLN 1546
L ++EL +++ E+ EK +MQ +I L+E+L E E AR
Sbjct: 192 LTAKKQELEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQELEEQL----EEEESARQK 247
Query: 1547 ARLDQ--RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXX 1604
+L++ E +L+ + + +LE + ++ +
Sbjct: 248 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 307
Query: 1605 XXXXXXXXXXIEQ---SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNY 1661
+E+ E+ ++ E+ T+ + EG + D++ L Q++ + +
Sbjct: 308 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 367
Query: 1662 KQML---------EAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVAL----LEQQV 1708
++ L EAAQK+MA K + ++I E RNK L +++
Sbjct: 368 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 427
Query: 1709 ACLEDELCESRLLASKLNTELVSEKSSAEVRL----AEMQSRLNEYEEERLLSSGRARVA 1764
L+ EL E L ++ EL S K EV + E +++ +E + + + V
Sbjct: 428 EALKTEL-EDTLDSTAAQQELRS-KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 485
Query: 1765 GLATRMELAWHKERD---EQQRLLQETSTLARDLRQTL 1799
LA ++E + + +Q L E LA +++ L
Sbjct: 486 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 523
Score = 45.2 bits (102), Expect = 0.002
Identities = 112/566 (19%), Positives = 210/566 (37%), Gaps = 54/566 (9%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR 1284
EL +E +EL+AR + + LE DL+A E + + A K + +++
Sbjct: 180 ELCAEAEELRARLTAKKQE---LEEICHDLEARVEEEEERYQHLQAEKKKMQQNIQELEE 236
Query: 1285 QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDE---LNNAKIKLEKTEAESSAAKLE 1341
Q ++ +E V +D+ L K LE AE + E
Sbjct: 237 QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE 296
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+ LAKL+N E K ++ +L+ R+KL+
Sbjct: 297 EEEKSKSLAKLKNKHEAMITDLEERLRR----EEKQRQ---ELEKTRRKLEGDSTDLSDQ 349
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITE--------LKQ--EYEETVKKLEHSLALE 1451
+ A++A LK +L E+ A R+ E LK+ E E + +L+ L E
Sbjct: 350 IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESE 409
Query: 1452 KAEYEELTGKYELLEEEHVVTKARL--TVEKEQAQGELLHVQKELSTALGEIKTLQEKLG 1509
+A + + L EE K L T++ AQ EL +++ L KTL+E+
Sbjct: 410 RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK--KTLEEEAK 467
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHH 1569
T A + + ++ L E+L + R+ A L++ ++ L N+R ++
Sbjct: 468 THEAQIQEMRQKHSQAVEELAEQL------EQTKRVKANLEKAKQTLE--NERGELANE- 518
Query: 1570 HDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEIT-D 1628
D E K ++ E ++K K ++ D
Sbjct: 519 -------VKVLLQGGRDSEH--KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 569
Query: 1629 TKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNS 1688
T G ++ + L S + + +++L+ + + K +NS
Sbjct: 570 NVT---GLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 626
Query: 1689 ISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEV--RLAEMQSR 1746
EEE LE+Q+A L ++ + + K+ + +++ EV +L +
Sbjct: 627 FREQLEEEEEEAKHNLEKQIATLHAQVAD---MKKKMEDSVGCLETAEEVKRKLQKDLEG 683
Query: 1747 LNEYEEERLLSSGRARVAGLATRMEL 1772
L++ EE++ + + + EL
Sbjct: 684 LSQRHEEKVAAYDKLEKTKTRLQQEL 709
Score = 41.1 bits (92), Expect = 0.039
Identities = 24/114 (21%), Positives = 54/114 (47%), Gaps = 5/114 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+++ + + ++Q++ +E K+ R EK+ D+LL+ +D + + K
Sbjct: 1099 LEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ----VDDERRNAEQYKDQADK 1154
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST-EAQTRQIEQLRAKL 374
++ +L E+ +E + R+++ ELE T +A R++ L+ KL
Sbjct: 1155 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1208
>EF179180-1|ABN05283.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 99 bits (238), Expect = 8e-20
Identities = 162/837 (19%), Positives = 342/837 (40%), Gaps = 71/837 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSD-LSRELEEISERLEEAGGATSVQIE 1162
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 1163 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQ +E+ S E ++++ + L+ +
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND---LTSQR 1277
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+EV +A LQ
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1337
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRTKYETDAIQRTEELEEAKKKLA 1394
Query: 551 D-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L+E E A C + + + D +V D+ S ++ K +
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 1452
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 1510
Query: 663 SLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL T K+ A K+ +++A + E + + ++ LE N+ +A
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ R+ E+ E+ ++A + ++ + S +TS + T +R K+
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETRSRNEALRVKKKM------- 1618
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 1619 -EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 840 IEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ ++L+A+ + L A E+ + E + ++ + + L S +N KK +++
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK--KMD 1731
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + +++E C++ + + K T+A + LK +Q
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1790
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K + +L+ +E + E M+ +
Sbjct: 1791 KDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEAEQKRNAESVKGMRKSERRI 1847
Query: 1015 KEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE+T +T +L+ +D+++ K+ + + + T ++K + V +L+
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Score = 83.0 bits (196), Expect = 1e-14
Identities = 190/1032 (18%), Positives = 396/1032 (38%), Gaps = 71/1032 (6%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +A K + +L+ S+ + +L+ ++ + QE + L+ + Q+ E DN E
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-EQDN-LADAEE 903
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE-KKVRFTE 924
+ QL+KN L + K ++N + + E E AK ++LE C + K + + T
Sbjct: 904 RCDQLIKNKIQLEA-KVKEMNERLEDEEEMNA-ELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 925 A-TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
A +KE ++K + L+ A + K T
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
K++L++ V+DLE + + V + + +++ KL +E I +ND + +
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE--SIMDL--ENDKQQLD 1077
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
E RL+ + +L +NA++E ++ + + K L+ + + + L E R A++ K
Sbjct: 1078 E--RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR-AKVEK 1134
Query: 1104 LSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKLLK 1161
L +DL + + + + ++ T + + L K
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
+ D ++G+ ++ + + D VT + T
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
E S+ +E Q S+ L+ E +L + K + K + +QLED
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
RQ +E + + +E AK +L++ S A E
Sbjct: 1315 LKRQLE----EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSE 1367
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+AQ ++ K E + +A+E + ++ L++ + +
Sbjct: 1368 VAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+++ ++ L++ K + E KQ+YEE+ +LE S ++ EL
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 1462 YELLEE--EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
EE EH+ T R E + Q E+ + ++L ++ I L EK+ + A EK
Sbjct: 1485 KNAYEESLEHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQLEA---EK 1537
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDVLEHHH----DXX 1573
E+Q+++ + L ++ RA+L N + ER+L ++ + + +H D
Sbjct: 1538 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 1597
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTR- 1632
+ RV K ++ K+ ++ + DT+ +
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Query: 1633 ----------------YEGQMNTMRDELKSLHNQVSRFRRERDNYKQ-MLEAAQKSMAEI 1675
E + N ++ EL+ L V + R R +Q ++E +++ ++
Sbjct: 1658 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER--VQL 1715
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE----LCESRLLASKLNTE--- 1728
+ ++ I++ D + + +V Q+ E++ + ++ ++A +L E
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1775
Query: 1729 ---LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
L K + E + ++Q RL+E E+ L G+ ++ L R+ ++ EQ+R
Sbjct: 1776 SAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834
Query: 1786 QETSTLARDLRQ 1797
+ + + R+
Sbjct: 1835 ESVKGMRKSERR 1846
Score = 75.4 bits (177), Expect = 2e-12
Identities = 191/1082 (17%), Positives = 411/1082 (37%), Gaps = 82/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 859 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 914
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 915 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----RDIDDLELTLAKVEKEK 968
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 1019
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + +ER
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 1139
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 1140 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 1260 RSKAEETQRSVND--LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 1316
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 1317 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1374
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 1128 XXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K + +L SER + L + K DA+L
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1852
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1853 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1912
Query: 1566 LE 1567
E
Sbjct: 1913 AE 1914
Score = 70.9 bits (166), Expect = 4e-11
Identities = 236/1189 (19%), Positives = 464/1189 (39%), Gaps = 146/1189 (12%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + +L+ L +E +EL ++ + +E DL
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 406 QDNFR--EDQADEYSSLRRELEQTIK--NCRV---------LSFKLKKTERKADQLEQEK 452
QDN E++ D+ + +LE +K N R+ L+ K +K E + +L+++
Sbjct: 895 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 954
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E+ +L +E + L
Sbjct: 955 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-- 1010
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E +R L A+ + ++
Sbjct: 1011 --QAEEDKVN--TLTKAKVKLE--QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ +D + ++ + + ++ K + + E + + K +E Q
Sbjct: 1065 SIMDLE-----------NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
+ + + A R A+VE+ L +L+++ S +L A + IE
Sbjct: 1114 RIE----ELEEELEAE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSVQIE 1162
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSK 748
N E E + + L+ +E A LR+K V EL + + L++ VK+ K
Sbjct: 1163 M-NKKREAEFQKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEK 1219
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS 808
S K T+ + L E+ + LED+++E R K E +R +L+
Sbjct: 1220 EKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVN----DLT 1274
Query: 809 LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL-RAK---TQSLEADNEKLQTE 864
+ K +T +N +L RQL E S L R K TQ LE +L+ E
Sbjct: 1275 SQRAKLQT------------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 865 NKKLQLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
K L +A +S R D DL + Q E E EA A+++ + E ++ +
Sbjct: 1323 VKAKNALAHALQSARHD--CDLLRE---QYEEET-EAKAELQRVLSKANSEVAQWR---- 1372
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
TK ETD ++ + + L +A+++ + K +
Sbjct: 1373 --TKYETDAIQRTEELEEA---------------KKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
TK +L+ +EDL ++ NA + + + +K + E + K ++ SE +
Sbjct: 1416 KTKHRLQNEIEDLMVDVER-----SNAAAAALDKKQRN-FDKILAEWKQKYEESQSELES 1469
Query: 1044 ---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
E L TE+ KLK NA E + + EN NL + LTE++ +
Sbjct: 1470 SQKEARSLSTELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKT 1522
Query: 1101 INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLL 1160
I++L K + + + + Q+ K ++
Sbjct: 1523 IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---------KAEIE 1573
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+++ +K +++ + ++ + +R + + + L++ +
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R++ E + LQ+ T+ I L+ +R D + I +E +++L
Sbjct: 1634 -RMAAEAQKQVKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEEL 1688
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+ QT + +E E R Q + +A + +TE E + +
Sbjct: 1689 RAVVEQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
A+ K+ K S++ E K ++ ++ + +LD A
Sbjct: 1748 CRNAEEKA--KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQ 1802
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+K +L L+ +++ LE A KR E + ++K E +++ Y+
Sbjct: 1803 IALKGGKKQLQKLEARVRELENELEAEQKR----NAESVKGMRKSER--RIKELTYQTEE 1856
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ LL + +V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 1857 DRKNLLRLQDLVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 1903
Score = 68.9 bits (161), Expect = 2e-10
Identities = 173/878 (19%), Positives = 365/878 (41%), Gaps = 91/878 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRSSE 318
+++ D +EG ++ +R ER +++ + D+ L + + +D N + + E
Sbjct: 1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 1086
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L ++ + L+ + K L +I E+E ELE + A ++E+LR+
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA---KVEKLRS------ 1137
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKN-CRVLSF 436
+L E E++ + L + +Q + + E+ +RR+LE+ T+++ +
Sbjct: 1138 ----DLSRELEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 437 KLKKTERKADQLEQ-EKAEHEKKLLEIVGGPDGMQRENRIKELEQEV---ARSTEVALRL 492
+ K + A+ EQ + + K+ LE ++ ++ +EQ + A ++ L
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 493 QRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLERE 549
+ ++ E SK + S+ + Q ++ L+R +++ +QL R ++
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
DL+ QL EEE K N + D + + +E ET + +++ A++
Sbjct: 1313 EDLKRQL---EEEV---KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPY--------LSIFNHMAANNLRKTAARVEEDN 661
++ ++ +I +T E + L + N ++L KT R++ +
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN-AKCSSLEKTKHRLQNEI 1425
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQE 720
E L++ +++ + A + +K+ E +E +++ E+ E + L E
Sbjct: 1426 EDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----STE 1480
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
L+ EE + E K++ K L +IS +T+ GS+ L +L E+++
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKME 1539
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QLQV 839
L+ ++E L +E + L A+L Q K + R L D++ KR L+V
Sbjct: 1540 -LQSALEEAEASLEHEEG--KILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLRV 1593
Query: 840 IEQEASVLRAKTQS----------LEAD-NE---KLQTENK-KLQLLKNAKSLRS-DKAL 883
++ + L A+T+S +E D NE +L N+ + K KSL+S K
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK--VRFTEATKK--ETDTLKSKQXX 939
+ + ++LKE +A ++ + Q E E + V TE ++K E + +++ +
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE-R 1712
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
A L L+ + +++ + + + KK + D
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-------ECRNAEEKAKKAITDAAMM 1765
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDV 1058
E+ K S K +E+ I +++ +L + + K +LQ A+++++
Sbjct: 1766 AEEL---KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1822
Query: 1059 NAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LE ++ A K + + E+ KN
Sbjct: 1823 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1860
Score = 64.1 bits (149), Expect = 5e-09
Identities = 155/870 (17%), Positives = 341/870 (39%), Gaps = 78/870 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ +L ++ + + + L+ + ++QA S L+++L++ L
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA-LGSQLQKKLKELQARIEELE 1119
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQR 494
+L+ ++E+ +++ ++L EI + ++ ++ E+ + E +++R
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L EA + + +L K S+ G Q D L+ ++ LE+E E
Sbjct: 1177 DLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS--E 1223
Query: 555 QLRNAEEETANCKQ-VNPPTFLDKQVMT----DNIVTCDIHESETVTNSI--QNKMIHAA 607
++ T+N +Q + L+K T N E++ N + Q +
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNLRKTAARVEEDNESLL 665
+ S++ + L T + + L L + + A N A + + LL
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 666 LQLKKMATKARSRKLSPTPPANK--LSIETANDNDE-KETDEADPAEMKLLLELNEQEAT 722
+ + T+A++ AN T + D + T+E + A+ KL L E E
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 723 V--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE--- 1455
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++ +
Sbjct: 1456 -WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDL 1512
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
++ LE ++L+ E +LQ + ++ +L+ K + + E +
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQ----SALEEAEASLEHEEGKILRAQLEFNQI 1568
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
A+I E ++ +DE+ E +A + + S Q +
Sbjct: 1569 KAEI-ERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1621
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L + + Q S R+ + LQ +++D + ++ + V N L +
Sbjct: 1622 LNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAIVE 1675
Query: 1021 TK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+ L+ E++E+R+ + + + + + E+ + + L N+ K ++
Sbjct: 1676 RRNNLLQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 1731
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ S L + + +E +N E + K D
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761
>BC112173-1|AAI12174.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 99 bits (238), Expect = 8e-20
Identities = 162/837 (19%), Positives = 342/837 (40%), Gaps = 71/837 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSD-LSRELEEISERLEEAGGATSVQIE 1162
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 1163 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQ +E+ S E ++++ + L+ +
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND---LTSQR 1277
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+EV +A LQ
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1337
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRTKYETDAIQRTEELEEAKKKLA 1394
Query: 551 D-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L+E E A C + + + D +V D+ S ++ K +
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 1452
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 1510
Query: 663 SLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL T K+ A K+ +++A + E + + ++ LE N+ +A
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ R+ E+ E+ ++A + ++ + S +TS + T +R K+
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETRSRNEALRVKKKM------- 1618
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 1619 -EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 840 IEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ ++L+A+ + L A E+ + E + ++ + + L S +N KK +++
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK--KMD 1731
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + +++E C++ + + K T+A + LK +Q
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1790
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K + +L+ +E + E M+ +
Sbjct: 1791 KDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEAEQKRNAESVKGMRKSERRI 1847
Query: 1015 KEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE+T +T +L+ +D+++ K+ + + + T ++K + V +L+
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Score = 83.0 bits (196), Expect = 1e-14
Identities = 190/1032 (18%), Positives = 396/1032 (38%), Gaps = 71/1032 (6%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +A K + +L+ S+ + +L+ ++ + QE + L+ + Q+ E DN E
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-EQDN-LADAEE 903
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE-KKVRFTE 924
+ QL+KN L + K ++N + + E E AK ++LE C + K + + T
Sbjct: 904 RCDQLIKNKIQLEA-KVKEMNERLEDEEEMNA-ELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 925 A-TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
A +KE ++K + L+ A + K T
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
K++L++ V+DLE + + V + + +++ KL +E I +ND + +
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE--SIMDL--ENDKQQLD 1077
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
E RL+ + +L +NA++E ++ + + K L+ + + + L E R A++ K
Sbjct: 1078 E--RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR-AKVEK 1134
Query: 1104 LSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKLLK 1161
L +DL + + + + ++ T + + L K
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
+ D ++G+ ++ + + D VT + T
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
E S+ +E Q S+ L+ E +L + K + K + +QLED
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
RQ +E + + +E AK +L++ S A E
Sbjct: 1315 LKRQLE----EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSE 1367
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+AQ ++ K E + +A+E + ++ L++ + +
Sbjct: 1368 VAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+++ ++ L++ K + E KQ+YEE+ +LE S ++ EL
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 1462 YELLEE--EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
EE EH+ T R E + Q E+ + ++L ++ I L EK+ + A EK
Sbjct: 1485 KNAYEESLEHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQLEA---EK 1537
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDVLEHHH----DXX 1573
E+Q+++ + L ++ RA+L N + ER+L ++ + + +H D
Sbjct: 1538 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 1597
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTR- 1632
+ RV K ++ K+ ++ + DT+ +
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Query: 1633 ----------------YEGQMNTMRDELKSLHNQVSRFRRERDNYKQ-MLEAAQKSMAEI 1675
E + N ++ EL+ L V + R R +Q ++E +++ ++
Sbjct: 1658 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER--VQL 1715
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE----LCESRLLASKLNTE--- 1728
+ ++ I++ D + + +V Q+ E++ + ++ ++A +L E
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1775
Query: 1729 ---LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
L K + E + ++Q RL+E E+ L G+ ++ L R+ ++ EQ+R
Sbjct: 1776 SAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834
Query: 1786 QETSTLARDLRQ 1797
+ + + R+
Sbjct: 1835 ESVKGMRKSERR 1846
Score = 75.4 bits (177), Expect = 2e-12
Identities = 191/1082 (17%), Positives = 411/1082 (37%), Gaps = 82/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 859 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 914
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 915 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----RDIDDLELTLAKVEKEK 968
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 1019
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + +ER
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 1139
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 1140 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 1260 RSKAEETQRSVND--LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 1316
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 1317 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1374
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 1128 XXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K + +L SER + L + K DA+L
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1852
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1853 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1912
Query: 1566 LE 1567
E
Sbjct: 1913 AE 1914
Score = 70.9 bits (166), Expect = 4e-11
Identities = 236/1189 (19%), Positives = 464/1189 (39%), Gaps = 146/1189 (12%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + +L+ L +E +EL ++ + +E DL
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 406 QDNFR--EDQADEYSSLRRELEQTIK--NCRV---------LSFKLKKTERKADQLEQEK 452
QDN E++ D+ + +LE +K N R+ L+ K +K E + +L+++
Sbjct: 895 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 954
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E+ +L +E + L
Sbjct: 955 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-- 1010
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E +R L A+ + ++
Sbjct: 1011 --QAEEDKVN--TLTKAKVKLE--QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ +D + ++ + + ++ K + + E + + K +E Q
Sbjct: 1065 SIMDLE-----------NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
+ + + A R A+VE+ L +L+++ S +L A + IE
Sbjct: 1114 RIE----ELEEELEAE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSVQIE 1162
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSK 748
N E E + + L+ +E A LR+K V EL + + L++ VK+ K
Sbjct: 1163 M-NKKREAEFQKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEK 1219
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS 808
S K T+ + L E+ + LED+++E R K E +R +L+
Sbjct: 1220 EKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVN----DLT 1274
Query: 809 LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL-RAK---TQSLEADNEKLQTE 864
+ K +T +N +L RQL E S L R K TQ LE +L+ E
Sbjct: 1275 SQRAKLQT------------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 865 NKKLQLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
K L +A +S R D DL + Q E E EA A+++ + E ++ +
Sbjct: 1323 VKAKNALAHALQSARHD--CDLLRE---QYEEET-EAKAELQRVLSKANSEVAQWR---- 1372
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
TK ETD ++ + + L +A+++ + K +
Sbjct: 1373 --TKYETDAIQRTEELEEA---------------KKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
TK +L+ +EDL ++ NA + + + +K + E + K ++ SE +
Sbjct: 1416 KTKHRLQNEIEDLMVDVER-----SNAAAAALDKKQRN-FDKILAEWKQKYEESQSELES 1469
Query: 1044 ---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
E L TE+ KLK NA E + + EN NL + LTE++ +
Sbjct: 1470 SQKEARSLSTELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKT 1522
Query: 1101 INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLL 1160
I++L K + + + + Q+ K ++
Sbjct: 1523 IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---------KAEIE 1573
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+++ +K +++ + ++ + +R + + + L++ +
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R++ E + LQ+ T+ I L+ +R D + I +E +++L
Sbjct: 1634 -RMAAEAQKQVKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEEL 1688
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+ QT + +E E R Q + +A + +TE E + +
Sbjct: 1689 RAVVEQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
A+ K+ K S++ E K ++ ++ + +LD A
Sbjct: 1748 CRNAEEKA--KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQ 1802
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+K +L L+ +++ LE A KR E + ++K E +++ Y+
Sbjct: 1803 IALKGGKKQLQKLEARVRELENELEAEQKR----NAESVKGMRKSER--RIKELTYQTEE 1856
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ LL + +V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 1857 DRKNLLRLQDLVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 1903
Score = 68.9 bits (161), Expect = 2e-10
Identities = 173/878 (19%), Positives = 365/878 (41%), Gaps = 91/878 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRSSE 318
+++ D +EG ++ +R ER +++ + D+ L + + +D N + + E
Sbjct: 1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 1086
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L ++ + L+ + K L +I E+E ELE + A ++E+LR+
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA---KVEKLRS------ 1137
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKN-CRVLSF 436
+L E E++ + L + +Q + + E+ +RR+LE+ T+++ +
Sbjct: 1138 ----DLSRELEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 437 KLKKTERKADQLEQ-EKAEHEKKLLEIVGGPDGMQRENRIKELEQEV---ARSTEVALRL 492
+ K + A+ EQ + + K+ LE ++ ++ +EQ + A ++ L
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 493 QRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLERE 549
+ ++ E SK + S+ + Q ++ L+R +++ +QL R ++
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
DL+ QL EEE K N + D + + +E ET + +++ A++
Sbjct: 1313 EDLKRQL---EEEV---KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPY--------LSIFNHMAANNLRKTAARVEEDN 661
++ ++ +I +T E + L + N ++L KT R++ +
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN-AKCSSLEKTKHRLQNEI 1425
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQE 720
E L++ +++ + A + +K+ E +E +++ E+ E + L E
Sbjct: 1426 EDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----STE 1480
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
L+ EE + E K++ K L +IS +T+ GS+ L +L E+++
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKME 1539
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QLQV 839
L+ ++E L +E + L A+L Q K + R L D++ KR L+V
Sbjct: 1540 -LQSALEEAEASLEHEEG--KILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLRV 1593
Query: 840 IEQEASVLRAKTQS----------LEAD-NE---KLQTENK-KLQLLKNAKSLRS-DKAL 883
++ + L A+T+S +E D NE +L N+ + K KSL+S K
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK--VRFTEATKK--ETDTLKSKQXX 939
+ + ++LKE +A ++ + Q E E + V TE ++K E + +++ +
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE-R 1712
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
A L L+ + +++ + + + KK + D
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-------ECRNAEEKAKKAITDAAMM 1765
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDV 1058
E+ K S K +E+ I +++ +L + + K +LQ A+++++
Sbjct: 1766 AEEL---KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1822
Query: 1059 NAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LE ++ A K + + E+ KN
Sbjct: 1823 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1860
Score = 64.1 bits (149), Expect = 5e-09
Identities = 155/870 (17%), Positives = 341/870 (39%), Gaps = 78/870 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ +L ++ + + + L+ + ++QA S L+++L++ L
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA-LGSQLQKKLKELQARIEELE 1119
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQR 494
+L+ ++E+ +++ ++L EI + ++ ++ E+ + E +++R
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L EA + + +L K S+ G Q D L+ ++ LE+E E
Sbjct: 1177 DLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS--E 1223
Query: 555 QLRNAEEETANCKQ-VNPPTFLDKQVMT----DNIVTCDIHESETVTNSI--QNKMIHAA 607
++ T+N +Q + L+K T N E++ N + Q +
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNLRKTAARVEEDNESLL 665
+ S++ + L T + + L L + + A N A + + LL
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 666 LQLKKMATKARSRKLSPTPPANK--LSIETANDNDE-KETDEADPAEMKLLLELNEQEAT 722
+ + T+A++ AN T + D + T+E + A+ KL L E E
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 723 V--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE--- 1455
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++ +
Sbjct: 1456 -WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDL 1512
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
++ LE ++L+ E +LQ + ++ +L+ K + + E +
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQ----SALEEAEASLEHEEGKILRAQLEFNQI 1568
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
A+I E ++ +DE+ E +A + + S Q +
Sbjct: 1569 KAEI-ERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1621
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L + + Q S R+ + LQ +++D + ++ + V N L +
Sbjct: 1622 LNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAIVE 1675
Query: 1021 TK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+ L+ E++E+R+ + + + + + E+ + + L N+ K ++
Sbjct: 1676 RRNNLLQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 1731
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ S L + + +E +N E + K D
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761
>BC112171-1|AAI12172.1| 1935|Homo sapiens myosin, heavy chain 7,
cardiac muscle, beta protein.
Length = 1935
Score = 99 bits (238), Expect = 8e-20
Identities = 162/837 (19%), Positives = 342/837 (40%), Gaps = 71/837 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSD-LSRELEEISERLEEAGGATSVQIE 1162
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 1163 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQ +E+ S E ++++ + L+ +
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND---LTSQR 1277
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+EV +A LQ
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1337
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRTKYETDAIQRTEELEEAKKKLA 1394
Query: 551 D-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L+E E A C + + + D +V D+ S ++ K +
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 1452
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 1510
Query: 663 SLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL T K+ A K+ +++A + E + + ++ LE N+ +A
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ R+ E+ E+ ++A + ++ + S +TS + T +R K+
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETRSRNEALRVKKKM------- 1618
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 1619 -EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 840 IEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ ++L+A+ + L A E+ + E + ++ + + L S +N KK +++
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK--KMD 1731
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + +++E C++ + + K T+A + LK +Q
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1790
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K + +L+ +E + E M+ +
Sbjct: 1791 KDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEAEQKRNAESVKGMRKSERRI 1847
Query: 1015 KEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE+T +T +L+ +D+++ K+ + + + T ++K + V +L+
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Score = 83.0 bits (196), Expect = 1e-14
Identities = 190/1032 (18%), Positives = 396/1032 (38%), Gaps = 71/1032 (6%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +A K + +L+ S+ + +L+ ++ + QE + L+ + Q+ E DN E
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-EQDN-LADAEE 903
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE-KKVRFTE 924
+ QL+KN L + K ++N + + E E AK ++LE C + K + + T
Sbjct: 904 RCDQLIKNKIQLEA-KVKEMNERLEDEEEMNA-ELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 925 A-TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
A +KE ++K + L+ A + K T
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
K++L++ V+DLE + + V + + +++ KL +E I +ND + +
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE--SIMDL--ENDKQQLD 1077
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
E RL+ + +L +NA++E ++ + + K L+ + + + L E R A++ K
Sbjct: 1078 E--RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR-AKVEK 1134
Query: 1104 LSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKLLK 1161
L +DL + + + + ++ T + + L K
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
+ D ++G+ ++ + + D VT + T
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
E S+ +E Q S+ L+ E +L + K + K + +QLED
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
RQ +E + + +E AK +L++ S A E
Sbjct: 1315 LKRQLE----EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSE 1367
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+AQ ++ K E + +A+E + ++ L++ + +
Sbjct: 1368 VAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+++ ++ L++ K + E KQ+YEE+ +LE S ++ EL
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 1462 YELLEE--EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
EE EH+ T R E + Q E+ + ++L ++ I L EK+ + A EK
Sbjct: 1485 KNAYEESLEHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQLEA---EK 1537
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDVLEHHH----DXX 1573
E+Q+++ + L ++ RA+L N + ER+L ++ + + +H D
Sbjct: 1538 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 1597
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTR- 1632
+ RV K ++ K+ ++ + DT+ +
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Query: 1633 ----------------YEGQMNTMRDELKSLHNQVSRFRRERDNYKQ-MLEAAQKSMAEI 1675
E + N ++ EL+ L V + R R +Q ++E +++ ++
Sbjct: 1658 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER--VQL 1715
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE----LCESRLLASKLNTE--- 1728
+ ++ I++ D + + +V Q+ E++ + ++ ++A +L E
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1775
Query: 1729 ---LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
L K + E + ++Q RL+E E+ L G+ ++ L R+ ++ EQ+R
Sbjct: 1776 SAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834
Query: 1786 QETSTLARDLRQ 1797
+ + + R+
Sbjct: 1835 ESVKGMRKSERR 1846
Score = 75.4 bits (177), Expect = 2e-12
Identities = 191/1082 (17%), Positives = 411/1082 (37%), Gaps = 82/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 859 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 914
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 915 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----RDIDDLELTLAKVEKEK 968
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 1019
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + +ER
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 1139
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 1140 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 1260 RSKAEETQRSVND--LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 1316
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 1317 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1374
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 1128 XXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K + +L SER + L + K DA+L
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1852
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1853 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1912
Query: 1566 LE 1567
E
Sbjct: 1913 AE 1914
Score = 70.9 bits (166), Expect = 4e-11
Identities = 236/1189 (19%), Positives = 464/1189 (39%), Gaps = 146/1189 (12%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + +L+ L +E +EL ++ + +E DL
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 406 QDNFR--EDQADEYSSLRRELEQTIK--NCRV---------LSFKLKKTERKADQLEQEK 452
QDN E++ D+ + +LE +K N R+ L+ K +K E + +L+++
Sbjct: 895 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 954
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E+ +L +E + L
Sbjct: 955 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-- 1010
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E +R L A+ + ++
Sbjct: 1011 --QAEEDKVN--TLTKAKVKLE--QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ +D + ++ + + ++ K + + E + + K +E Q
Sbjct: 1065 SIMDLE-----------NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
+ + + A R A+VE+ L +L+++ S +L A + IE
Sbjct: 1114 RIE----ELEEELEAE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSVQIE 1162
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSK 748
N E E + + L+ +E A LR+K V EL + + L++ VK+ K
Sbjct: 1163 M-NKKREAEFQKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEK 1219
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS 808
S K T+ + L E+ + LED+++E R K E +R +L+
Sbjct: 1220 EKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVN----DLT 1274
Query: 809 LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL-RAK---TQSLEADNEKLQTE 864
+ K +T +N +L RQL E S L R K TQ LE +L+ E
Sbjct: 1275 SQRAKLQT------------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 865 NKKLQLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
K L +A +S R D DL + Q E E EA A+++ + E ++ +
Sbjct: 1323 VKAKNALAHALQSARHD--CDLLRE---QYEEET-EAKAELQRVLSKANSEVAQWR---- 1372
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
TK ETD ++ + + L +A+++ + K +
Sbjct: 1373 --TKYETDAIQRTEELEEA---------------KKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
TK +L+ +EDL ++ NA + + + +K + E + K ++ SE +
Sbjct: 1416 KTKHRLQNEIEDLMVDVER-----SNAAAAALDKKQRN-FDKILAEWKQKYEESQSELES 1469
Query: 1044 ---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
E L TE+ KLK NA E + + EN NL + LTE++ +
Sbjct: 1470 SQKEARSLSTELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKT 1522
Query: 1101 INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLL 1160
I++L K + + + + Q+ K ++
Sbjct: 1523 IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---------KAEIE 1573
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+++ +K +++ + ++ + +R + + + L++ +
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R++ E + LQ+ T+ I L+ +R D + I +E +++L
Sbjct: 1634 -RMAAEAQKQVKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEEL 1688
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+ QT + +E E R Q + +A + +TE E + +
Sbjct: 1689 RAVVEQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
A+ K+ K S++ E K ++ ++ + +LD A
Sbjct: 1748 CRNAEEKA--KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQ 1802
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+K +L L+ +++ LE A KR E + ++K E +++ Y+
Sbjct: 1803 IALKGGKKQLQKLEARVRELENELEAEQKR----NAESVKGMRKSER--RIKELTYQTEE 1856
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ LL + +V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 1857 DRKNLLRLQDLVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 1903
Score = 68.9 bits (161), Expect = 2e-10
Identities = 173/878 (19%), Positives = 365/878 (41%), Gaps = 91/878 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRSSE 318
+++ D +EG ++ +R ER +++ + D+ L + + +D N + + E
Sbjct: 1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 1086
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L ++ + L+ + K L +I E+E ELE + A ++E+LR+
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA---KVEKLRS------ 1137
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKN-CRVLSF 436
+L E E++ + L + +Q + + E+ +RR+LE+ T+++ +
Sbjct: 1138 ----DLSRELEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 437 KLKKTERKADQLEQ-EKAEHEKKLLEIVGGPDGMQRENRIKELEQEV---ARSTEVALRL 492
+ K + A+ EQ + + K+ LE ++ ++ +EQ + A ++ L
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 493 QRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLERE 549
+ ++ E SK + S+ + Q ++ L+R +++ +QL R ++
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
DL+ QL EEE K N + D + + +E ET + +++ A++
Sbjct: 1313 EDLKRQL---EEEV---KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPY--------LSIFNHMAANNLRKTAARVEEDN 661
++ ++ +I +T E + L + N ++L KT R++ +
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN-AKCSSLEKTKHRLQNEI 1425
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQE 720
E L++ +++ + A + +K+ E +E +++ E+ E + L E
Sbjct: 1426 EDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----STE 1480
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
L+ EE + E K++ K L +IS +T+ GS+ L +L E+++
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKME 1539
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QLQV 839
L+ ++E L +E + L A+L Q K + R L D++ KR L+V
Sbjct: 1540 -LQSALEEAEASLEHEEG--KILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLRV 1593
Query: 840 IEQEASVLRAKTQS----------LEAD-NE---KLQTENK-KLQLLKNAKSLRS-DKAL 883
++ + L A+T+S +E D NE +L N+ + K KSL+S K
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK--VRFTEATKK--ETDTLKSKQXX 939
+ + ++LKE +A ++ + Q E E + V TE ++K E + +++ +
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE-R 1712
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
A L L+ + +++ + + + KK + D
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-------ECRNAEEKAKKAITDAAMM 1765
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDV 1058
E+ K S K +E+ I +++ +L + + K +LQ A+++++
Sbjct: 1766 AEEL---KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1822
Query: 1059 NAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LE ++ A K + + E+ KN
Sbjct: 1823 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1860
Score = 64.1 bits (149), Expect = 5e-09
Identities = 155/870 (17%), Positives = 341/870 (39%), Gaps = 78/870 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ +L ++ + + + L+ + ++QA S L+++L++ L
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA-LGSQLQKKLKELQARIEELE 1119
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQR 494
+L+ ++E+ +++ ++L EI + ++ ++ E+ + E +++R
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L EA + + +L K S+ G Q D L+ ++ LE+E E
Sbjct: 1177 DLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS--E 1223
Query: 555 QLRNAEEETANCKQ-VNPPTFLDKQVMT----DNIVTCDIHESETVTNSI--QNKMIHAA 607
++ T+N +Q + L+K T N E++ N + Q +
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNLRKTAARVEEDNESLL 665
+ S++ + L T + + L L + + A N A + + LL
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 666 LQLKKMATKARSRKLSPTPPANK--LSIETANDNDE-KETDEADPAEMKLLLELNEQEAT 722
+ + T+A++ AN T + D + T+E + A+ KL L E E
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 723 V--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE--- 1455
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++ +
Sbjct: 1456 -WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDL 1512
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
++ LE ++L+ E +LQ + ++ +L+ K + + E +
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQ----SALEEAEASLEHEEGKILRAQLEFNQI 1568
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
A+I E ++ +DE+ E +A + + S Q +
Sbjct: 1569 KAEI-ERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1621
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L + + Q S R+ + LQ +++D + ++ + V N L +
Sbjct: 1622 LNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAIVE 1675
Query: 1021 TK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+ L+ E++E+R+ + + + + + E+ + + L N+ K ++
Sbjct: 1676 RRNNLLQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 1731
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ S L + + +E +N E + K D
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761
>AY518538-1|AAT44534.1| 1179|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.7B protein.
Length = 1179
Score = 99 bits (238), Expect = 8e-20
Identities = 162/837 (19%), Positives = 342/837 (40%), Gaps = 71/837 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 348 LQKKLKELQARIEELEEELEAERTARAKVEKLRSD-LSRELEEISERLEEAGGATSVQIE 406
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 407 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 464
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQ +E+ S E ++++ + L+ +
Sbjct: 465 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND---LTSQQ 521
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+EV +A LQ
Sbjct: 522 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 581
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 582 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRTKYETDAIQRTEELEEAKKKLA 638
Query: 551 D-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L+E E A C + + + D +V D+ S ++ K +
Sbjct: 639 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 696
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 697 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 754
Query: 663 SLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL T K+ A K+ +++A + E + + ++ LE N+ +A
Sbjct: 755 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 814
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ R+ E+ E+ ++A + ++ + S +TS + T +R K+
Sbjct: 815 EIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETRSRNEALRVKKKM------- 862
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 863 -EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 917
Query: 840 IEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ ++L+A+ + L A E+ + E + ++ + + L S +N KK +++
Sbjct: 918 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK--KMD 975
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + +++E C++ + + K T+A + LK +Q
Sbjct: 976 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1034
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K + +L+ +E + E M+ +
Sbjct: 1035 KDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEAEQKRNAESVKGMRKSERRI 1091
Query: 1015 KEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE+T +T +L+ +D+++ K+ + + + T ++K + V +L+
Sbjct: 1092 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1148
Score = 83.0 bits (196), Expect = 1e-14
Identities = 190/1032 (18%), Positives = 396/1032 (38%), Gaps = 71/1032 (6%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +A K + +L+ S+ + +L+ ++ + QE + L+ + Q+ E DN E
Sbjct: 90 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-EQDN-LADAEE 147
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE-KKVRFTE 924
+ QL+KN L + K ++N + + E E AK ++LE C + K + + T
Sbjct: 148 RCDQLIKNKIQLEA-KVKEMNERLEDEEEMNA-ELTAKKRKLEDECSELKRDIDDLELTL 205
Query: 925 A-TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
A +KE ++K + L+ A + K T
Sbjct: 206 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 265
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
K++L++ V+DLE + + V + + +++ KL +E I +ND + +
Sbjct: 266 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE--SIMDL--ENDKQQLD 321
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
E RL+ + +L +NA++E ++ + + K L+ + + + L E R A++ K
Sbjct: 322 E--RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR-AKVEK 378
Query: 1104 LSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKLLK 1161
L +DL + + + + ++ T + + L K
Sbjct: 379 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 438
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
+ D ++G+ ++ + + D VT + T
Sbjct: 439 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 498
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
E S+ +E Q S+ L+ E +L + K + K + +QLED
Sbjct: 499 QMNEHRSKAEETQRSVNDLTSQQAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 558
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
RQ +E + + +E AK +L++ S A E
Sbjct: 559 LKRQLE----EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSE 611
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+AQ ++ K E + +A+E + ++ L++ + +
Sbjct: 612 VAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 668
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+++ ++ L++ K + E KQ+YEE+ +LE S ++ EL
Sbjct: 669 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 728
Query: 1462 YELLEE--EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
EE EH+ T R E + Q E+ + ++L ++ I L EK+ + A EK
Sbjct: 729 KNAYEESLEHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQLEA---EK 781
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDVLEHHH----DXX 1573
E+Q+++ + L ++ RA+L N + ER+L ++ + + +H D
Sbjct: 782 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 841
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTR- 1632
+ RV K ++ K+ ++ + DT+ +
Sbjct: 842 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 901
Query: 1633 ----------------YEGQMNTMRDELKSLHNQVSRFRRERDNYKQ-MLEAAQKSMAEI 1675
E + N ++ EL+ L V + R R +Q ++E +++ ++
Sbjct: 902 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER--VQL 959
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE----LCESRLLASKLNTE--- 1728
+ ++ I++ D + + +V Q+ E++ + ++ ++A +L E
Sbjct: 960 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1019
Query: 1729 ---LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
L K + E + ++Q RL+E E+ L G+ ++ L R+ ++ EQ+R
Sbjct: 1020 SAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1078
Query: 1786 QETSTLARDLRQ 1797
+ + + R+
Sbjct: 1079 ESVKGMRKSERR 1090
Score = 74.9 bits (176), Expect = 3e-12
Identities = 191/1082 (17%), Positives = 411/1082 (37%), Gaps = 82/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 103 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 158
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 159 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----RDIDDLELTLAKVEKEK 212
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 213 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 263
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + +ER
Sbjct: 264 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 323
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 324 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 383
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 384 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 443
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 444 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 503
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 504 RSKAEETQRSVND--LTSQQAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 560
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 561 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 618
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 619 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 678
Query: 1128 XXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 679 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 738
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 739 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 798
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 799 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 858
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 859 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 918
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K + +L SER + L + K DA+L
Sbjct: 919 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 978
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 979 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1038
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1039 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1096
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1097 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1156
Query: 1566 LE 1567
E
Sbjct: 1157 AE 1158
Score = 72.5 bits (170), Expect = 1e-11
Identities = 237/1189 (19%), Positives = 464/1189 (39%), Gaps = 146/1189 (12%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + +L+ L +E +EL ++ + +E DL
Sbjct: 79 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 138
Query: 406 QDNFR--EDQADEYSSLRRELEQTIK--NCRV---------LSFKLKKTERKADQLEQEK 452
QDN E++ D+ + +LE +K N R+ L+ K +K E + +L+++
Sbjct: 139 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 198
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E+ +L +E + L
Sbjct: 199 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-- 254
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E +R L A+ + ++
Sbjct: 255 --QAEEDKVN--TLTKAKVKLE--QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 308
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ +D + ++ + + ++ K + + E + + K +E Q
Sbjct: 309 SIMDLE-----------NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 357
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
+ + + A R A+VE+ L +L+++ S +L A + IE
Sbjct: 358 RIE----ELEEELEAE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSVQIE 406
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSK 748
N E E + + L+ +E A LR+K V EL + + L++ VK+ K
Sbjct: 407 M-NKKREAEFQKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEK 463
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS 808
S K T+ + L E+ + LED+++E R K E +R +L+
Sbjct: 464 EKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVN----DLT 518
Query: 809 LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL-RAK---TQSLEADNEKLQTE 864
Q K +T +N +L RQL E S L R K TQ LE +L+ E
Sbjct: 519 SQQAKLQT------------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 566
Query: 865 NKKLQLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
K L +A +S R D DL + Q E E EA A+++ + E ++ +
Sbjct: 567 VKAKNALAHALQSARHD--CDLLRE---QYEEET-EAKAELQRVLSKANSEVAQWR---- 616
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
TK ETD ++ + + L +A+++ + K +
Sbjct: 617 --TKYETDAIQRTEELEEA---------------KKKLAQRLQEAEEAVEAVNAKCSSLE 659
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
TK +L+ +EDL ++ NA + + + +K + E + K ++ SE +
Sbjct: 660 KTKHRLQNEIEDLMVDVER-----SNAAAAALDKKQRN-FDKILAEWKQKYEESQSELES 713
Query: 1044 ---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
E L TE+ KLK NA E + + EN NL + LTE++ +
Sbjct: 714 SQKEARSLSTELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKT 766
Query: 1101 INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLL 1160
I++L K + + + + Q+ K ++
Sbjct: 767 IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---------KAEIE 817
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+++ +K +++ + ++ + +R + + + L++ +
Sbjct: 818 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 877
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R++ E + LQ+ T+ I L+ +R D + I +E +++L
Sbjct: 878 -RMAAEAQKQVKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEEL 932
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+ QT + +E E R Q + +A + +TE E + +
Sbjct: 933 RAVVEQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 991
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
A+ K+ K S++ E K ++ ++ + +LD A
Sbjct: 992 CRNAEEKA--KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQ 1046
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+K +L L+ +++ LE A KR E + ++K E +++ Y+
Sbjct: 1047 IALKGGKKQLQKLEARVRELENELEAEQKR----NAESVKGMRKSER--RIKELTYQTEE 1100
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ LL + +V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 1101 DRKNLLRLQDLVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 1147
Score = 69.3 bits (162), Expect = 1e-10
Identities = 173/878 (19%), Positives = 365/878 (41%), Gaps = 91/878 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRSSE 318
+++ D +EG ++ +R ER +++ + D+ L + + +D N + + E
Sbjct: 271 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 330
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L ++ + L+ + K L +I E+E ELE + A ++E+LR+
Sbjct: 331 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA---KVEKLRS------ 381
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKN-CRVLSF 436
+L E E++ + L + +Q + + E+ +RR+LE+ T+++ +
Sbjct: 382 ----DLSRELEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 436
Query: 437 KLKKTERKADQLEQ-EKAEHEKKLLEIVGGPDGMQRENRIKELEQEV---ARSTEVALRL 492
+ K + A+ EQ + + K+ LE ++ ++ +EQ + A ++ L
Sbjct: 437 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 496
Query: 493 QRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLERE 549
+ ++ E SK + S+ + Q ++ L+R +++ +QL R ++
Sbjct: 497 EDQMNEHRSKAEETQRSVNDLTSQQAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 556
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
DL+ QL EEE K N + D + + +E ET + +++ A++
Sbjct: 557 EDLKRQL---EEEV---KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 610
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPY--------LSIFNHMAANNLRKTAARVEEDN 661
++ ++ +I +T E + L + N ++L KT R++ +
Sbjct: 611 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN-AKCSSLEKTKHRLQNEI 669
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQE 720
E L++ +++ + A + +K+ E +E +++ E+ E + L E
Sbjct: 670 EDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----STE 724
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
L+ EE + E K++ K L +IS +T+ GS+ L +L E+++
Sbjct: 725 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKME 783
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QLQV 839
L+ ++E L +E + L A+L Q K + R L D++ KR L+V
Sbjct: 784 -LQSALEEAEASLEHEEG--KILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLRV 837
Query: 840 IEQEASVLRAKTQS----------LEAD-NE---KLQTENK-KLQLLKNAKSLRS-DKAL 883
++ + L A+T+S +E D NE +L N+ + K KSL+S K
Sbjct: 838 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 897
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK--VRFTEATKK--ETDTLKSKQXX 939
+ + ++LKE +A ++ + Q E E + V TE ++K E + +++ +
Sbjct: 898 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE-R 956
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
A L L+ + +++ + + + KK + D
Sbjct: 957 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-------ECRNAEEKAKKAITDAAMM 1009
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDV 1058
E+ K S K +E+ I +++ +L + + K +LQ A+++++
Sbjct: 1010 AEEL---KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1066
Query: 1059 NAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LE ++ A K + + E+ KN
Sbjct: 1067 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1104
Score = 64.1 bits (149), Expect = 5e-09
Identities = 155/870 (17%), Positives = 341/870 (39%), Gaps = 78/870 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 185 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 244
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 245 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 304
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ +L ++ + + + L+ + ++QA S L+++L++ L
Sbjct: 305 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA-LGSQLQKKLKELQARIEELE 363
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQR 494
+L+ ++E+ +++ ++L EI + ++ ++ E+ + E +++R
Sbjct: 364 EELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKMRR 420
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L EA + + +L K S+ G Q D L+ ++ LE+E E
Sbjct: 421 DLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS--E 467
Query: 555 QLRNAEEETANCKQ-VNPPTFLDKQVMT----DNIVTCDIHESETVTNSI--QNKMIHAA 607
++ T+N +Q + L+K T N E++ N + Q +
Sbjct: 468 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQQAKLQTE 527
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNLRKTAARVEEDNESLL 665
+ S++ + L T + + L L + + A N A + + LL
Sbjct: 528 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 587
Query: 666 LQLKKMATKARSRKLSPTPPANK--LSIETANDNDE-KETDEADPAEMKLLLELNEQEAT 722
+ + T+A++ AN T + D + T+E + A+ KL L E E
Sbjct: 588 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 647
Query: 723 V--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 648 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE--- 699
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++ +
Sbjct: 700 -WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDL 756
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
++ LE ++L+ E +LQ + ++ +L+ K + + E +
Sbjct: 757 TEQLGSSGKTIHELEKVRKQLEAEKMELQ----SALEEAEASLEHEEGKILRAQLEFNQI 812
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
A+I E ++ +DE+ E +A + + S Q +
Sbjct: 813 KAEI-ERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 865
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L + + Q S R+ + LQ +++D + ++ + V N L +
Sbjct: 866 LNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAIVE 919
Query: 1021 TK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+ L+ E++E+R+ + + + + + E+ + + L N+ K ++
Sbjct: 920 RRNNLLQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 975
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ S L + + +E +N E + K D
Sbjct: 976 ADLSQLQTEVEEAVQECRNAEEKAKKAITD 1005
>AB209708-1|BAD92945.1| 1574|Homo sapiens myosin, heavy polypeptide 7,
cardiac muscle, beta variant protein.
Length = 1574
Score = 99 bits (238), Expect = 8e-20
Identities = 162/837 (19%), Positives = 342/837 (40%), Gaps = 71/837 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 743 LQKKLKELQARIEELEEELEAERTARAKVEKLRSD-LSRELEEISERLEEAGGATSVQIE 801
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 802 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 859
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQ +E+ S E ++++ + L+ +
Sbjct: 860 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND---LTSQR 916
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+EV +A LQ
Sbjct: 917 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 976
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 977 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRTKYETDAIQRTEELEEAKKKLA 1033
Query: 551 D-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L+E E A C + + + D +V D+ S ++ K +
Sbjct: 1034 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 1091
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 1092 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 1149
Query: 663 SLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL T K+ A K+ +++A + E + + ++ LE N+ +A
Sbjct: 1150 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1209
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ R+ E+ E+ ++A + ++ + S +TS + T +R K+
Sbjct: 1210 EIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETRSRNEALRVKKKM------- 1257
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 1258 -EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1312
Query: 840 IEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ ++L+A+ + L A E+ + E + ++ + + L S +N KK +++
Sbjct: 1313 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK--KMD 1370
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + +++E C++ + + K T+A + LK +Q
Sbjct: 1371 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1429
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K + +L+ +E + E M+ +
Sbjct: 1430 KDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEAEQKRNAESVKGMRKSERRI 1486
Query: 1015 KEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE+T +T +L+ +D+++ K+ + + + T ++K + V +L+
Sbjct: 1487 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1543
Score = 83.0 bits (196), Expect = 1e-14
Identities = 190/1032 (18%), Positives = 396/1032 (38%), Gaps = 71/1032 (6%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +A K + +L+ S+ + +L+ ++ + QE + L+ + Q+ E DN E
Sbjct: 485 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-EQDN-LADAEE 542
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE-KKVRFTE 924
+ QL+KN L + K ++N + + E E AK ++LE C + K + + T
Sbjct: 543 RCDQLIKNKIQLEA-KVKEMNERLEDEEEMNA-ELTAKKRKLEDECSELKRDIDDLELTL 600
Query: 925 A-TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
A +KE ++K + L+ A + K T
Sbjct: 601 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 660
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
K++L++ V+DLE + + V + + +++ KL +E I +ND + +
Sbjct: 661 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE--SIMDL--ENDKQQLD 716
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
E RL+ + +L +NA++E ++ + + K L+ + + + L E R A++ K
Sbjct: 717 E--RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR-AKVEK 773
Query: 1104 LSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKLLK 1161
L +DL + + + + ++ T + + L K
Sbjct: 774 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 833
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
+ D ++G+ ++ + + D VT + T
Sbjct: 834 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 893
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
E S+ +E Q S+ L+ E +L + K + K + +QLED
Sbjct: 894 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 953
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
RQ +E + + +E AK +L++ S A E
Sbjct: 954 LKRQLE----EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSE 1006
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+AQ ++ K E + +A+E + ++ L++ + +
Sbjct: 1007 VAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1063
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+++ ++ L++ K + E KQ+YEE+ +LE S ++ EL
Sbjct: 1064 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1123
Query: 1462 YELLEE--EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
EE EH+ T R E + Q E+ + ++L ++ I L EK+ + A EK
Sbjct: 1124 KNAYEESLEHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQLEA---EK 1176
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDVLEHHH----DXX 1573
E+Q+++ + L ++ RA+L N + ER+L ++ + + +H D
Sbjct: 1177 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 1236
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTR- 1632
+ RV K ++ K+ ++ + DT+ +
Sbjct: 1237 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1296
Query: 1633 ----------------YEGQMNTMRDELKSLHNQVSRFRRERDNYKQ-MLEAAQKSMAEI 1675
E + N ++ EL+ L V + R R +Q ++E +++ ++
Sbjct: 1297 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER--VQL 1354
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE----LCESRLLASKLNTE--- 1728
+ ++ I++ D + + +V Q+ E++ + ++ ++A +L E
Sbjct: 1355 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1414
Query: 1729 ---LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
L K + E + ++Q RL+E E+ L G+ ++ L R+ ++ EQ+R
Sbjct: 1415 SAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1473
Query: 1786 QETSTLARDLRQ 1797
+ + + R+
Sbjct: 1474 ESVKGMRKSERR 1485
Score = 75.4 bits (177), Expect = 2e-12
Identities = 191/1082 (17%), Positives = 411/1082 (37%), Gaps = 82/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 498 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 553
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 554 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----RDIDDLELTLAKVEKEK 607
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 608 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 658
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + +ER
Sbjct: 659 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 718
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 719 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 778
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 779 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 838
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 839 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 898
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 899 RSKAEETQRSVND--LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 955
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 956 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1013
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 1014 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1073
Query: 1128 XXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 1074 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1133
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 1134 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1193
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 1194 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1253
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 1254 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1313
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K + +L SER + L + K DA+L
Sbjct: 1314 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1373
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 1374 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1433
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1434 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1491
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1492 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1551
Query: 1566 LE 1567
E
Sbjct: 1552 AE 1553
Score = 70.9 bits (166), Expect = 4e-11
Identities = 236/1189 (19%), Positives = 464/1189 (39%), Gaps = 146/1189 (12%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + +L+ L +E +EL ++ + +E DL
Sbjct: 474 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 533
Query: 406 QDNFR--EDQADEYSSLRRELEQTIK--NCRV---------LSFKLKKTERKADQLEQEK 452
QDN E++ D+ + +LE +K N R+ L+ K +K E + +L+++
Sbjct: 534 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 593
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E+ +L +E + L
Sbjct: 594 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-- 649
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E +R L A+ + ++
Sbjct: 650 --QAEEDKVN--TLTKAKVKLE--QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 703
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ +D + ++ + + ++ K + + E + + K +E Q
Sbjct: 704 SIMDLE-----------NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 752
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
+ + + A R A+VE+ L +L+++ S +L A + IE
Sbjct: 753 RIE----ELEEELEAE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSVQIE 801
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSK 748
N E E + + L+ +E A LR+K V EL + + L++ VK+ K
Sbjct: 802 M-NKKREAEFQKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEK 858
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS 808
S K T+ + L E+ + LED+++E R K E +R +L+
Sbjct: 859 EKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVN----DLT 913
Query: 809 LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL-RAK---TQSLEADNEKLQTE 864
+ K +T +N +L RQL E S L R K TQ LE +L+ E
Sbjct: 914 SQRAKLQT------------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 961
Query: 865 NKKLQLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
K L +A +S R D DL + Q E E EA A+++ + E ++ +
Sbjct: 962 VKAKNALAHALQSARHD--CDLLRE---QYEEET-EAKAELQRVLSKANSEVAQWR---- 1011
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
TK ETD ++ + + L +A+++ + K +
Sbjct: 1012 --TKYETDAIQRTEELEEA---------------KKKLAQRLQEAEEAVEAVNAKCSSLE 1054
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
TK +L+ +EDL ++ NA + + + +K + E + K ++ SE +
Sbjct: 1055 KTKHRLQNEIEDLMVDVER-----SNAAAAALDKKQRN-FDKILAEWKQKYEESQSELES 1108
Query: 1044 ---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
E L TE+ KLK NA E + + EN NL + LTE++ +
Sbjct: 1109 SQKEARSLSTELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKT 1161
Query: 1101 INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLL 1160
I++L K + + + + Q+ K ++
Sbjct: 1162 IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---------KAEIE 1212
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+++ +K +++ + ++ + +R + + + L++ +
Sbjct: 1213 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1272
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R++ E + LQ+ T+ I L+ +R D + I +E +++L
Sbjct: 1273 -RMAAEAQKQVKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEEL 1327
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+ QT + +E E R Q + +A + +TE E + +
Sbjct: 1328 RAVVEQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1386
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
A+ K+ K S++ E K ++ ++ + +LD A
Sbjct: 1387 CRNAEEKA--KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQ 1441
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+K +L L+ +++ LE A KR E + ++K E +++ Y+
Sbjct: 1442 IALKGGKKQLQKLEARVRELENELEAEQKR----NAESVKGMRKSER--RIKELTYQTEE 1495
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ LL + +V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 1496 DRKNLLRLQDLVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 1542
Score = 68.9 bits (161), Expect = 2e-10
Identities = 173/878 (19%), Positives = 365/878 (41%), Gaps = 91/878 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRSSE 318
+++ D +EG ++ +R ER +++ + D+ L + + +D N + + E
Sbjct: 666 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 725
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L ++ + L+ + K L +I E+E ELE + A ++E+LR+
Sbjct: 726 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA---KVEKLRS------ 776
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKN-CRVLSF 436
+L E E++ + L + +Q + + E+ +RR+LE+ T+++ +
Sbjct: 777 ----DLSRELEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 831
Query: 437 KLKKTERKADQLEQ-EKAEHEKKLLEIVGGPDGMQRENRIKELEQEV---ARSTEVALRL 492
+ K + A+ EQ + + K+ LE ++ ++ +EQ + A ++ L
Sbjct: 832 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 891
Query: 493 QRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLERE 549
+ ++ E SK + S+ + Q ++ L+R +++ +QL R ++
Sbjct: 892 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 951
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
DL+ QL EEE K N + D + + +E ET + +++ A++
Sbjct: 952 EDLKRQL---EEEV---KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1005
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPY--------LSIFNHMAANNLRKTAARVEEDN 661
++ ++ +I +T E + L + N ++L KT R++ +
Sbjct: 1006 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN-AKCSSLEKTKHRLQNEI 1064
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQE 720
E L++ +++ + A + +K+ E +E +++ E+ E + L E
Sbjct: 1065 EDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----STE 1119
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
L+ EE + E K++ K L +IS +T+ GS+ L +L E+++
Sbjct: 1120 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKME 1178
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QLQV 839
L+ ++E L +E + L A+L Q K + R L D++ KR L+V
Sbjct: 1179 -LQSALEEAEASLEHEEG--KILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLRV 1232
Query: 840 IEQEASVLRAKTQS----------LEAD-NE---KLQTENK-KLQLLKNAKSLRS-DKAL 883
++ + L A+T+S +E D NE +L N+ + K KSL+S K
Sbjct: 1233 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1292
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK--VRFTEATKK--ETDTLKSKQXX 939
+ + ++LKE +A ++ + Q E E + V TE ++K E + +++ +
Sbjct: 1293 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE-R 1351
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
A L L+ + +++ + + + KK + D
Sbjct: 1352 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-------ECRNAEEKAKKAITDAAMM 1404
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDV 1058
E+ K S K +E+ I +++ +L + + K +LQ A+++++
Sbjct: 1405 AEEL---KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1461
Query: 1059 NAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LE ++ A K + + E+ KN
Sbjct: 1462 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1499
Score = 64.1 bits (149), Expect = 5e-09
Identities = 155/870 (17%), Positives = 341/870 (39%), Gaps = 78/870 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 580 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 639
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 640 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 699
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ +L ++ + + + L+ + ++QA S L+++L++ L
Sbjct: 700 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA-LGSQLQKKLKELQARIEELE 758
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQR 494
+L+ ++E+ +++ ++L EI + ++ ++ E+ + E +++R
Sbjct: 759 EELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKMRR 815
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L EA + + +L K S+ G Q D L+ ++ LE+E E
Sbjct: 816 DLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS--E 862
Query: 555 QLRNAEEETANCKQ-VNPPTFLDKQVMT----DNIVTCDIHESETVTNSI--QNKMIHAA 607
++ T+N +Q + L+K T N E++ N + Q +
Sbjct: 863 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 922
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNLRKTAARVEEDNESLL 665
+ S++ + L T + + L L + + A N A + + LL
Sbjct: 923 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 982
Query: 666 LQLKKMATKARSRKLSPTPPANK--LSIETANDNDE-KETDEADPAEMKLLLELNEQEAT 722
+ + T+A++ AN T + D + T+E + A+ KL L E E
Sbjct: 983 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1042
Query: 723 V--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1043 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE--- 1094
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++ +
Sbjct: 1095 -WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDL 1151
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
++ LE ++L+ E +LQ + ++ +L+ K + + E +
Sbjct: 1152 TEQLGSSGKTIHELEKVRKQLEAEKMELQ----SALEEAEASLEHEEGKILRAQLEFNQI 1207
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
A+I E ++ +DE+ E +A + + S Q +
Sbjct: 1208 KAEI-ERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1260
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L + + Q S R+ + LQ +++D + ++ + V N L +
Sbjct: 1261 LNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAIVE 1314
Query: 1021 TK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+ L+ E++E+R+ + + + + + E+ + + L N+ K ++
Sbjct: 1315 RRNNLLQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 1370
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ S L + + +E +N E + K D
Sbjct: 1371 ADLSQLQTEVEEAVQECRNAEEKAKKAITD 1400
>M58018-1|AAA62830.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 99.5 bits (237), Expect = 1e-19
Identities = 162/837 (19%), Positives = 342/837 (40%), Gaps = 71/837 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 1104 LQKKLKELQARIEELEEELESERTARAKVEKLRSD-LSRELEEISERLEEAGGATSVQIE 1162
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 1163 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQ +E+ S E ++++ + L+ +
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND---LTSQR 1277
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+EV +A LQ
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1337
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRTKYETDAIQRTEELEEAKKKLA 1394
Query: 551 D-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L+E E A C + + + D +V D+ S ++ K +
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 1452
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 1510
Query: 663 SLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL T K+ A K+ +++A + E + + ++ LE N+ +A
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ R+ E+ E+ ++A + ++ + S +TS + T +R K+
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETRSRNEALRVKKKM------- 1618
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 1619 -EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 840 IEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ ++L+A+ + L A E+ + E + ++ + + L S +N KK +++
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK--KMD 1731
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + +++E C++ + + K T+A + LK +Q
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1790
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K + +L+ +E + E M+ +
Sbjct: 1791 KDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEAEQKRNAESVKGMRKSERRI 1847
Query: 1015 KEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE+T +T +L+ +D+++ K+ + + + T ++K + V +L+
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Score = 83.4 bits (197), Expect = 7e-15
Identities = 190/1032 (18%), Positives = 396/1032 (38%), Gaps = 71/1032 (6%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +A K + +L+ S+ + +L+ ++ + QE + L+ + Q+ E DN E
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-EQDN-LADAEE 903
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE-KKVRFTE 924
+ QL+KN L + K ++N + + E E AK ++LE C + K + + T
Sbjct: 904 RCDQLIKNKIQLEA-KVKEMNERLEDEEEMNA-ELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 925 A-TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
A +KE ++K + L+ A + K T
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
K++L++ V+DLE + + V + + +++ KL +E I +ND + +
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE--SIMDL--ENDKQQLD 1077
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
E RL+ + +L +NA++E ++ + + K L+ + + + L E R A++ K
Sbjct: 1078 E--RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTAR-AKVEK 1134
Query: 1104 LSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKLLK 1161
L +DL + + + + ++ T + + L K
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
+ D ++G+ ++ + + D VT + T
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
E S+ +E Q S+ L+ E +L + K + K + +QLED
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
RQ +E + + +E AK +L++ S A E
Sbjct: 1315 LKRQLE----EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSE 1367
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+AQ ++ K E + +A+E + ++ L++ + +
Sbjct: 1368 VAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+++ ++ L++ K + E KQ+YEE+ +LE S ++ EL
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 1462 YELLEE--EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
EE EH+ T R E + Q E+ + ++L ++ I L EK+ + A EK
Sbjct: 1485 KNAYEESLEHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQLEA---EK 1537
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDVLEHHH----DXX 1573
E+Q+++ + L ++ RA+L N + ER+L ++ + + +H D
Sbjct: 1538 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 1597
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTR- 1632
+ RV K ++ K+ ++ + DT+ +
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Query: 1633 ----------------YEGQMNTMRDELKSLHNQVSRFRRERDNYKQ-MLEAAQKSMAEI 1675
E + N ++ EL+ L V + R R +Q ++E +++ ++
Sbjct: 1658 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER--VQL 1715
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE----LCESRLLASKLNTE--- 1728
+ ++ I++ D + + +V Q+ E++ + ++ ++A +L E
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1775
Query: 1729 ---LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
L K + E + ++Q RL+E E+ L G+ ++ L R+ ++ EQ+R
Sbjct: 1776 SAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834
Query: 1786 QETSTLARDLRQ 1797
+ + + R+
Sbjct: 1835 ESVKGMRKSERR 1846
Score = 74.9 bits (176), Expect = 3e-12
Identities = 191/1082 (17%), Positives = 411/1082 (37%), Gaps = 82/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 859 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 914
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 915 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----RDIDDLELTLAKVEKEK 968
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 1019
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + +ER
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTARAKVEKLRSDL 1139
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 1140 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 1260 RSKAEETQRSVND--LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 1316
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 1317 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1374
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 1128 XXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K + +L SER + L + K DA+L
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1852
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1853 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1912
Query: 1566 LE 1567
E
Sbjct: 1913 AE 1914
Score = 69.3 bits (162), Expect = 1e-10
Identities = 173/878 (19%), Positives = 366/878 (41%), Gaps = 91/878 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRSSE 318
+++ D +EG ++ +R ER +++ + D+ L + + +D N + + E
Sbjct: 1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 1086
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L ++ + L+ + K L +I E+E ELE+ + A ++E+LR+
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTARA---KVEKLRS------ 1137
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKN-CRVLSF 436
+L E E++ + L + +Q + + E+ +RR+LE+ T+++ +
Sbjct: 1138 ----DLSRELEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 437 KLKKTERKADQLEQ-EKAEHEKKLLEIVGGPDGMQRENRIKELEQEV---ARSTEVALRL 492
+ K + A+ EQ + + K+ LE ++ ++ +EQ + A ++ L
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 493 QRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLERE 549
+ ++ E SK + S+ + Q ++ L+R +++ +QL R ++
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
DL+ QL EEE K N + D + + +E ET + +++ A++
Sbjct: 1313 EDLKRQL---EEEV---KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPY--------LSIFNHMAANNLRKTAARVEEDN 661
++ ++ +I +T E + L + N ++L KT R++ +
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN-AKCSSLEKTKHRLQNEI 1425
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQE 720
E L++ +++ + A + +K+ E +E +++ E+ E + L E
Sbjct: 1426 EDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----STE 1480
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
L+ EE + E K++ K L +IS +T+ GS+ L +L E+++
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKME 1539
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QLQV 839
L+ ++E L +E + L A+L Q K + R L D++ KR L+V
Sbjct: 1540 -LQSALEEAEASLEHEEG--KILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLRV 1593
Query: 840 IEQEASVLRAKTQS----------LEAD-NE---KLQTENK-KLQLLKNAKSLRS-DKAL 883
++ + L A+T+S +E D NE +L N+ + K KSL+S K
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK--VRFTEATKK--ETDTLKSKQXX 939
+ + ++LKE +A ++ + Q E E + V TE ++K E + +++ +
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE-R 1712
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
A L L+ + +++ + + + KK + D
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-------ECRNAEEKAKKAITDAAMM 1765
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDV 1058
E+ K S K +E+ I +++ +L + + K +LQ A+++++
Sbjct: 1766 AEEL---KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1822
Query: 1059 NAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LE ++ A K + + E+ KN
Sbjct: 1823 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1860
Score = 67.7 bits (158), Expect = 4e-10
Identities = 225/1179 (19%), Positives = 457/1179 (38%), Gaps = 126/1179 (10%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + +L+ L +E +EL ++ + +E DL
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG 465
QDN + A+E +Q IKN L K+K+ + + E+ AE K ++
Sbjct: 895 QDNLAD--AEE------RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 466 PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETV--KVSR 523
++R+ I +LE +A+ + + ++ + G + + K+ + + + +
Sbjct: 947 CSELKRD--IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
+L ++ED L + LE++ D L L ++ + ++ D ++ +
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIF 642
+I+ + ++ + + ++ K + + E + + K +E Q + +
Sbjct: 1065 SIMDLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIE----ELE 1119
Query: 643 NHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
+ + R A+VE+ L +L+++ S +L A + IE N E E
Sbjct: 1120 EELESE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSVQIEM-NKKREAEF 1171
Query: 703 DEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ + L+ +E A LR+K V EL + + L++ VK+ K S K
Sbjct: 1172 QKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEFKLELD 1229
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
T+ + L E+ + LED+++E R K E +R +L+ + K +T
Sbjct: 1230 DVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVN----DLTSQRAKLQT-- 1282
Query: 819 KSRSLDASDQQNVDLKRQLQVIEQEASVL-RAK---TQSLEADNEKLQTENKKLQLLKNA 874
+N +L RQL E S L R K TQ LE +L+ E K L +A
Sbjct: 1283 ----------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Query: 875 -KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTL 933
+S R D DL + Q E E EA A+++ + E ++ + TK ETD +
Sbjct: 1333 LQSARHD--CDLLRE---QYEEET-EAKAELQRVLSKANSEVAQWR------TKYETDAI 1380
Query: 934 KSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMV 993
+ + + L +A+++ + K + TK +L+ +
Sbjct: 1381 QRTEELEEA---------------KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI 1425
Query: 994 EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQT 1050
EDL ++ NA + + + +K + E + K ++ SE + E L T
Sbjct: 1426 EDLMVDVER-----SNAAAAALDKKQRN-FDKILAEWKQKYEESQSELESSQKEARSLST 1479
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
E+ KLK NA E + + EN NL + LTE++ + I++L K
Sbjct: 1480 ELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ 1532
Query: 1111 ATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
+ + + + Q+ K ++ +++ +K +++
Sbjct: 1533 LEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---------KAEIERKLAEKDEEM 1583
Query: 1171 GDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSE 1229
+ ++ + +R + + + L++ + R++ E +
Sbjct: 1584 EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN-RMAAEAQKQ 1642
Query: 1230 KDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
LQ+ T+ I L+ +R D + I +E +++L + QT
Sbjct: 1643 VKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1698
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
+ +E E R Q + +A + +TE E + + A+ K+
Sbjct: 1699 RKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKA-- 1755
Query: 1350 AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL 1409
K S++ E K ++ ++ + +LD A +K +L
Sbjct: 1756 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQIALKGGKKQL 1812
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
L+ +++ LE A KR E + ++K E +++ Y+ + LL +
Sbjct: 1813 QKLEARVRELENELEAEQKR----NAESVKGMRKSER--RIKELTYQTEEDRKNLLRLQD 1866
Query: 1470 VVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 1867 LVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 1903
Score = 64.5 bits (150), Expect = 4e-09
Identities = 155/870 (17%), Positives = 341/870 (39%), Gaps = 78/870 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ +L ++ + + + L+ + ++QA S L+++L++ L
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA-LGSQLQKKLKELQARIEELE 1119
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQR 494
+L+ ++E+ +++ ++L EI + ++ ++ E+ + E +++R
Sbjct: 1120 EELESERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L EA + + +L K S+ G Q D L+ ++ LE+E E
Sbjct: 1177 DLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS--E 1223
Query: 555 QLRNAEEETANCKQ-VNPPTFLDKQVMT----DNIVTCDIHESETVTNSI--QNKMIHAA 607
++ T+N +Q + L+K T N E++ N + Q +
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNLRKTAARVEEDNESLL 665
+ S++ + L T + + L L + + A N A + + LL
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 666 LQLKKMATKARSRKLSPTPPANK--LSIETANDNDE-KETDEADPAEMKLLLELNEQEAT 722
+ + T+A++ AN T + D + T+E + A+ KL L E E
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 723 V--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE--- 1455
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++ +
Sbjct: 1456 -WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDL 1512
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
++ LE ++L+ E +LQ + ++ +L+ K + + E +
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQ----SALEEAEASLEHEEGKILRAQLEFNQI 1568
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
A+I E ++ +DE+ E +A + + S Q +
Sbjct: 1569 KAEI-ERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1621
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L + + Q S R+ + LQ +++D + ++ + V N L +
Sbjct: 1622 LNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAIVE 1675
Query: 1021 TK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+ L+ E++E+R+ + + + + + E+ + + L N+ K ++
Sbjct: 1676 RRNNLLQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 1731
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ S L + + +E +N E + K D
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761
>M57965-1|AAA51837.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 99.5 bits (237), Expect = 1e-19
Identities = 162/837 (19%), Positives = 342/837 (40%), Gaps = 71/837 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 1104 LQKKLKELQARIEELEEELESERTARAKVEKLRSD-LSRELEEISERLEEAGGATSVQIE 1162
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 1163 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQ +E+ S E ++++ + L+ +
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND---LTSQR 1277
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+EV +A LQ
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1337
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRTKYETDAIQRTEELEEAKKKLA 1394
Query: 551 D-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L+E E A C + + + D +V D+ S ++ K +
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 1452
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 1510
Query: 663 SLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL T K+ A K+ +++A + E + + ++ LE N+ +A
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ R+ E+ E+ ++A + ++ + S +TS + T +R K+
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETRSRNEALRVKKKM------- 1618
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 1619 -EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 840 IEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ ++L+A+ + L A E+ + E + ++ + + L S +N KK +++
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK--KMD 1731
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + +++E C++ + + K T+A + LK +Q
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1790
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K + +L+ +E + E M+ +
Sbjct: 1791 KDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEAEQKRNAESVKGMRKSERRI 1847
Query: 1015 KEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE+T +T +L+ +D+++ K+ + + + T ++K + V +L+
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Score = 83.4 bits (197), Expect = 7e-15
Identities = 190/1032 (18%), Positives = 396/1032 (38%), Gaps = 71/1032 (6%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +A K + +L+ S+ + +L+ ++ + QE + L+ + Q+ E DN E
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-EQDN-LADAEE 903
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE-KKVRFTE 924
+ QL+KN L + K ++N + + E E AK ++LE C + K + + T
Sbjct: 904 RCDQLIKNKIQLEA-KVKEMNERLEDEEEMNA-ELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 925 A-TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
A +KE ++K + L+ A + K T
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
K++L++ V+DLE + + V + + +++ KL +E I +ND + +
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE--SIMDL--ENDKQQLD 1077
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
E RL+ + +L +NA++E ++ + + K L+ + + + L E R A++ K
Sbjct: 1078 E--RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTAR-AKVEK 1134
Query: 1104 LSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKLLK 1161
L +DL + + + + ++ T + + L K
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
+ D ++G+ ++ + + D VT + T
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
E S+ +E Q S+ L+ E +L + K + K + +QLED
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
RQ +E + + +E AK +L++ S A E
Sbjct: 1315 LKRQLE----EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSE 1367
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+AQ ++ K E + +A+E + ++ L++ + +
Sbjct: 1368 VAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+++ ++ L++ K + E KQ+YEE+ +LE S ++ EL
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 1462 YELLEE--EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
EE EH+ T R E + Q E+ + ++L ++ I L EK+ + A EK
Sbjct: 1485 KNAYEESLEHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQLEA---EK 1537
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDVLEHHH----DXX 1573
E+Q+++ + L ++ RA+L N + ER+L ++ + + +H D
Sbjct: 1538 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 1597
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTR- 1632
+ RV K ++ K+ ++ + DT+ +
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Query: 1633 ----------------YEGQMNTMRDELKSLHNQVSRFRRERDNYKQ-MLEAAQKSMAEI 1675
E + N ++ EL+ L V + R R +Q ++E +++ ++
Sbjct: 1658 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER--VQL 1715
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE----LCESRLLASKLNTE--- 1728
+ ++ I++ D + + +V Q+ E++ + ++ ++A +L E
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1775
Query: 1729 ---LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
L K + E + ++Q RL+E E+ L G+ ++ L R+ ++ EQ+R
Sbjct: 1776 SAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834
Query: 1786 QETSTLARDLRQ 1797
+ + + R+
Sbjct: 1835 ESVKGMRKSERR 1846
Score = 74.9 bits (176), Expect = 3e-12
Identities = 191/1082 (17%), Positives = 411/1082 (37%), Gaps = 82/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 859 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 914
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 915 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----RDIDDLELTLAKVEKEK 968
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 1019
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + +ER
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTARAKVEKLRSDL 1139
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 1140 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 1260 RSKAEETQRSVND--LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 1316
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 1317 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1374
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 1128 XXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K + +L SER + L + K DA+L
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1852
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1853 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1912
Query: 1566 LE 1567
E
Sbjct: 1913 AE 1914
Score = 69.3 bits (162), Expect = 1e-10
Identities = 173/878 (19%), Positives = 366/878 (41%), Gaps = 91/878 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRSSE 318
+++ D +EG ++ +R ER +++ + D+ L + + +D N + + E
Sbjct: 1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 1086
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ L ++ + L+ + K L +I E+E ELE+ + A ++E+LR+
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTARA---KVEKLRS------ 1137
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKN-CRVLSF 436
+L E E++ + L + +Q + + E+ +RR+LE+ T+++ +
Sbjct: 1138 ----DLSRELEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 437 KLKKTERKADQLEQ-EKAEHEKKLLEIVGGPDGMQRENRIKELEQEV---ARSTEVALRL 492
+ K + A+ EQ + + K+ LE ++ ++ +EQ + A ++ L
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 493 QRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLERE 549
+ ++ E SK + S+ + Q ++ L+R +++ +QL R ++
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
DL+ QL EEE K N + D + + +E ET + +++ A++
Sbjct: 1313 EDLKRQL---EEEV---KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPY--------LSIFNHMAANNLRKTAARVEEDN 661
++ ++ +I +T E + L + N ++L KT R++ +
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN-AKCSSLEKTKHRLQNEI 1425
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQE 720
E L++ +++ + A + +K+ E +E +++ E+ E + L E
Sbjct: 1426 EDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----STE 1480
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
L+ EE + E K++ K L +IS +T+ GS+ L +L E+++
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKME 1539
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QLQV 839
L+ ++E L +E + L A+L Q K + R L D++ KR L+V
Sbjct: 1540 -LQSALEEAEASLEHEEG--KILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLRV 1593
Query: 840 IEQEASVLRAKTQS----------LEAD-NE---KLQTENK-KLQLLKNAKSLRS-DKAL 883
++ + L A+T+S +E D NE +L N+ + K KSL+S K
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK--VRFTEATKK--ETDTLKSKQXX 939
+ + ++LKE +A ++ + Q E E + V TE ++K E + +++ +
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE-R 1712
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
A L L+ + +++ + + + KK + D
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-------ECRNAEEKAKKAITDAAMM 1765
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDV 1058
E+ K S K +E+ I +++ +L + + K +LQ A+++++
Sbjct: 1766 AEEL---KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 1822
Query: 1059 NAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LE ++ A K + + E+ KN
Sbjct: 1823 ENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1860
Score = 67.7 bits (158), Expect = 4e-10
Identities = 225/1179 (19%), Positives = 457/1179 (38%), Gaps = 126/1179 (10%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + +L+ L +E +EL ++ + +E DL
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG 465
QDN + A+E +Q IKN L K+K+ + + E+ AE K ++
Sbjct: 895 QDNLAD--AEE------RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 466 PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETV--KVSR 523
++R+ I +LE +A+ + + ++ + G + + K+ + + + +
Sbjct: 947 CSELKRD--IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
+L ++ED L + LE++ D L L ++ + ++ D ++ +
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIF 642
+I+ + ++ + + ++ K + + E + + K +E Q + +
Sbjct: 1065 SIMDLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIE----ELE 1119
Query: 643 NHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
+ + R A+VE+ L +L+++ S +L A + IE N E E
Sbjct: 1120 EELESE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSVQIEM-NKKREAEF 1171
Query: 703 DEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ + L+ +E A LR+K V EL + + L++ VK+ K S K
Sbjct: 1172 QKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEFKLELD 1229
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
T+ + L E+ + LED+++E R K E +R +L+ + K +T
Sbjct: 1230 DVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVN----DLTSQRAKLQT-- 1282
Query: 819 KSRSLDASDQQNVDLKRQLQVIEQEASVL-RAK---TQSLEADNEKLQTENKKLQLLKNA 874
+N +L RQL E S L R K TQ LE +L+ E K L +A
Sbjct: 1283 ----------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Query: 875 -KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTL 933
+S R D DL + Q E E EA A+++ + E ++ + TK ETD +
Sbjct: 1333 LQSARHD--CDLLRE---QYEEET-EAKAELQRVLSKANSEVAQWR------TKYETDAI 1380
Query: 934 KSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMV 993
+ + + L +A+++ + K + TK +L+ +
Sbjct: 1381 QRTEELEEA---------------KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI 1425
Query: 994 EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQT 1050
EDL ++ NA + + + +K + E + K ++ SE + E L T
Sbjct: 1426 EDLMVDVER-----SNAAAAALDKKQRN-FDKILAEWKQKYEESQSELESSQKEARSLST 1479
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
E+ KLK NA E + + EN NL + LTE++ + I++L K
Sbjct: 1480 ELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ 1532
Query: 1111 ATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
+ + + + Q+ K ++ +++ +K +++
Sbjct: 1533 LEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---------KAEIERKLAEKDEEM 1583
Query: 1171 GDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSE 1229
+ ++ + +R + + + L++ + R++ E +
Sbjct: 1584 EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN-RMAAEAQKQ 1642
Query: 1230 KDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
LQ+ T+ I L+ +R D + I +E +++L + QT
Sbjct: 1643 VKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1698
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
+ +E E R Q + +A + +TE E + + A+ K+
Sbjct: 1699 RKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKA-- 1755
Query: 1350 AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL 1409
K S++ E K ++ ++ + +LD A +K +L
Sbjct: 1756 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQIALKGGKKQL 1812
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
L+ +++ LE A KR E + ++K E +++ Y+ + LL +
Sbjct: 1813 QKLEARVRELENELEAEQKR----NAESVKGMRKSER--RIKELTYQTEEDRKNLLRLQD 1866
Query: 1470 VVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 1867 LVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 1903
Score = 64.5 bits (150), Expect = 4e-09
Identities = 155/870 (17%), Positives = 341/870 (39%), Gaps = 78/870 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ +L ++ + + + L+ + ++QA S L+++L++ L
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA-LGSQLQKKLKELQARIEELE 1119
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQR 494
+L+ ++E+ +++ ++L EI + ++ ++ E+ + E +++R
Sbjct: 1120 EELESERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L EA + + +L K S+ G Q D L+ ++ LE+E E
Sbjct: 1177 DLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS--E 1223
Query: 555 QLRNAEEETANCKQ-VNPPTFLDKQVMT----DNIVTCDIHESETVTNSI--QNKMIHAA 607
++ T+N +Q + L+K T N E++ N + Q +
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNLRKTAARVEEDNESLL 665
+ S++ + L T + + L L + + A N A + + LL
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 666 LQLKKMATKARSRKLSPTPPANK--LSIETANDNDE-KETDEADPAEMKLLLELNEQEAT 722
+ + T+A++ AN T + D + T+E + A+ KL L E E
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 723 V--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE--- 1455
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++ +
Sbjct: 1456 -WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDL 1512
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
++ LE ++L+ E +LQ + ++ +L+ K + + E +
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQ----SALEEAEASLEHEEGKILRAQLEFNQI 1568
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
A+I E ++ +DE+ E +A + + S Q +
Sbjct: 1569 KAEI-ERKLAEKDEEME------QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1621
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L + + Q S R+ + LQ +++D + ++ + V N L +
Sbjct: 1622 LNEM--EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAIVE 1675
Query: 1021 TK---LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+ L+ E++E+R+ + + + + + E+ + + L N+ K ++
Sbjct: 1676 RRNNLLQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 1731
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ S L + + +E +N E + K D
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761
>Z15005-1|CAA78727.1| 2663|Homo sapiens CENP-E protein.
Length = 2663
Score = 99.1 bits (236), Expect = 1e-19
Identities = 259/1344 (19%), Positives = 528/1344 (39%), Gaps = 133/1344 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++++++ YQ Q+E K+ L K + E + + + ++
Sbjct: 665 MENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITD 724
Query: 322 LQQKVNELTTHNEDLRDEK------KHLTQKIREIESELETRPST-EAQTRQIEQLRAKL 374
LQ+++N+ NE LR+E K L ++ + E++ + T + ++L +++
Sbjct: 725 LQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEV 784
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFRE------DQADEYSSLRRELEQTI 428
+ E+ + L++E K +L F+ D +Y + E E+
Sbjct: 785 VHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMN 844
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEV 488
+ LS + +K + L+ E + ++L E + +R N +++L++++
Sbjct: 845 QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTR--EVQERLNEMEQLKEQLENRDSP 902
Query: 489 ALRLQRELAEANSKFTGSNPSLMKVPQP-ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
++RE K + + + Q + +K + SL Q + QL D+ D++
Sbjct: 903 LQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESL-----QIERDQLKSDIHDTVN 957
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAA 607
D +EQLRNA E L + T N + I SE V+ ++ +
Sbjct: 958 MNIDTQEQLRNALES------------LKQHQETINTLKSKI--SEEVSRNLHME----E 999
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQ 667
+T +K++ + IDK + + + ++ RK + ++E NE LQ
Sbjct: 1000 NTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE---LQ 1056
Query: 668 LKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-LELNEQEATVLRR 726
+ A +L N IE +N E E++LL EL +Q+ V +
Sbjct: 1057 QMLESVIAEKEQLKTDLKEN---IEMTIENQE---------ELRLLGDELKKQQEIVAQE 1104
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
K ++++ E L + L +++ K + ++ L +++E + K+ +EI
Sbjct: 1105 KNHAIKKEGE-LSRTCDRL-AEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI--NEI 1160
Query: 787 DEVRKKLIEKERDCERLHAE-LSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ ++ +L KE E + E L LAQK + + +S+ + ++ V LK + E E
Sbjct: 1161 ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI--TKERKV-LKELQKSFETERD 1217
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN--ELKEALAK 903
LR + +EA + + E K + D+ ++KT Q+ N +L+++ K
Sbjct: 1218 HLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTK 1277
Query: 904 IKELEMICQDEK----SEKKVRFTEATKKETDTL--KSKQXXXXXXXXXXXXXXXXXXXX 957
++E + +E+ + KKV T+ T E + L +S
Sbjct: 1278 LQEEIPVLHEEQELLPNVKKVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337
Query: 958 QATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEM 1017
Q + + +K ++ + K+ ++ QLK+ + + +I E + + ++
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVKHD-QLKEHIRETLAKIQESQSKQEQSLNMKEKD 1396
Query: 1018 TAKTKLEKEIDEIRSK---LSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK 1074
TK+ E+++ + K L + + E RLQ ++K V AK +KD +
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV-AK---EKDDLQRLQE 1452
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLK----NATSLQTTMSDCMXXXXXXXX 1130
L++E+ L K + + E ++ LK L+ +S+
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512
Query: 1131 XXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQ 1190
++ Y K +Q K + EV + ++ + IE +
Sbjct: 1513 QLEAINDKLQNKIQEI--YEKEEQLNIKQISEVQENVNELKQFKEHRKAKDSALQSIESK 1570
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQARFIKTESK---F 1244
+ +R+ + + L IE L E+ A+ +++ K F
Sbjct: 1571 MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQF 1630
Query: 1245 ITLEA---------EMRDLKADYENKITSLESTIAAKDVHIKQL----EDALRQTTNDKY 1291
+ + A E+ LK +E + +LE+ I +++ + Q+ + +R T ++
Sbjct: 1631 LKMTAVNETQEKMCEIEHLKEQFETQKLNLEN-IETENIRLTQILHENLEEMRSVTKERD 1689
Query: 1292 D----EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKS 1347
D E T VE +++ Q+EL + L+ E + + KL +
Sbjct: 1690 DLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK--EHQETIDKLR-GIVSE 1746
Query: 1348 DLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-IAHDKDVK--N 1404
++ N + + + L+ +++ +D++R I +K K N
Sbjct: 1747 KTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSN 1806
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKL-----------EHSLALEKA 1453
+L KL+ Q A ++ LK++ ET KK+ + SL L K
Sbjct: 1807 MQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKL 1866
Query: 1454 EYEELTGKYEL---LEEEHVVTKARLTVEKEQAQGELLHVQK-ELSTALGEIKTLQEKLG 1509
E E L EL LEE V K R + + + E L +++ +L +L E K ++
Sbjct: 1867 EIENLNLAQELHENLEEMKSVMKERDNLRRVE---ETLKLERDQLKESLQETKARDLEIQ 1923
Query: 1510 TESAAWNTEKTEMQNSIASLQERL 1533
E E + ++ L+E++
Sbjct: 1924 QELKTARMLSKEHKETVDKLREKI 1947
Score = 93.1 bits (221), Expect = 9e-18
Identities = 279/1542 (18%), Positives = 612/1542 (39%), Gaps = 136/1542 (8%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRA--KL 374
SE+ L+ + L E LR EK+ + K++E +++L+ + E +T++ ++++ ++
Sbjct: 498 SELNSLRADYDNLVLDYEQLRTEKEEMELKLKE-KNDLDEFEALERKTKKDQEMQLIHEI 556
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ----ADEYSSLRRELE---QT 427
+ L + N+D++ EL +D ++ Q + + +++ +L ++
Sbjct: 557 SNLKNLVKHREVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLES 616
Query: 428 IKNCRVLSFKLKKTE-------RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQ 480
I++ + + L E R++ L E E ++K+ E+ Q EN I+ +
Sbjct: 617 IEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELA--TTYKQMENDIQLYQS 674
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
++ ++ + L++EL A ++ T SL+ P+ + + G + +L +
Sbjct: 675 QLEAKKKMQVDLEKELQSAFNEITKLT-SLIDGKVPKDLLCNLE--LEGKITDLQKELNK 731
Query: 541 DLQDS--LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMT---DNIVTCDIHESETV 595
+++++ L E L +L++ E ++ + ++T D + + +H+ V
Sbjct: 732 EVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRV 791
Query: 596 TNSIQN--KMIHAASTPSSKEKSDSPPLSIDKTTE---ETQFHFDLPYLSIFNHMAANNL 650
++ K +T S KS KT E ++ L N N L
Sbjct: 792 QGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN-L 850
Query: 651 RKTAARVEEDNESLLLQL--KKMATKARSRKLSPT-PPANKLSIETANDNDEKETDEADP 707
K A + + +L +L K + ++R++ +L + N + +T E +
Sbjct: 851 SKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSPLQTVEREK 910
Query: 708 AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSL 767
+ L+ +E L ++ ++L+Q +E+L+ + +L S I + + R +L
Sbjct: 911 TLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNAL 970
Query: 768 TTNSNKLAEERVKVLEDEI-DEVRKKLIEKERDCE---RLHAELSLAQKKPKTLIKSR-- 821
S K +E + L+ +I +EV + L +E E ++ KK K+
Sbjct: 971 --ESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQT 1028
Query: 822 -SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK-LQL-LKNAKSLR 878
+ D D + ++ +R++ + QE + L+ +S+ A+ E+L+T+ K+ +++ ++N + LR
Sbjct: 1029 LTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELR 1088
Query: 879 SDKALDLNTKKTTQL-ENELKEALAKIKELEMICQ-----DEKSEKKVRFTEATKKETDT 932
L KK ++ E A+ K EL C +EK ++K + + +++
Sbjct: 1089 ---LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN 1145
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDD----AQKSFKPRIPKKPTDLTTKLQ 988
++ + + TL+ ++ + AQK + K K+
Sbjct: 1146 VQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV- 1204
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL--------EKEIDEIRSKLSKNDSE 1040
LK++ + E E + ++ +G + + K+ ++ IDE+R +S+ ++
Sbjct: 1205 LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ 1264
Query: 1041 FTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA- 1099
N ++ L+ KL++ L ++++ N K E + + N+ + LTE+ +++
Sbjct: 1265 IINTQD-LEKSHTKLQEEIPVLHEEQELLPNVKKVSETQET--MNELELLTEQSTTKDST 1321
Query: 1100 -----QINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQ 1154
++ +L + K S + S + KI +
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQE 1381
Query: 1155 DKNKL-----LKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXX 1209
++K +KE ++T KI RIE ++ R+
Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVA 1441
Query: 1210 XQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA---DYENKITSLE 1266
+ L +RL L SE D+L+ + +K + E E++ + E I L
Sbjct: 1442 KEKDDL----QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497
Query: 1267 STIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKI 1326
++ K+ I ++ L + NDK + E + Q+ +N K
Sbjct: 1498 VNLSEKETEISTIQKQL-EAINDKLQNKIQEIYEKEEQLNIKQISEV----QENVNELKQ 1552
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQS 1386
E +A+ SA + ++S + +L N + + L + +
Sbjct: 1553 FKEHRKAKDSA----LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIE-RD 1607
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
+ K+ + +A K+ + K+ + + + E+ I LK+++E LE+
Sbjct: 1608 QLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC-----EIEHLKEQFETQKLNLEN 1662
Query: 1447 SLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKE-LSTALGEIKTLQ 1505
+ E ++ +E LEE VTK R + + E L V+++ L L E T
Sbjct: 1663 -IETENIRLTQIL--HENLEEMRSVTKERDDLRSVE---ETLKVERDQLKENLRETITRD 1716
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDV 1565
+ E + E Q +I L+ G E+ + +++L +ND
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLR------GIVSEKTN---EISNMQKDLEHSNDALKA 1767
Query: 1566 LEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAE 1625
+ E + K++ +E S + +
Sbjct: 1768 QDLK--IQEELRIAHMHLKEQQETIDKLR----GIVSEKTDKLSNMQKDLENSNAKLQEK 1821
Query: 1626 ITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH 1685
I + K E Q+ T++ ++ +VS + + K ++ S EI+N + + +H
Sbjct: 1822 IQELKAN-EHQLITLKKDVNETQKKVSEMEQLKKQIKD--QSLTLSKLEIENLNLAQELH 1878
Query: 1686 RNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQS 1745
N + R+ + +E+ + D+L ES + E+ E +A + E +
Sbjct: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKE 1938
Query: 1746 RLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQE 1787
+++ E+ +S +++ + ++ K +DE Q+ +QE
Sbjct: 1939 TVDKLREK--ISEKTIQISDIQKDLD----KSKDELQKKIQE 1974
Score = 91.5 bits (217), Expect = 3e-17
Identities = 195/1094 (17%), Positives = 406/1094 (37%), Gaps = 60/1094 (5%)
Query: 694 ANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT 753
+N D E +PA L E E E LR + L D E L+ + +E+ K+
Sbjct: 473 SNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKN 532
Query: 754 ----------KTSAGSNTTARRSLTTNSNKLAEERV--KVLEDEIDEVRKKLIEKERDCE 801
KT ++ N + V + LE+E+ + L EKE +
Sbjct: 533 DLDEFEALERKTKKDQEMQLIHEISNLKNLVKHREVYNQDLENELSSKVELLREKEDQIK 592
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
+L + + + + S SL++ + +K+ L + E L AK +S +E L
Sbjct: 593 KLQEYIDSQKLENIKMDLSYSLESIEDPK-QMKQTL--FDAETVALDAKRESAFLRSENL 649
Query: 862 QTENKKLQLLKNAKSLRSDKAL---DLNTKKTTQ--LENELKEALAKIKELEMICQDEKS 916
+ + K +L K + +D L L KK Q LE EL+ A +I +L + +
Sbjct: 650 ELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVP 709
Query: 917 EKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRI 976
+ + E K TD K + LKSL + ++ + I
Sbjct: 710 KDLLCNLELEGKITDLQKELNKEVEENEALREEVILL-----SELKSLPSEVER-LRKEI 763
Query: 977 PKKPTDLTTKLQLK-KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLS 1035
K +L K K+ ++ + + +++ G + ++ K D+
Sbjct: 764 QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823
Query: 1036 KNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+F + + E ++ L + F + AL+ E S + + + T E++
Sbjct: 824 TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQ 883
Query: 1096 NREAQINKLSADLKNATS-LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQ 1154
R ++ +L L+N S LQT + +
Sbjct: 884 ERLNEMEQLKEQLENRDSPLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI 943
Query: 1155 DKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVV 1214
++++L ++ D D K+ ++ ++T K +++
Sbjct: 944 ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGE 1003
Query: 1215 LANTHRRLSIELTSEKDELQARFIKT------ESKFITLEAEMRDLKADYENKITSLEST 1268
+ ++ + + +K +L+A+ +T +++ I + ++ L + LES
Sbjct: 1004 TKDEFQQKMVGI-DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESV 1062
Query: 1269 IAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
IA K+ L++ + T ++ + E+ + + + EL+ +L
Sbjct: 1063 IAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRL 1122
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
+ E + ++ + + L ++ + +NK L+ +++ER
Sbjct: 1123 AEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE-HMETER 1181
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
+L + + ++VK+ E LK K E I E++ +T ++L+ +
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241
Query: 1449 ALEKAEYEELTGKYELLEEE--HVVTKARLTVEKEQAQGEL--LHVQKELSTALGEIKTL 1504
K E + + E+ ++ L + Q E+ LH ++EL + ++
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKKVSET 1301
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
QE + T+ ++A + E+ER RLN + + + E+++ RD
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARI---------EMERLRLNEKFQESQEEIKSLTKERD 1352
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
L+ + E ++KIQ SE +
Sbjct: 1353 NLKTIKEALEVKHDQLKEHIR--ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFK 1410
Query: 1625 EITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARI 1684
R E +M + L+ H+++ +E+D+ +++ E Q ++K K I
Sbjct: 1411 PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK--EI 1468
Query: 1685 HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
+ + EEE + L++Q E+ + E R+ S+ TE+ + + E ++Q
Sbjct: 1469 VAKHLET--EEELKVAHCCLKEQ----EETINELRVNLSEKETEISTIQKQLEAINDKLQ 1522
Query: 1745 SRLNE-YEEERLLS 1757
+++ E YE+E L+
Sbjct: 1523 NKIQEIYEKEEQLN 1536
Score = 84.6 bits (200), Expect = 3e-15
Identities = 239/1320 (18%), Positives = 530/1320 (40%), Gaps = 116/1320 (8%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
E + +I L++E L K E E + +++L L+ + + E+ ++++
Sbjct: 717 ELEGKITDLQKE---LNKEVEENEALREEVIL--LSELKSLPSEVERLRKEIQDKSEELH 771
Query: 328 ELTTHNEDLRDEKKH-------LTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLAAET 379
+T+ + L E H L ++I + + +L T S T Q + + + E
Sbjct: 772 IITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ 831
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ +++ENE M +E+ +L + + E S +EL++ R + +L
Sbjct: 832 KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKT-ELSYKTQELQE---KTREVQERLN 887
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRE-NRIKELEQEV--ARSTEVALRLQREL 496
+ E+ +QLE + + E + +Q+ +K L QE + + +L+++R+
Sbjct: 888 EMEQLKEQLENRDSPLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
+++ T + M + E ++ + SL + QE L + + + R + E
Sbjct: 948 LKSDIHDTVN----MNIDTQEQLRNALESLKQ--HQETINTLKSKISEEVSRNLHMEENT 1001
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS------IQNK-----MIH 605
++E K V D + +T D+ ++E + IQ K M+
Sbjct: 1002 GETKDEFQQ-KMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLE 1060
Query: 606 AASTPSSKEKSD---SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ + K+D + ++I+ E +L N+ K + +
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD 1120
Query: 663 SLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPA--EMK---LLLELN 717
L +K+ K +S++L L+++ +K+ +E + E+K L LE
Sbjct: 1121 RLAEVEEKL--KEKSQQLQEKQQ-QLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHM 1177
Query: 718 EQEATVLRRKVEELEQDKEALKKQ---VKELTSKISSVTKTSAG--SNTTARRSLTTNSN 772
E E L +K+ E ++ +++ K+ +KEL + G A T
Sbjct: 1178 ETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEEL 1237
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKE------RDCERLHA----ELSLAQKKPKTL--IKS 820
K+A +K ++ IDE+R+ + EK +D E+ H E+ + ++ + L +K
Sbjct: 1238 KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKK 1297
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAKSLRS 879
S ++L + + ++ R + + L NEK Q ++++ L K +L++
Sbjct: 1298 VSETQETMNELELLTEQSTTKDSTTLARIEMERLRL-NEKFQESQEEIKSLTKERDNLKT 1356
Query: 880 DK-ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK--KETDTLKSK 936
K AL++ K QL+ ++E LAKI+E + Q++ K + E TK E + K K
Sbjct: 1357 IKEALEV---KHDQLKEHIRETLAKIQESQSK-QEQSLNMKEKDNETTKIVSEMEQFKPK 1412
Query: 937 QXXXXXXXXXXXXXXXXXXXXQATLKSL---KDDAQK------SFKPRIPKKPTDLTTK- 986
+KS+ KDD Q+ S ++ + ++ K
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 987 LQLKKMVEDLECEIGEMYVVMKN--AGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNE 1044
L+ ++ ++ C + E + LS KE T ++K+++ I KL E +
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEIST-IQKQLEAINDKLQNKIQEIYEK 1531
Query: 1045 KNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
+ +L I ++ +V + K F KA ++ ++ ++ LT ++ + +I +
Sbjct: 1532 EEQLN--IKQISEVQENVNELKQ-FKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Query: 1105 SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKL----- 1159
+ + +Q + Q T +++ + K+
Sbjct: 1589 IKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648
Query: 1160 LKEVGDKTKKIGDXXXXXXXXXXXC--KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLAN 1217
LKE + K + + +E+ S K+R + + N
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKEN 1708
Query: 1218 THRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK 1277
++ +L +++EL+ + + T++ ++R + ++ N+I++++ + + +K
Sbjct: 1709 LRETITRDL-EKQEELKIVHMHLKEHQETID-KLRGIVSEKTNEISNMQKDLEHSNDALK 1766
Query: 1278 QLEDALRQTTNDKYDEATSPVEMVE-MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
+ +++ + E ++ +R Q +L N+ KL++ E
Sbjct: 1767 AQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELK 1826
Query: 1337 AAKLEMAQLKSD-------LAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQ---S 1386
A + ++ LK D ++++E N A+EL +L+ S
Sbjct: 1827 ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKS 1886
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
K+ D +R ++ +K + +L + K + K L +E++ETV KL
Sbjct: 1887 VMKERDNLRRV-EETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945
Query: 1447 SLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQE 1506
++ + + ++ + ++E + K ++K++ Q LL V+++++ + +I +++
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDE--LQKKIQELQKKELQ--LLRVKEDVNMSHKKINEMEQ 2001
Score = 81.0 bits (191), Expect = 4e-14
Identities = 138/698 (19%), Positives = 304/698 (43%), Gaps = 65/698 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ +E Q++I+ L +E D L+ E +E K D L + + + + + L
Sbjct: 1333 LNEKFQESQEEIKSLTKERDNLKTIKEALEV-KHDQLKEHIRETLAKIQESQSKQEQSLN 1391
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIR-EIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+++K NE T ++ K + +R EIE L + +++ + + + L
Sbjct: 1392 MKEKDNETTKIVSEMEQFKPKDSALLRIEIEM-LGLSKRLQESHDEMKSVAKEKDDLQRL 1450
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR------EDQADEYSSLRRELEQTIKNCRVL 434
E L E++ +K+ ++++ ++ + ++Q + + LR L + +
Sbjct: 1451 QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI 1510
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+L+ K QE E E++L I + + N +K+ ++ ++
Sbjct: 1511 QKQLEAINDKLQNKIQEIYEKEEQL-NIKQISEVQENVNELKQFKEHRKAKDSALQSIES 1569
Query: 495 ELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLT--RGGSQEDPAQLLRDLQDSLEREAD 551
++ E ++ S + + + + E +K + +L R +E+ +++ +++S E+E
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629
Query: 552 LREQLRNAEEETANCKQVN-PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+ E + C+ + F +++ +NI T E+ +T + + S
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET----ENIRLTQILHENLEEMRSV- 1684
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+KE+ D ++ EET L + NLR+T R E E L ++
Sbjct: 1685 -TKERDDL------RSVEET--------LKVERDQLKENLRETITRDLEKQEEL--KIVH 1727
Query: 671 MATKARSRKLSPTPPANKLSIETAND--NDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
M K + + E N+ N +K+ + ++ A L++ E E + +
Sbjct: 1728 MHLKEHQETIDKL---RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE-ELRIAHMHL 1783
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR---RSLTTNSNKLAEERVKVLE-- 783
+E ++ + L+ V E T K+S++ K SN + + L N ++L + V E
Sbjct: 1784 KEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQ 1843
Query: 784 ---DEIDEVRKKLIEKERDCERLHAE-LSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
E+++++K++ ++ +L E L+LAQ+ + L + +S+ ++ N L+R +
Sbjct: 1844 KKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSV-MKERDN--LRRVEET 1900
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
++ E L+ Q +A + ++Q E K ++L DK + ++KT Q+ ++++
Sbjct: 1901 LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS-DIQK 1959
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
L K K ++ +KK++ E KKE L+ K+
Sbjct: 1960 DLDKSK--------DELQKKIQ--ELQKKELQLLRVKE 1987
Score = 59.7 bits (138), Expect = 1e-07
Identities = 159/875 (18%), Positives = 364/875 (41%), Gaps = 76/875 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
QI +++ V+ L++ E + + S + ++ N+ + + +++K E+
Sbjct: 1539 QISEVQENVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK-EEMKR 1597
Query: 332 HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ---IEQLRAKLLAAETLCEELMDEN 388
E L+ E+ L + +EI ++++ E Q + + + + K+ E L E+ +
Sbjct: 1598 VQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQK 1657
Query: 389 EDMKKELRDLXXXXXXMQDNFREDQA--DEYSSLRRELEQTIKNCR-VLSFKLKKT-ERK 444
+++ + + +N E ++ E LR +E+T+K R L L++T R
Sbjct: 1658 LNLENIETENIRLTQILHENLEEMRSVTKERDDLR-SVEETLKVERDQLKENLRETITRD 1716
Query: 445 ADQLEQEKAEHE--KKLLEIVGGPDGM--QRENRIKELEQEVARSTEVA----LRLQREL 496
++ E+ K H K+ E + G+ ++ N I +++++ S + L++Q EL
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
A+ ++ K+ + K + S + + A+L +Q+ E L
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH-ESETVTNSIQNKMIHAASTPSSKEK 615
++ E K+V+ L KQ+ ++ + E+ + + + S KE+
Sbjct: 1837 KDVNETQ---KKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSV--MKER 1891
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
+ + E Q L + L KTA + ++++ + +L++ ++
Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARDLEIQQEL-KTARMLSKEHKETVDKLREKISE- 1949
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
++ ++S + ++ + D +K+ E E++LL +++ + +K+ E+EQ
Sbjct: 1950 KTIQISDI----QKDLDKSKDELQKKIQELQKKELQLLRV--KEDVNMSHKKINEMEQ-- 2001
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR--KKL 793
LKKQ + + + K + LT ++ EE ++++ E DE+R K+
Sbjct: 2002 --LKKQFEP-----NYLCKCEMDN-----FQLTKKLHESLEE-IRIVAKERDELRRIKES 2048
Query: 794 IEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS 853
++ ERD +A+ + +K SD Q + ++ + ++ S ++ +
Sbjct: 2049 LKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQ----QHLMESLREKCSRIKELLKR 2104
Query: 854 LEADNEKLQTENK-KLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQ 912
++ + N+ L L K + R K L T+++ E E + K E++ I +
Sbjct: 2105 YSEMDDHYECLNRLSLDLEKEIEFHRIMKKLKYVLSYVTKIKEEQHECINKF-EMDFIDE 2163
Query: 913 DEKSEKKVRFTEATKKETDT-LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
EK ++ + + +++ D + + ++ S+K + Q+
Sbjct: 2164 VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQV 2223
Query: 972 FKPRIPKKPTD-----LTTKLQLKKMVEDLE------CEIGEMY----VVMKNAGLSGKE 1016
R K+ T L T+ ++K+ ++ C++ + + + N +E
Sbjct: 2224 LSNR--KEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEE 2281
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKD--VFANKYK 1074
+A E E D ++S KN+ F N + L+T +A VN + +K+ V + +
Sbjct: 2282 RSATISKEWEQD-LKSLKEKNEKLFKNYQT-LKTSLASGAQVNPTTQDNKNPHVTSRATQ 2339
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+ L N E ++E++I K+ +L+
Sbjct: 2340 LTTEKIRELENSLHEAKESAMHKESKIIKMQKELE 2374
Score = 44.0 bits (99), Expect = 0.006
Identities = 161/829 (19%), Positives = 313/829 (37%), Gaps = 74/829 (8%)
Query: 168 RVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKT-ARYKDERSSTKDDVNFLMQVK 226
R+ M L + Q + +K I E+ + + K+ E + A+ +++ K + + L+ +K
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXL-VDSNVKEYQDQIEGLKQEVDILRK 285
N T K L + + E ++++ + +E D LR+
Sbjct: 1837 KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKERDNLRR 1896
Query: 286 RCERVEKEKSDIL----------LRRLANIDTANKYTTGRSSEVLKLQQKVNELTTH--- 332
E ++ E+ + L + TA + V KL++K++E T
Sbjct: 1897 VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISD 1956
Query: 333 -NEDLRDEKKHLTQKIREIESE----LETRPSTEAQTRQIEQLRA--KLLAAETLCEELM 385
+DL K L +KI+E++ + L + ++I ++ K LC+ M
Sbjct: 1957 IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEPNYLCKCEM 2016
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
D + KK L ++ R++ SL+ E +Q I R + + +R+
Sbjct: 2017 DNFQLTKKLHESLEEIRIVAKE--RDELRRIKESLKMERDQFIATLREMIAR----DRQN 2070
Query: 446 DQLEQEK---AEHEKKLLEIVGGPDGMQRE--NRIKELEQEVARSTEVALRLQRELA--- 497
Q++ EK ++ ++ L+E + +E R E++ ++L L++E+
Sbjct: 2071 HQVKPEKRLLSDGQQHLMESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFHR 2130
Query: 498 -EANSKFTGSNPSLMKVPQPETV-KVSRSSLTRGGSQED--------------PAQLLRD 541
K+ S + +K Q E + K + Q++ P++ LRD
Sbjct: 2131 IMKKLKYVLSYVTKIKEEQHECINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD 2190
Query: 542 LQDSLEREADLREQLRN-AEEETANCKQVNPPTFLDKQVMTDNIVTC--DIHESETVTNS 598
L+ + + + E L++ +E E + K +++ MT + + E + N
Sbjct: 2191 LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG 2250
Query: 599 IQ--NKMIHAASTPSSKE----KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR- 651
IQ N I + + ++S T ++ DL L N N +
Sbjct: 2251 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2310
Query: 652 -KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
KT+ K +R+ +L+ T +L + E+ +M
Sbjct: 2311 LKTSLASGAQVNPTTQDNKNPHVTSRATQLT-TEKIRELENSLHEAKESAMHKESKIIKM 2369
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT- 769
+ LE+ L+ KV E + E K+ ++ L K++ K + L
Sbjct: 2370 QKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKI 2429
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAE-LSLAQKKPKTLIKSRSLDASDQ 828
+ K+ + K E EI K +E +++ RL E L +Q+ T + S D
Sbjct: 2430 DLEKM--KNAKEFEKEISAT-KATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPS 2486
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
I Q L K++ + + E + + + QL+K L S+ N
Sbjct: 2487 NKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEV 2546
Query: 889 KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
KT + E LK K ++ C++ KV T + KK+ + K+
Sbjct: 2547 KTWK-ERTLKREAHK----QVTCENSPKSPKVTGTASKKKQITPSQCKE 2590
>X69292-1|CAA49154.1| 881|Homo sapiens smooth muscle mysosin heavy
chain protein.
Length = 881
Score = 99.1 bits (236), Expect = 1e-19
Identities = 170/825 (20%), Positives = 340/825 (41%), Gaps = 87/825 (10%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQI-EQLRAKLLAAET 379
+L ++ + + +R+ + H++ +++SE R E Q R + E+L A E
Sbjct: 7 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 66
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ + E K +++ + + R +A + +R++ Q ++ L+ +L+
Sbjct: 67 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEA-QVQEMRQKHAQAVEE---LTEQLE 122
Query: 440 KTERKADQLEQEKAEHEKKLLEIVG-----GPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ +R L++ K EK+ ++ G G + E++ K+LE +V +R
Sbjct: 123 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 182
Query: 495 ELAEANSKF------TGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
AE N K S ++ + + +K+++ + +D +L LQ+ +
Sbjct: 183 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL---LQEETRQ 239
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
+ ++ +LR EEE + + KQ + +I T +I S++ + K+ AS
Sbjct: 240 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS-----KKKLQDFAS 294
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
T + E+ K E ++ A + L KT R++++ + L++ L
Sbjct: 295 TVEALEEGKK---RFQKEIENLTQQYE------EKAAAYDKLEKTKNRLQQELDDLVVDL 345
Query: 669 KKMA-----TKARSRKLSPTPPANK-LSIETANDNDEKETDEADPAEMKLLLELNEQEAT 722
+ + RK K +S + A++ D E + + L L +EA
Sbjct: 346 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA- 404
Query: 723 VLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVL 782
L K EELE+ + LK ++++L S V K + ++R+L T ++ + +++ L
Sbjct: 405 -LEAK-EELERTNKMLKAEMEDLVSSKDDVGK-NVHELEKSKRALETQMEEM-KTQLEEL 460
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD----LKRQLQ 838
EDE+ + E + + L + R L A D+QN + L+RQL
Sbjct: 461 EDELQATEDAKLRLEVNMQALKGQF------------ERDLQARDEQNEEKRRQLQRQLH 508
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
E E R + A +KL+ + K L+ L++D A+ K + +L+
Sbjct: 509 EYETELEDERKQRALAAAAKKKLEGDLKDLE-------LQADSAI----KGREEAIKQLR 557
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
+ A++K+ + +D ++ + F AT KE + K+K Q
Sbjct: 558 KLQAQMKDFQRELEDARASRDEIF--ATAKENEK-KAKSLEADLMQLQEDLAAAERARKQ 614
Query: 959 ATL--KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
A L + L ++ S R + + ++ ++ E+LE E G M + K
Sbjct: 615 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV---RKA 671
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD-KDVFANKYKA 1075
+L E+ RS KN+S + +L+ + +L+ ++EG K F + A
Sbjct: 672 TQQAEQLSNELATERSTAQKNES----SRQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 727
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
LE + + L Q + +E + ++A L K + + D
Sbjct: 728 LEAKIAQLEEQ---VEQEAREKQAATKSLKQKDKKLKEILLQVED 769
Score = 82.2 bits (194), Expect = 2e-14
Identities = 142/724 (19%), Positives = 285/724 (39%), Gaps = 54/724 (7%)
Query: 646 AANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEA 705
A NL K +E++N L +L+ + K KL + + E
Sbjct: 127 AKANLDKNKQTLEKENADLAGELRVLG----QAKQEVEHKKKKLEAQVQELQSKCSDGER 182
Query: 706 DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR 765
AE+ + + E + + E E L K V L+S++ T+ T +
Sbjct: 183 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD-TQELLQEETRQKL 241
Query: 766 SLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
+++T +L EER L+D++DE + ER L+ +LS ++KK + + +++A
Sbjct: 242 NVSTKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEA 298
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAKSLRSDKALD 884
++ +++++ + Q+ A LE +LQ E L + L N + L S+ L+
Sbjct: 299 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LE 356
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
+K QL E K +K + + E EK+ + + + L++K+
Sbjct: 357 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 416
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQ-LKKMVEDLECEI--- 1000
L S KDD K+ + K L T+++ +K +E+LE E+
Sbjct: 417 MLKAE--------MEDLVSSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQAT 467
Query: 1001 --GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDV 1058
++ + + L G+ +++ +E R +L + E+ E + + A
Sbjct: 468 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 527
Query: 1059 NAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTM 1118
KLEGD K LE + + + ++++ +AQ+ +L++A + + +
Sbjct: 528 KKKLEGD-------LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 580
Query: 1119 SDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTK-IDQDKNKLLKEVGDKTKKIGDXXXXX 1177
+ K D +K +L +E+
Sbjct: 581 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 640
Query: 1178 XXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIEL-TSEKDELQAR 1236
++E++L + + QA L+N L+ E T++K+E +
Sbjct: 641 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN---ELATERSTAQKNESSRQ 697
Query: 1237 FIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS 1296
++ ++K L +++ +++ ++K +STIAA + I QLE+ + Q +K S
Sbjct: 698 QLERQNK--ELRSKLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKS 752
Query: 1297 ------PVEMVEMRXXXXXXXXXXXXXQDELNNAKIK-----LEKTEAESSAAKLEMAQL 1345
++ + ++ Q E NA++K LE+ E ES +L
Sbjct: 753 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 812
Query: 1346 KSDL 1349
+ +L
Sbjct: 813 QREL 816
Score = 81.0 bits (191), Expect = 4e-14
Identities = 164/808 (20%), Positives = 332/808 (41%), Gaps = 61/808 (7%)
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQA--DEYSSLRRELEQTIKNCRV 433
A L +E+ +N +KK +R+L +Q++ ++A ++ +R+L + ++
Sbjct: 4 ALARLDDEIAQKNNALKK-IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE---A 59
Query: 434 LSFKLKKT-ERKADQLE-QEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
L +L+ T + A Q E + K E E +L+ + E +++E+ Q+ A++ E
Sbjct: 60 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE---- 115
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER-EA 550
EL E +F + +L K Q T++ + L G Q ++++ ++ EA
Sbjct: 116 ---ELTEQLEQFKRAKANLDKNKQ--TLEKENADLA--GELRVLGQAKQEVEHKKKKLEA 168
Query: 551 DLRE-QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET-VTNSIQNKMIHAAS 608
++E Q + ++ E A ++N DK N V ES T + N + K I A
Sbjct: 169 QVQELQSKCSDGERARA-ELN-----DKVHKLQNEV-----ESVTGMLNEAEGKAIKLAK 217
Query: 609 TPSS--KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL-RKTAARVEEDNESLL 665
+S + D+ L ++T ++ L L + + L + A+ +
Sbjct: 218 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 277
Query: 666 LQLKKMATKARSRKLSPTPPA---NKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT 722
L ++ +K + + + T A K + +N ++ +E A KL E+
Sbjct: 278 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL-----EKTKN 332
Query: 723 VLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVL 782
L++++++L D + ++ V L K + A + + AE R K
Sbjct: 333 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-- 390
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQ 842
E + + + L E E L + + + + L+ S+ D + +L++ + +E
Sbjct: 391 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSKRALET 448
Query: 843 EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA 902
+ + KTQ E ++E TE+ KL+L N ++L+ DL + Q E + ++
Sbjct: 449 QMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEEKRRQLQR 505
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
++ E E +DE+ ++ + K E D LK + QA +K
Sbjct: 506 QLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLRKLQAQMK 564
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
D Q+ + + T + +K + LE ++ ++ + A + K+ A +
Sbjct: 565 ----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ--ADLE 618
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ + +
Sbjct: 619 KEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 677
Query: 1083 LSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXX 1142
LSN+ T + E+ +L K S M +
Sbjct: 678 LSNELATERSTAQKNESSRQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEAKIAQL 735
Query: 1143 XXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 736 EEQVEQEAREKQAATKSLKQKDKKLKEI 763
Score = 80.2 bits (189), Expect = 7e-14
Identities = 170/866 (19%), Positives = 342/866 (39%), Gaps = 74/866 (8%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
++E + I L++++D R + EK+K D L L + T + T ++ +L+ K
Sbjct: 22 IRELEGHISDLQEDLDSERAARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAK 80
Query: 326 -VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
E+T + L +E + +++E+ + + E T Q+EQ + + + L
Sbjct: 81 REQEVTVLKKALDEETRSHEAQVQEMRQK--HAQAVEELTEQLEQFKRAKANLDKNKQTL 138
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
EN D+ ELR L ++ ++ +A + L+ + + L+ K+ K + +
Sbjct: 139 EKENADLAGELRVLGQAKQEVEHKKKKLEA-QVQELQSKCSDGERARAELNDKVHKLQNE 197
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGM--QRENRIKELEQEVARSTEVALRLQRELAEANSK 502
+ + E E K +++ + Q ++ + L++E + V+ +L R+L E +
Sbjct: 198 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL-RQLEEERNS 256
Query: 503 FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
M+ Q + R T D + L+D ++E L E + ++E
Sbjct: 257 LQDQLDEEMEAKQ----NLERHISTLNIQLSDSKKKLQDFASTVEA---LEEGKKRFQKE 309
Query: 563 TANCKQ--VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
N Q DK T N + E + + + N+ S K++
Sbjct: 310 IENLTQQYEEKAAAYDKLEKTKNRLQ---QELDDLVVDLDNQR-QLVSNLEKKQRKFDQL 365
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
L+ +K +I + A R A E++ ++L L +L
Sbjct: 366 LAEEK--------------NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 411
Query: 681 SPTPPANKLSIE---TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEA 737
T K +E ++ D+ K E + ++ L ++ E ++ ++EELE + +A
Sbjct: 412 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE-----MKTQLEELEDELQA 466
Query: 738 LKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKE 797
+ L + ++ K + AR + + ++ E E+++ RK+
Sbjct: 467 TEDAKLRLEVNMQAL-KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 525
Query: 798 RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD 857
++L +L + + + IK R + + +Q L+ Q++ ++E RA + A
Sbjct: 526 AAKKKLEGDLKDLELQADSAIKGR--EEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 583
Query: 858 NEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEKS 916
+ + E K L + L+ D A +K LE EL E LA QDEK
Sbjct: 584 AK--ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 641
Query: 917 EKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRI 976
+ R + ++ L+ +Q L + + AQK
Sbjct: 642 RLEARIAQLEEE----LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK------ 691
Query: 977 PKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSK 1036
+ +++ QL++ ++L ++ EM +K+ K + LE +I ++ ++ +
Sbjct: 692 -----NESSRQQLERQNKELRSKLHEMEGAVKS-----KFKSTIAALEAKIAQLEEQVEQ 741
Query: 1037 NDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
E L+ + KLK++ ++E D+ A +YK + + Q K EE +
Sbjct: 742 EAREKQAATKSLKQKDKKLKEILLQVE-DERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 800
Query: 1097 REAQIN----KLSADLKNATSLQTTM 1118
+IN KL +L AT M
Sbjct: 801 ESQRINANRRKLQRELDEATESNEAM 826
Score = 69.7 bits (163), Expect = 1e-10
Identities = 108/539 (20%), Positives = 223/539 (41%), Gaps = 38/539 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 335 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 392
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 393 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 452
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + E
Sbjct: 453 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 512
Query: 444 KADQLEQEKA---------EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ + +++A E + K LE+ RE IK+L + A+ + L+
Sbjct: 513 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 572
Query: 495 ELAEANSKFTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 573 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 632
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 633 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 691
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
SS+++ + + E + + S + A + + +VE++
Sbjct: 692 NESSRQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 750
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 751 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 807
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKISSVTKTS-AGSNTTARRSLTTNSNKLAEE 777
L+R+++E + EA+ ++V L SK+ +TS S + R + N++ EE
Sbjct: 808 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 866
Score = 56.0 bits (129), Expect = 1e-06
Identities = 73/318 (22%), Positives = 140/318 (44%), Gaps = 30/318 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSE 318
+ + +K++Q ++E + D + + EK+ + L++ ++ A + E
Sbjct: 559 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 618
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQ-------TRQIEQL 370
+L +++ + L+DEK+ L +I ++E EL E + + EA T+Q EQL
Sbjct: 619 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 678
Query: 371 RAKLLAAETLC---EELMDENEDMKKELRD-LXXXXXXMQDNFREDQA---DEYSSLRRE 423
+L + E + E KELR L ++ F+ A + + L +
Sbjct: 679 SNELATERSTAQKNESSRQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 738
Query: 424 LEQTIKNCRVLSFKLKKTERKADQL------EQEKAEHEKKLLEIVGGPDGMQRENRIKE 477
+EQ + + + LK+ ++K ++ E++ AE K+ E G Q + +++E
Sbjct: 739 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE-KGNARVKQLKRQLEE 797
Query: 478 LEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTR-GGSQEDPA 536
E+E R +LQREL EA T SN ++ + K+ R + T S+
Sbjct: 798 AEEESQRINANRRKLQRELDEA----TESNEAMGREVNALKSKLRRGNETSFVPSRRSGG 853
Query: 537 QLLRDLQDSLEREADLRE 554
+ + + D E E D R+
Sbjct: 854 RRVIENADGSEEETDTRD 871
Score = 55.6 bits (128), Expect = 2e-06
Identities = 109/625 (17%), Positives = 249/625 (39%), Gaps = 26/625 (4%)
Query: 262 VDSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKS--DILLRRLANIDTANKYTTGRSSE 318
+ S +++ Q+ + E +Q++++ K + E+ S D L + ++ + + +
Sbjct: 222 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 281
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST----EAQTRQIEQLRAKL 374
+ ++K+ + + E L + KK ++I + + E + + E +++Q L
Sbjct: 282 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 341
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +L+ E +++ L + N ADE E + L
Sbjct: 342 VVDLDNQRQLVSNLEKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL 397
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR-LQ 493
+ L++ ++LE+ + ++ ++V D + + + ELE+ R+ E + ++
Sbjct: 398 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHELEKS-KRALETQMEEMK 454
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL-EREADL 552
+L E + + + +++ + E + R LQ L E E +L
Sbjct: 455 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 514
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ R A K+ D ++ D+ + E+ +Q +M
Sbjct: 515 EDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQRELED 572
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--ESLLLQLK- 669
S + K E+ + + + +AA + A +E++ E L L
Sbjct: 573 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 632
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
+ A + R+L + +E N E +D A + +L+ + AT R +
Sbjct: 633 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNELATE-RSTAQ 690
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
+ E ++ L++Q KEL SK+ + + +L +L EE+V+ E
Sbjct: 691 KNESSRQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQAA 749
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
K L +K++ + + ++ ++K K ++ + + + LKRQL+ E+E+ + A
Sbjct: 750 TKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQLKRQLEEAEEESQRINA 807
Query: 850 KTQSLEADNEKLQTENKKLQLLKNA 874
+ L+ + ++ N+ + NA
Sbjct: 808 NRRKLQRELDEATESNEAMGREVNA 832
Score = 53.6 bits (123), Expect = 7e-06
Identities = 101/529 (19%), Positives = 209/529 (39%), Gaps = 47/529 (8%)
Query: 1265 LESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNA 1324
L++ +A D I Q +AL++ + + ++ R +EL
Sbjct: 1 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 60
Query: 1325 KIKLEKTEAESSAAKLEM-AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD 1383
K +LE T +S+A + E+ A+ + ++ L+ +A E +
Sbjct: 61 KTELEDT-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE---E 116
Query: 1384 LQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKK 1443
L + ++ R + DK+ + + E A L G+L++L G + + K++ E V++
Sbjct: 117 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLEAQVQE 172
Query: 1444 LEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKT 1503
L+ + + EL K L+ E L +A+G+ + + K++++ +++
Sbjct: 173 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLN----EAEGKAIKLAKDVASLSSQLQD 228
Query: 1504 LQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRR 1563
QE L E+ +K + + L+E ER N+ DQ + E+ A +
Sbjct: 229 TQELLQEETR----QKLNVSTKLRQLEE---------ER---NSLQDQLDEEMEAKQN-- 270
Query: 1564 DVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
LE H D+ S ++ E++ K
Sbjct: 271 --LERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 326
Query: 1624 AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE---------AAQKSMAE 1674
E TK R + +++ + +L + VS +++ + Q+L A ++ AE
Sbjct: 327 LE--KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 384
Query: 1675 IKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKS 1734
+ +K + + + + E + ++ + + ++L S+ K EL K
Sbjct: 385 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 444
Query: 1735 SAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQR 1783
+ E ++ EM+++L E E+E L ++ A++ L ERD Q R
Sbjct: 445 ALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQALKGQFERDLQAR 492
Score = 48.0 bits (109), Expect = 3e-04
Identities = 113/583 (19%), Positives = 212/583 (36%), Gaps = 42/583 (7%)
Query: 1211 QAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDL----------KADYEN 1260
Q + H + ELT + ++ + + TLE E DL K + E+
Sbjct: 102 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 161
Query: 1261 KITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDE 1320
K LE+ + E A R NDK + + VE V +
Sbjct: 162 KKKKLEAQVQELQSKCSDGERA-RAELNDKVHKLQNEVESVT--GMLNEAEGKAIKLAKD 218
Query: 1321 LNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKEL 1380
+ + +L+ T+ + + + L +LE E L
Sbjct: 219 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 278
Query: 1381 DTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG---AKRITELKQEY 1437
+ L +KKL + + K ++ + E+ + A K L+QE
Sbjct: 279 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 338
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
++ V L++ L + E+ K++ L E ++ E+++A+ E +KE + A
Sbjct: 339 DDLVVDLDNQRQLV-SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR--EKE-TKA 394
Query: 1498 LGEIKTLQEKLGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
L + L+E L + T K EM++ ++S ++ + E+E+++ A Q E
Sbjct: 395 LSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSK-RALETQMEE 452
Query: 1555 ELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXX 1614
+ D L+ D +ER + +
Sbjct: 453 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 512
Query: 1615 IEQSEKARKAEITDTKTRYEGQMNTMR----DELKSLHNQVSRFRR---ERDNYKQMLEA 1667
+ E+ ++A K + EG + + +K + + R+ + ++++ LE
Sbjct: 513 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 572
Query: 1668 AQKSMAEI----KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLAS 1723
A+ S EI K +K A+ + E+ + A +Q ++EL E LAS
Sbjct: 573 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA--RKQADLEKEELAEE--LAS 628
Query: 1724 KLN--TELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
L+ L EK E R+A+++ L E + S R R A
Sbjct: 629 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 671
>AJ238393-1|CAC20413.1| 1935|Homo sapiens beta-myosin heavy chain
protein.
Length = 1935
Score = 99.1 bits (236), Expect = 1e-19
Identities = 162/837 (19%), Positives = 342/837 (40%), Gaps = 71/837 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSD-LSRELEEISERLEEAGGATSCQIE 1162
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 1163 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQ +E+ S E ++++ + L+ +
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND---LTSQR 1277
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+EV +A LQ
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1337
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRTKYETDAIQRTEELEEAKKKLA 1394
Query: 551 D-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L+E E A C + + + D +V D+ S ++ K +
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 1452
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 1510
Query: 663 SLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL T K+ A K+ +++A + E + + ++ LE N+ +A
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ R+ E+ E+ ++A + ++ + S +TS + T +R K+
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETRSRNEALRVKKKM------- 1618
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 1619 -EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 840 IEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ ++L+A+ + L A E+ + E + ++ + + L S +N KK +++
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK--KMD 1731
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + +++E C++ + + K T+A + LK +Q
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1790
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K + +L+ +E + E M+ +
Sbjct: 1791 KDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEAEQKRNAESVKGMRKSERRI 1847
Query: 1015 KEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE+T +T +L+ +D+++ K+ + + + T ++K + V +L+
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Score = 82.6 bits (195), Expect = 1e-14
Identities = 190/1032 (18%), Positives = 396/1032 (38%), Gaps = 71/1032 (6%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +A K + +L+ S+ + +L+ ++ + QE + L+ + Q+ E DN E
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-EQDN-LADAEE 903
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE-KKVRFTE 924
+ QL+KN L + K ++N + + E E AK ++LE C + K + + T
Sbjct: 904 RCDQLIKNKIQLEA-KVKEMNERLEDEEEMNA-ELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 925 A-TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
A +KE ++K + L+ A + K T
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
K++L++ V+DLE + + V + + +++ KL +E I +ND + +
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE--SIMDL--ENDKQQLD 1077
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
E RL+ + +L +NA++E ++ + + K L+ + + + L E R A++ K
Sbjct: 1078 E--RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR-AKVEK 1134
Query: 1104 LSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKLLK 1161
L +DL + + + + ++ T + + L K
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
+ D ++G+ ++ + + D VT + T
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
E S+ +E Q S+ L+ E +L + K + K + +QLED
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
RQ +E + + +E AK +L++ S A E
Sbjct: 1315 LKRQLE----EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSE 1367
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+AQ ++ K E + +A+E + ++ L++ + +
Sbjct: 1368 VAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+++ ++ L++ K + E KQ+YEE+ +LE S ++ EL
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 1462 YELLEE--EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
EE EH+ T R E + Q E+ + ++L ++ I L EK+ + A EK
Sbjct: 1485 KNAYEESLEHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQLEA---EK 1537
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDVLEHHH----DXX 1573
E+Q+++ + L ++ RA+L N + ER+L ++ + + +H D
Sbjct: 1538 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 1597
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTR- 1632
+ RV K ++ K+ ++ + DT+ +
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Query: 1633 ----------------YEGQMNTMRDELKSLHNQVSRFRRERDNYKQ-MLEAAQKSMAEI 1675
E + N ++ EL+ L V + R R +Q ++E +++ ++
Sbjct: 1658 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER--VQL 1715
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE----LCESRLLASKLNTE--- 1728
+ ++ I++ D + + +V Q+ E++ + ++ ++A +L E
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1775
Query: 1729 ---LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
L K + E + ++Q RL+E E+ L G+ ++ L R+ ++ EQ+R
Sbjct: 1776 SAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834
Query: 1786 QETSTLARDLRQ 1797
+ + + R+
Sbjct: 1835 ESVKGMRKSERR 1846
Score = 75.8 bits (178), Expect = 1e-12
Identities = 191/1082 (17%), Positives = 411/1082 (37%), Gaps = 82/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 859 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 914
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + + L ++L T A+VE++
Sbjct: 915 --LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----RDIDDLELTLAKVEKEK 968
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 1019
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + +ER
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 1139
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 1140 SRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 1260 RSKAEETQRSVND--LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 1316
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 1317 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1374
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 1128 XXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K + +L SER + L + K DA+L
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1852
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1853 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1912
Query: 1566 LE 1567
E
Sbjct: 1913 AE 1914
Score = 70.1 bits (164), Expect = 7e-11
Identities = 236/1189 (19%), Positives = 463/1189 (38%), Gaps = 146/1189 (12%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + +L+ L +E +EL ++ + +E DL
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 406 QDNFR--EDQADEYSSLRRELEQTIK--NCRV---------LSFKLKKTERKADQLEQEK 452
QDN E++ D+ + +LE +K N R+ L+ K +K E + +L+++
Sbjct: 895 QDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDI 954
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E+ +L +E + L
Sbjct: 955 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-- 1010
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E +R L A+ + ++
Sbjct: 1011 --QAEEDKVN--TLTKAKVKLE--QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ +D + ++ + + ++ K + + E + + K +E Q
Sbjct: 1065 SIMDLE-----------NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
+ + + A R A+VE+ L +L+++ S +L A IE
Sbjct: 1114 RIE----ELEEELEAE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSCQIE 1162
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSK 748
N E E + + L+ +E A LR+K V EL + + L++ VK+ K
Sbjct: 1163 M-NKKREAEFQKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEK 1219
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS 808
S K T+ + L E+ + LED+++E R K E +R +L+
Sbjct: 1220 EKSEFKLELDDVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVN----DLT 1274
Query: 809 LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL-RAK---TQSLEADNEKLQTE 864
+ K +T +N +L RQL E S L R K TQ LE +L+ E
Sbjct: 1275 SQRAKLQT------------ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 865 NKKLQLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
K L +A +S R D DL + Q E E EA A+++ + E ++ +
Sbjct: 1323 VKAKNALAHALQSARHD--CDLLRE---QYEEET-EAKAELQRVLSKANSEVAQWR---- 1372
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
TK ETD ++ + + L +A+++ + K +
Sbjct: 1373 --TKYETDAIQRTEELEEA---------------KKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
TK +L+ +EDL ++ NA + + + +K + E + K ++ SE +
Sbjct: 1416 KTKHRLQNEIEDLMVDVER-----SNAAAAALDKKQRN-FDKILAEWKQKYEESQSELES 1469
Query: 1044 ---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
E L TE+ KLK NA E + + EN NL + LTE++ +
Sbjct: 1470 SQKEARSLSTELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKT 1522
Query: 1101 INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLL 1160
I++L K + + + + Q+ K ++
Sbjct: 1523 IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---------KAEIE 1573
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
+++ +K +++ + ++ + +R + + + L++ +
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R++ E + LQ+ T+ I L+ +R D + I +E +++L
Sbjct: 1634 -RMAAEAQKQVKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEEL 1688
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+ QT + +E E R Q + +A + +TE E + +
Sbjct: 1689 RAVVEQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
A+ K+ K S++ E K ++ ++ + +LD A
Sbjct: 1748 CRNAEEKA--KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQ 1802
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
+K +L L+ +++ LE A KR E + ++K E +++ Y+
Sbjct: 1803 IALKGGKKQLQKLEARVRELENELEAEQKR----NAESVKGMRKSER--RIKELTYQTEE 1856
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ LL + +V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 1857 DRKNLLRLQDLVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 1903
Score = 70.1 bits (164), Expect = 7e-11
Identities = 175/879 (19%), Positives = 356/879 (40%), Gaps = 93/879 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRSSE 318
+++ D +EG ++ +R ER +++ + D+ L + + +D N + + E
Sbjct: 1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 1086
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ--------TRQIEQL 370
+ L ++ + L+ + K L +I E+E ELE + A+ +R++E++
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146
Query: 371 RAKLLAA--ETLCEELMD-----ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE 423
+L A T C+ M+ E + M+++L + R+ AD + E
Sbjct: 1147 SERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVA----E 1202
Query: 424 LEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVA 483
L + I N + + KL+K E+ +LE + + + +I+ +++ R E +
Sbjct: 1203 LGEQIDNLQRVKQKLEK-EKSEFKLELD--DVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 484 RS-TEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
RS E R +L +K N L + Q + + S LTRG + Q L DL
Sbjct: 1260 RSKAEETQRSVNDLTSQRAKLQTENGELSR--QLDEKEALISQLTRG--KLTYTQQLEDL 1315
Query: 543 QDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS--IQ 600
+ LE E + L +A + + L +Q + ++ + NS Q
Sbjct: 1316 KRQLEEEVKAKNALAHALQSAR-----HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1370
Query: 601 NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED 660
+ + E+ + + + +E + + + ++L KT R++ +
Sbjct: 1371 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV------NAKCSSLEKTKHRLQNE 1424
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQ 719
E L++ +++ + A + +K+ E +E +++ E+ E + L
Sbjct: 1425 IEDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----ST 1479
Query: 720 EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERV 779
E L+ EE + E K++ K L +IS +T+ GS+ L +L E++
Sbjct: 1480 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKM 1538
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QLQ 838
+ L+ ++E L +E + L A+L Q K + R L D++ KR L+
Sbjct: 1539 E-LQSALEEAEASLEHEEG--KILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLR 1592
Query: 839 VIEQEASVLRAKTQS----------LEAD-NE---KLQTENK-KLQLLKNAKSLRS-DKA 882
V++ + L A+T+S +E D NE +L N+ + K KSL+S K
Sbjct: 1593 VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 883 LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK--VRFTEATKK--ETDTLKSKQX 938
+ + ++LKE +A ++ + Q E E + V TE ++K E + +++ +
Sbjct: 1653 TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE- 1711
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC 998
A L L+ + +++ + + + KK + D
Sbjct: 1712 RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-------ECRNAEEKAKKAITDAAM 1764
Query: 999 EIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKD 1057
E+ K S K +E+ I +++ +L + + K +LQ A++++
Sbjct: 1765 MAEEL---KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1821
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+ +LE ++ A K + + E+ KN
Sbjct: 1822 LENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1860
Score = 64.1 bits (149), Expect = 5e-09
Identities = 150/865 (17%), Positives = 348/865 (40%), Gaps = 68/865 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ +D+ LK+++D L +VEKEK T NK + E+ L + +
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKH----------ATENK-VKNLTEEMAGLDEII 989
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAETLCEELM 385
+LT + L++ + ++ E ++ T + + +Q++ L L E+
Sbjct: 990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSL-------EQEK 1042
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
D+++ R L Q++ + + D+ L L++ L+ +++ +
Sbjct: 1043 KVRMDLERAKRKLEGDLKLTQESIMDLENDK-QQLDERLKKKDFELNALNARIEDEQALG 1101
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQREN-RIKELEQEVARSTEVALRLQRELAEANSKFT 504
QL+++ E + ++ E+ + + ++++L +++R E + L EA T
Sbjct: 1102 SQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELE---EISERLEEAGGA-T 1157
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETA 564
+ K + E K+ R E A LR + + A+L EQ+ N +
Sbjct: 1158 SCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR--KKHADSVAELGEQIDNLQRVKQ 1215
Query: 565 NCKQVNPPTFLDKQVMTDNI--VTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
++ L+ +T N+ + E + +++++M S ++S + L+
Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN-DLT 1274
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ +T+ + +L + L + + E L QL++ KA++ L+
Sbjct: 1275 SQRAKLQTE-NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEE-EVKAKN-ALAH 1331
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA-------TVLRRKVEELEQDK 735
+ + + + E+ET EA ++L + N + A T ++ EELE+ K
Sbjct: 1332 ALQSARHDCDLLREQYEEET-EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVKVLEDEIDEVR---- 790
+ L ++++E + +V + T R + + + ER +D+ +
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1450
Query: 791 KKLIEKERDCERLHAELSLAQKKPKT----LIKSRSLDASDQQNVD-LKRQLQVIEQEAS 845
K L E ++ E +EL +QK+ ++ L K ++ ++++ KR+ + +++E S
Sbjct: 1451 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1510
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
L T+ L + + + E +K++ A+ + AL+ E ++ A +
Sbjct: 1511 DL---TEQLGSSGKTIH-ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
+++ + + +EK +A + + S Q + L +
Sbjct: 1567 QIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM- 1625
Query: 966 DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK--- 1022
+ Q S R+ + LQ +++D + ++ + V N L + +
Sbjct: 1626 -EIQLSHANRMAAEAQKQVKSLQ--SLLKDTQIQLDD--AVRANDDLKENIAIVERRNNL 1680
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
L+ E++E+R+ + + + + + E+ + + L N+ K ++ + S
Sbjct: 1681 LQAELEELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQ 1736
Query: 1083 LSNQCKTLTEEMKNREAQINKLSAD 1107
L + + +E +N E + K D
Sbjct: 1737 LQTEVEEAVQECRNAEEKAKKAITD 1761
>AC012487-1|AAX88838.1| 1583|Homo sapiens unknown protein.
Length = 1583
Score = 99.1 bits (236), Expect = 1e-19
Identities = 261/1316 (19%), Positives = 528/1316 (40%), Gaps = 127/1316 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++++ KE++ +I L + + L K+CE EK +I + ++ K T+ + +
Sbjct: 158 IEASAKEHEAEINKLNELKENLVKQCEASEK---NIQKKYECELENLRKATSNANQDNQI 214
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETL 380
+ E T + + ++ KHL ++E+ES+ + + + L+ KL + A+ +
Sbjct: 215 CSILLQENTFVEQVVNEKVKHLEDTLKELESQ---HSILKDEVTYMNNLKLKLEMDAQHI 271
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK--NCRVLSFKL 438
+E E ED++ ++ +L Q E E + L ++ T++ N V S K
Sbjct: 272 KDEFFHEREDLEFKINELLLAKEE-QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE 330
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGM--QRENRIKELEQEVAR---STEVALRLQ 493
+ + ++ E ++ EK+ L ++ G+ Q EN +E ++ + E+ LQ
Sbjct: 331 QHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQ 390
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP-AQLLRDLQDSLEREADL 552
EL E+ K + S MK Q V + L +++D + + LQ E+
Sbjct: 391 TELGESAGKISQEFES-MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ 449
Query: 553 REQLRNAEEETANCKQVNPPTFL---DKQVMTDNI---VTCDIHESETVTNSIQNKMIHA 606
+E + E N ++ N L + M + + E + N ++N
Sbjct: 450 QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEM 509
Query: 607 ASTPSSKEKSDSPPLSIDKTTEET-QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
+ E+ + L + K E+T Q++ +L N + L +T +++++
Sbjct: 510 DNFHKKCEREERLILELGKKVEQTIQYNSELE--QKVNEL-TGGLEETLKEKDQNDQ--- 563
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
+L+K+ + + LS +++ + + K + E L + L+++E +L+
Sbjct: 564 -KLEKL--MVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 620
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
+ +LE+ + + ++ L + + T L ++++E+ E +
Sbjct: 621 EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSE---EKD 677
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV----DLKRQLQVIE 841
+ V + + E L+ Q+ K L + + +++V +LK L+ E
Sbjct: 678 VVNVLQAVGESLAKINEEKCNLAF-QRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE 736
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
QE +LR + + ++++ E LQ++ L +KNA N K T+LEN+ L
Sbjct: 737 QEKVLLRKELEEIQSEKEALQSD---LLEMKNA-----------NEK--TRLENQ--NLL 778
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
+++E+ C KSE + KE + LK +A L
Sbjct: 779 IQVEEVSQTC--SKSEIHNEKEKCFIKEHENLKP------------LLEQKELRDRRAEL 824
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKT 1021
LKD KS P + P L++ +L++ +E+LE E E K ++ ++ A
Sbjct: 825 ILLKDSLAKS--PSVKNDP--LSSVKELEEKIENLEKECKE-----KEEKINKIKLVA-V 874
Query: 1022 KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENS 1081
K +KE+D R + E + ++ A ++D+ ++G A YK L E
Sbjct: 875 KAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDL---IQG-----AESYKNLLLEYE 926
Query: 1082 NLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
S Q E N E +I L+ L+N+T T++
Sbjct: 927 KQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEV 986
Query: 1142 XXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXX 1201
+V K DK +L E K +KI + +++KQ ++ + T
Sbjct: 987 QILEVQR-AKAMVDK-ELEAEKLQKEQKIKEHATTVNELEELQVQLQKQ--KKQLQKTMQ 1042
Query: 1202 XXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYE-- 1259
Q L N + EL + +K LE E++ K E
Sbjct: 1043 ELELVKKDAQQTTLMNME---IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETL 1099
Query: 1260 -NKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
+ITSL+S++ + +++ L +T + D + + + ++
Sbjct: 1100 QEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQV 1159
Query: 1319 D--ELNNAKIKLEK---TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYW 1373
+ ++ A+I EK E ++A+ L + ++ +S +
Sbjct: 1160 EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF 1219
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAK-RITE 1432
E+ + L+ ++ K M A + K + L L +LKI Q+S + ++E
Sbjct: 1220 ESYKVRVHNVLKQQKNK--SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSE 1277
Query: 1433 LK--QEYEETV-----KKLEHSLALEKAEYEEL---TGKYELLEEEHVVTKARLTVEKE- 1481
L+ Q +T+ K L+ +++ E E+L + +++ EH T ++LT + E
Sbjct: 1278 LQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEV 1337
Query: 1482 ---QAQGELLHVQKELSTALGEIKTLQEKLG-TESAAWNTEKTEMQNSIASLQERL 1533
+ ++ H+Q+E ++TLQ++L E+ + + S S Q+ L
Sbjct: 1338 LRNSFRDQVRHLQEEHRKT---VETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSL 1390
Score = 72.9 bits (171), Expect = 1e-11
Identities = 232/1298 (17%), Positives = 481/1298 (37%), Gaps = 88/1298 (6%)
Query: 263 DSNVKEYQDQIE----GLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSE 318
+ NVK+ Q++IE G ++++ L+K+ + EK + + + L NI AN ++
Sbjct: 76 EDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQ-LQNIIEANSQHYQKN-- 132
Query: 319 VLKLQQKVNELTT-HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
+ LQ+++ +L H E++++ + +E E+E+ E + ++Q A
Sbjct: 133 INSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKL--NELKENLVKQCEASEKNI 190
Query: 378 ETLCE-ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
+ E EL + + +D +Q+N +Q + + LE T+K
Sbjct: 191 QKKYECELENLRKATSNANQDNQICSILLQENTFVEQV--VNEKVKHLEDTLKELESQHS 248
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
LK + L+ K E + + ++ + E +I EL V +L+ EL
Sbjct: 249 ILKDEVTYMNNLKL-KLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSEL 307
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
A N +F + + Q SL +E L DS + + L ++
Sbjct: 308 AGLNKQFCYTVEQHNREVQ---------SLKEQHQKEISELNETFLSDSEKEKLTLMFEI 358
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTD--NIVTCDIHESE-TVTNSIQN-KMIHAASTPSS 612
+ +E+ N +Q L+ + + + I+ ++ ES ++ ++ K A+
Sbjct: 359 QGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHEL 418
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
++K + D E + L T ++E N LL L +
Sbjct: 419 QQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRD 478
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE 732
T + + N L+ E + ++ + + E E+ L +KVE+
Sbjct: 479 TMLKELE----GKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI 534
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
Q L+++V ELT + K N L L+E++ +VL E+ K
Sbjct: 535 QYNSELEQKVNELTGGLEETLKEK-DQNDQKLEKLMVQMKVLSEDK-EVLSAEV----KS 588
Query: 793 LIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
L E+ L+ +K K L + + S +++V LK + +E++ ++ +
Sbjct: 589 LYEENN---------KLSSEK-KQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQD 638
Query: 853 SLEA--DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
+L +NE++Q K QL K + S+ + D K + + E+LAKI E +
Sbjct: 639 NLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCN 698
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
++ EK + +KE +K Q + L+ ++ Q
Sbjct: 699 LAFQRDEKVLEL----EKE---IKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQ- 750
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEI 1030
S K + +DL L++K E E + + ++ + +K+++ E ++
Sbjct: 751 SEKEALQ---SDL---LEMKNANEKTRLENQNLLIQVEEVS----QTCSKSEIHNEKEKC 800
Query: 1031 RSKLSKNDSEFTNEKNRL--QTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
K +N +K + E+ LKD AK K+ + K LE + NL +CK
Sbjct: 801 FIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECK 860
Query: 1089 TLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN 1148
E++ + K +L ++ T+ + + N
Sbjct: 861 EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 920
Query: 1149 ----YTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
Y K + + + + +I D C+ I R+
Sbjct: 921 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSN 980
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDELQARF---IKTESKFITLEAEMRDLKADYENK 1261
Q + + + EL +EK + + + T ++ L+ +++ K +
Sbjct: 981 AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQLQKT 1040
Query: 1262 ITSLESTIA-AKDVHIKQLE----DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ LE A+ + +E + L + N K + +E +E
Sbjct: 1041 MQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE--IKIQKQKQET 1098
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENK 1376
Q+E+ + + +++ E +++ K + + K +LA + + +
Sbjct: 1099 LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQ 1158
Query: 1377 AKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQE 1436
+ L + ++ + L+ + ++ L++ A + E
Sbjct: 1159 VEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSE 1218
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELST 1496
+ E+ K H++ ++ + E ++E + L + +Q + +L Q L
Sbjct: 1219 F-ESYKVRVHNVLKQQKNKSMSQAETEGAKQE----REHLEMLIDQLKIKLQDSQNNLQI 1273
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLC 1534
+ E++TLQ + T N E + A L+E+LC
Sbjct: 1274 NVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLC 1311
Score = 66.1 bits (154), Expect = 1e-09
Identities = 226/1225 (18%), Positives = 476/1225 (38%), Gaps = 113/1225 (9%)
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+EL + + KE+ +L ++ + ED+A +L+++LE+ + LS +LK
Sbjct: 17 KELEQSHINYVKEIENLKNELMAVRSKYSEDKA----NLQKQLEEAMNTQLELSEQLKFQ 72
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
D +++ + E EK I G + Q K+L+ E +LQ + EANS
Sbjct: 73 NNSEDNVKKLQEEIEK----IRPGFE-EQILYLQKQLDATTDEKKETVTQLQ-NIIEANS 126
Query: 502 KFTGSN-PSL------MKVPQPETVKVSRSSLTRGGSQEDPAQL--LRDLQDSLEREADL 552
+ N SL +K E VK + ++E A++ L +L+++L ++ +
Sbjct: 127 QHYQKNINSLQEELLQLKAIHQEEVKELMCQI-EASAKEHEAEINKLNELKENLVKQCEA 185
Query: 553 RE---------QLRNAEEETANCKQVNP--PTFLDKQVMTDNIVTCDI-HESETV----- 595
E +L N + T+N Q N L + + +V + H +T+
Sbjct: 186 SEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELES 245
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
+SI + + K + D+ + + E F + L + + K +
Sbjct: 246 QHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKS 305
Query: 656 RVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDND-EKETDEADPAEMKLLL 714
+ N+ +++ + +S K ++L+ +D++ EK T + +K
Sbjct: 306 ELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQC 365
Query: 715 ELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
E +QE E L + E L+ ++ E KIS ++ + L
Sbjct: 366 ENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTA 425
Query: 775 AEERVKVLE--DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E+ +LE + + +KL+ ++ L + Q+K + S S + + ++
Sbjct: 426 FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE 485
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
K E++ + + K E DN + E ++ +L+ K + ++ + N+ + Q
Sbjct: 486 GKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKV--EQTIQYNS-ELEQ 542
Query: 893 LENELKEALAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXX 951
NEL L + +KE + D+K EK + + ++ + L ++
Sbjct: 543 KVNELTGGLEETLKEKDQ--NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEK 600
Query: 952 XXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAG 1011
S K+D K I T L KLQL MVE+ + + +++N
Sbjct: 601 KQLSRDLEVFLSQKEDV--ILKEHI----TQLEKKLQL--MVEEQD----NLNKLLENEQ 648
Query: 1012 LSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT---EIAKLKDVNAKLEGDKD- 1067
+ +++ KT+L + E+ S++S+ DSE + N LQ +AK+ + L +D
Sbjct: 649 V--QKLFVKTQLYGFLKEMGSEVSE-DSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDE 705
Query: 1068 ---VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN-ATSLQTTMSDCMX 1123
+ K L+ E+ + K+L + + + + K ++++ +LQ+ + + M
Sbjct: 706 KVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLE-MK 764
Query: 1124 XXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI---GDXXXXXXXX 1180
Q + ++I +K K + + K + +
Sbjct: 765 NANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAEL 824
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-IELTSEKDELQARFIK 1239
+ K S + D ++ +++ I+L + K + + +
Sbjct: 825 ILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSR 884
Query: 1240 TESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVE 1299
E++ T++ E+ L+++ + S+ I + + L + +Q +++ D
Sbjct: 885 KETQ--TVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQ--SEQLDVEKERAN 940
Query: 1300 MVEMRXXXXXXXXXXXXXQDELNNAK-----IKLEKTEAESSAAKLEMAQLKSDLAKLEN 1354
E R Q E N+ ++E ++ + ++++ +++ A ++
Sbjct: 941 NFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDK 1000
Query: 1355 XXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKG 1414
+ N+ +EL LQ ++K+L + + ++ KDA+ TL
Sbjct: 1001 ELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQL--QKTMQELELVKKDAQQTTLMN 1058
Query: 1415 K--------LKILEQNSGAGAKRITELKQEY------EETVKKLEHSLALEKAEYEELTG 1460
+K L Q +I +L+QE +ET+++ SL +YEE
Sbjct: 1059 MEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNT 1118
Query: 1461 KYELL--------------EEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQE 1506
K + L E +H++ +A L E E +Q ++ + +L+ E + E
Sbjct: 1119 KIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHE 1178
Query: 1507 KLGTESAAWNTEKTEMQNSIASLQE 1531
L T + + Q + +LQE
Sbjct: 1179 HLKTSAEQHQRTLSAYQQRVTALQE 1203
Score = 55.6 bits (128), Expect = 2e-06
Identities = 120/679 (17%), Positives = 287/679 (42%), Gaps = 48/679 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
+E + + +QE +LRK E ++ EK + L L + AN+ T + +L ++V
Sbjct: 726 EELKSLLRDYEQEKVLLRKELEEIQSEK-EALQSDLLEMKNANEKTRLENQNLLIQVEEV 784
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL------ 380
++ + +E +++K ++ ++ LE + + + I L+ L + ++
Sbjct: 785 SQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELI-LLKDSLAKSPSVKNDPLS 843
Query: 381 -CEELMDENEDMKKELRDLXXXXXXMQ------DNFREDQADEYSSLRRELEQTIKNCRV 433
+EL ++ E+++KE ++ ++ + E +++ ELE
Sbjct: 844 SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQ 903
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEI-VGGPDGMQRENRIKELEQEVARSTEVALRL 492
LS ++ + A+ + E+EK+ ++ V E+RI++L +++ ST +
Sbjct: 904 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 963
Query: 493 QRELAE--ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE--DPAQLLRDLQDSLER 548
+ + A + SN L++V E V+ +++ + + E Q +++ ++
Sbjct: 964 NSDNEDLLARIETLQSNAKLLEVQILE-VQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1022
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
+L+ QL+ +++ K + + K ++ +I + E + + K+ + +
Sbjct: 1023 LEELQVQLQKQKKQLQ--KTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNN 1080
Query: 609 TPSSKEKSDSPPLSIDKTTEE--TQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
E+ +T +E T + N L KT + + ++
Sbjct: 1081 KIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETD 1140
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
L A+ + S I+ A EK +K E +++ + ++
Sbjct: 1141 HLILQASLKGELEASQQQ-VEVYKIQLAEITSEKHKIHE---HLKTSAEQHQRTLSAYQQ 1196
Query: 727 KVEELEQDKEALKKQVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
+V L+++ A K + +TS+ S + +S++ + A++ + LE
Sbjct: 1197 RVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEML 1256
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK--SRSLDASDQQNVDLKRQLQVIEQE 843
ID+++ KL + + + + +EL Q + TL++ ++ L + + +L+ +L I+ E
Sbjct: 1257 IDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSE 1316
Query: 844 ASVLRAK-TQS---LEADNE-----------KLQTENKK-LQLLKNAKSLRSDKALDLNT 887
+++++ TQ+ L + NE LQ E++K ++ L+ S + L
Sbjct: 1317 NMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKN 1376
Query: 888 KKTTQLENELKEALAKIKE 906
+ TT+ +++L ++E
Sbjct: 1377 EPTTRSPVSSQQSLKNLRE 1395
Score = 50.0 bits (114), Expect = 8e-05
Identities = 194/1088 (17%), Positives = 416/1088 (38%), Gaps = 87/1088 (7%)
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
+++E L+ + A++ + E + + + + + L +N +E+ VK L++E
Sbjct: 28 KEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNN--SEDNVKKLQEE 85
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ---QNVDLKR----QLQ 838
I+++R E+ ++ + + +KK ++A+ Q +N++ + QL+
Sbjct: 86 IEKIRPGFEEQILYLQK-QLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLK 144
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE-L 897
I QE ++ +EA ++ + E KL LK ++ +A + N +K + E E L
Sbjct: 145 AIHQEE--VKELMCQIEASAKEHEAEINKLNELKE-NLVKQCEASEKNIQKKYECELENL 201
Query: 898 KEALAKIKELEMICQ---DEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
++A + + IC E + + E K DTLK +
Sbjct: 202 RKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLK 261
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ + +KD+ F R DL K+ +L E+ C I ++ + AGL+
Sbjct: 262 LKLEMDAQHIKDEF---FHER-----EDLEFKINELLLAKEEQGCVIEKLKSEL--AGLN 311
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ + +E+ ++ + K SE NE +E KL + +++G K+ N
Sbjct: 312 KQFCYTVEQHNREVQSLKEQHQKEISEL-NETFLSDSEKEKLT-LMFEIQGLKEQCEN-- 367
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA-TSLQTTMSDCMXXXXXXXXXX 1132
L+ E ++L E M+ + ++ + + + S++ + +
Sbjct: 368 --LQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTA 425
Query: 1133 XXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLS 1192
++ + + +L+ E+ + K + + + K+L
Sbjct: 426 FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE 485
Query: 1193 TRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMR 1252
+ + +T L N+H + + +K E + R I K + +
Sbjct: 486 GKINSLTEEKDDFINK------LKNSHEEM--DNFHKKCEREERLILELGKKVEQTIQYN 537
Query: 1253 DLKADYENKITS-LESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXX 1311
N++T LE T+ KD + ++LE + Q D+ E+ +
Sbjct: 538 SELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL-------- 589
Query: 1312 XXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSS 1371
++L++ K +L + + E ++ E LK + +LE
Sbjct: 590 ---YEENNKLSSEKKQLSR-DLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 645
Query: 1372 YWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKL-KILEQNSGAGAKRI 1430
+ + + T L K++ ++ D + K+ L + L KI E+ +R
Sbjct: 646 NEQVQKLFVKTQLYGFLKEMGS-EVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQR- 703
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKA--RLTVEKEQAQGELL 1488
E E E+ +K L+ ++ E + L YE +E+ ++ K + EKE Q +LL
Sbjct: 704 DEKVLELEKEIKCLQEESVVQCEELKSLLRDYE--QEKVLLRKELEEIQSEKEALQSDLL 761
Query: 1489 HVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR 1548
++ E + L + E + K+E+ N ++ C + E L
Sbjct: 762 EMKNANEKTRLENQNLL--IQVEEVSQTCSKSEIHN-----EKEKC---FIKEHENLKPL 811
Query: 1549 LDQRERELRAAND--RRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXX 1606
L+Q+E R A +D L E + K +
Sbjct: 812 LEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL 871
Query: 1607 XXXXXXXXIEQSEKAR---KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQ 1663
++ S K K E+ ++ + +MRD ++ + + +Q
Sbjct: 872 VAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQ 931
Query: 1664 M-LEAAQKSMAEIKNGDKSARIHRNSIS----STDEEEYRNKVALLEQQVACLEDELCES 1718
+ +E + + E + D + ++ +++ ++D E+ ++ L+ LE ++ E
Sbjct: 932 LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 991
Query: 1719 RLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERL-LSSGRARVAGLATRMELAWHKE 1777
+ + ++ EL +EK E ++ E + +NE EE ++ L + ++ +EL +
Sbjct: 992 QRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQLQKTMQELELV---K 1048
Query: 1778 RDEQQRLL 1785
+D QQ L
Sbjct: 1049 KDAQQTTL 1056
Score = 38.3 bits (85), Expect = 0.28
Identities = 58/342 (16%), Positives = 133/342 (38%), Gaps = 23/342 (6%)
Query: 162 NDSLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKE--DEKTARYKDERSSTKDDV 219
N L + K++ L+ + +K+ + E SL S + +EK + K TK ++
Sbjct: 1072 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKEL 1131
Query: 220 NFLMQVKNSRN--STNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVK----EYQDQI 273
Q + +LK + + ++K ++Q +
Sbjct: 1132 ADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1191
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
+Q V L++ C + E++ + Y R VLK Q+ +
Sbjct: 1192 SAYQQRVTALQEECRAAKAEQATVT-------SEFESYKV-RVHNVLKQQKNKSMSQAET 1243
Query: 334 EDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMK 392
E + E++HL I +++ +L +++ + + +++ L+++ +++ E +
Sbjct: 1244 EGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKE 1303
Query: 393 KELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK-ADQLEQE 451
ELR+ + + S L + E + R L++ RK + L+Q+
Sbjct: 1304 AELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQ 1363
Query: 452 KAEHEKKLLEIVGGP---DGMQRENRIKELEQEVARSTEVAL 490
++ E +L ++ P + + +K L + R+T++ L
Sbjct: 1364 LSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRER--RNTDLPL 1403
>AB209996-1|BAE06078.1| 2585|Homo sapiens CENPE variant protein
protein.
Length = 2585
Score = 99.1 bits (236), Expect = 1e-19
Identities = 282/1543 (18%), Positives = 616/1543 (39%), Gaps = 132/1543 (8%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
SE+ L+ + L E LR EK+ + K++E +++L+ + E +T++ ++ L+
Sbjct: 503 SELNSLRADYDNLVLDYEQLRTEKEEMELKLKE-KNDLDEFEALERKTKKDQENE---LS 558
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR--RELEQTIKNCRVL 434
++ EL+ E ED K+L++ +N + D + S+ ++++QT+ + +
Sbjct: 559 SKV---ELLREKEDQIKKLQEYIDSQKL--ENIKMDLSYSLESIEDPKQMKQTLFDAETV 613
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+ K R++ L E E ++K+ E+ Q EN I+ + ++ ++ + L++
Sbjct: 614 ALDAK---RESAFLRSENLELKEKMKELA--TTYKQMENDIQLYQSQLEAKKKMQVDLEK 668
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS--LEREADL 552
EL A ++ T SL+ P+ + + G + +L ++++++ L E L
Sbjct: 669 ELQSAFNEITKLT-SLIDGKVPKDLLCNLE--LEGKITDLQKELNKEVEENEALREEVIL 725
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMT---DNIVTCDIHESETVTNSIQN--KMIHAA 607
+L++ E ++ + ++T D + + +H+ V ++ K
Sbjct: 726 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 785
Query: 608 STPSSKEKSDSPPLSIDKTTE---ETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESL 664
+T S KS KT E ++ L N N L K A + + +L
Sbjct: 786 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN-LSKEAQKFDSSLGAL 844
Query: 665 LLQL--KKMATKARSRKLSPT-PPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
+L K + ++R++ +L + N + +T E + + L+ +E
Sbjct: 845 KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 904
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
L ++ ++L+Q +E+L+ + +L S I + + R +L S K +E +
Sbjct: 905 KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNAL--ESLKQHQETINT 962
Query: 782 LEDEI-DEVRKKLIEKERDCE---RLHAELSLAQKKPKTLIKSR---SLDASDQQNVDLK 834
L+ +I +EV + L +E E ++ KK K+ + D D + ++ +
Sbjct: 963 LKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQ 1022
Query: 835 RQLQVIEQEASVLRAKTQSLEADNEKLQTENKK-LQL-LKNAKSLRSDKALDLNTKKTTQ 892
R++ + QE + L+ +S+ A+ E+L+T+ K+ +++ ++N + LR L KK +
Sbjct: 1023 RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELR---LLGDELKKQQE 1079
Query: 893 L-ENELKEALAKIKELEMICQ-----DEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
+ E A+ K EL C +EK ++K + + +++ ++ +
Sbjct: 1080 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1139
Query: 947 XXXXXXXXXXXQATLKSLKDD----AQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGE 1002
+ TL+ ++ + AQK + K K+ LK++ + E E
Sbjct: 1140 IENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV-LKELQKSFETERDH 1198
Query: 1003 MYVVMKNAGLSGKEMTAKTKL--------EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
+ ++ +G + + K+ ++ IDE+R +S+ ++ N ++ L+ K
Sbjct: 1199 LRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD-LEKSHTK 1257
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA------QINKLSADL 1108
L++ L ++++ N + E + + N+ + LTE+ +++ ++ +L +
Sbjct: 1258 LQEEIPVLHEEQELLPNVKEVSETQET--MNELELLTEQSTTKDSTTLARIEMERLRLNE 1315
Query: 1109 KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKL-----LKEV 1163
K S + S + KI + ++K +KE
Sbjct: 1316 KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1375
Query: 1164 GDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS 1223
++T KI RIE ++ R+ + L +RL
Sbjct: 1376 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL----QRLQ 1431
Query: 1224 IELTSEKDELQARFIKTESKFITLEAEMRDLKA---DYENKITSLESTIAAKDVHIKQLE 1280
L SE D+L+ + +K + E E++ + E I L ++ K+ I ++
Sbjct: 1432 EVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQ 1491
Query: 1281 DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL 1340
L + NDK + E + Q+++N K E +A+ SA
Sbjct: 1492 KQL-EAINDKLQNKIQEIYEKEEQFNIKQISEV----QEKVNELKQFKEHRKAKDSA--- 1543
Query: 1341 EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK 1400
+ ++S + +L N + + L + + + K+ + +A K
Sbjct: 1544 -LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIE-RDQLKENTKEIVAKMK 1601
Query: 1401 DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTG 1460
+ + K+ + + + E+ I LK+++E LE+ + E ++
Sbjct: 1602 ESQEKEYQFLKMTAVNETQEKMC-----EIEHLKEQFETQKLNLEN-IETENIRLTQIL- 1654
Query: 1461 KYELLEEEHVVTKARLTVEKEQAQGELLHVQKE-LSTALGEIKTLQEKLGTESAAWNTEK 1519
+E LEE VTK R + + E L V+++ L L E T + E +
Sbjct: 1655 -HENLEEMRSVTKERDDLRSVE---ETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1710
Query: 1520 TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXX 1579
E Q +I L+ G E+ + +++L +ND +
Sbjct: 1711 KEHQETIDKLR------GIVSEKTN---EISNMQKDLEHSNDALKAQDLK--IQEELRIA 1759
Query: 1580 XXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNT 1639
E + K++ +E S + +I + K E Q+ T
Sbjct: 1760 HMHLKEQQETIDKLR----GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN-EHQLIT 1814
Query: 1640 MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRN 1699
++ ++ +VS + + K ++ S EI+N + + ++H N + R+
Sbjct: 1815 LKKDVNETQKKVSEMEQLKKQIKD--QSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD 1872
Query: 1700 KVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSG 1759
+ +E+ + D+L ES + E+ E +A + E + +++ E+ +S
Sbjct: 1873 NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREK--ISEK 1930
Query: 1760 RARVAGLATRMELA---WHKERDEQQRLLQETSTLARDLRQTL 1799
+++ + ++ + K++D Q ++ L D +Q L
Sbjct: 1931 TIQISDIQKDLDKSKDELQKKQDRQNHQVKPEKRLLSDGQQHL 1973
Score = 94.3 bits (224), Expect = 4e-18
Identities = 194/1092 (17%), Positives = 405/1092 (37%), Gaps = 52/1092 (4%)
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKL--LLELNEQEATVLRRKVEELEQDKEALKK 740
T +KLSI + DE E+D L L E+ AT L + E +E + +L+
Sbjct: 452 TTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQ-ENIESELNSLRA 510
Query: 741 QVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV-LEDEIDEVRKKLIEKERD 799
L + + + + E + K E+E+ + L EKE
Sbjct: 511 DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQENELSSKVELLREKEDQ 570
Query: 800 CERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE 859
++L + + + + S SL++ + +K+ L + E L AK +S +E
Sbjct: 571 IKKLQEYIDSQKLENIKMDLSYSLESIEDPK-QMKQTL--FDAETVALDAKRESAFLRSE 627
Query: 860 KLQTENKKLQLLKNAKSLRSDKAL---DLNTKKTTQ--LENELKEALAKIKELEMICQDE 914
L+ + K +L K + +D L L KK Q LE EL+ A +I +L + +
Sbjct: 628 NLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGK 687
Query: 915 KSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKP 974
+ + E K TD K + LKSL + ++ +
Sbjct: 688 VPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL-----SELKSLPSEVER-LRK 741
Query: 975 RIPKKPTDLTTKLQLK-KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSK 1033
I K +L K K+ ++ + + +++ G + ++ K D+
Sbjct: 742 EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQN 801
Query: 1034 LSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEE 1093
+F + + E ++ L + F + AL+ E S + + + T E
Sbjct: 802 FKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTRE 861
Query: 1094 MKNREAQINKLSADLKNATS-LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKI 1152
++ R ++ +L L+N S LQT + +
Sbjct: 862 VQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESL 921
Query: 1153 DQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQA 1212
++++L ++ D D K+ ++ ++T K +++
Sbjct: 922 QIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENT 981
Query: 1213 VVLANTHRRLSIELTSEKDELQARFIKT------ESKFITLEAEMRDLKADYENKITSLE 1266
+ ++ + + +K +L+A+ +T +++ I + ++ L + LE
Sbjct: 982 GETKDEFQQKMVGI-DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLE 1040
Query: 1267 STIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKI 1326
S IA K+ L++ + T ++ + E+ + + + EL+
Sbjct: 1041 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD 1100
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQS 1386
+L + E + ++ + + L ++ + +NK L+ +++
Sbjct: 1101 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE-HMET 1159
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
ER +L + + ++VK+ E LK K E I E++ +T ++L+
Sbjct: 1160 ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKI 1219
Query: 1447 SLALEKAEYEELTGKYELLEEE--HVVTKARLTVEKEQAQGEL--LHVQKELSTALGEIK 1502
+ K E + + E+ ++ L + Q E+ LH ++EL + E+
Sbjct: 1220 AHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVS 1279
Query: 1503 TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
QE + T+ ++A + E+ER RLN + + + E+++
Sbjct: 1280 ETQETMNELELLTEQSTTKDSTTLARI---------EMERLRLNEKFQESQEEIKSLTKE 1330
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
RD L+ + E ++KIQ SE +
Sbjct: 1331 RDNLKTIKEALEVKHDQLKEHIR--ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1388
Query: 1623 KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSA 1682
R E +M + L+ H+++ +E+D+ +++ E Q ++K K
Sbjct: 1389 FKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK-- 1446
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAE 1742
I + + EEE + L++Q E+ + E R+ S+ TE+ + + E +
Sbjct: 1447 EIVAKHLET--EEELKVAHCCLKEQ----EETINELRVNLSEKETEISTIQKQLEAINDK 1500
Query: 1743 MQSRLNE-YEEE 1753
+Q+++ E YE+E
Sbjct: 1501 LQNKIQEIYEKE 1512
Score = 92.7 bits (220), Expect = 1e-17
Identities = 236/1359 (17%), Positives = 520/1359 (38%), Gaps = 91/1359 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
K +DQ L +V++LR++ ++++K + I ++L NI Y+ + +++Q +
Sbjct: 548 KTKKDQENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTL 607
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
+ T D + E L + E++ +++ +T Q QL L A+ + +D
Sbjct: 608 FDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ--VD 665
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQ----------ADEYSSLRRELE--QTIKNCRVL 434
++++ ++ + +D D L +E+E + ++ +L
Sbjct: 666 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL 725
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGM-----QRENRIKELEQEVARSTEVA 489
+LK + ++L +E + ++L I D + +E+R++ L +E+ ++ +
Sbjct: 726 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 785
Query: 490 LRLQRELAEANSKFTGSNPSLM------KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ 543
Q + +F M K+ E ++++ + + L L+
Sbjct: 786 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 845
Query: 544 DSLE-READLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNK 602
L + +L+E+ R +E +Q+ ++ D+ + E +T +Q
Sbjct: 846 TELSYKTQELQEKTREVQERLNEMEQLK-----EQLENRDSTLQTVEREKTLITEKLQQT 900
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ + ++EK D L E Q D+ N LR +++ E
Sbjct: 901 LEEVKTL--TQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 958
Query: 663 SL-LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
++ L+ K +R+ + K + +K+ D L ++ + E
Sbjct: 959 TINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEI 1018
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK- 780
+RK+ L Q+K L++ ++ + ++ + KT N L +E K
Sbjct: 1019 IEQQRKIFSLIQEKNELQQMLESVIAEKEQL-KTDLKENIEMTIENQEELRLLGDELKKQ 1077
Query: 781 --VLEDEIDEVRKKLIEKERDCERL-HAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
++ E + KK E R C+RL E L +K + K + L ++ ++++++
Sbjct: 1078 QEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1137
Query: 838 QVIEQEASVLRAKTQSLE-ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
IE + L+ K +LE + E+L+ K + + KS+ ++ + +K+ E E
Sbjct: 1138 NEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKS--FETE 1195
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATK-KET-DTLKSKQXXXXXXXXXXXXXXXXX 954
I+E+E K E K+ + +ET D L+
Sbjct: 1196 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSH 1255
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q + L + ++ P + + T +L+ + E + A +
Sbjct: 1256 TKLQEEIPVLHE--EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTL-----ARIEM 1308
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKY 1073
+ + K ++ +EI+S L+K K L+ + +LK+ + L ++ + +
Sbjct: 1309 ERLRLNEKFQESQEEIKS-LTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1367
Query: 1074 KALE-NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXX 1132
++L E N + + + E+ K +++ + ++ ++ + D M
Sbjct: 1368 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1427
Query: 1133 XXXXXXXXXXXXQVDNYTKIDQDKNKLLKE--------VGDKTKKIGDXXXXXXXXXXXC 1184
Q+ K K+ +E + ++ + I +
Sbjct: 1428 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1487
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVV--LANTHRRLSIELTSEKDELQARFIKTES 1242
I+KQL D++ Q + ++ +++ EL K+ +A+ +S
Sbjct: 1488 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVN-ELKQFKEHRKAK----DS 1542
Query: 1243 KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
++E++M +L + ++ I K+ +K++++AL Q D+ E T +
Sbjct: 1543 ALQSIESKMLELTNRLQESQEEIQIMIKEKE-EMKRVQEAL-QIERDQLKENTKEIVAKM 1600
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+E ++E + + KL + ++++ +L
Sbjct: 1601 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1660
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKL-DRMRIAHDKDVKNKDAELATLKGKLKILEQ 1421
+ + ++ L+ ER +L + +R +D++ K EL + LK ++
Sbjct: 1661 MRSVTKE----RDDLRSVEETLKVERDQLKENLRETITRDLE-KQEELKIVHMHLKEHQE 1715
Query: 1422 NSGAGAKRITELKQEYEETVKKLEHSLALEKAE----YEEL-TGKYELLEEEHVVTKAR- 1475
++E E K LEHS KA+ EEL L E++ + K R
Sbjct: 1716 TIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRG 1775
Query: 1476 LTVEK----EQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWN-TEK--TEMQNSIAS 1528
+ EK Q +L + +L + E+K + +L T N T+K +EM+
Sbjct: 1776 IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1835
Query: 1529 LQER-LCGGGWEVERARLNARLDQRERELRAANDRRDVL 1566
++++ L E+E L +L + E+++ RD L
Sbjct: 1836 IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL 1874
Score = 81.8 bits (193), Expect = 2e-14
Identities = 138/702 (19%), Positives = 306/702 (43%), Gaps = 61/702 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ +E Q++I+ L +E D L+ E +E K D L + + + + + L
Sbjct: 1313 LNEKFQESQEEIKSLTKERDNLKTIKEALEV-KHDQLKEHIRETLAKIQESQSKQEQSLN 1371
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIR-EIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+++K NE T ++ K + +R EIE L + +++ + + + L
Sbjct: 1372 MKEKDNETTKIVSEMEQFKPKDSALLRIEIEM-LGLSKRLQESHDEMKSVAKEKDDLQRL 1430
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR------EDQADEYSSLRRELEQTIKNCRVL 434
E L E++ +K+ ++++ ++ + ++Q + + LR L + +
Sbjct: 1431 QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI 1490
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+L+ K QE E E++ I + ++ N +K+ ++ ++
Sbjct: 1491 QKQLEAINDKLQNKIQEIYEKEEQF-NIKQISEVQEKVNELKQFKEHRKAKDSALQSIES 1549
Query: 495 ELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLT--RGGSQEDPAQLLRDLQDSLEREAD 551
++ E ++ S + + + + E +K + +L R +E+ +++ +++S E+E
Sbjct: 1550 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1609
Query: 552 LREQLRNAEEETANCKQVN-PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+ E + C+ + F +++ +NI T E+ +T + + S
Sbjct: 1610 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET----ENIRLTQILHENLEEMRSV- 1664
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+KE+ D ++ EET L + NLR+T R E E L ++
Sbjct: 1665 -TKERDDL------RSVEET--------LKVERDQLKENLRETITRDLEKQEEL--KIVH 1707
Query: 671 MATKARSRKLSPTPPANKLSIETAND--NDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
M K + + E N+ N +K+ + ++ A L++ E E + +
Sbjct: 1708 MHLKEHQETIDKL---RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE-ELRIAHMHL 1763
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR---RSLTTNSNKLAEERVKVLE-- 783
+E ++ + L+ V E T K+S++ K SN + + L N ++L + V E
Sbjct: 1764 KEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQ 1823
Query: 784 ---DEIDEVRKKLIEKERDCERLHAE-LSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
E+++++K++ ++ +L E L+LAQK + L + +S+ ++ N L+R +
Sbjct: 1824 KKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSV-MKERDN--LRRVEET 1880
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
++ E L+ Q +A + ++Q E K ++L DK + ++KT Q+ ++++
Sbjct: 1881 LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS-DIQK 1939
Query: 900 ALAKIKELEMICQDE-----KSEKKVRFTEATKKETDTLKSK 936
L K K+ QD K EK++ ++ + T++L+ K
Sbjct: 1940 DLDKSKDELQKKQDRQNHQVKPEKRL-LSDGQQHLTESLREK 1980
Score = 79.0 bits (186), Expect = 2e-13
Identities = 161/871 (18%), Positives = 366/871 (42%), Gaps = 67/871 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q++ +K+E ++ R C+R+ E + L + + + E+ ++Q+K+NE+
Sbjct: 1083 QEKNHAIKKEGELSRT-CDRLA-EVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1140
Query: 330 TTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQLRAKLLAAETLCEELMDEN 388
E+L++E K+ + +E+E LE +++ + + + L + E
Sbjct: 1141 ----ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETER 1196
Query: 389 EDMKKELRDLXXXXXXMQDNFR------EDQADEYSSLRRELEQTIKNCRVLSFK-LKKT 441
+ ++ +R++ ++ + ++ + LRR + + K ++++ + L+K+
Sbjct: 1197 DHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE--KTAQIINTQDLEKS 1254
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL-EQEVARSTEVALRLQRELAEAN 500
K + E ++ L + + + N ++ L EQ + + R++ E N
Sbjct: 1255 HTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLN 1314
Query: 501 SKFTGSNPSLMKVPQP-ETVKVSRSSLTRGGSQ--EDPAQLLRDLQDSLEREADLREQLR 557
KF S + + + + +K + +L Q E + L +Q+S ++ + L
Sbjct: 1315 EKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQ---EQSLN 1371
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E++ K V+ +Q + I E E + S + + H +KEK D
Sbjct: 1372 MKEKDNETTKIVSEM----EQFKPKDSALLRI-EIEMLGLSKRLQESHDEMKSVAKEKDD 1426
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
L +E Q ++ + + H+ K A ++ E + +L+ ++ +
Sbjct: 1427 LQRLQEVLQSESDQLKENIKEI-VAKHLETEEELKVAHCCLKEQEETINELRVNLSE-KE 1484
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEA 737
++S + +E ND + + E E + N ++ + ++ KV EL+Q KE
Sbjct: 1485 TEISTI----QKQLEAINDKLQNKIQEIYEKEE----QFNIKQISEVQEKVNELKQFKEH 1536
Query: 738 LKKQ---VKELTSKISSVTKTSAGSNTTARRSLTTNSN-KLAEERVKVLEDEIDEVRKKL 793
K + ++ + SK+ +T S + + K +E +++ D++ E K++
Sbjct: 1537 RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI 1596
Query: 794 IEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS 853
+ K ++ + + +T K ++ +Q K L+ IE E L TQ
Sbjct: 1597 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRL---TQI 1653
Query: 854 LEADNEKLQTENKKLQLLKNAK-SLRSDK-ALDLNTKKTTQLENELKEALAKIKELEMIC 911
L + E++++ K+ L++ + +L+ ++ L N ++T + E +E L KI + +
Sbjct: 1654 LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEEL-KIVHMHLKE 1712
Query: 912 QDEKSEK-KVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
E +K + +E T + ++ K + LK ++ K
Sbjct: 1713 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1772
Query: 971 -----SFKP-RIPKKPTDL-TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
S K ++ DL + +L++ +++L+ ++ + K+ + K+++ +L
Sbjct: 1773 LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQL 1832
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
+K+I + LSK + E N +L + ++K V ++D + L+ E
Sbjct: 1833 KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMK----ERDNLRRVEETLKLER--- 1885
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSL 1114
+Q K +E K R+ +I + +LK A L
Sbjct: 1886 -DQLKESLQETKARDLEIQQ---ELKTARML 1912
Score = 70.9 bits (166), Expect = 4e-11
Identities = 237/1274 (18%), Positives = 502/1274 (39%), Gaps = 107/1274 (8%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
V+E +++E LK++++ + VE+EK+ I + ++ EV L Q+
Sbjct: 862 VQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLE-----------EVKTLTQE 910
Query: 326 VNELTTHNEDLRDEKKHLTQKIRE-IESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
++L E L+ E+ L I + + ++T+ E +E L+ TL ++
Sbjct: 911 KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQ---EQLRNALESLKQHQETINTLKSKI 967
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQA--DEYSSLRRELEQTIKNCRVLSFKLKKTE 442
+E++ + L + +D F++ D+ L + QT+ V ++ + +
Sbjct: 968 ---SEEVSRNLH-MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL-TADVKDNEIIEQQ 1022
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQ---RENRIKELE-QEVARSTEVALRLQRELAE 498
RK L QEK E ++ L ++ + ++ +EN +E QE R L+ Q+E+
Sbjct: 1023 RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVA 1082
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
+ +V + ++ Q L ++Q+ + ++ N
Sbjct: 1083 QEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIEN 1142
Query: 559 AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDS 618
+ E N K++ +++ + + E +++T + S + ++
Sbjct: 1143 LKNELKN-KELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1201
Query: 619 PPLSIDKTTEETQFHFDLPYLSIFNHM-AANNLRKTAARVEEDNESLLLQ-LKKMATKAR 676
I+ T +T+ + ++ + H + LR++ + E+ + + Q L+K TK +
Sbjct: 1202 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS--EKTAQIINTQDLEKSHTKLQ 1259
Query: 677 SRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE 736
P ++ N + ET E M L L EQ T + +E ++
Sbjct: 1260 EE----IPVLHEEQELLPNVKEVSETQET----MNELELLTEQSTTKDSTTLARIEMERL 1311
Query: 737 ALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE---ERVKVLEDEIDEVRKKL 793
L ++ +E +I S+TK + T + +L ++L E E + +++ + + L
Sbjct: 1312 RLNEKFQESQEEIKSLTK-ERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSL 1370
Query: 794 IEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS 853
KE+D E + Q KP K +L + + + L ++LQ E + +
Sbjct: 1371 NMKEKDNETTKIVSEMEQFKP----KDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD 1426
Query: 854 LEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN-ELKEALAKIKELEMICQ 912
L+ E LQ+E+ QL +N K + A L T++ ++ + LKE I EL +
Sbjct: 1427 LQRLQEVLQSESD--QLKENIKEI---VAKHLETEEELKVAHCCLKEQEETINELRVNLS 1481
Query: 913 DEKSEKKVRFTEATKKETDTLKSK-QXXXXXXXXXXXXXXXXXXXXQATLKSLKD--DAQ 969
++++E + + D L++K Q LK K+ A+
Sbjct: 1482 EKETEIST-IQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK 1540
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
S I K +LT +LQ + E+++ I E + + + + +L++ E
Sbjct: 1541 DSALQSIESKMLELTNRLQ--ESQEEIQIMIKEKEEMKR---VQEALQIERDQLKENTKE 1595
Query: 1030 IRSKLSKN-DSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALEN-ENSNLSNQC 1087
I +K+ ++ + E+ K T + + ++ ++E K+ F + LEN E N+
Sbjct: 1596 IVAKMKESQEKEYQFLK---MTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI---- 1648
Query: 1088 KTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
LT+ + ++ ++ + + S++ T+ V
Sbjct: 1649 -RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVH 1707
Query: 1148 NYTKIDQDK-NKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXX 1206
+ K Q+ +KL V +KT +I + K + ++ + R+
Sbjct: 1708 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ-EELRIAHMHLKEQ 1766
Query: 1207 XXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLE 1266
+ R + E T + +Q + +K L+ ++++LKA+ E+++ +L+
Sbjct: 1767 QETIDKL------RGIVSEKTDKLSNMQKDLENSNAK---LQEKIQELKAN-EHQLITLK 1816
Query: 1267 STIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKI 1326
+ + ++E +Q + + +E + + E +N +
Sbjct: 1817 KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRR 1876
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQS 1386
E + E K + + K+ +++ K E +
Sbjct: 1877 VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISD 1936
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
+K LD+ + D+ K +D + +K + ++L G + +TE +E +K+L
Sbjct: 1937 IQKDLDKSK---DELQKKQDRQNHQVKPEKRLLSD----GQQHLTESLREKCSRIKEL-- 1987
Query: 1447 SLALEKAEYEELTGKYELLEEEHVVTKARLTVEKE-QAQGEL-LHVQKELSTALGEIKTL 1504
L++ Y E+ YE L + L +EKE + Q EL + V+ LS + K +
Sbjct: 1988 ---LKR--YSEMDDHYECL------NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHI 2036
Query: 1505 QEKLGTESAAWNTE 1518
EKL T + + E
Sbjct: 2037 -EKLFTANQRCSME 2049
Score = 45.6 bits (103), Expect = 0.002
Identities = 153/788 (19%), Positives = 306/788 (38%), Gaps = 50/788 (6%)
Query: 168 RVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKT-ARYKDERSSTKDDVNFLMQVK 226
R+ M L + Q + +K I E+ + + K+ E + A+ +++ K + + L+ +K
Sbjct: 1757 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1816
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXL-VDSNVKEYQDQIEGLKQEVDILRK 285
N T K L + + E ++++ + +E D LR+
Sbjct: 1817 KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRR 1876
Query: 286 RCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQ 345
E ++ E+ L+ A + + ++ K ++ T + LR++ T
Sbjct: 1877 VEETLKLERDQ--LKESLQETKARDLEIQQELKTARMLSKEHKETV--DKLREKISEKTI 1932
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
+I +I+ +L+ + E Q +Q Q ++ + L L D + + + LR+ +
Sbjct: 1933 QISDIQKDLD-KSKDELQKKQDRQ-NHQVKPEKRL---LSDGQQHLTESLREKCSRIKEL 1987
Query: 406 QDNFREDQADEYSSLRR---ELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEI 462
+ E D Y L R +LE+ I+ + LS ++K L + +H +KL
Sbjct: 1988 LKRYSE-MDDHYECLNRLSLDLEKEIEFQKELSMRVKANL----SLPYLQTKHIEKLFT- 2041
Query: 463 VGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVS 522
M+ +K+L+ ++ T++ + E E+ +KF + +V + + + +
Sbjct: 2042 ANQRCSMEFHRIMKKLKYVLSYVTKI----KEEQHESINKF--EMDFIDEVEKQKELLIK 2095
Query: 523 RSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN-AEEETANCKQVNPPTFLDKQVMT 581
L + + P++ LRDL+ + + + E L++ +E E + K +++ MT
Sbjct: 2096 IQHLQQ--DCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMT 2153
Query: 582 DNIVTC--DIHESETVTNSIQ--NKMIHAASTPSSKE----KSDSPPLSIDKTTEETQFH 633
+ + E + N IQ N I + + ++S T ++
Sbjct: 2154 QFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWE 2213
Query: 634 FDLPYLSIFNHMAANNLR--KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSI 691
DL L N N + KT+ K +R+ +L+ T +L
Sbjct: 2214 QDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLT-TEKIRELEN 2272
Query: 692 ETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS 751
+ E+ +M+ LE+ L+ KV E + E K+ ++ L K++
Sbjct: 2273 SLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVAL 2332
Query: 752 VTKTSAGSNTTARRSLTT-NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAE-LSL 809
K + L + K+ + K E EI K +E +++ RL E L
Sbjct: 2333 GAKPYKEEIEDLKMKLVKIDLEKM--KNAKEFEKEISAT-KATVEYQKEVIRLLRENLRR 2389
Query: 810 AQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQ 869
+Q+ T + S D I Q L K++ + + E + + + Q
Sbjct: 2390 SQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQ 2449
Query: 870 LLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKE 929
L+K L S+ N KT + E LK K ++ C++ KV T + KK+
Sbjct: 2450 LIKQKNELLSNNQHLSNEVKTWK-ERTLKREAHK----QVTCENSPKSPKVTGTASKKKQ 2504
Query: 930 TDTLKSKQ 937
+ K+
Sbjct: 2505 ITPSQCKE 2512
>AB002334-1|BAA20794.2| 1635|Homo sapiens KIAA0336 protein.
Length = 1635
Score = 98.7 bits (235), Expect = 2e-19
Identities = 262/1317 (19%), Positives = 524/1317 (39%), Gaps = 129/1317 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++++ KE++ +I L + + L K+CE EK +I + ++ K T+ + +
Sbjct: 210 IEASAKEHEAEINKLNELKENLVKQCEASEK---NIQKKYECELENLRKATSNANQDNQI 266
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETL 380
+ E T + + ++ KHL ++E+ES+ + + + L+ KL + A+ +
Sbjct: 267 CSILLQENTFVEQVVNEKVKHLEDTLKELESQ---HSILKDEVTYMNNLKLKLEMDAQHI 323
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK--NCRVLSFKL 438
+E E ED++ ++ +L Q E E + L ++ T++ N V S K
Sbjct: 324 KDEFFHEREDLEFKINELLLAKEE-QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE 382
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGM--QRENRIKELEQEVAR---STEVALRLQ 493
+ + ++ E ++ EK+ L ++ G+ Q EN +E ++ + E+ LQ
Sbjct: 383 QHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQ 442
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP-AQLLRDLQDSLEREADL 552
EL E+ K + S MK Q V + L +++D + + LQ E+
Sbjct: 443 TELGESAGKISQEFES-MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ 501
Query: 553 REQLRNAEEETANCKQVNPPTFL---DKQVMTDNI---VTCDIHESETVTNSIQNKMIHA 606
+E + E N ++ N L + M + + E + N ++N
Sbjct: 502 QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEM 561
Query: 607 ASTPSSKEKSDSPPLSIDKTTEET-QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
+ E+ + L + K E+T Q++ +L N + L +T +++++
Sbjct: 562 DNFHKKCEREERLILELGKKVEQTIQYNSELE--QKVNEL-TGGLEETLKEKDQNDQ--- 615
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
+L+K+ + + LS +++ + + K + E L + L+++E +L+
Sbjct: 616 -KLEKL--MVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 672
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
+ +LE+ + + ++ L + + T L ++++E+ E +
Sbjct: 673 EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSE---EKD 729
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV----DLKRQLQVIE 841
+ V + + E L+ Q+ K L + + +++V +LK L+ E
Sbjct: 730 VVNVLQAVGESLAKINEEKCNLAF-QRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE 788
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
QE +LR + + ++++ E LQ++ L +KNA N K T+LEN+ L
Sbjct: 789 QEKVLLRKELEEIQSEKEALQSD---LLEMKNA-----------NEK--TRLENQ--NLL 830
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
+++E+ C KSE + KE + LK +A L
Sbjct: 831 IQVEEVSQTC--SKSEIHNEKEKCFIKEHENLKP------------LLEQKELRDRRAEL 876
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKT 1021
LKD KS P + P L++ +L++ +E+LE E E K ++ ++ A
Sbjct: 877 ILLKDSLAKS--PSVKNDP--LSSVKELEEKIENLEKECKE-----KEEKINKIKLVA-V 926
Query: 1022 KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENS 1081
K +KE+D R + E + ++ A ++D+ ++G A YK L E
Sbjct: 927 KAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDL---IQG-----AESYKNLLLEYE 978
Query: 1082 NLSNQCKTLTEEMKNREAQINKLSADLKNAT-SLQTTMSDCMXXXXXXXXXXXXXXXXXX 1140
S Q E N E +I L+ L+N+T +T SD
Sbjct: 979 KQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEV 1038
Query: 1141 XXXXQVDNYTKIDQ--DKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+D+ + KL KE K K+ ++ +KQL +
Sbjct: 1039 QILEVQRAKAMVDKELEAEKLQKE--QKIKEHATTVNELEELQVQLQKEKKQLQKTMQEL 1096
Query: 1199 TXXXXXXXXXXXQAVVLANTHR---RLSIELTSEKDELQ--ARFIKTE-SKFITLEAEMR 1252
+ +A+ R L+ +LT++ ++++ + IK + K TL+ E+
Sbjct: 1097 ELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEIT 1156
Query: 1253 DLKA---DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
L++ YE K T ++ + K+L D+ + T+ +A+ E+ +
Sbjct: 1157 SLQSSVQQYEEKNTKIKQLLVKTK---KELADSKQAETDHLILQASLKGELEASQQQVEV 1213
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
E + L KT AE L Q + A E
Sbjct: 1214 YKIQLAEITSEKHKIHEHL-KTSAEQHQRTLSAYQQRV-TALQEECRAAKAEQATVTSEF 1271
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAHDK-DVKNKDAELATLKGKLKILEQNSGAGAK 1428
SY K + + Q + K + + K + ++ + + LK KL+ + N
Sbjct: 1272 ESY---KVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVS 1328
Query: 1429 RITELKQEYE---ETVKKLEHSLALEKAEYEE----LTGKYELLEEEHVVTKARLTVEKE 1481
+ L+ E++ E K+ ++AE E + + +++ EH T ++LT + E
Sbjct: 1329 ELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNE 1388
Query: 1482 ----QAQGELLHVQKELSTALGEIKTLQEKLG-TESAAWNTEKTEMQNSIASLQERL 1533
+ ++ H+Q+E ++TLQ++L E+ + + S S Q+ L
Sbjct: 1389 VLRNSFRDQVRHLQEEHRKT---VETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSL 1442
Score = 72.5 bits (170), Expect = 1e-11
Identities = 232/1298 (17%), Positives = 481/1298 (37%), Gaps = 88/1298 (6%)
Query: 263 DSNVKEYQDQIE----GLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSE 318
+ NVK+ Q++IE G ++++ L+K+ + EK + + + L NI AN ++
Sbjct: 128 EDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQ-LQNIIEANSQHYQKN-- 184
Query: 319 VLKLQQKVNELTT-HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
+ LQ+++ +L H E++++ + +E E+E+ E + ++Q A
Sbjct: 185 INSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKL--NELKENLVKQCEASEKNI 242
Query: 378 ETLCE-ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
+ E EL + + +D +Q+N +Q + + LE T+K
Sbjct: 243 QKKYECELENLRKATSNANQDNQICSILLQENTFVEQV--VNEKVKHLEDTLKELESQHS 300
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
LK + L+ K E + + ++ + E +I EL V +L+ EL
Sbjct: 301 ILKDEVTYMNNLKL-KLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSEL 359
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
A N +F + + Q SL +E L DS + + L ++
Sbjct: 360 AGLNKQFCYTVEQHNREVQ---------SLKEQHQKEISELNETFLSDSEKEKLTLMFEI 410
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTD--NIVTCDIHESE-TVTNSIQN-KMIHAASTPSS 612
+ +E+ N +Q L+ + + + I+ ++ ES ++ ++ K A+
Sbjct: 411 QGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHEL 470
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
++K + D E + L T ++E N LL L +
Sbjct: 471 QQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRD 530
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE 732
T + + N L+ E + ++ + + E E+ L +KVE+
Sbjct: 531 TMLKELE----GKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTI 586
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
Q L+++V ELT + K N L L+E++ +VL E+ K
Sbjct: 587 QYNSELEQKVNELTGGLEETLKEK-DQNDQKLEKLMVQMKVLSEDK-EVLSAEV----KS 640
Query: 793 LIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
L E+ L+ +K K L + + S +++V LK + +E++ ++ +
Sbjct: 641 LYEENN---------KLSSEK-KQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQD 690
Query: 853 SLEA--DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
+L +NE++Q K QL K + S+ + D K + + E+LAKI E +
Sbjct: 691 NLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCN 750
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
++ EK + +KE +K Q + L+ ++ Q
Sbjct: 751 LAFQRDEKVLEL----EKE---IKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQ- 802
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEI 1030
S K + +DL L++K E E + + ++ + +K+++ E ++
Sbjct: 803 SEKEALQ---SDL---LEMKNANEKTRLENQNLLIQVEEVS----QTCSKSEIHNEKEKC 852
Query: 1031 RSKLSKNDSEFTNEKNRL--QTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
K +N +K + E+ LKD AK K+ + K LE + NL +CK
Sbjct: 853 FIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECK 912
Query: 1089 TLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN 1148
E++ + K +L ++ T+ + + N
Sbjct: 913 EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 972
Query: 1149 ----YTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
Y K + + + + +I D C+ I R+
Sbjct: 973 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSN 1032
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDELQARF---IKTESKFITLEAEMRDLKADYENK 1261
Q + + + EL +EK + + + T ++ L+ +++ K +
Sbjct: 1033 AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKT 1092
Query: 1262 ITSLESTIA-AKDVHIKQLE----DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ LE A+ + +E + L + N K + +E +E
Sbjct: 1093 MQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE--IKIQKQKQET 1150
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENK 1376
Q+E+ + + +++ E +++ K + + K +LA + + +
Sbjct: 1151 LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQ 1210
Query: 1377 AKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQE 1436
+ L + ++ + L+ + ++ L++ A + E
Sbjct: 1211 VEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSE 1270
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELST 1496
+ E+ K H++ ++ + E ++E + L + +Q + +L Q L
Sbjct: 1271 F-ESYKVRVHNVLKQQKNKSMSQAETEGAKQE----REHLEMLIDQLKIKLQDSQNNLQI 1325
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLC 1534
+ E++TLQ + T N E + A L+E+LC
Sbjct: 1326 NVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLC 1363
Score = 68.5 bits (160), Expect = 2e-10
Identities = 237/1293 (18%), Positives = 504/1293 (38%), Gaps = 120/1293 (9%)
Query: 321 KLQQKVNELTTH--NEDLRDEKKHLTQKI-----REIESELETRPSTEAQTRQIEQLRAK 373
+L++++ EL + E D K LT+++ + E+E + + + +++
Sbjct: 1 ELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDS 60
Query: 374 LLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRV 433
+ +EL + + KE+ +L ++ + ED+A +L+++LE+ +
Sbjct: 61 VTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKA----NLQKQLEEAMNTQLE 116
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
LS +LK D +++ + E EK I G + Q K+L+ E +LQ
Sbjct: 117 LSEQLKFQNNSEDNVKKLQEEIEK----IRPGFE-EQILYLQKQLDATTDEKKETVTQLQ 171
Query: 494 RELAEANSKFTGSN-PSL------MKVPQPETVKVSRSSLTRGGSQEDPAQL--LRDLQD 544
+ EANS+ N SL +K E VK + ++E A++ L +L++
Sbjct: 172 -NIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQI-EASAKEHEAEINKLNELKE 229
Query: 545 SLEREADLRE---------QLRNAEEETANCKQVNP--PTFLDKQVMTDNIVTCDI-HES 592
+L ++ + E +L N + T+N Q N L + + +V + H
Sbjct: 230 NLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLE 289
Query: 593 ETV-----TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAA 647
+T+ +SI + + K + D+ + + E F + L +
Sbjct: 290 DTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQG 349
Query: 648 NNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDND-EKETDEAD 706
+ K + + N+ +++ + +S K ++L+ +D++ EK T +
Sbjct: 350 CVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFE 409
Query: 707 PAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS 766
+K E +QE E L + E L+ ++ E KIS ++ +
Sbjct: 410 IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHE 469
Query: 767 LTTNSNKLAEERVKVLE--DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
L E+ +LE + + +KL+ ++ L + Q+K + S S
Sbjct: 470 LQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQR 529
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
+ + ++ K E++ + + K E DN + E ++ +L+ K + ++ +
Sbjct: 530 DTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKV--EQTIQ 587
Query: 885 LNTKKTTQLENELKEALAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
N+ + Q NEL L + +KE + D+K EK + + ++ + L ++
Sbjct: 588 YNS-ELEQKVNELTGGLEETLKEKDQ--NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE 644
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
S K+D K I T L KLQL MVE+ + +
Sbjct: 645 NNKLSSEKKQLSRDLEVFLSQKEDV--ILKEHI----TQLEKKLQL--MVEEQD----NL 692
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT---EIAKLKDVNA 1060
+++N + +++ KT+L + E+ S++S+ DSE + N LQ +AK+ +
Sbjct: 693 NKLLENEQV--QKLFVKTQLYGFLKEMGSEVSE-DSEEKDVVNVLQAVGESLAKINEEKC 749
Query: 1061 KLEGDKD----VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN-ATSLQ 1115
L +D + K L+ E+ + K+L + + + + K ++++ +LQ
Sbjct: 750 NLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQ 809
Query: 1116 TTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI---GD 1172
+ + + M Q + ++I +K K + + K + +
Sbjct: 810 SDLLE-MKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKE 868
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-IELTSEKD 1231
+ K S + D ++ +++ I+L + K
Sbjct: 869 LRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKA 928
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKY 1291
+ + + E++ T++ E+ L+++ + S+ I + + L + +Q +++
Sbjct: 929 KKELDSSRKETQ--TVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQ--SEQL 984
Query: 1292 DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAK-----IKLEKTEAESSAAKLEMAQLK 1346
D E R Q E N+ ++E ++ + ++++ +++
Sbjct: 985 DVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ 1044
Query: 1347 SDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKD 1406
A ++ + N+ +EL LQ E+K+L + + ++ KD
Sbjct: 1045 RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQL--QKTMQELELVKKD 1102
Query: 1407 AELATLKGK--------LKILEQNSGAGAKRITELKQEY------EETVKKLEHSLALEK 1452
A+ TL +K L Q +I +L+QE +ET+++ SL
Sbjct: 1103 AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSV 1162
Query: 1453 AEYEELTGKYELL--------------EEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
+YEE K + L E +H++ +A L E E +Q ++ + +L+
Sbjct: 1163 QQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEIT 1222
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEMQNSIASLQE 1531
E + E L T + + Q + +LQE
Sbjct: 1223 SEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1255
Score = 55.6 bits (128), Expect = 2e-06
Identities = 120/679 (17%), Positives = 287/679 (42%), Gaps = 48/679 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
+E + + +QE +LRK E ++ EK + L L + AN+ T + +L ++V
Sbjct: 778 EELKSLLRDYEQEKVLLRKELEEIQSEK-EALQSDLLEMKNANEKTRLENQNLLIQVEEV 836
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL------ 380
++ + +E +++K ++ ++ LE + + + I L+ L + ++
Sbjct: 837 SQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELI-LLKDSLAKSPSVKNDPLS 895
Query: 381 -CEELMDENEDMKKELRDLXXXXXXMQ------DNFREDQADEYSSLRRELEQTIKNCRV 433
+EL ++ E+++KE ++ ++ + E +++ ELE
Sbjct: 896 SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQ 955
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEI-VGGPDGMQRENRIKELEQEVARSTEVALRL 492
LS ++ + A+ + E+EK+ ++ V E+RI++L +++ ST +
Sbjct: 956 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1015
Query: 493 QRELAE--ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE--DPAQLLRDLQDSLER 548
+ + A + SN L++V E V+ +++ + + E Q +++ ++
Sbjct: 1016 NSDNEDLLARIETLQSNAKLLEVQILE-VQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1074
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
+L+ QL+ +++ K + + K ++ +I + E + + K+ + +
Sbjct: 1075 LEELQVQLQKEKKQLQ--KTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNN 1132
Query: 609 TPSSKEKSDSPPLSIDKTTEE--TQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
E+ +T +E T + N L KT + + ++
Sbjct: 1133 KIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETD 1192
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
L A+ + S I+ A EK +K E +++ + ++
Sbjct: 1193 HLILQASLKGELEASQQQ-VEVYKIQLAEITSEKHKIHE---HLKTSAEQHQRTLSAYQQ 1248
Query: 727 KVEELEQDKEALKKQVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
+V L+++ A K + +TS+ S + +S++ + A++ + LE
Sbjct: 1249 RVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEML 1308
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK--SRSLDASDQQNVDLKRQLQVIEQE 843
ID+++ KL + + + + +EL Q + TL++ ++ L + + +L+ +L I+ E
Sbjct: 1309 IDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSE 1368
Query: 844 ASVLRAK-TQS---LEADNE-----------KLQTENKK-LQLLKNAKSLRSDKALDLNT 887
+++++ TQ+ L + NE LQ E++K ++ L+ S + L
Sbjct: 1369 NMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKN 1428
Query: 888 KKTTQLENELKEALAKIKE 906
+ TT+ +++L ++E
Sbjct: 1429 EPTTRSPVSSQQSLKNLRE 1447
Score = 51.6 bits (118), Expect = 3e-05
Identities = 201/1137 (17%), Positives = 434/1137 (38%), Gaps = 101/1137 (8%)
Query: 689 LSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSK 748
LS++ N ++E +++ EL + ++ ++E L+ + A++ + E +
Sbjct: 44 LSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVK-EIENLKNELMAVRSKYSEDKAN 102
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS 808
+ + + + L +N +E+ VK L++EI+++R E+ ++ + +
Sbjct: 103 LQKQLEEAMNTQLELSEQLKFQNN--SEDNVKKLQEEIEKIRPGFEEQILYLQK-QLDAT 159
Query: 809 LAQKKPKTLIKSRSLDASDQ---QNVDLKR----QLQVIEQEASVLRAKTQSLEADNEKL 861
+KK ++A+ Q +N++ + QL+ I QE ++ +EA ++
Sbjct: 160 TDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEE--VKELMCQIEASAKEH 217
Query: 862 QTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE-LKEALAKIKELEMICQ---DEKSE 917
+ E KL LK ++ +A + N +K + E E L++A + + IC E +
Sbjct: 218 EAEINKLNELKE-NLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTF 276
Query: 918 KKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIP 977
+ E K DTLK + + + +KD+ F R
Sbjct: 277 VEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF---FHER-- 331
Query: 978 KKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSK 1036
DL K+ +L E+ C I ++ + AGL+ + + +E+ ++ + K
Sbjct: 332 ---EDLEFKINELLLAKEEQGCVIEKLKSEL--AGLNKQFCYTVEQHNREVQSLKEQHQK 386
Query: 1037 NDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
SE NE +E KL + +++G K+ N L+ E ++L E M+
Sbjct: 387 EISEL-NETFLSDSEKEKLT-LMFEIQGLKEQCEN----LQQEKQEAILNYESLREIMEI 440
Query: 1097 REAQINKLSADLKNA-TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQD 1155
+ ++ + + + S++ + + ++ +
Sbjct: 441 LQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLS 500
Query: 1156 KNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVL 1215
+ +L+ E+ + K + + + K+L + + +T L
Sbjct: 501 QQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINK------L 554
Query: 1216 ANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITS-LESTIAAKDV 1274
N+H + + +K E + R I K + + N++T LE T+ KD
Sbjct: 555 KNSHEEM--DNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQ 612
Query: 1275 HIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAE 1334
+ ++LE + Q D+ E+ + ++L++ K +L + + E
Sbjct: 613 NDQKLEKLMVQMKVLSEDKEVLSAEVKSL-----------YEENNKLSSEKKQLSR-DLE 660
Query: 1335 SSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM 1394
++ E LK + +LE + + + T L K++
Sbjct: 661 VFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGS- 719
Query: 1395 RIAHDKDVKNKDAELATLKGKL-KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKA 1453
++ D + K+ L + L KI E+ +R E E E+ +K L+ ++
Sbjct: 720 EVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQR-DEKVLELEKEIKCLQEESVVQCE 778
Query: 1454 EYEELTGKYELLEEEHVVTKA--RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
E + L YE +E+ ++ K + EKE Q +LL ++ E + L + E
Sbjct: 779 ELKSLLRDYE--QEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLL--IQVE 834
Query: 1512 SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAAND--RRDVLEHH 1569
+ K+E+ N ++ C + E L L+Q+E R A +D L
Sbjct: 835 EVSQTCSKSEIHN-----EKEKC---FIKEHENLKPLLEQKELRDRRAELILLKDSLAKS 886
Query: 1570 HDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR---KAEI 1626
E + K + ++ S K K E+
Sbjct: 887 PSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEEL 946
Query: 1627 TDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQM-LEAAQKSMAEIKNGDKSARIH 1685
++ + +MRD ++ + + +Q+ +E + + E + D + ++
Sbjct: 947 ESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLR 1006
Query: 1686 RNSIS----STDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLA 1741
+++ ++D E+ ++ L+ LE ++ E + + ++ EL +EK E ++
Sbjct: 1007 NSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1066
Query: 1742 EMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
E + +NE EE +++ KE+ + Q+ +QE + +D +QT
Sbjct: 1067 EHATTVNELEE-----------------LQVQLQKEKKQLQKTMQELELVKKDAQQT 1106
Score = 38.3 bits (85), Expect = 0.28
Identities = 58/342 (16%), Positives = 133/342 (38%), Gaps = 23/342 (6%)
Query: 162 NDSLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKE--DEKTARYKDERSSTKDDV 219
N L + K++ L+ + +K+ + E SL S + +EK + K TK ++
Sbjct: 1124 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKEL 1183
Query: 220 NFLMQVKNSRN--STNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVK----EYQDQI 273
Q + +LK + + ++K ++Q +
Sbjct: 1184 ADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1243
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
+Q V L++ C + E++ + Y R VLK Q+ +
Sbjct: 1244 SAYQQRVTALQEECRAAKAEQATVT-------SEFESYKV-RVHNVLKQQKNKSMSQAET 1295
Query: 334 EDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMK 392
E + E++HL I +++ +L +++ + + +++ L+++ +++ E +
Sbjct: 1296 EGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKE 1355
Query: 393 KELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK-ADQLEQE 451
ELR+ + + S L + E + R L++ RK + L+Q+
Sbjct: 1356 AELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQ 1415
Query: 452 KAEHEKKLLEIVGGP---DGMQRENRIKELEQEVARSTEVAL 490
++ E +L ++ P + + +K L + R+T++ L
Sbjct: 1416 LSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRER--RNTDLPL 1455
>BC132736-1|AAI32737.1| 1843|Homo sapiens KIAA1212 protein.
Length = 1843
Score = 97.1 bits (231), Expect = 6e-19
Identities = 177/862 (20%), Positives = 352/862 (40%), Gaps = 82/862 (9%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
QI+ L+QE + L + + + R+ +I+ NK + + K++++
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL---HESIKETSSKLSKIEF 608
Query: 332 HNEDLRDEKKHLTQK---IREIESELE-TRPSTEAQTRQIEQLRA---KLLAAETLCEEL 384
++ E +H +K E+E+EL E ++I L+ K+ A E EL
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
EN +KK L ++ +E+ + +L EL + +++ + S K+ + + +
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVESLKCASMKMAQLQLE 726
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
+LE EK E KK LE++ ++ R++ Q + + RLQ+ L +N K
Sbjct: 727 NKELESEK-EQLKKGLELLKA--SFKKTERLEVSYQGLDIENQ---RLQKTLENSNKKIQ 780
Query: 505 GSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLRNAEEE 562
L + + +T++ + L + + QL ++ SLE+E + L + + E+E
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLE--QLEKE-NKSLEQETSQLEKDKKQLEKE 837
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIH-ESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
+Q D + +N+ ++ E++T++ I I+ S KE
Sbjct: 838 NKRLRQ--QAEIKDTTLEENNVKIGNLEKENKTLSKEIG---IYKESCVRLKELEKENKE 892
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+ + T D+ L + KT ++ D E L +L+K+ + R L
Sbjct: 893 LVKRAT------IDIKTLVTLREDLVSEKLKTQ-QMNNDLEKLTHELEKIGLN-KERLLH 944
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
++ +D+ K + + +K LE+ E++ L ++EE + L+++
Sbjct: 945 DE--------QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE 996
Query: 742 VKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE 801
+K + ++ + + + E + E+ +V+ +LIE ER+
Sbjct: 997 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1056
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
L AE K +K++ L + QN +L+ Q+ ++++ T SL+ N L
Sbjct: 1057 TLQAE--------KQALKTQ-LKQLETQNNNLQAQILALQRQ-------TVSLQEQNTTL 1100
Query: 862 QTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVR 921
QT+N KLQ+ + LN++ T+ L N+ + L + LE ++E ++
Sbjct: 1101 QTQNAKLQVENST----------LNSQSTS-LMNQNAQLLIQQSSLE-----NENESVIK 1144
Query: 922 FTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPT 981
E K D+L TLKS + + + +
Sbjct: 1145 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1204
Query: 982 DLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEF 1041
L K QL+ + + L+ E +M + KN E ++ S+L K
Sbjct: 1205 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1264
Query: 1042 TNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTE-----EMKN 1096
+ L++ + K +LE + +Y+ L+ ++ L+NQC+ L++ E +N
Sbjct: 1265 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1324
Query: 1097 REAQINKLSADLKNATSLQTTM 1118
R + L+N T L+ M
Sbjct: 1325 RHLLDQIQTLMLQNRTLLEQNM 1346
Score = 80.6 bits (190), Expect = 5e-14
Identities = 187/951 (19%), Positives = 371/951 (39%), Gaps = 84/951 (8%)
Query: 655 ARVEE--DNESLLLQLKKM------ATKARSRKLSPTPPAN-----KL-SIETANDNDEK 700
ARVEE ++ +LL+ K M T+ARS KL N KL +E D D K
Sbjct: 344 ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK 403
Query: 701 ETDEADPAEMKLLLELNEQ--EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ +E M L + + E+ L ++E++ + E + K L +++ +T +
Sbjct: 404 KIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLL 463
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
+SLT K EE ++ D ++ K+++ E++ +RL ++ + + + +
Sbjct: 464 KLEMENQSLT----KTVEE-LRTTVDSVEGNASKILKMEKENQRLSKKVEILENE--IVQ 516
Query: 819 KSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLKNA 874
+ +SL + DL ++ +E+ LR ++ LE +NE L N+ + L+
Sbjct: 517 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQR 573
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK 934
+ ++ + K+ L +KE +K+ ++E + + +K++ + + + L+
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEF--EKRQIKKELEHYKEKGERAEELE 631
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLK-DDAQKSFKPRIPKKPTD----LTTKLQ- 988
++ +++L+ ++++ + R KK D LT +L+
Sbjct: 632 NELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES 691
Query: 989 LKK---MVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNE 1044
L+K +++ E+ +K A + ++ + K LE E ++++ L + F +
Sbjct: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF-KK 750
Query: 1045 KNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
RL+ L N +L+ + K + LE+E +L + +TL + ++ + +L
Sbjct: 751 TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
Query: 1105 SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQV-DNYTKI---DQDKNKLL 1160
K SL+ S + +N KI +++ L
Sbjct: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCKRIE---KQLSTRKDRVTXXXXXXXXXXXQAVVLAN 1217
KE+G + KR K L T ++ + L +
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 1218 THRRLSIE----LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKD 1273
++ + L E+ +R+ ESK LE+ ++ E KI +LE+ +
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESK---LESTLKKSLEIKEEKIAALEARLEEST 987
Query: 1274 VHIKQLEDALR------QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK 1327
+ +QL L+ + + DE + EL K +
Sbjct: 988 NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1047
Query: 1328 LEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
L + E ++ + E LK+ L +LE + +E +T LQ++
Sbjct: 1048 LIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV----SLQEQNTTLQTQ 1103
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVK---KL 1444
KL + + + A L + LE + + K +LK Y+ +K KL
Sbjct: 1104 NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1163
Query: 1445 EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTL 1504
E + +EYE L K+ L+ H L VE + + K+ G+++ L
Sbjct: 1164 ELLHERQASEYESLISKHGTLKSAH----KNLEVEHRDLEDRYNQLLKQ----KGQLEDL 1215
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
++ L E E + ++A+ ++LCG E RLN Q +E
Sbjct: 1216 EKMLKVEQEKMLLE-NKNHETVAAEYKKLCG-----ENDRLNHTYSQLLKE 1260
Score = 79.0 bits (186), Expect = 2e-13
Identities = 182/874 (20%), Positives = 349/874 (39%), Gaps = 96/874 (10%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE----LETRPSTEAQTRQIEQLRA 372
+++ +L+Q++ E T D + E + + +++ ++ E L S +++ LR
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALRE 317
Query: 373 KLLAAETLCEEL------MDENEDMKKELRDLXXXXXXMQDN--FREDQADEYSSLRREL 424
K + + L E+ + + E K + +L + + EDQ + + +L
Sbjct: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377
Query: 425 EQTIKNCRVLSFKLK--KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV 482
+ K L KL + ER D+ + E+ E LE+ + + ELEQ +
Sbjct: 378 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ-I 436
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
+R++E++ Q+ L ++ T S +++ K T S E A + +
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 496
Query: 543 QDSLEREADLREQLRNA----EEETANCKQVNPPTFLDKQVMTDNIVTC----------- 587
+ +R + E L N ++ NC+ ++ +K + I T
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556
Query: 588 ---DIHESETVTNSIQNKMIHAASTPSSKEKSDSP-PLSIDKTTEE-TQFHFDLPYLSI- 641
+ H ++TV++ Q I A + EK + SI +T+ + ++ F+ +
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
Query: 642 FNHMA-----ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETAND 696
H A L +E++NE LLQ K K K+ N +E N
Sbjct: 617 LEHYKEKGERAEELENELHHLEKENE--LLQKKITNLKITCEKIEALEQENS-ELERENR 673
Query: 697 NDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTS 756
+K D + LE E+E + L + EL ++ E+LK ++ +++ K
Sbjct: 674 KLKKTLDSFK--NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM-AQLQLENKEL 730
Query: 757 AGSNTTARRSLTTNSNKLAE-ERVKV----LEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
++ L + ER++V L+ E ++K L + ++L +EL +
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL 871
+ +TL K+ ++ + KR L+ +E+E L +T LE D ++L+ ENK+L+
Sbjct: 791 MENQTLQKNL-----EELKISSKR-LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 872 KNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
K D L+ N K LE E K +I + C K +K E K+ T
Sbjct: 845 AEIK----DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-KELVKRATI 899
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD------LTT 985
+K+ + L+ + ++ TD L +
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLES 959
Query: 986 KLQ--LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK--------LEKEIDEIR---- 1031
KL+ LKK +E E +I + ++ + +++ + K L++ DE R
Sbjct: 960 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1019
Query: 1032 -SKLSKNDSEFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALENENSNL 1083
+S D+++ E E+ K+KD NA L+ +K + K LE +N+NL
Sbjct: 1020 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1079
Query: 1084 SNQC-----KTLTEEMKNREAQINKLSADLKNAT 1112
Q +T++ + +N Q ++N+T
Sbjct: 1080 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1113
Score = 63.3 bits (147), Expect = 9e-09
Identities = 199/1066 (18%), Positives = 408/1066 (38%), Gaps = 89/1066 (8%)
Query: 738 LKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER-VKVLEDEIDEVRKKLIEK 796
L+++++E T ++ + +R N N L++ R ++ DE+D +R+K +
Sbjct: 263 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVR- 321
Query: 797 ERDCERLHAELSLAQKKPKTL--IKSRSLDASDQQNVDLKRQLQVIEQ-EASVLRA-KTQ 852
++L +E+S +++ + K+R + + V L+ + + +Q E + R+ K
Sbjct: 322 ---VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQ 912
LE +N +L+ + +++ ++ + ++ ++ N + + E+L ELE I +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 438
Query: 913 DEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSF 972
SE ++ E + L S + + T+ S++ +A K
Sbjct: 439 T--SELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDSVEGNASKIL 494
Query: 973 KPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNA-GLSGKEMTAKTKLEKEIDEIR 1031
K + +L K VE LE EI + ++N LS M K +LEK I+ +R
Sbjct: 495 KMEKENQ--------RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR 546
Query: 1032 S------KLSKNDSEFTNE-----KNRLQTEI-AKLKDV---NAKLEGDKDVFANKYKAL 1076
K+ + ++E N+ + R Q A++KD+ N L ++K +
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ---TTMSDCMXXXXXXXXXXX 1133
E E + + + E+ + E N+L K LQ T +
Sbjct: 607 EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENS 666
Query: 1134 XXXXXXXXXXXQVDNYTKID------QDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRI 1187
+D++ + + +N L E + ++ + +
Sbjct: 667 ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE 726
Query: 1188 EKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITL 1247
K+L + K+++ + L +++ L IE LQ + K L
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE----NQRLQKTLENSNKKIQQL 782
Query: 1248 EAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVE----MVEM 1303
E+E++DL + EN+ +L+ + + K+LE ++ N ++ TS +E +E
Sbjct: 783 ESELQDL--EMENQ--TLQKNLEELKISSKRLEQLEKE--NKSLEQETSQLEKDKKQLEK 836
Query: 1304 RXXXXXXXXXXXXXQDELNNAKI-KLEKTEAESS-------AAKLEMAQLKSDLAKLENX 1355
E NN KI LEK S + + + +L+ + +L
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 1356 XXXXXXXXXXXXXXSSYWENKAKELDTDLQS-----ERKKLDRMRIAHDKDVKNKDAELA 1410
+ K ++++ DL+ E+ L++ R+ HD+ D+
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ-STDDSRYK 955
Query: 1411 TLKGKLK-ILEQNSGAGAKRITELKQEYEETV---KKLEHSLALEKAEYEELTGKYELLE 1466
L+ KL+ L+++ ++I L+ EE+ ++L L K YE L + + E
Sbjct: 956 LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQD--E 1013
Query: 1467 EEHVVTKARLTVEKEQAQGELLHVQKEL---STALGEIKTLQEKLGTESAAWNTEKTEMQ 1523
E V + ++ E + + E +EL L E++ L E A T+ +++
Sbjct: 1014 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1073
Query: 1524 NSIASLQERLCG-GGWEVERARLNARLDQRERELRAANDRRDVLEHH-HDXXXXXXXXXX 1581
+LQ ++ V N L + +L+ N + +
Sbjct: 1074 TQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS 1133
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMN--T 1639
+ E V K + E+ ++ I+ T N
Sbjct: 1134 SLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV 1193
Query: 1640 MRDELKSLHNQVSRFRRERDNYKQMLEAAQ-KSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
+L+ +NQ+ + + + ++ ++ML+ Q K + E KN + A ++ D +
Sbjct: 1194 EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1253
Query: 1699 NKVALLEQQVACLEDELCESRLLASKL-NTELVSEKSSAEVRLAEM 1743
L E +V + + +S L SKL T L +E S + + ++
Sbjct: 1254 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQL 1299
Score = 58.4 bits (135), Expect = 2e-07
Identities = 83/328 (25%), Positives = 150/328 (45%), Gaps = 37/328 (11%)
Query: 261 LVDSNVK--EYQDQIEGLKQEVDILRKRCERV---EKEKSDILLRRLANIDTANKYTTGR 315
L ++NVK + + + L +E+ I ++ C R+ EKE +++ R +I T
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 316 SSEVLKLQQKVNEL--TTH-------NED--LRDEKKHLTQKIREIESELETRPSTEAQT 364
SE LK QQ N+L TH N++ L DE+ + + +ES+LE ST ++
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE---STLKKS 968
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM---QDNFREDQAD-----E 416
+I++ K+ A E EE + N+ +++EL+ + + QD R Q+ E
Sbjct: 969 LEIKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026
Query: 417 YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
+ RE ++T + + +L + ER L+ EK + +L ++ + +Q + I
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ--IL 1084
Query: 477 ELEQEVARSTEVALRLQRELAE---ANSKFTGSNPSLMKVPQPETVKVSRSSL-TRGGSQ 532
L+++ E LQ + A+ NS + SLM Q + + +SSL S
Sbjct: 1085 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN--QNAQLLIQQSSLENENESV 1142
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAE 560
+ L+ L DSL ++ + E L +
Sbjct: 1143 IKEREDLKSLYDSLIKDHEKLELLHERQ 1170
Score = 43.2 bits (97), Expect = 0.010
Identities = 154/868 (17%), Positives = 311/868 (35%), Gaps = 40/868 (4%)
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMI-CQDEKSEKKVRFTEATKKETDTLKSKQX 938
+ DL + T + E E L K L + DE+ E E ++ E D L
Sbjct: 168 ENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE-ERDGLHFLPH 226
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLE 997
+ L DA+ + R+ ++ + T +L K+ +E +E
Sbjct: 227 ASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIR-RLRQELEEKTEQLLDCKQELEQME 285
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSK---LSKNDSEFTNEKNRLQTEIAK 1054
E+ + +N L +A+ + E+D +R K + K +SE + K RL +I
Sbjct: 286 IELKRLQ--QENMNLLSDARSARMYRD-ELDALREKAVRVDKLESEVSRYKERLH-DIEF 341
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSL 1114
K +L+ D V LE++ + L E++ Q+ D++ +
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL-HELEKENLQLKAKLHDMEMERDM 400
Query: 1115 -QTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI-GD 1172
+ + + M +++ ++ + K +G + ++
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+ ++L T D V + L+ L E+ EK
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520
Query: 1233 LQ--ARFIKTESKF-ITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
LQ K K LE + L+ + E +I LE ++ H+ Q +LRQ +
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ----ENEHLNQTVSSLRQRSQI 576
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
+ +E + E +IK E + + E +L+++L
Sbjct: 577 SAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE--ELENEL 634
Query: 1350 AKLENXXXXXXXXXXXXXXXSSY---WENKAKELDTDLQSERKKLDRMRI------AHDK 1400
LE E + EL+ + + +K LD + + +K
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK 694
Query: 1401 DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTG 1460
+ D E L+ ++ L+ S A+ E K E E ++L+ L L KA +++ T
Sbjct: 695 ENSQLDEENLELRRNVESLKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKK-TE 752
Query: 1461 KYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT-ESAAWNTEK 1519
+ E+ + + RL E + ++ ++ EL E +TLQ+ L + ++ E+
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 1520 TEMQN-SIASLQERLCGGGWEVERA--RLNARLDQRERELRAANDRRDVLEHHHDXXXXX 1576
E +N S+ +L ++E+ RL + + ++ L N + LE +
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 1577 XXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQ 1636
+ + K + + SEK + ++ + + +
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV-SEKLKTQQMNNDLEKLTHE 931
Query: 1637 MNTMR-DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEE 1695
+ + ++ + LH++ S + LE+ K EIK +A R S+ +
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991
Query: 1696 EYRNKVALLEQQVACLEDELCESRLLAS 1723
+ R ++ +++ L+ E R++ S
Sbjct: 992 QLRQELKTVKKNYEALKQRQDEERMVQS 1019
>AB201172-1|BAE44387.1| 1870|Homo sapiens girdin protein.
Length = 1870
Score = 97.1 bits (231), Expect = 6e-19
Identities = 178/862 (20%), Positives = 351/862 (40%), Gaps = 83/862 (9%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
QI+ L+QE + L + + + R+ +I+ NK + + K++++
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL---HESIKETSSKLSKIEF 608
Query: 332 HNEDLRDEKKHLTQK---IREIESELE-TRPSTEAQTRQIEQLRA---KLLAAETLCEEL 384
++ E +H +K E+E+EL E ++I L+ K+ A E EL
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
EN +KK L ++ +E+ + +L EL + +++ + S K+ + + +
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVESLKCASMKMAQLQLE 726
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
+LE EK E KK LE++ ++ R++ Q + + RLQ+ L +N K
Sbjct: 727 NKELESEK-EQLKKGLELLKA--SFKKTERLEVSYQGLDIENQ---RLQKTLENSNKKIQ 780
Query: 505 GSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLRNAEEE 562
L + + +T++ + L + + QL ++ SLE+E + L + + E+E
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLE--QLEKE-NKSLEQETSQLEKDKKQLEKE 837
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIH-ESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
+Q D + +N+ ++ E++T++ I I+ S KE
Sbjct: 838 NKRLRQ--QAEIKDTTLEENNVKIGNLEKENKTLSKEIG---IYKESCVRLKELEKENKE 892
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+ + T D+ L + KT ++ D E L +L+K+ + R L
Sbjct: 893 LVKRAT------IDIKTLVTLREDLVSEKLKTQ-QMNNDLEKLTHELEKIGLN-KERLLH 944
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
E + D+ K + + +K LE+ E++ L ++EE + L+++
Sbjct: 945 D---------EQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE 995
Query: 742 VKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE 801
+K + ++ + + + E + E+ +V+ +LIE ER+
Sbjct: 996 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1055
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
L AE K +K++ L + QN +L+ Q+ ++++ T SL+ N L
Sbjct: 1056 TLQAE--------KQALKTQ-LKQLETQNNNLQAQILALQRQ-------TVSLQEQNTTL 1099
Query: 862 QTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVR 921
QT+N KLQ+ + LN++ T+ L N+ + L + LE ++E ++
Sbjct: 1100 QTQNAKLQVENST----------LNSQSTS-LMNQNAQLLIQQSSLE-----NENESVIK 1143
Query: 922 FTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPT 981
E K D+L TLKS + + + +
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203
Query: 982 DLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEF 1041
L K QL+ + + L+ E +M + KN E ++ S+L K
Sbjct: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1263
Query: 1042 TNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTE-----EMKN 1096
+ L++ + K +LE + +Y+ L+ ++ L+NQC+ L++ E +N
Sbjct: 1264 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1323
Query: 1097 REAQINKLSADLKNATSLQTTM 1118
R + L+N T L+ M
Sbjct: 1324 RHLLDQIQTLMLQNRTLLEQNM 1345
Score = 80.6 bits (190), Expect = 5e-14
Identities = 186/950 (19%), Positives = 370/950 (38%), Gaps = 83/950 (8%)
Query: 655 ARVEE--DNESLLLQLKKM------ATKARSRKLSPTPPAN-----KL-SIETANDNDEK 700
ARVEE ++ +LL+ K M T+ARS KL N KL +E D D K
Sbjct: 344 ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK 403
Query: 701 ETDEADPAEMKLLLELNEQ--EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ +E M L + + E+ L ++E++ + E + K L +++ +T +
Sbjct: 404 KIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLL 463
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
+SLT K EE ++ D ++ K+++ E++ +RL ++ + + + +
Sbjct: 464 KLEMENQSLT----KTVEE-LRTTVDSVEGNASKILKMEKENQRLSKKVEILENE--IVQ 516
Query: 819 KSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLKNA 874
+ +SL + DL ++ +E+ LR ++ LE +NE L N+ + L+
Sbjct: 517 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQR 573
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK 934
+ ++ + K+ L +KE +K+ ++E + + +K++ + + + L+
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEF--EKRQIKKELEHYKEKGERAEELE 631
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLK-DDAQKSFKPRIPKKPTD----LTTKLQ- 988
++ +++L+ ++++ + R KK D LT +L+
Sbjct: 632 NELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES 691
Query: 989 LKK---MVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNE 1044
L+K +++ E+ +K A + ++ + K LE E ++++ L + F +
Sbjct: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF-KK 750
Query: 1045 KNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
RL+ L N +L+ + K + LE+E +L + +TL + ++ + +L
Sbjct: 751 TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
Query: 1105 SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQV-DNYTKI---DQDKNKLL 1160
K SL+ S + +N KI +++ L
Sbjct: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCKRIE---KQLSTRKDRVTXXXXXXXXXXXQAVVLAN 1217
KE+G + KR K L T ++ + L +
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 1218 THRRLSI---ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDV 1274
++ + L ++ R+ ESK LE+ ++ E KI +LE+ +
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDRYKLLESK---LESTLKKSLEIKEEKIAALEARLEESTN 987
Query: 1275 HIKQLEDALR------QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
+ +QL L+ + + DE + EL K +L
Sbjct: 988 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1047
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
+ E ++ + E LK+ L +LE + +E +T LQ++
Sbjct: 1048 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV----SLQEQNTTLQTQN 1103
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVK---KLE 1445
KL + + + A L + LE + + K +LK Y+ +K KLE
Sbjct: 1104 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE 1163
Query: 1446 HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
+ +EYE L K+ L+ H L VE + + K+ G+++ L+
Sbjct: 1164 LLHERQASEYESLISKHGTLKSAH----KNLEVEHRDLEDRYNQLLKQ----KGQLEDLE 1215
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
+ L E E + ++A+ ++LCG E RLN Q +E
Sbjct: 1216 KMLKVEQEKMLLE-NKNHETVAAEYKKLCG-----ENDRLNHTYSQLLKE 1259
Score = 79.8 bits (188), Expect = 9e-14
Identities = 182/873 (20%), Positives = 349/873 (39%), Gaps = 95/873 (10%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE----LETRPSTEAQTRQIEQLRA 372
+++ +L+Q++ E T D + E + + +++ ++ E L S +++ LR
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALRE 317
Query: 373 KLLAAETLCEEL------MDENEDMKKELRDLXXXXXXMQDN--FREDQADEYSSLRREL 424
K + + L E+ + + E K + +L + + EDQ + + +L
Sbjct: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377
Query: 425 EQTIKNCRVLSFKLK--KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV 482
+ K L KL + ER D+ + E+ E LE+ + + ELEQ +
Sbjct: 378 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ-I 436
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
+R++E++ Q+ L ++ T S +++ K T S E A + +
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 496
Query: 543 QDSLEREADLREQLRNA----EEETANCKQVNPPTFLDKQVMTDNIVTC----------- 587
+ +R + E L N ++ NC+ ++ +K + I T
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556
Query: 588 ---DIHESETVTNSIQNKMIHAASTPSSKEKSDSP-PLSIDKTTEE-TQFHFDLPYLSI- 641
+ H ++TV++ Q I A + EK + SI +T+ + ++ F+ +
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
Query: 642 FNHMA-----ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETAND 696
H A L +E++NE LLQ K K K+ N +E N
Sbjct: 617 LEHYKEKGERAEELENELHHLEKENE--LLQKKITNLKITCEKIEALEQENS-ELERENR 673
Query: 697 NDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTS 756
+K D + LE E+E + L + EL ++ E+LK ++ +++ K
Sbjct: 674 KLKKTLDSFK--NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM-AQLQLENKEL 730
Query: 757 AGSNTTARRSLTTNSNKLAE-ERVKV----LEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
++ L + ER++V L+ E ++K L + ++L +EL +
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL 871
+ +TL K+ ++ + KR L+ +E+E L +T LE D ++L+ ENK+L+
Sbjct: 791 MENQTLQKNL-----EELKISSKR-LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 872 KNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
K D L+ N K LE E K +I + C K +K E K+ T
Sbjct: 845 AEIK----DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-KELVKRATI 899
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD-----LTTK 986
+K+ + L+ + ++ TD L +K
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESK 959
Query: 987 LQ--LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK--------LEKEIDEIR----- 1031
L+ LKK +E E +I + ++ + +++ + K L++ DE R
Sbjct: 960 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1019
Query: 1032 SKLSKNDSEFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALENENSNLS 1084
+S D+++ E E+ K+KD NA L+ +K + K LE +N+NL
Sbjct: 1020 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1079
Query: 1085 NQC-----KTLTEEMKNREAQINKLSADLKNAT 1112
Q +T++ + +N Q ++N+T
Sbjct: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1112
Score = 57.6 bits (133), Expect = 4e-07
Identities = 78/322 (24%), Positives = 140/322 (43%), Gaps = 26/322 (8%)
Query: 261 LVDSNVK--EYQDQIEGLKQEVDILRKRCERV---EKEKSDILLRRLANIDTANKYTTGR 315
L ++NVK + + + L +E+ I ++ C R+ EKE +++ R +I T
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 316 SSEVLKLQQKVNEL--TTHN-EDLRDEKKHLTQKIREIESELETRPSTEAQT--RQIEQL 370
SE LK QQ N+L TH E + K+ L + + + S T + +E
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 371 RAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM---QDNFREDQAD-----EYSSLRR 422
K+ A E EE + N+ +++EL+ + + QD R Q+ E + R
Sbjct: 972 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1031
Query: 423 ELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV 482
E ++T + + +L + ER L+ EK + +L ++ + +Q + I L+++
Sbjct: 1032 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ--ILALQRQT 1089
Query: 483 ARSTEVALRLQRELAE---ANSKFTGSNPSLMKVPQPETVKVSRSSL-TRGGSQEDPAQL 538
E LQ + A+ NS + SLM Q + + +SSL S +
Sbjct: 1090 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN--QNAQLLIQQSSLENENESVIKERED 1147
Query: 539 LRDLQDSLEREADLREQLRNAE 560
L+ L DSL ++ + E L +
Sbjct: 1148 LKSLYDSLIKDHEKLELLHERQ 1169
>AB125644-1|BAF44475.1| 1843|Homo sapiens PKB/Akt-binding protein
protein.
Length = 1843
Score = 97.1 bits (231), Expect = 6e-19
Identities = 177/862 (20%), Positives = 352/862 (40%), Gaps = 82/862 (9%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
QI+ L+QE + L + + + R+ +I+ NK + + K++++
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL---HESIKETSSKLSKIEF 608
Query: 332 HNEDLRDEKKHLTQK---IREIESELE-TRPSTEAQTRQIEQLRA---KLLAAETLCEEL 384
++ E +H +K E+E+EL E ++I L+ K+ A E EL
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
EN +KK L ++ +E+ + +L EL + +++ + S K+ + + +
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVESLKCASMKMAQLQLE 726
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
+LE EK E KK LE++ ++ R++ Q + + RLQ+ L +N K
Sbjct: 727 NKELESEK-EQLKKGLELLKA--SFKKTERLEVSYQGLDIENQ---RLQKTLENSNKKIQ 780
Query: 505 GSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLRNAEEE 562
L + + +T++ + L + + QL ++ SLE+E + L + + E+E
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLE--QLEKE-NKSLEQETSQLEKDKKQLEKE 837
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIH-ESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
+Q D + +N+ ++ E++T++ I I+ S KE
Sbjct: 838 NKRLRQ--QAEIKDTTLEENNVKIGNLEKENKTLSKEIG---IYKESCVRLKELEKENKE 892
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+ + T D+ L + KT ++ D E L +L+K+ + R L
Sbjct: 893 LVKRAT------IDIKTLVTLREDLVSEKLKTQ-QMNNDLEKLTHELEKIGLN-KERLLH 944
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
++ +D+ K + + +K LE+ E++ L ++EE + L+++
Sbjct: 945 DE--------QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE 996
Query: 742 VKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE 801
+K + ++ + + + E + E+ +V+ +LIE ER+
Sbjct: 997 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1056
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
L AE K +K++ L + QN +L+ Q+ ++++ T SL+ N L
Sbjct: 1057 TLQAE--------KQALKTQ-LKQLETQNNNLQAQILALQRQ-------TVSLQEQNTTL 1100
Query: 862 QTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVR 921
QT+N KLQ+ + LN++ T+ L N+ + L + LE ++E ++
Sbjct: 1101 QTQNAKLQVENST----------LNSQSTS-LMNQNAQLLIQQSSLE-----NENESVIK 1144
Query: 922 FTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPT 981
E K D+L TLKS + + + +
Sbjct: 1145 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1204
Query: 982 DLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEF 1041
L K QL+ + + L+ E +M + KN E ++ S+L K
Sbjct: 1205 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1264
Query: 1042 TNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTE-----EMKN 1096
+ L++ + K +LE + +Y+ L+ ++ L+NQC+ L++ E +N
Sbjct: 1265 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1324
Query: 1097 REAQINKLSADLKNATSLQTTM 1118
R + L+N T L+ M
Sbjct: 1325 RHLLDQIQTLMLQNRTLLEQNM 1346
Score = 80.6 bits (190), Expect = 5e-14
Identities = 187/951 (19%), Positives = 371/951 (39%), Gaps = 84/951 (8%)
Query: 655 ARVEE--DNESLLLQLKKM------ATKARSRKLSPTPPAN-----KL-SIETANDNDEK 700
ARVEE ++ +LL+ K M T+ARS KL N KL +E D D K
Sbjct: 344 ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK 403
Query: 701 ETDEADPAEMKLLLELNEQ--EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ +E M L + + E+ L ++E++ + E + K L +++ +T +
Sbjct: 404 KIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLL 463
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
+SLT K EE ++ D ++ K+++ E++ +RL ++ + + + +
Sbjct: 464 KLEMENQSLT----KTVEE-LRTTVDSVEGNASKILKMEKENQRLSKKVEILENE--IVQ 516
Query: 819 KSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLKNA 874
+ +SL + DL ++ +E+ LR ++ LE +NE L N+ + L+
Sbjct: 517 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQR 573
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK 934
+ ++ + K+ L +KE +K+ ++E + + +K++ + + + L+
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEF--EKRQIKKELEHYKEKGERAEELE 631
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLK-DDAQKSFKPRIPKKPTD----LTTKLQ- 988
++ +++L+ ++++ + R KK D LT +L+
Sbjct: 632 NELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES 691
Query: 989 LKK---MVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNE 1044
L+K +++ E+ +K A + ++ + K LE E ++++ L + F +
Sbjct: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF-KK 750
Query: 1045 KNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
RL+ L N +L+ + K + LE+E +L + +TL + ++ + +L
Sbjct: 751 TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
Query: 1105 SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQV-DNYTKI---DQDKNKLL 1160
K SL+ S + +N KI +++ L
Sbjct: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCKRIE---KQLSTRKDRVTXXXXXXXXXXXQAVVLAN 1217
KE+G + KR K L T ++ + L +
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 1218 THRRLSIE----LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKD 1273
++ + L E+ +R+ ESK LE+ ++ E KI +LE+ +
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESK---LESTLKKSLEIKEEKIAALEARLEEST 987
Query: 1274 VHIKQLEDALR------QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK 1327
+ +QL L+ + + DE + EL K +
Sbjct: 988 NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1047
Query: 1328 LEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
L + E ++ + E LK+ L +LE + +E +T LQ++
Sbjct: 1048 LIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV----SLQEQNTTLQTQ 1103
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVK---KL 1444
KL + + + A L + LE + + K +LK Y+ +K KL
Sbjct: 1104 NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1163
Query: 1445 EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTL 1504
E + +EYE L K+ L+ H L VE + + K+ G+++ L
Sbjct: 1164 ELLHERQASEYESLISKHGTLKSAH----KNLEVEHRDLEDRYNQLLKQ----KGQLEDL 1215
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
++ L E E + ++A+ ++LCG E RLN Q +E
Sbjct: 1216 EKMLKVEQEKMLLE-NKNHETVAAEYKKLCG-----ENDRLNHTYSQLLKE 1260
Score = 79.0 bits (186), Expect = 2e-13
Identities = 182/874 (20%), Positives = 349/874 (39%), Gaps = 96/874 (10%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE----LETRPSTEAQTRQIEQLRA 372
+++ +L+Q++ E T D + E + + +++ ++ E L S +++ LR
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALRE 317
Query: 373 KLLAAETLCEEL------MDENEDMKKELRDLXXXXXXMQDN--FREDQADEYSSLRREL 424
K + + L E+ + + E K + +L + + EDQ + + +L
Sbjct: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377
Query: 425 EQTIKNCRVLSFKLK--KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV 482
+ K L KL + ER D+ + E+ E LE+ + + ELEQ +
Sbjct: 378 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ-I 436
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
+R++E++ Q+ L ++ T S +++ K T S E A + +
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 496
Query: 543 QDSLEREADLREQLRNA----EEETANCKQVNPPTFLDKQVMTDNIVTC----------- 587
+ +R + E L N ++ NC+ ++ +K + I T
Sbjct: 497 EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556
Query: 588 ---DIHESETVTNSIQNKMIHAASTPSSKEKSDSP-PLSIDKTTEE-TQFHFDLPYLSI- 641
+ H ++TV++ Q I A + EK + SI +T+ + ++ F+ +
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
Query: 642 FNHMA-----ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETAND 696
H A L +E++NE LLQ K K K+ N +E N
Sbjct: 617 LEHYKEKGERAEELENELHHLEKENE--LLQKKITNLKITCEKIEALEQENS-ELERENR 673
Query: 697 NDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTS 756
+K D + LE E+E + L + EL ++ E+LK ++ +++ K
Sbjct: 674 KLKKTLDSFK--NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM-AQLQLENKEL 730
Query: 757 AGSNTTARRSLTTNSNKLAE-ERVKV----LEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
++ L + ER++V L+ E ++K L + ++L +EL +
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL 871
+ +TL K+ ++ + KR L+ +E+E L +T LE D ++L+ ENK+L+
Sbjct: 791 MENQTLQKNL-----EELKISSKR-LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 872 KNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
K D L+ N K LE E K +I + C K +K E K+ T
Sbjct: 845 AEIK----DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-KELVKRATI 899
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD------LTT 985
+K+ + L+ + ++ TD L +
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLES 959
Query: 986 KLQ--LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK--------LEKEIDEIR---- 1031
KL+ LKK +E E +I + ++ + +++ + K L++ DE R
Sbjct: 960 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1019
Query: 1032 -SKLSKNDSEFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALENENSNL 1083
+S D+++ E E+ K+KD NA L+ +K + K LE +N+NL
Sbjct: 1020 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1079
Query: 1084 SNQC-----KTLTEEMKNREAQINKLSADLKNAT 1112
Q +T++ + +N Q ++N+T
Sbjct: 1080 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1113
Score = 63.3 bits (147), Expect = 9e-09
Identities = 199/1066 (18%), Positives = 408/1066 (38%), Gaps = 89/1066 (8%)
Query: 738 LKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER-VKVLEDEIDEVRKKLIEK 796
L+++++E T ++ + +R N N L++ R ++ DE+D +R+K +
Sbjct: 263 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVR- 321
Query: 797 ERDCERLHAELSLAQKKPKTL--IKSRSLDASDQQNVDLKRQLQVIEQ-EASVLRA-KTQ 852
++L +E+S +++ + K+R + + V L+ + + +Q E + R+ K
Sbjct: 322 ---VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQ 912
LE +N +L+ + +++ ++ + ++ ++ N + + E+L ELE I +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR 438
Query: 913 DEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSF 972
SE ++ E + L S + + T+ S++ +A K
Sbjct: 439 T--SELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDSVEGNASKIL 494
Query: 973 KPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNA-GLSGKEMTAKTKLEKEIDEIR 1031
K + +L K VE LE EI + ++N LS M K +LEK I+ +R
Sbjct: 495 KMEKENQ--------RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR 546
Query: 1032 S------KLSKNDSEFTNE-----KNRLQTEI-AKLKDV---NAKLEGDKDVFANKYKAL 1076
K+ + ++E N+ + R Q A++KD+ N L ++K +
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ---TTMSDCMXXXXXXXXXXX 1133
E E + + + E+ + E N+L K LQ T +
Sbjct: 607 EFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENS 666
Query: 1134 XXXXXXXXXXXQVDNYTKID------QDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRI 1187
+D++ + + +N L E + ++ + +
Sbjct: 667 ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE 726
Query: 1188 EKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITL 1247
K+L + K+++ + L +++ L IE LQ + K L
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE----NQRLQKTLENSNKKIQQL 782
Query: 1248 EAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVE----MVEM 1303
E+E++DL + EN+ +L+ + + K+LE ++ N ++ TS +E +E
Sbjct: 783 ESELQDL--EMENQ--TLQKNLEELKISSKRLEQLEKE--NKSLEQETSQLEKDKKQLEK 836
Query: 1304 RXXXXXXXXXXXXXQDELNNAKI-KLEKTEAESS-------AAKLEMAQLKSDLAKLENX 1355
E NN KI LEK S + + + +L+ + +L
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 1356 XXXXXXXXXXXXXXSSYWENKAKELDTDLQS-----ERKKLDRMRIAHDKDVKNKDAELA 1410
+ K ++++ DL+ E+ L++ R+ HD+ D+
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ-STDDSRYK 955
Query: 1411 TLKGKLK-ILEQNSGAGAKRITELKQEYEETV---KKLEHSLALEKAEYEELTGKYELLE 1466
L+ KL+ L+++ ++I L+ EE+ ++L L K YE L + + E
Sbjct: 956 LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQD--E 1013
Query: 1467 EEHVVTKARLTVEKEQAQGELLHVQKEL---STALGEIKTLQEKLGTESAAWNTEKTEMQ 1523
E V + ++ E + + E +EL L E++ L E A T+ +++
Sbjct: 1014 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1073
Query: 1524 NSIASLQERLCG-GGWEVERARLNARLDQRERELRAANDRRDVLEHH-HDXXXXXXXXXX 1581
+LQ ++ V N L + +L+ N + +
Sbjct: 1074 TQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS 1133
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMN--T 1639
+ E V K + E+ ++ I+ T N
Sbjct: 1134 SLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV 1193
Query: 1640 MRDELKSLHNQVSRFRRERDNYKQMLEAAQ-KSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
+L+ +NQ+ + + + ++ ++ML+ Q K + E KN + A ++ D +
Sbjct: 1194 EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1253
Query: 1699 NKVALLEQQVACLEDELCESRLLASKL-NTELVSEKSSAEVRLAEM 1743
L E +V + + +S L SKL T L +E S + + ++
Sbjct: 1254 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQL 1299
Score = 58.4 bits (135), Expect = 2e-07
Identities = 83/328 (25%), Positives = 150/328 (45%), Gaps = 37/328 (11%)
Query: 261 LVDSNVK--EYQDQIEGLKQEVDILRKRCERV---EKEKSDILLRRLANIDTANKYTTGR 315
L ++NVK + + + L +E+ I ++ C R+ EKE +++ R +I T
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 316 SSEVLKLQQKVNEL--TTH-------NED--LRDEKKHLTQKIREIESELETRPSTEAQT 364
SE LK QQ N+L TH N++ L DE+ + + +ES+LE ST ++
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE---STLKKS 968
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM---QDNFREDQAD-----E 416
+I++ K+ A E EE + N+ +++EL+ + + QD R Q+ E
Sbjct: 969 LEIKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026
Query: 417 YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
+ RE ++T + + +L + ER L+ EK + +L ++ + +Q + I
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ--IL 1084
Query: 477 ELEQEVARSTEVALRLQRELAE---ANSKFTGSNPSLMKVPQPETVKVSRSSL-TRGGSQ 532
L+++ E LQ + A+ NS + SLM Q + + +SSL S
Sbjct: 1085 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN--QNAQLLIQQSSLENENESV 1142
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAE 560
+ L+ L DSL ++ + E L +
Sbjct: 1143 IKEREDLKSLYDSLIKDHEKLELLHERQ 1170
Score = 43.2 bits (97), Expect = 0.010
Identities = 154/868 (17%), Positives = 311/868 (35%), Gaps = 40/868 (4%)
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMI-CQDEKSEKKVRFTEATKKETDTLKSKQX 938
+ DL + T + E E L K L + DE+ E E ++ E D L
Sbjct: 168 ENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE-ERDGLHFLPH 226
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLE 997
+ L DA+ + R+ ++ + T +L K+ +E +E
Sbjct: 227 ASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIR-RLRQELEEKTEQLLDCKQELEQME 285
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSK---LSKNDSEFTNEKNRLQTEIAK 1054
E+ + +N L +A+ + E+D +R K + K +SE + K RL +I
Sbjct: 286 IELKRLQ--QENMNLLSDARSARMYRD-ELDALREKAVRVDKLESEVSRYKERLH-DIEF 341
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSL 1114
K +L+ D V LE++ + L E++ Q+ D++ +
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL-HELEKENLQLKAKLHDMEMERDM 400
Query: 1115 -QTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI-GD 1172
+ + + M +++ ++ + K +G + ++
Sbjct: 401 DRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+ ++L T D V + L+ L E+ EK
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520
Query: 1233 LQ--ARFIKTESKF-ITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
LQ K K LE + L+ + E +I LE ++ H+ Q +LRQ +
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ----ENEHLNQTVSSLRQRSQI 576
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
+ +E + E +IK E + + E +L+++L
Sbjct: 577 SAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE--ELENEL 634
Query: 1350 AKLENXXXXXXXXXXXXXXXSSY---WENKAKELDTDLQSERKKLDRMRI------AHDK 1400
LE E + EL+ + + +K LD + + +K
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK 694
Query: 1401 DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTG 1460
+ D E L+ ++ L+ S A+ E K E E ++L+ L L KA +++ T
Sbjct: 695 ENSQLDEENLELRRNVESLKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKK-TE 752
Query: 1461 KYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT-ESAAWNTEK 1519
+ E+ + + RL E + ++ ++ EL E +TLQ+ L + ++ E+
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 1520 TEMQN-SIASLQERLCGGGWEVERA--RLNARLDQRERELRAANDRRDVLEHHHDXXXXX 1576
E +N S+ +L ++E+ RL + + ++ L N + LE +
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 1577 XXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQ 1636
+ + K + + SEK + ++ + + +
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV-SEKLKTQQMNNDLEKLTHE 931
Query: 1637 MNTMR-DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEE 1695
+ + ++ + LH++ S + LE+ K EIK +A R S+ +
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991
Query: 1696 EYRNKVALLEQQVACLEDELCESRLLAS 1723
+ R ++ +++ L+ E R++ S
Sbjct: 992 QLRQELKTVKKNYEALKQRQDEERMVQS 1019
>X78998-1|CAA55632.1| 1411|Homo sapiens endosomal protein protein.
Length = 1411
Score = 96.3 bits (229), Expect = 1e-18
Identities = 244/1318 (18%), Positives = 515/1318 (39%), Gaps = 102/1318 (7%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKY-------TTGR 315
+SN+ +D + L+QEV L+ + EK S+ L + L + T
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
Query: 316 SSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
S+E+ L+Q++ E T N +++ K QK ++ +E+ S + R + + + +
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 376 AAETLCEELMDEN---EDMKKEL--RDLXXXXXXMQDNFREDQA--DEYSSLR-RELEQT 427
L EEL E +D+K EL R ++ + Q D + R RE E+
Sbjct: 194 T--RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
Query: 428 IKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTE 487
C+ L + +E QL E A+ +++ V + + ++ + EL Q+ TE
Sbjct: 252 KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV--QELQKLKSSVNELTQKNQTLTE 309
Query: 488 VALRLQRE---LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQD 544
L+ +++ L E +++ + S ++ + + + S+ ++ +L +
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE 369
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
E L+E+L E + + K F Q + + + ++ N + +K++
Sbjct: 370 KGEATQKLKEELSEVETKYQHLK----AEFKQLQQQREEKEQHGL-QLQSEINQLHSKLL 424
Query: 605 HAAST--PSSKEKSDSPPLSIDKTTEETQFHFDLPY-LSIFNHMAANNL-RKTAARVEED 660
+ + LS +K ++ Q DL LS + T + + D
Sbjct: 425 ETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD 484
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK-ETDEADPAEMKLLLELNEQ 719
Q ++ ++ + KL + + D D+K + EA + K + L E+
Sbjct: 485 KTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK 544
Query: 720 EATVLRRKVE----------ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
E L K++ +L++ L++QV +LT K+ + +++ + +
Sbjct: 545 EREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE 604
Query: 770 NSNKL--AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD 827
L A++RV LE ++E+ +L E + +L ++ + + +++ +D
Sbjct: 605 QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
QN L ++ + L T L+ KLQ + + L++ +K L L
Sbjct: 665 LQN-HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE- 722
Query: 888 KKTTQLENELKEALAKIKEL----EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+KT +LE ++K+ A E+ E QD + ++++ T+ + T+ K +
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN-TDLELRATELSKQLEMEKEIV 781
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
++ + L ++ + + TK+Q +++ ++ + E+
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841
Query: 1004 Y-VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR-----LQTEIAKLK- 1056
V M+ L + T K KL K D +++ SK++ E N+K + L+ +LK
Sbjct: 842 QKVKMEKEALMTELSTVKDKLSKVSDSLKN--SKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 1057 DVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQI-NKLSADLKNATSLQ 1115
+ ++E K+LE E S+Q K M+ + Q N L + K LQ
Sbjct: 900 QLQVQMENTLKEQKELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
Query: 1116 TTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ-VDNYTKIDQDKNKLLKEVGDKTKKIGDXX 1174
+++ Q + K+ Q + +E+ + +KI
Sbjct: 959 GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 1175 XXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQ 1234
K+++ R+ + L + +LS+ +++D +
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQD----------LKSVEEKLSL---AQEDLIS 1065
Query: 1235 AR-FIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDE 1293
R I ++K I E++ KA E E + + K L+D ++ + + +
Sbjct: 1066 NRNQIGNQNKLI---QELKTAKATLEQDSAKKEQQLQER---CKALQDIQKEKSLKEKEL 1119
Query: 1294 ATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL-AKL 1352
++ E+ +EL + K++ K AK + Q K +L K
Sbjct: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATL 1412
++ + + +EL + + KL + +K + A L
Sbjct: 1180 DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKL 1239
Query: 1413 KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE--EHV 1470
++ L +N G +K+E++ + +++ LEK + ++L G+ +LE ++
Sbjct: 1240 TMQITALNENLGT-------VKKEWQSSQRRVSE---LEK-QTDDLRGEIAVLEATVQNN 1288
Query: 1471 VTKARLTVEK-EQAQGELLHVQK---ELSTALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
+ R +E+ + +GE+ +Q EL L ++LG E+ + + T+ N
Sbjct: 1289 QDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALN 1346
Score = 90.2 bits (214), Expect = 6e-17
Identities = 175/890 (19%), Positives = 359/890 (40%), Gaps = 63/890 (7%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVE----KEKSDILLRRLANIDTANKYTTGRSSEV 319
+ ++E Q+ +E + +++ ++ + +E K K +I L D K G
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIR-EIESELETRPSTEAQTR-QIEQLRA---KL 374
+ +N+L N L+++ LT+K++ + ES + + + Q + Q LRA ++
Sbjct: 562 V-----LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR-V 433
L+ ET EL + + K+++ L + +A + ++ R +L+ + +
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK-TAQRADLQNHLDTAQNA 675
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L K ++ + QL+Q A+ + K Q E+ +KE +++ ++L +
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHC------SQLESHLKEYKEKY-----LSLEQK 724
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA-QLLRDLQDSLEREADL 552
E E K ++ +K + + ++ + E A +L + L+ E +
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
R L+ E + KQ +KQ++ + T + + + + N I T
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFET--LSQETKIQHEELNNRIQTTVTELQ 842
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
K K + L + +T + + L +K A + D E +LK
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL-DLEKTCKELKHQL 901
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-----LELNEQEATVLRRK 727
L K S+E + + E + + +L+ L+ NE+E L+
Sbjct: 902 QVQMENTLKEQKELKK-SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDE 785
+ EL+Q E KKQ++ L ++ ++ LT + +LA +E++ VL++
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQVIEQE 843
++ ++ + + D +EL ++ K++ + SL D + Q ++I++
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ Q ++LQ K LQ ++ KSL+ +K L K ++E E+K +
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK-EKELVNEKSKLAEIE-EIK--CRQ 1136
Query: 904 IKELEMICQDEKSEKKVRFTEAT--KKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
KE+ + ++ KS K E T K L ++ Q L
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLK----KMVEDLECEIG-EMYVVMKNAGLSGKE 1016
K ++ K +K L ++++ K K E+ E ++ ++ + +N G KE
Sbjct: 1197 KDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE 1256
Query: 1017 MTAK----TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANK 1072
+ ++LEK+ D++R +++ ++ N Q E L + K EG+ + K
Sbjct: 1257 WQSSQRRVSELEKQTDDLRGEIAVLEATVQNN----QDERRALLERCLKGEGEIEKLQTK 1312
Query: 1073 YKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCM 1122
L+ + N + + L E N+ QI A L + + +CM
Sbjct: 1313 VLELQRKLDNTTAAVQELGRE--NQSLQIKHTQA-LNRKWAEDNEVQNCM 1359
Score = 86.6 bits (205), Expect = 8e-16
Identities = 208/1063 (19%), Positives = 413/1063 (38%), Gaps = 89/1063 (8%)
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-- 776
Q T++ E E++ E LK + K+L S+ +S S + + R L ++A
Sbjct: 232 QVQTLMDNMTLERERESEKLKDECKKLQSQYAS----SEATISQLRSELAKGPQEVAVYV 287
Query: 777 ERVKVLEDEIDEVRKK-------LIEKERDCERL---HAELSLAQKKPKTLIKSRSLDAS 826
+ ++ L+ ++E+ +K L++KE+D +L H E S+++K + + + LD
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
Query: 827 DQQN--VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAKSLRSDKAL 883
Q+ + L I E S TQ L+ + +++T+ + L+ K + R +K
Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE- 406
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ QL++E+ + +K+ E E + E R E + ++ L K+
Sbjct: 407 ----QHGLQLQSEINQLHSKLLETER----QLGEAHGRLKEQRQLSSEKLMDKEQQVADL 458
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC---EI 1000
L+ K+ + ++ +T +L++ DLE +I
Sbjct: 459 QLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518
Query: 1001 GEMYVVMKNA-GLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
G+ ++N L K + LEKE +++ +K+ + E T N+LQ + L++
Sbjct: 519 GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE-TAVLNQLQEKNHTLQEQV 577
Query: 1060 AKL-EGDKDVFANKYKALENENSNLSNQ---CKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+L E K+ + +A EN + + Q + + + + E +N+L++ L N + +
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL-NESKEK 636
Query: 1116 TTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ--VDNYTKIDQDKNKLLKEVGDKTKKIGDX 1173
+ D Q +D QDK + L ++ T ++
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI---TTQLDQV 693
Query: 1174 XXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL 1233
C ++E L K++ Q L S+E+ + K++
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD----SLEVKASKEQA 749
Query: 1234 QARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDE 1293
+ LE +L E + + ST + LE ++ T K +E
Sbjct: 750 LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT--KQEE 807
Query: 1294 ATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLE 1353
E ++ +ELNN +++ T E K+E L ++L+ ++
Sbjct: 808 -----EKQILKQDFETLSQETKIQHEELNN---RIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 1354 NXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLK 1413
+ K K DL+ K+L H V+ ++ L K
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK-----HQLQVQMENT-LKEQK 913
Query: 1414 GKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK 1473
K LE+ A + EL E+ ++ +++L + E ++L G L++ K
Sbjct: 914 ELKKSLEKEKEASHQLKLELNSMQEQLIQA-QNTLKQNEKEEQQLQGNINELKQSSEQKK 972
Query: 1474 ARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQE-- 1531
++ E QGEL + + +++ + E AA + + +QN+ QE
Sbjct: 973 KQI----EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETF 1028
Query: 1532 -RLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXX----XXXXXXD 1586
+L + E L R D + E + + + D++ + + +
Sbjct: 1029 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088
Query: 1587 YERVSKIQRXXXXXXXXXXXXXXXXXXXIEQ-SEKARKAEITDTKTRYEGQMNTMRDELK 1645
+ K Q+ E +EK++ AEI + K R E ++ + +ELK
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148
Query: 1646 SLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLE 1705
S H S +E N K + + E++ +S+ + E+E RN+ +L+
Sbjct: 1149 S-HKLES--IKEITNLKDAKQLLIQQKLELQG-------KADSLKAAVEQEKRNQ-QILK 1197
Query: 1706 QQVACLEDELCESRL-LASKLNTELVSEKSSAEVRLAEMQSRL 1747
QV E+EL + + +KL++E + EK + E +++L
Sbjct: 1198 DQVKKEEEELKKEFIEKEAKLHSE-IKEKEVGMKKHEENEAKL 1239
Score = 84.6 bits (200), Expect = 3e-15
Identities = 195/1092 (17%), Positives = 402/1092 (36%), Gaps = 67/1092 (6%)
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP-ETVKVSRSSLTRGGS--Q 532
K +E+ + E LQ++ A+ + T S+ L + Q E + ++ + +
Sbjct: 103 KWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFE 162
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEEE--TANCKQVNPPTFLDKQVMTDNIVTCDIH 590
+ AQL ++ D ++ + D LR A E+ T +++N + + + T+ + I
Sbjct: 163 QKAAQLATEIAD-IKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIE 221
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL 650
+ + + + +E+ +S L + ++Q+ +S A
Sbjct: 222 DVAVLKKELVQVQTLMDNMTLERER-ESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 651 RKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
++ A V+E LQ K + ++K + T N L E E++ +E ++
Sbjct: 281 QEVAVYVQE------LQKLKSSVNELTQK-NQTLTENLLKKEQDYTKLEEKHNEESVSKK 333
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSK--ISSVTKTSAGSNTTARRSLT 768
+ L++++ + + L + +L + EL+ K + K T + L
Sbjct: 334 NIQATLHQKDLDCQQLQ-SRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLK 392
Query: 769 TNSNKLAEERVKV------LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
+L ++R + L+ EI+++ KL+E ER H L K + + S
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL-----KEQRQLSSEK 447
Query: 823 LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA 882
L +QQ DL+ +L +E++ + L+ +K + ++++ Q L+ + + + +A
Sbjct: 448 LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 883 L-DLNT------KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
DL K +++N L+ L K KE + + E+ + + +A + ET L
Sbjct: 508 QNDLEQVLRQIGDKDQKIQN-LEALLQKSKENISLLEKEREDLYAKI-QAGEGETAVLNQ 565
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED 995
Q + K +++ + + L L+ V +
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 996 LECEIGEMYVVMKNAGLSGKEMT--------AKT----KLEKEIDEIRSKLSKNDSEFTN 1043
L ++ E + + K T AKT L+ +D ++ L E
Sbjct: 626 LNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNK 685
Query: 1044 EKNRLQTEIAKLKDVN---AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
+L AKL+D ++LE + KY +LE + L Q K L + +A
Sbjct: 686 ITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS 745
Query: 1101 INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLL 1160
+ DL+ L T + + ++ K KL
Sbjct: 746 KEQALQDLQQQRQLNTDLE--LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT 803
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR 1220
K+ +K D + + ++ T + + + +
Sbjct: 804 KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863
Query: 1221 RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE 1280
++S L + K E + K ++ + LE ++LK + +E+T+ + K LE
Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ---VQMENTLKEQKELKKSLE 920
Query: 1281 DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL 1340
+ K + + ++++ + Q +N K E+ + + A +
Sbjct: 921 KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 980
Query: 1341 EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK 1400
E+ +LEN KE + LQ+ +K
Sbjct: 981 ELKIAVLQKTELENKLQQQLTQAAQELAAE-------KEKISVLQNNYEKSQETFKQLQS 1033
Query: 1401 DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTG 1460
D +++EL + LK +E+ + + + + KL L KA E+ +
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ-NKLIQELKTAKATLEQDSA 1092
Query: 1461 KYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE-SAAWNTEK 1519
K E +E + EK + EL++ + +L+ + EIK QEK T+ + + K
Sbjct: 1093 KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA-EIEEIKCRQEKEITKLNEELKSHK 1151
Query: 1520 TEMQNSIASLQE 1531
E I +L++
Sbjct: 1152 LESIKEITNLKD 1163
Score = 83.0 bits (196), Expect = 1e-14
Identities = 242/1298 (18%), Positives = 496/1298 (38%), Gaps = 105/1298 (8%)
Query: 306 DTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR 365
D N G S + + V L +DL+ K E++ ELE + Q
Sbjct: 65 DAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEA 124
Query: 366 QIEQL----RAKLLAAETLCEELMDENEDMK--KELRDLXXXXXXMQDNFREDQADEYSS 419
+ + L A+L + E EE EN ++K K+L + + + + DE S
Sbjct: 125 KPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERS 184
Query: 420 LRRELEQTIK------NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQREN 473
LR EQ + N + KTE ++ A +K+L+++ D M E
Sbjct: 185 LREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLER 244
Query: 474 RIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE 533
E+E + + +LQ + A + + + L K PQ V V + E
Sbjct: 245 -----ERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE 299
Query: 534 DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE 593
+ ++ L++E D + EE+ + K + T K + + + + SE
Sbjct: 300 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA-TLHQKDLDCQQLQS-RLSASE 357
Query: 594 TVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKT 653
T +H S++ + L + + ET++ H+ A +
Sbjct: 358 T--------SLHRIHVELSEKGEATQKLKEELSEVETKYQ----------HLKAEFKQLQ 399
Query: 654 AARVEEDNESLLLQ--LKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK 711
R E++ L LQ + ++ +K + +L + +++ E A+++
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNS 771
L L E++ EL+ + K+Q +E + S T + + L
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG 519
Query: 772 NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
+K +++++ LE + + ++ + E++ E L+A++ + + L + + + + Q+ V
Sbjct: 520 DK--DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
Query: 832 D-----LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN 886
LK Q + +Q L + Q +A Q ++ L L + L S L+ +
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQ--DRVLSLETSVNELNSQ--LNES 633
Query: 887 TKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
+K +QL+ ++K AK EL + + K+ ++ + L+ KQ
Sbjct: 634 KEKVSQLDIQIK---AKT-ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQ-LKKMVEDLECEIGEMYV 1005
Q L+ K +K +K L K + L+ ++ LE + E+
Sbjct: 690 LDQVTAKLQDKQEHCSQLESHL-KEYK----EKYLSLEQKTEELEGQIKKLEADSLEVKA 744
Query: 1006 VMKNAGLS-GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL-- 1062
+ A ++ T LE E+ +L ++ + LQ + L+ + KL
Sbjct: 745 SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK 804
Query: 1063 -EGDKDVFANKYKALENE----NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
E +K + ++ L E + L+N+ +T E++ + + L +L +
Sbjct: 805 QEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK 864
Query: 1118 MSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXX 1177
+SD + +D + K++L ++ + K+ +
Sbjct: 865 VSDSLKNSKSEFEKENQKGKAAI-----LDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
Query: 1178 XXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARF 1237
+++ +L++ ++++ + L L + +SE+ + Q
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL--KQSSEQKKKQIEA 977
Query: 1238 IKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE-------DALRQTTNDK 1290
++ E K L+ +L+ + ++T +AA+ I L+ + +Q +D
Sbjct: 978 LQGELKIAVLQKT--ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
Y + E++ R Q++L + + ++ K A L+ D A
Sbjct: 1036 YGRES---ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELA 1410
K E S K KEL + +S+ +++ ++ +K++ + EL
Sbjct: 1093 KKEQQLQERCKALQDIQKEKSL---KEKELVNE-KSKLAEIEEIKCRQEKEITKLNEELK 1148
Query: 1411 TLKGKLKILEQNSGAGAKRIT-ELKQEYEETVKKLEHSLALEKAEYEELTGKY----ELL 1465
+ K + I E + AK++ + K E + L+ ++ EK + L + E L
Sbjct: 1149 SHKLE-SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL 1207
Query: 1466 EEEHVVTKARLTVE-KEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
++E + +A+L E KE+ G H + E + +I L E LGT W + Q
Sbjct: 1208 KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM-QITALNENLGTVKKEWQSS----QR 1262
Query: 1525 SIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
++ L+++ E+ A L A + + E RA +R
Sbjct: 1263 RVSELEKQTDDLRGEI--AVLEATVQNNQDERRALLER 1298
Score = 53.2 bits (122), Expect = 9e-06
Identities = 113/587 (19%), Positives = 238/587 (40%), Gaps = 55/587 (9%)
Query: 1232 ELQARFIKTESKFITLEAEMRDLKA---DYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
+L++ K + E++ LK+ + K +L + K+ +LE+ + +
Sbjct: 271 QLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESV 330
Query: 1289 DKYD-EAT---SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQ 1344
K + +AT ++ +++ EL+ +K + E S + +
Sbjct: 331 SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQH 390
Query: 1345 LKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN 1404
LK++ +L+ + +K E + L +L R + + +
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMD 450
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
K+ ++A L+ KL LE+ TEL+ + ++T ++ + AL+++ +L
Sbjct: 451 KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKE-LSTALGEIKTLQEKLGT---ESAAWN--TE 1518
LE+ V+ + +K Q LL KE +S E + L K+ E+A N E
Sbjct: 511 LEQ--VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQE 568
Query: 1519 KTE-MQNSIASLQERLCGGGWEVERAR--LNARLDQRERELRAANDRRDVLEHHHDXXXX 1575
K +Q + L E+L ++A+ L+ ++ +++ LRAA DR LE
Sbjct: 569 KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE------TS 622
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
E+VS++ + +E A+ A+ D + +
Sbjct: 623 VNELNSQLNESKEKVSQLD-----------IQIKAKTELLLSAEAAKTAQRADLQNHLDT 671
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEE 1695
N ++D+ ++++ + D L+ Q+ +++++ K + S+ EE
Sbjct: 672 AQNALQDK----QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727
Query: 1696 EYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEK---SSAEVRLAEMQSRLNEYEE 1752
LE Q+ LE + E + + +L ++ + E+R E+ +L E E+
Sbjct: 728 --------LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL-EMEK 778
Query: 1753 ERLLSSGRARVAGLATRMELAWH---KERDEQQRLLQETSTLARDLR 1796
E ++SS R + + +E K+ +E+Q L Q+ TL+++ +
Sbjct: 779 E-IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824
Score = 48.0 bits (109), Expect = 3e-04
Identities = 148/848 (17%), Positives = 329/848 (38%), Gaps = 88/848 (10%)
Query: 981 TDLTTKLQ-LKKMVEDLECE---IGEMYVVM--KNAGLSGKEMTAKTKLEKEIDEIRSKL 1034
TD + +LQ L++ +E+ + E I +M + K A L+ + K+K ++E +R
Sbjct: 131 TDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE-RSLREAA 189
Query: 1035 SKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKAL-------------ENENS 1081
+ + T E N+ T I LK + G +DV K + + E E+
Sbjct: 190 EQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESE 249
Query: 1082 NLSNQCKTLTEEMKNREAQINKLSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXX 1140
L ++CK L + + EA I++L ++L K + + +
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 309
Query: 1141 XXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTX 1200
+ +YTK+++ N+ + V K + C++++ +LS + +
Sbjct: 310 NLLKKEQDYTKLEEKHNE--ESVSKK-----NIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 1201 XXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQARFIKTESKFITLEAEMRDLKAD 1257
L + + L +E +LQ + + E + L++E+ L
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL--- 419
Query: 1258 YENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDE-ATSPVEMVEMRXXXXXXXXXXXX 1316
+K+ E + +K+ + DK + A +++ +
Sbjct: 420 -HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
Query: 1317 XQDELNNAKIKLEKTEA--ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWE 1374
Q +L+ K + ++ +A +S+ AKL AQ +DL ++ +
Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREAQ--NDLEQVLRQIGDK--------------D 522
Query: 1375 NKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK 1434
K + L+ LQ ++ + + +K+ ++ A++ +G+ +L Q ++ L+
Sbjct: 523 QKIQNLEALLQKSKENISLL----EKEREDLYAKIQAGEGETAVLNQLQ----EKNHTLQ 574
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGEL---LHVQ 1491
++ + +KL++ K E L + + ++ H+ + E + EL L+
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQVQE-QKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 1492 KELSTALG-EIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD 1550
KE + L +IK E L + AA ++ ++QN + + Q L E+ ++ +LD
Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN--KITTQLD 691
Query: 1551 QRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYE-RVSKIQRXXXXXXXXXXXXXX 1609
Q +L+ + LE H + E ++ K++
Sbjct: 692 QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE-------ADSLEVKA 744
Query: 1610 XXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQ 1669
++ ++ R+ TD + R + +L+ VS R + + LE+ +
Sbjct: 745 SKEQALQDLQQQRQLN-TDLELR----ATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
Query: 1670 KSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
+ + + + + + ++S + ++ L ++ EL + ++ L TEL
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEE----LNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETS 1789
+ K +++ +E+E+E G+A + L + H+ + + + L+E
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKEN--QKGKAAILDLEKTCKELKHQLQVQMENTLKEQK 913
Query: 1790 TLARDLRQ 1797
L + L +
Sbjct: 914 ELKKSLEK 921
Score = 34.3 bits (75), Expect = 4.5
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 8/111 (7%)
Query: 1634 EGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTD 1693
+G + EL+SL Q+ + E N KQM + ++ A++ + S D
Sbjct: 127 DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIK------SKYD 180
Query: 1694 EEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
EE + A EQ+V L +EL + + L TEL+ +V + + +
Sbjct: 181 EERSLREAA--EQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKE 229
>Z38133-1|CAA86293.1| 1937|Homo sapiens Myosin protein.
Length = 1937
Score = 95.9 bits (228), Expect = 1e-18
Identities = 187/1014 (18%), Positives = 382/1014 (37%), Gaps = 78/1014 (7%)
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
K K L+KS ++++ +K + Q + E + AK + LE L E LQL
Sbjct: 838 KIKPLLKSAE---TEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 894
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+++ D D + ++N++ + AKIKE+ ++E+ E T +K D
Sbjct: 895 QSEA---DSLADAEERCEQLIKNKI-QLEAKIKEVTERAEEEE-EINAELTAKKRKLEDE 949
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KK 991
+ + +K+L ++ I K + + ++
Sbjct: 950 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE-MAGLDETIAKLSKEKKALQETHQQ 1008
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
++DL+ E ++ ++ K AKTKLE+++D++ L + +K R+ E
Sbjct: 1009 TLDDLQAEEDKVNILTK----------AKTKLEQQVDDLEGSLEQE------KKLRMDLE 1052
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
AK KLEGD K + ++ N + L E+++ +E +I+ L + +++
Sbjct: 1053 RAK-----RKLEGD-------LKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDE 1100
Query: 1112 TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIG 1171
+++ + + + + K D ++ L+E+ ++ ++ G
Sbjct: 1101 QAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE---KQRSDLSRELEEISERLEEAG 1157
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
KR + R+D L H EL + D
Sbjct: 1158 GATSAQVELNK--KREAEFQKLRRD----LEEATLQHEAMVAALRKKHADSMAELGEQID 1211
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKY 1291
LQ K E + L+ E DL ++ E I+ + + + + LED + + +
Sbjct: 1212 NLQRVKQKLEKEKSELKMETDDLSSNAE-AISKAKGNL---EKMCRSLEDQVSELKTKEE 1267
Query: 1292 DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK 1351
++ ++ R DE + +L +++ S+ E+ + K
Sbjct: 1268 EQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETK 1327
Query: 1352 LENXXXXXXXXXXXX--XXXSSYWENKA--KELDTDLQSERKKLDRMRIAHDKDVKNKDA 1407
+N Y E + EL L ++ + R ++ D +
Sbjct: 1328 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 1387
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE 1467
EL K KL Q + + + E+T ++L++ + + E L++
Sbjct: 1388 ELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDK 1447
Query: 1468 EHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKLGTESAAWNTEKTE 1521
+ L+ K E+ Q EL QKE LST L ++K + E+ + E
Sbjct: 1448 KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKN 1507
Query: 1522 MQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRDV-LEHHHDXXXXXXXX 1579
+Q I+ L E++ GG ++ E ++ +++Q + E++AA + + LEH
Sbjct: 1508 LQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1567
Query: 1580 XXXXXXDYER-VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMN 1638
+ +R +++ ++ ++R + K + EG +N
Sbjct: 1568 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALR-VKKKMEGDLN 1626
Query: 1639 TMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH------RNSISST 1692
M +L + + R N + +L+ Q + + G + + R ++
Sbjct: 1627 EMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQA 1686
Query: 1693 DEEEYRNKVALLEQQVACLEDELCESRLLASKL---NTELVSEKSSAEVRLAEMQSRLNE 1749
+ EE + E+ E EL ++ L NT L++ K E ++++QS + E
Sbjct: 1687 EIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEE 1746
Query: 1750 YEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLLQETSTLARDLRQTL 1799
+E + +A+ A A M KE+D +R+ + +DL+ L
Sbjct: 1747 VIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1800
Score = 91.5 bits (217), Expect = 3e-17
Identities = 167/868 (19%), Positives = 345/868 (39%), Gaps = 76/868 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L +E++ R + EK++SD L R L I + G +S ++
Sbjct: 1107 LQKKIKELQARIEELGEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQVE 1165
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETR--PSTEAQTRQIEQLRAKLLAAET 379
L +K + LR + + T + + + L + S QI+ L+ E
Sbjct: 1166 LNKKRE---AEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEK 1222
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFK 437
EL E +D+ + ++ R EDQ E + E ++ I + L+ +
Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIND---LTAQ 1279
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRE 495
+ + +A + ++ E + + ++ Q E +LE+E +A LQ
Sbjct: 1280 RARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSS 1339
Query: 496 LAEAN---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD- 551
+ + ++ ++ + + S + R + D Q +L+++ ++ A
Sbjct: 1340 RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1399
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPS 611
L+E + E A C + + + D ++ D+ S ++ K + S
Sbjct: 1400 LQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML--DVERSNAACAALDKKQRNFDKVLS 1457
Query: 612 S-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNESL 664
K+K + ++ + +E++ F Y + + LR+ ++++ L
Sbjct: 1458 EWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL--ETLRRENKNLQQEISDL 1515
Query: 665 LLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATV 723
Q+ + + K+ K I+ A + E + + +++ LELN+ ++ V
Sbjct: 1516 TEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1575
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
RK+ E +++ + LK+ + + S S A R K +E
Sbjct: 1576 -DRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVK------------KKME 1622
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQVIE 841
+++E+ +L RL AE + + ++K L D + DLK QL ++E
Sbjct: 1623 GDLNEMEIQL----NHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVE 1678
Query: 842 QEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
+ A++L+A+ + L A E+ + E + L + + L + +NTKK +LEN+
Sbjct: 1679 RRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK--KLEND 1736
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
+ + ++++E+ ++ + + K T+A + LK +Q
Sbjct: 1737 VSQLQSEVEEVIQESRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNLEQTVKD 1795
Query: 957 XQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
Q L + A K K +I K L+ V +LE GE+ K + K
Sbjct: 1796 LQHRLDEAEQLALKGGKKQIQK----------LEARVRELE---GEVENEQKRNAEAVKG 1842
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKAL 1076
+ + KE+ + KN + ++LQ ++ K + E + +K++ L
Sbjct: 1843 LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKL 1902
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKL 1104
++E + E E+Q+NKL
Sbjct: 1903 QHE-------LEEAEERAHIAESQVNKL 1923
Score = 82.6 bits (195), Expect = 1e-14
Identities = 162/820 (19%), Positives = 337/820 (41%), Gaps = 70/820 (8%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + ++ + +L +E +EL ++ + KE DL
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV--- 894
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG 465
+ +AD + EQ IKN L K+K+ +A++ E+ AE K ++
Sbjct: 895 -----QSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDE 949
Query: 466 PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETV--KVSR 523
++++ I +LE +A+ + + ++ + G + ++ K+ + + + +
Sbjct: 950 CSELKKD--IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQ 1007
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
+L ++ED +L + LE++ DL L ++ + ++ D ++ +
Sbjct: 1008 QTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1067
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIF 642
+ + + ++ + + ++ K ++ S E + + + K +E Q + I
Sbjct: 1068 STMDME-NDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIE 1126
Query: 643 NHMAAN-NLRKTAARVEEDNESLLLQLKKM--ATKAR---SRKLSPTPPANKLSIETAND 696
A+ K + + + E + +L++ AT A+ ++K + +E A
Sbjct: 1127 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATL 1186
Query: 697 NDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTS 756
E + EL EQ L+R ++LE++K LK + +L+S +++K +
Sbjct: 1187 QHEAMVAALRKKHADSMAELGEQ-IDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK-A 1244
Query: 757 AGSNTTARRSLTTNSNKL--AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
G+ RSL ++L EE + L +++ R +L + + R L +K
Sbjct: 1245 KGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSR-----QLDEKDA 1299
Query: 815 KTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD----NEKLQTENKKLQL 870
SRS AS QQ +LK QL+ + + L QS D E+ + E +
Sbjct: 1300 LVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE 1359
Query: 871 LKNAKSLRSDKALDLNTKKTT---QLENELKEALAKIKELEMICQD--EKSEKKVRFTEA 925
L+ A S + + TK T Q EL+EA K+ + ++ E K E
Sbjct: 1360 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEK 1419
Query: 926 TKK----ETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPT 981
TK+ E + L + K ++ Q + K+
Sbjct: 1420 TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS-QKESR 1478
Query: 982 DLTTKL-QLKKMVED--------------LECEIGEMYVVMKNAGLSGKEM-TAKTKLEK 1025
L+T+L ++K + E+ L+ EI ++ + G E+ K ++E+
Sbjct: 1479 SLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ 1538
Query: 1026 EIDEIRSKLSKNDSEFTNEKN---RLQTEIAKLK-DVNAKL-EGDKDV---FANKYKALE 1077
E EI++ L + ++ +E+ R+Q E+ ++K +V+ K+ E D+++ N + +E
Sbjct: 1539 EKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVE 1598
Query: 1078 NENSNLSNQCKTLTEEM---KNREAQINKLSADLKNATSL 1114
S L + ++ + + K E +N++ L +A L
Sbjct: 1599 TMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRL 1638
Score = 64.1 bits (149), Expect = 5e-09
Identities = 160/868 (18%), Positives = 336/868 (38%), Gaps = 74/868 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
++ +D+ LK+++D L +VEKEK L +A +D T K + + +
Sbjct: 944 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQ 1003
Query: 320 LKLQQKVNELTTHNED---LRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 1004 ETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1063
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADE------YSSLRRELEQTIK 429
A+ ++ ++ + + ++L + ++QA E L+ +E+ +
Sbjct: 1064 LAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGE 1123
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELE-QEVARSTEV 488
K E++ L +E E ++L E G N+ +E E Q++ R E
Sbjct: 1124 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEE 1183
Query: 489 A-LRLQRELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL 546
A L+ + +A K S L ++ + VK + + + + L + +
Sbjct: 1184 ATLQHEAMVAALRKKHADSMAELGEQIDNLQRVK-QKLEKEKSELKMETDDLSSNAEAIS 1242
Query: 547 EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET----VTNSIQNK 602
+ + +L + R+ E++ + K T ++Q N +T +T + + K
Sbjct: 1243 KAKGNLEKMCRSLEDQVSELK-----TKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEK 1297
Query: 603 MIHAASTPSSKEKSDSPPLSI-DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ SK+ S + + EET+ L + + + LR+ + EE+
Sbjct: 1298 DALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLRE---QYEEEQ 1354
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
E +L++ +KA S + ET + + T+E + A+ KL L E E
Sbjct: 1355 EG-KAELQRALSKANSEVAQ-----WRTKYET---DAIQRTEELEEAKKKLAQRLQEAEE 1405
Query: 722 TV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERV 779
V + K LE+ K+ L+ +V++L + A + R N +K+ E
Sbjct: 1406 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQR-----NFDKVLSE-- 1458
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
+ + +E + +L +++ L EL + + + L+ ++N +L++++
Sbjct: 1459 --WKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLD--QLETLRRENKNLQQEISD 1514
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
+ ++ + Q E + K Q E +K ++ A ++ +L+ K +++ EL +
Sbjct: 1515 LTEQ--IAEGGKQIHELEKIKKQVEQEKCEI--QAALEEAEASLEHEEGKILRIQLELNQ 1570
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+++ +E + K T + TL ++ +
Sbjct: 1571 VKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEI 1630
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTA 1019
L A +S + + T+L L + E ++ +V + A L
Sbjct: 1631 QLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANL------- 1683
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
L+ EI+E+ + L + + + + E+ + L N K LEN+
Sbjct: 1684 ---LQAEIEELWATLEQTE----RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLEND 1736
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSAD 1107
S L ++ + + +E +N E + K D
Sbjct: 1737 VSQLQSEVEEVIQESRNAEEKAKKAITD 1764
Score = 59.7 bits (138), Expect = 1e-07
Identities = 206/1104 (18%), Positives = 421/1104 (38%), Gaps = 101/1104 (9%)
Query: 531 SQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
++++ A + + Q + + A + + EE+ + L Q D++ +
Sbjct: 848 TEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEER 907
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL 650
+ + N IQ + T ++E+ + ++ + T ++ + + L ++L
Sbjct: 908 CEQLIKNKIQLEAKIKEVTERAEEEEE---INAELTAKKRKLEDECSELK----KDIDDL 960
Query: 651 RKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
T A+VE++ + ++K + + L T + + ++ D+ E
Sbjct: 961 ELTLAKVEKEKHATENKVKNLTEEMAG--LDETIAKLSKEKKALQETHQQTLDDLQAEED 1018
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT- 769
K+ + T + K+E+ D E +Q K+L + + G A+ S
Sbjct: 1019 KVNI------LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM 1072
Query: 770 -NSNKLAEERVKVLEDEIDEVRKKLIEKERDCE-RLHAELSLAQKKPKTL-----IKSRS 822
N + +E+++ E EI + K IE E+ E +L ++ Q + + L + S
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISK-IEDEQAVEIQLQKKIKELQARIEELGEEIEAERAS 1131
Query: 823 LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA 882
+++Q DL R+L+ I + T + N+K + E +KL+ +L+ +
Sbjct: 1132 RAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAM 1191
Query: 883 LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXX 942
+ KK EL E + ++ ++ + EKSE K+ + + K+K
Sbjct: 1192 VAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKM 1251
Query: 943 XXXXXXXXXXXXXXXQATLKSLKD-DAQKS--------FKPRIPKKPTDLTTKLQLKK-- 991
+ + + D AQ++ + ++ +K L ++L K
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDA-LVSQLSRSKQA 1310
Query: 992 ---MVEDLECEIGEMYVVMKNAGLSGKEMT------AKTKLEKEID---EIRSKLSKNDS 1039
+E+L+ ++ E KNA + + + + E+E + E++ LSK +S
Sbjct: 1311 STQQIEELKHQL-EEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS 1369
Query: 1040 EFTNEKNRLQTE----IAKLKDVNAKL-----EGDKDVFA--NKYKALENENSNLSNQCK 1088
E + + +T+ +L++ KL E ++ V A K +LE L N+ +
Sbjct: 1370 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVE 1429
Query: 1089 TLTEEMKNREAQINKLSADLKNATSL--------QTTMSDCMXXXXXXXXXXXXXXXXXX 1140
L +++ A L +N + + T ++
Sbjct: 1430 DLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKN 1489
Query: 1141 XXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEK-----QLSTRK 1195
+D + ++ L +E+ D T++I + K++E+ Q + +
Sbjct: 1490 VYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEE 1549
Query: 1196 DRVTXXXXXXXXXXXQA---VVLANTHRRLSIELTSEKDELQARFIK-TESKFITLEAEM 1251
+ Q V + R+++ E E D+L+ + E+ TL+AE+
Sbjct: 1550 AEASLEHEEGKILRIQLELNQVKSEVDRKIA-EKDEEIDQLKRNHTRVVETMQSTLDAEI 1608
Query: 1252 RDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXX 1311
R + D +E + ++ + ++ + Y ++ ++
Sbjct: 1609 RS-RNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRN-YRNTQGILKETQLHLDDALRG 1666
Query: 1312 XXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSS 1371
Q + + L + E E A LE + +A+ E S
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1726
Query: 1372 YWENKAKELD-TDLQSE-RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
K E D + LQSE + + R A +K K + A + +LK EQ++ A +R
Sbjct: 1727 INTKKKLENDVSQLQSEVEEVIQESRNAEEK-AKKAITDAAMMAEELK-KEQDTSAHLER 1784
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELT-GKYELLEEEHVVTKARLTVEKEQAQGELL 1488
+K+ E+TVK L+H L++AE L GK ++ + E V + VE EQ +
Sbjct: 1785 ---MKKNLEQTVKDLQH--RLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRN--A 1837
Query: 1489 HVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA--RLN 1546
K L +K L + TE N +Q+ + LQ ++ + E A + N
Sbjct: 1838 EAVKGLRKHERRVKELTYQ--TEEDRKNV--LRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1893
Query: 1547 ARLD---QRERELRAANDRRDVLE 1567
A L + + EL A +R + E
Sbjct: 1894 ANLSKFRKLQHELEEAEERAHIAE 1917
>X15696-1|CAA33731.1| 1085|Homo sapiens protein ( Human muscle mRNA
for embryonic myosin heavy chain (SMHCE). ).
Length = 1085
Score = 95.9 bits (228), Expect = 1e-18
Identities = 175/912 (19%), Positives = 363/912 (39%), Gaps = 75/912 (8%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEEL-------EQDKEALKKQVKELTSKIS 750
+ E +E AE+ E E + L++ +++L E++K A + +VK LT ++S
Sbjct: 70 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELS 129
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ +T A T + +++ A + ++ ED+++ + K + E+ E L + L
Sbjct: 130 GLDETIA--KLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE 187
Query: 811 QKKPKTLIKSR-----SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
+K L +++ L + + +DL+ Q +++ + L++ E QT
Sbjct: 188 KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 247
Query: 866 KKLQ-LLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTE 924
+ Q +K ++ + ++ ++ T+ + E K+ +ELE E SE+
Sbjct: 248 LQFQKKIKELQARIEELEEEIEAERATRAKTE-KQRSDYARELE-----ELSERLEEAGG 301
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
T + + K ++ ATL+ D+ +I
Sbjct: 302 VTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQ---R 358
Query: 985 TKLQLKKMVEDLECEIGEMYVVMKNAGLS--GKEMTAKTKLEKEIDEIRSK---LSKNDS 1039
K +L+K + + EI ++ M++ S E +T LE ++ E R K + ++ S
Sbjct: 359 VKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT-LEDQLSEARGKNEEIQRSLS 417
Query: 1040 EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
E T +K+RLQTE +L + +LE + + + L + Q TEE+K +
Sbjct: 418 ELTTQKSRLQTEAGEL---SRQLEEKESIVSQ----LSRSKQAFTQQ----TEELKRQLE 466
Query: 1100 QINKLSADLKNATSLQTTMSDC---MXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQD 1155
+ NK L +A LQ++ DC +V + TK + D
Sbjct: 467 EENKAKNALAHA--LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 524
Query: 1156 KNKLLKEVGDKTKKIG----DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQ 1211
+ +E+ + KK+ D C +EK + V
Sbjct: 525 AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 584
Query: 1212 AVVLANTHR---RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLEST 1268
A L R ++ E ++ +E QA + + +L E+ LK YE + LE T
Sbjct: 585 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLE-T 643
Query: 1269 IAAKDVHIKQ-LEDALRQ-----TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELN 1322
+ ++ +++Q + D Q T + +++ +E+ + +E
Sbjct: 644 VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 703
Query: 1323 NAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDT 1382
+I+LE T+ +S + ++A+ ++ +L+ N+A L
Sbjct: 704 ILRIQLELTQVKSEIDR-KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKK 762
Query: 1383 DLQSERKKLDRMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
++ + +++ ++++H ++ L +++G+LK + + + +LK E +
Sbjct: 763 KMEGDLNEIE-IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLK----EQL 817
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ------GELLHVQKELS 1495
+E L +AE EEL E E + + L E+ Q L+H +K+L
Sbjct: 818 AIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLE 877
Query: 1496 TALGEIKTLQEKLGTESA-AWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
T L ++++ E ++ A K + ++ +E R+ L+Q +
Sbjct: 878 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 937
Query: 1555 ELRAANDRRDVL 1566
+L+ D + L
Sbjct: 938 DLQHRLDEAEQL 949
Score = 83.4 bits (197), Expect = 7e-15
Identities = 218/1038 (21%), Positives = 396/1038 (38%), Gaps = 96/1038 (9%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
EL+ ++ K K L L Q+ DL QLQV + ++L A+ + + K Q E
Sbjct: 8 ELAKSEAKRKEL--EEKLVTLVQEKNDL--QLQVQAESENLLDAEERCDQLIKAKFQLEA 63
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTE- 924
K ++ + A+ A +L KK +LE+E E I +LE+ K EK+ TE
Sbjct: 64 KIKEVTERAEDEEEINA-ELTAKKR-KLEDECSELKKDIDDLELTLA--KVEKEKHATEN 119
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD--DAQKSFKPRIPKKPTD 982
K T+ L L++ +D ++ K ++ ++ D
Sbjct: 120 KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVED 179
Query: 983 LTTKL-QLKKMVEDLECEIGEMYVVMKNA-----GLSGKEMTAKTKLEK---EIDEIRSK 1033
L + L Q KK+ DLE ++ +K A L + +L+K E +++SK
Sbjct: 180 LESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSK 239
Query: 1034 LSKNDS---EFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALENENSNL 1083
+ + +F + LQ I +L++ AK E + +A + + L
Sbjct: 240 VEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEA 299
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
T E K REA+ KL DL+ AT M +
Sbjct: 300 GGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRV 359
Query: 1144 XQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXX 1203
Q K++++K++ E+ D + + C+ +E QLS + +
Sbjct: 360 KQ-----KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 414
Query: 1204 XXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKIT 1263
Q L LS +L EK+ + ++ +++ F T + E + + ENK
Sbjct: 415 SLSELTTQKSRLQTEAGELSRQL-EEKESIVSQLSRSKQAF-TQQTEELKRQLEEENKAK 472
Query: 1264 -----SLESTIAAKDVHIKQLED----------ALRQTTND------KYD-EATSPVEMV 1301
+L+S+ D+ +Q E+ AL + ++ KY+ +A E +
Sbjct: 473 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 532
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAK-IKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
E Q E NAK LEKT+ E+ L D+ + +
Sbjct: 533 EEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG---EVEDLMVDVERANSLAAALD 589
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN--KDA--ELATLKGKL 1416
+ W+ K +E +L++ K+ + K +KN ++A +L T+K +
Sbjct: 590 KKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK-LKNAYEEALDQLETVKREN 648
Query: 1417 KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL 1476
K LEQ ++I E + E ++K + LEKA+ + + E E R+
Sbjct: 649 KNLEQEIADLTEQIAENGKTIHE-LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI 707
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAWNTEKTEMQNSIASLQERLCG 1535
+E Q + E+ E + ++K Q + T +A + E +N L++++ G
Sbjct: 708 QLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE-VRSRNEAIRLKKKMEG 766
Query: 1536 --GGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKI 1593
E++ + N + + + LR+ + + H D ER + +
Sbjct: 767 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL 826
Query: 1594 QRXXXXXXXXXXXXXXXXXXXIEQSEKARK---AEITDTKTRYE---GQMNTMRDELKSL 1647
+ +EQ+E+ARK E+ D+ R + Q ++ K L
Sbjct: 827 LQ----------AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL 876
Query: 1648 HNQVSRFRRE-RDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQ 1706
+ + + E D + A +K+ I + A + ++ E K LEQ
Sbjct: 877 ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK--NLEQ 934
Query: 1707 QVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGL 1766
V L+ L E+ LA K + + + E R+ E++ L E E+++ S +
Sbjct: 935 TVKDLQHRLDEAEQLALKGGKKQIQK---LETRIRELEFEL-EGEQKKNTESVKGLRKYE 990
Query: 1767 ATRMELAWHKERDEQQRL 1784
EL + E D + L
Sbjct: 991 RRVKELTYQSEEDRKNVL 1008
Score = 72.1 bits (169), Expect = 2e-11
Identities = 193/930 (20%), Positives = 367/930 (39%), Gaps = 105/930 (11%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRS 316
S +++ + +E ++ LR ER +++ + D+ L + + +D N + +
Sbjct: 171 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 230
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQ----TRQIE 368
E +LQ KV + T + + K L +I E+E E+E TR TE Q R++E
Sbjct: 231 FEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 290
Query: 369 QLRAKLLAAETLCEELMDENE-------DMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
+L +L A + ++ N+ ++++L + M R+ AD + L
Sbjct: 291 ELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELG 350
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQL--EQEKAEHEKKLLE-IVGGPDGMQRENRIK-- 476
+++ + + L + + + + D L E K LE I + E R K
Sbjct: 351 EQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNE 410
Query: 477 ELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS-SLTRGGSQEDP 535
E+++ ++ T RLQ E E + + + ++ + + ++ L R +E+
Sbjct: 411 EIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENK 470
Query: 536 AQ--LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE 593
A+ L LQ S LREQ +E A ++ + T I +E
Sbjct: 471 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 530
Query: 594 TVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSI--FNHMAA---- 647
+ + + + E ++ S++KT + Q + + + N +AA
Sbjct: 531 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 590
Query: 648 --NNLRKTAA----RVEEDNESLLLQLKKMATKARSR-KLSPTPPANKLSIETA-NDNDE 699
N K A + EE L LK+ + + KL +ET +N
Sbjct: 591 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 650
Query: 700 KETDEADPAEM-----KLLLELN------EQEATVLRRKVEE----LEQDKEALKKQVKE 744
E + AD E K + EL E E ++ +EE LE ++ + + E
Sbjct: 651 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 710
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI---DEVRKKLIEKERDCE 801
LT S + + A + + L N + E L+ E+ +E + + E D
Sbjct: 711 LTQVKSEIDRKIAEKDEEIEQ-LKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 769
Query: 802 RLHAELSLAQKK-PKTLIKSRS-----------LDASDQQNVDLKRQLQVIEQEASVLRA 849
+ +LS A ++ +TL RS LD + + DLK QL ++E+ A++L+A
Sbjct: 770 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 829
Query: 850 KTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
+ + L A E+ + E + L + + L + ++TKK +LE +L + +++
Sbjct: 830 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK--KLETDLMQLQSEV 887
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
++ ++ + + K T+A + LK +Q Q L
Sbjct: 888 EDASRDARNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 946
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEI-GEMYVVMKNAGLSGKEMTAKTKL 1023
+ A K K +I K L+ + +LE E+ GE KN S K + +
Sbjct: 947 EQLALKGGKKQIQK----------LETRIRELEFELEGEQ---KKNTE-SVKGLRKYERR 992
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
KE+ + KN + ++LQ ++ K + + + K++ ++E
Sbjct: 993 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHE---- 1048
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+ E E+Q+NKL A ++ TS
Sbjct: 1049 ---LEEAEERADIAESQVNKLRAKTRDFTS 1075
Score = 68.9 bits (161), Expect = 2e-10
Identities = 166/870 (19%), Positives = 356/870 (40%), Gaps = 67/870 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ +D+ LK+++D L +VEKEK T NK + E+ L + +
Sbjct: 87 RKLEDECSELKKDIDDLELTLAKVEKEKH----------ATENK-VKNLTEELSGLDETI 135
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAETLCEELM 385
+LT + L++ + ++ E ++ + T+++ +Q+E L + L E+
Sbjct: 136 AKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-------EQEK 188
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
D+++ R L Q++ + + D+ R ++ + C++ S K++ +
Sbjct: 189 KLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQS-KVEDEQTLG 247
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
Q +++ E + ++ E+ + +R R K +Q + E+ L L EA T
Sbjct: 248 LQFQKKIKELQARIEELEEEIEA-ERATRAKTEKQRSDYARELE-ELSERLEEAGG-VTS 304
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ L K + E +K+ R E LR + + A+L EQ+ N +
Sbjct: 305 TQIELNKKREAEFLKLRRDLEEATLQHEAMVATLR--KKHADSVAELGEQIDNLQRVKQK 362
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHES--ETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
++ L+ ++ ++ + ++ E + ++++++ A ++S S L+
Sbjct: 363 LEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLS-ELTT 421
Query: 624 DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPT 683
K+ +T+ +L + L ++ + E L QL++ KA++ L+
Sbjct: 422 QKSRLQTEAG-ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE-ENKAKN-ALAHA 478
Query: 684 PPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRK--------VEELEQDK 735
+++ + + E+E + AE++ L E R K EELE+ K
Sbjct: 479 LQSSRHDCDLLREQYEEE--QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 536
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVKVLEDEIDEVR---- 790
+ L +++++ ++ +V A T +R + + + ER L +D+ +
Sbjct: 537 KKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 596
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTL------IKSRSLDASDQQNVDLKRQLQVIEQEA 844
K L E + CE AEL + K+ ++L +K+ +A DQ +KR+ + +EQE
Sbjct: 597 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET-VKRENKNLEQEI 655
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSL---RSDKALDLNTKKTTQLENELKEAL 901
+ L + +L+ K+++L K L ++ AL+ K +++ EL +
Sbjct: 656 ADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 715
Query: 902 AKIKELEMICQDEKSEK-KVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
++I + ++ +DE+ E+ K + + L ++ +
Sbjct: 716 SEI-DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQ 774
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L A ++ K + T+L L + E ++ +V + A L E+ +
Sbjct: 775 LSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV-EE 833
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEK-NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
+ E E KL++ + +NE+ L T+ L KLE D L++E
Sbjct: 834 LRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETD-------LMQLQSE 886
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+ S + E+ K ++ +LK
Sbjct: 887 VEDASRDARNAEEKAKKAITDAAMMAEELK 916
Score = 37.9 bits (84), Expect = 0.37
Identities = 53/311 (17%), Positives = 134/311 (43%), Gaps = 24/311 (7%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ + + +QI + + L K +++E EK+DI L ++ A +++L+
Sbjct: 651 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA----LEEAEAALEHEEAKILR 706
Query: 322 LQQKVNELTTH-NEDLRDEKKHLTQKIREIESELETRPST-EAQTR-QIEQLRAKLLAAE 378
+Q ++ ++ + + + ++ + + Q R + +ET S +A+ R + E +R K
Sbjct: 707 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEG 766
Query: 379 TLCE---ELMDENEDMKKELRDLXXXXXXMQDN--FREDQADEYSSLRRELEQTIKNCRV 433
L E +L N + L+ L ++D +D L+ +L + +
Sbjct: 767 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL 826
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L ++++ +Q E+ + E++LL+ R++ L + +L+
Sbjct: 827 LQAEVEELRATLEQTERARKLAEQELLD---------SNERVQLLHTQNTSLIHTKKKLE 877
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG--GSQEDPAQLLRDLQDSLEREA- 550
+L + S+ ++ + ++ +++ ++D + L ++ +LE+
Sbjct: 878 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 937
Query: 551 DLREQLRNAEE 561
DL+ +L AE+
Sbjct: 938 DLQHRLDEAEQ 948
>X51593-1|CAA35942.1| 1085|Homo sapiens embryonic myosin heavy chain
(1085 AA) protein.
Length = 1085
Score = 95.1 bits (226), Expect = 2e-18
Identities = 175/912 (19%), Positives = 363/912 (39%), Gaps = 75/912 (8%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEEL-------EQDKEALKKQVKELTSKIS 750
+ E +E AE+ E E + L++ +++L E++K A + +VK LT ++S
Sbjct: 70 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELS 129
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ +T A T + +++ A + ++ ED+++ + K + E+ E L + L
Sbjct: 130 GLDETIA--KLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE 187
Query: 811 QKKPKTLIKSR-----SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
+K L +++ L + + +DL+ Q +++ + L++ E QT
Sbjct: 188 KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 247
Query: 866 KKLQ-LLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTE 924
+ Q +K ++ + ++ ++ T+ + E K+ +ELE E SE+
Sbjct: 248 LQFQKKIKELQARIEELEEEIEAERATRAKTE-KQRSDYARELE-----ELSERLEEAGG 301
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
T + + K ++ ATL+ D+ +I
Sbjct: 302 VTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQ---R 358
Query: 985 TKLQLKKMVEDLECEIGEMYVVMKNAGLS--GKEMTAKTKLEKEIDEIRSK---LSKNDS 1039
K +L+K + + EI ++ M++ S E +T LE ++ E R K + ++ S
Sbjct: 359 VKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT-LEDQLSEARGKNEEIQRSLS 417
Query: 1040 EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
E T +K+RLQTE +L + +LE + + + L + Q TEE+K +
Sbjct: 418 ELTTQKSRLQTEAGEL---SRQLEEKESIVSQ----LSRSKQAFTQQ----TEELKRQLE 466
Query: 1100 QINKLSADLKNATSLQTTMSDC---MXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQD 1155
+ NK L +A LQ++ DC +V + TK + D
Sbjct: 467 EENKAKNALGHA--LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 524
Query: 1156 KNKLLKEVGDKTKKIG----DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQ 1211
+ +E+ + KK+ D C +EK + V
Sbjct: 525 AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 584
Query: 1212 AVVLANTHR---RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLEST 1268
A L R ++ E ++ +E QA + + +L E+ LK YE + LE T
Sbjct: 585 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLE-T 643
Query: 1269 IAAKDVHIKQ-LEDALRQ-----TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELN 1322
+ ++ +++Q + D Q T + +++ +E+ + +E
Sbjct: 644 VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 703
Query: 1323 NAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDT 1382
+I+LE T+ +S + ++A+ ++ +L+ N+A L
Sbjct: 704 ILRIQLELTQVKSEIDR-KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKK 762
Query: 1383 DLQSERKKLDRMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
++ + +++ ++++H ++ L +++G+LK + + + +LK E +
Sbjct: 763 KMEGDLNEIE-IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLK----EQL 817
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ------GELLHVQKELS 1495
+E L +AE EEL E E + + L E+ Q L+H +K+L
Sbjct: 818 AIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLE 877
Query: 1496 TALGEIKTLQEKLGTESA-AWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
T L ++++ E ++ A K + ++ +E R+ L+Q +
Sbjct: 878 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 937
Query: 1555 ELRAANDRRDVL 1566
+L+ D + L
Sbjct: 938 DLQHRLDEAEQL 949
Score = 82.6 bits (195), Expect = 1e-14
Identities = 218/1038 (21%), Positives = 395/1038 (38%), Gaps = 96/1038 (9%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
EL+ ++ K K L L Q+ DL QLQV + ++L A+ + + K Q E
Sbjct: 8 ELAKSEAKRKEL--EEKLVTLVQEKNDL--QLQVQAESENLLDAEERCDQLIKAKFQLEA 63
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTE- 924
K ++ + A+ A +L KK +LE+E E I +LE+ K EK+ TE
Sbjct: 64 KIKEVTERAEDEEEINA-ELTAKKR-KLEDECSELKKDIDDLELTLA--KVEKEKHATEN 119
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD--DAQKSFKPRIPKKPTD 982
K T+ L L++ +D ++ K ++ ++ D
Sbjct: 120 KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVED 179
Query: 983 LTTKL-QLKKMVEDLECEIGEMYVVMKNA-----GLSGKEMTAKTKLEK---EIDEIRSK 1033
L + L Q KK+ DLE ++ +K A L + +L+K E +++SK
Sbjct: 180 LESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSK 239
Query: 1034 LSKNDS---EFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALENENSNL 1083
+ + +F + LQ I +L++ AK E + +A + + L
Sbjct: 240 VEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEA 299
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
T E K REA+ KL DL+ AT M +
Sbjct: 300 GGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRV 359
Query: 1144 XQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXX 1203
Q K++++K++ E+ D + + C+ +E QLS + +
Sbjct: 360 KQ-----KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 414
Query: 1204 XXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKIT 1263
Q L LS +L EK+ + ++ +++ F T + E + + ENK
Sbjct: 415 SLSELTTQKSRLQTEAGELSRQL-EEKESIVSQLSRSKQAF-TQQTEELKRQLEEENKAK 472
Query: 1264 -----SLESTIAAKDVHIKQLED----------ALRQTTND------KYD-EATSPVEMV 1301
+L+S+ D+ +Q E+ AL + ++ KY+ +A E +
Sbjct: 473 NALGHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 532
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAK-IKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
E Q E NAK LEKT+ E+ L D+ + +
Sbjct: 533 EEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG---EVEDLMVDVERANSLAAALD 589
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN--KDA--ELATLKGKL 1416
+ W+ K +E +L++ K+ + K +KN ++A +L T+K +
Sbjct: 590 KKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK-LKNAYEEALDQLETVKREN 648
Query: 1417 KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL 1476
K LEQ ++I E + E ++K + LEKA+ + + E E R+
Sbjct: 649 KNLEQEIADLTEQIAENGKTIHE-LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI 707
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAWNTEKTEMQNSIASLQERLCG 1535
+E Q + E+ E + ++K Q + T +A + E N L++++ G
Sbjct: 708 QLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE-VRRANEAIRLKKKMEG 766
Query: 1536 --GGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKI 1593
E++ + N + + + LR+ + + H D ER + +
Sbjct: 767 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL 826
Query: 1594 QRXXXXXXXXXXXXXXXXXXXIEQSEKARK---AEITDTKTRYE---GQMNTMRDELKSL 1647
+ +EQ+E+ARK E+ D+ R + Q ++ K L
Sbjct: 827 LQ----------AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL 876
Query: 1648 HNQVSRFRRE-RDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQ 1706
+ + + E D + A +K+ I + A + ++ E K LEQ
Sbjct: 877 ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK--NLEQ 934
Query: 1707 QVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGL 1766
V L+ L E+ LA K + + + E R+ E++ L E E+++ S +
Sbjct: 935 TVKDLQHRLDEAEQLALKGGKKQIQK---LETRIRELEFEL-EGEQKKNTESVKGLRKYE 990
Query: 1767 ATRMELAWHKERDEQQRL 1784
EL + E D + L
Sbjct: 991 RRVKELTYQSEEDRKNVL 1008
Score = 79.4 bits (187), Expect = 1e-13
Identities = 150/842 (17%), Positives = 299/842 (35%), Gaps = 42/842 (4%)
Query: 985 TKLQLKKMVEDLE-CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
T+ ++K + E+L + + + L A L+ E D++ S L+K S+
Sbjct: 117 TENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNS-LNKTKSKLEQ 175
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
+ L++ + + K + LE +K K + +L N + L E +K ++ + +
Sbjct: 176 QVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQ 235
Query: 1104 LSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEV 1163
L + +++ +L + + + K D + L+E+
Sbjct: 236 LQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE---KQRSDYARELEEL 292
Query: 1164 GDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS 1223
++ ++ G KR + L R+D L H
Sbjct: 293 SERLEEAGGVTSTQIELNK--KREAEFLKLRRD----LEEATLQHEAMVATLRKKHADSV 346
Query: 1224 IELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDAL 1283
EL + D LQ K E + + E+ DL + E S+ + A + + LED L
Sbjct: 347 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME----SVSKSKANLEKICRTLEDQL 402
Query: 1284 RQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMA 1343
+ + S E+ + +E + +L +++ + E+
Sbjct: 403 SEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK 462
Query: 1344 QLKSDLAKLENXXXXXXXXXXXX--XXXSSYWENKA--KELDTDLQSERKKLDRMRIAHD 1399
+ + K +N Y E + EL L ++ + R ++
Sbjct: 463 RQLEEENKAKNALGHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE 522
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
D + EL K KL Q+S + + E+T ++L+ + + E
Sbjct: 523 TDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN 582
Query: 1460 GKYELLEEEH-----VVTKARLTVEKEQAQGEL-LHVQKELSTALGEIKTLQEKLGTESA 1513
L+++ V+ + + E+ QA+ E L + LST L ++K E+ +
Sbjct: 583 SLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLE 642
Query: 1514 AWNTEKTEMQNSIASLQERLCGGG---WEVERARLNARLDQRERELRAANDRRDVLEHHH 1570
E ++ IA L E++ G E+E++R L++ + +L A + LEH
Sbjct: 643 TVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL-ALEEAEAALEHEE 701
Query: 1571 DXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTK 1630
+ +R + +E R E K
Sbjct: 702 AKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLK 761
Query: 1631 TRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH----- 1685
+ EG +N + +L + Q + + + + L+ Q + + G + +
Sbjct: 762 KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 821
Query: 1686 -RNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKL---NTELVSEKSSAEVRLA 1741
R ++ + EE R + E+ E EL +S L NT L+ K E L
Sbjct: 822 RRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLM 881
Query: 1742 EMQSRLNEYEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLLQETSTLARDLRQ 1797
++QS + + + + +A+ A A M KE+D +R+ + +DL+
Sbjct: 882 QLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 941
Query: 1798 TL 1799
L
Sbjct: 942 RL 943
Score = 71.7 bits (168), Expect = 2e-11
Identities = 192/930 (20%), Positives = 366/930 (39%), Gaps = 105/930 (11%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRS 316
S +++ + +E ++ LR ER +++ + D+ L + + +D N + +
Sbjct: 171 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 230
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQ----TRQIE 368
E +LQ KV + T + + K L +I E+E E+E TR TE Q R++E
Sbjct: 231 FEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 290
Query: 369 QLRAKLLAAETLCEELMDENE-------DMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
+L +L A + ++ N+ ++++L + M R+ AD + L
Sbjct: 291 ELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELG 350
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQL--EQEKAEHEKKLLE-IVGGPDGMQRENRIK-- 476
+++ + + L + + + + D L E K LE I + E R K
Sbjct: 351 EQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNE 410
Query: 477 ELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS-SLTRGGSQEDP 535
E+++ ++ T RLQ E E + + + ++ + + ++ L R +E+
Sbjct: 411 EIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENK 470
Query: 536 AQ-LLRDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE 593
A+ L S + D LREQ +E A ++ + T I +E
Sbjct: 471 AKNALGHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 530
Query: 594 TVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSI--FNHMAA---- 647
+ + + + E ++ S++KT + Q + + + N +AA
Sbjct: 531 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 590
Query: 648 --NNLRKTAA----RVEEDNESLLLQLKKMATKARSR-KLSPTPPANKLSIETA-NDNDE 699
N K A + EE L LK+ + + KL +ET +N
Sbjct: 591 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 650
Query: 700 KETDEADPAEM-----KLLLELN------EQEATVLRRKVEE----LEQDKEALKKQVKE 744
E + AD E K + EL E E ++ +EE LE ++ + + E
Sbjct: 651 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 710
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEK---ERDCE 801
LT S + + A + + L N + E L+ E+ + + K E D
Sbjct: 711 LTQVKSEIDRKIAEKDEEIEQ-LKRNYQRTVETMQSALDAEVRRANEAIRLKKKMEGDLN 769
Query: 802 RLHAELSLAQKK-PKTLIKSRS-----------LDASDQQNVDLKRQLQVIEQEASVLRA 849
+ +LS A ++ +TL RS LD + + DLK QL ++E+ A++L+A
Sbjct: 770 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 829
Query: 850 KTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
+ + L A E+ + E + L + + L + ++TKK +LE +L + +++
Sbjct: 830 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK--KLETDLMQLQSEV 887
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
++ ++ + + K T+A + LK +Q Q L
Sbjct: 888 EDASRDARNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 946
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEI-GEMYVVMKNAGLSGKEMTAKTKL 1023
+ A K K +I K L+ + +LE E+ GE KN S K + +
Sbjct: 947 EQLALKGGKKQIQK----------LETRIRELEFELEGEQ---KKNTE-SVKGLRKYERR 992
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
KE+ + KN + ++LQ ++ K + + + K++ ++E
Sbjct: 993 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHE---- 1048
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+ E E+Q+NKL A ++ TS
Sbjct: 1049 ---LEEAEERADIAESQVNKLRAKTRDFTS 1075
Score = 68.5 bits (160), Expect = 2e-10
Identities = 166/870 (19%), Positives = 355/870 (40%), Gaps = 67/870 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ +D+ LK+++D L +VEKEK T NK + E+ L + +
Sbjct: 87 RKLEDECSELKKDIDDLELTLAKVEKEKH----------ATENK-VKNLTEELSGLDETI 135
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAETLCEELM 385
+LT + L++ + ++ E ++ + T+++ +Q+E L + L E+
Sbjct: 136 AKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-------EQEK 188
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
D+++ R L Q++ + + D+ R ++ + C++ S K++ +
Sbjct: 189 KLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQS-KVEDEQTLG 247
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
Q +++ E + ++ E+ + +R R K +Q + E+ L L EA T
Sbjct: 248 LQFQKKIKELQARIEELEEEIEA-ERATRAKTEKQRSDYARELE-ELSERLEEAGG-VTS 304
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ L K + E +K+ R E LR + + A+L EQ+ N +
Sbjct: 305 TQIELNKKREAEFLKLRRDLEEATLQHEAMVATLR--KKHADSVAELGEQIDNLQRVKQK 362
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHES--ETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
++ L+ ++ ++ + ++ E + ++++++ A ++S S L+
Sbjct: 363 LEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLS-ELTT 421
Query: 624 DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPT 683
K+ +T+ +L + L ++ + E L QL++ KA++ L
Sbjct: 422 QKSRLQTEAG-ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE-ENKAKN-ALGHA 478
Query: 684 PPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRK--------VEELEQDK 735
+++ + + E+E + AE++ L E R K EELE+ K
Sbjct: 479 LQSSRHDCDLLREQYEEE--QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 536
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVKVLEDEIDEVR---- 790
+ L +++++ ++ +V A T +R + + + ER L +D+ +
Sbjct: 537 KKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 596
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTL------IKSRSLDASDQQNVDLKRQLQVIEQEA 844
K L E + CE AEL + K+ ++L +K+ +A DQ +KR+ + +EQE
Sbjct: 597 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET-VKRENKNLEQEI 655
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSL---RSDKALDLNTKKTTQLENELKEAL 901
+ L + +L+ K+++L K L ++ AL+ K +++ EL +
Sbjct: 656 ADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 715
Query: 902 AKIKELEMICQDEKSEK-KVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
++I + ++ +DE+ E+ K + + L ++ +
Sbjct: 716 SEI-DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKKKMEGDLNEIEIQ 774
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L A ++ K + T+L L + E ++ +V + A L E+ +
Sbjct: 775 LSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV-EE 833
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEK-NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
+ E E KL++ + +NE+ L T+ L KLE D L++E
Sbjct: 834 LRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETD-------LMQLQSE 886
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+ S + E+ K ++ +LK
Sbjct: 887 VEDASRDARNAEEKAKKAITDAAMMAEELK 916
Score = 57.6 bits (133), Expect = 4e-07
Identities = 181/888 (20%), Positives = 330/888 (37%), Gaps = 82/888 (9%)
Query: 648 NNLRKTAARVE---EDNESLLLQLKKMATKARSRKLSPTPPANKLSIETAND--NDEKET 702
N+L KT +++E ED ES L Q KK+ K KL+ E+ D ND+++
Sbjct: 164 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDL-KLAQESILDLENDKQQL 222
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
DE L+ + E L+ KVE+ + +K++KEL ++I + + T
Sbjct: 223 DER--------LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT 274
Query: 763 ARRSLTTNSNKLAE-ERVKVLEDEIDEVRKKLIE--KERDCERLHAELSLAQKKPKTLIK 819
++ S+ E E + +E V IE K+R+ E L L + TL
Sbjct: 275 RAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA---TLQH 331
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS 879
+ +++ D +L EQ ++ R K Q LE + + + E L + +S+
Sbjct: 332 EAMVATLRKKHADSVAELG--EQIDNLQRVK-QKLEKEKSEFKLEIDDLS--SSMESVSK 386
Query: 880 DKALDLNTKKTTQ-LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
KA N +K + LE++L EA K +E++ + ++K TEA + L+ K+
Sbjct: 387 SKA---NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ-LEEKES 442
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC 998
+ L+ ++ A+ + + D L++ E+ +
Sbjct: 443 IVSQLSRSKQAFTQQTEELKRQLEE-ENKAKNALGHALQSSRHDCDL---LREQYEEEQE 498
Query: 999 EIGEMYVVMKNAGLSGKEMTAKTKLE-----KEIDEIRSKLSKNDSEFTNEKNRLQTEIA 1053
E+ + A + K + + +E++E + KL++ + + + + A
Sbjct: 499 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCA 558
Query: 1054 KLKDVNAKLEGD-KDVFANKYKALENE---NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
L+ +L+G+ +D+ + +A + N K L E E +L A LK
Sbjct: 559 SLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLK 618
Query: 1110 NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKK 1169
+ SL T + ++ + T+ + K + E+ K+
Sbjct: 619 ESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 678
Query: 1170 IG-----------DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV----- 1213
I + RI+ +L+ K + Q
Sbjct: 679 IELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQR 738
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAA-K 1272
+ L E+ + ++ + K E +E ++ + L S K
Sbjct: 739 TVETMQSALDAEVRRANEAIRLKK-KMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK 797
Query: 1273 DVHIKQLEDALRQTTNDKYDEATSP-------VEMVEMRXXXXXXXXXXXXXQDEL--NN 1323
D + L+DALR + K A E+ E+R + EL +N
Sbjct: 798 DTQL-HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSN 856
Query: 1324 AKIKLEKTEAES---SAAKLE--MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYW-ENKA 1377
+++L T+ S + KLE + QL+S++ ++ E
Sbjct: 857 ERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELK 916
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
KE DT ER K + + D + +AE LKG K +++ RI EL+ E
Sbjct: 917 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE----TRIRELEFEL 972
Query: 1438 E-ETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ 1484
E E K E L K E Y+ E+ V + + V+K Q +
Sbjct: 973 EGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVK 1020
Score = 38.7 bits (86), Expect = 0.21
Identities = 53/311 (17%), Positives = 134/311 (43%), Gaps = 24/311 (7%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ + + +QI + + L K +++E EK+DI L ++ A +++L+
Sbjct: 651 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA----LEEAEAALEHEEAKILR 706
Query: 322 LQQKVNELTTH-NEDLRDEKKHLTQKIREIESELETRPST-EAQTRQI-EQLRAKLLAAE 378
+Q ++ ++ + + + ++ + + Q R + +ET S +A+ R+ E +R K
Sbjct: 707 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRRANEAIRLKKKMEG 766
Query: 379 TLCE---ELMDENEDMKKELRDLXXXXXXMQDN--FREDQADEYSSLRRELEQTIKNCRV 433
L E +L N + L+ L ++D +D L+ +L + +
Sbjct: 767 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL 826
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L ++++ +Q E+ + E++LL+ R++ L + +L+
Sbjct: 827 LQAEVEELRATLEQTERARKLAEQELLD---------SNERVQLLHTQNTSLIHTKKKLE 877
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG--GSQEDPAQLLRDLQDSLEREA- 550
+L + S+ ++ + ++ +++ ++D + L ++ +LE+
Sbjct: 878 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 937
Query: 551 DLREQLRNAEE 561
DL+ +L AE+
Sbjct: 938 DLQHRLDEAEQ 948
>X51592-1|CAA35941.1| 1437|Homo sapiens fetal-myosin heavy chain (1437
AA) protein.
Length = 1437
Score = 95.1 bits (226), Expect = 2e-18
Identities = 178/941 (18%), Positives = 362/941 (38%), Gaps = 73/941 (7%)
Query: 190 ERERRSLSKSKEDEKTARYKDERSSTK--DDVNFLMQ--VKNSRNSTNLKPPVRGGPXXX 245
E++ L S E EK R ER+ K D+ + + N + L +
Sbjct: 530 EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDNENDKQQLDEKLEKKEFEI 589
Query: 246 XXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANI 305
+ +KE Q +IE L +E++ R + EK++SD L R L I
Sbjct: 590 SNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSD-LSRELEEI 648
Query: 306 DTANKYTTGRSSEVLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
+ G +S ++L +K E DL E+ L + + S
Sbjct: 649 SERLEEAGGATSAQVELNKKREAEFQKLRRDL--EEATLQHEAMVAALRKKHADSMAELG 706
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
QI+ L+ E EL E +D+ + ++ + D+ S L+ +
Sbjct: 707 EQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKDGGRSLEDQVSELKTKE 766
Query: 425 EQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEV 482
E+ + L+ + + + +A + ++ E + + ++ Q E +LE+E
Sbjct: 767 EEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEET 826
Query: 483 ARSTEVALRLQRELAEAN---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL 539
+A LQ + + ++ ++ + + S + R ++ D Q
Sbjct: 827 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTNTETDAIQRT 886
Query: 540 RDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
+L+++ ++ A L+E + E A C + + + D + D+ S +
Sbjct: 887 EELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVED--LMLDVERSNAACAA 944
Query: 599 IQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLR 651
+ K + S K+K + ++ + +E++ F Y + + LR
Sbjct: 945 LDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL--ETLR 1002
Query: 652 KTAARVEEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
+ ++++ L Q+ + + K+ K I+ A + E + + +
Sbjct: 1003 RENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKIL 1062
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
++ LELN+ ++ V RK+ E +++ + LK+ + + S S A R
Sbjct: 1063 RIQLELNQVKSEV-DRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRV---- 1117
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--Q 828
K +E +++E+ +L RL AE + + ++K L D +
Sbjct: 1118 --------KKKMEGDLNEMEIQL----NHANRLAAESLRNYRNTQGILKETQLHLDDALR 1165
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKAL 883
DLK QL ++E+ A++L+A+ + L A E+ + E + L + + L +
Sbjct: 1166 GQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1225
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+NTKK +LEN++ + ++++E+ ++ + + K T+A + LK +Q
Sbjct: 1226 LINTKK--KLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMM-AEELKKEQDTSAHL 1282
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
Q L + A K K +I K L+ V +LE GE+
Sbjct: 1283 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK----------LEARVRELE---GEV 1329
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
K + K + + KE+ + KN + ++LQ ++ K + E
Sbjct: 1330 ENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAE 1389
Query: 1064 GDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
+ +K++ L++E + E E+Q+NKL
Sbjct: 1390 EQSNANLSKFRKLQHE-------LEEAEERADIAESQVNKL 1423
Score = 93.5 bits (222), Expect = 7e-18
Identities = 190/1014 (18%), Positives = 383/1014 (37%), Gaps = 77/1014 (7%)
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
K K L+KS ++++ +K + Q + E + AK + LE L E LQL
Sbjct: 337 KIKPLLKSAE---TEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 393
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+++ D D + ++N++ + AKIKE+ ++E+ E T +K D
Sbjct: 394 QSEA---DSLADAEERCEQLIKNKI-QLEAKIKEVTERAEEEE-EINAELTAKKRKLEDE 448
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KK 991
+ + +K+L ++ I K + + ++
Sbjct: 449 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE-MAGLDETIAKLSKEKKALQETHQQ 507
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
++DL+ E ++ ++ K AKTKLE+++D++ L + +K R+ E
Sbjct: 508 TLDDLQAEEDKVNILTK----------AKTKLEQQVDDLEGSLEQE------KKLRMDLE 551
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
AK KLEGD + ++NEN + L E+++ +E +I+ L + +++
Sbjct: 552 RAK-----RKLEGDLKLAQES--TMDNENDK-----QQLDEKLEKKEFEISNLISKIEDE 599
Query: 1112 TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIG 1171
+++ + + + + K D ++ L+E+ ++ ++ G
Sbjct: 600 QAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE---KQRSDLSRELEEISERLEEAG 656
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
KR + R+D L H EL + D
Sbjct: 657 GATSAQVELNK--KREAEFQKLRRD----LEEATLQHEAMVAALRKKHADSMAELGEQID 710
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKY 1291
LQ K E + L+ E DL ++ E I+ + + KD + LED + + +
Sbjct: 711 NLQRVKQKLEKEKSELKMETDDLSSNAE-AISKAKGNLE-KDGG-RSLEDQVSELKTKEE 767
Query: 1292 DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK 1351
++ ++ R DE + +L +++ S+ E+ + K
Sbjct: 768 EQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETK 827
Query: 1352 LENXXXXXXXXXXXX--XXXSSYWENKA--KELDTDLQSERKKLDRMRIAHDKDVKNKDA 1407
+N Y E + EL L ++ + R + D +
Sbjct: 828 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTNTETDAIQRTE 887
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE 1467
EL K KL Q + + + E+T ++L++ + + E L++
Sbjct: 888 ELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDK 947
Query: 1468 EHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKLGTESAAWNTEKTE 1521
+ L+ K E+ Q EL QKE LST L ++K + E+ + E
Sbjct: 948 KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKN 1007
Query: 1522 MQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRDV-LEHHHDXXXXXXXX 1579
+Q I+ L E++ GG ++ E ++ +++Q + E++AA + + LEH
Sbjct: 1008 LQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1067
Query: 1580 XXXXXXDYER-VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMN 1638
+ +R +++ ++ ++R + K + EG +N
Sbjct: 1068 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALR-VKKKMEGDLN 1126
Query: 1639 TMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH------RNSISST 1692
M +L + + R N + +L+ Q + + G + + R ++
Sbjct: 1127 EMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQA 1186
Query: 1693 DEEEYRNKVALLEQQVACLEDELCESRLLASKL---NTELVSEKSSAEVRLAEMQSRLNE 1749
+ EE + E+ E EL ++ L NT L++ K E ++++QS + E
Sbjct: 1187 EIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEE 1246
Query: 1750 YEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLLQETSTLARDLRQTL 1799
+E + +A+ A A M KE+D +R+ + +DL+ L
Sbjct: 1247 VIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1300
Score = 88.2 bits (209), Expect = 3e-16
Identities = 222/1182 (18%), Positives = 461/1182 (39%), Gaps = 131/1182 (11%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + ++ + +L +E +EL ++ + KE DL
Sbjct: 337 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV--- 393
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG 465
+ +AD + EQ IKN L K+K+ +A++ E+ AE K ++
Sbjct: 394 -----QSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDE 448
Query: 466 PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETV--KVSR 523
++++ I +LE +A+ + + ++ + G + ++ K+ + + + +
Sbjct: 449 CSELKKD--IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQ 506
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
+L ++ED +L + LE++ D L L ++ + ++ D ++ +
Sbjct: 507 QTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 566
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIF 642
+ + + ++ + + ++ K ++ S E + + + K +E Q + +
Sbjct: 567 STMDNE-NDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIE----ELG 621
Query: 643 NHMAANNLRKTAARVEEDNESLLLQLKKMATKARSR--KLSPTPPANKLSIETANDNDEK 700
+ A R + A+ E+ L +L++++ + S NK E +
Sbjct: 622 EEIEAE--RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKR-EAEFQKLRR 678
Query: 701 ETDEADPAEMKLLLELNEQEA---TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
+ +EA ++ L ++ A L +++ L++ K+ L+K+ EL + ++
Sbjct: 679 DLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLS---- 734
Query: 758 GSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTL 817
SN A ++ L ++ + LED++ E++ K E++R L A+ + Q +
Sbjct: 735 -SNAEA---ISKAKGNLEKDGGRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEY 790
Query: 818 IKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA-KS 876
SR LD D L R Q A TQ +E +L+ E K L +A +S
Sbjct: 791 --SRQLDEKDALVSQLSRSKQ----------ASTQQIEELKHQLEEETKAKNALAHALQS 838
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
R D DL + Q E E +E A+++ E ++ + T ETD ++
Sbjct: 839 SRHD--CDLLRE---QYEEE-QEGKAELQRALSKANSEVAQWR------TNTETDAIQRT 886
Query: 937 QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL 996
+ + L +A++ + K + TK +L+ VEDL
Sbjct: 887 EELEEA---------------KKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDL 931
Query: 997 ECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFT---NEKNRLQTEIA 1053
++ NA + + + +K + E + K + +E E L TE+
Sbjct: 932 MLDVER-----SNAACAALDKKQRN-FDKVLSEWKQKYEETQAELEASQKESRSLSTELF 985
Query: 1054 KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
K+K+V E D + + L EN NL + LTE++ QI++L K
Sbjct: 986 KVKNV---YEESLD----QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKK---- 1034
Query: 1114 LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDX 1173
Q C Q++ ++Q K+++ +++ +K ++I
Sbjct: 1035 -QVEQEKCEIQAALEEAEASLEHEEGKILRIQLE----LNQVKSEVDRKIAEKDEEIDQL 1089
Query: 1174 XXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+ ++ ++ +R D + + L N RL+ E
Sbjct: 1090 KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQL-NHANRLAAESLRNYRN 1148
Query: 1233 LQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
Q +T+ + L+ +R + D + ++ +E I++L L QT +
Sbjct: 1149 TQGILKETQ---LHLDDALRG-QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSR-- 1202
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQD-ELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK 1351
++ E Q+ L N K KLE +++QL+S++ +
Sbjct: 1203 ------KIAEQELLDASERVQLLHTQNTSLINTKKKLEN----------DVSQLQSEVEE 1246
Query: 1352 -LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELA 1410
++ + E KE DT ER K + + D + +AE
Sbjct: 1247 VIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1306
Query: 1411 TLKGKLKILEQNSGAGAKRITELKQEYE---ETVKKL-EHSLALEKAEYEELTGKYELLE 1466
LKG K +++ + E++ E + E VK L +H +++ Y+ + +L
Sbjct: 1307 ALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLR 1366
Query: 1467 EEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ +V K + V+ + Q E +++ + L + + LQ +L
Sbjct: 1367 LQDLVDKLQAKVKSYKRQAE--EAEEQSNANLSKFRKLQHEL 1406
Score = 64.1 bits (149), Expect = 5e-09
Identities = 152/859 (17%), Positives = 338/859 (39%), Gaps = 55/859 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEK--SDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
++ +D+ LK+++D L +VEKEK ++ ++ L T + S+ K Q
Sbjct: 443 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQ 502
Query: 325 KVNELTTHNEDLRDEKKHLTQKIR-EIESELETRPSTEAQTRQ----IEQLRAKLLAAET 379
+ ++ T + ++K ++ K + ++E +++ + Q ++ +E+ + KL
Sbjct: 503 ETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 562
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
L +E +NE+ K++L + N DE ++ +L++ IK + +L
Sbjct: 563 LAQESTMDNENDKQQLDEKLEKKEFEISNLISKIEDE-QAVEIQLQKKIKELQARIEELG 621
Query: 440 KTERKADQLEQEKAEHEKKLL--EIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQREL 496
+ E +A++ + KAE ++ L E+ + ++ + E+ + E +L+R+L
Sbjct: 622 E-EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL 680
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
EA + +L K ++ + + Q L + L+ E D
Sbjct: 681 EEATLQHEAMVAALRKKHADSMAELGEQI----DNLQRVKQKLEKEKSELKMETDDLSSN 736
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN-SIQNKMIHAASTPSSKEK 615
A + + + L+ QV + T + + + + + Q + + S++
Sbjct: 737 AEAISKAKGNLEKDGGRSLEDQV--SELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQL 794
Query: 616 SDSPPL--SIDKTTE-ETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL-KKM 671
+ L + ++ + TQ +L + A N L D + L Q ++
Sbjct: 795 DEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ 854
Query: 672 ATKARSRKLSPTPPANKLSIETANDNDE-KETDEADPAEMKLLLELNEQEATV--LRRKV 728
KA ++ + T + D + T+E + A+ KL L E E V + K
Sbjct: 855 EGKAELQRALSKANSEVAQWRTNTETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKC 914
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
LE+ K+ L+ +V++L + A + R N +K+ E + + +E
Sbjct: 915 ASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQR-----NFDKVLSE----WKQKYEE 965
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
+ +L +++ L EL + + + L+ ++N +L++++ + ++ +
Sbjct: 966 TQAELEASQKESRSLSTELFKVKNVYEESLD--QLETLRRENKNLQQEISDLTEQ--IAE 1021
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
Q E + K Q E +K ++ A ++ +L+ K +++ EL + +++
Sbjct: 1022 GGKQIHELEKIKKQVEQEKCEI--QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1079
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+E + K T + TL ++ + L A
Sbjct: 1080 AEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLA 1139
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
+S + + T+L L + E ++ +V + A L L+ EI+
Sbjct: 1140 AESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANL----------LQAEIE 1189
Query: 1029 EIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
E+ + L + + + + E+ + L N K LEN+ S L ++ +
Sbjct: 1190 ELWATLEQTE----RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVE 1245
Query: 1089 TLTEEMKNREAQINKLSAD 1107
+ +E +N E + K D
Sbjct: 1246 EVIQESRNAEEKAKKAITD 1264
>X13988-1|CAA32167.1| 1940|Homo sapiens protein ( Human mRNA for
embryonic myosin heavy chain. ).
Length = 1940
Score = 95.1 bits (226), Expect = 2e-18
Identities = 175/912 (19%), Positives = 365/912 (40%), Gaps = 75/912 (8%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEEL-------EQDKEALKKQVKELTSKIS 750
+ E +E AE+ E E + L++ +++L E++K A + +VK LT ++S
Sbjct: 925 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELS 984
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ +T A T + +++ A + ++ ED+++ + K + E+ E L + L
Sbjct: 985 GLDETIA--KLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE 1042
Query: 811 QKKPKTLIKSR-----SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
+K L +++ L + + +DL+ Q +++ + L++ E QT
Sbjct: 1043 KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 1102
Query: 866 KKLQ-LLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTE 924
+ Q +K ++ + ++ ++ T+ + E K+ +ELE E SE+
Sbjct: 1103 LQFQKKIKELQARIEELEEEIEAERATRAKTE-KQRSDYARELE-----ELSERLEEAGG 1156
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
T + + K ++ ATL+ D+ +I
Sbjct: 1157 VTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQ---R 1213
Query: 985 TKLQLKKMVEDLECEIGEMYVVMKNAGLS--GKEMTAKTKLEKEIDEIRSK---LSKNDS 1039
K +L+K + + EI ++ M++ S E +T LE ++ E R K + ++ S
Sbjct: 1214 VKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT-LEDQLSEARGKNEEIQRSLS 1272
Query: 1040 EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
E T +K+RLQTE +L + +LE + + + L + Q TEE+K +
Sbjct: 1273 ELTTQKSRLQTEAGEL---SRQLEEKESIVSQ----LSRSKQAFTQQ----TEELKRQLE 1321
Query: 1100 QINKLSADLKNATSLQTTMSDC---MXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQD 1155
+ NK L +A LQ++ DC +V + TK + D
Sbjct: 1322 EENKAKNALAHA--LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1379
Query: 1156 ---KNKLLKEVGDK-TKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQ 1211
+ + L+E +K +++ D C +EK + V
Sbjct: 1380 AIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 1439
Query: 1212 AVVLANTHR---RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLEST 1268
A L R ++ E ++ +E QA + + +L E+ LK YE + LE T
Sbjct: 1440 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLE-T 1498
Query: 1269 IAAKDVHIKQ-LEDALRQ-----TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELN 1322
+ ++ +++Q + D Q T + +++ +E+ + +E
Sbjct: 1499 VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 1558
Query: 1323 NAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDT 1382
+I+LE T+ +S + ++A+ ++ +L+ N+A L
Sbjct: 1559 ILRIQLELTQVKSEIDR-KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKK 1617
Query: 1383 DLQSERKKLDRMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
++ + +++ ++++H ++ L +++G+LK + + + +LK E +
Sbjct: 1618 KMEGDLNEIE-IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLK----EQL 1672
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ------GELLHVQKELS 1495
+E L +AE EEL E E + + L E+ Q L+H +K+L
Sbjct: 1673 AIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLE 1732
Query: 1496 TALGEIKTLQEKLGTESA-AWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
T L ++++ E ++ A K + ++ +E R+ L+Q +
Sbjct: 1733 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1792
Query: 1555 ELRAANDRRDVL 1566
+L+ D + L
Sbjct: 1793 DLQHRLDEAEQL 1804
Score = 87.8 bits (208), Expect = 3e-16
Identities = 220/1056 (20%), Positives = 404/1056 (38%), Gaps = 96/1056 (9%)
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
E K++ + + ++ EL+ ++ K K L L Q+ DL QLQV + ++L
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKEL--EEKLVTLVQEKNDL--QLQVQAESENLL 900
Query: 848 RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
A+ + + K Q E K ++ + A+ A +L KK +LE+E E I +L
Sbjct: 901 DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINA-ELTAKKR-KLEDECSELKKDIDDL 958
Query: 908 EMICQDEKSEKKVRFTE-ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
E+ K EK+ TE K T+ L L++ +D
Sbjct: 959 ELTLA--KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED 1016
Query: 967 --DAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNA-----GLSGKEMT 1018
++ K ++ ++ DL + L Q KK+ DLE ++ +K A L +
Sbjct: 1017 KVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQ 1076
Query: 1019 AKTKLEK---EIDEIRSKLSKNDS---EFTNEKNRLQTEIAKLKD-------VNAKLEGD 1065
+L+K E +++SK+ + +F + LQ I +L++ AK E
Sbjct: 1077 LDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ 1136
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXX 1125
+ +A + + L T E K REA+ KL DL+ AT M +
Sbjct: 1137 RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKK 1196
Query: 1126 XXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK 1185
Q K++++K++ E+ D + + C+
Sbjct: 1197 HADSVAELGEQIDNLQRVKQ-----KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICR 1251
Query: 1186 RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI 1245
+E QLS + + Q L LS +L EK+ + ++ +++ F
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQL-EEKESIVSQLSRSKQAF- 1309
Query: 1246 TLEAEMRDLKADYENKIT-----SLESTIAAKDVHIKQLED----------ALRQTTND- 1289
T + E + + ENK +L+S+ D+ +Q E+ AL + ++
Sbjct: 1310 TQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1369
Query: 1290 -----KYD-EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAK-IKLEKTEAESSAAKLEM 1342
KY+ +A E +E Q E NAK LEKT+ E+
Sbjct: 1370 AQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG---EV 1426
Query: 1343 AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDV 1402
L D+ + + + W+ K +E +L++ K+ + K +
Sbjct: 1427 EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK-L 1485
Query: 1403 KN--KDA--ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL 1458
KN ++A +L T+K + K LEQ ++I E + E ++K + LEKA+ +
Sbjct: 1486 KNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE-LEKSRKQIELEKADIQLA 1544
Query: 1459 TGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAWNT 1517
+ E E R+ +E Q + E+ E + ++K Q + T +A +
Sbjct: 1545 LEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA 1604
Query: 1518 EKTEMQNSIASLQERLCG--GGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXX 1575
E +N L++++ G E++ + N + + + LR+ + + H D
Sbjct: 1605 E-VRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALR 1663
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK---AEITDTKTR 1632
ER + + + +EQ+E+ARK E+ D+ R
Sbjct: 1664 GQEDLKEQLAIVERRANLLQ----------AEVEELRATLEQTERARKLAEQELLDSNER 1713
Query: 1633 YE---GQMNTMRDELKSLHNQVSRFRRE-RDNYKQMLEAAQKSMAEIKNGDKSARIHRNS 1688
+ Q ++ K L + + + E D + A +K+ I + A +
Sbjct: 1714 VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE 1773
Query: 1689 ISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN 1748
++ E K LEQ V L+ L E+ LA K + + + E R+ E++ L
Sbjct: 1774 QDTSAHLERMKK--NLEQTVKDLQHRLDEAEQLALKGGKKQIQK---LETRIRELEFEL- 1827
Query: 1749 EYEEERLLSSGRARVAGLATRMELAWHKERDEQQRL 1784
E E+++ S + EL + E D + L
Sbjct: 1828 EGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863
Score = 71.7 bits (168), Expect = 2e-11
Identities = 177/876 (20%), Positives = 346/876 (39%), Gaps = 83/876 (9%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRS 316
S +++ + +E ++ LR ER +++ + D+ L + + +D N + +
Sbjct: 1026 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 1085
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQ----TRQIE 368
E +LQ KV + T + + K L +I E+E E+E TR TE Q R++E
Sbjct: 1086 FEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 1145
Query: 369 QLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
+L +L A + ++ N KK + +++ + +A ++LR++ ++
Sbjct: 1146 ELSERLEEAGGVTSTQIELN---KKREAEFLKLRRDLEEATLQHEA-MVATLRKKHADSV 1201
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEV 488
L ++ +R +LE+EK+E + LEI M+ ++ K +++ R+
Sbjct: 1202 AE---LGEQIDNLQRVKQKLEKEKSEFK---LEIDDLSSSMESVSKSKANLEKICRT--- 1252
Query: 489 ALRLQRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
L+ +L+EA K SL ++ Q ++ L+R E+ ++ L S +
Sbjct: 1253 ---LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR--QLEEKESIVSQLSRSKQ 1307
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAA 607
E+L+ EE K + D ++ E + +Q + A
Sbjct: 1308 AFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD-LLREQYEEEQEGKAELQRALSKAN 1366
Query: 608 STPSS-KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN-----LRKTAARVEEDN 661
S + + K ++ + + EE Q + A N L KT R++ +
Sbjct: 1367 SEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEV 1426
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQE 720
E L++ +++ + A + +K+ E +E + + EA E + L E
Sbjct: 1427 EDLMVDVERANSLAAALD-KKQRNFDKVLAEWKTKCEESQAELEASLKESRSL----STE 1481
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
L+ EE E +K++ K L +I+ +T+ A + T S K E
Sbjct: 1482 LFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE--LEKSRKQIELEKA 1539
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ-V 839
++ ++E L + + + L +L L Q K + R + D++ LKR Q
Sbjct: 1540 DIQLALEEAEAAL--EHEEAKILRIQLELTQVKSEI---DRKIAEKDEEIEQLKRNYQRT 1594
Query: 840 IEQEASVLRAKTQS----------LEAD-NE-KLQTENKKLQLLKNAKSLRSD----KAL 883
+E S L A+ +S +E D NE ++Q + Q + K LRS K
Sbjct: 1595 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT 1654
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD-TLKSKQXXXXX 942
L+ + + +LKE LA ++ + Q E E + AT ++T+ K +
Sbjct: 1655 QLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELR-----ATLEQTERARKLAEQELLD 1709
Query: 943 XXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL-TTKLQLKKMVEDLECEIG 1001
T K L+ D + + + D + + KK + D
Sbjct: 1710 SNERVQLLHTQNTSLIHTKKKLETDLMQ-LQSEVEDASRDARNAEEKAKKAITDAAMMAE 1768
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDVNA 1060
E+ K S K LE+ + +++ +L + + K ++Q +++++
Sbjct: 1769 EL---KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEF 1825
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LEG++ K L + E+ KN
Sbjct: 1826 ELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKN 1861
Score = 68.9 bits (161), Expect = 2e-10
Identities = 166/870 (19%), Positives = 356/870 (40%), Gaps = 67/870 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ +D+ LK+++D L +VEKEK T NK + E+ L + +
Sbjct: 942 RKLEDECSELKKDIDDLELTLAKVEKEKH----------ATENK-VKNLTEELSGLDETI 990
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAETLCEELM 385
+LT + L++ + ++ E ++ + T+++ +Q+E L + L E+
Sbjct: 991 AKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-------EQEK 1043
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
D+++ R L Q++ + + D+ R ++ + C++ S K++ +
Sbjct: 1044 KLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQS-KVEDEQTLG 1102
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
Q +++ E + ++ E+ + +R R K +Q + E+ L L EA T
Sbjct: 1103 LQFQKKIKELQARIEELEEEIEA-ERATRAKTEKQRSDYARELE-ELSERLEEAGG-VTS 1159
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ L K + E +K+ R E LR + + A+L EQ+ N +
Sbjct: 1160 TQIELNKKREAEFLKLRRDLEEATLQHEAMVATLR--KKHADSVAELGEQIDNLQRVKQK 1217
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHES--ETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
++ L+ ++ ++ + ++ E + ++++++ A ++S S L+
Sbjct: 1218 LEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLS-ELTT 1276
Query: 624 DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPT 683
K+ +T+ +L + L ++ + E L QL++ KA++ L+
Sbjct: 1277 QKSRLQTEAG-ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE-ENKAKN-ALAHA 1333
Query: 684 PPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRK--------VEELEQDK 735
+++ + + E+E + AE++ L E R K EELE+ +
Sbjct: 1334 LQSSRHDCDLLREQYEEE--QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAQ 1391
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVKVLEDEIDEVR---- 790
E L +++++ ++ +V A T +R + + + ER L +D+ +
Sbjct: 1392 EKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 1451
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTL------IKSRSLDASDQQNVDLKRQLQVIEQEA 844
K L E + CE AEL + K+ ++L +K+ +A DQ +KR+ + +EQE
Sbjct: 1452 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET-VKRENKNLEQEI 1510
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSL---RSDKALDLNTKKTTQLENELKEAL 901
+ L + +L+ K+++L K L ++ AL+ K +++ EL +
Sbjct: 1511 ADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 1570
Query: 902 AKIKELEMICQDEKSEK-KVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
++I + ++ +DE+ E+ K + + L ++ +
Sbjct: 1571 SEI-DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQ 1629
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L A ++ K + T+L L + E ++ +V + A L E+ +
Sbjct: 1630 LSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV-EE 1688
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEK-NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
+ E E KL++ + +NE+ L T+ L KLE D L++E
Sbjct: 1689 LRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETD-------LMQLQSE 1741
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+ S + E+ K ++ +LK
Sbjct: 1742 VEDASRDARNAEEKAKKAITDAAMMAEELK 1771
Score = 46.0 bits (104), Expect = 0.001
Identities = 52/250 (20%), Positives = 107/250 (42%), Gaps = 26/250 (10%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E LK+++ I+ +R ++ E + L L + A K E+L ++V L T N
Sbjct: 1666 EDLKEQLAIVERRANLLQAEVEE-LRATLEQTERARKLA---EQELLDSNERVQLLHTQN 1721
Query: 334 EDLRDEKKHLTQKIREIESELE--TRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDM 391
L KK L + +++SE+E +R + A+ + + + + AE L +E D + +
Sbjct: 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE-QDTSAHL 1780
Query: 392 KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL------------- 438
++ ++L +Q E + ++++++ R L F+L
Sbjct: 1781 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG 1840
Query: 439 -KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-----RENRIKELEQEVARSTEVALRL 492
+K ER+ +L + E K +L + D +Q + + +E +++ +
Sbjct: 1841 LRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKA 1900
Query: 493 QRELAEANSK 502
Q EL EA +
Sbjct: 1901 QHELEEAEER 1910
Score = 37.9 bits (84), Expect = 0.37
Identities = 53/311 (17%), Positives = 134/311 (43%), Gaps = 24/311 (7%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ + + +QI + + L K +++E EK+DI L ++ A +++L+
Sbjct: 1506 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA----LEEAEAALEHEEAKILR 1561
Query: 322 LQQKVNELTTH-NEDLRDEKKHLTQKIREIESELETRPST-EAQTR-QIEQLRAKLLAAE 378
+Q ++ ++ + + + ++ + + Q R + +ET S +A+ R + E +R K
Sbjct: 1562 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEG 1621
Query: 379 TLCE---ELMDENEDMKKELRDLXXXXXXMQDN--FREDQADEYSSLRRELEQTIKNCRV 433
L E +L N + L+ L ++D +D L+ +L + +
Sbjct: 1622 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL 1681
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L ++++ +Q E+ + E++LL+ R++ L + +L+
Sbjct: 1682 LQAEVEELRATLEQTERARKLAEQELLD---------SNERVQLLHTQNTSLIHTKKKLE 1732
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG--GSQEDPAQLLRDLQDSLEREA- 550
+L + S+ ++ + ++ +++ ++D + L ++ +LE+
Sbjct: 1733 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1792
Query: 551 DLREQLRNAEE 561
DL+ +L AE+
Sbjct: 1793 DLQHRLDEAEQ 1803
Score = 37.5 bits (83), Expect = 0.48
Identities = 84/475 (17%), Positives = 187/475 (39%), Gaps = 24/475 (5%)
Query: 1326 IKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQ 1385
+K +TE E + K E + K +LAK E + + + + +L
Sbjct: 841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLL 900
Query: 1386 SERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLE 1445
++ D++ I ++ K E+ + + A +++ + E ++ + LE
Sbjct: 901 DAEERCDQL-IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 959
Query: 1446 HSLALEKAEYEELTGKYELLEEEHV---VTKARLTVEKEQAQGELLHVQKELSTALGEIK 1502
+LA + E K + L EE T A+LT EK+ Q H Q AL +++
Sbjct: 960 LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQE--AHQQ-----ALDDLQ 1012
Query: 1503 TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
++K+ + N K++++ + L+ L + ++ R++ ++R+ E +
Sbjct: 1013 AEEDKVN----SLNKTKSKLEQQVEDLESSL----EQEKKLRVDLERNKRKLEGDLKLAQ 1064
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
+L+ +D + SK++ IE+ E+
Sbjct: 1065 ESILDLENDKQQLDERLKKKDFEYCQLQSKVE-DEQTLGLQFQKKIKELQARIEELEEEI 1123
Query: 1623 KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSA 1682
+AE T+ + E Q + EL+ L ++ ++ + + +++ + A
Sbjct: 1124 EAE-RATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA 1182
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAE 1742
+ ++ +T +++ + VA L +Q+ L+ + S+ E+ SS E +
Sbjct: 1183 TLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME---SV 1239
Query: 1743 MQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+S+ N + R L + G ++ + + ++ RL E L+R L +
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294
>X13100-1|CAA31492.1| 1167|Homo sapiens myosin heavy chain (1167 AA)
protein.
Length = 1167
Score = 95.1 bits (226), Expect = 2e-18
Identities = 175/912 (19%), Positives = 365/912 (40%), Gaps = 75/912 (8%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEEL-------EQDKEALKKQVKELTSKIS 750
+ E +E AE+ E E + L++ +++L E++K A + +VK LT ++S
Sbjct: 152 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELS 211
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ +T A T + +++ A + ++ ED+++ + K + E+ E L + L
Sbjct: 212 GLDETIA--KLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE 269
Query: 811 QKKPKTLIKSR-----SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
+K L +++ L + + +DL+ Q +++ + L++ E QT
Sbjct: 270 KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 329
Query: 866 KKLQ-LLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTE 924
+ Q +K ++ + ++ ++ T+ + E K+ +ELE E SE+
Sbjct: 330 LQFQKKIKELQARIEELEEEIEAERATRAKTE-KQRSDYARELE-----ELSERLEEAGG 383
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
T + + K ++ ATL+ D+ +I
Sbjct: 384 VTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQ---R 440
Query: 985 TKLQLKKMVEDLECEIGEMYVVMKNAGLS--GKEMTAKTKLEKEIDEIRSK---LSKNDS 1039
K +L+K + + EI ++ M++ S E +T LE ++ E R K + ++ S
Sbjct: 441 VKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT-LEDQLSEARGKNEEIQRSLS 499
Query: 1040 EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
E T +K+RLQTE +L + +LE + + + L + Q TEE+K +
Sbjct: 500 ELTTQKSRLQTEAGEL---SRQLEEKESIVSQ----LSRSKQAFTQQ----TEELKRQLE 548
Query: 1100 QINKLSADLKNATSLQTTMSDC---MXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQD 1155
+ NK L +A LQ++ DC +V + TK + D
Sbjct: 549 EENKAKNALAHA--LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 606
Query: 1156 ---KNKLLKEVGDK-TKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQ 1211
+ + L+E +K +++ D C +EK + V
Sbjct: 607 AIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 666
Query: 1212 AVVLANTHR---RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLEST 1268
A L R ++ E ++ +E QA + + +L E+ LK YE + LE T
Sbjct: 667 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLE-T 725
Query: 1269 IAAKDVHIKQ-LEDALRQ-----TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELN 1322
+ ++ +++Q + D Q T + +++ +E+ + +E
Sbjct: 726 VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 785
Query: 1323 NAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDT 1382
+I+LE T+ +S + ++A+ ++ +L+ N+A L
Sbjct: 786 ILRIQLELTQVKSEIDR-KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKK 844
Query: 1383 DLQSERKKLDRMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
++ + +++ ++++H ++ L +++G+LK + + + +LK E +
Sbjct: 845 KMEGDLNEIE-IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALQTQEDLK----EQL 899
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ------GELLHVQKELS 1495
+E L +AE EEL E E + + L E+ Q L+H +K+L
Sbjct: 900 AIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLE 959
Query: 1496 TALGEIKTLQEKLGTESA-AWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
T L ++++ E ++ A K + ++ +E R+ L+Q +
Sbjct: 960 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1019
Query: 1555 ELRAANDRRDVL 1566
+L+ D + L
Sbjct: 1020 DLQHRLDEAEQL 1031
Score = 90.2 bits (214), Expect = 6e-17
Identities = 168/867 (19%), Positives = 346/867 (39%), Gaps = 64/867 (7%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+KE Q +IE L++E++ R + EK++SD R L + + G +S ++L +K
Sbjct: 336 IKELQARIEELEEEIEAERATRAKTEKQRSDYA-RELEELSERLEEAGGVTSTQIELNKK 394
Query: 326 VN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
E DL E+ L + + S QI+ L+ E E
Sbjct: 395 REAEFLKLRRDL--EEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 452
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKLKKTE 442
E +D+ + + ++ R EDQ E E+++++ L+ + + +
Sbjct: 453 KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSE---LTTQKSRLQ 509
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGM--QRENRIKELEQEVARSTEVALRLQRELAEAN 500
+A +L ++ E E + ++ Q E ++LE+E +A LQ + +
Sbjct: 510 TEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 569
Query: 501 ---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD-LREQL 556
++ ++ + + S + R + D Q +L+++ E+ A L++
Sbjct: 570 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSE 629
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS-KEK 615
E A C + + + D +V D+ + ++ ++ K + + K K
Sbjct: 630 EQVEAVNAKCASLEKTKQRLQGEVEDLMV--DVERANSLAAALDKKQRNFDKVLAEWKTK 687
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK- 674
+ ++ + +E++ + N A V+ +N++L ++ + +
Sbjct: 688 CEESQAELEASLKESR-SLSTELFKLKN--AYEEALDQLETVKRENKNLEQEIADLTEQI 744
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
A + K ++ IE + + +EA+ A L +EA +LR ++E L Q
Sbjct: 745 AENGKTIHELEKSRKQIELEKADIQLALEEAEAA-------LEHEEAKILRIQLE-LTQV 796
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN--SNKLAEERVKVLEDEIDEVRKK 792
K + +++ E +I + + + T + +L S A K +E +++E+ +
Sbjct: 797 KSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQ 856
Query: 793 LIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
L R L Q + K LD + Q DLK QL ++E+ A++L+A+ +
Sbjct: 857 LSHANRQAAETLKHLRSVQGQLKDT--QLHLDDALQTQEDLKEQLAIVERRANLLQAEVE 914
Query: 853 SLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
L A E+ + E + L + + L + ++TKK +LE +L + +++++
Sbjct: 915 ELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK--KLETDLMQLQSEVEDA 972
Query: 908 EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDD 967
++ + + K T+A + LK +Q Q L +
Sbjct: 973 SRDARNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1031
Query: 968 AQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEI-GEMYVVMKNAGLSGKEMTAKTKLEKE 1026
A K K +I K L+ + +LE E+ GE KN S K + + KE
Sbjct: 1032 ALKGGKKQIQK----------LETRIRELEFELEGEQ---KKNTE-SVKGLRKYERRVKE 1077
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+ + KN + ++LQ ++ K + + + K++ ++E
Sbjct: 1078 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHE------- 1130
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATS 1113
+ E E+Q+NKL A ++ TS
Sbjct: 1131 LEEAEERADIAESQVNKLRAKTRDFTS 1157
Score = 88.2 bits (209), Expect = 3e-16
Identities = 220/1056 (20%), Positives = 404/1056 (38%), Gaps = 96/1056 (9%)
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
E K++ + + ++ EL+ ++ K K L L Q+ DL QLQV + ++L
Sbjct: 72 ETEKEMATMKEEFQKTKDELAKSEAKRKEL--EEKLVTLVQEKNDL--QLQVQAESENLL 127
Query: 848 RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
A+ + + K Q E K ++ + A+ A +L KK +LE+E E I +L
Sbjct: 128 DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINA-ELTAKKR-KLEDECSELKKDIDDL 185
Query: 908 EMICQDEKSEKKVRFTE-ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
E+ K EK+ TE K T+ L L++ +D
Sbjct: 186 ELTLA--KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED 243
Query: 967 --DAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNA-----GLSGKEMT 1018
++ K ++ ++ DL + L Q KK+ DLE ++ +K A L +
Sbjct: 244 KVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQ 303
Query: 1019 AKTKLEK---EIDEIRSKLSKNDS---EFTNEKNRLQTEIAKLKD-------VNAKLEGD 1065
+L+K E +++SK+ + +F + LQ I +L++ AK E
Sbjct: 304 LDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ 363
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXX 1125
+ +A + + L T E K REA+ KL DL+ AT M +
Sbjct: 364 RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKK 423
Query: 1126 XXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK 1185
Q K++++K++ E+ D + + C+
Sbjct: 424 HADSVAELGEQIDNLQRVKQ-----KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICR 478
Query: 1186 RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI 1245
+E QLS + + Q L LS +L EK+ + ++ +++ F
Sbjct: 479 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQL-EEKESIVSQLSRSKQAF- 536
Query: 1246 TLEAEMRDLKADYENKIT-----SLESTIAAKDVHIKQLED----------ALRQTTND- 1289
T + E + + ENK +L+S+ D+ +Q E+ AL + ++
Sbjct: 537 TQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 596
Query: 1290 -----KYD-EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAK-IKLEKTEAESSAAKLEM 1342
KY+ +A E +E Q E NAK LEKT+ E+
Sbjct: 597 AQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG---EV 653
Query: 1343 AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDV 1402
L D+ + + + W+ K +E +L++ K+ + K +
Sbjct: 654 EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK-L 712
Query: 1403 KN--KDA--ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL 1458
KN ++A +L T+K + K LEQ ++I E + E ++K + LEKA+ +
Sbjct: 713 KNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE-LEKSRKQIELEKADIQLA 771
Query: 1459 TGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAWNT 1517
+ E E R+ +E Q + E+ E + ++K Q + T +A +
Sbjct: 772 LEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA 831
Query: 1518 EKTEMQNSIASLQERLCG--GGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXX 1575
E +N L++++ G E++ + N + + + LR+ + + H D
Sbjct: 832 E-VRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALQ 890
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK---AEITDTKTR 1632
ER + + + +EQ+E+ARK E+ D+ R
Sbjct: 891 TQEDLKEQLAIVERRANLLQ----------AEVEELRATLEQTERARKLAEQELLDSNER 940
Query: 1633 YE---GQMNTMRDELKSLHNQVSRFRRE-RDNYKQMLEAAQKSMAEIKNGDKSARIHRNS 1688
+ Q ++ K L + + + E D + A +K+ I + A +
Sbjct: 941 VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE 1000
Query: 1689 ISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN 1748
++ E K LEQ V L+ L E+ LA K + + + E R+ E++ L
Sbjct: 1001 QDTSAHLERMKK--NLEQTVKDLQHRLDEAEQLALKGGKKQIQK---LETRIRELEFEL- 1054
Query: 1749 EYEEERLLSSGRARVAGLATRMELAWHKERDEQQRL 1784
E E+++ S + EL + E D + L
Sbjct: 1055 EGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1090
Score = 74.5 bits (175), Expect = 3e-12
Identities = 178/876 (20%), Positives = 346/876 (39%), Gaps = 83/876 (9%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRS 316
S +++ + +E ++ LR ER +++ + D+ L + + +D N + +
Sbjct: 253 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 312
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQ----TRQIE 368
E +LQ KV + T + + K L +I E+E E+E TR TE Q R++E
Sbjct: 313 FEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 372
Query: 369 QLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
+L +L A + ++ N KK + +++ + +A ++LR++ ++
Sbjct: 373 ELSERLEEAGGVTSTQIELN---KKREAEFLKLRRDLEEATLQHEA-MVATLRKKHADSV 428
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEV 488
L ++ +R +LE+EK+E + LEI M+ ++ K +++ R+
Sbjct: 429 AE---LGEQIDNLQRVKQKLEKEKSEFK---LEIDDLSSSMESVSKSKANLEKICRT--- 479
Query: 489 ALRLQRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
L+ +L+EA K SL ++ Q ++ L+R E+ ++ L S +
Sbjct: 480 ---LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR--QLEEKESIVSQLSRSKQ 534
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAA 607
E+L+ EE K + D ++ E + +Q + A
Sbjct: 535 AFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD-LLREQYEEEQEGKAELQRALSKAN 593
Query: 608 STPSS-KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN-----LRKTAARVEEDN 661
S + + K ++ + + EE Q + A N L KT R++ +
Sbjct: 594 SEVAQWRTKYETDAIQRTEELEEAQEKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEV 653
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQE 720
E L++ +++ + A + +K+ E +E + + EA E + L E
Sbjct: 654 EDLMVDVERANSLAAALD-KKQRNFDKVLAEWKTKCEESQAELEASLKESRSL----STE 708
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
L+ EE E +K++ K L +I+ +T+ A + T S K E
Sbjct: 709 LFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE--LEKSRKQIELEKA 766
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ-V 839
++ ++E L + + + L +L L Q K + R + D++ LKR Q
Sbjct: 767 DIQLALEEAEAAL--EHEEAKILRIQLELTQVKSEI---DRKIAEKDEEIEQLKRNYQRT 821
Query: 840 IEQEASVLRAKTQS----------LEAD-NE-KLQTENKKLQLLKNAKSLRSD----KAL 883
+E S L A+ +S +E D NE ++Q + Q + K LRS K
Sbjct: 822 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT 881
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD-TLKSKQXXXXX 942
L+ Q + +LKE LA ++ + Q E E + AT ++T+ K +
Sbjct: 882 QLHLDDALQTQEDLKEQLAIVERRANLLQAEVEELR-----ATLEQTERARKLAEQELLD 936
Query: 943 XXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL-TTKLQLKKMVEDLECEIG 1001
T K L+ D + + + D + + KK + D
Sbjct: 937 SNERVQLLHTQNTSLIHTKKKLETDLMQ-LQSEVEDASRDARNAEEKAKKAITDAAMMAE 995
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDVNA 1060
E+ K S K LE+ + +++ +L + + K ++Q +++++
Sbjct: 996 EL---KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEF 1052
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LEG++ K L + E+ KN
Sbjct: 1053 ELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKN 1088
Score = 69.7 bits (163), Expect = 1e-10
Identities = 166/870 (19%), Positives = 357/870 (41%), Gaps = 67/870 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ +D+ LK+++D L +VEKEK T NK + E+ L + +
Sbjct: 169 RKLEDECSELKKDIDDLELTLAKVEKEKH----------ATENK-VKNLTEELSGLDETI 217
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAETLCEELM 385
+LT + L++ + ++ E ++ + T+++ +Q+E L + L E+
Sbjct: 218 AKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-------EQEK 270
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
D+++ R L Q++ + + D+ R ++ + C++ S K++ +
Sbjct: 271 KLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQS-KVEDEQTLG 329
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
Q +++ E + ++ E+ + +R R K +Q + E+ L L EA T
Sbjct: 330 LQFQKKIKELQARIEELEEEIEA-ERATRAKTEKQRSDYARELE-ELSERLEEAGG-VTS 386
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ L K + E +K+ R E LR + + A+L EQ+ N +
Sbjct: 387 TQIELNKKREAEFLKLRRDLEEATLQHEAMVATLR--KKHADSVAELGEQIDNLQRVKQK 444
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHES--ETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
++ L+ ++ ++ + ++ E + ++++++ A ++S S L+
Sbjct: 445 LEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLS-ELTT 503
Query: 624 DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPT 683
K+ +T+ +L + L ++ + E L QL++ KA++ L+
Sbjct: 504 QKSRLQTEAG-ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE-ENKAKN-ALAHA 560
Query: 684 PPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRK--------VEELEQDK 735
+++ + + E+E + AE++ L E R K EELE+ +
Sbjct: 561 LQSSRHDCDLLREQYEEE--QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAQ 618
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVKVLEDEIDEVR---- 790
E L +++++ ++ +V A T +R + + + ER L +D+ +
Sbjct: 619 EKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 678
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTL------IKSRSLDASDQQNVDLKRQLQVIEQEA 844
K L E + CE AEL + K+ ++L +K+ +A DQ +KR+ + +EQE
Sbjct: 679 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET-VKRENKNLEQEI 737
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSL---RSDKALDLNTKKTTQLENELKEAL 901
+ L + +L+ K+++L K L ++ AL+ K +++ EL +
Sbjct: 738 ADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 797
Query: 902 AKIKELEMICQDEKSEK-KVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
++I + ++ +DE+ E+ K + + L ++ +
Sbjct: 798 SEI-DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQ 856
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L A ++ K + T+L L ++ E ++ +V + A L E+ +
Sbjct: 857 LSHANRQAAETLKHLRSVQGQLKDTQLHLDDALQTQEDLKEQLAIVERRANLLQAEV-EE 915
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEK-NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
+ E E KL++ + +NE+ L T+ L KLE D L++E
Sbjct: 916 LRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETD-------LMQLQSE 968
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+ S + E+ K ++ +LK
Sbjct: 969 VEDASRDARNAEEKAKKAITDAAMMAEELK 998
Score = 39.9 bits (89), Expect = 0.091
Identities = 103/492 (20%), Positives = 200/492 (40%), Gaps = 77/492 (15%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ + + +QI + + L K +++E EK+DI L ++ A +++L+
Sbjct: 733 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA----LEEAEAALEHEEAKILR 788
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
+Q ++ ++ K + +KI E + E+E +T +E +++ L A
Sbjct: 789 IQLELTQV----------KSEIDRKIAEKDEEIEQLKRNYQRT--VETMQSALDA----- 831
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+ NE ++ + + M+ + E + + S R+ +T+K+ R + +LK T
Sbjct: 832 -EVRSRNEAIRLKKK--------MEGDLNEIEI-QLSHANRQAAETLKHLRSVQGQLKDT 881
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+ D Q + E K+ L IV +R + + E E R+T R+LAE
Sbjct: 882 QLHLDDALQTQ-EDLKEQLAIV------ERRANLLQAEVEELRATLEQTERARKLAE--Q 932
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
+ SN + + T + T+ + D QL +++D+ R+A RNAEE
Sbjct: 933 ELLDSNERVQLLHTQNTSLIH----TKKKLETDLMQLQSEVEDA-SRDA------RNAEE 981
Query: 562 ETANCKQVNPPTFLDKQVMTDNIVTCDIHES----ETVTNSIQNKMIHAASTPSSKEKSD 617
+ K + + +++ + + + E +Q+++ A K
Sbjct: 982 KAK--KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ 1039
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV-------EEDNESLL----- 665
L T + F+L N + LRK RV EED +++L
Sbjct: 1040 IQKLE----TRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDL 1095
Query: 666 ---LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEA 721
LQ+K + K ++ + A+ A E+ + AD AE ++ L ++
Sbjct: 1096 VDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDF 1155
Query: 722 TVLRRKVEELEQ 733
T R V E E+
Sbjct: 1156 TSSRMVVHESEE 1167
Score = 37.5 bits (83), Expect = 0.48
Identities = 84/475 (17%), Positives = 187/475 (39%), Gaps = 24/475 (5%)
Query: 1326 IKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQ 1385
+K +TE E + K E + K +LAK E + + + + +L
Sbjct: 68 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLL 127
Query: 1386 SERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLE 1445
++ D++ I ++ K E+ + + A +++ + E ++ + LE
Sbjct: 128 DAEERCDQL-IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 186
Query: 1446 HSLALEKAEYEELTGKYELLEEEHV---VTKARLTVEKEQAQGELLHVQKELSTALGEIK 1502
+LA + E K + L EE T A+LT EK+ Q H Q AL +++
Sbjct: 187 LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQE--AHQQ-----ALDDLQ 239
Query: 1503 TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
++K+ + N K++++ + L+ L + ++ R++ ++R+ E +
Sbjct: 240 AEEDKVN----SLNKTKSKLEQQVEDLESSL----EQEKKLRVDLERNKRKLEGDLKLAQ 291
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
+L+ +D + SK++ IE+ E+
Sbjct: 292 ESILDLENDKQQLDERLKKKDFEYCQLQSKVE-DEQTLGLQFQKKIKELQARIEELEEEI 350
Query: 1623 KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSA 1682
+AE T+ + E Q + EL+ L ++ ++ + + +++ + A
Sbjct: 351 EAE-RATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA 409
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAE 1742
+ ++ +T +++ + VA L +Q+ L+ + S+ E+ SS E +
Sbjct: 410 TLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME---SV 466
Query: 1743 MQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+S+ N + R L + G ++ + + ++ RL E L+R L +
Sbjct: 467 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 521
>AB023217-1|BAA76844.2| 1956|Homo sapiens KIAA1000 protein protein.
Length = 1956
Score = 93.9 bits (223), Expect = 5e-18
Identities = 186/947 (19%), Positives = 382/947 (40%), Gaps = 78/947 (8%)
Query: 186 SIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRN----STNLKPPVRGG 241
+++ E++ L + E E+ AR ER K + N + ++ N +L +R
Sbjct: 1046 NLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1105
Query: 242 PXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR 301
+ VKE Q QI+ LK++++ R ++E+E++D L +
Sbjct: 1106 ELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERAD-LTQD 1164
Query: 302 LANIDTANKYTTGRSSEVLKLQQK-VNELTTHNEDLRDEKKHLTQKIREIES-ELETRPS 359
LA+++ + G S L++ +K ++ + D+ + H ++ ++
Sbjct: 1165 LADLNERLEEVGGSSLAQLEITKKQETKIQKLHRDMEEATLHFETTSASLKKRHADSLAE 1224
Query: 360 TEAQTRQIEQLRAKL----LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQA- 414
E Q ++Q++ KL + ++L+ E M + + ++ E A
Sbjct: 1225 LEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAK 1284
Query: 415 -DEYSSLRREL-EQTIKNCRVLSFKLKKTERK---ADQLEQEKAEHEKKLLEIVGGPDGM 469
D+ + L +L Q K L++ E K +QL +EK+ +++ ++ G +
Sbjct: 1285 LDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRG---QL 1341
Query: 470 QRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG 529
++E + + + + L RE E + + E V+ R
Sbjct: 1342 EKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQ------WRM 1395
Query: 530 GSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDI 589
+ + Q DL+D+ ++E +R Q AN + + + + D+
Sbjct: 1396 KYENNVIQRTEDLEDA-KKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDL 1454
Query: 590 HESETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN 648
+ + + K + + + K+K + +D + +E Q L + N +
Sbjct: 1455 GKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQ-ALSTELLKLKNTYEES 1513
Query: 649 NLRKTAARVEEDNESLLLQLKKMATKAR--SRKLSPTPPANKLSIETANDNDEKETDEAD 706
+ + R +N++L ++ + + R ++ L+ KL IE +EK +
Sbjct: 1514 IVGQETLR--RENKNLQEEISNLTNQVREGTKNLTEMEKVKKL-IE-----EEKTEVQVT 1565
Query: 707 PAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS 766
E + LE NE + +L ++E LE K L++++ E +I + + + + + S
Sbjct: 1566 LEETEGALERNESK--ILHFQLELLEA-KAELERKLSEKDEEIENFRRKQQCTIDSLQSS 1622
Query: 767 LTTNSNKLAE--ERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
L + + E K +E++++E+ +L R L Q + K L LD
Sbjct: 1623 LDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDL--QMQLD 1680
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
S Q N DLK Q+ V E+ S+L+++ + L + LQ + ++ + L + L + + ++
Sbjct: 1681 DSTQLNSDLKEQVAVAERRNSLLQSELEDLRS----LQEQTERGRRLSEEELLEATERIN 1736
Query: 885 LNTKKTTQLENELKEALAKI----KELEMI---CQDEKSEKKVRFTEATKKETDTLKSKQ 937
L + T L ++ K+ A + KE E + CQ+ + + K EA ++ LK KQ
Sbjct: 1737 LFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANL-SEELKKKQ 1795
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE 997
Q L + A + +I K L+ V +LE
Sbjct: 1796 DTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQK----------LESRVRELE 1845
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
GE+ ++ + + + + KE+ + KN S + ++LQ ++ K
Sbjct: 1846 ---GELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQ 1902
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
E + + +KYK ++E N+ K E + E+Q+NKL
Sbjct: 1903 QVEVAETQANQYLSKYKKQQHE----LNEVK---ERAEVAESQVNKL 1942
Score = 79.8 bits (188), Expect = 9e-14
Identities = 178/882 (20%), Positives = 346/882 (39%), Gaps = 60/882 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+++ VKE +++E ++ L R ++E E ++ ID E
Sbjct: 937 LEARVKELSERVEEEEEINSELTARGRKLEDECFELK----KEIDDLETMLVKSEKEKRT 992
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREI-ESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ KV LT E L ++ L + + + E+ +T + ++ L L E
Sbjct: 993 TEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQ 1052
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
+EL E +K + ++ N + + R +E + R L+ +L+K
Sbjct: 1053 VDELEGALEQERKARMNCERELHKLEGNLKLN--------RESMENLESSQRHLAEELRK 1104
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN 500
E + Q+ K E+EK L+ + + + +IK+L++++ +++RE A+
Sbjct: 1105 KELELSQMNS-KVENEKGLVAQLQ-KTVKELQTQIKDLKEKLEAERTTRAKMERERADLT 1162
Query: 501 SKFTGSNPSLMKV-----PQPETVKVSRSSLTRGGSQEDPAQL-LRDLQDSLE-READLR 553
N L +V Q E K + + + + A L SL+ R AD
Sbjct: 1163 QDLADLNERLEEVGGSSLAQLEITKKQETKIQKLHRDMEEATLHFETTSASLKKRHADSL 1222
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS-----IQNKMIHAAS 608
+L E KQ D Q+ D+++T + N+ + + +H A+
Sbjct: 1223 AELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEAT 1282
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
K + L+ KT ++ L L N L + + E L QL
Sbjct: 1283 AKLDKVTQLANDLAAQKTKLWSESGEFLRRLEE-KEALINQLSREKSNFTRQIEDLRGQL 1341
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
+K TK++S A + + + E+E + AE+ L E R K
Sbjct: 1342 EK-ETKSQSALAHALQKAQR-DCDLLREQYEEEQEVK--AELHRTLSKVNAEMVQWRMKY 1397
Query: 729 EE-LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
E + Q E L+ KEL ++ + +N SL ++L E L D +
Sbjct: 1398 ENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANAR-NASLERARHQLQLELGDALSD-LG 1455
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
+VR ++ ++L + +LA K K LDAS ++ L +L ++
Sbjct: 1456 KVRSAAARLDQ--KQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEES 1513
Query: 848 RAKTQSLEADNEKLQTENKKL--QLLKNAKSLRS-DKALDLNTKKTTQLENELKE---AL 901
++L +N+ LQ E L Q+ + K+L +K L ++ T+++ L+E AL
Sbjct: 1514 IVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGAL 1573
Query: 902 ----AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXX 957
+KI ++ + K+E + + +E + E + + KQ
Sbjct: 1574 ERNESKILHFQLELLEAKAELERKLSEKDE-EIENFRRKQQCTIDSLQSSLDSEAKSRIE 1632
Query: 958 QATLKSLKDDAQKSFKPRIP---KKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLS 1013
LK ++ + ++ ++ ++ T L QL+ ++DL+ ++ + N+ L
Sbjct: 1633 VTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDS--TQLNSDLK 1690
Query: 1014 GKEMTAKTK---LEKEIDEIRSKLSKND-SEFTNEKNRLQ-TEIAKL-KDVNAKLEGDKD 1067
+ A+ + L+ E++++RS + + +E+ L+ TE L N L K
Sbjct: 1691 EQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKK 1750
Query: 1068 VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
++ E + +C+ E+ K + LS +LK
Sbjct: 1751 KLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELK 1792
Score = 76.2 bits (179), Expect = 1e-12
Identities = 166/872 (19%), Positives = 352/872 (40%), Gaps = 88/872 (10%)
Query: 299 LRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQK----IREIESEL 354
++ L + G E +LQ+ + + E+L+ ++ LTQ+ I ++++E
Sbjct: 858 IKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQ 917
Query: 355 ETRPSTEAQTR-----------QIEQLRAKLLAAETLCEELM-------DENEDMKKELR 396
ET + E Q ++++L ++ E + EL DE ++KKE+
Sbjct: 918 ETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEID 977
Query: 397 DLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHE 456
DL + R + + +L E+E ++ L+ K + Q + E
Sbjct: 978 DLETMLVKSEKEKRTTE-HKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEE 1036
Query: 457 KKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL--AEANSKFTGSNPSLMKVP 514
+KL + ++ E ++ ELE + + + + +REL E N K + ++
Sbjct: 1037 EKLSSL--SKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESS 1094
Query: 515 Q---PETVKVSRSSLTRGGSQ-EDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
Q E ++ L++ S+ E+ L+ LQ +++ +L+ Q+++ +E+ +
Sbjct: 1095 QRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVK---ELQTQIKDLKEKLEAERTTR 1151
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
++ +T ++ + E +S+ I +K ++ + + EE
Sbjct: 1152 AKMERERADLTQDLADLNERLEEVGGSSLAQLEI--------TKKQETKIQKLHRDMEEA 1203
Query: 631 QFHFDLPYLSIFNHMA---------ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
HF+ S+ A NL++ ++E+D L L++ + T+ +
Sbjct: 1204 TLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRA 1263
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE--QDKEALK 739
AN + T + E +L +L Q+ + E L ++KEAL
Sbjct: 1264 ---KANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALI 1320
Query: 740 KQVKELTSKISSVTKTSAG--SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKE 797
Q+ S + + G T +S ++ + A+ +L ++ +E ++ E
Sbjct: 1321 NQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELH 1380
Query: 798 RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD 857
R +++AE+ + K + + R+ D D + +L +LQ + V A+ SLE
Sbjct: 1381 RTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKK-ELAIRLQEAAEAMGVANARNASLERA 1439
Query: 858 NEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE 917
+LQ E L + +RS A + Q + + +ALA K +K E
Sbjct: 1440 RHQLQLELG--DALSDLGKVRSAAA------RLDQKQLQSGKALADWK--------QKHE 1483
Query: 918 KKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIP 977
+ +A++KE L ++ + K+L+++ + ++
Sbjct: 1484 ESQALLDASQKEVQALSTE---LLKLKNTYEESIVGQETLRRENKNLQEEI-SNLTNQVR 1539
Query: 978 KKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNA--GLSGKEMTAKTKLEKEIDEIRSKLS 1035
+ +LT ++KK++E+ + E+ + A K + + +L + E+ KLS
Sbjct: 1540 EGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLS 1599
Query: 1036 KNDSEFTNEKNRLQTEIAKLK-DVNAKLEGDKDVFANKYKALENEN------SNLSNQCK 1088
+ D E N + + Q I L+ ++++ + +V K K E+ N S + Q
Sbjct: 1600 EKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVS 1659
Query: 1089 TLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
T+ + + QI L L ++T L + + +
Sbjct: 1660 EATKSLGQLQIQIKDLQMQLDDSTQLNSDLKE 1691
Score = 66.9 bits (156), Expect = 7e-10
Identities = 147/824 (17%), Positives = 310/824 (37%), Gaps = 47/824 (5%)
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIR-SKLSKNDSEFT 1042
TT+ ++K + E++E + E + A +E +T + ++E + S LSK + +
Sbjct: 992 TTEHKVKNLTEEVEF-LNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLE 1050
Query: 1043 NEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
+ + L+ + + + E + K NL + + L EE++ +E +++
Sbjct: 1051 QQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELS 1110
Query: 1103 KLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKE 1162
++++ ++N L + + K+++++ L ++
Sbjct: 1111 QMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRA------KMERERADLTQD 1164
Query: 1163 VGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRL 1222
+ D +++ + K+ E ++ + L H
Sbjct: 1165 LADLNERLEEVGGSSLAQLEITKKQETKIQKLHRDMEEATLHFETTSAS---LKKRHADS 1221
Query: 1223 SIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDA 1282
EL + + LQ K E L+ E+ DL E + + ++ ++L +A
Sbjct: 1222 LAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEA 1281
Query: 1283 LRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT----EAESSAA 1338
+ DK + + + + + + E ++ EK+ + E
Sbjct: 1282 TAKL--DKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRG 1339
Query: 1339 KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAH 1398
+LE + KS A E KA EL L ++ + R+ +
Sbjct: 1340 QLEK-ETKSQSALAHALQKAQRDCDLLREQYEEEQEVKA-ELHRTLSKVNAEMVQWRMKY 1397
Query: 1399 DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL 1458
+ +V + +L K +L I Q + A A + + ++++ H L LE +
Sbjct: 1398 ENNVIQRTEDLEDAKKELAIRLQEA-AEAMGVANARNA---SLERARHQLQLELGDALSD 1453
Query: 1459 TGKYEL----LEEEHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKL 1508
GK L+++ + + L K E++Q L QKE LST L ++K E+
Sbjct: 1454 LGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEES 1513
Query: 1509 GTESAAWNTEKTEMQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRD-VL 1566
E +Q I++L ++ G + E ++ +++ + E++ + + L
Sbjct: 1514 IVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGAL 1573
Query: 1567 EHHHDXXXXXXXXXXXXXXDYER-VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAE 1625
E + + ER +S+ ++ K+R E
Sbjct: 1574 ERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSR-IE 1632
Query: 1626 ITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIK--NGDKSAR 1683
+T K + E +N M +L + QVS + + ++ Q + + N D +
Sbjct: 1633 VTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQ 1692
Query: 1684 I----HRNSISSTDEEEYRNKVALLEQQVACLEDELCES--RL-LASKLNTELVSEKSSA 1736
+ RNS+ ++ E+ R+ E+ E+EL E+ R+ L NT L+S+K
Sbjct: 1693 VAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKL 1752
Query: 1737 EVRLAEMQSRLNEYEEERLLSSGRARVAGL-ATRMELAWHKERD 1779
E +A MQ E +E + +A+ A + A + K++D
Sbjct: 1753 EADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQD 1796
Score = 48.4 bits (110), Expect = 3e-04
Identities = 98/496 (19%), Positives = 186/496 (37%), Gaps = 29/496 (5%)
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALEN---ENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
+ K +V ++ G K+ A KALE + L + +LT+E + Q+ L
Sbjct: 861 LVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETL 920
Query: 1109 KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTK 1168
N C + + +++ KL E + K
Sbjct: 921 ANVEE------QCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKK 974
Query: 1169 KIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTS 1228
+I D + E ++ + V A V+ H++ +L
Sbjct: 975 EIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHM 1034
Query: 1229 EKDELQARF---IKTESKFITLEAEM---RDLKADYENKITSLESTIAAKDVHIKQLEDA 1282
E+++L + +K E + LE + R + + E ++ LE + ++ LE +
Sbjct: 1035 EEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESS 1094
Query: 1283 LRQTTND---KYDEATSPVEMVEM-RXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAA 1338
R + K E + VE + Q ++ + K KLE +
Sbjct: 1095 QRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKM 1154
Query: 1339 KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAH 1398
+ E A L DLA L + E K ++L D++ + +
Sbjct: 1155 ERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKIQKLHRDMEEATLHFETTSASL 1214
Query: 1399 DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL 1458
K ++ D+ LA L+G+++ L+Q K ++L+ E ++ + ++E + KA E+L
Sbjct: 1215 KK--RHADS-LAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVE-QMTRAKANAEKL 1270
Query: 1459 TGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE-IKTLQEKLGTESAAWNT 1517
YE E H T A+L + Q +L + +L + GE ++ L+EK + +
Sbjct: 1271 CTLYE--ERLHEAT-AKLD-KVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQL-SR 1325
Query: 1518 EKTEMQNSIASLQERL 1533
EK+ I L+ +L
Sbjct: 1326 EKSNFTRQIEDLRGQL 1341
>X52889-1|CAA37068.1| 1934|Homo sapiens cardiac beta myosin heavy
chain protein.
Length = 1934
Score = 93.5 bits (222), Expect = 7e-18
Identities = 164/837 (19%), Positives = 341/837 (40%), Gaps = 72/837 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R +VEK +SD L R L I + G +S ++
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSD-LSRELEEISERLEEAGGATSCQIE 1162
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 1163 MNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E E +D+ + + ++ R EDQ +E+ R + E+T ++ L+ +
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH---RSKAEETQRSVNDLTSQR 1277
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGG--PDGMQRENRIKELEQEVARSTEVALRLQRE- 495
K + + +L ++ E E + ++ G Q E+ ++LE+EV +A LQ
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1337
Query: 496 -----LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
L E + T + L +V +V++ R + D Q +L+++ ++ A
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ---WRTKYETDAIQRTEELEEAKKKLA 1394
Query: 551 D-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L+E E A C + + + D +V D+ S ++ K +
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVERSNAAAAALDKKQRNFDKI 1452
Query: 610 PSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ K+K + ++ + +E + F Y H+ ++ ++E+
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL--ETFKRENKNLQEEIS 1510
Query: 663 SLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L QL T K+ A K+ +++A + E + + ++ LE N+ +A
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
+ R+ E+ E+ ++A + ++ + S +TS + T +R A K
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETRSRNE--------ALRVKKK 1617
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQV 839
+E +++E+ +L R+ AE K ++L+K + D + N DLK + +
Sbjct: 1618 MEGDLNEMEIQL----SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENK-----KLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+E+ + L+A+ + L A E+ + K ++ + + L S +N KK +++
Sbjct: 1674 VERRNN-LQAELEELRAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKK--KMD 1730
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+L + +++E C++ + + K T+A + LK +Q
Sbjct: 1731 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTI 1789
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
Q L + A K K ++ K + +L+ +E + E M+ +
Sbjct: 1790 KDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEAEQKRNAESVKGMRKSERRI 1846
Query: 1015 KEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE+T +T +L+ +D+++ K+ + + + T ++K + V +L+
Sbjct: 1847 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1903
Score = 81.8 bits (193), Expect = 2e-14
Identities = 182/953 (19%), Positives = 365/953 (38%), Gaps = 55/953 (5%)
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +A K + +L+ S+ + +L+ ++ + QE + L+ + Q+ E DN E
Sbjct: 846 EKEMASMKEEFTALKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA-EQDN-LADAEE 903
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE-KKVRFTE 924
+ QL+KN L + K ++N + + E E AK + +E C + K + + T
Sbjct: 904 RCDQLIKNKIQLEA-KVKEMNERLEDEEEMNA-ELTAKKRNVEDECSELKRDIDDLELTL 961
Query: 925 A-TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
A +KE ++K + L+ A + K T
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
K++L++ V+DLE + + V + + +++ KL +E I +ND + +
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE--SIMDL--ENDKQQLD 1077
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
E RL+ + +L +NA++E ++ + + K L+ + + + L E R A++ K
Sbjct: 1078 E--RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR-AKVEK 1134
Query: 1104 LSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKLLK 1161
L +DL + + + + ++ T + + L K
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
+ D ++G+ ++ + + D VT + T
Sbjct: 1195 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
E S+ +E Q S+ L+ E +L + K + K + +QLED
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
RQ +E + + +E AK +L++ S A E
Sbjct: 1315 LKRQLE----EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSE 1367
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+AQ ++ K E + +A+E + ++ L++ + +
Sbjct: 1368 VAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
+++ ++ L++ K + E KQ+YEE+ +LE S ++ EL
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 1462 YELLEE--EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
EE EH+ T R E + Q E+ + ++L ++ I L EK+ + A EK
Sbjct: 1485 KNAYEESLEHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHEL-EKVRKQLEA---EK 1537
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDVLEHHH----DXX 1573
E+Q+++ + L ++ RA+L N + ER+L ++ + + +H D
Sbjct: 1538 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSL 1597
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRY 1633
+ RV K ++ K+ ++ + DT+ +
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Query: 1634 EGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTD 1693
+ + D+LK V R R+N + LE + A ++ ++S ++ + T
Sbjct: 1658 DDAVRA-NDDLKENIAIVER----RNNLQAELEELR---AVVEQTERSRKLADRELIETS 1709
Query: 1694 EEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
E +V LL Q L ++ + S+L TE+ E++ E R AE +++
Sbjct: 1710 E-----RVQLLHSQNTSLINQKKKMDADLSQLQTEV--EEAVQECRNAEEKAK 1755
Score = 73.3 bits (172), Expect = 8e-12
Identities = 192/1082 (17%), Positives = 410/1082 (37%), Gaps = 83/1082 (7%)
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L+++LE+ R++L EE+ + Q L Q DN+ + + + N IQ
Sbjct: 859 LKEALEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ- 914
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ A ++ D ++ + T ++ + L ++L T A+VE++
Sbjct: 915 --LEAKVKEMNERLEDEEEMNAELTAKKRNVEDECSELK----RDIDDLELTLAKVEKEK 968
Query: 662 ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ ++K + + A ++ K +++ A+ ++ D+ E K+
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQAEEDKV------NT 1019
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNKLAEER 778
T + K+E+ D E +Q K++ + + G + S+ N + +ER
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER 1079
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV-----DL 833
+K + E++ + ++ +++ +L +L Q + + L + + + + V DL
Sbjct: 1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 1139
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
R+L+ I + T N+K + E +K++ +L+ + KK
Sbjct: 1140 SRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
EL E + ++ ++ + EKSE K+ + T +K+K
Sbjct: 1200 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ T +S+ D S + ++ + +L+ +L K+ + + G++ + L
Sbjct: 1260 RSKAEETQRSVND--LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDLK 1316
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANK 1072
+++ + K + + +++D + E+ +TE A+L+ V +K + + K
Sbjct: 1317 -RQLEEEVKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1374
Query: 1073 YKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDCMXXXXX 1127
Y+ L K L + ++ E + ++A K LQ + D M
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434
Query: 1128 XXXXXXXXXXXXXXXXXQVDNYT-KIDQDKNKL------LKEVGDKTKKIGDXXXXXXXX 1180
+ + K ++ +++L + + + K+ +
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 1181 XXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKT 1240
KR K L +T + + +EL S +E +A
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATS 1296
E K + + E +KA+ E K+ + + AK H++ L+ +L T + +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 1297 PVEMV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+M EM Q ++ + + L+ T+ + A LK ++A +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAEL 1409
E E K D +L SER + L + K DA+L
Sbjct: 1675 ERRNNLQAELEELRAVVEQ-TERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADL 1733
Query: 1410 ATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK--- 1461
+ L+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K
Sbjct: 1734 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1793
Query: 1462 YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
+ L E E + K +L + + EL QK + ++ ++ + ++ + +
Sbjct: 1794 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTY 1851
Query: 1516 NTEK-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDV 1565
TE+ +Q+ + LQ ++ + E A A + + + EL A +R D+
Sbjct: 1852 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1911
Query: 1566 LE 1567
E
Sbjct: 1912 AE 1913
Score = 67.7 bits (158), Expect = 4e-10
Identities = 174/877 (19%), Positives = 351/877 (40%), Gaps = 90/877 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRSSE 318
+++ D +EG ++ +R ER +++ + D+ L + + +D N + + E
Sbjct: 1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 1086
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ--------TRQIEQL 370
+ L ++ + L+ + K L +I E+E ELE + A+ +R++E++
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146
Query: 371 RAKLLAA--ETLCEELMD-----ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE 423
+L A T C+ M+ E + M+++L + R+ AD + E
Sbjct: 1147 SERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVA----E 1202
Query: 424 LEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVA 483
L + I N + + KL+K E+ +LE + + + +I+ +++ R E +
Sbjct: 1203 LGEQIDNLQRVKQKLEK-EKSEFKLELD--DVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 484 RS-TEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
RS E R +L +K N L + Q + + S LTRG + Q L DL
Sbjct: 1260 RSKAEETQRSVNDLTSQRAKLQTENGELSR--QLDEKEALISQLTRG--KLTYTQQLEDL 1315
Query: 543 QDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS--IQ 600
+ LE E + L +A + + L +Q + ++ + NS Q
Sbjct: 1316 KRQLEEEVKAKNALAHALQSAR-----HDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1370
Query: 601 NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED 660
+ + E+ + + + +E + + + ++L KT R++ +
Sbjct: 1371 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV------NAKCSSLEKTKHRLQNE 1424
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQ 719
E L++ +++ + A + +K+ E +E +++ E+ E + L
Sbjct: 1425 IEDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----ST 1479
Query: 720 EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERV 779
E L+ EE + E K++ K L +IS +T+ GS+ L +L E++
Sbjct: 1480 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLEAEKM 1538
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QLQ 838
+ L+ ++E L +E + L A+L Q K + R L D++ KR L+
Sbjct: 1539 E-LQSALEEAEASLEHEEG--KILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLR 1592
Query: 839 VIEQEASVLRAKTQS----------LEAD-NE---KLQTENK-KLQLLKNAKSLRS-DKA 882
V++ + L A+T+S +E D NE +L N+ + K KSL+S K
Sbjct: 1593 VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 883 LDLNTKKTTQLENELKEALAKIKELEMI-CQDEKSEKKVRFTEATKKETD-TLKSKQXXX 940
+ + ++LKE +A ++ + + E+ V TE ++K D L
Sbjct: 1653 TQIQLDDAVRANDDLKENIAIVERRNNLQAELEELRAVVEQTERSRKLADRELIETSERV 1712
Query: 941 XXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEI 1000
A L L+ + +++ + + + KK + D
Sbjct: 1713 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ-------ECRNAEEKAKKAITDAAMMA 1765
Query: 1001 GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDS-EFTNEKNRLQTEIAKLKDVN 1059
E+ K S K +E+ I +++ +L + + K +LQ A+++++
Sbjct: 1766 EEL---KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE 1822
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
+LE ++ A K + + E+ KN
Sbjct: 1823 NELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1859
Score = 66.9 bits (156), Expect = 7e-10
Identities = 200/1127 (17%), Positives = 421/1127 (37%), Gaps = 78/1127 (6%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + E + + L+ L +E +EL ++ + +E DL
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTALKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG 465
QDN + A+E +Q IKN L K+K+ + + E+ AE K +
Sbjct: 895 QDNLAD--AEE------RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRNVEDE 946
Query: 466 PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETV--KVSR 523
++R+ I +LE +A+ + + ++ + G + + K+ + + + +
Sbjct: 947 CSELKRD--IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
+L ++ED L + LE++ DL L ++ + ++ D ++ +
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIF 642
+I+ + ++ + + ++ K + + E + + K +E Q + +
Sbjct: 1065 SIMDLE-NDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIE----ELE 1119
Query: 643 NHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
+ A R A+VE+ L +L+++ S +L A IE N E E
Sbjct: 1120 EELEAE--RTARAKVEKLRSDLSRELEEI-----SERLEEAGGATSCQIE-MNKKREAEF 1171
Query: 703 DEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ + L+ +E A LR+K V EL + + L++ VK+ K S K
Sbjct: 1172 QKMRRDLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEFKLELD 1229
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
T+ + L E+ + LED+++E R K E +R L ++ + Q + L
Sbjct: 1230 DVTSNMEQIIKAKANL-EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGEL- 1287
Query: 819 KSRSLDASDQQNVDLKR-QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSL 877
SR LD + L R +L +Q + R + ++A N LQ ++ L
Sbjct: 1288 -SRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA----LQSARHDCDL 1342
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
++ + T+ +L+ L +A +++ + + + ++ EA KK L+ +
Sbjct: 1343 LREQ-YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1401
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS--FKPRIPKKPTDLTTKL-QLKKMVE 994
Q ++ L D ++S + KK + L + K+ E
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1461
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
+ + E+ ++ LS + K E+ ++ + + F E LQ EI+
Sbjct: 1462 ESQSELESSQKEARS--LSTELFKLKNAYEESLEHLET--------FKRENKNLQEEISD 1511
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSL 1114
L + K LE E L + + +++ E +I L A L+
Sbjct: 1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI--LRAQLEFNQIK 1569
Query: 1115 QTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEV-GDKTKKIGDX 1173
+D T+ + ++ K++ GD +
Sbjct: 1570 AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1629
Query: 1174 XXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL 1233
K+++ S KD +A RR +++ +E +EL
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLQ--AELEEL 1687
Query: 1234 QARFIKTESKFITLEAEMRDLKADYE---NKITSLESTIAAKDVHIKQL----EDALRQT 1286
+A +TE + E+ + + ++ TSL + D + QL E+A+++
Sbjct: 1688 RAVVEQTERSRKLADRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEC 1747
Query: 1287 TNDK-------YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES-SAA 1338
N + D A E+ + + + + + + +L++ E +
Sbjct: 1748 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGG 1807
Query: 1339 KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAH 1398
K ++ +L++ + +LEN E + KEL + +RK L R++
Sbjct: 1808 KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLV 1867
Query: 1399 DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLE 1445
DK ++ K + + E+ + + +++ E +E ++ +
Sbjct: 1868 DK----LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1910
Score = 65.3 bits (152), Expect = 2e-09
Identities = 155/829 (18%), Positives = 333/829 (40%), Gaps = 71/829 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANID-TANKYTTGRSSEV 319
+ +D+ LK+++D L +VEKEK L +A +D K T + +
Sbjct: 941 RNVEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 320 LKLQQKVNELTTHNE---DLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLL 375
QQ +++L + L K L Q++ ++E LE R +L L
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ +L ++ + + + L+ + ++QA S L+++L++ L
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA-LGSQLQKKLKELQARIEELE 1119
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQR 494
+L+ ++E+ +++ ++L EI + ++ + E+ + E +++R
Sbjct: 1120 EELEAERTARAKVEKLRSDLSRELEEI---SERLEEAGGATSCQIEMNKKREAEFQKMRR 1176
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L EA + + +L K S+ G Q D L+ ++ LE+E E
Sbjct: 1177 DLEEATLQHEATAAALR--------KKHADSVAELGEQIDN---LQRVKQKLEKEKS--E 1223
Query: 555 QLRNAEEETANCKQ-VNPPTFLDKQVMT----DNIVTCDIHESETVTNSI--QNKMIHAA 607
++ T+N +Q + L+K T N E++ N + Q +
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNLRKTAARVEEDNESLL 665
+ S++ + L T + + L L + + A N A + + LL
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 666 LQLKKMATKARSRKLSPTPPANK--LSIETANDNDE-KETDEADPAEMKLLLELNEQEAT 722
+ + T+A++ AN T + D + T+E + A+ KL L E E
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 723 V--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
V + K LE+ K L+ ++++L + +A + R N +K+ E
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR-----NFDKILAE--- 1455
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
+ + +E + +L +++ L EL + + ++ L+ ++N +L+ ++ +
Sbjct: 1456 -WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDL 1512
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAK-SLRSDKALDLNTK-KTTQLENEL 897
++ LE ++L+ E +LQ L+ A+ SL ++ L + + Q++ E+
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI 1572
Query: 898 KEALA-KIKELEMICQDE---KSEKKVRFTEATKKETDTLKSK---QXXXXXXXXXXXXX 950
+ LA K +E+E ++ + T+ + L+ K +
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632
Query: 951 XXXXXXXQATLKSLKD---DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVM 1007
Q +KSL+ D Q + + DL + + + +L+ E+ E+ V+
Sbjct: 1633 NRMAAEAQKQVKSLQSLLKDTQIQLDDAV-RANDDLKENIAIVERRNNLQAELEELRAVV 1691
Query: 1008 KNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK 1056
+ S K A +L + + ++ S+N S N+K ++ ++++L+
Sbjct: 1692 EQTERSRK--LADRELIETSERVQLLHSQNTS-LINQKKKMDADLSQLQ 1737
Score = 59.3 bits (137), Expect = 1e-07
Identities = 206/1093 (18%), Positives = 416/1093 (38%), Gaps = 95/1093 (8%)
Query: 477 ELEQEVARSTE--VALRLQRELAEANSK-FTGSNPSLMKVPQPETVKVSRSSLTRGGSQE 533
E E+E+A E AL+ E +EA K SL++ ++V ++E
Sbjct: 844 EREKEMASMKEEFTALKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903
Query: 534 DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI--VTCDIHE 591
QL+++ ++ EA ++E E+E +++N K+ + D + DI +
Sbjct: 904 RCDQLIKN---KIQLEAKVKEMNERLEDE----EEMNAELTAKKRNVEDECSELKRDIDD 956
Query: 592 SETVTNSIQNKMIHAASTPSSKEKSDSPPLS--IDKTTEETQFHFDLPYLSIFNHMA--- 646
E ++ + HA + L I K T+E + + ++ + A
Sbjct: 957 LELTLAKVEKEK-HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1015
Query: 647 -ANNLRKTAARVEE---DNESLLLQLKK--MATKARSRKLSPTPPANKLSIETANDNDEK 700
N L K ++E+ D E L Q KK M + RKL + SI +ND++
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL-ENDKQ 1074
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSN 760
+ DE L+ + E L ++E+ + L+K++KEL ++I + + +
Sbjct: 1075 QLDER--------LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEE-ELEAE 1125
Query: 761 TTARRSLTTNSNKLAEERVKVLE--DEIDEVRKKLIE--KERDCE-----RLHAELSLAQ 811
TAR + + L+ E ++ E +E IE K+R+ E R E +L
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSCQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 812 KKPKTLIKSRSLDASDQ--QNVD-LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL 868
+ ++ + D+ + + +D L+R Q +E+E S + + + ++ E Q K
Sbjct: 1186 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME--QIIKAKA 1243
Query: 869 QLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
L K ++L + + TQ N+L AK++ + EK+ ++ T+
Sbjct: 1244 NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTR 1303
Query: 928 KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL 987
+ L Q A L+S + D + + + K
Sbjct: 1304 GK---LTYTQQLEDLKRQLEEEVKAKNALAHA-LQSARHDCDLLRE----QYEEETEAKA 1355
Query: 988 QLKKMVEDLECEIGEMYVVMKNAGLSGKEMT--AKTKLEK---EIDEIRSKLSKNDSEFT 1042
+L++++ E+ + + + E AK KL + E +E ++ S
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 1043 NEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
K+RLQ EI L + K + + + + + E+++ + +
Sbjct: 1416 KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1475
Query: 1103 KLSADL-KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLK 1161
LS +L K + + ++ ++++ + +L
Sbjct: 1476 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA 1535
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV-----VLA 1216
E + + + R + + + K + QA V+
Sbjct: 1536 EKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVD 1595
Query: 1217 NTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRD---LKADYENKITSLESTIAAKD 1273
+ L E S + L+ + K E +E ++ + A+ + ++ SL+S + KD
Sbjct: 1596 SLQTSLDAETRSRNEALRVKK-KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL--KD 1652
Query: 1274 VHIKQLEDALRQTTNDKYDEA------TSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK 1327
I QL+DA+R + K + A E+ E+R EL +
Sbjct: 1653 TQI-QLDDAVRANDDLKENIAIVERRNNLQAELEELRAVVEQTERSRKLADRELIETSER 1711
Query: 1328 LEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXX--------XXXXXXXXSSYWENKAKE 1379
++ +++++ + ++ +DL++L+ + E KE
Sbjct: 1712 VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE 1771
Query: 1380 LDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYE- 1438
DT ER K + + D + +AE LKG K L++ + EL+ E +
Sbjct: 1772 QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKR 1831
Query: 1439 --ETVKKLEHS-LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELS 1495
E+VK + S +++ Y+ + LL + +V K +L V+ + Q E +++ +
Sbjct: 1832 NAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAE--EAEEQAN 1889
Query: 1496 TALGEIKTLQEKL 1508
T L + + +Q +L
Sbjct: 1890 TNLSKFRKVQHEL 1902
Score = 33.5 bits (73), Expect = 7.9
Identities = 35/167 (20%), Positives = 74/167 (44%), Gaps = 7/167 (4%)
Query: 1624 AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSAR 1683
A++T K + D+L++ ++V+ + + +Q ++ + S+ + K
Sbjct: 990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
Query: 1684 IHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEK---SSAEVRL 1740
+ + D + + + LE L++ L + + LN + E+ S + +L
Sbjct: 1050 RAKRKLEG-DLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKL 1108
Query: 1741 AEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQE 1787
E+Q+R+ E EEE L + AR R +L+ +E +E L+E
Sbjct: 1109 KELQARIEELEEE-LEAERTARAKVEKLRSDLS--RELEEISERLEE 1152
>AF111783-1|AAD29949.1| 1939|Homo sapiens myosin heavy chain IIb
protein.
Length = 1939
Score = 93.5 bits (222), Expect = 7e-18
Identities = 163/866 (18%), Positives = 348/866 (40%), Gaps = 72/866 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R + EK++SD L R L I + G +S ++
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQIE 1166
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
L +K E DL E+ L + + S +QI+ L+ E
Sbjct: 1167 LNKKREAEFQKMRRDL--EESTLQHEATAAALRKKHADSVAELGKQIDSLQRVKQKLEKE 1224
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
EL E D+ + + + R EDQ E + E ++ I LS +
Sbjct: 1225 KSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE---LSAQK 1281
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQREL 496
+ ++ + ++ E + + ++ G Q E ++LE+E + +A LQ
Sbjct: 1282 ARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSAR 1341
Query: 497 AEAN---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
+ + ++ + ++ + + S + R + D Q +L+++ ++ L
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKK---LA 1398
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQVMTDNI--VTCDIHESETVTNSIQNKMIHAASTPS 611
++L++AEE KQ + + + + D+ S ++ K + +
Sbjct: 1399 QRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLA 1458
Query: 612 S-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNESL 664
K+K + ++ + +E++ F Y +H+ L++ ++++ L
Sbjct: 1459 EWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHL--ETLKRENKNLQQEISDL 1516
Query: 665 LLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATV 723
Q+ + K+ K ++T+ + E + + +++ LELN+ ++ +
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
RK+ E +++ + LK+ + + S S A R K E + +E
Sbjct: 1577 -DRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALR-----IKKKMEGDLNEME 1630
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+++ ++ E R+ L Q LD + + DLK QL ++E+
Sbjct: 1631 IQLNHANRQAAEALRNLRNTQGILKDTQ---------LHLDDAIRGQDDLKEQLAMVERR 1681
Query: 844 ASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
A++++A+ + L A E+ + E + L + + L + +NTKK +LE ++
Sbjct: 1682 ANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKK--KLETDIS 1739
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
+ +++++ ++ + + K T+A + LK +Q Q
Sbjct: 1740 QIQGEMEDIVQEARNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNMEQTVKDLQ 1798
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
L + A K K +I K + +++++ ++E E + + V GL E
Sbjct: 1799 LRLGEAEQLALKGGKKQIQK------LEARVRELESEVESE--QKHNVEAVKGLRKHERR 1850
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALEN 1078
K +L + +E R KN + ++LQT++ K + E +V K++ L++
Sbjct: 1851 VK-ELTYQTEEDR----KNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQH 1905
Query: 1079 ENSNLSNQCKTLTEEMKNREAQINKL 1104
E + E E+Q+NKL
Sbjct: 1906 E-------LEEAEERADIAESQVNKL 1924
Score = 88.2 bits (209), Expect = 3e-16
Identities = 206/1130 (18%), Positives = 430/1130 (38%), Gaps = 83/1130 (7%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + E+ + +L E +EL ++ + +E DL
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV--- 895
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG 465
+ +AD + +Q IK L K+K+ +A+ E+ AE K ++
Sbjct: 896 -----QAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
Query: 466 PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETV--KVSR 523
++++ I +LE +A+ + + ++ + G + ++ K+ + + + +
Sbjct: 951 CSELKKD--IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
+L +ED L + LE++ DL L ++ + ++ D ++ +
Sbjct: 1009 QTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE 1068
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIF 642
+ + + ++ + + ++ K ++ E + + + K +E Q + +
Sbjct: 1069 STMDTE-NDKQQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIE----ELE 1123
Query: 643 NHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
+ A R + A+ E+ L +L+++ S +L A IE N E E
Sbjct: 1124 EEIEAE--RASRAKAEKQRSDLSRELEEI-----SERLEEAGGATSAQIE-LNKKREAEF 1175
Query: 703 DEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ + L+ +E A LR+K V EL + ++L++ VK+ K S K
Sbjct: 1176 QKMRRDLEESTLQ-HEATAAALRKKHADSVAELGKQIDSLQR-VKQKLEKEKSELKMEI- 1232
Query: 759 SNTTARRSLTTNSNKLAEERV-KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTL 817
N A T + K E++ + LED++ E++ K E++R L A+ + +
Sbjct: 1233 -NDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEF 1291
Query: 818 IKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSL 877
SR LD D L R Q Q+ L+ + LE + + T LQ ++ L
Sbjct: 1292 --SRQLDEKDAMVSQLSRGKQAFTQQIEELK---RQLEEETKAKSTLAHALQSARHDCDL 1346
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
++ + K +L+ + +A +++ + + + ++ EA KK L+ +
Sbjct: 1347 LREQYEEEQEAK-AELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKP--RIPKKPTDLTTKL-QLKKMVE 994
Q ++ L D ++S + KK + L + K+ E
Sbjct: 1406 EHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYE 1465
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
+ + E+ ++ LS + K E+ +D + + E LQ EI+
Sbjct: 1466 ETQAELEASQ--KESRSLSTELFKVKNAYEESLDHLET--------LKRENKNLQQEISD 1515
Query: 1055 LKDVNAKLEGDKDV--FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
L + A EG K + K L++E S L + +++ E +I ++ +L
Sbjct: 1516 LTEQIA--EGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573
Query: 1113 S-LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEV-GDKTKKI 1170
S + +++ +D + D ++ K++ GD +
Sbjct: 1574 SEIDRKIAE---KDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEME 1630
Query: 1171 GDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK 1230
+ + KD LA RR ++ + +E
Sbjct: 1631 IQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANL-MQAEV 1689
Query: 1231 DELQARFIKTESKFITLEAEMRDLKADYE---NKITSLESTIAAKDVHIKQ----LEDAL 1283
+EL+A +TE E E+ D + + TSL +T + I Q +ED +
Sbjct: 1690 EELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIV 1749
Query: 1284 RQTTN--DKYDEATSPVEMV--EMRXXXXXXXXXXXXXQDELNNAK-IKLEKTEAESSA- 1337
++ N +K +A + M+ E++ ++ K ++L EAE A
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLGEAEQLAL 1809
Query: 1338 --AKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
K ++ +L++ + +LE+ E + KEL + +RK + R++
Sbjct: 1810 KGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQ 1869
Query: 1396 IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLE 1445
DK ++ K + + E+ S + +L+ E EE ++ +
Sbjct: 1870 DLVDK----LQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAEERAD 1915
Score = 72.5 bits (170), Expect = 1e-11
Identities = 208/1095 (18%), Positives = 424/1095 (38%), Gaps = 98/1095 (8%)
Query: 477 ELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPET---VKVSRSSLTRGGSQE 533
E E+E+A E + + ELA+ +K ++ + Q + ++V + ++E
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 534 DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI--VTCDIHE 591
QL++ ++ EA ++E AE+E +++N K+ + D + DI +
Sbjct: 908 RCDQLIKT---KIQLEAKIKEVTERAEDE----EEINAELTAKKRKLEDECSELKKDIDD 960
Query: 592 SETVTNSIQNKMIHAASTPSSKEKSDSPPL--SIDKTTEETQFHFDLPYLSI----FNHM 645
E ++ + HA + L +I K T+E + + ++
Sbjct: 961 LELTLAKVEKEK-HATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEED 1019
Query: 646 AANNLRKTAARVEE---DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
N L K ++E+ D E L Q KK+ K KL+ E+ D
Sbjct: 1020 KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDL-KLAQESTMDT----- 1073
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
E D ++ L+ E E + L+ K+E+ + L+K++KEL ++I + +
Sbjct: 1074 -ENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEE-----EIE 1127
Query: 763 ARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR- 821
A R+ S AE++ L E++E+ ++L E A++ L +K+ K R
Sbjct: 1128 AERA----SRAKAEKQRSDLSRELEEISERL---EEAGGATSAQIELNKKREAEFQKMRR 1180
Query: 822 SLDASDQQNVDLKRQLQVIEQEA-SVLRAKTQSLEADNEKLQTENKKLQLLKN--AKSLR 878
L+ S Q+ L+ ++ + L + SL+ +KL+ E +L++ N A ++
Sbjct: 1181 DLEESTLQHEATAAALRKKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEINDLASNME 1240
Query: 879 SDKALDLNTKKTTQ-LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ N +K + LE++L E K +E + + +E S +K R + + + L K
Sbjct: 1241 TVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLI-NELSAQKARLHTESGEFSRQLDEKD 1299
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKS-LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL 996
+ L+ K + + + + DL + ++
Sbjct: 1300 AMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA 1359
Query: 997 ECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK 1056
E + G + A K T + +E++E + KL++ + + ++ A L+
Sbjct: 1360 ELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLE 1419
Query: 1057 DVNAKLEGD-KDVFANKYK------ALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+L+ + +D+ + + AL+ + N K L E + E +L A K
Sbjct: 1420 KTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD---KVLAEWKQKYEETQAELEASQK 1476
Query: 1110 NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTK-----------IDQDKNK 1158
+ SL T + ++ + T+ +++ K +
Sbjct: 1477 ESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQ 1536
Query: 1159 LLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV----- 1213
L E + + + RI+ +L+ K + Q
Sbjct: 1537 LDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLR 1596
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAA-K 1272
V+ + L E+ S D L+ + K E +E ++ + +L +T K
Sbjct: 1597 VVESMQSTLDAEIRSRNDALRIKK-KMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILK 1655
Query: 1273 DVHIKQLEDALRQTTNDKYDEAT-------SPVEMVEMRXXXXXXXXXXXXXQDELNNA- 1324
D + L+DA+R + K A E+ E+R + EL +A
Sbjct: 1656 DTQL-HLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDAS 1714
Query: 1325 -KIKLEKTEAES---SAAKLE--MAQLKSDLAKL-ENXXXXXXXXXXXXXXXSSYWENKA 1377
+++L T+ S + KLE ++Q++ ++ + + + E
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
KE DT ER K + + D ++ +AE LKG K +++ + +E++ E
Sbjct: 1775 KEQDTSAHLERMKKNMEQTVKDLQLRLGEAEQLALKGGKKQIQKLEARVRELESEVESEQ 1834
Query: 1438 E---ETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKE 1493
+ E VK L +H +++ Y+ + +L + +V K + V+ + Q E +++
Sbjct: 1835 KHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAE--EAEEQ 1892
Query: 1494 LSTALGEIKTLQEKL 1508
+ L + + LQ +L
Sbjct: 1893 SNVNLAKFRKLQHEL 1907
Score = 66.5 bits (155), Expect = 9e-10
Identities = 159/750 (21%), Positives = 283/750 (37%), Gaps = 84/750 (11%)
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K +LE +I E+ + ++++ E E L + KL+D ++L+ D D +E E
Sbjct: 916 KIQLEAKIKEVTER-AEDEEEINAE---LTAKKRKLEDECSELKKDIDDLELTLAKVEKE 971
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXX 1139
N+ K LTEEM + I KL+ + K +LQ +
Sbjct: 972 KHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDDLQMEEDKVNTLTKAK 1028
Query: 1140 XXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVT 1199
QVD+ + + KL ++ +K+ + ++QL+ + +
Sbjct: 1029 TKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKE 1088
Query: 1200 XXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYE 1259
LA ++ EL + +EL+ + E + DL + E
Sbjct: 1089 FEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1148
Query: 1260 NKITSLEST--IAAKDVHIKQLEDALRQTTNDKYDEATSPVE--MVEMRXXXXXXXXXXX 1315
LE + + + + +A Q +E+T E +R
Sbjct: 1149 EISERLEEAGGATSAQIELNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELG 1208
Query: 1316 XXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
D L K KLEK E S K+E+ L S++ + S +
Sbjct: 1209 KQIDSLQRVKQKLEK---EKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKT 1265
Query: 1376 KAKE---LDTDLQSERKKLDRMRIAHDKDVKNKDAELATL-KGKLKILEQNSGAGAKRIT 1431
K +E L +L +++ +L + + KDA ++ L +GK +Q I
Sbjct: 1266 KEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQ--------IE 1317
Query: 1432 ELKQEYEETVK-KLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHV 1490
ELK++ EE K K + AL+ A ++ +LL E++ E+++A+ EL
Sbjct: 1318 ELKRQLEEETKAKSTLAHALQSARHD-----CDLLREQY--------EEEQEAKAEL--- 1361
Query: 1491 QKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD 1550
Q+ +S A E+ + K T+ A TE E++ + L +RL VE +N++
Sbjct: 1362 QRGMSKANSEVAQWRTKYETD-AIQRTE--ELEEAKKKLAQRLQDAEEHVE--AVNSKCA 1416
Query: 1551 QRER-ELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXX 1609
E+ + R N+ D++ + K QR
Sbjct: 1417 SLEKTKQRLQNEVEDLMIDVERSNAACIA-----------LDKKQRNFDKVLAEWKQKYE 1465
Query: 1610 XXXXXIEQSEKARKA---EITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLE 1666
+E S+K ++ E+ K YE + D L++L +RE N +Q +
Sbjct: 1466 ETQAELEASQKESRSLSTELFKVKNAYEESL----DHLETL-------KRENKNLQQEIS 1514
Query: 1667 AAQKSMAEIKNGDKSARIHR-NSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKL 1725
+ +AE G K IH + + E LE+ A LE E E ++L ++
Sbjct: 1515 DLTEQIAE---GGK--HIHELEKVKKQLDHEKSELQTSLEEAEASLEHE--EGKIL--RI 1565
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERL 1755
EL KS + ++AE L++ + L
Sbjct: 1566 QLELNQVKSEIDRKIAEKDEELDQLKRNHL 1595
Score = 64.5 bits (150), Expect = 4e-09
Identities = 170/961 (17%), Positives = 370/961 (38%), Gaps = 76/961 (7%)
Query: 183 KEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGP 242
K EKE K E+ A+ + +R ++ + LMQ KN +L+ V+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKN-----DLQLQVQAEA 899
Query: 243 XXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDI--------LRKRCERVEKEK 294
+++ +KE ++ E ++E++ L C ++K+
Sbjct: 900 DALADAEERCDQLIKTKIQLEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDI 958
Query: 295 SDILLRRLANIDTANKYTTGR----SSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREI 350
D+ L LA ++ T + + E+ L + + +LT + L++ + ++
Sbjct: 959 DDLEL-TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME 1017
Query: 351 ESELETRPSTEAQ-TRQIEQLRAKLLAAETLCEELMDENEDMKKELR-DLXXXXXXMQDN 408
E ++ T + + +Q++ L L + LC +L E K++L DL D
Sbjct: 1018 EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDL----ERAKRKLEGDLKLAQESTMDT 1073
Query: 409 FREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG 468
+ Q ++E E + L K++ + A QL+++ E + ++ E+ +
Sbjct: 1074 ENDKQQLNEKLKKKEFEMS-----NLQGKIEDEQALAMQLQKKIKELQARIEELEEEIEA 1128
Query: 469 MQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTR 528
+R +R K +Q S E+ + L EA T + L K + E K+ R
Sbjct: 1129 -ERASRAKAEKQRSDLSRELE-EISERLEEAGGA-TSAQIELNKKREAEFQKMRRDLEES 1185
Query: 529 GGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD 588
E A LR + + A+L +Q+ + + ++ ++ + N+ T
Sbjct: 1186 TLQHEATAAALR--KKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEINDLASNMETVS 1243
Query: 589 IHES--ETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKT---TEETQFHFDLPYLSIFN 643
++ E + +++++ + T +++ LS K TE +F L
Sbjct: 1244 KAKANFEKMCRTLEDQ-LSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMV 1302
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK-ET 702
+ + ++EE L + K +T A + + S + L + + + K E
Sbjct: 1303 SQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQ-SARHDCDLLREQYEEEQEAKAEL 1361
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ + + T ++ EELE+ K+ L +++++ + +V A T
Sbjct: 1362 QRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 763 ARRSLTTNSNKLAE-ERVKVLEDEIDEVR----KKLIEKERDCERLHAELSLAQKKPKTL 817
+R + + + ER +D+ + K L E ++ E AEL +QK+ ++L
Sbjct: 1422 KQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSL 1481
Query: 818 ------IKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS-----LEADNEKLQTENK 866
+K+ ++ D LKR+ + ++QE S L + E + K Q +++
Sbjct: 1482 STELFKVKNAYEESLDHLET-LKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHE 1540
Query: 867 KLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEAT 926
K +L + + ++ +L+ K +++ EL + ++I +E + K
Sbjct: 1541 KSELQTSLE--EAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVV 1598
Query: 927 KKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTK 986
+ TL ++ + L A ++ + + T+
Sbjct: 1599 ESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQ 1658
Query: 987 LQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKN 1046
L L + + ++ +V + A L ++ E++E+R+ L + + +
Sbjct: 1659 LHLDDAIRGQDDLKEQLAMVERRANL----------MQAEVEELRASLERTE----RGRK 1704
Query: 1047 RLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
+ E+ + L N K LE + S + + + + +E +N E + K
Sbjct: 1705 MAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAIT 1764
Query: 1107 D 1107
D
Sbjct: 1765 D 1765
Score = 58.8 bits (136), Expect = 2e-07
Identities = 115/585 (19%), Positives = 228/585 (38%), Gaps = 49/585 (8%)
Query: 1225 ELTSEKDEL---QARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK---Q 1278
E K+EL +A+ + E K +TL E DL+ + + +L D IK Q
Sbjct: 859 EFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQ 918
Query: 1279 LEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAA 1338
LE +++ T DE E+ + D+L ++ L K E E A
Sbjct: 919 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL---ELTLAKVEKEKHAT 975
Query: 1339 KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAH 1398
+ ++ L ++A L+ + E + LD DLQ E K++ + A
Sbjct: 976 ENKVKNLTEEMAGLDETIAKLTKEK------KALQEAHQQTLD-DLQMEEDKVNTLTKAK 1028
Query: 1399 DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL 1458
K + ++ L+G L EQ + K++ E +K + S + + ++L
Sbjct: 1029 TK----LEQQVDDLEGSL---EQEKKL-CMDLERAKRKLEGDLKLAQESTMDTENDKQQL 1080
Query: 1459 TGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAA---W 1515
K L ++E ++ + +E EQA + +QK++ I+ L+E++ E A+
Sbjct: 1081 NEK--LKKKEFEMSNLQGKIEDEQALA--MQLQKKIKELQARIEELEEEIEAERASRAKA 1136
Query: 1516 NTEKTEMQNSIASLQERL-CGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXX 1574
+++++ + + ERL GG + LN + + +++R + L+H
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQIELNKKREAEFQKMR-RDLEESTLQHEATAAA 1195
Query: 1575 XXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYE 1634
+++ +QR E KA K +E
Sbjct: 1196 LRKKHADSVAELGKQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKA-----KANFE 1250
Query: 1635 GQMNTMRDELKSLHNQVSRFRRERDNYKQMLE-AAQKSMAEIKNGDKSARIHRNSISSTD 1693
T+ D+L + +E + + + E +AQK+ ++G+ S ++ +
Sbjct: 1251 KMCRTLEDQLSEIKT------KEEEQQRLINELSAQKARLHTESGEFSRQLDEK--DAMV 1302
Query: 1694 EEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEE 1752
+ R K A QQ+ L+ +L E S L L S + ++ + + + E
Sbjct: 1303 SQLSRGKQA-FTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAEL 1361
Query: 1753 ERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+R +S + VA T+ E + +E + ++ + +D +
Sbjct: 1362 QRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1406
>AF111782-1|AAD29948.1| 1938|Homo sapiens myosin heavy chain protein.
Length = 1938
Score = 92.7 bits (220), Expect = 1e-17
Identities = 200/1085 (18%), Positives = 414/1085 (38%), Gaps = 76/1085 (7%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
E + A MK E ++E + +ELE+ +L ++ +L ++ S T+ +
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDE---VRKKLIEKERDCERLHAELSL-AQKKPKTLIK 819
+ S L E +VK L + ++E + +L+ K+R+ E + L TL K
Sbjct: 910 EGLI--KSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTK 967
Query: 820 -SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK----LQTENKKLQ-LLK- 872
+ A++ + +L ++ +E+ S L + +SL+ +++ LQ E K+ L+K
Sbjct: 968 VEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKI 1027
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIK-ELEMICQD--EKSEKKVRFTEATKKE 929
NAK + L+ + ++ +L +L+ A K++ +L+M + + +K + E KK+
Sbjct: 1028 NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENEKQQIEEKLKKK 1087
Query: 930 TDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDD--AQKSFKPRIPKKPTDLTTKL 987
L Q QA ++ L+++ A+ + + +I K+ +DL +L
Sbjct: 1088 EFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLAREL 1147
Query: 988 Q-LKKMVEDLECEIGEMYVVMKNAGLSGKEMT-----AKTKLEKEIDEIRSKLSKNDSEF 1041
+ + + +E+ + K ++M A + E +R K + + +E
Sbjct: 1148 EEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAEL 1207
Query: 1042 TNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTE---EMKNRE 1098
+ + LQ KL+ ++L+ + D A+ +AL SN+ C+T+ + E+K ++
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 1099 AQINKLSADLK-NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN 1157
Q +L DL LQT + Q++
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLE---------- 1317
Query: 1158 KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLAN 1217
+L +++ ++TK C + +Q ++ +
Sbjct: 1318 ELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWKT 1377
Query: 1218 THRRLSIELTSEKDE--------LQARFIKTE---SKFITLEAEMRDLKADYENKITSLE 1266
+ +I+ T E +E LQ KTE SK +LE + L+ + E+ + LE
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQEAEEKTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437
Query: 1267 -STIAAKDVHIKQLE-DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNA 1324
S A + KQ D + K DE+ + +E + ++
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE--SRSLSTELFKMRNAYEEV 1495
Query: 1325 KIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL 1384
+LE E+ + E++ L +A+ S + +E++ L
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 1385 QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKL 1444
+ E K+ R+++ + D ++ +++ L++NS A+ L+ + ++
Sbjct: 1556 EHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAE---ALQSVLDAEIRSR 1612
Query: 1445 EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTL 1504
+L L+K +L + E+ A QG+L Q L AL + L
Sbjct: 1613 NDALRLKKKMEGDL-NEMEIQLGHSNRQMAETQRHLRTVQGQLKDSQLHLDDALRSNEDL 1671
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
+E+L E++ +L+ + ER R RL E+EL A+DR
Sbjct: 1672 KEQLAIVERRNGLLLEELEEMKVALE--------QTERTR---RLS--EQELLDASDRVQ 1718
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
+L H + ++++ +E+ +K
Sbjct: 1719 LL--HSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKE 1776
Query: 1625 EITDTKTRYEGQMNTMRDELKSLHNQVSRFRR-ERDNYKQMLEAAQKSMAEIKNGDKSAR 1683
+ DT E + +K L +++ + K+ ++ + + E++N +
Sbjct: 1777 Q--DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELEN-ELDVE 1833
Query: 1684 IHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEM 1743
R + + +Y KV + Q + + L KL ++ S K AE +
Sbjct: 1834 QKRGAEALKGAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQA 1893
Query: 1744 QSRLN 1748
++L+
Sbjct: 1894 NTQLS 1898
Score = 83.0 bits (196), Expect = 1e-14
Identities = 180/1008 (17%), Positives = 410/1008 (40%), Gaps = 80/1008 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
+ +D+ LK+++D L +VEKEK T NK S E+ L++ +
Sbjct: 945 RNLEDKCSSLKRDIDDLELTLTKVEKEKH----------ATENK-VKNLSEEMTALEENI 993
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
++LT EKK L + ++ +L+ E + + ++ AKL E ++L
Sbjct: 994 SKLT-------KEKKSLQEAHQQTLDDLQVE---EDKVNGLIKINAKL---EQQTDDLEG 1040
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
E KK DL ++ + + Q + L E +Q + + F+L + + + D
Sbjct: 1041 SLEQEKKLRADLERAKRKLEGDLKMSQ-ESIMDLENEKQQIEEKLKKKEFELSQLQARID 1099
Query: 447 QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGS 506
+ + +KK+ E+ + RI+ELE+E+ + +++++ ++ +
Sbjct: 1100 DEQVHSLQFQKKIKEL---------QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI 1150
Query: 507 NPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANC 566
+ L + + ++ + Q ++ RDL+ EA L+ + A T
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQ----KMRRDLE-----EATLQHE---ATAATLRK 1198
Query: 567 KQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKT 626
KQ + L +Q+ DN+ + E + ++ ++ AS + KS S +I++T
Sbjct: 1199 KQADSVAELGEQI--DNLQRVK-QKLEKEKSELKMEIDDMASNIEALSKSKS---NIERT 1252
Query: 627 --TEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTP 684
T E QF ++ ++L AR++ N L ++++ ++ +L+ +
Sbjct: 1253 CRTVEDQFS-EIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE--KESLISQLTKSK 1309
Query: 685 PANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKE 744
A +E E+ET + M L+ + + +LR + EE ++ K L++ + +
Sbjct: 1310 QALTQQLEELKRQMEEETKAKN--AMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSK 1367
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLH 804
S+++ KT ++ R + K +R++ E++ + K E+ +RL
Sbjct: 1368 ANSEVAQ-WKTKYETDAIQRTEELEEAKKKLAQRLQEAEEKTETANSKCASLEKTKQRLQ 1426
Query: 805 AEL-SLAQKKPKTLIKSRSLDASDQQNVD---LKRQLQVIEQEASVLRAKTQSLEADNEK 860
E+ L + ++ +LD Q+N D + + ++ E +A + A+ +S E
Sbjct: 1427 GEVEDLMRDLERSHTACATLD-KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEL 1485
Query: 861 LQTENKKLQLLKNAKSL-RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK 919
+ N +++ ++L R +K L T+ E + L + ++ + + + EKS+ +
Sbjct: 1486 FKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQ 1545
Query: 920 VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKK 979
V E ++ LK ++Q++ +
Sbjct: 1546 VALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVL 1605
Query: 980 PTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID-EIR-SKLSKN 1037
++ ++ ++ + +E ++ EM + + G S ++M + + + +++ S+L +
Sbjct: 1606 DAEIRSRNDALRLKKKMEGDLNEMEIQL---GHSNRQMAETQRHLRTVQGQLKDSQLHLD 1662
Query: 1038 DSEFTNEKNRLQTEIAKLKD--VNAKLEGDK---DVFANKYKALENENSNLSNQCKTLTE 1092
D+ +NE + Q I + ++ + +LE K + + E E + S++ + L
Sbjct: 1663 DALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHS 1722
Query: 1093 EMKNREAQINKLSADLKNA-TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTK 1151
+ + KL AD+ ++ ++ + + D
Sbjct: 1723 QNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1782
Query: 1152 IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQ 1211
+++ K L + V D ++ + K+I+K L R + +
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGK--KQIQK-LENRVRELENELDVEQKRGAE 1839
Query: 1212 AVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYE 1259
A+ A+ + R E+T + +E + ++ + L+A+++ K E
Sbjct: 1840 ALKGAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1887
Score = 79.0 bits (186), Expect = 2e-13
Identities = 144/709 (20%), Positives = 299/709 (42%), Gaps = 73/709 (10%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTANKYTT------G 314
+++ +++ D +EG ++ LR ER +++ + D+ + + + +D N+
Sbjct: 1027 INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENEKQQIEEKLKK 1086
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ--------TRQ 366
+ E+ +LQ ++++ H+ + + K L +I E+E E+E + A+ R+
Sbjct: 1087 KEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146
Query: 367 IEQLRAKLLAAETLCEELMDEN-------EDMKKELRDLXXXXXXMQDNFREDQADEYSS 419
+E++ +L A ++ N + M+++L + R+ QAD +
Sbjct: 1147 LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVA- 1205
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENR-IKEL 478
EL + I N + + KL E++ +L+ E + + + ++R R +++
Sbjct: 1206 ---ELGEQIDNLQRVKQKL---EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ 1259
Query: 479 EQEVARSTEVALRLQRELAEANSKFTGSNPSLM-KVPQPETVKVSRSSLTRGGSQEDPAQ 537
E+ E +L +L ++ N L +V + E++ S LT+ S++ Q
Sbjct: 1260 FSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESL---ISQLTK--SKQALTQ 1314
Query: 538 LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
L +L+ +E E + + +A + + + L +Q + ++ + + N
Sbjct: 1315 QLEELKRQMEEETKAKNAMAHALQSSR-----HDCDLLREQYEEEQEAKAELQRALSKAN 1369
Query: 598 S--IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
S Q K + E+ + + + +E + + N A +L KT
Sbjct: 1370 SEVAQWKTKYETDAIQRTEELEEAKKKLAQRLQEAEEKTETA-----NSKCA-SLEKTKQ 1423
Query: 656 RVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLL 714
R++ + E L+ L++ T + +K+ E DE + + EA E + L
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLD-KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL- 1481
Query: 715 ELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
E +R EE+ E L+++ K L +IS +T+ A + + + T KL
Sbjct: 1482 ---STELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKT--KKL 1536
Query: 775 AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKK--PKTLIKSRSLDASDQQNVD 832
E+ L+ ++EV L +E R+ ELS + + K + K ++ + +
Sbjct: 1537 VEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQR 1596
Query: 833 LKRQLQ-VIEQEA----SVLRAKTQSLEAD-NE-KLQTENKKLQLLKNAKSLRSD----K 881
LQ V++ E LR K + +E D NE ++Q + Q+ + + LR+ K
Sbjct: 1597 AAEALQSVLDAEIRSRNDALRLK-KKMEGDLNEMEIQLGHSNRQMAETQRHLRTVQGQLK 1655
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRF--TEATKK 928
L+ + +LKE LA ++ + +E E KV TE T++
Sbjct: 1656 DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRR 1704
Score = 43.6 bits (98), Expect = 0.007
Identities = 96/555 (17%), Positives = 208/555 (37%), Gaps = 42/555 (7%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQ 1285
L + D+L+ K E + E ++++L + +T+LE I+ K L++A +Q
Sbjct: 954 LKRDIDDLELTLTKVEKEKHATENKVKNLSEE----MTALEENISKLTKEKKSLQEAHQQ 1009
Query: 1286 TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDE-------LNNAKIKLE---KTEAES 1335
T +D E ++++ ++ L AK KLE K ES
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQES 1069
Query: 1336 SA-AKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM 1394
+ E Q++ L K E S ++ K KEL ++ ++++
Sbjct: 1070 IMDLENEKQQIEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAE 1129
Query: 1395 RIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ---EYEETVKKLEHSLALE 1451
K K + L+ + LE+ SGA + +I K+ E+++ + LE +
Sbjct: 1130 HTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1189
Query: 1452 KAEYEELTGKY-----ELLEEEHVVTKARLTVEKEQAQ---------GELLHVQKELSTA 1497
+A L K EL E+ + + + +EKE+++ + + K S
Sbjct: 1190 EATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNI 1249
Query: 1498 LGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELR 1557
+T++++ +E A + ++T++ + + + RL + + L+ R++++E +
Sbjct: 1250 ERTCRTVEDQF-SEIKAKDEQQTQLIHDLNMQKARL-----QTQNGELSHRVEEKESLIS 1303
Query: 1558 AANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQ 1617
+ L + + R +++
Sbjct: 1304 QLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 1618 SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN 1677
+ +E+ KT+YE +EL+ ++++ +E + + E A A ++
Sbjct: 1364 ALSKANSEVAQWKTKYETDAIQRTEELEEAKKKLAQRLQEAE---EKTETANSKCASLEK 1420
Query: 1678 GDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAE 1737
+ + + D E A L+++ + L E + + EL + + +
Sbjct: 1421 TKQRLQGEVEDL-MRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESR 1479
Query: 1738 VRLAEMQSRLNEYEE 1752
E+ N YEE
Sbjct: 1480 SLSTELFKMRNAYEE 1494
Score = 39.9 bits (89), Expect = 0.091
Identities = 77/391 (19%), Positives = 157/391 (40%), Gaps = 53/391 (13%)
Query: 153 SQTQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDER 212
S Q+A+ + + E + ++L+ Q + ++ E +R+ + K +E E+ R
Sbjct: 1542 SDLQVALEEVEGSLEH-EESKILRVQLELSQ---VKSELDRKVIEKDEEIEQLKRNSQRA 1597
Query: 213 SSTKDDVNFLMQVKNSRNSTNLKPPVRGG----PXXXXXXXXXXXXXXXXXXLVDSNVKE 268
+ V ++++ ++ LK + G V +K+
Sbjct: 1598 AEALQSV-LDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQRHLRTVQGQLKD 1656
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYT--TGRSSE--VLKLQQ 324
Q ++ + + L+++ VE+ ++ +LL L + A + T T R SE +L
Sbjct: 1657 SQLHLDDALRSNEDLKEQLAIVER-RNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+V L + N L + KK L I + ++E+E S + E+ + + A + EEL
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVEN--SIQESRNAEEKAKKAITDAAMMAEEL 1773
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN-------CRVLSFK 437
KKE +D + +++ LEQT+K+ L+ K
Sbjct: 1774 -------KKE----------------QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1810
Query: 438 -----LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++K E + +LE E +K+ E + G + E ++KE+ + + LRL
Sbjct: 1811 GGKKQIQKLENRVRELENELDVEQKRGAEALKG--AHKYERKVKEMTYQAEEDRKNILRL 1868
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
Q + + +K + + ++SR
Sbjct: 1869 QDLVDKLQAKVKSYKRQAEEAEEQANTQLSR 1899
>M36769-1|AAC17185.1| 1937|Homo sapiens perinatal myosin heavy chain
protein.
Length = 1937
Score = 91.5 bits (217), Expect = 3e-17
Identities = 165/866 (19%), Positives = 345/866 (39%), Gaps = 72/866 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L +E++ R + EK++SD L R L I + G +S ++
Sbjct: 1107 LQKKIKELQARIEELGEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQVE 1165
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETR--PSTEAQTRQIEQLRAKLLAAET 379
L +K + LR + + T + + + L + S QI+ L+ E
Sbjct: 1166 LNKKRE---AEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEK 1222
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
EL E +D+ + ++ R + D+ S L+ + E+ + L+ +
Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGHLEKMCRSLE-DQVSGLKTKEEEQQRLINDLTAQRA 1281
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELA 497
+ + +A + ++ E + + ++ Q E +LE+E +A LQ
Sbjct: 1282 RLQTEAGEYSRQLDEQDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRH 1341
Query: 498 EAN---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD-LR 553
+ + ++ ++ + + S + R + D Q +L+++ ++ A L+
Sbjct: 1342 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1401
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS- 612
E + E A C + + + D ++ D+ S ++ K + S
Sbjct: 1402 EAEEHVEAVNAKCASLEKTKQRLQNEVEDLML--DVERSNAACAALDKKQRNFDKVLSEW 1459
Query: 613 KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
K+K + ++ + +E++ F Y + + LR+ ++++ L
Sbjct: 1460 KQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL--ETLRRAHKNLQQEISDLTE 1517
Query: 667 QLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
Q+ + + K+ K I+ A + E + + +++ LELN+ ++ V
Sbjct: 1518 QIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEV-D 1576
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
RK+ E +++ + LK+ + + S S A R K +E +
Sbjct: 1577 RKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVK------------KKMEGD 1624
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQVIEQE 843
++E+ +L RL AE + + ++K L D + DLK QL ++E+
Sbjct: 1625 LNEMEIQL----NHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERR 1680
Query: 844 ASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
A++L+A+ + L A E+ + E + L + + L + +NTKK +LEN++
Sbjct: 1681 ANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK--KLENDVS 1738
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
+ ++++E+ ++ + + K T+A + LK +Q Q
Sbjct: 1739 QLQSEVEEVIQESRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNLEQTVKDLQ 1797
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
L + A K K +I K L+ V +LE GE+ K + K +
Sbjct: 1798 HRLDEAEQLALKGGKKQIQK----------LEARVRELE---GEVENEQKRNAEAVKGLR 1844
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALEN 1078
+ KE+ + KN + ++LQ ++ K + E + +K++ L++
Sbjct: 1845 KHDRRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQH 1904
Query: 1079 ENSNLSNQCKTLTEEMKNREAQINKL 1104
E + E E+Q+NKL
Sbjct: 1905 E-------LEEAEERADIAESQVNKL 1923
Score = 91.1 bits (216), Expect = 4e-17
Identities = 185/1014 (18%), Positives = 378/1014 (37%), Gaps = 78/1014 (7%)
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
K K L+KS ++++ +K + Q + E + AK + LE L E LQL
Sbjct: 838 KIKPLLKSAE---TEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 894
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+++ D D + ++N++ + AKIKE+ ++E+ E T +K D
Sbjct: 895 QSEA---DSLADAEERCEQLIKNKI-QLEAKIKEVTERAEEEE-EINAELTAKKRKLEDE 949
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KK 991
+ + +K+L ++ I K + + ++
Sbjct: 950 CSELKKDIDDLELTLAKVEKQKHATENKVKNLTEE-MAGLDETIAKLSKEKKALQETHQQ 1008
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
++DL+ E ++ ++ K AKTKLE+++D++ L + +K R+ E
Sbjct: 1009 TLDDLQAEEDKVNILTK----------AKTKLEQQVDDLEGSLEQE------KKLRMDLE 1052
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
AK KLEGD K + ++ N + L E+++ +E +I+ L + +++
Sbjct: 1053 RAK-----RKLEGD-------LKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDE 1100
Query: 1112 TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIG 1171
+++ + + + + K D ++ L+E+ ++ ++ G
Sbjct: 1101 QAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE---KQRSDLSRELEEISERLEEAG 1157
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
KR + R+D L H EL + D
Sbjct: 1158 GATSAQVELNK--KREAEFQKLRRD----LEEATLQHEAMVAALRKKHADSMAELGEQID 1211
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKY 1291
LQ K E + L+ E DL ++ E ++ + + LED + +
Sbjct: 1212 NLQRVKQKLEKEKSELKMETDDLSSNAE----AISKAKGHLEKMCRSLEDQVSGLKTKEE 1267
Query: 1292 DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK 1351
++ ++ R DE + +L +++ S+ E+ + K
Sbjct: 1268 EQQRLINDLTAQRARLQTEAGEYSRQLDEQDALVSQLSRSKQASTQQIEELKHQLEEETK 1327
Query: 1352 LENXXXXXXXXXXXX--XXXSSYWENKA--KELDTDLQSERKKLDRMRIAHDKDVKNKDA 1407
+N Y E + EL L ++ + R ++ D +
Sbjct: 1328 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 1387
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE 1467
EL K KL Q + + + E+T ++L++ + + E L++
Sbjct: 1388 ELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDK 1447
Query: 1468 EHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKLGTESAAWNTEKTE 1521
+ L+ K E+ Q EL QKE LST L ++K + E+ +
Sbjct: 1448 KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRAHKN 1507
Query: 1522 MQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRDV-LEHHHDXXXXXXXX 1579
+Q I+ L E++ GG ++ E ++ +++Q + E++AA + + LEH
Sbjct: 1508 LQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1567
Query: 1580 XXXXXXDYER-VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMN 1638
+ +R +++ ++ ++R + K + EG +N
Sbjct: 1568 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALR-VKKKMEGDLN 1626
Query: 1639 TMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH------RNSISST 1692
M +L + + R N + +L+ Q + + G + + R ++
Sbjct: 1627 EMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQA 1686
Query: 1693 DEEEYRNKVALLEQQVACLEDELCESRLLASKL---NTELVSEKSSAEVRLAEMQSRLNE 1749
+ EE + E+ E EL ++ L NT L++ K E ++++QS + E
Sbjct: 1687 EIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEE 1746
Query: 1750 YEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLLQETSTLARDLRQTL 1799
+E + +A+ A A M KE+D +R+ + +DL+ L
Sbjct: 1747 VIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1800
Score = 79.8 bits (188), Expect = 9e-14
Identities = 160/820 (19%), Positives = 334/820 (40%), Gaps = 70/820 (8%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + ++ + +L +E +EL ++ + KE DL
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV--- 894
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG 465
+ +AD + EQ IKN L K+K+ +A++ E+ AE K ++
Sbjct: 895 -----QSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDE 949
Query: 466 PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETV--KVSR 523
++++ I +LE +A+ + + ++ + G + ++ K+ + + + +
Sbjct: 950 CSELKKD--IDDLELTLAKVEKQKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQ 1007
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
+L ++ED +L + LE++ DL L ++ + ++ D ++ +
Sbjct: 1008 QTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1067
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIF 642
+ + + ++ + + ++ K ++ S E + + + K +E Q + I
Sbjct: 1068 STMDME-NDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIE 1126
Query: 643 NHMAAN-NLRKTAARVEEDNESLLLQLKKM--ATKAR---SRKLSPTPPANKLSIETAND 696
A+ K + + + E + +L++ AT A+ ++K + +E A
Sbjct: 1127 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATL 1186
Query: 697 NDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTS 756
E + EL EQ L+R ++LE++K LK + +L+S +++K +
Sbjct: 1187 QHEAMVAALRKKHADSMAELGEQ-IDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK-A 1244
Query: 757 AGSNTTARRSL--TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
G RSL + K EE + L +++ R +L + + R L ++
Sbjct: 1245 KGHLEKMCRSLEDQVSGLKTKEEEQQRLINDLTAQRARLQTEAGEYSR-----QLDEQDA 1299
Query: 815 KTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD----NEKLQTENKKLQL 870
SRS AS QQ +LK QL+ + + L QS D E+ + E +
Sbjct: 1300 LVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE 1359
Query: 871 LKNAKSLRSDKALDLNTKKTT---QLENELKEALAKIKELEMICQD--EKSEKKVRFTEA 925
L+ A S + + TK T Q EL+EA K+ + ++ E K E
Sbjct: 1360 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEK 1419
Query: 926 TKK----ETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPT 981
TK+ E + L + K ++ Q + K+
Sbjct: 1420 TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS-QKESR 1478
Query: 982 DLTTKL---------------QLKKMVEDLECEIGEMYVVMKNAGLSGKEM-TAKTKLEK 1025
L+T+L L++ ++L+ EI ++ + G E+ K ++E+
Sbjct: 1479 SLSTELFKVKNVYEESLDQLETLRRAHKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ 1538
Query: 1026 EIDEIRSKLSKNDSEFTNEKN---RLQTEIAKLK-DVNAKL-EGDKDV---FANKYKALE 1077
E EI++ L + ++ +E+ R+Q E+ ++K +V+ K+ E D+++ N + +E
Sbjct: 1539 EKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVE 1598
Query: 1078 NENSNLSNQCKTLTEEM---KNREAQINKLSADLKNATSL 1114
S L + ++ + + K E +N++ L +A L
Sbjct: 1599 TMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRL 1638
Score = 61.7 bits (143), Expect = 3e-08
Identities = 177/973 (18%), Positives = 367/973 (37%), Gaps = 77/973 (7%)
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
+D E L +++K ++ + T L A + EK+ + + L+ E
Sbjct: 958 DDLELTLAKVEKQKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEE 1017
Query: 719 QEATVLRRKVEELEQ---DKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT--NSNK 773
+ +L + +LEQ D E +Q K+L + + G A+ S N +
Sbjct: 1018 DKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQ 1077
Query: 774 LAEERVKVLEDEIDEVRKKLIEKERDCE-RLHAELSLAQKKPKTL-----IKSRSLDASD 827
+E+++ E EI + K IE E+ E +L ++ Q + + L + S ++
Sbjct: 1078 QLDEKLEKKEFEISNLISK-IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE 1136
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
+Q DL R+L+ I + T + N+K + E +KL+ +L+ + +
Sbjct: 1137 KQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALR 1196
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
KK EL E + ++ ++ + EKSE K+ ETD L S
Sbjct: 1197 KKHADSMAELGEQIDNLQRVKQKLEKEKSELKM--------ETDDLSSNAEAISKAKGHL 1248
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVM 1007
+ LK+ +++ Q+ ++ T + + +++ + + ++
Sbjct: 1249 EKMCRSLEDQVSGLKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEQDALVSQLSRSK 1308
Query: 1008 KNAGLSGKEMTAKTKLEKEIDEIRS-----KLSKNDSEFTNEKNRLQTE-IAKLKDVNAK 1061
+ + +E+ K +LE+E + + S++D + E+ + E A+L+ +K
Sbjct: 1309 QASTQQIEEL--KHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366
Query: 1062 LEGDKDVFANKYKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQT 1116
+ + KY+ L K L + ++ E + ++A K LQ
Sbjct: 1367 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN 1426
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL------LKEVGDKTKK 1169
+ D M + + K ++ + +L + + + K
Sbjct: 1427 EVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFK 1486
Query: 1170 IGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSE 1229
+ + +R K L +T + + + E+ +
Sbjct: 1487 VKNVYEESLDQLETLRRAHKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAA 1546
Query: 1230 KDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTI-AAKDVHIKQLE------DA 1282
+E +A E K + ++ E+ +K++ + KI + I K H + +E DA
Sbjct: 1547 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDA 1606
Query: 1283 LRQTTNDKYD-EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
++ ND + ++ EM N + L++T+ A
Sbjct: 1607 EIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRG 1666
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSERKKLDRMRIAHD 1399
LK LA +E E K + +L SER +L +
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1726
Query: 1400 KDVKNK-DAELATLKGKL-KILEQNSGA---GAKRITELKQEYEETVKKLEHSLALEKAE 1454
+ K K + +++ L+ ++ ++++++ A K IT+ EE K+ + S LE+ +
Sbjct: 1727 INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1786
Query: 1455 YE-ELTGK---YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTL 1504
E T K + L E E + K +L + +GE+ + QK + A+ ++
Sbjct: 1787 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKH 1846
Query: 1505 QEKLGTESAAWNTEK-----TEMQNSIASLQERLCGGGWEVERA--RLNARLD---QRER 1554
++ + + TE+ +Q+ + LQ ++ + E A + NA L + +
Sbjct: 1847 DRRV--KELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQH 1904
Query: 1555 ELRAANDRRDVLE 1567
EL A +R D+ E
Sbjct: 1905 ELEEAEERADIAE 1917
Score = 60.1 bits (139), Expect = 8e-08
Identities = 171/869 (19%), Positives = 348/869 (40%), Gaps = 76/869 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ +D+ LK+++D L +VEK+K ++ N+ + G + KL ++
Sbjct: 944 RKLEDECSELKKDIDDLELTLAKVEKQK-HATENKVKNL---TEEMAGLDETIAKLSKEK 999
Query: 327 NEL-TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
L TH + L D + E + + T+ T+ + +Q++ L L + L +L
Sbjct: 1000 KALQETHQQTLDD------LQAEEDKVNILTKAKTKLE-QQVDDLEGSLEQEKKLRMDLE 1052
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
++ +L+ M+++ + Q DE ++E E I N L K++ +
Sbjct: 1053 RAKRKLEGDLKLAQESTMDMEND--KQQLDEKLE-KKEFE--ISN---LISKIEDEQAVE 1104
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
QL Q+K + + +E +G +R +R K +Q S E+ + L EA T
Sbjct: 1105 IQL-QKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELE-EISERLEEAGGA-TS 1161
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLEREADLREQLRNAEEET 563
+ L K + E K+ R L Q + A L + DS+ A+L EQ+ N +
Sbjct: 1162 AQVELNKKREAEFQKL-RRDLEEATLQHEAMVAALRKKHADSM---AELGEQIDNLQRVK 1217
Query: 564 ANCKQVNPPTFLDKQVMTDNIVTCDIHES--ETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
++ ++ ++ N + E + S++++ + T +++ L
Sbjct: 1218 QKLEKEKSELKMETDDLSSNAEAISKAKGHLEKMCRSLEDQ-VSGLKTKEEEQQRLINDL 1276
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+ + +T+ L + + + R A ++ E L QL++ TKA++ L+
Sbjct: 1277 TAQRARLQTEAGEYSRQLDEQDALVSQLSRSKQASTQQ-IEELKHQLEE-ETKAKN-ALA 1333
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRK--------VEELEQ 733
+++ + + E+E + AE++ L E R K EELE+
Sbjct: 1334 HALQSSRHDCDLLREQYEEE--QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1391
Query: 734 DKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVKVLEDEIDEVR-- 790
K+ L ++++E + +V A T +R + + + ER +D+ +
Sbjct: 1392 AKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN 1451
Query: 791 --KKLIEKERDCERLHAELSLAQKKPKT----LIKSRSL-DASDQQNVDLKRQLQVIEQE 843
K L E ++ E AEL +QK+ ++ L K +++ + S Q L+R + ++QE
Sbjct: 1452 FDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRAHKNLQQE 1511
Query: 844 AS-----VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
S + Q E + K Q E +K ++ A ++ +L+ K +++ EL
Sbjct: 1512 ISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI--QAALEEAEASLEHEEGKILRIQLELN 1569
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
+ +++ +E + K T + TL ++ +
Sbjct: 1570 QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEME 1629
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
L A +S + + T+L L + E ++ +V + A L
Sbjct: 1630 IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANL------ 1683
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALEN 1078
L+ EI+E+ + L + + + + E+ + L N K LEN
Sbjct: 1684 ----LQAEIEELWATLEQTE----RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLEN 1735
Query: 1079 ENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ S L ++ + + +E +N E + K D
Sbjct: 1736 DVSQLQSEVEEVIQESRNAEEKAKKAITD 1764
>BC126409-1|AAI26410.1| 1941|Homo sapiens myosin, heavy chain 2,
skeletal muscle, adult protein.
Length = 1941
Score = 91.1 bits (216), Expect = 4e-17
Identities = 167/916 (18%), Positives = 363/916 (39%), Gaps = 75/916 (8%)
Query: 187 IEKERERRSLSKSKEDEKTARYKDERSSTK--DDVNF----LMQVKNSRNSTNLKPPVRG 240
I+ E++ L S E EK R ER+ K D+ +M ++N + + K ++
Sbjct: 1031 IKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK--LKK 1088
Query: 241 GPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR 300
+ +KE Q +IE L++E++ R + EK++SD L R
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-LSR 1147
Query: 301 RLANIDTANKYTTGRSSEVLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPS 359
L I + G +S +++ +K E DL E+ L + + S
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATLRKKHADS 1205
Query: 360 TEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEY 417
QI+ L+ E E+ E +D+ + + ++ R EDQ E
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265
Query: 418 SSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG--MQRENRI 475
S E ++ I + L+ + + + ++ + ++ E E + ++ G Q E
Sbjct: 1266 KSKEEEQQRLIND---LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 476 KELEQEVARSTEVALRLQRELAEAN---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ 532
++LE+E+ +A LQ + + ++ S ++ + + + + R +
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEE--ETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
D Q +L+++ ++ L ++L+ AEE E N K + + + D+
Sbjct: 1383 TDAIQRTEELEEAKKK---LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439
Query: 591 ESETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFN 643
+ ++ K + + K+K + ++ + +E + F Y +
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKET 702
+ L++ ++++ L Q+ + + K+ K ++ A + E
Sbjct: 1500 QL--ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL 1557
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ + +++ LELN+ ++ V RK+ E +++ + LK+ + + S S
Sbjct: 1558 EHEEGKILRIQLELNQVKSEV-DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 763 ARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
A R K +E +++E+ +L R+ AE + + ++K
Sbjct: 1617 AIR------------LKKKMEGDLNEMEIQL----NHANRMAAEALRNYRNTQGILKDTQ 1660
Query: 823 LDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAK 875
+ D + DLK QL ++E+ A++L+A+ + L A E+ + E + L + +
Sbjct: 1661 IHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1720
Query: 876 SLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
L + +NTKK +LE ++ + +++++ ++ + + K T+A + LK
Sbjct: 1721 LLHTQNTSLINTKK--KLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMM-AEELKK 1777
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED 995
+Q Q L + A K K +I K + +L+ VE
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR---ELEGEVES 1834
Query: 996 LECEIGEMYVVMKNAGLSGKEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+ E ++ KE+T +T +L+ +D++++K+ + + +
Sbjct: 1835 EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1894
Query: 1048 LQTEIAKLKDVNAKLE 1063
T +AK + + +LE
Sbjct: 1895 SNTNLAKFRKLQHELE 1910
Score = 90.6 bits (215), Expect = 5e-17
Identities = 196/1019 (19%), Positives = 380/1019 (37%), Gaps = 88/1019 (8%)
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
K K L+KS ++++ +K + Q I+ E + AK + LE L E LQL
Sbjct: 841 KIKPLLKSAE---TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
A++ + L ++ QL + AKIKE+ +DE+ E T +K D
Sbjct: 898 QAEA----EGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE-EINAELTAKKRKLEDE 952
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KK 991
+ + +K+L ++ I K + + ++
Sbjct: 953 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE-MAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
++DL+ E ++ + K AK KLE+++D++ L + +K R+ E
Sbjct: 1012 TLDDLQAEEDKVNTLTK----------AKIKLEQQVDDLEGSLEQE------KKLRMDLE 1055
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
AK KLEGD + +ENE L E++K +E +I+ L + +++
Sbjct: 1056 RAK-----RKLEGDLKLAQESIMDIENEKQQLD-------EKLKKKEFEISNLQSKIEDE 1103
Query: 1112 TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIG 1171
+L + + + + K D ++ L+E+ ++ ++ G
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAE---KQRSDLSRELEEISERLEEAG 1160
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
KR + R+D A L H EL + D
Sbjct: 1161 GATSAQIEMNK--KREAEFQKMRRD----LEEATLQHEATAATLRKKHADSVAELGEQID 1214
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK---DVHIKQLEDALRQTTN 1288
LQ + + K LE E ++K + ++ +++E+ AK + + LED L + +
Sbjct: 1215 NLQ----RVKQK---LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 1289 DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
+ ++ ++ R DE +L + + + E+ + +
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE 1327
Query: 1349 LAKLENXXXXXXXXXXXX--XXXSSYWENKAK--ELDTDLQSERKKLDRMRIAHDKDVKN 1404
K +N Y E + EL L ++ + R ++ D
Sbjct: 1328 EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQ 1387
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+ EL K KL Q + + + E+T ++L++ + + E
Sbjct: 1388 RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA 1447
Query: 1465 LEEEHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKLGTESAAWNTE 1518
L+++ L K E+ EL QKE L T L +IK E+ + E
Sbjct: 1448 LDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRE 1507
Query: 1519 KTEMQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRDV-LEHHHDXXXXX 1576
+Q I+ L E++ GG + E ++ +++Q + EL+AA + + LEH
Sbjct: 1508 NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI 1567
Query: 1577 XXXXXXXXXDYER-VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
+ +R +++ ++ ++R I K + EG
Sbjct: 1568 QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR-LKKKMEG 1626
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQ-------KSMAEIKNGDKSARIHRNS 1688
+N M +L + + R N + +L+ Q +S ++K ++ A + R +
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK--EQLAMVERRA 1684
Query: 1689 -ISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKL---NTELVSEKSSAEVRLAEMQ 1744
+ + EE R + E+ E EL ++ L NT L++ K E +++MQ
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 1745 SRLNEYEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLLQETSTLARDLRQTL 1799
+ + +E + +A+ A A M KE+D +R+ + +DL+ L
Sbjct: 1745 GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1803
Score = 82.6 bits (195), Expect = 1e-14
Identities = 232/1189 (19%), Positives = 454/1189 (38%), Gaps = 146/1189 (12%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + ++++ +L +E +EL ++ + KE DL
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAE 900
Query: 406 QDNFR--EDQADEYSSLRRELEQTIKNCRV-----------LSFKLKKTERKADQLEQEK 452
+ E++ D+ + +LE IK L+ K +K E + +L+++
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E +L +E + L
Sbjct: 961 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL-- 1016
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E LR L A+ +
Sbjct: 1017 --QAEEDKVN--TLTKAKIKLE--QQVDDLEGSLEQEKKLRMDLERAKRKLEG------- 1063
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
D ++ ++I+ + +E + + ++ K ++ S E + + + K +E Q
Sbjct: 1064 ---DLKLAQESIMDIE-NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 633 HFDLPYLSIFNHMAAN-NLRKTAARVEEDNESLLLQLKKM--ATKAR---SRKLSPTPPA 686
+ I A+ K + + + E + +L++ AT A+ ++K
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 687 NKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELT 746
+ +E A E + EL EQ + R K ++LE++K +K ++ +L
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK-QKLEKEKSEMKMEIDDLA 1238
Query: 747 SKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAE 806
S + +V+K A+ +L E+ + LED++ E++ K E++R L A+
Sbjct: 1239 SNVETVSK--------AKGNL--------EKMCRTLEDQLSELKSKEEEQQRLINDLTAQ 1282
Query: 807 LSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK 866
Q + SR LD + L R Q A TQ +E +L+ E K
Sbjct: 1283 RGRLQTESGEF--SRQLDEKEALVSQLSRGKQ----------AFTQQIEELKRQLEEEIK 1330
Query: 867 KLQLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEA 925
L +A +S R D DL + Q E E +E+ A+++ E ++ + ++
Sbjct: 1331 AKNALAHALQSSRHD--CDLLRE---QYEEE-QESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT 985
+ T+ L+ + A+L+ T
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---------------------T 1423
Query: 986 KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK 1045
K +L+ VEDL ++ NA + A K ++ D+I ++ + E E
Sbjct: 1424 KQRLQNEVEDLMLDVERT-----NAACA-----ALDKKQRNFDKILAEWKQKCEETHAEL 1473
Query: 1046 NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLS 1105
Q E L K++ + ++ + L+ EN NL + LTE++ +I++L
Sbjct: 1474 EASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE 1533
Query: 1106 ADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGD 1165
K Q C Q++ ++Q K+++ +++ +
Sbjct: 1534 KIKK-----QVEQEKCELQAALEEAEASLEHEEGKILRIQLE----LNQVKSEVDRKIAE 1584
Query: 1166 KTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI 1224
K ++I + ++ ++ +R D + + L N R++
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQL-NHANRMAA 1643
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR 1284
E Q T+ I L+ +R + D + ++ +E I++L L
Sbjct: 1644 EALRNYRNTQGILKDTQ---IHLDDALRS-QEDLKEQLAMVERRANLLQAEIEELRATLE 1699
Query: 1285 QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQD-ELNNAKIKLEKTEAESSAAKLEMA 1343
QT + ++ E Q+ L N K KL E + S + EM
Sbjct: 1700 QTERSR--------KIAEQELLDASERVQLLHTQNTSLINTKKKL---ETDISQMQGEME 1748
Query: 1344 QLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVK 1403
+ + E E KE DT ER K + + D ++
Sbjct: 1749 DILQEARNAEEKAKKAITDAAMMA------EELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 1404 NKDAELATLKGKLKILEQNSGAGAKRITELKQEYE---ETVKKL-EHSLALEKAEYEELT 1459
+AE LKG K +++ + E++ E + E VK L +H +++ Y+
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEE 1862
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ +L + +V K + V+ + Q E +++ +T L + + LQ +L
Sbjct: 1863 DRKNILRLQDLVDKLQAKVKSYKRQAE--EAEEQSNTNLAKFRKLQHEL 1909
Score = 81.4 bits (192), Expect = 3e-14
Identities = 174/1059 (16%), Positives = 401/1059 (37%), Gaps = 70/1059 (6%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
+ E +E AE+ E E + L++ +++LE ++K+ +K+ ++T+ A
Sbjct: 930 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989
Query: 758 GSNTTARRSLTTNSNKLAEERVKVLED-EIDEVRKKLIEKERDCERLHAELSLAQKKPKT 816
G + T + LT L E + L+D + +E + + K A++ L Q+
Sbjct: 990 GLDETIAK-LTKEKKALQEAHQQTLDDLQAEEDKVNTLTK--------AKIKLEQQVDDL 1040
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAK 875
SL+ + +DL+R + +E + + + +E + ++L + KK + + N +
Sbjct: 1041 ---EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQ 1097
Query: 876 S-LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK 934
S + ++AL + QL+ ++KE A+I+ELE + E++ + +A K+ +D +
Sbjct: 1098 SKIEDEQALGI------QLQKKIKELQARIEELEEEIEAERASR----AKAEKQRSDLSR 1147
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE 994
+ K + + QK + T L+K
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMN----KKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1203
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
D E+GE ++ + K K++++ EID+ L+ N + K L+
Sbjct: 1204 DSVAELGEQIDNLQR--VKQKLEKEKSEMKMEIDD----LASNVETVSKAKGNLEKMCRT 1257
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT-S 1113
L+D ++L+ ++ L + L + + ++ +EA +++LS + T
Sbjct: 1258 LEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317
Query: 1114 LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD- 1172
++ + Y + + K +L + + ++
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+ +E+ R+ + L T +RL +E ++
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ----NEVED 1433
Query: 1233 LQARFIKTESKFITLEAEMRD---LKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
L +T + L+ + R+ + A+++ K + + A + L L + N
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKN- 1492
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKI-KLEKTEAESSAAKLEM-AQLKS 1347
Y+E+ +E ++ Q +I +LEK + + K E+ A L+
Sbjct: 1493 AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 1348 DLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK----LDRMRIAHDKDVK 1403
A LE+ S + K E D ++ ++ ++ M+ D +++
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIR 1612
Query: 1404 NKDAEL---ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTG 1460
+++ + ++G L +E + E + Y T L+ + + ++
Sbjct: 1613 SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDT----QIHLDDALR 1668
Query: 1461 KYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNT 1517
E L+E+ + + R L E E+ + L ++ A E+ E++ +T
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV----QLLHT 1724
Query: 1518 EKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXX 1577
+ T + N+ L+ + E+E AR + E+ +A D + E
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEAR-NAEEKAKKAITDAAMMAEELKKEQDTSA 1783
Query: 1578 XXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQM 1637
+ V +Q +E + + E+ + R +
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 1638 NTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEY 1697
+R + + + +R N ++ + K A++K+ + A S+T+ ++
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKF 1902
Query: 1698 R---NKVALLEQQVACLEDELCESRLLASKLNTELVSEK 1733
R +++ E++ E ++ + R+ + +++T+++SE+
Sbjct: 1903 RKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 72.1 bits (169), Expect = 2e-11
Identities = 163/865 (18%), Positives = 334/865 (38%), Gaps = 68/865 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ +D+ LK+++D L +VEKEK T NK + E+ L + +
Sbjct: 947 RKLEDECSELKKDIDDLELTLAKVEKEKH----------ATENK-VKNLTEEMAGLDETI 995
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAETLCEELM 385
+LT + L++ + ++ E ++ T + + +Q++ L L + L M
Sbjct: 996 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL---RM 1052
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
D +K DL + D E Q + ++E E I N L K++ +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE--ISN---LQSKIEDEQALG 1107
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
QL+++ E + ++ E+ + +R +R K +Q S E+ + L EA T
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEA-ERASRAKAEKQRSDLSRELE-EISERLEEAGGA-TS 1164
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ + K + E K+ R E A LR + + A+L EQ+ N +
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR--KKHADSVAELGEQIDNLQRVKQK 1222
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHES--ETVTNSIQNKMIHAASTPSSKEK--SDSPPL 621
++ ++ + N+ T + E + ++++++ S +++ +D
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQ 1282
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
TE +F L + + ++EE L ++K A A + L
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK--AKNALAHALQ 1340
Query: 682 PTPPANKLSIETANDNDEKETD---EADPAEMKLLLELNEQEATVLRRKVEELEQDKEAL 738
+ L E + E + + A ++ + E ++R EELE+ K+ L
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR-TEELEEAKKKL 1399
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVKVLEDEIDEVR----KKL 793
++++ + +V A T +R + + + ER +D+ + K L
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459
Query: 794 IEKERDCERLHAELSLAQKKPKTL------IKSRSLDASDQQNVDLKRQLQVIEQEAS-- 845
E ++ CE HAEL +QK+ ++L IK+ ++ DQ LKR+ + ++QE S
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET-LKRENKNLQQEISDL 1518
Query: 846 ---VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA 902
+ + E + K Q E +K +L A ++ +L+ K +++ EL + +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCEL--QAALEEAEASLEHEEGKILRIQLELNQVKS 1576
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
++ +E + K + TL ++ + L
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
A ++ + + T++ L + E ++ +V + A L
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL---------- 1686
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
L+ EI+E+R+ L + + + + E+ + L N K LE + S
Sbjct: 1687 LQAEIEELRATLEQTE----RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1742
Query: 1083 LSNQCKTLTEEMKNREAQINKLSAD 1107
+ + + + +E +N E + K D
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITD 1767
>AF111784-1|AAD29950.1| 1941|Homo sapiens myosin heavy chain IIa
protein.
Length = 1941
Score = 91.1 bits (216), Expect = 4e-17
Identities = 167/916 (18%), Positives = 363/916 (39%), Gaps = 75/916 (8%)
Query: 187 IEKERERRSLSKSKEDEKTARYKDERSSTK--DDVNF----LMQVKNSRNSTNLKPPVRG 240
I+ E++ L S E EK R ER+ K D+ +M ++N + + K ++
Sbjct: 1031 IKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK--LKK 1088
Query: 241 GPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR 300
+ +KE Q +IE L++E++ R + EK++SD L R
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-LSR 1147
Query: 301 RLANIDTANKYTTGRSSEVLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPS 359
L I + G +S +++ +K E DL E+ L + + S
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATLRKKHADS 1205
Query: 360 TEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEY 417
QI+ L+ E E+ E +D+ + + ++ R EDQ E
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265
Query: 418 SSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG--MQRENRI 475
S E ++ I + L+ + + + ++ + ++ E E + ++ G Q E
Sbjct: 1266 KSKEEEQQRLIND---LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 476 KELEQEVARSTEVALRLQRELAEAN---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ 532
++LE+E+ +A LQ + + ++ S ++ + + + + R +
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEE--ETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
D Q +L+++ ++ L ++L+ AEE E N K + + + D+
Sbjct: 1383 TDAIQRTEELEEAKKK---LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1439
Query: 591 ESETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFN 643
+ ++ K + + K+K + ++ + +E + F Y +
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKET 702
+ L++ ++++ L Q+ + + K+ K ++ A + E
Sbjct: 1500 QL--ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL 1557
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ + +++ LELN+ ++ V RK+ E +++ + LK+ + + S S
Sbjct: 1558 EHEEGKILRIQLELNQVKSEV-DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 763 ARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
A R K +E +++E+ +L R+ AE + + ++K
Sbjct: 1617 AIR------------LKKKMEGDLNEMEIQL----NHANRMAAEALRNYRNTQGILKDTQ 1660
Query: 823 LDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAK 875
+ D + DLK QL ++E+ A++L+A+ + L A E+ + E + L + +
Sbjct: 1661 IHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1720
Query: 876 SLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
L + +NTKK +LE ++ + +++++ ++ + + K T+A + LK
Sbjct: 1721 LLHTQNTSLINTKK--KLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMM-AEELKK 1777
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED 995
+Q Q L + A K K +I K + +L+ VE
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR---ELEGEVES 1834
Query: 996 LECEIGEMYVVMKNAGLSGKEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+ E ++ KE+T +T +L+ +D++++K+ + + +
Sbjct: 1835 EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1894
Query: 1048 LQTEIAKLKDVNAKLE 1063
T +AK + + +LE
Sbjct: 1895 SNTNLAKFRKLQHELE 1910
Score = 90.6 bits (215), Expect = 5e-17
Identities = 196/1019 (19%), Positives = 380/1019 (37%), Gaps = 88/1019 (8%)
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
K K L+KS ++++ +K + Q I+ E + AK + LE L E LQL
Sbjct: 841 KIKPLLKSAE---TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
A++ + L ++ QL + AKIKE+ +DE+ E T +K D
Sbjct: 898 QAEA----EGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE-EINAELTAKKRKLEDE 952
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KK 991
+ + +K+L ++ I K + + ++
Sbjct: 953 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE-MAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
++DL+ E ++ + K AK KLE+++D++ L + +K R+ E
Sbjct: 1012 TLDDLQAEEDKVNTLTK----------AKIKLEQQVDDLEGSLEQE------KKLRMDLE 1055
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
AK KLEGD + +ENE L E++K +E +I+ L + +++
Sbjct: 1056 RAK-----RKLEGDLKLAQESIMDIENEKQQLD-------EKLKKKEFEISNLQSKIEDE 1103
Query: 1112 TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIG 1171
+L + + + + K D ++ L+E+ ++ ++ G
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAE---KQRSDLSRELEEISERLEEAG 1160
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
KR + R+D A L H EL + D
Sbjct: 1161 GATSAQIEMNK--KREAEFQKMRRD----LEEATLQHEATAATLRKKHADSVAELGEQID 1214
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK---DVHIKQLEDALRQTTN 1288
LQ + + K LE E ++K + ++ +++E+ AK + + LED L + +
Sbjct: 1215 NLQ----RVKQK---LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 1289 DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
+ ++ ++ R DE +L + + + E+ + +
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE 1327
Query: 1349 LAKLENXXXXXXXXXXXX--XXXSSYWENKAK--ELDTDLQSERKKLDRMRIAHDKDVKN 1404
K +N Y E + EL L ++ + R ++ D
Sbjct: 1328 EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQ 1387
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+ EL K KL Q + + + E+T ++L++ + + E
Sbjct: 1388 RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA 1447
Query: 1465 LEEEHVVTKARLTVEK---EQAQGELLHVQKE---LSTALGEIKTLQEKLGTESAAWNTE 1518
L+++ L K E+ EL QKE L T L +IK E+ + E
Sbjct: 1448 LDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRE 1507
Query: 1519 KTEMQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAANDRRDV-LEHHHDXXXXX 1576
+Q I+ L E++ GG + E ++ +++Q + EL+AA + + LEH
Sbjct: 1508 NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI 1567
Query: 1577 XXXXXXXXXDYER-VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
+ +R +++ ++ ++R I K + EG
Sbjct: 1568 QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR-LKKKMEG 1626
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQ-------KSMAEIKNGDKSARIHRNS 1688
+N M +L + + R N + +L+ Q +S ++K ++ A + R +
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK--EQLAMVERRA 1684
Query: 1689 -ISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKL---NTELVSEKSSAEVRLAEMQ 1744
+ + EE R + E+ E EL ++ L NT L++ K E +++MQ
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 1745 SRLNEYEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLLQETSTLARDLRQTL 1799
+ + +E + +A+ A A M KE+D +R+ + +DL+ L
Sbjct: 1745 GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1803
Score = 82.6 bits (195), Expect = 1e-14
Identities = 232/1189 (19%), Positives = 454/1189 (38%), Gaps = 146/1189 (12%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + ++++ +L +E +EL ++ + KE DL
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAE 900
Query: 406 QDNFR--EDQADEYSSLRRELEQTIKNCRV-----------LSFKLKKTERKADQLEQEK 452
+ E++ D+ + +LE IK L+ K +K E + +L+++
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E +L +E + L
Sbjct: 961 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL-- 1016
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E LR L A+ +
Sbjct: 1017 --QAEEDKVN--TLTKAKIKLE--QQVDDLEGSLEQEKKLRMDLERAKRKLEG------- 1063
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
D ++ ++I+ + +E + + ++ K ++ S E + + + K +E Q
Sbjct: 1064 ---DLKLAQESIMDIE-NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 633 HFDLPYLSIFNHMAAN-NLRKTAARVEEDNESLLLQLKKM--ATKAR---SRKLSPTPPA 686
+ I A+ K + + + E + +L++ AT A+ ++K
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 687 NKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELT 746
+ +E A E + EL EQ + R K ++LE++K +K ++ +L
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK-QKLEKEKSEMKMEIDDLA 1238
Query: 747 SKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAE 806
S + +V+K A+ +L E+ + LED++ E++ K E++R L A+
Sbjct: 1239 SNVETVSK--------AKGNL--------EKMCRTLEDQLSELKSKEEEQQRLINDLTAQ 1282
Query: 807 LSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK 866
Q + SR LD + L R Q A TQ +E +L+ E K
Sbjct: 1283 RGRLQTESGEF--SRQLDEKEALVSQLSRGKQ----------AFTQQIEELKRQLEEEIK 1330
Query: 867 KLQLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEA 925
L +A +S R D DL + Q E E +E+ A+++ E ++ + ++
Sbjct: 1331 AKNALAHALQSSRHD--CDLLRE---QYEEE-QESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT 985
+ T+ L+ + A+L+ T
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---------------------T 1423
Query: 986 KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK 1045
K +L+ VEDL ++ NA + A K ++ D+I ++ + E E
Sbjct: 1424 KQRLQNEVEDLMLDVERT-----NAACA-----ALDKKQRNFDKILAEWKQKCEETHAEL 1473
Query: 1046 NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLS 1105
Q E L K++ + ++ + L+ EN NL + LTE++ +I++L
Sbjct: 1474 EASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE 1533
Query: 1106 ADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGD 1165
K Q C Q++ ++Q K+++ +++ +
Sbjct: 1534 KIKK-----QVEQEKCELQAALEEAEASLEHEEGKILRIQLE----LNQVKSEVDRKIAE 1584
Query: 1166 KTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI 1224
K ++I + ++ ++ +R D + + L N R++
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQL-NHANRMAA 1643
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR 1284
E Q T+ I L+ +R + D + ++ +E I++L L
Sbjct: 1644 EALRNYRNTQGILKDTQ---IHLDDALRS-QEDLKEQLAMVERRANLLQAEIEELRATLE 1699
Query: 1285 QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQD-ELNNAKIKLEKTEAESSAAKLEMA 1343
QT + ++ E Q+ L N K KL E + S + EM
Sbjct: 1700 QTERSR--------KIAEQELLDASERVQLLHTQNTSLINTKKKL---ETDISQMQGEME 1748
Query: 1344 QLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVK 1403
+ + E E KE DT ER K + + D ++
Sbjct: 1749 DILQEARNAEEKAKKAITDAAMMA------EELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 1404 NKDAELATLKGKLKILEQNSGAGAKRITELKQEYE---ETVKKL-EHSLALEKAEYEELT 1459
+AE LKG K +++ + E++ E + E VK L +H +++ Y+
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEE 1862
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ +L + +V K + V+ + Q E +++ +T L + + LQ +L
Sbjct: 1863 DRKNILRLQDLVDKLQAKVKSYKRQAE--EAEEQSNTNLAKFRKLQHEL 1909
Score = 81.4 bits (192), Expect = 3e-14
Identities = 174/1059 (16%), Positives = 401/1059 (37%), Gaps = 70/1059 (6%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
+ E +E AE+ E E + L++ +++LE ++K+ +K+ ++T+ A
Sbjct: 930 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989
Query: 758 GSNTTARRSLTTNSNKLAEERVKVLED-EIDEVRKKLIEKERDCERLHAELSLAQKKPKT 816
G + T + LT L E + L+D + +E + + K A++ L Q+
Sbjct: 990 GLDETIAK-LTKEKKALQEAHQQTLDDLQAEEDKVNTLTK--------AKIKLEQQVDDL 1040
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAK 875
SL+ + +DL+R + +E + + + +E + ++L + KK + + N +
Sbjct: 1041 ---EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQ 1097
Query: 876 S-LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK 934
S + ++AL + QL+ ++KE A+I+ELE + E++ + +A K+ +D +
Sbjct: 1098 SKIEDEQALGI------QLQKKIKELQARIEELEEEIEAERASR----AKAEKQRSDLSR 1147
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE 994
+ K + + QK + T L+K
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMN----KKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1203
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
D E+GE ++ + K K++++ EID+ L+ N + K L+
Sbjct: 1204 DSVAELGEQIDNLQR--VKQKLEKEKSEMKMEIDD----LASNVETVSKAKGNLEKMCRT 1257
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT-S 1113
L+D ++L+ ++ L + L + + ++ +EA +++LS + T
Sbjct: 1258 LEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQ 1317
Query: 1114 LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD- 1172
++ + Y + + K +L + + ++
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+ +E+ R+ + L T +RL +E ++
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ----NEVED 1433
Query: 1233 LQARFIKTESKFITLEAEMRD---LKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
L +T + L+ + R+ + A+++ K + + A + L L + N
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKN- 1492
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKI-KLEKTEAESSAAKLEM-AQLKS 1347
Y+E+ +E ++ Q +I +LEK + + K E+ A L+
Sbjct: 1493 AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 1348 DLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK----LDRMRIAHDKDVK 1403
A LE+ S + K E D ++ ++ ++ M+ D +++
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIR 1612
Query: 1404 NKDAEL---ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTG 1460
+++ + ++G L +E + E + Y T L+ + + ++
Sbjct: 1613 SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDT----QIHLDDALR 1668
Query: 1461 KYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNT 1517
E L+E+ + + R L E E+ + L ++ A E+ E++ +T
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV----QLLHT 1724
Query: 1518 EKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXX 1577
+ T + N+ L+ + E+E AR + E+ +A D + E
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEAR-NAEEKAKKAITDAAMMAEELKKEQDTSA 1783
Query: 1578 XXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQM 1637
+ V +Q +E + + E+ + R +
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 1638 NTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEY 1697
+R + + + +R N ++ + K A++K+ + A S+T+ ++
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE-EAEEQSNTNLAKF 1902
Query: 1698 R---NKVALLEQQVACLEDELCESRLLASKLNTELVSEK 1733
R +++ E++ E ++ + R+ + +++T+++SE+
Sbjct: 1903 RKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 72.1 bits (169), Expect = 2e-11
Identities = 163/865 (18%), Positives = 334/865 (38%), Gaps = 68/865 (7%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ +D+ LK+++D L +VEKEK T NK + E+ L + +
Sbjct: 947 RKLEDECSELKKDIDDLELTLAKVEKEKH----------ATENK-VKNLTEEMAGLDETI 995
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAETLCEELM 385
+LT + L++ + ++ E ++ T + + +Q++ L L + L M
Sbjct: 996 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL---RM 1052
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
D +K DL + D E Q + ++E E I N L K++ +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFE--ISN---LQSKIEDEQALG 1107
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
QL+++ E + ++ E+ + +R +R K +Q S E+ + L EA T
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEA-ERASRAKAEKQRSDLSRELE-EISERLEEAGGA-TS 1164
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ + K + E K+ R E A LR + + A+L EQ+ N +
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR--KKHADSVAELGEQIDNLQRVKQK 1222
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHES--ETVTNSIQNKMIHAASTPSSKEK--SDSPPL 621
++ ++ + N+ T + E + ++++++ S +++ +D
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQ 1282
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
TE +F L + + ++EE L ++K A A + L
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK--AKNALAHALQ 1340
Query: 682 PTPPANKLSIETANDNDEKETD---EADPAEMKLLLELNEQEATVLRRKVEELEQDKEAL 738
+ L E + E + + A ++ + E ++R EELE+ K+ L
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR-TEELEEAKKKL 1399
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVKVLEDEIDEVR----KKL 793
++++ + +V A T +R + + + ER +D+ + K L
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459
Query: 794 IEKERDCERLHAELSLAQKKPKTL------IKSRSLDASDQQNVDLKRQLQVIEQEAS-- 845
E ++ CE HAEL +QK+ ++L IK+ ++ DQ LKR+ + ++QE S
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET-LKRENKNLQQEISDL 1518
Query: 846 ---VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA 902
+ + E + K Q E +K +L A ++ +L+ K +++ EL + +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCEL--QAALEEAEASLEHEEGKILRIQLELNQVKS 1576
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
++ +E + K + TL ++ + L
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
A ++ + + T++ L + E ++ +V + A L
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL---------- 1686
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
L+ EI+E+R+ L + + + + E+ + L N K LE + S
Sbjct: 1687 LQAEIEELRATLEQTE----RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1742
Query: 1083 LSNQCKTLTEEMKNREAQINKLSAD 1107
+ + + + +E +N E + K D
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITD 1767
>L40157-1|AAA79121.1| 1410|Homo sapiens endosome-associated protein
protein.
Length = 1410
Score = 90.6 bits (215), Expect = 5e-17
Identities = 173/876 (19%), Positives = 353/876 (40%), Gaps = 74/876 (8%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVE----KEKSDILLRRLANIDTANKYTTGRSSEV 319
+ ++E Q+ +E + +++ ++ + +E K K +I L D K G
Sbjct: 502 AKLREAQNDLEQVLRQIGEKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIR-EIESELETRPSTEAQTR-QIEQLRA---KL 374
+ +N+L N L+DE LT+ ++ + ES + + + Q + Q LRA ++
Sbjct: 562 V-----LNQLQEKNHTLQDEVTQLTENVKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR-V 433
L+ ET EL + + K+++ L + +A + ++ R +L+ + +
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK-TAQRADLQNHLDTAQNA 675
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L K ++ + QL+Q A+ + K Q E+ +KE +++ ++L +
Sbjct: 676 LQDKHQELNKITTQLDQVTAKLQDKQEHC------SQLESHLKEYKEKY-----LSLEQK 724
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA-QLLRDLQDSLEREADL 552
E E K ++ +K + + ++ + E A +L + L+ E +
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
R L+ E + KQ +KQ++ + T + + + + N I T
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFET--LSQETKIQHEELNNRIQTTVTELQ 842
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
K K + L + +T + + L +K A + D E +LK
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL-DLEKTCKELKHQL 901
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-----LELNEQEATVLRRK 727
L K S+E + + E + + +L+ L+ NE+E L+
Sbjct: 902 QVQMENTLKEQKELKK-SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDE 785
+ EL+Q E KKQ++ L ++ ++ LT + +LA +E++ VL++
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
++ ++ + + D +EL ++ K++ + SL D + + Q+ Q
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL----ISNRNQIGNQNKL 1076
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
+ KT + + + E + + K + ++ +K+L K +L NE K LA+I+
Sbjct: 1077 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL-----KEKELVNE-KSKLAEIE 1130
Query: 906 ELEMICQDEK------SEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
E++ C+ EK E K E+ K+ T+ +KQ +
Sbjct: 1131 EIK--CRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ 1188
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTA 1019
++ Q+ K ++ K+ +L K + + L EI E V MK K
Sbjct: 1189 EKRN-----QQILKDQVKKEEEEL--KKEFIEKEAKLHSEIKEKEVGMK------KHEEN 1235
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
+ KL +I + L E+ + + R+ +E+ K D L G+ V + ++E
Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRV-SELEKQTD---DLRGEIAVLEATVQNNQDE 1291
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
L +C E++ + ++ +L L N T++Q
Sbjct: 1292 RRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAVQ 1327
Score = 89.8 bits (213), Expect = 9e-17
Identities = 208/1061 (19%), Positives = 411/1061 (38%), Gaps = 85/1061 (8%)
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
Q T++ E E++ E LK + K+ S+ +S T S + S ++ +
Sbjct: 232 QVQTLMDNMTLERERESEKLKDESKKFESQYASSEATI--SQLRSELSKGPQEVRVYVQE 289
Query: 779 VKVLEDEIDEVRKK-------LIEKERDCERL---HAELSLAQKKPKTLIKSRSLDASDQ 828
++ L+ ++E+ +K L++KE+D +L H E S+++K + + + LD
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 829 QN--VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAKSLRSDKALDL 885
Q+ + L I E S TQ L+ + +++T+ + L+ K + R +K
Sbjct: 350 QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE--- 406
Query: 886 NTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXX 945
+ QL++E+ + +K+ E E + E R E + ++ L K+
Sbjct: 407 --QHGLQLQSEINQLHSKLLETER----QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL 460
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC---EIGE 1002
L+ K+ + ++ +T +L++ DLE +IGE
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGE 520
Query: 1003 MYVVMKNA-GLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
++N L K + LEKE +++ +K+ + E T N+LQ + L+D +
Sbjct: 521 KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE-TAVLNQLQEKNHTLQDEVTQ 579
Query: 1062 L-EGDKDVFANKYKALENENSNLSNQ---CKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
L E K+ + +A EN + + Q + + + + E +N+L++ L N + + +
Sbjct: 580 LTENVKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL-NESKEKVS 638
Query: 1118 MSDCMXXXXXXXXXXXXXXXXXXXXXXQ--VDNYTKIDQDKNKLLKEVGDKTKKIGDXXX 1175
D Q +D QDK++ L ++ T ++
Sbjct: 639 QLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKHQELNKI---TTQLDQVTA 695
Query: 1176 XXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQA 1235
C ++E L K++ Q L S+E+ + K++
Sbjct: 696 KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD----SLEVKASKEQALQ 751
Query: 1236 RFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEAT 1295
+ LE +L E + + ST + LE ++ T K +E
Sbjct: 752 DLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT--KQEE-- 807
Query: 1296 SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENX 1355
E ++ +ELNN +++ T E K+E L ++L+ +++
Sbjct: 808 ---EKQILKQDFETLSQETKIQHEELNN---RIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 1356 XXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGK 1415
K K DL+ K+L H V+ ++ L K
Sbjct: 862 LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK-----HQLQVQMENT-LKEQKEL 915
Query: 1416 LKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKAR 1475
K LE+ A + EL E+ ++ +++L + E ++L G L++ K +
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQA-QNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974
Query: 1476 LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQE---R 1532
+ E QGEL + + +++ + E AA + + +QN+ QE +
Sbjct: 975 I----EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 1533 LCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXX----XXXXXXDYE 1588
L + E L R D + E + + + D++ + + + +
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1090
Query: 1589 RVSKIQRXXXXXXXXXXXXXXXXXXXIEQ-SEKARKAEITDTKTRYEGQMNTMRDELKSL 1647
K Q+ E +EK++ AEI + K R E ++ + +ELKS
Sbjct: 1091 SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS- 1149
Query: 1648 HNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ 1707
H S +E N K + + E++ +S+ + E+E RN+ +L+ Q
Sbjct: 1150 HKLES--IKEITNLKDAKQLLIQQKLELQG-------KADSLKAAVEQEKRNQ-QILKDQ 1199
Query: 1708 VACLEDELCESRL-LASKLNTELVSEKSSAEVRLAEMQSRL 1747
V E+EL + + +KL++E + EK + E +++L
Sbjct: 1200 VKKEEEELKKEFIEKEAKLHSE-IKEKEVGMKKHEENEAKL 1239
Score = 89.4 bits (212), Expect = 1e-16
Identities = 216/1145 (18%), Positives = 440/1145 (38%), Gaps = 92/1145 (8%)
Query: 415 DEYSSLRRE---LEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR 471
D+ + LR+E L+ ++K + S +LKK K L+Q++A+ PDG+
Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK-----------PDGLVT 131
Query: 472 EN--RIKELEQEV--ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLT 527
++ ++ LEQ++ A++ ++ ++L E + + + +K E RS
Sbjct: 132 DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE----ERS--L 185
Query: 528 RGGSQEDPAQLLRDLQDSLEREADLREQL--RNAEEETANCKQVNPPTFLDKQVMTDNIV 585
R +++ +L +L DL+ +L R E+ A K+ + Q + DN+
Sbjct: 186 REAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKK----ELVQVQTLMDNMT 241
Query: 586 TCDIHESETVTNSIQNKMIHAASTPSS----KEKSDSPPLSIDKTTEETQ-FHFDLPYLS 640
ESE + + + AS+ ++ + + P + +E Q + L+
Sbjct: 242 LERERESEKLKDESKKFESQYASSEATISQLRSELSKGPQEVRVYVQELQKLKSSVNELT 301
Query: 641 IFNHMAANNLRKTA---ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSI-ETAND 696
N NL K ++EE + + K + + L ++LS ET+
Sbjct: 302 QKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH 361
Query: 697 NDEKETDEADPAEMKLLLELNEQEATVLRRKVE--ELEQDKEALKKQVKELTSKISSVTK 754
E E A KL EL+E E K E +L+Q +E ++ +L S+I+ +
Sbjct: 362 RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS 421
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
+ R L +L E+R ++ +++ + +++ + + RL +L +K
Sbjct: 422 KLLETE----RQLGEAHGRLKEQR-QLSSEKLMDKEQQVADLQLKLSRLEEQLK--EKVT 474
Query: 815 KTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK-LQTENKKLQLLKN 873
+ LD + QQ+ ++ Q ++Q + AK + + D E+ L+ +K Q ++N
Sbjct: 475 NSTELQHQLDKTKQQH----QEQQALQQSTT---AKLREAQNDLEQVLRQIGEKDQKIQN 527
Query: 874 AKSLRSDKALDLNTKKTTQLENELKEALAKIK--ELEMICQDEKSEKKVRFTEATKKETD 931
++L L + + + LE E ++ AKI+ E E ++ EK + + T+
Sbjct: 528 LEAL-----LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQDEVTQLTE 582
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLK 990
+K++ +A L++ +D + +L ++L + K
Sbjct: 583 NVKNQSESHKQAQENLHDQVQEQ---KAHLRAAQDRVLS-----LETSVNELNSQLNESK 634
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ V L+ +I ++ +A + + L+ +D ++ L E +L
Sbjct: 635 EKVSQLDIQIKAKTELLLSA--EAAKTAQRADLQNHLDTAQNALQDKHQELNKITTQLDQ 692
Query: 1051 EIAKLKDVN---AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
AKL+D ++LE + KY +LE + L Q K L + +A + D
Sbjct: 693 VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKT 1167
L+ L T + + ++ K KL K+ +K
Sbjct: 753 LQQQRQLNTDLE--LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
Query: 1168 KKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELT 1227
D + + ++ T + + + + ++S L
Sbjct: 811 ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870
Query: 1228 SEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTT 1287
+ K E + K ++ + LE ++LK + +E+T+ + K LE +
Sbjct: 871 NSKSEFEKENQKGKAAILDLEKTCKELKHQLQ---VQMENTLKEQKELKKSLEKEKEASH 927
Query: 1288 NDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKS 1347
K + + ++++ + Q +N K E+ + + A + E+
Sbjct: 928 QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987
Query: 1348 DLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDA 1407
+LEN KE + LQ+ +K D +++
Sbjct: 988 QKTELENKLQQQLTQAAQELAAE-------KEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE 1467
EL + LK +E+ + + + + KL L KA E+ + K E +
Sbjct: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ-NKLIQELKTAKATLEQDSAKKEQQLQ 1099
Query: 1468 EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE-SAAWNTEKTEMQNSI 1526
E + EK + EL++ + +L+ + EIK QEK T+ + + K E I
Sbjct: 1100 ERCKALQDIQKEKSLKEKELVNEKSKLA-EIEEIKCRQEKEITKLNEELKSHKLESIKEI 1158
Query: 1527 ASLQE 1531
+L++
Sbjct: 1159 TNLKD 1163
Score = 84.2 bits (199), Expect = 4e-15
Identities = 241/1340 (17%), Positives = 511/1340 (38%), Gaps = 94/1340 (7%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKY-------TTGR 315
+SN+ +D + L+QEV L+ + EK S+ L + L + T
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
Query: 316 SSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
S+E+ L+Q++ E T N +++ K QK ++ +E+ S + R + + + +
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 376 AAETLCEELMDEN---EDMKKELRD---LXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
L EEL E +D+K EL + ++ + + +L RE E
Sbjct: 194 T--RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEV 488
F+ + +A + Q ++E K E+ +Q+ ++ + EL Q+ TE
Sbjct: 252 KDESKKFESQYASSEA-TISQLRSELSKGPQEVRVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 489 ALRLQRE---LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
L+ +++ L E +++ + S ++ + + + S+ ++ +L +
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
E L+E+L E + + K F Q + + + ++ N + +K++
Sbjct: 371 GEATQKLKEELSEVETKYQHLK----AEFKQLQQQREEKEQHGL-QLQSEINQLHSKLLE 425
Query: 606 AAST--PSSKEKSDSPPLSIDKTTEETQFHFDLPY-LSIFNHMAANNL-RKTAARVEEDN 661
+ + LS +K ++ Q DL LS + T + + D
Sbjct: 426 TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK 485
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK-ETDEADPAEMKLLLELNEQE 720
Q ++ ++ + KL + + + D+K + EA + K + L E+E
Sbjct: 486 TKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGEKDQKIQNLEALLQKSKENISLLEKE 545
Query: 721 ATVLRRKVE----------ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L K++ +L++ L+ +V +LT + + +++ + +
Sbjct: 546 REDLYAKIQAGEGETAVLNQLQEKNHTLQDEVTQLTENVKNQSESHKQAQENLHDQVQEQ 605
Query: 771 SNKL--AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
L A++RV LE ++E+ +L E + +L ++ + + +++ +D
Sbjct: 606 KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADL 665
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
QN L ++ + L T L+ KLQ + + L++ +K L L +
Sbjct: 666 QN-HLDTAQNALQDKHQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE-Q 723
Query: 889 KTTQLENELKEALAKIKEL----EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
KT +LE ++K+ A E+ E QD + ++++ T+ + T+ K +
Sbjct: 724 KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN-TDLELRATELSKQLEMEKEIVS 782
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
++ + L ++ + + TK+Q +++ ++ + E+
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQ 842
Query: 1005 -VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR-----LQTEIAKLK-D 1057
V M+ L + T K KL K D +++ SK++ E N+K + L+ +LK
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKN--SKSEFEKENQKGKAAILDLEKTCKELKHQ 900
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQI-NKLSADLKNATSLQT 1116
+ ++E K+LE E S+Q K M+ + Q N L + K LQ
Sbjct: 901 LQVQMENTLKEQKELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQG 959
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQ-VDNYTKIDQDKNKLLKEVGDKTKKIGDXXX 1175
+++ Q + K+ Q + +E+ + +KI
Sbjct: 960 NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019
Query: 1176 XXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQA 1235
K+++ R+ + L + +LS+ +++D +
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQD----------LKSVEEKLSL---AQEDLISN 1066
Query: 1236 R-FIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEA 1294
R I ++K I E++ KA E E + + K L+D ++ + + +
Sbjct: 1067 RNQIGNQNKLI---QELKTAKATLEQDSAKKEQQLQER---CKALQDIQKEKSLKEKELV 1120
Query: 1295 TSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL-AKLE 1353
++ E+ +EL + K++ K AK + Q K +L K +
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180
Query: 1354 NXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLK 1413
+ + + +EL + + KL + +K + A L
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 1414 GKLKILEQNSGAGAKRITELKQ---EYEETVKKLEHSLALEKAEYEELTGKYELLEEEHV 1470
++ L +N G K ++ E E+ L +A+ +A + + L E +
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCL 1300
Query: 1471 VTKARLTVEKEQAQGELLHVQKEL--STALGEIKTLQEKLGTESAAWNTEKTEMQNSIAS 1528
+ E E+ Q ++L +Q++L +TA+ E+ + L + K N + +
Sbjct: 1301 KGEG----EIEKLQTKVLELQRKLDNTTAVQELGRENQSLQIKHTQALNRKWAEDNEVQN 1356
Query: 1529 LQERLCGGGWEVERARLNAR 1548
CG G+ V R + R
Sbjct: 1357 CM--ACGKGFSVTVRRHHCR 1374
Score = 80.2 bits (189), Expect = 7e-14
Identities = 241/1303 (18%), Positives = 512/1303 (39%), Gaps = 115/1303 (8%)
Query: 306 DTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR 365
D N G S + + V L +DL+ K E++ ELE + Q
Sbjct: 65 DAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEA 124
Query: 366 QIEQL----RAKLLAAETLCEELMDENEDMK--KELRDLXXXXXXMQDNFREDQADEYSS 419
+ + L A+L + E EE EN ++K K+L + + + + DE S
Sbjct: 125 KPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERS 184
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELE 479
LR EQ + L+ +L K +A ++ K E LL+ G D + + +++
Sbjct: 185 LREAAEQKVTR---LTEELNK---EATVIQDLKTE----LLQRPGIEDVAVLKKELVQVQ 234
Query: 480 QEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL 539
+ T R +L + + KF S T+ RS L++G ++ +
Sbjct: 235 TLMDNMTLERERESEKLKDESKKFESQYAS-----SEATISQLRSELSKG--PQEVRVYV 287
Query: 540 RDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSI 599
++LQ +L+++ E Q L K+ D + H E+V+
Sbjct: 288 QELQ-----------KLKSSVNELTQKNQTLTENLLKKE--QDYTKLEEKHNEESVSKKN 334
Query: 600 QNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE 659
+H ++ D L + ET H LS A L++ + VE
Sbjct: 335 IQATLH-------QKDLDCQQLQSRLSASETSLHRIHVELSEKGE-ATQKLKEELSEVET 386
Query: 660 DNESLLLQLKKMATKARSRKLSPTPPANKLS-IETANDNDEKETDEADPAEMKLLLELNE 718
+ L + K++ + ++ ++++ + + E++ EA +K +L+
Sbjct: 387 KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH-GRLKEQRQLSS 445
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNS-NKLAEE 777
++ ++V +L+ L++Q+KE K+++ T+ + T ++ + +
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKE---KVTNSTELQHQLDKTKQQHQEQQALQQSTTA 502
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS-----LDASDQQNV- 831
+++ ++++++V +++ EK++ + L A L +++ L K R + A + +
Sbjct: 503 KLREAQNDLEQVLRQIGEKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 832 --DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS--DKALDLNT 887
L+ + ++ E + L ++ ++++ K EN Q+ + LR+ D+ L L T
Sbjct: 563 LNQLQEKNHTLQDEVTQLTENVKN-QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEA-TKKETDT---LKSKQXXXXXX 943
+L ++L E+ K+ +L++ + K+E + A T + D L + Q
Sbjct: 622 S-VNELNSQLNESKEKVSQLDIQIK-AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQK--SFKPRIPKKPTDLTTKLQ-LKKMVEDLECEI 1000
A L+ ++ + S +K L K + L+ ++ LE +
Sbjct: 680 HQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 1001 GEMYVVMKNAGLS-GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
E+ + A ++ T LE E+ +L ++ + LQ + L+ +
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
Query: 1060 AKL---EGDKDVFANKYKALENE----NSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
KL E +K + ++ L E + L+N+ +T E++ + + L +L
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD 1172
+ +SD + +D + K++L ++ + K+ +
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAI-----LDLEKTCKELKHQLQVQMENTLKEQKE 914
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+++ +L++ ++++ + L L + +SE+ +
Sbjct: 915 LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL--KQSSEQKK 972
Query: 1233 LQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE-------DALRQ 1285
Q ++ E K L+ +L+ + ++T +AA+ I L+ + +Q
Sbjct: 973 KQIEALQGELKIAVLQKT--ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 1286 TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQL 1345
+D Y + E++ R Q++L + + ++ K A L
Sbjct: 1031 LQSDFYGRES---ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087
Query: 1346 KSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNK 1405
+ D AK E S K KEL + +S+ +++ ++ +K++
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSL---KEKELVNE-KSKLAEIEEIKCRQEKEITKL 1143
Query: 1406 DAELATLKGKLKILEQNSGAGAKRIT-ELKQEYEETVKKLEHSLALEKAEYEELTGKY-- 1462
+ EL + K + I E + AK++ + K E + L+ ++ EK + L +
Sbjct: 1144 NEELKSHKLE-SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
Query: 1463 --ELLEEEHVVTKARLTVE-KEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
E L++E + +A+L E KE+ G H + E + +I L E LGT W +
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM-QITALNENLGTVKKEWQSS- 1260
Query: 1520 TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
Q ++ L+++ E+ A L A + + E RA +R
Sbjct: 1261 ---QRRVSELEKQTDDLRGEI--AVLEATVQNNQDERRALLER 1298
Score = 57.6 bits (133), Expect = 4e-07
Identities = 187/1060 (17%), Positives = 402/1060 (37%), Gaps = 86/1060 (8%)
Query: 774 LAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ------KKPKTLIKSRS----- 822
L + V +L E+ +++ L E++ E L EL Q KP L+ S
Sbjct: 80 LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS 139
Query: 823 ----LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA--DNEKLQTENKKLQLLKNAKS 876
L+ + +N ++K+ + EQ+A+ L + +++ D E+ E + ++ + +
Sbjct: 140 LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEE 199
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIK-ELEMI--CQDEKSEKKVRFTEATKKETDTL 933
L + + + KT L+ E +A +K EL + D + ++ R +E K E+
Sbjct: 200 LNKEATV-IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDESKKF 258
Query: 934 KSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMV 993
+S Q + + + KS + +K LT L LKK
Sbjct: 259 ES-QYASSEATISQLRSELSKGPQEVRVYVQELQKLKSSVNELTQKNQTLTENL-LKKEQ 316
Query: 994 EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID--EIRSKLSKNDSEFTNEKNRLQTE 1051
+ + E E + +S K + A T +K++D +++S+LS +++ +R+ E
Sbjct: 317 DYTKLE--EKH---NEESVSKKNIQA-TLHQKDLDCQQLQSRLSASETSL----HRIHVE 366
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL--- 1108
+++ + KL+ + KY+ L+ E L Q + + +++IN+L + L
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 1109 -KNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKT 1167
+ + + +++ K + L+ DKT
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 1168 KKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELT 1227
K+ ++ + + + + +L + +S+ L
Sbjct: 487 KQ--QHQEQQALQQSTTAKLREAQNDLEQVLRQIGEKDQKIQNLEALLQKSKENISL-LE 543
Query: 1228 SEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QT 1286
E+++L A+ E + L ++++ ++++T L + + KQ ++ L Q
Sbjct: 544 KEREDLYAKIQAGEGETAVLN-QLQEKNHTLQDEVTQLTENVKNQSESHKQAQENLHDQV 602
Query: 1287 TNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE-KTEAESSAAKLEMAQL 1345
K + ++ + +++++ I+++ KTE SA + AQ
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ- 661
Query: 1346 KSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNK 1405
A L+N + + ++ LQ +++ ++ +H K+ K K
Sbjct: 662 ---RADLQNHLDTAQNALQDKHQELNKITTQLDQVTAKLQDKQEHCSQLE-SHLKEYKEK 717
Query: 1406 ----DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALE---KAEYEEL 1458
+ + L+G++K LE +S E+K E+ ++ L+ L + EL
Sbjct: 718 YLSLEQKTEELEGQIKKLEADS-------LEVKASKEQALQDLQQQRQLNTDLELRATEL 770
Query: 1459 TGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTE 1518
+ + E+ E+ +V+ RL ++K+ L ++++L+ E + L++ T S +
Sbjct: 771 SKQLEM--EKEIVSSTRLDLQKKSE--ALESIKQKLTKQEEEKQILKQDFETLSQETKIQ 826
Query: 1519 KTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXX 1578
E+ N I + L ++E+ L L + +L +D L++
Sbjct: 827 HEELNNRIQTTVTEL--QKVKMEKEALMTELSTVKDKLSKVSDS---LKNSKSEFEKENQ 881
Query: 1579 XXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAE-ITDTKTRYEGQM 1637
D E+ K + EQ E + E + + + ++
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTLK--------EQKELKKSLEKEKEASHQLKLEL 933
Query: 1638 NTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEY 1697
N+M+++L N + + +E + + ++S +E K A I+ + E
Sbjct: 934 NSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS-SEQKKKQIEALQGELKIAVLQKTEL 992
Query: 1698 RNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLS 1757
NK L+QQ+ EL + S L + + + ++ R +E R
Sbjct: 993 ENK---LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDL 1049
Query: 1758 SGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
LA ++ + Q +L+QE T L Q
Sbjct: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ 1089
>BC114545-1|AAI14546.1| 1939|Homo sapiens myosin, heavy chain 1,
skeletal muscle, adult protein.
Length = 1939
Score = 90.6 bits (215), Expect = 5e-17
Identities = 172/947 (18%), Positives = 376/947 (39%), Gaps = 80/947 (8%)
Query: 187 IEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTN----LKPPVRGGP 242
I+ E++ L S E EK R ER+ K + + + +++ + N L ++
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE 1088
Query: 243 XXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRL 302
+ +KE Q +IE L++E++ R + EK++SD L R L
Sbjct: 1089 FEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-LSREL 1147
Query: 303 ANIDTANKYTTGRSSEVLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTE 361
I + G +S +++ +K E DL E+ L + + S
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATLRKKHADSVA 1205
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSS 419
QI+ L+ E E+ E +D+ + + ++ R EDQ E +
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKT 1265
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKE 477
E ++ I + L+ + + + ++ + ++ E + + ++ G Q E ++
Sbjct: 1266 KEEEQQRLIND---LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQ 1322
Query: 478 LEQEVARSTEVALRLQRELAEAN---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
LE+E+ + +A LQ + + ++ + ++ + + S + R + D
Sbjct: 1323 LEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETD 1382
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEE--ETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
Q +L+++ ++ L ++L++AEE E N K + + + D+ +
Sbjct: 1383 AIQRTEELEEAKKK---LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERT 1439
Query: 593 ETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHM 645
++ K + + K+K + ++ + +E++ F Y + +
Sbjct: 1440 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQL 1499
Query: 646 AANNLRKTAARVEEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDE 704
L++ ++++ L Q+ + + +K+ K ++ A + E +
Sbjct: 1500 --ETLKRENKNLQQEISDLTEQIAEGGKRIHELKKIKKQVEQEKSELQAALEEAEASLEH 1557
Query: 705 ADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
+ +++ LELN+ ++ V RK+ E +++ + +K+ + + S S A
Sbjct: 1558 EEGKILRIQLELNQVKSEV-DRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI 1616
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
R K +E +++E+ +L R+ AE + + ++K L
Sbjct: 1617 R------------LKKKMEGDLNEMEIQL----NHANRMAAEALRNYRNTQAILKDTQLH 1660
Query: 825 ASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSL 877
D + DLK QL ++E+ A++L+A+ + L A E+ + E + L + + L
Sbjct: 1661 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1720
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ +NTKK +LE ++ + +++++ ++ + + K T+A + LK +Q
Sbjct: 1721 HTQNTSLINTKK--KLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMM-AEELKKEQ 1777
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE 997
Q L + A K K +I K L+ V +LE
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK----------LEARVRELE 1827
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
GE+ K + K + + KE+ + KN + ++LQ ++ K
Sbjct: 1828 ---GEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1884
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
+ E +V +K++ +++E + E E+Q+NKL
Sbjct: 1885 QAEEAEEQSNVNLSKFRRIQHE-------LEEAEERADIAESQVNKL 1924
Score = 85.0 bits (201), Expect = 2e-15
Identities = 170/917 (18%), Positives = 357/917 (38%), Gaps = 85/917 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
+ E +E AE+ E E + L++ +++LE ++K+ +K+ ++T+ A
Sbjct: 928 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 987
Query: 758 GSNTTARRSLTTNSNKLAEERVKVLED-EIDEVRKKLIEKERDCERLHAELSLAQKKPKT 816
G + T + LT L E + L+D + +E + + K A++ L Q+
Sbjct: 988 GLDETIAK-LTKEKKALQEAHQQTLDDLQAEEDKVNTLTK--------AKIKLEQQVDDL 1038
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA-- 874
SL+ + +DL+R + +E + + + T +E D ++L + KK + +
Sbjct: 1039 ---EGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQ 1095
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT-- 932
+ ++AL + QL+ ++KE A+I+ELE + E++ + +A K+ +D
Sbjct: 1096 SKIEDEQALGM------QLQKKIKELQARIEELEEEIEAERASR----AKAEKQRSDLSR 1145
Query: 933 -LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR------IPKKPTDLTT 985
L+ +A + ++ D +++ + KK D
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1205
Query: 986 KL-----QLKKMVEDLECEIGEMYVVMKNAGLSGKEMT-AKTKLEKEIDEIRSKLSKNDS 1039
+L L+++ + LE E EM + + + + + ++ AK LEK + +LS
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS---- 1261
Query: 1040 EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
E ++ Q I L A+L+ + ++ + + S LS + T++++ +
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKR 1321
Query: 1100 QINK-LSADLKNATSLQTTMSDC---MXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQ 1154
Q+ + + A A +LQ++ DC +V + TK +
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYET 1381
Query: 1155 DKNKLLKEVGDKTKKIG----DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXX 1210
D + +E+ + KK+ D C +EK ++ V
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNA 1441
Query: 1211 QAVVLANTHR---RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLES 1267
L R ++ E + +E A ++ + +L E+ +K YE + LE+
Sbjct: 1442 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLET 1501
Query: 1268 TIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMV-EMRXXXXXXXXXXXXXQDELNNAKI 1326
+K+ L+Q +D ++ + + E++ Q L A+
Sbjct: 1502 --------LKRENKNLQQEISDLTEQIAEGGKRIHELKKIKKQVEQEKSELQAALEEAEA 1553
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQS 1386
LE E + +LE+ Q+KS++ + E+ LD +++S
Sbjct: 1554 SLEHEEGKILRIQLELNQVKSEVDR--KIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRS 1611
Query: 1387 ERKKLDRMRIAHDKDVKNKDAEL--ATLKGKLKILEQNSGAGAKRITEL--------KQE 1436
R R++ + D+ + +L A + + + T+L +++
Sbjct: 1612 -RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQED 1670
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ------GELLHV 1490
+E + +E L +AE EEL E E + + L E+ Q L++
Sbjct: 1671 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1730
Query: 1491 QKELSTALGEIKTLQEKLGTESA-AWNTEKTEMQNSIASLQERLCGGGWEVERARLNARL 1549
+K+L T + +I+ E + E+ A K + ++ +E R+ L
Sbjct: 1731 KKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790
Query: 1550 DQRERELRAANDRRDVL 1566
+Q ++L+ D + L
Sbjct: 1791 EQTVKDLQHRLDEAEQL 1807
Score = 83.8 bits (198), Expect = 6e-15
Identities = 209/1129 (18%), Positives = 425/1129 (37%), Gaps = 81/1129 (7%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + E+ + +L E +EL ++ + +E DL
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV--- 895
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG 465
+ +AD + +Q IK L K+K+ +A+ E+ AE K ++
Sbjct: 896 -----QAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
Query: 466 PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETV--KVSR 523
++++ I +LE +A+ + + ++ + G + ++ K+ + + + +
Sbjct: 951 CSELKKD--IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
+L ++ED L + LE++ DL L ++ + ++ D ++ +
Sbjct: 1009 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1068
Query: 583 NIVTCDI-HESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSI 641
+ T DI ++ + + ++ K + S E + + + K +E Q + +
Sbjct: 1069 S--TMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIE----EL 1122
Query: 642 FNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKE 701
+ A R + A+ E+ L +L+++ S +L A IE N E E
Sbjct: 1123 EEEIEAE--RASRAKAEKQRSDLSRELEEI-----SERLEEAGGATSAQIE-MNKKREAE 1174
Query: 702 TDEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSKISSVTKTSA 757
+ + L+ +E A LR+K V EL + + L++ VK+ K S K
Sbjct: 1175 FQKMRRDLEEATLQ-HEATAATLRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEMKMEI 1232
Query: 758 GSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTL 817
+ +++ L E+ + LED++ E++ K E++R L A+ + Q +
Sbjct: 1233 DDLASNMETVSKAKGNL-EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEY 1291
Query: 818 IKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSL 877
SR LD D L R Q Q+ L+ + LE + + LQ ++ L
Sbjct: 1292 --SRQLDEKDTLVSQLSRGKQAFTQQIEELK---RQLEEEIKAKSALAHALQSSRHDCDL 1346
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
++ + K +L+ + +A +++ + + + ++ EA KK L+ +
Sbjct: 1347 LREQYEEEQEAK-AELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFK--PRIPKKPTDLTTKL-QLKKMVE 994
Q ++ L D +++ + KK + L + K+ E
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
+ E+ ++ LS + K E+ +D++ + E LQ EI+
Sbjct: 1466 ETHAELEASQ--KESRSLSTELFKIKNAYEESLDQLET--------LKRENKNLQQEISD 1515
Query: 1055 LKDVNAKLEGDKDVFANK--YKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
L + A EG K + K K +E E S L + +++ E +I ++ +L
Sbjct: 1516 LTEQIA--EGGKRIHELKKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVK 1573
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEV-GDKTKKIG 1171
S +D + D +L K++ GD +
Sbjct: 1574 S--EVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI 1631
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
+ + KD LA RR ++ L +E +
Sbjct: 1632 QLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANL-LQAEIE 1690
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYE---NKITSLESTIAAKDVHIKQ----LEDALR 1284
EL+A +TE E E+ D + + TSL +T + I Q +ED ++
Sbjct: 1691 ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQ 1750
Query: 1285 QTTN--DKYDEATSPVEMV--EMRXXXXXXXXXXXXXQDELNNAK-IKLEKTEAESSA-- 1337
+ N +K +A + M+ E++ ++ K ++ EAE A
Sbjct: 1751 EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1810
Query: 1338 -AKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
K ++ +L++ + +LE E K KEL + +RK + R++
Sbjct: 1811 GGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQD 1870
Query: 1397 AHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLE 1445
DK A++ + K + + E+ S + ++ E EE ++ +
Sbjct: 1871 LVDK----LQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERAD 1915
Score = 74.5 bits (175), Expect = 3e-12
Identities = 167/953 (17%), Positives = 360/953 (37%), Gaps = 60/953 (6%)
Query: 183 KEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGP 242
K EKE K E+ A+ + +R ++ + LMQ KN +L+ V+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKN-----DLQLQVQAEA 899
Query: 243 XXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRL 302
+++ +KE ++ E ++ L + ++E E S++
Sbjct: 900 DSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL----K 955
Query: 303 ANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREI-ESELETRPSTE 361
+ID E + KV LT L + LT++ + + E+ +T +
Sbjct: 956 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
A+ ++ L + E ++L E KK DL ++ + + Q + +
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQ-ESTMDIE 1074
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE 481
+ +Q + + F++ + K + + + +KK+ E+ + ++ E I+
Sbjct: 1075 NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE--IEAERAS 1132
Query: 482 VARSTEVALRLQRELAEANSKF------TGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP 535
A++ + L REL E + + T + + K + E K+ R E
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 536 AQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES--E 593
A LR + + A+L EQ+ N + ++ ++ + N+ T + E
Sbjct: 1193 AATLR--KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLE 1250
Query: 594 TVTNSIQNKMIHAASTPSSKEK--SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR 651
+ ++++++ + +++ +D TE ++ L + +
Sbjct: 1251 KMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQ 1310
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK-ETDEADPAEM 710
++EE L ++K + A + + S + L + + + K E A
Sbjct: 1311 AFTQQIEELKRQLEEEIKAKSALAHALQ-SSRHDCDLLREQYEEEQEAKAELQRAMSKAN 1369
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ + + T ++ EELE+ K+ L +++++ + +V A T +R
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 771 SNKLAE-ERVKVLEDEIDEVR----KKLIEKERDCERLHAELSLAQKKPKTL------IK 819
+ + + ER +D+ + K L E ++ CE HAEL +QK+ ++L IK
Sbjct: 1430 EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIK 1489
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEAS-----VLRAKTQSLEADNEKLQTENKKLQLLKNA 874
+ ++ DQ LKR+ + ++QE S + + E K Q E +K +L A
Sbjct: 1490 NAYEESLDQLET-LKRENKNLQQEISDLTEQIAEGGKRIHELKKIKKQVEQEKSEL--QA 1546
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK 934
++ +L+ K +++ EL + +++ +E + K + TL
Sbjct: 1547 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD 1606
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE 994
++ + L A ++ + + T+L L +
Sbjct: 1607 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALR 1666
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
E ++ +V + A L L+ EI+E+R+ L + + + + E+
Sbjct: 1667 SQEDLKEQLAMVERRANL----------LQAEIEELRATLEQTE----RSRKIAEQELLD 1712
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ L N K LE + S + + + + +E +N E + K D
Sbjct: 1713 ASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITD 1765
Score = 74.1 bits (174), Expect = 5e-12
Identities = 158/746 (21%), Positives = 283/746 (37%), Gaps = 76/746 (10%)
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K +LE +I E+ + ++++ E E L + KL+D ++L+ D D +E E
Sbjct: 916 KIQLEAKIKEVTER-AEDEEEINAE---LTAKKRKLEDECSELKKDIDDLELTLAKVEKE 971
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXX 1139
N+ K LTEEM + I KL+ + K +LQ +
Sbjct: 972 KHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDDLQAEEDKVNTLTKAK 1028
Query: 1140 XXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVT 1199
QVD+ + + K+ ++ +K+ + ++QL + +
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE 1088
Query: 1200 XXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYE 1259
L ++ EL + +EL+ + E + DL + E
Sbjct: 1089 FEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1148
Query: 1260 NKITSLESTIAAKDVHIK--QLEDALRQTTNDKYDEATSPVE--MVEMRXXXXXXXXXXX 1315
LE A I+ + +A Q +EAT E +R
Sbjct: 1149 EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELG 1208
Query: 1316 XXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
D L K KLEK ++E ++A ++K + E
Sbjct: 1209 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE 1268
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+ + L DL ++R +L + + + KD TL + L + A ++I ELK+
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKD----TLVSQ---LSRGKQAFTQQIEELKR 1321
Query: 1436 EYEETVK-KLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
+ EE +K K + AL+ + ++ +LL E++ E+++A+ EL Q+ +
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHD-----CDLLREQY--------EEEQEAKAEL---QRAM 1365
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
S A E+ + K T+ A TE E++ + L +RL VE +NA+ E+
Sbjct: 1366 SKANSEVAQWRTKYETD-AIQRTE--ELEEAKKKLAQRLQDAEEHVE--AVNAKCASLEK 1420
Query: 1555 -ELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXX 1613
+ R N+ D++ + K QR
Sbjct: 1421 TKQRLQNEVEDLM-----------IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1469
Query: 1614 XIEQSEKARKA---EITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
+E S+K ++ E+ K YE + D+L++L +RE N +Q + +
Sbjct: 1470 ELEASQKESRSLSTELFKIKNAYEESL----DQLETL-------KRENKNLQQEISDLTE 1518
Query: 1671 SMAEIKNGDKSARIHR-NSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
+AE G K RIH I E+E A LE+ A LE E E ++L ++ EL
Sbjct: 1519 QIAE---GGK--RIHELKKIKKQVEQEKSELQAALEEAEASLEHE--EGKIL--RIQLEL 1569
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERL 1755
KS + ++AE +++ + +
Sbjct: 1570 NQVKSEVDRKIAEKDEEIDQMKRNHI 1595
Score = 63.3 bits (147), Expect = 9e-09
Identities = 126/559 (22%), Positives = 218/559 (38%), Gaps = 42/559 (7%)
Query: 1225 ELTSEKDEL---QARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK---Q 1278
E K+EL +A+ + E K +TL E DL+ + + SL D IK Q
Sbjct: 859 EFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQ 918
Query: 1279 LEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQD--ELNNAKIKLEKTEAESS 1336
LE +++ T DE E+ + D EL AK++ EK E+
Sbjct: 919 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 978
Query: 1337 AAKL--EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM 1394
L EMA L +AKL E+K L +++D +
Sbjct: 979 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDL 1038
Query: 1395 RIAHDKDVK-NKDAELA--TLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLA-- 1449
+ +++ K D E A L+G LK+ ++++ I KQ+ +E +KK E ++
Sbjct: 1039 EGSLEQEKKIRMDLERAKRKLEGDLKLAQEST----MDIENDKQQLDEKLKKKEFEMSGL 1094
Query: 1450 LEKAEYEELTG---KYELLEEEHVVTKARLTVEKEQAQGELLHVQK-ELSTALGEI-KTL 1504
K E E+ G + ++ E + + + +E E+A Q+ +LS L EI + L
Sbjct: 1095 QSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 1505 QEKLGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAAND 1561
+E G SA K E Q L+E E A L + EL D
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATL--QHEATAATLRKKHADSVAELGEQID 1212
Query: 1562 R-RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEK 1620
+ V + + E VSK + E+ ++
Sbjct: 1213 NLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQR 1272
Query: 1621 ARKAEITDTKTRYE---GQMNTMRDELKSLHNQVSR----FRRERDNYKQMLEAAQKSMA 1673
++T + R + G+ + DE +L +Q+SR F ++ + K+ LE K+ +
Sbjct: 1273 LIN-DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKS 1331
Query: 1674 EIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEK 1733
+ + +S+R + + EEE K A L++ ++ E+ + R +K T+ +
Sbjct: 1332 ALAHALQSSRHDCDLLREQYEEEQEAK-AELQRAMSKANSEVAQWR---TKYETDAIQRT 1387
Query: 1734 SSAEVRLAEMQSRLNEYEE 1752
E ++ RL + EE
Sbjct: 1388 EELEEAKKKLAQRLQDAEE 1406
>AF111785-1|AAD29951.1| 1939|Homo sapiens myosin heavy chain IIx/d
protein.
Length = 1939
Score = 89.8 bits (213), Expect = 9e-17
Identities = 172/947 (18%), Positives = 375/947 (39%), Gaps = 80/947 (8%)
Query: 187 IEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTN----LKPPVRGGP 242
I+ E++ L S E EK R ER+ K + + + +++ + N L ++
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIENDKQQLDEKLKKKE 1088
Query: 243 XXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRL 302
+ +KE Q +IE L++E++ R + EK++SD L R L
Sbjct: 1089 FEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-LSREL 1147
Query: 303 ANIDTANKYTTGRSSEVLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTE 361
I + G +S +++ +K E DL E+ L + + S
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATLRKKHADSVA 1205
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSS 419
QI+ L+ E E+ E +D+ + + ++ R EDQ E +
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKT 1265
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKE 477
E ++ I + L+ + + + ++ + ++ E + + ++ G Q E ++
Sbjct: 1266 KEEEQQRLIND---LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQ 1322
Query: 478 LEQEVARSTEVALRLQRELAEAN---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
LE+E+ + +A LQ + + ++ + ++ + + S + R + D
Sbjct: 1323 LEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETD 1382
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEE--ETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
Q +L+++ ++ L ++L++AEE E N K + + + D+ +
Sbjct: 1383 AIQRTEELEEAKKK---LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERT 1439
Query: 593 ETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHM 645
++ K + + K+K + ++ + +E++ F Y + +
Sbjct: 1440 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQL 1499
Query: 646 AANNLRKTAARVEEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDE 704
L++ ++++ L Q+ + + K+ K ++ A + E +
Sbjct: 1500 --ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEH 1557
Query: 705 ADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
+ +++ LELN+ ++ V RK+ E +++ + +K+ + + S S A
Sbjct: 1558 EEGKILRIQLELNQVKSEV-DRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI 1616
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
R K +E +++E+ +L R+ AE + + ++K L
Sbjct: 1617 R------------LKKKMEGDLNEMEIQL----NHANRMAAEALRNYRNTQAILKDTQLH 1660
Query: 825 ASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSL 877
D + DLK QL ++E+ A++L+A+ + L A E+ + E + L + + L
Sbjct: 1661 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1720
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ +NTKK +LE ++ + +++++ ++ + + K T+A + LK +Q
Sbjct: 1721 HTQNTSLINTKK--KLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMM-AEELKKEQ 1777
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE 997
Q L + A K K +I K L+ V +LE
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK----------LEARVRELE 1827
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
GE+ K + K + + KE+ + KN + ++LQ ++ K
Sbjct: 1828 ---GEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1884
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
+ E +V +K++ +++E + E E+Q+NKL
Sbjct: 1885 QAEEAEEQSNVNLSKFRRIQHE-------LEEAEERADIAESQVNKL 1924
Score = 82.2 bits (194), Expect = 2e-14
Identities = 169/917 (18%), Positives = 355/917 (38%), Gaps = 85/917 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
+ E +E AE+ E E + L++ +++LE ++K+ +K+ ++T+ A
Sbjct: 928 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 987
Query: 758 GSNTTARRSLTTNSNKLAEERVKVLED-EIDEVRKKLIEKERDCERLHAELSLAQKKPKT 816
G + T + LT L E + L+D + +E + + K A++ L Q+
Sbjct: 988 GLDETIAK-LTKEKKALQEAHQQTLDDLQAEEDKVNTLTK--------AKIKLEQQVDDL 1038
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA-- 874
SL+ + +DL+R + +E + + + +E D ++L + KK + +
Sbjct: 1039 ---EGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIENDKQQLDEKLKKKEFEMSGLQ 1095
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT-- 932
+ ++AL + QL+ ++KE A+I+ELE + E++ + +A K+ +D
Sbjct: 1096 SKIEDEQALGM------QLQKKIKELQARIEELEEEIEAERASR----AKAEKQRSDLSR 1145
Query: 933 -LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR------IPKKPTDLTT 985
L+ +A + ++ D +++ + KK D
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1205
Query: 986 KL-----QLKKMVEDLECEIGEMYVVMKNAGLSGKEMT-AKTKLEKEIDEIRSKLSKNDS 1039
+L L+++ + LE E EM + + + + + ++ AK LEK + +LS
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS---- 1261
Query: 1040 EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
E ++ Q I L A+L+ + ++ + + S LS + T++++ +
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKR 1321
Query: 1100 QINK-LSADLKNATSLQTTMSDC---MXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQ 1154
Q+ + + A A +LQ++ DC +V + TK +
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYET 1381
Query: 1155 DKNKLLKEVGDKTKKIG----DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXX 1210
D + +E+ + KK+ D C +EK ++ V
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNA 1441
Query: 1211 QAVVLANTHR---RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLES 1267
L R ++ E + +E A ++ + +L E+ +K YE + LE+
Sbjct: 1442 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLET 1501
Query: 1268 TIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMV-EMRXXXXXXXXXXXXXQDELNNAKI 1326
+K+ L+Q +D ++ + + E+ Q L A+
Sbjct: 1502 --------LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEA 1553
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQS 1386
LE E + +LE+ Q+KS++ + E+ LD +++S
Sbjct: 1554 SLEHEEGKILRIQLELNQVKSEVDR--KIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRS 1611
Query: 1387 ERKKLDRMRIAHDKDVKNKDAEL--ATLKGKLKILEQNSGAGAKRITEL--------KQE 1436
R R++ + D+ + +L A + + + T+L +++
Sbjct: 1612 -RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQED 1670
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ------GELLHV 1490
+E + +E L +AE EEL E E + + L E+ Q L++
Sbjct: 1671 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1730
Query: 1491 QKELSTALGEIKTLQEKLGTESA-AWNTEKTEMQNSIASLQERLCGGGWEVERARLNARL 1549
+K+L T + +I+ E + E+ A K + ++ +E R+ L
Sbjct: 1731 KKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790
Query: 1550 DQRERELRAANDRRDVL 1566
+Q ++L+ D + L
Sbjct: 1791 EQTVKDLQHRLDEAEQL 1807
Score = 79.0 bits (186), Expect = 2e-13
Identities = 235/1187 (19%), Positives = 451/1187 (37%), Gaps = 142/1187 (11%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
KI+ + ET + E+ + +L E +EL ++ + +E DL
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898
Query: 406 QDNFR--EDQADEYSSLRRELEQTIKNCRV-----------LSFKLKKTERKADQLEQEK 452
D+ E++ D+ + +LE IK L+ K +K E + +L+++
Sbjct: 899 ADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
+ E L ++ + EN++K L +E+A E +L +E + L
Sbjct: 959 DDLELTLAKVE--KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL-- 1014
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q E KV+ +LT+ + + Q + DL+ SLE+E +R L A+ + ++
Sbjct: 1015 --QAEEDKVN--TLTKAKIKLE--QQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1068
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ +D + ++ + + ++ K + S E + + + K +E Q
Sbjct: 1069 SAMDIE-----------NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQA 1117
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
+ + + A R + A+ E+ L +L+++ S +L A IE
Sbjct: 1118 RIE----ELEEEIEAE--RASRAKAEKQRSDLSRELEEI-----SERLEEAGGATSAQIE 1166
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRK----VEELEQDKEALKKQVKELTSK 748
N E E + + L+ +E A LR+K V EL + + L++ VK+ K
Sbjct: 1167 M-NKKREAEFQKMRRDLEEATLQ-HEATAATLRKKHADSVAELGEQIDNLQR-VKQKLEK 1223
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS 808
S K + +++ L E+ + LED++ E++ K E++R L A+ +
Sbjct: 1224 EKSEMKMEIDDLASNMETVSKAKGNL-EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRA 1282
Query: 809 LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL 868
Q + SR LD D L R Q A TQ +E +L+ E K
Sbjct: 1283 RLQTESGEY--SRQLDEKDTLVSQLSRGKQ----------AFTQQIEELKRQLEEEIKAK 1330
Query: 869 QLLKNA-KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
L +A +S R D DL + Q E E +EA A+++ E ++ + TK
Sbjct: 1331 SALAHALQSSRHD--CDLLRE---QYEEE-QEAKAELQRAMSKANSEVAQWR------TK 1378
Query: 928 KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL 987
ETD ++ + + L DA++ + K + TK
Sbjct: 1379 YETDAIQRTEELEEA---------------KKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 988 QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+L+ VEDL ++ NA + A K ++ D+I ++ + E E
Sbjct: 1424 RLQNEVEDLMIDVERT-----NAACA-----ALDKKQRNFDKILAEWKQKCEETHAELEA 1473
Query: 1048 LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
Q E L K++ + ++ + L+ EN NL + LTE++ +I++L
Sbjct: 1474 SQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI 1533
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKT 1167
K ++ + + QV K+++ +++ +K
Sbjct: 1534 KKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQV---------KSEVDRKIAEKD 1584
Query: 1168 KKIGDXXXXXXXXXXXCKR-IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIEL 1226
++I + ++ ++ +R D + + L N R++ E
Sbjct: 1585 EEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQL-NHANRMAAEA 1643
Query: 1227 TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQT 1286
QA T+ + L+ +R + D + ++ +E I++L L QT
Sbjct: 1644 LRNYRNTQAILKDTQ---LHLDDALRS-QEDLKEQLAMVERRANLLQAEIEELRATLEQT 1699
Query: 1287 TNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQD-ELNNAKIKLEKTEAESSAAKLEMAQL 1345
+ ++ E Q+ L N K KLE + S + EM +
Sbjct: 1700 ERSR--------KIAEQELLDASERVQLLHTQNTSLINTKKKLE---TDISQIQGEMEDI 1748
Query: 1346 KSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNK 1405
+ E E KE DT ER K + + D +
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMA------EELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1802
Query: 1406 DAELATLKGKLKILEQNSGAGAKRITELKQEYE---ETVKKL-EHSLALEKAEYEELTGK 1461
+AE LKG K +++ + E++ E + E VK L +H +++ Y+ +
Sbjct: 1803 EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDR 1862
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+L + +V K + V+ + Q E +++ + L + + +Q +L
Sbjct: 1863 KNILRLQDLVDKLQAKVKSYKRQAE--EAEEQSNVNLSKFRRIQHEL 1907
Score = 76.6 bits (180), Expect = 9e-13
Identities = 170/953 (17%), Positives = 366/953 (38%), Gaps = 60/953 (6%)
Query: 183 KEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGP 242
K EKE K E+ A+ + +R ++ + LMQ KN +L+ V+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKN-----DLQLQVQAEA 899
Query: 243 XXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRL 302
+++ +KE ++ E ++ L + ++E E S++
Sbjct: 900 DSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL----K 955
Query: 303 ANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREI-ESELETRPSTE 361
+ID E + KV LT L + LT++ + + E+ +T +
Sbjct: 956 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1015
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSS 419
A+ ++ L + E ++L E KK DL ++ + + ++ A + +
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIEN 1075
Query: 420 LRRELEQTIKNCRV----LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
+++L++ +K L K++ + QL+++ E + ++ E+ + +R +R
Sbjct: 1076 DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA-ERASRA 1134
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP 535
K +Q S E+ + L EA T + + K + E K+ R E
Sbjct: 1135 KAEKQRSDLSRELE-EISERLEEAGGA-TSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 536 AQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES--E 593
A LR + + A+L EQ+ N + ++ ++ + N+ T + E
Sbjct: 1193 AATLR--KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLE 1250
Query: 594 TVTNSIQNKMIHAASTPSSKEK--SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR 651
+ ++++++ + +++ +D TE ++ L + +
Sbjct: 1251 KMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQ 1310
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK-ETDEADPAEM 710
++EE L ++K + A + + S + L + + + K E A
Sbjct: 1311 AFTQQIEELKRQLEEEIKAKSALAHALQ-SSRHDCDLLREQYEEEQEAKAELQRAMSKAN 1369
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ + + T ++ EELE+ K+ L +++++ + +V A T +R
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 771 SNKLAE-ERVKVLEDEIDEVR----KKLIEKERDCERLHAELSLAQKKPKTL------IK 819
+ + + ER +D+ + K L E ++ CE HAEL +QK+ ++L IK
Sbjct: 1430 EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIK 1489
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEAS-----VLRAKTQSLEADNEKLQTENKKLQLLKNA 874
+ ++ DQ LKR+ + ++QE S + + E + K Q E +K +L A
Sbjct: 1490 NAYEESLDQLET-LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSEL--QA 1546
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK 934
++ +L+ K +++ EL + +++ +E + K + TL
Sbjct: 1547 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD 1606
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE 994
++ + L A ++ + + T+L L +
Sbjct: 1607 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALR 1666
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
E ++ +V + A L L+ EI+E+R+ L + + + + E+
Sbjct: 1667 SQEDLKEQLAMVERRANL----------LQAEIEELRATLEQTE----RSRKIAEQELLD 1712
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ L N K LE + S + + + + +E +N E + K D
Sbjct: 1713 ASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITD 1765
Score = 74.1 bits (174), Expect = 5e-12
Identities = 158/746 (21%), Positives = 283/746 (37%), Gaps = 76/746 (10%)
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
K +LE +I E+ + ++++ E E L + KL+D ++L+ D D +E E
Sbjct: 916 KIQLEAKIKEVTER-AEDEEEINAE---LTAKKRKLEDECSELKKDIDDLELTLAKVEKE 971
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXX 1139
N+ K LTEEM + I KL+ + K +LQ +
Sbjct: 972 KHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDDLQAEEDKVNTLTKAK 1028
Query: 1140 XXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVT 1199
QVD+ + + K+ ++ +K+ + ++QL + +
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIENDKQQLDEKLKKKE 1088
Query: 1200 XXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYE 1259
L ++ EL + +EL+ + E + DL + E
Sbjct: 1089 FEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1148
Query: 1260 NKITSLESTIAAKDVHIK--QLEDALRQTTNDKYDEATSPVE--MVEMRXXXXXXXXXXX 1315
LE A I+ + +A Q +EAT E +R
Sbjct: 1149 EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELG 1208
Query: 1316 XXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
D L K KLEK ++E ++A ++K + E
Sbjct: 1209 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE 1268
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+ + L DL ++R +L + + + KD TL + L + A ++I ELK+
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKD----TLVSQ---LSRGKQAFTQQIEELKR 1321
Query: 1436 EYEETVK-KLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
+ EE +K K + AL+ + ++ +LL E++ E+++A+ EL Q+ +
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHD-----CDLLREQY--------EEEQEAKAEL---QRAM 1365
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
S A E+ + K T+ A TE E++ + L +RL VE +NA+ E+
Sbjct: 1366 SKANSEVAQWRTKYETD-AIQRTE--ELEEAKKKLAQRLQDAEEHVE--AVNAKCASLEK 1420
Query: 1555 -ELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXX 1613
+ R N+ D++ + K QR
Sbjct: 1421 TKQRLQNEVEDLM-----------IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1469
Query: 1614 XIEQSEKARKA---EITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
+E S+K ++ E+ K YE + D+L++L +RE N +Q + +
Sbjct: 1470 ELEASQKESRSLSTELFKIKNAYEESL----DQLETL-------KRENKNLQQEISDLTE 1518
Query: 1671 SMAEIKNGDKSARIHR-NSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
+AE G K RIH I E+E A LE+ A LE E E ++L ++ EL
Sbjct: 1519 QIAE---GGK--RIHELEKIKKQVEQEKSELQAALEEAEASLEHE--EGKIL--RIQLEL 1569
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERL 1755
KS + ++AE +++ + +
Sbjct: 1570 NQVKSEVDRKIAEKDEEIDQMKRNHI 1595
Score = 64.5 bits (150), Expect = 4e-09
Identities = 127/559 (22%), Positives = 218/559 (38%), Gaps = 42/559 (7%)
Query: 1225 ELTSEKDEL---QARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK---Q 1278
E K+EL +A+ + E K +TL E DL+ + + SL D IK Q
Sbjct: 859 EFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQ 918
Query: 1279 LEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQD--ELNNAKIKLEKTEAESS 1336
LE +++ T DE E+ + D EL AK++ EK E+
Sbjct: 919 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 978
Query: 1337 AAKL--EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM 1394
L EMA L +AKL E+K L +++D +
Sbjct: 979 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDL 1038
Query: 1395 RIAHDKDVK-NKDAELA--TLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLA-- 1449
+ +++ K D E A L+G LK+ +++ A I KQ+ +E +KK E ++
Sbjct: 1039 EGSLEQEKKIRMDLERAKRKLEGDLKLAQES----AMDIENDKQQLDEKLKKKEFEMSGL 1094
Query: 1450 LEKAEYEELTG---KYELLEEEHVVTKARLTVEKEQAQGELLHVQK-ELSTALGEI-KTL 1504
K E E+ G + ++ E + + + +E E+A Q+ +LS L EI + L
Sbjct: 1095 QSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 1505 QEKLGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAAND 1561
+E G SA K E Q L+E E A L + EL D
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATL--QHEATAATLRKKHADSVAELGEQID 1212
Query: 1562 R-RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEK 1620
+ V + + E VSK + E+ ++
Sbjct: 1213 NLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQR 1272
Query: 1621 ARKAEITDTKTRYE---GQMNTMRDELKSLHNQVSR----FRRERDNYKQMLEAAQKSMA 1673
++T + R + G+ + DE +L +Q+SR F ++ + K+ LE K+ +
Sbjct: 1273 LIN-DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKS 1331
Query: 1674 EIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEK 1733
+ + +S+R + + EEE K A L++ ++ E+ + R +K T+ +
Sbjct: 1332 ALAHALQSSRHDCDLLREQYEEEQEAK-AELQRAMSKANSEVAQWR---TKYETDAIQRT 1387
Query: 1734 SSAEVRLAEMQSRLNEYEE 1752
E ++ RL + EE
Sbjct: 1388 EELEEAKKKLAQRLQDAEE 1406
>X03740-1|CAA27380.1| 876|Homo sapiens protein ( Human skeletal mRNA
for myosin heavy chain light meromyosin region. ).
Length = 876
Score = 85.4 bits (202), Expect = 2e-15
Identities = 161/865 (18%), Positives = 343/865 (39%), Gaps = 70/865 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE Q +IE L++E++ R + EK +SD L R L I + G +S ++
Sbjct: 45 LQKKIKELQARIEELEEEIEAERTSRAKAEKLRSD-LSRELEEISERLEEAVGATSTQIE 103
Query: 322 LQQKVN-ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+ +K E DL E+ L + + S QI+ L+ E
Sbjct: 104 MNKKREAEFQKMRRDL--EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE 161
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKL 438
E+ E +D+ + + ++ R EDQ E + E ++ I + +L
Sbjct: 162 KSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARL 221
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK-ELEQEVARSTEVALRLQRELA 497
++ + + + EK E +L G Q+ +K +LE+E+ + +A LQ
Sbjct: 222 QQNQVEYSRQLDEKDTLETQLSR--GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRH 279
Query: 498 EAN---SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+ + ++ + ++ + + S + R + D Q +L+++ ++ L +
Sbjct: 280 DCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKK---LAQ 336
Query: 555 QLRNAEE--ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
+L++AEE E N K + + + D+ + ++ K + +
Sbjct: 337 RLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQTNFDKILAE 396
Query: 613 -KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
K+K + ++ +E++ F Y + + L++ ++++ L
Sbjct: 397 WKQKCEETHAVLESFQKESRSLSTELFKIKNAYEESLDQL--ETLKRENKNLQQEISDLT 454
Query: 666 LQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVL 724
Q+ + + K+ K ++ A + E + + +++ LE+N+ ++ V
Sbjct: 455 EQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLEVNQVKSEV- 513
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLED 784
RK+ E +++ + +K+ + + S S A R K E + +E
Sbjct: 514 DRKIAEKDEEIDQMKRNHIRIEESMQSTLNAEIRSRNDAIRL-----KKKMEGDLNEMEI 568
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
+++ + E R+ + A L Q LD + + DLK QL ++E+ A
Sbjct: 569 QLNHANRMAAEDLRNYQNTQAILKDTQLH---------LDDALRSQEDLKEQLAMVERRA 619
Query: 845 SVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
++L+A+ + L A E+ + E + L + + L + +NTKK +LE ++ +
Sbjct: 620 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK--KLETDISQ 677
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+++++ ++ + + K T+A + LK +Q Q
Sbjct: 678 IQGEMEDIIKEARNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNLEQTVKDLQH 736
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTA 1019
L + A K K +I K L+ V +LE GE+ K + K +
Sbjct: 737 RLDEAEQLALKGGKKQIQK----------LEAKVRELE---GEVESEQKRNVEAVKGLHK 783
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
+ KE+ + KN + ++LQ ++ K + E +V +K++ +++E
Sbjct: 784 HERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHE 843
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKL 1104
+ E E+Q+NKL
Sbjct: 844 -------LEEAEERADIAESQVNKL 861
Score = 73.3 bits (172), Expect = 8e-12
Identities = 190/918 (20%), Positives = 366/918 (39%), Gaps = 101/918 (11%)
Query: 688 KLSIETAND--NDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKEL 745
KL+ E+A D ND+++ DE L+ E E + L+ K+E+ + L+K++KEL
Sbjct: 1 KLAQESAMDIENDKQQLDEK--------LKKKEFEMSGLQSKIEDEQALGMQLQKKIKEL 52
Query: 746 TSKISSVTKTSAGSNTTARRS--LTTNSNKLAEERVKVLEDEIDEVRKKL-IEKERDCE- 801
++I + + T+ ++ L ++ ++ EE + LE+ + ++ + K+R+ E
Sbjct: 53 QARIEELEEEIEAERTSRAKAEKLRSDLSRELEEISERLEEAVGATSTQIEMNKKREAEF 112
Query: 802 ----RLHAELSLAQKKPKTLIKSRSLDASDQ--QNVD-LKRQLQVIEQEASVLRAKTQSL 854
R E +L + ++ + D+ + + +D L+R Q +E+E S ++ + L
Sbjct: 113 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 172
Query: 855 EADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ--LENELKEALAKIKELEMICQ 912
++ E + L+ K ++L D+ ++ TK+ Q L N+L A++ Q
Sbjct: 173 ASNMETVSKAKGNLE--KMCRAL-EDQLSEIKTKEEEQQRLINDLTAQRARL-------Q 222
Query: 913 DEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSF 972
+ E + E ET + KQ A +L+
Sbjct: 223 QNQVEYSRQLDEKDTLETQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCD 282
Query: 973 KPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRS 1032
R + + K +L++ + E+ + K T + +E++E +
Sbjct: 283 LLR-EQYEEEQEAKAELQRAMSKANSEVAQWRT---------KYETDAIQRTEELEEAKK 332
Query: 1033 KLSKNDSEFTNEKNRLQTEIAKLKDVNAK---LEGDKDVFANKYKALENENSNLSNQCKT 1089
KL++ RLQ ++ VNAK LE K N+ + L + + C
Sbjct: 333 KLAQ----------RLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAA 382
Query: 1090 LTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY 1149
L ++ N +K+ A+ K + T + +D
Sbjct: 383 LDKKQTN----FDKILAEWKQ--KCEETHAVLESFQKESRSLSTELFKIKNAYEESLDQL 436
Query: 1150 TKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXX 1209
+ ++ L +E+ D T++I + K++E++ S + +
Sbjct: 437 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEE 496
Query: 1210 XQAV--------VLANTHRRLSIELTSEKDELQARFIK-TESKFITLEAEMRDLKADYEN 1260
+ + V + R+++ E E D+++ I+ ES TL AE+R + D
Sbjct: 497 GKILRIQLEVNQVKSEVDRKIA-EKDEEIDQMKRNHIRIEESMQSTLNAEIRS-RNDAIR 554
Query: 1261 KITSLESTIAAKDVHIKQLEDALRQTTND--KYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
+E + ++ QL A R D Y + ++ ++ Q
Sbjct: 555 LKKKMEGDLNEMEI---QLNHANRMAAEDLRNYQNTQAILKDTQLHLDDALRSQEDLKEQ 611
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
+ + L + E E A LE + +A+ E S N K
Sbjct: 612 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI--NTKK 669
Query: 1379 ELDTDL-QSERKKLDRMRIAHDKDVKNKDA--ELATLKGKLKILEQNSGAGAKRITELKQ 1435
+L+TD+ Q + + D ++ A + + K K A + A + +LK EQ++ A +R +K+
Sbjct: 670 KLETDISQIQGEMEDIIKEARNAEEKAKKAITDAAMMAEELK-KEQDTSAHLER---MKK 725
Query: 1436 EYEETVKKLEHSLALEKAEYEELT-GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
E+TVK L+H L++AE L GK ++ + E V + VE EQ + + K L
Sbjct: 726 NLEQTVKDLQH--RLDEAEQLALKGGKKQIQKLEAKVRELEGEVESEQKRN--VEAVKGL 781
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA--RLNARLDQR 1552
++K L + TE N +Q+ + LQ ++ + E A + N L +
Sbjct: 782 HKHERKVKELTYQ--TEEDRKNI--LRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKF 837
Query: 1553 ER---ELRAANDRRDVLE 1567
R EL A +R D+ E
Sbjct: 838 RRIQHELEEAEERADIAE 855
Score = 71.3 bits (167), Expect = 3e-11
Identities = 129/629 (20%), Positives = 278/629 (44%), Gaps = 68/629 (10%)
Query: 273 IEGLKQEVDILRKRCERVEKEKSDIL-LRRLANIDTAN---KYTTG---RSSEV----LK 321
++ + + D+LR++ E ++ K+++ AN + A KY T R+ E+ K
Sbjct: 274 LQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKK 333
Query: 322 LQQKVNELTTHNE-------DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL 374
L Q++ + H E L K+ L ++ ++ ++E + A + + K+
Sbjct: 334 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQTNFDKI 393
Query: 375 LAA-ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE---LEQTIKN 430
LA + CEE E +KE R L +++ + E+ D+ +L+RE L+Q I +
Sbjct: 394 LAEWKQKCEETHAVLESFQKESRSLSTELFKIKNAY-EESLDQLETLKRENKNLQQEISD 452
Query: 431 CRVL----SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST 486
++ + E+ Q+EQEK+E + L E + E +I ++ EV
Sbjct: 453 LTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE--HEEGKILRIQLEV---N 507
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL 546
+V + R++AE + + + +++ E+++ + ++ R S+ D +L + ++ L
Sbjct: 508 QVKSEVDRKIAEKDEEIDQMKRNHIRI--EESMQSTLNAEIR--SRNDAIRLKKKMEGDL 563
Query: 547 -EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTC--DIHES----ETVTNSI 599
E E L R A E+ N Q D Q+ D+ + D+ E E N +
Sbjct: 564 NEMEIQLNHANRMAAEDLRN-YQNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLL 622
Query: 600 QNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE 659
Q ++ +T E+S K E Q D H +L T ++E
Sbjct: 623 QAEIEELRATLEQTERS-------RKIAE--QELLDASERVQLLHTQNTSLINTKKKLET 673
Query: 660 DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQ 719
D + +++ + +AR+ + A K + A +E + ++ A ++ + + EQ
Sbjct: 674 DISQIQGEMEDIIKEARNAE----EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 729
Query: 720 EATVLRRKVEELEQ-DKEALKKQVKELTSKISSV---TKTSAGSNTTARRSLTTNSNKLA 775
L+ +++E EQ + KKQ+++L +K+ + ++ N A + L +
Sbjct: 730 TVKDLQHRLDEAEQLALKGGKKQIQKLEAKVRELEGEVESEQKRNVEAVKGLHKH----- 784
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E +VK L + +E RK ++ + ++L A++ +++ + + +++ S + + +
Sbjct: 785 ERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRI--QH 842
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTE 864
+L+ E+ A + ++ L + ++ T+
Sbjct: 843 ELEEAEERADIAESQVNKLRVKSREVHTK 871
Score = 62.5 bits (145), Expect = 1e-08
Identities = 166/804 (20%), Positives = 312/804 (38%), Gaps = 102/804 (12%)
Query: 715 ELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
EL EQ + R K ++LE++K +K ++ +L S + +V+K A+ +L
Sbjct: 143 ELGEQIDNLQRVK-QKLEKEKSEMKMEIDDLASNMETVSK--------AKGNL------- 186
Query: 775 AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLK 834
E+ + LED++ E++ K E++R L A+ + Q+ SR LD D L
Sbjct: 187 -EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQQNQVEY--SRQLDEKDTLETQLS 243
Query: 835 RQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA-KSLRSDKALDLNTKKTTQL 893
R Q A TQ +E +L+ E K L +A +S R D DL + Q
Sbjct: 244 RGKQ----------AFTQQIEELKRQLEEEIKAKSALAHALQSSRHD--CDLLRE---QY 288
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
E E +EA A+++ E ++ + TK ETD ++ +
Sbjct: 289 EEE-QEAKAELQRAMSKANSEVAQWR------TKYETDAIQRTEELEEA----------- 330
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ L DA++ + K + TK +L+ VEDL ++ A L
Sbjct: 331 ----KKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAAC--AALD 384
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDS---EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA 1070
K+ T +K + E + K + + F E L TE+ K+K NA E
Sbjct: 385 KKQ----TNFDKILAEWKQKCEETHAVLESFQKESRSLSTELFKIK--NAYEES-----L 433
Query: 1071 NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA----TSLQTTMSDCMXXXX 1126
++ + L+ EN NL + LTE++ +I++L K + LQ + +
Sbjct: 434 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE 493
Query: 1127 XXXXXXXXXXXXXXXXXXQVDNY-----TKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+VD +IDQ K ++ +
Sbjct: 494 HEEGKILRIQLEVNQVKSEVDRKIAEKDEEIDQMKRNHIRIEESMQSTLNAEIRSRNDAI 553
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQ----AVVLANTHRRLSIELTSEKDELQARF 1237
K++E L+ + ++ +L +T L L S++D L+ +
Sbjct: 554 RLKKKMEGDLNEMEIQLNHANRMAAEDLRNYQNTQAILKDTQLHLDDALRSQED-LKEQL 612
Query: 1238 IKTESKFITLEAEMRDLKADYE-----NKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
E + L+AE+ +L+A E KI E A++ V + ++ T K +
Sbjct: 613 AMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 672
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAE-SSAAKLEMAQ--LKSDL 1349
S ++ EM + + +A + E+ + E ++A LE + L+ +
Sbjct: 673 TDISQIQ-GEMEDIIKEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 731
Query: 1350 AKLENXXXXXXXXXXXXXXXS-SYWENKAKELDTDLQSERKK-LDRMRIAHDKDVKNKDA 1407
L++ E K +EL+ +++SE+K+ ++ ++ H + K K+
Sbjct: 732 KDLQHRLDEAEQLALKGGKKQIQKLEAKVRELEGEVESEQKRNVEAVKGLHKHERKVKEL 791
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE 1467
T + + IL ++ + Y+ ++ E + +++ + ++EL E
Sbjct: 792 TYQTEEDRKNILRLQD--LVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRI--QHELEEA 847
Query: 1468 EHVVTKARLTVEKEQAQGELLHVQ 1491
E A V K + + +H +
Sbjct: 848 EERADIAESQVNKLRVKSREVHTK 871
>M97501-1|AAA35693.1| 1392|Homo sapiens cytoplasmic linker protein-170
alpha-2 protein.
Length = 1392
Score = 85.4 bits (202), Expect = 2e-15
Identities = 168/871 (19%), Positives = 356/871 (40%), Gaps = 80/871 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+K E L +E + L+ + E KE SD++ + ++TA + ++ E LK+
Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA-SHQQAMEELKVSFS 600
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
L T + + K + + + + E+E Q +Q + A E L +LM
Sbjct: 601 -KGLGTETAEFAELKTQIEKMRLDYQHEIE-----NLQNQQDSERAAHAKEMEALRAKLM 654
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
++ + L + +D + D + L +E E +K VL K + +
Sbjct: 655 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIKVKELEVLQAKCNEQTKVI 713
Query: 446 DQLEQEKAEHEKKLLEIVG-GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
D + E+KLL++ + ++ +K+L Q++ + + L+ E +SK +
Sbjct: 714 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 773
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD-LREQLRNAEEET 563
S+ + Q +K++ QE+ ++ + ++++LE+E L+E+ A EE
Sbjct: 774 ----SITRELQGRELKLT-------NLQENLSE-VSQVKETLEKELQILKEKFAEASEEA 821
Query: 564 ANCKQVNPPTF--LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
+ ++ T L ++ N+++ D+ + ++ K +EK +
Sbjct: 822 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF---------REKDEREEQ 872
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
I + ++ +S N + E D E L L+L K A
Sbjct: 873 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL--- 929
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
+ SIE E+ EA + +E+E L RK+ +LE+ E Q
Sbjct: 930 ------QKSIEDMTVKAEQSQQEA--------AKKHEEEKKELERKLSDLEKKMETSHNQ 975
Query: 742 VKELTS---KISSVTKTSAGS-NTTARRSLTTNSNKL--AEERVKVLEDEIDEVRKKLIE 795
+EL + + +S TKT +++L +KL A E L E++E+RK+ E
Sbjct: 976 CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ-AE 1034
Query: 796 KERDCERLHAELSLAQKKPKTLIKS-RSLDASDQQNVDLKRQLQVIEQ----EASVLRAK 850
K + + + + ++ K ++ SL+ + Q N L+ +L +++ L
Sbjct: 1035 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1094
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
+ L +N+K++ K+++ LK A + +S + L ++ +L EL + ++ + +
Sbjct: 1095 KELLTVENQKMEEFRKEIETLKQAAAQKSQQ-LSALQEENVKLAEELGRSRDEVTSHQKL 1153
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
++E+S + E K+E+ +K A L+ L+++
Sbjct: 1154 -EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNE--- 1209
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEI 1030
+ + + L +V+ LE + ++ + +KN L KE K +L
Sbjct: 1210 -----VTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKE--NKRQLSSSSGNT 1262
Query: 1031 RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTL 1090
++ +++ ++ + L + I L+ N L+ ++ + AL +L+N
Sbjct: 1263 DTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE--AALNGNGDDLNNYD--- 1317
Query: 1091 TEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
+++ + + + +L D+ + L T DC
Sbjct: 1318 SDDQEKQSKKKPRLFCDICDCFDLHDT-EDC 1347
Score = 84.2 bits (199), Expect = 4e-15
Identities = 159/696 (22%), Positives = 307/696 (44%), Gaps = 79/696 (11%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D ++ E +D + L QE +I K E V + K + + + N + K T + ++ L
Sbjct: 676 DQHLVEMEDTLNKL-QEAEIKVKELE-VLQAKCNEQTKVIDNFTSQLKATEEKLLDLDAL 733
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAETLC 381
++ +E + + LR + + ++I+ +E E S + TR+++ KL +
Sbjct: 734 RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 793
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+ E ++KEL+ L ++ F E ++E S++R +++T+ K
Sbjct: 794 SEVSQVKETLEKELQIL-------KEKFAE-ASEEAVSVQRSMQETVN----------KL 835
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+K +Q ++ EK L E + + RE E E+++ ++ E +L+ ++AE
Sbjct: 836 HQKEEQFNMLSSDLEK-LRENLADMEAKFREK--DEREEQLIKAKE---KLENDIAEI-M 888
Query: 502 KFTGSNPS-LMKVPQPETVK---VSRSSLTRGGSQEDPAQLLRDLQD-SLEREADLREQL 556
K +G N S L K+ +K V L + E+ + L + ++D +++ E +E
Sbjct: 889 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 948
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN-KMIHAASTPSSKEK 615
+ EEE ++ + L+K++ ET N Q K + +T +K K
Sbjct: 949 KKHEEEKKELER--KLSDLEKKM-------------ETSHNQCQELKARYERATSETKTK 993
Query: 616 SDSPPLSIDKTTEETQFHF------DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
+ ++ KT +T+ + L + + AA+ ED ++ Q+
Sbjct: 994 HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMT 1053
Query: 670 KMATKARSRKLSPTPPAN-KLS--IETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
K T+ + L T N KL ++T +N+ K +E + + K LL + Q+ R+
Sbjct: 1054 KEKTETLA-SLEDTKQTNAKLQNELDTLKENNLKNVEELNKS--KELLTVENQKMEEFRK 1110
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
++E L+Q +Q+ L + + + S R T+ KL EER VL +++
Sbjct: 1111 EIETLKQAAAQKSQQLSALQEENVKLAEELGRS-----RDEVTSHQKLEEER-SVLNNQL 1164
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE--- 843
E++K+ + +D + A L QK I S L D + L+ ++ V+ E
Sbjct: 1165 LEMKKRESKFIKDADEEKASL---QKSIS--ITSALLTEKDAELEKLRNEVTVLRGENAS 1219
Query: 844 ASVLRAKTQSLEADNEKLQ--TENKKLQLLKNAKSLRSDKA-LDLNTKKTTQL-ENELKE 899
A L + Q+LE+D KL+ +N +LQL +N + L S D + + E+++
Sbjct: 1220 AKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDF 1279
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
+ I +L+ QD K + ++ A D L +
Sbjct: 1280 LNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNN 1315
Score = 75.4 bits (177), Expect = 2e-12
Identities = 175/837 (20%), Positives = 329/837 (39%), Gaps = 85/837 (10%)
Query: 312 TTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIE-- 368
TT + + QQ + +L + R E T + EIE EL R + ++E
Sbjct: 350 TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAK 409
Query: 369 --QLRAKLLAAETLCEELMDENEDMKKELRDL---XXXXXXMQDNFREDQADEYS---SL 420
QLR + AA+ EL+++ E+ K+++ DL + + E S L
Sbjct: 410 MDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMEL 469
Query: 421 RRELEQTIKNCRVLSFKLKKTERKAD-----QLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
++L ++ L +L+ + D L QE + ++K LE+ QRE I
Sbjct: 470 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEK-LEVT--RTDHQRE--I 524
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP 535
L++ E + + L A K + N SL K K + + S+ +
Sbjct: 525 TSLKEHFGAREETHQKEIKALYTATEKLSKENESL-KSKLEHANKENSDVIALWKSKLET 583
Query: 536 AQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETV 595
A + Q E + + L E A K LD Q +N+ + +SE
Sbjct: 584 A-IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ--NQQDSERA 640
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPL---SIDKTTEETQFHFDLPYLSIFN-HMAANNLR 651
++ + + + A KEK +S +DK ++ + + + L
Sbjct: 641 AHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE 700
Query: 652 KTAARVEE-----DN--------ESLLLQL---KKMATKARS--RKLSPTPPANKLSIET 693
A+ E DN E LL L +K +++ +S +KL A + I+
Sbjct: 701 VLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH 760
Query: 694 ANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT 753
E+ +A + L+ E + T L+ + E+ Q KE L+K+++ L K + +
Sbjct: 761 LEIEKNAESSKASSITRE--LQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 818
Query: 754 KTSAGSNTTARRSLTTNSNKL--AEERVKVLEDEIDEVRKKLIEKE---RDCERLHAELS 808
+ + + +RS+ NKL EE+ +L +++++R+ L + E R+ + +L
Sbjct: 819 EEA----VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 874
Query: 809 LAQKKPKTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK 866
A++K + I + D Q + +L++ E++ L+ K L NE K
Sbjct: 875 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK---LTKANENASFLQK 931
Query: 867 KLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEAT 926
++ + +A + ++ +LE +L + K++ CQ+ K+ + +E
Sbjct: 932 SIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETK 991
Query: 927 KKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTK 986
K + L++ Q L+ L+ A+K+
Sbjct: 992 TKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKA--------------- 1036
Query: 987 LQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKT--KLEKEIDEIRSKLSKNDSEFTNE 1044
+ + ED +I E K L+ E T +T KL+ E+D ++ KN E
Sbjct: 1037 -KAAQTAED-AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1094
Query: 1045 KNRLQTEIAKLKDVNAKLEGDKDVFANK---YKALENENSNLSNQCKTLTEEMKNRE 1098
K L E K+++ ++E K A K AL+ EN L+ + +E+ + +
Sbjct: 1095 KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ 1151
Score = 62.1 bits (144), Expect = 2e-08
Identities = 203/1078 (18%), Positives = 412/1078 (38%), Gaps = 71/1078 (6%)
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
A++ A+R A+ K + S SL + + SR S T G E ++ R +
Sbjct: 289 AKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRT-GLLTETSSRYARKI 347
Query: 543 QDSLEREADLREQLRNAE----EETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
+ + L+E+ ++ E E +V T ++ + + D H+ +
Sbjct: 348 SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELE 407
Query: 599 IQNKMIHAASTPSSKEKSDS-PPLSIDKT-TEETQFHFDLPYLSIFNHMAANNLRKTAAR 656
+ + + +EK + L +K E+ QF + ++ + A K+ R
Sbjct: 408 AKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKS--R 465
Query: 657 VEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
+ E + L L+++++A R +L PA + + + + E ++++
Sbjct: 466 IMELEKDLALRVQEVAELRR--RLESNKPAGDVDMSLSLLQEISSLQE----KLEVTRTD 519
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
+++E T L+ E +E +K++K L + ++K + + + NS+ +A
Sbjct: 520 HQREITSLK---EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIAL 576
Query: 777 ERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ 836
+ K LE I ++ + E + + + + KT I+ LD Q ++
Sbjct: 577 WKSK-LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDY--QHEIE---N 630
Query: 837 LQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
LQ Q+ S A + +EA KL K+ + A + DKA D + + N+
Sbjct: 631 LQ--NQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 688
Query: 897 LKEALAKIKELEMICQDEKSEKKV--RFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
L+EA K+KELE++ + KV FT K + L
Sbjct: 689 LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR 748
Query: 955 XXXQATLKSLKD-DAQKSFKPRIPKKPTDLTTKLQ-----LKKMVEDLECEIGEMYVVMK 1008
+A K +K + +K+ + K + +T +LQ L + E+L E+ ++ ++
Sbjct: 749 QQLEAAEKQIKHLEIEKNAE---SSKASSITRELQGRELKLTNLQENLS-EVSQVKETLE 804
Query: 1009 NAGLSGKEMTAK-----TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
KE A+ +++ + E +KL + + +F N L +++ KL++ A +E
Sbjct: 805 KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF----NMLSSDLEKLRENLADME 860
Query: 1064 GDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD--LKNATSLQTTMSDC 1121
+ + L L N + + + +Q+ K++ + LK + +
Sbjct: 861 AKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLT 920
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
Q + K +++K +L +++ D KK+
Sbjct: 921 KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELK 980
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
+R + T+ + + + A R + L E +EL+ + K +
Sbjct: 981 ARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA---REENSGLLQELEELRKQAEKAK 1037
Query: 1242 SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK-QLE-DALRQTTNDKYDEATSPVE 1299
+ T E M+ ++ + K +L S K + K Q E D L++ +E E
Sbjct: 1038 AA-QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1096
Query: 1300 MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK-LENXXXX 1358
++ + + E+ K + + SA + E +L +L + +
Sbjct: 1097 LLTVE------NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH 1150
Query: 1359 XXXXXXXXXXXSSYWENKAKE--LDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKL 1416
+ E K +E D E+ L + + KDAEL L+ ++
Sbjct: 1151 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1210
Query: 1417 KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEE-HVVTKAR 1475
+L + A AK + + Q E KLE L ++ E + K +L + T+A
Sbjct: 1211 TVL-RGENASAKSLHSVVQTLESDKVKLE--LKVKNLELQLKENKRQLSSSSGNTDTQAD 1267
Query: 1476 LTVEKEQAQGELLH-VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQER 1532
+++Q + L+ V +L ++K E + AA N ++ N + QE+
Sbjct: 1268 EDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM--SEAALNGNGDDLNNYDSDDQEK 1323
Score = 62.1 bits (144), Expect = 2e-08
Identities = 155/799 (19%), Positives = 290/799 (36%), Gaps = 70/799 (8%)
Query: 1018 TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
TA KL KE + ++SKL E N++N IA K +KLE A+ +A+E
Sbjct: 547 TATEKLSKENESLKSKL-----EHANKEN--SDVIALWK---SKLE---TAIASHQQAME 593
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ S T T E + QI K+ D ++ D
Sbjct: 594 ELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD--SERAAHAKEMEALRA 651
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE--KQLSTRK 1195
+ +N ++ ++KL K ++ D K +E + +
Sbjct: 652 KLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQ 709
Query: 1196 DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLK 1255
+V + ++ + R+ S E SE +L+ + E + LE E K
Sbjct: 710 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE----K 765
Query: 1256 ADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXX 1315
+K +S+ + +++ + L++ L + + K T E+ ++
Sbjct: 766 NAESSKASSITRELQGRELKLTNLQENLSEVSQVK---ETLEKELQILKEKFAEASEEAV 822
Query: 1316 XXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
Q + KL + E + + ++ +L+ +LA +E EN
Sbjct: 823 SVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN 882
Query: 1376 KAKEL---DTDLQSERKKL-DRMRIAHDKDVKNKDAELATLKGKLKIL-----------E 1420
E+ D S+ K+ D +R+ ++DV+ +L L E
Sbjct: 883 DIAEIMKMSGDNSSQLTKMNDELRLK-ERDVEELQLKLTKANENASFLQKSIEDMTVKAE 941
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEK 1480
Q+ AK+ E K+E E + LE + + +EL +YE E TK +
Sbjct: 942 QSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSE---TKTKHEEIL 998
Query: 1481 EQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEV 1540
+ Q LL + +L A E L ++L E EK + + + +
Sbjct: 999 QNLQKTLLDTEDKLKGAREENSGLLQEL--EELRKQAEKAKAAQTAEDAMQIM--EQMTK 1054
Query: 1541 ERARLNARL-DQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXX 1599
E+ A L D ++ + N+ + E++ + +++ + ++
Sbjct: 1055 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIET 1114
Query: 1600 XXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERD 1659
Q E + AE ++ RDE+ S H ++ R +
Sbjct: 1115 LKQAAAQKSQQLSAL--QEENVKLAE----------ELGRSRDEVTS-HQKLEEERSVLN 1161
Query: 1660 NYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDE--EEYRNKVALLEQQVACLEDELCE 1717
N Q+LE ++ IK+ D+ + SIS T E ++ L +V L E
Sbjct: 1162 N--QLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS 1219
Query: 1718 SRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKE 1777
++ L S + T L S+K E+++ ++ +L E +R LSS A E A +
Sbjct: 1220 AKSLHSVVQT-LESDKVKLELKVKNLELQLK--ENKRQLSSSSGNTDTQADEDERAQESQ 1276
Query: 1778 RDEQQRLLQETSTLARDLR 1796
D ++ + +DL+
Sbjct: 1277 IDFLNSVIVDLQRKNQDLK 1295
Score = 50.0 bits (114), Expect = 8e-05
Identities = 98/569 (17%), Positives = 222/569 (39%), Gaps = 36/569 (6%)
Query: 1251 MRDLKADYENKI---TSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXX 1307
+ + + Y KI T+L+ + K HI+QL A R + +ATS V +E
Sbjct: 336 LTETSSRYARKISGTTALQEALKEKQQHIEQLL-AERDLERAEVAKATSHVGEIEQELAL 394
Query: 1308 XXXXXXXXXXQDE--LNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXX 1365
+ E ++ + +E + E ++ + K + L+
Sbjct: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
Query: 1366 XXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGA 1425
+ +++ EL+ DL +++ +R + + D +++ L +L++ S
Sbjct: 455 LEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMS-----LSLLQEISSL 509
Query: 1426 GAK-RITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ 1484
K +T + E T K EH A E+ +E+ Y E +L+ E E +
Sbjct: 510 QEKLEVTRTDHQREITSLK-EHFGAREETHQKEIKALYTATE--------KLSKENESLK 560
Query: 1485 GELLHVQKELSTALGEIKT-LQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA 1543
+L H KE S + K+ L+ + + A K + + ++E+
Sbjct: 561 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKM 620
Query: 1544 RLNARLD----QRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXX 1599
RL+ + + Q +++ A +++ ++ K +
Sbjct: 621 RLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLV 680
Query: 1600 XXXXXXXXXXXXXXXIEQSE--KARKAEITDTKTRYEGQMNTMRD---ELKSLHNQVSRF 1654
+++ E +A+ E T + Q+ + +L +L S
Sbjct: 681 EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG 740
Query: 1655 RRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQ---QVACL 1711
+ E +Q LEAA+K + ++ +K+A + S + + + K+ L++ +V+ +
Sbjct: 741 KSEMKKLRQQLEAAEKQIKHLEI-EKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799
Query: 1712 EDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRM 1770
++ L + + + E E S + + E ++L++ EE+ +LSS ++ M
Sbjct: 800 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM 859
Query: 1771 ELAWHKERDEQQRLLQETSTLARDLRQTL 1799
E + ++ + +++L++ L D+ + +
Sbjct: 860 EAKFREKDEREEQLIKAKEKLENDIAEIM 888
Score = 41.5 bits (93), Expect = 0.030
Identities = 105/615 (17%), Positives = 249/615 (40%), Gaps = 60/615 (9%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E+ + + +Q +E ++ + R++ S+ K + K R + E + + + L K
Sbjct: 708 EQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE--AAEKQIKHLEIEK 765
Query: 227 NSRNS--TNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQI-EGLKQEVDIL 283
N+ +S +++ ++G ++ ++ +++ E ++ V +
Sbjct: 766 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 825
Query: 284 RKRCERVEK--EKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKK 341
R E V K +K + ++++ + ++ + ++ +L E L ++
Sbjct: 826 RSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA 885
Query: 342 HLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXX 400
+ + + S+L + + R +E+L+ KL A L EDM +
Sbjct: 886 EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 945
Query: 401 XXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEH-EKKL 459
+ +++ + S L +++E + C+ L + ++ + +E ++ +K L
Sbjct: 946 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005
Query: 460 LEIVGGPDGMQRENR--IKELEQ--------EVARSTEVALRLQRELA------------ 497
L+ G + EN ++ELE+ + A++ E A+++ ++
Sbjct: 1006 LDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1065
Query: 498 --EANSKFTGSNPSLMK--VPQPETVKVSRSSLT-RGGSQEDPAQLLRDL-----QDSLE 547
+ N+K +L + + E + S+ LT E+ + + L Q S +
Sbjct: 1066 TKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1125
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQ--VMTDNIVTCDIHESETVTNSIQNKMIH 605
A E ++ AEE + +V L+++ V+ + ++ ES+ + ++ + K
Sbjct: 1126 LSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK--- 1182
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
AS K S + L +K E + ++ L N +A +L +E D L
Sbjct: 1183 -ASL--QKSISITSALLTEKDAELEKLRNEVTVLRGEN-ASAKSLHSVVQTLESDKVKLE 1238
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
L++K + + + NK + +++ N + + DE + A+ + LN L+
Sbjct: 1239 LKVKNLELQLKE---------NKRQLSSSSGNTDTQADEDERAQESQIDFLN-SVIVDLQ 1288
Query: 726 RKVEELEQDKEALKK 740
RK ++L+ E + +
Sbjct: 1289 RKNQDLKMKVEMMSE 1303
>BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with
coiled-coil domains and ankyrin repeats protein.
Length = 1416
Score = 85.4 bits (202), Expect = 2e-15
Identities = 176/885 (19%), Positives = 377/885 (42%), Gaps = 89/885 (10%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E LK+E++ +R CE ++++ +L N + A+K ++ L+ ++ +
Sbjct: 440 EILKKELEAMRTFCESAKQDRL-----KLQN-ELAHKVAECKAL-ALECERVKEDSDEQI 492
Query: 334 EDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE-TLCEELMDENEDMK 392
+ L D K + +++ E E +++ + + E L ++ + L EEL D+ +D+K
Sbjct: 493 KQLEDALKDVQKRMYESEGKVKQMQTHFLALK--EHLTSEAASGNHRLTEELKDQLKDLK 550
Query: 393 KELRDLXXXXXXMQDNFREDQ--ADEYS----SLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ +++ ++++ +E+ L E ++ K + + +K RK
Sbjct: 551 VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVT 610
Query: 447 QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGS 506
++E + E KL + + EN L EV + + ++RE ++ S+
Sbjct: 611 EMEGQAKELSAKLALSIPAE---KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQL 667
Query: 507 NPSL--MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETA 564
L +K + VK + ++ +L + + + + L++++ +
Sbjct: 668 KRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNK 727
Query: 565 NCK-QVNPPTFLDKQVMTDNIVTCDIHES-ETVTNSIQNKMIHAASTPSSKEKS------ 616
K Q + T K V+ D+ +S + + + + K++ + K+
Sbjct: 728 LLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLL 787
Query: 617 DSPPLSIDKTTEETQF----HFDLPYLSIFNHMAA--NNLRKTAARVEEDNESL--LLQL 668
++ LS D + ET F + +++ +++ L + + ED E + L
Sbjct: 788 ENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSE 847
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
K S + P ++ + T ND K E ++K E QE ++ K
Sbjct: 848 NTNLKKMMSNQYVPVKTHEEVKM-TLNDTLAKTNREL--LDVKKKFEDINQEFVKIKDKN 904
Query: 729 EELEQDKEALKKQVK-ELTSKISSVTKTSAGSNTTARRSLTTNSNKLA-----EERVKVL 782
E L+++ E + Q+K E S K S+ S + R+ +N+ LA +E + L
Sbjct: 905 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM-RKVQDSNAEILANYRKGQEEIVTL 963
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQ 842
EI + +KK ++ ++C ++ ++ ++ + R A++++ LK QL Q
Sbjct: 964 HAEI-KAQKKELDTIQECIKVKYAPIVSFEECE-----RKFKATEKE---LKDQLSEQTQ 1014
Query: 843 EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN---TKKTTQLENELKE 899
+ SV + + + +N+KL+ E LQ K++ +K+ ++ ++KT +L +LK+
Sbjct: 1015 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD 1074
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
K E++ + K + E K+T + + Q
Sbjct: 1075 LSQKYTEVKNV--------KEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1126
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS-GKEMT 1018
T+++LK++ KS + R +K TKL +++E+ KN+ + + +
Sbjct: 1127 TIENLKEEL-KSMQ-RCYEKEQQTVTKLH--QLLEN-----------QKNSSVPLAEHLQ 1171
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
K EKE+ I++ L + + E N E ++LQ+E+ K KLE + V +KYKA
Sbjct: 1172 IKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKA 1231
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+ S+L Q +L E++ N + ++ ++ +A + + D
Sbjct: 1232 TK---SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1273
Score = 63.7 bits (148), Expect = 6e-09
Identities = 188/1031 (18%), Positives = 403/1031 (39%), Gaps = 89/1031 (8%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISS--VTKTSAGSNTTARRSLTTNSNKLA 775
E E L+ ++ +++Q++ L +V L +++ + S +SL K
Sbjct: 300 EIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQH 359
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
EE ++ +E ++ + K + + L + + +K L+K + +D Q
Sbjct: 360 EESLRTIE----ALKNRF--KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS--P 411
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT-QLE 894
+ Q S+LR SL + QT + ++LK K L + + + K+ +L+
Sbjct: 412 GIPAHMQSRSMLRPLELSLPS-----QTSYSENEILK--KELEAMRTFCESAKQDRLKLQ 464
Query: 895 NELKEALAKIKELEMICQ--DEKSEKKVRFTEATKKETDTL------KSKQXXXXXXXXX 946
NEL +A+ K L + C+ E S+++++ E K+ K KQ
Sbjct: 465 NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK 524
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL-TTKLQLKK---MVEDLECEIGE 1002
+ LKD K K + ++ + Q+K+ +VE+ + + G+
Sbjct: 525 EHLTSEAASGNHRLTEELKDQL-KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGK 583
Query: 1003 MYV----VMKNAGLSGKEMTAK----TKLEKEIDEIRSKLSKN--DSEFTNEKNRLQTEI 1052
+ + K + E K T++E + E+ +KL+ + +F N K+ L E+
Sbjct: 584 LIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEV 643
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
+ ++E + + ++ + L+ E N+ + L + +K E + K + K+
Sbjct: 644 NEKAKKLVEMEREHEKSLSEIRQLKRELENVKAK---LAQHVKPEEHEQVKSRLEQKSG- 699
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD 1172
L +++ Q N T I+ + + +V + KK D
Sbjct: 700 ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLT-IEMKNHYVPLKVSEDMKKSHD 758
Query: 1173 XXXXXXXXXX---XCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV-VLANTHRRLSIELTS 1228
K EK+L K + + V V H + I L S
Sbjct: 759 AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
EL+ + + + K + ++ L + EN T+L+ ++ + V +K E+ ++ T N
Sbjct: 819 NIVELKKQLSELKKKCGEDQEKIHALTS--EN--TNLKKMMSNQYVPVKTHEE-VKMTLN 873
Query: 1289 DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
D A + E+++++ +D+ K LE T+ + A + +A+ ++
Sbjct: 874 DTL--AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAK 931
Query: 1349 LAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAE 1408
++ L + + L ++++++K+LD ++ + +K K A
Sbjct: 932 MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ----ECIKVKYAP 987
Query: 1409 LATLKGKLKILEQNSGAGAKRITELKQEY---EETVKKLEHSLALEKAEY----EELTGK 1461
+ + + + + +++E Q+Y EE VKK + K E ++L K
Sbjct: 988 IVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDK 1047
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
L+E+ H + +A L+ + ++ +L K+LS E+K ++EKL E+A +E
Sbjct: 1048 TVLIEKSHEMERA-LSRKTDELNKQL----KDLSQKYTEVKNVKEKLVEENAKQTSEILA 1102
Query: 1522 MQN----------SIASLQERLCGGGWEVERARLNARLDQR--ERELRAANDRRDVLEHH 1569
+QN + +L++ L G +E + + QR E+E + +LE+
Sbjct: 1103 VQNLLQKQHVPLEQVEALKKSLNG---TIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ 1159
Query: 1570 HDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDT 1629
+ +E+ I + ++ + K +
Sbjct: 1160 KNSSVPLAEHLQIKEA-FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1218
Query: 1630 KTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSI 1689
+TR ++ + L Q+S + N + E + + K + SA+ + +
Sbjct: 1219 ETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL 1278
Query: 1690 SSTDEEEYRNK 1700
+ E+E +++
Sbjct: 1279 HFSIEQEIKDQ 1289
Score = 56.4 bits (130), Expect = 1e-06
Identities = 171/969 (17%), Positives = 357/969 (36%), Gaps = 68/969 (7%)
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEAD-NEK------LQTENKKLQLLKNAKSLRSDK 881
+N DLK +L+ I+QE +L K L+ NE+ L++E +KL+ L AK + ++
Sbjct: 302 ENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEE 361
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
+L + + + L +D ++ + ++ + + +
Sbjct: 362 SLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ + + +A ++F + L +L K V + +
Sbjct: 422 MLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHK--VAECKALAL 479
Query: 1002 EMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VN 1059
E V +++ K++ K ++K + E K+ + + F K L +E A +
Sbjct: 480 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 539
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKT---LTEEMKNREAQINKLSADLKNATSLQT 1116
+L+ KY+ E L NQ K + EE K E ++ + + L+ S+
Sbjct: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + K + K+ L EV +K KK+ +
Sbjct: 600 MEREKKGRKVTEMEGQAKELSAKLALSIPAE---KFENMKSSLSNEVNEKAKKLVEMERE 656
Query: 1177 XXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR--RLSIELTSEKDELQ 1234
++++++L K ++ ++ + + + ELT + LQ
Sbjct: 657 HEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQ 716
Query: 1235 ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN--DKYD 1292
K L+ + +L + +N L+ + K H ++D R+ + KY
Sbjct: 717 KEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYT 776
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
E +E + + L + EK E E A K + +LK L++L
Sbjct: 777 EKKLEMEKLLLENDSLSKDVS------RLETVFVPPEKHEKEIIALKSNIVELKKQLSEL 830
Query: 1353 ENX---------XXXXXXXXXXXXXXSSYWENKA-KELDTDLQSERKKLDRMRIAHDKDV 1402
+ + Y K +E+ L K +R + K
Sbjct: 831 KKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 890
Query: 1403 KNKDAELATLKGKLKILEQNSGAGAKRITE---LKQEYEETVKKLEHSLALEKAEYEELT 1459
++ + E +K K +IL++N +I E+E + L S+ + E+
Sbjct: 891 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 950
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
Y +EE V A + +K+ EL +Q+ + I + +E E TEK
Sbjct: 951 ANYRKGQEEIVTLHAEIKAQKK----ELDTIQECIKVKYAPIVSFEE---CERKFKATEK 1003
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL-NARLDQRERELRA-ANDRRDVLEHHHDXXXXXX 1577
E+++ ++ ++ EV++ + N +L + L+ D+ ++E H+
Sbjct: 1004 -ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1062
Query: 1578 XXXXXXXXDYERVS------KIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
+ +S K + + Q + ++ K
Sbjct: 1063 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKK 1122
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKS---MAE---IKNG-DKSARI 1684
G + +++ELKS+ + ++ Q+LE + S +AE IK +K I
Sbjct: 1123 SLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1182
Query: 1685 HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
+ S+ EEE +NK+ ++V+ L+ E+ ++ KL T V + S + ++++
Sbjct: 1183 IKASLRE-KEEESQNKM----EEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
Query: 1745 SRLNEYEEE 1753
++++ E+
Sbjct: 1238 TQISSLNEK 1246
>BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with
coiled-coil domains and ankyrin repeats protein.
Length = 1416
Score = 85.4 bits (202), Expect = 2e-15
Identities = 176/885 (19%), Positives = 377/885 (42%), Gaps = 89/885 (10%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E LK+E++ +R CE ++++ +L N + A+K ++ L+ ++ +
Sbjct: 440 EILKKELEAMRTFCESAKQDRL-----KLQN-ELAHKVAECKAL-ALECERVKEDSDEQI 492
Query: 334 EDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE-TLCEELMDENEDMK 392
+ L D K + +++ E E +++ + + E L ++ + L EEL D+ +D+K
Sbjct: 493 KQLEDALKDVQKRMYESEGKVKQMQTHFLALK--EHLTSEAASGNHRLTEELKDQLKDLK 550
Query: 393 KELRDLXXXXXXMQDNFREDQ--ADEYS----SLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ +++ ++++ +E+ L E ++ K + + +K RK
Sbjct: 551 VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVT 610
Query: 447 QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGS 506
++E + E KL + + EN L EV + + ++RE ++ S+
Sbjct: 611 EMEGQAKELSAKLALSIPAE---KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQL 667
Query: 507 NPSL--MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETA 564
L +K + VK + ++ +L + + + + L++++ +
Sbjct: 668 KRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNK 727
Query: 565 NCK-QVNPPTFLDKQVMTDNIVTCDIHES-ETVTNSIQNKMIHAASTPSSKEKS------ 616
K Q + T K V+ D+ +S + + + + K++ + K+
Sbjct: 728 LLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLL 787
Query: 617 DSPPLSIDKTTEETQF----HFDLPYLSIFNHMAA--NNLRKTAARVEEDNESL--LLQL 668
++ LS D + ET F + +++ +++ L + + ED E + L
Sbjct: 788 ENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSE 847
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
K S + P ++ + T ND K E ++K E QE ++ K
Sbjct: 848 NTNLKKMMSNQYVPVKTHEEVKM-TLNDTLAKTNREL--LDVKKKFEDINQEFVKIKDKN 904
Query: 729 EELEQDKEALKKQVK-ELTSKISSVTKTSAGSNTTARRSLTTNSNKLA-----EERVKVL 782
E L+++ E + Q+K E S K S+ S + R+ +N+ LA +E + L
Sbjct: 905 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM-RKVQDSNAEILANYRKGQEEIVTL 963
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQ 842
EI + +KK ++ ++C ++ ++ ++ + R A++++ LK QL Q
Sbjct: 964 HAEI-KAQKKELDTIQECIKVKYAPIVSFEECE-----RKFKATEKE---LKDQLSEQTQ 1014
Query: 843 EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN---TKKTTQLENELKE 899
+ SV + + + +N+KL+ E LQ K++ +K+ ++ ++KT +L +LK+
Sbjct: 1015 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD 1074
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
K E++ + K + E K+T + + Q
Sbjct: 1075 LSQKYTEVKNV--------KEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1126
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS-GKEMT 1018
T+++LK++ KS + R +K TKL +++E+ KN+ + + +
Sbjct: 1127 TIENLKEEL-KSMQ-RCYEKEQQTVTKLH--QLLEN-----------QKNSSVPLAEHLQ 1171
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
K EKE+ I++ L + + E N E ++LQ+E+ K KLE + V +KYKA
Sbjct: 1172 IKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKA 1231
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+ S+L Q +L E++ N + ++ ++ +A + + D
Sbjct: 1232 TK---SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1273
Score = 63.7 bits (148), Expect = 6e-09
Identities = 188/1031 (18%), Positives = 403/1031 (39%), Gaps = 89/1031 (8%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISS--VTKTSAGSNTTARRSLTTNSNKLA 775
E E L+ ++ +++Q++ L +V L +++ + S +SL K
Sbjct: 300 EIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQH 359
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
EE ++ +E ++ + K + + L + + +K L+K + +D Q
Sbjct: 360 EESLRTIE----ALKNRF--KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS--P 411
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT-QLE 894
+ Q S+LR SL + QT + ++LK K L + + + K+ +L+
Sbjct: 412 GIPAHMQSRSMLRPLELSLPS-----QTSYSENEILK--KELEAMRTFCESAKQDRLKLQ 464
Query: 895 NELKEALAKIKELEMICQ--DEKSEKKVRFTEATKKETDTL------KSKQXXXXXXXXX 946
NEL +A+ K L + C+ E S+++++ E K+ K KQ
Sbjct: 465 NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK 524
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL-TTKLQLKK---MVEDLECEIGE 1002
+ LKD K K + ++ + Q+K+ +VE+ + + G+
Sbjct: 525 EHLTSEAASGNHRLTEELKDQL-KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGK 583
Query: 1003 MYV----VMKNAGLSGKEMTAK----TKLEKEIDEIRSKLSKN--DSEFTNEKNRLQTEI 1052
+ + K + E K T++E + E+ +KL+ + +F N K+ L E+
Sbjct: 584 LIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEV 643
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
+ ++E + + ++ + L+ E N+ + L + +K E + K + K+
Sbjct: 644 NEKAKKLVEMEREHEKSLSEIRQLKRELENVKAK---LAQHVKPEEHEQVKSRLEQKSG- 699
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD 1172
L +++ Q N T I+ + + +V + KK D
Sbjct: 700 ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLT-IEMKNHYVPLKVSEDMKKSHD 758
Query: 1173 XXXXXXXXXX---XCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV-VLANTHRRLSIELTS 1228
K EK+L K + + V V H + I L S
Sbjct: 759 AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
EL+ + + + K + ++ L + EN T+L+ ++ + V +K E+ ++ T N
Sbjct: 819 NIVELKKQLSELKKKCGEDQEKIHALTS--EN--TNLKKMMSNQYVPVKTHEE-VKMTLN 873
Query: 1289 DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
D A + E+++++ +D+ K LE T+ + A + +A+ ++
Sbjct: 874 DTL--AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAK 931
Query: 1349 LAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAE 1408
++ L + + L ++++++K+LD ++ + +K K A
Sbjct: 932 MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ----ECIKVKYAP 987
Query: 1409 LATLKGKLKILEQNSGAGAKRITELKQEY---EETVKKLEHSLALEKAEY----EELTGK 1461
+ + + + + +++E Q+Y EE VKK + K E ++L K
Sbjct: 988 IVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDK 1047
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
L+E+ H + +A L+ + ++ +L K+LS E+K ++EKL E+A +E
Sbjct: 1048 TVLIEKSHEMERA-LSRKTDELNKQL----KDLSQKYTEVKNVKEKLVEENAKQTSEILA 1102
Query: 1522 MQN----------SIASLQERLCGGGWEVERARLNARLDQR--ERELRAANDRRDVLEHH 1569
+QN + +L++ L G +E + + QR E+E + +LE+
Sbjct: 1103 VQNLLQKQHVPLEQVEALKKSLNG---TIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ 1159
Query: 1570 HDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDT 1629
+ +E+ I + ++ + K +
Sbjct: 1160 KNSSVPLAEHLQIKEA-FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1218
Query: 1630 KTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSI 1689
+TR ++ + L Q+S + N + E + + K + SA+ + +
Sbjct: 1219 ETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL 1278
Query: 1690 SSTDEEEYRNK 1700
+ E+E +++
Sbjct: 1279 HFSIEQEIKDQ 1289
Score = 56.4 bits (130), Expect = 1e-06
Identities = 171/969 (17%), Positives = 357/969 (36%), Gaps = 68/969 (7%)
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEAD-NEK------LQTENKKLQLLKNAKSLRSDK 881
+N DLK +L+ I+QE +L K L+ NE+ L++E +KL+ L AK + ++
Sbjct: 302 ENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEE 361
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
+L + + + L +D ++ + ++ + + +
Sbjct: 362 SLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ + + +A ++F + L +L K V + +
Sbjct: 422 MLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHK--VAECKALAL 479
Query: 1002 EMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VN 1059
E V +++ K++ K ++K + E K+ + + F K L +E A +
Sbjct: 480 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 539
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKT---LTEEMKNREAQINKLSADLKNATSLQT 1116
+L+ KY+ E L NQ K + EE K E ++ + + L+ S+
Sbjct: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + K + K+ L EV +K KK+ +
Sbjct: 600 MEREKKGRKVTEMEGQAKELSAKLALSIPAE---KFENMKSSLSNEVNEKAKKLVEMERE 656
Query: 1177 XXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR--RLSIELTSEKDELQ 1234
++++++L K ++ ++ + + + ELT + LQ
Sbjct: 657 HEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQ 716
Query: 1235 ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN--DKYD 1292
K L+ + +L + +N L+ + K H ++D R+ + KY
Sbjct: 717 KEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYT 776
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
E +E + + L + EK E E A K + +LK L++L
Sbjct: 777 EKKLEMEKLLLENDSLSKDVS------RLETVFVPPEKHEKEIIALKSNIVELKKQLSEL 830
Query: 1353 ENX---------XXXXXXXXXXXXXXSSYWENKA-KELDTDLQSERKKLDRMRIAHDKDV 1402
+ + Y K +E+ L K +R + K
Sbjct: 831 KKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 890
Query: 1403 KNKDAELATLKGKLKILEQNSGAGAKRITE---LKQEYEETVKKLEHSLALEKAEYEELT 1459
++ + E +K K +IL++N +I E+E + L S+ + E+
Sbjct: 891 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 950
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
Y +EE V A + +K+ EL +Q+ + I + +E E TEK
Sbjct: 951 ANYRKGQEEIVTLHAEIKAQKK----ELDTIQECIKVKYAPIVSFEE---CERKFKATEK 1003
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL-NARLDQRERELRA-ANDRRDVLEHHHDXXXXXX 1577
E+++ ++ ++ EV++ + N +L + L+ D+ ++E H+
Sbjct: 1004 -ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1062
Query: 1578 XXXXXXXXDYERVS------KIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
+ +S K + + Q + ++ K
Sbjct: 1063 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKK 1122
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKS---MAE---IKNG-DKSARI 1684
G + +++ELKS+ + ++ Q+LE + S +AE IK +K I
Sbjct: 1123 SLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1182
Query: 1685 HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
+ S+ EEE +NK+ ++V+ L+ E+ ++ KL T V + S + ++++
Sbjct: 1183 IKASLRE-KEEESQNKM----EEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
Query: 1745 SRLNEYEEE 1753
++++ E+
Sbjct: 1238 TQISSLNEK 1246
>AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein.
Length = 1416
Score = 85.4 bits (202), Expect = 2e-15
Identities = 176/885 (19%), Positives = 377/885 (42%), Gaps = 89/885 (10%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E LK+E++ +R CE ++++ +L N + A+K ++ L+ ++ +
Sbjct: 440 EILKKELEAMRTFCESAKQDRL-----KLQN-ELAHKVAECKAL-ALECERVKEDSDEQI 492
Query: 334 EDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE-TLCEELMDENEDMK 392
+ L D K + +++ E E +++ + + E L ++ + L EEL D+ +D+K
Sbjct: 493 KQLEDALKDVQKRMYESEGKVKQMQTHFLALK--EHLTSEAASGNHRLTEELKDQLKDLK 550
Query: 393 KELRDLXXXXXXMQDNFREDQ--ADEYS----SLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ +++ ++++ +E+ L E ++ K + + +K RK
Sbjct: 551 VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVT 610
Query: 447 QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGS 506
++E + E KL + + EN L EV + + ++RE ++ S+
Sbjct: 611 EMEGQAKELSAKLALSIPAE---KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQL 667
Query: 507 NPSL--MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETA 564
L +K + VK + ++ +L + + + + L++++ +
Sbjct: 668 KRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNK 727
Query: 565 NCK-QVNPPTFLDKQVMTDNIVTCDIHES-ETVTNSIQNKMIHAASTPSSKEKS------ 616
K Q + T K V+ D+ +S + + + + K++ + K+
Sbjct: 728 LLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLL 787
Query: 617 DSPPLSIDKTTEETQF----HFDLPYLSIFNHMAA--NNLRKTAARVEEDNESL--LLQL 668
++ LS D + ET F + +++ +++ L + + ED E + L
Sbjct: 788 ENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSE 847
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
K S + P ++ + T ND K E ++K E QE ++ K
Sbjct: 848 NTNLKKMMSNQYVPVKTHEEVKM-TLNDTLAKTNREL--LDVKKKFEDINQEFVKIKDKN 904
Query: 729 EELEQDKEALKKQVK-ELTSKISSVTKTSAGSNTTARRSLTTNSNKLA-----EERVKVL 782
E L+++ E + Q+K E S K S+ S + R+ +N+ LA +E + L
Sbjct: 905 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM-RKVQDSNAEILANYRKGQEEIVTL 963
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQ 842
EI + +KK ++ ++C ++ ++ ++ + R A++++ LK QL Q
Sbjct: 964 HAEI-KAQKKELDTIQECIKVKYAPIVSFEECE-----RKFKATEKE---LKDQLSEQTQ 1014
Query: 843 EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN---TKKTTQLENELKE 899
+ SV + + + +N+KL+ E LQ K++ +K+ ++ ++KT +L +LK+
Sbjct: 1015 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD 1074
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
K E++ + K + E K+T + + Q
Sbjct: 1075 LSQKYTEVKNV--------KEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1126
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS-GKEMT 1018
T+++LK++ KS + R +K TKL +++E+ KN+ + + +
Sbjct: 1127 TIENLKEEL-KSMQ-RCYEKEQQTVTKLH--QLLEN-----------QKNSSVPLAEHLQ 1171
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
K EKE+ I++ L + + E N E ++LQ+E+ K KLE + V +KYKA
Sbjct: 1172 IKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKA 1231
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+ S+L Q +L E++ N + ++ ++ +A + + D
Sbjct: 1232 TK---SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1273
Score = 63.7 bits (148), Expect = 6e-09
Identities = 188/1031 (18%), Positives = 403/1031 (39%), Gaps = 89/1031 (8%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISS--VTKTSAGSNTTARRSLTTNSNKLA 775
E E L+ ++ +++Q++ L +V L +++ + S +SL K
Sbjct: 300 EIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQH 359
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
EE ++ +E ++ + K + + L + + +K L+K + +D Q
Sbjct: 360 EESLRTIE----ALKNRF--KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS--P 411
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT-QLE 894
+ Q S+LR SL + QT + ++LK K L + + + K+ +L+
Sbjct: 412 GIPAHMQSRSMLRPLELSLPS-----QTSYSENEILK--KELEAMRTFCESAKQDRLKLQ 464
Query: 895 NELKEALAKIKELEMICQ--DEKSEKKVRFTEATKKETDTL------KSKQXXXXXXXXX 946
NEL +A+ K L + C+ E S+++++ E K+ K KQ
Sbjct: 465 NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK 524
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL-TTKLQLKK---MVEDLECEIGE 1002
+ LKD K K + ++ + Q+K+ +VE+ + + G+
Sbjct: 525 EHLTSEAASGNHRLTEELKDQL-KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGK 583
Query: 1003 MYV----VMKNAGLSGKEMTAK----TKLEKEIDEIRSKLSKN--DSEFTNEKNRLQTEI 1052
+ + K + E K T++E + E+ +KL+ + +F N K+ L E+
Sbjct: 584 LIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEV 643
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
+ ++E + + ++ + L+ E N+ + L + +K E + K + K+
Sbjct: 644 NEKAKKLVEMEREHEKSLSEIRQLKRELENVKAK---LAQHVKPEEHEQVKSRLEQKSG- 699
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD 1172
L +++ Q N T I+ + + +V + KK D
Sbjct: 700 ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLT-IEMKNHYVPLKVSEDMKKSHD 758
Query: 1173 XXXXXXXXXX---XCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV-VLANTHRRLSIELTS 1228
K EK+L K + + V V H + I L S
Sbjct: 759 AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
EL+ + + + K + ++ L + EN T+L+ ++ + V +K E+ ++ T N
Sbjct: 819 NIVELKKQLSELKKKCGEDQEKIHALTS--EN--TNLKKMMSNQYVPVKTHEE-VKMTLN 873
Query: 1289 DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
D A + E+++++ +D+ K LE T+ + A + +A+ ++
Sbjct: 874 DTL--AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAK 931
Query: 1349 LAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAE 1408
++ L + + L ++++++K+LD ++ + +K K A
Sbjct: 932 MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ----ECIKVKYAP 987
Query: 1409 LATLKGKLKILEQNSGAGAKRITELKQEY---EETVKKLEHSLALEKAEY----EELTGK 1461
+ + + + + +++E Q+Y EE VKK + K E ++L K
Sbjct: 988 IVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDK 1047
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
L+E+ H + +A L+ + ++ +L K+LS E+K ++EKL E+A +E
Sbjct: 1048 TVLIEKSHEMERA-LSRKTDELNKQL----KDLSQKYTEVKNVKEKLVEENAKQTSEILA 1102
Query: 1522 MQN----------SIASLQERLCGGGWEVERARLNARLDQR--ERELRAANDRRDVLEHH 1569
+QN + +L++ L G +E + + QR E+E + +LE+
Sbjct: 1103 VQNLLQKQHVPLEQVEALKKSLNG---TIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ 1159
Query: 1570 HDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDT 1629
+ +E+ I + ++ + K +
Sbjct: 1160 KNSSVPLAEHLQIKEA-FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1218
Query: 1630 KTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSI 1689
+TR ++ + L Q+S + N + E + + K + SA+ + +
Sbjct: 1219 ETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL 1278
Query: 1690 SSTDEEEYRNK 1700
+ E+E +++
Sbjct: 1279 HFSIEQEIKDQ 1289
Score = 56.4 bits (130), Expect = 1e-06
Identities = 171/969 (17%), Positives = 357/969 (36%), Gaps = 68/969 (7%)
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEAD-NEK------LQTENKKLQLLKNAKSLRSDK 881
+N DLK +L+ I+QE +L K L+ NE+ L++E +KL+ L AK + ++
Sbjct: 302 ENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEE 361
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
+L + + + L +D ++ + ++ + + +
Sbjct: 362 SLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ + + +A ++F + L +L K V + +
Sbjct: 422 MLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHK--VAECKALAL 479
Query: 1002 EMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VN 1059
E V +++ K++ K ++K + E K+ + + F K L +E A +
Sbjct: 480 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 539
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKT---LTEEMKNREAQINKLSADLKNATSLQT 1116
+L+ KY+ E L NQ K + EE K E ++ + + L+ S+
Sbjct: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + K + K+ L EV +K KK+ +
Sbjct: 600 MEREKKGRKVTEMEGQAKELSAKLALSIPAE---KFENMKSSLSNEVNEKAKKLVEMERE 656
Query: 1177 XXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR--RLSIELTSEKDELQ 1234
++++++L K ++ ++ + + + ELT + LQ
Sbjct: 657 HEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQ 716
Query: 1235 ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN--DKYD 1292
K L+ + +L + +N L+ + K H ++D R+ + KY
Sbjct: 717 KEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYT 776
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
E +E + + L + EK E E A K + +LK L++L
Sbjct: 777 EKKLEMEKLLLENDSLSKDVS------RLETVFVPPEKHEKEIIALKSNIVELKKQLSEL 830
Query: 1353 ENX---------XXXXXXXXXXXXXXSSYWENKA-KELDTDLQSERKKLDRMRIAHDKDV 1402
+ + Y K +E+ L K +R + K
Sbjct: 831 KKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 890
Query: 1403 KNKDAELATLKGKLKILEQNSGAGAKRITE---LKQEYEETVKKLEHSLALEKAEYEELT 1459
++ + E +K K +IL++N +I E+E + L S+ + E+
Sbjct: 891 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 950
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
Y +EE V A + +K+ EL +Q+ + I + +E E TEK
Sbjct: 951 ANYRKGQEEIVTLHAEIKAQKK----ELDTIQECIKVKYAPIVSFEE---CERKFKATEK 1003
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL-NARLDQRERELRA-ANDRRDVLEHHHDXXXXXX 1577
E+++ ++ ++ EV++ + N +L + L+ D+ ++E H+
Sbjct: 1004 -ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1062
Query: 1578 XXXXXXXXDYERVS------KIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
+ +S K + + Q + ++ K
Sbjct: 1063 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKK 1122
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKS---MAE---IKNG-DKSARI 1684
G + +++ELKS+ + ++ Q+LE + S +AE IK +K I
Sbjct: 1123 SLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1182
Query: 1685 HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
+ S+ EEE +NK+ ++V+ L+ E+ ++ KL T V + S + ++++
Sbjct: 1183 IKASLRE-KEEESQNKM----EEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
Query: 1745 SRLNEYEEE 1753
++++ E+
Sbjct: 1238 TQISSLNEK 1246
>AB209693-1|BAD92930.1| 1310|Homo sapiens golgi autoantigen, golgin
subfamily a, 4 variant protein.
Length = 1310
Score = 85.4 bits (202), Expect = 2e-15
Identities = 220/1151 (19%), Positives = 443/1151 (38%), Gaps = 94/1151 (8%)
Query: 407 DNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL--EQEKAEHEKKLLEIVG 464
D+ ED SL +E Q I+ R + L K +L + + EKK L+ +
Sbjct: 152 DSEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL 209
Query: 465 GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
+ RI EL +E+ + LQ E + SL + Q +V ++
Sbjct: 210 SQSQDKSLRRIAELREELQMDQQAKKHLQEEF----------DASLEEKDQYISVLQTQV 259
Query: 525 SLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI 584
SL + + P + D L+ L Q AE T K+ NP + D + + ++
Sbjct: 260 SLLKQRLRNGPMNV-----DVLKPLPQLEPQ---AEVFT---KEENPES--DGEPVVEDG 306
Query: 585 VTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN- 643
+ E+ Q ++ K L+ +K + Q L L
Sbjct: 307 TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKD 366
Query: 644 -HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKET 702
HMA T R ++ L Q K M R++ T + I ++ T
Sbjct: 367 LHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMT 426
Query: 703 DEADPAEMKLLLELNEQEA-TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+ + E++ E +E+ A L + + ++ +EA +K E+ +I ++ KTS
Sbjct: 427 TQGE--ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERI 484
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKE--RDCERLHAELSLAQKKPKTLIK 819
+ ++ L+ ++ + K E++I +++K L EKE R + L +L +++ + +K
Sbjct: 485 SLQQELSRVKQEVVDVMKKSSEEQIAKLQK-LHEKELARKEQELTKKLQTREREFQEQMK 543
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKNAKSL 877
+L+ S + + + ++ + +QE+ L + LE + + TE NK L + A++
Sbjct: 544 V-ALEKSQSEYLKISQEKE--QQESLAL----EELELQKKAILTESENKLRDLQQEAETY 596
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT---EATKKETDTLK 934
R+ + L+L + LE L+E + K+L + + EK++ T E K E ++LK
Sbjct: 597 RT-RILELESS----LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 651
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL--KKM 992
+Q Q ++ L++ ++ + + K ++ +K
Sbjct: 652 HQQDALWTEKLQVLKQQY-----QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT 706
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI 1052
+E L+ + E+ + ++ LS + + A+ KLE+E+ ++ + K E + + +
Sbjct: 707 LEKLDVKQTELESL--SSELS-EVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH- 762
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
+ V++ ++ + KAL+++ + L K + +K +A + L AD+K +
Sbjct: 763 -HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 821
Query: 1113 -SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIG 1171
LQ + ++ ++ L K+V + +
Sbjct: 822 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 881
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
D + + +QL + + + N + + ++ EK+
Sbjct: 882 DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE 941
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKY 1291
+ + + + K I + + K D +HI E + +K
Sbjct: 942 NMILQMREGQKKEIEILTQKLSAKED---------------SIHILNEEYETKFKNQEKK 986
Query: 1292 DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK 1351
E + EL N ++L + E + +A LEMAQ S A
Sbjct: 987 MEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS--AG 1044
Query: 1352 LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL----DRMRIAHDKDVKNKDA 1407
+ + S E +EL+ + KKL + ++ H+ ++ K+
Sbjct: 1045 ISD--AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1102
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQE---YEETVKKLEHSLALEKAEYEELTGKYEL 1464
E+A LK K+ + K IT LK+E + T+ +L+ L + A L
Sbjct: 1103 EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1162
Query: 1465 LE---EEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
L+ E+ V + E Q +L+ ++ ++ L KL T + + K+
Sbjct: 1163 LKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1222
Query: 1522 MQNSIASLQER 1532
+ S SL+++
Sbjct: 1223 HEKSNKSLEDK 1233
Score = 64.9 bits (151), Expect = 3e-09
Identities = 138/644 (21%), Positives = 278/644 (43%), Gaps = 64/644 (9%)
Query: 154 QTQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEK-ERERRSLSKSKEDEKTARYKD-- 210
+T+L K+ A K+Q+LK Q E E EK E+E+ +L K KE A ++
Sbjct: 644 KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 703
Query: 211 ERSSTKDDVNFL-MQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEY 269
E++ K DV ++ +S S LK + +D +
Sbjct: 704 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 763
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q Q++ + +E ++ +R E+ K++ I+ R + + Q V L
Sbjct: 764 QQQVDSIIKEHEVSIQRTEKALKDQ----------INQLELLLKERDKHLKEHQAHVENL 813
Query: 330 TTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQLRAKLLAAET---LCEELM 385
+ E + + K+ +S + T T+A Q+ QL+ KLL ET L + +
Sbjct: 814 EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 873
Query: 386 DENEDMKKEL-RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN-CRVLSFKLKKTER 443
E E KK++ +L +QD + Q ++ +S E+EQ +K+ +V KL+ +
Sbjct: 874 AEVEAQKKDVCTELDAHKIQVQDLMQ--QLEKQNS---EMEQKVKSLTQVYESKLEDGNK 928
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+ +Q +Q E E +L++ +G ++E I+ L Q+++ + E ++ + E E +KF
Sbjct: 929 EQEQTKQILVEKENMILQM---REGQKKE--IEILTQKLS-AKEDSIHILNE--EYETKF 980
Query: 504 TGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEET 563
+ KV Q ++E L + L L++EA L+++L N E
Sbjct: 981 KNQEKKMEKVKQK--------------AKEMQETLKKKL---LDQEAKLKKELENTALEL 1023
Query: 564 ANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
+ ++ F K + + I ++ + + Q + I + + +E +D +
Sbjct: 1024 SQKEK----QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1079
Query: 624 DKTTEETQFHFDLPYLSI-FNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
K ++ + ++ + + L++ + E + ++ + + + +
Sbjct: 1080 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1139
Query: 683 TPPANKLSIETANDNDEKETDEADPAEM-KLLLELNE--QEATVLRRKVEELEQDKEALK 739
+L ++A+ N + + A + KL ++LN+ +E T L+ ++ EL+ E K
Sbjct: 1140 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1199
Query: 740 KQVKELTSKISSVT---KTSAGSNTTARRSLTTNS---NKLAEE 777
++V ELTSK+ + ++ S+ + +SL S KL+EE
Sbjct: 1200 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1243
Score = 61.3 bits (142), Expect = 3e-08
Identities = 221/1202 (18%), Positives = 456/1202 (37%), Gaps = 92/1202 (7%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ--QKVNELTTHNEDLRDEKK 341
R+ R++ + S +++D+ + G S + K Q Q++ + R +
Sbjct: 130 RESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYS 189
Query: 342 HLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXX 401
L + ++ E + +Q+ Q + LR AE L EEL + + KK L++
Sbjct: 190 ELVTAYQMLQREKKKLQGILSQS-QDKSLRR---IAE-LREELQMDQQ-AKKHLQEEFDA 243
Query: 402 XXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLE 461
+D + + S L++ L N VL L + E +A+ +E+
Sbjct: 244 SLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPESDGEPV 302
Query: 462 IVGGPDGMQREN---RIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL-MKVPQPE 517
+ G E R+K E + R E + + S+ L ++ + E
Sbjct: 303 VEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELE 362
Query: 518 TVK-VSRSSLTRGGSQ-EDPAQLLRDLQDS-----LEREADLREQLRNAEEETANCKQVN 570
+K + + T+ +Q D L+ L+ E + + E L EEE A +
Sbjct: 363 KIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRI 422
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
+ + + + E + ++ + K + D +I+KT+EE
Sbjct: 423 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 482
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ LS + ++K++ E + +L+K+ K +RK +
Sbjct: 483 RISLQQE-LSRVKQEVVDVMKKSS-------EEQIAKLQKLHEKELARKEQELTKKLQTR 534
Query: 691 IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKIS 750
+ + +++ +K+ E +QE+ L EELE K+A+ LT +
Sbjct: 535 EREFQEQMKVALEKSQSEYLKISQEKEQQESLAL----EELELQKKAI------LTESEN 584
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ + T R L +L K L++ ++ + + E + + + E+++
Sbjct: 585 KLRDLQQEAETYRTRIL-----ELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM 639
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
+K KT ++S QQ+ +LQV++Q+ K + ++ ++K++
Sbjct: 640 VEKHKTELES----LKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF 695
Query: 871 LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
+ + + ++K L+ K T+LE+ L L+++ + ++E S K + T+ K+E
Sbjct: 696 QAHIEEM-NEKTLEKLDVKQTELES-LSSELSEVLKARHKLEEELSVLKDQ-TDKMKQEL 752
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
+ K + Q T K+LKD + + K D K + +
Sbjct: 753 EA-KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL---ELLLKERDKHLK-EHQ 807
Query: 991 KMVEDLECEI----GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKN 1046
VE+LE +I GE+ + +A + K +E ++L + + E+
Sbjct: 808 AHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERI 867
Query: 1047 RLQTEIAKL----KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
L ++A++ KDV +L+ K + + LE +NS + + K+LT+ +++ N
Sbjct: 868 LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN 927
Query: 1103 KLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQV--DNYTKIDQDKNKLL 1160
K K + M M + + Y +++ K +
Sbjct: 928 KEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKM 987
Query: 1161 KEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR 1220
++V K K++ + +++K+L ++ + + +A +
Sbjct: 988 EKVKQKAKEMQETLKKKLLDQEA--KLKKEL---ENTALELSQKEKQFNAKMLEMAQANS 1042
Query: 1221 RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE 1280
+ S + Q I ES E+ D+ + +E K+ + +++H QL+
Sbjct: 1043 AGISDAVSRLETNQKEQI--ESLTEVHRRELNDVISIWEKKLNQQAEEL--QEIHEIQLQ 1098
Query: 1281 DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL 1340
+ ++ K E EM LN + +L++ A ++
Sbjct: 1099 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1158
Query: 1341 EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK 1400
+ +LK+ L KLE +++ + + EL + +++K+ +
Sbjct: 1159 DETKLKAHLEKLE-------VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSEL----TS 1207
Query: 1401 DVKNKDAELATLKG----KLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
+K D E +LK K LE S K EL + + KK E AL +A+
Sbjct: 1208 KLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE---ALLEAKTN 1264
Query: 1457 EL 1458
EL
Sbjct: 1265 EL 1266
Score = 60.1 bits (139), Expect = 8e-08
Identities = 139/688 (20%), Positives = 286/688 (41%), Gaps = 52/688 (7%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+ + ++Q E L E L+K+ E E L++ A + SS LQ+
Sbjct: 556 ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAET-YRTRILELESSLEKSLQEN 614
Query: 326 VNE---LTTHNEDLRDE-KKHLTQKIREIESELETRPSTEAQ--TRQIEQLRAKLLAA-E 378
N+ L H E +++ K +T + + ++ELE+ + T +++ L+ + E
Sbjct: 615 KNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEME 674
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQAD----EYSSLRRELEQTIKNCRVL 434
L E+ E E + K+ + + ++ D E SL EL + +K L
Sbjct: 675 KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKL 734
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+L + + D+++QE E K+ E Q ++ IKE E + R TE AL+ Q
Sbjct: 735 EEELSVLKDQTDKMKQEL---EAKMDEQKNHHQ-QQVDSIIKEHEVSIQR-TEKALKDQI 789
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
E K + +K Q V+ + + R + A D+ S + E
Sbjct: 790 NQLELLLKERDKH---LKEHQAH-VENLEADIKRSEGELQQASAKLDVFQSYQSAT--HE 843
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE 614
Q + EE+ A +Q ++ ++T + + + + T +K I E
Sbjct: 844 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK-IQVQDLMQQLE 902
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK---KM 671
K +S K TQ Y S N ++ ++ + E+++LQ++ K
Sbjct: 903 KQNSE--MEQKVKSLTQV-----YESKLED--GNKEQEQTKQILVEKENMILQMREGQKK 953
Query: 672 ATKARSRKLSPTPPANKL---SIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
+ ++KLS + + ET N EK+ ++ ++ L ++ +
Sbjct: 954 EIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLK 1013
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
+ELE L ++ K+ +K+ + + ++ + A L TN + E +V E+++
Sbjct: 1014 KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELND 1073
Query: 789 V----RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
V KKL ++ + + +H E+ L +K+ + + + + ++ +++ +++E
Sbjct: 1074 VISIWEKKLNQQAEELQEIH-EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1132
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD-KALDLNTKKTTQLENELKEALAK 903
++ T E + Q L ++ L++ + L+++ K+ + L+E L
Sbjct: 1133 --VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLV- 1189
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETD 931
EL+M+ +++K +KV + K TD
Sbjct: 1190 --ELKMLAEEDK--RKVSELTSKLKTTD 1213
Score = 51.6 bits (118), Expect = 3e-05
Identities = 63/379 (16%), Positives = 160/379 (42%), Gaps = 16/379 (4%)
Query: 1434 KQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKE 1493
K++ + ++++E SL+ + +Y EL Y++L+ E + L+ ++++ + +++E
Sbjct: 167 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 226
Query: 1494 LSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD-QR 1552
L K LQE+ + + +Q ++ L++RL G V+ + +L+ Q
Sbjct: 227 LQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQA 286
Query: 1553 E---RELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXX 1609
E +E +D V+E E + K +
Sbjct: 287 EVFTKEENPESDGEPVVE--DGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLT 344
Query: 1610 XXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRER-----DNYKQM 1664
+++ R E+ K + + + +L+ N + + +++ + +QM
Sbjct: 345 SEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQM 404
Query: 1665 ---LEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLL 1721
LE ++ +A++++ K + E+ R LE+ ++ + R L
Sbjct: 405 HETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKL 464
Query: 1722 ASKLNTELVS-EKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDE 1780
++++ ++ + EK+S E R++ +Q L+ ++E + ++ +A +L + +
Sbjct: 465 KAEMDEQIKTIEKTSEEERIS-LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARK 523
Query: 1781 QQRLLQETSTLARDLRQTL 1799
+Q L ++ T R+ ++ +
Sbjct: 524 EQELTKKLQTREREFQEQM 542
Score = 42.3 bits (95), Expect = 0.017
Identities = 41/182 (22%), Positives = 87/182 (47%), Gaps = 17/182 (9%)
Query: 1615 IEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAE 1674
IEQ E+ + I +TK + + +E+ L +++ + + + ++ E +++ A
Sbjct: 386 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER--AA 443
Query: 1675 IKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLL----ASKLNTELV 1730
+ +K+ S + EE R A +++Q+ +E E R+ S++ E+V
Sbjct: 444 FEELEKAL-----STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV 498
Query: 1731 S-EKSSAEVRLAEMQSRLNEYE----EERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
K S+E ++A++Q +L+E E E+ L + R +M++A K + E ++
Sbjct: 499 DVMKKSSEEQIAKLQ-KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 557
Query: 1786 QE 1787
QE
Sbjct: 558 QE 559
>AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein.
Length = 1416
Score = 85.4 bits (202), Expect = 2e-15
Identities = 176/885 (19%), Positives = 377/885 (42%), Gaps = 89/885 (10%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E LK+E++ +R CE ++++ +L N + A+K ++ L+ ++ +
Sbjct: 440 EILKKELEAMRTFCESAKQDRL-----KLQN-ELAHKVAECKAL-ALECERVKEDSDEQI 492
Query: 334 EDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE-TLCEELMDENEDMK 392
+ L D K + +++ E E +++ + + E L ++ + L EEL D+ +D+K
Sbjct: 493 KQLEDALKDVQKRMYESEGKVKQMQTHFLALK--EHLTSEAASGNHRLTEELKDQLKDLK 550
Query: 393 KELRDLXXXXXXMQDNFREDQ--ADEYS----SLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ +++ ++++ +E+ L E ++ K + + +K RK
Sbjct: 551 VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVT 610
Query: 447 QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGS 506
++E + E KL + + EN L EV + + ++RE ++ S+
Sbjct: 611 EMEGQAKELSAKLALSIPAE---KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQL 667
Query: 507 NPSL--MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETA 564
L +K + VK + ++ +L + + + + L++++ +
Sbjct: 668 KRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNK 727
Query: 565 NCK-QVNPPTFLDKQVMTDNIVTCDIHES-ETVTNSIQNKMIHAASTPSSKEKS------ 616
K Q + T K V+ D+ +S + + + + K++ + K+
Sbjct: 728 LLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLL 787
Query: 617 DSPPLSIDKTTEETQF----HFDLPYLSIFNHMAA--NNLRKTAARVEEDNESL--LLQL 668
++ LS D + ET F + +++ +++ L + + ED E + L
Sbjct: 788 ENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSE 847
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
K S + P ++ + T ND K E ++K E QE ++ K
Sbjct: 848 NTNLKKMMSNQYVPVKTHEEVKM-TLNDTLAKTNREL--LDVKKKFEDINQEFVKIKDKN 904
Query: 729 EELEQDKEALKKQVK-ELTSKISSVTKTSAGSNTTARRSLTTNSNKLA-----EERVKVL 782
E L+++ E + Q+K E S K S+ S + R+ +N+ LA +E + L
Sbjct: 905 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM-RKVQDSNAEILANYRKGQEEIVTL 963
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQ 842
EI + +KK ++ ++C ++ ++ ++ + R A++++ LK QL Q
Sbjct: 964 HAEI-KAQKKELDTIQECIKVKYAPIVSFEECE-----RKFKATEKE---LKDQLSEQTQ 1014
Query: 843 EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN---TKKTTQLENELKE 899
+ SV + + + +N+KL+ E LQ K++ +K+ ++ ++KT +L +LK+
Sbjct: 1015 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD 1074
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
K E++ + K + E K+T + + Q
Sbjct: 1075 LSQKYTEVKNV--------KEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1126
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS-GKEMT 1018
T+++LK++ KS + R +K TKL +++E+ KN+ + + +
Sbjct: 1127 TIENLKEEL-KSMQ-RCYEKEQQTVTKLH--QLLEN-----------QKNSSVPLAEHLQ 1171
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
K EKE+ I++ L + + E N E ++LQ+E+ K KLE + V +KYKA
Sbjct: 1172 IKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKA 1231
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+ S+L Q +L E++ N + ++ ++ +A + + D
Sbjct: 1232 TK---SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1273
Score = 63.7 bits (148), Expect = 6e-09
Identities = 188/1031 (18%), Positives = 403/1031 (39%), Gaps = 89/1031 (8%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISS--VTKTSAGSNTTARRSLTTNSNKLA 775
E E L+ ++ +++Q++ L +V L +++ + S +SL K
Sbjct: 300 EIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQH 359
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
EE ++ +E ++ + K + + L + + +K L+K + +D Q
Sbjct: 360 EESLRTIE----ALKNRF--KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS--P 411
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT-QLE 894
+ Q S+LR SL + QT + ++LK K L + + + K+ +L+
Sbjct: 412 GIPAHMQSRSMLRPLELSLPS-----QTSYSENEILK--KELEAMRTFCESAKQDRLKLQ 464
Query: 895 NELKEALAKIKELEMICQ--DEKSEKKVRFTEATKKETDTL------KSKQXXXXXXXXX 946
NEL +A+ K L + C+ E S+++++ E K+ K KQ
Sbjct: 465 NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK 524
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL-TTKLQLKK---MVEDLECEIGE 1002
+ LKD K K + ++ + Q+K+ +VE+ + + G+
Sbjct: 525 EHLTSEAASGNHRLTEELKDQL-KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGK 583
Query: 1003 MYV----VMKNAGLSGKEMTAK----TKLEKEIDEIRSKLSKN--DSEFTNEKNRLQTEI 1052
+ + K + E K T++E + E+ +KL+ + +F N K+ L E+
Sbjct: 584 LIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEV 643
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
+ ++E + + ++ + L+ E N+ + L + +K E + K + K+
Sbjct: 644 NEKAKKLVEMEREHEKSLSEIRQLKRELENVKAK---LAQHVKPEEHEQVKSRLEQKSG- 699
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGD 1172
L +++ Q N T I+ + + +V + KK D
Sbjct: 700 ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLT-IEMKNHYVPLKVSEDMKKSHD 758
Query: 1173 XXXXXXXXXX---XCKRIEKQLSTRKDRVTXXXXXXXXXXXQAV-VLANTHRRLSIELTS 1228
K EK+L K + + V V H + I L S
Sbjct: 759 AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
EL+ + + + K + ++ L + EN T+L+ ++ + V +K E+ ++ T N
Sbjct: 819 NIVELKKQLSELKKKCGEDQEKIHALTS--EN--TNLKKMMSNQYVPVKTHEE-VKMTLN 873
Query: 1289 DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
D A + E+++++ +D+ K LE T+ + A + +A+ ++
Sbjct: 874 DTL--AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAK 931
Query: 1349 LAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAE 1408
++ L + + L ++++++K+LD ++ + +K K A
Sbjct: 932 MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ----ECIKVKYAP 987
Query: 1409 LATLKGKLKILEQNSGAGAKRITELKQEY---EETVKKLEHSLALEKAEY----EELTGK 1461
+ + + + + +++E Q+Y EE VKK + K E ++L K
Sbjct: 988 IVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDK 1047
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
L+E+ H + +A L+ + ++ +L K+LS E+K ++EKL E+A +E
Sbjct: 1048 TVLIEKSHEMERA-LSRKTDELNKQL----KDLSQKYTEVKNVKEKLVEENAKQTSEILA 1102
Query: 1522 MQN----------SIASLQERLCGGGWEVERARLNARLDQR--ERELRAANDRRDVLEHH 1569
+QN + +L++ L G +E + + QR E+E + +LE+
Sbjct: 1103 VQNLLQKQHVPLEQVEALKKSLNG---TIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ 1159
Query: 1570 HDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDT 1629
+ +E+ I + ++ + K +
Sbjct: 1160 KNSSVPLAEHLQIKEA-FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1218
Query: 1630 KTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSI 1689
+TR ++ + L Q+S + N + E + + K + SA+ + +
Sbjct: 1219 ETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL 1278
Query: 1690 SSTDEEEYRNK 1700
+ E+E +++
Sbjct: 1279 HFSIEQEIKDQ 1289
Score = 56.4 bits (130), Expect = 1e-06
Identities = 171/969 (17%), Positives = 357/969 (36%), Gaps = 68/969 (7%)
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEAD-NEK------LQTENKKLQLLKNAKSLRSDK 881
+N DLK +L+ I+QE +L K L+ NE+ L++E +KL+ L AK + ++
Sbjct: 302 ENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEE 361
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
+L + + + L +D ++ + ++ + + +
Sbjct: 362 SLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ + + +A ++F + L +L K V + +
Sbjct: 422 MLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHK--VAECKALAL 479
Query: 1002 EMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VN 1059
E V +++ K++ K ++K + E K+ + + F K L +E A +
Sbjct: 480 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 539
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKT---LTEEMKNREAQINKLSADLKNATSLQT 1116
+L+ KY+ E L NQ K + EE K E ++ + + L+ S+
Sbjct: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + K + K+ L EV +K KK+ +
Sbjct: 600 MEREKKGRKVTEMEGQAKELSAKLALSIPAE---KFENMKSSLSNEVNEKAKKLVEMERE 656
Query: 1177 XXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR--RLSIELTSEKDELQ 1234
++++++L K ++ ++ + + + ELT + LQ
Sbjct: 657 HEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQ 716
Query: 1235 ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN--DKYD 1292
K L+ + +L + +N L+ + K H ++D R+ + KY
Sbjct: 717 KEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYT 776
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
E +E + + L + EK E E A K + +LK L++L
Sbjct: 777 EKKLEMEKLLLENDSLSKDVS------RLETVFVPPEKHEKEIIALKSNIVELKKQLSEL 830
Query: 1353 ENX---------XXXXXXXXXXXXXXSSYWENKA-KELDTDLQSERKKLDRMRIAHDKDV 1402
+ + Y K +E+ L K +R + K
Sbjct: 831 KKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 890
Query: 1403 KNKDAELATLKGKLKILEQNSGAGAKRITE---LKQEYEETVKKLEHSLALEKAEYEELT 1459
++ + E +K K +IL++N +I E+E + L S+ + E+
Sbjct: 891 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 950
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
Y +EE V A + +K+ EL +Q+ + I + +E E TEK
Sbjct: 951 ANYRKGQEEIVTLHAEIKAQKK----ELDTIQECIKVKYAPIVSFEE---CERKFKATEK 1003
Query: 1520 TEMQNSIASLQERLCGGGWEVERARL-NARLDQRERELRA-ANDRRDVLEHHHDXXXXXX 1577
E+++ ++ ++ EV++ + N +L + L+ D+ ++E H+
Sbjct: 1004 -ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1062
Query: 1578 XXXXXXXXDYERVS------KIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
+ +S K + + Q + ++ K
Sbjct: 1063 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKK 1122
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKS---MAE---IKNG-DKSARI 1684
G + +++ELKS+ + ++ Q+LE + S +AE IK +K I
Sbjct: 1123 SLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1182
Query: 1685 HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
+ S+ EEE +NK+ ++V+ L+ E+ ++ KL T V + S + ++++
Sbjct: 1183 IKASLRE-KEEESQNKM----EEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
Query: 1745 SRLNEYEEE 1753
++++ E+
Sbjct: 1238 TQISSLNEK 1246
>AB209115-1|BAD92352.1| 1065|Homo sapiens restin isoform a variant
protein.
Length = 1065
Score = 84.6 bits (200), Expect = 3e-15
Identities = 152/675 (22%), Positives = 285/675 (42%), Gaps = 70/675 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+K E L +E + L+ + E KE SD++ + ++TA + ++ E LK+
Sbjct: 328 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA-SHQQAMEELKVSFS 386
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE-----AQTRQIEQLRAKLLAAETL 380
L T + + K + + + + E+E + + A +++E LRAKL+
Sbjct: 387 -KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 445
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEY--SSLRRELEQTIKNCRVLSFKL 438
E ++ + D M+D + Q E E+ + R + +
Sbjct: 446 KENSLEAIRSKLDKAED--QHLVEMEDTLNKLQEAEIKKEKFAEASEEAVSVQRSMQETV 503
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
K +K +Q ++ E KL E + + RE E E+++ ++ E +L+ ++AE
Sbjct: 504 NKLHQKEEQFNMLSSDLE-KLRENLADMEAKFREK--DEREEQLIKAKE---KLENDIAE 557
Query: 499 ANSKFTGSNPS-LMKVPQPETVK---VSRSSLTRGGSQEDPAQLLRDLQD-SLEREADLR 553
K +G N S L K+ +K V L + E+ + L + ++D +++ E +
Sbjct: 558 I-MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 616
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN-KMIHAASTPSS 612
E + EEE ++ + L+K++ ET N Q K + +T +
Sbjct: 617 EAAKKHEEEKKELER--KLSDLEKKM-------------ETSHNQCQELKARYERATSET 661
Query: 613 KEKSDSPPLSIDKTTEETQFHF------DLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
K K + ++ KT +T+ + L + + AA+ ED ++
Sbjct: 662 KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIME 721
Query: 667 QLKKMATKARSRKLSPTPPAN-KL--SIETANDNDEKETDEADPAEMKLLLELNEQEATV 723
Q+ K T+ + L T N KL ++T +N+ K +E + + K LL + Q+
Sbjct: 722 QMTKEKTETLA-SLEDTKQTNAKLQNELDTLKENNLKNVEELN--KSKELLTVENQKMEE 778
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
R+++E L+Q +Q+ L + + + S R T+ KL EER VL
Sbjct: 779 FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRS-----RDEVTSHQKLEEER-SVLN 832
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+++ E++K+ + +D + A L QK I S L D + L+ ++ V+ E
Sbjct: 833 NQLLEMKKRESKFIKDADEEKASL---QK--SISITSALLTEKDAELEKLRNEVTVLRGE 887
Query: 844 ---ASVLRAKTQSLEADNEKLQ--TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
A L + Q+LE+D KL+ +N +LQL +N + L S NT + +
Sbjct: 888 NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG---NTDTQADEDERAQ 944
Query: 899 EALAKIKELEMICQD 913
E+ I L + D
Sbjct: 945 ESQQMIDFLNSVIVD 959
Score = 72.9 bits (171), Expect = 1e-11
Identities = 165/837 (19%), Positives = 341/837 (40%), Gaps = 63/837 (7%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
+K++ T E L+++++H+ Q + E + E R T + ++ +L A ++
Sbjct: 96 RKISGTTALQEALKEKQQHIEQLLAERDLE---RAEVAKATSHVGEIEQELALARDGHDQ 152
Query: 384 LMDENEDMKKELRDLXXXXXXMQD---NFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
+ E E +LR + + N E++ + L+ +E+ L + K
Sbjct: 153 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL 212
Query: 441 TERKADQLEQ----EKAEHEKKLLEIVGGPDG-MQRENRIKELEQEVARSTEVALRLQRE 495
+ +LEQ EK + +K E+ + ++RI ELE+++A + L+R
Sbjct: 213 EHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRR 272
Query: 496 LAEANSKFTGSNPSLMKVPQ----PETVKVSRSSLTR---------GGSQEDPAQLLRDL 542
L E+N + SL + + E ++V+R+ R G +E + ++ L
Sbjct: 273 L-ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKAL 331
Query: 543 QDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNK 602
+ E+ + E L+ ++ E AN K+ + L K + I + E + +
Sbjct: 332 YTATEKLSKENESLK-SKLEHAN-KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 389
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
A K + + L E Q D + M A LR +V ++ E
Sbjct: 390 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEA--LRAKLMKVIKEKE 447
Query: 663 SLLLQLKKMATKARSRKL-SPTPPANKL-SIETANDNDEKETDEADPAEMKLLLELN--- 717
+ L ++ KA + L NKL E + + ++EA + + +N
Sbjct: 448 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKKEKFAEASEEAVSVQRSMQETVNKLH 507
Query: 718 --EQEATVLRRKVEELEQ---DKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E++ +L +E+L + D EA ++ E ++ + + NS+
Sbjct: 508 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 567
Query: 773 KLAE--ERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
+L + + +++ E +++E++ KL + + L + K + + + +++
Sbjct: 568 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ-SQQEAAKKHEEEK 626
Query: 831 VDLKRQLQVIEQEASVLRAKTQSLEADNEKL--QTENKKLQLLKNAKS--LRSDKALDLN 886
+L+R+L +E++ + Q L+A E+ +T+ K ++L+N + L ++ L
Sbjct: 627 KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA 686
Query: 887 TKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS----KQXXXXX 942
++ + L EL+E L K E Q + ++ + TK++T+TL S KQ
Sbjct: 687 REENSGLLQELEE-LRKQAEKAKAAQTAEDAMQI-MEQMTKEKTETLASLEDTKQTNAKL 744
Query: 943 XXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGE 1002
+ KS + ++ K +K + T K + + L E
Sbjct: 745 QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIE-TLKQAAAQKSQQLSALQEE 803
Query: 1003 MYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKL---SKNDSEFTNEKNRLQTEIAKLKDVN 1059
+ + G S E+T+ KLE+E + ++L K +S+F + + + + K +
Sbjct: 804 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISIT 863
Query: 1060 AKLEGDKDV----FANKYKALENENS---NLSNQCKTLTEEMKNREAQINKLSADLK 1109
+ L +KD N+ L EN+ +L + +TL + E ++ L LK
Sbjct: 864 SALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 920
Score = 65.3 bits (152), Expect = 2e-09
Identities = 166/844 (19%), Positives = 330/844 (39%), Gaps = 73/844 (8%)
Query: 699 EKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
E+E A + +LEL E + LR VE +++K L Q++E K+ + +
Sbjct: 140 EQELALARDGHDQHVLEL-EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDL-QFRVE 197
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
+ + L T + KL R+K LE + L EK + A K + L
Sbjct: 198 EESITKGDLETQT-KLEHARIKELEQSL------LFEKTK-----------ADKLQRELE 239
Query: 819 KSRSLDASDQQNV-DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSL 877
+R S++ + +L++ L + QE + LR + +S N+ + L LL+ SL
Sbjct: 240 DTRVATVSEKSRIMELEKDLALRVQEVAELRRRLES----NKPAGDVDMSLSLLQEISSL 295
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK- 936
+ + L++ + LKE +E ++ + TE KE ++LKSK
Sbjct: 296 Q--EKLEVTRTDHQREITSLKEHFGAREETHQ----KEIKALYTATEKLSKENESLKSKL 349
Query: 937 QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT-KLQLKKMVED 995
+ A+ + ++ + SF + + + K Q++KM D
Sbjct: 350 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 409
Query: 996 LECEIGEMYVVMKNAGLS-GKEMTA-KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIA 1053
+ EI + + + KEM A + KL K I E + L S+ +++ +
Sbjct: 410 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ---HLV 466
Query: 1054 KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+++D KL+ + ++ K+ E ++ + ++ +E Q N LS+DL+
Sbjct: 467 EMEDTLNKLQ-EAEIKKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK--- 522
Query: 1114 LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDX 1173
L+ ++D + K++ D +++K GD + ++
Sbjct: 523 LRENLADMEAKFREKDEREEQL----------IKAKEKLENDIAEIMKMSGDNSSQLTKM 572
Query: 1174 XXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL 1233
+ ++ +L+ + + +A + + + + EK EL
Sbjct: 573 NDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA---EQSQQEAAKKHEEEKKEL 629
Query: 1234 QARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDE 1293
+ + E K T + ++LKA YE + TS E+ +++ ++ L+ L T DK
Sbjct: 630 ERKLSDLEKKMETSHNQCQELKARYE-RATS-ETKTKHEEI-LQNLQKTLLD-TEDKLKG 685
Query: 1294 ATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLE 1353
A + +A +E+ E + + K AKL+
Sbjct: 686 AREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 745
Query: 1354 NXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD-VKNKDAELATL 1412
N NK+KEL T +++++ + R I K K +L+ L
Sbjct: 746 NELDTLKENNLKNVEEL----NKSKELLT-VENQKMEEFRKEIETLKQAAAQKSQQLSAL 800
Query: 1413 KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYE---LLEEEH 1469
+ + L + G +T ++ EE L ++K E + + E L++
Sbjct: 801 QEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSI 860
Query: 1470 VVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASL 1529
+T A LT EK+ EL ++ E++ GE + L + ++K +++ + +L
Sbjct: 861 SITSALLT-EKD---AELEKLRNEVTVLRGE-NASAKSLHSVVQTLESDKVKLELKVKNL 915
Query: 1530 QERL 1533
+ +L
Sbjct: 916 ELQL 919
Score = 63.7 bits (148), Expect = 6e-09
Identities = 159/827 (19%), Positives = 315/827 (38%), Gaps = 50/827 (6%)
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
T + K + + +K S S + +S S+ ++R S T + + +
Sbjct: 38 TPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARK 97
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ---LQ 838
+ +++ L EK++ E+L AE L + + + K+ S +Q + L R
Sbjct: 98 ISGTT-ALQEALKEKQQHIEQLLAERDLERAE---VAKATSHVGEIEQELALARDGHDQH 153
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
V+E EA + + +T AD EK++ N+ + + + L+ + TK + + +L+
Sbjct: 154 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLE 213
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
A K E ++ + K++K R E T+ T + KS+ +
Sbjct: 214 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSR---IMELEKDLALRVQEVAELR 270
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE-CEIGEMYVVMKNAGLSGKE- 1016
L+S K + ++ + L KL++ + E + E + + +
Sbjct: 271 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKA 330
Query: 1017 -MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
TA KL KE + ++SKL E N++N IA K +KLE A+ +A
Sbjct: 331 LYTATEKLSKENESLKSKL-----EHANKEN--SDVIALWK---SKLE---TAIASHQQA 377
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKN-ATSLQTTM-SDCMXXXXXXXXXXX 1133
+E + S T T E + QI K+ D ++ +LQ S+
Sbjct: 378 MEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRA 437
Query: 1134 XXXXXXXXXXXQVDNY-TKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLS 1192
++ +K+D+ +++ L E+ D K+ + +
Sbjct: 438 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKKEKFAEASEEAVSVQR 497
Query: 1193 TRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-IELT-SEKDELQARFIKTESKFITLEAE 1250
+ ++ V + L L+ +E EKDE + + IK + K AE
Sbjct: 498 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 557
Query: 1251 MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
+ + D +++T + + K+ +++L+ L + N+ +E + ++
Sbjct: 558 IMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK-ANENASFLQKSIEDMTVKAEQSQQ 616
Query: 1311 XXXXXXXQD------ELNNAKIKLEKTEAESSAAKLEMAQLKSDL-AKLENXXXXXXXXX 1363
++ +L++ + K+E + + K + S+ K E
Sbjct: 617 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 676
Query: 1364 XXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLK--GKLKILEQ 1421
+ L +L+ RK+ ++ + A + + E T + L LE
Sbjct: 677 LDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLED 736
Query: 1422 NSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE--EHVVTKARLTVE 1479
AK EL E +K +E L K++ E LT + + +EE + + T + +
Sbjct: 737 TKQTNAKLQNELDTLKENNLKNVEE---LNKSK-ELLTVENQKMEEFRKEIETLKQAAAQ 792
Query: 1480 KEQAQGELLHVQKELSTALGEIK---TLQEKLGTESAAWNTEKTEMQ 1523
K Q L +L+ LG + T +KL E + N + EM+
Sbjct: 793 KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMK 839
Score = 60.1 bits (139), Expect = 8e-08
Identities = 101/525 (19%), Positives = 206/525 (39%), Gaps = 40/525 (7%)
Query: 1247 LEAEMRDLKADYENKITSLESTI-AAKDVHIKQLEDALR-----QTTNDKYDEATSPVEM 1300
L A++ + + EN + ++ S + A+D H+ ++ED L + +K+ EA+ E
Sbjct: 435 LRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKKEKFAEASE--EA 492
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE---AESSAAKLEMAQLKSDLAKLENXXX 1357
V ++ +++ N LEK A+ A E + + L K +
Sbjct: 493 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLE 552
Query: 1358 XXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLK 1417
+S ++ +++ +L+ + + ++ +++ K +N +++
Sbjct: 553 NDIAEIMKMSGDNS---SQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 609
Query: 1418 ILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLT 1477
EQ+ AK+ E K+E E + LE + + +EL +YE E TK +
Sbjct: 610 KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSE---TKTKHE 666
Query: 1478 VEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGG 1537
+ Q LL + +L A E L ++L E EK + + + +
Sbjct: 667 EILQNLQKTLLDTEDKLKGAREENSGLLQEL--EELRKQAEKAKAAQTAEDAMQIM--EQ 722
Query: 1538 WEVERARLNARL-DQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRX 1596
E+ A L D ++ + N+ + E++ + +++ + ++
Sbjct: 723 MTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE 782
Query: 1597 XXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRR 1656
Q E + AE ++ RDE+ S H ++ R
Sbjct: 783 IETLKQAAAQKSQQLSAL--QEENVKLAE----------ELGRSRDEVTS-HQKLEEERS 829
Query: 1657 ERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDE--EEYRNKVALLEQQVACLEDE 1714
+N Q+LE ++ IK+ D+ + SIS T E ++ L +V L E
Sbjct: 830 VLNN--QLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE 887
Query: 1715 LCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSG 1759
++ L S + T L S+K E+++ ++ +L E + + SSG
Sbjct: 888 NASAKSLHSVVQT-LESDKVKLELKVKNLELQLKENKRQLSSSSG 931
Score = 56.4 bits (130), Expect = 1e-06
Identities = 94/491 (19%), Positives = 202/491 (41%), Gaps = 45/491 (9%)
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
Q+ L + +E+ AE + E+A+ S + ++E E K
Sbjct: 105 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLEL---EAKM 161
Query: 1378 KELDTDLQS-ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQE 1436
+L T +++ +R+K++ + ++ K +D + +E+ S T+ K E
Sbjct: 162 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFR--------VEEESITKGDLETQTKLE 213
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELST 1496
+ +K+LE SL EK + ++L + LE+ V T + EK + ++ ++K+L+
Sbjct: 214 HAR-IKELEQSLLFEKTKADKLQRE---LEDTRVATVS----EKSR----IMELEKDLAL 261
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKT-EMQNSIASLQERLCGGGWEVERA------RLNARL 1549
+ E+ L+ +L + A + + + + I+SLQE+L + +R AR
Sbjct: 262 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 321
Query: 1550 DQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXX 1609
+ ++E++A + L ++ D + K +
Sbjct: 322 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK--LETAIASHQQAME 379
Query: 1610 XXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQ 1669
+ AE + KT+ E + E+++L NQ R + K+M
Sbjct: 380 ELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAA--HAKEMEALRA 437
Query: 1670 KSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
K M IK + S R+ + +++ L+E + ++L E+ + K E
Sbjct: 438 KLMKVIKEKENSLEAIRSKLDKAEDQH------LVEMEDTL--NKLQEAEIKKEKF-AEA 488
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKERDEQQRLLQET 1788
E S + + E ++L++ EE+ +LSS ++ ME + ++ + +++L++
Sbjct: 489 SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 548
Query: 1789 STLARDLRQTL 1799
L D+ + +
Sbjct: 549 EKLENDIAEIM 559
Score = 45.2 bits (102), Expect = 0.002
Identities = 88/379 (23%), Positives = 159/379 (41%), Gaps = 37/379 (9%)
Query: 134 KRRLTGPLPDLDTGQTTNGSQTQLAITK-NDSLAERVRKMQ--LLKTQNSFEKEPSIEKE 190
K +L + ++ N SQ +TK ND L + R ++ LK + E ++K
Sbjct: 548 KEKLENDIAEIMKMSGDNSSQ----LTKMNDELRLKERDVEELQLKLTKANENASFLQKS 603
Query: 191 RERRSLSKSKEDEKTAR-YKDERSSTKDDVNFL-MQVKNSRNSTN-LKPPVRGGPXXXXX 247
E ++ + ++ A+ +++E+ + ++ L +++ S N LK
Sbjct: 604 IEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 663
Query: 248 XXXXXXXXXXXXXL-VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANID 306
L + +K +++ GL QE++ LRK+ E+ + ++ ++
Sbjct: 664 KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQM 723
Query: 307 TANKYTTGRSSE-----VLKLQQKVNELTTHN----EDLRDEKKHLT---QKIREIESEL 354
T K T S E KLQ +++ L +N E+L K+ LT QK+ E E+
Sbjct: 724 TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI 783
Query: 355 ETRPSTEAQTRQIEQLRAKLLAAETLCEEL---MDE---NEDMKKELRDLXXXXXXM--- 405
ET AQ Q QL A L EEL DE ++ +++E L M
Sbjct: 784 ETLKQAAAQKSQ--QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 841
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG- 464
+ F +D +E +SL++ + T +L+K + L E A K L +V
Sbjct: 842 ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS-AKSLHSVVQT 900
Query: 465 -GPDGMQRENRIKELEQEV 482
D ++ E ++K LE ++
Sbjct: 901 LESDKVKLELKVKNLELQL 919
Score = 37.9 bits (84), Expect = 0.37
Identities = 49/272 (18%), Positives = 102/272 (37%), Gaps = 32/272 (11%)
Query: 1425 AGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ 1484
+G + E +E ++ +++L LE+AE + T +E+E + +
Sbjct: 99 SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALAR----------D 148
Query: 1485 GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-----ERLCGGGWE 1539
G HV EL + +++T+ E E + E + + LQ E + G E
Sbjct: 149 GHDQHV-LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE 207
Query: 1540 VERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYER--------VS 1591
+ +AR+ + E+ L + D L+ + + E+ V+
Sbjct: 208 TQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVA 267
Query: 1592 KIQRXXXX--------XXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDE 1643
+++R +E + + EIT K + + T + E
Sbjct: 268 ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 327
Query: 1644 LKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI 1675
+K+L+ + +E ++ K LE A K +++
Sbjct: 328 IKALYTATEKLSKENESLKSKLEHANKENSDV 359
>X64838-1|CAA46050.1| 1427|Homo sapiens restin protein.
Length = 1427
Score = 84.2 bits (199), Expect = 4e-15
Identities = 167/871 (19%), Positives = 356/871 (40%), Gaps = 80/871 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+K E L +E + L+ + E KE SD++ + ++TA + ++ E LK+
Sbjct: 577 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA-SHQQAMEELKVSFS 635
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
L T + + K + + + + E+E Q +Q + A E L +LM
Sbjct: 636 -KGLGTETAEFAELKTQIEKMRLDYQHEIE-----NLQNQQDSERAAHAKEMEALRAKLM 689
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
++ + L + +D + D + L +E E +K VL K + +
Sbjct: 690 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIKVKELEVLQAKCNEQTKVI 748
Query: 446 DQLEQEKAEHEKKLLEIVG-GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
D + E+KLL++ + ++ +K+L Q++ + + L+ E +SK +
Sbjct: 749 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 808
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD-LREQLRNAEEET 563
S+ + Q +K++ QE+ ++ + ++++LE+E L+E+ A EE
Sbjct: 809 ----SITRELQGRELKLT-------NLQENLSE-VSQVKETLEKELQILKEKFAEASEEA 856
Query: 564 ANCKQVNPPTF--LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
+ ++ T L ++ N+++ D+ + ++ K +EK +
Sbjct: 857 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF---------REKDEREEQ 907
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
I + ++ +S N + E D E L L+L K A
Sbjct: 908 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL--- 964
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
+ SIE E+ EA + +E+E L RK+ +LE+ E Q
Sbjct: 965 ------QKSIEDMTVKAEQSQQEA--------AKKHEEEKKELERKLSDLEKKMETSHNQ 1010
Query: 742 VKELTS---KISSVTKTSAGS-NTTARRSLTTNSNKL--AEERVKVLEDEIDEVRKKLIE 795
+EL + + +S TKT +++L +KL A E L E++E+RK+ +
Sbjct: 1011 CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ-AD 1069
Query: 796 KERDCERLHAELSLAQKKPKTLIKS-RSLDASDQQNVDLKRQLQVIEQ----EASVLRAK 850
K + + + + ++ K ++ SL+ + Q N L+ +L +++ L
Sbjct: 1070 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1129
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
+ L +N+K++ K+++ LK A + +S + L ++ +L EL + ++ + +
Sbjct: 1130 KELLTVENQKMEEFRKEIETLKQAAAQKSQQ-LSALQEENVKLAEELGRSRDEVTSHQKL 1188
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
++E+S + E K+E+ +K A L+ L+++
Sbjct: 1189 -EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNE--- 1244
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEI 1030
+ + + L +V+ LE + ++ + +KN L KE K +L
Sbjct: 1245 -----VTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKE--NKRQLSSSSGNT 1297
Query: 1031 RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTL 1090
++ +++ ++ + L + I L+ N L+ ++ + AL +L+N
Sbjct: 1298 DTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE--AALNGNGDDLNNYD--- 1352
Query: 1091 TEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
+++ + + + +L D+ + L T DC
Sbjct: 1353 SDDQEKQSKKKPRLFCDICDCFDLHDT-EDC 1382
Score = 81.8 bits (193), Expect = 2e-14
Identities = 209/1101 (18%), Positives = 407/1101 (36%), Gaps = 83/1101 (7%)
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
T + K + + +K S S + +S S+ ++R S T + + +
Sbjct: 287 TPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARK 346
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ---LQ 838
+ +++ L EK++ E+L AE L + + + K+ S +Q + L R
Sbjct: 347 ISGTT-ALQEALKEKQQHIEQLLAERDLERAE---VAKATSHVGEIEQELALARDGHDQH 402
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
V+E EA + + +T AD EK++ N+ + + + L+ + TK + + +L+
Sbjct: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLE 462
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
A K E ++ + K++K R E T+ T + KS+ +
Sbjct: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSR---IMELEKDLALRVQEVAELR 519
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC-EIGEMYVVMKNAGLSGKEM 1017
L+S K + ++ + L KL++ + E + E + + +
Sbjct: 520 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKA 579
Query: 1018 --TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
TA KL KE + ++SKL E N++N IA K +KLE A+ +A
Sbjct: 580 LYTATEKLSKENESLKSKL-----EHANKEN--SDVIALWK---SKLE---TAIASHQQA 626
Query: 1076 LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXX 1135
+E + S T T E + QI K+ D ++ D
Sbjct: 627 MEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD--SERAAHAKEMEAL 684
Query: 1136 XXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE--KQLST 1193
+ +N ++ ++KL K ++ D K +E +
Sbjct: 685 RAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCN 742
Query: 1194 RKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRD 1253
+ +V + ++ + R+ S E SE +L+ + E + LE E
Sbjct: 743 EQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE--- 799
Query: 1254 LKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXX 1313
K +K +S+ + +++ + L++ L + + K T E+ ++
Sbjct: 800 -KNAESSKASSITRELQGRELKLTNLQENLSEVSQVK---ETLEKELQILKEKFAEASEE 855
Query: 1314 XXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYW 1373
Q + KL + E + + ++ +L+ +LA +E
Sbjct: 856 AVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 915
Query: 1374 ENKAKEL---DTDLQSERKKL-DRMRIAHDKDVKNKDAELATLKGKLKIL---------- 1419
EN E+ D S+ K+ D +R+ ++DV+ +L L
Sbjct: 916 ENDIAEIMKMSGDNSSQLTKMNDELRLK-ERDVEELQLKLTKANENASFLQKSIEDMTVK 974
Query: 1420 -EQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
EQ+ AK+ E K+E E + LE + + +EL +YE E TK +
Sbjct: 975 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSE---TKTKHEE 1031
Query: 1479 EKEQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGG 1537
+ Q LL + +L A E LQE A + + + E++
Sbjct: 1032 ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMT--- 1088
Query: 1538 WEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXX 1597
+ + L + D ++ + N+ + E++ + +++ + ++
Sbjct: 1089 -KEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI 1147
Query: 1598 XXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRE 1657
Q E + AE ++ RDE+ S H ++ R
Sbjct: 1148 ETLKQAAAQKSQQLSAL--QEENVKLAE----------ELGRSRDEVTS-HQKLEEERSV 1194
Query: 1658 RDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDE--EEYRNKVALLEQQVACLEDEL 1715
+N Q+LE ++ IK+ D+ + SIS T E ++ L +V L E
Sbjct: 1195 LNN--QLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGEN 1252
Query: 1716 CESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWH 1775
++ L S + T L S+K E+++ ++ +L E +R LSS A E A
Sbjct: 1253 ASAKSLHSVVQT-LESDKVKLELKVKNLELQLK--ENKRQLSSSSGNTDTQADEDERAQE 1309
Query: 1776 KERDEQQRLLQETSTLARDLR 1796
+ D ++ + +DL+
Sbjct: 1310 SQIDFLNSVIVDLQRKNQDLK 1330
Score = 63.3 bits (147), Expect = 9e-09
Identities = 182/980 (18%), Positives = 376/980 (38%), Gaps = 103/980 (10%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
+K++ T E L+++++H+ Q + E + E R T + ++ +L A ++
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLE---RAEVAKATSHVGEIEQELALARDGHDQ 401
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSFKLKKTE 442
+ E E +LR + + AD E L +LE+ + L F++++
Sbjct: 402 HVLELEAKMDQLRTMV------------EAADREKVELLNQLEEEKRKVEDLQFRVEEES 449
Query: 443 -RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
K D Q K EH RIKELEQ + A +LQREL +
Sbjct: 450 ITKGDLETQTKLEHA-----------------RIKELEQSLLFEKTKADKLQRELEDTRV 492
Query: 502 KFTGSNPSLMKVPQPETVKVSR-SSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLRNA 559
+M++ + ++V + L R PA + D+ SL +E + L+E+L
Sbjct: 493 ATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDV-DMSLSLLQEISSLQEKL--- 548
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T Q + + + +I T T + + S K +S
Sbjct: 549 -EVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD 607
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRK 679
+++ K+ ET +I +H A K + E+ + ++ T+ +
Sbjct: 608 VIALWKSKLET---------AIASHQQAMEELKVSFSKGLGTET--AEFAELKTQIEKMR 656
Query: 680 LSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQ----D 734
L L + ++ + EA A++ +++ E +R K+++ E +
Sbjct: 657 LDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVE 716
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
E +++E K+ + A N + + +++L K+L ++D +RK
Sbjct: 717 MEDTLNKLQEAEIKVKELEVLQAKCNEQT-KVIDNFTSQLKATEEKLL--DLDALRKASS 773
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSL 854
E + + ++L +L A+K+ K L ++ ++S ++ R+LQ E + + L+ ++L
Sbjct: 774 EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSI--TRELQGRELKLTNLQ---ENL 828
Query: 855 EADNEKLQTENKKLQLLKNAKSLRSDKALDL--NTKKTTQLENELKEALAKI-KELEMIC 911
++ +T K+LQ+LK + S++A+ + + ++T ++ +E + +LE +
Sbjct: 829 SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL- 887
Query: 912 QDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
++ ++ + +F E ++E +K+K+ + L + D+
Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKE----KLENDIAEIMKMSGDNSSQLTKMNDEL--- 940
Query: 972 FKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIR 1031
R+ ++ + +LQLK + + + + A K E+E E+
Sbjct: 941 ---RLKERDVE---ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELE 994
Query: 1032 SKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE-GDKDVFANKYKALENENSNLSNQCKTL 1090
KLS + + N+ Q A+ + ++ + +++ N K L + L K
Sbjct: 995 RKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL----KGA 1050
Query: 1091 TEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT 1150
EE ++ +L A + QT
Sbjct: 1051 REENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQN 1110
Query: 1151 KIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXX 1210
++D K LK V +++ + K++ T K
Sbjct: 1111 ELDTLKENNLKNV----EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQE 1166
Query: 1211 QAVVLANTHRRLSIELTSEKDELQARFI---------KTESKFITLEAEMRDLKADYENK 1261
+ V LA R E+TS + + R + K ESKFI + + KA +
Sbjct: 1167 ENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI---KDADEEKASLQKS 1223
Query: 1262 ITSLESTIAAKDVHIKQLED 1281
I+ + + KD +++L +
Sbjct: 1224 ISITSALLTEKDAELEKLRN 1243
Score = 53.6 bits (123), Expect = 7e-06
Identities = 108/598 (18%), Positives = 233/598 (38%), Gaps = 42/598 (7%)
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITS--LESTIAAKDV-HIKQLEDALRQTTN 1288
E +R+ + S L+ +++ + E + LE AK H+ ++E L
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA-LAR 396
Query: 1289 DKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLK 1346
D +D+ +E M ++R ++L K K+E + + L+
Sbjct: 397 DGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE 456
Query: 1347 SDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL--DRMRIAH-DKDVK 1403
+ KLE+ + + KA +L +L+ R ++ RI +KD+
Sbjct: 457 TQ-TKLEHARIKELEQSLL------FEKTKADKLQRELEDTRVATVSEKSRIMELEKDLA 509
Query: 1404 NKDAELATLKGKLKILEQNSGAGAKRIT-ELKQEYEETVKKLEHSLALEKAEYEELTGKY 1462
+ E+A L+ +L E N AG ++ L QE +KLE + + E L +
Sbjct: 510 LRVQEVAELRRRL---ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF 566
Query: 1463 ELLEEEH-------VVTKARLTVEKEQAQGELLHVQKELSTALGEIKT-LQEKLGTESAA 1514
EE H +L+ E E + +L H KE S + K+ L+ + + A
Sbjct: 567 GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQA 626
Query: 1515 WNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD----QRERELRAANDRRDVLEHHH 1570
K + + ++E+ RL+ + + Q +++ A +++
Sbjct: 627 MEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRA 686
Query: 1571 DXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE--KARKAEITD 1628
++ K + +++ E +A+ E T
Sbjct: 687 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 746
Query: 1629 TKTRYEGQMNTMRD---ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH 1685
+ Q+ + +L +L S + E +Q LEAA+K + ++ +K+A
Sbjct: 747 VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI-EKNAESS 805
Query: 1686 RNSISSTDEEEYRNKVALLEQ---QVACLEDELCESRLLASKLNTELVSEKSSAEVRLAE 1742
+ S + + + K+ L++ +V+ +++ L + + + E E S + + E
Sbjct: 806 KASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 865
Query: 1743 MQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
++L++ EE+ +LSS ++ ME + ++ + +++L++ L D+ + +
Sbjct: 866 TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923
Score = 44.0 bits (99), Expect = 0.006
Identities = 87/379 (22%), Positives = 159/379 (41%), Gaps = 37/379 (9%)
Query: 134 KRRLTGPLPDLDTGQTTNGSQTQLAITK-NDSLAERVRKMQ--LLKTQNSFEKEPSIEKE 190
K +L + ++ N SQ +TK ND L + R ++ LK + E ++K
Sbjct: 912 KEKLENDIAEIMKMSGDNSSQ----LTKMNDELRLKERDVEELQLKLTKANENASFLQKS 967
Query: 191 RERRSLSKSKEDEKTAR-YKDERSSTKDDVNFL-MQVKNSRNSTN-LKPPVRGGPXXXXX 247
E ++ + ++ A+ +++E+ + ++ L +++ S N LK
Sbjct: 968 IEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 1027
Query: 248 XXXXXXXXXXXXXL-VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANID 306
L + +K +++ GL QE++ LRK+ ++ + ++ ++
Sbjct: 1028 KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQM 1087
Query: 307 TANKYTTGRSSE-----VLKLQQKVNELTTHN----EDLRDEKKHLT---QKIREIESEL 354
T K T S E KLQ +++ L +N E+L K+ LT QK+ E E+
Sbjct: 1088 TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI 1147
Query: 355 ETRPSTEAQTRQIEQLRAKLLAAETLCEEL---MDE---NEDMKKELRDLXXXXXXM--- 405
ET AQ Q QL A L EEL DE ++ +++E L M
Sbjct: 1148 ETLKQAAAQKSQ--QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1205
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG- 464
+ F +D +E +SL++ + T +L+K + L E A K L +V
Sbjct: 1206 ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS-AKSLHSVVQT 1264
Query: 465 -GPDGMQRENRIKELEQEV 482
D ++ E ++K LE ++
Sbjct: 1265 LESDKVKLELKVKNLELQL 1283
Score = 41.5 bits (93), Expect = 0.030
Identities = 105/615 (17%), Positives = 249/615 (40%), Gaps = 60/615 (9%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E+ + + +Q +E ++ + R++ S+ K + K R + E + + + L K
Sbjct: 743 EQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE--AAEKQIKHLEIEK 800
Query: 227 NSRNS--TNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQI-EGLKQEVDIL 283
N+ +S +++ ++G ++ ++ +++ E ++ V +
Sbjct: 801 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 860
Query: 284 RKRCERVEK--EKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKK 341
R E V K +K + ++++ + ++ + ++ +L E L ++
Sbjct: 861 RSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA 920
Query: 342 HLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXX 400
+ + + S+L + + R +E+L+ KL A L EDM +
Sbjct: 921 EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 980
Query: 401 XXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEH-EKKL 459
+ +++ + S L +++E + C+ L + ++ + +E ++ +K L
Sbjct: 981 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040
Query: 460 LEIVGGPDGMQRENR--IKELEQ--------EVARSTEVALRLQRELA------------ 497
L+ G + EN ++ELE+ + A++ E A+++ ++
Sbjct: 1041 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1100
Query: 498 --EANSKFTGSNPSLMK--VPQPETVKVSRSSLT-RGGSQEDPAQLLRDL-----QDSLE 547
+ N+K +L + + E + S+ LT E+ + + L Q S +
Sbjct: 1101 TKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1160
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQ--VMTDNIVTCDIHESETVTNSIQNKMIH 605
A E ++ AEE + +V L+++ V+ + ++ ES+ + ++ + K
Sbjct: 1161 LSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK--- 1217
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
AS K S + L +K E + ++ L N +A +L +E D L
Sbjct: 1218 -ASL--QKSISITSALLTEKDAELEKLRNEVTVLRGEN-ASAKSLHSVVQTLESDKVKLE 1273
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
L++K + + + NK + +++ N + + DE + A+ + LN L+
Sbjct: 1274 LKVKNLELQLKE---------NKRQLSSSSGNTDTQADEDERAQESQIDFLN-SVIVDLQ 1323
Query: 726 RKVEELEQDKEALKK 740
RK ++L+ E + +
Sbjct: 1324 RKNQDLKMKVEMMSE 1338
>AB111886-1|BAC98374.1| 1571|Homo sapiens KIAA2034 protein protein.
Length = 1571
Score = 84.2 bits (199), Expect = 4e-15
Identities = 172/869 (19%), Positives = 358/869 (41%), Gaps = 76/869 (8%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDIL--LRRLANIDTANKYTTGRSSE----- 318
V+E Q Q +EV L+ R ++E+E++ + LR A + + T GR +
Sbjct: 457 VQELQQQSA---REVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQEL 513
Query: 319 ---VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQL--RAK 373
V +L+ +V E + ++ EKK L Q I+E+E+ LE Q Q+E++ AK
Sbjct: 514 ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR-QKLQLEKVTTEAK 572
Query: 374 LLAAETLCEELMDENEDMKKE--LRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC 431
+ E L D+N + KE L + Q E++ + LR + E TI +
Sbjct: 573 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD- 631
Query: 432 RVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
+ +L+K E+ +LE+ K + + E+ ++++ R +EL ++ R E
Sbjct: 632 --MEDRLRKEEKGRQELEKLKRRLDGESSEL--QEQMVEQQQRAEELRAQLGRKEE---E 684
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-A 550
LQ LA A + G+ L+K +++ ++++L + ++ R + R+
Sbjct: 685 LQAALARAEDE-GGARAQLLK-----SLREAQAALAEAQEDLESERVARTKAEKQRRDLG 738
Query: 551 DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN-KMIHAAST 609
+ E LR E+T + ++ + E+ ++Q + H +
Sbjct: 739 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 798
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
E+ + E+T+ + + ++L+ E+ L LQL+
Sbjct: 799 GELAEQLEQARRG-KGAWEKTRLALEAEVSEL--RAELSSLQTARQEGEQRRRRLELQLQ 855
Query: 670 KMATKARSRKLSPTPPANKLSIETAN-DNDEKETDEADPAEMKLLLELNEQEATV--LRR 726
++ +A + + A KL A +N +EA+ ++L EL+ EA + +
Sbjct: 856 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 915
Query: 727 KVEELEQDKEALKKQVKELTSKISSV---TKTSAGSNTTARRSLTTNSNKLA------EE 777
++E + K AL +V+ + ++ + + + A + A R L T +L+ EE
Sbjct: 916 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE 975
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
LE + R+ E E +RL + + + + R D +DL++Q
Sbjct: 976 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG--RRRLQQELDDATMDLEQQR 1033
Query: 838 QVIEQ--------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
Q++ + + K L A E+ + E + + + A++L +AL+ +
Sbjct: 1034 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRE--REARALSLTRALEEEQEA 1091
Query: 890 TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXX 949
+LE + + A+++ L + +D+ + A + +
Sbjct: 1092 REELERQNRALRAELEAL-LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1150
Query: 950 XXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ T+++LK ++ + R + QL K + D E E E K
Sbjct: 1151 AEDAKLRLEVTVQALKTQHERDLQGR---DEAGEERRRQLAKQLRDAEVERDE---ERKQ 1204
Query: 1010 AGLSGKEMTAKTKLEKEIDEIRSKLS---KNDSEFTNEKNRLQTEIAKL-KDVNAKLEGD 1065
L+ + A+ KLE E++E++++++ + E + ++Q ++ +L ++V
Sbjct: 1205 RTLA---VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSR 1261
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEM 1094
+++F+ ++ E L + L EE+
Sbjct: 1262 EEIFSQNRES-EKRLKGLEAEVLRLQEEL 1289
Score = 53.6 bits (123), Expect = 7e-06
Identities = 171/839 (20%), Positives = 325/839 (38%), Gaps = 82/839 (9%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRK---RCERVEKEKSDILLRRLANIDTANKYTTGRSS 317
L++ + E+ Q +++V L K + E + D L + K
Sbjct: 596 LLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDG 655
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
E +LQ+++ E E+LR + L +K E+++ L R E R QL L A
Sbjct: 656 ESSELQEQMVEQQQRAEELRAQ---LGRKEEELQAAL-ARAEDEGGARA--QLLKSLREA 709
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
+ L + ED++ E + R D +E +LR ELE T+ +
Sbjct: 710 QAA---LAEAQEDLESE-----RVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQEL 761
Query: 438 LKKTERKADQ----LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
K E++ + LE+E HE + E+ G ++LEQ AR + A
Sbjct: 762 RSKREQEVTELKKTLEEETRIHEAAVQEL-RQRHGQALGELAEQLEQ--ARRGKGAWEKT 818
Query: 494 RELAEAN-SKFTGSNPSLMKVPQPETVKVSRSSLTR---GGSQEDPAQLLRDLQDSLERE 549
R EA S+ SL Q + R L G D + + + L+R
Sbjct: 819 RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA 878
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
E + A E A K + L K++ + +H+++ + +Q + +
Sbjct: 879 QAELENVSGALNE-AESKTIR----LSKELSS---TEAQLHDAQEL---LQEETRAKLAL 927
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
S ++ + + EE + + A L + R EE+ +L +
Sbjct: 928 GSRVRAMEAEAAGLREQLEEEAAARERAGREL--QTAQAQLSEWRRRQEEEAGALEAGEE 985
Query: 670 KMATKARSRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
AR + A K +++ + E D A M LE Q + L +K
Sbjct: 986 ARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD--LEQQRQLVSTLEKKQ 1043
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
+ +Q L ++ + + + A R+L+ + LE+E E
Sbjct: 1044 RKFDQ---LLAEEKAAVLRAVEERERAEAEGREREARALSL---------TRALEEE-QE 1090
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
R++L ER L AEL + L+ S+ D + +L+R +V EQ A+ LR
Sbjct: 1091 AREEL---ERQNRALRAEL-------EALLSSK--DDVGKSVHELERACRVAEQAANDLR 1138
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
A+ LE +E E+ KL+L ++L++ DL + + E + LAK
Sbjct: 1139 AQVTELE--DELTAAEDAKLRLEVTVQALKTQHERDLQGR--DEAGEERRRQLAKQLRDA 1194
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ +DE+ +++ A KK L+ + QA +K L +
Sbjct: 1195 EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREV 1254
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
+++ R + + +K ++ LE E+ + + + + ++ A+ ++ D
Sbjct: 1255 EETRTSR----EEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ--AQQDRDEMAD 1308
Query: 1029 EI-RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
E+ LSK + EK +L+ + +L++ + + + ++ ++Y+ L + +L+ +
Sbjct: 1309 EVANGNLSK--AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1365
Score = 52.8 bits (121), Expect = 1e-05
Identities = 99/495 (20%), Positives = 207/495 (41%), Gaps = 42/495 (8%)
Query: 650 LRKTAARVEEDNESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADPA 708
L+ A++EE+ L QL+ A A + + A K +E E E +
Sbjct: 471 LQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEEC 530
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELT-SKISSVTKTSAGSNTTARRSL 767
++ + E L++ ++ELE EA + ++L K+++ K L
Sbjct: 531 SRQM-----QTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLL--L 583
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE-----RLHAELSLA------QKKPKT 816
++KL++ER K+LED + E + E+E + RL E ++A +K+ K
Sbjct: 584 EDQNSKLSKER-KLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKG 642
Query: 817 LIKSRSLDAS-DQQNVDLKRQLQVIEQEASVLRA----KTQSLEADNEKLQTEN-KKLQL 870
+ L D ++ +L+ Q+ +Q A LRA K + L+A + + E + QL
Sbjct: 643 RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQL 702
Query: 871 LKN---AKSLRSDKALDLNTKKT--TQLENELKEALAKIKELEMICQDEKSEKKVRFTEA 925
LK+ A++ ++ DL +++ T+ E + ++ +++ L +D +
Sbjct: 703 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 762
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT 985
+K+E + + K+ L L + +++ + K T
Sbjct: 763 SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG----KGAWEKT 818
Query: 986 KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK 1045
+L L+ V +L E+ + + A G++ + +LE ++ E++ + +
Sbjct: 819 RLALEAEVSELRAELSSL----QTARQEGEQR--RRRLELQLQEVQGRAGDGERARAEAA 872
Query: 1046 NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLS 1105
+LQ A+L++V+ L + K L + + L + + L EE + + A +++
Sbjct: 873 EKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVR 932
Query: 1106 ADLKNATSLQTTMSD 1120
A A L+ + +
Sbjct: 933 AMEAEAAGLREQLEE 947
Score = 48.4 bits (110), Expect = 3e-04
Identities = 115/610 (18%), Positives = 201/610 (32%), Gaps = 47/610 (7%)
Query: 1221 RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE 1280
R EL +E +E + R + + + +E+ + E +++ HI++LE
Sbjct: 490 RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 549
Query: 1281 DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL 1340
L + V +L+ + LE AE S+
Sbjct: 550 AHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAA 609
Query: 1341 EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK 1400
E + L KL + ++L L E +L + +
Sbjct: 610 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 669
Query: 1401 DVKNKDAELA----TLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
+ A+L L+ L E GA A+ + L+ E + + + + L E+
Sbjct: 670 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLR-EAQAALAEAQEDLESERVART 728
Query: 1457 ELTGKYELLEEEHVVTKARL--TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAA 1514
+ + L EE + L T++ AQ EL +++ T L KTL+E+ AA
Sbjct: 729 KAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELK--KTLEEETRIHEAA 786
Query: 1515 WNTEKTEMQNSIASLQERL-----CGGGWEVERARLNARLDQRERELRAANDRRDVLEHH 1569
+ ++ L E+L G WE R L A + + EL + R E
Sbjct: 787 VQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQR 846
Query: 1570 HDXXXXXXXXXXXXXXDYER-----VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
D ER K+QR I S++
Sbjct: 847 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 906
Query: 1625 EI------------TDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSM 1672
E T K ++ M E L Q+ R+ + L+ AQ +
Sbjct: 907 EAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 966
Query: 1673 AEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKL---NTEL 1729
+E + R + + EE R + A ++ L L E +L L
Sbjct: 967 SEWRR-----RQEEEAGALEAGEEARRRAA---REAEALTQRLAEKTETVDRLERGRRRL 1018
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEE-----ERLLSSGRARVAGLATRMELAWHKERDEQQRL 1784
E A + L + + ++ E+ ++LL+ +A V E A + R+ + R
Sbjct: 1019 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1078
Query: 1785 LQETSTLARD 1794
L T L +
Sbjct: 1079 LSLTRALEEE 1088
Score = 42.3 bits (95), Expect = 0.017
Identities = 127/658 (19%), Positives = 260/658 (39%), Gaps = 59/658 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDIL-LRRLANIDTANKYTTGRSSEVL 320
+ S + D E L++E RV +++ LR + A + GR E+
Sbjct: 903 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGR--ELQ 960
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAET 379
Q +++E E+ + + R E E A+ T +++L
Sbjct: 961 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLER---GRRR 1017
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSL--------RRELEQTIKNC 431
L +EL D D++++ R L Q F + A+E +++ R E E +
Sbjct: 1018 LQQELDDATMDLEQQ-RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1076
Query: 432 RVLSFK--LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVA 489
R LS L++ + ++LE++ +L ++ D + + + ELE+ + + A
Sbjct: 1077 RALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKS--VHELERACRVAEQAA 1134
Query: 490 LRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE 549
L+ ++ E + T + + +++ TV+ ++ R D A ER
Sbjct: 1135 NDLRAQVTELEDELTAAEDAKLRLEV--TVQALKTQHERDLQGRDEA--------GEERR 1184
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
L +QLR+AE E ++ T + + + ++ AS
Sbjct: 1185 RQLAKQLRDAEVERDEERKQR---------------TLAVAARKKLEGELEELKAQMASA 1229
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
KE++ + +E + S + N R++ R++ +L +
Sbjct: 1230 GQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN--RESEKRLKGLEAEVLRLQE 1287
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
++A R+R+ + ++++ E AN N K + +++ L E+E + E
Sbjct: 1288 ELAASDRARRQAQQD-RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSE 1346
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNT---TARRSLTTNSNKLAEERVKVL---E 783
L L QV+ LT+++S+ SA + + R + +L EE +
Sbjct: 1347 LLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHK 1406
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQK---KPKTLIKSRSLDASDQQNVDLKRQLQVI 840
I + KL + E E+ E L+ K + + +K L +++ V + + Q+
Sbjct: 1407 MTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLE 1466
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
+ V + K Q EA+ E + + + +L + + + ++ A +N + TT L N L+
Sbjct: 1467 KGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV-TESAESMNREVTT-LRNRLR 1522
Score = 39.1 bits (87), Expect = 0.16
Identities = 74/358 (20%), Positives = 137/358 (38%), Gaps = 30/358 (8%)
Query: 172 MQLLKTQNSFEKEPSIEK-ERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRN 230
+Q LKTQ+ + + E E RR L+K D + R ++ + T + + K
Sbjct: 1162 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRT---LAVAARKKLEGE 1218
Query: 231 STNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERV 290
LK + + V+E + E + + KR + +
Sbjct: 1219 LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1278
Query: 291 EKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREI 350
E E L LA D A + E + +V + +EK+ L ++ ++
Sbjct: 1279 EAEVLR-LQEELAASDRARRQAQQDRDE---MADEVANGNLSKAAILEEKRQLEGRLGQL 1334
Query: 351 ESELETRPSTEAQTR--------QIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXX 402
E ELE S Q+E L +L A + + + +++++++L
Sbjct: 1335 EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1394
Query: 403 XXMQDNFREDQADEYSSLRRELEQTIKNC------RVLSFKL-KKTERKAD----QLEQE 451
R ++L +L Q + R+LS KL ++ E++ Q+E+E
Sbjct: 1395 GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE 1454
Query: 452 K--AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSN 507
+ A+ + LE G Q + +++E E+E +R+ RLQREL + N
Sbjct: 1455 RRVADQLRDQLE-KGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMN 1511
Score = 38.3 bits (85), Expect = 0.28
Identities = 83/401 (20%), Positives = 151/401 (37%), Gaps = 24/401 (5%)
Query: 168 RVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKN 227
R R+ + L + E+E +E ER++ + E E KD+ + ++ +V
Sbjct: 1072 REREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE 1131
Query: 228 SRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRC 287
+ L + ++ Q + E ++ L K+
Sbjct: 1132 QAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQL 1191
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN-EDLRDEKKHLTQK 346
E E+ + +R + A K G E+ + + LR + + +
Sbjct: 1192 RDAEVERDEERKQRTLAV-AARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKEL 1250
Query: 347 IREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQ 406
RE+E +R +Q R+ E+ R K L AE L L +E + R Q
Sbjct: 1251 WREVEETRTSREEIFSQNRESEK-RLKGLEAEVL--RLQEELAASDRARRQ------AQQ 1301
Query: 407 DNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGP 466
D R++ ADE ++ ++ R L +L + E ++LE+E++ E LL
Sbjct: 1302 D--RDEMADEVANGNLSKAAILEEKRQLEGRLGQLE---EELEEEQSNSE--LLNDRYRK 1354
Query: 467 DGMQRENRIKELEQE---VARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+Q E+ EL E A++ +L+R++ E + G + + T+
Sbjct: 1355 LLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL-GEEDAGARARHKMTIAALE 1413
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREAD--LREQLRNAEEE 562
S L + Q + R L L R A+ L+E + EEE
Sbjct: 1414 SKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE 1454
Score = 37.1 bits (82), Expect = 0.64
Identities = 88/407 (21%), Positives = 152/407 (37%), Gaps = 42/407 (10%)
Query: 182 EKEPSIEKERERRSLSKSKEDEKTARYKDERSSTK---DDVNFLMQVKNSRNSTNLKPPV 238
EK + E E S + ++ + KT R E SST+ D L+Q + +R L V
Sbjct: 873 EKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ-EETRAKLALGSRV 931
Query: 239 RGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLK----QEVDILR--KRCERVEK 292
R ++ Q Q+ + +E L + R
Sbjct: 932 RAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAA 991
Query: 293 EKSDILLRRLAN-IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIE 351
+++ L +RLA +T ++ GR +LQQ++++ T E R L +K R+ +
Sbjct: 992 REAEALTQRLAEKTETVDRLERGRR----RLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1047
Query: 352 SEL-----------ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXX 400
L E R EA+ R+ E A+ L+ EE + E+++++ R L
Sbjct: 1048 QLLAEEKAAVLRAVEERERAEAEGRERE---ARALSLTRALEEEQEAREELERQNRALRA 1104
Query: 401 XXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE--KAEHEKK 458
+ + D+ ELE+ CRV + +LE E AE K
Sbjct: 1105 ELEALLSS-----KDDVGKSVHELERA---CRVAEQAANDLRAQVTELEDELTAAEDAKL 1156
Query: 459 LLEIVGGPDGMQRENRIK---ELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ 515
LE+ Q E ++ E +E R LR + K + K +
Sbjct: 1157 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1216
Query: 516 PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
E ++ + G +E+ + LR +Q ++ E+ R + EE
Sbjct: 1217 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREE 1263
Score = 36.7 bits (81), Expect = 0.84
Identities = 32/102 (31%), Positives = 48/102 (47%), Gaps = 3/102 (2%)
Query: 1694 EEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
EE R K+ L + + E LL N++L E+ E RLAE S+ E EEE
Sbjct: 555 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE-EEE 613
Query: 1754 RLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
++ S + R+ AT ++ ++E+ R QE L R L
Sbjct: 614 KVKSLNKLRLKYEATIADMEDRLRKEEKGR--QELEKLKRRL 653
>U30872-1|AAA82935.1| 3113|Homo sapiens mitosin protein.
Length = 3113
Score = 83.4 bits (197), Expect = 7e-15
Identities = 182/870 (20%), Positives = 359/870 (41%), Gaps = 62/870 (7%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSE-VLKL---Q 323
E ++QI L +E ++L K E ++ S+ +L N+ A + E L+L Q
Sbjct: 2052 ELENQIAQLNKEKELLVKESESLQARLSESDYEKL-NVSKALEAALVEKGEFALRLSSTQ 2110
Query: 324 QKVNELTTHNEDLR-----DEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
++V++L E LR DEKK H+ +K++E E E ++ ++E L +L
Sbjct: 2111 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE------NDSLKDKVENLERELQM 2164
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
+E E ++ + E+ K E+ L M + + + D +LR E E K +
Sbjct: 2165 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD-LVTLRSEKENLTKQIQEKQG 2223
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR--ENRIKELEQEVAR---STEVALR 491
+L + ++ + E E+ ++I +N++KEL + VA E+
Sbjct: 2224 QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2283
Query: 492 LQREL---AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
++ L E + S L + + K L + E A LL+ ++LER
Sbjct: 2284 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKK-QLCVLQQLKESEHHADLLKGRVENLER 2342
Query: 549 EADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAA 607
E ++ R +A E N K + MT ++ ++ + T+ + +N
Sbjct: 2343 ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL-DVVTIRSEKEN-----L 2396
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL-L 666
+ KE+ L I ++ E ++ + +++E NE + L
Sbjct: 2397 TNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAAL 2456
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE--QEATVL 724
+ A KA+ + LS L +E A + DEA + L +N QE
Sbjct: 2457 HNDQEACKAKEQNLSSQVEC--LELEKAQLL--QGLDEAKNNYIVLQSSVNGLIQEVEDG 2512
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT-NSNKLAEERVKVLE 783
++K+E+ +++ LK Q+++ +S +++ ++L N E++++VL+
Sbjct: 2513 KQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2572
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ ++ L + + L EL L + + ++ ++ + +L+R++ + Q+
Sbjct: 2573 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK--VNKMTAKETELQREMHEMAQK 2630
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ L+ + L + +L E LQLL D+ +L T + ++L+ L
Sbjct: 2631 TAELQ---EELSGEKNRLAGE---LQLLLEEIKSSKDQLKEL-TLENSELKKSLDCMHKD 2683
Query: 904 IKELEMICQDEKSEKKVRFTEATKKET----DTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
E E ++E +E ++R EA KK DT K + +
Sbjct: 2684 QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKL 2743
Query: 960 T---LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
LKS K++ S K TK+ K V L+ E MK S K+
Sbjct: 2744 EIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ 2803
Query: 1017 MTAKTK-LEKEIDEIRS--KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ + + L+KE+ ++++ + K + + + L TEI +LK+ + + D + +KY
Sbjct: 2804 LEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKY 2863
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINK 1103
+L + L + L ++ + +Q +K
Sbjct: 2864 CSLLISHEKLEKAKEMLETQVAHLCSQQSK 2893
Score = 83.0 bits (196), Expect = 1e-14
Identities = 173/838 (20%), Positives = 351/838 (41%), Gaps = 100/838 (11%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAKLLAAET 379
+L+ K+NEL + E K K +E++ +LE + + + + + R +L+
Sbjct: 289 ELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKL 438
++ + ++++L+ L + N S R LEQ IK + +L
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQN--------AESARCSLEQKIKEKEKEFQEEL 400
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ +R L+QE + + +L + + Q +N L+ E+ + T V +L+ L E
Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQ-----ELQQAKNMHNVLQAELDKLTSVKQQLENNLEE 455
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
K + + + ++ + L R S E+ + L+ E++A ++ +
Sbjct: 456 FKQKLCRAEQAF------QASQIKENELRR--SMEEMKKENNLLKSHSEQKA---REVCH 504
Query: 559 AEEETANCKQ-VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E E N KQ +N +++ N ET+ +Q K I+ + EK
Sbjct: 505 LEAELKNIKQCLNQSQNFAEEMKAKNT------SQETMLRDLQEK-INQQENSLTLEKLK 557
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL--LQLKKMATKA 675
++K + +Q DL L H L ++ E+++++LL L+LKK +
Sbjct: 558 LAVADLEKQRDCSQ---DL--LKKREH-HIEQLNDKLSKTEKESKALLSALELKKKEYEL 611
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
+ K + ++ EKE ++ ++ L+ + ++ +V LE D+
Sbjct: 612 KEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDR 671
Query: 736 EALKKQVKEL------------TSKIS--SVTKTSAGSNTTARRSLTTNSNKLAE--ERV 779
E L +++ L T K++ + + + S+ ++ + K ++ +V
Sbjct: 672 ENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQV 731
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAEL----SLAQKKPKTLIKS----RSLDASDQQNV 831
+ LE ++ + ++++K+R + LHAE L + K +L+ + RSL A DQQ
Sbjct: 732 EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPA 791
Query: 832 DLKRQLQVIEQEASVLRAKTQ-SLEADNEK-----LQTENKKLQL-LKNAKSLRSDKALD 884
+I ++ S+ +++ LEAD LQ L+ L++ K + SD L
Sbjct: 792 MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD--LQ 849
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
++ Q++ E++E L K +++ E S++ + E T + +
Sbjct: 850 KQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 909
Query: 945 XXXXXXXXXXXXXQATLKSLK------DDAQKSFK---PRIPKKPTDLTTKLQL-KKMVE 994
QA ++ LK +D+ K + + + ++++ + L K+ +E
Sbjct: 910 KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE 969
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLE---KEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
+L E G + + NA L+ ++M K E IDE +S+ ++ EK L
Sbjct: 970 ELTQENGTLKEI--NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL--- 1024
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLS---NQCKTLTEEMKNREAQINKLSA 1106
+ + ++ E + KYKA + +NS L N+C +L E KN Q+ + A
Sbjct: 1025 LQRCEETGNAYED----LSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1078
Score = 83.0 bits (196), Expect = 1e-14
Identities = 170/871 (19%), Positives = 348/871 (39%), Gaps = 85/871 (9%)
Query: 314 GRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQ-KIREIESELETRPSTEAQTRQIE-QLR 371
G ++ LQ +V E T NE+LR H+ + + R++ES L +++ E QL
Sbjct: 1763 GNQEDIHNLQLRVKE--TSNENLR--LLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLM 1818
Query: 372 AKLLAA---ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ---AD-EYSSLRREL 424
K+ A E + EL EN D+ ++L + + +D E + +
Sbjct: 1819 TKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSR 1878
Query: 425 EQTIKNCRVLSFKLKK----TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQ 480
E N ++ K+ E + ++ EKA E + L + + +Q E E +
Sbjct: 1879 EDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN 1938
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
E +V + L+ EL+ S+ L + + T S + +QE +
Sbjct: 1939 E--NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSE 1996
Query: 541 DLQDSLEREADLREQLRNAEEETANCKQV--------NPPTFLDKQVMTDNIVTCDIHES 592
L EA+++E+ + +++ ++ L+K ++ C++
Sbjct: 1997 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2056
Query: 593 ETVTNSIQNKMIHAASTPSSK-EKSDSPPLSIDKT-----TEETQFHFDLPYLSIFNHMA 646
N + ++ + + ++ +SD L++ K E+ +F L H
Sbjct: 2057 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQL 2116
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDE-----K 700
+ K R+E D + L +K+ + R N + ++ + +N E
Sbjct: 2117 RRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDA 2176
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK--TSAG 758
E +A+ +K +E + V + L +KE L KQ++E ++S + K +S
Sbjct: 2177 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2236
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKL--------------------IEKER 798
S + + ++ V++L++++ E+ + + IE+E
Sbjct: 2237 SLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2296
Query: 799 DC----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ-- 852
E+L A L +KK +++ L S+ LK +++ +E+E + R +
Sbjct: 2297 QLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADLLKGRVENLERELEIARTNQEHA 2354
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ--LENELKEALAKIKELEMI 910
+LEA+N K + E K ++ +SLR + LD+ T ++ + L NEL++ +I ELE+I
Sbjct: 2355 ALEAENSKGEVETLKAKIEGMTQSLRGLE-LDVVTIRSEKENLTNELQKEQERISELEII 2413
Query: 911 CQD------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
EK ++KV+ E + + L+++ + L S
Sbjct: 2414 NSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2473
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL--ECEIGEMYVVMKNAGLSG--KEMTAK 1020
+ + + + L+ V L E E G+ + K+ +S ++ +
Sbjct: 2474 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ 2533
Query: 1021 TKLEKEIDEIRSK---LSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+L ++ ++ + + + E N L+ +I L+ NA L+ +V + YK LE
Sbjct: 2534 EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE 2593
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
NE + E++ A+ +L ++
Sbjct: 2594 NELELTKMDKMSFVEKVNKMTAKETELQREM 2624
Score = 82.6 bits (195), Expect = 1e-14
Identities = 178/923 (19%), Positives = 379/923 (41%), Gaps = 93/923 (10%)
Query: 648 NNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP 707
N LR + + +L +KM K + + + + + + A ++ E +
Sbjct: 1960 NQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLS 2019
Query: 708 AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA----GSNTTA 763
+++ LL+ + T L+ K++ LE+D +AL EL ++I+ + K S +
Sbjct: 2020 SDVSELLK----DKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ 2075
Query: 764 RRSLTTNSNKL----AEERVKVLEDE----IDEVRKKLIEKERDCERLHAELSLAQKKPK 815
R ++ KL A E V + E + ++++ + R E+L + +KK
Sbjct: 2076 ARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL 2135
Query: 816 TLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS--LEADNEKLQTENKKLQLLKN 873
+ + L +++N LK +++ +E+E + + L+A+N K + E K Q+ +
Sbjct: 2136 HI--AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM 2193
Query: 874 AKSLRSDKALDLNTKKTTQ--LENELKEALAKIKELEMICQ------DEKSEKKVRFTEA 925
A+SL+ + LDL T ++ + L +++E ++ EL+ + +EK + +++ E
Sbjct: 2194 ARSLKVFE-LDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2252
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS-LKDDAQ-----KSFKPRIP-- 977
+K + L+++ + +L ++++ Q + + R+
Sbjct: 2253 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2312
Query: 978 -KKPTDLTTKLQ--------LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKL 1023
KK + +L+ LK VE+LE E+ + + ++ G+ T K K+
Sbjct: 2313 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2372
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
E +R L + +EK L E+ K ++ ++LE F N + E E +
Sbjct: 2373 EGMTQSLRG-LELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQM 2431
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
+ T E ++ + ++N+ A L N +
Sbjct: 2432 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2491
Query: 1144 XQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXX 1203
+NY + N L++EV D +K+ R++ Q+ ++ V+
Sbjct: 2492 K--NNYIVLQSSVNGLIQEVEDGKQKL-------EKKDEEISRLKNQIQDQEQLVSKLS- 2541
Query: 1204 XXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKIT 1263
Q + ++EL + EL+ + +SK +L+ + L++ Y+N
Sbjct: 2542 -------QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN 2594
Query: 1264 SLESTIAAKDVHIKQLEDALRQTT---NDKYDEATSPVEM-VEMRXXXXXXXXXXXXXQD 1319
LE T K ++++ + T + ++ A E+ E+ +
Sbjct: 2595 ELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE 2654
Query: 1320 ELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE 1379
E+ ++K +L++ E+S K + + D + E + +++A
Sbjct: 2655 EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEK-KHQALL 2713
Query: 1380 LDTDLQSERK-KLDRMRIAHDKD-VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
LDT+ Q E + + R ++ ++ + ++ E+ LK + L + A + + ELK+
Sbjct: 2714 LDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2773
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYEL-------LEEEHVVTKARLT----VEKEQAQGE 1486
+ +K + K E E GK +L LEEE + + L+ +++Q G
Sbjct: 2774 MDNLKYVNQL----KKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGT 2829
Query: 1487 LLHVQ-KELSTALGEIK-TLQEK 1507
++ + EL+T + E+K TL+EK
Sbjct: 2830 VMDTKVDELTTEIKELKETLEEK 2852
Score = 81.8 bits (193), Expect = 2e-14
Identities = 156/813 (19%), Positives = 333/813 (40%), Gaps = 57/813 (7%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIEQLRA 372
+EV + + + L++ +L +K HL +K++ +E + + T+ E Q Q+ + +
Sbjct: 2006 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2065
Query: 373 KLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR 432
L+ + + E++ K + + F A SS + E+ Q +
Sbjct: 2066 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEF----ALRLSSTQEEVHQLRRGIE 2121
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV----ARSTEV 488
L +++ E+K + ++ E E++ + + ++RE ++ E QE+ A +++
Sbjct: 2122 KLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKA 2181
Query: 489 ALR-LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
+ L+ ++ E L+ + + E +++ + G + +LL + LE
Sbjct: 2182 EVETLKTQIEEMARSLKVFELDLVTL-RSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE 2240
Query: 548 R----EADLREQLRNAEEETAN-CKQVNPPTFL---DKQVM--TDNIVTCDIHESETVTN 597
E ++E+ + A E N K++N D+++M T+ + I E + N
Sbjct: 2241 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 2300
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN-----HMAANNLRK 652
SI+ + E + L + + +E++ H DL + N +A N
Sbjct: 2301 SIE-------KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH 2353
Query: 653 TAARVEEDN---ESLLLQLKKMATKARSRKLS-PTPPANKLSIETANDNDEKETDEADPA 708
A E E+L +++ M R +L T + K ++ +++ E +
Sbjct: 2354 AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEII 2413
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
L E+E ++ K E+ E L+ Q+KEL +++++ ++L+
Sbjct: 2414 NSSFENILQEKEQEKVQMK-EKSSTAMEMLQTQLKELNERVAALHNDQEACK-AKEQNLS 2471
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA-QKKPKTLIKSRSLDASD 827
+ L E+ ++L+ +DE + I + L E+ QK K + L
Sbjct: 2472 SQVECLELEKAQLLQG-LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 2530
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
Q L +L +E E + K Q+LE N ++ E +K+Q+L++ + D L++
Sbjct: 2531 QDQEQLVSKLSQVEGEHQLW--KEQNLELRNLTVELE-QKIQVLQSKNASLQD-TLEVLQ 2586
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
LENEL+ L K+ ++ + ++ ++ + TE ++ + +
Sbjct: 2587 SSYKNLENELE--LTKMDKMSFV--EKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2642
Query: 948 XXXXXXXXXXQATLKSLKDDAQK-SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVV 1006
+KS KD ++ + + KK D K Q++K + E EI E +
Sbjct: 2643 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE-EIAEYQLR 2701
Query: 1007 MKNAGLSGKEMTAKT--KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ A + + T + E EI R KL+ + +++K + + +++N L+
Sbjct: 2702 LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2761
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNR 1097
+ + K + +N NQ K E + +
Sbjct: 2762 TTQIL-EELKKTKMDNLKYVNQLKKENERAQGK 2793
Score = 73.7 bits (173), Expect = 6e-12
Identities = 137/706 (19%), Positives = 284/706 (40%), Gaps = 47/706 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE + + + LK +V+ L + + E+ + ++L A A T E +
Sbjct: 2137 IAEKLKERERENDSLKDKVENLERELQMSEENQELVILD--AENSKAEVETLKTQIEEMA 2194
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIE---SELETRPST------EAQTRQIEQLRA 372
KV EL LR EK++LT++I+E + SEL+ S+ E + +I+
Sbjct: 2195 RSLKVFELDLVT--LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2252
Query: 373 KLLAAETLCEELMDENEDMKKELRD---LXXXXXXMQDNFREDQA--DEYSSLRRELEQT 427
A E L +L + NE + D + + E+ + LR LE
Sbjct: 2253 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2312
Query: 428 IKNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQREN---RIKELEQEV 482
K + +LK++E AD L+ E E E ++ ++ EN ++ L+ ++
Sbjct: 2313 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2372
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP-ETVKVSRSSLTRGGSQEDPAQLLRD 541
T+ L+ ++ S+ L K + +++ SS +++ ++
Sbjct: 2373 EGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2432
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---S 598
+ S E L+ QL+ E A +Q ++ + ++ +++ + +
Sbjct: 2433 EKSSTAMEM-LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2491
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEE-----TQFHFDLPYLSIFNHMAANNLRKT 653
N ++ +S ++ + ++K EE Q +S + + +
Sbjct: 2492 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2551
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+E N ++ L+ K ++++ L T ++++ N E E + +M +
Sbjct: 2552 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEV----LQSSYKNLENELELTKMDKMSFV 2607
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
++N+ A K EL+++ + ++ EL ++S AG + ++ ++
Sbjct: 2608 EKVNKMTA-----KETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2662
Query: 774 LAEERVK--VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
L E ++ L+ +D + K +EKE AE L + + ++ LD + Q V
Sbjct: 2663 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2722
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL-NTKKT 890
+++ + + + L +Q LE D K E L + L K + N K
Sbjct: 2723 EIQTYREKLTSKEECL--SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYV 2780
Query: 891 TQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
QL+ E + A K+K L C+ + EK++ E ++ + K K
Sbjct: 2781 NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK 2826
Score = 71.3 bits (167), Expect = 3e-11
Identities = 195/1097 (17%), Positives = 402/1097 (36%), Gaps = 60/1097 (5%)
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
++ D ++L ++ E L +E+ ++ E+L ++KEL SK+ + + +
Sbjct: 1764 NQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLH-LQEVQLMTKIE 1822
Query: 763 ARRSLTTNSNKLAEERVKVLE--DEIDEVRKKLIEKERDCERLHAELSL-AQKKPKTLIK 819
A L +L +E + E + ++L+++ E L+++L + A K + I
Sbjct: 1823 ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIG 1882
Query: 820 SRSLDASD---QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
+D ++ +D++ +L I E + + + LEAD E +QTE KL L K+ ++
Sbjct: 1883 DNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE--KLCLEKDNEN 1940
Query: 877 LRS-----DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
+ ++ L + T + QL EL K L+ + EK ++K + E +++
Sbjct: 1941 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL--SEKMKEKTQ--ELESHQSE 1996
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS---LKDDAQKSFKPRIPKKPTDLTTKLQ 988
L Q LK L++ Q K T + Q
Sbjct: 1997 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2056
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKE-MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+ ++ ++ E + E + S E + LE + E + + + S E ++
Sbjct: 2057 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE-KGEFALRLSSTQEEVHQ 2115
Query: 1048 LQTEIAKLKDVNAKLEGDKDV-FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
L+ I KL+ V + + K + A K K E EN +L ++ + L E++ E +
Sbjct: 2116 LRRGIEKLR-VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVIL 2174
Query: 1107 DLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDK 1166
D +N+ + T+ + +N TK Q+K L E+
Sbjct: 2175 DAENSKAEVETLK---TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKL 2231
Query: 1167 TKKIGDXXXXXXXXXXXCKRIEK-QLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-- 1223
K K + ++++ ++ T + L
Sbjct: 2232 LSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPP 2291
Query: 1224 IE----LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
IE L + ++L+AR E K + + ++++ + + +E+ ++
Sbjct: 2292 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2351
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
E A + N K + T ++ M + E N +L+K + S +
Sbjct: 2352 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2411
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
+ + ++ L + E + E L ++++
Sbjct: 2412 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLS 2471
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS------LALEKA 1453
V+ + E A L L + N + L QE E+ +KLE L +
Sbjct: 2472 SQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ 2531
Query: 1454 EYEELTGKYELLEEEHVVTKAR------LTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
+ E+L K +E EH + K + LTVE EQ L L L +++ +
Sbjct: 2532 DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2591
Query: 1508 LGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
L E +K E N + + + L E+ + + + + R A + +
Sbjct: 2592 LENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQL 2651
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
+LE + + + + + ++EK +A
Sbjct: 2652 LLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQA 2711
Query: 1625 EITDTKTRYEGQMNTMRDELKSLHN-------QVSRFRRERDNYKQMLEAAQKSMAEIKN 1677
+ DT +YE ++ T R++L S ++ + ++ L+A + + E+K
Sbjct: 2712 LLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2771
Query: 1678 GDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA- 1736
+ N + + E + K+ LL + LE+E + S+L +K+
Sbjct: 2772 TKMDNLKYVNQLKK-ENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV 2830
Query: 1737 -EVRLAEMQSRLNEYEE 1752
+ ++ E+ + + E +E
Sbjct: 2831 MDTKVDELTTEIKELKE 2847
Score = 67.7 bits (158), Expect = 4e-10
Identities = 182/903 (20%), Positives = 356/903 (39%), Gaps = 79/903 (8%)
Query: 289 RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ-KVNELTTHNEDLRDE----KKHL 343
+ E +K + ++L N K R+ + + Q K NEL E+++ E K H
Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
Query: 344 TQKIREI---ESELETRPSTEAQTRQI-EQLRAKLLAAETLCEELMD-----EN----ED 390
QK RE+ E+EL+ Q++ E+++AK + ET+ +L + EN E
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
+K + DL QD ++ + L +L +T K + L L+ +++ + E+
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKRE-HHIEQLNDKLSKTEKESKALLSALELKKKEYELKEE 614
Query: 451 E------KAEHEKKLLEIVGGPDGMQRE-NRIKE-LEQEVARSTEVALRLQRELAEANSK 502
+ K+E+EK L ++ + +Q + N ++ L+ + +S E R+ R L
Sbjct: 615 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERV-RTLEMDREN 673
Query: 503 FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
+ +L V ++V+V L Q+ + Q +E QL E+
Sbjct: 674 LSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 733
Query: 563 TANCKQVNPPTFLDK-----------QVMTD-------NIVTCDIHESETVTNSIQNKMI 604
+ Q+ +DK + + D ++VT + H+ + Q M
Sbjct: 734 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 793
Query: 605 HA--------ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN-LRKTAA 655
H+ S PS + + K + Q D S+ + N+ L+K
Sbjct: 794 HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 853
Query: 656 RVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLLL 714
+ + + L K +S + +KL +T A+ N ET A + K L
Sbjct: 854 ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ 913
Query: 715 ELNEQEATVLRRKVEELEQDKEALKKQVKELT--SKISSVTKTSAGS----NTTARRSLT 768
LN++ T + +++EL++ L+ +KEL S+ S+ K S N LT
Sbjct: 914 LLNDKVETE-QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELT 972
Query: 769 TNSNKLAEERVKVLEDEIDEVRKK--LIEKERDCERLHAELSLAQKKPKTLIKSRSLDAS 826
+ L E + +++++ ++K + E+ +ELS K+ K ++ R +
Sbjct: 973 QENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETG 1032
Query: 827 DQQNVDLKRQLQVIEQEASVLRAKTQSLEA--DNEKLQTENKKLQLLKNAKSLRSDKALD 884
+ DL ++ + +++ S L + +N K + E K K + + A
Sbjct: 1033 NAYE-DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFA 1091
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
+ LE E + + E+ + KSE K+E TLK +Q
Sbjct: 1092 EERNQNLMLELETVQQALR-SEMTDNQNNSKSE-----AGGLKQEIMTLKEEQNKMQKEV 1145
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEIG 1001
T ++ + + + ++ ++ K Q+ V+++ +
Sbjct: 1146 NDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSY 1205
Query: 1002 EMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
+V A L KE+ + ++ EKE + + + D E +N ++ EI+ LKD
Sbjct: 1206 NAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEI 1265
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD-LKNATSLQTTMS 1119
E ++ +N+N++L +T ++ E L A+ + T L + S
Sbjct: 1266 DAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRS 1325
Query: 1120 DCM 1122
+C+
Sbjct: 1326 ECI 1328
Score = 56.8 bits (131), Expect = 7e-07
Identities = 142/786 (18%), Positives = 304/786 (38%), Gaps = 38/786 (4%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
QK+ EL + L+ EK+ Q+ +++S LE P + Q + E+ L E +
Sbjct: 18 QKIQELEGQLDKLKKEKQ---QRQFQLDS-LEAAPQKQTQKVENEKTEGTNLKREN--QR 71
Query: 384 LMDENEDMKKELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
LM+ E ++K + + + NF+E Q + +LEQ +K C+ + ++
Sbjct: 72 LMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQA 131
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+ AD + +K+ P ++ ++L+++ + E RL+ E+ +
Sbjct: 132 AQSAD-VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE-DPAQLLRDLQDSLEREADLREQLRNAE 560
K + + + SS QE P+ L + Q + R D + E
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR-DFSASYFSGE 249
Query: 561 EETANCKQVNPPTFLD-KQVMTDNIVTCDIHESETVTN-SIQNKMIHAASTPSSKEKSDS 618
+E + D DN + + + N ++NK+ EK
Sbjct: 250 QEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMK 309
Query: 619 PPLSIDKTTEETQFHFDLPYLSIF-NHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
++ +E Q + + + N R R + K A + +
Sbjct: 310 GQVN---KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQ--ASTKYTALEQKL 364
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEA 737
+KL+ + + E+A + E++ E E + EL+ Q+ + + +E Q K
Sbjct: 365 KKLTEDLSCQRQNAESARCSLEQKIKE---KEKEFQEELSRQQRS-FQTLDQECIQMKAR 420
Query: 738 LKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKE 797
L +++++ + +V + T+ ++ L N + ++ + E + K E
Sbjct: 421 LTQELQQ-AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRA-EQAFQASQIKENELR 478
Query: 798 RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD 857
R E + E +L + + K+R + + + ++K+ L + A ++AK S E
Sbjct: 479 RSMEEMKKENNLLKSHSEQ--KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536
Query: 858 NEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE-LKEALAKIKEL-EMICQDEK 915
LQ +K+ +N+ +L K + +K + LK+ I++L + + + EK
Sbjct: 537 LRDLQ---EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEK 593
Query: 916 SEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
K + KK+ LK ++ + L+S + + K +
Sbjct: 594 ESKALLSALELKKKEYELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 653
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLS 1035
K L+ E+L EI ++ V L K + +T+ + E++ K
Sbjct: 654 QIKSHEYNERVRTLEMDRENLSVEIRNLHNV-----LDSKSVEVETQ-KLAYMELQQKAE 707
Query: 1036 KNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+D + E + + ++L LE + +N+ + +L + ++L + +K
Sbjct: 708 FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 767
Query: 1096 NREAQI 1101
+++A +
Sbjct: 768 SKDASL 773
Score = 49.6 bits (113), Expect = 1e-04
Identities = 87/439 (19%), Positives = 188/439 (42%), Gaps = 53/439 (12%)
Query: 270 QDQIEGLKQEVDI----LRKRCERVEKEKSDI-----LLRRLANIDTANKYTTGRSSEV- 319
Q + GL QEV+ L K+ E + + K+ I L+ +L+ ++ ++ ++ E+
Sbjct: 2499 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2558
Query: 320 ---LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
++L+QK+ L + N L+D + L + +E+ELE T+ + K+ A
Sbjct: 2559 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELEL---TKMDKMSFVEKVNKMTA 2615
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
ET EL E +M ++ +L ++ A E L E++ + + L+
Sbjct: 2616 KET---ELQREMHEMAQKTAELQEELSGEKNRL----AGELQLLLEEIKSSKDQLKELTL 2668
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE-VARSTEVALRLQRE 495
+ + ++ D + +++ E E K+ E + + + R+ E E++ A + + + E
Sbjct: 2669 ENSELKKSLDCMHKDQVEKEGKVREEIA-----EYQLRLHEAEKKHQALLLDTNKQYEVE 2723
Query: 496 LAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQ----DSLEREA 550
+ K T L + + +K S+ L S + Q+L +L+ D+L+
Sbjct: 2724 IQTYREKLTSKEECLSSQKLEIDLLKSSKEEL--NNSLKATTQILEELKKTKMDNLKYVN 2781
Query: 551 DLREQLRNAEEE----TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHA 606
L+++ A+ + +CKQ+ +K+++ + + + T ++ + +
Sbjct: 2782 QLKKENERAQGKMKLLIKSCKQLEE----EKEILQKELSQLQAAQEKQKTGTVMDTKVDE 2837
Query: 607 ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
+T + K ++++ T+E + D Y S+ ++ L K +E L
Sbjct: 2838 LTTEIKELKE-----TLEEKTKEADEYLD-KYCSLL--ISHEKLEKAKEMLETQVAHLCS 2889
Query: 667 QLKKMATKARSRKLSPTPP 685
Q K ++ S L P P
Sbjct: 2890 QQSKQDSRG-SPLLGPVVP 2907
Score = 48.0 bits (109), Expect = 3e-04
Identities = 114/585 (19%), Positives = 226/585 (38%), Gaps = 40/585 (6%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLED 784
++++E+LEQ+ + K ++ E + + + S T ++ TT ED
Sbjct: 108 KKQIEKLEQELKRCKSEL-ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED 166
Query: 785 EIDEVRKKLIEKER---DCERLHAELSLAQKKPKTLIKSRSL---DASDQ----QNVDLK 834
++ K++ E++R + + L A+ + +Q P+ + R + AS Q
Sbjct: 167 LKEKYNKEVEERKRLEAEVKALQAKKA-SQTLPQATMNHRDIARHQASSSVFSWQQEKTP 225
Query: 835 RQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK-NAKSLRSDKALDLNTKKTTQL 893
L Q + R + S + +++ LQ+ K +A S D + + QL
Sbjct: 226 SHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL--LDQL 283
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK-QXXXXXXXXXXXXXXX 952
+ + +E KI ELE+ Q + E K + + + + K+K +
Sbjct: 284 KAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDEL 343
Query: 953 XXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE-DLECEIGEMYVVMKNAG 1011
Q S K A + ++ K DL+ + Q + LE +I E +
Sbjct: 344 VRTTAQYDQASTKYTA---LEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEE- 399
Query: 1012 LSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFAN 1071
LS ++ + +T L++E +++++L++ + N N LQ E+ KL V +LE + + F
Sbjct: 400 LSRQQRSFQT-LDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
Query: 1072 KYKALEN--ENSNL-SNQCKTLTEEMKNREAQINKLSAD-LKNATSLQTTMSDCMXXXXX 1127
K E + S + N+ + EEMK + S + L+ + +
Sbjct: 459 KLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQ 518
Query: 1128 XXXXXXXXXXXXXXXXXQV-DNYTKIDQDKNKLLKEVGDKTK-KIGDXXXXXXXXXXXCK 1185
+ D KI+Q +N L E K K + D K
Sbjct: 519 SQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE---KLKLAVADLEKQRDCSQDLLK 575
Query: 1186 RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI 1245
+ E + D+++ +A++ A ++ EL EK + E
Sbjct: 576 KREHHIEQLNDKLS-----KTEKESKALLSALELKKKEYELKEEKTLFSCWKSENEKLLT 630
Query: 1246 TLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK 1290
+E+E K + ++KI LE+ + + + + + +R D+
Sbjct: 631 QMESE----KENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDR 671
Score = 44.4 bits (100), Expect = 0.004
Identities = 53/261 (20%), Positives = 112/261 (42%), Gaps = 19/261 (7%)
Query: 154 QTQLAITKND--SLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYK-- 209
+ +L +TK D S E+V KM +T+ E +K E + +++ +
Sbjct: 2593 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2652
Query: 210 -DERSSTKDDVNFLM----QVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXX----XX 260
+E S+KD + L ++K S + + + G
Sbjct: 2653 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2712
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
L+D+N K+Y+ +I+ ++++ ++ C +K + D+L ++ + K TT E+
Sbjct: 2713 LLDTN-KQYEVEIQTYREKLTS-KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK 2770
Query: 321 KLQQK----VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
K + VN+L NE + + K L + +++E E E +Q + ++ +
Sbjct: 2771 KTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV 2830
Query: 377 AETLCEELMDENEDMKKELRD 397
+T +EL E +++K+ L +
Sbjct: 2831 MDTKVDELTTEIKELKETLEE 2851
Score = 44.0 bits (99), Expect = 0.006
Identities = 170/870 (19%), Positives = 353/870 (40%), Gaps = 84/870 (9%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
++ + V + +E KQ L+K+CE + + K +I + + S +
Sbjct: 826 ILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS 885
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
KLQ+ + + H + + L K +E++ L + TE Q E ++ L ++L
Sbjct: 886 KLQE---DTSAHQNVVAETLSALENKEKELQL-LNDKVETE-QAEIQELKKSNHLLEDSL 940
Query: 381 CE-ELMDENEDM-KKELRDLXXXXXXMQDNFREDQA---DEYSSLRRELEQTIKNCRVLS 435
E +L+ E + KKE+ + + ++ + +SL +E I+ +
Sbjct: 941 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1000
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
+ + E+ +L + + + LL+ + N ++L Q+ + E +L+
Sbjct: 1001 NYIDEREKSISELSDQYKQEKLILLQRC-----EETGNAYEDLSQKYKAAQEKNSKLECL 1055
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ-LLRDLQDSLER-EADLR 553
L E S L ++ + K + LT+ E+ Q L+ +L+ + +++
Sbjct: 1056 LNECTSLCENRKNELEQLKE-AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1114
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
+ N++ E KQ T ++Q V + E+E + ++ K H S+
Sbjct: 1115 DNQNNSKSEAGGLKQ-EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK--HECQNLESE 1171
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN-ESLLLQLKKMA 672
+S ++ +E Q +F P + + V+E + +S QL ++
Sbjct: 1172 PIRNSVK---ERESERNQCNFK-PQMDL--------------EVKEISLDSYNAQLVQLE 1213
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE 732
R+++L + E E +T D E L ++ QE + L K E++
Sbjct: 1214 AMLRNKELK----LQESEKEKECLQHELQTIRGD-LETSNLQDMQSQEISGL--KDCEID 1266
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERV-KVLEDEIDEVR 790
+++ + + TS+ N + SL T NKL E E++ ++L+ E E+
Sbjct: 1267 AEEKYISGPHELSTSQ---------NDNAHLQCSLQTTMNKLNELEKICEILQAEKYELV 1317
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSL-DASDQQNVDLKRQL---QVIEQEASV 846
+L + +C + A +A++ K L + + L D S + +L + + EQ
Sbjct: 1318 TELNDSRSEC--ITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQ 1375
Query: 847 LRAKTQSLEADN--EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
L+ N E L +K++Q+ + L+ +K L L ++ L ++ + +K+
Sbjct: 1376 HPVSLAPLDESNSYEHLTLSDKEVQM--HFAELQ-EKFLSLQSEHKI-LHDQHCQMSSKM 1431
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
EL+ K+E V T + D +K Q ++L SL
Sbjct: 1432 SELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQ--LGLEEGLVPSLSSSCVPDSSSLSSL 1489
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYV-VMKNAGLSGKEM-TAKTK 1022
D SF + ++ D++ L+ V +C + E++ ++ L+ KE +A K
Sbjct: 1490 GD---SSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAK 1546
Query: 1023 LEKEIDEI----RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALEN 1078
+E++ + R L K + + ++ EI +L+ + + + D +Y +
Sbjct: 1547 GVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYL---S 1603
Query: 1079 ENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
EN + ++T EM+++ A K + L
Sbjct: 1604 ENEQWQQKLTSVTLEMESKLAAEKKQTEQL 1633
Score = 39.9 bits (89), Expect = 0.091
Identities = 37/166 (22%), Positives = 72/166 (43%), Gaps = 11/166 (6%)
Query: 1617 QSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIK 1676
Q+ + ++ E+ + + + N ++ + +V E N KQ L +Q E+K
Sbjct: 468 QASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK 527
Query: 1677 NGDKSARIHRNSI--------SSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
+ S + +S E+ + VA LE+Q C +D L + +LN +
Sbjct: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
Query: 1729 LVSEKSSAEVRLAEMQSRLNEY---EEERLLSSGRARVAGLATRME 1771
L + ++ L+ ++ + EY EE+ L S ++ L T+ME
Sbjct: 588 LSKTEKESKALLSALELKKKEYELKEEKTLFSCWKSENEKLLTQME 633
Score = 39.1 bits (87), Expect = 0.16
Identities = 85/406 (20%), Positives = 168/406 (41%), Gaps = 48/406 (11%)
Query: 1376 KAKELDTDLQSERKK-LDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK 1434
K KE +L+S + + L +++A + +VK K L TL + L ++ T L
Sbjct: 1982 KMKEKTQELESHQSECLHCIQVA-EAEVKEKTELLQTLSSDVSELLKDK-------THL- 2032
Query: 1435 QEYEETVKKLEHSLALEKAEYE----ELTGKYELLEEEHVVTKARLTVEKEQAQGELLHV 1490
QE ++++K +L+L K E E +L + ELL +E +ARL+ ++ E L+V
Sbjct: 2033 QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLS----ESDYEKLNV 2088
Query: 1491 QKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD 1550
K L AL E + + ++ E +++ I L+ R+ E ++ + +L
Sbjct: 2089 SKALEAALVE----KGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD--EKKQLHIAEKLK 2142
Query: 1551 QRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXX 1610
+RERE + D+ + LE + + + Q
Sbjct: 2143 ERERENDSLKDKVENLER-----------------ELQMSEENQELVILDAENSKAEVET 2185
Query: 1611 XXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
IE+ ++ K D T + + +++ Q+S + ++K +LE ++
Sbjct: 2186 LKTQIEEMARSLKVFELDLVT-LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ 2244
Query: 1671 SMAEIKNGDKSA-RIHRNSISSTDE--EEYRNKVALLEQQVACLEDELCESRLLASKLNT 1727
+ +IK K+A + +N + +E +++ L+ + E L + +
Sbjct: 2245 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2304
Query: 1728 ELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA 1773
++ + +L +Q +L E E L G RV L +E+A
Sbjct: 2305 LRARLEADEKKQLCVLQ-QLKESEHHADLLKG--RVENLERELEIA 2347
Score = 38.3 bits (85), Expect = 0.28
Identities = 61/305 (20%), Positives = 126/305 (41%), Gaps = 29/305 (9%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYE---NKITSLESTIAAKDVHIKQL-- 1279
+LT + ++L+ + ++ + + +DL A+YE + + S ++++ + H + L
Sbjct: 726 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 785
Query: 1280 ---EDALRQT-TNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
+ A+ + N ++ + P E E R Q+ +++ + LE + +
Sbjct: 786 FDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMN 845
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD---------LQS 1386
S + + +L ++E +S +K +E DT L +
Sbjct: 846 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE-DTSAHQNVVAETLSA 904
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
K +++ +DK V+ + AE+ LK +LE + K + L + K++
Sbjct: 905 LENKEKELQLLNDK-VETEQAEIQELKKSNHLLEDS----LKELQLLSETLSLEKKEMSS 959
Query: 1447 SLALEKAEYEELTGKYELLEEEHV---VTKARLTVEKEQAQGELLHVQKELSTALGEIKT 1503
++L K E EELT + L+E + K L + E + +K +S + K
Sbjct: 960 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYK- 1018
Query: 1504 LQEKL 1508
QEKL
Sbjct: 1019 -QEKL 1022
Score = 37.5 bits (83), Expect = 0.48
Identities = 65/342 (19%), Positives = 134/342 (39%), Gaps = 14/342 (4%)
Query: 1228 SEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTT 1287
S+ ++L+ ++ K + LEAE++ L+A ++ T ++T+ +D+ Q ++
Sbjct: 162 SKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQ-TLPQATMNHRDIARHQASSSVFSWQ 220
Query: 1288 NDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS-----AAKLEM 1342
+K S + + + +++ K +A SS ++ +
Sbjct: 221 QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280
Query: 1343 AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK-- 1400
QLK+ +L N NK +EL L+ + +L +K
Sbjct: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCR 340
Query: 1401 -DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
++ A+ K LEQ + ++ +Q E LE + ++ E++E
Sbjct: 341 DELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEEL 400
Query: 1460 GK----YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT-ESAA 1514
+ ++ L++E + KARLT E +QA+ +Q EL + L+ L +
Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL 460
Query: 1515 WNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQREREL 1556
E+ + I + R + E L + +Q+ RE+
Sbjct: 461 CRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREV 502
>AL445666-1|CAH71810.1| 3114|Homo sapiens centromere protein F,
350/400ka (mitosin) protein.
Length = 3114
Score = 83.4 bits (197), Expect = 7e-15
Identities = 182/870 (20%), Positives = 359/870 (41%), Gaps = 62/870 (7%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSE-VLKL---Q 323
E ++QI L +E ++L K E ++ S+ +L N+ A + E L+L Q
Sbjct: 2053 ELENQIAQLNKEKELLVKESESLQARLSESDYEKL-NVSKALEAALVEKGEFALRLSSTQ 2111
Query: 324 QKVNELTTHNEDLR-----DEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
++V++L E LR DEKK H+ +K++E E E ++ ++E L +L
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE------NDSLKDKVENLERELQM 2165
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
+E E ++ + E+ K E+ L M + + + D +LR E E K +
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD-LVTLRSEKENLTKQIQEKQG 2224
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR--ENRIKELEQEVAR---STEVALR 491
+L + ++ + E E+ ++I +N++KEL + VA E+
Sbjct: 2225 QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284
Query: 492 LQREL---AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
++ L E + S L + + K L + E A LL+ ++LER
Sbjct: 2285 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKK-QLCVLQQLKESEHHADLLKGRVENLER 2343
Query: 549 EADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAA 607
E ++ R +A E N K + MT ++ ++ + T+ + +N
Sbjct: 2344 ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL-DVVTIRSEKEN-----L 2397
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL-L 666
+ KE+ L I ++ E ++ + +++E NE + L
Sbjct: 2398 TNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAAL 2457
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE--QEATVL 724
+ A KA+ + LS L +E A + DEA + L +N QE
Sbjct: 2458 HNDQEACKAKEQNLSSQVEC--LELEKAQLL--QGLDEAKNNYIVLQSSVNGLIQEVEDG 2513
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT-NSNKLAEERVKVLE 783
++K+E+ +++ LK Q+++ +S +++ ++L N E++++VL+
Sbjct: 2514 KQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ ++ L + + L EL L + + ++ ++ + +L+R++ + Q+
Sbjct: 2574 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK--VNKMTAKETELQREMHEMAQK 2631
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ L+ + L + +L E LQLL D+ +L T + ++L+ L
Sbjct: 2632 TAELQ---EELSGEKNRLAGE---LQLLLEEIKSSKDQLKEL-TLENSELKKSLDCMHKD 2684
Query: 904 IKELEMICQDEKSEKKVRFTEATKKET----DTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
E E ++E +E ++R EA KK DT K + +
Sbjct: 2685 QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKL 2744
Query: 960 T---LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
LKS K++ S K TK+ K V L+ E MK S K+
Sbjct: 2745 EIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ 2804
Query: 1017 MTAKTK-LEKEIDEIRS--KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ + + L+KE+ ++++ + K + + + L TEI +LK+ + + D + +KY
Sbjct: 2805 LEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKY 2864
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINK 1103
+L + L + L ++ + +Q +K
Sbjct: 2865 CSLLISHEKLEKAKEMLETQVAHLCSQQSK 2894
Score = 83.0 bits (196), Expect = 1e-14
Identities = 170/871 (19%), Positives = 348/871 (39%), Gaps = 85/871 (9%)
Query: 314 GRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQ-KIREIESELETRPSTEAQTRQIE-QLR 371
G ++ LQ +V E T NE+LR H+ + + R++ES L +++ E QL
Sbjct: 1764 GNQEDIHNLQLRVKE--TSNENLR--LLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLM 1819
Query: 372 AKLLAA---ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ---AD-EYSSLRREL 424
K+ A E + EL EN D+ ++L + + +D E + +
Sbjct: 1820 TKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSR 1879
Query: 425 EQTIKNCRVLSFKLKK----TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQ 480
E N ++ K+ E + ++ EKA E + L + + +Q E E +
Sbjct: 1880 EDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN 1939
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
E +V + L+ EL+ S+ L + + T S + +QE +
Sbjct: 1940 E--NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSE 1997
Query: 541 DLQDSLEREADLREQLRNAEEETANCKQV--------NPPTFLDKQVMTDNIVTCDIHES 592
L EA+++E+ + +++ ++ L+K ++ C++
Sbjct: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2057
Query: 593 ETVTNSIQNKMIHAASTPSSK-EKSDSPPLSIDKT-----TEETQFHFDLPYLSIFNHMA 646
N + ++ + + ++ +SD L++ K E+ +F L H
Sbjct: 2058 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQL 2117
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDE-----K 700
+ K R+E D + L +K+ + R N + ++ + +N E
Sbjct: 2118 RRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDA 2177
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK--TSAG 758
E +A+ +K +E + V + L +KE L KQ++E ++S + K +S
Sbjct: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2237
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKL--------------------IEKER 798
S + + ++ V++L++++ E+ + + IE+E
Sbjct: 2238 SLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2297
Query: 799 DC----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ-- 852
E+L A L +KK +++ L S+ LK +++ +E+E + R +
Sbjct: 2298 QLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADLLKGRVENLERELEIARTNQEHA 2355
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ--LENELKEALAKIKELEMI 910
+LEA+N K + E K ++ +SLR + LD+ T ++ + L NEL++ +I ELE+I
Sbjct: 2356 ALEAENSKGEVETLKAKIEGMTQSLRGLE-LDVVTIRSEKENLTNELQKEQERISELEII 2414
Query: 911 CQD------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
EK ++KV+ E + + L+++ + L S
Sbjct: 2415 NSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL--ECEIGEMYVVMKNAGLSG--KEMTAK 1020
+ + + + L+ V L E E G+ + K+ +S ++ +
Sbjct: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ 2534
Query: 1021 TKLEKEIDEIRSK---LSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+L ++ ++ + + + E N L+ +I L+ NA L+ +V + YK LE
Sbjct: 2535 EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE 2594
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
NE + E++ A+ +L ++
Sbjct: 2595 NELELTKMDKMSFVEKVNKMTAKETELQREM 2625
Score = 82.6 bits (195), Expect = 1e-14
Identities = 178/923 (19%), Positives = 379/923 (41%), Gaps = 93/923 (10%)
Query: 648 NNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP 707
N LR + + +L +KM K + + + + + + A ++ E +
Sbjct: 1961 NQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLS 2020
Query: 708 AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA----GSNTTA 763
+++ LL+ + T L+ K++ LE+D +AL EL ++I+ + K S +
Sbjct: 2021 SDVSELLK----DKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ 2076
Query: 764 RRSLTTNSNKL----AEERVKVLEDE----IDEVRKKLIEKERDCERLHAELSLAQKKPK 815
R ++ KL A E V + E + ++++ + R E+L + +KK
Sbjct: 2077 ARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL 2136
Query: 816 TLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS--LEADNEKLQTENKKLQLLKN 873
+ + L +++N LK +++ +E+E + + L+A+N K + E K Q+ +
Sbjct: 2137 HI--AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM 2194
Query: 874 AKSLRSDKALDLNTKKTTQ--LENELKEALAKIKELEMICQ------DEKSEKKVRFTEA 925
A+SL+ + LDL T ++ + L +++E ++ EL+ + +EK + +++ E
Sbjct: 2195 ARSLKVFE-LDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS-LKDDAQ-----KSFKPRIP-- 977
+K + L+++ + +L ++++ Q + + R+
Sbjct: 2254 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2313
Query: 978 -KKPTDLTTKLQ--------LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKL 1023
KK + +L+ LK VE+LE E+ + + ++ G+ T K K+
Sbjct: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
E +R L + +EK L E+ K ++ ++LE F N + E E +
Sbjct: 2374 EGMTQSLRG-LELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQM 2432
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
+ T E ++ + ++N+ A L N +
Sbjct: 2433 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 1144 XQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXX 1203
+NY + N L++EV D +K+ R++ Q+ ++ V+
Sbjct: 2493 K--NNYIVLQSSVNGLIQEVEDGKQKL-------EKKDEEISRLKNQIQDQEQLVSKLS- 2542
Query: 1204 XXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKIT 1263
Q + ++EL + EL+ + +SK +L+ + L++ Y+N
Sbjct: 2543 -------QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN 2595
Query: 1264 SLESTIAAKDVHIKQLEDALRQTT---NDKYDEATSPVEM-VEMRXXXXXXXXXXXXXQD 1319
LE T K ++++ + T + ++ A E+ E+ +
Sbjct: 2596 ELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE 2655
Query: 1320 ELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE 1379
E+ ++K +L++ E+S K + + D + E + +++A
Sbjct: 2656 EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEK-KHQALL 2714
Query: 1380 LDTDLQSERK-KLDRMRIAHDKD-VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
LDT+ Q E + + R ++ ++ + ++ E+ LK + L + A + + ELK+
Sbjct: 2715 LDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2774
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYEL-------LEEEHVVTKARLT----VEKEQAQGE 1486
+ +K + K E E GK +L LEEE + + L+ +++Q G
Sbjct: 2775 MDNLKYVNQL----KKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGT 2830
Query: 1487 LLHVQ-KELSTALGEIK-TLQEK 1507
++ + EL+T + E+K TL+EK
Sbjct: 2831 VMDTKVDELTTEIKELKETLEEK 2853
Score = 81.8 bits (193), Expect = 2e-14
Identities = 156/813 (19%), Positives = 333/813 (40%), Gaps = 57/813 (7%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIEQLRA 372
+EV + + + L++ +L +K HL +K++ +E + + T+ E Q Q+ + +
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 373 KLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR 432
L+ + + E++ K + + F A SS + E+ Q +
Sbjct: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEF----ALRLSSTQEEVHQLRRGIE 2122
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV----ARSTEV 488
L +++ E+K + ++ E E++ + + ++RE ++ E QE+ A +++
Sbjct: 2123 KLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKA 2182
Query: 489 ALR-LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
+ L+ ++ E L+ + + E +++ + G + +LL + LE
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTL-RSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE 2241
Query: 548 R----EADLREQLRNAEEETAN-CKQVNPPTFL---DKQVM--TDNIVTCDIHESETVTN 597
E ++E+ + A E N K++N D+++M T+ + I E + N
Sbjct: 2242 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 2301
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN-----HMAANNLRK 652
SI+ + E + L + + +E++ H DL + N +A N
Sbjct: 2302 SIE-------KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH 2354
Query: 653 TAARVEEDN---ESLLLQLKKMATKARSRKLS-PTPPANKLSIETANDNDEKETDEADPA 708
A E E+L +++ M R +L T + K ++ +++ E +
Sbjct: 2355 AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEII 2414
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
L E+E ++ K E+ E L+ Q+KEL +++++ ++L+
Sbjct: 2415 NSSFENILQEKEQEKVQMK-EKSSTAMEMLQTQLKELNERVAALHNDQEACK-AKEQNLS 2472
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA-QKKPKTLIKSRSLDASD 827
+ L E+ ++L+ +DE + I + L E+ QK K + L
Sbjct: 2473 SQVECLELEKAQLLQG-LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 2531
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
Q L +L +E E + K Q+LE N ++ E +K+Q+L++ + D L++
Sbjct: 2532 QDQEQLVSKLSQVEGEHQLW--KEQNLELRNLTVELE-QKIQVLQSKNASLQD-TLEVLQ 2587
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
LENEL+ L K+ ++ + ++ ++ + TE ++ + +
Sbjct: 2588 SSYKNLENELE--LTKMDKMSFV--EKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643
Query: 948 XXXXXXXXXXQATLKSLKDDAQK-SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVV 1006
+KS KD ++ + + KK D K Q++K + E EI E +
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE-EIAEYQLR 2702
Query: 1007 MKNAGLSGKEMTAKT--KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ A + + T + E EI R KL+ + +++K + + +++N L+
Sbjct: 2703 LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2762
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNR 1097
+ + K + +N NQ K E + +
Sbjct: 2763 TTQIL-EELKKTKMDNLKYVNQLKKENERAQGK 2794
Score = 79.8 bits (188), Expect = 9e-14
Identities = 174/840 (20%), Positives = 353/840 (42%), Gaps = 103/840 (12%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAKLLAAET 379
+L+ K+NEL + E K K +E++ +LE + + + + + R +L+
Sbjct: 289 ELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKL 438
++ + ++++L+ L + N S R LEQ IK + +L
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQN--------AESARCSLEQKIKEKEKEFQEEL 400
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ +R L+QE + + +L + + Q +N L+ E+ + T V +L+ L E
Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQ-----ELQQAKNMHNVLQAELDKLTSVKQQLENNLEE 455
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
K + + + ++ + L R S E+ + L+ E++A ++ +
Sbjct: 456 FKQKLCRAEQAF------QASQIKENELRR--SMEEMKKENNLLKSHSEQKA---REVCH 504
Query: 559 AEEETANCKQ-VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E E N KQ +N +++ N ET+ +Q K I+ + EK
Sbjct: 505 LEAELKNIKQCLNQSQNFAEEMKAKNT------SQETMLRDLQEK-INQQENSLTLEKLK 557
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL--LQLKKMATK- 674
++K + +Q DL L H L ++ E+++++LL L+LKK +
Sbjct: 558 LAVADLEKQRDCSQ---DL--LKKREH-HIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Query: 675 -ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQ 733
+ L + + T ++ EKE ++ ++ L+ + ++ +V LE
Sbjct: 612 LKEEKTLFSCWKSENEKLLTQMES-EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
Query: 734 DKEALKKQVKEL------------TSKIS--SVTKTSAGSNTTARRSLTTNSNKLAE--E 777
D+E L +++ L T K++ + + + S+ ++ + K ++
Sbjct: 671 DRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTG 730
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAEL----SLAQKKPKTLIKS----RSLDASDQQ 829
+V+ LE ++ + ++++K+R + LHAE L + K +L+ + RSL A DQQ
Sbjct: 731 QVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ 790
Query: 830 NVDLKRQLQVIEQEASVLRAKTQ-SLEADNEK-----LQTENKKLQL-LKNAKSLRSDKA 882
+I ++ S+ +++ LEAD LQ L+ L++ K + SD
Sbjct: 791 PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD-- 848
Query: 883 LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXX 942
L ++ Q++ E++E L K +++ E S++ + E T + +
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALEN 908
Query: 943 XXXXXXXXXXXXXXXQATLKSLK------DDAQKSFK---PRIPKKPTDLTTKLQL-KKM 992
QA ++ LK +D+ K + + + ++++ + L K+
Sbjct: 909 KEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKRE 968
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE---KEIDEIRSKLSKNDSEFTNEKNRLQ 1049
+E+L E G + + NA L+ ++M K E IDE +S+ ++ EK L
Sbjct: 969 IEELTQENGTLKEI--NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL- 1025
Query: 1050 TEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS---NQCKTLTEEMKNREAQINKLSA 1106
+ + ++ E + KYKA + +NS L N+C +L E KN Q+ + A
Sbjct: 1026 --LQRCEETGNAYED----LSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
Score = 73.7 bits (173), Expect = 6e-12
Identities = 137/706 (19%), Positives = 284/706 (40%), Gaps = 47/706 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE + + + LK +V+ L + + E+ + ++L A A T E +
Sbjct: 2138 IAEKLKERERENDSLKDKVENLERELQMSEENQELVILD--AENSKAEVETLKTQIEEMA 2195
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIE---SELETRPST------EAQTRQIEQLRA 372
KV EL LR EK++LT++I+E + SEL+ S+ E + +I+
Sbjct: 2196 RSLKVFELDLVT--LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253
Query: 373 KLLAAETLCEELMDENEDMKKELRD---LXXXXXXMQDNFREDQA--DEYSSLRRELEQT 427
A E L +L + NE + D + + E+ + LR LE
Sbjct: 2254 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2313
Query: 428 IKNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQREN---RIKELEQEV 482
K + +LK++E AD L+ E E E ++ ++ EN ++ L+ ++
Sbjct: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP-ETVKVSRSSLTRGGSQEDPAQLLRD 541
T+ L+ ++ S+ L K + +++ SS +++ ++
Sbjct: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2433
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---S 598
+ S E L+ QL+ E A +Q ++ + ++ +++ + +
Sbjct: 2434 EKSSTAMEM-LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEE-----TQFHFDLPYLSIFNHMAANNLRKT 653
N ++ +S ++ + ++K EE Q +S + + +
Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2552
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+E N ++ L+ K ++++ L T ++++ N E E + +M +
Sbjct: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEV----LQSSYKNLENELELTKMDKMSFV 2608
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
++N+ A K EL+++ + ++ EL ++S AG + ++ ++
Sbjct: 2609 EKVNKMTA-----KETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663
Query: 774 LAEERVK--VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
L E ++ L+ +D + K +EKE AE L + + ++ LD + Q V
Sbjct: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL-NTKKT 890
+++ + + + L +Q LE D K E L + L K + N K
Sbjct: 2724 EIQTYREKLTSKEECL--SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYV 2781
Query: 891 TQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
QL+ E + A K+K L C+ + EK++ E ++ + K K
Sbjct: 2782 NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK 2827
Score = 71.3 bits (167), Expect = 3e-11
Identities = 195/1097 (17%), Positives = 402/1097 (36%), Gaps = 60/1097 (5%)
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
++ D ++L ++ E L +E+ ++ E+L ++KEL SK+ + + +
Sbjct: 1765 NQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLH-LQEVQLMTKIE 1823
Query: 763 ARRSLTTNSNKLAEERVKVLE--DEIDEVRKKLIEKERDCERLHAELSL-AQKKPKTLIK 819
A L +L +E + E + ++L+++ E L+++L + A K + I
Sbjct: 1824 ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIG 1883
Query: 820 SRSLDASD---QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
+D ++ +D++ +L I E + + + LEAD E +QTE KL L K+ ++
Sbjct: 1884 DNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE--KLCLEKDNEN 1941
Query: 877 LRS-----DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
+ ++ L + T + QL EL K L+ + EK ++K + E +++
Sbjct: 1942 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL--SEKMKEKTQ--ELESHQSE 1997
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS---LKDDAQKSFKPRIPKKPTDLTTKLQ 988
L Q LK L++ Q K T + Q
Sbjct: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2057
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKE-MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+ ++ ++ E + E + S E + LE + E + + + S E ++
Sbjct: 2058 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE-KGEFALRLSSTQEEVHQ 2116
Query: 1048 LQTEIAKLKDVNAKLEGDKDV-FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
L+ I KL+ V + + K + A K K E EN +L ++ + L E++ E +
Sbjct: 2117 LRRGIEKLR-VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVIL 2175
Query: 1107 DLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDK 1166
D +N+ + T+ + +N TK Q+K L E+
Sbjct: 2176 DAENSKAEVETLK---TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKL 2232
Query: 1167 TKKIGDXXXXXXXXXXXCKRIEK-QLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-- 1223
K K + ++++ ++ T + L
Sbjct: 2233 LSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPP 2292
Query: 1224 IE----LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
IE L + ++L+AR E K + + ++++ + + +E+ ++
Sbjct: 2293 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2352
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
E A + N K + T ++ M + E N +L+K + S +
Sbjct: 2353 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
+ + ++ L + E + E L ++++
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLS 2472
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS------LALEKA 1453
V+ + E A L L + N + L QE E+ +KLE L +
Sbjct: 2473 SQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ 2532
Query: 1454 EYEELTGKYELLEEEHVVTKAR------LTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
+ E+L K +E EH + K + LTVE EQ L L L +++ +
Sbjct: 2533 DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2592
Query: 1508 LGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
L E +K E N + + + L E+ + + + + R A + +
Sbjct: 2593 LENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQL 2652
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
+LE + + + + + ++EK +A
Sbjct: 2653 LLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQA 2712
Query: 1625 EITDTKTRYEGQMNTMRDELKSLHN-------QVSRFRRERDNYKQMLEAAQKSMAEIKN 1677
+ DT +YE ++ T R++L S ++ + ++ L+A + + E+K
Sbjct: 2713 LLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2772
Query: 1678 GDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA- 1736
+ N + + E + K+ LL + LE+E + S+L +K+
Sbjct: 2773 TKMDNLKYVNQLKK-ENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV 2831
Query: 1737 -EVRLAEMQSRLNEYEE 1752
+ ++ E+ + + E +E
Sbjct: 2832 MDTKVDELTTEIKELKE 2848
Score = 70.9 bits (166), Expect = 4e-11
Identities = 183/904 (20%), Positives = 358/904 (39%), Gaps = 80/904 (8%)
Query: 289 RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ-KVNELTTHNEDLRDE----KKHL 343
+ E +K + ++L N K R+ + + Q K NEL E+++ E K H
Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
Query: 344 TQKIREI---ESELETRPSTEAQTRQI-EQLRAKLLAAETLCEELMD-----EN----ED 390
QK RE+ E+EL+ Q++ E+++AK + ET+ +L + EN E
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
+K + DL QD ++ + L +L +T K + L L+ +++ ++L++
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKRE-HHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
Query: 451 EK-------AEHEKKLLEIVGGPDGMQRE-NRIKE-LEQEVARSTEVALRLQRELAEANS 501
EK +E+EK L ++ + +Q + N ++ L+ + +S E R+ R L
Sbjct: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERV-RTLEMDRE 673
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
+ +L V ++V+V L Q+ + Q +E QL E
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 562 ETANCKQVNPPTFLDK-----------QVMTD-------NIVTCDIHESETVTNSIQNKM 603
+ + Q+ +DK + + D ++VT + H+ + Q M
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 604 IHA--------ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN-LRKTA 654
H+ S PS + + K + Q D S+ + N+ L+K
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLL 713
+ + + L K +S + +KL +T A+ N ET A + K L
Sbjct: 854 EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELT--SKISSVTKTSAGS----NTTARRSL 767
LN++ T + +++EL++ L+ +KEL S+ S+ K S N L
Sbjct: 914 QLLNDKVETE-QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL 972
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKK--LIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
T + L E + +++++ ++K + E+ +ELS K+ K ++ R +
Sbjct: 973 TQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEET 1032
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEA--DNEKLQTENKKLQLLKNAKSLRSDKAL 883
+ DL ++ + +++ S L + +N K + E K K + + A
Sbjct: 1033 GNAYE-DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAF 1091
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ LE E + + E+ + KSE K+E TLK +Q
Sbjct: 1092 AEERNQNLMLELETVQQALR-SEMTDNQNNSKSE-----AGGLKQEIMTLKEEQNKMQKE 1145
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEI 1000
T ++ + + + ++ ++ K Q+ V+++ +
Sbjct: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205
Query: 1001 GEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+V A L KE+ + ++ EKE + + + D E +N ++ EI+ LKD
Sbjct: 1206 YNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCE 1265
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD-LKNATSLQTTM 1118
E ++ +N+N++L +T ++ E L A+ + T L +
Sbjct: 1266 IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR 1325
Query: 1119 SDCM 1122
S+C+
Sbjct: 1326 SECI 1329
Score = 59.3 bits (137), Expect = 1e-07
Identities = 141/786 (17%), Positives = 303/786 (38%), Gaps = 37/786 (4%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELET-RPSTEAQTRQIEQLRAKLLAAETLCE 382
QK+ EL + L+ EK+ ++ +E+ L+ + E + + L+ + +CE
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 383 ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTE 442
L + + EL+ Q NF+E Q + +LEQ +K C+ + ++
Sbjct: 78 SLEKTKQKISHELQ-----VKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAA 132
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSK 502
+ AD + +K+ P ++ ++L+++ + E RL+ E+ +K
Sbjct: 133 QSAD-VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK 191
Query: 503 FTGSNPSLMKVPQPETVKVSRSSLTRGGSQE-DPAQLLRDLQDSLEREADLREQLRNAEE 561
+ + + SS QE P+ L + Q + R D + E+
Sbjct: 192 KASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR-DFSASYFSGEQ 250
Query: 562 ETANCKQVNPPTFLD-KQVMTDNIVTCDIHESETVTN-SIQNKMIHAASTPSSKEKSDSP 619
E + D DN + + + N ++NK+ EK
Sbjct: 251 EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKG 310
Query: 620 PLSIDKTTEETQFHFDLPYLSIF-NHMAANNLRKTAARVEEDNESLLLQLKKMATKARSR 678
++ +E Q + + + N R R + K A + + +
Sbjct: 311 QVN---KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQ--ASTKYTALEQKLK 365
Query: 679 KLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEAL 738
KL+ + + E+A + E++ E E + EL+ Q+ + + +E Q K L
Sbjct: 366 KLTEDLSCQRQNAESARCSLEQKIKE---KEKEFQEELSRQQRS-FQTLDQECIQMKARL 421
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
+++++ + +V + T+ ++ L N + ++ + E + K E R
Sbjct: 422 TQELQQ-AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRA-EQAFQASQIKENELRR 479
Query: 799 DCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADN 858
E + E +L + + K+R + + + ++K+ L + A ++AK S E
Sbjct: 480 SMEEMKKENNLLKSHSEQ--KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
Query: 859 EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE-LKEALAKIKEL-EMICQDEKS 916
LQ +K+ +N+ +L K + +K + LK+ I++L + + + EK
Sbjct: 538 RDLQ---EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE 594
Query: 917 EKK-VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
K + E KKE + LK ++ + L+S + + K +
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLS 1035
K L+ E+L EI ++ V L K + +T+ + E++ K
Sbjct: 655 QIKSHEYNERVRTLEMDRENLSVEIRNLHNV-----LDSKSVEVETQ-KLAYMELQQKAE 708
Query: 1036 KNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+D + E + + ++L LE + +N+ + +L + ++L + +K
Sbjct: 709 FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
Query: 1096 NREAQI 1101
+++A +
Sbjct: 769 SKDASL 774
Score = 49.6 bits (113), Expect = 1e-04
Identities = 87/439 (19%), Positives = 188/439 (42%), Gaps = 53/439 (12%)
Query: 270 QDQIEGLKQEVDI----LRKRCERVEKEKSDI-----LLRRLANIDTANKYTTGRSSEV- 319
Q + GL QEV+ L K+ E + + K+ I L+ +L+ ++ ++ ++ E+
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559
Query: 320 ---LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
++L+QK+ L + N L+D + L + +E+ELE T+ + K+ A
Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELEL---TKMDKMSFVEKVNKMTA 2616
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
ET EL E +M ++ +L ++ A E L E++ + + L+
Sbjct: 2617 KET---ELQREMHEMAQKTAELQEELSGEKNRL----AGELQLLLEEIKSSKDQLKELTL 2669
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE-VARSTEVALRLQRE 495
+ + ++ D + +++ E E K+ E + + + R+ E E++ A + + + E
Sbjct: 2670 ENSELKKSLDCMHKDQVEKEGKVREEIA-----EYQLRLHEAEKKHQALLLDTNKQYEVE 2724
Query: 496 LAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQ----DSLEREA 550
+ K T L + + +K S+ L S + Q+L +L+ D+L+
Sbjct: 2725 IQTYREKLTSKEECLSSQKLEIDLLKSSKEEL--NNSLKATTQILEELKKTKMDNLKYVN 2782
Query: 551 DLREQLRNAEEE----TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHA 606
L+++ A+ + +CKQ+ +K+++ + + + T ++ + +
Sbjct: 2783 QLKKENERAQGKMKLLIKSCKQLEE----EKEILQKELSQLQAAQEKQKTGTVMDTKVDE 2838
Query: 607 ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
+T + K ++++ T+E + D Y S+ ++ L K +E L
Sbjct: 2839 LTTEIKELKE-----TLEEKTKEADEYLD-KYCSLL--ISHEKLEKAKEMLETQVAHLCS 2890
Query: 667 QLKKMATKARSRKLSPTPP 685
Q K ++ S L P P
Sbjct: 2891 QQSKQDSRG-SPLLGPVVP 2908
Score = 49.2 bits (112), Expect = 1e-04
Identities = 128/666 (19%), Positives = 260/666 (39%), Gaps = 44/666 (6%)
Query: 648 NNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPT--PPANKLSIETANDNDEKETDEA 705
+ L+K + + +SL L+K K + K T N+ +E ++ + +
Sbjct: 28 DKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKIS 87
Query: 706 DPAEMKLLLELNEQEATVL--RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
++K ++N QE + ++++E+LEQ+ + K ++ E + + + S T
Sbjct: 88 HELQVKES-QVNFQEGQLNSGKKQIEKLEQELKRCKSEL-ERSQQAAQSADVSLNPCNTP 145
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER---DCERLHAELSLAQKKPKTLIKS 820
++ TT ED ++ K++ E++R + + L A+ + +Q P+ +
Sbjct: 146 QKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKA-SQTLPQATMNH 204
Query: 821 RSL---DASDQ----QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK- 872
R + AS Q L Q + R + S + +++ LQ+ K
Sbjct: 205 RDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKR 264
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+A S D + + QL+ + +E KI ELE+ Q + E K + + + +
Sbjct: 265 DANSSFFDNSSSPHL--LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQL 322
Query: 933 LKSK-QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKK 991
K+K + Q S K A + ++ K DL+ + Q +
Sbjct: 323 EKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA---LEQKLKKLTEDLSCQRQNAE 379
Query: 992 MVE-DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
LE +I E + LS ++ + +T L++E +++++L++ + N N LQ
Sbjct: 380 SARCSLEQKIKEKEKEFQEE-LSRQQRSFQT-LDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALEN--ENSNL-SNQCKTLTEEMKNREAQINKLSAD 1107
E+ KL V +LE + + F K E + S + N+ + EEMK + S
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497
Query: 1108 -LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQV-DNYTKIDQDKNKLLKEVGD 1165
+ L+ + + + D KI+Q +N L E
Sbjct: 498 KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE--- 554
Query: 1166 KTK-KIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI 1224
K K + D K+ E + D+++ +A++ A ++
Sbjct: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS-----KTEKESKALLSALELKKKEY 609
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR 1284
E E+ L + + K +T +M K + ++KI LE+ + + + + + +R
Sbjct: 610 EELKEEKTLFSCWKSENEKLLT---QMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666
Query: 1285 QTTNDK 1290
D+
Sbjct: 667 TLEMDR 672
Score = 44.4 bits (100), Expect = 0.004
Identities = 53/261 (20%), Positives = 112/261 (42%), Gaps = 19/261 (7%)
Query: 154 QTQLAITKND--SLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYK-- 209
+ +L +TK D S E+V KM +T+ E +K E + +++ +
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
Query: 210 -DERSSTKDDVNFLM----QVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXX----XX 260
+E S+KD + L ++K S + + + G
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2713
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
L+D+N K+Y+ +I+ ++++ ++ C +K + D+L ++ + K TT E+
Sbjct: 2714 LLDTN-KQYEVEIQTYREKLTS-KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK 2771
Query: 321 KLQQK----VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
K + VN+L NE + + K L + +++E E E +Q + ++ +
Sbjct: 2772 KTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV 2831
Query: 377 AETLCEELMDENEDMKKELRD 397
+T +EL E +++K+ L +
Sbjct: 2832 MDTKVDELTTEIKELKETLEE 2852
Score = 44.0 bits (99), Expect = 0.006
Identities = 170/870 (19%), Positives = 353/870 (40%), Gaps = 84/870 (9%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
++ + V + +E KQ L+K+CE + + K +I + + S +
Sbjct: 827 ILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS 886
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
KLQ+ + + H + + L K +E++ L + TE Q E ++ L ++L
Sbjct: 887 KLQE---DTSAHQNVVAETLSALENKEKELQL-LNDKVETE-QAEIQELKKSNHLLEDSL 941
Query: 381 CE-ELMDENEDM-KKELRDLXXXXXXMQDNFREDQA---DEYSSLRRELEQTIKNCRVLS 435
E +L+ E + KKE+ + + ++ + +SL +E I+ +
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
+ + E+ +L + + + LL+ + N ++L Q+ + E +L+
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRC-----EETGNAYEDLSQKYKAAQEKNSKLECL 1056
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ-LLRDLQDSLER-EADLR 553
L E S L ++ + K + LT+ E+ Q L+ +L+ + +++
Sbjct: 1057 LNECTSLCENRKNELEQLKE-AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
+ N++ E KQ T ++Q V + E+E + ++ K H S+
Sbjct: 1116 DNQNNSKSEAGGLKQ-EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK--HECQNLESE 1172
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN-ESLLLQLKKMA 672
+S ++ +E Q +F P + + V+E + +S QL ++
Sbjct: 1173 PIRNSVK---ERESERNQCNFK-PQMDL--------------EVKEISLDSYNAQLVQLE 1214
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE 732
R+++L + E E +T D E L ++ QE + L K E++
Sbjct: 1215 AMLRNKELK----LQESEKEKECLQHELQTIRGD-LETSNLQDMQSQEISGL--KDCEID 1267
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERV-KVLEDEIDEVR 790
+++ + + TS+ N + SL T NKL E E++ ++L+ E E+
Sbjct: 1268 AEEKYISGPHELSTSQ---------NDNAHLQCSLQTTMNKLNELEKICEILQAEKYELV 1318
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSL-DASDQQNVDLKRQL---QVIEQEASV 846
+L + +C + A +A++ K L + + L D S + +L + + EQ
Sbjct: 1319 TELNDSRSEC--ITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQ 1376
Query: 847 LRAKTQSLEADN--EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
L+ N E L +K++Q+ + L+ +K L L ++ L ++ + +K+
Sbjct: 1377 HPVSLAPLDESNSYEHLTLSDKEVQM--HFAELQ-EKFLSLQSEHKI-LHDQHCQMSSKM 1432
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
EL+ K+E V T + D +K Q ++L SL
Sbjct: 1433 SELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQ--LGLEEGLVPSLSSSCVPDSSSLSSL 1490
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYV-VMKNAGLSGKEM-TAKTK 1022
D SF + ++ D++ L+ V +C + E++ ++ L+ KE +A K
Sbjct: 1491 GD---SSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAK 1547
Query: 1023 LEKEIDEI----RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALEN 1078
+E++ + R L K + + ++ EI +L+ + + + D +Y +
Sbjct: 1548 GVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYL---S 1604
Query: 1079 ENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
EN + ++T EM+++ A K + L
Sbjct: 1605 ENEQWQQKLTSVTLEMESKLAAEKKQTEQL 1634
Score = 39.1 bits (87), Expect = 0.16
Identities = 37/167 (22%), Positives = 72/167 (43%), Gaps = 12/167 (7%)
Query: 1617 QSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIK 1676
Q+ + ++ E+ + + + N ++ + +V E N KQ L +Q E+K
Sbjct: 468 QASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK 527
Query: 1677 NGDKSARIHRNSI--------SSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
+ S + +S E+ + VA LE+Q C +D L + +LN +
Sbjct: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
Query: 1729 LVSEKSSAEVRLAEMQSRLNEY----EEERLLSSGRARVAGLATRME 1771
L + ++ L+ ++ + EY EE+ L S ++ L T+ME
Sbjct: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME 634
Score = 39.1 bits (87), Expect = 0.16
Identities = 85/406 (20%), Positives = 168/406 (41%), Gaps = 48/406 (11%)
Query: 1376 KAKELDTDLQSERKK-LDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK 1434
K KE +L+S + + L +++A + +VK K L TL + L ++ T L
Sbjct: 1983 KMKEKTQELESHQSECLHCIQVA-EAEVKEKTELLQTLSSDVSELLKDK-------THL- 2033
Query: 1435 QEYEETVKKLEHSLALEKAEYE----ELTGKYELLEEEHVVTKARLTVEKEQAQGELLHV 1490
QE ++++K +L+L K E E +L + ELL +E +ARL+ ++ E L+V
Sbjct: 2034 QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLS----ESDYEKLNV 2089
Query: 1491 QKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD 1550
K L AL E + + ++ E +++ I L+ R+ E ++ + +L
Sbjct: 2090 SKALEAALVE----KGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD--EKKQLHIAEKLK 2143
Query: 1551 QRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXX 1610
+RERE + D+ + LE + + + Q
Sbjct: 2144 ERERENDSLKDKVENLER-----------------ELQMSEENQELVILDAENSKAEVET 2186
Query: 1611 XXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
IE+ ++ K D T + + +++ Q+S + ++K +LE ++
Sbjct: 2187 LKTQIEEMARSLKVFELDLVT-LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ 2245
Query: 1671 SMAEIKNGDKSA-RIHRNSISSTDE--EEYRNKVALLEQQVACLEDELCESRLLASKLNT 1727
+ +IK K+A + +N + +E +++ L+ + E L + +
Sbjct: 2246 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305
Query: 1728 ELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA 1773
++ + +L +Q +L E E L G RV L +E+A
Sbjct: 2306 LRARLEADEKKQLCVLQ-QLKESEHHADLLKG--RVENLERELEIA 2348
Score = 38.3 bits (85), Expect = 0.28
Identities = 61/305 (20%), Positives = 126/305 (41%), Gaps = 29/305 (9%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYE---NKITSLESTIAAKDVHIKQL-- 1279
+LT + ++L+ + ++ + + +DL A+YE + + S ++++ + H + L
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786
Query: 1280 ---EDALRQT-TNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
+ A+ + N ++ + P E E R Q+ +++ + LE + +
Sbjct: 787 FDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMN 846
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD---------LQS 1386
S + + +L ++E +S +K +E DT L +
Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE-DTSAHQNVVAETLSA 905
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
K +++ +DK V+ + AE+ LK +LE + K + L + K++
Sbjct: 906 LENKEKELQLLNDK-VETEQAEIQELKKSNHLLEDS----LKELQLLSETLSLEKKEMSS 960
Query: 1447 SLALEKAEYEELTGKYELLEEEHV---VTKARLTVEKEQAQGELLHVQKELSTALGEIKT 1503
++L K E EELT + L+E + K L + E + +K +S + K
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYK- 1019
Query: 1504 LQEKL 1508
QEKL
Sbjct: 1020 -QEKL 1023
Score = 37.5 bits (83), Expect = 0.48
Identities = 65/342 (19%), Positives = 134/342 (39%), Gaps = 14/342 (4%)
Query: 1228 SEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTT 1287
S+ ++L+ ++ K + LEAE++ L+A ++ T ++T+ +D+ Q ++
Sbjct: 162 SKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQ-TLPQATMNHRDIARHQASSSVFSWQ 220
Query: 1288 NDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS-----AAKLEM 1342
+K S + + + +++ K +A SS ++ +
Sbjct: 221 QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280
Query: 1343 AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK-- 1400
QLK+ +L N NK +EL L+ + +L +K
Sbjct: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCR 340
Query: 1401 -DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
++ A+ K LEQ + ++ +Q E LE + ++ E++E
Sbjct: 341 DELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEEL 400
Query: 1460 GK----YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT-ESAA 1514
+ ++ L++E + KARLT E +QA+ +Q EL + L+ L +
Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL 460
Query: 1515 WNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQREREL 1556
E+ + I + R + E L + +Q+ RE+
Sbjct: 461 CRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREV 502
Score = 36.3 bits (80), Expect = 1.1
Identities = 59/315 (18%), Positives = 117/315 (37%), Gaps = 19/315 (6%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
L ++ ++ E Q + + F TL+ E +KA ++ ++ + +L
Sbjct: 385 LEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTS 444
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL- 1340
+Q N+ +E + E E + L K+ +E A ++
Sbjct: 445 VKQQLENN-LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
Query: 1341 ----EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
E+ +K L + +N + K + + L E+ KL +
Sbjct: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
Query: 1397 AHDKD-----VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALE 1451
+D +K ++ + L KL E+ S A + K+EYEE +K+ + +
Sbjct: 564 EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE-LKEEKTLFSCW 622
Query: 1452 KAEYEELTGKYELLEE------EHVVTKARLTVEKEQAQGELLH-VQKELSTALGEIKTL 1504
K+E E+L + E +E H+ T + K E + ++ + EI+ L
Sbjct: 623 KSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNL 682
Query: 1505 QEKLGTESAAWNTEK 1519
L ++S T+K
Sbjct: 683 HNVLDSKSVEVETQK 697
>AL445305-6|CAH73032.1| 3114|Homo sapiens centromere protein F,
350/400ka (mitosin) protein.
Length = 3114
Score = 83.4 bits (197), Expect = 7e-15
Identities = 182/870 (20%), Positives = 359/870 (41%), Gaps = 62/870 (7%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSE-VLKL---Q 323
E ++QI L +E ++L K E ++ S+ +L N+ A + E L+L Q
Sbjct: 2053 ELENQIAQLNKEKELLVKESESLQARLSESDYEKL-NVSKALEAALVEKGEFALRLSSTQ 2111
Query: 324 QKVNELTTHNEDLR-----DEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
++V++L E LR DEKK H+ +K++E E E ++ ++E L +L
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE------NDSLKDKVENLERELQM 2165
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
+E E ++ + E+ K E+ L M + + + D +LR E E K +
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD-LVTLRSEKENLTKQIQEKQG 2224
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR--ENRIKELEQEVAR---STEVALR 491
+L + ++ + E E+ ++I +N++KEL + VA E+
Sbjct: 2225 QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284
Query: 492 LQREL---AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
++ L E + S L + + K L + E A LL+ ++LER
Sbjct: 2285 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKK-QLCVLQQLKESEHHADLLKGRVENLER 2343
Query: 549 EADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAA 607
E ++ R +A E N K + MT ++ ++ + T+ + +N
Sbjct: 2344 ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL-DVVTIRSEKEN-----L 2397
Query: 608 STPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL-L 666
+ KE+ L I ++ E ++ + +++E NE + L
Sbjct: 2398 TNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAAL 2457
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE--QEATVL 724
+ A KA+ + LS L +E A + DEA + L +N QE
Sbjct: 2458 HNDQEACKAKEQNLSSQVEC--LELEKAQLL--QGLDEAKNNYIVLQSSVNGLIQEVEDG 2513
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT-NSNKLAEERVKVLE 783
++K+E+ +++ LK Q+++ +S +++ ++L N E++++VL+
Sbjct: 2514 KQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ ++ L + + L EL L + + ++ ++ + +L+R++ + Q+
Sbjct: 2574 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK--VNKMTAKETELQREMHEMAQK 2631
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ L+ + L + +L E LQLL D+ +L T + ++L+ L
Sbjct: 2632 TAELQ---EELSGEKNRLAGE---LQLLLEEIKSSKDQLKEL-TLENSELKKSLDCMHKD 2684
Query: 904 IKELEMICQDEKSEKKVRFTEATKKET----DTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
E E ++E +E ++R EA KK DT K + +
Sbjct: 2685 QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKL 2744
Query: 960 T---LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
LKS K++ S K TK+ K V L+ E MK S K+
Sbjct: 2745 EIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ 2804
Query: 1017 MTAKTK-LEKEIDEIRS--KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ + + L+KE+ ++++ + K + + + L TEI +LK+ + + D + +KY
Sbjct: 2805 LEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKY 2864
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINK 1103
+L + L + L ++ + +Q +K
Sbjct: 2865 CSLLISHEKLEKAKEMLETQVAHLCSQQSK 2894
Score = 83.0 bits (196), Expect = 1e-14
Identities = 170/871 (19%), Positives = 348/871 (39%), Gaps = 85/871 (9%)
Query: 314 GRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQ-KIREIESELETRPSTEAQTRQIE-QLR 371
G ++ LQ +V E T NE+LR H+ + + R++ES L +++ E QL
Sbjct: 1764 GNQEDIHNLQLRVKE--TSNENLR--LLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLM 1819
Query: 372 AKLLAA---ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ---AD-EYSSLRREL 424
K+ A E + EL EN D+ ++L + + +D E + +
Sbjct: 1820 TKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSR 1879
Query: 425 EQTIKNCRVLSFKLKK----TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQ 480
E N ++ K+ E + ++ EKA E + L + + +Q E E +
Sbjct: 1880 EDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN 1939
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
E +V + L+ EL+ S+ L + + T S + +QE +
Sbjct: 1940 E--NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSE 1997
Query: 541 DLQDSLEREADLREQLRNAEEETANCKQV--------NPPTFLDKQVMTDNIVTCDIHES 592
L EA+++E+ + +++ ++ L+K ++ C++
Sbjct: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2057
Query: 593 ETVTNSIQNKMIHAASTPSSK-EKSDSPPLSIDKT-----TEETQFHFDLPYLSIFNHMA 646
N + ++ + + ++ +SD L++ K E+ +F L H
Sbjct: 2058 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQL 2117
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDE-----K 700
+ K R+E D + L +K+ + R N + ++ + +N E
Sbjct: 2118 RRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDA 2177
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK--TSAG 758
E +A+ +K +E + V + L +KE L KQ++E ++S + K +S
Sbjct: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2237
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKL--------------------IEKER 798
S + + ++ V++L++++ E+ + + IE+E
Sbjct: 2238 SLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2297
Query: 799 DC----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ-- 852
E+L A L +KK +++ L S+ LK +++ +E+E + R +
Sbjct: 2298 QLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADLLKGRVENLERELEIARTNQEHA 2355
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ--LENELKEALAKIKELEMI 910
+LEA+N K + E K ++ +SLR + LD+ T ++ + L NEL++ +I ELE+I
Sbjct: 2356 ALEAENSKGEVETLKAKIEGMTQSLRGLE-LDVVTIRSEKENLTNELQKEQERISELEII 2414
Query: 911 CQD------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
EK ++KV+ E + + L+++ + L S
Sbjct: 2415 NSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL--ECEIGEMYVVMKNAGLSG--KEMTAK 1020
+ + + + L+ V L E E G+ + K+ +S ++ +
Sbjct: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ 2534
Query: 1021 TKLEKEIDEIRSK---LSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+L ++ ++ + + + E N L+ +I L+ NA L+ +V + YK LE
Sbjct: 2535 EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE 2594
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
NE + E++ A+ +L ++
Sbjct: 2595 NELELTKMDKMSFVEKVNKMTAKETELQREM 2625
Score = 82.6 bits (195), Expect = 1e-14
Identities = 178/923 (19%), Positives = 379/923 (41%), Gaps = 93/923 (10%)
Query: 648 NNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP 707
N LR + + +L +KM K + + + + + + A ++ E +
Sbjct: 1961 NQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLS 2020
Query: 708 AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA----GSNTTA 763
+++ LL+ + T L+ K++ LE+D +AL EL ++I+ + K S +
Sbjct: 2021 SDVSELLK----DKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ 2076
Query: 764 RRSLTTNSNKL----AEERVKVLEDE----IDEVRKKLIEKERDCERLHAELSLAQKKPK 815
R ++ KL A E V + E + ++++ + R E+L + +KK
Sbjct: 2077 ARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL 2136
Query: 816 TLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS--LEADNEKLQTENKKLQLLKN 873
+ + L +++N LK +++ +E+E + + L+A+N K + E K Q+ +
Sbjct: 2137 HI--AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM 2194
Query: 874 AKSLRSDKALDLNTKKTTQ--LENELKEALAKIKELEMICQ------DEKSEKKVRFTEA 925
A+SL+ + LDL T ++ + L +++E ++ EL+ + +EK + +++ E
Sbjct: 2195 ARSLKVFE-LDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS-LKDDAQ-----KSFKPRIP-- 977
+K + L+++ + +L ++++ Q + + R+
Sbjct: 2254 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2313
Query: 978 -KKPTDLTTKLQ--------LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKL 1023
KK + +L+ LK VE+LE E+ + + ++ G+ T K K+
Sbjct: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
E +R L + +EK L E+ K ++ ++LE F N + E E +
Sbjct: 2374 EGMTQSLRG-LELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQM 2432
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
+ T E ++ + ++N+ A L N +
Sbjct: 2433 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 1144 XQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXX 1203
+NY + N L++EV D +K+ R++ Q+ ++ V+
Sbjct: 2493 K--NNYIVLQSSVNGLIQEVEDGKQKL-------EKKDEEISRLKNQIQDQEQLVSKLS- 2542
Query: 1204 XXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKIT 1263
Q + ++EL + EL+ + +SK +L+ + L++ Y+N
Sbjct: 2543 -------QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN 2595
Query: 1264 SLESTIAAKDVHIKQLEDALRQTT---NDKYDEATSPVEM-VEMRXXXXXXXXXXXXXQD 1319
LE T K ++++ + T + ++ A E+ E+ +
Sbjct: 2596 ELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE 2655
Query: 1320 ELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE 1379
E+ ++K +L++ E+S K + + D + E + +++A
Sbjct: 2656 EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEK-KHQALL 2714
Query: 1380 LDTDLQSERK-KLDRMRIAHDKD-VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
LDT+ Q E + + R ++ ++ + ++ E+ LK + L + A + + ELK+
Sbjct: 2715 LDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2774
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYEL-------LEEEHVVTKARLT----VEKEQAQGE 1486
+ +K + K E E GK +L LEEE + + L+ +++Q G
Sbjct: 2775 MDNLKYVNQL----KKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGT 2830
Query: 1487 LLHVQ-KELSTALGEIK-TLQEK 1507
++ + EL+T + E+K TL+EK
Sbjct: 2831 VMDTKVDELTTEIKELKETLEEK 2853
Score = 81.8 bits (193), Expect = 2e-14
Identities = 156/813 (19%), Positives = 333/813 (40%), Gaps = 57/813 (7%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIEQLRA 372
+EV + + + L++ +L +K HL +K++ +E + + T+ E Q Q+ + +
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 373 KLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR 432
L+ + + E++ K + + F A SS + E+ Q +
Sbjct: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEF----ALRLSSTQEEVHQLRRGIE 2122
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV----ARSTEV 488
L +++ E+K + ++ E E++ + + ++RE ++ E QE+ A +++
Sbjct: 2123 KLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKA 2182
Query: 489 ALR-LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
+ L+ ++ E L+ + + E +++ + G + +LL + LE
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTL-RSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE 2241
Query: 548 R----EADLREQLRNAEEETAN-CKQVNPPTFL---DKQVM--TDNIVTCDIHESETVTN 597
E ++E+ + A E N K++N D+++M T+ + I E + N
Sbjct: 2242 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 2301
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN-----HMAANNLRK 652
SI+ + E + L + + +E++ H DL + N +A N
Sbjct: 2302 SIE-------KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH 2354
Query: 653 TAARVEEDN---ESLLLQLKKMATKARSRKLS-PTPPANKLSIETANDNDEKETDEADPA 708
A E E+L +++ M R +L T + K ++ +++ E +
Sbjct: 2355 AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEII 2414
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
L E+E ++ K E+ E L+ Q+KEL +++++ ++L+
Sbjct: 2415 NSSFENILQEKEQEKVQMK-EKSSTAMEMLQTQLKELNERVAALHNDQEACK-AKEQNLS 2472
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA-QKKPKTLIKSRSLDASD 827
+ L E+ ++L+ +DE + I + L E+ QK K + L
Sbjct: 2473 SQVECLELEKAQLLQG-LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 2531
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
Q L +L +E E + K Q+LE N ++ E +K+Q+L++ + D L++
Sbjct: 2532 QDQEQLVSKLSQVEGEHQLW--KEQNLELRNLTVELE-QKIQVLQSKNASLQD-TLEVLQ 2587
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
LENEL+ L K+ ++ + ++ ++ + TE ++ + +
Sbjct: 2588 SSYKNLENELE--LTKMDKMSFV--EKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643
Query: 948 XXXXXXXXXXQATLKSLKDDAQK-SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVV 1006
+KS KD ++ + + KK D K Q++K + E EI E +
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE-EIAEYQLR 2702
Query: 1007 MKNAGLSGKEMTAKT--KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ A + + T + E EI R KL+ + +++K + + +++N L+
Sbjct: 2703 LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2762
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNR 1097
+ + K + +N NQ K E + +
Sbjct: 2763 TTQIL-EELKKTKMDNLKYVNQLKKENERAQGK 2794
Score = 79.8 bits (188), Expect = 9e-14
Identities = 174/840 (20%), Positives = 353/840 (42%), Gaps = 103/840 (12%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAKLLAAET 379
+L+ K+NEL + E K K +E++ +LE + + + + + R +L+
Sbjct: 289 ELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKL 438
++ + ++++L+ L + N S R LEQ IK + +L
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQN--------AESARCSLEQKIKEKEKEFQEEL 400
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ +R L+QE + + +L + + Q +N L+ E+ + T V +L+ L E
Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQ-----ELQQAKNMHNVLQAELDKLTSVKQQLENNLEE 455
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
K + + + ++ + L R S E+ + L+ E++A ++ +
Sbjct: 456 FKQKLCRAEQAF------QASQIKENELRR--SMEEMKKENNLLKSHSEQKA---REVCH 504
Query: 559 AEEETANCKQ-VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E E N KQ +N +++ N ET+ +Q K I+ + EK
Sbjct: 505 LEAELKNIKQCLNQSQNFAEEMKAKNT------SQETMLRDLQEK-INQQENSLTLEKLK 557
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL--LQLKKMATK- 674
++K + +Q DL L H L ++ E+++++LL L+LKK +
Sbjct: 558 LAVADLEKQRDCSQ---DL--LKKREH-HIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Query: 675 -ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQ 733
+ L + + T ++ EKE ++ ++ L+ + ++ +V LE
Sbjct: 612 LKEEKTLFSCWKSENEKLLTQMES-EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
Query: 734 DKEALKKQVKEL------------TSKIS--SVTKTSAGSNTTARRSLTTNSNKLAE--E 777
D+E L +++ L T K++ + + + S+ ++ + K ++
Sbjct: 671 DRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTG 730
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAEL----SLAQKKPKTLIKS----RSLDASDQQ 829
+V+ LE ++ + ++++K+R + LHAE L + K +L+ + RSL A DQQ
Sbjct: 731 QVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ 790
Query: 830 NVDLKRQLQVIEQEASVLRAKTQ-SLEADNEK-----LQTENKKLQL-LKNAKSLRSDKA 882
+I ++ S+ +++ LEAD LQ L+ L++ K + SD
Sbjct: 791 PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD-- 848
Query: 883 LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXX 942
L ++ Q++ E++E L K +++ E S++ + E T + +
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALEN 908
Query: 943 XXXXXXXXXXXXXXXQATLKSLK------DDAQKSFK---PRIPKKPTDLTTKLQL-KKM 992
QA ++ LK +D+ K + + + ++++ + L K+
Sbjct: 909 KEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKRE 968
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE---KEIDEIRSKLSKNDSEFTNEKNRLQ 1049
+E+L E G + + NA L+ ++M K E IDE +S+ ++ EK L
Sbjct: 969 IEELTQENGTLKEI--NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL- 1025
Query: 1050 TEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS---NQCKTLTEEMKNREAQINKLSA 1106
+ + ++ E + KYKA + +NS L N+C +L E KN Q+ + A
Sbjct: 1026 --LQRCEETGNAYED----LSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
Score = 73.7 bits (173), Expect = 6e-12
Identities = 137/706 (19%), Positives = 284/706 (40%), Gaps = 47/706 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE + + + LK +V+ L + + E+ + ++L A A T E +
Sbjct: 2138 IAEKLKERERENDSLKDKVENLERELQMSEENQELVILD--AENSKAEVETLKTQIEEMA 2195
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIE---SELETRPST------EAQTRQIEQLRA 372
KV EL LR EK++LT++I+E + SEL+ S+ E + +I+
Sbjct: 2196 RSLKVFELDLVT--LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253
Query: 373 KLLAAETLCEELMDENEDMKKELRD---LXXXXXXMQDNFREDQA--DEYSSLRRELEQT 427
A E L +L + NE + D + + E+ + LR LE
Sbjct: 2254 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2313
Query: 428 IKNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQREN---RIKELEQEV 482
K + +LK++E AD L+ E E E ++ ++ EN ++ L+ ++
Sbjct: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP-ETVKVSRSSLTRGGSQEDPAQLLRD 541
T+ L+ ++ S+ L K + +++ SS +++ ++
Sbjct: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2433
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---S 598
+ S E L+ QL+ E A +Q ++ + ++ +++ + +
Sbjct: 2434 EKSSTAMEM-LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEE-----TQFHFDLPYLSIFNHMAANNLRKT 653
N ++ +S ++ + ++K EE Q +S + + +
Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2552
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+E N ++ L+ K ++++ L T ++++ N E E + +M +
Sbjct: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEV----LQSSYKNLENELELTKMDKMSFV 2608
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
++N+ A K EL+++ + ++ EL ++S AG + ++ ++
Sbjct: 2609 EKVNKMTA-----KETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663
Query: 774 LAEERVK--VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
L E ++ L+ +D + K +EKE AE L + + ++ LD + Q V
Sbjct: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL-NTKKT 890
+++ + + + L +Q LE D K E L + L K + N K
Sbjct: 2724 EIQTYREKLTSKEECL--SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYV 2781
Query: 891 TQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
QL+ E + A K+K L C+ + EK++ E ++ + K K
Sbjct: 2782 NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK 2827
Score = 71.3 bits (167), Expect = 3e-11
Identities = 195/1097 (17%), Positives = 402/1097 (36%), Gaps = 60/1097 (5%)
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
++ D ++L ++ E L +E+ ++ E+L ++KEL SK+ + + +
Sbjct: 1765 NQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLH-LQEVQLMTKIE 1823
Query: 763 ARRSLTTNSNKLAEERVKVLE--DEIDEVRKKLIEKERDCERLHAELSL-AQKKPKTLIK 819
A L +L +E + E + ++L+++ E L+++L + A K + I
Sbjct: 1824 ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIG 1883
Query: 820 SRSLDASD---QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
+D ++ +D++ +L I E + + + LEAD E +QTE KL L K+ ++
Sbjct: 1884 DNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE--KLCLEKDNEN 1941
Query: 877 LRS-----DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
+ ++ L + T + QL EL K L+ + EK ++K + E +++
Sbjct: 1942 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL--SEKMKEKTQ--ELESHQSE 1997
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS---LKDDAQKSFKPRIPKKPTDLTTKLQ 988
L Q LK L++ Q K T + Q
Sbjct: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2057
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKE-MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+ ++ ++ E + E + S E + LE + E + + + S E ++
Sbjct: 2058 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE-KGEFALRLSSTQEEVHQ 2116
Query: 1048 LQTEIAKLKDVNAKLEGDKDV-FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
L+ I KL+ V + + K + A K K E EN +L ++ + L E++ E +
Sbjct: 2117 LRRGIEKLR-VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVIL 2175
Query: 1107 DLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDK 1166
D +N+ + T+ + +N TK Q+K L E+
Sbjct: 2176 DAENSKAEVETLK---TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKL 2232
Query: 1167 TKKIGDXXXXXXXXXXXCKRIEK-QLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-- 1223
K K + ++++ ++ T + L
Sbjct: 2233 LSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPP 2292
Query: 1224 IE----LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
IE L + ++L+AR E K + + ++++ + + +E+ ++
Sbjct: 2293 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2352
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
E A + N K + T ++ M + E N +L+K + S +
Sbjct: 2353 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
+ + ++ L + E + E L ++++
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLS 2472
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS------LALEKA 1453
V+ + E A L L + N + L QE E+ +KLE L +
Sbjct: 2473 SQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ 2532
Query: 1454 EYEELTGKYELLEEEHVVTKAR------LTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
+ E+L K +E EH + K + LTVE EQ L L L +++ +
Sbjct: 2533 DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2592
Query: 1508 LGTESAAWNTEK---TEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
L E +K E N + + + L E+ + + + + R A + +
Sbjct: 2593 LENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQL 2652
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
+LE + + + + + ++EK +A
Sbjct: 2653 LLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQA 2712
Query: 1625 EITDTKTRYEGQMNTMRDELKSLHN-------QVSRFRRERDNYKQMLEAAQKSMAEIKN 1677
+ DT +YE ++ T R++L S ++ + ++ L+A + + E+K
Sbjct: 2713 LLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2772
Query: 1678 GDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA- 1736
+ N + + E + K+ LL + LE+E + S+L +K+
Sbjct: 2773 TKMDNLKYVNQLKK-ENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV 2831
Query: 1737 -EVRLAEMQSRLNEYEE 1752
+ ++ E+ + + E +E
Sbjct: 2832 MDTKVDELTTEIKELKE 2848
Score = 70.9 bits (166), Expect = 4e-11
Identities = 183/904 (20%), Positives = 358/904 (39%), Gaps = 80/904 (8%)
Query: 289 RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ-KVNELTTHNEDLRDE----KKHL 343
+ E +K + ++L N K R+ + + Q K NEL E+++ E K H
Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
Query: 344 TQKIREI---ESELETRPSTEAQTRQI-EQLRAKLLAAETLCEELMD-----EN----ED 390
QK RE+ E+EL+ Q++ E+++AK + ET+ +L + EN E
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
+K + DL QD ++ + L +L +T K + L L+ +++ ++L++
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKRE-HHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
Query: 451 EK-------AEHEKKLLEIVGGPDGMQRE-NRIKE-LEQEVARSTEVALRLQRELAEANS 501
EK +E+EK L ++ + +Q + N ++ L+ + +S E R+ R L
Sbjct: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERV-RTLEMDRE 673
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
+ +L V ++V+V L Q+ + Q +E QL E
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 562 ETANCKQVNPPTFLDK-----------QVMTD-------NIVTCDIHESETVTNSIQNKM 603
+ + Q+ +DK + + D ++VT + H+ + Q M
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 604 IHA--------ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN-LRKTA 654
H+ S PS + + K + Q D S+ + N+ L+K
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLL 713
+ + + L K +S + +KL +T A+ N ET A + K L
Sbjct: 854 EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELT--SKISSVTKTSAGS----NTTARRSL 767
LN++ T + +++EL++ L+ +KEL S+ S+ K S N L
Sbjct: 914 QLLNDKVETE-QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL 972
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKK--LIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
T + L E + +++++ ++K + E+ +ELS K+ K ++ R +
Sbjct: 973 TQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEET 1032
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEA--DNEKLQTENKKLQLLKNAKSLRSDKAL 883
+ DL ++ + +++ S L + +N K + E K K + + A
Sbjct: 1033 GNAYE-DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAF 1091
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ LE E + + E+ + KSE K+E TLK +Q
Sbjct: 1092 AEERNQNLMLELETVQQALR-SEMTDNQNNSKSE-----AGGLKQEIMTLKEEQNKMQKE 1145
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEI 1000
T ++ + + + ++ ++ K Q+ V+++ +
Sbjct: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205
Query: 1001 GEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+V A L KE+ + ++ EKE + + + D E +N ++ EI+ LKD
Sbjct: 1206 YNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCE 1265
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD-LKNATSLQTTM 1118
E ++ +N+N++L +T ++ E L A+ + T L +
Sbjct: 1266 IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR 1325
Query: 1119 SDCM 1122
S+C+
Sbjct: 1326 SECI 1329
Score = 59.3 bits (137), Expect = 1e-07
Identities = 141/786 (17%), Positives = 303/786 (38%), Gaps = 37/786 (4%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELET-RPSTEAQTRQIEQLRAKLLAAETLCE 382
QK+ EL + L+ EK+ ++ +E+ L+ + E + + L+ + +CE
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 383 ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTE 442
L + + EL+ Q NF+E Q + +LEQ +K C+ + ++
Sbjct: 78 SLEKTKQKISHELQ-----VKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAA 132
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSK 502
+ AD + +K+ P ++ ++L+++ + E RL+ E+ +K
Sbjct: 133 QSAD-VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK 191
Query: 503 FTGSNPSLMKVPQPETVKVSRSSLTRGGSQE-DPAQLLRDLQDSLEREADLREQLRNAEE 561
+ + + SS QE P+ L + Q + R D + E+
Sbjct: 192 KASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR-DFSASYFSGEQ 250
Query: 562 ETANCKQVNPPTFLD-KQVMTDNIVTCDIHESETVTN-SIQNKMIHAASTPSSKEKSDSP 619
E + D DN + + + N ++NK+ EK
Sbjct: 251 EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKG 310
Query: 620 PLSIDKTTEETQFHFDLPYLSIF-NHMAANNLRKTAARVEEDNESLLLQLKKMATKARSR 678
++ +E Q + + + N R R + K A + + +
Sbjct: 311 QVN---KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQ--ASTKYTALEQKLK 365
Query: 679 KLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEAL 738
KL+ + + E+A + E++ E E + EL+ Q+ + + +E Q K L
Sbjct: 366 KLTEDLSCQRQNAESARCSLEQKIKE---KEKEFQEELSRQQRS-FQTLDQECIQMKARL 421
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
+++++ + +V + T+ ++ L N + ++ + E + K E R
Sbjct: 422 TQELQQ-AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRA-EQAFQASQIKENELRR 479
Query: 799 DCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADN 858
E + E +L + + K+R + + + ++K+ L + A ++AK S E
Sbjct: 480 SMEEMKKENNLLKSHSEQ--KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
Query: 859 EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE-LKEALAKIKEL-EMICQDEKS 916
LQ +K+ +N+ +L K + +K + LK+ I++L + + + EK
Sbjct: 538 RDLQ---EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE 594
Query: 917 EKK-VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
K + E KKE + LK ++ + L+S + + K +
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLS 1035
K L+ E+L EI ++ V L K + +T+ + E++ K
Sbjct: 655 QIKSHEYNERVRTLEMDRENLSVEIRNLHNV-----LDSKSVEVETQ-KLAYMELQQKAE 708
Query: 1036 KNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+D + E + + ++L LE + +N+ + +L + ++L + +K
Sbjct: 709 FSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768
Query: 1096 NREAQI 1101
+++A +
Sbjct: 769 SKDASL 774
Score = 49.6 bits (113), Expect = 1e-04
Identities = 87/439 (19%), Positives = 188/439 (42%), Gaps = 53/439 (12%)
Query: 270 QDQIEGLKQEVDI----LRKRCERVEKEKSDI-----LLRRLANIDTANKYTTGRSSEV- 319
Q + GL QEV+ L K+ E + + K+ I L+ +L+ ++ ++ ++ E+
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559
Query: 320 ---LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
++L+QK+ L + N L+D + L + +E+ELE T+ + K+ A
Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELEL---TKMDKMSFVEKVNKMTA 2616
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
ET EL E +M ++ +L ++ A E L E++ + + L+
Sbjct: 2617 KET---ELQREMHEMAQKTAELQEELSGEKNRL----AGELQLLLEEIKSSKDQLKELTL 2669
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE-VARSTEVALRLQRE 495
+ + ++ D + +++ E E K+ E + + + R+ E E++ A + + + E
Sbjct: 2670 ENSELKKSLDCMHKDQVEKEGKVREEIA-----EYQLRLHEAEKKHQALLLDTNKQYEVE 2724
Query: 496 LAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQ----DSLEREA 550
+ K T L + + +K S+ L S + Q+L +L+ D+L+
Sbjct: 2725 IQTYREKLTSKEECLSSQKLEIDLLKSSKEEL--NNSLKATTQILEELKKTKMDNLKYVN 2782
Query: 551 DLREQLRNAEEE----TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHA 606
L+++ A+ + +CKQ+ +K+++ + + + T ++ + +
Sbjct: 2783 QLKKENERAQGKMKLLIKSCKQLEE----EKEILQKELSQLQAAQEKQKTGTVMDTKVDE 2838
Query: 607 ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
+T + K ++++ T+E + D Y S+ ++ L K +E L
Sbjct: 2839 LTTEIKELKE-----TLEEKTKEADEYLD-KYCSLL--ISHEKLEKAKEMLETQVAHLCS 2890
Query: 667 QLKKMATKARSRKLSPTPP 685
Q K ++ S L P P
Sbjct: 2891 QQSKQDSRG-SPLLGPVVP 2908
Score = 49.2 bits (112), Expect = 1e-04
Identities = 128/666 (19%), Positives = 260/666 (39%), Gaps = 44/666 (6%)
Query: 648 NNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPT--PPANKLSIETANDNDEKETDEA 705
+ L+K + + +SL L+K K + K T N+ +E ++ + +
Sbjct: 28 DKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKIS 87
Query: 706 DPAEMKLLLELNEQEATVL--RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
++K ++N QE + ++++E+LEQ+ + K ++ E + + + S T
Sbjct: 88 HELQVKES-QVNFQEGQLNSGKKQIEKLEQELKRCKSEL-ERSQQAAQSADVSLNPCNTP 145
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER---DCERLHAELSLAQKKPKTLIKS 820
++ TT ED ++ K++ E++R + + L A+ + +Q P+ +
Sbjct: 146 QKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKA-SQTLPQATMNH 204
Query: 821 RSL---DASDQ----QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK- 872
R + AS Q L Q + R + S + +++ LQ+ K
Sbjct: 205 RDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKR 264
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+A S D + + QL+ + +E KI ELE+ Q + E K + + + +
Sbjct: 265 DANSSFFDNSSSPHL--LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQL 322
Query: 933 LKSK-QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKK 991
K+K + Q S K A + ++ K DL+ + Q +
Sbjct: 323 EKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA---LEQKLKKLTEDLSCQRQNAE 379
Query: 992 MVE-DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
LE +I E + LS ++ + +T L++E +++++L++ + N N LQ
Sbjct: 380 SARCSLEQKIKEKEKEFQEE-LSRQQRSFQT-LDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALEN--ENSNL-SNQCKTLTEEMKNREAQINKLSAD 1107
E+ KL V +LE + + F K E + S + N+ + EEMK + S
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497
Query: 1108 -LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQV-DNYTKIDQDKNKLLKEVGD 1165
+ L+ + + + D KI+Q +N L E
Sbjct: 498 KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE--- 554
Query: 1166 KTK-KIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI 1224
K K + D K+ E + D+++ +A++ A ++
Sbjct: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS-----KTEKESKALLSALELKKKEY 609
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR 1284
E E+ L + + K +T +M K + ++KI LE+ + + + + + +R
Sbjct: 610 EELKEEKTLFSCWKSENEKLLT---QMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666
Query: 1285 QTTNDK 1290
D+
Sbjct: 667 TLEMDR 672
Score = 44.4 bits (100), Expect = 0.004
Identities = 53/261 (20%), Positives = 112/261 (42%), Gaps = 19/261 (7%)
Query: 154 QTQLAITKND--SLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYK-- 209
+ +L +TK D S E+V KM +T+ E +K E + +++ +
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
Query: 210 -DERSSTKDDVNFLM----QVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXX----XX 260
+E S+KD + L ++K S + + + G
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2713
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
L+D+N K+Y+ +I+ ++++ ++ C +K + D+L ++ + K TT E+
Sbjct: 2714 LLDTN-KQYEVEIQTYREKLTS-KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK 2771
Query: 321 KLQQK----VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
K + VN+L NE + + K L + +++E E E +Q + ++ +
Sbjct: 2772 KTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV 2831
Query: 377 AETLCEELMDENEDMKKELRD 397
+T +EL E +++K+ L +
Sbjct: 2832 MDTKVDELTTEIKELKETLEE 2852
Score = 44.0 bits (99), Expect = 0.006
Identities = 170/870 (19%), Positives = 353/870 (40%), Gaps = 84/870 (9%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
++ + V + +E KQ L+K+CE + + K +I + + S +
Sbjct: 827 ILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS 886
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
KLQ+ + + H + + L K +E++ L + TE Q E ++ L ++L
Sbjct: 887 KLQE---DTSAHQNVVAETLSALENKEKELQL-LNDKVETE-QAEIQELKKSNHLLEDSL 941
Query: 381 CE-ELMDENEDM-KKELRDLXXXXXXMQDNFREDQA---DEYSSLRRELEQTIKNCRVLS 435
E +L+ E + KKE+ + + ++ + +SL +E I+ +
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
+ + E+ +L + + + LL+ + N ++L Q+ + E +L+
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRC-----EETGNAYEDLSQKYKAAQEKNSKLECL 1056
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ-LLRDLQDSLER-EADLR 553
L E S L ++ + K + LT+ E+ Q L+ +L+ + +++
Sbjct: 1057 LNECTSLCENRKNELEQLKE-AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
+ N++ E KQ T ++Q V + E+E + ++ K H S+
Sbjct: 1116 DNQNNSKSEAGGLKQ-EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK--HECQNLESE 1172
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN-ESLLLQLKKMA 672
+S ++ +E Q +F P + + V+E + +S QL ++
Sbjct: 1173 PIRNSVK---ERESERNQCNFK-PQMDL--------------EVKEISLDSYNAQLVQLE 1214
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE 732
R+++L + E E +T D E L ++ QE + L K E++
Sbjct: 1215 AMLRNKELK----LQESEKEKECLQHELQTIRGD-LETSNLQDMQSQEISGL--KDCEID 1267
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERV-KVLEDEIDEVR 790
+++ + + TS+ N + SL T NKL E E++ ++L+ E E+
Sbjct: 1268 AEEKYISGPHELSTSQ---------NDNAHLQCSLQTTMNKLNELEKICEILQAEKYELV 1318
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSL-DASDQQNVDLKRQL---QVIEQEASV 846
+L + +C + A +A++ K L + + L D S + +L + + EQ
Sbjct: 1319 TELNDSRSEC--ITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQ 1376
Query: 847 LRAKTQSLEADN--EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
L+ N E L +K++Q+ + L+ +K L L ++ L ++ + +K+
Sbjct: 1377 HPVSLAPLDESNSYEHLTLSDKEVQM--HFAELQ-EKFLSLQSEHKI-LHDQHCQMSSKM 1432
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
EL+ K+E V T + D +K Q ++L SL
Sbjct: 1433 SELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQ--LGLEEGLVPSLSSSCVPDSSSLSSL 1490
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYV-VMKNAGLSGKEM-TAKTK 1022
D SF + ++ D++ L+ V +C + E++ ++ L+ KE +A K
Sbjct: 1491 GD---SSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAK 1547
Query: 1023 LEKEIDEI----RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALEN 1078
+E++ + R L K + + ++ EI +L+ + + + D +Y +
Sbjct: 1548 GVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYL---S 1604
Query: 1079 ENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
EN + ++T EM+++ A K + L
Sbjct: 1605 ENEQWQQKLTSVTLEMESKLAAEKKQTEQL 1634
Score = 39.1 bits (87), Expect = 0.16
Identities = 37/167 (22%), Positives = 72/167 (43%), Gaps = 12/167 (7%)
Query: 1617 QSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIK 1676
Q+ + ++ E+ + + + N ++ + +V E N KQ L +Q E+K
Sbjct: 468 QASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK 527
Query: 1677 NGDKSARIHRNSI--------SSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
+ S + +S E+ + VA LE+Q C +D L + +LN +
Sbjct: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
Query: 1729 LVSEKSSAEVRLAEMQSRLNEY----EEERLLSSGRARVAGLATRME 1771
L + ++ L+ ++ + EY EE+ L S ++ L T+ME
Sbjct: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME 634
Score = 39.1 bits (87), Expect = 0.16
Identities = 85/406 (20%), Positives = 168/406 (41%), Gaps = 48/406 (11%)
Query: 1376 KAKELDTDLQSERKK-LDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK 1434
K KE +L+S + + L +++A + +VK K L TL + L ++ T L
Sbjct: 1983 KMKEKTQELESHQSECLHCIQVA-EAEVKEKTELLQTLSSDVSELLKDK-------THL- 2033
Query: 1435 QEYEETVKKLEHSLALEKAEYE----ELTGKYELLEEEHVVTKARLTVEKEQAQGELLHV 1490
QE ++++K +L+L K E E +L + ELL +E +ARL+ ++ E L+V
Sbjct: 2034 QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLS----ESDYEKLNV 2089
Query: 1491 QKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD 1550
K L AL E + + ++ E +++ I L+ R+ E ++ + +L
Sbjct: 2090 SKALEAALVE----KGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD--EKKQLHIAEKLK 2143
Query: 1551 QRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXX 1610
+RERE + D+ + LE + + + Q
Sbjct: 2144 ERERENDSLKDKVENLER-----------------ELQMSEENQELVILDAENSKAEVET 2186
Query: 1611 XXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
IE+ ++ K D T + + +++ Q+S + ++K +LE ++
Sbjct: 2187 LKTQIEEMARSLKVFELDLVT-LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ 2245
Query: 1671 SMAEIKNGDKSA-RIHRNSISSTDE--EEYRNKVALLEQQVACLEDELCESRLLASKLNT 1727
+ +IK K+A + +N + +E +++ L+ + E L + +
Sbjct: 2246 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305
Query: 1728 ELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA 1773
++ + +L +Q +L E E L G RV L +E+A
Sbjct: 2306 LRARLEADEKKQLCVLQ-QLKESEHHADLLKG--RVENLERELEIA 2348
Score = 38.3 bits (85), Expect = 0.28
Identities = 61/305 (20%), Positives = 126/305 (41%), Gaps = 29/305 (9%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYE---NKITSLESTIAAKDVHIKQL-- 1279
+LT + ++L+ + ++ + + +DL A+YE + + S ++++ + H + L
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786
Query: 1280 ---EDALRQT-TNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
+ A+ + N ++ + P E E R Q+ +++ + LE + +
Sbjct: 787 FDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMN 846
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD---------LQS 1386
S + + +L ++E +S +K +E DT L +
Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE-DTSAHQNVVAETLSA 905
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
K +++ +DK V+ + AE+ LK +LE + K + L + K++
Sbjct: 906 LENKEKELQLLNDK-VETEQAEIQELKKSNHLLEDS----LKELQLLSETLSLEKKEMSS 960
Query: 1447 SLALEKAEYEELTGKYELLEEEHV---VTKARLTVEKEQAQGELLHVQKELSTALGEIKT 1503
++L K E EELT + L+E + K L + E + +K +S + K
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYK- 1019
Query: 1504 LQEKL 1508
QEKL
Sbjct: 1020 -QEKL 1023
Score = 37.5 bits (83), Expect = 0.48
Identities = 65/342 (19%), Positives = 134/342 (39%), Gaps = 14/342 (4%)
Query: 1228 SEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTT 1287
S+ ++L+ ++ K + LEAE++ L+A ++ T ++T+ +D+ Q ++
Sbjct: 162 SKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQ-TLPQATMNHRDIARHQASSSVFSWQ 220
Query: 1288 NDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS-----AAKLEM 1342
+K S + + + +++ K +A SS ++ +
Sbjct: 221 QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280
Query: 1343 AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK-- 1400
QLK+ +L N NK +EL L+ + +L +K
Sbjct: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCR 340
Query: 1401 -DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
++ A+ K LEQ + ++ +Q E LE + ++ E++E
Sbjct: 341 DELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEEL 400
Query: 1460 GK----YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT-ESAA 1514
+ ++ L++E + KARLT E +QA+ +Q EL + L+ L +
Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL 460
Query: 1515 WNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQREREL 1556
E+ + I + R + E L + +Q+ RE+
Sbjct: 461 CRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREV 502
Score = 36.3 bits (80), Expect = 1.1
Identities = 59/315 (18%), Positives = 117/315 (37%), Gaps = 19/315 (6%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
L ++ ++ E Q + + F TL+ E +KA ++ ++ + +L
Sbjct: 385 LEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTS 444
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL- 1340
+Q N+ +E + E E + L K+ +E A ++
Sbjct: 445 VKQQLENN-LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
Query: 1341 ----EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
E+ +K L + +N + K + + L E+ KL +
Sbjct: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
Query: 1397 AHDKD-----VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALE 1451
+D +K ++ + L KL E+ S A + K+EYEE +K+ + +
Sbjct: 564 EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE-LKEEKTLFSCW 622
Query: 1452 KAEYEELTGKYELLEE------EHVVTKARLTVEKEQAQGELLH-VQKELSTALGEIKTL 1504
K+E E+L + E +E H+ T + K E + ++ + EI+ L
Sbjct: 623 KSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNL 682
Query: 1505 QEKLGTESAAWNTEK 1519
L ++S T+K
Sbjct: 683 HNVLDSKSVEVETQK 697
>AF273042-1|AAG34902.1| 685|Homo sapiens CTCL tumor antigen se1-1
protein.
Length = 685
Score = 83.4 bits (197), Expect = 7e-15
Identities = 136/677 (20%), Positives = 294/677 (43%), Gaps = 48/677 (7%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++++ KE++ +I L + + L K+CE EK +I + ++ K T+ + +
Sbjct: 4 IEASAKEHEAEINKLNELKENLVKQCEASEK---NIQKKYECELENLRKATSNANQDNQI 60
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETL 380
+ E T + + ++ KHL ++E+ES+ + + + L+ KL + A+ +
Sbjct: 61 CSILLQENTFVEQVVNEKVKHLEDTLKELESQ---HSILKDEVTYMNNLKLKLEMDAQHI 117
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK--NCRVLSFKL 438
+E E ED++ ++ +L Q E E + L ++ T++ N V S K
Sbjct: 118 KDEFFHEREDLEFKINELLLAKEE-QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE 176
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGM--QRENRIKELEQEVAR---STEVALRLQ 493
+ + ++ E ++ EK+ L ++ G+ Q EN +E ++ + E+ LQ
Sbjct: 177 QHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQ 236
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP-AQLLRDLQDSLEREADL 552
EL E+ K + S MK Q V + L +++D + + LQ E+
Sbjct: 237 TELGESAGKISQEFES-MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ 295
Query: 553 REQLRNAEEETANCKQVNPPTFL---DKQVMTDNI---VTCDIHESETVTNSIQNKMIHA 606
+E + E N ++ N L + M + + E + N ++N
Sbjct: 296 QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEM 355
Query: 607 ASTPSSKEKSDSPPLSIDKTTEET-QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
+ E+ + L + K E+T Q++ +L N + L +T +++++ L
Sbjct: 356 DNFHKKCEREERLILELGKKVEQTIQYNSELE--QKVNEL-TGGLEETLKEKDQNDQKLE 412
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLE--LNEQEATV 723
+ +M + +++ + L ET N +K+ D E + ++ T
Sbjct: 413 KLMVQMKVLSEDKEVL-SAEVKSLYEETINSVQKKKQLSRDLEVFLSQKEDVILKEHITQ 471
Query: 724 LRRKVEELEQDKEALKKQVK-ELTSKISSVTKT--------SAGSNTTARRSLTTNSNKL 774
L +K++ + ++++ L K ++ E K+ T+ S S + + + +
Sbjct: 472 LEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAV 531
Query: 775 AEERVKVLEDEID---EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
E K+ E++ + + +K++E E++ + L E + ++ K+L++ +Q+ V
Sbjct: 532 GESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRD-----YEQEKV 586
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT 891
L+++L+ I+ E L++ ++ NEK + EN+ L + S K+ N K+
Sbjct: 587 LLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKC 646
Query: 892 QL-ENELKEALAKIKEL 907
+ E+E + L + KEL
Sbjct: 647 FIKEHENLKPLLEQKEL 663
Score = 42.3 bits (95), Expect = 0.017
Identities = 99/586 (16%), Positives = 229/586 (39%), Gaps = 21/586 (3%)
Query: 540 RDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD--IHESETVT 596
+++Q E E + LR+ NA ++ C + +QV+ + + + + E E+
Sbjct: 34 KNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQH 93
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAAR 656
+ +++++ + + K + D+ + + E F + L + + K +
Sbjct: 94 SILKDEVTYMNNL-KLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSE 152
Query: 657 VEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDND-EKETDEADPAEMKLLLE 715
+ N+ +++ + +S K ++L+ +D++ EK T + +K E
Sbjct: 153 LAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCE 212
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
+QE E L + E L+ ++ E KIS ++ + L
Sbjct: 213 NLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAF 272
Query: 776 EERVKVLE--DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDL 833
E+ +LE + + +KL+ ++ L + Q+K + S S + + ++
Sbjct: 273 TEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEG 332
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
K E++ + + K E DN + E ++ +L+ K + ++ + N++ Q
Sbjct: 333 KINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKV--EQTIQYNSE-LEQK 389
Query: 894 ENELKEALAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXX 952
NEL L + +KE + D+K EK + + ++ + L ++
Sbjct: 390 VNELTGGLEETLKEKDQ--NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEETINSVQKKK 447
Query: 953 XXXXXQATLKSLKDDA-------QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYV 1005
S K+D Q K ++ + D KL + V+ L + ++Y
Sbjct: 448 QLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKT-QLYG 506
Query: 1006 VMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
+K G E + + + + + L+K + E N + ++ +L+ L+ +
Sbjct: 507 FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEE 566
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
V + K+L + + EE+++ + + ++KNA
Sbjct: 567 SVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNA 612
Score = 35.5 bits (78), Expect = 2.0
Identities = 49/272 (18%), Positives = 112/272 (41%), Gaps = 19/272 (6%)
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
K+ D +L L ++K+L ++ + E+K YEET+ ++ L + L+
Sbjct: 402 KEKDQNDQKLEKLMVQMKVLSEDKEVLS---AEVKSLYEETINSVQKKKQLSRDLEVFLS 458
Query: 1460 GKYELLEEEHVV---TKARLTVEKEQAQGELL-HVQKELSTALGEIKTLQEKLGTESAAW 1515
K +++ +EH+ K +L VE++ +LL + Q + ++ +++G+E +
Sbjct: 459 QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSE-VSE 517
Query: 1516 NTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXX 1575
++E+ ++ N + ++ E L ++ + N + E+ L + + + E
Sbjct: 518 DSEEKDVVNVLQAVGESLA----KINEEKCNLAFQRDEKVLELEKEIKCLQEE----SVV 569
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
DYE+ + R ++ + + + E + + E
Sbjct: 570 QCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE 629
Query: 1636 QMNTMRDELKSLHNQVSR-FRRERDNYKQMLE 1666
T +HN+ + F +E +N K +LE
Sbjct: 630 VSQTC--SKSEIHNEKEKCFIKEHENLKPLLE 659
Score = 33.5 bits (73), Expect = 7.9
Identities = 63/327 (19%), Positives = 129/327 (39%), Gaps = 15/327 (4%)
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
+L+ T + NEK++ L+ L++ S+ D+ +N K +LE + + IK
Sbjct: 64 LLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKL-KLEMDAQH----IK 118
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
+ E + E E K+ K+E + K + ++SLK
Sbjct: 119 D-EFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNRE--VQSLK 175
Query: 966 DDAQKSFKPRIPKKPTDLTT-KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-L 1023
+ QK +D KL L ++ L+ + + + A L+ + + + L
Sbjct: 176 EQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEIL 235
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
+ E+ E K+S+ EF + K + +++ +L+ +KD L+ EN L
Sbjct: 236 QTELGESAGKISQ---EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKL 292
Query: 1084 SNQCKTLTEEMKNREAQI-NKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXX 1142
+Q + L E++N + K L + + T + +
Sbjct: 293 LSQ-QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNS 351
Query: 1143 XXQVDNYTKIDQDKNKLLKEVGDKTKK 1169
++DN+ K + + +L+ E+G K ++
Sbjct: 352 HEEMDNFHKKCEREERLILELGKKVEQ 378
>U19769-1|AAA82889.1| 3210|Homo sapiens CENP-F kinetochore protein
protein.
Length = 3210
Score = 83.0 bits (196), Expect = 1e-14
Identities = 170/871 (19%), Positives = 348/871 (39%), Gaps = 85/871 (9%)
Query: 314 GRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQ-KIREIESELETRPSTEAQTRQIE-QLR 371
G ++ LQ +V E T NE+LR H+ + + R++ES L +++ E QL
Sbjct: 1860 GNQEDIHNLQLRVKE--TSNENLR--LLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLM 1915
Query: 372 AKLLAA---ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ---AD-EYSSLRREL 424
K+ A E + EL EN D+ ++L + + +D E + +
Sbjct: 1916 TKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSR 1975
Query: 425 EQTIKNCRVLSFKLKK----TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQ 480
E N ++ K+ E + ++ EKA E + L + + +Q E E +
Sbjct: 1976 EDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN 2035
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
E +V + L+ EL+ S+ L + + T S + +QE +
Sbjct: 2036 E--NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSE 2093
Query: 541 DLQDSLEREADLREQLRNAEEETANCKQV--------NPPTFLDKQVMTDNIVTCDIHES 592
L EA+++E+ + +++ ++ L+K ++ C++
Sbjct: 2094 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2153
Query: 593 ETVTNSIQNKMIHAASTPSSK-EKSDSPPLSIDKT-----TEETQFHFDLPYLSIFNHMA 646
N + ++ + + ++ +SD L++ K E+ +F L H
Sbjct: 2154 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQL 2213
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDE-----K 700
+ K R+E D + L +K+ + R N + ++ + +N E
Sbjct: 2214 RRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDA 2273
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK--TSAG 758
E +A+ +K +E + V + L +KE L KQ++E ++S + K +S
Sbjct: 2274 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2333
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKL--------------------IEKER 798
S + + ++ V++L++++ E+ + + IE+E
Sbjct: 2334 SLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2393
Query: 799 DC----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ-- 852
E+L A L +KK +++ L S+ LK +++ +E+E + R +
Sbjct: 2394 QLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADLLKGRVENLERELEIARTNQEHA 2451
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ--LENELKEALAKIKELEMI 910
+LEA+N K + E K ++ +SLR + LD+ T ++ + L NEL++ +I ELE+I
Sbjct: 2452 ALEAENSKGEVETLKAKIEGMTQSLRGLE-LDVVTIRSEKEDLTNELQKEQERISELEII 2510
Query: 911 CQD------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
EK ++KV+ E + + L+++ + L S
Sbjct: 2511 NSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2570
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL--ECEIGEMYVVMKNAGLSG--KEMTAK 1020
+ + + + L+ V L E E G+ + K+ +S ++ +
Sbjct: 2571 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ 2630
Query: 1021 TKLEKEIDEIRSK---LSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+L ++ ++ + + + E N L+ +I L+ NA L+ +V + YK LE
Sbjct: 2631 EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLE 2690
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
NE + E++ A+ +L ++
Sbjct: 2691 NELELTKMDKMSFVEKVNKMTAKETELQREM 2721
Score = 83.0 bits (196), Expect = 1e-14
Identities = 184/875 (21%), Positives = 356/875 (40%), Gaps = 72/875 (8%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSE-VLKL---Q 323
E ++QI L +E ++L K E ++ S+ +L N+ A + E L+L Q
Sbjct: 2149 ELENQIAQLNKEKELLVKESESLQARLSESDYEKL-NVSKALEAALVEKGEFALRLSSTQ 2207
Query: 324 QKVNELTTHNEDLR-----DEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
++V++L E LR DEKK H+ +K++E E E ++ ++E L +L
Sbjct: 2208 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE------NDSLKDKVENLERELQM 2261
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
+E E ++ + E+ K E+ L M + + + D +LR E E K +
Sbjct: 2262 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD-LVTLRSEKENLTKQIQEKQG 2320
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR--ENRIKELEQEVAR---STEVALR 491
+L + ++ + E E+ ++I +N++KEL + VA E+
Sbjct: 2321 QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2380
Query: 492 LQREL---AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
++ L E + S L + + K L + E A LL+ ++LER
Sbjct: 2381 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKK-QLCVLQQLKESEHHADLLKGRVENLER 2439
Query: 549 EADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNI--VTCDI----HESETVTNSIQN 601
E ++ R +A E N K + MT ++ + D+ E E +TN +Q
Sbjct: 2440 ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQK 2499
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
+ + ++ + +K E+ Q L + A + D
Sbjct: 2500 EQERISELEIINSSFEN--ILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2557
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE--Q 719
E A KA+ + LS L +E A + DEA + L +N Q
Sbjct: 2558 E---------ACKAKEQNLSSQVEC--LELEKAQLL--QGLDEAKNNYIVLQSSVNGLIQ 2604
Query: 720 EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT-NSNKLAEER 778
E ++K+E+ +++ LK Q+++ +S +++ ++L N E++
Sbjct: 2605 EVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQK 2664
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
++VL+ + ++ L + + L EL L + + ++ ++ + +L+R++
Sbjct: 2665 IQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK--VNKMTAKETELQREMH 2722
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
+ Q+ + L+ + L + +L E LQLL D+ +L T + ++L+ L
Sbjct: 2723 EMAQKTAELQ---EELSGEKNRLAGE---LQLLLEEIKSSKDQLKEL-TLENSELKKSLD 2775
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKET----DTLKSKQXXXXXXXXXXXXXXXXX 954
E E ++E +E ++R EA KK DT K +
Sbjct: 2776 CMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECL 2835
Query: 955 XXXQAT---LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAG 1011
+ LKS K++ S K TK+ K V L+ E MK
Sbjct: 2836 SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLI 2895
Query: 1012 LSGKEMTAKTK-LEKEIDEIRS--KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
S K++ + + L+KE+ ++++ + K + + + L TEI +LK+ + + D
Sbjct: 2896 KSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2955
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
+ +KY +L + L + L ++ + +Q +K
Sbjct: 2956 YLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSK 2990
Score = 81.8 bits (193), Expect = 2e-14
Identities = 178/923 (19%), Positives = 379/923 (41%), Gaps = 93/923 (10%)
Query: 648 NNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP 707
N LR + + +L +KM K + + + + + + A ++ E +
Sbjct: 2057 NQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLS 2116
Query: 708 AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA----GSNTTA 763
+++ LL+ + T L+ K++ LE+D +AL EL ++I+ + K S +
Sbjct: 2117 SDVSELLK----DKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ 2172
Query: 764 RRSLTTNSNKL----AEERVKVLEDE----IDEVRKKLIEKERDCERLHAELSLAQKKPK 815
R ++ KL A E V + E + ++++ + R E+L + +KK
Sbjct: 2173 ARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL 2232
Query: 816 TLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS--LEADNEKLQTENKKLQLLKN 873
+ + L +++N LK +++ +E+E + + L+A+N K + E K Q+ +
Sbjct: 2233 HI--AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM 2290
Query: 874 AKSLRSDKALDLNTKKTTQ--LENELKEALAKIKELEMICQ------DEKSEKKVRFTEA 925
A+SL+ + LDL T ++ + L +++E ++ EL+ + +EK + +++ E
Sbjct: 2291 ARSLKVFE-LDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2349
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS-LKDDAQ-----KSFKPRIP-- 977
+K + L+++ + +L ++++ Q + + R+
Sbjct: 2350 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2409
Query: 978 -KKPTDLTTKLQ--------LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKL 1023
KK + +L+ LK VE+LE E+ + + ++ G+ T K K+
Sbjct: 2410 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2469
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
E +R L + +EK L E+ K ++ ++LE F N + E E +
Sbjct: 2470 EGMTQSLRG-LELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENILQEKEQEKVQM 2528
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
+ T E ++ + ++N+ A L N +
Sbjct: 2529 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2588
Query: 1144 XQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXX 1203
+NY + N L++EV D +K+ R++ Q+ ++ V+
Sbjct: 2589 K--NNYIVLQSSVNGLIQEVEDGKQKL-------EKKDEEISRLKNQIQDQEQLVSKLS- 2638
Query: 1204 XXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKIT 1263
Q + ++EL + EL+ + +SK +L+ + L++ Y+N
Sbjct: 2639 -------QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN 2691
Query: 1264 SLESTIAAKDVHIKQLEDALRQTT---NDKYDEATSPVEM-VEMRXXXXXXXXXXXXXQD 1319
LE T K ++++ + T + ++ A E+ E+ +
Sbjct: 2692 ELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE 2751
Query: 1320 ELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE 1379
E+ ++K +L++ E+S K + + D + E + +++A
Sbjct: 2752 EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEK-KHQALL 2810
Query: 1380 LDTDLQSERK-KLDRMRIAHDKD-VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
LDT+ Q E + + R ++ ++ + ++ E+ LK + L + A + + ELK+
Sbjct: 2811 LDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2870
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYEL-------LEEEHVVTKARLT----VEKEQAQGE 1486
+ +K + K E E GK +L LEEE + + L+ +++Q G
Sbjct: 2871 MDNLKYVNQL----KKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGT 2926
Query: 1487 LLHVQ-KELSTALGEIK-TLQEK 1507
++ + EL+T + E+K TL+EK
Sbjct: 2927 VMDTKVDELTTEIKELKETLEEK 2949
Score = 81.4 bits (192), Expect = 3e-14
Identities = 156/813 (19%), Positives = 332/813 (40%), Gaps = 57/813 (7%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIEQLRA 372
+EV + + + L++ +L +K HL +K++ +E + + T+ E Q Q+ + +
Sbjct: 2103 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2162
Query: 373 KLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR 432
L+ + + E++ K + + F A SS + E+ Q +
Sbjct: 2163 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEF----ALRLSSTQEEVHQLRRGIE 2218
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV----ARSTEV 488
L +++ E+K + ++ E E++ + + ++RE ++ E QE+ A +++
Sbjct: 2219 KLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKA 2278
Query: 489 ALR-LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
+ L+ ++ E L+ + + E +++ + G + +LL + LE
Sbjct: 2279 EVETLKTQIEEMARSLKVFELDLVTL-RSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE 2337
Query: 548 R----EADLREQLRNAEEETAN-CKQVNPPTFL---DKQVM--TDNIVTCDIHESETVTN 597
E ++E+ + A E N K++N D+++M T+ + I E + N
Sbjct: 2338 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 2397
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN-----HMAANNLRK 652
SI+ + E + L + + +E++ H DL + N +A N
Sbjct: 2398 SIE-------KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH 2450
Query: 653 TAARVEEDN---ESLLLQLKKMATKARSRKLS-PTPPANKLSIETANDNDEKETDEADPA 708
A E E+L +++ M R +L T + K + +++ E +
Sbjct: 2451 AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEII 2510
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
L E+E ++ K E+ E L+ Q+KEL +++++ ++L+
Sbjct: 2511 NSSFENILQEKEQEKVQMK-EKSSTAMEMLQTQLKELNERVAALHNDQEACK-AKEQNLS 2568
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA-QKKPKTLIKSRSLDASD 827
+ L E+ ++L+ +DE + I + L E+ QK K + L
Sbjct: 2569 SQVECLELEKAQLLQG-LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 2627
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
Q L +L +E E + K Q+LE N ++ E +K+Q+L++ + D L++
Sbjct: 2628 QDQEQLVSKLSQVEGEHQLW--KEQNLELRNLTVELE-QKIQVLQSKNASLQD-TLEVLQ 2683
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
LENEL+ L K+ ++ + ++ ++ + TE ++ + +
Sbjct: 2684 SSYKNLENELE--LTKMDKMSFV--EKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2739
Query: 948 XXXXXXXXXXQATLKSLKDDAQK-SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVV 1006
+KS KD ++ + + KK D K Q++K + E EI E +
Sbjct: 2740 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE-EIAEYQLR 2798
Query: 1007 MKNAGLSGKEMTAKT--KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ A + + T + E EI R KL+ + +++K + + +++N L+
Sbjct: 2799 LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2858
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNR 1097
+ + K + +N NQ K E + +
Sbjct: 2859 TTQIL-EELKKTKMDNLKYVNQLKKENERAQGK 2890
Score = 79.8 bits (188), Expect = 9e-14
Identities = 174/840 (20%), Positives = 353/840 (42%), Gaps = 103/840 (12%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAKLLAAET 379
+L+ K+NEL + E K K +E++ +LE + + + + + R +L+
Sbjct: 289 ELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKL 438
++ + ++++L+ L + N S R LEQ IK + +L
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQN--------AESARCSLEQKIKEKEKEFQEEL 400
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ +R L+QE + + +L + + Q +N L+ E+ + T V +L+ L E
Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQ-----ELQQAKNMHNVLQAELDKLTSVKQQLENNLEE 455
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
K + + + ++ + L R S E+ + L+ E++A ++ +
Sbjct: 456 FKQKLCRAEQAF------QASQIKENELRR--SMEEMKKENNLLKSHSEQKA---REVCH 504
Query: 559 AEEETANCKQ-VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E E N KQ +N +++ N ET+ +Q K I+ + EK
Sbjct: 505 LEAELKNIKQCLNQSQNFAEEMKAKNT------SQETMLRDLQEK-INQQENSLTLEKLK 557
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL--LQLKKMATK- 674
++K + +Q DL L H L ++ E+++++LL L+LKK +
Sbjct: 558 LAVADLEKQRDCSQ---DL--LKKREH-HIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Query: 675 -ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQ 733
+ L + + T ++ EKE ++ ++ L+ + ++ +V LE
Sbjct: 612 LKEEKTLFSCWKSENEKLLTQMES-EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
Query: 734 DKEALKKQVKEL------------TSKIS--SVTKTSAGSNTTARRSLTTNSNKLAE--E 777
D+E L +++ L T K++ + + + S+ ++ + K ++
Sbjct: 671 DRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTG 730
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAEL----SLAQKKPKTLIKS----RSLDASDQQ 829
+V+ LE ++ + ++++K+R + LHAE L + K +L+ + RSL A DQQ
Sbjct: 731 QVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ 790
Query: 830 NVDLKRQLQVIEQEASVLRAKTQ-SLEADNEK-----LQTENKKLQL-LKNAKSLRSDKA 882
+I ++ S+ +++ LEAD LQ L+ L++ K + SD
Sbjct: 791 PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD-- 848
Query: 883 LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXX 942
L ++ Q++ E++E L K +++ E S++ + E T + +
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALEN 908
Query: 943 XXXXXXXXXXXXXXXQATLKSLK------DDAQKSFK---PRIPKKPTDLTTKLQL-KKM 992
QA ++ LK +D+ K + + + ++++ + L K+
Sbjct: 909 KEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKRE 968
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE---KEIDEIRSKLSKNDSEFTNEKNRLQ 1049
+E+L E G + + NA L+ ++M K E IDE +S+ ++ EK L
Sbjct: 969 IEELTQENGTLKEI--NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL- 1025
Query: 1050 TEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS---NQCKTLTEEMKNREAQINKLSA 1106
+ + ++ E + KYKA + +NS L N+C +L E KN Q+ + A
Sbjct: 1026 --LQRCEETGNAYED----LSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
Score = 73.3 bits (172), Expect = 8e-12
Identities = 137/706 (19%), Positives = 284/706 (40%), Gaps = 47/706 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE + + + LK +V+ L + + E+ + ++L A A T E +
Sbjct: 2234 IAEKLKERERENDSLKDKVENLERELQMSEENQELVILD--AENSKAEVETLKTQIEEMA 2291
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIE---SELETRPST------EAQTRQIEQLRA 372
KV EL LR EK++LT++I+E + SEL+ S+ E + +I+
Sbjct: 2292 RSLKVFELDLVT--LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2349
Query: 373 KLLAAETLCEELMDENEDMKKELRD---LXXXXXXMQDNFREDQA--DEYSSLRRELEQT 427
A E L +L + NE + D + + E+ + LR LE
Sbjct: 2350 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2409
Query: 428 IKNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQREN---RIKELEQEV 482
K + +LK++E AD L+ E E E ++ ++ EN ++ L+ ++
Sbjct: 2410 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2469
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP-ETVKVSRSSLTRGGSQEDPAQLLRD 541
T+ L+ ++ S+ L K + +++ SS +++ ++
Sbjct: 2470 EGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2529
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---S 598
+ S E L+ QL+ E A +Q ++ + ++ +++ + +
Sbjct: 2530 EKSSTAMEM-LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2588
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEE-----TQFHFDLPYLSIFNHMAANNLRKT 653
N ++ +S ++ + ++K EE Q +S + + +
Sbjct: 2589 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2648
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+E N ++ L+ K ++++ L T ++++ N E E + +M +
Sbjct: 2649 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEV----LQSSYKNLENELELTKMDKMSFV 2704
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
++N+ A K EL+++ + ++ EL ++S AG + ++ ++
Sbjct: 2705 EKVNKMTA-----KETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2759
Query: 774 LAEERVK--VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
L E ++ L+ +D + K +EKE AE L + + ++ LD + Q V
Sbjct: 2760 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2819
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL-NTKKT 890
+++ + + + L +Q LE D K E L + L K + N K
Sbjct: 2820 EIQTYREKLTSKEECL--SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYV 2877
Query: 891 TQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
QL+ E + A K+K L C+ + EK++ E ++ + K K
Sbjct: 2878 NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK 2923
Score = 70.9 bits (166), Expect = 4e-11
Identities = 183/904 (20%), Positives = 358/904 (39%), Gaps = 80/904 (8%)
Query: 289 RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ-KVNELTTHNEDLRDE----KKHL 343
+ E +K + ++L N K R+ + + Q K NEL E+++ E K H
Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
Query: 344 TQKIREI---ESELETRPSTEAQTRQI-EQLRAKLLAAETLCEELMD-----EN----ED 390
QK RE+ E+EL+ Q++ E+++AK + ET+ +L + EN E
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
+K + DL QD ++ + L +L +T K + L L+ +++ ++L++
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKRE-HHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
Query: 451 EK-------AEHEKKLLEIVGGPDGMQRE-NRIKE-LEQEVARSTEVALRLQRELAEANS 501
EK +E+EK L ++ + +Q + N ++ L+ + +S E R+ R L
Sbjct: 615 EKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERV-RTLEMDRE 673
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
+ +L V ++V+V L Q+ + Q +E QL E
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 562 ETANCKQVNPPTFLDK-----------QVMTD-------NIVTCDIHESETVTNSIQNKM 603
+ + Q+ +DK + + D ++VT + H+ + Q M
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 604 IHA--------ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN-LRKTA 654
H+ S PS + + K + Q D S+ + N+ L+K
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLL 713
+ + + L K +S + +KL +T A+ N ET A + K L
Sbjct: 854 EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELT--SKISSVTKTSAGS----NTTARRSL 767
LN++ T + +++EL++ L+ +KEL S+ S+ K S N L
Sbjct: 914 QLLNDKVETE-QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL 972
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKK--LIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
T + L E + +++++ ++K + E+ +ELS K+ K ++ R +
Sbjct: 973 TQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEET 1032
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEA--DNEKLQTENKKLQLLKNAKSLRSDKAL 883
+ DL ++ + +++ S L + +N K + E K K + + A
Sbjct: 1033 GNAYE-DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAF 1091
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ LE E + + E+ + KSE K+E TLK +Q
Sbjct: 1092 AEERNQNLMLELETVQQALR-SEMTDNQNNSKSE-----AGGLKQEIMTLKEEQNKMQKE 1145
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEI 1000
T ++ + + + ++ ++ K Q+ V+++ +
Sbjct: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205
Query: 1001 GEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+V A L KE+ + ++ EKE + + + D E +N ++ EI+ LKD
Sbjct: 1206 YNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCE 1265
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD-LKNATSLQTTM 1118
E ++ +N+N++L +T ++ E L A+ + T L +
Sbjct: 1266 IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR 1325
Query: 1119 SDCM 1122
S+C+
Sbjct: 1326 SECI 1329
Score = 69.7 bits (163), Expect = 1e-10
Identities = 215/1116 (19%), Positives = 425/1116 (38%), Gaps = 98/1116 (8%)
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
++ D ++L ++ E L +E+ ++ E+L ++KEL SK+ + + +
Sbjct: 1861 NQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLH-LQEVQLMTKIE 1919
Query: 763 ARRSLTTNSNKLAEERVKVLE--DEIDEVRKKLIEKERDCERLHAELSL-AQKKPKTLIK 819
A L +L +E + E + ++L+++ E L+++L + A K + I
Sbjct: 1920 ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIG 1979
Query: 820 SRSLDASD---QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
+D ++ +D++ +L I E + + + LEAD E +QTE KL L K+ ++
Sbjct: 1980 DNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE--KLCLEKDNEN 2037
Query: 877 LRS-----DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
+ ++ L + T + QL EL K L+ + EK ++K + E +++
Sbjct: 2038 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL--SEKMKEKTQ--ELESHQSE 2093
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS---LKDDAQKSFKPRIPKKPTDLTTKLQ 988
L Q LK L++ Q K T + Q
Sbjct: 2094 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2153
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKE-MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+ ++ ++ E + E + S E + LE + E + + + S E ++
Sbjct: 2154 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE-KGEFALRLSSTQEEVHQ 2212
Query: 1048 LQTEIAKLKDVNAKLEGDKDV-FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
L+ I KL+ V + + K + A K K E EN +L ++ + L E++ E +
Sbjct: 2213 LRRGIEKLR-VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVIL 2271
Query: 1107 DLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDK 1166
D +N+ + T+ + +N TK Q+K L E+
Sbjct: 2272 DAENSKAEVETLK---TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKL 2328
Query: 1167 TKKIGDXXXXXXXXXXXCKRIEK-QLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-- 1223
K K + ++++ ++ T + L
Sbjct: 2329 LSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPP 2388
Query: 1224 IE----LTSEKDELQARFIKTESKFITLEAEMRD-------LKADYENKITSLESTIAAK 1272
IE L + ++L+AR E K + + ++++ LK EN LE +
Sbjct: 2389 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2448
Query: 1273 DVHIKQLEDALR--QTTNDKYDEATS-----PVEMVEMRXXXXXXXXXXXXXQDELNNAK 1325
+ + E++ +T K + T +++V +R Q+ ++ +
Sbjct: 2449 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELE 2508
Query: 1326 I---KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDT 1382
I E E K++M + KS A + KAKE +
Sbjct: 2509 IINSSFENILQEKEQEKVQMKE-KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNL 2567
Query: 1383 DLQSERKKLDRMRIAHDKD-VKNKDAEL-ATLKGKLKILEQNSGAGAKR---ITELK--- 1434
Q E +L++ ++ D KN L +++ G ++ +E K+ I+ LK
Sbjct: 2568 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 2627
Query: 1435 QEYEETVKKL-----EHSLALEK-AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELL 1488
Q+ E+ V KL EH L E+ E LT + E + A L E Q
Sbjct: 2628 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 2687
Query: 1489 HVQKELS-TALGEIKTLQE--KLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
+++ EL T + ++ +++ K+ + E EM A LQE L G E+ RL
Sbjct: 2688 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSG-----EKNRL 2742
Query: 1546 NARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
L E++++ D+ + E + E+ K++
Sbjct: 2743 AGELQLLLEEIKSSKDQ--LKELTLENSELKKSLDCMHKDQVEKEGKVRE---------- 2790
Query: 1606 XXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHN-------QVSRFRRER 1658
+ ++EK +A + DT +YE ++ T R++L S ++ + +
Sbjct: 2791 -EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2849
Query: 1659 DNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES 1718
+ L+A + + E+K + N + + E + K+ LL + LE+E
Sbjct: 2850 EELNNSLKATTQILEELKKTKMDNLKYVNQLKK-ENERAQGKMKLLIKSCKQLEEEKEIL 2908
Query: 1719 RLLASKLNTELVSEKSSA--EVRLAEMQSRLNEYEE 1752
+ S+L +K+ + ++ E+ + + E +E
Sbjct: 2909 QKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKE 2944
Score = 54.0 bits (124), Expect = 5e-06
Identities = 141/787 (17%), Positives = 304/787 (38%), Gaps = 39/787 (4%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
QK+ EL + L+ EK+ Q+ +++S LE P + Q + E+ L E +
Sbjct: 18 QKIQELEGQLDKLKKEKQ---QRQFQLDS-LEAAPQKQTQKVENEKTEGTNLKREN--QR 71
Query: 384 LMDENEDMKKELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
LM+ E ++K + + + NF+E Q + +LEQ +K C+ + ++
Sbjct: 72 LMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQA 131
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+ AD + +K+ P ++ ++L+++ + E RL+ E+ +
Sbjct: 132 AQSAD-VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE-DPAQLLRDLQDSLEREADLREQLRNAE 560
K + + + SS QE P+ L + Q + R D + E
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR-DFSASYFSGE 249
Query: 561 EETANCKQVNPPTFLD--KQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDS 618
E + D ++ + + + ++NK+ EK
Sbjct: 250 LEVTPSRSTLQIGKRDANSSFFGNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMK 309
Query: 619 PPLSIDKTTEETQFHFDLPYLSIF-NHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
++ +E Q + + + N R R + K A + +
Sbjct: 310 GQVN---KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQ--ASTKYTALEQKL 364
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEA 737
+KL+ + + E+A + E++ E E + EL+ Q+ + + +E Q K
Sbjct: 365 KKLTEDLSCQRQNAESARCSLEQKIKE---KEKEFQEELSRQQRS-FQTLDQECIQMKAR 420
Query: 738 LKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKE 797
L +++++ + +V + T+ ++ L N + ++ + E + K E
Sbjct: 421 LTQELQQ-AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRA-EQAFQASQIKENELR 478
Query: 798 RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD 857
R E + E +L + + K+R + + + ++K+ L + A ++AK S E
Sbjct: 479 RSMEEMKKENNLLKSHSEQ--KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536
Query: 858 NEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE-LKEALAKIKEL-EMICQDEK 915
LQ +K+ +N+ +L K + +K + LK+ I++L + + + EK
Sbjct: 537 LRDLQ---EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEK 593
Query: 916 SEKK-VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKP 974
K + E KKE + LK ++ + L+S + + K
Sbjct: 594 ESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKT 653
Query: 975 RIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKL 1034
+ K L+ E+L EI ++ V L K + +T+ + E++ K
Sbjct: 654 QQIKSHEYNERVRTLEMDRENLSVEIRNLHNV-----LDSKSVEVETQ-KLAYMELQQKA 707
Query: 1035 SKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEM 1094
+D + E + + ++L LE + +N+ + +L + ++L + +
Sbjct: 708 EFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLL 767
Query: 1095 KNREAQI 1101
K+++A +
Sbjct: 768 KSKDASL 774
Score = 49.6 bits (113), Expect = 1e-04
Identities = 87/439 (19%), Positives = 188/439 (42%), Gaps = 53/439 (12%)
Query: 270 QDQIEGLKQEVDI----LRKRCERVEKEKSDI-----LLRRLANIDTANKYTTGRSSEV- 319
Q + GL QEV+ L K+ E + + K+ I L+ +L+ ++ ++ ++ E+
Sbjct: 2596 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2655
Query: 320 ---LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
++L+QK+ L + N L+D + L + +E+ELE T+ + K+ A
Sbjct: 2656 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELEL---TKMDKMSFVEKVNKMTA 2712
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
ET EL E +M ++ +L ++ A E L E++ + + L+
Sbjct: 2713 KET---ELQREMHEMAQKTAELQEELSGEKNRL----AGELQLLLEEIKSSKDQLKELTL 2765
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE-VARSTEVALRLQRE 495
+ + ++ D + +++ E E K+ E + + + R+ E E++ A + + + E
Sbjct: 2766 ENSELKKSLDCMHKDQVEKEGKVREEIA-----EYQLRLHEAEKKHQALLLDTNKQYEVE 2820
Query: 496 LAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQ----DSLEREA 550
+ K T L + + +K S+ L S + Q+L +L+ D+L+
Sbjct: 2821 IQTYREKLTSKEECLSSQKLEIDLLKSSKEEL--NNSLKATTQILEELKKTKMDNLKYVN 2878
Query: 551 DLREQLRNAEEE----TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHA 606
L+++ A+ + +CKQ+ +K+++ + + + T ++ + +
Sbjct: 2879 QLKKENERAQGKMKLLIKSCKQLEE----EKEILQKELSQLQAAQEKQKTGTVMDTKVDE 2934
Query: 607 ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
+T + K ++++ T+E + D Y S+ ++ L K +E L
Sbjct: 2935 LTTEIKELKE-----TLEEKTKEADEYLD-KYCSLL--ISHEKLEKAKEMLETQVAHLCS 2986
Query: 667 QLKKMATKARSRKLSPTPP 685
Q K ++ S L P P
Sbjct: 2987 QQSKQDSRG-SPLLGPVVP 3004
Score = 44.4 bits (100), Expect = 0.004
Identities = 53/261 (20%), Positives = 112/261 (42%), Gaps = 19/261 (7%)
Query: 154 QTQLAITKND--SLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYK-- 209
+ +L +TK D S E+V KM +T+ E +K E + +++ +
Sbjct: 2690 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2749
Query: 210 -DERSSTKDDVNFLM----QVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXX----XX 260
+E S+KD + L ++K S + + + G
Sbjct: 2750 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2809
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
L+D+N K+Y+ +I+ ++++ ++ C +K + D+L ++ + K TT E+
Sbjct: 2810 LLDTN-KQYEVEIQTYREKLTS-KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK 2867
Query: 321 KLQQK----VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
K + VN+L NE + + K L + +++E E E +Q + ++ +
Sbjct: 2868 KTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV 2927
Query: 377 AETLCEELMDENEDMKKELRD 397
+T +EL E +++K+ L +
Sbjct: 2928 MDTKVDELTTEIKELKETLEE 2948
Score = 43.6 bits (98), Expect = 0.007
Identities = 111/584 (19%), Positives = 223/584 (38%), Gaps = 37/584 (6%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLED 784
++++E+LEQ+ + K ++ E + + + S T ++ TT ED
Sbjct: 108 KKQIEKLEQELKRCKSEL-ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYED 166
Query: 785 EIDEVRKKLIEKER---DCERLHAELSLAQKKPKTLIKSRSL---DASDQ----QNVDLK 834
++ K++ E++R + + L A+ + +Q P+ + R + AS Q
Sbjct: 167 LKEKYNKEVEERKRLEAEVKALQAKKA-SQTLPQATMNHRDIARHQASSSVFSWQQEKTP 225
Query: 835 RQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
L Q + R + S + ++ LQ+ K + S + QL+
Sbjct: 226 SHLSSNSQRTPIRRDFSASYFSGELEVTPSRSTLQIGKRDAN-SSFFGNSSSPHLLDQLK 284
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK-QXXXXXXXXXXXXXXXX 953
+ +E KI ELE+ Q + E K + + + + K+K +
Sbjct: 285 AQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELV 344
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE-DLECEIGEMYVVMKNAGL 1012
Q S K A + ++ K DL+ + Q + LE +I E + L
Sbjct: 345 RTTAQYDQASTKYTA---LEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEE-L 400
Query: 1013 SGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANK 1072
S ++ + +T L++E +++++L++ + N N LQ E+ KL V +LE + + F K
Sbjct: 401 SRQQRSFQT-LDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQK 459
Query: 1073 YKALEN--ENSNL-SNQCKTLTEEMKNREAQINKLSAD-LKNATSLQTTMSDCMXXXXXX 1128
E + S + N+ + EEMK + S + L+ + +
Sbjct: 460 LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQS 519
Query: 1129 XXXXXXXXXXXXXXXXQV-DNYTKIDQDKNKLLKEVGDKTK-KIGDXXXXXXXXXXXCKR 1186
+ D KI+Q +N L E K K + D K+
Sbjct: 520 QNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE---KLKLAVADLEKQRDCSQDLLKK 576
Query: 1187 IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFIT 1246
E + D+++ +A++ A ++ E E+ L + + K +T
Sbjct: 577 REHHIEQLNDKLS-----KTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLT 631
Query: 1247 LEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK 1290
+M K + ++KI LE+ + + + + + +R D+
Sbjct: 632 ---QMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDR 672
Score = 41.5 bits (93), Expect = 0.030
Identities = 109/556 (19%), Positives = 219/556 (39%), Gaps = 41/556 (7%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
++ + V + +E KQ L+K+CE + + K +I + + S +
Sbjct: 827 ILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS 886
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
KLQ+ + + H + + L K +E++ L + TE Q E ++ L ++L
Sbjct: 887 KLQE---DTSAHQNVVAETLSALENKEKELQL-LNDKVETE-QAEIQELKKSNHLLEDSL 941
Query: 381 CE-ELMDENEDM-KKELRDLXXXXXXMQDNFREDQA---DEYSSLRRELEQTIKNCRVLS 435
E +L+ E + KKE+ + + ++ + +SL +E I+ +
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
Query: 436 FKLKKTERK----ADQLEQEKAEHEKKLLEIVGGPDGMQR-----ENRIKELEQEVARST 486
+ + E+ +DQ +QEK ++ E + + + + + +LE + T
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL 546
+ + EL + F + + + L Q+ + D Q++
Sbjct: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS 1121
Query: 547 EREA-DLREQLRNAEEETANC-KQVNPPTFLDKQVM--TDNIVTCDIHESETVTNSIQNK 602
+ EA L++++ +EE K+VN ++Q+M C ESE + NS++ +
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKER 1181
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
S + + + P +D +E L M N K E++ E
Sbjct: 1182 -------ESERNQCNFKP-QMDLEVKEISLDSYNAQLVQLEAMLRNKELK-LQESEKEKE 1232
Query: 663 SLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT 722
L +L+ + + L + ++S + D +E + P E+ N
Sbjct: 1233 CLQHELQTIRGDLETSNLQDM-QSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQC 1291
Query: 723 VLR---RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERV 779
L+ K+ ELE+ E L+ + EL ++++ S TA R + KL E V
Sbjct: 1292 SLQTTMNKLNELEKICEILQAEKYELVTELND----SRSECITATRKMAEEVGKLLNE-V 1346
Query: 780 KVLEDEIDEVRKKLIE 795
K+L D+ + +L+E
Sbjct: 1347 KILNDDSGLLHGELVE 1362
Score = 39.1 bits (87), Expect = 0.16
Identities = 37/167 (22%), Positives = 72/167 (43%), Gaps = 12/167 (7%)
Query: 1617 QSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIK 1676
Q+ + ++ E+ + + + N ++ + +V E N KQ L +Q E+K
Sbjct: 468 QASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK 527
Query: 1677 NGDKSARIHRNSI--------SSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
+ S + +S E+ + VA LE+Q C +D L + +LN +
Sbjct: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
Query: 1729 LVSEKSSAEVRLAEMQSRLNEY----EEERLLSSGRARVAGLATRME 1771
L + ++ L+ ++ + EY EE+ L S ++ L T+ME
Sbjct: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME 634
Score = 39.1 bits (87), Expect = 0.16
Identities = 85/406 (20%), Positives = 168/406 (41%), Gaps = 48/406 (11%)
Query: 1376 KAKELDTDLQSERKK-LDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK 1434
K KE +L+S + + L +++A + +VK K L TL + L ++ T L
Sbjct: 2079 KMKEKTQELESHQSECLHCIQVA-EAEVKEKTELLQTLSSDVSELLKDK-------THL- 2129
Query: 1435 QEYEETVKKLEHSLALEKAEYE----ELTGKYELLEEEHVVTKARLTVEKEQAQGELLHV 1490
QE ++++K +L+L K E E +L + ELL +E +ARL+ ++ E L+V
Sbjct: 2130 QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLS----ESDYEKLNV 2185
Query: 1491 QKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD 1550
K L AL E + + ++ E +++ I L+ R+ E ++ + +L
Sbjct: 2186 SKALEAALVE----KGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD--EKKQLHIAEKLK 2239
Query: 1551 QRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXX 1610
+RERE + D+ + LE + + + Q
Sbjct: 2240 ERERENDSLKDKVENLER-----------------ELQMSEENQELVILDAENSKAEVET 2282
Query: 1611 XXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
IE+ ++ K D T + + +++ Q+S + ++K +LE ++
Sbjct: 2283 LKTQIEEMARSLKVFELDLVT-LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ 2341
Query: 1671 SMAEIKNGDKSA-RIHRNSISSTDE--EEYRNKVALLEQQVACLEDELCESRLLASKLNT 1727
+ +IK K+A + +N + +E +++ L+ + E L + +
Sbjct: 2342 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2401
Query: 1728 ELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA 1773
++ + +L +Q +L E E L G RV L +E+A
Sbjct: 2402 LRARLEADEKKQLCVLQ-QLKESEHHADLLKG--RVENLERELEIA 2444
Score = 38.3 bits (85), Expect = 0.28
Identities = 61/305 (20%), Positives = 126/305 (41%), Gaps = 29/305 (9%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYE---NKITSLESTIAAKDVHIKQL-- 1279
+LT + ++L+ + ++ + + +DL A+YE + + S ++++ + H + L
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786
Query: 1280 ---EDALRQT-TNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
+ A+ + N ++ + P E E R Q+ +++ + LE + +
Sbjct: 787 FDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMN 846
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD---------LQS 1386
S + + +L ++E +S +K +E DT L +
Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE-DTSAHQNVVAETLSA 905
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
K +++ +DK V+ + AE+ LK +LE + K + L + K++
Sbjct: 906 LENKEKELQLLNDK-VETEQAEIQELKKSNHLLEDS----LKELQLLSETLSLEKKEMSS 960
Query: 1447 SLALEKAEYEELTGKYELLEEEHV---VTKARLTVEKEQAQGELLHVQKELSTALGEIKT 1503
++L K E EELT + L+E + K L + E + +K +S + K
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYK- 1019
Query: 1504 LQEKL 1508
QEKL
Sbjct: 1020 -QEKL 1023
Score = 37.5 bits (83), Expect = 0.48
Identities = 65/342 (19%), Positives = 134/342 (39%), Gaps = 14/342 (4%)
Query: 1228 SEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTT 1287
S+ ++L+ ++ K + LEAE++ L+A ++ T ++T+ +D+ Q ++
Sbjct: 162 SKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQ-TLPQATMNHRDIARHQASSSVFSWQ 220
Query: 1288 NDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS-----AAKLEM 1342
+K S + + + +++ K +A SS ++ +
Sbjct: 221 QEKTPSHLSSNSQRTPIRRDFSASYFSGELEVTPSRSTLQIGKRDANSSFFGNSSSPHLL 280
Query: 1343 AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK-- 1400
QLK+ +L N NK +EL L+ + +L +K
Sbjct: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCR 340
Query: 1401 -DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELT 1459
++ A+ K LEQ + ++ +Q E LE + ++ E++E
Sbjct: 341 DELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEEL 400
Query: 1460 GK----YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT-ESAA 1514
+ ++ L++E + KARLT E +QA+ +Q EL + L+ L +
Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL 460
Query: 1515 WNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQREREL 1556
E+ + I + R + E L + +Q+ RE+
Sbjct: 461 CRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREV 502
Score = 36.3 bits (80), Expect = 1.1
Identities = 59/315 (18%), Positives = 117/315 (37%), Gaps = 19/315 (6%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
L ++ ++ E Q + + F TL+ E +KA ++ ++ + +L
Sbjct: 385 LEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTS 444
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL- 1340
+Q N+ +E + E E + L K+ +E A ++
Sbjct: 445 VKQQLENN-LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
Query: 1341 ----EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
E+ +K L + +N + K + + L E+ KL +
Sbjct: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
Query: 1397 AHDKD-----VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALE 1451
+D +K ++ + L KL E+ S A + K+EYEE +K+ + +
Sbjct: 564 EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE-LKEEKTLFSCW 622
Query: 1452 KAEYEELTGKYELLEE------EHVVTKARLTVEKEQAQGELLH-VQKELSTALGEIKTL 1504
K+E E+L + E +E H+ T + K E + ++ + EI+ L
Sbjct: 623 KSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNL 682
Query: 1505 QEKLGTESAAWNTEK 1519
L ++S T+K
Sbjct: 683 HNVLDSKSVEVETQK 697
>X75304-1|CAA53052.1| 3259|Homo sapiens giantin protein.
Length = 3259
Score = 82.6 bits (195), Expect = 1e-14
Identities = 266/1485 (17%), Positives = 588/1485 (39%), Gaps = 121/1485 (8%)
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAAETLCEEL 384
V ++ +++ EK L K+ SEL + Q + QI + ++ + +T+ E
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
E ++++L ++ + RE Q + L++ + + ++ LS +L + E
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLE-HLRELQP-KLDELQKLISKKEEDVSYLSGQLSEKEAA 1421
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
+++ E E E + + Q E + KE ++ + + +V L ++ E + +
Sbjct: 1422 LTKIQTEIIEQEDLIKAL-----HTQLEMQAKEHDERI-KQLQVELCEMKQKPEEIGEES 1475
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQL--RNAEE 561
+ + + Q + + +L S ++ L R + L + AD+ Q+ +N E+
Sbjct: 1476 RAKQQIQRKLQAALIS-RKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534
Query: 562 ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK--SDSP 619
+T + DK ++T+ + + E++++++S ++ + KEK +
Sbjct: 1535 DTVLGRLALLQEERDK-LITE--MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIE 1591
Query: 620 PLSIDKTTEETQF---HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
L K E T++ H +L + N+ A R++ E++ + +++ K R
Sbjct: 1592 SLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR 1651
Query: 677 SRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE 736
S + ANK ET EK+ EA+ EM+ + E + A ++K+ ELE++ +
Sbjct: 1652 STE------ANKK--ET-----EKQLQEAEQ-EMEEMKEKMRKFAKSKQQKILELEEEND 1697
Query: 737 ALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEK 796
L+ +V +T SN + + L ERVK+ E + + KK
Sbjct: 1698 RLRAEVHPAGDTAKECMETLLSSNASMKEEL---------ERVKM---EYETLSKKFQSL 1745
Query: 797 ERDCERLHAEL-SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLE 855
+ + L E+ L + + K +L+A+++ + Q V E+ + +T+ E
Sbjct: 1746 MSEKDSLSEEVQDLKHQIEDNVSKQANLEATEKHD----NQTNVTEEGTQSIPGETE--E 1799
Query: 856 ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEK 915
D+ + T + + +AKS ++ A+ + ++ N L++ + ++KE ++EK
Sbjct: 1800 QDSLSMSTRPTCSESVPSAKS--ANPAVSKDFSSHDEINNYLQQ-IDQLKERIAGLEEEK 1856
Query: 916 SEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
+ K F++ + E +TL S+ ++ K K
Sbjct: 1857 QKNK-EFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK-LKET 1914
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLS 1035
++ DL +L + +L IG + +A + + + ++ K + + S+L
Sbjct: 1915 AEEEKDDLEERLM--NQLAELNGSIGNYCQDVTDAQIKNELLESEM---KNLKKCVSELE 1969
Query: 1036 KNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+ + EK ++++EI K+ K++G + NK A E + L + + + + K
Sbjct: 1970 EEKQQLVKEKTKVESEIR--KEYLEKIQGAQKEPGNKSHAKELQEL-LKEKQQEVKQLQK 2026
Query: 1096 NREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQ 1154
+ K+SA + +L+ ++ ++ ++ +D
Sbjct: 2027 DCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD 2086
Query: 1155 DKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVV 1214
+++ + + D K + K+ ++ L R ++ + +
Sbjct: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL- 2145
Query: 1215 LANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAA 1271
+ RR + L E+Q K + + L+ + A + ++SL+
Sbjct: 2146 --DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDR 2203
Query: 1272 KDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT 1331
K+ E K +E + + + ++N ++++ +K
Sbjct: 2204 VIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV-LKDQLRQMSIHMEELKINISRLEHDKQ 2262
Query: 1332 EAESSA-AKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
ES A ++++ Q D + EN SS +N+ +L+++L+S + +
Sbjct: 2263 IWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS--QNELAKLESELKSLKDQ 2320
Query: 1391 LDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI-TELKQEYEETVKKLEHSLA 1449
L + + +K K + L + + + QNS +++ T+L+ E T + E
Sbjct: 2321 LTDLSNSLEK-CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
Query: 1450 LEKAEYEELTGKYEL-------LEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIK 1502
E+ L+GK E L ++H L Q + E + +++E A+ +
Sbjct: 2380 KEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN 2439
Query: 1503 TLQEKLGT---ESAAWNTEKTEMQNSIASLQ---ERLCGGGWEVERARLNARL--DQRER 1554
L E L T E+ + S++SLQ +R+ G ++E L+ L DQ +
Sbjct: 2440 QLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQ 2499
Query: 1555 ELRAANDR-----RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXX 1609
E A N++ R + H D E ++++
Sbjct: 2500 EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQL 2559
Query: 1610 XXXXXIEQSEKARKAEITDTKTRYEG---QMNTMRDELKSLHNQVSRFRRERDNYKQMLE 1666
+E + ++ +++ E N +++E + L ++ + + +
Sbjct: 2560 QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT 2619
Query: 1667 AAQK----SMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES-RLL 1721
A Q+ + + K +HR S + ++ ++A LE+++ C++ E + +
Sbjct: 2620 ALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK---RIAELEEELVCVQKEAAKKVGEI 2676
Query: 1722 ASKLNTELV----------SEKSSAEVRLAEMQSRLNEYEEERLL 1756
KL EL +E +AE R+AE+ L E E++ L+
Sbjct: 2677 EDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721
Score = 76.6 bits (180), Expect = 9e-13
Identities = 290/1528 (18%), Positives = 612/1528 (40%), Gaps = 141/1528 (9%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAK---LLAAE 378
++QK +L +E L++E+K KI++++ L + + + IE+++A+ +L E
Sbjct: 68 IRQKDVQLQQKDEALQEERKAADNKIKKLK--LHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
Query: 379 TLCEELMDEN-----------EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQT 427
EE + ++ E +K +L++ +Q + QA++ + E+E+
Sbjct: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEF 185
Query: 428 IKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG-MQRENRIKELE-QEVARS 485
+ + L K + QL Q +AE + ++V D + + R+ E E ++
Sbjct: 186 VMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ--QVVREKDARFETQVRLHEDELLQLVTQ 243
Query: 486 TEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
+V +Q++L K SL V + + V + + LT + E Q+L
Sbjct: 244 ADVETEMQQKLRVLQRKLEEHEESL--VGRAQVVDLLQQELT---AAEQRNQILSQQLQQ 298
Query: 546 LEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH---ESETVTNSIQN 601
+E E + LR + EE+ + ++++ N+ ++H E Q
Sbjct: 299 MEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQE-EMHHLLEQFEQAGQAQA 357
Query: 602 KMIHAASTPSSKEKSD-----SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR--KTA 654
++ S K K++ S LS+ KT +E Q D + N + ++A
Sbjct: 358 ELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSA 417
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSI-ETANDNDEKETDEADPAEMKLL 713
+++ + L + K+++ L A++ S + N+ + T+E + K +
Sbjct: 418 QTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRV 477
Query: 714 LEL-NEQEATVLRR-KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNS 771
+EL NE+ A +L ++EEL+ + E L Q+ L ++ +T + S+ +
Sbjct: 478 VELENEKGALLLSSIELEELKAENEKLSSQITLLEAQ----NRTGEADREVSEISIVDIA 533
Query: 772 NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKK---PKTLIKSRSLDASDQ 828
NK + + +D ++ +K ++ L E+ AQ++ K ++ + + +D
Sbjct: 534 NKRSSSAEESGQDVLENT---FSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADH 590
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
+ +D K Q+ + + ++ K + + N++ L ++ ++A +
Sbjct: 591 EVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSL----PAVEKEQASTEHQS 646
Query: 889 KTTQLENELKEALAKIKELEMICQDEKSEKKV-RFTEATKKETDTLKSKQXXXXXXXXXX 947
+T++ E L +A ++K + +KS V + + E + LKS+
Sbjct: 647 RTSE-EISLNDAGVELKSTKQ--DGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKA 703
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVM 1007
+A S + + FK + T L + + L ++ E+ +V
Sbjct: 704 QEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTA---LSEERDQLLSQVKELSMVT 760
Query: 1008 K-NAGLSGKEMT-AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
+ A + EM A+ + ++ +D + +D+ T + + L E AK KDV K+E
Sbjct: 761 ELRAQVKQLEMNLAEAERQRRLD--YESQTAHDNLLTEQIHSLSIE-AKSKDV--KIE-- 813
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXX 1125
V N+ ++ + S S ++L +++N+E+++ + + +++ +S +S +
Sbjct: 814 --VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQAL--- 868
Query: 1126 XXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVG-DKTKKIGDXXXXXXXXXXXC 1184
V+ + ++K++ + E+ T+K+
Sbjct: 869 SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARF--IKTES 1242
K +++QL+ + L + +S K+ELQ F +K E+
Sbjct: 929 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988
Query: 1243 KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMV 1301
E R L+A N+ L+ + +LE+ L ++ K + S E
Sbjct: 989 -----EQRKRKLQAALINRKELLQ--------RVSRLEEELANLKDESKKEIPLSETERG 1035
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXX 1361
E+ + +I L++T +E ++E+ ++ D LE
Sbjct: 1036 EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEK---EVELQHIRKD---LEEKLAAEEQ 1089
Query: 1362 XXXXXXXXSSYWENKAKELDTDLQ---SERKKLDRMRIAHDKDVKNKDAELATLKGKLKI 1418
+ ++K ++D LQ SE + + + I + D + D+ +A +K + I
Sbjct: 1090 FQALVKQMNQTLQDKTNQIDL-LQAEISENQAIIQKLITSNTDASDGDS-VALVKETVVI 1147
Query: 1419 LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
+G+ K E EE + LALEK E E+L K L+E KA L
Sbjct: 1148 SPPCTGSS----EHWKPELEEKI------LALEK-EKEQLQKK---LQEALTSRKAIL-- 1191
Query: 1479 EKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGW 1538
++AQ + H+++EL + LQE+ +S +++ ++E + G
Sbjct: 1192 --KKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLP 1249
Query: 1539 EVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQ-RXX 1597
++ + E L A E HH E S +Q
Sbjct: 1250 STDQQESCSSTPGLEEPLFKAT------EQHHTQPVLESNLCPDWPSHSEDASALQGGTS 1303
Query: 1598 XXXXXXXXXXXXXXXXXIEQSEKARKAEIT---DTKTRYEGQMNTMRDELKSLHNQVSRF 1654
+E + +E+T + + + Q+N E++SL
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363
Query: 1655 RRERDNYKQMLEAAQKSMAEIKN-GDKSARIH--RNSISSTDEEEYRNKVALLEQQVAC- 1710
++ +Q LE++Q +A +++ + ++ + IS +E+ L E++ A
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALT 1423
Query: 1711 -LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEE--ERLLSSGRARVAGLA 1767
++ E+ E L L+T+L + + R+ ++Q L E ++ E + RA+ +
Sbjct: 1424 KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK-QQIQ 1482
Query: 1768 TRMELAW--HKERDEQQRLLQETSTLAR 1793
+++ A KE ++ + LQE +LAR
Sbjct: 1483 RKLQAALISRKEALKENKSLQEELSLAR 1510
Score = 74.5 bits (175), Expect = 3e-12
Identities = 163/870 (18%), Positives = 355/870 (40%), Gaps = 99/870 (11%)
Query: 271 DQIEGLKQEVDILRKRCERV--EKEKSDILLRRLAN-IDTANKYTTGRSSEVLKLQQKVN 327
D+I Q++D L++R + EK+K+ + L N +T + + E+ LQ++V
Sbjct: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD- 386
++ N+ +++E +T K++E E E E Q+ +L + C+++ D
Sbjct: 1893 KMNLLNQQIQEELSRVT-KLKETAEE-EKDDLEERLMNQLAELNGSI---GNYCQDVTDA 1947
Query: 387 --ENEDMKKELRDLXXXXXXMQDNFRE---DQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+NE ++ E+++L +++ ++ ++ S +R+E + I+ + K
Sbjct: 1948 QIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGN-KSH 2006
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
++ +L +EK + K+L + D ++ + +I LE+ V V Q++L E
Sbjct: 2007 AKELQELLKEKQQEVKQLQK-----DCIRYQEKISALERTVKALEFVQTESQKDL-EITK 2060
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD---LQDSLE-READLREQLR 557
+ K Q E ++ + +Q + A++L D L+ L+ + ++ Q++
Sbjct: 2061 ENLAQAVEHRKKAQAE---LASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMK 2117
Query: 558 NAEEE-TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKS 616
+E+ +Q +K+ M + + ++++ + +H T + +
Sbjct: 2118 QKDEDLERRLEQAEEKHLKEKKNMQEKL------------DALRREKVHLEETIGEIQVT 2165
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
+ DK ++ Q + D S +AA K+ + +++D + ++ + KK
Sbjct: 2166 LNKK---DKEVQQLQENLD----STVTQLAA--FTKSMSSLQDDRDRVIDEAKKW----- 2211
Query: 677 SRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE 736
RK S + + I DN D+ +M + +E L+ + LE DK+
Sbjct: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQL--RQMSIHME-------ELKINISRLEHDKQ 2262
Query: 737 ALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEK 796
+ + + V T G N K L +++E R
Sbjct: 2263 IWESKAQTEVQLQQKVCDTLQGEN-------------------KELLSQLEETRHLYHSS 2303
Query: 797 ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+ + +L +EL + + L S SL+ +Q +L+ ++ +QEA + +K S E
Sbjct: 2304 QNELAKLESELKSLKDQLTDL--SNSLEKCKEQKGNLEGIIR--QQEADIQNSKF-SYEQ 2358
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE---NELKEALAK-IKELEMICQ 912
LQ + L +++ K + L + K ++ EL++ K IKELE +
Sbjct: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
Query: 913 DEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSF 972
E+ E+ + E KK D ++ SL++D +
Sbjct: 2419 QEE-EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV 2477
Query: 973 KPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIR 1031
+ L+ L+ +++++ E ++ ++ ++ ++ KL+ E+ + R
Sbjct: 2478 GDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYR 2537
Query: 1032 SKLSKNDS-EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTL 1090
L++ + + + +K L+ ++ + N +LE K K E N +L L
Sbjct: 2538 EDLNQVITIKDSQQKQLLEVQLQQ----NKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
Query: 1091 TEEMKNREAQINKLSADLKNATSLQTTMSD 1120
EE ++ +I L + T T + +
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQE 2623
Score = 71.3 bits (167), Expect = 3e-11
Identities = 295/1539 (19%), Positives = 588/1539 (38%), Gaps = 158/1539 (10%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEV---- 319
S++ Q + L+ D L+ + ++ ++K++ ++ I +S E+
Sbjct: 379 SHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFL 438
Query: 320 --LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
L LQQ T D+ +E TQ + E E S + + ++E + LL +
Sbjct: 439 NRLPLQQHETASQTSFPDVYNEG---TQAVTE-----ENIASLQKRVVELENEKGALLLS 490
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
EEL ENE + ++ ++ R +AD S ++ I N R S +
Sbjct: 491 SIELEELKAENEKLSSQI-------TLLEAQNRTGEADREVSEISIVD--IANKRSSSAE 541
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL--QRE 495
E D LE ++ K+L ++ Q E +L+ + R+ E + Q+E
Sbjct: 542 ----ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKE 597
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
+ + + G P MKV +T + ++E + Q S E ++ E+
Sbjct: 598 MKQMEGE--GIAPIKMKVFLEDTGQ----DFPLMPNEESSLPAVEKEQASTEHQSRTSEE 651
Query: 556 --LRNAEEETANCKQVNPPTFLDKQVMT-DNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
L +A E + KQ DK + +I C E E + + I ++
Sbjct: 652 ISLNDAGVELKSTKQDG-----DKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
EK+ +D+ +E L + F A NN A + E+ + LL Q+K+++
Sbjct: 707 YEKN------LDEKAKEISNLNQL--IEEFKKNADNNSSAFTA-LSEERDQLLSQVKELS 757
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQ---EATVLRRKV 728
R +L + A ++ D E+ A LL E EA K+
Sbjct: 758 MVTELRA-----QVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKI 812
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE--ERVKVLEDEI 786
E L+ + + ++ Q E ++ I S+ + L +++ E ERV+ + ++
Sbjct: 813 EVLQNELDDVQLQFSEQSTLIRSL-----------QSQLQNKESEVLEGAERVRHISSKV 861
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+E+ + L +KE + ++ L ++ +TL QQ ++ K Q QV E S+
Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDVETL----------QQTIEEKDQ-QVTEISFSM 910
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
Q L + L E K L+ N S R+++A ++ ++ + LK+ E
Sbjct: 911 TEKMVQ-LNEEKFSLGVEIKTLKEQLNLLS-RAEEAKKEQVEEDNEVSSGLKQ---NYDE 965
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
+ Q K E + F + KKE + K K + L +LKD
Sbjct: 966 MSPAGQISKEELQHEF-DLLKKENEQRKRK---LQAALINRKELLQRVSRLEEELANLKD 1021
Query: 967 DAQKSFKPRIPKK---PTDLTTKLQLKKMVEDLECEIGEMYVVM----KNAGLSG--KEM 1017
+++K ++ D K +K V +C+ E+Y+ K L K++
Sbjct: 1022 ESKKEIPLSETERGEVEEDKENKEYSEKCVTS-KCQEIEIYLKQTISEKEVELQHIRKDL 1080
Query: 1018 TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL-EGDKDVFANKYKAL 1076
K E++ + ++++ + TN+ + LQ EI++ + + KL + D AL
Sbjct: 1081 EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXX 1136
E +S C +E K + K+ A K LQ + + +
Sbjct: 1141 VKETVVISPPCTGSSEHWKPELEE--KILALEKEKEQLQKKLQEALTSRKAILKKAQEKE 1198
Query: 1137 XXXXXXXXQV-DNYTKIDQDKNKLLKE---VGDKTKKIGDXXXXXXXXXXXCKRIEKQLS 1192
Q D+Y ++ + ++ KE +GD+ +++ ++ S
Sbjct: 1199 RHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCS 1258
Query: 1193 TRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMR 1252
+ Q V+ +N L + S ++ A ++ + ++A+++
Sbjct: 1259 STPGLEEPLFKATEQHHTQPVLESN----LCPDWPSHSEDASA--LQGGTSVAQIKAQLK 1312
Query: 1253 DLKAD---YENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
+++A+ E K++S S + K + QL++ + + +E+ ++
Sbjct: 1313 EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK----------QGLEIESLKTVSHE 1362
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
Q +L ++++++ E + ++ +L+ ++K E
Sbjct: 1363 AEVHAESLQQKLESSQLQIAGLE-HLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAA 1421
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
+ + + E + +++ +L+ HD+ +K EL +K K + + + S A
Sbjct: 1422 LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA---- 1477
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLH 1489
KQ+ + +KL+ +L K +E E L T RLT + ++
Sbjct: 1478 ----KQQIQ---RKLQAALISRKEALKENKSLQEELSLARG-TIERLTKSLADVESQVSA 1529
Query: 1490 VQKELSTALGEIKTLQE---KLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER--AR 1544
KE T LG + LQE KL TE E + +S SL+ L G + E+
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1589
Query: 1545 LNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXX 1604
+ + + E ++ L+ ++ + V + R
Sbjct: 1590 IESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK 1649
Query: 1605 XXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRE----RDN 1660
E+ + + E+ + K + + + ++ L + R R E D
Sbjct: 1650 LRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDT 1709
Query: 1661 YKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRL 1720
K+ +E S A +K + ++ ++S + K +L E +V L+ ++ ++
Sbjct: 1710 AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE-EVQDLKHQIEDN-- 1766
Query: 1721 LASKLNTELVSEKSSAEVRLAE--MQSRLNEYEEERLLS 1757
++ + N E +EK + + E QS E EE+ LS
Sbjct: 1767 VSKQANLE-ATEKHDNQTNVTEEGTQSIPGETEEQDSLS 1804
Score = 62.5 bits (145), Expect = 1e-08
Identities = 122/698 (17%), Positives = 291/698 (41%), Gaps = 51/698 (7%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI--LLRRLANIDTANKYTTGRSSEVL- 320
S+ KE Q+ ++ +QEV L+K C R +++ S + ++ L + T ++ + E L
Sbjct: 2005 SHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLA 2064
Query: 321 -------KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELET-RPSTEAQTRQ-IEQLR 371
K Q ++ +D + E + +++ EL++ + S ++Q +Q E L
Sbjct: 2065 QAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
Query: 372 AKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQA------DEYSSLRRELE 425
+L AE E+ + E ++M+++L L +++ E Q E L+ L+
Sbjct: 2125 RRLEQAE---EKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181
Query: 426 QTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARS 485
T+ + + + D++ E + E+K + + + E R+KE V +
Sbjct: 2182 STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAI---QSKEEEIRLKEDNCSVLKD 2238
Query: 486 TEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
+ + E + N + + + V++ + Q + +LL L+++
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT--LQGENKELLSQLEET 2296
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
+ +L E E + K D +++++ C + + I+ +
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKD----QLTD---LSNSLEKCK-EQKGNLEGIIRQQEAD 2348
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEEDNES 663
++ S E+ ++ + + T ++ I + ++ ++ A + + ++
Sbjct: 2349 IQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDK 2408
Query: 664 LLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK-ETDEADPAEMKLLLELNEQEAT 722
+ +L+ + ++ + NK +++ N E +T + + + K L+ + +
Sbjct: 2409 EIKELENLLSQEEEENI-VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMS 2467
Query: 723 VLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR---RSLTTNSNKLAEERV 779
L+ + + D + L+++ + + + + +A N + R L ++ + L E
Sbjct: 2468 SLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENA 2527
Query: 780 KVLEDEIDEVRKKL---IEKERDCERLHAELSLAQKKP---KTLIKSRSLDASDQQNVDL 833
K L+ E+ + R+ L I + ++ E+ L Q K K L S++ N DL
Sbjct: 2528 K-LDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDL 2586
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD-KALDLNTKKTTQ 892
+R +++E L + +SL+ +L + LQ + K + + +
Sbjct: 2587 RRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSA 2646
Query: 893 LENELKEALAKIKELEMICQDEKSEKKV-RFTEATKKE 929
L + ++ +A+++E E++C +++ KKV + KKE
Sbjct: 2647 LFSSSQKRIAELEE-ELVCVQKEAAKKVGEIEDKLKKE 2683
Score = 55.2 bits (127), Expect = 2e-06
Identities = 144/798 (18%), Positives = 313/798 (39%), Gaps = 63/798 (7%)
Query: 188 EKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXX 247
+KE + S+E+E+ ++E D N LM+ + N++ +
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ----LDSF 2462
Query: 248 XXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDT 307
+V + + + + ++ ++++ K K +I R +++D
Sbjct: 2463 VKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLR-SHMDD 2521
Query: 308 ANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETR-PSTEAQTRQ 366
N +E+++ ++ +N++ T + ++K L + + ELE + E + ++
Sbjct: 2522 LNSENAKLDAELIQYREDLNQVITIKD---SQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
Query: 367 IEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSL-RRELE 425
E+ L + L +E +D+ KE+ L + Q + L +L+
Sbjct: 2579 SEEANEDLRRS---FNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLK 2635
Query: 426 QTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG-PDGMQRENRIKELEQEVAR 484
+ LS ++++ +LE+E +K+ + VG D +++E + + + R
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR 2695
Query: 485 S-TEVA----LRLQRELAEANSKF---TGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA 536
+ TE A L R+L E K T N L Q +S +R + E+
Sbjct: 2696 NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELD 2755
Query: 537 QLLRDLQDSLEREADLREQ-LRNAE-----EETA---NCKQVNPPTFLDKQVMTDNIVTC 587
+L R SL+ A L+EQ L N E ETA N + N + L+K + +++
Sbjct: 2756 ELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEK--LNQQLLSK 2813
Query: 588 D---IHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNH 644
D +H S + +S + + S + + D ++K + + +
Sbjct: 2814 DEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSP 2873
Query: 645 MAANNLRKTAARVEEDNESLLLQLKKM---------------ATKARSRKLSPTPPANKL 689
+L+K + ++ D + LL +LK + KA+ ++ A ++
Sbjct: 2874 AEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQI 2933
Query: 690 SIETANDNDEKETDEADPAEM-KLLLELNEQE-ATVLRRKVEELEQDKEALKKQVKELTS 747
E + E M K E++E+ + + +Q L+ ++EL S
Sbjct: 2934 MQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRS 2993
Query: 748 KISSV--TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHA 805
S K + S + + ++ ++L ++++ K++ +KE ++L++
Sbjct: 2994 SSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNS 3053
Query: 806 ELSLAQKKPKTLI-----KSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK 860
S ++ TL S+SL + Q DL V+E++ L+A +++
Sbjct: 3054 NFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGA 3113
Query: 861 LQTEN---KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE 917
Q +N +K + + +S T Q NEL++ L + ++ + ++ S
Sbjct: 3114 PQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSV 3173
Query: 918 KKVRFTEATKKETDTLKS 935
+ + E D+ ++
Sbjct: 3174 AEEQIRRLEHSEWDSSRT 3191
Score = 50.8 bits (116), Expect = 5e-05
Identities = 104/597 (17%), Positives = 246/597 (41%), Gaps = 52/597 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR------RLANIDTANKYTTGRSSEVL 320
+++ D I+ ++E+ + C ++ + + + ++ ++ + ++ +
Sbjct: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV 2272
Query: 321 KLQQKV-NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
+LQQKV + L N++L + + ++EL E++ + ++ L +
Sbjct: 2273 QLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA---KLESELKSLKDQLTDLSNSLE 2329
Query: 380 LCEELMDENEDM-KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
C+E E + +++ D+ + + QA + R E +K +++S
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLS 2389
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVA-RSTEVALRLQRELA 497
K E + + + +H+K++ E+ + EN + E E + A T + + +
Sbjct: 2390 GKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK 2449
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLEREA-----D 551
+ N + S +K +++ R + Q + L L+ D L +EA
Sbjct: 2450 KENIQQKAQLDSFVK--SMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPS 611
L+E++R + N LD +++ D+++ T+ +S Q K +
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAK--LDAELIQ---YREDLNQVITIKDS-QQKQLLEVQLQQ 2561
Query: 612 SKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKM 671
+KE + +K E + + DL + N L++ + ++ ESL + + ++
Sbjct: 2562 NKELENKYAKLEEKLKESEEANEDL-------RRSFNALQEEKQDLSKEIESLKVSISQL 2614
Query: 672 ATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEEL 731
+ + + T ++ + + + K + EL E+ V + +++
Sbjct: 2615 TRQVTALQEEGTLGLYHAQLK-VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
+ ++ LKK++K L AG + N + AEERV L ++ E+ +
Sbjct: 2674 GEIEDKLKKELKHL--------HHDAG--------IMRNETETAEERVAELARDLVEMEQ 2717
Query: 792 KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
KL+ ++ + L A++ + +L SR D ++++ +LKR+ +E + L+
Sbjct: 2718 KLLMVTKENKGLTAQIQSFGRSMSSLQNSR--DHANEELDELKRKYDASLKELAQLK 2772
Score = 50.4 bits (115), Expect = 6e-05
Identities = 82/416 (19%), Positives = 173/416 (41%), Gaps = 40/416 (9%)
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
N+ +++ E +L++EL + ++R+K +L+Q EAL+++ K +KI +
Sbjct: 43 NNTTQEDVQERLAYAEQLVVELKD----IIRQKDVQLQQKDEALQEERKAADNKIKKLKL 98
Query: 755 TSAGSNTT---------ARRSLTTNSNKLAEERVK-------VLEDEIDEVRKKLIEKER 798
+ T+ A+ + +EE++ E EI++++ KL EKE
Sbjct: 99 HAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEE 158
Query: 799 DCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADN 858
L A+L+ AQ + + ++ V +K+QLQ E+ S L+A+ +A+
Sbjct: 159 LISTLQAQLTQAQAE-----QPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQ 213
Query: 859 EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEK 918
Q +K + L D+ L L T+ +E E+++ K++ L+ K E+
Sbjct: 214 AAQQVVREKDARFETQVRLHEDELLQLVTQ--ADVETEMQQ---KLRVLQ-----RKLEE 263
Query: 919 KVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPK 978
+ D L+ + TL++ + ++ K + K
Sbjct: 264 HEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEK 323
Query: 979 KPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKN 1037
++ + K +L+ E+ + + AG + E+ ++ + LE++ + + +
Sbjct: 324 MELEVAER---KLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Query: 1038 DSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA-NKYKALENENSNLSNQCKTLTE 1092
LQ+ LKD N+KL DK+ A + ++ L + K +++
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ 436
Score = 37.5 bits (83), Expect = 0.48
Identities = 45/240 (18%), Positives = 94/240 (39%), Gaps = 12/240 (5%)
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKY 1291
EL ++ E K + + E + L A ++ S+ S ++D ++L++ R+
Sbjct: 2707 ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLK 2766
Query: 1292 DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK 1351
+ A + + R N+ LEK + + ++ L S L
Sbjct: 2767 ELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLED 2826
Query: 1352 LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD-RMRIAHDKDVKNKDAELA 1410
N +N+ L +L+ RK + + R A AE+
Sbjct: 2827 SYNQVQSFSKAMASL-------QNERDHLWNELEKFRKSEEGKQRSAAQPSTS--PAEVQ 2877
Query: 1411 TLKGKLKILEQNSGAGAKRITELKQEYEETVKKLE--HSLALEKAEYEELTGKYELLEEE 1468
+LK + L+ + K + L+Q+Y + +++ H L + EY++ T +++++EE
Sbjct: 2878 SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEE 2937
>BC117209-1|AAI17210.1| 1438|Homo sapiens CLIP1 protein protein.
Length = 1438
Score = 82.6 bits (195), Expect = 1e-14
Identities = 183/897 (20%), Positives = 364/897 (40%), Gaps = 72/897 (8%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D E +Q+E K++V+ L+ R E K D+ + + D N T + + +L
Sbjct: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQISEDPENTQTKLEHARIKEL 480
Query: 323 QQ-------KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLR--A 372
+Q K ++L ED R +I E+E +L R A+ R++E +
Sbjct: 481 EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAG 540
Query: 373 KLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNF---REDQADEYSSLRRELEQTIK 429
+ + +L +E+ E ++ D ++++F E E +L E+ K
Sbjct: 541 DVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK 600
Query: 430 NCRVLSFKLKKTERK--------ADQLEQEKAEHEKKLLEI-VGGPDGMQREN-RIKELE 479
L KL+ ++ +LE A H++ + E+ V G+ E EL+
Sbjct: 601 ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELK 660
Query: 480 QEVARSTEVALRLQRELAEANSKFTGSNPS------LMKVPQPETVKVSRSSLTRGGSQE 533
++ + + L Q E+ ++ + ++ + +K +SL S+
Sbjct: 661 TQIEK---MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 717
Query: 534 DPA--QLLRDLQDSLEREADLREQLRNAEEETANC-KQVNPPTFLDKQVMTDNIVTCDIH 590
D A Q L +++D+L + + +++ E A C +Q Q+ D+
Sbjct: 718 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD 777
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL 650
++ +++M + EK L I+K E ++ L + NL
Sbjct: 778 ALRKASSEGKSEMKKLRQQLEAAEK-QIKHLEIEKNAESSKASSITRELQ-GRELKLTNL 835
Query: 651 RKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
++ + V + E+L +L+ + K + ET N +KE E
Sbjct: 836 QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ-ETVNKLHQKE--EQFNMLS 892
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L +L E A + K E ++ +E L K ++L + I+ + K S G N + LT
Sbjct: 893 SDLEKLRENLAD-MEAKFREKDEREEQLIKAKEKLENDIAEIMKMS-GDNPS---QLTKM 947
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
+++L R+K E +++E++ KL + + L + K + + + +++
Sbjct: 948 NDEL---RLK--ERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ-SQQEAAKKHEEEK 1001
Query: 831 VDLKRQLQVIEQEASVLRAKTQSLEADNEKL--QTENKKLQLLKNAKS--LRSDKALDLN 886
+L+R+L +E++ + Q L+A E+ +T+ K ++L+N + L ++ L
Sbjct: 1002 KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA 1061
Query: 887 TKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS----KQXXXXX 942
++ + L EL+E L K E Q + ++ + TK++T+TL S KQ
Sbjct: 1062 REENSGLLQELEE-LRKQAEKAKAAQTAEDAMQI-MEQMTKEKTETLASLEDTKQTNAKL 1119
Query: 943 XXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGE 1002
+ KS + ++ K +K + T K + + L E
Sbjct: 1120 QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIE-TLKQAAAQKSQQLSALQEE 1178
Query: 1003 MYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKL---SKNDSEFTNEKNRLQTEIAKLKDVN 1059
+ + G S E+T+ KLE+E + ++L K +S+F + + + + K +
Sbjct: 1179 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISIT 1238
Query: 1060 AKLEGDKDV----FANKYKALENENS---NLSNQCKTLTEEMKNREAQINKLSADLK 1109
+ L +KD N+ L EN+ +L + +TL + E ++ L LK
Sbjct: 1239 SALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 1295
Score = 77.0 bits (181), Expect = 6e-13
Identities = 220/1112 (19%), Positives = 413/1112 (37%), Gaps = 94/1112 (8%)
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
T + K + + +K S S + +S S+ ++R S T + + +
Sbjct: 287 TPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARK 346
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ---LQ 838
+ +++ L EK++ E+L AE L + + + K+ S +Q + L R
Sbjct: 347 ISGTT-ALQEALKEKQQHIEQLLAERDLERAE---VAKATSHVGEIEQELALARDGHDQH 402
Query: 839 VIEQEASVLRAKTQSLEADNEK------LQTENKKLQLLKNAKSLRSDKALDLNTKK--T 890
V+E EA + + +T AD EK L+ E +K++ L+ S DL K +
Sbjct: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQIS 462
Query: 891 TQLEN-ELKEALAKIKELE--MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
EN + K A+IKELE ++ + K++K R E T+ T + KS+
Sbjct: 463 EDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSR---IMELEKDL 519
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC-EIGEMYVV 1006
+ L+S K + ++ + L KL++ + E + E +
Sbjct: 520 ALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 579
Query: 1007 MKNAGLSGKEM--TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ + TA KL KE + ++SKL E N++N IA K +KLE
Sbjct: 580 REETHQKEIKALYTATEKLSKENESLKSKL-----EHANKEN--SDVIALWK---SKLE- 628
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXX 1124
A+ +A+E + S T T E + QI K+ D ++ D
Sbjct: 629 --TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD--SE 684
Query: 1125 XXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXC 1184
+ +N ++ ++KL K ++ D
Sbjct: 685 RAAHAKEMEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV 742
Query: 1185 KRIE--KQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTES 1242
K +E + + +V + ++ + R+ S E SE +L+ + E
Sbjct: 743 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 802
Query: 1243 KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
+ LE E K +K +S+ + +++ + L++ L + + K T E+
Sbjct: 803 QIKHLEIE----KNAESSKASSITRELQGRELKLTNLQENLSEVSQVK---ETLEKELQI 855
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
++ Q + KL + E + + ++ +L+ +LA +E
Sbjct: 856 LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 915
Query: 1363 XXXXXXXSSYWENKAKEL---DTDLQSERKKL-DRMRIAHDKDVKNKDAELATLKGKLKI 1418
EN E+ D S+ K+ D +R+ ++DV+ +L
Sbjct: 916 EEQLIKAKEKLENDIAEIMKMSGDNPSQLTKMNDELRLK-ERDVEELQLKLTKANENASF 974
Query: 1419 L-----------EQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE 1467
L EQ+ AK+ E K+E E + LE + + +EL +YE
Sbjct: 975 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS 1034
Query: 1468 EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
E TK + + Q LL + +L A E L ++L E EK + +
Sbjct: 1035 E---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL--EELRKQAEKAKAAQTAE 1089
Query: 1528 SLQERLCGGGWEVERARLNARL-DQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXD 1586
+ + E+ A L D ++ + N+ + E++ +
Sbjct: 1090 DAMQIM--EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1147
Query: 1587 YERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKS 1646
+++ + ++ Q E + AE ++ RDE+ S
Sbjct: 1148 NQKMEEFRKEIETLKQAAAQKSQQLSAL--QEENVKLAE----------ELGRSRDEVTS 1195
Query: 1647 LHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDE--EEYRNKVALL 1704
H ++ R +N Q+LE ++ IK+ D+ + SIS T E ++ L
Sbjct: 1196 -HQKLEEERSVLNN--QLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1252
Query: 1705 EQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
+V L E ++ L S + T L S+K E+++ ++ +L E +R LSS
Sbjct: 1253 RNEVTVLRGENASAKSLHSVVQT-LESDKVKLELKVKNLELQLK--ENKRQLSSSSGNTD 1309
Query: 1765 GLATRMELAWHKERDEQQRLLQETSTLARDLR 1796
A E A + D ++ + +DL+
Sbjct: 1310 TQADEDERAQESQIDFLNSVIVDLQRKNQDLK 1341
Score = 68.1 bits (159), Expect = 3e-10
Identities = 182/982 (18%), Positives = 381/982 (38%), Gaps = 96/982 (9%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
+K++ T E L+++++H+ Q + E + E R T + ++ +L A ++
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLE---RAEVAKATSHVGEIEQELALARDGHDQ 401
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSFKLKKTE 442
+ E E +LR + + AD E L +LE+ + L F++++
Sbjct: 402 HVLELEAKMDQLRTMV------------EAADREKVELLNQLEEEKRKVEDLQFRVEEES 449
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRE---NRIKELEQEVARSTEVALRLQRELAEA 499
LEQ+ +I P+ Q + RIKELEQ + A +LQREL +
Sbjct: 450 ITKGDLEQKS--------QISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDT 501
Query: 500 NSKFTGSNPSLMKVPQPETVKVSR-SSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLR 557
+M++ + ++V + L R PA + D+ SL +E + L+E+L
Sbjct: 502 RVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDV-DMSLSLLQEISSLQEKL- 559
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E T Q + + + +I T T + + S K +
Sbjct: 560 ---EVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN 616
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
S +++ K+ ET +I +H A K + E+ + ++ T+
Sbjct: 617 SDVIALWKSKLET---------AIASHQQAMEELKVSFSKGLGTET--AEFAELKTQIEK 665
Query: 678 RKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQ--- 733
+L L + ++ + EA A++ +++ E +R K+++ E
Sbjct: 666 MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 725
Query: 734 -DKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
+ E +++E K+ + A N + + +++L K+L ++D +RK
Sbjct: 726 VEMEDTLNKLQEAEIKVKELEVLQAKCNEQT-KVIDNFTSQLKATEEKLL--DLDALRKA 782
Query: 793 LIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
E + + ++L +L A+K+ K L ++ ++S ++ R+LQ E + + L+ +
Sbjct: 783 SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSI--TRELQGRELKLTNLQ---E 837
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSDKALDL--NTKKTTQLENELKEALAKI-KELEM 909
+L ++ +T K+LQ+LK + S++A+ + + ++T ++ +E + +LE
Sbjct: 838 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 897
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
+ ++ ++ + +F E ++E +K+K+ + L + D+
Sbjct: 898 L-RENLADMEAKFREKDEREEQLIKAKE----KLENDIAEIMKMSGDNPSQLTKMNDEL- 951
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
R+ ++ + +LQLK + + + + A K E+E E
Sbjct: 952 -----RLKERDVE---ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE 1003
Query: 1030 IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE-GDKDVFANKYKALENENSNLSNQCK 1088
+ KLS + + N+ Q A+ + ++ + +++ N K L + L K
Sbjct: 1004 LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL----K 1059
Query: 1089 TLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN 1148
EE ++ +L + A + QT
Sbjct: 1060 GAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL 1119
Query: 1149 YTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXX 1208
++D K LK V +++ + K++ T K
Sbjct: 1120 QNELDTLKENNLKNV----EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL 1175
Query: 1209 XXQAVVLANTHRRLSIELTSEKDELQARFI---------KTESKFITLEAEMRDLKADYE 1259
+ V LA R E+TS + + R + K ESKFI + + KA +
Sbjct: 1176 QEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI---KDADEEKASLQ 1232
Query: 1260 NKITSLESTIAAKDVHIKQLED 1281
I+ + + KD +++L +
Sbjct: 1233 KSISITSALLTEKDAELEKLRN 1254
Score = 57.2 bits (132), Expect = 6e-07
Identities = 112/602 (18%), Positives = 234/602 (38%), Gaps = 39/602 (6%)
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITS--LESTIAAKDV-HIKQLEDALRQTTN 1288
E +R+ + S L+ +++ + E + LE AK H+ ++E L
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA-LAR 396
Query: 1289 DKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE---AESSAAKLEMA 1343
D +D+ +E M ++R ++L K K+E + E S K ++
Sbjct: 397 DGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE 456
Query: 1344 QLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN-KAKELDTDLQSERKKL--DRMRIAH-D 1399
Q EN S +E KA +L +L+ R ++ RI +
Sbjct: 457 QKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELE 516
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRIT-ELKQEYEETVKKLEHSLALEKAEYEEL 1458
KD+ + E+A L+ +L E N AG ++ L QE +KLE + + E L
Sbjct: 517 KDLALRVQEVAELRRRL---ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSL 573
Query: 1459 TGKYELLEEEH-------VVTKARLTVEKEQAQGELLHVQKELSTALGEIKT-LQEKLGT 1510
+ EE H +L+ E E + +L H KE S + K+ L+ + +
Sbjct: 574 KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIAS 633
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD----QRERELRAANDRRDVL 1566
A K + + ++E+ RL+ + + Q +++ A +++
Sbjct: 634 HQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEME 693
Query: 1567 EHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE--KARKA 1624
++ K + +++ E +A+
Sbjct: 694 ALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCN 753
Query: 1625 EITDTKTRYEGQMNTMRD---ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKS 1681
E T + Q+ + +L +L S + E +Q LEAA+K + ++ +K+
Sbjct: 754 EQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI-EKN 812
Query: 1682 ARIHRNSISSTDEEEYRNKVALLEQ---QVACLEDELCESRLLASKLNTELVSEKSSAEV 1738
A + S + + + K+ L++ +V+ +++ L + + + E E S +
Sbjct: 813 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 872
Query: 1739 RLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+ E ++L++ EE+ +LSS ++ ME + ++ + +++L++ L D+ +
Sbjct: 873 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 932
Query: 1798 TL 1799
+
Sbjct: 933 IM 934
Score = 41.1 bits (92), Expect = 0.039
Identities = 105/615 (17%), Positives = 249/615 (40%), Gaps = 60/615 (9%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E+ + + +Q +E ++ + R++ S+ K + K R + E + + + L K
Sbjct: 754 EQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE--AAEKQIKHLEIEK 811
Query: 227 NSRNS--TNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQI-EGLKQEVDIL 283
N+ +S +++ ++G ++ ++ +++ E ++ V +
Sbjct: 812 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 871
Query: 284 RKRCERVEK--EKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKK 341
R E V K +K + ++++ + ++ + ++ +L E L ++
Sbjct: 872 RSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA 931
Query: 342 HLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXX 400
+ + + S+L + + R +E+L+ KL A L EDM +
Sbjct: 932 EIMKMSGDNPSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 991
Query: 401 XXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEH-EKKL 459
+ +++ + S L +++E + C+ L + ++ + +E ++ +K L
Sbjct: 992 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1051
Query: 460 LEIVGGPDGMQRENR--IKELEQ--------EVARSTEVALRLQRELA------------ 497
L+ G + EN ++ELE+ + A++ E A+++ ++
Sbjct: 1052 LDTEDKLKGAREENSGLLQELEELRKQAEKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1111
Query: 498 --EANSKFTGSNPSLMK--VPQPETVKVSRSSLT-RGGSQEDPAQLLRDL-----QDSLE 547
+ N+K +L + + E + S+ LT E+ + + L Q S +
Sbjct: 1112 TKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1171
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQ--VMTDNIVTCDIHESETVTNSIQNKMIH 605
A E ++ AEE + +V L+++ V+ + ++ ES+ + ++ + K
Sbjct: 1172 LSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK--- 1228
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
AS K S + L +K E + ++ L N +A +L +E D L
Sbjct: 1229 -ASL--QKSISITSALLTEKDAELEKLRNEVTVLRGEN-ASAKSLHSVVQTLESDKVKLE 1284
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
L++K + + + NK + +++ N + + DE + A+ + LN L+
Sbjct: 1285 LKVKNLELQLKE---------NKRQLSSSSGNTDTQADEDERAQESQIDFLN-SVIVDLQ 1334
Query: 726 RKVEELEQDKEALKK 740
RK ++L+ E + +
Sbjct: 1335 RKNQDLKMKVEMMSE 1349
>BC114213-1|AAI14214.1| 1392|Homo sapiens CAP-GLY domain containing
linker protein 1 protein.
Length = 1392
Score = 82.6 bits (195), Expect = 1e-14
Identities = 166/871 (19%), Positives = 355/871 (40%), Gaps = 80/871 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+K E L +E + L+ + E KE SD++ + ++TA + ++ E LK+
Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA-SHQQAMEELKVSFS 600
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
L + + K + + + + E+E Q +Q + A E L +LM
Sbjct: 601 -KGLGAETAEFAELKTQIEKMRLDYQHEIE-----NLQNQQNSERAAHAKEMEALRAKLM 654
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
++ + L + +D + D + L +E E +K VL K + +
Sbjct: 655 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIKVKELEVLQAKCNEQTKVI 713
Query: 446 DQLEQEKAEHEKKLLEIVG-GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
D + E+KLL++ + ++ +K+L Q++ + + L+ E +SK +
Sbjct: 714 DNFTSQPKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 773
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD-LREQLRNAEEET 563
S+ + Q +K++ QE+ ++ + ++++LE+E L+E+ A EE
Sbjct: 774 ----SITRELQGRELKLT-------NLQENLSE-VSQVKETLEKELQILKEKFAEASEEA 821
Query: 564 ANCKQVNPPTF--LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
+ ++ T L ++ N+++ D+ + ++ K +EK +
Sbjct: 822 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF---------REKDEREEQ 872
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
I + ++ +S N + E D E L L+L K A
Sbjct: 873 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL--- 929
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
+ SIE E+ EA + +E+E L RK+ +LE+ E Q
Sbjct: 930 ------QKSIEDMTVKAEQSQQEA--------AKKHEEEKKELERKLSDLEKKMETSHNQ 975
Query: 742 VKELTS---KISSVTKTSAGS-NTTARRSLTTNSNKL--AEERVKVLEDEIDEVRKKLIE 795
+EL + + +S TKT +++L +KL A E L E++E+RK+ +
Sbjct: 976 CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ-AD 1034
Query: 796 KERDCERLHAELSLAQKKPKTLIKS-RSLDASDQQNVDLKRQLQVIEQ----EASVLRAK 850
K + + + + ++ K ++ SL+ + Q N L+ +L +++ L
Sbjct: 1035 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1094
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
+ L +N+K++ K+++ LK A + +S + L ++ +L EL + ++ + +
Sbjct: 1095 KELLTVENQKMEEFRKEIETLKQAAAQKSQQ-LSALQEENVKLAEELGRSRDEVTSHQKL 1153
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
++E+S + E K+E+ +K A L+ L+++
Sbjct: 1154 -EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNE--- 1209
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEI 1030
+ + + L +V+ LE + ++ + +KN L KE K +L
Sbjct: 1210 -----VTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKE--NKRQLSSSSGNT 1262
Query: 1031 RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTL 1090
++ +++ ++ + L + I L+ N L+ ++ + AL +L+N
Sbjct: 1263 DTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE--AALNGNGDDLNNYD--- 1317
Query: 1091 TEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
+++ + + + +L D+ + L T DC
Sbjct: 1318 SDDQEKQSKKKPRLFCDICDCFDLHDT-EDC 1347
Score = 68.9 bits (161), Expect = 2e-10
Identities = 171/836 (20%), Positives = 327/836 (39%), Gaps = 83/836 (9%)
Query: 312 TTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIE-- 368
TT + + QQ + +L + R E T + EIE EL R + ++E
Sbjct: 350 TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAK 409
Query: 369 --QLRAKLLAAETLCEELMDENEDMKKELRDL---XXXXXXMQDNFREDQADEYS---SL 420
QLR + AA+ EL+++ E+ K+++ DL + + E S L
Sbjct: 410 MDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMEL 469
Query: 421 RRELEQTIKNCRVLSFKLKKTERKAD-----QLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
++L ++ L +L+ + D L QE + ++K LE+ QRE I
Sbjct: 470 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEK-LEVT--RTDHQRE--I 524
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP 535
L++ E + + L A K + N SL K K + + S+ +
Sbjct: 525 TSLKEHFGAREETHQKEIKALYTATEKLSKENESL-KSKLEHANKENSDVIALWKSKLET 583
Query: 536 AQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETV 595
A + Q E + + L E A K LD Q +N+ + SE
Sbjct: 584 A-IASHQQAMEELKVSFSKGLGAETAEFAELKTQIEKMRLDYQHEIENLQ--NQQNSERA 640
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
++ + + + A KEK +S K + H + N + ++
Sbjct: 641 AHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL-VEMEDTLNKLQEAEIKVKEL 699
Query: 656 RVEE---DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE-KETDEADPAEMK 711
V + + ++ ++ KA KL K S E ++ + ++ EA ++K
Sbjct: 700 EVLQAKCNEQTKVIDNFTSQPKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIK 759
Query: 712 -LLLELNEQ--EATVLRRKVE--------------ELEQDKEALKKQVKELTSKISSVTK 754
L +E N + +A+ + R+++ E+ Q KE L+K+++ L K + ++
Sbjct: 760 HLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE 819
Query: 755 TSAGSNTTARRSLTTNSNKL--AEERVKVLEDEIDEVRKKLIEKE---RDCERLHAELSL 809
+ + +RS+ NKL EE+ +L +++++R+ L + E R+ + +L
Sbjct: 820 EA----VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK 875
Query: 810 AQKKPKTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
A++K + I + D Q + +L++ E++ L+ K L NE K
Sbjct: 876 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK---LTKANENASFLQKS 932
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
++ + +A + ++ +LE +L + K++ CQ+ K+ + +E
Sbjct: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 992
Query: 928 KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL 987
K + L++ Q L+ L+ A K+
Sbjct: 993 KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA---------------- 1036
Query: 988 QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKT--KLEKEIDEIRSKLSKNDSEFTNEK 1045
+ + ED +I E K L+ E T +T KL+ E+D ++ KN E K
Sbjct: 1037 KAAQTAED-AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSK 1095
Query: 1046 NRLQTEIAKLKDVNAKLEGDKDVFANK---YKALENENSNLSNQCKTLTEEMKNRE 1098
L E K+++ ++E K A K AL+ EN L+ + +E+ + +
Sbjct: 1096 ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ 1151
Score = 62.1 bits (144), Expect = 2e-08
Identities = 175/901 (19%), Positives = 349/901 (38%), Gaps = 64/901 (7%)
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL 714
+R+ E + L L+++++A R +L PA + + + + E ++++
Sbjct: 464 SRIMELEKDLALRVQEVAELRR--RLESNKPAGDVDMSLSLLQEISSLQE----KLEVTR 517
Query: 715 ELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
+++E T L+ E +E +K++K L + ++K + + + NS+ +
Sbjct: 518 TDHQREITSLK---EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVI 574
Query: 775 AEERVKVLEDEIDEVRKKLIE-KERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDL 833
A + K LE I ++ + E K + L AE + + KT I+ LD Q ++
Sbjct: 575 ALWKSK-LETAIASHQQAMEELKVSFSKGLGAETAEFAEL-KTQIEKMRLDY--QHEIE- 629
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL 893
LQ Q+ S A + +EA KL K+ + A + DKA D + +
Sbjct: 630 --NLQ--NQQNSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 685
Query: 894 ENELKEALAKIKELEMICQDEKSEKKV--RFTEATKKETDTLKSKQXXXXXXXXXXXXXX 951
N+L+EA K+KELE++ + KV FT K + L
Sbjct: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQPKATEEKLLDLDALRKASSEGKSEMK 745
Query: 952 XXXXXXQATLKSLKD-DAQKSFKPRIPKKPTDLTTKLQ-----LKKMVEDLECEIGEMYV 1005
+A K +K + +K+ + K + +T +LQ L + E+L E+ ++
Sbjct: 746 KLRQQLEAAEKQIKHLEIEKNAE---SSKASSITRELQGRELKLTNLQENLS-EVSQVKE 801
Query: 1006 VMKNAGLSGKEMTAK-----TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
++ KE A+ +++ + E +KL + + +F N L +++ KL++ A
Sbjct: 802 TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF----NMLSSDLEKLRENLA 857
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD--LKNATSLQTTM 1118
+E + + L L N + + + +Q+ K++ + LK + +
Sbjct: 858 DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917
Query: 1119 SDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXX 1178
Q + K +++K +L +++ D KK+
Sbjct: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977
Query: 1179 XXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFI 1238
+R + T+ + + + A R + L E +EL+ +
Sbjct: 978 ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA---REENSGLLQELEELRKQAD 1034
Query: 1239 KTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK-QLE-DALRQTTNDKYDEATS 1296
K ++ T E M+ ++ + K +L S K + K Q E D L++ +E
Sbjct: 1035 KAKAA-QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1093
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK-LENX 1355
E++ + + E+ K + + SA + E +L +L + +
Sbjct: 1094 SKELLTVE------NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1147
Query: 1356 XXXXXXXXXXXXXXSSYWENKAKE--LDTDLQSERKKLDRMRIAHDKDVKNKDAELATLK 1413
+ E K +E D E+ L + + KDAEL L+
Sbjct: 1148 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1207
Query: 1414 GKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEE-HVVT 1472
++ +L + A AK + + Q E KLE L ++ E + K +L + T
Sbjct: 1208 NEVTVL-RGENASAKSLHSVVQTLESDKVKLE--LKVKNLELQLKENKRQLSSSSGNTDT 1264
Query: 1473 KARLTVEKEQAQGELLH-VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQE 1531
+A +++Q + L+ V +L ++K E + AA N ++ N + QE
Sbjct: 1265 QADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM--SEAALNGNGDDLNNYDSDDQE 1322
Query: 1532 R 1532
+
Sbjct: 1323 K 1323
Score = 59.3 bits (137), Expect = 1e-07
Identities = 151/799 (18%), Positives = 290/799 (36%), Gaps = 70/799 (8%)
Query: 1018 TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
TA KL KE + ++SKL E N++N IA K +KLE A+ +A+E
Sbjct: 547 TATEKLSKENESLKSKL-----EHANKEN--SDVIALWK---SKLE---TAIASHQQAME 593
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ S T E + QI K+ D ++ ++ +
Sbjct: 594 ELKVSFSKGLGAETAEFAELKTQIEKMRLDYQH--EIENLQNQQNSERAAHAKEMEALRA 651
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE--KQLSTRK 1195
+ +N ++ ++KL K ++ D K +E + +
Sbjct: 652 KLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQ 709
Query: 1196 DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLK 1255
+V + ++ + R+ S E SE +L+ + E + LE E K
Sbjct: 710 TKVIDNFTSQPKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE----K 765
Query: 1256 ADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXX 1315
+K +S+ + +++ + L++ L + + K T E+ ++
Sbjct: 766 NAESSKASSITRELQGRELKLTNLQENLSEVSQVK---ETLEKELQILKEKFAEASEEAV 822
Query: 1316 XXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
Q + KL + E + + ++ +L+ +LA +E EN
Sbjct: 823 SVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN 882
Query: 1376 KAKEL---DTDLQSERKKL-DRMRIAHDKDVKNKDAELATLKGKLKIL-----------E 1420
E+ D S+ K+ D +R+ ++DV+ +L L E
Sbjct: 883 DIAEIMKMSGDNSSQLTKMNDELRLK-ERDVEELQLKLTKANENASFLQKSIEDMTVKAE 941
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEK 1480
Q+ AK+ E K+E E + LE + + +EL +YE E TK +
Sbjct: 942 QSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSE---TKTKHEEIL 998
Query: 1481 EQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWE 1539
+ Q LL + +L A E LQE A + + + E++ +
Sbjct: 999 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMT----K 1054
Query: 1540 VERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXX 1599
+ L + D ++ + N+ + E++ + +++ + ++
Sbjct: 1055 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIET 1114
Query: 1600 XXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERD 1659
Q E + AE ++ RDE+ S H ++ R +
Sbjct: 1115 LKQAAAQKSQQLSAL--QEENVKLAE----------ELGRSRDEVTS-HQKLEEERSVLN 1161
Query: 1660 NYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDE--EEYRNKVALLEQQVACLEDELCE 1717
N Q+LE ++ IK+ D+ + SIS T E ++ L +V L E
Sbjct: 1162 N--QLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS 1219
Query: 1718 SRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKE 1777
++ L S + T L S+K E+++ ++ +L E +R LSS A E A +
Sbjct: 1220 AKSLHSVVQT-LESDKVKLELKVKNLELQLK--ENKRQLSSSSGNTDTQADEDERAQESQ 1276
Query: 1778 RDEQQRLLQETSTLARDLR 1796
D ++ + +DL+
Sbjct: 1277 IDFLNSVIVDLQRKNQDLK 1295
Score = 48.0 bits (109), Expect = 3e-04
Identities = 100/572 (17%), Positives = 218/572 (38%), Gaps = 42/572 (7%)
Query: 1251 MRDLKADYENKI---TSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXX 1307
+ + + Y KI T+L+ + K HI+QL A R + +ATS V +E
Sbjct: 336 LTETSSRYARKISGTTALQEALKEKQQHIEQLL-AERDLERAEVAKATSHVGEIEQELAL 394
Query: 1308 XXXXXXXXXXQDE--LNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXX 1365
+ E ++ + +E + E ++ + K + L+
Sbjct: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
Query: 1366 XXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGA 1425
+ +++ EL+ DL +++ +R + + D +++ L +L++ S
Sbjct: 455 LEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMS-----LSLLQEISSL 509
Query: 1426 GAK-RITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ 1484
K +T + E T K EH A E+ +E+ Y E +L+ E E +
Sbjct: 510 QEKLEVTRTDHQREITSLK-EHFGAREETHQKEIKALYTATE--------KLSKENESLK 560
Query: 1485 GELLHVQKELSTALGEIKT-LQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA 1543
+L H KE S + K+ L+ + + A K + + ++E+
Sbjct: 561 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGAETAEFAELKTQIEKM 620
Query: 1544 RLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXX 1603
RL+ Q E E + H + + I+
Sbjct: 621 RLDY---QHEIENLQNQQNSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ 677
Query: 1604 XXXXXXXXXXXIEQSE-KARKAEITDTKTR--------YEGQMNTMRD---ELKSLHNQV 1651
++++E K ++ E+ K + Q + +L +L
Sbjct: 678 HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQPKATEEKLLDLDALRKAS 737
Query: 1652 SRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQ---QV 1708
S + E +Q LEAA+K + ++ +K+A + S + + + K+ L++ +V
Sbjct: 738 SEGKSEMKKLRQQLEAAEKQIKHLEI-EKNAESSKASSITRELQGRELKLTNLQENLSEV 796
Query: 1709 ACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGLA 1767
+ +++ L + + + E E S + + E ++L++ EE+ +LSS ++
Sbjct: 797 SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 856
Query: 1768 TRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
ME + ++ + +++L++ L D+ + +
Sbjct: 857 ADMEAKFREKDEREEQLIKAKEKLENDIAEIM 888
Score = 44.0 bits (99), Expect = 0.006
Identities = 87/379 (22%), Positives = 159/379 (41%), Gaps = 37/379 (9%)
Query: 134 KRRLTGPLPDLDTGQTTNGSQTQLAITK-NDSLAERVRKMQ--LLKTQNSFEKEPSIEKE 190
K +L + ++ N SQ +TK ND L + R ++ LK + E ++K
Sbjct: 877 KEKLENDIAEIMKMSGDNSSQ----LTKMNDELRLKERDVEELQLKLTKANENASFLQKS 932
Query: 191 RERRSLSKSKEDEKTAR-YKDERSSTKDDVNFL-MQVKNSRNSTN-LKPPVRGGPXXXXX 247
E ++ + ++ A+ +++E+ + ++ L +++ S N LK
Sbjct: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 992
Query: 248 XXXXXXXXXXXXXL-VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANID 306
L + +K +++ GL QE++ LRK+ ++ + ++ ++
Sbjct: 993 KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQM 1052
Query: 307 TANKYTTGRSSE-----VLKLQQKVNELTTHN----EDLRDEKKHLT---QKIREIESEL 354
T K T S E KLQ +++ L +N E+L K+ LT QK+ E E+
Sbjct: 1053 TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI 1112
Query: 355 ETRPSTEAQTRQIEQLRAKLLAAETLCEEL---MDE---NEDMKKELRDLXXXXXXM--- 405
ET AQ Q QL A L EEL DE ++ +++E L M
Sbjct: 1113 ETLKQAAAQKSQ--QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1170
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG- 464
+ F +D +E +SL++ + T +L+K + L E A K L +V
Sbjct: 1171 ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS-AKSLHSVVQT 1229
Query: 465 -GPDGMQRENRIKELEQEV 482
D ++ E ++K LE ++
Sbjct: 1230 LESDKVKLELKVKNLELQL 1248
Score = 41.9 bits (94), Expect = 0.022
Identities = 105/615 (17%), Positives = 249/615 (40%), Gaps = 60/615 (9%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E+ + + +Q +E ++ + R++ S+ K + K R + E + + + L K
Sbjct: 708 EQTKVIDNFTSQPKATEEKLLDLDALRKASSEGKSEMKKLRQQLE--AAEKQIKHLEIEK 765
Query: 227 NSRNS--TNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQI-EGLKQEVDIL 283
N+ +S +++ ++G ++ ++ +++ E ++ V +
Sbjct: 766 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 825
Query: 284 RKRCERVEK--EKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKK 341
R E V K +K + ++++ + ++ + ++ +L E L ++
Sbjct: 826 RSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA 885
Query: 342 HLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXX 400
+ + + S+L + + R +E+L+ KL A L EDM +
Sbjct: 886 EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 945
Query: 401 XXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEH-EKKL 459
+ +++ + S L +++E + C+ L + ++ + +E ++ +K L
Sbjct: 946 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005
Query: 460 LEIVGGPDGMQRENR--IKELEQ--------EVARSTEVALRLQRELA------------ 497
L+ G + EN ++ELE+ + A++ E A+++ ++
Sbjct: 1006 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1065
Query: 498 --EANSKFTGSNPSLMK--VPQPETVKVSRSSLT-RGGSQEDPAQLLRDL-----QDSLE 547
+ N+K +L + + E + S+ LT E+ + + L Q S +
Sbjct: 1066 TKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1125
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQ--VMTDNIVTCDIHESETVTNSIQNKMIH 605
A E ++ AEE + +V L+++ V+ + ++ ES+ + ++ + K
Sbjct: 1126 LSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK--- 1182
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
AS K S + L +K E + ++ L N +A +L +E D L
Sbjct: 1183 -ASL--QKSISITSALLTEKDAELEKLRNEVTVLRGEN-ASAKSLHSVVQTLESDKVKLE 1238
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
L++K + + + NK + +++ N + + DE + A+ + LN L+
Sbjct: 1239 LKVKNLELQLKE---------NKRQLSSSSGNTDTQADEDERAQESQIDFLN-SVIVDLQ 1288
Query: 726 RKVEELEQDKEALKK 740
RK ++L+ E + +
Sbjct: 1289 RKNQDLKMKVEMMSE 1303
>AF001691-1|AAC17738.1| 1756|Homo sapiens 195 kDa cornified envelope
precursor protein.
Length = 1756
Score = 82.6 bits (195), Expect = 1e-14
Identities = 158/702 (22%), Positives = 297/702 (42%), Gaps = 72/702 (10%)
Query: 261 LVDSNVKEYQDQIEGLKQEV-----DILRKRCERVEKEKS--DILLRRLANIDTANKYTT 313
L+ ++ Q Q+ L+QE + + K R+E +++ D +L+ ++ +
Sbjct: 966 LLQEELEALQLQLRALEQETRDGGQEYVFKEVLRIEPDRAQADEVLQLREELEALRRQKG 1025
Query: 314 GRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIE-SELETRPSTEAQTRQIEQLRA 372
R +EVL LQQ+V L +EK +K+ E E +L+ P EA+ +Q+++
Sbjct: 1026 AREAEVLLLQQRVAALA-------EEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQ 1078
Query: 373 KLLAAETLCEE----LMDENEDMKKELRDLXXXXXXMQD--NFREDQAD--EYSSLRREL 424
+ EE L D+ + ++KE R + +++ +D A E S L R+
Sbjct: 1079 RQDQLREKQEEELSFLQDKLKRLEKE-RAMAEGKITVKEVLKVEKDAATEREVSDLTRQY 1137
Query: 425 EQTIKNCRVLSFKLKKTERKADQLEQEKAE--HEKKLLEIVGGPDGMQRENRIKELEQEV 482
E R + + RK LE+E A+ ++K+ EIV PD + E EV
Sbjct: 1138 EDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIV-RPD--------PKAESEV 1188
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
A LRL EL E K+ G+ L + + +L R G Q + ++ +++
Sbjct: 1189 AN-----LRL--ELVEQERKYRGAEEQL------RSYQSELEALRRRGPQVEVKEVTKEV 1235
Query: 543 QDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNK 602
+ + ++ ++L+ EE + ++ L+ + I + + T + +
Sbjct: 1236 -IKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQE 1294
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED-- 660
++ P +KE+ S K +EE + DL + +RV+E
Sbjct: 1295 ILQFQEDPQTKEEVASLRA---KLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVV 1351
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQ 719
+ ++ ++ +A + + + I+ + E +L LE Q
Sbjct: 1352 QQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQ 1411
Query: 720 EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-- 777
R+V+ L+Q AL+++ E K++ K + R +L EE
Sbjct: 1412 ARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQH 1471
Query: 778 RVKVLEDEIDEVRKKL--IEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
R ++LE E++ +R+KL +EK E++ S+ +K T + + L +S ++ KR
Sbjct: 1472 RRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKR 1531
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK--NAKSLRSDKALDLNTKKTTQL 893
+L V E S L A+ LE N K +K+L L+ N K + L L T++ L
Sbjct: 1532 ELDV---EVSRLEARLSELEFHNSK---SSKELDFLREENHKLQLERQNLQLETRR---L 1582
Query: 894 ENELKEALAKIKEL-EMICQDEKSEKKVRFTEATKKETDTLK 934
++E+ A + ++L M D + R + ++E D LK
Sbjct: 1583 QSEINMAATETRDLRNMTVADSGTNHDSRLW-SLERELDDLK 1623
Score = 59.7 bits (138), Expect = 1e-07
Identities = 176/878 (20%), Positives = 336/878 (38%), Gaps = 75/878 (8%)
Query: 278 QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLR 337
QE D L + +++ +K+ LL +A+ + + S + QQ V + E LR
Sbjct: 755 QETDSLSQMETKLKNQKN--LLDEIASREQEVQKICANSQQY---QQAVKDYELEAEKLR 809
Query: 338 DEKKHLTQKIREIESELETR-PSTEAQTRQIEQLRAKLLAAETLCEELMDENE---DMKK 393
+ + + P+T+ + + L AK + + + E ++ +
Sbjct: 810 SLLDLENGRSSHVSKRARLQSPATKVKEEEAA-LAAKFTEVYAINRQRLQNLEFALNLLR 868
Query: 394 ELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKA 453
+ ++ +Q N + +E +R+EL++ + R L ++K T+ + L +
Sbjct: 869 QQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGP 928
Query: 454 EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKV 513
+ E++ E ++L++ +A LQ EL +
Sbjct: 929 QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
Query: 514 PQPETVK-VSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
Q K V R R +Q D LR+ ++L R+ + A E Q
Sbjct: 989 GQEYVFKEVLRIEPDR--AQADEVLQLREELEALRRQ-------KGAREAEVLLLQQRVA 1039
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+++ VT E E V +QN A +E +K EE F
Sbjct: 1040 ALAEEKSRAQEKVT----EKEVV--KLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSF 1093
Query: 633 HFD-LPYLSIFNHMAANNLR-KTAARVEEDNES------LLLQLKKMATKARSRKLSPTP 684
D L L MA + K +VE+D + L Q + A KAR+ + T
Sbjct: 1094 LQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTE 1153
Query: 685 PANKL-SIETANDN---DEK--ETDEADP-AEMK---LLLELNEQEATV--LRRKVEELE 732
K+ ++E N EK E DP AE + L LEL EQE ++ +
Sbjct: 1154 LLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQ 1213
Query: 733 QDKEALKK-----QVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEE---RVKVLE 783
+ EAL++ +VKE+T ++ T R + +L E + L+
Sbjct: 1214 SELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLK 1273
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA--SDQQNVDLKRQLQVIE 841
EI ++ + + + + E+ Q+ P+T + SL A S++Q + + +
Sbjct: 1274 KEIQALKDT--KPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERAS 1331
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD--KALDLNTKKTTQLENELKE 899
QE + R + + +Q E + + ++ S +++D+ ++ +L EL+
Sbjct: 1332 QEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRR 1391
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+ ELE ++ + E++ R + E + + +Q +
Sbjct: 1392 LQRRRTELERQLEELERERQAR----REAEREVQRLQQRLAALEQEEAEAREKVTHTQKV 1447
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG--EMYVVMKNAGLSGKEM 1017
L+ A++ R+ + +L L+ +E L ++ E V + LS
Sbjct: 1448 VLQQDPQQAREHALLRLQLEEEQHRRQL-LEGELETLRRKLAALEKAEVKEKVVLSESVQ 1506
Query: 1018 TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
K E+EI ++S L E + K L E+++L+ ++LE + + L
Sbjct: 1507 VEKGDTEQEIQRLKSSLE----EESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLR 1562
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSA---DLKNAT 1112
EN L + + L E + +++IN + DL+N T
Sbjct: 1563 EENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMT 1600
Score = 41.1 bits (92), Expect = 0.039
Identities = 70/334 (20%), Positives = 131/334 (39%), Gaps = 26/334 (7%)
Query: 168 RVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKN 227
+V ++ K ++ +P +EKE +R + R E K ++ L K+
Sbjct: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQAL---KD 1281
Query: 228 SRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRC 287
++ K V+ L + K+ + E QE I RK
Sbjct: 1282 TKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKE- 1340
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKI 347
E + + K ++ + + + G +E + ++ + LR E + L ++
Sbjct: 1341 EELSRVKERVVQQEVVRYEEE----PGLRAEASAFAESIDVELRQIDKLRAELRRLQRRR 1396
Query: 348 REIESELE----TRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXX 403
E+E +LE R + R++++L+ +L A E +E E +K
Sbjct: 1397 TELERQLEELERERQARREAEREVQRLQQRLAALE------QEEAEAREKVTH--TQKVV 1448
Query: 404 XMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
QD QA E++ LR +LE+ ++L +L+ RK LE+ + + + L E V
Sbjct: 1449 LQQD---PQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESV 1505
Query: 464 GGPDG--MQRENRIK-ELEQEVARSTEVALRLQR 494
G Q R+K LE+E E+ + + R
Sbjct: 1506 QVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSR 1539
Score = 38.3 bits (85), Expect = 0.28
Identities = 88/438 (20%), Positives = 178/438 (40%), Gaps = 46/438 (10%)
Query: 1384 LQSERKKLDRMRIAHDKDV---KNKDAELATLKGKL--KILEQNSGAGAKRITELKQEYE 1438
L+ E + L R + A + +V + + A LA K + K+ E+ + +L+ EY+
Sbjct: 1013 LREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEV-VKLQNDPQLEAEYQ 1071
Query: 1439 ETVKKLEHSLALEKAEYEELT---GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELS 1495
+ + + L + + EEL+ K + LE+E + + ++TV+ E+L V+K+ +
Sbjct: 1072 QLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVK------EVLKVEKDAA 1125
Query: 1496 T--ALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRE 1553
T + ++ E ++ A EKTE+ I +L+E + E+ R R D +
Sbjct: 1126 TEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQ-EKVREIVRPDPK- 1183
Query: 1554 RELRAANDRRDVLEHHHD--------XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
E AN R +++E V ++ +
Sbjct: 1184 AESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE 1243
Query: 1606 XXXXXXXXXIEQSEKARKAEITDTKT-RYEGQMNTMRD-----ELKSLHNQVSRFRRERD 1659
E +K R E D + + + ++ ++D + K + ++ +F+ +
Sbjct: 1244 MEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQ 1303
Query: 1660 NYKQMLEAAQKSMAEIKNG---DKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE-- 1714
+++ K E K ++ I+ +EE R K +++Q+V E+E
Sbjct: 1304 TKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPG 1363
Query: 1715 -LCESRLLASKLNTELVS-EKSSAEV-----RLAEMQSRLNEYEEERLLSSGRAR-VAGL 1766
E+ A ++ EL +K AE+ R E++ +L E E ER R V L
Sbjct: 1364 LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRL 1423
Query: 1767 ATRMELAWHKERDEQQRL 1784
R+ +E + ++++
Sbjct: 1424 QQRLAALEQEEAEAREKV 1441
Score = 35.9 bits (79), Expect = 1.5
Identities = 38/199 (19%), Positives = 87/199 (43%), Gaps = 5/199 (2%)
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL 1433
+++ + L+ +L++ R+KL + A K+ + KG + Q + + +
Sbjct: 1470 QHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRS 1529
Query: 1434 KQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKE 1493
K+E + V +LE L+ + + + + + L EE+ +L +E++ Q E +Q E
Sbjct: 1530 KRELDVEVSRLEARLSELEFHNSKSSKELDFLREEN----HKLQLERQNLQLETRRLQSE 1585
Query: 1494 LSTALGEIKTLQEKLGTESAAWNTEKT-EMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
++ A E + L+ +S + + ++ + L+ E++ +
Sbjct: 1586 INMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAV 1645
Query: 1553 ERELRAANDRRDVLEHHHD 1571
+RE R + RR ++ H D
Sbjct: 1646 KREQRENHLRRSIVVIHLD 1664
>Z54367-1|CAA91196.1| 4684|Homo sapiens plectin protein.
Length = 4684
Score = 82.2 bits (194), Expect = 2e-14
Identities = 301/1601 (18%), Positives = 621/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 1102 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1160
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1161 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1220
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1221 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1276
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R ++ R Q LA+ + +
Sbjct: 1277 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1336
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1337 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1395
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1396 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1448
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE E L + ++ + R ++
Sbjct: 1449 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEE--EERLAEQQRAEERERLAEVEA 1504
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
+ E + EA + ++ E+ +E + + +Q K ++++++
Sbjct: 1505 ALEKQRQLAEAHAQAKAQAEREAKELQQRIQEEVVRREEAAV-----DAQQQKRSIQEEL 1559
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1560 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1615
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ EA R K ++L+A
Sbjct: 1616 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1675 LEELRLQAEEAERWLCQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1733
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E +++ + + K
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERQLERWQLKANEALRLRLQAEEVLQQ 1791
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1904
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K KA E E+ + S + K E R ++ + +A L+ +
Sbjct: 1905 LASKAKA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1961
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1962 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 2018
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 2019 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 2078
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 2136
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ ++ A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARSLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2194
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LDR+R + + + AE A + ++ +
Sbjct: 2195 V----------QQKEQELQQTLQQEQSVLDRLR--GEAEAARRAAEEAE---EARVQAER 2239
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A ++R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2359
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2471
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2527
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2628
Score = 63.7 bits (148), Expect = 6e-09
Identities = 136/703 (19%), Positives = 294/703 (41%), Gaps = 63/703 (8%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 2107
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+AK+ A +L E
Sbjct: 2108 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARSLRERA 2165
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFR-EDQADEYSSLRRE--LEQTIKNCRVLSFKLK-- 439
E+ R L Q + E++A ++ ++E L+QT++ + + +L+
Sbjct: 2166 EQESA------RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDRLRGE 2219
Query: 440 --KTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQREL 496
R A++ E+ + + E++ + + +R + +E Q A++ A +L++E
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2279
Query: 497 AEANSKFTGSNPSLMKVPQPETV------KVSRSSLTRGGSQEDPAQLLR-DLQDSLERE 549
+ ++ + + ++ Q K + +L + E LR L+++ ++
Sbjct: 2280 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2339
Query: 550 ADLREQLRNAEEETANC----KQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNK--- 602
L E+L+ + E QV F + M + E+E +++K
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2399
Query: 603 --MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED 660
+ + + ++ LS+ L+ +A L++ V+E
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459
Query: 661 N----ESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKLLL 714
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 715 ELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL------- 2571
Query: 775 AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLK 834
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+ L
Sbjct: 2572 -EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--QLL 2622
Query: 835 RQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q+E
Sbjct: 2623 QETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2680 QERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2720
Score = 62.9 bits (146), Expect = 1e-08
Identities = 246/1392 (17%), Positives = 530/1392 (38%), Gaps = 141/1392 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEK-SDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
+K+Y+ Q+ K +++ + ++ + + S+ +++ ++ T T +S+ +K
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1475
Query: 325 KVNELTTHNEDLRDEKK-HLTQKIREIESELE-----------TRPSTEAQTRQIEQ-LR 371
+ E L ++++ +++ E+E+ LE + E + ++++Q ++
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRIQ 1535
Query: 372 AKLLAAETLCEELMDENEDMKKELRDLXXXXXX-MQDNFREDQADEYSSLRRE------- 423
+++ E + + +++EL+ L +Q R+ +A E S LR E
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 424 --LEQTIKNCRVLSFKLKKTERKADQLEQEKA---EHEKKLLEIVGGPDGMQRENRIK-- 476
LE T + +L+ +A++ E +K E ++L V +R+ ++
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655
Query: 477 ---ELEQEVARSTEVAL------RLQRELAE---ANSKFTGSNPSLMKVPQPETVKVSRS 524
+ E E AR + AL RLQ E AE ++ + + + + +
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERWLCQAEVERARQVQVALETAQRSAEAEL 1715
Query: 525 SLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPT--FLDK-QVMT 581
R E AQL R LQ+ A LRE+ ++ A ++ L++ Q+
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERQLERWQLKA 1775
Query: 582 DNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDL--PYL 639
+ + + E +Q K + A KE+++ K E+ +L L
Sbjct: 1776 NEALRLRLQAEEV----LQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1831
Query: 640 SIFNHMAANNLRKTAA--------RVE-EDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+A ++ A R E E E L++ + + + T +L
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891
Query: 691 IETANDNDEKETDEADPA----EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELT 746
E A E E A A E + E ++Q + EL ++ L+ +E
Sbjct: 1892 AELAKVRAEMEVLLASKAKAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 747 SKISSVTKTSAGSNTTARRSLTT------NSNKL-AEERVKVLEDEIDEVRKKLIEKERD 799
+ + +A A R L + +L E + + E E + R + + ++
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 800 CERLHAELSLAQKK---PKTLIKSRSLDASDQQN-----VDLKRQLQVIEQEASVLRAKT 851
+R E AQ K + L + R S+ + D RQ + +E+E L+A
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071
Query: 852 QSLEADNEKLQTENKKLQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELE 908
+ A +L+ E +++ NA+ +LRS + +L + QL E E + A+ + +
Sbjct: 2072 EKAAAGKAELELELGRIR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2129
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
+ +E++ R +A +E + LK+K + +A K L+
Sbjct: 2130 SLAAEEEA---ARQRKAALEEVERLKAKVEEARSLRERAEQESARQLQLAQEAAQKRLQA 2186
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSG 1014
+ +K+ + +K +L LQ ++ V D E E + A S
Sbjct: 2187 E-EKAHAFAVQQKEQELQQTLQQEQSVLDRLRGEAEAARRAAEEAEEARVQAEREAAQSR 2245
Query: 1015 KEMTAKTKLEKEIDE---IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFAN 1071
+++ +L++ +E R++ + E + A+ + + + D
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305
Query: 1072 KYKALE----NENSNLSNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXX 1125
K+K + + + + TL +++ + Q N L +L+ A + +
Sbjct: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2365
Query: 1126 XXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXX 1182
+ +N I +DK+ + L+E +K K++ +
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2425
Query: 1183 XCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIK 1239
R+ + + QAV A T + EL ++ EL QAR ++
Sbjct: 2426 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQ 2484
Query: 1240 TESKFITLE-AE-----MRDLKADYENKI------TSLESTIAAKD-VHIKQLEDALR-Q 1285
+ + + + AE R L+A+ + ++ L+ +A + EDA R +
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2544
Query: 1286 TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQL 1345
++ E E+ Q + + +++ E E KL Q
Sbjct: 2545 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQ 2601
Query: 1346 KSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNK 1405
++ L +L++ + ++ E D+ LQ ER +++ + ++ +++
Sbjct: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDE 2660
Query: 1406 DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGK 1461
A+ L+ + + +Q +R+ +E + E + ++ E ++L +
Sbjct: 2661 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2720
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
ELL EE+ + +L + +EQ + L H ++ ++ + KTL G ++ + E
Sbjct: 2721 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAE 2778
Query: 1522 MQNSIASLQERL 1533
++S L+ ++
Sbjct: 2779 PEHSFDGLRRKV 2790
Score = 48.4 bits (110), Expect = 3e-04
Identities = 117/587 (19%), Positives = 216/587 (36%), Gaps = 44/587 (7%)
Query: 1211 QAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA 1270
Q + A RL E +E+ QA + + LE R +A+ ++K S A
Sbjct: 1669 QRALQALEELRLQAE-EAERWLCQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1727
Query: 1271 AKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEK 1330
+ +++ A+ Q + A E R +E +++ E+
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERQLERWQLKANEALRLRLQAEE 1787
Query: 1331 TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
+ S A+ E + K + + + K ++L +R
Sbjct: 1788 VLQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1847
Query: 1391 LDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLAL 1450
++ I + + + + L+ +L L++ + A T+ +QE LE LA
Sbjct: 1848 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA----TQKRQE-------LEAELAK 1896
Query: 1451 EKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELS--TALGEIKTLQEKL 1508
+AE E L EEE T + E G + +E + AL E Q +L
Sbjct: 1897 VRAEMEVLLASKAKAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1956
Query: 1509 GTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEH 1568
E AA ++ E + +A E+L G E R + A + +E+E RR +
Sbjct: 1957 AEEDAA--RQRAEAERVLA---EKLAAIG-EATRLKTEAEIALKEKEAENERLRRLAEDE 2010
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITD 1628
ER++++++ Q E+ A
Sbjct: 2011 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 2070
Query: 1629 TKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSM--AEIKNGDKSARIHR 1686
+ G+ + EL + + R ++ + LEAA++ AE + + A
Sbjct: 2071 FEKAAAGKAE-LELELGRIRSNAEDTLRSKEQAE--LEAARQRQLAAEEERRRREAEERV 2127
Query: 1687 NSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
+ +EE R + A LE +V L+ ++ E+R L E ++S+ +++LA+
Sbjct: 2128 QKSLAAEEEAARQRKAALE-EVERLKAKVEEARSL-----RERAEQESARQLQLAQ---- 2177
Query: 1747 LNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
E ++RL + +A + KE++ QQ L QE S L R
Sbjct: 2178 --EAAQKRLQAEEKAHAFAVQ-------QKEQELQQTLQQEQSVLDR 2215
Score = 33.9 bits (74), Expect = 6.0
Identities = 36/159 (22%), Positives = 68/159 (42%), Gaps = 7/159 (4%)
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL-TGKYELLE 1466
E TL L+I Q S A+R+ E E E +KL+ L + + EE+ T + E L
Sbjct: 2563 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2622
Query: 1467 EEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSI 1526
+E + EK+ LL ++ + +++ L + ++ E+ Q +
Sbjct: 2623 QETQALQQSFLSEKD----SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678
Query: 1527 ASLQERLCGGGWEVERARLNAR--LDQRERELRAANDRR 1563
++RL E R + A + +++ EL+ +R
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2717
>U63610-1|AAB05428.1| 4574|Homo sapiens plectin protein.
Length = 4574
Score = 82.2 bits (194), Expect = 2e-14
Identities = 302/1601 (18%), Positives = 622/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 992 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1050
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1051 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1110
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1111 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1166
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R +V R Q LA+ + +
Sbjct: 1167 EAQQPTFDALRDELRGAQEVGERLQQRHGERDLEVERWRERVAQVLERWQAVLAQTDLRQ 1226
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1227 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1285
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1286 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1338
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1339 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1391
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1392 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1449
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1450 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ E R K ++L+A
Sbjct: 1506 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAETEAAREKQRALQA 1564
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1623
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1794
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1795 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1851
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 1908
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 1909 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1968
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 2026
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ + A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 2027 AARQRKAALEEVERLKANVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2084
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2085 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2129
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A A+R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2130 EAAQARRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2361
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2417
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2518
Score = 72.1 bits (169), Expect = 2e-11
Identities = 241/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1400 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1518 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAETEAAREKQRALQALEEL--RLQAEE 1574
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1575 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1755 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1802
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 1920
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 1921 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 1978 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 2032
Query: 925 ATKKETDTLKS--KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+ ++ +A K L+ + +K+ + +K +
Sbjct: 2033 AALEEVERLKANVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2091
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A + +++ +L++ +E
Sbjct: 2092 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQARRQVEEAERLKQSAEEQ 2151
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2152 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2211
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2212 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2271
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2332 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2449
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2450 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2506
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2565
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2566 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2626 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2680
Score = 67.7 bits (158), Expect = 4e-10
Identities = 239/1367 (17%), Positives = 526/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1427
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1547
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1548 VKAETEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1602
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1783 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2021
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A + + + A
Sbjct: 2022 AAEEEAARQRKAALEEVERLKANVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2081
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQARR 2136
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2194
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2195 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2252
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2433 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2488
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2539
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2540 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2593
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2594 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2651
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2652 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2696
Score = 64.9 bits (151), Expect = 3e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1368 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K T+ E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1543 ELASRVKAETEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1600
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1658
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1659 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1778
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1779 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1832
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 1891
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 1892 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 1949
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 1950 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2004
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + ++ R ++ + +L
Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKANVEEARRLRERAEQESARQLQ 2064
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2125 VQAEREAAQARRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2183
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2303
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2364 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2413
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2414 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Score = 61.3 bits (142), Expect = 3e-08
Identities = 146/705 (20%), Positives = 287/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 1997
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+A + A L E
Sbjct: 1998 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKANVEEARRLRERA 2055
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2114
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2115 RAAEEAEEARVQAEREAAQARRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2175 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2347
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2461
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2462 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2510
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2511 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2567
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2568 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2610
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2159 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2270
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2387
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2448 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2504
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2505 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2564 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2622
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2623 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
>U53204-1|AAB05427.1| 4574|Homo sapiens plectin protein.
Length = 4574
Score = 82.2 bits (194), Expect = 2e-14
Identities = 302/1601 (18%), Positives = 622/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 992 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1050
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1051 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1110
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1111 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1166
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R +V R Q LA+ + +
Sbjct: 1167 EAQQPTFDALRDELRGAQEVGERLQQRHGERDLEVERWRERVAQVLERWQAVLAQTDLRQ 1226
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1227 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1285
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1286 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1338
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1339 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1391
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1392 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1449
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1450 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ E R K ++L+A
Sbjct: 1506 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAETEAAREKQRALQA 1564
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1623
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1794
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1795 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1851
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 1908
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 1909 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1968
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 2026
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ + A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 2027 AARQRKAALEEVERLKANVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2084
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2085 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2129
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A A+R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2130 EAAQARRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2361
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2417
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2518
Score = 72.1 bits (169), Expect = 2e-11
Identities = 241/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1400 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1518 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAETEAAREKQRALQALEEL--RLQAEE 1574
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1575 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1755 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1802
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 1920
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 1921 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 1978 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 2032
Query: 925 ATKKETDTLKS--KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+ ++ +A K L+ + +K+ + +K +
Sbjct: 2033 AALEEVERLKANVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2091
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A + +++ +L++ +E
Sbjct: 2092 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQARRQVEEAERLKQSAEEQ 2151
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2152 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2211
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2212 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2271
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2332 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2449
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2450 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2506
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2565
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2566 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2626 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2680
Score = 67.7 bits (158), Expect = 4e-10
Identities = 239/1367 (17%), Positives = 526/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1427
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1547
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1548 VKAETEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1602
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1783 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2021
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A + + + A
Sbjct: 2022 AAEEEAARQRKAALEEVERLKANVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2081
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQARR 2136
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2194
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2195 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2252
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2433 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2488
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2539
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2540 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2593
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2594 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2651
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2652 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2696
Score = 64.9 bits (151), Expect = 3e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1368 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K T+ E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1543 ELASRVKAETEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1600
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1658
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1659 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1778
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1779 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1832
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 1891
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 1892 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 1949
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 1950 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2004
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + ++ R ++ + +L
Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKANVEEARRLRERAEQESARQLQ 2064
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2125 VQAEREAAQARRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2183
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2303
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2364 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2413
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2414 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Score = 61.3 bits (142), Expect = 3e-08
Identities = 146/705 (20%), Positives = 287/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 1997
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+A + A L E
Sbjct: 1998 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKANVEEARRLRERA 2055
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2114
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2115 RAAEEAEEARVQAEREAAQARRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2175 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2347
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2461
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2462 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2510
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2511 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2567
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2568 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2610
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2159 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2270
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2387
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2448 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2504
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2505 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2564 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2622
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2623 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
>D25542-1|BAA05025.1| 3225|Homo sapiens golgi antigen gcp372 protein.
Length = 3225
Score = 82.2 bits (194), Expect = 2e-14
Identities = 266/1485 (17%), Positives = 588/1485 (39%), Gaps = 121/1485 (8%)
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAAETLCEEL 384
V ++ +++ EK L K+ SEL + Q + QI + ++ + +T+ E
Sbjct: 1270 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1329
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
E ++++L ++ + RE Q + L++ + + ++ LS +L + E
Sbjct: 1330 EVHAESLQQKLESSQLQIAGLE-HLRELQP-KLDELQKLISKKEEDVSYLSGQLSEKEAA 1387
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
+++ E E E + + Q E + KE ++ + + +V L ++ E + +
Sbjct: 1388 LTKIQTEIIEQEDLIKAL-----HTQLEMQAKEHDERI-KQLQVELCEMKQKPEEIGEES 1441
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQL--RNAEE 561
+ + + Q + + +L S ++ L R + L + AD+ Q+ +N E+
Sbjct: 1442 RAKQQIQRKLQAALIS-RKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1500
Query: 562 ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK--SDSP 619
+T + DK ++T+ + + E++++++S ++ + KEK +
Sbjct: 1501 DTVLGRLALLQEERDK-LITE--MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIE 1557
Query: 620 PLSIDKTTEETQF---HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
L K E T++ H +L + N+ A R++ E++ + +++ K R
Sbjct: 1558 SLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR 1617
Query: 677 SRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE 736
S + ANK ET EK+ EA+ EM+ + E + A ++K+ ELE++ +
Sbjct: 1618 STE------ANKK--ET-----EKQLQEAEQ-EMEEMKEKMRKFAKSKQQKILELEEEND 1663
Query: 737 ALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEK 796
L+ +V +T SN + + L ERVK+ E + + KK
Sbjct: 1664 RLRAEVHPAGDTAKECMETLLSSNASMKEEL---------ERVKM---EYETLSKKFQSL 1711
Query: 797 ERDCERLHAEL-SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLE 855
+ + L E+ L + + K +L+A+++ + Q V E+ + +T+ E
Sbjct: 1712 MSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD----NQTNVTEEGTQSIPGETE--E 1765
Query: 856 ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEK 915
D+ + T + + +AKS ++ A+ + ++ N L++ + ++KE ++EK
Sbjct: 1766 QDSLSMSTRPTCSESVPSAKS--ANPAVSKDFSSHDEINNYLQQ-IDQLKERIAGLEEEK 1822
Query: 916 SEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
+ K F++ + E +TL S+ ++ K K
Sbjct: 1823 QKNK-EFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK-LKET 1880
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLS 1035
++ DL +L + +L IG + +A + + + ++ K + + S+L
Sbjct: 1881 AEEEKDDLEERLM--NQLAELNGSIGNYCQDVTDAQIKNELLESEM---KNLKKCVSELE 1935
Query: 1036 KNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+ + EK ++++EI K+ K++G + NK A E + L + + + + K
Sbjct: 1936 EEKQQLVKEKTKVESEIR--KEYLEKIQGAQKEPGNKSHAKELQEL-LKEKQQEVKQLQK 1992
Query: 1096 NREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQ 1154
+ K+SA + +L+ ++ ++ ++ +D
Sbjct: 1993 DCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD 2052
Query: 1155 DKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVV 1214
+++ + + D K + K+ ++ L R ++ + +
Sbjct: 2053 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL- 2111
Query: 1215 LANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAA 1271
+ RR + L E+Q K + + L+ + A + ++SL+
Sbjct: 2112 --DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDR 2169
Query: 1272 KDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT 1331
K+ E K +E + + + ++N ++++ +K
Sbjct: 2170 VIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV-LKDQLRQMSIHMEELKINISRLEHDKQ 2228
Query: 1332 EAESSA-AKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
ES A ++++ Q D + EN SS +N+ +L+++L+S + +
Sbjct: 2229 IWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS--QNELAKLESELKSLKDQ 2286
Query: 1391 LDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI-TELKQEYEETVKKLEHSLA 1449
L + + +K K + L + + + QNS +++ T+L+ E T + E
Sbjct: 2287 LTDLSNSLEK-CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2345
Query: 1450 LEKAEYEELTGKYEL-------LEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIK 1502
E+ L+GK E L ++H L Q + E + +++E A+ +
Sbjct: 2346 KEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN 2405
Query: 1503 TLQEKLGT---ESAAWNTEKTEMQNSIASLQ---ERLCGGGWEVERARLNARL--DQRER 1554
L E L T E+ + S++SLQ +R+ G ++E L+ L DQ +
Sbjct: 2406 QLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQ 2465
Query: 1555 ELRAANDR-----RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXX 1609
E A N++ R + H D E ++++
Sbjct: 2466 EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQL 2525
Query: 1610 XXXXXIEQSEKARKAEITDTKTRYEG---QMNTMRDELKSLHNQVSRFRRERDNYKQMLE 1666
+E + ++ +++ E N +++E + L ++ + + +
Sbjct: 2526 QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT 2585
Query: 1667 AAQK----SMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES-RLL 1721
A Q+ + + K +HR S + ++ ++A LE+++ C++ E + +
Sbjct: 2586 ALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK---RIAELEEELVCVQKEAAKKVGEI 2642
Query: 1722 ASKLNTELV----------SEKSSAEVRLAEMQSRLNEYEEERLL 1756
KL EL +E +AE R+AE+ L E E++ L+
Sbjct: 2643 EDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2687
Score = 76.6 bits (180), Expect = 9e-13
Identities = 291/1531 (19%), Positives = 613/1531 (40%), Gaps = 142/1531 (9%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAK---LLAAE 378
++QK +L +E L++E+K KI++++ L + + + IE+++A+ +L E
Sbjct: 29 IRQKDVQLQQKDEALQEERKAADNKIKKLK--LHAKAKLTSLNKYIEEMKAQGGTVLPTE 86
Query: 379 TLCEELMDEN-----------EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQT 427
EE + ++ E +K +L++ +Q + QA++ + E+E+
Sbjct: 87 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEF 146
Query: 428 IKNCRVLSFKLKKTERKADQLEQEKAEHEKKL---LEIVGGPDG-MQRENRIKELE-QEV 482
+ + L K + QL Q +AE +L ++V D + + R+ E E ++
Sbjct: 147 VMMKQQLQEKEEFISTLQAQLSQTQAEQAAQLSSMQQVVREKDARFETQVRLHEDELLQL 206
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
+V +Q++L K SL V + + V + + LT + E Q+L
Sbjct: 207 VTQADVETEMQQKLRVLQRKLEEHEESL--VGRAQVVDLLQQELT---AAEQRNQILSQQ 261
Query: 543 QDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH---ESETVTNS 598
+E E + LR + EE+ + ++++ N+ ++H E
Sbjct: 262 LQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQE-EMHHLLEQFEQAGQ 320
Query: 599 IQNKMIHAASTPSSKEKSD-----SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR-- 651
Q ++ S K K++ S LS+ KT +E Q D + N +
Sbjct: 321 AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 380
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSI-ETANDNDEKETDEADPAEM 710
++A +++ + L + K+++ L A++ S + N+ + T+E +
Sbjct: 381 QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ 440
Query: 711 KLLLEL-NEQEATVLRR-KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
K ++EL NE+ A +L ++EEL+ + E L Q+ L ++ +T + S+
Sbjct: 441 KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQ----NRTGEADREVSEISIV 496
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKK---PKTLIKSRSLDA 825
+NK + + +D ++ +K ++ L E+ AQ++ K ++ + +
Sbjct: 497 DIANKRSSSAEESGQDVLENT---FSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEE 553
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL 885
+D + +D K Q+ + + ++ K + + N++ L ++ ++A
Sbjct: 554 ADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSL----PAVEKEQASTE 609
Query: 886 NTKKTTQLENELKEALAKIKELEMICQDEKSEKKV-RFTEATKKETDTLKSKQXXXXXXX 944
+ +T++ E L +A ++K + +KS V + + E + LKS+
Sbjct: 610 HQSRTSE-EISLNDAGVELKSTKQ--DGDKSLSAVPDIGQCHQDELERLKSQILELELNF 666
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
+A S + + FK + T L + + L ++ E+
Sbjct: 667 HKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTA---LSEERDQLLSQVKELS 723
Query: 1005 VVMK-NAGLSGKEMT-AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
+V + A + EM A+ + ++ +D + +D+ T + + L E AK KDV K+
Sbjct: 724 MVTELRAQVKQLEMNLAEAERQRRLD--YESQTAHDNLLTEQIHSLSIE-AKSKDV--KI 778
Query: 1063 EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCM 1122
E V N+ ++ + S S ++L +++N+E+++ + + +++ +S +S +
Sbjct: 779 E----VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQAL 834
Query: 1123 XXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVG-DKTKKIGDXXXXXXXXX 1181
V+ + ++K++ + E+ T+K+
Sbjct: 835 ---SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLG 891
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARF--IK 1239
K +++QL+ + L + +S K+ELQ F +K
Sbjct: 892 VEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLK 951
Query: 1240 TESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPV 1298
E+ E R L+A N+ L+ + +LE+ L ++ K + S
Sbjct: 952 KEN-----EQRKRKLQAALINRKELLQ--------RVSRLEEELANLKDESKKEIPLSET 998
Query: 1299 EMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXX 1358
E E+ + +I L++T +E ++E+ ++ D LE
Sbjct: 999 ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEK---EVELQHIRKD---LEEKLAA 1052
Query: 1359 XXXXXXXXXXXSSYWENKAKELDTDLQ---SERKKLDRMRIAHDKDVKNKDAELATLKGK 1415
+ ++K ++D LQ SE + + + I + D + D+ +A +K
Sbjct: 1053 EEQFQALVKQMNQTLQDKTNQIDL-LQAEISENQAIIQKLITSNTDASDGDS-VALVKET 1110
Query: 1416 LKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKAR 1475
+ I +G+ K E EE + LALEK E E+L K L+E KA
Sbjct: 1111 VVISPPCTGSS----EHWKPELEEKI------LALEK-EKEQLQKK---LQEALTSRKAI 1156
Query: 1476 LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCG 1535
L ++AQ + H+++EL + LQE+ +S +++ ++E + G
Sbjct: 1157 L----KKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDG 1212
Query: 1536 GGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQ- 1594
++ + E L A E HH E S +Q
Sbjct: 1213 KLPSTDQQESCSSTPGLEEPLFKAT------EQHHTQPVLESNLCPDWPSHSEDASALQG 1266
Query: 1595 RXXXXXXXXXXXXXXXXXXXIEQSEKARKAEIT---DTKTRYEGQMNTMRDELKSLHNQV 1651
+E + +E+T + + + Q+N E++SL
Sbjct: 1267 GTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVS 1326
Query: 1652 SRFRRERDNYKQMLEAAQKSMAEIKN-GDKSARIH--RNSISSTDEEEYRNKVALLEQQV 1708
++ +Q LE++Q +A +++ + ++ + IS +E+ L E++
Sbjct: 1327 HEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEA 1386
Query: 1709 AC--LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEE--ERLLSSGRARVA 1764
A ++ E+ E L L+T+L + + R+ ++Q L E ++ E + RA+
Sbjct: 1387 ALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK-Q 1445
Query: 1765 GLATRMELAW--HKERDEQQRLLQETSTLAR 1793
+ +++ A KE ++ + LQE +LAR
Sbjct: 1446 QIQRKLQAALISRKEALKENKSLQEELSLAR 1476
Score = 72.1 bits (169), Expect = 2e-11
Identities = 268/1493 (17%), Positives = 591/1493 (39%), Gaps = 143/1493 (9%)
Query: 170 RKMQ-LLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNS 228
+K Q L+ ++S +E K + ++SK E T ++ ++ + T++ +
Sbjct: 1706 KKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEE 1765
Query: 229 RNSTNL--KPPVRGGPXXXXXXXXXXXXXXXXXXLVDS---NVKEYQDQIEGLKQEVDIL 283
++S ++ +P +++ + + +++I GL++E
Sbjct: 1766 QDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKN 1825
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNE----LTTHNEDLRDE 339
++ + +E EK + LL +++ D K +++ L Q++ E +T E +E
Sbjct: 1826 KEFSQTLENEK-NTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE 1884
Query: 340 KKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLX 399
K L +++ +EL Q Q++ +LL +E + L ++++E + L
Sbjct: 1885 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE--MKNLKKCVSELEEEKQQLV 1942
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKL 459
++ R++ ++ ++E + + L LK+ +++ QL+++ +++K+
Sbjct: 1943 KEKTKVESEIRKEYLEKIQGAQKE-PGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKI 2001
Query: 460 --LE-IVGGPDGMQRENRIKELE---QEVARSTEVALRLQRELAEANSKFTGSNPSLMKV 513
LE V + +Q E++ K+LE + +A++ E + Q ELA + +V
Sbjct: 2002 SALERTVKALEFVQTESQ-KDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2060
Query: 514 PQPETVKVSRSSLTRGGS-QEDPAQLLRDLQDSLER--EADLREQLRNAEE--ETANCKQ 568
+ +K+ + + S + Q DL+ LE+ E L+E+ +N +E + ++
Sbjct: 2061 -LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK-KNMQEKLDALRREK 2118
Query: 569 VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTE 628
V+ + + +T N ++ + + +S ++ AA T S D ID+ +
Sbjct: 2119 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL--AAFTKSMSSLQDDRDRVIDEAKK 2176
Query: 629 ETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL-QLKKMATKARSRKLSPTPPAN 687
+ D A ++ R++EDN S+L QL++M+ K++ + +
Sbjct: 2177 WERKFSD-----------AIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2225
Query: 688 KLSI-----ETANDNDEKETDEADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKK 740
I +T +K D +LL +L E + ++ +LE + ++LK
Sbjct: 2226 DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD 2285
Query: 741 QVKELTSKISSVTKTSAGSNTTAR-RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERD 799
Q+ +L++ + + R + ++K + E+ LE ++ R+
Sbjct: 2286 QLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ---LETDLQASREL------- 2335
Query: 800 CERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ--LQVIEQEASVLRAKTQSLEAD 857
RLH E+++ ++K +L+ + +A +L++Q ++ E E + + + +++ +
Sbjct: 2336 TSRLHEEINMKEQKIISLLSGKE-EAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLE 2394
Query: 858 NEKLQTENKKLQLLKNAKSLRSD----KA-LDLNTKKTTQLENELKEALAKIKELEMICQ 912
E + +K QL++ K+++ + KA LD K + L+N+ + ++LE
Sbjct: 2395 EENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHL 2454
Query: 913 DEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSF 972
EK EA E + LK + A L ++D +
Sbjct: 2455 SIILEKDQLIQEAA-AENNKLKEE---IRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2510
Query: 973 KPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE-----MTAKTKLEKEI 1027
+ ++ L +LQ K +E+ ++ E + A + K L KEI
Sbjct: 2511 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEI 2570
Query: 1028 DEIRSKLSKNDSEFT--NEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
+ ++ +S+ + T E+ L A+LK ++ +F++ K + + L
Sbjct: 2571 ESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI----AELEE 2626
Query: 1086 QCKTLTEEMKNREAQI-NKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
+ + +E + +I +KL +LK+ M +
Sbjct: 2627 ELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLL 2686
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
V TK ++ ++ G + + KR K ++ K+
Sbjct: 2687 MV---TKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKR--KYDASLKELAQLKEQG 2741
Query: 1205 XXXXXXQAVVLANTHRRLSIELTS--EKDELQARFIKTESKFITLEAEMRDLKADYENKI 1262
A++ S E S ++L + + + + + L +++ D ++
Sbjct: 2742 LLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFS 2801
Query: 1263 TSLESTIAAKDVHIKQLEDALRQTTNDKYDEA----TSPVEMVEMRXXXXXXXXXXXXXQ 1318
++ S +D H+ + R++ K A TSP E+ ++
Sbjct: 2802 KAMASLQNERD-HLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLL 2860
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
EL N L++ + + E+ LK+ L + ++ + W+++
Sbjct: 2861 KELKN----LQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELD 2916
Query: 1379 ELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQE-- 1436
+L + S RM+ + + +KD +L+ L+ ++ L +S + +++
Sbjct: 2917 QLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQAS 2976
Query: 1437 --------------YEETVKKLEHSLALEKAEYEEL------TGKYELLEEEHVVT---- 1472
YE + + + + +L++ +EL + +LLEE++ ++
Sbjct: 2977 PETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLC 3036
Query: 1473 -KARLTVEKEQAQGELLHVQKELSTALGEIK-----------TLQEKLGTESAAWNTEKT 1520
++ E +Q G+LL+ L + E++ QEK G + E
Sbjct: 3037 DTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELR 3096
Query: 1521 EMQNSIASLQERLCGGGWEVERAR--LNARLDQR---ERELRAANDRRDVLEH 1568
E Q S + Q++LC EV R L DQR E L A ++ LEH
Sbjct: 3097 EPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEH 3149
Score = 70.1 bits (164), Expect = 7e-11
Identities = 296/1539 (19%), Positives = 587/1539 (38%), Gaps = 158/1539 (10%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEV---- 319
S++ Q + L+ D L+ + ++ ++K++ ++ I +S E+
Sbjct: 345 SHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFL 404
Query: 320 --LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
L LQQ T D+ +E TQ + E E S + + ++E + LL +
Sbjct: 405 NRLPLQQHETASQTSFPDVYNEG---TQAVTE-----ENIASLQKRVVELENEKGALLLS 456
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
EEL ENE + ++ ++ R +AD S ++ I N R S +
Sbjct: 457 SIELEELKAENEKLSSQI-------TLLEAQNRTGEADREVSEISIVD--IANKRSSSAE 507
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL--QRE 495
E D LE ++ K+L ++ Q E +L+ + R+ E + Q+E
Sbjct: 508 ----ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKE 563
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
+ + + G P MKV +T + ++E + Q S E ++ E+
Sbjct: 564 MKQMEGE--GIAPIKMKVFLEDTGQ----DFPLMPNEESSLPAVEKEQASTEHQSRTSEE 617
Query: 556 --LRNAEEETANCKQVNPPTFLDKQVMT-DNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
L +A E + KQ DK + +I C E E + + I ++
Sbjct: 618 ISLNDAGVELKSTKQDG-----DKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 672
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
EK+ +D+ +E L + F A NN A + E+ + LL Q+K+++
Sbjct: 673 YEKN------LDEKAKEISNLNQL--IEEFKKNADNNSSAFTA-LSEERDQLLSQVKELS 723
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQ---EATVLRRKV 728
R +L + A ++ D E+ A LL E EA K+
Sbjct: 724 MVTELRA-----QVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKI 778
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE--ERVKVLEDEI 786
E L+ + + ++ Q E ++ I S+ + L +++ E ERV+ + ++
Sbjct: 779 EVLQNELDDVQLQFSEQSTLIRSL-----------QSQLQNKESEVLEGAERVRHISSKV 827
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+E+ + L +KE + ++ L ++ +TL QQ ++ K Q QV E S+
Sbjct: 828 EELSQALSQKELEITKMDQLLLEKKRDVETL----------QQTIEEKDQ-QVTEISFSM 876
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
Q L + L E K L+ N S R+++A ++ ++ + LK+ E
Sbjct: 877 TEKMVQ-LNEEKFSLGVEIKTLKEQLNLLS-RAEEAKKEQVEEDNEVSSGLKQ---NYDE 931
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
+ Q K E + F + KKE + K K + L +LKD
Sbjct: 932 MSPAGQISKEELQHEF-DLLKKENEQRKRK---LQAALINRKELLQRVSRLEEELANLKD 987
Query: 967 DAQKSFKPRIPKK---PTDLTTKLQLKKMVEDLECEIGEMYVVM----KNAGLSG--KEM 1017
+++K ++ D K +K V +C+ E+Y+ K L K++
Sbjct: 988 ESKKEIPLSETERGEVEEDKENKEYSEKCVTS-KCQEIEIYLKQTISEKEVELQHIRKDL 1046
Query: 1018 TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL-EGDKDVFANKYKAL 1076
K E++ + ++++ + TN+ + LQ EI++ + + KL + D AL
Sbjct: 1047 EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1106
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXX 1136
E +S C +E K + K+ A K LQ + + +
Sbjct: 1107 VKETVVISPPCTGSSEHWKPELEE--KILALEKEKEQLQKKLQEALTSRKAILKKAQEKE 1164
Query: 1137 XXXXXXXXQV-DNYTKIDQDKNKLLKE---VGDKTKKIGDXXXXXXXXXXXCKRIEKQLS 1192
Q D+Y ++ + ++ KE +GD+ +++ ++ S
Sbjct: 1165 RHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCS 1224
Query: 1193 TRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMR 1252
+ Q V+ +N L + S ++ A ++ + ++A+++
Sbjct: 1225 STPGLEEPLFKATEQHHTQPVLESN----LCPDWPSHSEDASA--LQGGTSVAQIKAQLK 1278
Query: 1253 DLKAD---YENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
+++A+ E K++S S + K + QL++ + + +E+ ++
Sbjct: 1279 EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK----------QGLEIESLKTVSHE 1328
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
Q +L ++++++ E + ++ +L+ ++K E
Sbjct: 1329 AEVHAESLQQKLESSQLQIAGLE-HLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAA 1387
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
+ + + E + +++ +L+ HD+ +K EL +K K + + + S A
Sbjct: 1388 LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA---- 1443
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLH 1489
KQ+ + +KL+ +L K +E E L T RLT + ++
Sbjct: 1444 ----KQQIQ---RKLQAALISRKEALKENKSLQEELSLARG-TIERLTKSLADVESQVSA 1495
Query: 1490 VQKELSTALGEIKTLQE---KLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER--AR 1544
KE T LG + LQE KL TE E + +S SL+ L G + E+
Sbjct: 1496 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1555
Query: 1545 LNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXX 1604
+ + + E ++ L+ ++ + V + R
Sbjct: 1556 IESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK 1615
Query: 1605 XXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRE----RDN 1660
E+ + + E+ + K + + + ++ L + R R E D
Sbjct: 1616 LRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDT 1675
Query: 1661 YKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRL 1720
K+ +E S A +K + ++ ++S + K +L E +V L+ ++ E
Sbjct: 1676 AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE-EVQDLKHQI-EGN- 1732
Query: 1721 LASKLNTELVSEKSSAEVRLAE--MQSRLNEYEEERLLS 1757
++ + N E +EK + + E QS E EE+ LS
Sbjct: 1733 VSKQANLE-ATEKHDNQTNVTEEGTQSIPGETEEQDSLS 1770
Score = 58.0 bits (134), Expect = 3e-07
Identities = 145/798 (18%), Positives = 314/798 (39%), Gaps = 63/798 (7%)
Query: 188 EKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXX 247
+KE + S+E+E+ ++E D N LM+ + N++ +
Sbjct: 2373 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ----LDSF 2428
Query: 248 XXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDT 307
+V + + + + ++ ++++ K K +I R +++D
Sbjct: 2429 VKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLR-SHMDD 2487
Query: 308 ANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETR-PSTEAQTRQ 366
N +E+++ ++ +N++ T + ++K L + + ELE + E + ++
Sbjct: 2488 LNSENAKLDAELIQYREDLNQVITIKD---SQQKQLLEVQLQQNKELENKYAKLEEKLKE 2544
Query: 367 IEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSL-RRELE 425
E+ L + L +E +D+ KE+ L + Q + L +L+
Sbjct: 2545 SEEANEDLRRS---FNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLK 2601
Query: 426 QTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGG-PDGMQRENRIKELEQEVAR 484
+ LS ++++ +LE+E +K+ + VG D +++E + + + R
Sbjct: 2602 VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR 2661
Query: 485 S-TEVA----LRLQRELAEANSKF---TGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA 536
+ TE A L R+L E K T N L Q +S +R + E+
Sbjct: 2662 NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELD 2721
Query: 537 QLLRDLQDSLEREADLREQ-LRNAE-----EETA---NCKQVNPPTFLDKQVMTDNIVTC 587
+L R SL+ A L+EQ L N E ETA N + N + L+K + +++
Sbjct: 2722 ELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEK--LNQQLLSK 2779
Query: 588 D---IHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNH 644
D +H S + +S + + S + + D ++K + + +
Sbjct: 2780 DEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSP 2839
Query: 645 MAANNLRKTAARVEEDNESLLLQLKKM---------------ATKARSRKLSPTPPANKL 689
+L+K + ++ D + LL +LK + KA+ ++ A ++
Sbjct: 2840 AEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQI 2899
Query: 690 SIETANDNDEKETDEADPAEM-KLLLELNEQE-ATVLRRKVEELEQDKEALKKQVKELTS 747
E + E D M K E++E+ + + +Q L+ ++EL S
Sbjct: 2900 MQEELRQENLSWQHELDQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRS 2959
Query: 748 KISSV--TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHA 805
S K + S + + ++ ++L ++++ K++ +KE ++L++
Sbjct: 2960 SSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNS 3019
Query: 806 ELSLAQKKPKTLI-----KSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK 860
S ++ TL S+SL + Q DL V+E++ L+A +++
Sbjct: 3020 NFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGA 3079
Query: 861 LQTEN---KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSE 917
Q +N +K + + +S T Q NEL++ L + ++ + ++ S
Sbjct: 3080 PQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSV 3139
Query: 918 KKVRFTEATKKETDTLKS 935
+ + E D+ ++
Sbjct: 3140 AEEQIRRLEHSEWDSSRT 3157
Score = 46.4 bits (105), Expect = 0.001
Identities = 78/416 (18%), Positives = 170/416 (40%), Gaps = 35/416 (8%)
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
N+ +++ E +L++EL + ++R+K +L+Q EAL+++ K +KI +
Sbjct: 4 NNTTQEDVQERLAYAEQLVVELKD----IIRQKDVQLQQKDEALQEERKAADNKIKKLKL 59
Query: 755 TSAGSNTT---------ARRSLTTNSNKLAEERVK-------VLEDEIDEVRKKLIEKER 798
+ T+ A+ + +EE++ E EI++++ KL EKE
Sbjct: 60 HAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEE 119
Query: 799 DCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADN 858
L A+L+ AQ + + ++ V +K+QLQ E+ S L+A+ +A+
Sbjct: 120 LISTLQAQLTQAQAE-----QPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQ 174
Query: 859 EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEK 918
+ +Q + K R + + L+ + QL + ++L ++ K E+
Sbjct: 175 ---AAQLSSMQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVL--QRKLEE 229
Query: 919 KVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPK 978
+ D L+ + TL++ + ++ K + K
Sbjct: 230 HEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEK 289
Query: 979 KPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKN 1037
++ + K +L+ E+ + + AG + E+ ++ + LE++ + + +
Sbjct: 290 MELEVAER---KLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 346
Query: 1038 DSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA-NKYKALENENSNLSNQCKTLTE 1092
LQ+ LKD N+KL DK+ A + ++ L + K +++
Sbjct: 347 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ 402
>BC126305-1|AAI26306.1| 1438|Homo sapiens CLIP1 protein protein.
Length = 1438
Score = 82.2 bits (194), Expect = 2e-14
Identities = 182/897 (20%), Positives = 365/897 (40%), Gaps = 72/897 (8%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D E +Q+E K++V+ L+ R E K D+ + + D N T + + +L
Sbjct: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQISEDPENTQTKLEHARIKEL 480
Query: 323 QQ-------KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLR--A 372
+Q K ++L ED R +I E+E +L R A+ R++E +
Sbjct: 481 EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAG 540
Query: 373 KLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNF---REDQADEYSSLRRELEQTIK 429
+ + +L +E+ E ++ D ++++F E E +L E+ K
Sbjct: 541 DVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK 600
Query: 430 NCRVLSFKLKKTERK--------ADQLEQEKAEHEKKLLEI-VGGPDGMQREN-RIKELE 479
L KL+ ++ +LE A H++ + E+ V G+ E EL+
Sbjct: 601 ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELK 660
Query: 480 QEVARSTEVALRLQRELAEANSKFTGSNPS------LMKVPQPETVKVSRSSLTRGGSQE 533
++ + + L Q E+ ++ + ++ + +K +SL S+
Sbjct: 661 TQIEK---MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 717
Query: 534 DPA--QLLRDLQDSLEREADLREQLRNAEEETANC-KQVNPPTFLDKQVMTDNIVTCDIH 590
D A Q L +++D+L + + +++ E A C +Q Q+ D+
Sbjct: 718 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD 777
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL 650
++ +++M + EK L I+K E ++ L + NL
Sbjct: 778 ALRKASSEGKSEMKKLRQQLEAAEK-QIKHLEIEKNAESSKASSITRELQ-GRELKLTNL 835
Query: 651 RKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
++ + V + E+L +L+ + K + ET N +KE E
Sbjct: 836 QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ-ETVNKLHQKE--EQFNMLS 892
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L +L E A + K E ++ +E L K ++L + I+ + K S G N++ LT
Sbjct: 893 SDLEKLRENLAD-MEAKFREKDEREEQLIKAKEKLENDIAEIMKMS-GDNSS---QLTKM 947
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
+++L R+K E +++E++ KL + + L + K + + + +++
Sbjct: 948 NDEL---RLK--ERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ-SQQEAAKKHEEEK 1001
Query: 831 VDLKRQLQVIEQEASVLRAKTQSLEADNEKL--QTENKKLQLLKNAKS--LRSDKALDLN 886
+L+R+L +E++ + Q L+A E+ +T+ K ++L+N + L ++ L
Sbjct: 1002 KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA 1061
Query: 887 TKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS----KQXXXXX 942
++ + L EL+E L K + Q + ++ + TK++T+TL S KQ
Sbjct: 1062 REENSGLLQELEE-LRKQADKAKAAQTAEDAMQI-MEQMTKEKTETLASLEDTKQTNAKL 1119
Query: 943 XXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGE 1002
+ KS + ++ K +K + T K + + L E
Sbjct: 1120 QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIE-TLKQAAAQKSQQLSALQEE 1178
Query: 1003 MYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKL---SKNDSEFTNEKNRLQTEIAKLKDVN 1059
+ + G S E+T+ KLE+E + ++L K +S+F + + + + K +
Sbjct: 1179 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISIT 1238
Query: 1060 AKLEGDKDV----FANKYKALENENS---NLSNQCKTLTEEMKNREAQINKLSADLK 1109
+ L +KD N+ L EN+ +L + +TL + E ++ L LK
Sbjct: 1239 SALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 1295
Score = 76.6 bits (180), Expect = 9e-13
Identities = 218/1112 (19%), Positives = 412/1112 (37%), Gaps = 94/1112 (8%)
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
T + K + + +K S S + +S S+ ++R S T + + +
Sbjct: 287 TPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARK 346
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ---LQ 838
+ +++ L EK++ E+L AE L + + + K+ S +Q + L R
Sbjct: 347 ISGTT-ALQEALKEKQQHIEQLLAERDLERAE---VAKATSHVGEIEQELALARDGHDQH 402
Query: 839 VIEQEASVLRAKTQSLEADNEK------LQTENKKLQLLKNAKSLRSDKALDLNTKK--T 890
V+E EA + + +T AD EK L+ E +K++ L+ S DL K +
Sbjct: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQIS 462
Query: 891 TQLEN-ELKEALAKIKELE--MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
EN + K A+IKELE ++ + K++K R E T+ T + KS+
Sbjct: 463 EDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSR---IMELEKDL 519
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC-EIGEMYVV 1006
+ L+S K + ++ + L KL++ + E + E +
Sbjct: 520 ALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 579
Query: 1007 MKNAGLSGKEM--TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ + TA KL KE + ++SKL E N++N IA K +KLE
Sbjct: 580 REETHQKEIKALYTATEKLSKENESLKSKL-----EHANKEN--SDVIALWK---SKLE- 628
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXX 1124
A+ +A+E + S T T E + QI K+ D ++ D
Sbjct: 629 --TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD--SE 684
Query: 1125 XXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXC 1184
+ +N ++ ++KL K ++ D
Sbjct: 685 RAAHAKEMEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV 742
Query: 1185 KRIE--KQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTES 1242
K +E + + +V + ++ + R+ S E SE +L+ + E
Sbjct: 743 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 802
Query: 1243 KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
+ LE E K +K +S+ + +++ + L++ L + + K T E+
Sbjct: 803 QIKHLEIE----KNAESSKASSITRELQGRELKLTNLQENLSEVSQVK---ETLEKELQI 855
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
++ Q + KL + E + + ++ +L+ +LA +E
Sbjct: 856 LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 915
Query: 1363 XXXXXXXSSYWENKAKEL---DTDLQSERKKL-DRMRIAHDKDVKNKDAELATLKGKLKI 1418
EN E+ D S+ K+ D +R+ ++DV+ +L
Sbjct: 916 EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK-ERDVEELQLKLTKANENASF 974
Query: 1419 L-----------EQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE 1467
L EQ+ AK+ E K+E E + LE + + +EL +YE
Sbjct: 975 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS 1034
Query: 1468 EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAWNTEKTEMQNSI 1526
E TK + + Q LL + +L A E LQE A + +
Sbjct: 1035 E---TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1091
Query: 1527 ASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXD 1586
+ E++ + + L + D ++ + N+ + E++ +
Sbjct: 1092 MQIMEQMT----KEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1147
Query: 1587 YERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKS 1646
+++ + ++ Q E + AE ++ RDE+ S
Sbjct: 1148 NQKMEEFRKEIETLKQAAAQKSQQLSAL--QEENVKLAE----------ELGRSRDEVTS 1195
Query: 1647 LHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDE--EEYRNKVALL 1704
H ++ R +N Q+LE ++ IK+ D+ + SIS T E ++ L
Sbjct: 1196 -HQKLEEERSVLNN--QLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1252
Query: 1705 EQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
+V L E ++ L S + T L S+K E+++ ++ +L E +R LSS
Sbjct: 1253 RNEVTVLRGENASAKSLHSVVQT-LESDKVKLELKVKNLELQLK--ENKRQLSSSSGNTD 1309
Query: 1765 GLATRMELAWHKERDEQQRLLQETSTLARDLR 1796
A E A + D ++ + +DL+
Sbjct: 1310 TQADEDERAQESQIDFLNSVIVDLQRKNQDLK 1341
Score = 67.7 bits (158), Expect = 4e-10
Identities = 182/982 (18%), Positives = 380/982 (38%), Gaps = 96/982 (9%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
+K++ T E L+++++H+ Q + E + E R T + ++ +L A ++
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLE---RAEVAKATSHVGEIEQELALARDGHDQ 401
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSFKLKKTE 442
+ E E +LR + + AD E L +LE+ + L F++++
Sbjct: 402 HVLELEAKMDQLRTMV------------EAADREKVELLNQLEEEKRKVEDLQFRVEEES 449
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRE---NRIKELEQEVARSTEVALRLQRELAEA 499
LEQ+ +I P+ Q + RIKELEQ + A +LQREL +
Sbjct: 450 ITKGDLEQKS--------QISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDT 501
Query: 500 NSKFTGSNPSLMKVPQPETVKVSR-SSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLR 557
+M++ + ++V + L R PA + D+ SL +E + L+E+L
Sbjct: 502 RVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDV-DMSLSLLQEISSLQEKL- 559
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E T Q + + + +I T T + + S K +
Sbjct: 560 ---EVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN 616
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
S +++ K+ ET +I +H A K + E+ + ++ T+
Sbjct: 617 SDVIALWKSKLET---------AIASHQQAMEELKVSFSKGLGTET--AEFAELKTQIEK 665
Query: 678 RKLSPTPPANKLSIETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQ--- 733
+L L + ++ + EA A++ +++ E +R K+++ E
Sbjct: 666 MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 725
Query: 734 -DKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
+ E +++E K+ + A N + + +++L K+L ++D +RK
Sbjct: 726 VEMEDTLNKLQEAEIKVKELEVLQAKCNEQT-KVIDNFTSQLKATEEKLL--DLDALRKA 782
Query: 793 LIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
E + + ++L +L A+K+ K L ++ ++S ++ R+LQ E + + L+ +
Sbjct: 783 SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSI--TRELQGRELKLTNLQ---E 837
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSDKALDL--NTKKTTQLENELKEALAKI-KELEM 909
+L ++ +T K+LQ+LK + S++A+ + + ++T ++ +E + +LE
Sbjct: 838 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 897
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
+ ++ ++ + +F E ++E +K+K+ + L + D+
Sbjct: 898 L-RENLADMEAKFREKDEREEQLIKAKE----KLENDIAEIMKMSGDNSSQLTKMNDEL- 951
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
R+ ++ + +LQLK + + + + A K E+E E
Sbjct: 952 -----RLKERDVE---ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE 1003
Query: 1030 IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE-GDKDVFANKYKALENENSNLSNQCK 1088
+ KLS + + N+ Q A+ + ++ + +++ N K L + L K
Sbjct: 1004 LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL----K 1059
Query: 1089 TLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN 1148
EE ++ +L A + QT
Sbjct: 1060 GAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL 1119
Query: 1149 YTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXX 1208
++D K LK V +++ + K++ T K
Sbjct: 1120 QNELDTLKENNLKNV----EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL 1175
Query: 1209 XXQAVVLANTHRRLSIELTSEKDELQARFI---------KTESKFITLEAEMRDLKADYE 1259
+ V LA R E+TS + + R + K ESKFI + + KA +
Sbjct: 1176 QEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI---KDADEEKASLQ 1232
Query: 1260 NKITSLESTIAAKDVHIKQLED 1281
I+ + + KD +++L +
Sbjct: 1233 KSISITSALLTEKDAELEKLRN 1254
Score = 57.2 bits (132), Expect = 6e-07
Identities = 112/602 (18%), Positives = 234/602 (38%), Gaps = 39/602 (6%)
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITS--LESTIAAKDV-HIKQLEDALRQTTN 1288
E +R+ + S L+ +++ + E + LE AK H+ ++E L
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA-LAR 396
Query: 1289 DKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE---AESSAAKLEMA 1343
D +D+ +E M ++R ++L K K+E + E S K ++
Sbjct: 397 DGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE 456
Query: 1344 QLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN-KAKELDTDLQSERKKL--DRMRIAH-D 1399
Q EN S +E KA +L +L+ R ++ RI +
Sbjct: 457 QKSQISEDPENTQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELE 516
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRIT-ELKQEYEETVKKLEHSLALEKAEYEEL 1458
KD+ + E+A L+ +L E N AG ++ L QE +KLE + + E L
Sbjct: 517 KDLALRVQEVAELRRRL---ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSL 573
Query: 1459 TGKYELLEEEH-------VVTKARLTVEKEQAQGELLHVQKELSTALGEIKT-LQEKLGT 1510
+ EE H +L+ E E + +L H KE S + K+ L+ + +
Sbjct: 574 KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIAS 633
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD----QRERELRAANDRRDVL 1566
A K + + ++E+ RL+ + + Q +++ A +++
Sbjct: 634 HQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEME 693
Query: 1567 EHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSE--KARKA 1624
++ K + +++ E +A+
Sbjct: 694 ALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCN 753
Query: 1625 EITDTKTRYEGQMNTMRD---ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKS 1681
E T + Q+ + +L +L S + E +Q LEAA+K + ++ +K+
Sbjct: 754 EQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI-EKN 812
Query: 1682 ARIHRNSISSTDEEEYRNKVALLEQ---QVACLEDELCESRLLASKLNTELVSEKSSAEV 1738
A + S + + + K+ L++ +V+ +++ L + + + E E S +
Sbjct: 813 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 872
Query: 1739 RLAEMQSRLNEYEEE-RLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+ E ++L++ EE+ +LSS ++ ME + ++ + +++L++ L D+ +
Sbjct: 873 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 932
Query: 1798 TL 1799
+
Sbjct: 933 IM 934
Score = 41.5 bits (93), Expect = 0.030
Identities = 105/615 (17%), Positives = 249/615 (40%), Gaps = 60/615 (9%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E+ + + +Q +E ++ + R++ S+ K + K R + E + + + L K
Sbjct: 754 EQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE--AAEKQIKHLEIEK 811
Query: 227 NSRNS--TNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQI-EGLKQEVDIL 283
N+ +S +++ ++G ++ ++ +++ E ++ V +
Sbjct: 812 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 871
Query: 284 RKRCERVEK--EKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKK 341
R E V K +K + ++++ + ++ + ++ +L E L ++
Sbjct: 872 RSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA 931
Query: 342 HLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXX 400
+ + + S+L + + R +E+L+ KL A L EDM +
Sbjct: 932 EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 991
Query: 401 XXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEH-EKKL 459
+ +++ + S L +++E + C+ L + ++ + +E ++ +K L
Sbjct: 992 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1051
Query: 460 LEIVGGPDGMQRENR--IKELEQ--------EVARSTEVALRLQRELA------------ 497
L+ G + EN ++ELE+ + A++ E A+++ ++
Sbjct: 1052 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1111
Query: 498 --EANSKFTGSNPSLMK--VPQPETVKVSRSSLT-RGGSQEDPAQLLRDL-----QDSLE 547
+ N+K +L + + E + S+ LT E+ + + L Q S +
Sbjct: 1112 TKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1171
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQ--VMTDNIVTCDIHESETVTNSIQNKMIH 605
A E ++ AEE + +V L+++ V+ + ++ ES+ + ++ + K
Sbjct: 1172 LSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK--- 1228
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
AS K S + L +K E + ++ L N +A +L +E D L
Sbjct: 1229 -ASL--QKSISITSALLTEKDAELEKLRNEVTVLRGEN-ASAKSLHSVVQTLESDKVKLE 1284
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
L++K + + + NK + +++ N + + DE + A+ + LN L+
Sbjct: 1285 LKVKNLELQLKE---------NKRQLSSSSGNTDTQADEDERAQESQIDFLN-SVIVDLQ 1334
Query: 726 RKVEELEQDKEALKK 740
RK ++L+ E + +
Sbjct: 1335 RKNQDLKMKVEMMSE 1349
>BC007808-1|AAH07808.1| 1006|Homo sapiens MYH7B protein protein.
Length = 1006
Score = 81.8 bits (193), Expect = 2e-14
Identities = 178/909 (19%), Positives = 365/909 (40%), Gaps = 67/909 (7%)
Query: 190 ERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKN----SRNSTNLKPPVRGGPXXX 245
E++ L S E EK R ER+ K + + + ++ +++ L+ ++
Sbjct: 100 EQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 159
Query: 246 XXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDIL--LRRLA 303
+ +KE Q + E L++E++ R RVEK++++ L L+
Sbjct: 160 SQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELS 219
Query: 304 -NIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEA 362
++ A + G+ K + ++ L E+ + +R + E
Sbjct: 220 ERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALR--RKQAEGAAELGE 277
Query: 363 QTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSL 420
Q ++++R KL E EL E +D+ + L + R EDQ E
Sbjct: 278 QVDSLQRVRQKL---EKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIK 334
Query: 421 RRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKEL 478
EL++ + + +L+ + +L +EK E + ++ G E ++L
Sbjct: 335 VEELQRQLADASTQRGRLQTESGELSRLLEEK---ECLISQLSRGKALAAQSLEELRRQL 391
Query: 479 EQEVARSTEVALRLQR------ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ 532
E+E + +A +Q L E + + + L ++ +V++ R +
Sbjct: 392 EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQ---WRSKYE 448
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
D Q +L+++ ++ A LR Q E AN K + L+K + + T ES
Sbjct: 449 ADAIQRTEELEEAKKKLA-LRLQEAEEGVEAANAK----CSSLEKAKL--RLQT----ES 497
Query: 593 ETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRK 652
E VT ++ + AA+ K++ L ++ +E + +L + L +
Sbjct: 498 EDVTLELE-RATSAAAALDKKQRHLERALE-ERRRQEEEMQRELEAAQRESRGLGTELFR 555
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE-KETDEADPAEMK 711
EE E+ L+ K K ++S LS ++ + ++ K+ E + +E++
Sbjct: 556 LRHGHEEALEA--LETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ 613
Query: 712 LLLE-----LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS 766
LE L +E LR ++ EL Q K + +++ E + +++ + + + + S
Sbjct: 614 AALEEAEGALELEETKTLRIQL-ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQAS 672
Query: 767 L--TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
L T + A K +E +++++ +L R A L Q + K + D
Sbjct: 673 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKE--EQAGRD 730
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA-----DNEKLQTENKKLQLLKNAKSLRS 879
+ +L Q Q +E+ AS+L A+ + L A + + E + L+ + L S
Sbjct: 731 EEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHS 790
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXX 939
LN KK +LE +L + +++E ++ + + K T+A + LK +Q
Sbjct: 791 QNTGLLNQKK--KLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMM-AEELKKEQDT 847
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPK---KPTDLTTKL--QLKKMVE 994
QA L+ + A + K ++ K K +L +L + KK E
Sbjct: 848 SAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 907
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
L+ V + A + ++ +++ +D+++SK+ +F + + T +AK
Sbjct: 908 ALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAK 967
Query: 1055 LKDVNAKLE 1063
+ +L+
Sbjct: 968 YRKAQHELD 976
Score = 71.3 bits (167), Expect = 3e-11
Identities = 170/899 (18%), Positives = 347/899 (38%), Gaps = 86/899 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKT-- 755
DE + D +++L L E+E KV+ L ++ AL + V LT + ++ +
Sbjct: 17 DECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 76
Query: 756 SAGSNTTA---RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQK 812
A + A R S T + E++V+ LE +++ +K ++ ER +L +L L Q+
Sbjct: 77 QALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 136
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
S+ + Q L+ +L+ + E S L + + + ++Q + K+LQ
Sbjct: 137 ---------SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ--- 184
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD- 931
A++ ++ L+ ++E + EA +++EL ++ + K+E +
Sbjct: 185 -ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAEL 243
Query: 932 -TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
L+ + A + D+ + + ++ K+ K +L+
Sbjct: 244 GRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKE------KSELR 297
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSK---LSKNDSEFTNEKNR 1047
V+DL + + +A E +T E ++ E + K L + ++ + ++ R
Sbjct: 298 MEVDDLAANVETLTRAKASA-----EKLCRT-YEDQLSEAKIKVEELQRQLADASTQRGR 351
Query: 1048 LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
LQTE +L + LE + + + + +L + L EE K + A + + A
Sbjct: 352 LQTESGELSRL---LEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA- 407
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKLLKEVGDK 1166
L++ L + +V + +K + D + +E+ +
Sbjct: 408 LRHDCDLLREQHE------EEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEA 461
Query: 1167 TKKIG----DXXXXXXXXXXXCKRIEK---QLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
KK+ + C +EK +L T + VT
Sbjct: 462 KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHL 521
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R E +++E+Q + + L E+ L+ +E + +LE+ +K+
Sbjct: 522 ERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALET--------LKRE 573
Query: 1280 EDALRQTTNDKYDEAT-SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAA 1338
L++ +D D+ + S + E+ Q L A+ LE E ++
Sbjct: 574 NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRI 633
Query: 1339 KLEMAQLKSDL-----------AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
+LE++Q+K+++ A L + N+A L ++ +
Sbjct: 634 QLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGD 693
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
L+ +++ H + +A+ AT + ++ E+ +G ++ L E E + LE
Sbjct: 694 LNDLE-LQLGH-ATRQATEAQAATRLMQAQLKEEQAGRDEEQ--RLAAELHEQAQALERR 749
Query: 1448 LALEKAEYEELTGKYE-------LLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE 1500
+L AE EEL E L E+E + RL + Q G LL+ +K+L L +
Sbjct: 750 ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG-LLNQKKKLEADLAQ 808
Query: 1501 IK-TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
+ ++E A K + ++ +E R+ L+Q REL+A
Sbjct: 809 LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQA 867
Score = 70.9 bits (166), Expect = 4e-11
Identities = 175/886 (19%), Positives = 355/886 (40%), Gaps = 110/886 (12%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTGRSSEVL 320
++ +D+ LK+++D L + EKEK L +A +D + T +
Sbjct: 13 RKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 72
Query: 321 KL-QQKVNELTTHNE---DLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIE-QLR 371
+ QQ + +L + L K L Q++ ++E LE R TE R++E L+
Sbjct: 73 EAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLK 132
Query: 372 AKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDN-----FREDQADEYSSLRRELEQ 426
+ ++ E +KK+ +L ++D + + E + ELE+
Sbjct: 133 LTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEE 192
Query: 427 TIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST 486
++ R +++K +A + +E +E LE GG QRE ++ E E+
Sbjct: 193 ELEAERAARARVEKQRAEAARELEELSER----LEEAGGASAGQREG-CRKREAELG--- 244
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL 546
RL+REL EA + + +L + ++ G Q D Q +R L
Sbjct: 245 ----RLRRELEEAALRHEATVAALRRKQAEGAAEL--------GEQVDSLQRVR---QKL 289
Query: 547 EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ----NK 602
E+E + +LR ++ A N T + + + C +E + I+ +
Sbjct: 290 EKE---KSELRMEVDDLA----ANVETLTRAKASAEKL--CRTYEDQLSEAKIKVEELQR 340
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ AST + +++S LS + EE + + LS +AA +L + ++EE+++
Sbjct: 341 QLADASTQRGRLQTESGELS--RLLEEKECL--ISQLSRGKALAAQSLEELRRQLEEESK 396
Query: 663 S----------------LLLQLKKMATKARS--RKLSPTPPANKLSIETANDNDE-KETD 703
+ LL + + +A++ ++L A + + D + T+
Sbjct: 397 AKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTE 456
Query: 704 EADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
E + A+ KL L L E E V K LE+ K L+ + +++T ++ T +A +
Sbjct: 457 ELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDK 516
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
R + + EER + + +E++++L +R+ L EL + + ++
Sbjct: 517 KQR-----HLERALEERRR----QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE-- 565
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
+L+ ++N +L+ ++ + + S+ Q LE + L+ E ++Q A ++
Sbjct: 566 ALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ----AALEEAEG 621
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
AL+L KT +++ EL + A++ + +EK + ++S Q
Sbjct: 622 ALELEETKTLRIQLELSQVKAEVDR-------KLAEKDEECANLRRNHQRAVESLQASLD 674
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ L L + Q R + T +Q + E +
Sbjct: 675 AETRARNEALRLKKKMEGDLNDL--ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE 732
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
+ + E A + L E++E+R+ L + + + L +L ++++
Sbjct: 733 QRLAAELHEQAQALERRA-SLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 791
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
G N+ K LE + + LS + + +E + E + K D
Sbjct: 792 NTG----LLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITD 833
Score = 54.4 bits (125), Expect = 4e-06
Identities = 175/937 (18%), Positives = 346/937 (36%), Gaps = 81/937 (8%)
Query: 650 LRKTAARVE---EDNESLLLQLKK--MATKARSRKLSPTPPANKLSIETANDNDEKETDE 704
L K R+E ED E L Q KK M T+ RKL KL+ E+ D +
Sbjct: 92 LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL---KLTQESVADAAQ----- 143
Query: 705 ADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
D +++ L+ + E + L +VE+ + ++K++KEL ++ + + A
Sbjct: 144 -DKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAER--AA 200
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
R+ A ++ L + ++E + C + AEL +++ +
Sbjct: 201 RARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEAT 260
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
+ + + ++ EQ S+ R + Q LE + +L+ E L N ++L KA
Sbjct: 261 VAALRRKQAEGAAELGEQVDSLQRVR-QKLEKEKSELRMEVD--DLAANVETLTRAKASA 317
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK-----KETDTLKSKQXX 939
+T E++L EA K++EL+ D +++ TE+ + +E + L S+
Sbjct: 318 EKLCRT--YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 375
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIP----KKPTDLTTKLQLKKMVED 995
++ KS A ++ + + + + +L++++
Sbjct: 376 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 435
Query: 996 LECEIGEMYVVMKNAGLSGKEMT--AKTKLEKEIDEIRSKLSKND---SEFTNEKNRLQT 1050
E+ + + + E AK KL + E + + S K RLQT
Sbjct: 436 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 495
Query: 1051 EIAKLKDVNAKLEGDKDVFA---NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
E +DV +LE A K + LE Q + + E++ + + L +
Sbjct: 496 ES---EDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTE 552
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEV-GDK 1166
L L+ + + QV K Q+ K K + G+K
Sbjct: 553 LFR---LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK 609
Query: 1167 TK---KIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS 1223
++ + + RI+ +LS K V + L H+R
Sbjct: 610 SEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDE---ECANLRRNHQRAV 666
Query: 1224 IELTSEKD-ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE-- 1280
L + D E +AR K +E ++ DL+ + AA + QL+
Sbjct: 667 ESLQASLDAETRARNEALRLKK-KMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE 725
Query: 1281 ----DALRQTTNDKYDEATS--------PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
D ++ + +++A + E+ E+R + EL A +L
Sbjct: 726 QAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERL 785
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKL--------ENXXXXXXXXXXXXXXXSSYWENKAKEL 1380
++++ + +L++DLA+L + + E KE
Sbjct: 786 NLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ 845
Query: 1381 DTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEET 1440
DT ER K + + + ++AE A L+G K +++ + EL E ++
Sbjct: 846 DTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKH 905
Query: 1441 VKKL----EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELST 1496
+ L +H +++ Y+ + L + +V K + V+ + Q E +++ +T
Sbjct: 906 AEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE--EAEQQANT 963
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
L + + Q +L + +T+ A ++ L
Sbjct: 964 NLAKYRKAQHELDDAEERADMAETQANKLRARTRDAL 1000
Score = 51.6 bits (118), Expect = 3e-05
Identities = 90/433 (20%), Positives = 159/433 (36%), Gaps = 31/433 (7%)
Query: 1341 EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK 1400
E +LK D+ LE + LD + K+ ++ AH +
Sbjct: 18 ECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQ 77
Query: 1401 DVKNKDAE----LATLKGKLKILEQ--NSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+ + AE A K KL++ +Q + ++ +L+ + E +KLE L L +
Sbjct: 78 ALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQES 137
Query: 1455 YEELTGKYELLEE-----EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLG 1509
+ + LEE + +++ L VE EQ G +QK++ + L+E+L
Sbjct: 138 VADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGA--QMQKKIKELQARAEELEEELE 195
Query: 1510 TESAAW---NTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQREREL-RAANDRRDV 1565
E AA ++ E + L ERL G R R +RE EL R + +
Sbjct: 196 AERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCR--KREAELGRLRRELEEA 253
Query: 1566 LEHHHDXXXXXXXXXXXXXXDY-ERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
H + E+V +QR E +A
Sbjct: 254 ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRA 313
Query: 1625 EITDTKT--RYEGQMNTMRDELKSLHNQVS-------RFRRERDNYKQMLEAAQKSMAEI 1675
+ + K YE Q++ + +++ L Q++ R + E ++LE + ++++
Sbjct: 314 KASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQL 373
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLE--DELCESRLLASKLNTELVSEK 1733
G A + EEE + K AL A D L E ++ EL
Sbjct: 374 SRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLL 433
Query: 1734 SSAEVRLAEMQSR 1746
S A +A+ +S+
Sbjct: 434 SKANAEVAQWRSK 446
Score = 50.8 bits (116), Expect = 5e-05
Identities = 147/765 (19%), Positives = 284/765 (37%), Gaps = 51/765 (6%)
Query: 1054 KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
KL+D +L+ D D E E N+ K LTEEM + + +L+ + K +
Sbjct: 14 KLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKK---A 70
Query: 1114 LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKLLKEVGDKTKKIGD 1172
LQ + QV++ ++Q+K + K K GD
Sbjct: 71 LQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGD 130
Query: 1173 XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
+ ++ K + + + ++ A +++ EL + +E
Sbjct: 131 LKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIK-ELQARAEE 189
Query: 1233 LQARFIKTESKFITLEAEMRDLKADYENKITSLE---STIAAKDVHIKQLEDALRQTTND 1289
L+ + +E + + + E LE A + ++ E L + +
Sbjct: 190 LEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRE 249
Query: 1290 KYDEA-TSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
+ A + +R D L + KLEK E S ++E+ L ++
Sbjct: 250 LEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEK---EKSELRMEVDDLAAN 306
Query: 1349 LAKLENXXXXXXXXXXXXXXXSSYWENKAKELD---TDLQSERKKLDRMRIAHDKDVKNK 1405
+ L S + K +EL D ++R +L + ++ K
Sbjct: 307 VETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEK 366
Query: 1406 DAELATLKGKLKILEQNSGAGAKRITE---LKQEYEETVKKLEHSLALEKAEYEELTGKY 1462
+ ++ L + Q+ +++ E K V+ L H L + ++EE
Sbjct: 367 ECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQ 426
Query: 1463 ELLEEEHVVTKARLTVEKEQAQGELLHVQK--ELSTALGEIK-TLQE-KLGTESAAWNTE 1518
E + +++KA V + +++ E +Q+ EL A ++ LQE + G E+A N +
Sbjct: 427 --AELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAA--NAK 482
Query: 1519 KTEMQNSIASLQERLCGGGWEVERA-RLNARLDQRERELRAANDRRDVLEHHHDXXXXXX 1577
+ ++ + LQ E+ERA A LD+++R L A + R E
Sbjct: 483 CSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAA 542
Query: 1578 XXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQM 1637
+R S+ +++ K + EI+D Q+
Sbjct: 543 ----------QRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISD----LTDQV 588
Query: 1638 NTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEY 1697
+ ++ L E+ + LE A+ ++ E++ K+ RI S + E
Sbjct: 589 SLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL-ELEE-TKTLRIQLE--LSQVKAEV 644
Query: 1698 RNKVALLEQQVACL-EDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLL 1756
K+A +++ A L + L + L+ E + + ++ +M+ LN+ E +
Sbjct: 645 DRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLK-KKMEGDLNDLELQLGH 703
Query: 1757 SSGRARVAGLATRMELAWHKE----RDEQQRLLQETSTLARDLRQ 1797
++ +A A ATR+ A KE RDE+QRL E A+ L +
Sbjct: 704 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALER 748
Score = 48.4 bits (110), Expect = 3e-04
Identities = 103/437 (23%), Positives = 178/437 (40%), Gaps = 38/437 (8%)
Query: 1379 ELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYE 1438
E++ DL + R+KL+ KD+ D EL K + + +Q + K +TE +
Sbjct: 3 EVNADLAARRRKLEDECTELKKDI--DDLELTLAKAEKE--KQATENKVKNLTEEMAALD 58
Query: 1439 ETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGEL-LHVQKELST 1496
E+V +L + AL++A + L + +TKA+L +E++ E L +K+L
Sbjct: 59 ESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRM 118
Query: 1497 ALGEIKTLQE---KLGTESAA-WNTEKTEMQNSIASLQERLCGGGWEVERAR-LNARLDQ 1551
K E KL ES A +K +++ + L VE + L A++ +
Sbjct: 119 DTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQK 178
Query: 1552 RERELRA-ANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXX 1610
+ +EL+A A + + LE + E +S+
Sbjct: 179 KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRK 238
Query: 1611 XXXXI-----EQSEKARKAEITDTKTR---YEG------QMNTMRDELKSLHNQVSRFRR 1656
+ E E A + E T R EG Q+++++ + L + S R
Sbjct: 239 REAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRM 298
Query: 1657 ERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISST--DEEEYRNKVALLEQQVACLEDE 1714
E D+ +E ++ A + +K R + + +S EE + ++A Q L+ E
Sbjct: 299 EVDDLAANVETLTRAKA---SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTE 355
Query: 1715 LCE-SRLLASK--LNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRME 1771
E SRLL K L ++L K+ A L E++ +L EE + S+ V L +
Sbjct: 356 SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLE--EESKAKSALAHAVQALRHDCD 413
Query: 1772 L--AWHKERDEQQRLLQ 1786
L H+E E Q LQ
Sbjct: 414 LLREQHEEEAEAQAELQ 430
>AY480051-1|AAR95684.1| 4547|Homo sapiens plectin 11 protein.
Length = 4547
Score = 81.8 bits (193), Expect = 2e-14
Identities = 301/1601 (18%), Positives = 624/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 965 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1023
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1024 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1139
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R ++ R Q LA+ + +
Sbjct: 1140 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1258
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1259 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1311
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1312 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1364
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1365 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ EA R K ++L+A
Sbjct: 1479 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1596
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1767
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1768 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1824
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 1881
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 1999
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ ++ A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2057
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2058 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2102
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A ++R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2390
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Score = 74.5 bits (175), Expect = 3e-12
Identities = 243/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1373 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1491 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEE 1547
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1728 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1775
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 1893
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 1894 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 1951 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 2005
Query: 925 ATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+K + +A K L+ + +K+ + +K +
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2064
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A S +++ +L++ +E
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2305 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2422
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2423 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2479
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2538
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2653
Score = 68.1 bits (159), Expect = 3e-10
Identities = 239/1367 (17%), Positives = 527/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1400
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1521 VKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1575
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1756 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A++ + + A
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2167
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2168 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2406 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2461
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2512
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2566
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2567 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2624
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2625 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2669
Score = 65.3 bits (152), Expect = 2e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K + E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1631
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1752 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1805
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 1864
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 1922
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 1923 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + K++ R ++ + +L
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2156
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2337 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2386
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2387 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Score = 62.9 bits (146), Expect = 1e-08
Identities = 147/705 (20%), Positives = 288/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 1970
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+AK+ A L E
Sbjct: 1971 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2087
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2148 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2320
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2434
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2435 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2483
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2484 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2540
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2541 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2132 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2243
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2421 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2477
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2478 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2596 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
>AY480050-1|AAR95683.1| 4551|Homo sapiens plectin 10 protein.
Length = 4551
Score = 81.8 bits (193), Expect = 2e-14
Identities = 301/1601 (18%), Positives = 624/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 969 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1027
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1028 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1087
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1088 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1143
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R ++ R Q LA+ + +
Sbjct: 1144 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1203
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1204 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1262
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1263 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1315
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1316 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1368
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1369 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1426
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1427 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1482
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ EA R K ++L+A
Sbjct: 1483 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1600
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1771
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1772 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1828
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1829 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 1885
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1945
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 2003
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ ++ A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2061
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2062 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2106
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A ++R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2166
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2226
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2338
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2394
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2495
Score = 74.5 bits (175), Expect = 3e-12
Identities = 243/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1377 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1434
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1435 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1494
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1495 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEE 1551
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1552 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1611
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1731
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1732 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1779
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 1897
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 1898 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 1955 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 2009
Query: 925 ATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+K + +A K L+ + +K+ + +K +
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2068
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A S +++ +L++ +E
Sbjct: 2069 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2128
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2129 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2188
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2189 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2248
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2309 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2426
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2427 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2483
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2484 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2542
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2543 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2603 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2657
Score = 68.1 bits (159), Expect = 3e-10
Identities = 239/1367 (17%), Positives = 527/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1404
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1525 VKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1579
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1699
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1700 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1759
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1760 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1998
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A++ + + A
Sbjct: 1999 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2058
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2113
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2171
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2172 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2229
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2349
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2410 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2465
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2516
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2517 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2570
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2571 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2628
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2629 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2673
Score = 65.3 bits (152), Expect = 2e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K + E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1577
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1635
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1636 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1695
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1755
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1756 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1809
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 1868
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 1869 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 1926
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 1927 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1981
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + K++ R ++ + +L
Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2041
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2160
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2280
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2341 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2390
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2391 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2424
Score = 62.9 bits (146), Expect = 1e-08
Identities = 147/705 (20%), Positives = 288/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 1974
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+AK+ A L E
Sbjct: 1975 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2032
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2091
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2092 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2152 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2209
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2210 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2269
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2324
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2438
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2439 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2487
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2488 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2544
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2545 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2587
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2136 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2193
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2194 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2247
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2364
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2424
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2425 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2481
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2482 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2541 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2599
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2600 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2629
>AY480049-1|AAR95682.1| 4547|Homo sapiens plectin 8 protein.
Length = 4547
Score = 81.8 bits (193), Expect = 2e-14
Identities = 301/1601 (18%), Positives = 624/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 965 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1023
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1024 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1139
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R ++ R Q LA+ + +
Sbjct: 1140 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1258
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1259 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1311
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1312 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1364
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1365 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ EA R K ++L+A
Sbjct: 1479 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1596
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1767
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1768 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1824
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 1881
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 1999
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ ++ A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2057
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2058 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2102
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A ++R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2390
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Score = 74.5 bits (175), Expect = 3e-12
Identities = 243/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1373 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1491 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEE 1547
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1728 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1775
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 1893
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 1894 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 1951 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 2005
Query: 925 ATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+K + +A K L+ + +K+ + +K +
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2064
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A S +++ +L++ +E
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2305 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2422
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2423 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2479
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2538
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2653
Score = 68.1 bits (159), Expect = 3e-10
Identities = 239/1367 (17%), Positives = 527/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1400
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1521 VKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1575
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1756 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A++ + + A
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2167
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2168 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2406 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2461
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2512
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2566
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2567 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2624
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2625 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2669
Score = 65.3 bits (152), Expect = 2e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K + E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1631
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1752 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1805
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 1864
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 1922
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 1923 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + K++ R ++ + +L
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2156
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2337 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2386
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2387 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Score = 62.9 bits (146), Expect = 1e-08
Identities = 147/705 (20%), Positives = 288/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 1970
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+AK+ A L E
Sbjct: 1971 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2087
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2148 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2320
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2434
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2435 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2483
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2484 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2540
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2541 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2132 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2243
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2421 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2477
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2478 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2596 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
>AY480048-1|AAR95681.1| 4515|Homo sapiens plectin 7 protein.
Length = 4515
Score = 81.8 bits (193), Expect = 2e-14
Identities = 301/1601 (18%), Positives = 624/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 933 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 991
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 992 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1051
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1052 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1107
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R ++ R Q LA+ + +
Sbjct: 1108 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1167
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1168 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1226
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1227 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1279
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1280 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1332
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1333 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1390
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1391 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1446
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ EA R K ++L+A
Sbjct: 1447 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1564
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1735
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1736 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1792
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1793 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 1849
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 1850 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1909
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 1967
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ ++ A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2025
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2026 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2070
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A ++R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2130
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2190
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2191 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2250
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2302
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2358
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2459
Score = 74.5 bits (175), Expect = 3e-12
Identities = 243/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1341 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1398
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1399 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1458
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1459 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEE 1515
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1516 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1575
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1635
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1695
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1696 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1743
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 1861
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 1862 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 1919 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 1973
Query: 925 ATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+K + +A K L+ + +K+ + +K +
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2032
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A S +++ +L++ +E
Sbjct: 2033 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2092
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2093 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2152
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2153 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2212
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2213 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2273 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2390
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2391 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2447
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2448 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2506
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2507 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2567 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2621
Score = 68.1 bits (159), Expect = 3e-10
Identities = 239/1367 (17%), Positives = 527/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1368
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1489 VKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1543
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1663
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1664 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1723
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1724 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1962
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A++ + + A
Sbjct: 1963 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2022
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2077
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2135
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2136 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2193
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2313
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2374 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2429
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2430 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2480
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2481 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2534
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2535 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2592
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2593 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2637
Score = 65.3 bits (152), Expect = 2e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1363
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K + E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1541
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1599
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1600 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1659
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1719
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1720 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1773
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 1832
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 1833 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 1890
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 1891 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1945
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + K++ R ++ + +L
Sbjct: 1946 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2005
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2124
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2244
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2245 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2305 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2354
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2355 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2388
Score = 62.9 bits (146), Expect = 1e-08
Identities = 147/705 (20%), Positives = 288/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 1938
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+AK+ A L E
Sbjct: 1939 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 1996
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2055
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2056 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2116 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2173
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2174 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2233
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2288
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2402
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2403 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2451
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2452 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2508
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2509 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2551
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2100 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2157
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2158 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2211
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2328
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2388
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2389 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2445
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2446 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2505 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2563
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2564 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2593
>AY480047-1|AAR95680.1| 4684|Homo sapiens plectin 6 protein.
Length = 4684
Score = 81.8 bits (193), Expect = 2e-14
Identities = 301/1601 (18%), Positives = 624/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 1102 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1160
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1161 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1220
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1221 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1276
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R ++ R Q LA+ + +
Sbjct: 1277 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1336
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1337 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1395
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1396 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1448
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1449 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1501
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1502 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1559
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1560 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1615
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ EA R K ++L+A
Sbjct: 1616 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1733
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1904
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1905 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1961
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1962 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 2018
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 2019 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 2078
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 2136
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ ++ A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2194
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2195 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2239
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A ++R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2359
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2471
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2527
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2628
Score = 74.5 bits (175), Expect = 3e-12
Identities = 243/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1510 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1567
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1568 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1628 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEE 1684
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1685 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1744
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1864
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1865 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1912
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 2030
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 2031 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 2088 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 2142
Query: 925 ATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+K + +A K L+ + +K+ + +K +
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2201
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A S +++ +L++ +E
Sbjct: 2202 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2261
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2262 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2321
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2322 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2381
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2442 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2559
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2560 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2616
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2617 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2675
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2676 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2736 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2790
Score = 68.1 bits (159), Expect = 3e-10
Identities = 239/1367 (17%), Positives = 527/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1537
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1658 VKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1712
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1832
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1893 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2131
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A++ + + A
Sbjct: 2132 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2191
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2246
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2304
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2305 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2362
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2482
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2543 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2598
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2599 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2649
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2650 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2703
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2704 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2761
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2762 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2806
Score = 65.3 bits (152), Expect = 2e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1532
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K + E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1710
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1768
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1769 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1888
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1889 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1942
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 2001
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 2002 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 2059
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 2060 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2114
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + K++ R ++ + +L
Sbjct: 2115 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2174
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2293
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2413
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2414 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2474 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2523
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2524 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2557
Score = 62.9 bits (146), Expect = 1e-08
Identities = 147/705 (20%), Positives = 288/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 2107
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+AK+ A L E
Sbjct: 2108 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2165
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2224
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2225 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2285 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2343 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2402
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2457
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2571
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2572 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2620
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2621 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2677
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2678 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2720
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2269 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2326
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2327 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2380
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2497
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2557
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2558 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2614
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2615 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2674 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2732
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2733 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2762
>AY480046-1|AAR95679.1| 4525|Homo sapiens plectin 3 protein.
Length = 4525
Score = 81.8 bits (193), Expect = 2e-14
Identities = 301/1601 (18%), Positives = 624/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 943 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1001
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1002 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1061
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1062 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1117
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R ++ R Q LA+ + +
Sbjct: 1118 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1177
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1178 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1236
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1237 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1289
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1290 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1342
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1343 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1400
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1401 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1456
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ EA R K ++L+A
Sbjct: 1457 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1574
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1745
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1746 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1802
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1803 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 1859
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 1860 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1919
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 1920 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 1977
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ ++ A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2035
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2036 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2080
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A ++R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2200
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2201 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2260
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2312
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2368
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2469
Score = 74.5 bits (175), Expect = 3e-12
Identities = 243/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1351 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1408
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1409 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1468
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1469 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEE 1525
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1526 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1585
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1586 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1645
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1705
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1706 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1753
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 1871
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 1872 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 1929 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 1983
Query: 925 ATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+K + +A K L+ + +K+ + +K +
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2042
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A S +++ +L++ +E
Sbjct: 2043 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2102
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2103 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2162
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2163 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2222
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2283 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2400
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2401 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2457
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2516
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2517 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2577 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2631
Score = 68.1 bits (159), Expect = 3e-10
Identities = 239/1367 (17%), Positives = 527/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1378
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1499 VKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1553
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1673
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1674 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1734 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1912
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1972
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A++ + + A
Sbjct: 1973 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2032
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2087
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2145
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2146 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2203
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2264 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2323
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2384 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2439
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2440 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2490
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2491 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2544
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2545 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2602
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2603 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2647
Score = 65.3 bits (152), Expect = 2e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1373
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K + E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1551
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1609
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1610 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1729
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1730 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1783
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 1842
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 1843 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 1900
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 1901 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1955
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + K++ R ++ + +L
Sbjct: 1956 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2015
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2134
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2254
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2255 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2315 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2364
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2365 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2398
Score = 62.9 bits (146), Expect = 1e-08
Identities = 147/705 (20%), Positives = 288/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 1948
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+AK+ A L E
Sbjct: 1949 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2006
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2065
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2066 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2126 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2184 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2243
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2298
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2412
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2413 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2461
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2462 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2518
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2519 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2561
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2110 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2167
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2168 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2221
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2338
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2398
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2399 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2455
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2456 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2515 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2573
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2574 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2603
>AY480045-1|AAR95678.1| 4533|Homo sapiens plectin 2 protein.
Length = 4533
Score = 81.8 bits (193), Expect = 2e-14
Identities = 301/1601 (18%), Positives = 624/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 951 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1009
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1010 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1069
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1070 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1125
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R ++ R Q LA+ + +
Sbjct: 1126 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1185
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1186 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1244
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1245 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1297
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1298 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1350
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1351 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1408
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1409 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1464
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ EA R K ++L+A
Sbjct: 1465 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1523
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1582
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1753
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1754 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1810
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1811 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 1867
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 1868 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1927
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 1928 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 1985
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ ++ A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2043
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2044 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2088
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A ++R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2148
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2208
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2209 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2268
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2320
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2376
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2477
Score = 74.5 bits (175), Expect = 3e-12
Identities = 243/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1359 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1416
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1417 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1476
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1477 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEE 1533
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1534 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1593
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1594 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1653
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1713
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1714 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1761
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 1879
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 1880 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 1937 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 1991
Query: 925 ATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+K + +A K L+ + +K+ + +K +
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2050
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A S +++ +L++ +E
Sbjct: 2051 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2110
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2111 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2170
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2171 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2230
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2231 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2290
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2291 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2408
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2409 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2465
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2466 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2524
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2525 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2585 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2639
Score = 68.1 bits (159), Expect = 3e-10
Identities = 239/1367 (17%), Positives = 527/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1386
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1507 VKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1561
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1681
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1682 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1741
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1742 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1920
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1980
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A++ + + A
Sbjct: 1981 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2040
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2095
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2096 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2153
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2154 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2211
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2272 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2331
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2392 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2447
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2448 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2498
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2499 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2552
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2553 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2610
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2611 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2655
Score = 65.3 bits (152), Expect = 2e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1381
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K + E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1559
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1617
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1618 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1677
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1737
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1738 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1791
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 1850
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 1851 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 1908
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 1909 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1963
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + K++ R ++ + +L
Sbjct: 1964 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2023
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2142
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2262
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2263 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2322
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2323 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2372
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2373 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2406
Score = 62.9 bits (146), Expect = 1e-08
Identities = 147/705 (20%), Positives = 288/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 1956
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+AK+ A L E
Sbjct: 1957 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2014
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2073
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2074 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2134 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2191
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2192 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2251
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2306
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2367 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2420
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2421 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2469
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2470 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2526
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2527 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2569
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2118 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2175
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2176 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2229
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2346
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2406
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2407 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2463
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2464 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2523 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2581
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2582 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2611
>AY480044-1|AAR95677.1| 4574|Homo sapiens plectin 1 protein.
Length = 4574
Score = 81.8 bits (193), Expect = 2e-14
Identities = 301/1601 (18%), Positives = 624/1601 (38%), Gaps = 152/1601 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA-NIDTANKYTTGRSSEVLK-LQQKV 326
YQ ++ L+Q RC+R E DI L+ A T ++ E + Q++
Sbjct: 992 YQQLLQSLEQGAQE-ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1050
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
E ++ K + + E E L E P+ ++E KL +L
Sbjct: 1051 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1110
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+++ + + +R ++ + E+Q E ++ L + S K + +
Sbjct: 1111 YLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPEL--EATKASLKKLRAQA 1166
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
+A Q + E + + VG + R E+E+ R ++ R Q LA+ + +
Sbjct: 1167 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1226
Query: 504 TGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
++ E+ + L +++ Q + L DS LR++ EE
Sbjct: 1227 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM-PLADSQAVREQLRQEQALLEEI 1285
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+ ++V KQ + +E + VT Q + ++P+ K K S S
Sbjct: 1286 ERHGEKVEECQRFAKQYIN----AIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1338
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + + H+ L+ + +T R+EE+ +L + +L+
Sbjct: 1339 VIQEYVDLRTHYS--ELTTLTSQYIKFISETLRRMEEEE-----RLAEQQRAEERERLAE 1391
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
A + + A + + + +A+ E K L + ++E + +Q K ++++++
Sbjct: 1392 VEAALEKQRQLAEAHAQAKA-QAE-REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1449
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE-RVKVLEDEIDEVRKKLIEKERDCE 801
++L + + A A RS ++ EE RV L+ E E ++ E E
Sbjct: 1450 QQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV-----IEQEASVLRAKTQSLEA 856
R AE + AQK+ + ++ L Q KRQ +V ++ EA R K ++L+A
Sbjct: 1506 RARAEEAEAQKR-QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
Query: 857 DNE-KLQTENKKLQL----LKNAKSL--------RSDKALDLNTK------KTTQLENEL 897
E +LQ E + +L ++ A+ + RS +A +L +K KT QLE L
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-ELQSKRASFAEKTAQLERSL 1623
Query: 898 KE---ALAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+E A+A+++E E Q + ++ R E ++E + + K
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAR--EEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
QA + K++A++ + R K + +L + + + ++ E + A
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 1014 GK-EMTAKTKLEKE----IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ A+T+ ++ ++E ++L + + T ++ L+ E+AK V A++E +
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK---VRAEMEV---L 1794
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXX 1128
A+K +A E E+ + S + K E R ++ + +A L+ +
Sbjct: 1795 LASKARA-EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDA 1851
Query: 1129 XXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIE 1188
+ T++ + LKE + +++ +R+E
Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR---RRLE 1908
Query: 1189 KQLSTRK----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+Q + K +R+ + L R ++ E L+A F K +
Sbjct: 1909 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1968
Query: 1245 ITLEAEMRDLKADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE E+ ++++ E+ + S E AA+ + E+ R+ ++ ++ + E E
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE--E 2026
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
+ ++ A+ E+ E ES A +L++AQ ++ +L+
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQES-ARQLQLAQ-EAAQKRLQAEEKAHAFA 2084
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ K +EL LQ E+ LD++R + + + AE A + ++ +
Sbjct: 2085 V----------QQKEQELQQTLQQEQSVLDQLR--GEAEAARRAAEEAE---EARVQAER 2129
Query: 1423 SGAGAKRITE----LKQEYEETVK-KLEHSLALEKA--EYEELTGKYELLEEEHVVTK-- 1473
A ++R E LKQ EE + + + A EK E E+ + E+ + K
Sbjct: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
Query: 1474 ARLTVEK-----EQAQGELLHVQKELSTA---LGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
A +EK EQ + V++EL+T L E + L E E TE
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249
Query: 1526 IASLQERLCGGGWEVER-ARLNARLDQREREL--RAANDRRDVLEHHHDXXXXXXXXXXX 1582
+ ++E L ++E ++L AR++ R L R ++ + L+ +
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRD 1642
+ +++++ + + K + TR + + ++
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQQ 2361
Query: 1643 ELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVA 1702
+ + Q R + +++ Q L + ++ ++ S + E + +VA
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM----SAEAERLKLRVA 2417
Query: 1703 LLEQQVACLEDELCESRLLASKLN-----TELVSEKSSAEVRLAEMQSRLNEYEEERL-- 1755
+ + A E++ R A ++ TEL +++ V+ E+Q + ++++ ERL
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 1756 ----LSSGRARVAGLATRMEL-AWHKERDEQQRLLQETSTL 1791
L + ++ A ++L + + +Q++LLQET L
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2518
Score = 74.5 bits (175), Expect = 3e-12
Identities = 243/1317 (18%), Positives = 507/1317 (38%), Gaps = 119/1317 (9%)
Query: 300 RRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE----DLRDEKKHLTQKIREI----E 351
R+LA K R E +LQQ++ E E D + +K+ + ++++++ E
Sbjct: 1400 RQLAEAHAQAKAQAER--EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457
Query: 352 SELETRP-STEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
+E++ + EA R ++ ++ E + + EL+ L + R
Sbjct: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
+ Q +E LRR+++ + R +L + + +EK + L E+ +
Sbjct: 1518 QAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEE 1574
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEA-----NSKFTGSNPSLMKVPQPETVKVS--R 523
E R+++ E E AR +VAL + AEA + F L + Q E V V+ R
Sbjct: 1575 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634
Query: 524 SSLTRGGSQEDPAQLLR-DLQDSLER---EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
R Q+ A+ R + + LER +A+ +LR EE A K + ++
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694
Query: 580 MTD-------NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
+ + + E ++ + A T + ++ + + TE+ +
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
L + +A L++ AA + + L +L K+ +A L A+K E
Sbjct: 1755 QRQL----LEEELA--RLQREAAAATQKRQELEAELAKV--RAEMEVLL----ASKARAE 1802
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
+ + +++ + AE EL E EA LR EE ++ ++ ++ ++ V
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 753 TKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ A R T L E ER++ L ++ + +++ +E++ + E
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAAQHKADIEE 1920
Query: 808 SLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK 867
LAQ + + L+ D RQ + +E+E L+A + A +L+ E +
Sbjct: 1921 RLAQLRKAS---DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Query: 868 LQLLKNAK-SLRSDKALDLNTKKTTQL--ENELKEALAKIKELEMICQDEKSEKKVRFTE 924
++ NA+ +LRS + +L + QL E E + A+ + + + +E++ R +
Sbjct: 1978 IR--SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA---ARQRK 2032
Query: 925 ATKKETDTLKSK--QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
A +E + LK+K + +A K L+ + +K+ + +K +
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE-EKAHAFAVQQKEQE 2091
Query: 983 LTTKLQLKKMVEDL---ECEIGEMYV---------VMKNAGLSGKEMTAKTKLEKEIDE- 1029
L LQ ++ V D E E + A S +++ +L++ +E
Sbjct: 2092 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2151
Query: 1030 --IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE----NENSNL 1083
R++ + E + A+ + + + D K+K + + +
Sbjct: 2152 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2211
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLK--NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXX 1141
+ TL +++ + Q N L +L+ A + +
Sbjct: 2212 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2271
Query: 1142 XXXQVDNYTKIDQDKN---KLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
+ +N I +DK+ + L+E +K K++ + R+ + +
Sbjct: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL---QARFIKTESKFI---------- 1245
QAV A T + EL ++ EL QAR ++ + + +
Sbjct: 2332 RALAEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390
Query: 1246 ---TLEAE-MRDLKADYENKITSLESTIAAKDVHIKQLEDALR-QTTNDKYDEATSPVEM 1300
TLEAE R L+ E + L ++ + EDA R + ++ E E+
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRVAEMSR-AQARAEEDAQRFRKQAEEIGEKLHRTEL 2449
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
Q + + +++ E E KL Q ++ L +L++
Sbjct: 2450 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL---QQEAKLLQLKSEEMQTV 2506
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+ ++ E D+ LQ ER +++ + ++ +++ A+ L+ + + +
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRER-FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2565
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL----TGKYELLEEEHVVTKARL 1476
Q +R+ +E + E + ++ E ++L + ELL EE+ + +L
Sbjct: 2566 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
+ +EQ + L H ++ ++ + KTL G ++ + E ++S L+ ++
Sbjct: 2626 QLLEEQHRAALAHSEEVTASQVAATKTLPN--GRDALDGPAAEAEPEHSFDGLRRKV 2680
Score = 68.1 bits (159), Expect = 3e-10
Identities = 239/1367 (17%), Positives = 527/1367 (38%), Gaps = 104/1367 (7%)
Query: 469 MQRENRIKEL----EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS 524
M+ E R+ E E+E E AL QR+LAEA+++ K Q ++
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQEE 1427
Query: 525 SLTRGGSQEDPAQLLRDLQDSLER-----EADLREQLRNAEEETANCKQVNPPTFLDKQV 579
+ R + D Q R +Q+ L++ EA+++ + R AE + ++ + +
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 580 MTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL 639
+ E E + + A + +E D++ + Q +L
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1547
Query: 640 SIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE 699
AA ++ +EE L LQ ++ + R ++ ++++ETA + E
Sbjct: 1548 VKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERARQV-QVALETAQRSAE 1602
Query: 700 KE--TDEADPAEMKLLLELNEQEATV----LRRKVE-------ELEQDKEALKKQVKELT 746
E + A AE LE + QE V LR + E E E+ +E +++++
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 747 SKISSVTKTSAGSNTTAR-RSLT-TNSNKLAEERVKVL----EDEIDEVRKK-LIEKERD 799
K + + + A+ +SL + K EE + + E VR++ L E+E +
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
Query: 800 CERLHAELSLAQK--KPKTLIKSRS-LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+R AE + Q+ + LI+ R+ + +QQ L+ +L +++EA+ K Q LEA
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE-NELKEALAKIKELEMICQDEK 915
+ K++ E + L L A++ ++ +K+ + E +E + L + ++ K
Sbjct: 1783 ELAKVRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 916 SEKKVRFTEATKKETD---TLKSKQXXXXXXXXXXXXXXXXXXXXQA---TLKSLKDD-- 967
++++ +A ++ + L K +A L+ L +D
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 968 -AQKSFKPRIPKKPTDLTTKL-QLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTA-KTKL 1023
++ + + + D+ +L QL+K + +LE + G + ++ +E+ A K
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961
Query: 1024 EK------EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
EK E++ ++ N + K + + E A+ + + A+ E + + +
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2021
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ Q K EE++ +A++ + + A
Sbjct: 2022 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2081
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK-RIEKQLSTRKD 1196
+ + + Q+++ L D+ + + + + E++ + +
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVL-----DQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2136
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+V QA A + + +L E ++ AR + E + + + D +
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALR-QKQAADAEM 2194
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
+ K E T+ K ++L Q + + E+ ++
Sbjct: 2195 EKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2252
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLE-MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++EL + ++++E+ + + E A + D + ++
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNK---DAELATLKGKLKILEQNSGAGAKRITE 1432
A+E Q + L + R +K +K K E LK + ++L+Q ++
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 1433 LKQEYEETVKKL-EHSLALEKAEYEELTGKYEL-LEEEHVVTK-ARLTVEKEQAQGELLH 1489
L+++ E+ ++L E + ++ E + E+ E E + + A ++ + +A+ +
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+K+ + +GE K + +L T+ + E+Q + ERL E+ER + +
Sbjct: 2433 FRKQ-AEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK--EK 2488
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q + L+ ++ ++ E+ S +QR
Sbjct: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS---EKDSLLQR------ERFIEQE 2539
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ Q E A+ ++ + + R + QM R L + + R + E + E
Sbjct: 2540 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE------EGV 2593
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ---VACLEDELCESRLLASKL 1725
++ E++ ++ R + + + + + R ++ LLE+Q +E+ S++ A+K
Sbjct: 2594 RRKQEELQQLEQQRR-QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK- 2651
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMEL 1772
L + + + + AE + + R +S+ R + AG+ + EL
Sbjct: 2652 --TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2696
Score = 65.3 bits (152), Expect = 2e-09
Identities = 189/1118 (16%), Positives = 410/1118 (36%), Gaps = 70/1118 (6%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L + E+E +++ EE E+ E V+ K + + A + A R
Sbjct: 1368 LRRMEEEERLAEQQRAEERERLAE-----VEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422
Query: 773 KLAEERVKVLEDEID-EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
++ EE V+ E +D + +K+ I++E R +E + K + RS +++
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Query: 832 DLKRQLQVIEQ-------EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA-- 882
++ QL+ E+ E LRA+ + EA + Q E ++L+ +S R +A
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 883 -LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L K + E + AL ++EL + Q E++E+++R E + + +
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRL--QAEEAERRLRQAEVERARQVQVALETAQRS 1600
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+SL+++ + R + + + ++ E+ E E+
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-EEAERRAQQQAEAERAREEAEREL- 1658
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE-FTNEKNRLQTEIAKLKDV-N 1059
E + + N L + + +K + + ++ K ++E + + + + + +++
Sbjct: 1659 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
Query: 1060 AKLEGDKDV---FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE + + A + A E E L + + ++ + E ++ +L + AT +
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1778
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + ++ + ++ K +L E G + +++ +
Sbjct: 1779 ELE-----AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAAR 1832
Query: 1177 XXXXXXXCKR----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDE 1232
KR E+ + ++ +A L T ++++ ++E
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KTEAEIALKEKEAENE 1891
Query: 1233 LQARFIKTES-KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL-EDALRQTTNDK 1290
R + E+ + LE + KAD E ++ L ++ K L ED LRQ +
Sbjct: 1892 RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ--RRQ 1949
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
+E E++ ++ + EL + E T A+LE A+ + A
Sbjct: 1950 VEE-----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2004
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL- 1409
+ E + K +++ + K++ R ++ + +L
Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2064
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
+ K L+ A A + + +QE ++T+++ + L + E E E EE
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
Query: 1470 VVTKARLTVEKEQAQ--GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V + + Q + L +E + A + + EKL E+ + + + + A
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-A 2183
Query: 1528 SLQERLCGGGWEVERARLNARLDQR---ERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
Q++ E + L Q+ E+EL + + +H +
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ R IE +A D R+ + ++
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2303
Query: 1645 KSLHNQVSRFRRERDNYKQMLE---AAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
++S +E +Q+ E A Q+++AE +K + + + E + +
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN-EYEEERLLSSGR 1760
L ++Q L++ + +A +L E + + E AE Q +L E ERL +
Sbjct: 2364 ELAQEQARRLQE---DKEQMAQQLAEETQGFQRTLE---AERQRQLEMSAEAERL----K 2413
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
RVA M A + ++ QR ++ + L +T
Sbjct: 2414 LRVA----EMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Score = 62.9 bits (146), Expect = 1e-08
Identities = 147/705 (20%), Positives = 288/705 (40%), Gaps = 67/705 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ- 324
V++ Q +++E+ L+ E+ K+++ L L I +N T RS E +L+
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE-LGRI-RSNAEDTLRSKEQAELEAA 1997
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +L E R E + QK + +E E +A ++E+L+AK+ A L E
Sbjct: 1998 RQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2055
Query: 385 MDEN--------EDMKKELRD--------LXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
E+ E +K L+ + +Q +++Q+ LR E E
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS-VLDQLRGEAEAAR 2114
Query: 429 KNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQR---ENRIKELEQEVA 483
+ + ER+A Q + E+AE K+ E + E KE EQE A
Sbjct: 2115 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 484 R---STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
R + + ALR Q++ A+A + + + Q V+ ++L + D + L
Sbjct: 2175 RRAQAEQAALR-QKQAADAEME-KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
Query: 541 DLQ-DSLEREA-DLREQLRNAEEETANCK-QVNPPTFLDKQVMTDN--IVTCDIHESETV 595
D + L+ EA + Q EEE + + Q+ + L ++ +N ++ D ++
Sbjct: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTA 654
KM A + + + + EE DL ++ M ++
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAVQ 2347
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKL 712
E+ LLQ +K + ++R+L A +L+ ET E + EM
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
E + + R E+D + +KQ +E+ K+ T+ + T ++L
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-TELATQEKVTLVQTL----- 2461
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
E + + + + + +R+ + E ER+ E+L E L Q +KS + Q+
Sbjct: 2462 ---EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE--Q 2510
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
L ++ Q ++Q S L K L+ + ++ E KL+ L + ++ + + ++ Q
Sbjct: 2511 LLQETQALQQ--SFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ 2567
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+E E + +A ++E + ++E+ VR + ++ + + +Q
Sbjct: 2568 MEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQQ 2610
Score = 37.9 bits (84), Expect = 0.37
Identities = 96/510 (18%), Positives = 211/510 (41%), Gaps = 40/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN--IDTANKYTTGRSSEVLKLQQKVN 327
Q E L++E + ++ R + E++ + ++ A+ ++ K+ + +++Q++
Sbjct: 2159 QAAAEKLRKEAE--QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
L E+ +K L ++++ +++E +TEA RQ Q+ +L + EEL
Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAE-----ATEA-ARQRSQVEEELFSVRVQMEELSKL 2270
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE------QTIKNCRVLSFK-LKK 440
++ E R L F +++A++ + E Q R L+ + L +
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST-EVALRLQRELAEA 499
A+++ +EK + ++ + + +Q++ KEL QE AR E ++ ++LAE
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEE 2387
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
F + + + + + R L A+ D Q ++ ++ E+L
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E T ++V L+ Q + + E+ + K+ A K + +
Sbjct: 2448 ELATQ--EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQ 2504
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEE---DNESLLLQLKK---- 670
+ ++ +ETQ +LS + + + + A++E+ D + QL++
Sbjct: 2505 TVQQEQLLQETQA-LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563
Query: 671 ---MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL--ELNEQEATVLR 725
+ R R ++ A + E A + ++ +E E + EL +E LR
Sbjct: 2564 QQQQMEQERQRLVASMEEARRRQHE-AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2622
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKT 755
+++ LE+ A +E+T+ + TKT
Sbjct: 2623 EQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
>AL133324-2|CAI19310.2| 1983|Homo sapiens myosin, heavy chain 7B,
cardiac muscle, beta protein.
Length = 1983
Score = 81.8 bits (193), Expect = 2e-14
Identities = 178/909 (19%), Positives = 365/909 (40%), Gaps = 67/909 (7%)
Query: 190 ERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKN----SRNSTNLKPPVRGGPXXX 245
E++ L S E EK R ER+ K + + + ++ +++ L+ ++
Sbjct: 1077 EQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 1136
Query: 246 XXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDIL--LRRLA 303
+ +KE Q + E L++E++ R RVEK++++ L L+
Sbjct: 1137 SQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELS 1196
Query: 304 -NIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEA 362
++ A + G+ K + ++ L E+ + +R + E
Sbjct: 1197 ERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALR--RKQAEGAAELGE 1254
Query: 363 QTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSL 420
Q ++++R KL E EL E +D+ + L + R EDQ E
Sbjct: 1255 QVDSLQRVRQKL---EKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIK 1311
Query: 421 RRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKEL 478
EL++ + + +L+ + +L +EK E + ++ G E ++L
Sbjct: 1312 VEELQRQLADASTQRGRLQTESGELSRLLEEK---ECLISQLSRGKALAAQSLEELRRQL 1368
Query: 479 EQEVARSTEVALRLQR------ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ 532
E+E + +A +Q L E + + + L ++ +V++ R +
Sbjct: 1369 EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQ---WRSKYE 1425
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
D Q +L+++ ++ A LR Q E AN K + L+K + + T ES
Sbjct: 1426 ADAIQRTEELEEAKKKLA-LRLQEAEEGVEAANAK----CSSLEKAKL--RLQT----ES 1474
Query: 593 ETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRK 652
E VT ++ + AA+ K++ L ++ +E + +L + L +
Sbjct: 1475 EDVTLELE-RATSAAAALDKKQRHLERALE-ERRRQEEEMQRELEAAQRESRGLGTELFR 1532
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE-KETDEADPAEMK 711
EE E+ L+ K K ++S LS ++ + ++ K+ E + +E++
Sbjct: 1533 LRHGHEEALEA--LETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ 1590
Query: 712 LLLE-----LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS 766
LE L +E LR ++ EL Q K + +++ E + +++ + + + + S
Sbjct: 1591 AALEEAEGALELEETKTLRIQL-ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQAS 1649
Query: 767 L--TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
L T + A K +E +++++ +L R A L Q + K + D
Sbjct: 1650 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKE--EQAGRD 1707
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA-----DNEKLQTENKKLQLLKNAKSLRS 879
+ +L Q Q +E+ AS+L A+ + L A + + E + L+ + L S
Sbjct: 1708 EEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHS 1767
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXX 939
LN KK +LE +L + +++E ++ + + K T+A + LK +Q
Sbjct: 1768 QNTGLLNQKK--KLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMM-AEELKKEQDT 1824
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPK---KPTDLTTKL--QLKKMVE 994
QA L+ + A + K ++ K K +L +L + KK E
Sbjct: 1825 SAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 1884
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
L+ V + A + ++ +++ +D+++SK+ +F + + T +AK
Sbjct: 1885 ALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAK 1944
Query: 1055 LKDVNAKLE 1063
+ +L+
Sbjct: 1945 YRKAQHELD 1953
Score = 78.2 bits (184), Expect = 3e-13
Identities = 186/835 (22%), Positives = 351/835 (42%), Gaps = 96/835 (11%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
K++ + + A ++ LR L AAE +EL + + + +E DL
Sbjct: 884 KMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAE 943
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER-KAD------QLEQEKAEHEK- 457
QDN D + L + Q + LS +L+ E AD +LE E E +K
Sbjct: 944 QDNL-ADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKD 1002
Query: 458 ----KLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE---LAEANSKFTGSNPSL 510
KL + EN++K L +E+A E RL +E L EA+ + G
Sbjct: 1003 IDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGD---- 1058
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
Q E +V S+LT+ + + Q + DL+ SLE+E LR A+ + ++
Sbjct: 1059 ---LQAEEDRV--SALTKAKLRLE--QQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLT 1111
Query: 571 PPTFL----DKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKT 626
+ DKQ + + + D E ++ ++++ + A ++ + +++
Sbjct: 1112 QESVADAAQDKQQLEEKLKKKD-SELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEE 1170
Query: 627 TEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPA 686
E + + AA L + + R+EE + Q + + R +L
Sbjct: 1171 LEAER--AARARVEKQRAEAARELEELSERLEEAGGASAGQ--REGCRKREAELGRL--- 1223
Query: 687 NKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELT 746
+ +E A E + + EL EQ L+R ++LE++K L+ +V +L
Sbjct: 1224 -RRELEEAALRHEATVAALRRKQAEGAAELGEQ-VDSLQRVRQKLEKEKSELRMEVDDLA 1281
Query: 747 SKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLH-- 804
+ + ++T+ A + R T ++L+E ++KV +E++++L + RL
Sbjct: 1282 ANVETLTRAKASAEKLCR----TYEDQLSEAKIKV-----EELQRQLADASTQRGRLQTE 1332
Query: 805 -AELSLAQKKPKTLIK--SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
ELS ++ + LI SR + Q +L+RQL+ + S L Q+L D + L
Sbjct: 1333 SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLL 1392
Query: 862 ----------QTENKKLQLLKNAK--SLRSDKALDLNTKKTTQLENELKEALAKIKELE- 908
Q E ++L NA+ RS D ++T +LE K+ +++E E
Sbjct: 1393 REQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADA-IQRTEELEEAKKKLALRLQEAEE 1451
Query: 909 -MICQDEK--SEKKVRFTEATKKETDTLKSKQXXXXXXX-----XXXXXXXXXXXXXQAT 960
+ + K S +K + T+ E TL+ ++ +
Sbjct: 1452 GVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEE 1511
Query: 961 LKSLKDDAQKSFKP------RIPKKPTDLTTKLQ-LKKMVEDLECEIGEMYVVMKNAGLS 1013
++ + AQ+ + R+ + L+ LK+ ++L+ EI ++ + +G S
Sbjct: 1512 MQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKS 1571
Query: 1014 GKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEKN---RLQTEIAKLK-DVNAKL-EGDKD 1067
+E+ K LE E EI++ L + + E+ R+Q E++++K +V+ KL E D++
Sbjct: 1572 IQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEE 1631
Query: 1068 ---VFANKYKALENENSNLSNQCKTLTEEM---KNREAQINKLSADLKNATSLQT 1116
+ N +A+E+ ++L + + E + K E +N L L +AT T
Sbjct: 1632 CANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAT 1686
Score = 72.9 bits (171), Expect = 1e-11
Identities = 171/899 (19%), Positives = 347/899 (38%), Gaps = 86/899 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKT-- 755
DE + D ++KL L E+E KV+ L ++ AL + V LT + ++ +
Sbjct: 994 DECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 1053
Query: 756 SAGSNTTA---RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQK 812
A + A R S T + E++V+ LE +++ +K ++ ER +L +L L Q+
Sbjct: 1054 QALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 1113
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
S+ + Q L+ +L+ + E S L + + + ++Q + K+LQ
Sbjct: 1114 ---------SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ--- 1161
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD- 931
A++ ++ L+ ++E + EA +++EL ++ + K+E +
Sbjct: 1162 -ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAEL 1220
Query: 932 -TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
L+ + A + D+ + + ++ K+ K +L+
Sbjct: 1221 GRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKE------KSELR 1274
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSK---LSKNDSEFTNEKNR 1047
V+DL + + +A E +T E ++ E + K L + ++ + ++ R
Sbjct: 1275 MEVDDLAANVETLTRAKASA-----EKLCRT-YEDQLSEAKIKVEELQRQLADASTQRGR 1328
Query: 1048 LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
LQTE +L + LE + + + + +L + L EE K + A + + A
Sbjct: 1329 LQTESGELSRL---LEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA- 1384
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKLLKEVGDK 1166
L++ L + +V + +K + D + +E+ +
Sbjct: 1385 LRHDCDLLREQHE------EEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEA 1438
Query: 1167 TKKIG----DXXXXXXXXXXXCKRIEK---QLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
KK+ + C +EK +L T + VT
Sbjct: 1439 KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHL 1498
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R E +++E+Q + + L E+ L+ +E + +LE+ +K+
Sbjct: 1499 ERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALET--------LKRE 1550
Query: 1280 EDALRQTTNDKYDEAT-SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAA 1338
L++ +D D+ + S + E+ Q L A+ LE E ++
Sbjct: 1551 NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRI 1610
Query: 1339 KLEMAQLKSDL-----------AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
+LE++Q+K+++ A L + N+A L ++ +
Sbjct: 1611 QLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGD 1670
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
L+ +++ H + +A+ AT + ++ E+ +G ++ L E E + LE
Sbjct: 1671 LNDLE-LQLGH-ATRQATEAQAATRLMQAQLKEEQAGRDEEQ--RLAAELHEQAQALERR 1726
Query: 1448 LALEKAEYEELTGKYE-------LLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE 1500
+L AE EEL E L E+E + RL + Q G LL+ +K+L L +
Sbjct: 1727 ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG-LLNQKKKLEADLAQ 1785
Query: 1501 IK-TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
+ ++E A K + ++ +E R+ L+Q REL+A
Sbjct: 1786 LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQA 1844
Score = 71.7 bits (168), Expect = 2e-11
Identities = 175/886 (19%), Positives = 356/886 (40%), Gaps = 110/886 (12%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTGRSSEVL 320
++ +D+ LK+++D L+ + EKEK L +A +D + T +
Sbjct: 990 RKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1049
Query: 321 KL-QQKVNELTTHNE---DLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIE-QLR 371
+ QQ + +L + L K L Q++ ++E LE R TE R++E L+
Sbjct: 1050 EAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLK 1109
Query: 372 AKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDN-----FREDQADEYSSLRRELEQ 426
+ ++ E +KK+ +L ++D + + E + ELE+
Sbjct: 1110 LTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEE 1169
Query: 427 TIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST 486
++ R +++K +A + +E +E LE GG QRE ++ E E+
Sbjct: 1170 ELEAERAARARVEKQRAEAARELEELSER----LEEAGGASAGQREG-CRKREAELG--- 1221
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL 546
RL+REL EA + + +L + ++ G Q D Q +R L
Sbjct: 1222 ----RLRRELEEAALRHEATVAALRRKQAEGAAEL--------GEQVDSLQRVR---QKL 1266
Query: 547 EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ----NK 602
E+E + +LR ++ A N T + + + C +E + I+ +
Sbjct: 1267 EKE---KSELRMEVDDLA----ANVETLTRAKASAEKL--CRTYEDQLSEAKIKVEELQR 1317
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ AST + +++S LS + EE + + LS +AA +L + ++EE+++
Sbjct: 1318 QLADASTQRGRLQTESGELS--RLLEEKECL--ISQLSRGKALAAQSLEELRRQLEEESK 1373
Query: 663 S----------------LLLQLKKMATKARS--RKLSPTPPANKLSIETANDNDE-KETD 703
+ LL + + +A++ ++L A + + D + T+
Sbjct: 1374 AKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTE 1433
Query: 704 EADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
E + A+ KL L L E E V K LE+ K L+ + +++T ++ T +A +
Sbjct: 1434 ELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDK 1493
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
R + + EER + + +E++++L +R+ L EL + + ++
Sbjct: 1494 KQR-----HLERALEERRR----QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE-- 1542
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
+L+ ++N +L+ ++ + + S+ Q LE + L+ E ++Q A ++
Sbjct: 1543 ALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ----AALEEAEG 1598
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
AL+L KT +++ EL + A++ + +EK + ++S Q
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDR-------KLAEKDEECANLRRNHQRAVESLQASLD 1651
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ L L + Q R + T +Q + E +
Sbjct: 1652 AETRARNEALRLKKKMEGDLNDL--ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE 1709
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
+ + E A + L E++E+R+ L + + + L +L ++++
Sbjct: 1710 QRLAAELHEQAQALERRA-SLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1768
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
G N+ K LE + + LS + + +E + E + K D
Sbjct: 1769 NTG----LLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITD 1810
Score = 58.8 bits (136), Expect = 2e-07
Identities = 174/874 (19%), Positives = 326/874 (37%), Gaps = 98/874 (11%)
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN-AGLSGKEMTAKTKLEKEIDEIRSKL 1034
I ++ DL +LQ ++ ++L ++++K+ L GK +LE E +E+ + L
Sbjct: 929 ITQEKNDLALQLQAEQ--DNLADAEERCHLLIKSKVQLEGKVKELSERLEDE-EEVNADL 985
Query: 1035 SKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEM 1094
+ + +E L+ +I LK AK E +K NK K L E + L LT+E
Sbjct: 986 AARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEK 1045
Query: 1095 K-----------NREAQINKLSADLKNATSLQTTMSD--CMXXXXXXXXXXXXXXXXXXX 1141
K + +A+ +++SA K L+ + D C
Sbjct: 1046 KALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLE 1105
Query: 1142 XXXQVDNYTKID--QDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEK---QLSTRKD 1196
++ + D QDK +L +++ K ++ +++K +L R +
Sbjct: 1106 GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAE 1165
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+ + R EL+ +E EAE+ L+
Sbjct: 1166 ELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRR 1225
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALR--------QTTNDKYDEATSPVEM-------- 1300
+ E E+T+AA + KQ E A Q K ++ S + M
Sbjct: 1226 ELEEAALRHEATVAA--LRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAAN 1283
Query: 1301 VE-MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXX 1359
VE + +D+L+ AKIK+E+ + + + A + +L+++ +L
Sbjct: 1284 VETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEK 1343
Query: 1360 XXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM-----RIAHDKDVKNK--------D 1406
+ +EL L+ E K + + HD D+ +
Sbjct: 1344 ECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQ 1403
Query: 1407 AELATL--KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE--YEELTGKY 1462
AEL L K ++ + S A I + +E EE KKL +L L++AE E K
Sbjct: 1404 AELQRLLSKANAEVAQWRSKYEADAI-QRTEELEEAKKKL--ALRLQEAEEGVEAANAKC 1460
Query: 1463 ELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEM 1522
LE+ K RL E E EL + ++A + Q L ++ EM
Sbjct: 1461 SSLEK----AKLRLQTESEDVTLEL----ERATSAAAALDKKQRHLERALEERRRQEEEM 1512
Query: 1523 QNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXX 1582
Q + + Q G G E+ R R E L A + ++ +
Sbjct: 1513 QRELEAAQRESRGLGTELFRLR-----HGHEEALEALETLKRENKNLQEEISDLTDQVSL 1567
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT-RYEGQMNTMR 1641
+ + K ++ +E++E A E+ +TKT R + +++ ++
Sbjct: 1568 SGKSIQELEKTKK-------ALEGEKSEIQAALEEAEGA--LELEETKTLRIQLELSQVK 1618
Query: 1642 DEL-KSLHNQVSRFRRERDNYKQMLEAAQKSM-AEIKNGDKSARIHRNSISSTDEEEYRN 1699
E+ + L + R N+++ +E+ Q S+ AE + +++ R+ + ++
Sbjct: 1619 AEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLND----- 1673
Query: 1700 KVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEE--ERLLS 1757
LE Q+ + E++ + +L E++ + + + L+E + ER S
Sbjct: 1674 ----LELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE-QRLAAELHEQAQALERRAS 1728
Query: 1758 SGRARVAGLATRMELAWHKERDEQQRLLQETSTL 1791
A + L +E R +Q LL+ T L
Sbjct: 1729 LLAAELEELRAALEQGERSRRLAEQELLEATERL 1762
Score = 54.4 bits (125), Expect = 4e-06
Identities = 175/937 (18%), Positives = 346/937 (36%), Gaps = 81/937 (8%)
Query: 650 LRKTAARVE---EDNESLLLQLKK--MATKARSRKLSPTPPANKLSIETANDNDEKETDE 704
L K R+E ED E L Q KK M T+ RKL KL+ E+ D +
Sbjct: 1069 LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL---KLTQESVADAAQ----- 1120
Query: 705 ADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
D +++ L+ + E + L +VE+ + ++K++KEL ++ + + A
Sbjct: 1121 -DKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAER--AA 1177
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
R+ A ++ L + ++E + C + AEL +++ +
Sbjct: 1178 RARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEAT 1237
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
+ + + ++ EQ S+ R + Q LE + +L+ E L N ++L KA
Sbjct: 1238 VAALRRKQAEGAAELGEQVDSLQRVR-QKLEKEKSELRMEVD--DLAANVETLTRAKASA 1294
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK-----KETDTLKSKQXX 939
+T E++L EA K++EL+ D +++ TE+ + +E + L S+
Sbjct: 1295 EKLCRT--YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1352
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIP----KKPTDLTTKLQLKKMVED 995
++ KS A ++ + + + + +L++++
Sbjct: 1353 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 1412
Query: 996 LECEIGEMYVVMKNAGLSGKEMT--AKTKLEKEIDEIRSKLSKND---SEFTNEKNRLQT 1050
E+ + + + E AK KL + E + + S K RLQT
Sbjct: 1413 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 1472
Query: 1051 EIAKLKDVNAKLEGDKDVFA---NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
E +DV +LE A K + LE Q + + E++ + + L +
Sbjct: 1473 ES---EDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTE 1529
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEV-GDK 1166
L L+ + + QV K Q+ K K + G+K
Sbjct: 1530 LFR---LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1586
Query: 1167 TK---KIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS 1223
++ + + RI+ +LS K V + L H+R
Sbjct: 1587 SEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDE---ECANLRRNHQRAV 1643
Query: 1224 IELTSEKD-ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE-- 1280
L + D E +AR K +E ++ DL+ + AA + QL+
Sbjct: 1644 ESLQASLDAETRARNEALRLKK-KMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE 1702
Query: 1281 ----DALRQTTNDKYDEATS--------PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
D ++ + +++A + E+ E+R + EL A +L
Sbjct: 1703 QAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERL 1762
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKL--------ENXXXXXXXXXXXXXXXSSYWENKAKEL 1380
++++ + +L++DLA+L + + E KE
Sbjct: 1763 NLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ 1822
Query: 1381 DTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEET 1440
DT ER K + + + ++AE A L+G K +++ + EL E ++
Sbjct: 1823 DTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKH 1882
Query: 1441 VKKL----EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELST 1496
+ L +H +++ Y+ + L + +V K + V+ + Q E +++ +T
Sbjct: 1883 AEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE--EAEQQANT 1940
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
L + + Q +L + +T+ A ++ L
Sbjct: 1941 NLAKYRKAQHELDDAEERADMAETQANKLRARTRDAL 1977
>AL132825-6|CAI43047.2| 1983|Homo sapiens myosin, heavy chain 7B,
cardiac muscle, beta protein.
Length = 1983
Score = 81.8 bits (193), Expect = 2e-14
Identities = 178/909 (19%), Positives = 365/909 (40%), Gaps = 67/909 (7%)
Query: 190 ERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKN----SRNSTNLKPPVRGGPXXX 245
E++ L S E EK R ER+ K + + + ++ +++ L+ ++
Sbjct: 1077 EQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 1136
Query: 246 XXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDIL--LRRLA 303
+ +KE Q + E L++E++ R RVEK++++ L L+
Sbjct: 1137 SQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELS 1196
Query: 304 -NIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEA 362
++ A + G+ K + ++ L E+ + +R + E
Sbjct: 1197 ERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALR--RKQAEGAAELGE 1254
Query: 363 QTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSL 420
Q ++++R KL E EL E +D+ + L + R EDQ E
Sbjct: 1255 QVDSLQRVRQKL---EKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIK 1311
Query: 421 RRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKEL 478
EL++ + + +L+ + +L +EK E + ++ G E ++L
Sbjct: 1312 VEELQRQLADASTQRGRLQTESGELSRLLEEK---ECLISQLSRGKALAAQSLEELRRQL 1368
Query: 479 EQEVARSTEVALRLQR------ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ 532
E+E + +A +Q L E + + + L ++ +V++ R +
Sbjct: 1369 EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQ---WRSKYE 1425
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
D Q +L+++ ++ A LR Q E AN K + L+K + + T ES
Sbjct: 1426 ADAIQRTEELEEAKKKLA-LRLQEAEEGVEAANAK----CSSLEKAKL--RLQT----ES 1474
Query: 593 ETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRK 652
E VT ++ + AA+ K++ L ++ +E + +L + L +
Sbjct: 1475 EDVTLELE-RATSAAAALDKKQRHLERALE-ERRRQEEEMQRELEAAQRESRGLGTELFR 1532
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE-KETDEADPAEMK 711
EE E+ L+ K K ++S LS ++ + ++ K+ E + +E++
Sbjct: 1533 LRHGHEEALEA--LETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ 1590
Query: 712 LLLE-----LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS 766
LE L +E LR ++ EL Q K + +++ E + +++ + + + + S
Sbjct: 1591 AALEEAEGALELEETKTLRIQL-ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQAS 1649
Query: 767 L--TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
L T + A K +E +++++ +L R A L Q + K + D
Sbjct: 1650 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKE--EQAGRD 1707
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA-----DNEKLQTENKKLQLLKNAKSLRS 879
+ +L Q Q +E+ AS+L A+ + L A + + E + L+ + L S
Sbjct: 1708 EEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHS 1767
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXX 939
LN KK +LE +L + +++E ++ + + K T+A + LK +Q
Sbjct: 1768 QNTGLLNQKK--KLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMM-AEELKKEQDT 1824
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPK---KPTDLTTKL--QLKKMVE 994
QA L+ + A + K ++ K K +L +L + KK E
Sbjct: 1825 SAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 1884
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
L+ V + A + ++ +++ +D+++SK+ +F + + T +AK
Sbjct: 1885 ALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAK 1944
Query: 1055 LKDVNAKLE 1063
+ +L+
Sbjct: 1945 YRKAQHELD 1953
Score = 78.2 bits (184), Expect = 3e-13
Identities = 186/835 (22%), Positives = 351/835 (42%), Gaps = 96/835 (11%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
K++ + + A ++ LR L AAE +EL + + + +E DL
Sbjct: 884 KMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAE 943
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER-KAD------QLEQEKAEHEK- 457
QDN D + L + Q + LS +L+ E AD +LE E E +K
Sbjct: 944 QDNL-ADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKD 1002
Query: 458 ----KLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE---LAEANSKFTGSNPSL 510
KL + EN++K L +E+A E RL +E L EA+ + G
Sbjct: 1003 IDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGD---- 1058
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
Q E +V S+LT+ + + Q + DL+ SLE+E LR A+ + ++
Sbjct: 1059 ---LQAEEDRV--SALTKAKLRLE--QQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLT 1111
Query: 571 PPTFL----DKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKT 626
+ DKQ + + + D E ++ ++++ + A ++ + +++
Sbjct: 1112 QESVADAAQDKQQLEEKLKKKD-SELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEE 1170
Query: 627 TEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPA 686
E + + AA L + + R+EE + Q + + R +L
Sbjct: 1171 LEAER--AARARVEKQRAEAARELEELSERLEEAGGASAGQ--REGCRKREAELGRL--- 1223
Query: 687 NKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELT 746
+ +E A E + + EL EQ L+R ++LE++K L+ +V +L
Sbjct: 1224 -RRELEEAALRHEATVAALRRKQAEGAAELGEQ-VDSLQRVRQKLEKEKSELRMEVDDLA 1281
Query: 747 SKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLH-- 804
+ + ++T+ A + R T ++L+E ++KV +E++++L + RL
Sbjct: 1282 ANVETLTRAKASAEKLCR----TYEDQLSEAKIKV-----EELQRQLADASTQRGRLQTE 1332
Query: 805 -AELSLAQKKPKTLIK--SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
ELS ++ + LI SR + Q +L+RQL+ + S L Q+L D + L
Sbjct: 1333 SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLL 1392
Query: 862 ----------QTENKKLQLLKNAK--SLRSDKALDLNTKKTTQLENELKEALAKIKELE- 908
Q E ++L NA+ RS D ++T +LE K+ +++E E
Sbjct: 1393 REQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADA-IQRTEELEEAKKKLALRLQEAEE 1451
Query: 909 -MICQDEK--SEKKVRFTEATKKETDTLKSKQXXXXXXX-----XXXXXXXXXXXXXQAT 960
+ + K S +K + T+ E TL+ ++ +
Sbjct: 1452 GVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEE 1511
Query: 961 LKSLKDDAQKSFKP------RIPKKPTDLTTKLQ-LKKMVEDLECEIGEMYVVMKNAGLS 1013
++ + AQ+ + R+ + L+ LK+ ++L+ EI ++ + +G S
Sbjct: 1512 MQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKS 1571
Query: 1014 GKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEKN---RLQTEIAKLK-DVNAKL-EGDKD 1067
+E+ K LE E EI++ L + + E+ R+Q E++++K +V+ KL E D++
Sbjct: 1572 IQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEE 1631
Query: 1068 ---VFANKYKALENENSNLSNQCKTLTEEM---KNREAQINKLSADLKNATSLQT 1116
+ N +A+E+ ++L + + E + K E +N L L +AT T
Sbjct: 1632 CANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAT 1686
Score = 72.9 bits (171), Expect = 1e-11
Identities = 171/899 (19%), Positives = 347/899 (38%), Gaps = 86/899 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKT-- 755
DE + D ++KL L E+E KV+ L ++ AL + V LT + ++ +
Sbjct: 994 DECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 1053
Query: 756 SAGSNTTA---RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQK 812
A + A R S T + E++V+ LE +++ +K ++ ER +L +L L Q+
Sbjct: 1054 QALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 1113
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
S+ + Q L+ +L+ + E S L + + + ++Q + K+LQ
Sbjct: 1114 ---------SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ--- 1161
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD- 931
A++ ++ L+ ++E + EA +++EL ++ + K+E +
Sbjct: 1162 -ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAEL 1220
Query: 932 -TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
L+ + A + D+ + + ++ K+ K +L+
Sbjct: 1221 GRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKE------KSELR 1274
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSK---LSKNDSEFTNEKNR 1047
V+DL + + +A E +T E ++ E + K L + ++ + ++ R
Sbjct: 1275 MEVDDLAANVETLTRAKASA-----EKLCRT-YEDQLSEAKIKVEELQRQLADASTQRGR 1328
Query: 1048 LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
LQTE +L + LE + + + + +L + L EE K + A + + A
Sbjct: 1329 LQTESGELSRL---LEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA- 1384
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKLLKEVGDK 1166
L++ L + +V + +K + D + +E+ +
Sbjct: 1385 LRHDCDLLREQHE------EEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEA 1438
Query: 1167 TKKIG----DXXXXXXXXXXXCKRIEK---QLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
KK+ + C +EK +L T + VT
Sbjct: 1439 KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHL 1498
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R E +++E+Q + + L E+ L+ +E + +LE+ +K+
Sbjct: 1499 ERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALET--------LKRE 1550
Query: 1280 EDALRQTTNDKYDEAT-SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAA 1338
L++ +D D+ + S + E+ Q L A+ LE E ++
Sbjct: 1551 NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRI 1610
Query: 1339 KLEMAQLKSDL-----------AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
+LE++Q+K+++ A L + N+A L ++ +
Sbjct: 1611 QLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGD 1670
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
L+ +++ H + +A+ AT + ++ E+ +G ++ L E E + LE
Sbjct: 1671 LNDLE-LQLGH-ATRQATEAQAATRLMQAQLKEEQAGRDEEQ--RLAAELHEQAQALERR 1726
Query: 1448 LALEKAEYEELTGKYE-------LLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE 1500
+L AE EEL E L E+E + RL + Q G LL+ +K+L L +
Sbjct: 1727 ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG-LLNQKKKLEADLAQ 1785
Query: 1501 IK-TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
+ ++E A K + ++ +E R+ L+Q REL+A
Sbjct: 1786 LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQA 1844
Score = 71.7 bits (168), Expect = 2e-11
Identities = 175/886 (19%), Positives = 356/886 (40%), Gaps = 110/886 (12%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTGRSSEVL 320
++ +D+ LK+++D L+ + EKEK L +A +D + T +
Sbjct: 990 RKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1049
Query: 321 KL-QQKVNELTTHNE---DLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIE-QLR 371
+ QQ + +L + L K L Q++ ++E LE R TE R++E L+
Sbjct: 1050 EAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLK 1109
Query: 372 AKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDN-----FREDQADEYSSLRRELEQ 426
+ ++ E +KK+ +L ++D + + E + ELE+
Sbjct: 1110 LTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEE 1169
Query: 427 TIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST 486
++ R +++K +A + +E +E LE GG QRE ++ E E+
Sbjct: 1170 ELEAERAARARVEKQRAEAARELEELSER----LEEAGGASAGQREG-CRKREAELG--- 1221
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL 546
RL+REL EA + + +L + ++ G Q D Q +R L
Sbjct: 1222 ----RLRRELEEAALRHEATVAALRRKQAEGAAEL--------GEQVDSLQRVR---QKL 1266
Query: 547 EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ----NK 602
E+E + +LR ++ A N T + + + C +E + I+ +
Sbjct: 1267 EKE---KSELRMEVDDLA----ANVETLTRAKASAEKL--CRTYEDQLSEAKIKVEELQR 1317
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ AST + +++S LS + EE + + LS +AA +L + ++EE+++
Sbjct: 1318 QLADASTQRGRLQTESGELS--RLLEEKECL--ISQLSRGKALAAQSLEELRRQLEEESK 1373
Query: 663 S----------------LLLQLKKMATKARS--RKLSPTPPANKLSIETANDNDE-KETD 703
+ LL + + +A++ ++L A + + D + T+
Sbjct: 1374 AKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTE 1433
Query: 704 EADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
E + A+ KL L L E E V K LE+ K L+ + +++T ++ T +A +
Sbjct: 1434 ELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDK 1493
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
R + + EER + + +E++++L +R+ L EL + + ++
Sbjct: 1494 KQR-----HLERALEERRR----QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE-- 1542
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
+L+ ++N +L+ ++ + + S+ Q LE + L+ E ++Q A ++
Sbjct: 1543 ALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ----AALEEAEG 1598
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
AL+L KT +++ EL + A++ + +EK + ++S Q
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDR-------KLAEKDEECANLRRNHQRAVESLQASLD 1651
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ L L + Q R + T +Q + E +
Sbjct: 1652 AETRARNEALRLKKKMEGDLNDL--ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE 1709
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
+ + E A + L E++E+R+ L + + + L +L ++++
Sbjct: 1710 QRLAAELHEQAQALERRA-SLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1768
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
G N+ K LE + + LS + + +E + E + K D
Sbjct: 1769 NTG----LLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITD 1810
Score = 58.8 bits (136), Expect = 2e-07
Identities = 174/874 (19%), Positives = 326/874 (37%), Gaps = 98/874 (11%)
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN-AGLSGKEMTAKTKLEKEIDEIRSKL 1034
I ++ DL +LQ ++ ++L ++++K+ L GK +LE E +E+ + L
Sbjct: 929 ITQEKNDLALQLQAEQ--DNLADAEERCHLLIKSKVQLEGKVKELSERLEDE-EEVNADL 985
Query: 1035 SKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEM 1094
+ + +E L+ +I LK AK E +K NK K L E + L LT+E
Sbjct: 986 AARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEK 1045
Query: 1095 K-----------NREAQINKLSADLKNATSLQTTMSD--CMXXXXXXXXXXXXXXXXXXX 1141
K + +A+ +++SA K L+ + D C
Sbjct: 1046 KALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLE 1105
Query: 1142 XXXQVDNYTKID--QDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEK---QLSTRKD 1196
++ + D QDK +L +++ K ++ +++K +L R +
Sbjct: 1106 GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAE 1165
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
+ + R EL+ +E EAE+ L+
Sbjct: 1166 ELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRR 1225
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALR--------QTTNDKYDEATSPVEM-------- 1300
+ E E+T+AA + KQ E A Q K ++ S + M
Sbjct: 1226 ELEEAALRHEATVAA--LRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAAN 1283
Query: 1301 VE-MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXX 1359
VE + +D+L+ AKIK+E+ + + + A + +L+++ +L
Sbjct: 1284 VETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEK 1343
Query: 1360 XXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM-----RIAHDKDVKNK--------D 1406
+ +EL L+ E K + + HD D+ +
Sbjct: 1344 ECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQ 1403
Query: 1407 AELATL--KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE--YEELTGKY 1462
AEL L K ++ + S A I + +E EE KKL +L L++AE E K
Sbjct: 1404 AELQRLLSKANAEVAQWRSKYEADAI-QRTEELEEAKKKL--ALRLQEAEEGVEAANAKC 1460
Query: 1463 ELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEM 1522
LE+ K RL E E EL + ++A + Q L ++ EM
Sbjct: 1461 SSLEK----AKLRLQTESEDVTLEL----ERATSAAAALDKKQRHLERALEERRRQEEEM 1512
Query: 1523 QNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXX 1582
Q + + Q G G E+ R R E L A + ++ +
Sbjct: 1513 QRELEAAQRESRGLGTELFRLR-----HGHEEALEALETLKRENKNLQEEISDLTDQVSL 1567
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT-RYEGQMNTMR 1641
+ + K ++ +E++E A E+ +TKT R + +++ ++
Sbjct: 1568 SGKSIQELEKTKK-------ALEGEKSEIQAALEEAEGA--LELEETKTLRIQLELSQVK 1618
Query: 1642 DEL-KSLHNQVSRFRRERDNYKQMLEAAQKSM-AEIKNGDKSARIHRNSISSTDEEEYRN 1699
E+ + L + R N+++ +E+ Q S+ AE + +++ R+ + ++
Sbjct: 1619 AEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLND----- 1673
Query: 1700 KVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEE--ERLLS 1757
LE Q+ + E++ + +L E++ + + + L+E + ER S
Sbjct: 1674 ----LELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE-QRLAAELHEQAQALERRAS 1728
Query: 1758 SGRARVAGLATRMELAWHKERDEQQRLLQETSTL 1791
A + L +E R +Q LL+ T L
Sbjct: 1729 LLAAELEELRAALEQGERSRRLAEQELLEATERL 1762
Score = 54.4 bits (125), Expect = 4e-06
Identities = 175/937 (18%), Positives = 346/937 (36%), Gaps = 81/937 (8%)
Query: 650 LRKTAARVE---EDNESLLLQLKK--MATKARSRKLSPTPPANKLSIETANDNDEKETDE 704
L K R+E ED E L Q KK M T+ RKL KL+ E+ D +
Sbjct: 1069 LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL---KLTQESVADAAQ----- 1120
Query: 705 ADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
D +++ L+ + E + L +VE+ + ++K++KEL ++ + + A
Sbjct: 1121 -DKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAER--AA 1177
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
R+ A ++ L + ++E + C + AEL +++ +
Sbjct: 1178 RARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEAT 1237
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
+ + + ++ EQ S+ R + Q LE + +L+ E L N ++L KA
Sbjct: 1238 VAALRRKQAEGAAELGEQVDSLQRVR-QKLEKEKSELRMEVD--DLAANVETLTRAKASA 1294
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK-----KETDTLKSKQXX 939
+T E++L EA K++EL+ D +++ TE+ + +E + L S+
Sbjct: 1295 EKLCRT--YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1352
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIP----KKPTDLTTKLQLKKMVED 995
++ KS A ++ + + + + +L++++
Sbjct: 1353 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 1412
Query: 996 LECEIGEMYVVMKNAGLSGKEMT--AKTKLEKEIDEIRSKLSKND---SEFTNEKNRLQT 1050
E+ + + + E AK KL + E + + S K RLQT
Sbjct: 1413 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 1472
Query: 1051 EIAKLKDVNAKLEGDKDVFA---NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
E +DV +LE A K + LE Q + + E++ + + L +
Sbjct: 1473 ES---EDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTE 1529
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEV-GDK 1166
L L+ + + QV K Q+ K K + G+K
Sbjct: 1530 LFR---LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1586
Query: 1167 TK---KIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS 1223
++ + + RI+ +LS K V + L H+R
Sbjct: 1587 SEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDE---ECANLRRNHQRAV 1643
Query: 1224 IELTSEKD-ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE-- 1280
L + D E +AR K +E ++ DL+ + AA + QL+
Sbjct: 1644 ESLQASLDAETRARNEALRLKK-KMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE 1702
Query: 1281 ----DALRQTTNDKYDEATS--------PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
D ++ + +++A + E+ E+R + EL A +L
Sbjct: 1703 QAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERL 1762
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKL--------ENXXXXXXXXXXXXXXXSSYWENKAKEL 1380
++++ + +L++DLA+L + + E KE
Sbjct: 1763 NLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ 1822
Query: 1381 DTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEET 1440
DT ER K + + + ++AE A L+G K +++ + EL E ++
Sbjct: 1823 DTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKH 1882
Query: 1441 VKKL----EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELST 1496
+ L +H +++ Y+ + L + +V K + V+ + Q E +++ +T
Sbjct: 1883 AEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE--EAEQQANT 1940
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
L + + Q +L + +T+ A ++ L
Sbjct: 1941 NLAKYRKAQHELDDAEERADMAETQANKLRARTRDAL 1977
>AB040945-1|BAA96036.2| 2010|Homo sapiens KIAA1512 protein protein.
Length = 2010
Score = 81.8 bits (193), Expect = 2e-14
Identities = 178/909 (19%), Positives = 365/909 (40%), Gaps = 67/909 (7%)
Query: 190 ERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKN----SRNSTNLKPPVRGGPXXX 245
E++ L S E EK R ER+ K + + + ++ +++ L+ ++
Sbjct: 1104 EQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 1163
Query: 246 XXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDIL--LRRLA 303
+ +KE Q + E L++E++ R RVEK++++ L L+
Sbjct: 1164 SQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELS 1223
Query: 304 -NIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEA 362
++ A + G+ K + ++ L E+ + +R + E
Sbjct: 1224 ERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALR--RKQAEGAAELGE 1281
Query: 363 QTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSL 420
Q ++++R KL E EL E +D+ + L + R EDQ E
Sbjct: 1282 QVDSLQRVRQKL---EKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIK 1338
Query: 421 RRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGP--DGMQRENRIKEL 478
EL++ + + +L+ + +L +EK E + ++ G E ++L
Sbjct: 1339 VEELQRQLADASTQRGRLQTESGELSRLLEEK---ECLISQLSRGKALAAQSLEELRRQL 1395
Query: 479 EQEVARSTEVALRLQR------ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ 532
E+E + +A +Q L E + + + L ++ +V++ R +
Sbjct: 1396 EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQ---WRSKYE 1452
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
D Q +L+++ ++ A LR Q E AN K + L+K + + T ES
Sbjct: 1453 ADAIQRTEELEEAKKKLA-LRLQEAEEGVEAANAK----CSSLEKAKL--RLQT----ES 1501
Query: 593 ETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRK 652
E VT ++ + AA+ K++ L ++ +E + +L + L +
Sbjct: 1502 EDVTLELE-RATSAAAALDKKQRHLERALE-ERRRQEEEMQRELEAAQRESRGLGTELFR 1559
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDE-KETDEADPAEMK 711
EE E+ L+ K K ++S LS ++ + ++ K+ E + +E++
Sbjct: 1560 LRHGHEEALEA--LETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ 1617
Query: 712 LLLE-----LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS 766
LE L +E LR ++ EL Q K + +++ E + +++ + + + + S
Sbjct: 1618 AALEEAEGALELEETKTLRIQL-ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQAS 1676
Query: 767 L--TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
L T + A K +E +++++ +L R A L Q + K + D
Sbjct: 1677 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKE--EQAGRD 1734
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA-----DNEKLQTENKKLQLLKNAKSLRS 879
+ +L Q Q +E+ AS+L A+ + L A + + E + L+ + L S
Sbjct: 1735 EEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHS 1794
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXX 939
LN KK +LE +L + +++E ++ + + K T+A + LK +Q
Sbjct: 1795 QNTGLLNQKK--KLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMM-AEELKKEQDT 1851
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPK---KPTDLTTKL--QLKKMVE 994
QA L+ + A + K ++ K K +L +L + KK E
Sbjct: 1852 SAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 1911
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
L+ V + A + ++ +++ +D+++SK+ +F + + T +AK
Sbjct: 1912 ALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAK 1971
Query: 1055 LKDVNAKLE 1063
+ +L+
Sbjct: 1972 YRKAQHELD 1980
Score = 78.6 bits (185), Expect = 2e-13
Identities = 186/835 (22%), Positives = 353/835 (42%), Gaps = 96/835 (11%)
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
K++ + + A ++ LR L AAE +EL + + + +E DL
Sbjct: 911 KMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAE 970
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER-KAD------QLEQEKAEHEKK 458
QDN D + L + Q + LS +L+ E AD +LE E E +K
Sbjct: 971 QDNL-ADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKD 1029
Query: 459 L--LEIV---GGPDGMQRENRIKELEQEVARSTEVALRLQRE---LAEANSKFTGSNPSL 510
+ LE+ + EN++K L +E+A E RL +E L EA+ + G
Sbjct: 1030 IDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGD---- 1085
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
Q E +V S+LT+ + + Q + DL+ SLE+E LR A+ + ++
Sbjct: 1086 ---LQAEEDRV--SALTKAKLRLE--QQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLT 1138
Query: 571 PPTFL----DKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKT 626
+ DKQ + + + D E ++ ++++ + A ++ + +++
Sbjct: 1139 QESVADAAQDKQQLEEKLKKKD-SELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEE 1197
Query: 627 TEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPA 686
E + + AA L + + R+EE + Q + + R +L
Sbjct: 1198 LEAER--AARARVEKQRAEAARELEELSERLEEAGGASAGQ--REGCRKREAELGRL--- 1250
Query: 687 NKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELT 746
+ +E A E + + EL EQ L+R ++LE++K L+ +V +L
Sbjct: 1251 -RRELEEAALRHEATVAALRRKQAEGAAELGEQ-VDSLQRVRQKLEKEKSELRMEVDDLA 1308
Query: 747 SKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLH-- 804
+ + ++T+ A + R T ++L+E ++KV +E++++L + RL
Sbjct: 1309 ANVETLTRAKASAEKLCR----TYEDQLSEAKIKV-----EELQRQLADASTQRGRLQTE 1359
Query: 805 -AELSLAQKKPKTLIK--SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
ELS ++ + LI SR + Q +L+RQL+ + S L Q+L D + L
Sbjct: 1360 SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLL 1419
Query: 862 ----------QTENKKLQLLKNAK--SLRSDKALDLNTKKTTQLENELKEALAKIKELE- 908
Q E ++L NA+ RS D ++T +LE K+ +++E E
Sbjct: 1420 REQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADA-IQRTEELEEAKKKLALRLQEAEE 1478
Query: 909 -MICQDEK--SEKKVRFTEATKKETDTLKSKQXXXXXXX-----XXXXXXXXXXXXXQAT 960
+ + K S +K + T+ E TL+ ++ +
Sbjct: 1479 GVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEE 1538
Query: 961 LKSLKDDAQKSFKP------RIPKKPTDLTTKLQ-LKKMVEDLECEIGEMYVVMKNAGLS 1013
++ + AQ+ + R+ + L+ LK+ ++L+ EI ++ + +G S
Sbjct: 1539 MQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKS 1598
Query: 1014 GKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEKN---RLQTEIAKLK-DVNAKL-EGDKD 1067
+E+ K LE E EI++ L + + E+ R+Q E++++K +V+ KL E D++
Sbjct: 1599 IQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEE 1658
Query: 1068 ---VFANKYKALENENSNLSNQCKTLTEEM---KNREAQINKLSADLKNATSLQT 1116
+ N +A+E+ ++L + + E + K E +N L L +AT T
Sbjct: 1659 CANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAT 1713
Score = 71.3 bits (167), Expect = 3e-11
Identities = 170/899 (18%), Positives = 347/899 (38%), Gaps = 86/899 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKT-- 755
DE + D +++L L E+E KV+ L ++ AL + V LT + ++ +
Sbjct: 1021 DECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 1080
Query: 756 SAGSNTTA---RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQK 812
A + A R S T + E++V+ LE +++ +K ++ ER +L +L L Q+
Sbjct: 1081 QALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 1140
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
S+ + Q L+ +L+ + E S L + + + ++Q + K+LQ
Sbjct: 1141 ---------SVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ--- 1188
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD- 931
A++ ++ L+ ++E + EA +++EL ++ + K+E +
Sbjct: 1189 -ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAEL 1247
Query: 932 -TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
L+ + A + D+ + + ++ K+ K +L+
Sbjct: 1248 GRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKE------KSELR 1301
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSK---LSKNDSEFTNEKNR 1047
V+DL + + +A E +T E ++ E + K L + ++ + ++ R
Sbjct: 1302 MEVDDLAANVETLTRAKASA-----EKLCRT-YEDQLSEAKIKVEELQRQLADASTQRGR 1355
Query: 1048 LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
LQTE +L + LE + + + + +L + L EE K + A + + A
Sbjct: 1356 LQTESGELSRL---LEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA- 1411
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKLLKEVGDK 1166
L++ L + +V + +K + D + +E+ +
Sbjct: 1412 LRHDCDLLREQHE------EEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEA 1465
Query: 1167 TKKIG----DXXXXXXXXXXXCKRIEK---QLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
KK+ + C +EK +L T + VT
Sbjct: 1466 KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHL 1525
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
R E +++E+Q + + L E+ L+ +E + +LE+ +K+
Sbjct: 1526 ERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALET--------LKRE 1577
Query: 1280 EDALRQTTNDKYDEAT-SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAA 1338
L++ +D D+ + S + E+ Q L A+ LE E ++
Sbjct: 1578 NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRI 1637
Query: 1339 KLEMAQLKSDL-----------AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE 1387
+LE++Q+K+++ A L + N+A L ++ +
Sbjct: 1638 QLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGD 1697
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
L+ +++ H + +A+ AT + ++ E+ +G ++ L E E + LE
Sbjct: 1698 LNDLE-LQLGH-ATRQATEAQAATRLMQAQLKEEQAGRDEEQ--RLAAELHEQAQALERR 1753
Query: 1448 LALEKAEYEELTGKYE-------LLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE 1500
+L AE EEL E L E+E + RL + Q G LL+ +K+L L +
Sbjct: 1754 ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG-LLNQKKKLEADLAQ 1812
Query: 1501 IK-TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
+ ++E A K + ++ +E R+ L+Q REL+A
Sbjct: 1813 LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQA 1871
Score = 70.9 bits (166), Expect = 4e-11
Identities = 175/886 (19%), Positives = 355/886 (40%), Gaps = 110/886 (12%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTGRSSEVL 320
++ +D+ LK+++D L + EKEK L +A +D + T +
Sbjct: 1017 RKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1076
Query: 321 KL-QQKVNELTTHNE---DLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIE-QLR 371
+ QQ + +L + L K L Q++ ++E LE R TE R++E L+
Sbjct: 1077 EAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLK 1136
Query: 372 AKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDN-----FREDQADEYSSLRRELEQ 426
+ ++ E +KK+ +L ++D + + E + ELE+
Sbjct: 1137 LTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEE 1196
Query: 427 TIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARST 486
++ R +++K +A + +E +E LE GG QRE ++ E E+
Sbjct: 1197 ELEAERAARARVEKQRAEAARELEELSER----LEEAGGASAGQREG-CRKREAELG--- 1248
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL 546
RL+REL EA + + +L + ++ G Q D Q +R L
Sbjct: 1249 ----RLRRELEEAALRHEATVAALRRKQAEGAAEL--------GEQVDSLQRVR---QKL 1293
Query: 547 EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ----NK 602
E+E + +LR ++ A N T + + + C +E + I+ +
Sbjct: 1294 EKE---KSELRMEVDDLA----ANVETLTRAKASAEKL--CRTYEDQLSEAKIKVEELQR 1344
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE 662
+ AST + +++S LS + EE + + LS +AA +L + ++EE+++
Sbjct: 1345 QLADASTQRGRLQTESGELS--RLLEEKECL--ISQLSRGKALAAQSLEELRRQLEEESK 1400
Query: 663 S----------------LLLQLKKMATKARS--RKLSPTPPANKLSIETANDNDE-KETD 703
+ LL + + +A++ ++L A + + D + T+
Sbjct: 1401 AKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTE 1460
Query: 704 EADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
E + A+ KL L L E E V K LE+ K L+ + +++T ++ T +A +
Sbjct: 1461 ELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDK 1520
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
R + + EER + + +E++++L +R+ L EL + + ++
Sbjct: 1521 KQR-----HLERALEERRR----QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE-- 1569
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
+L+ ++N +L+ ++ + + S+ Q LE + L+ E ++Q A ++
Sbjct: 1570 ALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ----AALEEAEG 1625
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
AL+L KT +++ EL + A++ + +EK + ++S Q
Sbjct: 1626 ALELEETKTLRIQLELSQVKAEVDR-------KLAEKDEECANLRRNHQRAVESLQASLD 1678
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ L L + Q R + T +Q + E +
Sbjct: 1679 AETRARNEALRLKKKMEGDLNDL--ELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE 1736
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
+ + E A + L E++E+R+ L + + + L +L ++++
Sbjct: 1737 QRLAAELHEQAQALERRA-SLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1795
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
G N+ K LE + + LS + + +E + E + K D
Sbjct: 1796 NTG----LLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITD 1837
Score = 57.2 bits (132), Expect = 6e-07
Identities = 156/847 (18%), Positives = 314/847 (37%), Gaps = 80/847 (9%)
Query: 983 LTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK---TKLEKEIDEIRSKLSKNDS 1039
+ +K+QL+ V++L + + V NA L+ + + T+L+K+ID++ L+K +
Sbjct: 985 IKSKVQLEGKVKELSERLEDEEEV--NADLAARRRKLEDECTELKKDIDDLELTLAKAEK 1042
Query: 1040 EFTNEKNRLQT---EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKN 1096
E +N+++ E+A L + A+L +K ++ + ++ LT+
Sbjct: 1043 EKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLR 1102
Query: 1097 REAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN-YTKIDQD 1155
E Q+ L L+ L+ Q++ K D +
Sbjct: 1103 LEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSE 1162
Query: 1156 KNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVL 1215
++L V D+ + +E++L + + L
Sbjct: 1163 LSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEEL 1222
Query: 1216 ANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVH 1275
+ +++ + R E++ L E+ + +E + +L A
Sbjct: 1223 SERLEEAGGASAGQREGCRKR----EAELGRLRRELEEAALRHEATVAALRRKQAEGAAE 1278
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEM--------VE-MRXXXXXXXXXXXXXQDELNNAKI 1326
+ + D+L Q K ++ S + M VE + +D+L+ AKI
Sbjct: 1279 LGEQVDSL-QRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKI 1337
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQS 1386
K+E+ + + + A + +L+++ +L + +EL L+
Sbjct: 1338 KVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEE 1397
Query: 1387 ERKKLDRM-----RIAHDKDVKNK--------DAELATL--KGKLKILEQNSGAGAKRIT 1431
E K + + HD D+ + AEL L K ++ + S A I
Sbjct: 1398 ESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAI- 1456
Query: 1432 ELKQEYEETVKKLEHSLALEKAE--YEELTGKYELLEEEHVVTKARLTVEKEQAQGELLH 1489
+ +E EE KKL +L L++AE E K LE+ K RL E E EL
Sbjct: 1457 QRTEELEEAKKKL--ALRLQEAEEGVEAANAKCSSLEK----AKLRLQTESEDVTLEL-- 1508
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARL 1549
+ ++A + Q L ++ EMQ + + Q G G E+ R R
Sbjct: 1509 --ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLR----- 1561
Query: 1550 DQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXX 1609
E L A + ++ + + + K ++
Sbjct: 1562 HGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKK-------ALEGEKS 1614
Query: 1610 XXXXXIEQSEKARKAEITDTKT-RYEGQMNTMRDEL-KSLHNQVSRFRRERDNYKQMLEA 1667
+E++E A E+ +TKT R + +++ ++ E+ + L + R N+++ +E+
Sbjct: 1615 EIQAALEEAEGA--LELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVES 1672
Query: 1668 AQKSM-AEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLN 1726
Q S+ AE + +++ R+ + ++ LE Q+ + E++ +
Sbjct: 1673 LQASLDAETRARNEALRLKKKMEGDLND---------LELQLGHATRQATEAQAATRLMQ 1723
Query: 1727 TELVSEKSSAEVRLAEMQSRLNEYEE--ERLLSSGRARVAGLATRMELAWHKERDEQQRL 1784
+L E++ + + + L+E + ER S A + L +E R +Q L
Sbjct: 1724 AQLKEEQAGRDEE-QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQEL 1782
Query: 1785 LQETSTL 1791
L+ T L
Sbjct: 1783 LEATERL 1789
Score = 54.4 bits (125), Expect = 4e-06
Identities = 175/937 (18%), Positives = 346/937 (36%), Gaps = 81/937 (8%)
Query: 650 LRKTAARVE---EDNESLLLQLKK--MATKARSRKLSPTPPANKLSIETANDNDEKETDE 704
L K R+E ED E L Q KK M T+ RKL KL+ E+ D +
Sbjct: 1096 LTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL---KLTQESVADAAQ----- 1147
Query: 705 ADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
D +++ L+ + E + L +VE+ + ++K++KEL ++ + + A
Sbjct: 1148 -DKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAER--AA 1204
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
R+ A ++ L + ++E + C + AEL +++ +
Sbjct: 1205 RARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEAT 1264
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
+ + + ++ EQ S+ R + Q LE + +L+ E L N ++L KA
Sbjct: 1265 VAALRRKQAEGAAELGEQVDSLQRVR-QKLEKEKSELRMEVD--DLAANVETLTRAKASA 1321
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK-----KETDTLKSKQXX 939
+T E++L EA K++EL+ D +++ TE+ + +E + L S+
Sbjct: 1322 EKLCRT--YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1379
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIP----KKPTDLTTKLQLKKMVED 995
++ KS A ++ + + + + +L++++
Sbjct: 1380 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 1439
Query: 996 LECEIGEMYVVMKNAGLSGKEMT--AKTKLEKEIDEIRSKLSKND---SEFTNEKNRLQT 1050
E+ + + + E AK KL + E + + S K RLQT
Sbjct: 1440 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT 1499
Query: 1051 EIAKLKDVNAKLEGDKDVFA---NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
E +DV +LE A K + LE Q + + E++ + + L +
Sbjct: 1500 ES---EDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTE 1556
Query: 1108 LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEV-GDK 1166
L L+ + + QV K Q+ K K + G+K
Sbjct: 1557 LFR---LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEK 1613
Query: 1167 TK---KIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS 1223
++ + + RI+ +LS K V + L H+R
Sbjct: 1614 SEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDE---ECANLRRNHQRAV 1670
Query: 1224 IELTSEKD-ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE-- 1280
L + D E +AR K +E ++ DL+ + AA + QL+
Sbjct: 1671 ESLQASLDAETRARNEALRLKK-KMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE 1729
Query: 1281 ----DALRQTTNDKYDEATS--------PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL 1328
D ++ + +++A + E+ E+R + EL A +L
Sbjct: 1730 QAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERL 1789
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKL--------ENXXXXXXXXXXXXXXXSSYWENKAKEL 1380
++++ + +L++DLA+L + + E KE
Sbjct: 1790 NLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ 1849
Query: 1381 DTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEET 1440
DT ER K + + + ++AE A L+G K +++ + EL E ++
Sbjct: 1850 DTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKH 1909
Query: 1441 VKKL----EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELST 1496
+ L +H +++ Y+ + L + +V K + V+ + Q E +++ +T
Sbjct: 1910 AEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE--EAEQQANT 1967
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
L + + Q +L + +T+ A ++ L
Sbjct: 1968 NLAKYRKAQHELDDAEERADMAETQANKLRARTRDAL 2004
Score = 52.0 bits (119), Expect = 2e-05
Identities = 105/537 (19%), Positives = 197/537 (36%), Gaps = 46/537 (8%)
Query: 1248 EAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEA----TSPVEMVEM 1303
E E+ L+A+ + L +AA + ++LE+ T +K D A + +
Sbjct: 922 EEELAALRAE----LRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADA 977
Query: 1304 RXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXX 1363
+ ++ +LE E ++ +L+ + +L+
Sbjct: 978 EERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTL 1037
Query: 1364 XXXXXXSSYWENKAKELDTDLQSERKKLDRM-------RIAHDKDVKNKDAE----LATL 1412
ENK K L ++ + + + R+ + AH + + + AE A
Sbjct: 1038 AKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALT 1097
Query: 1413 KGKLKILEQ--NSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE--- 1467
K KL++ +Q + ++ +L+ + E +KLE L L + + + LEE
Sbjct: 1098 KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLK 1157
Query: 1468 --EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW---NTEKTEM 1522
+ +++ L VE EQ G +QK++ + L+E+L E AA ++ E
Sbjct: 1158 KKDSELSQLSLRVEDEQLLGA--QMQKKIKELQARAEELEEELEAERAARARVEKQRAEA 1215
Query: 1523 QNSIASLQERLCGGGWEVERARLNARLDQREREL-RAANDRRDVLEHHHDXXXXXXXXXX 1581
+ L ERL G R R +RE EL R + + H
Sbjct: 1216 ARELEELSERLEEAGGASAGQREGCR--KREAELGRLRRELEEAALRHEATVAALRRKQA 1273
Query: 1582 XXXXDY-ERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT--RYEGQMN 1638
+ E+V +QR E +A+ + K YE Q++
Sbjct: 1274 EGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLS 1333
Query: 1639 TMRDELKSLHNQVS-------RFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISS 1691
+ +++ L Q++ R + E ++LE + ++++ G A +
Sbjct: 1334 EAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRR 1393
Query: 1692 TDEEEYRNKVALLEQQVACLE--DELCESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
EEE + K AL A D L E ++ EL S A +A+ +S+
Sbjct: 1394 QLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSK 1450
>BC112391-1|AAI12392.1| 957|Homo sapiens ELKS/RAB6-interacting/CAST
family member 2 protein.
Length = 957
Score = 81.0 bits (191), Expect = 4e-14
Identities = 163/817 (19%), Positives = 332/817 (40%), Gaps = 69/817 (8%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL 374
R S +L LQ ++ EL N+ LR E K+ + ++T S E + ++ LR +
Sbjct: 143 RDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERV--LRKEE 200
Query: 375 LAAETLCEELM----DENEDMKKELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTI 428
A ++ +E M +EN+ ++ ++ L +D + + ++ + +E T
Sbjct: 201 AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTE 260
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEV----- 482
+N R L + +R+A +L + E+ L I + R+ IK+L + +
Sbjct: 261 ENFRRLQ---AEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 317
Query: 483 -ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
++S E R +AEA S+ + ++ + E + + R Q +PA+ +
Sbjct: 318 PSKSLEDDNERTRRMAEAESQVSHLEV-ILDQKEKENIHLREELHRRSQLQPEPAKT-KA 375
Query: 542 LQDSLERE----ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LQ +E + A L +R+ E+E K D++ + I ++++S +
Sbjct: 376 LQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDRE---EEIKQIEVYKSHS--- 429
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNH-MAANNLRKTAAR 656
I SK++S+ L T Q ++ + + A R +
Sbjct: 430 KFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQ 489
Query: 657 VEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
E D L L+ K+ ++++L +EK T + +MK +LE+
Sbjct: 490 TEVDALRLRLEEKESFLNKKTKQLQDL-------------TEEKGTLAGEIRDMKDMLEV 536
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT---TARRSLTTNS-- 771
E++ VL++K+E L++ KQ+ L ++ S+ S+ ++T T +L+
Sbjct: 537 KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERI 596
Query: 772 -NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
+L E+R + + ++E+ E + E+++A + +K +LI + AS +
Sbjct: 597 IERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKE-HASSLAS 655
Query: 831 VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKT 890
LKR ++ E ++ + K + + + + + N + N + K LD K+
Sbjct: 656 AGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLD---KEA 712
Query: 891 TQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXX 950
+ +E +A A++ L I ++ ++EK + + + E+ TL+ +
Sbjct: 713 SYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQ 772
Query: 951 XXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNA 1010
L+ ++ R D + LQ+++++ LE E+ A
Sbjct: 773 QLEKKKNAQLLEEVR---------RREDSMADNSQHLQIEELMNALEKTRQELDAT--KA 821
Query: 1011 GLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA 1070
L+ + + K E + +R + K E K KD N L ++ A
Sbjct: 822 RLASTQQSLAEK-EAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIAL---LELSA 877
Query: 1071 NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+K K + E L + L ++K + KL AD
Sbjct: 878 SKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
Score = 68.1 bits (159), Expect = 3e-10
Identities = 146/804 (18%), Positives = 320/804 (39%), Gaps = 60/804 (7%)
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS---VTKTSAGSNTTARRSLT 768
+L ++ + L+ +++EL+++ + L+K++ SK+ S KT R L
Sbjct: 138 MLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLR 197
Query: 769 TNS---NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS--LAQKKPKTLIKSRSL 823
+ +E+++V +E ++ + I+ +D R +L+ L Q+ + ++
Sbjct: 198 KEEAARMSVLKEQMRVSHEE-NQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI 256
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE-KLQTENKKLQLLKNAKSLRSDKA 882
+ +++ L+ + +E +LR + +E E + QT N + + +K + K
Sbjct: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 316
Query: 883 L-DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L + + + + EA +++ LE+I D+K ++ + E + + L+ +
Sbjct: 317 LPSKSLEDDNERTRRMAEAESQVSHLEVIL-DQKEKENIHLREELHRRSQ-LQPEPAKTK 374
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ ++ L+D+ Q + K L T ED E EI
Sbjct: 375 ALQTVIEMKDTKIASLERNIRDLEDEIQ------MLKANGVLNT--------EDREEEIK 420
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
++ V ++ K M KTK ID+++ +LSK +SE LQT++ L + N+
Sbjct: 421 QIEVYKSHS----KFM--KTK----IDQLKQELSKKESELL----ALQTKLETLSNQNSD 466
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
+ +V A E + L + L ++ +E+ +NK + L++ T + T++
Sbjct: 467 CKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLA-- 524
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+++N + +DK+K L + D+ K +
Sbjct: 525 -GEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSL---QTDSSNTD 580
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
+E+ LS ++ + + + + R+ + +L + + LQA + E
Sbjct: 581 TALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKE 640
Query: 1242 SKFITLEAEMRDLKA---DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPV 1298
S I L+ L + ++K+ SLE I K +LE L++ N + D +P
Sbjct: 641 SSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPE 700
Query: 1299 ---EMVEMRXXXXXXXXXXXXXQDELNN-----AKIKLEKTEAESSAAKLEMAQLKSDLA 1350
++ ++ Q E++ +++ EK + + A+LE L+
Sbjct: 701 FADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKD 760
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL-QSERKKLDRMRIAHDKDVKNKDAEL 1409
+ + + E + D+ S+ +++ + A +K + DA
Sbjct: 761 QNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATK 820
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
A L + L + A E +++ EE ++ + +L +E + EL +
Sbjct: 821 ARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKK 880
Query: 1470 VVTKARLTVEKEQAQGELLHVQKE 1493
T+ + K + + L+H K+
Sbjct: 881 KKTQEEVMALKRE-KDRLVHQLKQ 903
Score = 61.3 bits (142), Expect = 3e-08
Identities = 103/465 (22%), Positives = 192/465 (41%), Gaps = 49/465 (10%)
Query: 690 SIETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSK 748
S+E N+ + + E+ + ++++L+ E+E LR ++ Q + K K L +
Sbjct: 321 SLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAK-TKALQTV 379
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERD------CER 802
I + T S R L L V ED +E+++ + K ++
Sbjct: 380 IE-MKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQ 438
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE--ASVLRAKTQSLEADNEK 860
L ELS +K+ + L L+ QN D K+ ++V+++ A RA E D +
Sbjct: 439 LKQELS--KKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALR 496
Query: 861 LQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA--LAKIKELEMICQDEKSEK 918
L+ E K+ L K K L+ DL +K T L E+++ + ++KE ++ +K E
Sbjct: 497 LRLEEKESFLNKKTKQLQ-----DLTEEKGT-LAGEIRDMKDMLEVKERKINVLQKKIEN 550
Query: 919 -KVRFTEATKKET---DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKP 974
+ + + K+ T D +KS Q + ++ LK+ ++ +
Sbjct: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRE 610
Query: 975 RIPKKPTDLTTKLQLKKMVEDLECEIGEM---YVVMKNAGLS----GKEMTAKTK-LEKE 1026
R+ + + LK+ V L+ E+ E + +K S G + +K K LE
Sbjct: 611 RLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIA 670
Query: 1027 IDEIRSKLSK------------NDS----EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA 1070
I++ + + SK +DS EF ++ +L E + +D K + + D
Sbjct: 671 IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL 730
Query: 1071 NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
K +ENE ++ + L NK A+LK+ L+
Sbjct: 731 EILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 775
Score = 49.2 bits (112), Expect = 1e-04
Identities = 122/586 (20%), Positives = 233/586 (39%), Gaps = 50/586 (8%)
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
RRL E + EL E + +E + + L A E+ I L + +K + K L
Sbjct: 264 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDES-IKKLLEMLQSKGLPSKSL 322
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
ED +T + EA S V +E+ ++EL+ + +L+ A++ A +
Sbjct: 323 EDDNERTR--RMAEAESQVSHLEV--ILDQKEKENIHLREELHR-RSQLQPEPAKTKALQ 377
Query: 1340 LEMAQLKSDLAKLE-NXXXXXXXXXXXXXXXSSYWENKAKEL-DTDLQSERKKLDRMRIA 1397
+ + +A LE N E++ +E+ ++ K + +I
Sbjct: 378 TVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKID 437
Query: 1398 HDK-DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
K ++ K++EL L+ KL+ L + + I LK E++ E A+ + E +
Sbjct: 438 QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLK----ESLTAKEQRAAILQTEVD 493
Query: 1457 ELTGKYELLEEEHVVTKAR-----LTVEKEQAQGEL------LHV-QKELSTALGEIKTL 1504
L + L E+E + K LT EK GE+ L V +++++ +I+ L
Sbjct: 494 AL--RLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENL 551
Query: 1505 QEKLGTESA----------AWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
QE+L + + T+ + ++A+L+E L +ER + D RER
Sbjct: 552 QEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER 611
Query: 1555 --ELRA-ANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E+ + + +D+ E + E S +
Sbjct: 612 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 671
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMN-TMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
E+ K + +MN D++K L + S +R E + ++ +
Sbjct: 672 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
Query: 1671 SMAEIKN--GDKSARI-HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNT 1727
+ E++N DK +I S++ ++ KVA L+ LE + ++LL
Sbjct: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQ-LEKKK-NAQLLEEVRRR 789
Query: 1728 ELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA 1773
E +S +++ E+ + L + +E L + +AR+A +T+ LA
Sbjct: 790 EDSMADNSQHLQIEELMNALEKTRQE--LDATKARLA--STQQSLA 831
Score = 48.4 bits (110), Expect = 3e-04
Identities = 145/743 (19%), Positives = 305/743 (41%), Gaps = 73/743 (9%)
Query: 186 SIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXX 245
S+ KE+ R S +++ + T + + T+ D+N L+Q + S N +
Sbjct: 205 SVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQ-QESGNRGAEHFTIELTEENF 263
Query: 246 XXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANI 305
L+ ++E + +IE KQ L R E ++K LL L +
Sbjct: 264 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQ---TLNARDESIKK-----LLEMLQSK 315
Query: 306 DTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR 365
+K + ++ + +++ +H E + D+K+ +RE EL R
Sbjct: 316 GLPSKSLEDDNERTRRMAEAESQV-SHLEVILDQKEKENIHLRE---ELHRR-------S 364
Query: 366 QIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE 425
Q++ AK A +T+ E + +++ +RDL ++ N + D E
Sbjct: 365 QLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDR--------E 416
Query: 426 QTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQ 480
+ IK V K + K DQL+QE ++ E +LL + + + +N I+ L++
Sbjct: 417 EEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKE 476
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL- 539
+ + A LQ E+ + S + + ++ T G D +L
Sbjct: 477 SLTAKEQRAAILQTEVDALRLRLE-EKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE 535
Query: 540 ---RDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
R + ++ +L+EQLR+ +++ N K K + TD+ T T+
Sbjct: 536 VKERKINVLQKKIENLQEQLRDKDKQLTNLKD------RVKSLQTDSSNTDT--ALATLE 587
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPL-SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
++ K +E+ D L I+ +E + DL N + A K ++
Sbjct: 588 EALSEKERIIERLKEQRERDDRERLEEIESFRKENK---DLK--EKVNALQAELTEKESS 642
Query: 656 RVE--EDNESLLLQLKKMATKARSRKLS---PTPPANKLSIETANDNDEKETDEADPAEM 710
++ E SL K +K +S +++ +KL + ++ ++ +P
Sbjct: 643 LIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFA 702
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ +L ++EA+ R + + + + + L + +KE+ ++ + K A + R +
Sbjct: 703 DQIKQL-DKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQ 761
Query: 771 SNKLAE-ERVKVLEDE-----IDEVRKKLIEKERDCERLHAE--LSLAQKKPKTLIKSRS 822
+ K+A + + LE + ++EVR++ + + L E ++ +K + L +++
Sbjct: 762 NKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKA 821
Query: 823 LDASDQQNVDLKR------QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
AS QQ++ K +++ +Q +L K ++L A + L+L + K
Sbjct: 822 RLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKK 881
Query: 877 LRSDKALDLNTKKTTQLENELKE 899
++ + L +K +L ++LK+
Sbjct: 882 KTQEEVMALKREK-DRLVHQLKQ 903
Score = 48.4 bits (110), Expect = 3e-04
Identities = 119/619 (19%), Positives = 241/619 (38%), Gaps = 55/619 (8%)
Query: 167 ERVRKM-QLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQV 225
E ++K+ ++L+++ K + ER RR E E + + K+ N ++
Sbjct: 303 ESIKKLLEMLQSKGLPSKSLEDDNERTRRMA----EAESQVSHLEVILDQKEKENIHLRE 358
Query: 226 KNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQE----VD 281
+ R S L+P P ++ N+++ +D+I+ LK +
Sbjct: 359 ELHRRS-QLQPE----PAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTE 413
Query: 282 ILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDE-- 339
+ +++E KS + ID + + + SE+L LQ K+ L+ N D +
Sbjct: 414 DREEEIKQIEVYKSHSKFMK-TKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIE 472
Query: 340 --KKHLTQKIR-------EIES---ELETRPS-TEAQTRQIEQLRAKLLAAETLCEELMD 386
K+ LT K + E+++ LE + S +T+Q++ L + ++ D
Sbjct: 473 VLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD 532
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQA------DEYSSLRRELEQTIKNCRVLSFKLKK 440
E ++++ L +Q+ R+ D SL+ + T L L +
Sbjct: 533 MLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSE 592
Query: 441 TERKADQLEQEKAEHEKKLLEIVGG--PDGMQRENRIKELEQEVARSTEVALRLQRE--- 495
ER ++L++++ +++ LE + + + ++ L+ E+ + L+
Sbjct: 593 KERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASS 652
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSR--SSLTRGGSQEDPAQLLRDLQDS---LEREA 550
LA A K SL + + + S+ + L + + ED +++ + D L++EA
Sbjct: 653 LASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEA 712
Query: 551 DL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN-SIQNKMIHAAS 608
R++ A+ E ++ +K I ES T+ + QNK +
Sbjct: 713 SYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAEL---ESLTLRHMKDQNKKVANLK 769
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
EK + L + E + +L I M N L KT ++ L
Sbjct: 770 HNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELM--NALEKTRQELDATKARLASTQ 827
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEATVLRRK 727
+ +A K + + K E E + + LLEL+ + + +
Sbjct: 828 QSLAEK-EAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEE 886
Query: 728 VEELEQDKEALKKQVKELT 746
V L+++K+ L Q+K+ T
Sbjct: 887 VMALKREKDRLVHQLKQQT 905
Score = 48.4 bits (110), Expect = 3e-04
Identities = 83/484 (17%), Positives = 180/484 (37%), Gaps = 16/484 (3%)
Query: 1219 HRRLSIELTSEKDE-LQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK 1277
HRR ++ K + LQ ++K +LE +RDL+ + + + ++ IK
Sbjct: 361 HRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIK 420
Query: 1278 QLE-----DALRQTTNDKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEK 1330
Q+E +T D+ + S E ++ ++ + + K L
Sbjct: 421 QIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 480
Query: 1331 TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
E ++ + E+ L+ L + E+ + +++ L+ + +K
Sbjct: 481 KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 540
Query: 1391 LD--RMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
++ + +I + + +++KD +L LK ++K L+ +S + L++ E + +E
Sbjct: 541 INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 600
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTL 1504
+ + E + E +E+ K + L E + + L+ +++ S+
Sbjct: 601 KEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR 660
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
KL + A +K E A L++ ++ Q ++E D
Sbjct: 661 DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
+ D D ++ +Q EK + A
Sbjct: 721 KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNA 780
Query: 1625 EITDTKTRYEGQM--NTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSA 1682
++ + R E M N+ +++ L N + + R+E D K L + Q+S+AE + +
Sbjct: 781 QLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANL 840
Query: 1683 RIHR 1686
RI R
Sbjct: 841 RIER 844
Score = 45.2 bits (102), Expect = 0.002
Identities = 120/610 (19%), Positives = 257/610 (42%), Gaps = 63/610 (10%)
Query: 291 EKEKSDILLR----RLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL--- 343
+KEK +I LR R + + T + + K+ L + DL DE + L
Sbjct: 348 QKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKAN 407
Query: 344 ----TQKIREIESELETRPS-TEAQTRQIEQLR-------AKLLAAETLCEELMDENEDM 391
T+ E ++E S ++ +I+QL+ ++LLA +T E L ++N D
Sbjct: 408 GVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDC 467
Query: 392 KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
K+ + L + Q E +LR LE+ SF KKT++ D L +E
Sbjct: 468 KQHIEVLKESLTAKEQRAAILQT-EVDALRLRLEEKE------SFLNKKTKQLQD-LTEE 519
Query: 452 KAEHEKKLLEIVGGPDGMQ-RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
K ++ ++ D ++ +E +I L++++ LQ +L + + + T +
Sbjct: 520 KGTLAGEIRDM---KDMLEVKERKINVLQKKIEN-------LQEQLRDKDKQLTNLKDRV 569
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
+ Q ++ + T + + +++ L++ +RE D RE+L EE + ++ N
Sbjct: 570 KSL-QTDSSNTDTALATLEEALSEKERIIERLKE--QRERDDRERL----EEIESFRKEN 622
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
L ++V N + ++ E E+ S+ + HA+S S+ K DS S++ E+
Sbjct: 623 KD--LKEKV---NALQAELTEKES---SLIDLKEHASSLASAGLKRDSKLKSLEIAIEQK 674
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ + A+N+ + R+ + + QL K A+ R ++L
Sbjct: 675 KEECSKLEAQL---KKAHNIEDDS-RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL 730
Query: 691 IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKIS 750
+EK + AE++ L + ++ +KV L+ +++ KK+ +L ++
Sbjct: 731 EILKEVENEKNDKDKKIAELESLTLRHMKDQN---KKVANLKHNQQLEKKKNAQLLEEVR 787
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ A ++ + N+ + + + + + ++ L EKE L E
Sbjct: 788 RREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQ 847
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
++ + + L A +++ ++ L++ + + + +L+ + ++L + K Q
Sbjct: 848 LEEILEMKQEALLAAISEKDANI-ALLELSASKKKKTQEEVMALKREKDRLVHQLK--QQ 904
Query: 871 LKNAKSLRSD 880
+N L +D
Sbjct: 905 TQNRMKLMAD 914
>BC111550-1|AAI11551.1| 957|Homo sapiens ERC2 protein protein.
Length = 957
Score = 81.0 bits (191), Expect = 4e-14
Identities = 163/817 (19%), Positives = 332/817 (40%), Gaps = 69/817 (8%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL 374
R S +L LQ ++ EL N+ LR E K+ + ++T S E + ++ LR +
Sbjct: 143 RDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERV--LRKEE 200
Query: 375 LAAETLCEELM----DENEDMKKELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTI 428
A ++ +E M +EN+ ++ ++ L +D + + ++ + +E T
Sbjct: 201 AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTE 260
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEV----- 482
+N R L + +R+A +L + E+ L I + R+ IK+L + +
Sbjct: 261 ENFRRLQ---AEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 317
Query: 483 -ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
++S E R +AEA S+ + ++ + E + + R Q +PA+ +
Sbjct: 318 PSKSLEDDNERTRRMAEAESQVSHLEV-ILDQKEKENIHLREELHRRSQLQPEPAKT-KA 375
Query: 542 LQDSLERE----ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LQ +E + A L +R+ E+E K D++ + I ++++S +
Sbjct: 376 LQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDRE---EEIKQIEVYKSHS--- 429
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNH-MAANNLRKTAAR 656
I SK++S+ L T Q ++ + + A R +
Sbjct: 430 KFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQ 489
Query: 657 VEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
E D L L+ K+ ++++L +EK T + +MK +LE+
Sbjct: 490 TEVDALRLRLEEKESFLNKKTKQLQDL-------------TEEKGTLAGEIRDMKDMLEV 536
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT---TARRSLTTNS-- 771
E++ VL++K+E L++ KQ+ L ++ S+ S+ ++T T +L+
Sbjct: 537 KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERI 596
Query: 772 -NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
+L E+R + + ++E+ E + E+++A + +K +LI + AS +
Sbjct: 597 IERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKE-HASSLAS 655
Query: 831 VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKT 890
LKR ++ E ++ + K + + + + + N + N + K LD K+
Sbjct: 656 AGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLD---KEA 712
Query: 891 TQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXX 950
+ +E +A A++ L I ++ ++EK + + + E+ TL+ +
Sbjct: 713 SYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQ 772
Query: 951 XXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNA 1010
L+ ++ R D + LQ+++++ LE E+ A
Sbjct: 773 QLEKKKNAQLLEEVR---------RREDSMADNSQHLQIEELMNALEKTRQELDAT--KA 821
Query: 1011 GLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA 1070
L+ + + K E + +R + K E K KD N L ++ A
Sbjct: 822 RLASTQQSLAEK-EAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIAL---LELSA 877
Query: 1071 NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+K K + E L + L ++K + KL AD
Sbjct: 878 SKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
Score = 68.1 bits (159), Expect = 3e-10
Identities = 146/804 (18%), Positives = 320/804 (39%), Gaps = 60/804 (7%)
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS---VTKTSAGSNTTARRSLT 768
+L ++ + L+ +++EL+++ + L+K++ SK+ S KT R L
Sbjct: 138 MLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLR 197
Query: 769 TNS---NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS--LAQKKPKTLIKSRSL 823
+ +E+++V +E ++ + I+ +D R +L+ L Q+ + ++
Sbjct: 198 KEEAARMSVLKEQMRVSHEE-NQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI 256
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE-KLQTENKKLQLLKNAKSLRSDKA 882
+ +++ L+ + +E +LR + +E E + QT N + + +K + K
Sbjct: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 316
Query: 883 L-DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L + + + + EA +++ LE+I D+K ++ + E + + L+ +
Sbjct: 317 LPSKSLEDDNERTRRMAEAESQVSHLEVIL-DQKEKENIHLREELHRRSQ-LQPEPAKTK 374
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ ++ L+D+ Q + K L T ED E EI
Sbjct: 375 ALQTVIEMKDTKIASLERNIRDLEDEIQ------MLKANGVLNT--------EDREEEIK 420
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
++ V ++ K M KTK ID+++ +LSK +SE LQT++ L + N+
Sbjct: 421 QIEVYKSHS----KFM--KTK----IDQLKQELSKKESELL----ALQTKLETLSNQNSD 466
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
+ +V A E + L + L ++ +E+ +NK + L++ T + T++
Sbjct: 467 CKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLA-- 524
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+++N + +DK+K L + D+ K +
Sbjct: 525 -GEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSL---QTDSSNTD 580
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
+E+ LS ++ + + + + R+ + +L + + LQA + E
Sbjct: 581 TALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKE 640
Query: 1242 SKFITLEAEMRDLKA---DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPV 1298
S I L+ L + ++K+ SLE I K +LE L++ N + D +P
Sbjct: 641 SSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPE 700
Query: 1299 ---EMVEMRXXXXXXXXXXXXXQDELNN-----AKIKLEKTEAESSAAKLEMAQLKSDLA 1350
++ ++ Q E++ +++ EK + + A+LE L+
Sbjct: 701 FADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKD 760
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL-QSERKKLDRMRIAHDKDVKNKDAEL 1409
+ + + E + D+ S+ +++ + A +K + DA
Sbjct: 761 QNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATK 820
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
A L + L + A E +++ EE ++ + +L +E + EL +
Sbjct: 821 ARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKK 880
Query: 1470 VVTKARLTVEKEQAQGELLHVQKE 1493
T+ + K + + L+H K+
Sbjct: 881 KKTQEEVMALKRE-KDRLVHQLKQ 903
Score = 61.3 bits (142), Expect = 3e-08
Identities = 103/465 (22%), Positives = 192/465 (41%), Gaps = 49/465 (10%)
Query: 690 SIETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSK 748
S+E N+ + + E+ + ++++L+ E+E LR ++ Q + K K L +
Sbjct: 321 SLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAK-TKALQTV 379
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERD------CER 802
I + T S R L L V ED +E+++ + K ++
Sbjct: 380 IE-MKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQ 438
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE--ASVLRAKTQSLEADNEK 860
L ELS +K+ + L L+ QN D K+ ++V+++ A RA E D +
Sbjct: 439 LKQELS--KKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALR 496
Query: 861 LQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA--LAKIKELEMICQDEKSEK 918
L+ E K+ L K K L+ DL +K T L E+++ + ++KE ++ +K E
Sbjct: 497 LRLEEKESFLNKKTKQLQ-----DLTEEKGT-LAGEIRDMKDMLEVKERKINVLQKKIEN 550
Query: 919 -KVRFTEATKKET---DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKP 974
+ + + K+ T D +KS Q + ++ LK+ ++ +
Sbjct: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRE 610
Query: 975 RIPKKPTDLTTKLQLKKMVEDLECEIGEM---YVVMKNAGLS----GKEMTAKTK-LEKE 1026
R+ + + LK+ V L+ E+ E + +K S G + +K K LE
Sbjct: 611 RLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIA 670
Query: 1027 IDEIRSKLSK------------NDS----EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA 1070
I++ + + SK +DS EF ++ +L E + +D K + + D
Sbjct: 671 IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL 730
Query: 1071 NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
K +ENE ++ + L NK A+LK+ L+
Sbjct: 731 EILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 775
Score = 49.2 bits (112), Expect = 1e-04
Identities = 122/586 (20%), Positives = 233/586 (39%), Gaps = 50/586 (8%)
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
RRL E + EL E + +E + + L A E+ I L + +K + K L
Sbjct: 264 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDES-IKKLLEMLQSKGLPSKSL 322
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
ED +T + EA S V +E+ ++EL+ + +L+ A++ A +
Sbjct: 323 EDDNERTR--RMAEAESQVSHLEV--ILDQKEKENIHLREELHR-RSQLQPEPAKTKALQ 377
Query: 1340 LEMAQLKSDLAKLE-NXXXXXXXXXXXXXXXSSYWENKAKEL-DTDLQSERKKLDRMRIA 1397
+ + +A LE N E++ +E+ ++ K + +I
Sbjct: 378 TVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKID 437
Query: 1398 HDK-DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
K ++ K++EL L+ KL+ L + + I LK E++ E A+ + E +
Sbjct: 438 QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLK----ESLTAKEQRAAILQTEVD 493
Query: 1457 ELTGKYELLEEEHVVTKAR-----LTVEKEQAQGEL------LHV-QKELSTALGEIKTL 1504
L + L E+E + K LT EK GE+ L V +++++ +I+ L
Sbjct: 494 AL--RLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENL 551
Query: 1505 QEKLGTESA----------AWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
QE+L + + T+ + ++A+L+E L +ER + D RER
Sbjct: 552 QEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER 611
Query: 1555 --ELRA-ANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E+ + + +D+ E + E S +
Sbjct: 612 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 671
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMN-TMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
E+ K + +MN D++K L + S +R E + ++ +
Sbjct: 672 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
Query: 1671 SMAEIKN--GDKSARI-HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNT 1727
+ E++N DK +I S++ ++ KVA L+ LE + ++LL
Sbjct: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQ-LEKKK-NAQLLEEVRRR 789
Query: 1728 ELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA 1773
E +S +++ E+ + L + +E L + +AR+A +T+ LA
Sbjct: 790 EDSMADNSQHLQIEELMNALEKTRQE--LDATKARLA--STQQSLA 831
Score = 48.4 bits (110), Expect = 3e-04
Identities = 145/743 (19%), Positives = 305/743 (41%), Gaps = 73/743 (9%)
Query: 186 SIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXX 245
S+ KE+ R S +++ + T + + T+ D+N L+Q + S N +
Sbjct: 205 SVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQ-QESGNRGAEHFTIELTEENF 263
Query: 246 XXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANI 305
L+ ++E + +IE KQ L R E ++K LL L +
Sbjct: 264 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQ---TLNARDESIKK-----LLEMLQSK 315
Query: 306 DTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR 365
+K + ++ + +++ +H E + D+K+ +RE EL R
Sbjct: 316 GLPSKSLEDDNERTRRMAEAESQV-SHLEVILDQKEKENIHLRE---ELHRR-------S 364
Query: 366 QIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE 425
Q++ AK A +T+ E + +++ +RDL ++ N + D E
Sbjct: 365 QLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDR--------E 416
Query: 426 QTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQ 480
+ IK V K + K DQL+QE ++ E +LL + + + +N I+ L++
Sbjct: 417 EEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKE 476
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL- 539
+ + A LQ E+ + S + + ++ T G D +L
Sbjct: 477 SLTAKEQRAAILQTEVDALRLRLE-EKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE 535
Query: 540 ---RDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
R + ++ +L+EQLR+ +++ N K K + TD+ T T+
Sbjct: 536 VKERKINVLQKKIENLQEQLRDKDKQLTNLKD------RVKSLQTDSSNTDT--ALATLE 587
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPL-SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
++ K +E+ D L I+ +E + DL N + A K ++
Sbjct: 588 EALSEKERIIERLKEQRERDDRERLEEIESFRKENK---DLK--EKVNALQAELTEKESS 642
Query: 656 RVE--EDNESLLLQLKKMATKARSRKLS---PTPPANKLSIETANDNDEKETDEADPAEM 710
++ E SL K +K +S +++ +KL + ++ ++ +P
Sbjct: 643 LIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFA 702
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ +L ++EA+ R + + + + + L + +KE+ ++ + K A + R +
Sbjct: 703 DQIKQL-DKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQ 761
Query: 771 SNKLAE-ERVKVLEDE-----IDEVRKKLIEKERDCERLHAE--LSLAQKKPKTLIKSRS 822
+ K+A + + LE + ++EVR++ + + L E ++ +K + L +++
Sbjct: 762 NKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKA 821
Query: 823 LDASDQQNVDLKR------QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
AS QQ++ K +++ +Q +L K ++L A + L+L + K
Sbjct: 822 RLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKK 881
Query: 877 LRSDKALDLNTKKTTQLENELKE 899
++ + L +K +L ++LK+
Sbjct: 882 KTQEEVMALKREK-DRLVHQLKQ 903
Score = 48.4 bits (110), Expect = 3e-04
Identities = 119/619 (19%), Positives = 241/619 (38%), Gaps = 55/619 (8%)
Query: 167 ERVRKM-QLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQV 225
E ++K+ ++L+++ K + ER RR E E + + K+ N ++
Sbjct: 303 ESIKKLLEMLQSKGLPSKSLEDDNERTRRMA----EAESQVSHLEVILDQKEKENIHLRE 358
Query: 226 KNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQE----VD 281
+ R S L+P P ++ N+++ +D+I+ LK +
Sbjct: 359 ELHRRS-QLQPE----PAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTE 413
Query: 282 ILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDE-- 339
+ +++E KS + ID + + + SE+L LQ K+ L+ N D +
Sbjct: 414 DREEEIKQIEVYKSHSKFMK-TKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIE 472
Query: 340 --KKHLTQKIR-------EIES---ELETRPS-TEAQTRQIEQLRAKLLAAETLCEELMD 386
K+ LT K + E+++ LE + S +T+Q++ L + ++ D
Sbjct: 473 VLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD 532
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQA------DEYSSLRRELEQTIKNCRVLSFKLKK 440
E ++++ L +Q+ R+ D SL+ + T L L +
Sbjct: 533 MLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSE 592
Query: 441 TERKADQLEQEKAEHEKKLLEIVGG--PDGMQRENRIKELEQEVARSTEVALRLQRE--- 495
ER ++L++++ +++ LE + + + ++ L+ E+ + L+
Sbjct: 593 KERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASS 652
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSR--SSLTRGGSQEDPAQLLRDLQDS---LEREA 550
LA A K SL + + + S+ + L + + ED +++ + D L++EA
Sbjct: 653 LASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEA 712
Query: 551 DL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN-SIQNKMIHAAS 608
R++ A+ E ++ +K I ES T+ + QNK +
Sbjct: 713 SYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAEL---ESLTLRHMKDQNKKVANLK 769
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
EK + L + E + +L I M N L KT ++ L
Sbjct: 770 HNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELM--NALEKTRQELDATKARLASTQ 827
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEATVLRRK 727
+ +A K + + K E E + + LLEL+ + + +
Sbjct: 828 QSLAEK-EAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEE 886
Query: 728 VEELEQDKEALKKQVKELT 746
V L+++K+ L Q+K+ T
Sbjct: 887 VMALKREKDRLVHQLKQQT 905
Score = 48.4 bits (110), Expect = 3e-04
Identities = 83/484 (17%), Positives = 180/484 (37%), Gaps = 16/484 (3%)
Query: 1219 HRRLSIELTSEKDE-LQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK 1277
HRR ++ K + LQ ++K +LE +RDL+ + + + ++ IK
Sbjct: 361 HRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIK 420
Query: 1278 QLE-----DALRQTTNDKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEK 1330
Q+E +T D+ + S E ++ ++ + + K L
Sbjct: 421 QIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 480
Query: 1331 TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
E ++ + E+ L+ L + E+ + +++ L+ + +K
Sbjct: 481 KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 540
Query: 1391 LD--RMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
++ + +I + + +++KD +L LK ++K L+ +S + L++ E + +E
Sbjct: 541 INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 600
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTL 1504
+ + E + E +E+ K + L E + + L+ +++ S+
Sbjct: 601 KEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR 660
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
KL + A +K E A L++ ++ Q ++E D
Sbjct: 661 DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
+ D D ++ +Q EK + A
Sbjct: 721 KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNA 780
Query: 1625 EITDTKTRYEGQM--NTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSA 1682
++ + R E M N+ +++ L N + + R+E D K L + Q+S+AE + +
Sbjct: 781 QLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANL 840
Query: 1683 RIHR 1686
RI R
Sbjct: 841 RIER 844
Score = 45.2 bits (102), Expect = 0.002
Identities = 120/610 (19%), Positives = 257/610 (42%), Gaps = 63/610 (10%)
Query: 291 EKEKSDILLR----RLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL--- 343
+KEK +I LR R + + T + + K+ L + DL DE + L
Sbjct: 348 QKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKAN 407
Query: 344 ----TQKIREIESELETRPS-TEAQTRQIEQLR-------AKLLAAETLCEELMDENEDM 391
T+ E ++E S ++ +I+QL+ ++LLA +T E L ++N D
Sbjct: 408 GVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDC 467
Query: 392 KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
K+ + L + Q E +LR LE+ SF KKT++ D L +E
Sbjct: 468 KQHIEVLKESLTAKEQRAAILQT-EVDALRLRLEEKE------SFLNKKTKQLQD-LTEE 519
Query: 452 KAEHEKKLLEIVGGPDGMQ-RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
K ++ ++ D ++ +E +I L++++ LQ +L + + + T +
Sbjct: 520 KGTLAGEIRDM---KDMLEVKERKINVLQKKIEN-------LQEQLRDKDKQLTNLKDRV 569
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
+ Q ++ + T + + +++ L++ +RE D RE+L EE + ++ N
Sbjct: 570 KSL-QTDSSNTDTALATLEEALSEKERIIERLKE--QRERDDRERL----EEIESFRKEN 622
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
L ++V N + ++ E E+ S+ + HA+S S+ K DS S++ E+
Sbjct: 623 KD--LKEKV---NALQAELTEKES---SLIDLKEHASSLASAGLKRDSKLKSLEIAIEQK 674
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ + A+N+ + R+ + + QL K A+ R ++L
Sbjct: 675 KEECSKLEAQL---KKAHNIEDDS-RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL 730
Query: 691 IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKIS 750
+EK + AE++ L + ++ +KV L+ +++ KK+ +L ++
Sbjct: 731 EILKEVENEKNDKDKKIAELESLTLRHMKDQN---KKVANLKHNQQLEKKKNAQLLEEVR 787
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ A ++ + N+ + + + + + ++ L EKE L E
Sbjct: 788 RREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQ 847
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
++ + + L A +++ ++ L++ + + + +L+ + ++L + K Q
Sbjct: 848 LEEILEMKQEALLAAISEKDANI-ALLELSASKKKKTQEEVMALKREKDRLVHQLK--QQ 904
Query: 871 LKNAKSLRSD 880
+N L +D
Sbjct: 905 TQNRMKLMAD 914
>AB002376-1|BAA20832.2| 970|Homo sapiens KIAA0378 protein.
Length = 970
Score = 81.0 bits (191), Expect = 4e-14
Identities = 163/817 (19%), Positives = 332/817 (40%), Gaps = 69/817 (8%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL 374
R S +L LQ ++ EL N+ LR E K+ + ++T S E + ++ LR +
Sbjct: 156 RDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERV--LRKEE 213
Query: 375 LAAETLCEELM----DENEDMKKELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTI 428
A ++ +E M +EN+ ++ ++ L +D + + ++ + +E T
Sbjct: 214 AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTE 273
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEV----- 482
+N R L + +R+A +L + E+ L I + R+ IK+L + +
Sbjct: 274 ENFRRLQ---AEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 330
Query: 483 -ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
++S E R +AEA S+ + ++ + E + + R Q +PA+ +
Sbjct: 331 PSKSLEDDNERTRRMAEAESQVSHLEV-ILDQKEKENIHLREELHRRSQLQPEPAKT-KA 388
Query: 542 LQDSLERE----ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LQ +E + A L +R+ E+E K D++ + I ++++S +
Sbjct: 389 LQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDRE---EEIKQIEVYKSHS--- 442
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNH-MAANNLRKTAAR 656
I SK++S+ L T Q ++ + + A R +
Sbjct: 443 KFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQ 502
Query: 657 VEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
E D L L+ K+ ++++L +EK T + +MK +LE+
Sbjct: 503 TEVDALRLRLEEKESFLNKKTKQLQDL-------------TEEKGTLAGEIRDMKDMLEV 549
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT---TARRSLTTNS-- 771
E++ VL++K+E L++ KQ+ L ++ S+ S+ ++T T +L+
Sbjct: 550 KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERI 609
Query: 772 -NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
+L E+R + + ++E+ E + E+++A + +K +LI + AS +
Sbjct: 610 IERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKE-HASSLAS 668
Query: 831 VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKT 890
LKR ++ E ++ + K + + + + + N + N + K LD K+
Sbjct: 669 AGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLD---KEA 725
Query: 891 TQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXX 950
+ +E +A A++ L I ++ ++EK + + + E+ TL+ +
Sbjct: 726 SYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQ 785
Query: 951 XXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNA 1010
L+ ++ R D + LQ+++++ LE E+ A
Sbjct: 786 QLEKKKNAQLLEEVR---------RREDSMADNSQHLQIEELMNALEKTRQELDAT--KA 834
Query: 1011 GLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA 1070
L+ + + K E + +R + K E K KD N L ++ A
Sbjct: 835 RLASTQQSLAEK-EAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIAL---LELSA 890
Query: 1071 NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+K K + E L + L ++K + KL AD
Sbjct: 891 SKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 927
Score = 68.1 bits (159), Expect = 3e-10
Identities = 146/804 (18%), Positives = 320/804 (39%), Gaps = 60/804 (7%)
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS---VTKTSAGSNTTARRSLT 768
+L ++ + L+ +++EL+++ + L+K++ SK+ S KT R L
Sbjct: 151 MLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLR 210
Query: 769 TNS---NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS--LAQKKPKTLIKSRSL 823
+ +E+++V +E ++ + I+ +D R +L+ L Q+ + ++
Sbjct: 211 KEEAARMSVLKEQMRVSHEE-NQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI 269
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE-KLQTENKKLQLLKNAKSLRSDKA 882
+ +++ L+ + +E +LR + +E E + QT N + + +K + K
Sbjct: 270 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 329
Query: 883 L-DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L + + + + EA +++ LE+I D+K ++ + E + + L+ +
Sbjct: 330 LPSKSLEDDNERTRRMAEAESQVSHLEVIL-DQKEKENIHLREELHRRSQ-LQPEPAKTK 387
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ ++ L+D+ Q + K L T ED E EI
Sbjct: 388 ALQTVIEMKDTKIASLERNIRDLEDEIQ------MLKANGVLNT--------EDREEEIK 433
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
++ V ++ K M KTK ID+++ +LSK +SE LQT++ L + N+
Sbjct: 434 QIEVYKSHS----KFM--KTK----IDQLKQELSKKESELL----ALQTKLETLSNQNSD 479
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
+ +V A E + L + L ++ +E+ +NK + L++ T + T++
Sbjct: 480 CKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLA-- 537
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+++N + +DK+K L + D+ K +
Sbjct: 538 -GEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSL---QTDSSNTD 593
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
+E+ LS ++ + + + + R+ + +L + + LQA + E
Sbjct: 594 TALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKE 653
Query: 1242 SKFITLEAEMRDLKA---DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPV 1298
S I L+ L + ++K+ SLE I K +LE L++ N + D +P
Sbjct: 654 SSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPE 713
Query: 1299 ---EMVEMRXXXXXXXXXXXXXQDELNN-----AKIKLEKTEAESSAAKLEMAQLKSDLA 1350
++ ++ Q E++ +++ EK + + A+LE L+
Sbjct: 714 FADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKD 773
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL-QSERKKLDRMRIAHDKDVKNKDAEL 1409
+ + + E + D+ S+ +++ + A +K + DA
Sbjct: 774 QNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATK 833
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEH 1469
A L + L + A E +++ EE ++ + +L +E + EL +
Sbjct: 834 ARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKK 893
Query: 1470 VVTKARLTVEKEQAQGELLHVQKE 1493
T+ + K + + L+H K+
Sbjct: 894 KKTQEEVMALKRE-KDRLVHQLKQ 916
Score = 61.3 bits (142), Expect = 3e-08
Identities = 103/465 (22%), Positives = 192/465 (41%), Gaps = 49/465 (10%)
Query: 690 SIETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSK 748
S+E N+ + + E+ + ++++L+ E+E LR ++ Q + K K L +
Sbjct: 334 SLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAK-TKALQTV 392
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERD------CER 802
I + T S R L L V ED +E+++ + K ++
Sbjct: 393 IE-MKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQ 451
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE--ASVLRAKTQSLEADNEK 860
L ELS +K+ + L L+ QN D K+ ++V+++ A RA E D +
Sbjct: 452 LKQELS--KKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALR 509
Query: 861 LQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA--LAKIKELEMICQDEKSEK 918
L+ E K+ L K K L+ DL +K T L E+++ + ++KE ++ +K E
Sbjct: 510 LRLEEKESFLNKKTKQLQ-----DLTEEKGT-LAGEIRDMKDMLEVKERKINVLQKKIEN 563
Query: 919 -KVRFTEATKKET---DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKP 974
+ + + K+ T D +KS Q + ++ LK+ ++ +
Sbjct: 564 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRE 623
Query: 975 RIPKKPTDLTTKLQLKKMVEDLECEIGEM---YVVMKNAGLS----GKEMTAKTK-LEKE 1026
R+ + + LK+ V L+ E+ E + +K S G + +K K LE
Sbjct: 624 RLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIA 683
Query: 1027 IDEIRSKLSK------------NDS----EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA 1070
I++ + + SK +DS EF ++ +L E + +D K + + D
Sbjct: 684 IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL 743
Query: 1071 NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
K +ENE ++ + L NK A+LK+ L+
Sbjct: 744 EILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 788
Score = 49.2 bits (112), Expect = 1e-04
Identities = 122/586 (20%), Positives = 233/586 (39%), Gaps = 50/586 (8%)
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQL 1279
RRL E + EL E + +E + + L A E+ I L + +K + K L
Sbjct: 277 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDES-IKKLLEMLQSKGLPSKSL 335
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
ED +T + EA S V +E+ ++EL+ + +L+ A++ A +
Sbjct: 336 EDDNERTR--RMAEAESQVSHLEV--ILDQKEKENIHLREELHR-RSQLQPEPAKTKALQ 390
Query: 1340 LEMAQLKSDLAKLE-NXXXXXXXXXXXXXXXSSYWENKAKEL-DTDLQSERKKLDRMRIA 1397
+ + +A LE N E++ +E+ ++ K + +I
Sbjct: 391 TVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKID 450
Query: 1398 HDK-DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
K ++ K++EL L+ KL+ L + + I LK E++ E A+ + E +
Sbjct: 451 QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLK----ESLTAKEQRAAILQTEVD 506
Query: 1457 ELTGKYELLEEEHVVTKAR-----LTVEKEQAQGEL------LHV-QKELSTALGEIKTL 1504
L + L E+E + K LT EK GE+ L V +++++ +I+ L
Sbjct: 507 AL--RLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENL 564
Query: 1505 QEKLGTESA----------AWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
QE+L + + T+ + ++A+L+E L +ER + D RER
Sbjct: 565 QEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER 624
Query: 1555 --ELRA-ANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E+ + + +D+ E + E S +
Sbjct: 625 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 684
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMN-TMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
E+ K + +MN D++K L + S +R E + ++ +
Sbjct: 685 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 744
Query: 1671 SMAEIKN--GDKSARI-HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNT 1727
+ E++N DK +I S++ ++ KVA L+ LE + ++LL
Sbjct: 745 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQ-LEKKK-NAQLLEEVRRR 802
Query: 1728 ELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA 1773
E +S +++ E+ + L + +E L + +AR+A +T+ LA
Sbjct: 803 EDSMADNSQHLQIEELMNALEKTRQE--LDATKARLA--STQQSLA 844
Score = 48.4 bits (110), Expect = 3e-04
Identities = 145/743 (19%), Positives = 305/743 (41%), Gaps = 73/743 (9%)
Query: 186 SIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXX 245
S+ KE+ R S +++ + T + + T+ D+N L+Q + S N +
Sbjct: 218 SVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQ-QESGNRGAEHFTIELTEENF 276
Query: 246 XXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANI 305
L+ ++E + +IE KQ L R E ++K LL L +
Sbjct: 277 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQ---TLNARDESIKK-----LLEMLQSK 328
Query: 306 DTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR 365
+K + ++ + +++ +H E + D+K+ +RE EL R
Sbjct: 329 GLPSKSLEDDNERTRRMAEAESQV-SHLEVILDQKEKENIHLRE---ELHRR-------S 377
Query: 366 QIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE 425
Q++ AK A +T+ E + +++ +RDL ++ N + D E
Sbjct: 378 QLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDR--------E 429
Query: 426 QTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQ 480
+ IK V K + K DQL+QE ++ E +LL + + + +N I+ L++
Sbjct: 430 EEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKE 489
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL- 539
+ + A LQ E+ + S + + ++ T G D +L
Sbjct: 490 SLTAKEQRAAILQTEVDALRLRLE-EKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE 548
Query: 540 ---RDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
R + ++ +L+EQLR+ +++ N K K + TD+ T T+
Sbjct: 549 VKERKINVLQKKIENLQEQLRDKDKQLTNLKD------RVKSLQTDSSNTDT--ALATLE 600
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPL-SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
++ K +E+ D L I+ +E + DL N + A K ++
Sbjct: 601 EALSEKERIIERLKEQRERDDRERLEEIESFRKENK---DLK--EKVNALQAELTEKESS 655
Query: 656 RVE--EDNESLLLQLKKMATKARSRKLS---PTPPANKLSIETANDNDEKETDEADPAEM 710
++ E SL K +K +S +++ +KL + ++ ++ +P
Sbjct: 656 LIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFA 715
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ +L ++EA+ R + + + + + L + +KE+ ++ + K A + R +
Sbjct: 716 DQIKQL-DKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQ 774
Query: 771 SNKLAE-ERVKVLEDE-----IDEVRKKLIEKERDCERLHAE--LSLAQKKPKTLIKSRS 822
+ K+A + + LE + ++EVR++ + + L E ++ +K + L +++
Sbjct: 775 NKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKA 834
Query: 823 LDASDQQNVDLKR------QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
AS QQ++ K +++ +Q +L K ++L A + L+L + K
Sbjct: 835 RLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKK 894
Query: 877 LRSDKALDLNTKKTTQLENELKE 899
++ + L +K +L ++LK+
Sbjct: 895 KTQEEVMALKREK-DRLVHQLKQ 916
Score = 48.4 bits (110), Expect = 3e-04
Identities = 119/619 (19%), Positives = 241/619 (38%), Gaps = 55/619 (8%)
Query: 167 ERVRKM-QLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQV 225
E ++K+ ++L+++ K + ER RR E E + + K+ N ++
Sbjct: 316 ESIKKLLEMLQSKGLPSKSLEDDNERTRRMA----EAESQVSHLEVILDQKEKENIHLRE 371
Query: 226 KNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQE----VD 281
+ R S L+P P ++ N+++ +D+I+ LK +
Sbjct: 372 ELHRRS-QLQPE----PAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTE 426
Query: 282 ILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDE-- 339
+ +++E KS + ID + + + SE+L LQ K+ L+ N D +
Sbjct: 427 DREEEIKQIEVYKSHSKFMK-TKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIE 485
Query: 340 --KKHLTQKIR-------EIES---ELETRPS-TEAQTRQIEQLRAKLLAAETLCEELMD 386
K+ LT K + E+++ LE + S +T+Q++ L + ++ D
Sbjct: 486 VLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD 545
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQA------DEYSSLRRELEQTIKNCRVLSFKLKK 440
E ++++ L +Q+ R+ D SL+ + T L L +
Sbjct: 546 MLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSE 605
Query: 441 TERKADQLEQEKAEHEKKLLEIVGG--PDGMQRENRIKELEQEVARSTEVALRLQRE--- 495
ER ++L++++ +++ LE + + + ++ L+ E+ + L+
Sbjct: 606 KERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASS 665
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSR--SSLTRGGSQEDPAQLLRDLQDS---LEREA 550
LA A K SL + + + S+ + L + + ED +++ + D L++EA
Sbjct: 666 LASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEA 725
Query: 551 DL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN-SIQNKMIHAAS 608
R++ A+ E ++ +K I ES T+ + QNK +
Sbjct: 726 SYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAEL---ESLTLRHMKDQNKKVANLK 782
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
EK + L + E + +L I M N L KT ++ L
Sbjct: 783 HNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELM--NALEKTRQELDATKARLASTQ 840
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEATVLRRK 727
+ +A K + + K E E + + LLEL+ + + +
Sbjct: 841 QSLAEK-EAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEE 899
Query: 728 VEELEQDKEALKKQVKELT 746
V L+++K+ L Q+K+ T
Sbjct: 900 VMALKREKDRLVHQLKQQT 918
Score = 48.4 bits (110), Expect = 3e-04
Identities = 83/484 (17%), Positives = 180/484 (37%), Gaps = 16/484 (3%)
Query: 1219 HRRLSIELTSEKDE-LQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK 1277
HRR ++ K + LQ ++K +LE +RDL+ + + + ++ IK
Sbjct: 374 HRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIK 433
Query: 1278 QLE-----DALRQTTNDKYDEATSPVE--MVEMRXXXXXXXXXXXXXQDELNNAKIKLEK 1330
Q+E +T D+ + S E ++ ++ + + K L
Sbjct: 434 QIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 493
Query: 1331 TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
E ++ + E+ L+ L + E+ + +++ L+ + +K
Sbjct: 494 KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 553
Query: 1391 LD--RMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
++ + +I + + +++KD +L LK ++K L+ +S + L++ E + +E
Sbjct: 554 INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 613
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTL 1504
+ + E + E +E+ K + L E + + L+ +++ S+
Sbjct: 614 KEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR 673
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
KL + A +K E A L++ ++ Q ++E D
Sbjct: 674 DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 733
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
+ D D ++ +Q EK + A
Sbjct: 734 KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNA 793
Query: 1625 EITDTKTRYEGQM--NTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSA 1682
++ + R E M N+ +++ L N + + R+E D K L + Q+S+AE + +
Sbjct: 794 QLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANL 853
Query: 1683 RIHR 1686
RI R
Sbjct: 854 RIER 857
Score = 45.2 bits (102), Expect = 0.002
Identities = 120/610 (19%), Positives = 257/610 (42%), Gaps = 63/610 (10%)
Query: 291 EKEKSDILLR----RLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL--- 343
+KEK +I LR R + + T + + K+ L + DL DE + L
Sbjct: 361 QKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKAN 420
Query: 344 ----TQKIREIESELETRPS-TEAQTRQIEQLR-------AKLLAAETLCEELMDENEDM 391
T+ E ++E S ++ +I+QL+ ++LLA +T E L ++N D
Sbjct: 421 GVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDC 480
Query: 392 KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
K+ + L + Q E +LR LE+ SF KKT++ D L +E
Sbjct: 481 KQHIEVLKESLTAKEQRAAILQT-EVDALRLRLEEKE------SFLNKKTKQLQD-LTEE 532
Query: 452 KAEHEKKLLEIVGGPDGMQ-RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
K ++ ++ D ++ +E +I L++++ LQ +L + + + T +
Sbjct: 533 KGTLAGEIRDM---KDMLEVKERKINVLQKKIEN-------LQEQLRDKDKQLTNLKDRV 582
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
+ Q ++ + T + + +++ L++ +RE D RE+L EE + ++ N
Sbjct: 583 KSL-QTDSSNTDTALATLEEALSEKERIIERLKE--QRERDDRERL----EEIESFRKEN 635
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
L ++V N + ++ E E+ S+ + HA+S S+ K DS S++ E+
Sbjct: 636 KD--LKEKV---NALQAELTEKES---SLIDLKEHASSLASAGLKRDSKLKSLEIAIEQK 687
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ + A+N+ + R+ + + QL K A+ R ++L
Sbjct: 688 KEECSKLEAQL---KKAHNIEDDS-RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL 743
Query: 691 IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKIS 750
+EK + AE++ L + ++ +KV L+ +++ KK+ +L ++
Sbjct: 744 EILKEVENEKNDKDKKIAELESLTLRHMKDQN---KKVANLKHNQQLEKKKNAQLLEEVR 800
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ A ++ + N+ + + + + + ++ L EKE L E
Sbjct: 801 RREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQ 860
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
++ + + L A +++ ++ L++ + + + +L+ + ++L + K Q
Sbjct: 861 LEEILEMKQEALLAAISEKDANI-ALLELSASKKKKTQEEVMALKREKDRLVHQLK--QQ 917
Query: 871 LKNAKSLRSD 880
+N L +D
Sbjct: 918 TQNRMKLMAD 927
>AL121586-4|CAB89415.1| 2442|Homo sapiens centrosomal protein 250kDa
protein.
Length = 2442
Score = 80.6 bits (190), Expect = 5e-14
Identities = 154/859 (17%), Positives = 352/859 (40%), Gaps = 51/859 (5%)
Query: 267 KEYQDQIEGLKQEVDILR-KRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
++Y+ I+ L++ V+IL E +E E S L R A + + + + +++
Sbjct: 300 EDYEKMIKALRETVEILETNHTELMEHEAS---LSRNAQEEKLSLQQVIKDITQVMVEEG 356
Query: 326 VN--ELTTHNEDLRDEKKHLTQ-KIREIESELETRPSTEAQTRQ-IEQLRAKLLAAETLC 381
N + + H L + +Q ++ + L S + RQ ++ LR +L +
Sbjct: 357 DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV 416
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
L +++ ++E + L + R+ A + L+ E++ K +L ++
Sbjct: 417 NLLQQQHDQWEEEGKALRQRLQKLTGE-RDTLAGQTVDLQGEVDSLSKERELLQKAREEL 475
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
++ + LEQE + +E+ D Q + +E ++E+ + RLQ L +
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK--EEQQEELHLAVRERERLQEMLMGLEA 533
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE---READLREQLRN 558
K + S L+ + + L R E A L R Q E E L+ ++ +
Sbjct: 534 KQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD 593
Query: 559 AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDS 618
+N LDK + ++ + E S+ ++M A ++ + +
Sbjct: 594 LRAAAVKLSALNEALALDKVGLNQQLL-----QLEEENQSVCSRMEAAEQARNALQVDLA 648
Query: 619 PPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSR 678
+ E H + A L+ ++E+ E +++K +++R +
Sbjct: 649 EAEKRREALWEKNTHLEAQLQKA--EEAGAELQADLRDIQEEKE----EIQKKLSESRHQ 702
Query: 679 KLSPTPPANKLSIETANDND-------EKETDEADPAEMKLLLELNEQEATVLRRKVEEL 731
+ + T +L E + EKE + A +++ L+ E++ L +++ L
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
KE L+ + E + +SV + + G +++T + ++ + V+ L+ E+D R
Sbjct: 763 SSAKELLESSLFEAQQQ-NSVIEVTKGQLEVQIQTVT-QAKEVIQGEVRCLKLELDTERS 820
Query: 792 KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK- 850
+ E+ERD +L+ A+++ KT ++ + A+ ++ V+ R+ E+E S + +
Sbjct: 821 QA-EQERDAAA--RQLAQAEQEGKTALEQQK--AAHEKEVNQLREKW--EKERSWHQQEL 873
Query: 851 TQSLEA-DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEM 909
++LE+ + EK++ E + + +++++ + + ++ + +L+ ++ LE
Sbjct: 874 AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLET 933
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
+ Q +K +A+++ + + Q LK +
Sbjct: 934 LLQTQKE-----LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
+ + L K+ L+K VEDL+ ++ + L +E+ K + +E +
Sbjct: 989 DDLAALQEESSSLLQDKMDLQKQVEDLK---SQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045
Query: 1030 IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKT 1089
I+ +L + + T + + L++ ++ + + + + E LS Q +
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105
Query: 1090 LTEEMKNREAQINKLSADL 1108
L +E+K +EA A L
Sbjct: 1106 LRQEVKEKEADFLAQEAQL 1124
Score = 80.2 bits (189), Expect = 7e-14
Identities = 238/1355 (17%), Positives = 540/1355 (39%), Gaps = 89/1355 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
V+ + ++ +Q++GL ++L +++ S I + + ++ + T ++ EV++
Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK-GQLEVQIQTVT-QAKEVIQ 805
Query: 322 LQQKVN--ELTTHNEDLRDEKKHLTQKIREIESELETRPSTE--AQTRQIEQLRAKLLAA 377
+ + EL T E+ +++ + E E +T + A +++ QLR K
Sbjct: 806 GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWE-- 863
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSF 436
+E +++ K L L ++ +E Q + E +RE E+T +
Sbjct: 864 ----KERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL-EQEVARSTEVALR-LQR 494
+L+ TE++ L + + +K+L + + ++++ ++++L EQE + L+ QR
Sbjct: 920 QLE-TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED-PAQLLRDLQDSLER--EAD 551
EL EA + +L Q E+ + + + ED +QL+ QD +R E +
Sbjct: 979 ELKEAARQHRDDLAAL----QEESSSLLQDKMDLQKQVEDLKSQLVA--QDDSQRLVEQE 1032
Query: 552 LREQLRNAEEETANCKQVN-PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
++E+LR +E K++ L +M + E++++ + +
Sbjct: 1033 VQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEA 1092
Query: 611 SSKEKSDSPPLSI-DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE---EDNESLLL 666
++K S + + + +E + F + + A+++ + R ++ ++ L
Sbjct: 1093 QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL 1152
Query: 667 QLKKMATKARSRKLSPTP-PANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
QL+ +T+++ L+ P N+ + + +A + + EL+ +
Sbjct: 1153 QLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA-- 1210
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
V LE D+ + L + +T SA + +A L + K + R VL D+
Sbjct: 1211 PSVWGLEPDQNG----ARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTR-DVLRDQ 1265
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ ++ ++L + E + ++H EL Q++ + +S +QN L+ +L + + +
Sbjct: 1266 VQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS-KWEGKQN-SLESELMELHETMA 1323
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD--KALDLNTKKTTQLENELKEALAK 903
L+++ + E + Q E + LQ K + + + +A + + L+E L
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT 1383
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
+ + +E ++ R +A +++ + LK Q + +++
Sbjct: 1384 ARSALKLKNEEVESERER-AQALQEQGE-LKVAQ--GKALQENLALLTQTLAEREEEVET 1439
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
L+ Q+ K R +K L LKK ++++ + ++ + K + A +
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
E+++ R ++ + + + ++N L+ ++ +L+ + +E + + + L+ + L
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR----GQVQDLKKQLVTL 1555
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
L E E Q KL +L+ Q +
Sbjct: 1556 ECLALELEENHHKMECQ-QKLIKELEGQRETQRV---ALTHLTLDLEERSQELQAQSSQI 1611
Query: 1144 XQVDNY-TKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV---- 1198
++++ T + ++ + +EV + ++I + +R +++L +K+R+
Sbjct: 1612 HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + R ELT+++ +Q R + + + +K
Sbjct: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 1259 ENKITSLESTIAAKDVH-IKQLEDALRQT---TNDKYDEATSPVEMVEMRXXXXXXXXXX 1314
+K +E + +H +++L+D L Q + K E + + E
Sbjct: 1732 RDKEKEVE--CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 1315 XXXQDELNNAKIKLEKTEAESSAA----KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXS 1370
Q EL ++ + EA+ + A +LE Q + A+ +
Sbjct: 1790 AREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQ 1849
Query: 1371 SYWENKAKELD-TDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
++ K + + D + + ++L+ + V+ + L L+ + + E+ A ++
Sbjct: 1850 AHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQ 1909
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEE-----HVVTKARLTVEKEQ-- 1482
E QE+E + L+ S +A +E + E L E H AR E Q
Sbjct: 1910 CAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEA 1969
Query: 1483 -------AQGELLHV--QKELSTAL-GEIKTLQEKLGTESAAWNTEKTEMQNSIASLQER 1532
QG+ H+ Q ELS +L TLQ L A + ++ +Q++
Sbjct: 1970 LGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQ 2029
Query: 1533 LCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
++ + +L L QR+ ELR +R +LE
Sbjct: 2030 --DLRYQEDVQQLQQALAQRDEELRHQQEREQLLE 2062
Score = 63.3 bits (147), Expect = 9e-09
Identities = 93/450 (20%), Positives = 194/450 (43%), Gaps = 22/450 (4%)
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVL 724
LLQL++ SR + N L ++ A +E ++ L+ E+ L
Sbjct: 619 LLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAEL 678
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLED 784
+ + +++++KE ++K++ E + + T + A+R + + E+ V E
Sbjct: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK 738
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
EVR + +E++R + L AE K L++S SL + QQN VIE
Sbjct: 739 AALEVRLQAVERDR--QDL-AEQLQGLSSAKELLES-SLFEAQQQN-------SVIEVTK 787
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
L + Q++ E +Q E + L+L + + ++++ D ++ Q E E K AL +
Sbjct: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847
Query: 905 K---ELEMICQDEKSEKKVRF-TEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
K E E+ EK EK+ + + K ++L+ ++ +
Sbjct: 848 KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE 907
Query: 961 LKSLKDDAQKSFKPRIPKKPTD-LTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTA 1019
++ + A + K+ L T LQ +K + D ++ + MK L +E T
Sbjct: 908 ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTG 967
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
L+ ++ E + +L + + ++ LQ E + L + K++ K V K + + +
Sbjct: 968 --ILQTQLQEAQRELKEAARQHRDDLAALQEESSSL--LQDKMDLQKQVEDLKSQLVAQD 1023
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+S + + + E+++ + + N++ +L+
Sbjct: 1024 DSQRLVE-QEVQEKLRETQ-EYNRIQKELE 1051
Score = 63.3 bits (147), Expect = 9e-09
Identities = 139/689 (20%), Positives = 293/689 (42%), Gaps = 72/689 (10%)
Query: 277 KQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDL 336
++EV+ LR + + +EK++ + A ++ + R+ EV Q+++ EL E
Sbjct: 1434 EEEVETLRGQIQELEKQRE----MQKAALELLSLDLKKRNQEVDLQQEQIQEL----EKC 1485
Query: 337 RDEKKHLTQKIREIESEL--------ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDEN 388
R +HL ++E E +L E E Q +E +L + + E +
Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545
Query: 389 EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
+D+KK+L L +++N + + + L +ELE + RV L ++
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQ--KLIKELEGQRETQRV---ALTHLTLDLEER 1600
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
QE ++ ++ + RE ++E +QEV E LQR+ +
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLARE--LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ 1658
Query: 509 SLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQDSLEREADLREQL--RNAEEETA 564
LM Q E ++V TR +ED Q+ L++ RE + QL AEE
Sbjct: 1659 ELML--QKERIQVLEDQRTRQTKILEEDLEQIKLSLRER-GRELTTQRQLMQERAEEGKG 1715
Query: 565 NCKQVNPPTFLDKQVMTD--NIVTCD---IHESETVTNSIQNKM--IH--AASTPSSKEK 615
K K ++ D V C IHE + + + ++ ++ +H T +
Sbjct: 1716 PSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQ 1775
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
+ + + + +E + +L S+ + + A + D E LQ ++ +
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLD----EAQRALAQRDQELEALQQEQQQAQG 1831
Query: 676 RSRKLSPTPPANKLSIETANDN-DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
+ ++ A + ++E A+ E+ + D E L E+E V R+V+ LE+
Sbjct: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRL---EEELAVEGRRVQALEEV 1888
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L+ + +E + ++ + A + E + L+D + + L
Sbjct: 1889 LGDLRAESREQEKALLALQQQCA------------EQAQEHEVETRALQDSWLQAQAVLK 1936
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRS---LDASDQQNVDLKRQLQVIEQEASV---LR 848
E++++ E L AE S + + + ++R+ +A + + L+ + Q + ++A + L
Sbjct: 1937 ERDQELEALRAE-SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE 1995
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
A T +L+A + Q +++L+ A ++ + D + + ++ +L++ALA+ ++ E
Sbjct: 1996 ASTATLQASLDACQAHSRQLE---EALRIQEGEIQDQDLRYQEDVQ-QLQQALAQ-RDEE 2050
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ Q E+ E+ + + A + + + ++ KQ
Sbjct: 2051 LRHQQER-EQLLEKSLAQRVQENMIQEKQ 2078
Score = 56.0 bits (129), Expect = 1e-06
Identities = 113/579 (19%), Positives = 221/579 (38%), Gaps = 49/579 (8%)
Query: 1213 VVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK 1272
V LA +R L + L+A+ K E L+A++RD++ + E L + +
Sbjct: 645 VDLAEAEKRREA-LWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ 703
Query: 1273 DVHIKQLEDALRQTTNDKYDEATSPVEMVE--MRXXXXXXXXXXXXXQDELNNAKIKLEK 1330
+ QLE L Q + + V+ E +R +D + A+ +L+
Sbjct: 704 EAATTQLEQ-LHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE-QLQG 761
Query: 1331 TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
+ + + + + + +E + + + L +L +ER +
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ 821
Query: 1391 LDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEE--TVKKLEHSL 1448
++ R A + + + E GK LEQ A K + +L++++E+ + + E +
Sbjct: 822 AEQERDAAARQLAQAEQE-----GKTA-LEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
ALE E E++ + L E++ + + E+E+ Q E Q +L T + L+ L
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 1509 GTE----SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
T+ A+ E+ + L+E+ G L +L + +REL+ A
Sbjct: 936 QTQKELADASQQLERLRQDMKVQKLKEQETTG-------ILQTQLQEAQRELKEA----- 983
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
H D D K+ + + E K
Sbjct: 984 -ARQHRDDLAALQEESSSLLQD-----KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037
Query: 1625 EITDTKTRYEGQMNTMRDELK-SLHNQVSRF--RRERDNYKQM-LEAAQKSMAEIKNGDK 1680
T R + ++ + L SL + R +E D+ +Q L A ++ M E + K
Sbjct: 1038 RETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK 1097
Query: 1681 SARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA---E 1737
+ +E + K A Q A L +EL S + +L L ++++ A +
Sbjct: 1098 ELSAQMELL----RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
Query: 1738 VRLAEMQSRLNEYEEERL---LSSGRARVAGLATRMELA 1773
+RL +S+L E+ + +A++A L + ++ A
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Score = 44.8 bits (101), Expect = 0.003
Identities = 119/605 (19%), Positives = 243/605 (40%), Gaps = 50/605 (8%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDL----------KADYENKITSLESTIAAKDVH 1275
L + +L+ R TE++ + E++DL K+ +E K SLES +
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVE-----MRXXXXXXXXXXXXXQDELNNAKIKLEK 1330
+ L+ LR+ + EA E+++ + + + + A I E
Sbjct: 1322 MASLQSRLRRAELQRM-EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 1331 TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
SA KL+ +++S+ E + EN A T L ++
Sbjct: 1381 LRTARSALKLKNEEVESER---ERAQALQEQGELKVAQGKALQENLALLTQT-LAEREEE 1436
Query: 1391 LDRMRIAHDKDVKNKDAELATLKG-KLKILEQNSGAGAKRITELKQEYEETVKKLEH-SL 1448
++ +R + K ++ + A L+ L + ++N ++ E QE E+ LEH +
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ--EQIQELEKCRSVLEHLPM 1494
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKE---LSTALGEIKTLQ 1505
A+++ E ++LT + E + E + K R T ++ + +LL ++K+ + + G+++ L+
Sbjct: 1495 AVQERE-QKLTVQREQIRE---LEKDRET-QRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549
Query: 1506 EKLGT-ESAAWNTEKTEMQNSIASLQERLCGGGWEVERA---RLNARLDQRERELRAAND 1561
++L T E A E+ + + G E +R L L++R +EL+A +
Sbjct: 1550 KQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSS 1609
Query: 1562 RRDVLEHHHDXXXXXXXXXXXXXXDY-ERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEK 1620
+ LE H E++ ++QR E+ +
Sbjct: 1610 QIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV 1669
Query: 1621 ARKAEITDTKTRYEG--QMN-TMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN 1677
TK E Q+ ++R+ + L Q + + K +A + S+ +K
Sbjct: 1670 LEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL 1729
Query: 1678 --GDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSS 1735
DK + + +E +++ LEQQ+ L ++ E+ LL S+ E+V +
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKDQ---LEQQLQGLHRKVGETSLLLSQREQEIVVLQQ- 1785
Query: 1736 AEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERD---EQQRLLQETSTLA 1792
+++ A Q L E + L + +A +E +++ +++R+ ++ L
Sbjct: 1786 -QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQ 1844
Query: 1793 RDLRQ 1797
L Q
Sbjct: 1845 GALEQ 1849
Score = 41.1 bits (92), Expect = 0.039
Identities = 70/331 (21%), Positives = 130/331 (39%), Gaps = 31/331 (9%)
Query: 1250 EMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
E +L E +L++++ A H +QLE+ALR + D+ E V+
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALA 2045
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
Q E LEK+ A+ + M Q K +L +
Sbjct: 2046 QRDEELRHQQEREQL---LEKSLAQ--RVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAK 1428
+ + + + L+ +R L+ + +H ++ + +L +L+ +L+ E A
Sbjct: 2101 LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQ-RELERLQAAL 2159
Query: 1429 RITELKQ-EYEETVKKLEHSLALEKAEYEEL--------------TGKYELLEEEHVVTK 1473
R TE ++ E+ E + L SLA KA L + + L++E +T+
Sbjct: 2160 RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTR 2219
Query: 1474 ARLTVEKEQAQGEL----LHVQKELSTALGEIKTLQEKL---GTESAAWNTEKTEMQNSI 1526
L E+ + G L + E LGE+ ++ + G E +W +Q ++
Sbjct: 2220 RALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAV 2279
Query: 1527 ASLQERLCGGGWEVERARLNARLDQRERELR 1557
A L+ + + +L + L+Q ERE R
Sbjct: 2280 ARLE--IDRSRLQRHNVQLRSTLEQVERERR 2308
Score = 36.3 bits (80), Expect = 1.1
Identities = 41/164 (25%), Positives = 78/164 (47%), Gaps = 16/164 (9%)
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKS-------ARIHRNS 1688
++ T+R+ L+S H + R+E+ L A++S+AE+ + + + R
Sbjct: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600
Query: 1689 ISSTDEEEYRNKVALLEQQVACLEDE---LCESRLLASKLNTELVSEKSSAEVRLAEMQS 1745
+S+ +E +KV L QQ+ LE+E +C A + L + + AE R +
Sbjct: 601 LSALNEALALDKVG-LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659
Query: 1746 RLNEYEEERLLSSGRARVAGLATRMELA-WHKERDEQQRLLQET 1788
+ N + E +L +A AG + +L +E++E Q+ L E+
Sbjct: 660 K-NTHLEAQL---QKAEEAGAELQADLRDIQEEKEEIQKKLSES 699
Score = 35.5 bits (78), Expect = 2.0
Identities = 42/166 (25%), Positives = 76/166 (45%), Gaps = 8/166 (4%)
Query: 1406 DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELL 1465
+ E L+ +L+ L A + +L+ E + K+ E L+KA EEL + E+L
Sbjct: 427 EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERE---LLQKAR-EELRQQLEVL 482
Query: 1466 EEEHVVTK---ARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEM 1522
E+E + L ++ + AQG+ Q+EL A+ E + LQE L A + +E+
Sbjct: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
Query: 1523 QNSIASLQ-ERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+L+ L G E+ + A L + E+ + + + L+
Sbjct: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLK 588
>U25725-1|AAA86889.1| 1017|Homo sapiens AH antigen protein.
Length = 1017
Score = 80.2 bits (189), Expect = 7e-14
Identities = 172/813 (21%), Positives = 342/813 (42%), Gaps = 61/813 (7%)
Query: 323 QQKVNELTTHNEDLR-----DEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
Q++V++L E LR DEKK H+ +K++E + E ++ ++E L +L
Sbjct: 14 QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERDGE------NDSLKDKVENLERELQ 67
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+E E ++ + E+ K E+ L M + + + D +LR E E K +
Sbjct: 68 MSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD-LVTLRSEKENLTKQIQEKQ 126
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR--ENRIKELEQEVARSTEVALRLQ 493
+L + ++ + + E E+ ++I +N++KEL + VA AL
Sbjct: 127 GQLSELDKLLSSFKSQLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVA-----ALCGD 181
Query: 494 RELAEANSKFTGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+E+ +A + +P + + Q +++ R+ L ++ +L+ L++S E ADL
Sbjct: 182 QEIMKATEQ--SLDPPIEEEHQLRNSIEKLRARLE--ADEKKQLCVLQQLKES-EHHADL 236
Query: 553 -REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPS 611
+ ++ N E E + L+ + + T + E +T S++ + + S
Sbjct: 237 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA-KIEGMTQSLRGLELDVVTIRS 295
Query: 612 SKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR-KTAARVE-EDNESLLLQLK 669
KE D T E + + L I N N L+ K +V+ ++ S +++
Sbjct: 296 EKE---------DLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEML 346
Query: 670 KMATKARSRKLSPTPPANK-LSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
+ K+ R+ P K +S + N + + E E + A++ L+ + VL+ V
Sbjct: 347 QTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSV 406
Query: 729 EELEQDKEALKKQVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
L Q+ E K+++++ +IS + + ++ S ++L +E+ L +
Sbjct: 407 NGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV 466
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN-VDLKRQLQV----IEQ 842
E+ +K+ + L L + Q K L L D+ + V+ ++ +++
Sbjct: 467 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 526
Query: 843 EASVLRAKTQSL--EADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
E + KT L E EK + + LL+ KS + D+ +L T + ++L+ L
Sbjct: 527 EMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK-DQLKEL-TLENSELKKSLDCM 584
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKET----DTLKSKQXXXXXXXXXXXXXXXXXXX 956
E E ++E +E ++R EA KK DT K +
Sbjct: 585 HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSS 644
Query: 957 XQAT---LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLS 1013
+ LKS K++ S K TK+ K V L+ E MK S
Sbjct: 645 QKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKS 704
Query: 1014 GKEMTAKTK-LEKEIDEIRS--KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA 1070
K++ + + L+KE+ ++++ + K + + + L TEI +LK+ + + D +
Sbjct: 705 CKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYL 764
Query: 1071 NKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
+KY +L + L + L ++ + +Q +K
Sbjct: 765 DKYCSLLISHEKLEKAKEMLETQVAHLCSQQSK 797
Score = 80.2 bits (189), Expect = 7e-14
Identities = 137/706 (19%), Positives = 287/706 (40%), Gaps = 47/706 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ +KE + + LK +V+ L + + E+ + ++L A A T E +
Sbjct: 41 IAEKLKERDGENDSLKDKVENLERELQMSEENQELVILD--AENSKAEVETLKTQIEEMA 98
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESEL----ETRPSTEAQTRQIEQLRAKL--- 374
KV EL LR EK++LT++I+E + +L + S ++Q + EQ ++
Sbjct: 99 RSLKVFELDLVT--LRSEKENLTKQIQEKQGQLSELDKLLSSFKSQLEEKEQAEIQIKEE 156
Query: 375 --LAAETLCEELMDENEDMKKELRD---LXXXXXXMQDNFREDQA--DEYSSLRRELEQT 427
A E L +L + NE + D + + E+ + LR LE
Sbjct: 157 SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 216
Query: 428 IKNCRVLSFKLKKTERKADQLEQ--EKAEHEKKLLEIVGGPDGMQREN---RIKELEQEV 482
K + +LK++E AD L+ E E E ++ ++ EN ++ L+ ++
Sbjct: 217 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 276
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP-ETVKVSRSSLTRGGSQEDPAQLLRD 541
T+ L+ ++ S+ L K + +++ SS +++ ++
Sbjct: 277 EGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 336
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---S 598
+ S E L+ QL+++ E C P +Q ++ + ++ +++ + +
Sbjct: 337 EKSSTAMEM-LQTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVECLELEKAQLLQGLDEA 395
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEE-----TQFHFDLPYLSIFNHMAANNLRKT 653
N ++ +S ++ + ++K EE Q +S + + +
Sbjct: 396 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 455
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+E N ++ L+ K ++++ L T ++++ N E E + +M +
Sbjct: 456 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEV----LQSSYKNLENELELTKMDKMSFV 511
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
++N+ A K EL+++ + ++ EL ++S AG + ++ ++
Sbjct: 512 EKVNKMTA-----KETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 566
Query: 774 LAEERVK--VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
L E ++ L+ +D + K +EKE AE L + + ++ LD + Q V
Sbjct: 567 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 626
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL-NTKKT 890
+++ + + + L +Q LE D K E L + L K + N K
Sbjct: 627 EIQTYREKLTSKEECL--SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYV 684
Query: 891 TQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
QL+ E + A K+K L C+ + EK++ E ++ + K K
Sbjct: 685 NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK 730
Score = 65.3 bits (152), Expect = 2e-09
Identities = 102/514 (19%), Positives = 211/514 (41%), Gaps = 52/514 (10%)
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDE--- 699
H + K R+E D + L +K+ + + L + ++ + +N E
Sbjct: 18 HQLRRGIEKLRVRIEADEKKQLHIAEKLKERDGENDSLKDKVENLERELQMSEENQELVI 77
Query: 700 --KETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK--T 755
E +A+ +K +E + V + L +KE L KQ++E ++S + K +
Sbjct: 78 LDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLS 137
Query: 756 SAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKL--------------------IE 795
S S + + ++ V++L++++ E+ + + IE
Sbjct: 138 SFKSQLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIE 197
Query: 796 KERDC----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+E E+L A L +KK +++ L S+ LK +++ +E+E + R
Sbjct: 198 EEHQLRNSIEKLRARLEADEKKQLCVLQQ--LKESEHHADLLKGRVENLERELEIARTNQ 255
Query: 852 Q--SLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ--LENELKEALAKIKEL 907
+ +LEA+N K + E K ++ +SLR + LD+ T ++ + L NEL++ +I EL
Sbjct: 256 EHAALEAENSKGEVETLKAKIEGMTQSLRGLE-LDVVTIRSEKEDLTNELQKEQERISEL 314
Query: 908 EMICQD------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
E+I EK ++KV+ E + + L+++ + L
Sbjct: 315 EIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQPCIMTKKPVSAKEQNL 374
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL--ECEIGEMYVVMKNAGLSG--KEM 1017
S + + + + L+ V L E E G+ + K+ +S ++
Sbjct: 375 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 434
Query: 1018 TAKTKLEKEIDEIRSK---LSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK 1074
+ +L ++ ++ + + + E N L+ +I L+ NA L+ +V + YK
Sbjct: 435 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 494
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
LENE + E++ A+ +L ++
Sbjct: 495 NLENELELTKMDKMSFVEKVNKMTAKETELQREM 528
Score = 64.9 bits (151), Expect = 3e-09
Identities = 152/768 (19%), Positives = 316/768 (41%), Gaps = 67/768 (8%)
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ ++++ + R E+L + +KK + + L D +N LK +++ +E+E
Sbjct: 10 LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHI--AEKLKERDGENDSLKDKVENLERELQ 67
Query: 846 VLRAKTQS--LEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ--LENELKEAL 901
+ + L+A+N K + E K Q+ + A+SL+ + LDL T ++ + L +++E
Sbjct: 68 MSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFE-LDLVTLRSEKENLTKQIQEKQ 126
Query: 902 AKIKELEMICQDEKS--EKKVRFTEATKKETDT-LKSKQXXXXXXXXXXXXXXXXXXXXQ 958
++ EL+ + KS E+K + K+E+ T ++ Q +
Sbjct: 127 GQLSELDKLLSSFKSQLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 186
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
AT +SL ++ + R + + KK + C + ++ +A L +
Sbjct: 187 ATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQL----CVLQQLKESEHHADLLKGRVE 242
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG---DKDVFANKYKA 1075
LE+E++ R+ E N K ++T AK++ + L G D ++ +
Sbjct: 243 ---NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKED 299
Query: 1076 LENE---NSNLSNQCKTLTEEMKN--REAQINKLSADLKNATS---LQTTMSDCMXXXXX 1127
L NE ++ + + +N +E + K+ K++T+ LQT + M
Sbjct: 300 LTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQP 359
Query: 1128 XXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRI 1187
QV+ ++ +K +LL+ + D+ K + + +
Sbjct: 360 CIMTKKPVSAKEQNLSSQVEC---LELEKAQLLQGL-DEAKN--NYIVLQSSVNGLIQEV 413
Query: 1188 E--KQLSTRKDRVTXXXXXXXXXXXQAVV----LANTH---RRLSIELTSEKDELQARFI 1238
E KQ +KD Q V + H + ++EL + EL+ +
Sbjct: 414 EDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQ 473
Query: 1239 KTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTT---NDKYDEAT 1295
+SK +L+ + L++ Y+N LE T K ++++ + T + ++ A
Sbjct: 474 VLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQ 533
Query: 1296 SPVEM-VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLEN 1354
E+ E+ +E+ ++K +L++ E+S K + + D + E
Sbjct: 534 KTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEG 593
Query: 1355 XXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERK-KLDRMRIAHDKD-VKNKDAELATL 1412
+ +++A LDT+ Q E + + R ++ ++ + ++ E+ L
Sbjct: 594 KVREEIAEYQLRLHEAEK-KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLL 652
Query: 1413 KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL-------L 1465
K + L + A + + ELK+ + +K + K E E GK +L L
Sbjct: 653 KSSKEELNNSLKATTQILEELKKTKMDNLKYVNQL----KKENERAQGKMKLLIKSCKQL 708
Query: 1466 EEEHVVTKARLT----VEKEQAQGELLHVQ-KELSTALGEIK-TLQEK 1507
EEE + + L+ +++Q G ++ + EL+T + E+K TL+EK
Sbjct: 709 EEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEK 756
Score = 63.3 bits (147), Expect = 9e-09
Identities = 152/745 (20%), Positives = 309/745 (41%), Gaps = 87/745 (11%)
Query: 418 SSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKE 477
SS + E+ Q + L +++ E+K + ++ E + + + + ++RE ++ E
Sbjct: 11 SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERDGENDSLKDKVENLERELQMSE 70
Query: 478 LEQEV----ARSTEVALR-LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ 532
QE+ A +++ + L+ ++ E L+ + + E +++ + G
Sbjct: 71 ENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTL-RSEKENLTKQIQEKQGQL 129
Query: 533 EDPAQLLRDLQDSLER----EADLREQLRNAEEETAN-CKQVNPPTFL---DKQVM--TD 582
+ +LL + LE E ++E+ + A E N K++N D+++M T+
Sbjct: 130 SELDKLLSSFKSQLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATE 189
Query: 583 NIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIF 642
+ I E + NSI+ + E + L + + +E++ H DL +
Sbjct: 190 QSLDPPIEEEHQLRNSIE-------KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVE 242
Query: 643 N-----HMAANNLRKTAARVEEDN---ESLLLQLKKMATKARSRKLS-PTPPANKLSIET 693
N +A N A E E+L +++ M R +L T + K +
Sbjct: 243 NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTN 302
Query: 694 ANDNDEKETDEAD--PAEMKLLLELNEQEATVLRRKVE-ELEQDKEALKKQVKE-----L 745
+++ E + + + +L+ EQE ++ K +E + LK ++E +
Sbjct: 303 ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQPCIM 362
Query: 746 TSKISSVTKTSAGSNTTA----RRSL------TTNSNKLAEERVKVLEDEIDEVRKKLIE 795
T K S + + S + L N+ + + V L E+++ ++KL +
Sbjct: 363 TKKPVSAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 422
Query: 796 KERDCERLHAELSLAQKKPKTLIKSRSLDASDQ----QNVDLKRQLQVIEQEASVLRAKT 851
K+ + RL ++ Q + + + K ++ Q QN++L+ +EQ+ VL++K
Sbjct: 423 KDEEISRLKNQI---QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKN 479
Query: 852 QSLEADNEKLQTENK----KLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
SL+ E LQ+ K +L+L K K +K ++ T K T+L+ E+ E K EL
Sbjct: 480 ASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK-VNKMTAKETELQREMHEMAQKTAEL 538
Query: 908 EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDD 967
Q+E S +K R + + +KS + KD
Sbjct: 539 ----QEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMH------KDQ 588
Query: 968 AQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
+K K R ++ + +L + +K + L + + Y V +++T+K +
Sbjct: 589 VEKEGKVR--EEIAEYQLRLHEAEKKHQALLLDTNKQYEV--EIQTYREKLTSKEECLSS 644
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN---- 1082
++ L K+ E N + T+I L+++ K + D + N+ K ENE +
Sbjct: 645 -QKLEIDLLKSSKEELNNSLKATTQI--LEELK-KTKMDNLKYVNQLKK-ENERAQGKMK 699
Query: 1083 -LSNQCKTLTEEMKNREAQINKLSA 1106
L CK L EE + + ++++L A
Sbjct: 700 LLIKSCKQLEEEKEILQKELSQLQA 724
Score = 54.0 bits (124), Expect = 5e-06
Identities = 110/587 (18%), Positives = 240/587 (40%), Gaps = 52/587 (8%)
Query: 116 LGADGSDSNAVTVNLKLPKRRLTGPLPDLDTGQTTNGSQTQLAITKNDSLAERVRKMQLL 175
L A+ S T+ K+ +T L L+ T S+ + + ER+ +++++
Sbjct: 260 LEAENSKGEVETLKAKI--EGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEII 317
Query: 176 KTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKN-SRNSTNL 234
+ SFE EKE+E+ + + +SS ++ +M K S NL
Sbjct: 318 NS--SFENILQ-EKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQPCIMTKKPVSAKEQNL 374
Query: 235 KPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEK 294
V ++ S+V ++E KQ+++ + R++ +
Sbjct: 375 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 434
Query: 295 SDI--LLRRLANIDTANKYTTGRSSEV----LKLQQKVNELTTHNEDLRDEKKHLTQKIR 348
D L+ +L+ ++ ++ ++ E+ ++L+QK+ L + N L+D + L +
Sbjct: 435 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 494
Query: 349 EIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDN 408
+E+ELE T+ + K+ A ET EL E +M ++ +L ++
Sbjct: 495 NLENELEL---TKMDKMSFVEKVNKMTAKET---ELQREMHEMAQKTAELQEELSGEKNR 548
Query: 409 FREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDG 468
A E L E++ + + L+ + + ++ D + +++ E E K+ E +
Sbjct: 549 L----AGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIA---- 600
Query: 469 MQRENRIKELEQE-VARSTEVALRLQRELAEANSKFTGSNPSLMKVP-QPETVKVSRSSL 526
+ + R+ E E++ A + + + E+ K T L + + +K S+ L
Sbjct: 601 -EYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEEL 659
Query: 527 TRGGSQEDPAQLLRDLQ----DSLEREADLREQLRNAEEE----TANCKQVNPPTFLDKQ 578
S + Q+L +L+ D+L+ L+++ A+ + +CKQ+ +K+
Sbjct: 660 --NNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE----EKE 713
Query: 579 VMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPY 638
++ + + + T ++ + + +T + K ++++ T+E + D Y
Sbjct: 714 ILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKE-----TLEEKTKEADEYLD-KY 767
Query: 639 LSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPP 685
S+ ++ L K +E L Q K ++ S L P P
Sbjct: 768 CSLL--ISHEKLEKAKEMLETQVAHLCSQQSKQDSRG-SPLLGPVVP 811
Score = 43.2 bits (97), Expect = 0.010
Identities = 132/757 (17%), Positives = 283/757 (37%), Gaps = 55/757 (7%)
Query: 1020 KTKLEKEIDEIRS-KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALEN 1078
K ++ E DE + +++ E E + L+ ++ L+ E ++++ + +
Sbjct: 26 KLRVRIEADEKKQLHIAEKLKERDGENDSLKDKVENLERELQMSEENQELVILDAENSKA 85
Query: 1079 ENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
E L Q + + +K E + L ++ +N T +
Sbjct: 86 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSQLEE 145
Query: 1139 XXXXXXQV--DNYTKIDQDKNKLLKEVGDKTKKI-GDXXXXXXXXXXXCKRIEKQLSTRK 1195
Q+ ++ T ++ +N+L KE+ + + GD IE++ R
Sbjct: 146 KEQAEIQIKEESKTAVEMLQNQL-KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 204
Query: 1196 DRVTXXXXXXXXXXXQAVVLA----NTHRRLSIELTSEKDELQARFIKTESKFITLEAEM 1251
Q VL + H ++ E E + +T + LEAE
Sbjct: 205 SIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN 264
Query: 1252 RDLKAD-YENKITSLESTIAAKDVHIKQLEDALRQTTND--KYDEATSPVEMVEMRXXXX 1308
+ + + KI + ++ ++ + + TN+ K E S +E++
Sbjct: 265 SKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEDLTNELQKEQERISELEIINSSFENI 324
Query: 1309 XXXXXXXXXQ-DELNNAKIKLEKTEAESSAAKLEMAQL-KSDLAKLENXXXXXXXXXXXX 1366
Q E ++ +++ +T+ +SS + + + K ++ E
Sbjct: 325 LQEKEQEKVQMKEKSSTAMEMLQTQLKSSMREWQPCIMTKKPVSAKEQNLSSQVECLELE 384
Query: 1367 XXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG 1426
++AK LQS L + + ++ KD E++ LK +++ EQ
Sbjct: 385 KAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ----- 439
Query: 1427 AKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGE 1486
+++L Q E E +L L E L K ++L+ ++ + T+E Q+ +
Sbjct: 440 --LVSKLSQVEGEHQLWKEQNLELRNLTVE-LEQKIQVLQSKNASLQD--TLEVLQSSYK 494
Query: 1487 LLHVQKELSTALGEIKTLQE--KLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERAR 1544
L + EL T + ++ +++ K+ + E EM A LQE L G E+ R
Sbjct: 495 NLENELEL-TKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSG-----EKNR 548
Query: 1545 LNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXX 1604
L L E++++ D+ + E + E+ K++
Sbjct: 549 LAGELQLLLEEIKSSKDQ--LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLR- 605
Query: 1605 XXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHN-------QVSRFRRE 1657
+ ++EK +A + DT +YE ++ T R++L S ++ +
Sbjct: 606 ----------LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSS 655
Query: 1658 RDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCE 1717
++ L+A + + E+K + N + + E + K+ LL + LE+E
Sbjct: 656 KEELNNSLKATTQILEELKKTKMDNLKYVNQLKK-ENERAQGKMKLLIKSCKQLEEEKEI 714
Query: 1718 SRLLASKLNTELVSEKSSA--EVRLAEMQSRLNEYEE 1752
+ S+L +K+ + ++ E+ + + E +E
Sbjct: 715 LQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKE 751
>AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring protein
AKAP350 protein.
Length = 3595
Score = 80.2 bits (189), Expect = 7e-14
Identities = 182/874 (20%), Positives = 363/874 (41%), Gaps = 87/874 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
DEK E E +++ EQE +++ELE +++ ++++ +EL S+ K A
Sbjct: 1617 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLSRQKEAMKAEA 1675
Query: 758 GSNTTARRSLTTNSNKLAEERVKV---LEDEIDEVRKKLIEKERDCE-RLHAELSLAQKK 813
G + L + KL +E+++V E + D+++K++ E D E ++ + L Q+K
Sbjct: 1676 GP---VEQQLLQETEKLMKEKLEVQCQAEKDRDDLQKQVKALEIDVEEQVSRFIELEQEK 1732
Query: 814 PKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLK 872
L+ R QQN L++QL E+ L + E + + Q E +KL Q LK
Sbjct: 1733 NTELMDLR------QQNQALEKQL---EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 1783
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
R + T++ QL N LKE K EL + + + + + R E K E
Sbjct: 1784 VVP--RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 1841
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTT-KLQLK 990
+ +Q L + Q ++ + I +K ++T + QL+
Sbjct: 1842 RELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 1901
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKE-------IDEIRSKLSKNDSEFT 1042
+ E+LE + E+ + + KE T + + LE+E ++++ + ++D+ T
Sbjct: 1902 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 1961
Query: 1043 NEKNRL-----------QTEIAKLKDVNAKLEGDKDVFANKYKALENENS---NLSNQCK 1088
+++ L + EI +L + KL+ + + K +E +N +L Q +
Sbjct: 1962 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN-KVIEEKNELIRDLETQIE 2020
Query: 1089 TLTEEM----KNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
L + +NRE +I +L+ ++ LQ +++
Sbjct: 2021 CLMSDQECVKRNREEEIEQLNEVIEK---LQQELANI---GQKTSMNAHSLSEEADSLKH 2074
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQL-STRKDRVTXXXX 1203
Q+D + +K L ++V +++ ++ ++L S +++R +
Sbjct: 2075 QLD---VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKI 2131
Query: 1204 XXXXXXXQAVVLANTHR-RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKI 1262
V + + + + +E+ +D L++ ++ ++ F + E + + E ++
Sbjct: 2132 QSIPENSVNVAIDHLSKDKPELEVVLTEDALKS--LENQTYFKSFEENGKGSIINLETRL 2189
Query: 1263 TSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQDEL 1321
LEST++AKD+ + Q ++ +++ ++V ++ Q +L
Sbjct: 2190 LQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL 2249
Query: 1322 NNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELD 1381
+ + + + + +L +L S E++ E+
Sbjct: 2250 EAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI--SELESQVVEMH 2307
Query: 1382 TDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
T L E+++++ IA +K+V K+ +L L+ L+ E+ K+ + E +T
Sbjct: 2308 TSLILEKEQVE---IA-EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTT 2363
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQA---QGELL-------HVQ 1491
+L HS E + EL E L E V TKA L KE+A Q ELL +Q
Sbjct: 2364 TELFHSNE-ESGFFNEL----EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQ 2418
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
K+LS + +EKL S ++TE+Q S
Sbjct: 2419 KDLSQVRDHLAEAKEKL---SILEKEDETEVQES 2449
Score = 58.8 bits (136), Expect = 2e-07
Identities = 127/669 (18%), Positives = 273/669 (40%), Gaps = 58/669 (8%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKI 347
++VE + + + I+ N + L+L+ K LTT ++ L + ++ + QK
Sbjct: 4 KKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK---LTTADKLLGELQEQIVQKN 60
Query: 348 REIES-ELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQ 406
+EI++ +LE S + + + E+++ + E L + +++ ++ +
Sbjct: 61 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKL 120
Query: 407 DNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKA-------EHEKKL 459
+ R + + Y +++Q + + + KT K + ++ E + KL
Sbjct: 121 EQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL 180
Query: 460 LEIVGGPDG--MQRENRIKE-LEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP 516
+ + +Q N KE L++E+ E LQR+L + + + S + + Q
Sbjct: 181 MNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ- 239
Query: 517 ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR-NAEEETANCKQVNPPTFL 575
T+ S L + DL+ + ++ R++L E E N K
Sbjct: 240 -TIAEQESKLNEAHKS---LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEK 295
Query: 576 DKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD---SPPLSIDKTTEETQF 632
+K + D + E ++ +++ + SK K D ++I+K +
Sbjct: 296 EKNAVLDRMA----ESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 351
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
H+ + N M+ + + E+DN + TK +++ + L
Sbjct: 352 HYKQQIDGLQNEMSQ---KIETMQFEKDN---------LITK-QNQLILEISKLKDLQQS 398
Query: 693 TANDNDEKETDEADPAEMKL-LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS 751
N E+ T + + + ++ +L E+E L ++V+EL+ E L+KQ+KE + +
Sbjct: 399 LVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 458
Query: 752 VTKTSAGSNTTARRSLTTNSNKL-------AEERVKVLEDEIDEVRKKLIEKERDCERLH 804
N+ + T + L EER+ L+ + + + EKE + +
Sbjct: 459 KFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI-LIE 517
Query: 805 AELSLAQ---KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
L Q + + + K R+ + ++N ++ Q ++ E+ A +L+ K LE K
Sbjct: 518 ENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-ELQEEYACLLKVK-DDLEDSKNKQ 575
Query: 862 QTENK-KLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKV 920
+ E K KL+ L + L + K + + +E K +A+ E+ + + + +E
Sbjct: 576 ELEYKSKLKALN--EELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELME 633
Query: 921 RFTEATKKE 929
+ E TK+E
Sbjct: 634 KL-EVTKRE 641
Score = 55.2 bits (127), Expect = 2e-06
Identities = 167/873 (19%), Positives = 339/873 (38%), Gaps = 77/873 (8%)
Query: 290 VEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIRE 349
++ E +++L + + A + SE Q + T E +R+ + +
Sbjct: 1523 IDPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATES 1580
Query: 350 IESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNF 409
++ + E R ++R EQL +L AE + + DE ++++++ ++
Sbjct: 1581 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1640
Query: 410 REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ------EKAEHEKKLLEIV 463
++ L E +Q + +LS + + + +A +EQ EK EK ++
Sbjct: 1641 L-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 1699
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
D + ++K LE +V + L++E N +L K + +
Sbjct: 1700 AEKDRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 1759
Query: 524 SSLTRGGSQEDPAQLLRDLQDSL----------EREADLREQLRN-AEEETANCKQVNPP 572
++ R ++ Q ++ L+ L E + EQL N +E+T C ++
Sbjct: 1760 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL--- 1816
Query: 573 TFLDKQVMTDNIV--TCDIHESETVTNSIQNKMIHAASTPSSKEK-------SDSPPLSI 623
L K+ + +I +I + E ++ ++ +A T E P LS+
Sbjct: 1817 -LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSL 1875
Query: 624 DKTTEETQFHFDLPYLSIFN-HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + + D I N R+ E+ + L +QL ++ K + +L
Sbjct: 1876 EVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL-EIQKKESTTRLQE 1934
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
NKL K+ E +K ++ Q+ VL K ++ Q+KE Q+
Sbjct: 1935 LEQENKLF---------KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQL 1985
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCER 802
E +K+ K + + ++ E +++ L + + V++ +E + E+
Sbjct: 1986 NEQVTKLQQQLKITTDNKVIEEKNELIRD---LETQIECLMSDQECVKR---NREEEIEQ 2039
Query: 803 LHAELSLAQKKPKTLIKSRSLDA-SDQQNVD-LKRQLQVIEQEASVLRAKTQSLEAD--- 857
L+ + Q++ + + S++A S + D LK QL V+ E L + ++ +
Sbjct: 2040 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2099
Query: 858 --NEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL-ENELKEA---LAKIK-ELEMI 910
N +T K QL + SL+ ++ + +K + EN + A L+K K ELE++
Sbjct: 2100 MKNVLKETNFKMNQLTQELFSLKRERE---SVEKIQSIPENSVNVAIDHLSKDKPELEVV 2156
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD-DAQ 969
++ + T E + S K +KD Q
Sbjct: 2157 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2216
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK---- 1025
F+ + +K K+ +K+ L +I ++ V + A T ++ E+
Sbjct: 2217 GQFETEMLQKKIVNLQKIVEEKVAAALVSQI-QLEAVQEYAKFCQDNQTISSEPERTNIQ 2275
Query: 1026 EIDEIR-SKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
++++R +L + S T + L++++ ++ + LE ++ A K LE E L
Sbjct: 2276 NLNQLREDELGSDISALTLRISELESQVVEM-HTSLILEKEQVEIAEK-NVLEKEKKLLE 2333
Query: 1085 NQCKTLTEEMKNREAQINKLSAD---LKNATSL 1114
Q E K RE + + D LK T L
Sbjct: 2334 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL 2366
Score = 52.8 bits (121), Expect = 1e-05
Identities = 84/413 (20%), Positives = 167/413 (40%), Gaps = 32/413 (7%)
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTS-KISSVTKTSAGSNTTARRSLTT 769
KLL ++E + + KV + E +E+ +++ + S K + + AR L
Sbjct: 1544 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1603
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
+K AE + DE +++ EK +RL EL A + + L ++QQ
Sbjct: 1604 ELSK-AEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL-------EAEQQ 1655
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ +R+L ++EA ++A+ +E ++L E +KL K +++K D K+
Sbjct: 1656 QIQEERELLSRQKEA--MKAEAGPVE---QQLLQETEKLMKEKLEVQCQAEKDRDDLQKQ 1710
Query: 890 TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXX 949
LE +++E +++ ELE EK + ++ K +
Sbjct: 1711 VKALEIDVEEQVSRFIELEQ-------EKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 1763
Query: 950 XXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMK 1008
Q ++ L+ Q PR T ++ QL +++ + E+ + +
Sbjct: 1764 REHERDVFQQEIQKLEQ--QLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 1821
Query: 1009 NAGLSGKEMTAKT-KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK---DVNAKLEG 1064
+E + KLE + E+ L + F ++R + K + +L+
Sbjct: 1822 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQA 1881
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
++D K E E +NL Q + EE++N+ ++ +L L+ TT
Sbjct: 1882 ERDAIDRK----EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 1930
Score = 51.2 bits (117), Expect = 4e-05
Identities = 133/710 (18%), Positives = 295/710 (41%), Gaps = 66/710 (9%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
+ Q Q++ L+ +V+ R +E+EK+ L+ + ++ K+++ ++
Sbjct: 1706 DLQKQVKALEIDVEEQVSRFIELEQEKNTELM-------DLRQQNQALEKQLEKMRKFLD 1758
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELET----RPSTEAQTRQIEQLRAKLLAAETLCEE 383
E E RD Q+I+++E +L+ +P +E QTR++EQL L C E
Sbjct: 1759 EQAIDREHERDV---FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 1815
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
L+ E +++++++ ++ FR + ++ + + Q +++ + K E
Sbjct: 1816 LLLSKEQLQRDIQERNEEIEKLE--FRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 1873
Query: 444 KAD-QLEQEKAEHEKKLLEIVGGPDGMQR-----ENRIKELEQ-----EVARSTEVALRL 492
+ QL+ E+ ++K EI + +++ EN+ +E++Q E+ + E RL
Sbjct: 1874 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK-ESTTRL 1932
Query: 493 QRELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
Q EL + N F L + + + + + + G + + ++ E+
Sbjct: 1933 Q-ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 1991
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQV---MTDNIVTC-----DIHESETVTNSIQNKM 603
L++QL+ + ++ L+ Q+ M+D +I + V +Q ++
Sbjct: 1992 LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQEL 2051
Query: 604 IH-----AASTPSSKEKSDSPPLSIDKT-TEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+ + + S E++DS +D E+ + + N L++T ++
Sbjct: 2052 ANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKM 2111
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKE---TDEA-----DPAE 709
+ + L LK+ + P N + D E E T++A +
Sbjct: 2112 NQLTQE-LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2170
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
K E + L ++ +LE A ++ + +I + + ++ +
Sbjct: 2171 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI-V 2229
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLI-EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
N K+ EE KV + +++ + + E + C+ +++ + +T I++ + D+
Sbjct: 2230 NLQKIVEE--KVAAALVSQIQLEAVQEYAKFCQ---DNQTISSEPERTNIQNLNQLREDE 2284
Query: 829 QNVDLKR-QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
D+ L++ E E+ V+ T SL + E+++ K + L K K L K L+ N
Sbjct: 2285 LGSDISALTLRISELESQVVEMHT-SLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNE 2342
Query: 888 KKTTQLENELKEALAKIKELEMICQ-DEKSEKKVRFTEATKKETDTLKSK 936
KK Q E E K + ++ L+ + +E+ F E +++ +K
Sbjct: 2343 KK--QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2390
Score = 50.8 bits (116), Expect = 5e-05
Identities = 127/686 (18%), Positives = 284/686 (41%), Gaps = 55/686 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ ++++++++E +EV L + E +KE + RL ++ NK ++
Sbjct: 1896 LEEQLEQFREELENKNEEVQQLHMQLEIQKKEST----TRLQELEQENKLFKDDMEKLGL 1951
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
++ + ++T ++ + K Q I+E E E++ Q +++Q + K+ +
Sbjct: 1952 AIKESDAMSTQDQHVLFGK--FAQIIQEKEVEID---QLNEQVTKLQQ-QLKITTDNKVI 2005
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKLKK 440
EE + D++ ++ L ++ N RE++ ++ + + +L+Q + N + S
Sbjct: 2006 EEKNELIRDLETQIECLMSDQECVKRN-REEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2064
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAEA 499
+AD L K + + + E + ++ N + V + T + +L +EL
Sbjct: 2065 LSEEADSL---KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2121
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
+ S + +P+ +V V+ L++ E L D SLE + + N
Sbjct: 2122 KRE-RESVEKIQSIPE-NSVNVAIDHLSK-DKPELEVVLTEDALKSLENQTYFKSFEENG 2178
Query: 560 EEETANCK----QVNPPTFLDKQVMTDNIVTC-DIHE-SETVTNSIQNKMIHAASTPSSK 613
+ N + Q+ +T D+ E + T +Q K+++ K
Sbjct: 2179 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2238
Query: 614 EKSD-SPPLSIDKTTEETQFHFDLPYLSI----FNHMAANNLRKTAARVEEDNESLLLQL 668
+ + ++ E +F D +S N N LR+ + D +L L++
Sbjct: 2239 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED--ELGSDISALTLRI 2296
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
++ ++ S K +E A N ++ E E++ LLE NE +K
Sbjct: 2297 SELESQVVEMHTSLI--LEKEQVEIAEKNVLEK--EKKLLELQKLLEGNE-------KKQ 2345
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
E E+ + +V + T+++ + S N + + K AE + +++ ++
Sbjct: 2346 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK-AE--LASYKEKAEK 2402
Query: 789 VRKKLIEKERDCERLHAELS-----LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
++++L+ KE + L +LS LA+ K K I L+ D+ V ++ + E
Sbjct: 2403 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSI----LEKEDETEVQESKKACMFEPL 2458
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
L S K+ + N+ Q+L ++ + + ++++ T++ ++ E + K
Sbjct: 2459 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 2518
Query: 904 IKELEMICQDEKSEKKVRFTEATKKE 929
++EL + + + TE K+E
Sbjct: 2519 MQELHAAEILDMESRHISETETLKRE 2544
Score = 50.0 bits (114), Expect = 8e-05
Identities = 108/549 (19%), Positives = 227/549 (41%), Gaps = 39/549 (7%)
Query: 576 DKQVMTDNIVTCDIHESETVTNS-IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF-- 632
DK D ++ ++ E N I+N + ++ + +S + T EE Q
Sbjct: 40 DKLTTADKLLG-ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 98
Query: 633 HFDLPY-LSIFNHMAANNLRKTA---ARVEEDNESLLLQLKKMATKARSRKLSPTPPANK 688
H D + I M RK A ++E ++Q+K+ + ++ +K
Sbjct: 99 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 158
Query: 689 LSIETANDNDEKETDEADPAEMKLL----LELNEQEATVLRRKVEE----LEQDKEALKK 740
+E A + T D ++ + L + Q+ + K++E + ++K AL++
Sbjct: 159 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 218
Query: 741 QVKELTSKIS-SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI---DEVRKKLIEK 796
Q+++L ++S S + T A + N + V+ L+ EI E RK+L E
Sbjct: 219 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL-EL 277
Query: 797 ERDCERLHAELSLAQ-KKPKTLIKSRSLDASDQQNVDLKRQLQVI-EQEASVLRAKTQSL 854
+ + E + ++ L +K K + R ++ + + L+ QL E+E S L+ +
Sbjct: 278 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 337
Query: 855 EADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ-----LENELKEALAKIKELEM 909
N + +N + + L+++ + + T + + +N+L ++K+K+L+
Sbjct: 338 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ 397
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
+ KSE+ +KE + L+ ++ + +K ++D Q
Sbjct: 398 SLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQ 457
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
+ F + K L+ M++ E ++ + S K + + EKEI E
Sbjct: 458 EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD---SIKSKSKDSVWEKEI-E 513
Query: 1030 IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKT 1089
I L + + + + +L EI K ++ + E + +V Y+ L+ E + L + K
Sbjct: 514 I---LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLL-KVKD 566
Query: 1090 LTEEMKNRE 1098
E+ KN++
Sbjct: 567 DLEDSKNKQ 575
Score = 50.0 bits (114), Expect = 8e-05
Identities = 128/666 (19%), Positives = 265/666 (39%), Gaps = 57/666 (8%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
E LQ+++ +L R++ + Q I E ES+L +E L+A++++A
Sbjct: 212 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN---EAHKSLSTVEDLKAEIVSA 268
Query: 378 ETLCEELMDENE----DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN-CR 432
+EL ++E + K +L L + D E Q E LR +L + +
Sbjct: 269 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 328
Query: 433 VLSFKLKKTER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
L L+ R ++L+ H K+ ++ + + E E + + + ++ L
Sbjct: 329 KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 388
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPET---VKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
+ + L + S M + E +++ R G+ E Q L+ + LE+
Sbjct: 389 ISK-LKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 447
Query: 549 -----EADLREQLRNAEEETANCKQVNPPTFLDKQVMT-----DNIVTCDIHESETVTNS 598
E DL+E+ E E + K ++ T + ++ D +S++ +S
Sbjct: 448 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKS-KDS 506
Query: 599 IQNKMIHAASTPSSKEKSDSPPLS--IDKTTEETQF---HFDLPYLSIFNHMAANNLRKT 653
+ K I + K L+ I+K F +F++ Y + A L K
Sbjct: 507 VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC--LLKV 564
Query: 654 AARVEEDNESLLLQ----LKKMATKARSRKLSPTPPANKLSIE------TANDNDEKETD 703
+E+ L+ LK + + ++++PT K S+ A + E
Sbjct: 565 KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVV 624
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
E D E+ LE+ ++E L +++ +L + + ++ L ++ S+ + +
Sbjct: 625 EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRC 684
Query: 764 RR-SLTTNSNKL-----AEERVKVLEDEIDEVRKKLIEKE-RDCERLHAELSLAQKKPKT 816
R + N N+ + +V L D + + + E + E S + K
Sbjct: 685 RELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV 744
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLK 872
++ ++ +Q + L + +E+S LRA S L+ + L++E L+L
Sbjct: 745 SFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPSENDKLQKELNVLKSEQNDLRLQM 803
Query: 873 NAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
A+ + + + + +ENE +AL +KE + Q+EK ++ + + E
Sbjct: 804 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL---ELQ 860
Query: 932 TLKSKQ 937
T+K+++
Sbjct: 861 TMKTQE 866
Score = 44.8 bits (101), Expect = 0.003
Identities = 83/473 (17%), Positives = 186/473 (39%), Gaps = 25/473 (5%)
Query: 279 EVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRD 338
E+ L+ + + KS+ + ++ + + E L+Q+V EL E L
Sbjct: 388 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 447
Query: 339 EKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDL 398
+ K ++E ++LE S ++ + K+ + E L+ + K +
Sbjct: 448 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSV 507
Query: 399 XXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKA--EHE 456
+ ED + L E+E K SF K E +L++E A
Sbjct: 508 WEKEIEILIEENEDLKQQCIQLNEEIE---KQRNTFSFAEKNFEVNYQELQEEYACLLKV 564
Query: 457 KKLLEIVGGPDGMQRENRIKELEQE--VARSTEVALRLQRELAEANSKFTGSNPSLMKVP 514
K LE ++ ++++K L +E + R ++++ + + + F + +V
Sbjct: 565 KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVV 624
Query: 515 QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE----ADLREQLRNAEEE----TANC 566
+ +T ++ + + +Q L DL + L+++ + L E++++ ++E + C
Sbjct: 625 EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRC 684
Query: 567 KQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKS---DSPPLSI 623
+++ + +N+ +CD S + + A + S KS +S +
Sbjct: 685 RELE---IIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVE 741
Query: 624 DKTTEE--TQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
DK + E T I +H+ + ++++ R + +E+ LQ + K+ L
Sbjct: 742 DKVSFENMTVGEESKQEQLILDHLPSVT-KESSLRATQPSENDKLQKELNVLKSEQNDLR 800
Query: 682 PTPPANKLSIETANDNDEKETDE-ADPAEMKLLLELNEQEATVLRRKVEELEQ 733
A ++ + + E + + K L L E+ K++EL++
Sbjct: 801 LQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQK 853
Score = 41.9 bits (94), Expect = 0.022
Identities = 146/720 (20%), Positives = 288/720 (40%), Gaps = 86/720 (11%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDE----KKHL 343
ER +EK+DI+ R + A+ +E ++Q++ L+ E ++ E ++ L
Sbjct: 1623 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL 1682
Query: 344 TQKIREIESE-LETRPSTEAQTRQIE-QLRAKLLAAETLCEELMDENEDMKKELRDLXXX 401
Q+ ++ E LE + E ++ Q++A + E ++ ++ EL DL
Sbjct: 1683 LQETEKLMKEKLEVQCQAEKDRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQ 1742
Query: 402 XXXMQDNF-------------REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
++ RE + D + ++LEQ +K + R+ +QL
Sbjct: 1743 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQL 1802
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRE-----NRIKELEQEVARSTEVALRLQRELAE--ANS 501
E K E++ + +QR+ I++LE V R E AL + + + +
Sbjct: 1803 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV-RELEQALLVSADTFQKVEDR 1861
Query: 502 KFTG---SNPSL-MKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
K G + P L ++V Q E + R +E Q +L++ E L QL
Sbjct: 1862 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 1921
Query: 557 R-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI-HAASTPSSKE 614
+E T +++ L K M + I ES+ ++ Q+ + A KE
Sbjct: 1922 EIQKKESTTRLQELEQENKLFKDDMEK--LGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 1979
Query: 615 -KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN------NLRKTAARVEEDNESLLLQ 667
+ D + K ++ + D + N + + L V+ + E + Q
Sbjct: 1980 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2039
Query: 668 LKKMATKARSR--KLSPTPPANKLSIETANDNDEKETDE--ADPAEMKLLLELNEQEATV 723
L ++ K + + N S+ D+ + + D A+ ++ +E +E T
Sbjct: 2040 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2099
Query: 724 LRR-------KVEELEQDKEALKKQVKELTSKISSVTKTSAG-SNTTARRSLTTNSNKLA 775
++ K+ +L Q+ +LK++ +E KI S+ + S + + L
Sbjct: 2100 MKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2158
Query: 776 EERVKVLEDE-------------IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
E+ +K LE++ I + +L++ E EL+ K+ K + +
Sbjct: 2159 EDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 2218
Query: 823 LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA---------DNEKLQTENKKLQLLKN 873
+ Q + Q V E+ A+ L ++ Q LEA DN+ + +E ++ ++N
Sbjct: 2219 FETEMLQKKIVNLQKIVEEKVAAALVSQIQ-LEAVQEYAKFCQDNQTISSEPERTN-IQN 2276
Query: 874 AKSLRSDK-ALDLN--TKKTTQLENELKE---ALAKIKELEMICQDEKSEKKVRFTEATK 927
LR D+ D++ T + ++LE+++ E +L KE I + EK+ + E K
Sbjct: 2277 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK 2336
Score = 41.1 bits (92), Expect = 0.039
Identities = 73/339 (21%), Positives = 145/339 (42%), Gaps = 26/339 (7%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
+ +EL+S KD R + + + + + + +LK++ LE+T+ A+ H+K+LE
Sbjct: 2824 MQVELSSMKD----RATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE- 2878
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
A R DK DE V + + Q L K KL ++E E +LE
Sbjct: 2879 AFRLEVKDKTDE----VHL--LNDTLASEQKKSRELQWALEKEKAKLGRSE-ERDKEELE 2931
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKEL--DTDLQSER-KKLDRMRIAH 1398
+ + K N S + +++ + D L E+ + L+ +
Sbjct: 2932 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLE 2991
Query: 1399 DKDVKNKDAELATLKGKLKI---LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEY 1455
+ V+ ++ +TL + ++ L+ + G G R L E+ +K+L+ L + +
Sbjct: 2992 SEKVRIREMS-STLDRERELHAQLQSSDGTGQSR-PPLPS--EDLLKELQKQLEEKHSRI 3047
Query: 1456 EELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
EL + E + + + T+ ++ ++ Q + L ++E +T G+ K + + E
Sbjct: 3048 VELLNETEKYKLDSLQTRQQMEKDR-QVHRKTLQTEQEANTE-GQKKMHELQSKVEDLQR 3105
Query: 1516 NTEKTEMQNSIASLQ-ERLCGGGWEVERARLNARLDQRE 1553
E+ Q L+ +RL G E ++ L R ++RE
Sbjct: 3106 QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELE-REEKRE 3143
Score = 40.3 bits (90), Expect = 0.069
Identities = 44/202 (21%), Positives = 97/202 (48%), Gaps = 14/202 (6%)
Query: 1374 ENKAKELDTDLQSERKKLDRMR-----IAHDKDVKNKDAELATLKGKLKILEQNSGAGAK 1428
+N EL Q ER+ + ++ + + +KD++ T ++ +EQ + +
Sbjct: 64 KNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET--DIVQRMEQETQRKLE 121
Query: 1429 RI-TELKQEYEETVKKLEHSLALEK-AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGE 1486
++ EL + Y + + +++ L + A+ EE+ +++ E + + + +TV ++Q +
Sbjct: 122 QLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK-- 179
Query: 1487 LLHVQ-KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
L++V EL+ L + + +EKL E EK +Q + L E L +++RAR
Sbjct: 180 LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRAR- 238
Query: 1546 NARLDQRERELRAANDRRDVLE 1567
+ ++E +L A+ +E
Sbjct: 239 -QTIAEQESKLNEAHKSLSTVE 259
Score = 39.9 bits (89), Expect = 0.091
Identities = 71/314 (22%), Positives = 144/314 (45%), Gaps = 27/314 (8%)
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD 703
H N + T R +E + L+ + +S+ L + + ++ ++
Sbjct: 2786 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 2845
Query: 704 EADPAEMKLLLELNEQEA-TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ AE+K L + E T L+ + + L++ EA + +VK+ T ++ + T A
Sbjct: 2846 KMVVAELKSELAQTKLELETTLKAQHKHLKE-LEAFRLEVKDKTDEVHLLNDTLASEQKK 2904
Query: 763 ARR---SLTTNSNKL--AEERVKVLEDEIDEVRKKL-IEKERDCE---RLHAELSLAQKK 813
+R +L KL +EER K +E+++++ L +K+R+ + L + L +
Sbjct: 2905 SRELQWALEKEKAKLGRSEERDK---EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 2961
Query: 814 PKTLIKSRSL-DA--SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE---KLQTENKK 867
+ + R L DA S++Q +L+ Q+ ++E E +R + +L+ + E +LQ+ +
Sbjct: 2962 QQKIESQRMLYDAQLSEEQGRNLELQV-LLESEKVRIREMSSTLDRERELHAQLQSSDGT 3020
Query: 868 LQL---LKNAKSLRS-DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
Q L + L+ K L+ + +L NE ++ K+ L+ Q EK + R T
Sbjct: 3021 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKT 3078
Query: 924 EATKKETDTLKSKQ 937
T++E +T K+
Sbjct: 3079 LQTEQEANTEGQKK 3092
Score = 39.5 bits (88), Expect = 0.12
Identities = 56/254 (22%), Positives = 114/254 (44%), Gaps = 24/254 (9%)
Query: 1260 NKITSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
++I +L + + + + +K+ +++ + + +Y+ +M+EM+ Q
Sbjct: 2780 SEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 2839
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSD---LAKLENXXXXXXXXXXXXXXXS---S 1371
++L++ K+ + + ++E + KLE+ LK+ L +LE + +
Sbjct: 2840 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 2899
Query: 1372 YWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRIT 1431
+ K++EL L+ E+ KL R DK+ EL LK L+ +Q + +
Sbjct: 2900 SEQKKSRELQWALEKEKAKLGRSE-ERDKE------ELEDLKFSLESQKQRNLQLNLLLE 2952
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGK----YELLEEEHV-VTKARLTVEKEQAQGE 1486
+ KQ E+ +K+E L A+ E G+ LLE E V + + T+++E+
Sbjct: 2953 QQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERE--- 3009
Query: 1487 LLHVQKELSTALGE 1500
LH Q + S G+
Sbjct: 3010 -LHAQLQSSDGTGQ 3022
Score = 39.1 bits (87), Expect = 0.16
Identities = 51/203 (25%), Positives = 95/203 (46%), Gaps = 21/203 (10%)
Query: 1617 QSEKARK--AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMA- 1673
Q EK ++ I + K + Q+ + +EL Q+ R R+ + L A KS++
Sbjct: 198 QKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST 257
Query: 1674 --EIKNGDKSARIHRNSISSTDEEE---YRNKVALLEQQVACLEDELCESR-LLASKLNT 1727
++K SA R + E E Y+ K+ +LE++ + D + ES+ +L T
Sbjct: 258 VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRT 317
Query: 1728 ELV---SEKSSAEVRLAEMQSRLN-EYEEERLLSSGRARVAGLATRME-----LAWHKER 1778
+L+ E+ S E++ R+N E ++ L + ++ GL M + + K+
Sbjct: 318 QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDN 377
Query: 1779 --DEQQRLLQETSTLARDLRQTL 1799
+Q +L+ E S L +DL+Q+L
Sbjct: 378 LITKQNQLILEISKL-KDLQQSL 399
Score = 36.7 bits (81), Expect = 0.84
Identities = 70/405 (17%), Positives = 166/405 (40%), Gaps = 23/405 (5%)
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSA---GSNTTARRSLTTNSNKLAEERVKVLEDEI 786
EL+ E+ K +++E++S + + A S+ T + S L +E K LE++
Sbjct: 2985 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKH 3044
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+ + L E E+ +L + + Q + + ++L + N + ++++ ++ +
Sbjct: 3045 SRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3102
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L+ + + KL E ++LQ + ++ + +L ++ + L + L +
Sbjct: 3103 LQRQLEEKRQQVYKLDLEGQRLQGI-----MQEFQKQELEREEKRESRRILYQNLNEPTT 3157
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
+ ++ + E KE++ K + Q L+
Sbjct: 3158 WSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKL-QCVASKLQV 3216
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
QK+ + R+ + D + +++ ++++ ++ ++ T+ L +
Sbjct: 3217 LPQKASE-RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTER 3275
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALE-- 1077
+ ++L+ + S+ T EKN L+ + KL++ A + N +E
Sbjct: 3276 LLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAI 3335
Query: 1078 --NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+E + + TL + +K EA++ KL A+L+N + LQT D
Sbjct: 3336 IASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 3380
Score = 33.9 bits (74), Expect = 6.0
Identities = 42/227 (18%), Positives = 98/227 (43%), Gaps = 20/227 (8%)
Query: 348 REIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQD 407
RE ESE +PS E I+Q ++++L + + D +++++L ++
Sbjct: 2798 REQESE---KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKS 2854
Query: 408 NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPD 467
+ + + ++L+ + + +K ++K + L A +KK E+ +
Sbjct: 2855 ELAQTKLELETTLKAQ-HKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALE 2913
Query: 468 GMQRE-NRIKELEQEVARSTEVALRLQRE-------LAEANSKFTGSNPSLMKVPQPETV 519
+ + R +E ++E + +L Q++ L E + N S K+ +
Sbjct: 2914 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL--NESQQKIESQRML 2971
Query: 520 KVSRSSLTRGGSQEDPAQL------LRDLQDSLEREADLREQLRNAE 560
++ S +G + E L +R++ +L+RE +L QL++++
Sbjct: 2972 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSD 3018
>AF049105-1|AAC07988.1| 2442|Homo sapiens centrosomal Nek2-associated
protein 1 protein.
Length = 2442
Score = 80.2 bits (189), Expect = 7e-14
Identities = 158/861 (18%), Positives = 354/861 (41%), Gaps = 55/861 (6%)
Query: 267 KEYQDQIEGLKQEVDILR-KRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
++Y+ I+ L++ V+IL E +E E S L R A + + + + +++
Sbjct: 300 EDYEKMIKALRETVEILETNHTELMEHEAS---LSRNAQEEKLSLQQVIKDITQVMVEEG 356
Query: 326 VN--ELTTHNEDLRDEKKHLTQ-KIREIESELETRPSTEAQTRQ-IEQLRAKLLAAETLC 381
N + + H L + +Q ++ + L S + RQ ++ LR +L +
Sbjct: 357 DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV 416
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
L +++ ++E + L + R+ A + L+ E++ K +L ++
Sbjct: 417 NLLQQQHDQWEEEGKALRQRLQKLTGE-RDTLAGQTVDLQGEVDSLSKERELLQKAREEL 475
Query: 442 ERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEA 499
++ + LEQE + L++ G Q+E++ +EL V R E RLQ L
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEDQQEELHLAV-RERE---RLQEMLMGL 531
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE---READLREQL 556
+K + S L+ + + L R E A L R Q E E L+ ++
Sbjct: 532 EAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEV 591
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKS 616
+ +N LDK + ++ + E S+ ++M A ++ +
Sbjct: 592 ADLRAAAVKLSALNEALALDKVGLNQQLL-----QLEEENQSVCSRMEAAEQARNALQVD 646
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
+ + E H + A L+ ++E+ E +++K +++R
Sbjct: 647 LAEAEKRREALWEKNTHLEAQLQKA--EEAGAELQADLRDIQEEKE----EIQKKLSESR 700
Query: 677 SRKLSPTPPANKLSIETANDND-------EKETDEADPAEMKLLLELNEQEATVLRRKVE 729
++ + T +L E + EKE + A +++ L+ E++ L +++
Sbjct: 701 HQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ 760
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
L KE L+ + E + +SV + + G +++T + ++ + V+ L+ E+D
Sbjct: 761 GLSSAKELLESSLFEAQQQ-NSVIEVTKGQLEVQIQTVT-QAKEVIQGEVRCLKLELDTE 818
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
R + E+ERD +L+ A+++ KT ++ + A+ ++ V+ R+ E+E S +
Sbjct: 819 RSQA-EQERDAAA--RQLAQAEQEGKTALEQQK--AAHEKEVNQLREKW--EKERSWHQQ 871
Query: 850 K-TQSLEA-DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
+ ++LE+ + EK++ E + + +++++ + + ++ + +L+ ++ L
Sbjct: 872 ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLL 931
Query: 908 EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDD 967
E + Q +K +A+++ + + Q LK
Sbjct: 932 ETLLQTQKE-----LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ 986
Query: 968 AQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEI 1027
+ + + L K+ L+K VEDL+ ++ + L +E+ K + +E
Sbjct: 987 HRDDLAALQEESSSLLQDKMDLQKQVEDLK---SQLVAQDDSQRLVEQEVQEKLRETQEY 1043
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC 1087
+ I+ +L + + T + + L++ ++ + + + + E LS Q
Sbjct: 1044 NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103
Query: 1088 KTLTEEMKNREAQINKLSADL 1108
+ L +E+K +EA A L
Sbjct: 1104 ELLRQEVKEKEADFLAQEAQL 1124
Score = 80.2 bits (189), Expect = 7e-14
Identities = 238/1355 (17%), Positives = 540/1355 (39%), Gaps = 89/1355 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
V+ + ++ +Q++GL ++L +++ S I + + ++ + T ++ EV++
Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK-GQLEVQIQTVT-QAKEVIQ 805
Query: 322 LQQKVN--ELTTHNEDLRDEKKHLTQKIREIESELETRPSTE--AQTRQIEQLRAKLLAA 377
+ + EL T E+ +++ + E E +T + A +++ QLR K
Sbjct: 806 GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWE-- 863
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSF 436
+E +++ K L L ++ +E Q + E +RE E+T +
Sbjct: 864 ----KERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL-EQEVARSTEVALR-LQR 494
+L+ TE++ L + + +K+L + + ++++ ++++L EQE + L+ QR
Sbjct: 920 QLE-TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED-PAQLLRDLQDSLER--EAD 551
EL EA + +L Q E+ + + + ED +QL+ QD +R E +
Sbjct: 979 ELKEAARQHRDDLAAL----QEESSSLLQDKMDLQKQVEDLKSQLVA--QDDSQRLVEQE 1032
Query: 552 LREQLRNAEEETANCKQVN-PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
++E+LR +E K++ L +M + E++++ + +
Sbjct: 1033 VQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEA 1092
Query: 611 SSKEKSDSPPLSI-DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE---EDNESLLL 666
++K S + + + +E + F + + A+++ + R ++ ++ L
Sbjct: 1093 QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL 1152
Query: 667 QLKKMATKARSRKLSPTP-PANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
QL+ +T+++ L+ P N+ + + +A + + EL+ +
Sbjct: 1153 QLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA-- 1210
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
V LE D+ + L + +T SA + +A L + K + R VL D+
Sbjct: 1211 PSVWGLEPDQNG----ARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTR-DVLRDQ 1265
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ ++ ++L + E + ++H EL Q++ + +S +QN L+ +L + + +
Sbjct: 1266 VQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS-KWEGKQN-SLESELMELHETMA 1323
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD--KALDLNTKKTTQLENELKEALAK 903
L+++ + E + Q E + LQ K + + + +A + + L+E L
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT 1383
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
+ + +E ++ R +A +++ + LK Q + +++
Sbjct: 1384 ARSALKLKNEEVESERER-AQALQEQGE-LKVAQ--GKALQENLALLTQTLAEREEEVET 1439
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
L+ Q+ K R +K L LKK ++++ + ++ + K + A +
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
E+++ R ++ + + + ++N L+ ++ +L+ + +E + + + L+ + L
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR----GQVQDLKKQLVTL 1555
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
L E E Q KL +L+ Q +
Sbjct: 1556 ECLALELEENHHKMECQ-QKLIKELEGQRETQRV---ALTHLTLDLEERSQELQAQSSQI 1611
Query: 1144 XQVDNY-TKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV---- 1198
++++ T + ++ + +EV + ++I + +R +++L +K+R+
Sbjct: 1612 HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + R ELT+++ +Q R + + + +K
Sbjct: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 1259 ENKITSLESTIAAKDVH-IKQLEDALRQT---TNDKYDEATSPVEMVEMRXXXXXXXXXX 1314
+K +E + +H +++L+D L Q + K E + + E
Sbjct: 1732 RDKEKEVE--CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 1315 XXXQDELNNAKIKLEKTEAESSAA----KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXS 1370
Q EL ++ + EA+ + A +LE Q + A+ +
Sbjct: 1790 AREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQ 1849
Query: 1371 SYWENKAKELD-TDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
++ K + + D + + ++L+ + V+ + L L+ + + E+ A ++
Sbjct: 1850 AHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQ 1909
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEE-----HVVTKARLTVEKEQ-- 1482
E QE+E + L+ S +A +E + E L E H AR E Q
Sbjct: 1910 CAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEA 1969
Query: 1483 -------AQGELLHV--QKELSTAL-GEIKTLQEKLGTESAAWNTEKTEMQNSIASLQER 1532
QG+ H+ Q ELS +L TLQ L A + ++ +Q++
Sbjct: 1970 LGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQ 2029
Query: 1533 LCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
++ + +L L QR+ ELR +R +LE
Sbjct: 2030 --DLRYQEDVQQLQQALAQRDEELRHQQEREQLLE 2062
Score = 63.3 bits (147), Expect = 9e-09
Identities = 93/450 (20%), Positives = 194/450 (43%), Gaps = 22/450 (4%)
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVL 724
LLQL++ SR + N L ++ A +E ++ L+ E+ L
Sbjct: 619 LLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAEL 678
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLED 784
+ + +++++KE ++K++ E + + T + A+R + + E+ V E
Sbjct: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK 738
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
EVR + +E++R + L AE K L++S SL + QQN VIE
Sbjct: 739 AALEVRLQAVERDR--QDL-AEQLQGLSSAKELLES-SLFEAQQQN-------SVIEVTK 787
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
L + Q++ E +Q E + L+L + + ++++ D ++ Q E E K AL +
Sbjct: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847
Query: 905 K---ELEMICQDEKSEKKVRF-TEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
K E E+ EK EK+ + + K ++L+ ++ +
Sbjct: 848 KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE 907
Query: 961 LKSLKDDAQKSFKPRIPKKPTD-LTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTA 1019
++ + A + K+ L T LQ +K + D ++ + MK L +E T
Sbjct: 908 ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTG 967
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
L+ ++ E + +L + + ++ LQ E + L + K++ K V K + + +
Sbjct: 968 --ILQTQLQEAQRELKEAARQHRDDLAALQEESSSL--LQDKMDLQKQVEDLKSQLVAQD 1023
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+S + + + E+++ + + N++ +L+
Sbjct: 1024 DSQRLVE-QEVQEKLRETQ-EYNRIQKELE 1051
Score = 63.3 bits (147), Expect = 9e-09
Identities = 139/689 (20%), Positives = 293/689 (42%), Gaps = 72/689 (10%)
Query: 277 KQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDL 336
++EV+ LR + + +EK++ + A ++ + R+ EV Q+++ EL E
Sbjct: 1434 EEEVETLRGQIQELEKQRE----MQKAALELLSLDLKKRNQEVDLQQEQIQEL----EKC 1485
Query: 337 RDEKKHLTQKIREIESEL--------ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDEN 388
R +HL ++E E +L E E Q +E +L + + E +
Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545
Query: 389 EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
+D+KK+L L +++N + + + L +ELE + RV L ++
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQ--KLIKELEGQRETQRV---ALTHLTLDLEER 1600
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
QE ++ ++ + RE ++E +QEV E LQR+ +
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLARE--LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ 1658
Query: 509 SLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQDSLEREADLREQL--RNAEEETA 564
LM Q E ++V TR +ED Q+ L++ RE + QL AEE
Sbjct: 1659 ELML--QKERIQVLEDQRTRQTKILEEDLEQIKLSLRER-GRELTTQRQLMQERAEEGKG 1715
Query: 565 NCKQVNPPTFLDKQVMTD--NIVTCD---IHESETVTNSIQNKM--IH--AASTPSSKEK 615
K K ++ D V C IHE + + + ++ ++ +H T +
Sbjct: 1716 PSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQ 1775
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
+ + + + +E + +L S+ + + A + D E LQ ++ +
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLD----EAQRALAQRDQELEALQQEQQQAQG 1831
Query: 676 RSRKLSPTPPANKLSIETANDN-DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
+ ++ A + ++E A+ E+ + D E L E+E V R+V+ LE+
Sbjct: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRL---EEELAVEGRRVQALEEV 1888
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L+ + +E + ++ + A + E + L+D + + L
Sbjct: 1889 LGDLRAESREQEKALLALQQQCA------------EQAQEHEVETRALQDSWLQAQAVLK 1936
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRS---LDASDQQNVDLKRQLQVIEQEASV---LR 848
E++++ E L AE S + + + ++R+ +A + + L+ + Q + ++A + L
Sbjct: 1937 ERDQELEALRAE-SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE 1995
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
A T +L+A + Q +++L+ A ++ + D + + ++ +L++ALA+ ++ E
Sbjct: 1996 ASTATLQASLDACQAHSRQLE---EALRIQEGEIQDQDLRYQEDVQ-QLQQALAQ-RDEE 2050
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ Q E+ E+ + + A + + + ++ KQ
Sbjct: 2051 LRHQQER-EQLLEKSLAQRVQENMIQEKQ 2078
Score = 56.0 bits (129), Expect = 1e-06
Identities = 113/579 (19%), Positives = 221/579 (38%), Gaps = 49/579 (8%)
Query: 1213 VVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK 1272
V LA +R L + L+A+ K E L+A++RD++ + E L + +
Sbjct: 645 VDLAEAEKRREA-LWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ 703
Query: 1273 DVHIKQLEDALRQTTNDKYDEATSPVEMVE--MRXXXXXXXXXXXXXQDELNNAKIKLEK 1330
+ QLE L Q + + V+ E +R +D + A+ +L+
Sbjct: 704 EAATTQLEQ-LHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE-QLQG 761
Query: 1331 TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
+ + + + + + +E + + + L +L +ER +
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ 821
Query: 1391 LDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEE--TVKKLEHSL 1448
++ R A + + + E GK LEQ A K + +L++++E+ + + E +
Sbjct: 822 AEQERDAAARQLAQAEQE-----GKTA-LEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
ALE E E++ + L E++ + + E+E+ Q E Q +L T + L+ L
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 1509 GTE----SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
T+ A+ E+ + L+E+ G L +L + +REL+ A
Sbjct: 936 QTQKELADASQQLERLRQDMKVQKLKEQETTG-------ILQTQLQEAQRELKEA----- 983
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
H D D K+ + + E K
Sbjct: 984 -ARQHRDDLAALQEESSSLLQD-----KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037
Query: 1625 EITDTKTRYEGQMNTMRDELK-SLHNQVSRF--RRERDNYKQM-LEAAQKSMAEIKNGDK 1680
T R + ++ + L SL + R +E D+ +Q L A ++ M E + K
Sbjct: 1038 RETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK 1097
Query: 1681 SARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA---E 1737
+ +E + K A Q A L +EL S + +L L ++++ A +
Sbjct: 1098 ELSAQMELL----RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
Query: 1738 VRLAEMQSRLNEYEEERL---LSSGRARVAGLATRMELA 1773
+RL +S+L E+ + +A++A L + ++ A
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Score = 44.8 bits (101), Expect = 0.003
Identities = 119/605 (19%), Positives = 243/605 (40%), Gaps = 50/605 (8%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDL----------KADYENKITSLESTIAAKDVH 1275
L + +L+ R TE++ + E++DL K+ +E K SLES +
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVE-----MRXXXXXXXXXXXXXQDELNNAKIKLEK 1330
+ L+ LR+ + EA E+++ + + + + A I E
Sbjct: 1322 MASLQSRLRRAELQRM-EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 1331 TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
SA KL+ +++S+ E + EN A T L ++
Sbjct: 1381 LRTARSALKLKNEEVESER---ERAQALQEQGELKVAQGKALQENLALLTQT-LAEREEE 1436
Query: 1391 LDRMRIAHDKDVKNKDAELATLKG-KLKILEQNSGAGAKRITELKQEYEETVKKLEH-SL 1448
++ +R + K ++ + A L+ L + ++N ++ E QE E+ LEH +
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ--EQIQELEKCRSVLEHLPM 1494
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKE---LSTALGEIKTLQ 1505
A+++ E ++LT + E + E + K R T ++ + +LL ++K+ + + G+++ L+
Sbjct: 1495 AVQERE-QKLTVQREQIRE---LEKDRET-QRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549
Query: 1506 EKLGT-ESAAWNTEKTEMQNSIASLQERLCGGGWEVERA---RLNARLDQRERELRAAND 1561
++L T E A E+ + + G E +R L L++R +EL+A +
Sbjct: 1550 KQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSS 1609
Query: 1562 RRDVLEHHHDXXXXXXXXXXXXXXDY-ERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEK 1620
+ LE H E++ ++QR E+ +
Sbjct: 1610 QIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV 1669
Query: 1621 ARKAEITDTKTRYEG--QMN-TMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN 1677
TK E Q+ ++R+ + L Q + + K +A + S+ +K
Sbjct: 1670 LEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL 1729
Query: 1678 --GDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSS 1735
DK + + +E +++ LEQQ+ L ++ E+ LL S+ E+V +
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKDQ---LEQQLQGLHRKVGETSLLLSQREQEIVVLQQ- 1785
Query: 1736 AEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERD---EQQRLLQETSTLA 1792
+++ A Q L E + L + +A +E +++ +++R+ ++ L
Sbjct: 1786 -QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQ 1844
Query: 1793 RDLRQ 1797
L Q
Sbjct: 1845 GALEQ 1849
Score = 41.1 bits (92), Expect = 0.039
Identities = 70/331 (21%), Positives = 130/331 (39%), Gaps = 31/331 (9%)
Query: 1250 EMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
E +L E +L++++ A H +QLE+ALR + D+ E V+
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALA 2045
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
Q E LEK+ A+ + M Q K +L +
Sbjct: 2046 QRDEELRHQQEREQL---LEKSLAQ--RVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAK 1428
+ + + + L+ +R L+ + +H ++ + +L +L+ +L+ E A
Sbjct: 2101 LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQ-RELERLQAAL 2159
Query: 1429 RITELKQ-EYEETVKKLEHSLALEKAEYEEL--------------TGKYELLEEEHVVTK 1473
R TE ++ E+ E + L SLA KA L + + L++E +T+
Sbjct: 2160 RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTR 2219
Query: 1474 ARLTVEKEQAQGEL----LHVQKELSTALGEIKTLQEKL---GTESAAWNTEKTEMQNSI 1526
L E+ + G L + E LGE+ ++ + G E +W +Q ++
Sbjct: 2220 RALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAV 2279
Query: 1527 ASLQERLCGGGWEVERARLNARLDQRERELR 1557
A L+ + + +L + L+Q ERE R
Sbjct: 2280 ARLE--IDRSRLQRHNVQLRSTLEQVERERR 2308
Score = 36.3 bits (80), Expect = 1.1
Identities = 41/164 (25%), Positives = 78/164 (47%), Gaps = 16/164 (9%)
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKS-------ARIHRNS 1688
++ T+R+ L+S H + R+E+ L A++S+AE+ + + + R
Sbjct: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600
Query: 1689 ISSTDEEEYRNKVALLEQQVACLEDE---LCESRLLASKLNTELVSEKSSAEVRLAEMQS 1745
+S+ +E +KV L QQ+ LE+E +C A + L + + AE R +
Sbjct: 601 LSALNEALALDKVG-LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659
Query: 1746 RLNEYEEERLLSSGRARVAGLATRMELA-WHKERDEQQRLLQET 1788
+ N + E +L +A AG + +L +E++E Q+ L E+
Sbjct: 660 K-NTHLEAQL---QKAEEAGAELQADLRDIQEEKEEIQKKLSES 699
Score = 35.1 bits (77), Expect = 2.6
Identities = 42/166 (25%), Positives = 76/166 (45%), Gaps = 8/166 (4%)
Query: 1406 DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELL 1465
+ E L+ +L+ L A + +L+ E + K+ E L+KA EEL + E+L
Sbjct: 427 EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERE---LLQKAR-EELRQQLEVL 482
Query: 1466 EEEHVVTK---ARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEM 1522
E+E + L ++ + AQG+ Q+EL A+ E + LQE L A + +E+
Sbjct: 483 EQEAWRLRRVNVELQLQGDSAQGQKEDQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
Query: 1523 QNSIASLQ-ERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+L+ L G E+ + A L + E+ + + + L+
Sbjct: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLK 588
>AB053468-1|BAC54107.1| 992|Homo sapiens ELKS beta protein.
Length = 992
Score = 80.2 bits (189), Expect = 7e-14
Identities = 157/777 (20%), Positives = 337/777 (43%), Gaps = 67/777 (8%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL 374
R + ++ LQ ++ E+ N+ LR + + K+ + ++T S E + + LR
Sbjct: 147 RDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA--LRKDE 204
Query: 375 LAAETLCEE----LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL--EQTI 428
+ T+ +E + +EN+ M+ ++ L +D + Q D S E T
Sbjct: 205 ASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE 264
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEV----- 482
+N + L + ER+A +L + E+ L I + R+ IK+L + +
Sbjct: 265 ENFQRLH---AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 321
Query: 483 -ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
A++TE R LAEA SL++ + E + R + D A+ +
Sbjct: 322 SAKATEEDHERTRRLAEAEMHVHHLE-SLLEQKEKENSMLREEMHRRFENAPDSAKT-KA 379
Query: 542 LQDSLERE----ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LQ +E + + + LR+ EEE K L + + + +++ S +
Sbjct: 380 LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA---LSTEEREEEMKQMEVYRSHS--K 434
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
++NK I S++ ++ L T QF ++ + ++ AA +
Sbjct: 435 FMKNK-IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR-AAIL 492
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELN 717
+ + ++L L+L++ T NK + + + +EK T + ++K +L++
Sbjct: 493 QTEVDALRLRLEEKETML-----------NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 541
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE- 776
E++ VL++K+E L++ +KQ+ L ++ S+ + ++T +LTT LAE
Sbjct: 542 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT----ALTTLEEALAEK 597
Query: 777 ----ERVKVLEDEIDEVRKKLIEK-ERDCERLHAELSLAQ----KKPKTLIKSRSLDASD 827
ER+K D + +++ I+ ++D + L ++SL Q +K +L+ + AS
Sbjct: 598 ERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE-HASS 656
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
+ LK+ ++ E ++ + K + L+ +++ + L+ A SD+ L
Sbjct: 657 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE--ARASPEMSDRIQHLE- 713
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++ T+ ++E +A A++ L I ++ ++EK + + E ++L S+Q
Sbjct: 714 REITRYKDESSKAQAEVDRLLEILKEVENEKNDK--DKKIAELESLTSRQVKDQNKKVAN 771
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK-KMVEDLECEIGE-MYV 1005
++ + ++A++ + + L L+ K +E+LE + E + +
Sbjct: 772 LKHKEQVEKKKSA--QMLEEARRR-EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI 828
Query: 1006 VMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
+ + +E +A+T EK+++E+ + K E + K +L + L + L
Sbjct: 829 TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 885
Score = 58.8 bits (136), Expect = 2e-07
Identities = 146/804 (18%), Positives = 306/804 (38%), Gaps = 63/804 (7%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKT-----LIKSRSLDASDQQNVDL-KR 835
L+ ++ EV ++ +D E ++LS + KT L K R+L + + + K
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK--ALDLNTKKTTQL 893
Q +V+++E ++ Q+L+ ++L+ + QL + S R+ + +L + +L
Sbjct: 214 QYRVVQEENQHMQMTIQALQ---DELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
Query: 894 ----ENELKEA--LAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
E + KE L K ++E+E+ + +K R E+ KK + L+SK
Sbjct: 271 HAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEMLQSKGLSAKATEED 329
Query: 947 XXXXXXXXXXXQAT--LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L+SL + +K + + + + + +
Sbjct: 330 HERTRRLAEAEMHVHHLESLLEQKEKE------NSMLREEMHRRFENAPDSAKTKALQTV 383
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ MK++ +S E + LE+EI ++S + + E E +++ + K + K+
Sbjct: 384 IEMKDSKISSMERGLRD-LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQ 442
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXX 1124
K + K L + L ++ ++ E L+A + A LQT + D +
Sbjct: 443 VKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV-DALRL 501
Query: 1125 XXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGD-KTKKIGDXXXXXXXXXXX 1183
+ + T+ + + LK++ D K +K+
Sbjct: 502 RLEEKETMLNKKTKQIQDMAE-EKGTQAGEIHD--LKDMLDVKERKVNVLQKKIENLQEQ 558
Query: 1184 CKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVL--ANTHRRLSIELTSEKDELQARFIKTE 1241
+ EKQ+S+ K+RV L A + +IE E+ + R + E
Sbjct: 559 LRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 618
Query: 1242 SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMV 1301
++ +DLK D + K++ L+ ++ K+ + L+ E S +
Sbjct: 619 -----IDNYKKDLK-DLKEKVSLLQGDLSEKEASLLDLK------------EHASSLASS 660
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD-LAKLENXXXXXX 1360
++ Q + K++ + +A +A + + SD + LE
Sbjct: 661 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 720
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
KE++ + + KK+ + + VK+++ ++A LK K ++ +
Sbjct: 721 DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEK 780
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEK 1480
+ S + + ++ ++L+ SL + EEL EE + ++T E+
Sbjct: 781 KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL--------EEALRESVQITAER 832
Query: 1481 EQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEV 1540
E + + + E+ EK+ E + + + Q S+A + L E
Sbjct: 833 EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE- 891
Query: 1541 ERARLNARLDQRERELRAANDRRD 1564
R L L+ ++ L AA +D
Sbjct: 892 RRKHLEEVLEMKQEALLAAISEKD 915
Score = 50.8 bits (116), Expect = 5e-05
Identities = 92/553 (16%), Positives = 208/553 (37%), Gaps = 29/553 (5%)
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKD 1273
+L T + + + ++K L AR + L+++ KA E+ + +A +
Sbjct: 283 LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR--LAEAE 340
Query: 1274 VHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+H+ LE L Q K E + E + R Q + K+ E
Sbjct: 341 MHVHHLESLLEQ----KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+ E+ LKS+ A S + +NK ++ +L + +L
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTEL-- 454
Query: 1394 MRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS---LAL 1450
+A ++ + + K +++L+++ A +R L+ E + +LE L
Sbjct: 455 --LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 512
Query: 1451 EKAEYEELTGKYELLEEEHVVTKARLTVEKEQA---QGELLHVQKELSTALGEIKTLQEK 1507
+ + +++ + E K L V++ + Q ++ ++Q++L ++ +L+E+
Sbjct: 513 KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 572
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+ + A + T ++ +L+E L +ER + D+RE++ N ++D+ +
Sbjct: 573 VKSLQA----DTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 628
Query: 1568 HHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEIT 1627
+ ++ E+ K E +
Sbjct: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME-S 687
Query: 1628 DTKTRYEGQMNT-----MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN--GDK 1680
K +E + M D ++ L +++R++ E + ++ + + E++N DK
Sbjct: 688 QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK 747
Query: 1681 SARI-HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVR 1739
+I S++S ++ KVA L+ + + + + A + L +
Sbjct: 748 DKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDS 807
Query: 1740 LAEMQSRLNEYEE 1752
L + R+ E EE
Sbjct: 808 LRKKDDRIEELEE 820
Score = 43.6 bits (98), Expect = 0.007
Identities = 63/282 (22%), Positives = 125/282 (44%), Gaps = 36/282 (12%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDT-ANKYTTGRSSEVL 320
++ + Y+D+ + EVD L + + VE EK+D +++A +++ ++ ++ +V
Sbjct: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKND-KDKKIAELESLTSRQVKDQNKKVA 770
Query: 321 KLQQK-----------VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ 369
L+ K + E ++L D + L +R+ + +E ++ QI
Sbjct: 771 NLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITA 830
Query: 370 LRAKLLA--------AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
R +LA AE EEL+ E +K+EL + Q + E + ++LR
Sbjct: 831 EREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET-HLTNLR 889
Query: 422 RELEQTIKNCRVLSFKLKK-----TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
E + ++ VL K + +E+ A+ E + +KK E V ++RE
Sbjct: 890 AERRKHLE--EVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA---ALKREK--D 942
Query: 477 ELEQEVARSTEVALRLQRELAEANS-KFTGSNPSLMKVPQPE 517
L Q++ + T+ ++L + E + K + SN + K P P+
Sbjct: 943 RLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHK-PSPD 983
Score = 35.9 bits (79), Expect = 1.5
Identities = 73/422 (17%), Positives = 155/422 (36%), Gaps = 28/422 (6%)
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKI-----LEQNSGA---GAKRITELK 1434
DLQ++ K++ R KDV+ K+++L++ +K L++ A +IT K
Sbjct: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYEL----LEEEHVVTKARLTVEKEQAQGELLHV 1490
++Y ++ +H +A +EL + +L ++ T E + + LH
Sbjct: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Query: 1491 Q-----KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
+ KEL ++ ++ ++ T+ N ++ + LQ + E
Sbjct: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
Query: 1546 NARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
RL + E + + E + D + +Q
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 1606 XXXXXXXXXIEQSEKARKAEITDTKTRYE--GQMNTMRDELKSLHNQVSRFRRERDNYKQ 1663
E+ + + T+ R E QM R K + N++ + ++E
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
Query: 1664 MLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLAS 1723
L A Q + + N ++ H E + + EQ+ A L+ E+ RL
Sbjct: 453 ELLALQTKLETLTNQFSDSKQH--------IEVLKESLTAKEQRAAILQTEVDALRLRLE 504
Query: 1724 KLNTELVSEKSSAEVRLAEMQSRLNE-YEEERLLSSGRARVAGLATRMELAWHKERDEQQ 1782
+ T L + + E ++ E ++ + +L +V L ++E + RD+++
Sbjct: 505 EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEK 564
Query: 1783 RL 1784
++
Sbjct: 565 QM 566
Score = 35.5 bits (78), Expect = 2.0
Identities = 39/175 (22%), Positives = 76/175 (43%), Gaps = 7/175 (4%)
Query: 1620 KARKAEITDTKTR-YEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNG 1678
K RK + K + Q+ ++ SL +V + + N L ++++AE +
Sbjct: 541 KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 600
Query: 1679 DKSARIHRNSISSTDEEE---YRNKVALLEQQVACLEDELC--ESRLLASKLN-TELVSE 1732
+ + R+ +EE Y+ + L+++V+ L+ +L E+ LL K + + L S
Sbjct: 601 IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 660
Query: 1733 KSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQE 1787
+ RL ++ L + +EE L + + A A A + D Q L +E
Sbjct: 661 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE 715
>AB029004-1|BAA83033.2| 1003|Homo sapiens KIAA1081 protein protein.
Length = 1003
Score = 80.2 bits (189), Expect = 7e-14
Identities = 157/777 (20%), Positives = 337/777 (43%), Gaps = 67/777 (8%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL 374
R + ++ LQ ++ E+ N+ LR + + K+ + ++T S E + + LR
Sbjct: 158 RDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA--LRKDE 215
Query: 375 LAAETLCEE----LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL--EQTI 428
+ T+ +E + +EN+ M+ ++ L +D + Q D S E T
Sbjct: 216 ASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE 275
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEV----- 482
+N + L + ER+A +L + E+ L I + R+ IK+L + +
Sbjct: 276 ENFQRLH---AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 332
Query: 483 -ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
A++TE R LAEA SL++ + E + R + D A+ +
Sbjct: 333 SAKATEEDHERTRRLAEAEMHVHHLE-SLLEQKEKENSMLREEMHRRFENAPDSAKT-KA 390
Query: 542 LQDSLERE----ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LQ +E + + + LR+ EEE K L + + + +++ S +
Sbjct: 391 LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA---LSTEEREEEMKQMEVYRSHS--K 445
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
++NK I S++ ++ L T QF ++ + ++ AA +
Sbjct: 446 FMKNK-IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR-AAIL 503
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELN 717
+ + ++L L+L++ T NK + + + +EK T + ++K +L++
Sbjct: 504 QTEVDALRLRLEEKETML-----------NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 552
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE- 776
E++ VL++K+E L++ +KQ+ L ++ S+ + ++T +LTT LAE
Sbjct: 553 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT----ALTTLEEALAEK 608
Query: 777 ----ERVKVLEDEIDEVRKKLIEK-ERDCERLHAELSLAQ----KKPKTLIKSRSLDASD 827
ER+K D + +++ I+ ++D + L ++SL Q +K +L+ + AS
Sbjct: 609 ERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE-HASS 667
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
+ LK+ ++ E ++ + K + L+ +++ + L+ A SD+ L
Sbjct: 668 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE--ARASPEMSDRIQHLE- 724
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++ T+ ++E +A A++ L I ++ ++EK + + E ++L S+Q
Sbjct: 725 REITRYKDESSKAQAEVDRLLEILKEVENEKNDK--DKKIAELESLTSRQVKDQNKKVAN 782
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK-KMVEDLECEIGE-MYV 1005
++ + ++A++ + + L L+ K +E+LE + E + +
Sbjct: 783 LKHKEQVEKKKSA--QMLEEARRR-EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI 839
Query: 1006 VMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
+ + +E +A+T EK+++E+ + K E + K +L + L + L
Sbjct: 840 TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 896
Score = 58.8 bits (136), Expect = 2e-07
Identities = 146/804 (18%), Positives = 306/804 (38%), Gaps = 63/804 (7%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKT-----LIKSRSLDASDQQNVDL-KR 835
L+ ++ EV ++ +D E ++LS + KT L K R+L + + + K
Sbjct: 165 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 224
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK--ALDLNTKKTTQL 893
Q +V+++E ++ Q+L+ ++L+ + QL + S R+ + +L + +L
Sbjct: 225 QYRVVQEENQHMQMTIQALQ---DELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 281
Query: 894 ----ENELKEA--LAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
E + KE L K ++E+E+ + +K R E+ KK + L+SK
Sbjct: 282 HAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEMLQSKGLSAKATEED 340
Query: 947 XXXXXXXXXXXQAT--LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L+SL + +K + + + + + +
Sbjct: 341 HERTRRLAEAEMHVHHLESLLEQKEKE------NSMLREEMHRRFENAPDSAKTKALQTV 394
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ MK++ +S E + LE+EI ++S + + E E +++ + K + K+
Sbjct: 395 IEMKDSKISSMERGLRD-LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQ 453
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXX 1124
K + K L + L ++ ++ E L+A + A LQT + D +
Sbjct: 454 VKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV-DALRL 512
Query: 1125 XXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGD-KTKKIGDXXXXXXXXXXX 1183
+ + T+ + + LK++ D K +K+
Sbjct: 513 RLEEKETMLNKKTKQIQDMAE-EKGTQAGEIHD--LKDMLDVKERKVNVLQKKIENLQEQ 569
Query: 1184 CKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVL--ANTHRRLSIELTSEKDELQARFIKTE 1241
+ EKQ+S+ K+RV L A + +IE E+ + R + E
Sbjct: 570 LRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 629
Query: 1242 SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMV 1301
++ +DLK D + K++ L+ ++ K+ + L+ E S +
Sbjct: 630 -----IDNYKKDLK-DLKEKVSLLQGDLSEKEASLLDLK------------EHASSLASS 671
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD-LAKLENXXXXXX 1360
++ Q + K++ + +A +A + + SD + LE
Sbjct: 672 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 731
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
KE++ + + KK+ + + VK+++ ++A LK K ++ +
Sbjct: 732 DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEK 791
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEK 1480
+ S + + ++ ++L+ SL + EEL EE + ++T E+
Sbjct: 792 KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL--------EEALRESVQITAER 843
Query: 1481 EQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEV 1540
E + + + E+ EK+ E + + + Q S+A + L E
Sbjct: 844 EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE- 902
Query: 1541 ERARLNARLDQRERELRAANDRRD 1564
R L L+ ++ L AA +D
Sbjct: 903 RRKHLEEVLEMKQEALLAAISEKD 926
Score = 50.8 bits (116), Expect = 5e-05
Identities = 92/553 (16%), Positives = 208/553 (37%), Gaps = 29/553 (5%)
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKD 1273
+L T + + + ++K L AR + L+++ KA E+ + +A +
Sbjct: 294 LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR--LAEAE 351
Query: 1274 VHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+H+ LE L Q K E + E + R Q + K+ E
Sbjct: 352 MHVHHLESLLEQ----KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 407
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+ E+ LKS+ A S + +NK ++ +L + +L
Sbjct: 408 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTEL-- 465
Query: 1394 MRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS---LAL 1450
+A ++ + + K +++L+++ A +R L+ E + +LE L
Sbjct: 466 --LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 523
Query: 1451 EKAEYEELTGKYELLEEEHVVTKARLTVEKEQA---QGELLHVQKELSTALGEIKTLQEK 1507
+ + +++ + E K L V++ + Q ++ ++Q++L ++ +L+E+
Sbjct: 524 KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 583
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+ + A + T ++ +L+E L +ER + D+RE++ N ++D+ +
Sbjct: 584 VKSLQA----DTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 639
Query: 1568 HHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEIT 1627
+ ++ E+ K E +
Sbjct: 640 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME-S 698
Query: 1628 DTKTRYEGQMNT-----MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN--GDK 1680
K +E + M D ++ L +++R++ E + ++ + + E++N DK
Sbjct: 699 QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK 758
Query: 1681 SARI-HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVR 1739
+I S++S ++ KVA L+ + + + + A + L +
Sbjct: 759 DKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDS 818
Query: 1740 LAEMQSRLNEYEE 1752
L + R+ E EE
Sbjct: 819 LRKKDDRIEELEE 831
Score = 43.6 bits (98), Expect = 0.007
Identities = 63/282 (22%), Positives = 125/282 (44%), Gaps = 36/282 (12%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDT-ANKYTTGRSSEVL 320
++ + Y+D+ + EVD L + + VE EK+D +++A +++ ++ ++ +V
Sbjct: 723 LEREITRYKDESSKAQAEVDRLLEILKEVENEKND-KDKKIAELESLTSRQVKDQNKKVA 781
Query: 321 KLQQK-----------VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ 369
L+ K + E ++L D + L +R+ + +E ++ QI
Sbjct: 782 NLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITA 841
Query: 370 LRAKLLA--------AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
R +LA AE EEL+ E +K+EL + Q + E + ++LR
Sbjct: 842 EREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET-HLTNLR 900
Query: 422 RELEQTIKNCRVLSFKLKK-----TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
E + ++ VL K + +E+ A+ E + +KK E V ++RE
Sbjct: 901 AERRKHLE--EVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA---ALKREK--D 953
Query: 477 ELEQEVARSTEVALRLQRELAEANS-KFTGSNPSLMKVPQPE 517
L Q++ + T+ ++L + E + K + SN + K P P+
Sbjct: 954 RLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHK-PSPD 994
Score = 35.9 bits (79), Expect = 1.5
Identities = 73/422 (17%), Positives = 155/422 (36%), Gaps = 28/422 (6%)
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKI-----LEQNSGA---GAKRITELK 1434
DLQ++ K++ R KDV+ K+++L++ +K L++ A +IT K
Sbjct: 164 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 223
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYEL----LEEEHVVTKARLTVEKEQAQGELLHV 1490
++Y ++ +H +A +EL + +L ++ T E + + LH
Sbjct: 224 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 283
Query: 1491 Q-----KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
+ KEL ++ ++ ++ T+ N ++ + LQ + E
Sbjct: 284 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 343
Query: 1546 NARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
RL + E + + E + D + +Q
Sbjct: 344 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 403
Query: 1606 XXXXXXXXXIEQSEKARKAEITDTKTRYE--GQMNTMRDELKSLHNQVSRFRRERDNYKQ 1663
E+ + + T+ R E QM R K + N++ + ++E
Sbjct: 404 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 463
Query: 1664 MLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLAS 1723
L A Q + + N ++ H E + + EQ+ A L+ E+ RL
Sbjct: 464 ELLALQTKLETLTNQFSDSKQH--------IEVLKESLTAKEQRAAILQTEVDALRLRLE 515
Query: 1724 KLNTELVSEKSSAEVRLAEMQSRLNE-YEEERLLSSGRARVAGLATRMELAWHKERDEQQ 1782
+ T L + + E ++ E ++ + +L +V L ++E + RD+++
Sbjct: 516 EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEK 575
Query: 1783 RL 1784
++
Sbjct: 576 QM 577
Score = 35.5 bits (78), Expect = 2.0
Identities = 39/175 (22%), Positives = 76/175 (43%), Gaps = 7/175 (4%)
Query: 1620 KARKAEITDTKTR-YEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNG 1678
K RK + K + Q+ ++ SL +V + + N L ++++AE +
Sbjct: 552 KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 611
Query: 1679 DKSARIHRNSISSTDEEE---YRNKVALLEQQVACLEDELC--ESRLLASKLN-TELVSE 1732
+ + R+ +EE Y+ + L+++V+ L+ +L E+ LL K + + L S
Sbjct: 612 IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 671
Query: 1733 KSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQE 1787
+ RL ++ L + +EE L + + A A A + D Q L +E
Sbjct: 672 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE 726
>AL031058-1|CAA19927.1| 2871|Homo sapiens desmoplakin protein.
Length = 2871
Score = 79.8 bits (188), Expect = 9e-14
Identities = 225/1168 (19%), Positives = 441/1168 (37%), Gaps = 102/1168 (8%)
Query: 662 ESLLLQLKKMATKARS--RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQ 719
+SLL +K KA+ + S P L + + + TD + ++ L +
Sbjct: 822 KSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDL 881
Query: 720 EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERV 779
E + +++ + +A K + + + S+ G + T R L N +E
Sbjct: 882 EKQI--KQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISG 939
Query: 780 KV-LEDEIDEVRKKLIEKERDCERLHA------ELSLAQKKPKTLIKSRSLDASDQQNVD 832
K +E+ ++ + +D E A E L +T+I+S S Q+ D
Sbjct: 940 KRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPS-GVILQEAAD 998
Query: 833 LK-RQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK---------NAKSLRSDKA 882
+ R ++++ + R ++ L++ E L+ +N K+++L+ N+++ +K
Sbjct: 999 VHARYIELLTRSGDYYRFLSEMLKS-LEDLKLKNTKIEVLEEELRLARDANSENCNKNKF 1057
Query: 883 LDLNTKKTTQLENELKEALAKIKELEMICQ-DEKSEKKVRFTEATKKETDTLKSKQXXXX 941
LD N +K ++ K LA ++EL+ + D KS K + K +K
Sbjct: 1058 LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAK-----QNLDKCYGQIKELNEKIT 1112
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ K+D + K R +K KL+ +K +++ E EI
Sbjct: 1113 RLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIE 1172
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI----AKLKD 1057
+ V+++ G T K + E E+ ++R+ ++ E +N +N+ +TEI +K+
Sbjct: 1173 RLRVLLQEEG------TRKREYENELAKVRNHYNE---EMSNLRNKYETEINITKTTIKE 1223
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
++ + E D N+ L EN +L ++ L + + Q + +NA +
Sbjct: 1224 ISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAE---ENALQQKAC 1280
Query: 1118 MSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXX 1177
S+ M DN + Q + K + DK K+I
Sbjct: 1281 GSEIMQKKQHLEIELKQVMQQRSE-----DN-ARHKQSLEEAAKTIQDKNKEIERLKAEF 1334
Query: 1178 XXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARF 1237
E +LS ++ + + T +LT +K+E + +
Sbjct: 1335 QEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIH---QLTMQKEEDTSGY 1391
Query: 1238 IKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQ--TTNDKYDEAT 1295
++ L E R L + I L++T+ +++++E+ ++Q T + +
Sbjct: 1392 ---RAQIDNLTRENRSLSEE----IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRK 1444
Query: 1296 SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENX 1355
+E VE+R + L++A ++ E K + + +D LE+
Sbjct: 1445 QQLE-VELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDE 1503
Query: 1356 XXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGK 1415
+S A E L+ + ++L R+RI +++ + + T+K +
Sbjct: 1504 NARLQRVQYDLQKANS----SATETINKLKVQEQELTRLRIDYERVSQER-----TVKDQ 1554
Query: 1416 LKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKAR 1475
QNS K + KQ+ EE + +L+ + + + K + LEEE +
Sbjct: 1555 DITRFQNS---LKELQLQKQKVEEELNRLKRTASEDSC-------KRKKLEEELEGMRRS 1604
Query: 1476 LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCG 1535
L KEQA ++ ++ ++L A K ++ L + + E Q + QE L
Sbjct: 1605 L---KEQAI-KITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRT----QEELRR 1656
Query: 1536 GGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQR 1595
EVE R +L Q + ++ A+ R EH + ER+ +
Sbjct: 1657 LSSEVEALR--RQLLQEQESVKQAHLRN---EHFQKAIEDKSRSLNESKIEIERLQSLTE 1711
Query: 1596 XXXXXXXXXXXXXXXXXXXIEQSEKARKAEITD---TKTRYEGQMNTMRDELKSLHNQVS 1652
+ + R +D T Q+ + L ++
Sbjct: 1712 NLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLIN 1771
Query: 1653 RFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLE 1712
+RER+N +Q +E QK E N + ++ + + E K+ +LEQ A L+
Sbjct: 1772 DLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-ERESLLVKIKVLEQDKARLQ 1830
Query: 1713 DELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRAR-VAGLATRME 1771
E S L E K E ++Q+ LN+++ + R + + E
Sbjct: 1831 RLEDELNRAKSTLEAE-TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSE 1889
Query: 1772 LAWHKERDEQQRLLQETSTLARDLRQTL 1799
+ R E +RL E + R+ L
Sbjct: 1890 REKNSLRSEIERLQAEIKRIEERCRRKL 1917
Score = 76.2 bits (179), Expect = 1e-12
Identities = 166/857 (19%), Positives = 363/857 (42%), Gaps = 92/857 (10%)
Query: 267 KEYQ-DQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
KEY+ +++ L QE ++ E + + ++N+ NKY T + +++
Sbjct: 1167 KEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNL--RNKYETEINITKTTIKEI 1224
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +++LR++ L+++ R+++ E+ S T Q + L + E+
Sbjct: 1225 SMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEI 1284
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER- 443
M + + ++ EL+ + +DN R Q+ E E +TI++ K K+ ER
Sbjct: 1285 MQKKQHLEIELKQVMQQRS--EDNARHKQSLE------EAAKTIQD------KNKEIERL 1330
Query: 444 KADQLEQEKA--EHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELAEA 499
KA+ E+ K E+E +L ++ D + +N+ E E + ++T L +Q+E E
Sbjct: 1331 KAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQF-ETEINITKTTIHQLTMQKE--ED 1387
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
S + +L + + + ++ R T + E+ ++ D+Q +++ ++ +
Sbjct: 1388 TSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQL 1447
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E E Q+ + + D+ ++T+ + +NK I KE +D
Sbjct: 1448 EVELRQVTQMRTEESVRYKQSLDDA-------AKTIQD--KNKEIERLKQLIDKETNDRK 1498
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRK 679
L D+ + +DL N A + K + E++ L + ++++ + +
Sbjct: 1499 CLE-DENARLQRVQYDLQKA---NSSATETINKLKVQ-EQELTRLRIDYERVSQERTVKD 1553
Query: 680 LSPTPPANKLS-IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEAL 738
T N L ++ E+E + L+ E + R+K+EE + E +
Sbjct: 1554 QDITRFQNSLKELQLQKQKVEEELNR---------LKRTASEDSCKRKKLEE---ELEGM 1601
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRS---LTTNSNKL---------AEERVKVLEDEI 786
++ +KE KI+++T+ ++ +RS L + L +E ++ L E+
Sbjct: 1602 RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEV 1661
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+ +R++L++++ ++ H QK + KSRSL+ S + L+ + + +E +
Sbjct: 1662 EALRRQLLQEQESVKQAHLRNEHFQKAIED--KSRSLNESKIEIERLQSLTENLTKEHLM 1719
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L + ++L + + L+ + KNA L L ++ +T +L+ + + + +
Sbjct: 1720 LEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQREREN 1779
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
L + EK +K+ EA+ + ++ K++ +A L+ L+D
Sbjct: 1780 LRQ--EIEKFQKQA--LEASNRIQES-KNQCTQVVQERESLLVKIKVLEQDKARLQRLED 1834
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
+ ++ K + T+++ + LECE + + + + + K + ++
Sbjct: 1835 ELNRA------KSTLEAETRVK-----QRLECEKQQ---IQNDLNQWKTQYSRKEEAIRK 1880
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKYKALENENSNLSN 1085
I+ R K + + +E RLQ EI ++++ KLE D LE E S
Sbjct: 1881 IESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLE---DSTRETQSQLETERSRYQR 1937
Query: 1086 QCKTLTEEM--KNREAQ 1100
+ L + +RE Q
Sbjct: 1938 EIDKLRQRPYGSHRETQ 1954
>M77830-1|AAA85135.1| 2871|Homo sapiens desmoplakin I protein.
Length = 2871
Score = 79.4 bits (187), Expect = 1e-13
Identities = 188/961 (19%), Positives = 361/961 (37%), Gaps = 81/961 (8%)
Query: 852 QSLEADNEKLQTENKKLQLLKNAKS--LRSDKALDLNTKKTTQLENELKEALAKIKELEM 909
+ L+ N K++ ++L+L ++A S +K LD N +K ++ K LA ++EL+
Sbjct: 1025 EDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR 1084
Query: 910 ICQ-DEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ D KS K + K +K + K+D
Sbjct: 1085 QAELDGKSAK-----QNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
+ K R +K KL+ +K +++ E EI + V+++ G T K + E E+
Sbjct: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEG------TRKREYENELA 1193
Query: 1029 EIRSKLSKNDSEFTNEKNRLQTEI----AKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
++R+ ++ E +N +N+ +TEI +K+++ + E D N+ L EN +L
Sbjct: 1194 KVRNHYNE---EMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLK 1250
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
++ L + + Q + +NA + S+ M
Sbjct: 1251 DEIVRLNDSILQATEQRRRAE---ENALQQKACGSEIMQKKQHLEIELKQVMQQRSE--- 1304
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
DN + Q + K + DK K+I E +LS ++
Sbjct: 1305 --DN-ARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIIS 1361
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITS 1264
+ + T +LT +K+E + + ++ L E R L + I
Sbjct: 1362 LKNQFETEINITKTTIH---QLTMQKEEDTSGY---RAQIDNLTRENRSLSEE----IKR 1411
Query: 1265 LESTIAAKDVHIKQLEDALRQ--TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELN 1322
L++T+ +++++E+ ++Q T + + +E VE+R + L+
Sbjct: 1412 LKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLE-VELRQVTQMRTEESVRYKQSLD 1470
Query: 1323 NAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDT 1382
+A ++ E K + + +D LE+ +S A E
Sbjct: 1471 DAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANS----SATETIN 1526
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVK 1442
L+ + ++L R+RI +++ + + T+K + QNS K + KQ+ EE +
Sbjct: 1527 KLKVQEQELTRLRIDYERVSQER-----TVKDQDITRFQNS---LKELQLQKQKVEEELN 1578
Query: 1443 KLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIK 1502
+L+ + + + K + LEEE + L KEQA ++ ++ ++L A K
Sbjct: 1579 RLKRTASEDSC-------KRKKLEEELEGMRRSL---KEQAI-KITNLTQQLEQASIVKK 1627
Query: 1503 TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
++ L + + E Q + QE L EVE R +L Q + ++ A+ R
Sbjct: 1628 RSEDDLRQQRDVLDGHLREKQRT----QEELRRLSSEVEALR--RQLLQEQESVKQAHLR 1681
Query: 1563 RDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
EH + ER+ + + + R
Sbjct: 1682 N---EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGR 1738
Query: 1623 KAEITD---TKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGD 1679
+D T Q+ + L ++ +RER+N +Q +E QK E N
Sbjct: 1739 SEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRI 1798
Query: 1680 KSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVR 1739
+ ++ + + E K+ +LEQ A L+ E S L E K E
Sbjct: 1799 QESKNQCTQVVQ-ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE-TRVKQRLECE 1856
Query: 1740 LAEMQSRLNEYEEERLLSSGRAR-VAGLATRMELAWHKERDEQQRLLQETSTLARDLRQT 1798
++Q+ LN+++ + R + + E + R E +RL E + R+
Sbjct: 1857 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRK 1916
Query: 1799 L 1799
L
Sbjct: 1917 L 1917
Score = 76.2 bits (179), Expect = 1e-12
Identities = 166/857 (19%), Positives = 363/857 (42%), Gaps = 92/857 (10%)
Query: 267 KEYQ-DQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
KEY+ +++ L QE ++ E + + ++N+ NKY T + +++
Sbjct: 1167 KEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNL--RNKYETEINITKTTIKEI 1224
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +++LR++ L+++ R+++ E+ S T Q + L + E+
Sbjct: 1225 SMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEI 1284
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER- 443
M + + ++ EL+ + +DN R Q+ E E +TI++ K K+ ER
Sbjct: 1285 MQKKQHLEIELKQVMQQRS--EDNARHKQSLE------EAAKTIQD------KNKEIERL 1330
Query: 444 KADQLEQEKA--EHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELAEA 499
KA+ E+ K E+E +L ++ D + +N+ E E + ++T L +Q+E E
Sbjct: 1331 KAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQF-ETEINITKTTIHQLTMQKE--ED 1387
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
S + +L + + + ++ R T + E+ ++ D+Q +++ ++ +
Sbjct: 1388 TSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQL 1447
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E E Q+ + + D+ ++T+ + +NK I KE +D
Sbjct: 1448 EVELRQVTQMRTEESVRYKQSLDDA-------AKTIQD--KNKEIERLKQLIDKETNDRK 1498
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRK 679
L D+ + +DL N A + K + E++ L + ++++ + +
Sbjct: 1499 CLE-DENARLQRVQYDLQKA---NSSATETINKLKVQ-EQELTRLRIDYERVSQERTVKD 1553
Query: 680 LSPTPPANKLS-IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEAL 738
T N L ++ E+E + L+ E + R+K+EE + E +
Sbjct: 1554 QDITRFQNSLKELQLQKQKVEEELNR---------LKRTASEDSCKRKKLEE---ELEGM 1601
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRS---LTTNSNKL---------AEERVKVLEDEI 786
++ +KE KI+++T+ ++ +RS L + L +E ++ L E+
Sbjct: 1602 RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEV 1661
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+ +R++L++++ ++ H QK + KSRSL+ S + L+ + + +E +
Sbjct: 1662 EALRRQLLQEQESVKQAHLRNEHFQKAIED--KSRSLNESKIEIERLQSLTENLTKEHLM 1719
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L + ++L + + L+ + KNA L L ++ +T +L+ + + + +
Sbjct: 1720 LEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQREREN 1779
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
L + EK +K+ EA+ + ++ K++ +A L+ L+D
Sbjct: 1780 LRQ--EIEKFQKQA--LEASNRIQES-KNQCTQVVQERESLLVKIKVLEQDKARLQRLED 1834
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
+ ++ K + T+++ + LECE + + + + + K + ++
Sbjct: 1835 ELNRA------KSTLEAETRVK-----QRLECEKQQ---IQNDLNQWKTQYSRKEEAIRK 1880
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKYKALENENSNLSN 1085
I+ R K + + +E RLQ EI ++++ KLE D LE E S
Sbjct: 1881 IESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLE---DSTRETQSQLETERSRYQR 1937
Query: 1086 QCKTLTEEM--KNREAQ 1100
+ L + +RE Q
Sbjct: 1938 EIDKLRQRPYGSHRETQ 1954
Score = 64.5 bits (150), Expect = 4e-09
Identities = 137/791 (17%), Positives = 294/791 (37%), Gaps = 55/791 (6%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
E++L + N + K + L+Q+ + + + + +K++S+ + + + S
Sbjct: 1040 ELRLARDANSENCN----KNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGK-SAK 1094
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
N +K + +K L ++I + ++ +++R + + + L K+R + +
Sbjct: 1095 QNLDKCYGQ-IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL----KNAKSLRSDKALD 884
L+ + + E+E + R + E K + EN+ ++ + +LR+ +
Sbjct: 1154 GWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETE 1213
Query: 885 LNTKKTT------QLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
+N KTT Q E++ K ++ L +D K E VR ++ + T+ + +
Sbjct: 1214 INITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDE-IVRLNDSILQATEQRRRAEE 1272
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC 998
+ LK + Q+S K+ + + K ++D
Sbjct: 1273 NALQQKACGSEIMQKKQHLEIELKQVMQ--QRSEDNARHKQSLE-----EAAKTIQDKNK 1325
Query: 999 EIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDV 1058
EI + + +E + + E E+ ++R+ D E + KN+ +TEI K
Sbjct: 1326 EIERLKAEFQ------EEAKRRWEYENELSKVRNNY---DEEIISLKNQFETEINITKTT 1376
Query: 1059 NAKLEGDKDVFANKYKA----LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSL 1114
+L K+ + Y+A L EN +LS + K L + + ++ D++ +
Sbjct: 1377 IHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKAT 1436
Query: 1115 QTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ-VDNYTKIDQDKNKLLKEVGDKTKKIGDX 1173
+ +S Q +D+ K QDKNK ++ + K +
Sbjct: 1437 GSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETND 1496
Query: 1174 XXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL 1233
+R++ L T + L + R+S E T KD+
Sbjct: 1497 RKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERT-VKDQD 1555
Query: 1234 QARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDE 1293
RF + K + L+ K E ++ L+ T + K+LE+ L ++
Sbjct: 1556 ITRF-QNSLKELQLQ------KQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQ 1608
Query: 1294 ATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLE 1353
A +++ + +D+L + L+ E + E+ +L S++ L
Sbjct: 1609 A---IKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALR 1665
Query: 1354 NXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLK 1413
+ +++ ++ L + +++R++ +N E L+
Sbjct: 1666 RQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSL----TENLTKEHLMLE 1721
Query: 1414 GKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK 1473
+L+ L + +E + T+ +L L + EL G L+ E
Sbjct: 1722 EELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER--EN 1779
Query: 1474 ARLTVEKEQAQ 1484
R +EK Q Q
Sbjct: 1780 LRQEIEKFQKQ 1790
>BX284668-3|CAH70057.1| 1898|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 1898
Score = 79.4 bits (187), Expect = 1e-13
Identities = 243/1295 (18%), Positives = 491/1295 (37%), Gaps = 88/1295 (6%)
Query: 292 KEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT-HNEDLRDEKKHLTQKIREI 350
+E++ +L + L+ ++ + E+ V+E T H++DL + IR
Sbjct: 51 QEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERDTEHSQDLE------SALIRLE 104
Query: 351 ESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDM---KKELRDLXXXXXXMQD 407
E + + + EQL A + L E++ D +KEL ++
Sbjct: 105 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEE 164
Query: 408 NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEI-VGGP 466
+F ++E+S L Q + R++S TER QL E A + + E +G
Sbjct: 165 SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLS 224
Query: 467 DGMQ-RENRIKE-LEQEVARSTEVALRLQ-RELAEANSKFTGSNPSLMKVPQPETVKVSR 523
G++ E+R + LE++ ++ +L+ + L E + L K V
Sbjct: 225 TGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELG 284
Query: 524 SSLTRGGSQE-DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
++ R Q + Q+ +DL + LE LR Q + A E L + V++D
Sbjct: 285 LAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSD 344
Query: 583 NIVTCDIHESETVTNSIQNKM--IHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLS 640
+ + SE ++ + + TPS +S SP + D L+
Sbjct: 345 SESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRS-SPGRGRSPRRGPSPACSDSSTLA 403
Query: 641 IFN---HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDN 697
+ + H ++ R E ++ LL L+K + + S + + +L +T
Sbjct: 404 LIHSALHKRQLQVQDMRGRYEA-SQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM 462
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
E + + ++ EL +E + L ++ +Q E L+++ ++L +
Sbjct: 463 QAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQA---------- 512
Query: 758 GSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTL 817
A+ L ++L EE+ ++D VR++L R E+L + S+ K+ +
Sbjct: 513 -----AQEELRRQRDRLEEEQEDAVQDGA-RVRRELERSHRQLEQLEGKRSVLAKELVEV 566
Query: 818 IKSRSL-----DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
++ S D + ++ L E L L A+ LQ KL L
Sbjct: 567 REALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALN 626
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+SL DK LDLN + QLE E + ++ E + E++ R E ++
Sbjct: 627 --ESLAQDK-LDLN-RLVAQLEEEKSALQGRQRQAEQEATVAREEQE-RLEELRLEQEVA 681
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
+ + + L++ + + ++ + + ++
Sbjct: 682 RQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQ 741
Query: 993 VEDLECEIGEMYVVMK-NAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
VE LE E + K +AGL+ ++ A + + + E ++L +Q +
Sbjct: 742 VEALERAAREKEALAKEHAGLA-VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQ 800
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK-NREAQINKL-SADLK 1109
+A+L+ +LE + + L E + L Q E+ ++E KL A+ +
Sbjct: 801 LAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAERE 860
Query: 1110 NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKK 1169
SL+ + Q+ + ++ +++ +LL + + ++
Sbjct: 861 AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQS--QLQREQEELLARLEAEKEE 918
Query: 1170 IGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSE 1229
+ + + + S ++ ++ + + ++ +S+E+ +
Sbjct: 919 LSEEIAALQQERDEGLLLAE--SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQ 976
Query: 1230 KDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
K + Q+R + S L +E+RDL+A E AA +++L++ R
Sbjct: 977 KRDAQSRQEQDRSTVNALTSELRDLRA-------QREEAAAAHAQEVRRLQEQARDLGKQ 1029
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
+ D E E+R + EL A+ KL +++ + E +L+ L
Sbjct: 1030 R-DSCLREAE--ELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSL 1086
Query: 1350 AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL 1409
E S+ + +++ + L +E K+ + + K+A
Sbjct: 1087 G--EGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEA-- 1142
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLE--- 1466
L+ L+ +E++ + + EL+++ +K L+ E EL G+ L E
Sbjct: 1143 GELRTGLQEVERSRLEARRELQELRRQ----MKMLDSENTRLGRELAELQGRLALGERAE 1198
Query: 1467 ----EEHVVTKARL---TVEKEQAQGELLHVQKELSTALGEIKTLQEK-LGTESAAWNTE 1518
E + + RL E + EL Q++L GE +T + + LG+ A TE
Sbjct: 1199 KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTE 1258
Query: 1519 KTEMQNSIASLQERLCGGGWEVERARLNARLDQRE 1553
K ++ ++ L+ +L E A L RL E
Sbjct: 1259 KQQLDHA-RGLELKLEAA--RAEAAELGLRLSAAE 1290
Score = 68.5 bits (160), Expect = 2e-10
Identities = 136/703 (19%), Positives = 276/703 (39%), Gaps = 54/703 (7%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTG 314
+ +E + + E L+ + LR++ +R+E+E+ D + R L + G
Sbjct: 495 VAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEG 554
Query: 315 RSS----EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQ 369
+ S E++++++ ++ T + L+ EK + + + + E+ +E S +
Sbjct: 555 KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEAS 614
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
L+ L L E L + D+ + + L +Q R+ QA++ +++ RE ++ ++
Sbjct: 615 LQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQG--RQRQAEQEATVAREEQERLE 672
Query: 430 NCRV--------LSFKLKKTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELE 479
R+ L L+ E+ + LEQ+ HE+ L+ Q R +ELE
Sbjct: 673 ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 732
Query: 480 Q---EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA 536
Q E R E R RE + G L+ + G + + A
Sbjct: 733 QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER------------EGRTLSEEA 780
Query: 537 QLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETV 595
LR +++LE +++ QL E + L K+ +T + T
Sbjct: 781 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQ 840
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
+ +K + A ++ ++ + EE + + + A + +
Sbjct: 841 EKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER-AQLQS 899
Query: 656 RVEEDNESLL--LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+++ + E LL L+ +K L L E+ + A + L
Sbjct: 900 QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 959
Query: 714 LELNEQEATV---LRRKVEELEQDKEALKKQVKELTSKISSV---TKTSAGSNTTARRSL 767
+ AT+ + R+ + + +E + V LTS++ + + +A ++ R L
Sbjct: 960 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1019
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD 827
+ L ++R L E +E+R +L E + L EL AQ+K + + R +
Sbjct: 1020 QEQARDLGKQRDSCLR-EAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR--EVQR 1076
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL---KNAKSLRSDKALD 884
Q+ +L+R L +E LR + L + +K ++E L+L K K ++A
Sbjct: 1077 QEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART 1136
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
K+ +L L+E E Q+ + + K+ +E T+
Sbjct: 1137 AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTR 1179
Score = 64.5 bits (150), Expect = 4e-09
Identities = 130/638 (20%), Positives = 264/638 (41%), Gaps = 50/638 (7%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKI 347
E + ++K D L R +A ++ GR + + E E+LR E++ Q +
Sbjct: 627 ESLAQDKLD-LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGL 685
Query: 348 R-EIESELETRPSTEAQTRQIEQLRAKLLAA-ETLCEELMDENEDMKKELRDLXXXXXXM 405
+ + + + E Q + R++L L +L +++++ R+ +
Sbjct: 686 EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEAL 745
Query: 406 QDNFREDQA--DEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
+ RE +A E++ L +L + R LS + + + + LE E +++L ++
Sbjct: 746 ERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLE 805
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ ++ E + L +E LR Q+ +A K+ Q E +
Sbjct: 806 ARREQLEAEGQALLLAKETLTGELAGLR-QQIIATQEKASLDKELMAQKLVQAEREAQAS 864
Query: 524 SSLTRGGSQEDPAQLLRDLQDS---LERE-ADLREQLRNAEEET-----ANCKQVNPPTF 574
R +ED +L R+ + + LE E A L+ QL+ +EE A ++++
Sbjct: 865 LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIA 924
Query: 575 LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHF 634
+Q + ++ + + + ++ K + ++ + L +++ + Q
Sbjct: 925 ALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQ 984
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS---RKLSPTPPANKLS- 690
+ ++ + + LR A+ EE + +++++ +AR ++ S A +L
Sbjct: 985 EQDRSTV--NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRT 1042
Query: 691 ----IETANDNDEKETDEADPA--EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKE 744
+E A D +E EA E + E+ QEA LRR + E +++EAL++ +E
Sbjct: 1043 QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEE 1102
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDEIDEVRKKLIEKERDCER 802
L S + K + + + + KLA EE + E E+R L E ER R
Sbjct: 1103 LRSAV----KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER--SR 1156
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV-LRAKTQSLEADNEKL 861
L A L + + R + D +N L R+L ++ ++ RA+ +S +
Sbjct: 1157 LEARRELQELR-------RQMKMLDSENTRLGRELAELQGRLALGERAEKES------RR 1203
Query: 862 QTENKKLQLLKNAKSLR-SDKALDLNTKKTTQLENELK 898
+T + +LLK SL + L + +K + E E +
Sbjct: 1204 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1241
Score = 60.5 bits (140), Expect = 6e-08
Identities = 147/821 (17%), Positives = 320/821 (38%), Gaps = 68/821 (8%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E L++ + LR ++ E E+ + +LAN D K + + ++ EL T
Sbjct: 1094 EALRRSNEELRSAVKKAESERISL---KLANEDKEQKLALLEEARTA-VGKEAGELRTGL 1149
Query: 334 EDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELMDENEDMK 392
+++ + ++++E+ +++ S + R++ +L+ +L E +E E ++
Sbjct: 1150 QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR 1209
Query: 393 KELRDLXXXXXXMQDNFR------EDQADEYSSLRRELEQTIKNCRVLSFK----LKKTE 442
+ L M+ + ++Q E+ + R L +++ R + + E
Sbjct: 1210 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE 1269
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR--LQRELAEAN 500
K + E AE +L G G++ E E+++ A + LR L+R L
Sbjct: 1270 LKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGR 1329
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTR--------GGSQEDPAQLLRDLQDSLEREADL 552
+ P + + S L G P L+ EA +
Sbjct: 1330 APSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA-V 1388
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
R LR +E + ++ D+ + + + E E +S ++ A +
Sbjct: 1389 RGALREFLQELRSAQRER-----DELRTQTSALNRQLAEMEAERDSATSR---ARQLQKA 1440
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
+S+ S+D Q L S+ + R T +V SL Q +
Sbjct: 1441 VAESEEARRSVDGRLSGVQAELALQEESV--RRSERERRATLDQVATLERSL--QATESE 1496
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV--EE 730
+A K+S AN+ +E ++ D ++ +KL L+ E + R ++ +
Sbjct: 1497 LRASQEKISKMK-ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1555
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
E +AL+ +V L +++ ++ AG+ L K+ EE L D++ +
Sbjct: 1556 REAQAQALQDRVDSLQRQVAD-SEVKAGTLQLTVERLNGALAKV-EESEGALRDKVRGLT 1613
Query: 791 KKLIEKERDC-----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ L + + LH + +L + + LDA+ Q + ++Q + ++
Sbjct: 1614 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1673
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
LR + LE ++++ E + QL + + + +A LNT + Q E L + ++
Sbjct: 1674 TLRGEVADLEL--QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQE--RLG 1729
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
L+ ++EK+ A + E D + ++ + L+S +
Sbjct: 1730 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVE--------------REKLRSHE 1775
Query: 966 DDAQKSF-KPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
D + S K R+ + T +L + ++ ++ LE ++ + A L + +L
Sbjct: 1776 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL 1835
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
++E++ +RS ++ + + + + L++ + L+G
Sbjct: 1836 QQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1876
Score = 55.6 bits (128), Expect = 2e-06
Identities = 119/631 (18%), Positives = 233/631 (36%), Gaps = 49/631 (7%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTES-- 1242
+ +E+QL +D+ + L + + LS E ++ LQ + E
Sbjct: 445 RALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELR 504
Query: 1243 -KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMV 1301
+ L+A +L+ + E + ++LE + RQ + + E+V
Sbjct: 505 QEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELV 564
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXX 1361
E+R Q E L K EA +L M +L+++ A L++
Sbjct: 565 EVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL----- 619
Query: 1362 XXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQ 1421
+K L+ L ++ L+R+ V + E + L+G+ + EQ
Sbjct: 620 -------------SKLSALNESLAQDKLDLNRL-------VAQLEEEKSALQGRQRQAEQ 659
Query: 1422 NSGAG---AKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
+ +R+ EL+ E E + LE SL + + E L + L E + +L
Sbjct: 660 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 719
Query: 1479 EKEQAQGELLHVQKELSTALGEIKTLQ------EKLGTESAAWNTEKTEMQNSIASLQER 1532
Q G +++ A +++ L+ E L E A + + +L E
Sbjct: 720 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 779
Query: 1533 LCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDY-ERVS 1591
+E+ L L + +R+L RR+ LE +++
Sbjct: 780 --ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQII 837
Query: 1592 KIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQV 1651
Q + S + ++A + R + + EL++ Q+
Sbjct: 838 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL 897
Query: 1652 -SRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
S+ +RE++ LEA ++ ++E + + R+ E E + ++L E +
Sbjct: 898 QSQLQREQEELLARLEAEKEELSE---EIAALQQERDEGLLLAESEKQQALSLKESEKTA 954
Query: 1711 LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGL-AT 1768
L ++L +R + ++ E+ +K A+ R + +S +N E R L + R A A
Sbjct: 955 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1014
Query: 1769 RMELAWHKERD---EQQRLLQETSTLARDLR 1796
+ + RD ++ L+E L LR
Sbjct: 1015 EVRRLQEQARDLGKQRDSCLREAEELRTQLR 1045
Score = 48.0 bits (109), Expect = 3e-04
Identities = 102/531 (19%), Positives = 221/531 (41%), Gaps = 50/531 (9%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
Q++ ++LR + L +++ E+E+E R S ++ RQ+++ A+ +E
Sbjct: 1397 QELRSAQRERDELRTQTSALNRQLAEMEAE---RDSATSRARQLQKAVAE---SEEARRS 1450
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ ++ EL L + R D+ ++L R L+ T R K+ K +
Sbjct: 1451 VDGRLSGVQAELA-LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1509
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+LE +K ++L E++ + ++ E + + LE E+ RS L L A+A +
Sbjct: 1510 NETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRS---RLGLSDREAQAQA 1562
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
SL + +V+ S + G Q +L L E E LR+++R E
Sbjct: 1563 -LQDRVDSLQR-------QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1614
Query: 562 ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + DK + +T H+ + + + + AA S+ + S L
Sbjct: 1615 ALAQ-SSASLNSTRDKNLHLQKALTACEHDRQ-----VLQERLDAARQALSEARKQSSSL 1668
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
T + DL + LR+ + +E + L ++K+ + R +
Sbjct: 1669 GEQVQTLRGEV-ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ-- 1725
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
S++ A E E E + + ++L E++ LRR ++++E++K +
Sbjct: 1726 ----ERLGSLQRALAQLEAEKREVERSALRL-----EKDRVALRRTLDKVEREKLRSHED 1776
Query: 742 VKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE 801
L+++ + +T G+ + + E +V VLE + +E + +
Sbjct: 1777 TVRLSAEKGRLDRTLTGAELELAEA--QRQIQQLEAQVVVLEQSHSPAQ---LEVDAQQQ 1831
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
+L + + + + R+L+A ++ + +++++ +E++ S L+ + Q
Sbjct: 1832 QLELQQEVERLRSAQAQTERTLEARERAH---RQRVRGLEEQVSTLKGQLQ 1879
Score = 46.4 bits (105), Expect = 0.001
Identities = 96/425 (22%), Positives = 168/425 (39%), Gaps = 44/425 (10%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSA 757
+ DP ++ L QE +R+ +EL AL +Q+ E+ ++ S T + +
Sbjct: 1382 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 1441
Query: 758 GSNTTARRSLTTNSN------KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ ARRS+ + L EE V+ E E ++ ER + +EL +Q
Sbjct: 1442 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1501
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK----LQTENKK 867
+K + + + D++ LK L E L + +SLE + ++ L +
Sbjct: 1502 EKISKMKANETKLEGDKRR--LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ 1559
Query: 868 LQLLKNAKSLRSDKALDLNTKK-TTQLENE-LKEALAKIKELEMICQDEKSEKKVR-FTE 924
Q L++ + D K T QL E L ALAK++E E +D KVR TE
Sbjct: 1560 AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD-----KVRGLTE 1614
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
A + + +L S + Q L DA + K+ + L
Sbjct: 1615 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL-----DAARQALSEARKQSSSLG 1669
Query: 985 TKLQ-LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
++Q L+ V DLE ++ G+ + L ++ E + + +
Sbjct: 1670 EQVQTLRGEVADLE---------LQRVEAEGQLQQLREVL-RQRQEGEAAALNTVQKLQD 1719
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC-KTLTEEMKNREAQIN 1102
E+ LQ + L+ A+LE +K LE + L K E++++ E +
Sbjct: 1720 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV- 1778
Query: 1103 KLSAD 1107
+LSA+
Sbjct: 1779 RLSAE 1783
Score = 42.3 bits (95), Expect = 0.017
Identities = 82/412 (19%), Positives = 171/412 (41%), Gaps = 29/412 (7%)
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
D++ + L+ TE+E A++ +++++K++ KLE + E + +
Sbjct: 1481 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1540
Query: 1379 ELDTDLQSERKKL-DR---MRIAHDK--DVKNKDAELATLKGKLKI-LEQNSGAGAKRIT 1431
L+ +LQ R L DR + D+ ++ + A+ G L++ +E+ +GA AK +
Sbjct: 1541 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAK-VE 1599
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK--ARLTVEKEQAQGELLH 1489
E + + V+ L +LA A K L++ + ++ E+ A + L
Sbjct: 1600 ESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALS 1659
Query: 1490 VQKELSTALGE-IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR 1548
++ S++LGE ++TL+ E A ++ E + + L+E L E E A LN
Sbjct: 1660 EARKQSSSLGEQVQTLR----GEVADLELQRVEAEGQLQQLREVL-RQRQEGEAAALNT- 1713
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVS-KIQRXXXXXXXXXXXX 1607
++ D R +L+ + ER + ++++
Sbjct: 1714 -------VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKV 1766
Query: 1608 XXXXXXXIEQSEK--ARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQML 1665
E + + A K + T T E ++ + +++ L QV + + +
Sbjct: 1767 EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEV 1826
Query: 1666 EAAQKSMAEIKNGD--KSARIHRNSISSTDEEEYRNKVALLEQQVACLEDEL 1715
+A Q+ + + + +SA+ E +R +V LE+QV+ L+ +L
Sbjct: 1827 DAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1878
Score = 33.9 bits (74), Expect = 6.0
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 18/174 (10%)
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSIS---ST 1692
+ + +R + +L+ Q++ ERD+ QK++AE + +S + + +
Sbjct: 1405 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 1464
Query: 1693 DEEEY----RNKVALLEQQVACLEDEL--CESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
EE R + A L+ QVA LE L ES L AS+ E +S+ + E +L + R
Sbjct: 1465 QEESVRRSERERRATLD-QVATLERSLQATESELRASQ---EKISKMKANETKLEGDKRR 1520
Query: 1747 LNEY---EEERL--LSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
L E E R L R + G R L + Q L +L R +
Sbjct: 1521 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1574
>AL365436-2|CAI16590.1| 1203|Homo sapiens cingulin protein.
Length = 1203
Score = 79.4 bits (187), Expect = 1e-13
Identities = 159/674 (23%), Positives = 274/674 (40%), Gaps = 68/674 (10%)
Query: 267 KEYQDQIEGLKQEV-DILRKRCE-RVEKEKSDILLRRLANIDTANKYTTG-------RSS 317
++YQ E L++ + D + E++K L+R L TG ++
Sbjct: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
Query: 318 EVLKL-QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
E L+ +Q++ +L E++ +E L +KI ++ ELE ++ TRQ+E L+ +LL
Sbjct: 580 EDLRATKQELLQLRMEKEEMEEE---LGEKIEVLQRELEQARASAGDTRQVEVLKKELLR 636
Query: 377 AETLCEELMDENEDMK-------KELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
+ +EL E + + +EL D RE + ++ L++ L+Q +
Sbjct: 637 TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELE-EQNLQLQKTLQQLRQ 695
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-----ENRIKELEQEVAR 484
+C S E +A L Q +A E L E D +R E ++KE V
Sbjct: 696 DCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDG 755
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR---- 540
V RL+ +L ++ +L + E + +E L R
Sbjct: 756 GEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQE 815
Query: 541 --DLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
L +LE E RE LR + E K++ LD+ V N I E
Sbjct: 816 QQTLNRALEEEGKQREVLRRGKAELEEQKRL-----LDRTVDRLNKELEKIGEDSKQALQ 870
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLS-----IFNHMAANNLRKT 653
+ + +E +D+ + D +E + L L + + A+ +
Sbjct: 871 QLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERD 930
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKL 712
AR+ D E L +L+ + +A ++K S A +L +E E E DE L
Sbjct: 931 TARL--DKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELL 988
Query: 713 LLELN------EQEATVL---RRKVEELEQDKEALKKQVKELTSKISS---VTKTSAGSN 760
+N +Q T L R ++LE DK +L++Q K+L ++++S K SA +
Sbjct: 989 TDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLS 1048
Query: 761 TTARRSLTTNSNKLAEERVK-VLEDEIDEVRKKLIEK--ERDCERLHA-----ELSLAQK 812
++ AEER K VL+ ++ +K+ E + + ER H +LSL K
Sbjct: 1049 QLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVK 1108
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA--SVLRAKTQSLEADNEKLQTENKKLQL 870
K + + + K Q +V EQ L+A+ +SLE D+ + + +
Sbjct: 1109 ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESA 1168
Query: 871 LKNAKSLRSDKALD 884
LKN + L SD+ D
Sbjct: 1169 LKN-EGLSSDEEFD 1181
Score = 61.3 bits (142), Expect = 3e-08
Identities = 157/859 (18%), Positives = 338/859 (39%), Gaps = 52/859 (6%)
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
++ +AT+ E + + +++++V + K+ + S+GS T A + K+
Sbjct: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGS-TKAVAGQGELTRKV- 368
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
EE + L++E+ + R+KL + ER E + + + L++ R +A Q N +L+
Sbjct: 369 EELQRKLDEEVKK-RQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQ-QSNKELQN 426
Query: 836 QLQVIEQEASVLRA-KTQSLEADNEKLQT---ENKKLQLLKNAKSLRS--DKALDLNTKK 889
++++Q + +TQ +E N+ E K LLK+ R ++ L+ +
Sbjct: 427 MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 486
Query: 890 TTQL---ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK-SKQXXXXXXXX 945
QL E EL +KE E+ +D++ E VR + +++T+ L+ S Q
Sbjct: 487 EEQLRLRERELTALKGALKE-EVASRDQEVEH-VR--QQYQRDTEQLRRSMQDATQDHAV 542
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQKS--FKPRIPKKPTDL-TTK---LQLKKMVEDLECE 999
+ + L++ ++++ ++ K DL TK LQL+ E++E E
Sbjct: 543 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 602
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+GE V++ + T+ +++ ++ +L + E + Q++ + +
Sbjct: 603 LGEKIEVLQRELEQARASAGDTR---QVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
Query: 1060 AKLEGDKDVF---ANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE V A++ + LE +N L + L ++ + EA K+ A+ + AT L
Sbjct: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCE--EASKAKMVAEAE-ATVLGQ 716
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ Q+ + + + DK +++
Sbjct: 717 RRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
Query: 1177 XXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQAR 1236
+ E L+ K + + T R E +++ L+
Sbjct: 777 LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRG 836
Query: 1237 FIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS 1296
+ E + L+ + L + E + + ++ ++ R+ D +A
Sbjct: 837 KAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKD 896
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXX 1356
E QDE+ + L+ ++AE A+L+ L L LE
Sbjct: 897 WASEAEK------TSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEA 950
Query: 1357 XXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKL 1416
E K L+T+L E+ ++ + D+ + +D ++ L+ +L
Sbjct: 951 ENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE---LLTDRVNRGRD-QVDQLRTEL 1006
Query: 1417 KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL 1476
+++ S ++ E + K L+ LA + +++ + LE ++ + + RL
Sbjct: 1007 --MQERSARQDLECDKISLERQN--KDLKTRLASSEG-FQKPSASLSQLESQNQLLQERL 1061
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGG 1536
E E+ + L ++L ++K L ++ E N +K ++ + +L+ ++
Sbjct: 1062 QAE-EREKTVLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA 1117
Query: 1537 GWEVERARLNARLDQRERE 1555
E+ER + QRE E
Sbjct: 1118 EEEIERLDGLRKKAQREVE 1136
Score = 53.2 bits (122), Expect = 9e-06
Identities = 122/680 (17%), Positives = 274/680 (40%), Gaps = 41/680 (6%)
Query: 265 NVKEYQDQIE----GLKQEVDILRKRCERVE--KEKSDILLRRLANI-DTANKYTTGRSS 317
N+K DQ E GL+ +V L+ + + V+ + ++LL+ L + + G+
Sbjct: 426 NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQR 485
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
+L+ + ELT L++E Q++ + + + TE R ++
Sbjct: 486 VEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQR--DTEQLRRSMQDATQDHAVL 543
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
E +++ +++EL + Q F++++ D + ++EL Q + +
Sbjct: 544 EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED-LRATKQELLQLRMEKEEMEEE 602
Query: 438 L-KKTERKADQLEQEKAEH-EKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
L +K E +LEQ +A + + +E++ + ++ + +KEL+ E +S EVA R +
Sbjct: 603 LGEKIEVLQRELEQARASAGDTRQVEVLK-KELLRTQEELKELQAE-RQSQEVAGRHRDR 660
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRS--SLTRGGSQEDPAQLLRDLQDSL--EREAD 551
E + + + +++ ++ L + + A+++ + + ++ +R A
Sbjct: 661 ELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAA 720
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVM-TDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+ LR +EE ++ L++Q+ T +V + + +Q
Sbjct: 721 VETTLRETQEENDEFRR--RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLE 778
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ S S+ + + + + A EE + +L+ K
Sbjct: 779 EALNASQEEEGSLAAAKRALEARLEEAQRGLAR-LGQEQQTLNRALEEEGKQREVLRRGK 837
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ + R L T +E + D K+ + A+++ E +E +R+ ++
Sbjct: 838 AELEEQKRLLDRTVDRLNKELEKIGE-DSKQALQQLQAQLEDYKEKARREVADAQRQAKD 896
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
+ E + L +I + + S A R +L +R++ LE E + +
Sbjct: 897 WASEAEKTSGGLSRLQDEIQRLRQALQASQ--AERDTARLDKELLAQRLQGLEQEAENKK 954
Query: 791 KKLIEKERDCE-------RLHAELSLAQKKPKTLIK--SRSLDASDQQNVDLKRQL---Q 838
+ ++ R + RL EL + + L +R D DQ +L ++ Q
Sbjct: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1014
Query: 839 VIEQEASVLRAKTQSLE---ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+E + L + + L+ A +E Q + L L++ L ++ L ++ T L++
Sbjct: 1015 DLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQER-LQAEEREKTVLQS 1073
Query: 896 ELKEALAKIKELEMICQDEK 915
++ K+KEL + +DE+
Sbjct: 1074 TNRKLERKVKELSIQIEDER 1093
Score = 52.0 bits (119), Expect = 2e-05
Identities = 91/431 (21%), Positives = 170/431 (39%), Gaps = 29/431 (6%)
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNS---GAGAKRI 1430
E+ ++ D + R+ + H + A ++G + LE+ S G
Sbjct: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMF 575
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEELTG-KYELLEEEHVVTKARLTVEKEQAQGELLH 1489
+ K++ T ++L L +EK E EE G K E+L+ E + +AR + + Q E+L
Sbjct: 576 QKNKEDLRATKQELLQ-LRMEKEEMEEELGEKIEVLQRE--LEQARASAG-DTRQVEVL- 630
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+KEL E+K LQ + ++ A E++ +A L+ E G E + +L
Sbjct: 631 -KKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKT 689
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q ++ A+ + V E R ++ +
Sbjct: 690 LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTL----RETQEENDEFRRRILGLEQQ 745
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ +A +A + D R E + + + L + + + + LE A
Sbjct: 746 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
Q+ +A + G + ++R + +EE + +V L + A LE++ +LN E
Sbjct: 806 QRGLARL--GQEQQTLNR----ALEEEGKQREV--LRRGKAELEEQKRLLDRTVDRLNKE 857
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQET 1788
L ++ L ++Q++L +Y+E+ R VA A R W E ++ L
Sbjct: 858 LEKIGEDSKQALQQLQAQLEDYKEK-----ARREVAD-AQRQAKDWASEAEKTSGGLSRL 911
Query: 1789 STLARDLRQTL 1799
+ LRQ L
Sbjct: 912 QDEIQRLRQAL 922
Score = 48.8 bits (111), Expect = 2e-04
Identities = 149/826 (18%), Positives = 316/826 (38%), Gaps = 67/826 (8%)
Query: 335 DLRDEKKHLTQKI-REIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKK 393
+L + + L +K+ E++ + PS RQ+E+ + + L E E + K
Sbjct: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
Query: 394 ELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ---- 447
EL+++ +D + E Q E + + ++ VL L +T ++
Sbjct: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
Query: 448 ---LEQEKAEHEKKLLEIVGG--PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSK 502
+E++ E++L + G + R+ ++ + Q+ R TE R ++ + ++
Sbjct: 483 KQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAV 542
Query: 503 FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
+ + + ++ +S G Q + DL+ + + LR + EEE
Sbjct: 543 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 602
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+V L +++ D + E + + + ++ +
Sbjct: 603 LGEKIEV-----LQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRH 657
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEEDNESLLLQLKKMATKARSRKL 680
D+ E+ Q + N L+KT ++ +D E KM +A + L
Sbjct: 658 RDRELEK-QLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE--ASKAKMVAEAEATVL 714
Query: 681 SPTPPANKLSI-ETANDNDEKETD----EADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
A + ++ ET +NDE E E + L++ E LR K++ LE +K
Sbjct: 715 GQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEK 774
Query: 736 EALKKQV---KELTSKISSVTKTSAGSNTTARRSLT------TNSNKLAEERVK---VLE 783
+ L++ + +E +++ + A+R L N+ EE K VL
Sbjct: 775 QQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
E+ ++ +R +RL+ EL + K ++ D + +R++ +++
Sbjct: 835 RGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKE-KARREVADAQRQ 893
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAK-----SLRSDKAL----------DLNTK 888
A ++ + +LQ E ++L+ A + R DK L + K
Sbjct: 894 AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENK 953
Query: 889 KTTQLE--NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
K +Q + +LK K+ LE +EK+ ++ T+ + D + +
Sbjct: 954 KRSQDDRARQLKGLEEKVSRLETELDEEKNTVEL-LTDRVNRGRDQVDQLRTELMQERSA 1012
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKP-TDLTTKLQLKKMVEDLECEIGEMYV 1005
+ K LK S + P + L ++ QL + E L+ E E V
Sbjct: 1013 RQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL--LQERLQAEEREKTV 1070
Query: 1006 VMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ + +++ K K L +I++ R ++ + + L+ ++ + ++ +L+G
Sbjct: 1071 LQS----TNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDG 1126
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
+ + + N L + K+L E+ R+A + + LKN
Sbjct: 1127 LRKKAQREVEEQHEVNEQLQARIKSL-EKDSWRKASRSAAESALKN 1171
Score = 48.4 bits (110), Expect = 3e-04
Identities = 103/563 (18%), Positives = 216/563 (38%), Gaps = 53/563 (9%)
Query: 1239 KTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK-YDEATSP 1297
+ E + E E+ LK + ++ S + + ++ + LR++ D D A
Sbjct: 485 RVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLE 544
Query: 1298 VEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXX 1357
E +M +E + + +K + + A K E+ QL+ + ++E
Sbjct: 545 AERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG 604
Query: 1358 XXXXXXXXXX--XXSSYWENKAKE-LDTDL---QSERKKLDRMRIAHDKDVKNKDAELAT 1411
+S + + E L +L Q E K+L R + + +++D EL
Sbjct: 605 EKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEK 664
Query: 1412 LKGKLKI-------LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
L++ LE+ + K + +L+Q+ EE K + + +AE L +
Sbjct: 665 QLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK----AKMVAEAEATVLGQRRAA 720
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEI---KTLQEKLGTESAAWNTEKTE 1521
+E T E ++ + +L ++++L G + + ++ +L + EK +
Sbjct: 721 VE----TTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
++ ++ + QE G + L ARL++ +R L + L +
Sbjct: 777 LEEALNASQEE--EGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834
Query: 1582 XXXXDYER--------VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTK--- 1630
+ E V ++ + +E ++ + E+ D +
Sbjct: 835 RGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQA 894
Query: 1631 -------TRYEGQMNTMRDELKSLHNQVSRFRRERDNY---KQML-EAAQKSMAEIKNGD 1679
+ G ++ ++DE++ L + + ERD K++L + Q E +N
Sbjct: 895 KDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKK 954
Query: 1680 KSARIHRNSISSTDEEEYRNKVALLEQQ--VACLEDELCESRLLASKLNTELVSEKSSAE 1737
+S + +E+ R + L E++ V L D + R +L TEL+ E+S+ +
Sbjct: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1014
Query: 1738 VRLAEMQS--RLNEYEEERLLSS 1758
+ S R N+ + RL SS
Sbjct: 1015 DLECDKISLERQNKDLKTRLASS 1037
Score = 42.3 bits (95), Expect = 0.017
Identities = 100/477 (20%), Positives = 184/477 (38%), Gaps = 32/477 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ +KE + ++G + LR + +R+E EK L N + + +
Sbjct: 742 LEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ--LEEALNASQEEEGSLAAAKRA-- 797
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L+ ++ E L E++ L + + E + E +A+ EQ R + L
Sbjct: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE--EQKRLLDRTVDRLN 855
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+EL ED K+ L+ L ++ R + AD + + K LS +
Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+R L+ +AE + L D R++ LEQE R+L
Sbjct: 916 QRLRQALQASQAERDTARL------DKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEE 969
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLEREAD---LREQL 556
K + L + + TV++ + RG Q D +L+++ + E D L Q
Sbjct: 970 KVSRLETELDE--EKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN 1027
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE----TVTNSIQNKMIHAASTPSS 612
++ + A+ + P+ Q+ + N + + ++E TV S K+ S
Sbjct: 1028 KDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSI 1087
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNH--MAANNLRKTAAR-VEED---NESLLL 666
+ + + ++ K + + + LRK A R VEE NE L
Sbjct: 1088 QIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQA 1147
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM-KLLLELNEQEAT 722
++K + K RK S + + L E + +DE+ DP+ + LL E N Q ++
Sbjct: 1148 RIKSL-EKDSWRKASRSAAESALKNEGLS-SDEEFDSVYDPSSIASLLTESNLQTSS 1202
>AL049569-4|CAI20365.1| 1898|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 1898
Score = 79.4 bits (187), Expect = 1e-13
Identities = 243/1295 (18%), Positives = 491/1295 (37%), Gaps = 88/1295 (6%)
Query: 292 KEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT-HNEDLRDEKKHLTQKIREI 350
+E++ +L + L+ ++ + E+ V+E T H++DL + IR
Sbjct: 51 QEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERDTEHSQDLE------SALIRLE 104
Query: 351 ESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDM---KKELRDLXXXXXXMQD 407
E + + + EQL A + L E++ D +KEL ++
Sbjct: 105 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEE 164
Query: 408 NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEI-VGGP 466
+F ++E+S L Q + R++S TER QL E A + + E +G
Sbjct: 165 SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLS 224
Query: 467 DGMQ-RENRIKE-LEQEVARSTEVALRLQ-RELAEANSKFTGSNPSLMKVPQPETVKVSR 523
G++ E+R + LE++ ++ +L+ + L E + L K V
Sbjct: 225 TGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELG 284
Query: 524 SSLTRGGSQE-DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTD 582
++ R Q + Q+ +DL + LE LR Q + A E L + V++D
Sbjct: 285 LAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSD 344
Query: 583 NIVTCDIHESETVTNSIQNKM--IHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLS 640
+ + SE ++ + + TPS +S SP + D L+
Sbjct: 345 SESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRS-SPGRGRSPRRGPSPACSDSSTLA 403
Query: 641 IFN---HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDN 697
+ + H ++ R E ++ LL L+K + + S + + +L +T
Sbjct: 404 LIHSALHKRQLQVQDMRGRYEA-SQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM 462
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
E + + ++ EL +E + L ++ +Q E L+++ ++L +
Sbjct: 463 QAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQA---------- 512
Query: 758 GSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTL 817
A+ L ++L EE+ ++D VR++L R E+L + S+ K+ +
Sbjct: 513 -----AQEELRRQRDRLEEEQEDAVQDGA-RVRRELERSHRQLEQLEGKRSVLAKELVEV 566
Query: 818 IKSRSL-----DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
++ S D + ++ L E L L A+ LQ KL L
Sbjct: 567 REALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALN 626
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+SL DK LDLN + QLE E + ++ E + E++ R E ++
Sbjct: 627 --ESLAQDK-LDLN-RLVAQLEEEKSALQGRQRQAEQEATVAREEQE-RLEELRLEQEVA 681
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
+ + + L++ + + ++ + + ++
Sbjct: 682 RQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQ 741
Query: 993 VEDLECEIGEMYVVMK-NAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
VE LE E + K +AGL+ ++ A + + + E ++L +Q +
Sbjct: 742 VEALERAAREKEALAKEHAGLA-VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQ 800
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK-NREAQINKL-SADLK 1109
+A+L+ +LE + + L E + L Q E+ ++E KL A+ +
Sbjct: 801 LAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAERE 860
Query: 1110 NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKK 1169
SL+ + Q+ + ++ +++ +LL + + ++
Sbjct: 861 AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQS--QLQREQEELLARLEAEKEE 918
Query: 1170 IGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSE 1229
+ + + + S ++ ++ + + ++ +S+E+ +
Sbjct: 919 LSEEIAALQQERDEGLLLAE--SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQ 976
Query: 1230 KDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
K + Q+R + S L +E+RDL+A E AA +++L++ R
Sbjct: 977 KRDAQSRQEQDRSTVNALTSELRDLRA-------QREEAAAAHAQEVRRLQEQARDLGKQ 1029
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
+ D E E+R + EL A+ KL +++ + E +L+ L
Sbjct: 1030 R-DSCLREAE--ELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSL 1086
Query: 1350 AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL 1409
E S+ + +++ + L +E K+ + + K+A
Sbjct: 1087 G--EGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEA-- 1142
Query: 1410 ATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLE--- 1466
L+ L+ +E++ + + EL+++ +K L+ E EL G+ L E
Sbjct: 1143 GELRTGLQEVERSRLEARRELQELRRQ----MKMLDSENTRLGRELAELQGRLALGERAE 1198
Query: 1467 ----EEHVVTKARL---TVEKEQAQGELLHVQKELSTALGEIKTLQEK-LGTESAAWNTE 1518
E + + RL E + EL Q++L GE +T + + LG+ A TE
Sbjct: 1199 KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTE 1258
Query: 1519 KTEMQNSIASLQERLCGGGWEVERARLNARLDQRE 1553
K ++ ++ L+ +L E A L RL E
Sbjct: 1259 KQQLDHA-RGLELKLEAA--RAEAAELGLRLSAAE 1290
Score = 68.5 bits (160), Expect = 2e-10
Identities = 136/703 (19%), Positives = 276/703 (39%), Gaps = 54/703 (7%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTG 314
+ +E + + E L+ + LR++ +R+E+E+ D + R L + G
Sbjct: 495 VAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEG 554
Query: 315 RSS----EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQ 369
+ S E++++++ ++ T + L+ EK + + + + E+ +E S +
Sbjct: 555 KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEAS 614
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
L+ L L E L + D+ + + L +Q R+ QA++ +++ RE ++ ++
Sbjct: 615 LQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQG--RQRQAEQEATVAREEQERLE 672
Query: 430 NCRV--------LSFKLKKTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELE 479
R+ L L+ E+ + LEQ+ HE+ L+ Q R +ELE
Sbjct: 673 ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 732
Query: 480 Q---EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA 536
Q E R E R RE + G L+ + G + + A
Sbjct: 733 QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER------------EGRTLSEEA 780
Query: 537 QLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETV 595
LR +++LE +++ QL E + L K+ +T + T
Sbjct: 781 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQ 840
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
+ +K + A ++ ++ + EE + + + A + +
Sbjct: 841 EKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER-AQLQS 899
Query: 656 RVEEDNESLL--LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+++ + E LL L+ +K L L E+ + A + L
Sbjct: 900 QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 959
Query: 714 LELNEQEATV---LRRKVEELEQDKEALKKQVKELTSKISSV---TKTSAGSNTTARRSL 767
+ AT+ + R+ + + +E + V LTS++ + + +A ++ R L
Sbjct: 960 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1019
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD 827
+ L ++R L E +E+R +L E + L EL AQ+K + + R +
Sbjct: 1020 QEQARDLGKQRDSCLR-EAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR--EVQR 1076
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL---KNAKSLRSDKALD 884
Q+ +L+R L +E LR + L + +K ++E L+L K K ++A
Sbjct: 1077 QEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART 1136
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
K+ +L L+E E Q+ + + K+ +E T+
Sbjct: 1137 AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTR 1179
Score = 64.5 bits (150), Expect = 4e-09
Identities = 130/638 (20%), Positives = 264/638 (41%), Gaps = 50/638 (7%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKI 347
E + ++K D L R +A ++ GR + + E E+LR E++ Q +
Sbjct: 627 ESLAQDKLD-LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGL 685
Query: 348 R-EIESELETRPSTEAQTRQIEQLRAKLLAA-ETLCEELMDENEDMKKELRDLXXXXXXM 405
+ + + + E Q + R++L L +L +++++ R+ +
Sbjct: 686 EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEAL 745
Query: 406 QDNFREDQA--DEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
+ RE +A E++ L +L + R LS + + + + LE E +++L ++
Sbjct: 746 ERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLE 805
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ ++ E + L +E LR Q+ +A K+ Q E +
Sbjct: 806 ARREQLEAEGQALLLAKETLTGELAGLR-QQIIATQEKASLDKELMAQKLVQAEREAQAS 864
Query: 524 SSLTRGGSQEDPAQLLRDLQDS---LERE-ADLREQLRNAEEET-----ANCKQVNPPTF 574
R +ED +L R+ + + LE E A L+ QL+ +EE A ++++
Sbjct: 865 LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIA 924
Query: 575 LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHF 634
+Q + ++ + + + ++ K + ++ + L +++ + Q
Sbjct: 925 ALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQ 984
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS---RKLSPTPPANKLS- 690
+ ++ + + LR A+ EE + +++++ +AR ++ S A +L
Sbjct: 985 EQDRSTV--NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRT 1042
Query: 691 ----IETANDNDEKETDEADPA--EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKE 744
+E A D +E EA E + E+ QEA LRR + E +++EAL++ +E
Sbjct: 1043 QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEE 1102
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDEIDEVRKKLIEKERDCER 802
L S + K + + + + KLA EE + E E+R L E ER R
Sbjct: 1103 LRSAV----KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER--SR 1156
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV-LRAKTQSLEADNEKL 861
L A L + + R + D +N L R+L ++ ++ RA+ +S +
Sbjct: 1157 LEARRELQELR-------RQMKMLDSENTRLGRELAELQGRLALGERAEKES------RR 1203
Query: 862 QTENKKLQLLKNAKSLR-SDKALDLNTKKTTQLENELK 898
+T + +LLK SL + L + +K + E E +
Sbjct: 1204 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1241
Score = 60.5 bits (140), Expect = 6e-08
Identities = 147/821 (17%), Positives = 320/821 (38%), Gaps = 68/821 (8%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E L++ + LR ++ E E+ + +LAN D K + + ++ EL T
Sbjct: 1094 EALRRSNEELRSAVKKAESERISL---KLANEDKEQKLALLEEARTA-VGKEAGELRTGL 1149
Query: 334 EDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELMDENEDMK 392
+++ + ++++E+ +++ S + R++ +L+ +L E +E E ++
Sbjct: 1150 QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR 1209
Query: 393 KELRDLXXXXXXMQDNFR------EDQADEYSSLRRELEQTIKNCRVLSFK----LKKTE 442
+ L M+ + ++Q E+ + R L +++ R + + E
Sbjct: 1210 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE 1269
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR--LQRELAEAN 500
K + E AE +L G G++ E E+++ A + LR L+R L
Sbjct: 1270 LKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGR 1329
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTR--------GGSQEDPAQLLRDLQDSLEREADL 552
+ P + + S L G P L+ EA +
Sbjct: 1330 APSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA-V 1388
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
R LR +E + ++ D+ + + + E E +S ++ A +
Sbjct: 1389 RGALREFLQELRSAQRER-----DELRTQTSALNRQLAEMEAERDSATSR---ARQLQKA 1440
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
+S+ S+D Q L S+ + R T +V SL Q +
Sbjct: 1441 VAESEEARRSVDGRLSGVQAELALQEESV--RRSERERRATLDQVATLERSL--QATESE 1496
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV--EE 730
+A K+S AN+ +E ++ D ++ +KL L+ E + R ++ +
Sbjct: 1497 LRASQEKISKMK-ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1555
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
E +AL+ +V L +++ ++ AG+ L K+ EE L D++ +
Sbjct: 1556 REAQAQALQDRVDSLQRQVAD-SEVKAGTLQLTVERLNGALAKV-EESEGALRDKVRGLT 1613
Query: 791 KKLIEKERDC-----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ L + + LH + +L + + LDA+ Q + ++Q + ++
Sbjct: 1614 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1673
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
LR + LE ++++ E + QL + + + +A LNT + Q E L + ++
Sbjct: 1674 TLRGEVADLEL--QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQE--RLG 1729
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
L+ ++EK+ A + E D + ++ + L+S +
Sbjct: 1730 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVE--------------REKLRSHE 1775
Query: 966 DDAQKSF-KPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
D + S K R+ + T +L + ++ ++ LE ++ + A L + +L
Sbjct: 1776 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL 1835
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
++E++ +RS ++ + + + + L++ + L+G
Sbjct: 1836 QQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1876
Score = 55.6 bits (128), Expect = 2e-06
Identities = 119/631 (18%), Positives = 233/631 (36%), Gaps = 49/631 (7%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTES-- 1242
+ +E+QL +D+ + L + + LS E ++ LQ + E
Sbjct: 445 RALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELR 504
Query: 1243 -KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMV 1301
+ L+A +L+ + E + ++LE + RQ + + E+V
Sbjct: 505 QEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELV 564
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXX 1361
E+R Q E L K EA +L M +L+++ A L++
Sbjct: 565 EVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL----- 619
Query: 1362 XXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQ 1421
+K L+ L ++ L+R+ V + E + L+G+ + EQ
Sbjct: 620 -------------SKLSALNESLAQDKLDLNRL-------VAQLEEEKSALQGRQRQAEQ 659
Query: 1422 NSGAG---AKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
+ +R+ EL+ E E + LE SL + + E L + L E + +L
Sbjct: 660 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 719
Query: 1479 EKEQAQGELLHVQKELSTALGEIKTLQ------EKLGTESAAWNTEKTEMQNSIASLQER 1532
Q G +++ A +++ L+ E L E A + + +L E
Sbjct: 720 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 779
Query: 1533 LCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDY-ERVS 1591
+E+ L L + +R+L RR+ LE +++
Sbjct: 780 --ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQII 837
Query: 1592 KIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQV 1651
Q + S + ++A + R + + EL++ Q+
Sbjct: 838 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL 897
Query: 1652 -SRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
S+ +RE++ LEA ++ ++E + + R+ E E + ++L E +
Sbjct: 898 QSQLQREQEELLARLEAEKEELSE---EIAALQQERDEGLLLAESEKQQALSLKESEKTA 954
Query: 1711 LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGL-AT 1768
L ++L +R + ++ E+ +K A+ R + +S +N E R L + R A A
Sbjct: 955 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1014
Query: 1769 RMELAWHKERD---EQQRLLQETSTLARDLR 1796
+ + RD ++ L+E L LR
Sbjct: 1015 EVRRLQEQARDLGKQRDSCLREAEELRTQLR 1045
Score = 48.0 bits (109), Expect = 3e-04
Identities = 102/531 (19%), Positives = 221/531 (41%), Gaps = 50/531 (9%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
Q++ ++LR + L +++ E+E+E R S ++ RQ+++ A+ +E
Sbjct: 1397 QELRSAQRERDELRTQTSALNRQLAEMEAE---RDSATSRARQLQKAVAE---SEEARRS 1450
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ ++ EL L + R D+ ++L R L+ T R K+ K +
Sbjct: 1451 VDGRLSGVQAELA-LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1509
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+LE +K ++L E++ + ++ E + + LE E+ RS L L A+A +
Sbjct: 1510 NETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRS---RLGLSDREAQAQA 1562
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
SL + +V+ S + G Q +L L E E LR+++R E
Sbjct: 1563 -LQDRVDSLQR-------QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1614
Query: 562 ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + DK + +T H+ + + + + AA S+ + S L
Sbjct: 1615 ALAQ-SSASLNSTRDKNLHLQKALTACEHDRQ-----VLQERLDAARQALSEARKQSSSL 1668
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
T + DL + LR+ + +E + L ++K+ + R +
Sbjct: 1669 GEQVQTLRGEV-ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ-- 1725
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
S++ A E E E + + ++L E++ LRR ++++E++K +
Sbjct: 1726 ----ERLGSLQRALAQLEAEKREVERSALRL-----EKDRVALRRTLDKVEREKLRSHED 1776
Query: 742 VKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE 801
L+++ + +T G+ + + E +V VLE + +E + +
Sbjct: 1777 TVRLSAEKGRLDRTLTGAELELAEA--QRQIQQLEAQVVVLEQSHSPAQ---LEVDAQQQ 1831
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
+L + + + + R+L+A ++ + +++++ +E++ S L+ + Q
Sbjct: 1832 QLELQQEVERLRSAQAQTERTLEARERAH---RQRVRGLEEQVSTLKGQLQ 1879
Score = 46.4 bits (105), Expect = 0.001
Identities = 96/425 (22%), Positives = 168/425 (39%), Gaps = 44/425 (10%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSA 757
+ DP ++ L QE +R+ +EL AL +Q+ E+ ++ S T + +
Sbjct: 1382 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 1441
Query: 758 GSNTTARRSLTTNSN------KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ ARRS+ + L EE V+ E E ++ ER + +EL +Q
Sbjct: 1442 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1501
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK----LQTENKK 867
+K + + + D++ LK L E L + +SLE + ++ L +
Sbjct: 1502 EKISKMKANETKLEGDKRR--LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ 1559
Query: 868 LQLLKNAKSLRSDKALDLNTKK-TTQLENE-LKEALAKIKELEMICQDEKSEKKVR-FTE 924
Q L++ + D K T QL E L ALAK++E E +D KVR TE
Sbjct: 1560 AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD-----KVRGLTE 1614
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
A + + +L S + Q L DA + K+ + L
Sbjct: 1615 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL-----DAARQALSEARKQSSSLG 1669
Query: 985 TKLQ-LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
++Q L+ V DLE ++ G+ + L ++ E + + +
Sbjct: 1670 EQVQTLRGEVADLE---------LQRVEAEGQLQQLREVL-RQRQEGEAAALNTVQKLQD 1719
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC-KTLTEEMKNREAQIN 1102
E+ LQ + L+ A+LE +K LE + L K E++++ E +
Sbjct: 1720 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV- 1778
Query: 1103 KLSAD 1107
+LSA+
Sbjct: 1779 RLSAE 1783
Score = 42.3 bits (95), Expect = 0.017
Identities = 82/412 (19%), Positives = 171/412 (41%), Gaps = 29/412 (7%)
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
D++ + L+ TE+E A++ +++++K++ KLE + E + +
Sbjct: 1481 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1540
Query: 1379 ELDTDLQSERKKL-DR---MRIAHDK--DVKNKDAELATLKGKLKI-LEQNSGAGAKRIT 1431
L+ +LQ R L DR + D+ ++ + A+ G L++ +E+ +GA AK +
Sbjct: 1541 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAK-VE 1599
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK--ARLTVEKEQAQGELLH 1489
E + + V+ L +LA A K L++ + ++ E+ A + L
Sbjct: 1600 ESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALS 1659
Query: 1490 VQKELSTALGE-IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR 1548
++ S++LGE ++TL+ E A ++ E + + L+E L E E A LN
Sbjct: 1660 EARKQSSSLGEQVQTLR----GEVADLELQRVEAEGQLQQLREVL-RQRQEGEAAALNT- 1713
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVS-KIQRXXXXXXXXXXXX 1607
++ D R +L+ + ER + ++++
Sbjct: 1714 -------VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKV 1766
Query: 1608 XXXXXXXIEQSEK--ARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQML 1665
E + + A K + T T E ++ + +++ L QV + + +
Sbjct: 1767 EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEV 1826
Query: 1666 EAAQKSMAEIKNGD--KSARIHRNSISSTDEEEYRNKVALLEQQVACLEDEL 1715
+A Q+ + + + +SA+ E +R +V LE+QV+ L+ +L
Sbjct: 1827 DAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1878
Score = 33.9 bits (74), Expect = 6.0
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 18/174 (10%)
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSIS---ST 1692
+ + +R + +L+ Q++ ERD+ QK++AE + +S + + +
Sbjct: 1405 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 1464
Query: 1693 DEEEY----RNKVALLEQQVACLEDEL--CESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
EE R + A L+ QVA LE L ES L AS+ E +S+ + E +L + R
Sbjct: 1465 QEESVRRSERERRATLD-QVATLERSLQATESELRASQ---EKISKMKANETKLEGDKRR 1520
Query: 1747 LNEY---EEERL--LSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
L E E R L R + G R L + Q L +L R +
Sbjct: 1521 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1574
>AF263462-1|AAF74498.1| 1203|Homo sapiens cingulin protein.
Length = 1203
Score = 79.4 bits (187), Expect = 1e-13
Identities = 159/674 (23%), Positives = 274/674 (40%), Gaps = 68/674 (10%)
Query: 267 KEYQDQIEGLKQEV-DILRKRCE-RVEKEKSDILLRRLANIDTANKYTTG-------RSS 317
++YQ E L++ + D + E++K L+R L TG ++
Sbjct: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
Query: 318 EVLKL-QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
E L+ +Q++ +L E++ +E L +KI ++ ELE ++ TRQ+E L+ +LL
Sbjct: 580 EDLRATKQELLQLRMEKEEMEEE---LGEKIEVLQRELEQARASAGDTRQVEVLKKELLR 636
Query: 377 AETLCEELMDENEDMK-------KELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
+ +EL E + + +EL D RE + ++ L++ L+Q +
Sbjct: 637 TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELE-EQNLQLQKTLQQLRQ 695
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-----ENRIKELEQEVAR 484
+C S E +A L Q +A E L E D +R E ++KE V
Sbjct: 696 DCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDG 755
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR---- 540
V RL+ +L ++ +L + E + +E L R
Sbjct: 756 GEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQE 815
Query: 541 --DLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
L +LE E RE LR + E K++ LD+ V N I E
Sbjct: 816 QQTLNRALEEEGKQREVLRRGKAELEEQKRL-----LDRTVDRLNKELEKIGEDSKQALQ 870
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLS-----IFNHMAANNLRKT 653
+ + +E +D+ + D +E + L L + + A+ +
Sbjct: 871 QLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERD 930
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKL 712
AR+ D E L +L+ + +A ++K S A +L +E E E DE L
Sbjct: 931 TARL--DKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELL 988
Query: 713 LLELN------EQEATVL---RRKVEELEQDKEALKKQVKELTSKISS---VTKTSAGSN 760
+N +Q T L R ++LE DK +L++Q K+L ++++S K SA +
Sbjct: 989 TDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLS 1048
Query: 761 TTARRSLTTNSNKLAEERVK-VLEDEIDEVRKKLIEK--ERDCERLHA-----ELSLAQK 812
++ AEER K VL+ ++ +K+ E + + ER H +LSL K
Sbjct: 1049 QLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVK 1108
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA--SVLRAKTQSLEADNEKLQTENKKLQL 870
K + + + K Q +V EQ L+A+ +SLE D+ + + +
Sbjct: 1109 ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESA 1168
Query: 871 LKNAKSLRSDKALD 884
LKN + L SD+ D
Sbjct: 1169 LKN-EGLSSDEEFD 1181
Score = 61.3 bits (142), Expect = 3e-08
Identities = 157/859 (18%), Positives = 338/859 (39%), Gaps = 52/859 (6%)
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
++ +AT+ E + + +++++V + K+ + S+GS T A + K+
Sbjct: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGS-TKAVAGQGELTRKV- 368
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
EE + L++E+ + R+KL + ER E + + + L++ R +A Q N +L+
Sbjct: 369 EELQRKLDEEVKK-RQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQ-QSNKELQN 426
Query: 836 QLQVIEQEASVLRA-KTQSLEADNEKLQT---ENKKLQLLKNAKSLRS--DKALDLNTKK 889
++++Q + +TQ +E N+ E K LLK+ R ++ L+ +
Sbjct: 427 MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 486
Query: 890 TTQL---ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK-SKQXXXXXXXX 945
QL E EL +KE E+ +D++ E VR + +++T+ L+ S Q
Sbjct: 487 EEQLRLRERELTALKGALKE-EVASRDQEVEH-VR--QQYQRDTEQLRRSMQDATQDHAV 542
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQKS--FKPRIPKKPTDL-TTK---LQLKKMVEDLECE 999
+ + L++ ++++ ++ K DL TK LQL+ E++E E
Sbjct: 543 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 602
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+GE V++ + T+ +++ ++ +L + E + Q++ + +
Sbjct: 603 LGEKIEVLQRELEQARASAGDTR---QVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
Query: 1060 AKLEGDKDVF---ANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE V A++ + LE +N L + L ++ + EA K+ A+ + AT L
Sbjct: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCE--EASKAKMVAEAE-ATVLGQ 716
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ Q+ + + + DK +++
Sbjct: 717 RRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
Query: 1177 XXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQAR 1236
+ E L+ K + + T R E +++ L+
Sbjct: 777 LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRG 836
Query: 1237 FIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS 1296
+ E + L+ + L + E + + ++ ++ R+ D +A
Sbjct: 837 KAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKD 896
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXX 1356
E QDE+ + L+ ++AE A+L+ L L LE
Sbjct: 897 WASEAEK------TSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEA 950
Query: 1357 XXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKL 1416
E K L+T+L E+ ++ + D+ + +D ++ L+ +L
Sbjct: 951 ENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE---LLTDRVNRGRD-QVDQLRTEL 1006
Query: 1417 KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL 1476
+++ S ++ E + K L+ LA + +++ + LE ++ + + RL
Sbjct: 1007 --MQERSARQDLECDKISLERQN--KDLKTRLASSEG-FQKPSASLSQLESQNQLLQERL 1061
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGG 1536
E E+ + L ++L ++K L ++ E N +K ++ + +L+ ++
Sbjct: 1062 QAE-EREKTVLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA 1117
Query: 1537 GWEVERARLNARLDQRERE 1555
E+ER + QRE E
Sbjct: 1118 EEEIERLDGLRKKAQREVE 1136
Score = 53.2 bits (122), Expect = 9e-06
Identities = 122/680 (17%), Positives = 274/680 (40%), Gaps = 41/680 (6%)
Query: 265 NVKEYQDQIE----GLKQEVDILRKRCERVE--KEKSDILLRRLANI-DTANKYTTGRSS 317
N+K DQ E GL+ +V L+ + + V+ + ++LL+ L + + G+
Sbjct: 426 NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQR 485
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
+L+ + ELT L++E Q++ + + + TE R ++
Sbjct: 486 VEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQR--DTEQLRRSMQDATQDHAVL 543
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
E +++ +++EL + Q F++++ D + ++EL Q + +
Sbjct: 544 EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED-LRATKQELLQLRMEKEEMEEE 602
Query: 438 L-KKTERKADQLEQEKAEH-EKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
L +K E +LEQ +A + + +E++ + ++ + +KEL+ E +S EVA R +
Sbjct: 603 LGEKIEVLQRELEQARASAGDTRQVEVLK-KELLRTQEELKELQAE-RQSQEVAGRHRDR 660
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRS--SLTRGGSQEDPAQLLRDLQDSL--EREAD 551
E + + + +++ ++ L + + A+++ + + ++ +R A
Sbjct: 661 ELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAA 720
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVM-TDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+ LR +EE ++ L++Q+ T +V + + +Q
Sbjct: 721 VETTLRETQEENDEFRR--RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLE 778
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ S S+ + + + + A EE + +L+ K
Sbjct: 779 EALNASQEEEGSLAAAKRALEARLEEAQRGLAR-LGQEQQTLNRALEEEGKQREVLRRGK 837
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ + R L T +E + D K+ + A+++ E +E +R+ ++
Sbjct: 838 AELEEQKRLLDRTVDRLNKELEKIGE-DSKQALQQLQAQLEDYKEKARREVADAQRQAKD 896
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
+ E + L +I + + S A R +L +R++ LE E + +
Sbjct: 897 WASEAEKTSGGLSRLQDEIQRLRQALQASQ--AERDTARLDKELLAQRLQGLEQEAENKK 954
Query: 791 KKLIEKERDCE-------RLHAELSLAQKKPKTLIK--SRSLDASDQQNVDLKRQL---Q 838
+ ++ R + RL EL + + L +R D DQ +L ++ Q
Sbjct: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1014
Query: 839 VIEQEASVLRAKTQSLE---ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+E + L + + L+ A +E Q + L L++ L ++ L ++ T L++
Sbjct: 1015 DLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQER-LQAEEREKTVLQS 1073
Query: 896 ELKEALAKIKELEMICQDEK 915
++ K+KEL + +DE+
Sbjct: 1074 TNRKLERKVKELSIQIEDER 1093
Score = 52.0 bits (119), Expect = 2e-05
Identities = 91/431 (21%), Positives = 170/431 (39%), Gaps = 29/431 (6%)
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNS---GAGAKRI 1430
E+ ++ D + R+ + H + A ++G + LE+ S G
Sbjct: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMF 575
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEELTG-KYELLEEEHVVTKARLTVEKEQAQGELLH 1489
+ K++ T ++L L +EK E EE G K E+L+ E + +AR + + Q E+L
Sbjct: 576 QKNKEDLRATKQELLQ-LRMEKEEMEEELGEKIEVLQRE--LEQARASAG-DTRQVEVL- 630
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+KEL E+K LQ + ++ A E++ +A L+ E G E + +L
Sbjct: 631 -KKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKT 689
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q ++ A+ + V E R ++ +
Sbjct: 690 LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTL----RETQEENDEFRRRILGLEQQ 745
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ +A +A + D R E + + + L + + + + LE A
Sbjct: 746 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
Q+ +A + G + ++R + +EE + +V L + A LE++ +LN E
Sbjct: 806 QRGLARL--GQEQQTLNR----ALEEEGKQREV--LRRGKAELEEQKRLLDRTVDRLNKE 857
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQET 1788
L ++ L ++Q++L +Y+E+ R VA A R W E ++ L
Sbjct: 858 LEKIGEDSKQALQQLQAQLEDYKEK-----ARREVAD-AQRQAKDWASEAEKTSGGLSRL 911
Query: 1789 STLARDLRQTL 1799
+ LRQ L
Sbjct: 912 QDEIQRLRQAL 922
Score = 48.8 bits (111), Expect = 2e-04
Identities = 149/826 (18%), Positives = 316/826 (38%), Gaps = 67/826 (8%)
Query: 335 DLRDEKKHLTQKI-REIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKK 393
+L + + L +K+ E++ + PS RQ+E+ + + L E E + K
Sbjct: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
Query: 394 ELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ---- 447
EL+++ +D + E Q E + + ++ VL L +T ++
Sbjct: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
Query: 448 ---LEQEKAEHEKKLLEIVGG--PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSK 502
+E++ E++L + G + R+ ++ + Q+ R TE R ++ + ++
Sbjct: 483 KQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAV 542
Query: 503 FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
+ + + ++ +S G Q + DL+ + + LR + EEE
Sbjct: 543 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 602
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+V L +++ D + E + + + ++ +
Sbjct: 603 LGEKIEV-----LQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRH 657
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEEDNESLLLQLKKMATKARSRKL 680
D+ E+ Q + N L+KT ++ +D E KM +A + L
Sbjct: 658 RDRELEK-QLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE--ASKAKMVAEAEATVL 714
Query: 681 SPTPPANKLSI-ETANDNDEKETD----EADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
A + ++ ET +NDE E E + L++ E LR K++ LE +K
Sbjct: 715 GQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEK 774
Query: 736 EALKKQV---KELTSKISSVTKTSAGSNTTARRSLT------TNSNKLAEERVK---VLE 783
+ L++ + +E +++ + A+R L N+ EE K VL
Sbjct: 775 QQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
E+ ++ +R +RL+ EL + K ++ D + +R++ +++
Sbjct: 835 RGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKE-KARREVADAQRQ 893
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAK-----SLRSDKAL----------DLNTK 888
A ++ + +LQ E ++L+ A + R DK L + K
Sbjct: 894 AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENK 953
Query: 889 KTTQLE--NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
K +Q + +LK K+ LE +EK+ ++ T+ + D + +
Sbjct: 954 KRSQDDRARQLKGLEEKVSRLETELDEEKNTVEL-LTDRVNRGRDQVDQLRTELMQERSA 1012
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKP-TDLTTKLQLKKMVEDLECEIGEMYV 1005
+ K LK S + P + L ++ QL + E L+ E E V
Sbjct: 1013 RQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL--LQERLQAEEREKTV 1070
Query: 1006 VMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ + +++ K K L +I++ R ++ + + L+ ++ + ++ +L+G
Sbjct: 1071 LQS----TNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDG 1126
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
+ + + N L + K+L E+ R+A + + LKN
Sbjct: 1127 LRKKAQREVEEQHEVNEQLQARIKSL-EKDSWRKASRSAAESALKN 1171
Score = 48.4 bits (110), Expect = 3e-04
Identities = 103/563 (18%), Positives = 216/563 (38%), Gaps = 53/563 (9%)
Query: 1239 KTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK-YDEATSP 1297
+ E + E E+ LK + ++ S + + ++ + LR++ D D A
Sbjct: 485 RVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLE 544
Query: 1298 VEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXX 1357
E +M +E + + +K + + A K E+ QL+ + ++E
Sbjct: 545 AERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG 604
Query: 1358 XXXXXXXXXX--XXSSYWENKAKE-LDTDL---QSERKKLDRMRIAHDKDVKNKDAELAT 1411
+S + + E L +L Q E K+L R + + +++D EL
Sbjct: 605 EKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEK 664
Query: 1412 LKGKLKI-------LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
L++ LE+ + K + +L+Q+ EE K + + +AE L +
Sbjct: 665 QLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK----AKMVAEAEATVLGQRRAA 720
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEI---KTLQEKLGTESAAWNTEKTE 1521
+E T E ++ + +L ++++L G + + ++ +L + EK +
Sbjct: 721 VE----TTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
++ ++ + QE G + L ARL++ +R L + L +
Sbjct: 777 LEEALNASQEE--EGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834
Query: 1582 XXXXDYER--------VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTK--- 1630
+ E V ++ + +E ++ + E+ D +
Sbjct: 835 RGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQA 894
Query: 1631 -------TRYEGQMNTMRDELKSLHNQVSRFRRERDNY---KQML-EAAQKSMAEIKNGD 1679
+ G ++ ++DE++ L + + ERD K++L + Q E +N
Sbjct: 895 KDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKK 954
Query: 1680 KSARIHRNSISSTDEEEYRNKVALLEQQ--VACLEDELCESRLLASKLNTELVSEKSSAE 1737
+S + +E+ R + L E++ V L D + R +L TEL+ E+S+ +
Sbjct: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1014
Query: 1738 VRLAEMQS--RLNEYEEERLLSS 1758
+ S R N+ + RL SS
Sbjct: 1015 DLECDKISLERQNKDLKTRLASS 1037
Score = 42.3 bits (95), Expect = 0.017
Identities = 100/477 (20%), Positives = 184/477 (38%), Gaps = 32/477 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ +KE + ++G + LR + +R+E EK L N + + +
Sbjct: 742 LEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ--LEEALNASQEEEGSLAAAKRA-- 797
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L+ ++ E L E++ L + + E + E +A+ EQ R + L
Sbjct: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE--EQKRLLDRTVDRLN 855
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+EL ED K+ L+ L ++ R + AD + + K LS +
Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+R L+ +AE + L D R++ LEQE R+L
Sbjct: 916 QRLRQALQASQAERDTARL------DKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEE 969
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLEREAD---LREQL 556
K + L + + TV++ + RG Q D +L+++ + E D L Q
Sbjct: 970 KVSRLETELDE--EKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN 1027
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE----TVTNSIQNKMIHAASTPSS 612
++ + A+ + P+ Q+ + N + + ++E TV S K+ S
Sbjct: 1028 KDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSI 1087
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNH--MAANNLRKTAAR-VEED---NESLLL 666
+ + + ++ K + + + LRK A R VEE NE L
Sbjct: 1088 QIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQA 1147
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM-KLLLELNEQEAT 722
++K + K RK S + + L E + +DE+ DP+ + LL E N Q ++
Sbjct: 1148 RIKSL-EKDSWRKASRSAAESALKNEGLS-SDEEFDSVYDPSSIASLLTESNLQTSS 1202
>AB037740-1|BAA92557.1| 1208|Homo sapiens KIAA1319 protein protein.
Length = 1208
Score = 79.4 bits (187), Expect = 1e-13
Identities = 159/674 (23%), Positives = 274/674 (40%), Gaps = 68/674 (10%)
Query: 267 KEYQDQIEGLKQEV-DILRKRCE-RVEKEKSDILLRRLANIDTANKYTTG-------RSS 317
++YQ E L++ + D + E++K L+R L TG ++
Sbjct: 525 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 584
Query: 318 EVLKL-QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
E L+ +Q++ +L E++ +E L +KI ++ ELE ++ TRQ+E L+ +LL
Sbjct: 585 EDLRATKQELLQLRMEKEEMEEE---LGEKIEVLQRELEQARASAGDTRQVEVLKKELLR 641
Query: 377 AETLCEELMDENEDMK-------KELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
+ +EL E + + +EL D RE + ++ L++ L+Q +
Sbjct: 642 TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELE-EQNLQLQKTLQQLRQ 700
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-----ENRIKELEQEVAR 484
+C S E +A L Q +A E L E D +R E ++KE V
Sbjct: 701 DCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDG 760
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR---- 540
V RL+ +L ++ +L + E + +E L R
Sbjct: 761 GEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQE 820
Query: 541 --DLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
L +LE E RE LR + E K++ LD+ V N I E
Sbjct: 821 QQTLNRALEEEGKQREVLRRGKAELEEQKRL-----LDRTVDRLNKELEKIGEDSKQALQ 875
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLS-----IFNHMAANNLRKT 653
+ + +E +D+ + D +E + L L + + A+ +
Sbjct: 876 QLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERD 935
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKL 712
AR+ D E L +L+ + +A ++K S A +L +E E E DE L
Sbjct: 936 TARL--DKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELL 993
Query: 713 LLELN------EQEATVL---RRKVEELEQDKEALKKQVKELTSKISS---VTKTSAGSN 760
+N +Q T L R ++LE DK +L++Q K+L ++++S K SA +
Sbjct: 994 TDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLS 1053
Query: 761 TTARRSLTTNSNKLAEERVK-VLEDEIDEVRKKLIEK--ERDCERLHA-----ELSLAQK 812
++ AEER K VL+ ++ +K+ E + + ER H +LSL K
Sbjct: 1054 QLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVK 1113
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA--SVLRAKTQSLEADNEKLQTENKKLQL 870
K + + + K Q +V EQ L+A+ +SLE D+ + + +
Sbjct: 1114 ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESA 1173
Query: 871 LKNAKSLRSDKALD 884
LKN + L SD+ D
Sbjct: 1174 LKN-EGLSSDEEFD 1186
Score = 61.3 bits (142), Expect = 3e-08
Identities = 157/859 (18%), Positives = 338/859 (39%), Gaps = 52/859 (6%)
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
++ +AT+ E + + +++++V + K+ + S+GS T A + K+
Sbjct: 316 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGS-TKAVAGQGELTRKV- 373
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
EE + L++E+ + R+KL + ER E + + + L++ R +A Q N +L+
Sbjct: 374 EELQRKLDEEVKK-RQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQ-QSNKELQN 431
Query: 836 QLQVIEQEASVLRA-KTQSLEADNEKLQT---ENKKLQLLKNAKSLRS--DKALDLNTKK 889
++++Q + +TQ +E N+ E K LLK+ R ++ L+ +
Sbjct: 432 MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 491
Query: 890 TTQL---ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK-SKQXXXXXXXX 945
QL E EL +KE E+ +D++ E VR + +++T+ L+ S Q
Sbjct: 492 EEQLRLRERELTALKGALKE-EVASRDQEVEH-VR--QQYQRDTEQLRRSMQDATQDHAV 547
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQKS--FKPRIPKKPTDL-TTK---LQLKKMVEDLECE 999
+ + L++ ++++ ++ K DL TK LQL+ E++E E
Sbjct: 548 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 607
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+GE V++ + T+ +++ ++ +L + E + Q++ + +
Sbjct: 608 LGEKIEVLQRELEQARASAGDTR---QVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 664
Query: 1060 AKLEGDKDVF---ANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE V A++ + LE +N L + L ++ + EA K+ A+ + AT L
Sbjct: 665 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCE--EASKAKMVAEAE-ATVLGQ 721
Query: 1117 TMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ Q+ + + + DK +++
Sbjct: 722 RRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 781
Query: 1177 XXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQAR 1236
+ E L+ K + + T R E +++ L+
Sbjct: 782 LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRG 841
Query: 1237 FIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS 1296
+ E + L+ + L + E + + ++ ++ R+ D +A
Sbjct: 842 KAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKD 901
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXX 1356
E QDE+ + L+ ++AE A+L+ L L LE
Sbjct: 902 WASEAEK------TSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEA 955
Query: 1357 XXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKL 1416
E K L+T+L E+ ++ + D+ + +D ++ L+ +L
Sbjct: 956 ENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE---LLTDRVNRGRD-QVDQLRTEL 1011
Query: 1417 KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL 1476
+++ S ++ E + K L+ LA + +++ + LE ++ + + RL
Sbjct: 1012 --MQERSARQDLECDKISLERQN--KDLKTRLASSEG-FQKPSASLSQLESQNQLLQERL 1066
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGG 1536
E E+ + L ++L ++K L ++ E N +K ++ + +L+ ++
Sbjct: 1067 QAE-EREKTVLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA 1122
Query: 1537 GWEVERARLNARLDQRERE 1555
E+ER + QRE E
Sbjct: 1123 EEEIERLDGLRKKAQREVE 1141
Score = 53.2 bits (122), Expect = 9e-06
Identities = 122/680 (17%), Positives = 274/680 (40%), Gaps = 41/680 (6%)
Query: 265 NVKEYQDQIE----GLKQEVDILRKRCERVE--KEKSDILLRRLANI-DTANKYTTGRSS 317
N+K DQ E GL+ +V L+ + + V+ + ++LL+ L + + G+
Sbjct: 431 NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQR 490
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
+L+ + ELT L++E Q++ + + + TE R ++
Sbjct: 491 VEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQR--DTEQLRRSMQDATQDHAVL 548
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
E +++ +++EL + Q F++++ D + ++EL Q + +
Sbjct: 549 EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED-LRATKQELLQLRMEKEEMEEE 607
Query: 438 L-KKTERKADQLEQEKAEH-EKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
L +K E +LEQ +A + + +E++ + ++ + +KEL+ E +S EVA R +
Sbjct: 608 LGEKIEVLQRELEQARASAGDTRQVEVLK-KELLRTQEELKELQAE-RQSQEVAGRHRDR 665
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRS--SLTRGGSQEDPAQLLRDLQDSL--EREAD 551
E + + + +++ ++ L + + A+++ + + ++ +R A
Sbjct: 666 ELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAA 725
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVM-TDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+ LR +EE ++ L++Q+ T +V + + +Q
Sbjct: 726 VETTLRETQEENDEFRR--RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLE 783
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ S S+ + + + + A EE + +L+ K
Sbjct: 784 EALNASQEEEGSLAAAKRALEARLEEAQRGLAR-LGQEQQTLNRALEEEGKQREVLRRGK 842
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ + R L T +E + D K+ + A+++ E +E +R+ ++
Sbjct: 843 AELEEQKRLLDRTVDRLNKELEKIGE-DSKQALQQLQAQLEDYKEKARREVADAQRQAKD 901
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
+ E + L +I + + S A R +L +R++ LE E + +
Sbjct: 902 WASEAEKTSGGLSRLQDEIQRLRQALQASQ--AERDTARLDKELLAQRLQGLEQEAENKK 959
Query: 791 KKLIEKERDCE-------RLHAELSLAQKKPKTLIK--SRSLDASDQQNVDLKRQL---Q 838
+ ++ R + RL EL + + L +R D DQ +L ++ Q
Sbjct: 960 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1019
Query: 839 VIEQEASVLRAKTQSLE---ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+E + L + + L+ A +E Q + L L++ L ++ L ++ T L++
Sbjct: 1020 DLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQER-LQAEEREKTVLQS 1078
Query: 896 ELKEALAKIKELEMICQDEK 915
++ K+KEL + +DE+
Sbjct: 1079 TNRKLERKVKELSIQIEDER 1098
Score = 52.0 bits (119), Expect = 2e-05
Identities = 91/431 (21%), Positives = 170/431 (39%), Gaps = 29/431 (6%)
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNS---GAGAKRI 1430
E+ ++ D + R+ + H + A ++G + LE+ S G
Sbjct: 521 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMF 580
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEELTG-KYELLEEEHVVTKARLTVEKEQAQGELLH 1489
+ K++ T ++L L +EK E EE G K E+L+ E + +AR + + Q E+L
Sbjct: 581 QKNKEDLRATKQELLQ-LRMEKEEMEEELGEKIEVLQRE--LEQARASAG-DTRQVEVL- 635
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERARLNAR 1548
+KEL E+K LQ + ++ A E++ +A L+ E G E + +L
Sbjct: 636 -KKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKT 694
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
L Q ++ A+ + V E R ++ +
Sbjct: 695 LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTL----RETQEENDEFRRRILGLEQQ 750
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
+ +A +A + D R E + + + L + + + + LE A
Sbjct: 751 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 810
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
Q+ +A + G + ++R + +EE + +V L + A LE++ +LN E
Sbjct: 811 QRGLARL--GQEQQTLNR----ALEEEGKQREV--LRRGKAELEEQKRLLDRTVDRLNKE 862
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQET 1788
L ++ L ++Q++L +Y+E+ R VA A R W E ++ L
Sbjct: 863 LEKIGEDSKQALQQLQAQLEDYKEK-----ARREVAD-AQRQAKDWASEAEKTSGGLSRL 916
Query: 1789 STLARDLRQTL 1799
+ LRQ L
Sbjct: 917 QDEIQRLRQAL 927
Score = 48.8 bits (111), Expect = 2e-04
Identities = 149/826 (18%), Positives = 316/826 (38%), Gaps = 67/826 (8%)
Query: 335 DLRDEKKHLTQKI-REIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKK 393
+L + + L +K+ E++ + PS RQ+E+ + + L E E + K
Sbjct: 368 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 427
Query: 394 ELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ---- 447
EL+++ +D + E Q E + + ++ VL L +T ++
Sbjct: 428 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 487
Query: 448 ---LEQEKAEHEKKLLEIVGG--PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSK 502
+E++ E++L + G + R+ ++ + Q+ R TE R ++ + ++
Sbjct: 488 KQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAV 547
Query: 503 FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEE 562
+ + + ++ +S G Q + DL+ + + LR + EEE
Sbjct: 548 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 607
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
+V L +++ D + E + + + ++ +
Sbjct: 608 LGEKIEV-----LQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRH 662
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARVEEDNESLLLQLKKMATKARSRKL 680
D+ E+ Q + N L+KT ++ +D E KM +A + L
Sbjct: 663 RDRELEK-QLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE--ASKAKMVAEAEATVL 719
Query: 681 SPTPPANKLSI-ETANDNDEKETD----EADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
A + ++ ET +NDE E E + L++ E LR K++ LE +K
Sbjct: 720 GQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEK 779
Query: 736 EALKKQV---KELTSKISSVTKTSAGSNTTARRSLT------TNSNKLAEERVK---VLE 783
+ L++ + +E +++ + A+R L N+ EE K VL
Sbjct: 780 QQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 839
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
E+ ++ +R +RL+ EL + K ++ D + +R++ +++
Sbjct: 840 RGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKE-KARREVADAQRQ 898
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAK-----SLRSDKAL----------DLNTK 888
A ++ + +LQ E ++L+ A + R DK L + K
Sbjct: 899 AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENK 958
Query: 889 KTTQLE--NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
K +Q + +LK K+ LE +EK+ ++ T+ + D + +
Sbjct: 959 KRSQDDRARQLKGLEEKVSRLETELDEEKNTVEL-LTDRVNRGRDQVDQLRTELMQERSA 1017
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKP-TDLTTKLQLKKMVEDLECEIGEMYV 1005
+ K LK S + P + L ++ QL + E L+ E E V
Sbjct: 1018 RQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL--LQERLQAEEREKTV 1075
Query: 1006 VMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ + +++ K K L +I++ R ++ + + L+ ++ + ++ +L+G
Sbjct: 1076 LQS----TNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDG 1131
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
+ + + N L + K+L E+ R+A + + LKN
Sbjct: 1132 LRKKAQREVEEQHEVNEQLQARIKSL-EKDSWRKASRSAAESALKN 1176
Score = 48.4 bits (110), Expect = 3e-04
Identities = 103/563 (18%), Positives = 216/563 (38%), Gaps = 53/563 (9%)
Query: 1239 KTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK-YDEATSP 1297
+ E + E E+ LK + ++ S + + ++ + LR++ D D A
Sbjct: 490 RVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLE 549
Query: 1298 VEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXX 1357
E +M +E + + +K + + A K E+ QL+ + ++E
Sbjct: 550 AERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG 609
Query: 1358 XXXXXXXXXX--XXSSYWENKAKE-LDTDL---QSERKKLDRMRIAHDKDVKNKDAELAT 1411
+S + + E L +L Q E K+L R + + +++D EL
Sbjct: 610 EKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEK 669
Query: 1412 LKGKLKI-------LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
L++ LE+ + K + +L+Q+ EE K + + +AE L +
Sbjct: 670 QLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK----AKMVAEAEATVLGQRRAA 725
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEI---KTLQEKLGTESAAWNTEKTE 1521
+E T E ++ + +L ++++L G + + ++ +L + EK +
Sbjct: 726 VE----TTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 781
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
++ ++ + QE G + L ARL++ +R L + L +
Sbjct: 782 LEEALNASQEE--EGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 839
Query: 1582 XXXXDYER--------VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTK--- 1630
+ E V ++ + +E ++ + E+ D +
Sbjct: 840 RGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQA 899
Query: 1631 -------TRYEGQMNTMRDELKSLHNQVSRFRRERDNY---KQML-EAAQKSMAEIKNGD 1679
+ G ++ ++DE++ L + + ERD K++L + Q E +N
Sbjct: 900 KDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKK 959
Query: 1680 KSARIHRNSISSTDEEEYRNKVALLEQQ--VACLEDELCESRLLASKLNTELVSEKSSAE 1737
+S + +E+ R + L E++ V L D + R +L TEL+ E+S+ +
Sbjct: 960 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1019
Query: 1738 VRLAEMQS--RLNEYEEERLLSS 1758
+ S R N+ + RL SS
Sbjct: 1020 DLECDKISLERQNKDLKTRLASS 1042
Score = 42.3 bits (95), Expect = 0.017
Identities = 100/477 (20%), Positives = 184/477 (38%), Gaps = 32/477 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ +KE + ++G + LR + +R+E EK L N + + +
Sbjct: 747 LEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ--LEEALNASQEEEGSLAAAKRA-- 802
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L+ ++ E L E++ L + + E + E +A+ EQ R + L
Sbjct: 803 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE--EQKRLLDRTVDRLN 860
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+EL ED K+ L+ L ++ R + AD + + K LS +
Sbjct: 861 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 920
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+R L+ +AE + L D R++ LEQE R+L
Sbjct: 921 QRLRQALQASQAERDTARL------DKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEE 974
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP--AQLLRDLQDSLEREAD---LREQL 556
K + L + + TV++ + RG Q D +L+++ + E D L Q
Sbjct: 975 KVSRLETELDE--EKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN 1032
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE----TVTNSIQNKMIHAASTPSS 612
++ + A+ + P+ Q+ + N + + ++E TV S K+ S
Sbjct: 1033 KDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSI 1092
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNH--MAANNLRKTAAR-VEED---NESLLL 666
+ + + ++ K + + + LRK A R VEE NE L
Sbjct: 1093 QIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQA 1152
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM-KLLLELNEQEAT 722
++K + K RK S + + L E + +DE+ DP+ + LL E N Q ++
Sbjct: 1153 RIKSL-EKDSWRKASRSAAESALKNEGLS-SDEEFDSVYDPSSIASLLTESNLQTSS 1207
>AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein.
Length = 3908
Score = 78.6 bits (185), Expect = 2e-13
Identities = 182/874 (20%), Positives = 362/874 (41%), Gaps = 87/874 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
DEK E E +++ EQE +++ELE +++ ++++ +EL S+ K A
Sbjct: 1930 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLSRQKEAMKAEA 1988
Query: 758 GSNTTARRSLTTNSNKLAEERVKV---LEDEIDEVRKKLIEKERDCE-RLHAELSLAQKK 813
G + L + KL +E+++V E D+++K++ E D E ++ + L Q+K
Sbjct: 1989 GP---VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK 2045
Query: 814 PKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLK 872
L+ R QQN L++QL E+ L + E + + Q E +KL Q LK
Sbjct: 2046 NTELMDLR------QQNQALEKQL---EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2096
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
R + T++ QL N LKE K EL + + + + + R E K E
Sbjct: 2097 VVP--RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 2154
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTT-KLQLK 990
+ +Q L + Q ++ + I +K ++T + QL+
Sbjct: 2155 RELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2214
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKE-------IDEIRSKLSKNDSEFT 1042
+ E+LE + E+ + + KE T + + LE+E ++++ + ++D+ T
Sbjct: 2215 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2274
Query: 1043 NEKNRL-----------QTEIAKLKDVNAKLEGDKDVFANKYKALENENS---NLSNQCK 1088
+++ L + EI +L + KL+ + + K +E +N +L Q +
Sbjct: 2275 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN-KVIEEKNELIRDLETQIE 2333
Query: 1089 TLTEEM----KNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
L + +NRE +I +L+ ++ LQ +++
Sbjct: 2334 CLMSDQECVKRNREEEIEQLNEVIEK---LQQELANI---GQKTSMNAHSLSEEADSLKH 2387
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQL-STRKDRVTXXXX 1203
Q+D + +K L ++V +++ ++ ++L S +++R +
Sbjct: 2388 QLD---VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKI 2444
Query: 1204 XXXXXXXQAVVLANTHR-RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKI 1262
V + + + + +E+ +D L++ ++ ++ F + E + + E ++
Sbjct: 2445 QSIPENSVNVAIDHLSKDKPELEVVLTEDALKS--LENQTYFKSFEENGKGSIINLETRL 2502
Query: 1263 TSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQDEL 1321
LEST++AKD+ + Q ++ +++ ++V ++ Q +L
Sbjct: 2503 LQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL 2562
Query: 1322 NNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELD 1381
+ + + + + +L +L S E++ E+
Sbjct: 2563 EAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI--SELESQVVEMH 2620
Query: 1382 TDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
T L E+++++ IA +K+V K+ +L L+ L+ E+ K+ + E +T
Sbjct: 2621 TSLILEKEQVE---IA-EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTT 2676
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQA---QGELL-------HVQ 1491
+L HS E + EL E L E V TKA L KE+A Q ELL +Q
Sbjct: 2677 TELFHSNE-ESGFFNEL----EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQ 2731
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
K+LS + +EKL S ++TE+Q S
Sbjct: 2732 KDLSQVRDHLAEAKEKL---SILEKEDETEVQES 2762
Score = 70.5 bits (165), Expect = 6e-11
Identities = 142/682 (20%), Positives = 289/682 (42%), Gaps = 70/682 (10%)
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR----ENRIKELEQEVARSTEVALRL 492
++ ++E Q E E+ E + + + G +G+Q+ E IK+ + + + T +
Sbjct: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
Query: 493 QRELAEANSKF---TGSNPSLM----KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
+RE E +F T + L ++ ET++ S S T + Q+L Q
Sbjct: 218 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH-QQQ 276
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
LE + L E + +E+ Q+ +FL +++ ++E E Q+K +
Sbjct: 277 LEEQDHLLEDYQKKKEDFT--MQI---SFLQEKI--------KVYEME------QDKKVE 317
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
++ +EK K EE + +L L++ + ++ +++
Sbjct: 318 NSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 377
Query: 666 LQLKKMATKAR-SRKLSPTPPANKLSIETANDNDEK-ETDEADPAEMKLLLELNEQEATV 723
L+L K R S + ++ N D + ETD E + +L + A +
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
+++ Q K+ L +++ +++ + G A RS + + + E+++K++
Sbjct: 438 DEMYGQQIVQMKQEL---IRQHMAQMEEMKTRHKGEMENALRSYSNIT--VNEDQIKLMN 492
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
I+E+ KL + E+L EL L ++ L R L+ DL +L ++
Sbjct: 493 VAINELNIKLQDTNSQKEKLKEELGLILEEKCAL--QRQLE-------DLVEELSFSREQ 543
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ RA+ Q++ KL +K L +++ L+++ ++K +L++E + K
Sbjct: 544 --IQRAR-QTIAEQESKLNEAHKSLSTVED---LKAEIVSASESRKELELKHEAEVTNYK 597
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
IK LEM+ + EK+ R E+ + E + L++ Q + ++
Sbjct: 598 IK-LEML-EKEKNAVLDRMAESQEAELERLRT-QLLFSHEEELSKLKEDLEIEHRINIEK 654
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED--------LECEIGEMYVVMKN-AGLSG 1014
LKD+ +K +I +++ K++ + +D L EI ++ + ++
Sbjct: 655 LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS 714
Query: 1015 KEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+EMT + +L+KEI+ +R + K E LQ + L+ + E D K+
Sbjct: 715 EEMTLQINELQKEIEILRQE-EKEKGTLEQEVQELQLKTELLEKQMKEKEND---LQEKF 770
Query: 1074 KALENENSNLSNQCKTLTEEMK 1095
LE ENS L ++ KTL + +K
Sbjct: 771 AQLEAENSILKDEKKTLEDMLK 792
Score = 62.1 bits (144), Expect = 2e-08
Identities = 130/691 (18%), Positives = 286/691 (41%), Gaps = 59/691 (8%)
Query: 267 KEYQDQIEGLKQEVDILR-KRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+++ QI L++++ + ++ ++VE + + + I+ N + L+L+ K
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 351
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
LTT ++ L + ++ + QK +EI++ +LE S + + + E+++ + E L +
Sbjct: 352 ---LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 408
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++ ++ + + R + + Y +++Q + + + KT K
Sbjct: 409 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 468
Query: 445 ADQLEQEKA-------EHEKKLLEIVGGPDG--MQRENRIKE-LEQEVARSTEVALRLQR 494
+ ++ E + KL+ + +Q N KE L++E+ E LQR
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L + + + S + + Q T+ S L + DL+ + ++ R+
Sbjct: 529 QLEDLVEELSFSREQIQRARQ--TIAEQESKLNEAHKS---LSTVEDLKAEIVSASESRK 583
Query: 555 QLR-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
+L E E N K +K + D + E ++ +++ + SK
Sbjct: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA----ESQEAELERLRTQLLFSHEEELSK 639
Query: 614 EKSD---SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
K D ++I+K + H+ + N M+ + + E+DN
Sbjct: 640 LKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ---KIETMQFEKDN--------- 687
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEATVLRRKVE 729
+ TK +++ + L N E+ T + + + ++ +L E+E L ++V+
Sbjct: 688 LITK-QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ 746
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL-------AEERVKVL 782
EL+ E L+KQ+KE + + N+ + T + L EER+ L
Sbjct: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQ---KKPKTLIKSRSLDASDQQNVDLKRQLQV 839
+ + + + EKE + + L Q + + + K R+ + ++N ++ Q ++
Sbjct: 807 DSIKSKSKDSVWEKEIEI-LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-EL 864
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENK-KLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
E+ A +L+ K LE K + E K KL+ L + L + K + + +E K
Sbjct: 865 QEEYACLLKVK-DDLEDSKNKQELEYKSKLKALN--EELHLQRINPTTVKMKSSVFDEDK 921
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKE 929
+A+ E+ + + + +E + E TK+E
Sbjct: 922 TFVAETLEMGEVVEKDTTELMEKL-EVTKRE 951
Score = 56.0 bits (129), Expect = 1e-06
Identities = 150/836 (17%), Positives = 344/836 (41%), Gaps = 65/836 (7%)
Query: 290 VEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIRE 349
++ E +++L + + A + SE Q + T E +R+ + +
Sbjct: 1836 IDPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATES 1893
Query: 350 IESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNF 409
++ + E R ++R EQL +L AE + + DE ++++++ ++
Sbjct: 1894 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1953
Query: 410 REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGM 469
++ L E +Q + +LS + + + +A +EQ+ + +KL++ + +
Sbjct: 1954 L-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK-----EKL 2007
Query: 470 QRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG 529
+ + + +++ ++ + + L+ ++ E S+F L + E + + + +
Sbjct: 2008 EVQCQAEKVRDDLQKQVKA---LEIDVEEQVSRFI----ELEQEKNTELMDLRQQNQALE 2060
Query: 530 GSQEDPAQLLRDLQDSLEREADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD 588
E + L + E E D+ +++++ E++ K V P F Q ++++
Sbjct: 2061 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ---LKVV--PRF---QPISEH----Q 2108
Query: 589 IHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQ-FHFDLPYLSIFNHMAA 647
E E + N ++ K + SKE+ I + EE + F + L ++A
Sbjct: 2109 TREVEQLANHLKEKTDKCSELLLSKEQLQR---DIQERNEEIEKLEFRVRELEQALLVSA 2165
Query: 648 NNLRKTAAR----VEEDNESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKET 702
+ +K R E L L+++ A + A RK L + +E E
Sbjct: 2166 DTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK---EKEITNLEEQLEQFREELEN 2222
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEE----LEQDKEALKKQVKELTSKISSVTKTSAG 758
+ ++ + LE+ ++E+T +++E+ + D E L +KE + + G
Sbjct: 2223 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2282
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCER-LHAELSLAQKKPKTL 817
+ ++L E+ K+ + K+IE++ + R L ++ + +
Sbjct: 2283 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 2342
Query: 818 IKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAKS 876
++R +++ L ++ ++QE + + KT S+ A + + ++ K QL + A+
Sbjct: 2343 KRNR-----EEEIEQLNEVIEKLQQELANIGQKT-SMNAHSLSEEADSLKHQLDVVIAEK 2396
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
L ++ ++ ++ T ++N LKE K+ +L Q+ S K+ R E+ +K ++
Sbjct: 2397 LALEQQVETANEEMTFMKNVLKETNFKMNQL---TQELFSLKRER--ESVEK-IQSIPEN 2450
Query: 937 QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTTK-LQLKKMVE 994
+ LKSL++ KSF+ +L T+ LQL+ V
Sbjct: 2451 SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVS 2510
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT--EI 1052
+ E+ + Y +K+ G+ T L+K+I ++ + + + + +L+ E
Sbjct: 2511 AKDLELTQCYKQIKDMQEQGQFET--EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 2568
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
AK N + + + N + L + LT + E+Q+ ++ L
Sbjct: 2569 AKFCQDNQTISSEPE-RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSL 2623
Score = 55.2 bits (127), Expect = 2e-06
Identities = 149/790 (18%), Positives = 330/790 (41%), Gaps = 65/790 (8%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT--RQIEQLRAKLLAAETL 380
+Q + TH E + E +I E+ ELE T +Q+++ A + + +
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
Query: 381 CEELMD-------ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKNCR 432
+L E ++ +E +L +Q F++ QA E +LR T +
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASE--TLRNSTHSSTAADLL 264
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ +++ ++ + +++KK + +Q + ++ E+EQ+ +V
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----KKVENSN 320
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+ E+ E + N +++ + +T+++ + LT +LL +LQ+ + ++
Sbjct: 321 KEEIQEKETIIEELNTKIIE-EEKKTLEL-KDKLTTAD------KLLGELQEQIVQK--- 369
Query: 553 REQLRNAEEETANCKQVNPPTFLD-KQVM-TDNIVTCDIHESETVTNSIQNKMIHAASTP 610
++++N + E N KQ + + KQ+M T + H+ I +M
Sbjct: 370 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ +++ + + + Q +L I HMA KT + E +N L
Sbjct: 430 LEQLRAELDEMYGQQIVQMKQ---EL----IRQHMAQMEEMKTRHKGEMENA--LRSYSN 480
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ KL N+L+I+ + N +KE + E+ L+LE L VEE
Sbjct: 481 ITVNEDQIKLMNVA-INELNIKLQDTNSQKEKLKE---ELGLILEEKCALQRQLEDLVEE 536
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTA--RRSLTTNSNKLAEERVKVLEDEIDE 788
L +E +++ + + + S + + +T + + + S E +K E E+
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKH-EAEVTN 595
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
+ KL E++ + ++ +Q+ ++++ L + +++ LK L+ IE ++ +
Sbjct: 596 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEK 654
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
K + K Q + + ++ + ++++ +K +L TK +N+L ++K+K+L+
Sbjct: 655 LKDNL--GIHYKQQIDGLQNEMSQKIETMQFEKD-NLITK-----QNQLILEISKLKDLQ 706
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ KSE+ +KE + L+ ++ + +K ++D
Sbjct: 707 QSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDL 766
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
Q+ F + K L+ M++ E ++ + S K + + EKEI
Sbjct: 767 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD---SIKSKSKDSVWEKEI- 822
Query: 1029 EIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
EI L + + + + +L EI K ++ + E + +V Y+ L+ E + L + K
Sbjct: 823 EI---LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLL-KVK 875
Query: 1089 TLTEEMKNRE 1098
E+ KN++
Sbjct: 876 DDLEDSKNKQ 885
Score = 53.6 bits (123), Expect = 7e-06
Identities = 84/413 (20%), Positives = 167/413 (40%), Gaps = 32/413 (7%)
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTS-KISSVTKTSAGSNTTARRSLTT 769
KLL ++E + + KV + E +E+ +++ + S K + + AR L
Sbjct: 1857 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1916
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
+K AE + DE +++ EK +RL EL A + + L ++QQ
Sbjct: 1917 ELSK-AEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL-------EAEQQ 1968
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ +R+L ++EA ++A+ +E ++L E +KL K +++K D K+
Sbjct: 1969 QIQEERELLSRQKEA--MKAEAGPVE---QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ 2023
Query: 890 TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXX 949
LE +++E +++ ELE EK + ++ K +
Sbjct: 2024 VKALEIDVEEQVSRFIELEQ-------EKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2076
Query: 950 XXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMK 1008
Q ++ L+ Q PR T ++ QL +++ + E+ + +
Sbjct: 2077 REHERDVFQQEIQKLEQ--QLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2134
Query: 1009 NAGLSGKEMTAKT-KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK---DVNAKLEG 1064
+E + KLE + E+ L + F ++R + K + +L+
Sbjct: 2135 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQA 2194
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
++D K E E +NL Q + EE++N+ ++ +L L+ TT
Sbjct: 2195 ERDAIDRK----EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2243
Score = 51.2 bits (117), Expect = 4e-05
Identities = 133/710 (18%), Positives = 295/710 (41%), Gaps = 66/710 (9%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
+ Q Q++ L+ +V+ R +E+EK+ L+ + ++ K+++ ++
Sbjct: 2019 DLQKQVKALEIDVEEQVSRFIELEQEKNTELM-------DLRQQNQALEKQLEKMRKFLD 2071
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELET----RPSTEAQTRQIEQLRAKLLAAETLCEE 383
E E RD Q+I+++E +L+ +P +E QTR++EQL L C E
Sbjct: 2072 EQAIDREHERDV---FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2128
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
L+ E +++++++ ++ FR + ++ + + Q +++ + K E
Sbjct: 2129 LLLSKEQLQRDIQERNEEIEKLE--FRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 2186
Query: 444 KAD-QLEQEKAEHEKKLLEIVGGPDGMQR-----ENRIKELEQ-----EVARSTEVALRL 492
+ QL+ E+ ++K EI + +++ EN+ +E++Q E+ + E RL
Sbjct: 2187 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK-ESTTRL 2245
Query: 493 QRELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
Q EL + N F L + + + + + + G + + ++ E+
Sbjct: 2246 Q-ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2304
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQV---MTDNIVTC-----DIHESETVTNSIQNKM 603
L++QL+ + ++ L+ Q+ M+D +I + V +Q ++
Sbjct: 2305 LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQEL 2364
Query: 604 IH-----AASTPSSKEKSDSPPLSIDKT-TEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+ + + S E++DS +D E+ + + N L++T ++
Sbjct: 2365 ANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKM 2424
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKE---TDEA-----DPAE 709
+ + L LK+ + P N + D E E T++A +
Sbjct: 2425 NQLTQE-LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2483
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
K E + L ++ +LE A ++ + +I + + ++ +
Sbjct: 2484 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI-V 2542
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLI-EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
N K+ EE KV + +++ + + E + C+ +++ + +T I++ + D+
Sbjct: 2543 NLQKIVEE--KVAAALVSQIQLEAVQEYAKFCQ---DNQTISSEPERTNIQNLNQLREDE 2597
Query: 829 QNVDLKR-QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
D+ L++ E E+ V+ T SL + E+++ K + L K K L K L+ N
Sbjct: 2598 LGSDISALTLRISELESQVVEMHT-SLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNE 2655
Query: 888 KKTTQLENELKEALAKIKELEMICQ-DEKSEKKVRFTEATKKETDTLKSK 936
KK Q E E K + ++ L+ + +E+ F E +++ +K
Sbjct: 2656 KK--QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2703
Score = 50.8 bits (116), Expect = 5e-05
Identities = 127/686 (18%), Positives = 284/686 (41%), Gaps = 55/686 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ ++++++++E +EV L + E +KE + RL ++ NK ++
Sbjct: 2209 LEEQLEQFREELENKNEEVQQLHMQLEIQKKEST----TRLQELEQENKLFKDDMEKLGL 2264
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
++ + ++T ++ + K Q I+E E E++ Q +++Q + K+ +
Sbjct: 2265 AIKESDAMSTQDQHVLFGK--FAQIIQEKEVEID---QLNEQVTKLQQ-QLKITTDNKVI 2318
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKLKK 440
EE + D++ ++ L ++ N RE++ ++ + + +L+Q + N + S
Sbjct: 2319 EEKNELIRDLETQIECLMSDQECVKRN-REEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2377
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAEA 499
+AD L K + + + E + ++ N + V + T + +L +EL
Sbjct: 2378 LSEEADSL---KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2434
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
+ S + +P+ +V V+ L++ E L D SLE + + N
Sbjct: 2435 KRE-RESVEKIQSIPE-NSVNVAIDHLSK-DKPELEVVLTEDALKSLENQTYFKSFEENG 2491
Query: 560 EEETANCK----QVNPPTFLDKQVMTDNIVTC-DIHE-SETVTNSIQNKMIHAASTPSSK 613
+ N + Q+ +T D+ E + T +Q K+++ K
Sbjct: 2492 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2551
Query: 614 EKSD-SPPLSIDKTTEETQFHFDLPYLSI----FNHMAANNLRKTAARVEEDNESLLLQL 668
+ + ++ E +F D +S N N LR+ + D +L L++
Sbjct: 2552 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED--ELGSDISALTLRI 2609
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
++ ++ S K +E A N ++ E E++ LLE NE +K
Sbjct: 2610 SELESQVVEMHTSLI--LEKEQVEIAEKNVLEK--EKKLLELQKLLEGNE-------KKQ 2658
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
E E+ + +V + T+++ + S N + + K AE + +++ ++
Sbjct: 2659 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK-AE--LASYKEKAEK 2715
Query: 789 VRKKLIEKERDCERLHAELS-----LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
++++L+ KE + L +LS LA+ K K I L+ D+ V ++ + E
Sbjct: 2716 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSI----LEKEDETEVQESKKACMFEPL 2771
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
L S K+ + N+ Q+L ++ + + ++++ T++ ++ E + K
Sbjct: 2772 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 2831
Query: 904 IKELEMICQDEKSEKKVRFTEATKKE 929
++EL + + + TE K+E
Sbjct: 2832 MQELHAAEILDMESRHISETETLKRE 2857
Score = 49.2 bits (112), Expect = 1e-04
Identities = 128/666 (19%), Positives = 264/666 (39%), Gaps = 57/666 (8%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
E LQ+++ +L R++ + Q I E ES+L +E L+A++++A
Sbjct: 522 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN---EAHKSLSTVEDLKAEIVSA 578
Query: 378 ETLCEELMDENE----DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN-CR 432
+EL ++E + K +L L + D E Q E LR +L + +
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638
Query: 433 VLSFKLKKTER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
L L+ R ++L+ H K+ ++ + + E E + + + ++ L
Sbjct: 639 KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 698
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPET---VKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
+ + L + S M + E +++ R G+ E Q L+ + LE+
Sbjct: 699 ISK-LKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757
Query: 549 -----EADLREQLRNAEEETANCKQVNPPTFLDKQVMT-----DNIVTCDIHESETVTNS 598
E DL+E+ E E + K ++ T + ++ D +S++ +S
Sbjct: 758 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKS-KDS 816
Query: 599 IQNKMIHAASTPSSKEKSDSPPLS--IDKTTEETQF---HFDLPYLSIFNHMAANNLRKT 653
+ K I + K L+ I+K F +F++ Y + A L K
Sbjct: 817 VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC--LLKV 874
Query: 654 AARVEEDNESLLLQ----LKKMATKARSRKLSPTPPANKLSIE------TANDNDEKETD 703
+E+ L+ LK + + ++++PT K S+ A + E
Sbjct: 875 KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVV 934
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
E D E+ LE+ ++E L +++ +L + + ++ L ++ S+ +
Sbjct: 935 EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKPKPGEISFLNEEVKSLKPEKEPVSLRC 994
Query: 764 RR-SLTTNSNKL-----AEERVKVLEDEIDEVRKKLIEKE-RDCERLHAELSLAQKKPKT 816
R + N N+ + +V L D + + + E + E S + K
Sbjct: 995 RELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV 1054
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLK 872
++ ++ +Q + L + +E+S LRA S L+ + L++E L+L
Sbjct: 1055 SFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPSENDKLQKELNVLKSEQNDLRLQM 1113
Query: 873 NAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
A+ + + + + +ENE +AL +KE + Q+EK ++ + + E
Sbjct: 1114 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL---ELQ 1170
Query: 932 TLKSKQ 937
T+K+++
Sbjct: 1171 TMKTQE 1176
Score = 44.8 bits (101), Expect = 0.003
Identities = 74/358 (20%), Positives = 155/358 (43%), Gaps = 27/358 (7%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA----AKD---VHIKQLE- 1280
EKDE F++ + L+ + + L+A + ++ ST A AK H +QLE
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279
Query: 1281 -DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
D L + K ++ T + ++ + + N +I+ ++T E K
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKV--ENSNKEEIQEKETIIEELNTK 337
Query: 1340 LEMAQLKS-DLA-KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-- 1395
+ + K+ +L KL + +N EL Q ER+ + ++
Sbjct: 338 IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQL 397
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI-TELKQEYEETVKKLEHSLALE 1451
+ + +KD++ T ++ +EQ + +++ EL + Y + + +++ L +
Sbjct: 398 MGTVEELQKRNHKDSQFET--DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQ 455
Query: 1452 K-AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ-KELSTALGEIKTLQEKLG 1509
A+ EE+ +++ E + + + +TV ++Q + L++V EL+ L + + +EKL
Sbjct: 456 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK--LMNVAINELNIKLQDTNSQKEKLK 513
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
E EK +Q + L E L +++RAR + ++E +L A+ +E
Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRAR--QTIAEQESKLNEAHKSLSTVE 569
Score = 44.4 bits (100), Expect = 0.004
Identities = 82/447 (18%), Positives = 182/447 (40%), Gaps = 25/447 (5%)
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK- 1434
+AK+ Q + ++ D + + K ++ +++ L+ K+K+ E + + +
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
QE E +++L + E+ + EL K ++ + ++ + ++ + L +
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSK 384
Query: 1495 STALGEIKTLQEKLGT--ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+ +++ +GT E N + ++ + I E+ E RA L+ Q+
Sbjct: 385 QKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 444
Query: 1553 ERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+++ R+ + + + Y ++ +
Sbjct: 445 IVQMKQELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ 503
Query: 1613 XXIEQSEKARK--AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
Q EK ++ I + K + Q+ + +EL Q+ R R+ + L A K
Sbjct: 504 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 1671 SMA---EIKNGDKSARIHRNSISSTDEEE---YRNKVALLEQQVACLEDELCESR-LLAS 1723
S++ ++K SA R + E E Y+ K+ +LE++ + D + ES+
Sbjct: 564 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 1724 KLNTELV---SEKSSAEVRLAEMQSRLN-EYEEERLLSSGRARVAGLATRME-----LAW 1774
+L T+L+ E+ S E++ R+N E ++ L + ++ GL M + +
Sbjct: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
Query: 1775 HKER--DEQQRLLQETSTLARDLRQTL 1799
K+ +Q +L+ E S L +DL+Q+L
Sbjct: 684 EKDNLITKQNQLILEISKL-KDLQQSL 709
Score = 43.6 bits (98), Expect = 0.007
Identities = 144/720 (20%), Positives = 289/720 (40%), Gaps = 86/720 (11%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQK- 346
ER +EK+DI+ R + A+ +E ++Q++ L+ E ++ E + Q+
Sbjct: 1936 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL 1995
Query: 347 IREIESELETRPSTEAQTRQI-----EQLRAKLLAAETLCEELMDENEDMKKELRDLXXX 401
++E E ++ + + Q ++ +Q++A + E ++ ++ EL DL
Sbjct: 1996 LQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQ 2055
Query: 402 XXXMQDNF-------------REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
++ RE + D + ++LEQ +K + R+ +QL
Sbjct: 2056 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQL 2115
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRE-----NRIKELEQEVARSTEVALRLQRELAE--ANS 501
E K E++ + +QR+ I++LE V R E AL + + + +
Sbjct: 2116 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV-RELEQALLVSADTFQKVEDR 2174
Query: 502 KFTG---SNPSL-MKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
K G + P L ++V Q E + R +E Q +L++ E L QL
Sbjct: 2175 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2234
Query: 557 R-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI-HAASTPSSKE 614
+E T +++ L K M + I ES+ ++ Q+ + A KE
Sbjct: 2235 EIQKKESTTRLQELEQENKLFKDDMEK--LGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2292
Query: 615 -KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN------NLRKTAARVEEDNESLLLQ 667
+ D + K ++ + D + N + + L V+ + E + Q
Sbjct: 2293 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2352
Query: 668 LKKMATKARSR--KLSPTPPANKLSIETANDNDEKETDE--ADPAEMKLLLELNEQEATV 723
L ++ K + + N S+ D+ + + D A+ ++ +E +E T
Sbjct: 2353 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2412
Query: 724 LRR-------KVEELEQDKEALKKQVKELTSKISSVTKTSAG-SNTTARRSLTTNSNKLA 775
++ K+ +L Q+ +LK++ +E KI S+ + S + + L
Sbjct: 2413 MKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2471
Query: 776 EERVKVLEDE-------------IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
E+ +K LE++ I + +L++ E EL+ K+ K + +
Sbjct: 2472 EDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 2531
Query: 823 LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA---------DNEKLQTENKKLQLLKN 873
+ Q + Q V E+ A+ L ++ Q LEA DN+ + +E ++ ++N
Sbjct: 2532 FETEMLQKKIVNLQKIVEEKVAAALVSQIQ-LEAVQEYAKFCQDNQTISSEPERTN-IQN 2589
Query: 874 AKSLRSDK-ALDLN--TKKTTQLENELKE---ALAKIKELEMICQDEKSEKKVRFTEATK 927
LR D+ D++ T + ++LE+++ E +L KE I + EK+ + E K
Sbjct: 2590 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK 2649
Score = 41.1 bits (92), Expect = 0.039
Identities = 73/339 (21%), Positives = 145/339 (42%), Gaps = 26/339 (7%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
+ +EL+S KD R + + + + + + +LK++ LE+T+ A+ H+K+LE
Sbjct: 3137 MQVELSSMKD----RATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE- 3191
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
A R DK DE V + + Q L K KL ++E E +LE
Sbjct: 3192 AFRLEVKDKTDE----VHL--LNDTLASEQKKSRELQWALEKEKAKLGRSE-ERDKEELE 3244
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKEL--DTDLQSER-KKLDRMRIAH 1398
+ + K N S + +++ + D L E+ + L+ +
Sbjct: 3245 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLE 3304
Query: 1399 DKDVKNKDAELATLKGKLKI---LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEY 1455
+ V+ ++ +TL + ++ L+ + G G R L E+ +K+L+ L + +
Sbjct: 3305 SEKVRIREMS-STLDRERELHAQLQSSDGTGQSR-PPLPS--EDLLKELQKQLEEKHSRI 3360
Query: 1456 EELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
EL + E + + + T+ ++ ++ Q + L ++E +T G+ K + + E
Sbjct: 3361 VELLNETEKYKLDSLQTRQQMEKDR-QVHRKTLQTEQEANTE-GQKKMHELQSKVEDLQR 3418
Query: 1516 NTEKTEMQNSIASLQ-ERLCGGGWEVERARLNARLDQRE 1553
E+ Q L+ +RL G E ++ L R ++RE
Sbjct: 3419 QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELE-REEKRE 3456
Score = 39.9 bits (89), Expect = 0.091
Identities = 71/314 (22%), Positives = 144/314 (45%), Gaps = 27/314 (8%)
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD 703
H N + T R +E + L+ + +S+ L + + ++ ++
Sbjct: 3099 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3158
Query: 704 EADPAEMKLLLELNEQEA-TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ AE+K L + E T L+ + + L++ EA + +VK+ T ++ + T A
Sbjct: 3159 KMVVAELKSELAQTKLELETTLKAQHKHLKE-LEAFRLEVKDKTDEVHLLNDTLASEQKK 3217
Query: 763 ARR---SLTTNSNKL--AEERVKVLEDEIDEVRKKL-IEKERDCE---RLHAELSLAQKK 813
+R +L KL +EER K +E+++++ L +K+R+ + L + L +
Sbjct: 3218 SRELQWALEKEKAKLGRSEERDK---EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3274
Query: 814 PKTLIKSRSL-DA--SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE---KLQTENKK 867
+ + R L DA S++Q +L+ Q+ ++E E +R + +L+ + E +LQ+ +
Sbjct: 3275 QQKIESQRMLYDAQLSEEQGRNLELQV-LLESEKVRIREMSSTLDRERELHAQLQSSDGT 3333
Query: 868 LQL---LKNAKSLRS-DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
Q L + L+ K L+ + +L NE ++ K+ L+ Q EK + R T
Sbjct: 3334 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKT 3391
Query: 924 EATKKETDTLKSKQ 937
T++E +T K+
Sbjct: 3392 LQTEQEANTEGQKK 3405
Score = 39.5 bits (88), Expect = 0.12
Identities = 56/254 (22%), Positives = 114/254 (44%), Gaps = 24/254 (9%)
Query: 1260 NKITSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
++I +L + + + + +K+ +++ + + +Y+ +M+EM+ Q
Sbjct: 3093 SEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3152
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSD---LAKLENXXXXXXXXXXXXXXXS---S 1371
++L++ K+ + + ++E + KLE+ LK+ L +LE + +
Sbjct: 3153 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3212
Query: 1372 YWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRIT 1431
+ K++EL L+ E+ KL R DK+ EL LK L+ +Q + +
Sbjct: 3213 SEQKKSRELQWALEKEKAKLGRSE-ERDKE------ELEDLKFSLESQKQRNLQLNLLLE 3265
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGK----YELLEEEHV-VTKARLTVEKEQAQGE 1486
+ KQ E+ +K+E L A+ E G+ LLE E V + + T+++E+
Sbjct: 3266 QQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERE--- 3322
Query: 1487 LLHVQKELSTALGE 1500
LH Q + S G+
Sbjct: 3323 -LHAQLQSSDGTGQ 3335
Score = 36.7 bits (81), Expect = 0.84
Identities = 70/405 (17%), Positives = 166/405 (40%), Gaps = 23/405 (5%)
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSA---GSNTTARRSLTTNSNKLAEERVKVLEDEI 786
EL+ E+ K +++E++S + + A S+ T + S L +E K LE++
Sbjct: 3298 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKH 3357
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+ + L E E+ +L + + Q + + ++L + N + ++++ ++ +
Sbjct: 3358 SRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3415
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L+ + + KL E ++LQ + ++ + +L ++ + L + L +
Sbjct: 3416 LQRQLEEKRQQVYKLDLEGQRLQGI-----MQEFQKQELEREEKRESRRILYQNLNEPTT 3470
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
+ ++ + E KE++ K + Q L+
Sbjct: 3471 WSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKL-QCVASKLQV 3529
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
QK+ + R+ + D + +++ ++++ ++ ++ T+ L +
Sbjct: 3530 LPQKASE-RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTER 3588
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALE-- 1077
+ ++L+ + S+ T EKN L+ + KL++ A + N +E
Sbjct: 3589 LLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAI 3648
Query: 1078 --NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+E + + TL + +K EA++ KL A+L+N + LQT D
Sbjct: 3649 IASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 3693
Score = 33.9 bits (74), Expect = 6.0
Identities = 42/227 (18%), Positives = 98/227 (43%), Gaps = 20/227 (8%)
Query: 348 REIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQD 407
RE ESE +PS E I+Q ++++L + + D +++++L ++
Sbjct: 3111 REQESE---KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKS 3167
Query: 408 NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPD 467
+ + + ++L+ + + +K ++K + L A +KK E+ +
Sbjct: 3168 ELAQTKLELETTLKAQ-HKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALE 3226
Query: 468 GMQRE-NRIKELEQEVARSTEVALRLQRE-------LAEANSKFTGSNPSLMKVPQPETV 519
+ + R +E ++E + +L Q++ L E + N S K+ +
Sbjct: 3227 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL--NESQQKIESQRML 3284
Query: 520 KVSRSSLTRGGSQEDPAQL------LRDLQDSLEREADLREQLRNAE 560
++ S +G + E L +R++ +L+RE +L QL++++
Sbjct: 3285 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSD 3331
>AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein.
Length = 3911
Score = 78.6 bits (185), Expect = 2e-13
Identities = 182/874 (20%), Positives = 362/874 (41%), Gaps = 87/874 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
DEK E E +++ EQE +++ELE +++ ++++ +EL S+ K A
Sbjct: 1941 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLSRQKEAMKAEA 1999
Query: 758 GSNTTARRSLTTNSNKLAEERVKV---LEDEIDEVRKKLIEKERDCE-RLHAELSLAQKK 813
G + L + KL +E+++V E D+++K++ E D E ++ + L Q+K
Sbjct: 2000 GP---VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK 2056
Query: 814 PKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLK 872
L+ R QQN L++QL E+ L + E + + Q E +KL Q LK
Sbjct: 2057 NTELMDLR------QQNQALEKQL---EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2107
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
R + T++ QL N LKE K EL + + + + + R E K E
Sbjct: 2108 VVP--RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 2165
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTT-KLQLK 990
+ +Q L + Q ++ + I +K ++T + QL+
Sbjct: 2166 RELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2225
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKE-------IDEIRSKLSKNDSEFT 1042
+ E+LE + E+ + + KE T + + LE+E ++++ + ++D+ T
Sbjct: 2226 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2285
Query: 1043 NEKNRL-----------QTEIAKLKDVNAKLEGDKDVFANKYKALENENS---NLSNQCK 1088
+++ L + EI +L + KL+ + + K +E +N +L Q +
Sbjct: 2286 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN-KVIEEKNELIRDLETQIE 2344
Query: 1089 TLTEEM----KNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
L + +NRE +I +L+ ++ LQ +++
Sbjct: 2345 CLMSDQECVKRNREEEIEQLNEVIEK---LQQELANI---GQKTSMNAHSLSEEADSLKH 2398
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQL-STRKDRVTXXXX 1203
Q+D + +K L ++V +++ ++ ++L S +++R +
Sbjct: 2399 QLD---VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKI 2455
Query: 1204 XXXXXXXQAVVLANTHR-RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKI 1262
V + + + + +E+ +D L++ ++ ++ F + E + + E ++
Sbjct: 2456 QSIPENSVNVAIDHLSKDKPELEVVLTEDALKS--LENQTYFKSFEENGKGSIINLETRL 2513
Query: 1263 TSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQDEL 1321
LEST++AKD+ + Q ++ +++ ++V ++ Q +L
Sbjct: 2514 LQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL 2573
Query: 1322 NNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELD 1381
+ + + + + +L +L S E++ E+
Sbjct: 2574 EAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI--SELESQVVEMH 2631
Query: 1382 TDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
T L E+++++ IA +K+V K+ +L L+ L+ E+ K+ + E +T
Sbjct: 2632 TSLILEKEQVE---IA-EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTT 2687
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQA---QGELL-------HVQ 1491
+L HS E + EL E L E V TKA L KE+A Q ELL +Q
Sbjct: 2688 TELFHSNE-ESGFFNEL----EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQ 2742
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
K+LS + +EKL S ++TE+Q S
Sbjct: 2743 KDLSQVRDHLAEAKEKL---SILEKEDETEVQES 2773
Score = 70.5 bits (165), Expect = 6e-11
Identities = 142/682 (20%), Positives = 289/682 (42%), Gaps = 70/682 (10%)
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR----ENRIKELEQEVARSTEVALRL 492
++ ++E Q E E+ E + + + G +G+Q+ E IK+ + + + T +
Sbjct: 170 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 229
Query: 493 QRELAEANSKF---TGSNPSLM----KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
+RE E +F T + L ++ ET++ S S T + Q+L Q
Sbjct: 230 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH-QQQ 288
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
LE + L E + +E+ Q+ +FL +++ ++E E Q+K +
Sbjct: 289 LEEQDHLLEDYQKKKEDFT--MQI---SFLQEKI--------KVYEME------QDKKVE 329
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
++ +EK K EE + +L L++ + ++ +++
Sbjct: 330 NSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 389
Query: 666 LQLKKMATKAR-SRKLSPTPPANKLSIETANDNDEK-ETDEADPAEMKLLLELNEQEATV 723
L+L K R S + ++ N D + ETD E + +L + A +
Sbjct: 390 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 449
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
+++ Q K+ L +++ +++ + G A RS + + + E+++K++
Sbjct: 450 DEMYGQQIVQMKQEL---IRQHMAQMEEMKTRHKGEMENALRSYSNIT--VNEDQIKLMN 504
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
I+E+ KL + E+L EL L ++ L R L+ DL +L ++
Sbjct: 505 VAINELNIKLQDTNSQKEKLKEELGLILEEKCAL--QRQLE-------DLVEELSFSREQ 555
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ RA+ Q++ KL +K L +++ L+++ ++K +L++E + K
Sbjct: 556 --IQRAR-QTIAEQESKLNEAHKSLSTVED---LKAEIVSASESRKELELKHEAEVTNYK 609
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
IK LEM+ + EK+ R E+ + E + L++ Q + ++
Sbjct: 610 IK-LEML-EKEKNAVLDRMAESQEAELERLRT-QLLFSHEEELSKLKEDLEIEHRINIEK 666
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED--------LECEIGEMYVVMKN-AGLSG 1014
LKD+ +K +I +++ K++ + +D L EI ++ + ++
Sbjct: 667 LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS 726
Query: 1015 KEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+EMT + +L+KEI+ +R + K E LQ + L+ + E D K+
Sbjct: 727 EEMTLQINELQKEIEILRQE-EKEKGTLEQEVQELQLKTELLEKQMKEKEND---LQEKF 782
Query: 1074 KALENENSNLSNQCKTLTEEMK 1095
LE ENS L ++ KTL + +K
Sbjct: 783 AQLEAENSILKDEKKTLEDMLK 804
Score = 62.1 bits (144), Expect = 2e-08
Identities = 130/691 (18%), Positives = 286/691 (41%), Gaps = 59/691 (8%)
Query: 267 KEYQDQIEGLKQEVDILR-KRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+++ QI L++++ + ++ ++VE + + + I+ N + L+L+ K
Sbjct: 304 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 363
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
LTT ++ L + ++ + QK +EI++ +LE S + + + E+++ + E L +
Sbjct: 364 ---LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 420
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++ ++ + + R + + Y +++Q + + + KT K
Sbjct: 421 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 480
Query: 445 ADQLEQEKA-------EHEKKLLEIVGGPDG--MQRENRIKE-LEQEVARSTEVALRLQR 494
+ ++ E + KL+ + +Q N KE L++E+ E LQR
Sbjct: 481 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 540
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L + + + S + + Q T+ S L + DL+ + ++ R+
Sbjct: 541 QLEDLVEELSFSREQIQRARQ--TIAEQESKLNEAHKS---LSTVEDLKAEIVSASESRK 595
Query: 555 QLR-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
+L E E N K +K + D + E ++ +++ + SK
Sbjct: 596 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA----ESQEAELERLRTQLLFSHEEELSK 651
Query: 614 EKSD---SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
K D ++I+K + H+ + N M+ + + E+DN
Sbjct: 652 LKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ---KIETMQFEKDN--------- 699
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEATVLRRKVE 729
+ TK +++ + L N E+ T + + + ++ +L E+E L ++V+
Sbjct: 700 LITK-QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ 758
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL-------AEERVKVL 782
EL+ E L+KQ+KE + + N+ + T + L EER+ L
Sbjct: 759 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 818
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQ---KKPKTLIKSRSLDASDQQNVDLKRQLQV 839
+ + + + EKE + + L Q + + + K R+ + ++N ++ Q ++
Sbjct: 819 DSIKSKSKDSVWEKEIEI-LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-EL 876
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENK-KLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
E+ A +L+ K LE K + E K KL+ L + L + K + + +E K
Sbjct: 877 QEEYACLLKVK-DDLEDSKNKQELEYKSKLKALN--EELHLQRINPTTVKMKSSVFDEDK 933
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKE 929
+A+ E+ + + + +E + E TK+E
Sbjct: 934 TFVAETLEMGEVVEKDTTELMEKL-EVTKRE 963
Score = 56.0 bits (129), Expect = 1e-06
Identities = 150/836 (17%), Positives = 344/836 (41%), Gaps = 65/836 (7%)
Query: 290 VEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIRE 349
++ E +++L + + A + SE Q + T E +R+ + +
Sbjct: 1847 IDPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATES 1904
Query: 350 IESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNF 409
++ + E R ++R EQL +L AE + + DE ++++++ ++
Sbjct: 1905 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1964
Query: 410 REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGM 469
++ L E +Q + +LS + + + +A +EQ+ + +KL++ + +
Sbjct: 1965 L-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK-----EKL 2018
Query: 470 QRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG 529
+ + + +++ ++ + + L+ ++ E S+F L + E + + + +
Sbjct: 2019 EVQCQAEKVRDDLQKQVKA---LEIDVEEQVSRFI----ELEQEKNTELMDLRQQNQALE 2071
Query: 530 GSQEDPAQLLRDLQDSLEREADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD 588
E + L + E E D+ +++++ E++ K V P F Q ++++
Sbjct: 2072 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ---LKVV--PRF---QPISEH----Q 2119
Query: 589 IHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQ-FHFDLPYLSIFNHMAA 647
E E + N ++ K + SKE+ I + EE + F + L ++A
Sbjct: 2120 TREVEQLANHLKEKTDKCSELLLSKEQLQR---DIQERNEEIEKLEFRVRELEQALLVSA 2176
Query: 648 NNLRKTAAR----VEEDNESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKET 702
+ +K R E L L+++ A + A RK L + +E E
Sbjct: 2177 DTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK---EKEITNLEEQLEQFREELEN 2233
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEE----LEQDKEALKKQVKELTSKISSVTKTSAG 758
+ ++ + LE+ ++E+T +++E+ + D E L +KE + + G
Sbjct: 2234 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2293
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCER-LHAELSLAQKKPKTL 817
+ ++L E+ K+ + K+IE++ + R L ++ + +
Sbjct: 2294 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 2353
Query: 818 IKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAKS 876
++R +++ L ++ ++QE + + KT S+ A + + ++ K QL + A+
Sbjct: 2354 KRNR-----EEEIEQLNEVIEKLQQELANIGQKT-SMNAHSLSEEADSLKHQLDVVIAEK 2407
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
L ++ ++ ++ T ++N LKE K+ +L Q+ S K+ R E+ +K ++
Sbjct: 2408 LALEQQVETANEEMTFMKNVLKETNFKMNQL---TQELFSLKRER--ESVEK-IQSIPEN 2461
Query: 937 QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTTK-LQLKKMVE 994
+ LKSL++ KSF+ +L T+ LQL+ V
Sbjct: 2462 SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVS 2521
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT--EI 1052
+ E+ + Y +K+ G+ T L+K+I ++ + + + + +L+ E
Sbjct: 2522 AKDLELTQCYKQIKDMQEQGQFET--EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 2579
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
AK N + + + N + L + LT + E+Q+ ++ L
Sbjct: 2580 AKFCQDNQTISSEPE-RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSL 2634
Score = 55.2 bits (127), Expect = 2e-06
Identities = 149/790 (18%), Positives = 330/790 (41%), Gaps = 65/790 (8%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT--RQIEQLRAKLLAAETL 380
+Q + TH E + E +I E+ ELE T +Q+++ A + + +
Sbjct: 159 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 218
Query: 381 CEELMD-------ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKNCR 432
+L E ++ +E +L +Q F++ QA E +LR T +
Sbjct: 219 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASE--TLRNSTHSSTAADLL 276
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ +++ ++ + +++KK + +Q + ++ E+EQ+ +V
Sbjct: 277 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----KKVENSN 332
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+ E+ E + N +++ + +T+++ + LT +LL +LQ+ + ++
Sbjct: 333 KEEIQEKETIIEELNTKIIE-EEKKTLEL-KDKLTTAD------KLLGELQEQIVQK--- 381
Query: 553 REQLRNAEEETANCKQVNPPTFLD-KQVM-TDNIVTCDIHESETVTNSIQNKMIHAASTP 610
++++N + E N KQ + + KQ+M T + H+ I +M
Sbjct: 382 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 441
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ +++ + + + Q +L I HMA KT + E +N L
Sbjct: 442 LEQLRAELDEMYGQQIVQMKQ---EL----IRQHMAQMEEMKTRHKGEMENA--LRSYSN 492
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ KL N+L+I+ + N +KE + E+ L+LE L VEE
Sbjct: 493 ITVNEDQIKLMNVA-INELNIKLQDTNSQKEKLKE---ELGLILEEKCALQRQLEDLVEE 548
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTA--RRSLTTNSNKLAEERVKVLEDEIDE 788
L +E +++ + + + S + + +T + + + S E +K E E+
Sbjct: 549 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKH-EAEVTN 607
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
+ KL E++ + ++ +Q+ ++++ L + +++ LK L+ IE ++ +
Sbjct: 608 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEK 666
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
K + K Q + + ++ + ++++ +K +L TK +N+L ++K+K+L+
Sbjct: 667 LKDNL--GIHYKQQIDGLQNEMSQKIETMQFEKD-NLITK-----QNQLILEISKLKDLQ 718
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ KSE+ +KE + L+ ++ + +K ++D
Sbjct: 719 QSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDL 778
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
Q+ F + K L+ M++ E ++ + S K + + EKEI
Sbjct: 779 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD---SIKSKSKDSVWEKEI- 834
Query: 1029 EIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
EI L + + + + +L EI K ++ + E + +V Y+ L+ E + L + K
Sbjct: 835 EI---LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLL-KVK 887
Query: 1089 TLTEEMKNRE 1098
E+ KN++
Sbjct: 888 DDLEDSKNKQ 897
Score = 53.6 bits (123), Expect = 7e-06
Identities = 84/413 (20%), Positives = 167/413 (40%), Gaps = 32/413 (7%)
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTS-KISSVTKTSAGSNTTARRSLTT 769
KLL ++E + + KV + E +E+ +++ + S K + + AR L
Sbjct: 1868 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1927
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
+K AE + DE +++ EK +RL EL A + + L ++QQ
Sbjct: 1928 ELSK-AEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL-------EAEQQ 1979
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ +R+L ++EA ++A+ +E ++L E +KL K +++K D K+
Sbjct: 1980 QIQEERELLSRQKEA--MKAEAGPVE---QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ 2034
Query: 890 TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXX 949
LE +++E +++ ELE EK + ++ K +
Sbjct: 2035 VKALEIDVEEQVSRFIELEQ-------EKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2087
Query: 950 XXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMK 1008
Q ++ L+ Q PR T ++ QL +++ + E+ + +
Sbjct: 2088 REHERDVFQQEIQKLEQ--QLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2145
Query: 1009 NAGLSGKEMTAKT-KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK---DVNAKLEG 1064
+E + KLE + E+ L + F ++R + K + +L+
Sbjct: 2146 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQA 2205
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
++D K E E +NL Q + EE++N+ ++ +L L+ TT
Sbjct: 2206 ERDAIDRK----EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2254
Score = 51.2 bits (117), Expect = 4e-05
Identities = 133/710 (18%), Positives = 295/710 (41%), Gaps = 66/710 (9%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
+ Q Q++ L+ +V+ R +E+EK+ L+ + ++ K+++ ++
Sbjct: 2030 DLQKQVKALEIDVEEQVSRFIELEQEKNTELM-------DLRQQNQALEKQLEKMRKFLD 2082
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELET----RPSTEAQTRQIEQLRAKLLAAETLCEE 383
E E RD Q+I+++E +L+ +P +E QTR++EQL L C E
Sbjct: 2083 EQAIDREHERDV---FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2139
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
L+ E +++++++ ++ FR + ++ + + Q +++ + K E
Sbjct: 2140 LLLSKEQLQRDIQERNEEIEKLE--FRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 2197
Query: 444 KAD-QLEQEKAEHEKKLLEIVGGPDGMQR-----ENRIKELEQ-----EVARSTEVALRL 492
+ QL+ E+ ++K EI + +++ EN+ +E++Q E+ + E RL
Sbjct: 2198 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK-ESTTRL 2256
Query: 493 QRELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
Q EL + N F L + + + + + + G + + ++ E+
Sbjct: 2257 Q-ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2315
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQV---MTDNIVTC-----DIHESETVTNSIQNKM 603
L++QL+ + ++ L+ Q+ M+D +I + V +Q ++
Sbjct: 2316 LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQEL 2375
Query: 604 IH-----AASTPSSKEKSDSPPLSIDKT-TEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+ + + S E++DS +D E+ + + N L++T ++
Sbjct: 2376 ANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKM 2435
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKE---TDEA-----DPAE 709
+ + L LK+ + P N + D E E T++A +
Sbjct: 2436 NQLTQE-LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2494
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
K E + L ++ +LE A ++ + +I + + ++ +
Sbjct: 2495 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI-V 2553
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLI-EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
N K+ EE KV + +++ + + E + C+ +++ + +T I++ + D+
Sbjct: 2554 NLQKIVEE--KVAAALVSQIQLEAVQEYAKFCQ---DNQTISSEPERTNIQNLNQLREDE 2608
Query: 829 QNVDLKR-QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
D+ L++ E E+ V+ T SL + E+++ K + L K K L K L+ N
Sbjct: 2609 LGSDISALTLRISELESQVVEMHT-SLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNE 2666
Query: 888 KKTTQLENELKEALAKIKELEMICQ-DEKSEKKVRFTEATKKETDTLKSK 936
KK Q E E K + ++ L+ + +E+ F E +++ +K
Sbjct: 2667 KK--QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2714
Score = 50.8 bits (116), Expect = 5e-05
Identities = 127/686 (18%), Positives = 284/686 (41%), Gaps = 55/686 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ ++++++++E +EV L + E +KE + RL ++ NK ++
Sbjct: 2220 LEEQLEQFREELENKNEEVQQLHMQLEIQKKEST----TRLQELEQENKLFKDDMEKLGL 2275
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
++ + ++T ++ + K Q I+E E E++ Q +++Q + K+ +
Sbjct: 2276 AIKESDAMSTQDQHVLFGK--FAQIIQEKEVEID---QLNEQVTKLQQ-QLKITTDNKVI 2329
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKLKK 440
EE + D++ ++ L ++ N RE++ ++ + + +L+Q + N + S
Sbjct: 2330 EEKNELIRDLETQIECLMSDQECVKRN-REEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2388
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAEA 499
+AD L K + + + E + ++ N + V + T + +L +EL
Sbjct: 2389 LSEEADSL---KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2445
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
+ S + +P+ +V V+ L++ E L D SLE + + N
Sbjct: 2446 KRE-RESVEKIQSIPE-NSVNVAIDHLSK-DKPELEVVLTEDALKSLENQTYFKSFEENG 2502
Query: 560 EEETANCK----QVNPPTFLDKQVMTDNIVTC-DIHE-SETVTNSIQNKMIHAASTPSSK 613
+ N + Q+ +T D+ E + T +Q K+++ K
Sbjct: 2503 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2562
Query: 614 EKSD-SPPLSIDKTTEETQFHFDLPYLSI----FNHMAANNLRKTAARVEEDNESLLLQL 668
+ + ++ E +F D +S N N LR+ + D +L L++
Sbjct: 2563 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED--ELGSDISALTLRI 2620
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
++ ++ S K +E A N ++ E E++ LLE NE +K
Sbjct: 2621 SELESQVVEMHTSLI--LEKEQVEIAEKNVLEK--EKKLLELQKLLEGNE-------KKQ 2669
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
E E+ + +V + T+++ + S N + + K AE + +++ ++
Sbjct: 2670 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK-AE--LASYKEKAEK 2726
Query: 789 VRKKLIEKERDCERLHAELS-----LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
++++L+ KE + L +LS LA+ K K I L+ D+ V ++ + E
Sbjct: 2727 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSI----LEKEDETEVQESKKACMFEPL 2782
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
L S K+ + N+ Q+L ++ + + ++++ T++ ++ E + K
Sbjct: 2783 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 2842
Query: 904 IKELEMICQDEKSEKKVRFTEATKKE 929
++EL + + + TE K+E
Sbjct: 2843 MQELHAAEILDMESRHISETETLKRE 2868
Score = 50.0 bits (114), Expect = 8e-05
Identities = 128/666 (19%), Positives = 265/666 (39%), Gaps = 57/666 (8%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
E LQ+++ +L R++ + Q I E ES+L +E L+A++++A
Sbjct: 534 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN---EAHKSLSTVEDLKAEIVSA 590
Query: 378 ETLCEELMDENE----DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN-CR 432
+EL ++E + K +L L + D E Q E LR +L + +
Sbjct: 591 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 650
Query: 433 VLSFKLKKTER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
L L+ R ++L+ H K+ ++ + + E E + + + ++ L
Sbjct: 651 KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 710
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPET---VKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
+ + L + S M + E +++ R G+ E Q L+ + LE+
Sbjct: 711 ISK-LKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 769
Query: 549 -----EADLREQLRNAEEETANCKQVNPPTFLDKQVMT-----DNIVTCDIHESETVTNS 598
E DL+E+ E E + K ++ T + ++ D +S++ +S
Sbjct: 770 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKS-KDS 828
Query: 599 IQNKMIHAASTPSSKEKSDSPPLS--IDKTTEETQF---HFDLPYLSIFNHMAANNLRKT 653
+ K I + K L+ I+K F +F++ Y + A L K
Sbjct: 829 VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC--LLKV 886
Query: 654 AARVEEDNESLLLQ----LKKMATKARSRKLSPTPPANKLSIE------TANDNDEKETD 703
+E+ L+ LK + + ++++PT K S+ A + E
Sbjct: 887 KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVV 946
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
E D E+ LE+ ++E L +++ +L + + ++ L ++ S+ + +
Sbjct: 947 EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRC 1006
Query: 764 RR-SLTTNSNKL-----AEERVKVLEDEIDEVRKKLIEKE-RDCERLHAELSLAQKKPKT 816
R + N N+ + +V L D + + + E + E S + K
Sbjct: 1007 RELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV 1066
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLK 872
++ ++ +Q + L + +E+S LRA S L+ + L++E L+L
Sbjct: 1067 SFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPSENDKLQKELNVLKSEQNDLRLQM 1125
Query: 873 NAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
A+ + + + + +ENE +AL +KE + Q+EK ++ + + E
Sbjct: 1126 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL---ELQ 1182
Query: 932 TLKSKQ 937
T+K+++
Sbjct: 1183 TMKTQE 1188
Score = 44.8 bits (101), Expect = 0.003
Identities = 74/358 (20%), Positives = 155/358 (43%), Gaps = 27/358 (7%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA----AKD---VHIKQLE- 1280
EKDE F++ + L+ + + L+A + ++ ST A AK H +QLE
Sbjct: 232 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 291
Query: 1281 -DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
D L + K ++ T + ++ + + N +I+ ++T E K
Sbjct: 292 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKV--ENSNKEEIQEKETIIEELNTK 349
Query: 1340 LEMAQLKS-DLA-KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-- 1395
+ + K+ +L KL + +N EL Q ER+ + ++
Sbjct: 350 IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQL 409
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI-TELKQEYEETVKKLEHSLALE 1451
+ + +KD++ T ++ +EQ + +++ EL + Y + + +++ L +
Sbjct: 410 MGTVEELQKRNHKDSQFET--DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQ 467
Query: 1452 K-AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ-KELSTALGEIKTLQEKLG 1509
A+ EE+ +++ E + + + +TV ++Q + L++V EL+ L + + +EKL
Sbjct: 468 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK--LMNVAINELNIKLQDTNSQKEKLK 525
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
E EK +Q + L E L +++RAR + ++E +L A+ +E
Sbjct: 526 EELGLILEEKCALQRQLEDLVEELSFSREQIQRAR--QTIAEQESKLNEAHKSLSTVE 581
Score = 44.4 bits (100), Expect = 0.004
Identities = 82/447 (18%), Positives = 182/447 (40%), Gaps = 25/447 (5%)
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK- 1434
+AK+ Q + ++ D + + K ++ +++ L+ K+K+ E + + +
Sbjct: 277 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 336
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
QE E +++L + E+ + EL K ++ + ++ + ++ + L +
Sbjct: 337 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSK 396
Query: 1495 STALGEIKTLQEKLGT--ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+ +++ +GT E N + ++ + I E+ E RA L+ Q+
Sbjct: 397 QKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 456
Query: 1553 ERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+++ R+ + + + Y ++ +
Sbjct: 457 IVQMKQELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ 515
Query: 1613 XXIEQSEKARK--AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
Q EK ++ I + K + Q+ + +EL Q+ R R+ + L A K
Sbjct: 516 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 575
Query: 1671 SMA---EIKNGDKSARIHRNSISSTDEEE---YRNKVALLEQQVACLEDELCESR-LLAS 1723
S++ ++K SA R + E E Y+ K+ +LE++ + D + ES+
Sbjct: 576 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 635
Query: 1724 KLNTELV---SEKSSAEVRLAEMQSRLN-EYEEERLLSSGRARVAGLATRME-----LAW 1774
+L T+L+ E+ S E++ R+N E ++ L + ++ GL M + +
Sbjct: 636 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 695
Query: 1775 HKER--DEQQRLLQETSTLARDLRQTL 1799
K+ +Q +L+ E S L +DL+Q+L
Sbjct: 696 EKDNLITKQNQLILEISKL-KDLQQSL 721
Score = 43.6 bits (98), Expect = 0.007
Identities = 144/720 (20%), Positives = 289/720 (40%), Gaps = 86/720 (11%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQK- 346
ER +EK+DI+ R + A+ +E ++Q++ L+ E ++ E + Q+
Sbjct: 1947 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL 2006
Query: 347 IREIESELETRPSTEAQTRQI-----EQLRAKLLAAETLCEELMDENEDMKKELRDLXXX 401
++E E ++ + + Q ++ +Q++A + E ++ ++ EL DL
Sbjct: 2007 LQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQ 2066
Query: 402 XXXMQDNF-------------REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
++ RE + D + ++LEQ +K + R+ +QL
Sbjct: 2067 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQL 2126
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRE-----NRIKELEQEVARSTEVALRLQRELAE--ANS 501
E K E++ + +QR+ I++LE V R E AL + + + +
Sbjct: 2127 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV-RELEQALLVSADTFQKVEDR 2185
Query: 502 KFTG---SNPSL-MKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
K G + P L ++V Q E + R +E Q +L++ E L QL
Sbjct: 2186 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2245
Query: 557 R-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI-HAASTPSSKE 614
+E T +++ L K M + I ES+ ++ Q+ + A KE
Sbjct: 2246 EIQKKESTTRLQELEQENKLFKDDMEK--LGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2303
Query: 615 -KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN------NLRKTAARVEEDNESLLLQ 667
+ D + K ++ + D + N + + L V+ + E + Q
Sbjct: 2304 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2363
Query: 668 LKKMATKARSR--KLSPTPPANKLSIETANDNDEKETDE--ADPAEMKLLLELNEQEATV 723
L ++ K + + N S+ D+ + + D A+ ++ +E +E T
Sbjct: 2364 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2423
Query: 724 LRR-------KVEELEQDKEALKKQVKELTSKISSVTKTSAG-SNTTARRSLTTNSNKLA 775
++ K+ +L Q+ +LK++ +E KI S+ + S + + L
Sbjct: 2424 MKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2482
Query: 776 EERVKVLEDE-------------IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
E+ +K LE++ I + +L++ E EL+ K+ K + +
Sbjct: 2483 EDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 2542
Query: 823 LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA---------DNEKLQTENKKLQLLKN 873
+ Q + Q V E+ A+ L ++ Q LEA DN+ + +E ++ ++N
Sbjct: 2543 FETEMLQKKIVNLQKIVEEKVAAALVSQIQ-LEAVQEYAKFCQDNQTISSEPERTN-IQN 2600
Query: 874 AKSLRSDK-ALDLN--TKKTTQLENELKE---ALAKIKELEMICQDEKSEKKVRFTEATK 927
LR D+ D++ T + ++LE+++ E +L KE I + EK+ + E K
Sbjct: 2601 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK 2660
Score = 41.1 bits (92), Expect = 0.039
Identities = 73/339 (21%), Positives = 145/339 (42%), Gaps = 26/339 (7%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
+ +EL+S KD R + + + + + + +LK++ LE+T+ A+ H+K+LE
Sbjct: 3140 MQVELSSMKD----RATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE- 3194
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
A R DK DE V + + Q L K KL ++E E +LE
Sbjct: 3195 AFRLEVKDKTDE----VHL--LNDTLASEQKKSRELQWALEKEKAKLGRSE-ERDKEELE 3247
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKEL--DTDLQSER-KKLDRMRIAH 1398
+ + K N S + +++ + D L E+ + L+ +
Sbjct: 3248 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLE 3307
Query: 1399 DKDVKNKDAELATLKGKLKI---LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEY 1455
+ V+ ++ +TL + ++ L+ + G G R L E+ +K+L+ L + +
Sbjct: 3308 SEKVRIREMS-STLDRERELHAQLQSSDGTGQSR-PPLPS--EDLLKELQKQLEEKHSRI 3363
Query: 1456 EELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
EL + E + + + T+ ++ ++ Q + L ++E +T G+ K + + E
Sbjct: 3364 VELLNETEKYKLDSLQTRQQMEKDR-QVHRKTLQTEQEANTE-GQKKMHELQSKVEDLQR 3421
Query: 1516 NTEKTEMQNSIASLQ-ERLCGGGWEVERARLNARLDQRE 1553
E+ Q L+ +RL G E ++ L R ++RE
Sbjct: 3422 QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELE-REEKRE 3459
Score = 39.9 bits (89), Expect = 0.091
Identities = 71/314 (22%), Positives = 144/314 (45%), Gaps = 27/314 (8%)
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD 703
H N + T R +E + L+ + +S+ L + + ++ ++
Sbjct: 3102 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3161
Query: 704 EADPAEMKLLLELNEQEA-TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ AE+K L + E T L+ + + L++ EA + +VK+ T ++ + T A
Sbjct: 3162 KMVVAELKSELAQTKLELETTLKAQHKHLKE-LEAFRLEVKDKTDEVHLLNDTLASEQKK 3220
Query: 763 ARR---SLTTNSNKL--AEERVKVLEDEIDEVRKKL-IEKERDCE---RLHAELSLAQKK 813
+R +L KL +EER K +E+++++ L +K+R+ + L + L +
Sbjct: 3221 SRELQWALEKEKAKLGRSEERDK---EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3277
Query: 814 PKTLIKSRSL-DA--SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE---KLQTENKK 867
+ + R L DA S++Q +L+ Q+ ++E E +R + +L+ + E +LQ+ +
Sbjct: 3278 QQKIESQRMLYDAQLSEEQGRNLELQV-LLESEKVRIREMSSTLDRERELHAQLQSSDGT 3336
Query: 868 LQL---LKNAKSLRS-DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
Q L + L+ K L+ + +L NE ++ K+ L+ Q EK + R T
Sbjct: 3337 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKT 3394
Query: 924 EATKKETDTLKSKQ 937
T++E +T K+
Sbjct: 3395 LQTEQEANTEGQKK 3408
Score = 39.5 bits (88), Expect = 0.12
Identities = 56/254 (22%), Positives = 114/254 (44%), Gaps = 24/254 (9%)
Query: 1260 NKITSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
++I +L + + + + +K+ +++ + + +Y+ +M+EM+ Q
Sbjct: 3096 SEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3155
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSD---LAKLENXXXXXXXXXXXXXXXS---S 1371
++L++ K+ + + ++E + KLE+ LK+ L +LE + +
Sbjct: 3156 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3215
Query: 1372 YWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRIT 1431
+ K++EL L+ E+ KL R DK+ EL LK L+ +Q + +
Sbjct: 3216 SEQKKSRELQWALEKEKAKLGRSE-ERDKE------ELEDLKFSLESQKQRNLQLNLLLE 3268
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGK----YELLEEEHV-VTKARLTVEKEQAQGE 1486
+ KQ E+ +K+E L A+ E G+ LLE E V + + T+++E+
Sbjct: 3269 QQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERE--- 3325
Query: 1487 LLHVQKELSTALGE 1500
LH Q + S G+
Sbjct: 3326 -LHAQLQSSDGTGQ 3338
Score = 36.7 bits (81), Expect = 0.84
Identities = 70/405 (17%), Positives = 166/405 (40%), Gaps = 23/405 (5%)
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSA---GSNTTARRSLTTNSNKLAEERVKVLEDEI 786
EL+ E+ K +++E++S + + A S+ T + S L +E K LE++
Sbjct: 3301 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKH 3360
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+ + L E E+ +L + + Q + + ++L + N + ++++ ++ +
Sbjct: 3361 SRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3418
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L+ + + KL E ++LQ + ++ + +L ++ + L + L +
Sbjct: 3419 LQRQLEEKRQQVYKLDLEGQRLQGI-----MQEFQKQELEREEKRESRRILYQNLNEPTT 3473
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
+ ++ + E KE++ K + Q L+
Sbjct: 3474 WSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKL-QCVASKLQV 3532
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
QK+ + R+ + D + +++ ++++ ++ ++ T+ L +
Sbjct: 3533 LPQKASE-RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTER 3591
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALE-- 1077
+ ++L+ + S+ T EKN L+ + KL++ A + N +E
Sbjct: 3592 LLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAI 3651
Query: 1078 --NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+E + + TL + +K EA++ KL A+L+N + LQT D
Sbjct: 3652 IASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 3696
Score = 33.9 bits (74), Expect = 6.0
Identities = 42/227 (18%), Positives = 98/227 (43%), Gaps = 20/227 (8%)
Query: 348 REIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQD 407
RE ESE +PS E I+Q ++++L + + D +++++L ++
Sbjct: 3114 REQESE---KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKS 3170
Query: 408 NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPD 467
+ + + ++L+ + + +K ++K + L A +KK E+ +
Sbjct: 3171 ELAQTKLELETTLKAQ-HKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALE 3229
Query: 468 GMQRE-NRIKELEQEVARSTEVALRLQRE-------LAEANSKFTGSNPSLMKVPQPETV 519
+ + R +E ++E + +L Q++ L E + N S K+ +
Sbjct: 3230 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL--NESQQKIESQRML 3287
Query: 520 KVSRSSLTRGGSQEDPAQL------LRDLQDSLEREADLREQLRNAE 560
++ S +G + E L +R++ +L+RE +L QL++++
Sbjct: 3288 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSD 3334
>AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein.
Length = 2058
Score = 78.6 bits (185), Expect = 2e-13
Identities = 182/874 (20%), Positives = 362/874 (41%), Gaps = 87/874 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
DEK E E +++ EQE +++ELE +++ ++++ +EL S+ K A
Sbjct: 139 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLSRQKEAMKAEA 197
Query: 758 GSNTTARRSLTTNSNKLAEERVKV---LEDEIDEVRKKLIEKERDCE-RLHAELSLAQKK 813
G + L + KL +E+++V E D+++K++ E D E ++ + L Q+K
Sbjct: 198 GP---VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK 254
Query: 814 PKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLK 872
L+ R QQN L++QL E+ L + E + + Q E +KL Q LK
Sbjct: 255 NTELMDLR------QQNQALEKQL---EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 305
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
R + T++ QL N LKE K EL + + + + + R E K E
Sbjct: 306 VVP--RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV 363
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTT-KLQLK 990
+ +Q L + Q ++ + I +K ++T + QL+
Sbjct: 364 RELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 423
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKE-------IDEIRSKLSKNDSEFT 1042
+ E+LE + E+ + + KE T + + LE+E ++++ + ++D+ T
Sbjct: 424 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 483
Query: 1043 NEKNRL-----------QTEIAKLKDVNAKLEGDKDVFANKYKALENENS---NLSNQCK 1088
+++ L + EI +L + KL+ + + K +E +N +L Q +
Sbjct: 484 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN-KVIEEKNELIRDLETQIE 542
Query: 1089 TLTEEM----KNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
L + +NRE +I +L+ ++ LQ +++
Sbjct: 543 CLMSDQECVKRNREEEIEQLNEVIEK---LQQELANI---GQKTSMNAHSLSEEADSLKH 596
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQL-STRKDRVTXXXX 1203
Q+D + +K L ++V +++ ++ ++L S +++R +
Sbjct: 597 QLD---VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKI 653
Query: 1204 XXXXXXXQAVVLANTHR-RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKI 1262
V + + + + +E+ +D L++ ++ ++ F + E + + E ++
Sbjct: 654 QSIPENSVNVAIDHLSKDKPELEVVLTEDALKS--LENQTYFKSFEENGKGSIINLETRL 711
Query: 1263 TSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQDEL 1321
LEST++AKD+ + Q ++ +++ ++V ++ Q +L
Sbjct: 712 LQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL 771
Query: 1322 NNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELD 1381
+ + + + + +L +L S E++ E+
Sbjct: 772 EAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI--SELESQVVEMH 829
Query: 1382 TDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
T L E+++++ IA +K+V K+ +L L+ L+ E+ K+ + E +T
Sbjct: 830 TSLILEKEQVE---IA-EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTT 885
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQA---QGELL-------HVQ 1491
+L HS E + EL E L E V TKA L KE+A Q ELL +Q
Sbjct: 886 TELFHSNE-ESGFFNEL----EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQ 940
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
K+LS + +EKL S ++TE+Q S
Sbjct: 941 KDLSQVRDHLAEAKEKL---SILEKEDETEVQES 971
Score = 56.0 bits (129), Expect = 1e-06
Identities = 150/836 (17%), Positives = 344/836 (41%), Gaps = 65/836 (7%)
Query: 290 VEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIRE 349
++ E +++L + + A + SE Q + T E +R+ + +
Sbjct: 45 IDPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATES 102
Query: 350 IESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNF 409
++ + E R ++R EQL +L AE + + DE ++++++ ++
Sbjct: 103 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 162
Query: 410 REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGM 469
++ L E +Q + +LS + + + +A +EQ+ + +KL++ + +
Sbjct: 163 L-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK-----EKL 216
Query: 470 QRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG 529
+ + + +++ ++ + + L+ ++ E S+F L + E + + + +
Sbjct: 217 EVQCQAEKVRDDLQKQVKA---LEIDVEEQVSRFI----ELEQEKNTELMDLRQQNQALE 269
Query: 530 GSQEDPAQLLRDLQDSLEREADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD 588
E + L + E E D+ +++++ E++ K V P F Q ++++
Sbjct: 270 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ---LKVV--PRF---QPISEH----Q 317
Query: 589 IHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQ-FHFDLPYLSIFNHMAA 647
E E + N ++ K + SKE+ I + EE + F + L ++A
Sbjct: 318 TREVEQLANHLKEKTDKCSELLLSKEQLQR---DIQERNEEIEKLEFRVRELEQALLVSA 374
Query: 648 NNLRKTAAR----VEEDNESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKET 702
+ +K R E L L+++ A + A RK L + +E E
Sbjct: 375 DTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK---EKEITNLEEQLEQFREELEN 431
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEE----LEQDKEALKKQVKELTSKISSVTKTSAG 758
+ ++ + LE+ ++E+T +++E+ + D E L +KE + + G
Sbjct: 432 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 491
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCER-LHAELSLAQKKPKTL 817
+ ++L E+ K+ + K+IE++ + R L ++ + +
Sbjct: 492 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 551
Query: 818 IKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAKS 876
++R +++ L ++ ++QE + + KT S+ A + + ++ K QL + A+
Sbjct: 552 KRNR-----EEEIEQLNEVIEKLQQELANIGQKT-SMNAHSLSEEADSLKHQLDVVIAEK 605
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
L ++ ++ ++ T ++N LKE K+ +L Q+ S K+ R E+ +K ++
Sbjct: 606 LALEQQVETANEEMTFMKNVLKETNFKMNQL---TQELFSLKRER--ESVEK-IQSIPEN 659
Query: 937 QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTTK-LQLKKMVE 994
+ LKSL++ KSF+ +L T+ LQL+ V
Sbjct: 660 SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVS 719
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT--EI 1052
+ E+ + Y +K+ G+ T L+K+I ++ + + + + +L+ E
Sbjct: 720 AKDLELTQCYKQIKDMQEQGQFET--EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 777
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
AK N + + + N + L + LT + E+Q+ ++ L
Sbjct: 778 AKFCQDNQTISSEPE-RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSL 832
Score = 53.6 bits (123), Expect = 7e-06
Identities = 84/413 (20%), Positives = 167/413 (40%), Gaps = 32/413 (7%)
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTS-KISSVTKTSAGSNTTARRSLTT 769
KLL ++E + + KV + E +E+ +++ + S K + + AR L
Sbjct: 66 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 125
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
+K AE + DE +++ EK +RL EL A + + L ++QQ
Sbjct: 126 ELSK-AEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL-------EAEQQ 177
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ +R+L ++EA ++A+ +E ++L E +KL K +++K D K+
Sbjct: 178 QIQEERELLSRQKEA--MKAEAGPVE---QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ 232
Query: 890 TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXX 949
LE +++E +++ ELE EK + ++ K +
Sbjct: 233 VKALEIDVEEQVSRFIELEQ-------EKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 285
Query: 950 XXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMK 1008
Q ++ L+ Q PR T ++ QL +++ + E+ + +
Sbjct: 286 REHERDVFQQEIQKLEQ--QLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 343
Query: 1009 NAGLSGKEMTAKT-KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK---DVNAKLEG 1064
+E + KLE + E+ L + F ++R + K + +L+
Sbjct: 344 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQA 403
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
++D K E E +NL Q + EE++N+ ++ +L L+ TT
Sbjct: 404 ERDAIDRK----EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 452
Score = 51.2 bits (117), Expect = 4e-05
Identities = 133/710 (18%), Positives = 295/710 (41%), Gaps = 66/710 (9%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
+ Q Q++ L+ +V+ R +E+EK+ L+ + ++ K+++ ++
Sbjct: 228 DLQKQVKALEIDVEEQVSRFIELEQEKNTELM-------DLRQQNQALEKQLEKMRKFLD 280
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELET----RPSTEAQTRQIEQLRAKLLAAETLCEE 383
E E RD Q+I+++E +L+ +P +E QTR++EQL L C E
Sbjct: 281 EQAIDREHERDV---FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 337
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
L+ E +++++++ ++ FR + ++ + + Q +++ + K E
Sbjct: 338 LLLSKEQLQRDIQERNEEIEKLE--FRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL 395
Query: 444 KAD-QLEQEKAEHEKKLLEIVGGPDGMQR-----ENRIKELEQ-----EVARSTEVALRL 492
+ QL+ E+ ++K EI + +++ EN+ +E++Q E+ + E RL
Sbjct: 396 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK-ESTTRL 454
Query: 493 QRELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
Q EL + N F L + + + + + + G + + ++ E+
Sbjct: 455 Q-ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 513
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQV---MTDNIVTC-----DIHESETVTNSIQNKM 603
L++QL+ + ++ L+ Q+ M+D +I + V +Q ++
Sbjct: 514 LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQEL 573
Query: 604 IH-----AASTPSSKEKSDSPPLSIDKT-TEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+ + + S E++DS +D E+ + + N L++T ++
Sbjct: 574 ANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKM 633
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKE---TDEA-----DPAE 709
+ + L LK+ + P N + D E E T++A +
Sbjct: 634 NQLTQE-LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 692
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
K E + L ++ +LE A ++ + +I + + ++ +
Sbjct: 693 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI-V 751
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLI-EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
N K+ EE KV + +++ + + E + C+ +++ + +T I++ + D+
Sbjct: 752 NLQKIVEE--KVAAALVSQIQLEAVQEYAKFCQ---DNQTISSEPERTNIQNLNQLREDE 806
Query: 829 QNVDLKR-QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
D+ L++ E E+ V+ T SL + E+++ K + L K K L K L+ N
Sbjct: 807 LGSDISALTLRISELESQVVEMHT-SLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNE 864
Query: 888 KKTTQLENELKEALAKIKELEMICQ-DEKSEKKVRFTEATKKETDTLKSK 936
KK Q E E K + ++ L+ + +E+ F E +++ +K
Sbjct: 865 KK--QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 912
Score = 50.8 bits (116), Expect = 5e-05
Identities = 127/686 (18%), Positives = 284/686 (41%), Gaps = 55/686 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ ++++++++E +EV L + E +KE + RL ++ NK ++
Sbjct: 418 LEEQLEQFREELENKNEEVQQLHMQLEIQKKEST----TRLQELEQENKLFKDDMEKLGL 473
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
++ + ++T ++ + K Q I+E E E++ Q +++Q + K+ +
Sbjct: 474 AIKESDAMSTQDQHVLFGK--FAQIIQEKEVEID---QLNEQVTKLQQ-QLKITTDNKVI 527
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKLKK 440
EE + D++ ++ L ++ N RE++ ++ + + +L+Q + N + S
Sbjct: 528 EEKNELIRDLETQIECLMSDQECVKRN-REEEIEQLNEVIEKLQQELANIGQKTSMNAHS 586
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAEA 499
+AD L K + + + E + ++ N + V + T + +L +EL
Sbjct: 587 LSEEADSL---KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 643
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
+ S + +P+ +V V+ L++ E L D SLE + + N
Sbjct: 644 KRE-RESVEKIQSIPE-NSVNVAIDHLSK-DKPELEVVLTEDALKSLENQTYFKSFEENG 700
Query: 560 EEETANCK----QVNPPTFLDKQVMTDNIVTC-DIHE-SETVTNSIQNKMIHAASTPSSK 613
+ N + Q+ +T D+ E + T +Q K+++ K
Sbjct: 701 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 760
Query: 614 EKSD-SPPLSIDKTTEETQFHFDLPYLSI----FNHMAANNLRKTAARVEEDNESLLLQL 668
+ + ++ E +F D +S N N LR+ + D +L L++
Sbjct: 761 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED--ELGSDISALTLRI 818
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
++ ++ S K +E A N ++ E E++ LLE NE +K
Sbjct: 819 SELESQVVEMHTSLI--LEKEQVEIAEKNVLEK--EKKLLELQKLLEGNE-------KKQ 867
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
E E+ + +V + T+++ + S N + + K AE + +++ ++
Sbjct: 868 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK-AE--LASYKEKAEK 924
Query: 789 VRKKLIEKERDCERLHAELS-----LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
++++L+ KE + L +LS LA+ K K I L+ D+ V ++ + E
Sbjct: 925 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSI----LEKEDETEVQESKKACMFEPL 980
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
L S K+ + N+ Q+L ++ + + ++++ T++ ++ E + K
Sbjct: 981 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 1040
Query: 904 IKELEMICQDEKSEKKVRFTEATKKE 929
++EL + + + TE K+E
Sbjct: 1041 MQELHAAEILDMESRHISETETLKRE 1066
Score = 43.6 bits (98), Expect = 0.007
Identities = 144/720 (20%), Positives = 289/720 (40%), Gaps = 86/720 (11%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQK- 346
ER +EK+DI+ R + A+ +E ++Q++ L+ E ++ E + Q+
Sbjct: 145 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL 204
Query: 347 IREIESELETRPSTEAQTRQI-----EQLRAKLLAAETLCEELMDENEDMKKELRDLXXX 401
++E E ++ + + Q ++ +Q++A + E ++ ++ EL DL
Sbjct: 205 LQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQ 264
Query: 402 XXXMQDNF-------------REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
++ RE + D + ++LEQ +K + R+ +QL
Sbjct: 265 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQL 324
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRE-----NRIKELEQEVARSTEVALRLQRELAE--ANS 501
E K E++ + +QR+ I++LE V R E AL + + + +
Sbjct: 325 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV-RELEQALLVSADTFQKVEDR 383
Query: 502 KFTG---SNPSL-MKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
K G + P L ++V Q E + R +E Q +L++ E L QL
Sbjct: 384 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 443
Query: 557 R-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI-HAASTPSSKE 614
+E T +++ L K M + I ES+ ++ Q+ + A KE
Sbjct: 444 EIQKKESTTRLQELEQENKLFKDDMEK--LGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 501
Query: 615 -KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN------NLRKTAARVEEDNESLLLQ 667
+ D + K ++ + D + N + + L V+ + E + Q
Sbjct: 502 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 561
Query: 668 LKKMATKARSR--KLSPTPPANKLSIETANDNDEKETDE--ADPAEMKLLLELNEQEATV 723
L ++ K + + N S+ D+ + + D A+ ++ +E +E T
Sbjct: 562 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 621
Query: 724 LRR-------KVEELEQDKEALKKQVKELTSKISSVTKTSAG-SNTTARRSLTTNSNKLA 775
++ K+ +L Q+ +LK++ +E KI S+ + S + + L
Sbjct: 622 MKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 680
Query: 776 EERVKVLEDE-------------IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
E+ +K LE++ I + +L++ E EL+ K+ K + +
Sbjct: 681 EDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 740
Query: 823 LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA---------DNEKLQTENKKLQLLKN 873
+ Q + Q V E+ A+ L ++ Q LEA DN+ + +E ++ ++N
Sbjct: 741 FETEMLQKKIVNLQKIVEEKVAAALVSQIQ-LEAVQEYAKFCQDNQTISSEPERTN-IQN 798
Query: 874 AKSLRSDK-ALDLN--TKKTTQLENELKE---ALAKIKELEMICQDEKSEKKVRFTEATK 927
LR D+ D++ T + ++LE+++ E +L KE I + EK+ + E K
Sbjct: 799 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK 858
Score = 41.1 bits (92), Expect = 0.039
Identities = 73/339 (21%), Positives = 145/339 (42%), Gaps = 26/339 (7%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
+ +EL+S KD R + + + + + + +LK++ LE+T+ A+ H+K+LE
Sbjct: 1346 MQVELSSMKD----RATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE- 1400
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
A R DK DE V + + Q L K KL ++E E +LE
Sbjct: 1401 AFRLEVKDKTDE----VHL--LNDTLASEQKKSRELQWALEKEKAKLGRSE-ERDKEELE 1453
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKEL--DTDLQSER-KKLDRMRIAH 1398
+ + K N S + +++ + D L E+ + L+ +
Sbjct: 1454 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLE 1513
Query: 1399 DKDVKNKDAELATLKGKLKI---LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEY 1455
+ V+ ++ +TL + ++ L+ + G G R L E+ +K+L+ L + +
Sbjct: 1514 SEKVRIREMS-STLDRERELHAQLQSSDGTGQSR-PPLPS--EDLLKELQKQLEEKHSRI 1569
Query: 1456 EELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
EL + E + + + T+ ++ ++ Q + L ++E +T G+ K + + E
Sbjct: 1570 VELLNETEKYKLDSLQTRQQMEKDR-QVHRKTLQTEQEANTE-GQKKMHELQSKVEDLQR 1627
Query: 1516 NTEKTEMQNSIASLQ-ERLCGGGWEVERARLNARLDQRE 1553
E+ Q L+ +RL G E ++ L R ++RE
Sbjct: 1628 QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELE-REEKRE 1665
Score = 39.9 bits (89), Expect = 0.091
Identities = 71/314 (22%), Positives = 144/314 (45%), Gaps = 27/314 (8%)
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD 703
H N + T R +E + L+ + +S+ L + + ++ ++
Sbjct: 1308 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 1367
Query: 704 EADPAEMKLLLELNEQEA-TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ AE+K L + E T L+ + + L++ EA + +VK+ T ++ + T A
Sbjct: 1368 KMVVAELKSELAQTKLELETTLKAQHKHLKE-LEAFRLEVKDKTDEVHLLNDTLASEQKK 1426
Query: 763 ARR---SLTTNSNKL--AEERVKVLEDEIDEVRKKL-IEKERDCE---RLHAELSLAQKK 813
+R +L KL +EER K +E+++++ L +K+R+ + L + L +
Sbjct: 1427 SRELQWALEKEKAKLGRSEERDK---EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 1483
Query: 814 PKTLIKSRSL-DA--SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE---KLQTENKK 867
+ + R L DA S++Q +L+ Q+ ++E E +R + +L+ + E +LQ+ +
Sbjct: 1484 QQKIESQRMLYDAQLSEEQGRNLELQV-LLESEKVRIREMSSTLDRERELHAQLQSSDGT 1542
Query: 868 LQL---LKNAKSLRS-DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
Q L + L+ K L+ + +L NE ++ K+ L+ Q EK + R T
Sbjct: 1543 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKT 1600
Query: 924 EATKKETDTLKSKQ 937
T++E +T K+
Sbjct: 1601 LQTEQEANTEGQKK 1614
Score = 39.5 bits (88), Expect = 0.12
Identities = 56/254 (22%), Positives = 114/254 (44%), Gaps = 24/254 (9%)
Query: 1260 NKITSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
++I +L + + + + +K+ +++ + + +Y+ +M+EM+ Q
Sbjct: 1302 SEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 1361
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSD---LAKLENXXXXXXXXXXXXXXXS---S 1371
++L++ K+ + + ++E + KLE+ LK+ L +LE + +
Sbjct: 1362 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 1421
Query: 1372 YWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRIT 1431
+ K++EL L+ E+ KL R DK+ EL LK L+ +Q + +
Sbjct: 1422 SEQKKSRELQWALEKEKAKLGRSE-ERDKE------ELEDLKFSLESQKQRNLQLNLLLE 1474
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGK----YELLEEEHV-VTKARLTVEKEQAQGE 1486
+ KQ E+ +K+E L A+ E G+ LLE E V + + T+++E+
Sbjct: 1475 QQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERE--- 1531
Query: 1487 LLHVQKELSTALGE 1500
LH Q + S G+
Sbjct: 1532 -LHAQLQSSDGTGQ 1544
Score = 36.7 bits (81), Expect = 0.84
Identities = 70/405 (17%), Positives = 166/405 (40%), Gaps = 23/405 (5%)
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSA---GSNTTARRSLTTNSNKLAEERVKVLEDEI 786
EL+ E+ K +++E++S + + A S+ T + S L +E K LE++
Sbjct: 1507 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKH 1566
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+ + L E E+ +L + + Q + + ++L + N + ++++ ++ +
Sbjct: 1567 SRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 1624
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L+ + + KL E ++LQ + ++ + +L ++ + L + L +
Sbjct: 1625 LQRQLEEKRQQVYKLDLEGQRLQGI-----MQEFQKQELEREEKRESRRILYQNLNEPTT 1679
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
+ ++ + E KE++ K + Q L+
Sbjct: 1680 WSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKL-QCVASKLQV 1738
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
QK+ + R+ + D + +++ ++++ ++ ++ T+ L +
Sbjct: 1739 LPQKASE-RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTER 1797
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALE-- 1077
+ ++L+ + S+ T EKN L+ + KL++ A + N +E
Sbjct: 1798 LLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAI 1857
Query: 1078 --NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+E + + TL + +K EA++ KL A+L+N + LQT D
Sbjct: 1858 IASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 1902
Score = 33.9 bits (74), Expect = 6.0
Identities = 42/227 (18%), Positives = 98/227 (43%), Gaps = 20/227 (8%)
Query: 348 REIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQD 407
RE ESE +PS E I+Q ++++L + + D +++++L ++
Sbjct: 1320 REQESE---KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKS 1376
Query: 408 NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPD 467
+ + + ++L+ + + +K ++K + L A +KK E+ +
Sbjct: 1377 ELAQTKLELETTLKAQ-HKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALE 1435
Query: 468 GMQRE-NRIKELEQEVARSTEVALRLQRE-------LAEANSKFTGSNPSLMKVPQPETV 519
+ + R +E ++E + +L Q++ L E + N S K+ +
Sbjct: 1436 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL--NESQQKIESQRML 1493
Query: 520 KVSRSSLTRGGSQEDPAQL------LRDLQDSLEREADLREQLRNAE 560
++ S +G + E L +R++ +L+RE +L QL++++
Sbjct: 1494 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSD 1540
>D86970-1|BAA13206.2| 2067|Homo sapiens KIAA0216 protein.
Length = 2067
Score = 78.2 bits (184), Expect = 3e-13
Identities = 148/773 (19%), Positives = 316/773 (40%), Gaps = 59/773 (7%)
Query: 299 LRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETR 357
+R L + + + + E+ +L+ K+ + +LR L +I E+ SEL + R
Sbjct: 1256 VRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 1315
Query: 358 PSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDL------XXXXXXMQDNFRE 411
+ E+ ++ ++ A+ L AE +EL + + +KK++ + + N
Sbjct: 1316 NTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEV 1375
Query: 412 DQADEYSSLRRELEQTIKNCRVLSFKLKKT-ERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
D D R + E+ ++ +L++ E K + +Q K + E++L ++ D +
Sbjct: 1376 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQA--DSEE 1433
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGG 530
+ +++L+++ RL EL + G +V E K R +
Sbjct: 1434 SQRALQQLKKK-------CQRLTAELQDTKLHLEG-----QQVRNHELEKKQRRFDSELS 1481
Query: 531 SQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
+ AQ + ++ L+RE D+ + ++ K ++ F K V + + DI
Sbjct: 1482 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ-DIS 1540
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTT----EETQFHFDLPYLSIFNHMA 646
E+ + K+ +K K L T E+ + ++ +
Sbjct: 1541 SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEME-MERMRQTH 1599
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSR---KLSPTPPANKLSIETANDNDEKETD 703
+ + VEE +S +LK+M + K +L + A +D+
Sbjct: 1600 SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1659
Query: 704 EADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+ + +E +L +L +A + + ++ L+ + K+++ +L +++ T A +
Sbjct: 1660 DFE-SEKRLRKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAA-V 1716
Query: 762 TARRSLTTNSNKL---AEERVK---VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK 815
AR+++ L ++ K LE+++ ++++ E + E +++ KK K
Sbjct: 1717 KARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHK 1776
Query: 816 TLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKN 873
+ S D + Q DL+ QL+ +E L+ K Q+L++ E L+ +K L +
Sbjct: 1777 AAVAQASRDLA--QINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQE 1834
Query: 874 AKSLRSDKALDL---NTKKTTQLENELKEALAKI---KELEMICQDEKSEKKVRFTEATK 927
AK + L+ K+ L + LKE + K+ ++ + ++ + E+ R +
Sbjct: 1835 AKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLR 1894
Query: 928 KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL 987
+ + +A +SL+ D + +FK RI + ++
Sbjct: 1895 DTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFK-RIGDLQAAIEDEM 1953
Query: 988 QLKKMVEDLECEIGEM---YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKN 1037
+ + EDL + +M Y KN L G + ++LE +D ++S LSKN
Sbjct: 1954 ESDEN-EDLINSLQDMVTKYQKRKNK-LEG-DSDVDSELEDRVDGVKSWLSKN 2003
Score = 65.7 bits (153), Expect = 2e-09
Identities = 123/613 (20%), Positives = 242/613 (39%), Gaps = 55/613 (8%)
Query: 1222 LSIELTSEKD--ELQARFIKTES-KFITLEAEMRDLKADYENKITSLE---------STI 1269
L+ ELT E++ E ++ + E+ + + E EM++L+ Y+ +E I
Sbjct: 1307 LTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLI 1366
Query: 1270 AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE 1329
A +++ + +D KY+ A V+ + R Q++ + +L
Sbjct: 1367 RAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNK-RQLERRLG 1425
Query: 1330 KTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERK 1389
+A+S ++ + QLK +L + E K + D++L +
Sbjct: 1426 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHE 1485
Query: 1390 KLDRMRIAHDKDVKNKD---AELATLKGKLKILEQNSGAGAKRITELKQEYEE---TVKK 1443
+ R ++ +K + KD AE +LK +L+ + + +++ L+ E ++ K
Sbjct: 1486 EAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1545
Query: 1444 LEHSLALEKAEYEELTGKYELLEEE--------HVVTKARLTVEKEQAQGELLHVQKELS 1495
E SLA K + +L K + EEE ++ +A+L +E E + H KE+
Sbjct: 1546 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTH-SKEME 1604
Query: 1496 TALGEI----KTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
+ E+ ++ Q+KL E + Q + ++R G ++N R +
Sbjct: 1605 SRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR--EKRELEGKLATLSDQVNRRDFE 1662
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E+ LR R L + ++
Sbjct: 1663 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAM 1722
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERD----NYKQMLEA 1667
IE + +I KT E Q++ ++ E + N++ + + + +K +
Sbjct: 1723 EVEIEDLH-LQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1781
Query: 1668 AQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLA----- 1722
A + +A+I D A++ ++ +++E + K+ L+ QV LE + + L++
Sbjct: 1782 ASRDLAQI--NDLQAQLEE---ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAK 1836
Query: 1723 -SKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQ 1781
+L T L E++ + RL + SRL E E+L R+A A E +K Q
Sbjct: 1837 IRELETRLEFERTQVK-RLESLASRLKE-NMEKLTEERDQRIA--AENREKEQNKRLQRQ 1892
Query: 1782 QR-LLQETSTLAR 1793
R +E LAR
Sbjct: 1893 LRDTKEEMGELAR 1905
Score = 59.7 bits (138), Expect = 1e-07
Identities = 97/501 (19%), Positives = 207/501 (41%), Gaps = 34/501 (6%)
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETA 694
DL S + A L+K R+ + + L L+ + R+ +L + E +
Sbjct: 1426 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLE--GQQVRNHELEKKQ--RRFDSELS 1481
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
++E + ++ +++ ++ EA L++++EE + D ++V L +++ ++
Sbjct: 1482 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDIS- 1540
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
S S A + + E +VK E+E+DE + E+ RL E+ ++
Sbjct: 1541 -SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTH 1599
Query: 815 KTLIKSRSLDASD-QQNVDLK-RQLQV-----IEQEASVLRAK--------TQSLEADNE 859
++SR + + +Q+ K +Q++V E + VLR K T S + +
Sbjct: 1600 SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1659
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLN-TKKTTQLENELKEALAKIKELEMICQDEKSEK 918
++E + + LK K+L +D L L+ K + + E+ + +++E E C +
Sbjct: 1660 DFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1719
Query: 919 K---VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
K V + + D K+K + + + ++ K K
Sbjct: 1720 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDM-NELMKKHKAA 1778
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMY----VVMKNAGLSGKEMTAKTKLEKEIDEIR 1031
+ + DL L+ +E+ E E+ + + M K+ + ++ +IR
Sbjct: 1779 VAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIR 1838
Query: 1032 SKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLT 1091
++ + E T K RL++ ++LK+ KL ++D + +N L Q +
Sbjct: 1839 ELETRLEFERTQVK-RLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1897
Query: 1092 EEM---KNREAQINKLSADLK 1109
EEM +EA+ ++ +L+
Sbjct: 1898 EEMGELARKEAEASRKKHELE 1918
Score = 54.0 bits (124), Expect = 5e-06
Identities = 143/761 (18%), Positives = 305/761 (40%), Gaps = 49/761 (6%)
Query: 357 RPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADE 416
RP E Q + EQ+R K + ++L + E +KE +L ++ E E
Sbjct: 1257 RPLIEVQLSE-EQIRNK----DEEIQQLRSKLEKAEKERNELRLNSDRLESRISE-LTSE 1310
Query: 417 YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
+ R E + + + + E++ +L Q + + KK +E++ R R
Sbjct: 1311 LTDERNTGESASQLLDAETAERLRAEKEMKEL-QTQYDALKKQMEVMEMEVMEARLIRAA 1369
Query: 477 ELEQEVARSTEVA-LRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTR--GGSQE 533
E+ EV RL+ E A FT + E + ++ L R G Q
Sbjct: 1370 EINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQA 1429
Query: 534 DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE 593
D + R LQ ++ L +L++ + +QV KQ D+ ++ HE E
Sbjct: 1430 DSEESQRALQQLKKKCQRLTAELQDTKLHLEG-QQVRNHELEKKQRRFDSELS-QAHE-E 1486
Query: 594 TVTNSIQNKMIHA------ASTPSSKEKSDSPPLSIDKTTEET-QFHFDLPYLSIFNHMA 646
+Q + + A S K++ + + I T++ +L +S
Sbjct: 1487 AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD 1546
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEA 705
+L K ++ + + Q +++ +A + + L ++ +E KE +
Sbjct: 1547 EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1606
Query: 706 DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS----VTKTSAGSNT 761
D E++ + +++ + ++EE +DK+ + ++ +EL K+++ V + S
Sbjct: 1607 DE-EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1665
Query: 762 TARRSLTTNSNKLAEERVKV--------LEDEIDEVRKKLIEKERDCERLHAELSLAQKK 813
R+ L LA+ ++ + + EI +++ +L E E C A A+K
Sbjct: 1666 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTC----AAAVKARKA 1721
Query: 814 PKTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL 871
+ I+ L D + L+ QL +++E + ++ + + + D +L ++K +
Sbjct: 1722 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAA-VA 1780
Query: 872 KNAKSLRSDKALDLNTKKTTQLENELKEALAKIK-ELEMICQDEKSEKKVRFTEATKKET 930
+ ++ L L ++ + + EL+E L ++ ++E + Q + V EA +E
Sbjct: 1781 QASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIREL 1840
Query: 931 DT---LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL 987
+T + Q + + ++ +K R+ ++ D ++
Sbjct: 1841 ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEM 1900
Query: 988 -QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE-KEIDEIRSKLSKNDSEFTNEK 1045
+L + + + E+ + +++ + + + A KL K I ++++ + NE
Sbjct: 1901 GELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENED 1960
Query: 1046 --NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
N LQ + K + KLEGD DV + ++ S LS
Sbjct: 1961 LINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLS 2001
Score = 53.2 bits (122), Expect = 9e-06
Identities = 43/225 (19%), Positives = 106/225 (47%), Gaps = 11/225 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ +++ QI+ + + L ++ R+++EK++I R + + N+ + V +
Sbjct: 1722 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1781
Query: 322 LQQ---KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ ++N+L E+ EK+ L +K++ ++S++E + + + AK+ E
Sbjct: 1782 ASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELE 1841
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
T L E +K+ L L + E++ ++ RE EQ + L +L
Sbjct: 1842 T---RLEFERTQVKR-LESLASRLKENMEKLTEERDQRIAAENREKEQN----KRLQRQL 1893
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVA 483
+ T+ + +L +++AE +K E+ + ++ N+ + + ++A
Sbjct: 1894 RDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLA 1938
Score = 48.4 bits (110), Expect = 3e-04
Identities = 57/290 (19%), Positives = 126/290 (43%), Gaps = 14/290 (4%)
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ- 892
+ Q++ ++E LR+K + E + +L+ + +L+ L S+ + NT ++
Sbjct: 1266 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLE--SRISELTSELTDERNTGESASQ 1323
Query: 893 -LENELKEALAKIKEL-EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXX 950
L+ E E L KE+ E+ Q + +K++ E E +++ +
Sbjct: 1324 LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGE 1383
Query: 951 XXXXXXXQAT-LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ K Q+ F+ ++ + K QL++ + DL+ + E ++
Sbjct: 1384 WRLKYERAVREVDFTKKRLQQEFEDKLE---VEQQNKRQLERRLGDLQADSEESQRALQQ 1440
Query: 1010 AGLSGKEMTAK---TKLEKEIDEIRS-KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
+ +TA+ TKL E ++R+ +L K F +E ++ E + K KL+ +
Sbjct: 1441 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1500
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA-DLKNATSL 1114
KD+ + +L+ + T+++ + EA++ +S+ + K+ SL
Sbjct: 1501 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASL 1550
Score = 47.6 bits (108), Expect = 5e-04
Identities = 114/588 (19%), Positives = 224/588 (38%), Gaps = 60/588 (10%)
Query: 115 DLGADGSDSNAVTVNLKLPKRRLTGPLPDLDTGQTTNGSQTQLAITKNDSLAERVRKMQL 174
DL AD +S LK +RLT L D TK ++VR +L
Sbjct: 1426 DLQADSEESQRALQQLKKKCQRLTAELQD----------------TKLHLEGQQVRNHEL 1469
Query: 175 LKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNL 234
K Q F+ E S E +R + + EK R KD + + ++ K+ +
Sbjct: 1470 EKKQRRFDSELSQAHEEAQR---EKLQREKLQREKDMLLAEAFSLKQQLEEKDM-DIAGF 1525
Query: 235 KPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEK 294
V V +++ + +++ ++E+D + +E+ K
Sbjct: 1526 TQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK 1585
Query: 295 SDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL 354
+ + T +K R EV + +Q + E +E+ QK+ + EL
Sbjct: 1586 LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1645
Query: 355 ETRPST---EAQTRQIE---QLRAKLLAAETLCEE---LMDENEDMKKELRDLXXXXXXM 405
E + +T + R E +LR L + L + ++D ++ R++ +
Sbjct: 1646 EGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQL 1705
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT--ERKADQLEQEKAEHEKKLLEIV 463
+++ A + E+E + ++ KT E + +L++EK E + +L E
Sbjct: 1706 EESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQ 1765
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ + +++ K + +R LQ +L EAN + L + Q + + +
Sbjct: 1766 EDMNELMKKH--KAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL-QSQVEFLEQ 1822
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
S + + A+ +R+L+ LE E R Q++ E + K+ N +++ D
Sbjct: 1823 SMVDKSLVSRQEAK-IRELETRLEFE---RTQVKRLESLASRLKE-NMEKLTEER---DQ 1874
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
+ + E E QNK + + +E + + + ++ + DL L N
Sbjct: 1875 RIAAENREKE------QNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAAN 1928
Query: 644 HMAANNLRKTAARV------------EEDNESLLLQLKKMATKARSRK 679
+L+ R+ ++NE L+ L+ M TK + RK
Sbjct: 1929 QSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRK 1976
>BC130453-1|AAI30454.1| 1726|Homo sapiens ANKRD26 protein protein.
Length = 1726
Score = 78.2 bits (184), Expect = 3e-13
Identities = 180/906 (19%), Positives = 370/906 (40%), Gaps = 83/906 (9%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
N + D ++ L Q + + CE K+ +LL ++ + S +LK+Q
Sbjct: 692 NQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKD------SVSLLKIQ 745
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIE-QLRAKLLAAET-LC 381
E ++ + LT KI+++E ++ ++T++I+ QL + + E LC
Sbjct: 746 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELC 805
Query: 382 EELMDEN-EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
N E+ K+ D Q +E+Q + ++++LE +++ L +L+
Sbjct: 806 SLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT---LEMELRT 862
Query: 441 TERKADQLEQEKAEHEKKLLEIVGG---PDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ +Q+ QE+ + +++L DG+ + K+ E E+A+ + + +
Sbjct: 863 VKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKK---MNSENSHS 919
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLT--RGGSQEDPAQLLRDLQDSLEREADLREQ 555
K S+++ E + + R + + +QE + DL+ E+ DL++
Sbjct: 920 HEEEKDLSHKNSMLQ----EEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKT 975
Query: 556 LRNAEEE-TANCKQVNP--PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ EE T Q N + M ++ + + E + +++ A+
Sbjct: 976 IKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD 1035
Query: 613 KEKSDSPP----LSIDKTTEET-----QFHFDLPYLSIFNHMAANNLRKTAARVEEDNES 663
+++S++ L+ + +E + +FD+ L N + + L KT +++ S
Sbjct: 1036 RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLN----S 1091
Query: 664 LLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATV 723
L ++ R + L LS +T E E + ++K+ + +QE+
Sbjct: 1092 LEIEFHHTRDALREKTLGLERVQKDLS-QTQCQMKEME-QKYQNEQVKVNKYIGKQES-- 1147
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR---RSLTTNSNK---LAEE 777
+ ++ +L+ + L++Q+ + +K + KT + L S K L EE
Sbjct: 1148 VEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEE 1207
Query: 778 RVKVLEDEIDEVRKKLIEKERD-CERLHAELSLAQKKPKTLIKSR----SLDASDQQNVD 832
R K L E + ++++ + E + ER L Q+ TL K SL+ + + ++
Sbjct: 1208 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1267
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADN-------EKLQTENKKLQL----LKNAKSLRSDK 881
L+ + Q ++++ +R + Q + + EK+Q +KL+ LK + DK
Sbjct: 1268 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDK 1327
Query: 882 ALDLNTKK-TTQLENELKEALAKIKELEMICQ---DEKSEKKVRFTEATKKETDTLKSKQ 937
+L L + KE L K+ EL+ + D++ +K V + LK +
Sbjct: 1328 IEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTR 1387
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE 997
Q + + + + T + L L + L+
Sbjct: 1388 KKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1447
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK-------NRLQT 1050
E+ M V K K K KLE+E+ +RS + +N E K R +
Sbjct: 1448 EELLSMKTVQKKCEKLQKN---KKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQ 1504
Query: 1051 EIA-KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
EIA KLK+VN L+ N + EN +++ +Q + +++++ ++I K S +
Sbjct: 1505 EIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKI-KTSQEDF 1563
Query: 1110 NATSLQ 1115
N T L+
Sbjct: 1564 NKTELE 1569
Score = 64.9 bits (151), Expect = 3e-09
Identities = 154/732 (21%), Positives = 291/732 (39%), Gaps = 64/732 (8%)
Query: 415 DEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENR 474
D S R LE +C +L+ K+KK E K + L++E +E + EI Q E++
Sbjct: 746 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETK----EIKS-----QLEHQ 796
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
E E+E+ L+ L + K ++ K+ + ++ R E
Sbjct: 797 KVEWERELCS-------LRFSLNQEEEKRRNADTLYEKIRE----QLRRKEEQYRKEVEV 845
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET 594
QL LQ +LE E + N + N Q + +++ D I+T + + +
Sbjct: 846 KQQLELSLQ-TLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKE 904
Query: 595 VTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTA 654
+ + K +++ ++ S +E+ D + E ++ + N +
Sbjct: 905 I--EMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDL 962
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL 714
V+E NE L +K+ + L+ E A N + E ++ ++ +
Sbjct: 963 KIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEV 1022
Query: 715 ELNEQEATVLRRKVEELEQDKEALK---KQVKELTSKISSVTKTSAGSNTTARRSLTTNS 771
E ++ E K L+ ++ ++ S++ SN + +
Sbjct: 1023 ESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDV-SNLKDNNEILSQQ 1081
Query: 772 NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
E ++ LE E R L EK ER+ +LS Q + K + + + + + N
Sbjct: 1082 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEM-EQKYQNEQVKVNK 1140
Query: 832 DLKRQLQVIEQEASVLRAKTQSL--EADNEKLQTENKKLQLLKNAKSLRS--DKALDLNT 887
+ +Q + +E+ S L+++ L + D+ + +NK+ ++ + K +
Sbjct: 1141 YIGKQ-ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESE 1199
Query: 888 KKTTQLENELKEALAK---IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K++ LE KE +++ +KE + ++EK+E++V + ++ DTLK +
Sbjct: 1200 KQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1259
Query: 945 XXXXXXXXXXXXXQATLKSL------KDDAQKSFKP--RIPKKPTDLTTKLQ-----LKK 991
Q K L +AQ R +K D KL+ LK
Sbjct: 1260 VTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV 1319
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
V+ +I E+ + NA LS E K +L K++ E++ L N + + L+ E
Sbjct: 1320 TVKKQMDKIEELQKNLLNANLSEDE---KEQL-KKLMELKQSLECNLDQEMKKNVELERE 1375
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
I K++ K+ K N+Y EN + KT EM + QINKL + +
Sbjct: 1376 ITGFKNL-LKMTRKK---LNEY---ENGEFSFHGDLKTSQFEM---DIQINKLKHKIDDL 1425
Query: 1112 TS-LQTTMSDCM 1122
T+ L+T S C+
Sbjct: 1426 TAELETAGSKCL 1437
Score = 55.6 bits (128), Expect = 2e-06
Identities = 101/508 (19%), Positives = 199/508 (39%), Gaps = 50/508 (9%)
Query: 1259 ENKITSLESTIAAKDVHIKQLE-DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXX-- 1315
E K S ++++ +++ + +LE D ++ +K + +++V+ +
Sbjct: 922 EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEE 981
Query: 1316 XXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++ +L AE++ ++ K +LE E
Sbjct: 982 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 1041
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+EL+ Q R + R++ + DV N LK +IL Q ++ L+
Sbjct: 1042 SKRELELAFQRARDECSRLQDKMNFDVSN-------LKDNNEILSQQLFKTESKLNSLEI 1094
Query: 1436 EYEETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
E+ T L E +L LE+ + + + ++ E E ++ V K + E V++ L
Sbjct: 1095 EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQE--SVEERL 1152
Query: 1495 STALGEIKTLQEKLG-TESAAWNTEKT--EMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
S E L+++L + A N EKT +Q+ ++ ++L + E + + L++
Sbjct: 1153 SQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKL-----QAESEKQSLLLEE 1207
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
R +EL + + ++ ++ ER + R
Sbjct: 1208 RNKELISECNHLKERQYQYENEKA------------ER-EVVVRQLQQELADTLKKQSMS 1254
Query: 1612 XXXIEQSEKAR---KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEA- 1667
+E + + R + E D K + GQ+ E + H + R + ++KQ LE
Sbjct: 1255 EASLEVTSRYRINLEDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKD 1313
Query: 1668 -AQKSMAEIKNGDKSARIHRNSIS---STDEEEYRNKVALLEQQVACLEDELCESRLLAS 1723
A+ + K DK + +N ++ S DE+E K+ L+Q + C D+
Sbjct: 1314 NAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ-------EM 1366
Query: 1724 KLNTELVSEKSSAEVRLAEMQSRLNEYE 1751
K N EL E + + L + +LNEYE
Sbjct: 1367 KKNVELEREITGFKNLLKMTRKKLNEYE 1394
Score = 43.2 bits (97), Expect = 0.010
Identities = 45/194 (23%), Positives = 85/194 (43%), Gaps = 15/194 (7%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+D + + + +I+ L E++ +C ++ K+ IL L ++ T K K
Sbjct: 1411 MDIQINKLKHKIDDLTAELETAGSKCLHLDT-KNQILQEELLSMKTVQKKCEKLQKNKKK 1469
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L+Q+V L +H E E + Q +EIE R + +++ A++
Sbjct: 1470 LEQEVINLRSHIERNMVELGQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAASQENL 1527
Query: 382 EELMDEN-----EDMKKELRDLXXXXXXM---QDNFREDQADEYSSLRRELEQTIKNCRV 433
E+ + N M+ ++DL + Q++F + + ++Y L E +K +
Sbjct: 1528 EQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLE---ELKVRKS 1584
Query: 434 LSFKLKKT-ERKAD 446
LS KL KT ER A+
Sbjct: 1585 LSSKLTKTNERLAE 1598
Score = 38.3 bits (85), Expect = 0.28
Identities = 45/205 (21%), Positives = 92/205 (44%), Gaps = 19/205 (9%)
Query: 303 ANIDTANKYTTGRSSEVLKLQQKVNELTTHN---EDLRDEKKHLTQKIREIESELETRPS 359
A ++TA ++ LQ+++ + T E L+ KK L Q++ + S +E
Sbjct: 1427 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMV 1486
Query: 360 TEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSS 419
Q +Q +Q + A + + E+L KE+ Q+N + + + ++S
Sbjct: 1487 ELGQVKQYKQ-EIEERARQEIAEKL--------KEVNLFLQAQAASQENLEQFRENNFAS 1537
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELE 479
++ ++E IK+ K+K ++ ++ E EK +++ LE + R++ +L
Sbjct: 1538 MKSQMELRIKDLESELSKIKTSQEDFNKTELEK--YKQLYLE-----ELKVRKSLSSKLT 1590
Query: 480 QEVARSTEVALRLQRELAEANSKFT 504
+ R EV +L E ++ S FT
Sbjct: 1591 KTNERLAEVNTKLLVEKQQSRSLFT 1615
Score = 35.5 bits (78), Expect = 2.0
Identities = 35/195 (17%), Positives = 81/195 (41%), Gaps = 5/195 (2%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
++ KL+ K+++LT E + HL K + ++ EL + + + + ++++ + KL
Sbjct: 1414 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKL--- 1470
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE-QTIKNCRVLSF 436
E L E EL + +++ R++ A++ + L+ Q + F
Sbjct: 1471 EQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQF 1530
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+ Q+E + E +L +I + + +++ +Q +V L +L
Sbjct: 1531 RENNFASMKSQMELRIKDLESELSKIKTSQEDFNK-TELEKYKQLYLEELKVRKSLSSKL 1589
Query: 497 AEANSKFTGSNPSLM 511
+ N + N L+
Sbjct: 1590 TKTNERLAEVNTKLL 1604
Score = 34.7 bits (76), Expect = 3.4
Identities = 45/275 (16%), Positives = 108/275 (39%), Gaps = 15/275 (5%)
Query: 1233 LQARFIKTESKFITLEAEM---RDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
L + K E K L+ E+ +++K+ E++ E + + + Q E+ R+ +
Sbjct: 765 LTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQ-EEEKRRNADT 823
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
Y++ + E + L +++L ++ + E + L
Sbjct: 824 LYEKIREQLRRKEEQYRKEVEVKQQLELS--LQTLEMELRTVKSNLNQVVQERNDAQRQL 881
Query: 1350 AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD---LQSERKKLDRMRIAHDKDVKNKD 1406
++ +N E K+++++ E K L +++
Sbjct: 882 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLR 941
Query: 1407 AELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLE 1466
E+ T+K + + E+ K + E ++ ++T+K+ E +L ++Y G+ +L
Sbjct: 942 LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQY---NGRLSVLT 998
Query: 1467 EEHVVTKARLTVE---KEQAQGELLHVQKELSTAL 1498
E+ + ++L E KE+ + E+ L+ A+
Sbjct: 999 AENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI 1033
>AL162272-4|CAC19649.1| 1710|Homo sapiens novel protein protein.
Length = 1710
Score = 78.2 bits (184), Expect = 3e-13
Identities = 180/906 (19%), Positives = 370/906 (40%), Gaps = 83/906 (9%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
N + D ++ L Q + + CE K+ +LL ++ + S +LK+Q
Sbjct: 676 NQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKD------SVSLLKIQ 729
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIE-QLRAKLLAAET-LC 381
E ++ + LT KI+++E ++ ++T++I+ QL + + E LC
Sbjct: 730 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELC 789
Query: 382 EELMDEN-EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
N E+ K+ D Q +E+Q + ++++LE +++ L +L+
Sbjct: 790 SLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT---LEMELRT 846
Query: 441 TERKADQLEQEKAEHEKKLLEIVGG---PDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ +Q+ QE+ + +++L DG+ + K+ E E+A+ + + +
Sbjct: 847 VKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKK---MNSENSHS 903
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLT--RGGSQEDPAQLLRDLQDSLEREADLREQ 555
K S+++ E + + R + + +QE + DL+ E+ DL++
Sbjct: 904 HEEEKDLSHKNSMLQ----EEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKT 959
Query: 556 LRNAEEE-TANCKQVNP--PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ EE T Q N + M ++ + + E + +++ A+
Sbjct: 960 IKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD 1019
Query: 613 KEKSDSPP----LSIDKTTEET-----QFHFDLPYLSIFNHMAANNLRKTAARVEEDNES 663
+++S++ L+ + +E + +FD+ L N + + L KT +++ S
Sbjct: 1020 RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLN----S 1075
Query: 664 LLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATV 723
L ++ R + L LS +T E E + ++K+ + +QE+
Sbjct: 1076 LEIEFHHTRDALREKTLGLERVQKDLS-QTQCQMKEME-QKYQNEQVKVNKYIGKQES-- 1131
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR---RSLTTNSNK---LAEE 777
+ ++ +L+ + L++Q+ + +K + KT + L S K L EE
Sbjct: 1132 VEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEE 1191
Query: 778 RVKVLEDEIDEVRKKLIEKERD-CERLHAELSLAQKKPKTLIKSR----SLDASDQQNVD 832
R K L E + ++++ + E + ER L Q+ TL K SL+ + + ++
Sbjct: 1192 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1251
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADN-------EKLQTENKKLQL----LKNAKSLRSDK 881
L+ + Q ++++ +R + Q + + EK+Q +KL+ LK + DK
Sbjct: 1252 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDK 1311
Query: 882 ALDLNTKK-TTQLENELKEALAKIKELEMICQ---DEKSEKKVRFTEATKKETDTLKSKQ 937
+L L + KE L K+ EL+ + D++ +K V + LK +
Sbjct: 1312 IEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTR 1371
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE 997
Q + + + + T + L L + L+
Sbjct: 1372 KKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1431
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK-------NRLQT 1050
E+ M V K K K KLE+E+ +RS + +N E K R +
Sbjct: 1432 EELLSMKTVQKKCEKLQKN---KKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQ 1488
Query: 1051 EIA-KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
EIA KLK+VN L+ N + EN +++ +Q + +++++ ++I K S +
Sbjct: 1489 EIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKI-KTSQEDF 1547
Query: 1110 NATSLQ 1115
N T L+
Sbjct: 1548 NKTELE 1553
Score = 64.9 bits (151), Expect = 3e-09
Identities = 154/732 (21%), Positives = 291/732 (39%), Gaps = 64/732 (8%)
Query: 415 DEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENR 474
D S R LE +C +L+ K+KK E K + L++E +E + EI Q E++
Sbjct: 730 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETK----EIKS-----QLEHQ 780
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
E E+E+ L+ L + K ++ K+ + ++ R E
Sbjct: 781 KVEWERELCS-------LRFSLNQEEEKRRNADTLYEKIRE----QLRRKEEQYRKEVEV 829
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET 594
QL LQ +LE E + N + N Q + +++ D I+T + + +
Sbjct: 830 KQQLELSLQ-TLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKE 888
Query: 595 VTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTA 654
+ + K +++ ++ S +E+ D + E ++ + N +
Sbjct: 889 I--EMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDL 946
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL 714
V+E NE L +K+ + L+ E A N + E ++ ++ +
Sbjct: 947 KIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEV 1006
Query: 715 ELNEQEATVLRRKVEELEQDKEALK---KQVKELTSKISSVTKTSAGSNTTARRSLTTNS 771
E ++ E K L+ ++ ++ S++ SN + +
Sbjct: 1007 ESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDV-SNLKDNNEILSQQ 1065
Query: 772 NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
E ++ LE E R L EK ER+ +LS Q + K + + + + + N
Sbjct: 1066 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEM-EQKYQNEQVKVNK 1124
Query: 832 DLKRQLQVIEQEASVLRAKTQSL--EADNEKLQTENKKLQLLKNAKSLRS--DKALDLNT 887
+ +Q + +E+ S L+++ L + D+ + +NK+ ++ + K +
Sbjct: 1125 YIGKQ-ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESE 1183
Query: 888 KKTTQLENELKEALAK---IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K++ LE KE +++ +KE + ++EK+E++V + ++ DTLK +
Sbjct: 1184 KQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1243
Query: 945 XXXXXXXXXXXXXQATLKSL------KDDAQKSFKP--RIPKKPTDLTTKLQ-----LKK 991
Q K L +AQ R +K D KL+ LK
Sbjct: 1244 VTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV 1303
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
V+ +I E+ + NA LS E K +L K++ E++ L N + + L+ E
Sbjct: 1304 TVKKQMDKIEELQKNLLNANLSEDE---KEQL-KKLMELKQSLECNLDQEMKKNVELERE 1359
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
I K++ K+ K N+Y EN + KT EM + QINKL + +
Sbjct: 1360 ITGFKNL-LKMTRKK---LNEY---ENGEFSFHGDLKTSQFEM---DIQINKLKHKIDDL 1409
Query: 1112 TS-LQTTMSDCM 1122
T+ L+T S C+
Sbjct: 1410 TAELETAGSKCL 1421
Score = 55.6 bits (128), Expect = 2e-06
Identities = 101/508 (19%), Positives = 199/508 (39%), Gaps = 50/508 (9%)
Query: 1259 ENKITSLESTIAAKDVHIKQLE-DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXX-- 1315
E K S ++++ +++ + +LE D ++ +K + +++V+ +
Sbjct: 906 EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEE 965
Query: 1316 XXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++ +L AE++ ++ K +LE E
Sbjct: 966 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 1025
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+EL+ Q R + R++ + DV N LK +IL Q ++ L+
Sbjct: 1026 SKRELELAFQRARDECSRLQDKMNFDVSN-------LKDNNEILSQQLFKTESKLNSLEI 1078
Query: 1436 EYEETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
E+ T L E +L LE+ + + + ++ E E ++ V K + E V++ L
Sbjct: 1079 EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQE--SVEERL 1136
Query: 1495 STALGEIKTLQEKLG-TESAAWNTEKT--EMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
S E L+++L + A N EKT +Q+ ++ ++L + E + + L++
Sbjct: 1137 SQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKL-----QAESEKQSLLLEE 1191
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
R +EL + + ++ ++ ER + R
Sbjct: 1192 RNKELISECNHLKERQYQYENEKA------------ER-EVVVRQLQQELADTLKKQSMS 1238
Query: 1612 XXXIEQSEKAR---KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEA- 1667
+E + + R + E D K + GQ+ E + H + R + ++KQ LE
Sbjct: 1239 EASLEVTSRYRINLEDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKD 1297
Query: 1668 -AQKSMAEIKNGDKSARIHRNSIS---STDEEEYRNKVALLEQQVACLEDELCESRLLAS 1723
A+ + K DK + +N ++ S DE+E K+ L+Q + C D+
Sbjct: 1298 NAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ-------EM 1350
Query: 1724 KLNTELVSEKSSAEVRLAEMQSRLNEYE 1751
K N EL E + + L + +LNEYE
Sbjct: 1351 KKNVELEREITGFKNLLKMTRKKLNEYE 1378
Score = 43.2 bits (97), Expect = 0.010
Identities = 45/194 (23%), Positives = 85/194 (43%), Gaps = 15/194 (7%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+D + + + +I+ L E++ +C ++ K+ IL L ++ T K K
Sbjct: 1395 MDIQINKLKHKIDDLTAELETAGSKCLHLDT-KNQILQEELLSMKTVQKKCEKLQKNKKK 1453
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L+Q+V L +H E E + Q +EIE R + +++ A++
Sbjct: 1454 LEQEVINLRSHIERNMVELGQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAASQENL 1511
Query: 382 EELMDEN-----EDMKKELRDLXXXXXXM---QDNFREDQADEYSSLRRELEQTIKNCRV 433
E+ + N M+ ++DL + Q++F + + ++Y L E +K +
Sbjct: 1512 EQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLE---ELKVRKS 1568
Query: 434 LSFKLKKT-ERKAD 446
LS KL KT ER A+
Sbjct: 1569 LSSKLTKTNERLAE 1582
Score = 38.3 bits (85), Expect = 0.28
Identities = 45/205 (21%), Positives = 92/205 (44%), Gaps = 19/205 (9%)
Query: 303 ANIDTANKYTTGRSSEVLKLQQKVNELTTHN---EDLRDEKKHLTQKIREIESELETRPS 359
A ++TA ++ LQ+++ + T E L+ KK L Q++ + S +E
Sbjct: 1411 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMV 1470
Query: 360 TEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSS 419
Q +Q +Q + A + + E+L KE+ Q+N + + + ++S
Sbjct: 1471 ELGQVKQYKQ-EIEERARQEIAEKL--------KEVNLFLQAQAASQENLEQFRENNFAS 1521
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELE 479
++ ++E IK+ K+K ++ ++ E EK +++ LE + R++ +L
Sbjct: 1522 MKSQMELRIKDLESELSKIKTSQEDFNKTELEK--YKQLYLE-----ELKVRKSLSSKLT 1574
Query: 480 QEVARSTEVALRLQRELAEANSKFT 504
+ R EV +L E ++ S FT
Sbjct: 1575 KTNERLAEVNTKLLVEKQQSRSLFT 1599
Score = 35.5 bits (78), Expect = 2.0
Identities = 35/195 (17%), Positives = 81/195 (41%), Gaps = 5/195 (2%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
++ KL+ K+++LT E + HL K + ++ EL + + + + ++++ + KL
Sbjct: 1398 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKL--- 1454
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE-QTIKNCRVLSF 436
E L E EL + +++ R++ A++ + L+ Q + F
Sbjct: 1455 EQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQF 1514
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+ Q+E + E +L +I + + +++ +Q +V L +L
Sbjct: 1515 RENNFASMKSQMELRIKDLESELSKIKTSQEDFNK-TELEKYKQLYLEELKVRKSLSSKL 1573
Query: 497 AEANSKFTGSNPSLM 511
+ N + N L+
Sbjct: 1574 TKTNERLAEVNTKLL 1588
Score = 34.7 bits (76), Expect = 3.4
Identities = 45/275 (16%), Positives = 108/275 (39%), Gaps = 15/275 (5%)
Query: 1233 LQARFIKTESKFITLEAEM---RDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
L + K E K L+ E+ +++K+ E++ E + + + Q E+ R+ +
Sbjct: 749 LTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQ-EEEKRRNADT 807
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
Y++ + E + L +++L ++ + E + L
Sbjct: 808 LYEKIREQLRRKEEQYRKEVEVKQQLELS--LQTLEMELRTVKSNLNQVVQERNDAQRQL 865
Query: 1350 AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD---LQSERKKLDRMRIAHDKDVKNKD 1406
++ +N E K+++++ E K L +++
Sbjct: 866 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLR 925
Query: 1407 AELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLE 1466
E+ T+K + + E+ K + E ++ ++T+K+ E +L ++Y G+ +L
Sbjct: 926 LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQY---NGRLSVLT 982
Query: 1467 EEHVVTKARLTVE---KEQAQGELLHVQKELSTAL 1498
E+ + ++L E KE+ + E+ L+ A+
Sbjct: 983 AENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI 1017
>AB177858-1|BAD66836.1| 2046|Homo sapiens KIAA0216 splice variant 1
protein.
Length = 2046
Score = 78.2 bits (184), Expect = 3e-13
Identities = 148/773 (19%), Positives = 316/773 (40%), Gaps = 59/773 (7%)
Query: 299 LRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETR 357
+R L + + + + E+ +L+ K+ + +LR L +I E+ SEL + R
Sbjct: 1235 VRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 1294
Query: 358 PSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDL------XXXXXXMQDNFRE 411
+ E+ ++ ++ A+ L AE +EL + + +KK++ + + N
Sbjct: 1295 NTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEV 1354
Query: 412 DQADEYSSLRRELEQTIKNCRVLSFKLKKT-ERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
D D R + E+ ++ +L++ E K + +Q K + E++L ++ D +
Sbjct: 1355 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQA--DSEE 1412
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGG 530
+ +++L+++ RL EL + G +V E K R +
Sbjct: 1413 SQRALQQLKKK-------CQRLTAELQDTKLHLEG-----QQVRNHELEKKQRRFDSELS 1460
Query: 531 SQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
+ AQ + ++ L+RE D+ + ++ K ++ F K V + + DI
Sbjct: 1461 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ-DIS 1519
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTT----EETQFHFDLPYLSIFNHMA 646
E+ + K+ +K K L T E+ + ++ +
Sbjct: 1520 SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEME-MERMRQTH 1578
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSR---KLSPTPPANKLSIETANDNDEKETD 703
+ + VEE +S +LK+M + K +L + A +D+
Sbjct: 1579 SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1638
Query: 704 EADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+ + +E +L +L +A + + ++ L+ + K+++ +L +++ T A +
Sbjct: 1639 DFE-SEKRLRKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAA-V 1695
Query: 762 TARRSLTTNSNKL---AEERVK---VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK 815
AR+++ L ++ K LE+++ ++++ E + E +++ KK K
Sbjct: 1696 KARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHK 1755
Query: 816 TLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKN 873
+ S D + Q DL+ QL+ +E L+ K Q+L++ E L+ +K L +
Sbjct: 1756 AAVAQASRDLA--QINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQE 1813
Query: 874 AKSLRSDKALDL---NTKKTTQLENELKEALAKI---KELEMICQDEKSEKKVRFTEATK 927
AK + L+ K+ L + LKE + K+ ++ + ++ + E+ R +
Sbjct: 1814 AKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLR 1873
Query: 928 KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL 987
+ + +A +SL+ D + +FK RI + ++
Sbjct: 1874 DTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFK-RIGDLQAAIEDEM 1932
Query: 988 QLKKMVEDLECEIGEM---YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKN 1037
+ + EDL + +M Y KN L G + ++LE +D ++S LSKN
Sbjct: 1933 ESDEN-EDLINSLQDMVTKYQKRKNK-LEG-DSDVDSELEDRVDGVKSWLSKN 1982
Score = 65.7 bits (153), Expect = 2e-09
Identities = 123/613 (20%), Positives = 242/613 (39%), Gaps = 55/613 (8%)
Query: 1222 LSIELTSEKD--ELQARFIKTES-KFITLEAEMRDLKADYENKITSLE---------STI 1269
L+ ELT E++ E ++ + E+ + + E EM++L+ Y+ +E I
Sbjct: 1286 LTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLI 1345
Query: 1270 AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE 1329
A +++ + +D KY+ A V+ + R Q++ + +L
Sbjct: 1346 RAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNK-RQLERRLG 1404
Query: 1330 KTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERK 1389
+A+S ++ + QLK +L + E K + D++L +
Sbjct: 1405 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHE 1464
Query: 1390 KLDRMRIAHDKDVKNKD---AELATLKGKLKILEQNSGAGAKRITELKQEYEE---TVKK 1443
+ R ++ +K + KD AE +LK +L+ + + +++ L+ E ++ K
Sbjct: 1465 EAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1524
Query: 1444 LEHSLALEKAEYEELTGKYELLEEE--------HVVTKARLTVEKEQAQGELLHVQKELS 1495
E SLA K + +L K + EEE ++ +A+L +E E + H KE+
Sbjct: 1525 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTH-SKEME 1583
Query: 1496 TALGEI----KTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
+ E+ ++ Q+KL E + Q + ++R G ++N R +
Sbjct: 1584 SRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR--EKRELEGKLATLSDQVNRRDFE 1641
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E+ LR R L + ++
Sbjct: 1642 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAM 1701
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERD----NYKQMLEA 1667
IE + +I KT E Q++ ++ E + N++ + + + +K +
Sbjct: 1702 EVEIEDLH-LQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1760
Query: 1668 AQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLA----- 1722
A + +A+I D A++ ++ +++E + K+ L+ QV LE + + L++
Sbjct: 1761 ASRDLAQI--NDLQAQLEE---ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAK 1815
Query: 1723 -SKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQ 1781
+L T L E++ + RL + SRL E E+L R+A A E +K Q
Sbjct: 1816 IRELETRLEFERTQVK-RLESLASRLKE-NMEKLTEERDQRIA--AENREKEQNKRLQRQ 1871
Query: 1782 QR-LLQETSTLAR 1793
R +E LAR
Sbjct: 1872 LRDTKEEMGELAR 1884
Score = 59.7 bits (138), Expect = 1e-07
Identities = 97/501 (19%), Positives = 207/501 (41%), Gaps = 34/501 (6%)
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETA 694
DL S + A L+K R+ + + L L+ + R+ +L + E +
Sbjct: 1405 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLE--GQQVRNHELEKKQ--RRFDSELS 1460
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
++E + ++ +++ ++ EA L++++EE + D ++V L +++ ++
Sbjct: 1461 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDIS- 1519
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
S S A + + E +VK E+E+DE + E+ RL E+ ++
Sbjct: 1520 -SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTH 1578
Query: 815 KTLIKSRSLDASD-QQNVDLK-RQLQV-----IEQEASVLRAK--------TQSLEADNE 859
++SR + + +Q+ K +Q++V E + VLR K T S + +
Sbjct: 1579 SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1638
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLN-TKKTTQLENELKEALAKIKELEMICQDEKSEK 918
++E + + LK K+L +D L L+ K + + E+ + +++E E C +
Sbjct: 1639 DFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1698
Query: 919 K---VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
K V + + D K+K + + + ++ K K
Sbjct: 1699 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDM-NELMKKHKAA 1757
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMY----VVMKNAGLSGKEMTAKTKLEKEIDEIR 1031
+ + DL L+ +E+ E E+ + + M K+ + ++ +IR
Sbjct: 1758 VAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIR 1817
Query: 1032 SKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLT 1091
++ + E T K RL++ ++LK+ KL ++D + +N L Q +
Sbjct: 1818 ELETRLEFERTQVK-RLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1876
Query: 1092 EEM---KNREAQINKLSADLK 1109
EEM +EA+ ++ +L+
Sbjct: 1877 EEMGELARKEAEASRKKHELE 1897
Score = 54.0 bits (124), Expect = 5e-06
Identities = 143/761 (18%), Positives = 305/761 (40%), Gaps = 49/761 (6%)
Query: 357 RPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADE 416
RP E Q + EQ+R K + ++L + E +KE +L ++ E E
Sbjct: 1236 RPLIEVQLSE-EQIRNK----DEEIQQLRSKLEKAEKERNELRLNSDRLESRISE-LTSE 1289
Query: 417 YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
+ R E + + + + E++ +L Q + + KK +E++ R R
Sbjct: 1290 LTDERNTGESASQLLDAETAERLRAEKEMKEL-QTQYDALKKQMEVMEMEVMEARLIRAA 1348
Query: 477 ELEQEVARSTEVA-LRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTR--GGSQE 533
E+ EV RL+ E A FT + E + ++ L R G Q
Sbjct: 1349 EINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQA 1408
Query: 534 DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE 593
D + R LQ ++ L +L++ + +QV KQ D+ ++ HE E
Sbjct: 1409 DSEESQRALQQLKKKCQRLTAELQDTKLHLEG-QQVRNHELEKKQRRFDSELS-QAHE-E 1465
Query: 594 TVTNSIQNKMIHA------ASTPSSKEKSDSPPLSIDKTTEET-QFHFDLPYLSIFNHMA 646
+Q + + A S K++ + + I T++ +L +S
Sbjct: 1466 AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD 1525
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEA 705
+L K ++ + + Q +++ +A + + L ++ +E KE +
Sbjct: 1526 EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1585
Query: 706 DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS----VTKTSAGSNT 761
D E++ + +++ + ++EE +DK+ + ++ +EL K+++ V + S
Sbjct: 1586 DE-EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1644
Query: 762 TARRSLTTNSNKLAEERVKV--------LEDEIDEVRKKLIEKERDCERLHAELSLAQKK 813
R+ L LA+ ++ + + EI +++ +L E E C A A+K
Sbjct: 1645 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTC----AAAVKARKA 1700
Query: 814 PKTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL 871
+ I+ L D + L+ QL +++E + ++ + + + D +L ++K +
Sbjct: 1701 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAA-VA 1759
Query: 872 KNAKSLRSDKALDLNTKKTTQLENELKEALAKIK-ELEMICQDEKSEKKVRFTEATKKET 930
+ ++ L L ++ + + EL+E L ++ ++E + Q + V EA +E
Sbjct: 1760 QASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIREL 1819
Query: 931 DT---LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL 987
+T + Q + + ++ +K R+ ++ D ++
Sbjct: 1820 ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEM 1879
Query: 988 -QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE-KEIDEIRSKLSKNDSEFTNEK 1045
+L + + + E+ + +++ + + + A KL K I ++++ + NE
Sbjct: 1880 GELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENED 1939
Query: 1046 --NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
N LQ + K + KLEGD DV + ++ S LS
Sbjct: 1940 LINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLS 1980
Score = 53.2 bits (122), Expect = 9e-06
Identities = 43/225 (19%), Positives = 106/225 (47%), Gaps = 11/225 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ +++ QI+ + + L ++ R+++EK++I R + + N+ + V +
Sbjct: 1701 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1760
Query: 322 LQQ---KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ ++N+L E+ EK+ L +K++ ++S++E + + + AK+ E
Sbjct: 1761 ASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELE 1820
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
T L E +K+ L L + E++ ++ RE EQ + L +L
Sbjct: 1821 T---RLEFERTQVKR-LESLASRLKENMEKLTEERDQRIAAENREKEQN----KRLQRQL 1872
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVA 483
+ T+ + +L +++AE +K E+ + ++ N+ + + ++A
Sbjct: 1873 RDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLA 1917
Score = 48.4 bits (110), Expect = 3e-04
Identities = 57/290 (19%), Positives = 126/290 (43%), Gaps = 14/290 (4%)
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ- 892
+ Q++ ++E LR+K + E + +L+ + +L+ L S+ + NT ++
Sbjct: 1245 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLE--SRISELTSELTDERNTGESASQ 1302
Query: 893 -LENELKEALAKIKEL-EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXX 950
L+ E E L KE+ E+ Q + +K++ E E +++ +
Sbjct: 1303 LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGE 1362
Query: 951 XXXXXXXQAT-LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ K Q+ F+ ++ + K QL++ + DL+ + E ++
Sbjct: 1363 WRLKYERAVREVDFTKKRLQQEFEDKLE---VEQQNKRQLERRLGDLQADSEESQRALQQ 1419
Query: 1010 AGLSGKEMTAK---TKLEKEIDEIRS-KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
+ +TA+ TKL E ++R+ +L K F +E ++ E + K KL+ +
Sbjct: 1420 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1479
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA-DLKNATSL 1114
KD+ + +L+ + T+++ + EA++ +S+ + K+ SL
Sbjct: 1480 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASL 1529
Score = 47.6 bits (108), Expect = 5e-04
Identities = 114/588 (19%), Positives = 224/588 (38%), Gaps = 60/588 (10%)
Query: 115 DLGADGSDSNAVTVNLKLPKRRLTGPLPDLDTGQTTNGSQTQLAITKNDSLAERVRKMQL 174
DL AD +S LK +RLT L D TK ++VR +L
Sbjct: 1405 DLQADSEESQRALQQLKKKCQRLTAELQD----------------TKLHLEGQQVRNHEL 1448
Query: 175 LKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNL 234
K Q F+ E S E +R + + EK R KD + + ++ K+ +
Sbjct: 1449 EKKQRRFDSELSQAHEEAQR---EKLQREKLQREKDMLLAEAFSLKQQLEEKDM-DIAGF 1504
Query: 235 KPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEK 294
V V +++ + +++ ++E+D + +E+ K
Sbjct: 1505 TQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK 1564
Query: 295 SDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL 354
+ + T +K R EV + +Q + E +E+ QK+ + EL
Sbjct: 1565 LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1624
Query: 355 ETRPST---EAQTRQIE---QLRAKLLAAETLCEE---LMDENEDMKKELRDLXXXXXXM 405
E + +T + R E +LR L + L + ++D ++ R++ +
Sbjct: 1625 EGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQL 1684
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT--ERKADQLEQEKAEHEKKLLEIV 463
+++ A + E+E + ++ KT E + +L++EK E + +L E
Sbjct: 1685 EESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQ 1744
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ + +++ K + +R LQ +L EAN + L + Q + + +
Sbjct: 1745 EDMNELMKKH--KAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL-QSQVEFLEQ 1801
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
S + + A+ +R+L+ LE E R Q++ E + K+ N +++ D
Sbjct: 1802 SMVDKSLVSRQEAK-IRELETRLEFE---RTQVKRLESLASRLKE-NMEKLTEER---DQ 1853
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
+ + E E QNK + + +E + + + ++ + DL L N
Sbjct: 1854 RIAAENREKE------QNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAAN 1907
Query: 644 HMAANNLRKTAARV------------EEDNESLLLQLKKMATKARSRK 679
+L+ R+ ++NE L+ L+ M TK + RK
Sbjct: 1908 QSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRK 1955
>AB053470-1|BAC54109.1| 1088|Homo sapiens ELKS delta protein.
Length = 1088
Score = 78.2 bits (184), Expect = 3e-13
Identities = 158/779 (20%), Positives = 332/779 (42%), Gaps = 75/779 (9%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL 374
R + ++ LQ ++ E+ N+ LR + + K+ + ++T S E + + LR
Sbjct: 147 RDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA--LRKDE 204
Query: 375 LAAETLCEE----LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL--EQTI 428
+ T+ +E + +EN+ M+ ++ L +D + Q D S E T
Sbjct: 205 ASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE 264
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEV----- 482
+N + L + ER+A +L + E+ L I + R+ IK+L + +
Sbjct: 265 ENFQRLH---AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 321
Query: 483 -ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
A++TE R LAEA SL++ + E + R + D A+ +
Sbjct: 322 SAKATEEDHERTRRLAEAEMHVHHLE-SLLEQKEKENSMLREEMHRRFENAPDSAKT-KA 379
Query: 542 LQDSLERE----ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LQ +E + + + LR+ EEE K L + + + +++ S +
Sbjct: 380 LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA---LSTEEREEEMKQMEVYRSHS--K 434
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
++NK I S++ ++ L T QF ++ + ++ AA +
Sbjct: 435 FMKNK-IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR-AAIL 492
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELN 717
+ + ++L L+L++ T NK + + + +EK T + ++K +L++
Sbjct: 493 QTEVDALRLRLEEKETML-----------NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 541
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE- 776
E++ VL++K+E L++ +KQ+ L ++ S+ + ++T +LTT LAE
Sbjct: 542 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT----ALTTLEEALAEK 597
Query: 777 ----ERVKVLEDEIDEVRKKLIEK-ERDCERLHAELSLAQ----KKPKTLIKSRSLDASD 827
ER+K D + +++ I+ ++D + L ++SL Q +K +L+ + AS
Sbjct: 598 ERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE-HASS 656
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
+ LK+ ++ E ++ + K + L+ +++ + L+ A SD+ L
Sbjct: 657 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE--ARASPEMSDRIQHLE- 713
Query: 888 KKTTQLENELKEALAKIKELEMI---CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
++ T+ ++E +A A++ L I ++EK++K + E ++ D K
Sbjct: 714 REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ 773
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGE-M 1003
+ +L D +Q+ + + KK +E+LE + E +
Sbjct: 774 VEKKKSAQMLEEARRREDNLNDSSQQ-LQDSLRKK----------DDRIEELEEALRESV 822
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
+ + + +E +A+T EK+++E+ + K E + K +L + L + L
Sbjct: 823 QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 881
Score = 55.2 bits (127), Expect = 2e-06
Identities = 95/544 (17%), Positives = 220/544 (40%), Gaps = 39/544 (7%)
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
+NKI ++ ++ KD + L+ L TN ++ ++ +E+ ++ Q
Sbjct: 437 KNKIGQVKQELSRKDTELLALQTKLETLTN-QFSDSKQHIEV--LKESLTAKEQRAAILQ 493
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
E++ +++LE+ E + ++ + + + + K +
Sbjct: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE 553
Query: 1379 ELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYE 1438
L L+ + K++ ++ + VK+ A+ L LE+ + I LK++ +
Sbjct: 554 NLQEQLRDKEKQMSSLK----ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 609
Query: 1439 ETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
++ + + K + ++L K LL+ + +A L KE A K+ S
Sbjct: 610 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS--- 666
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
+KTL+ L + E +M++ + E E ++ R+ ERE+
Sbjct: 667 -RLKTLEIALEQK----KEECLKMESQLKKAHEAALEARASPE---MSDRIQHLEREITR 718
Query: 1559 ANDRRDVLEHHHDXXXXXXXXXXXXXXDYE-RVSKIQRXXXXXXXXXXXXXXXXXXXIEQ 1617
D + D D + ++++++R EQ
Sbjct: 719 YKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK-----EQ 773
Query: 1618 SEKARKAEITDTKTRYEGQMNTMRDELK-SLHNQVSRFRRERDNYKQMLE-AAQKSMAEI 1675
EK + A++ + R E +N +L+ SL + R + ++ ++ A++ M +
Sbjct: 774 VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREM--V 831
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSS 1735
++SAR + + EE + ++Q++ ++ +L ++ ++ T L + ++
Sbjct: 832 LAQEESARTN----AEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 887
Query: 1736 AEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQ--RLLQETSTLAR 1793
L E+ E ++E LL++ + A +A +EL+ K++ +++ L +E L +
Sbjct: 888 RRKHLEEVL----EMKQEALLAAISEKDANIAL-LELSSSKKKTQEEVAALKREKDRLVQ 942
Query: 1794 DLRQ 1797
L+Q
Sbjct: 943 QLKQ 946
Score = 50.4 bits (115), Expect = 6e-05
Identities = 84/421 (19%), Positives = 170/421 (40%), Gaps = 41/421 (9%)
Query: 182 EKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGG 241
EKE +IE+ +E+R + ++ E+ YK + K+ V+ L + + ++ L
Sbjct: 596 EKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLD------ 649
Query: 242 PXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR 301
L + Q + E LK E + + +E S + R
Sbjct: 650 -LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 708
Query: 302 LANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE 361
+ +++ + T E K Q +V+ L +++ +EK +KI E+E +++ +
Sbjct: 709 IQHLE---REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV 765
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
A + EQ+ K A ++++E + L D +QD+ R+ + D L
Sbjct: 766 ANLKHKEQVEKKKSA------QMLEEARRREDNLND---SSQQLQDSLRK-KDDRIEELE 815
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE 481
L ++++ + E Q E + EK++ E++ M E +ELE
Sbjct: 816 EALRESVQ-------ITAEREMVLAQEESARTNAEKQVEELL-----MAMEKVKQELESM 863
Query: 482 VARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
A+ + Q+ LAE + T K + E +++ + +L S++D L +
Sbjct: 864 KAKLSST----QQSLAEKETHLTNLRAERRKHLE-EVLEMKQEALLAAISEKDANIALLE 918
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L S ++ + L+ ++ +Q+ T ++M DN D H + +N +
Sbjct: 919 LSSSKKKTQEEVAALKREKDRLV--QQLKQQTQNRMKLMADNYE--DDHFKSSHSNQTNH 974
Query: 602 K 602
K
Sbjct: 975 K 975
Score = 45.6 bits (103), Expect = 0.002
Identities = 88/550 (16%), Positives = 206/550 (37%), Gaps = 27/550 (4%)
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKD 1273
+L T + + + ++K L AR + L+++ KA E+ + +A +
Sbjct: 283 LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR--LAEAE 340
Query: 1274 VHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+H+ LE L Q K E + E + R Q + K+ E
Sbjct: 341 MHVHHLESLLEQ----KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+ E+ LKS+ A S + +NK ++ +L + +L
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTEL-- 454
Query: 1394 MRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS---LAL 1450
+A ++ + + K +++L+++ A +R L+ E + +LE L
Sbjct: 455 --LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 512
Query: 1451 EKAEYEELTGKYELLEEEHVVTKARLTVEKEQA---QGELLHVQKELSTALGEIKTLQEK 1507
+ + +++ + E K L V++ + Q ++ ++Q++L ++ +L+E+
Sbjct: 513 KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 572
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+ + A + T ++ +L+E L +ER + D+RE++ N ++D+ +
Sbjct: 573 VKSLQA----DTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 628
Query: 1568 HHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEIT 1627
+ ++ E+ K E +
Sbjct: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME-S 687
Query: 1628 DTKTRYEGQMNT-----MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSA 1682
K +E + M D ++ L +++R++ E + ++ + + E++N +K+
Sbjct: 688 QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVEN-EKND 746
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAE 1742
+ + + ++ KVA L+ + + + + A + L + L +
Sbjct: 747 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 806
Query: 1743 MQSRLNEYEE 1752
R+ E EE
Sbjct: 807 KDDRIEELEE 816
Score = 39.1 bits (87), Expect = 0.16
Identities = 79/364 (21%), Positives = 153/364 (42%), Gaps = 30/364 (8%)
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENK---ITSLESTIAAKDVHI 1276
R++++ L + + LQ + E + +L+ ++ L+AD N +T+LE +A K+ I
Sbjct: 543 RKVNV-LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 601
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
++L++ D+ DE E+ + Q +L+ + L + +
Sbjct: 602 ERLKEQ-----RDR-DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASL--LDLKEH 653
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR- 1395
A+ L + LK D ++L+ S + KA E + ++ + DR++
Sbjct: 654 ASSLASSGLKKD-SRLKTLEIALEQKKEECLKMESQLK-KAHEAALEARASPEMSDRIQH 711
Query: 1396 ----IAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLAL 1450
I KD +K AE+ L LK +E K+I EL+++ ++ KK+ + L
Sbjct: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVAN---L 768
Query: 1451 EKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ---KELSTALGEIKTLQEK 1507
+ E E ++LEE + L +Q Q L +EL AL E + +
Sbjct: 769 KHKEQVEKKKSAQMLEEAR-RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE 827
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVE--RARLNA-RLDQRERELRAANDRRD 1564
A + +T + + L + E+E +A+L++ + E+E N R +
Sbjct: 828 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 887
Query: 1565 VLEH 1568
+H
Sbjct: 888 RRKH 891
Score = 35.9 bits (79), Expect = 1.5
Identities = 73/422 (17%), Positives = 155/422 (36%), Gaps = 28/422 (6%)
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKI-----LEQNSGA---GAKRITELK 1434
DLQ++ K++ R KDV+ K+++L++ +K L++ A +IT K
Sbjct: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYEL----LEEEHVVTKARLTVEKEQAQGELLHV 1490
++Y ++ +H +A +EL + +L ++ T E + + LH
Sbjct: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Query: 1491 Q-----KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
+ KEL ++ ++ ++ T+ N ++ + LQ + E
Sbjct: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
Query: 1546 NARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
RL + E + + E + D + +Q
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 1606 XXXXXXXXXIEQSEKARKAEITDTKTRYE--GQMNTMRDELKSLHNQVSRFRRERDNYKQ 1663
E+ + + T+ R E QM R K + N++ + ++E
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
Query: 1664 MLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLAS 1723
L A Q + + N ++ H E + + EQ+ A L+ E+ RL
Sbjct: 453 ELLALQTKLETLTNQFSDSKQH--------IEVLKESLTAKEQRAAILQTEVDALRLRLE 504
Query: 1724 KLNTELVSEKSSAEVRLAEMQSRLNE-YEEERLLSSGRARVAGLATRMELAWHKERDEQQ 1782
+ T L + + E ++ E ++ + +L +V L ++E + RD+++
Sbjct: 505 EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEK 564
Query: 1783 RL 1784
++
Sbjct: 565 QM 566
>AB028997-1|BAA83026.2| 1715|Homo sapiens KIAA1074 protein protein.
Length = 1715
Score = 78.2 bits (184), Expect = 3e-13
Identities = 180/906 (19%), Positives = 370/906 (40%), Gaps = 83/906 (9%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
N + D ++ L Q + + CE K+ +LL ++ + S +LK+Q
Sbjct: 681 NQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKD------SVSLLKIQ 734
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIE-QLRAKLLAAET-LC 381
E ++ + LT KI+++E ++ ++T++I+ QL + + E LC
Sbjct: 735 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELC 794
Query: 382 EELMDEN-EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
N E+ K+ D Q +E+Q + ++++LE +++ L +L+
Sbjct: 795 SLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT---LEMELRT 851
Query: 441 TERKADQLEQEKAEHEKKLLEIVGG---PDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ +Q+ QE+ + +++L DG+ + K+ E E+A+ + + +
Sbjct: 852 VKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKK---MNSENSHS 908
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLT--RGGSQEDPAQLLRDLQDSLEREADLREQ 555
K S+++ E + + R + + +QE + DL+ E+ DL++
Sbjct: 909 HEEEKDLSHKNSMLQ----EEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKT 964
Query: 556 LRNAEEE-TANCKQVNP--PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ EE T Q N + M ++ + + E + +++ A+
Sbjct: 965 IKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD 1024
Query: 613 KEKSDSPP----LSIDKTTEET-----QFHFDLPYLSIFNHMAANNLRKTAARVEEDNES 663
+++S++ L+ + +E + +FD+ L N + + L KT +++ S
Sbjct: 1025 RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLN----S 1080
Query: 664 LLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATV 723
L ++ R + L LS +T E E + ++K+ + +QE+
Sbjct: 1081 LEIEFHHTRDALREKTLGLERVQKDLS-QTQCQMKEME-QKYQNEQVKVNKYIGKQES-- 1136
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR---RSLTTNSNK---LAEE 777
+ ++ +L+ + L++Q+ + +K + KT + L S K L EE
Sbjct: 1137 VEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEE 1196
Query: 778 RVKVLEDEIDEVRKKLIEKERD-CERLHAELSLAQKKPKTLIKSR----SLDASDQQNVD 832
R K L E + ++++ + E + ER L Q+ TL K SL+ + + ++
Sbjct: 1197 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 1256
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADN-------EKLQTENKKLQL----LKNAKSLRSDK 881
L+ + Q ++++ +R + Q + + EK+Q +KL+ LK + DK
Sbjct: 1257 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDK 1316
Query: 882 ALDLNTKK-TTQLENELKEALAKIKELEMICQ---DEKSEKKVRFTEATKKETDTLKSKQ 937
+L L + KE L K+ EL+ + D++ +K V + LK +
Sbjct: 1317 IEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTR 1376
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE 997
Q + + + + T + L L + L+
Sbjct: 1377 KKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1436
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK-------NRLQT 1050
E+ M V K K K KLE+E+ +RS + +N E K R +
Sbjct: 1437 EELLSMKTVQKKCEKLQKN---KKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQ 1493
Query: 1051 EIA-KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
EIA KLK+VN L+ N + EN +++ +Q + +++++ ++I K S +
Sbjct: 1494 EIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKI-KTSQEDF 1552
Query: 1110 NATSLQ 1115
N T L+
Sbjct: 1553 NKTELE 1558
Score = 64.9 bits (151), Expect = 3e-09
Identities = 154/732 (21%), Positives = 291/732 (39%), Gaps = 64/732 (8%)
Query: 415 DEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENR 474
D S R LE +C +L+ K+KK E K + L++E +E + EI Q E++
Sbjct: 735 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETK----EIKS-----QLEHQ 785
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
E E+E+ L+ L + K ++ K+ + ++ R E
Sbjct: 786 KVEWERELCS-------LRFSLNQEEEKRRNADTLYEKIRE----QLRRKEEQYRKEVEV 834
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET 594
QL LQ +LE E + N + N Q + +++ D I+T + + +
Sbjct: 835 KQQLELSLQ-TLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKE 893
Query: 595 VTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTA 654
+ + K +++ ++ S +E+ D + E ++ + N +
Sbjct: 894 I--EMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDL 951
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL 714
V+E NE L +K+ + L+ E A N + E ++ ++ +
Sbjct: 952 KIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEV 1011
Query: 715 ELNEQEATVLRRKVEELEQDKEALK---KQVKELTSKISSVTKTSAGSNTTARRSLTTNS 771
E ++ E K L+ ++ ++ S++ SN + +
Sbjct: 1012 ESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDV-SNLKDNNEILSQQ 1070
Query: 772 NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
E ++ LE E R L EK ER+ +LS Q + K + + + + + N
Sbjct: 1071 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEM-EQKYQNEQVKVNK 1129
Query: 832 DLKRQLQVIEQEASVLRAKTQSL--EADNEKLQTENKKLQLLKNAKSLRS--DKALDLNT 887
+ +Q + +E+ S L+++ L + D+ + +NK+ ++ + K +
Sbjct: 1130 YIGKQ-ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESE 1188
Query: 888 KKTTQLENELKEALAK---IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K++ LE KE +++ +KE + ++EK+E++V + ++ DTLK +
Sbjct: 1189 KQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1248
Query: 945 XXXXXXXXXXXXXQATLKSL------KDDAQKSFKP--RIPKKPTDLTTKLQ-----LKK 991
Q K L +AQ R +K D KL+ LK
Sbjct: 1249 VTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV 1308
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
V+ +I E+ + NA LS E K +L K++ E++ L N + + L+ E
Sbjct: 1309 TVKKQMDKIEELQKNLLNANLSEDE---KEQL-KKLMELKQSLECNLDQEMKKNVELERE 1364
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
I K++ K+ K N+Y EN + KT EM + QINKL + +
Sbjct: 1365 ITGFKNL-LKMTRKK---LNEY---ENGEFSFHGDLKTSQFEM---DIQINKLKHKIDDL 1414
Query: 1112 TS-LQTTMSDCM 1122
T+ L+T S C+
Sbjct: 1415 TAELETAGSKCL 1426
Score = 55.6 bits (128), Expect = 2e-06
Identities = 101/508 (19%), Positives = 199/508 (39%), Gaps = 50/508 (9%)
Query: 1259 ENKITSLESTIAAKDVHIKQLE-DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXX-- 1315
E K S ++++ +++ + +LE D ++ +K + +++V+ +
Sbjct: 911 EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEE 970
Query: 1316 XXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++ +L AE++ ++ K +LE E
Sbjct: 971 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 1030
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+EL+ Q R + R++ + DV N LK +IL Q ++ L+
Sbjct: 1031 SKRELELAFQRARDECSRLQDKMNFDVSN-------LKDNNEILSQQLFKTESKLNSLEI 1083
Query: 1436 EYEETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
E+ T L E +L LE+ + + + ++ E E ++ V K + E V++ L
Sbjct: 1084 EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQE--SVEERL 1141
Query: 1495 STALGEIKTLQEKLG-TESAAWNTEKT--EMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
S E L+++L + A N EKT +Q+ ++ ++L + E + + L++
Sbjct: 1142 SQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKL-----QAESEKQSLLLEE 1196
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
R +EL + + ++ ++ ER + R
Sbjct: 1197 RNKELISECNHLKERQYQYENEKA------------ER-EVVVRQLQQELADTLKKQSMS 1243
Query: 1612 XXXIEQSEKAR---KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEA- 1667
+E + + R + E D K + GQ+ E + H + R + ++KQ LE
Sbjct: 1244 EASLEVTSRYRINLEDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKD 1302
Query: 1668 -AQKSMAEIKNGDKSARIHRNSIS---STDEEEYRNKVALLEQQVACLEDELCESRLLAS 1723
A+ + K DK + +N ++ S DE+E K+ L+Q + C D+
Sbjct: 1303 NAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ-------EM 1355
Query: 1724 KLNTELVSEKSSAEVRLAEMQSRLNEYE 1751
K N EL E + + L + +LNEYE
Sbjct: 1356 KKNVELEREITGFKNLLKMTRKKLNEYE 1383
Score = 43.2 bits (97), Expect = 0.010
Identities = 45/194 (23%), Positives = 85/194 (43%), Gaps = 15/194 (7%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+D + + + +I+ L E++ +C ++ K+ IL L ++ T K K
Sbjct: 1400 MDIQINKLKHKIDDLTAELETAGSKCLHLDT-KNQILQEELLSMKTVQKKCEKLQKNKKK 1458
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L+Q+V L +H E E + Q +EIE R + +++ A++
Sbjct: 1459 LEQEVINLRSHIERNMVELGQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAASQENL 1516
Query: 382 EELMDEN-----EDMKKELRDLXXXXXXM---QDNFREDQADEYSSLRRELEQTIKNCRV 433
E+ + N M+ ++DL + Q++F + + ++Y L E +K +
Sbjct: 1517 EQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLE---ELKVRKS 1573
Query: 434 LSFKLKKT-ERKAD 446
LS KL KT ER A+
Sbjct: 1574 LSSKLTKTNERLAE 1587
Score = 38.3 bits (85), Expect = 0.28
Identities = 45/205 (21%), Positives = 92/205 (44%), Gaps = 19/205 (9%)
Query: 303 ANIDTANKYTTGRSSEVLKLQQKVNELTTHN---EDLRDEKKHLTQKIREIESELETRPS 359
A ++TA ++ LQ+++ + T E L+ KK L Q++ + S +E
Sbjct: 1416 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMV 1475
Query: 360 TEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSS 419
Q +Q +Q + A + + E+L KE+ Q+N + + + ++S
Sbjct: 1476 ELGQVKQYKQ-EIEERARQEIAEKL--------KEVNLFLQAQAASQENLEQFRENNFAS 1526
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELE 479
++ ++E IK+ K+K ++ ++ E EK +++ LE + R++ +L
Sbjct: 1527 MKSQMELRIKDLESELSKIKTSQEDFNKTELEK--YKQLYLE-----ELKVRKSLSSKLT 1579
Query: 480 QEVARSTEVALRLQRELAEANSKFT 504
+ R EV +L E ++ S FT
Sbjct: 1580 KTNERLAEVNTKLLVEKQQSRSLFT 1604
Score = 35.5 bits (78), Expect = 2.0
Identities = 35/195 (17%), Positives = 81/195 (41%), Gaps = 5/195 (2%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
++ KL+ K+++LT E + HL K + ++ EL + + + + ++++ + KL
Sbjct: 1403 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKL--- 1459
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELE-QTIKNCRVLSF 436
E L E EL + +++ R++ A++ + L+ Q + F
Sbjct: 1460 EQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQF 1519
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+ Q+E + E +L +I + + +++ +Q +V L +L
Sbjct: 1520 RENNFASMKSQMELRIKDLESELSKIKTSQEDFNK-TELEKYKQLYLEELKVRKSLSSKL 1578
Query: 497 AEANSKFTGSNPSLM 511
+ N + N L+
Sbjct: 1579 TKTNERLAEVNTKLL 1593
Score = 34.7 bits (76), Expect = 3.4
Identities = 45/275 (16%), Positives = 108/275 (39%), Gaps = 15/275 (5%)
Query: 1233 LQARFIKTESKFITLEAEM---RDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
L + K E K L+ E+ +++K+ E++ E + + + Q E+ R+ +
Sbjct: 754 LTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQ-EEEKRRNADT 812
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
Y++ + E + L +++L ++ + E + L
Sbjct: 813 LYEKIREQLRRKEEQYRKEVEVKQQLELS--LQTLEMELRTVKSNLNQVVQERNDAQRQL 870
Query: 1350 AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD---LQSERKKLDRMRIAHDKDVKNKD 1406
++ +N E K+++++ E K L +++
Sbjct: 871 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLR 930
Query: 1407 AELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLE 1466
E+ T+K + + E+ K + E ++ ++T+K+ E +L ++Y G+ +L
Sbjct: 931 LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQY---NGRLSVLT 987
Query: 1467 EEHVVTKARLTVE---KEQAQGELLHVQKELSTAL 1498
E+ + ++L E KE+ + E+ L+ A+
Sbjct: 988 AENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI 1022
>BC132784-1|AAI32785.1| 1116|Homo sapiens ELKS/RAB6-interacting/CAST
family member 1 protein.
Length = 1116
Score = 77.4 bits (182), Expect = 5e-13
Identities = 161/822 (19%), Positives = 346/822 (42%), Gaps = 82/822 (9%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D+ + + Q Q++ + +E D+LRK E E + S + +I T ++ E
Sbjct: 148 DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSS----SMNSIKTF--WSPELKKERALR 201
Query: 323 QQKVNELTTHNEDLR---DEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
+ + +++T E R +E +H+ I+ ++ EL + +Q R
Sbjct: 202 KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261
Query: 380 LCEE----LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
L EE L E+E KEL L M+ E Q ++ +++ ++ +
Sbjct: 262 LTEENFQRLHAEHERQAKELFLLRKTLEEMELRI-ETQKQTLNARDESIKKLLEMLQSKG 320
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
K TE ++ + AE E + + + ++EN + L +E+ R E
Sbjct: 321 LSAKATEEDHERTRR-LAEAEMHVHHLESLLEQKEKENSM--LREEMHRRFE-------- 369
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG-GSQEDPAQLLRDLQDSLEREADLRE 554
N+ + +L V + + K+S S+ RG E+ Q+L+ +L E + E
Sbjct: 370 ----NAPDSAKTKALQTVIEMKDSKIS--SMERGLRDLEEEIQMLKS-NGALSTE-EREE 421
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE 614
+++ E ++ K + K+ ++ + E + +Q + I S++
Sbjct: 422 EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWE--ELKKKAAGLQAE-IGQVKQELSRK 478
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
++ L T QF ++ + ++ AA ++ + ++L L+L++ T
Sbjct: 479 DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR-AAILQTEVDALRLRLEEKETM 537
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
NK + + + +EK T + ++K +L++ E++ VL++K+E L++
Sbjct: 538 L-----------NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ 586
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEV 789
+KQ+ L ++ S+ + ++T +LTT LAE ER+K D +
Sbjct: 587 LRDKEKQMSSLKERVKSLQADTTNTDT----ALTTLEEALAEKERTIERLKEQRDRDERE 642
Query: 790 RKKLIEK-ERDCERLHAELSLAQ----KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
+++ I+ ++D + L ++SL Q +K +L+ + AS + LK+ ++ E
Sbjct: 643 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE-HASSLASSGLKKDSRLKTLEI 701
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
++ + K + L+ +++ + L+ A SD+ L ++ T+ ++E +A A++
Sbjct: 702 ALEQKKEECLKMESQLKKAHEAALE--ARASPEMSDRIQHLE-REITRYKDESSKAQAEV 758
Query: 905 KELEMI---CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
L I ++EK++K + E ++ D K +
Sbjct: 759 DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE 818
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGE-MYVVMKNAGLSGKEMTAK 1020
+L D +Q+ + + KK +E+LE + E + + + + +E +A+
Sbjct: 819 DNLNDSSQQ-LQDSLRKK----------DDRIEELEEALRESVQITAEREMVLAQEESAR 867
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
T EK+++E+ + K E + K +L + L + L
Sbjct: 868 TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 909
Score = 50.4 bits (115), Expect = 6e-05
Identities = 84/421 (19%), Positives = 170/421 (40%), Gaps = 41/421 (9%)
Query: 182 EKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGG 241
EKE +IE+ +E+R + ++ E+ YK + K+ V+ L + + ++ L
Sbjct: 624 EKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLD------ 677
Query: 242 PXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR 301
L + Q + E LK E + + +E S + R
Sbjct: 678 -LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 736
Query: 302 LANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE 361
+ +++ + T E K Q +V+ L +++ +EK +KI E+E +++ +
Sbjct: 737 IQHLE---REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV 793
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
A + EQ+ K A ++++E + L D +QD+ R+ + D L
Sbjct: 794 ANLKHKEQVEKKKSA------QMLEEARRREDNLND---SSQQLQDSLRK-KDDRIEELE 843
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE 481
L ++++ + E Q E + EK++ E++ M E +ELE
Sbjct: 844 EALRESVQ-------ITAEREMVLAQEESARTNAEKQVEELL-----MAMEKVKQELESM 891
Query: 482 VARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
A+ + Q+ LAE + T K + E +++ + +L S++D L +
Sbjct: 892 KAKLSST----QQSLAEKETHLTNLRAERRKHLE-EVLEMKQEALLAAISEKDANIALLE 946
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L S ++ + L+ ++ +Q+ T ++M DN D H + +N +
Sbjct: 947 LSSSKKKTQEEVAALKREKDRLV--QQLKQQTQNRMKLMADNYE--DDHFKSSHSNQTNH 1002
Query: 602 K 602
K
Sbjct: 1003 K 1003
Score = 49.6 bits (113), Expect = 1e-04
Identities = 98/570 (17%), Positives = 205/570 (35%), Gaps = 39/570 (6%)
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKD 1273
+L T + + + ++K L AR + L+++ KA E+ + +A +
Sbjct: 283 LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR--LAEAE 340
Query: 1274 VHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+H+ LE L Q K E + E + R Q + K+ E
Sbjct: 341 MHVHHLESLLEQ----KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+ E+ LKS+ A S + +NK ++L +L S+ + +
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEE 456
Query: 1394 MR---------IAHDK-DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ-----EYE 1438
++ I K ++ KD EL L+ KL+ L + I LK+ E
Sbjct: 457 LKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR 516
Query: 1439 ETVKKLE-HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
+ + E +L L E E + K ++ K E + L +++++
Sbjct: 517 AAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVL 576
Query: 1498 LGEIKTLQEKLGTESAAWNTEK----------TEMQNSIASLQERLCGGGWEVERARLNA 1547
+I+ LQE+L + ++ K T ++ +L+E L +ER +
Sbjct: 577 QKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQR 636
Query: 1548 RLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXX 1607
D+RE++ N ++D+ + +
Sbjct: 637 DRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL 696
Query: 1608 XXXXXXXIEQSEKARKAEITDTKTRYEGQMNT-----MRDELKSLHNQVSRFRRERDNYK 1662
++ E+ K E + K +E + M D ++ L +++R++ E +
Sbjct: 697 KTLEIALEQKKEECLKME-SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 755
Query: 1663 QMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLA 1722
++ + + E++N +K+ + + + ++ KVA L+ + + + + A
Sbjct: 756 AEVDRLLEILKEVEN-EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
Query: 1723 SKLNTELVSEKSSAEVRLAEMQSRLNEYEE 1752
+ L + L + R+ E EE
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEELEE 844
Score = 48.8 bits (111), Expect = 2e-04
Identities = 158/822 (19%), Positives = 323/822 (39%), Gaps = 91/822 (11%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKT-----LIKSRSLDASDQQNVDL-KR 835
L+ ++ EV ++ +D E ++LS + KT L K R+L + + + K
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK--ALDLNTKKTTQL 893
Q +V+++E ++ Q+L+ ++L+ + QL + S R+ + +L + +L
Sbjct: 214 QYRVVQEENQHMQMTIQALQ---DELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
Query: 894 ----ENELKEA--LAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
E + KE L K ++E+E+ + +K R E+ KK + L+SK
Sbjct: 271 HAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEMLQSKGLSAKATEED 329
Query: 947 XXXXXXXXXXXQAT--LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L+SL + +K + + + + + +
Sbjct: 330 HERTRRLAEAEMHVHHLESLLEQKEKE------NSMLREEMHRRFENAPDSAKTKALQTV 383
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ MK++ +S E + LE+EI ++S + + E E +++ + K + K+E
Sbjct: 384 IEMKDSKISSMERGLRD-LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQ 442
Query: 1065 DKDVFANK---YKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
K+ ++K ++ L+ + + L + + +E+ ++ ++ L L+ T+ SD
Sbjct: 443 LKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN---QFSDS 499
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+VD ++K +L + KTK+I D
Sbjct: 500 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK---KTKQIQDMAEEKGTQA 556
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
++ L ++ +V L + + LQ + E
Sbjct: 557 GEIHDLKDMLDVKERKVNV-------------------------LQKKIENLQEQLRDKE 591
Query: 1242 SKFITLEAEMRDLKADYENK---ITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPV 1298
+ +L+ ++ L+AD N +T+LE +A K+ I++L++ D+ DE
Sbjct: 592 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQ-----RDR-DEREKQE 645
Query: 1299 EMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXX 1358
E+ + Q +L+ + L + + A+ L + LK D ++L+
Sbjct: 646 EIDNYKKDLKDLKEKVSLLQGDLSEKEASL--LDLKEHASSLASSGLKKD-SRLKTLEIA 702
Query: 1359 XXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-----IAHDKDVKNK-DAELATL 1412
S + KA E + ++ + DR++ I KD +K AE+ L
Sbjct: 703 LEQKKEECLKMESQLK-KAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRL 761
Query: 1413 KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVT 1472
LK +E K+I EL+++ ++ KK+ + L+ E E ++LEE
Sbjct: 762 LEILKEVENEKNDKDKKIAELERQVKDQNKKVAN---LKHKEQVEKKKSAQMLEEAR-RR 817
Query: 1473 KARLTVEKEQAQGELLHVQ---KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASL 1529
+ L +Q Q L +EL AL E + + A + +T + + L
Sbjct: 818 EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL 877
Query: 1530 QERLCGGGWEVE--RARLNA-RLDQRERELRAANDRRDVLEH 1568
+ E+E +A+L++ + E+E N R + +H
Sbjct: 878 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKH 919
Score = 36.3 bits (80), Expect = 1.1
Identities = 71/392 (18%), Positives = 143/392 (36%), Gaps = 29/392 (7%)
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKI-----LEQNSGA---GAKRITELK 1434
DLQ++ K++ R KDV+ K+++L++ +K L++ A +IT K
Sbjct: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYEL----LEEEHVVTKARLTVEKEQAQGELLHV 1490
++Y ++ +H +A +EL + +L ++ T E + + LH
Sbjct: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Query: 1491 Q-----KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
+ KEL ++ ++ ++ T+ N ++ + LQ + E
Sbjct: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
Query: 1546 NARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
RL + E + + E + D + +Q
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 1606 XXXXXXXXXIEQSEKARKAEITDTKTRYE--GQMNTMRDELKSLHNQVSRFRRERDNYKQ 1663
E+ + + T+ R E QM R K + N+V + + E + +
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEA 452
Query: 1664 MLEAAQKSMA--EIKNGDKSARIHRNSIS----STDEEEYRNKVALLEQQVACLEDELCE 1717
E +K A + + G + R T E N+ + +Q + L++ L
Sbjct: 453 QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 512
Query: 1718 SRLLASKLNTELVSEKSSAEVRLAEMQSRLNE 1749
A+ L TE+ + +RL E ++ LN+
Sbjct: 513 KEQRAAILQTEV----DALRLRLEEKETMLNK 540
>BC132782-1|AAI32783.1| 1116|Homo sapiens ELKS/RAB6-interacting/CAST
family member 1 protein.
Length = 1116
Score = 77.4 bits (182), Expect = 5e-13
Identities = 161/822 (19%), Positives = 346/822 (42%), Gaps = 82/822 (9%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D+ + + Q Q++ + +E D+LRK E E + S + +I T ++ E
Sbjct: 148 DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSS----SMNSIKTF--WSPELKKERALR 201
Query: 323 QQKVNELTTHNEDLR---DEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
+ + +++T E R +E +H+ I+ ++ EL + +Q R
Sbjct: 202 KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261
Query: 380 LCEE----LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
L EE L E+E KEL L M+ E Q ++ +++ ++ +
Sbjct: 262 LTEENFQRLHAEHERQAKELFLLRKTLEEMELRI-ETQKQTLNARDESIKKLLEMLQSKG 320
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
K TE ++ + AE E + + + ++EN + L +E+ R E
Sbjct: 321 LSAKATEEDHERTRR-LAEAEMHVHHLESLLEQKEKENSM--LREEMHRRFE-------- 369
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG-GSQEDPAQLLRDLQDSLEREADLRE 554
N+ + +L V + + K+S S+ RG E+ Q+L+ +L E + E
Sbjct: 370 ----NAPDSAKTKALQTVIEMKDSKIS--SMERGLRDLEEEIQMLKS-NGALSTE-EREE 421
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE 614
+++ E ++ K + K+ ++ + E + +Q + I S++
Sbjct: 422 EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWE--ELKKKAAGLQAE-IGQVKQELSRK 478
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
++ L T QF ++ + ++ AA ++ + ++L L+L++ T
Sbjct: 479 DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR-AAILQTEVDALRLRLEEKETM 537
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
NK + + + +EK T + ++K +L++ E++ VL++K+E L++
Sbjct: 538 L-----------NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ 586
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEV 789
+KQ+ L ++ S+ + ++T +LTT LAE ER+K D +
Sbjct: 587 LRDKEKQMSSLKERVKSLQADTTNTDT----ALTTLEEALAEKERTIERLKEQRDRDERE 642
Query: 790 RKKLIEK-ERDCERLHAELSLAQ----KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
+++ I+ ++D + L ++SL Q +K +L+ + AS + LK+ ++ E
Sbjct: 643 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE-HASSLASSGLKKDSRLKTLEI 701
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
++ + K + L+ +++ + L+ A SD+ L ++ T+ ++E +A A++
Sbjct: 702 ALEQKKEECLKMESQLKKAHEAALE--ARASPEMSDRIQHLE-REITRYKDESSKAQAEV 758
Query: 905 KELEMI---CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
L I ++EK++K + E ++ D K +
Sbjct: 759 DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE 818
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGE-MYVVMKNAGLSGKEMTAK 1020
+L D +Q+ + + KK +E+LE + E + + + + +E +A+
Sbjct: 819 DNLNDSSQQ-LQDSLRKK----------DDRIEELEEALRESVQITAEREMVLAQEESAR 867
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
T EK+++E+ + K E + K +L + L + L
Sbjct: 868 TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 909
Score = 50.4 bits (115), Expect = 6e-05
Identities = 84/421 (19%), Positives = 170/421 (40%), Gaps = 41/421 (9%)
Query: 182 EKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGG 241
EKE +IE+ +E+R + ++ E+ YK + K+ V+ L + + ++ L
Sbjct: 624 EKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLD------ 677
Query: 242 PXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR 301
L + Q + E LK E + + +E S + R
Sbjct: 678 -LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 736
Query: 302 LANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE 361
+ +++ + T E K Q +V+ L +++ +EK +KI E+E +++ +
Sbjct: 737 IQHLE---REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV 793
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
A + EQ+ K A ++++E + L D +QD+ R+ + D L
Sbjct: 794 ANLKHKEQVEKKKSA------QMLEEARRREDNLND---SSQQLQDSLRK-KDDRIEELE 843
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE 481
L ++++ + E Q E + EK++ E++ M E +ELE
Sbjct: 844 EALRESVQ-------ITAEREMVLAQEESARTNAEKQVEELL-----MAMEKVKQELESM 891
Query: 482 VARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
A+ + Q+ LAE + T K + E +++ + +L S++D L +
Sbjct: 892 KAKLSST----QQSLAEKETHLTNLRAERRKHLE-EVLEMKQEALLAAISEKDANIALLE 946
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L S ++ + L+ ++ +Q+ T ++M DN D H + +N +
Sbjct: 947 LSSSKKKTQEEVAALKREKDRLV--QQLKQQTQNRMKLMADNYE--DDHFKSSHSNQTNH 1002
Query: 602 K 602
K
Sbjct: 1003 K 1003
Score = 49.6 bits (113), Expect = 1e-04
Identities = 98/570 (17%), Positives = 205/570 (35%), Gaps = 39/570 (6%)
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKD 1273
+L T + + + ++K L AR + L+++ KA E+ + +A +
Sbjct: 283 LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR--LAEAE 340
Query: 1274 VHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+H+ LE L Q K E + E + R Q + K+ E
Sbjct: 341 MHVHHLESLLEQ----KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+ E+ LKS+ A S + +NK ++L +L S+ + +
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEE 456
Query: 1394 MR---------IAHDK-DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ-----EYE 1438
++ I K ++ KD EL L+ KL+ L + I LK+ E
Sbjct: 457 LKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR 516
Query: 1439 ETVKKLE-HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
+ + E +L L E E + K ++ K E + L +++++
Sbjct: 517 AAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVL 576
Query: 1498 LGEIKTLQEKLGTESAAWNTEK----------TEMQNSIASLQERLCGGGWEVERARLNA 1547
+I+ LQE+L + ++ K T ++ +L+E L +ER +
Sbjct: 577 QKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQR 636
Query: 1548 RLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXX 1607
D+RE++ N ++D+ + +
Sbjct: 637 DRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL 696
Query: 1608 XXXXXXXIEQSEKARKAEITDTKTRYEGQMNT-----MRDELKSLHNQVSRFRRERDNYK 1662
++ E+ K E + K +E + M D ++ L +++R++ E +
Sbjct: 697 KTLEIALEQKKEECLKME-SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 755
Query: 1663 QMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLA 1722
++ + + E++N +K+ + + + ++ KVA L+ + + + + A
Sbjct: 756 AEVDRLLEILKEVEN-EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
Query: 1723 SKLNTELVSEKSSAEVRLAEMQSRLNEYEE 1752
+ L + L + R+ E EE
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEELEE 844
Score = 48.8 bits (111), Expect = 2e-04
Identities = 158/822 (19%), Positives = 323/822 (39%), Gaps = 91/822 (11%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKT-----LIKSRSLDASDQQNVDL-KR 835
L+ ++ EV ++ +D E ++LS + KT L K R+L + + + K
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK--ALDLNTKKTTQL 893
Q +V+++E ++ Q+L+ ++L+ + QL + S R+ + +L + +L
Sbjct: 214 QYRVVQEENQHMQMTIQALQ---DELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
Query: 894 ----ENELKEA--LAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
E + KE L K ++E+E+ + +K R E+ KK + L+SK
Sbjct: 271 HAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEMLQSKGLSAKATEED 329
Query: 947 XXXXXXXXXXXQAT--LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L+SL + +K + + + + + +
Sbjct: 330 HERTRRLAEAEMHVHHLESLLEQKEKE------NSMLREEMHRRFENAPDSAKTKALQTV 383
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ MK++ +S E + LE+EI ++S + + E E +++ + K + K+E
Sbjct: 384 IEMKDSKISSMERGLRD-LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQ 442
Query: 1065 DKDVFANK---YKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
K+ ++K ++ L+ + + L + + +E+ ++ ++ L L+ T+ SD
Sbjct: 443 LKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN---QFSDS 499
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+VD ++K +L + KTK+I D
Sbjct: 500 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK---KTKQIQDMAEEKGTQA 556
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
++ L ++ +V L + + LQ + E
Sbjct: 557 GEIHDLKDMLDVKERKVNV-------------------------LQKKIENLQEQLRDKE 591
Query: 1242 SKFITLEAEMRDLKADYENK---ITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPV 1298
+ +L+ ++ L+AD N +T+LE +A K+ I++L++ D+ DE
Sbjct: 592 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQ-----RDR-DEREKQE 645
Query: 1299 EMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXX 1358
E+ + Q +L+ + L + + A+ L + LK D ++L+
Sbjct: 646 EIDNYKKDLKDLKEKVSLLQGDLSEKEASL--LDLKEHASSLASSGLKKD-SRLKTLEIA 702
Query: 1359 XXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-----IAHDKDVKNK-DAELATL 1412
S + KA E + ++ + DR++ I KD +K AE+ L
Sbjct: 703 LEQKKEECLKMESQLK-KAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRL 761
Query: 1413 KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVT 1472
LK +E K+I EL+++ ++ KK+ + L+ E E ++LEE
Sbjct: 762 LEILKEVENEKNDKDKKIAELERQVKDQNKKVAN---LKHKEQVEKKKSAQMLEEAR-RR 817
Query: 1473 KARLTVEKEQAQGELLHVQ---KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASL 1529
+ L +Q Q L +EL AL E + + A + +T + + L
Sbjct: 818 EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL 877
Query: 1530 QERLCGGGWEVE--RARLNA-RLDQRERELRAANDRRDVLEH 1568
+ E+E +A+L++ + E+E N R + +H
Sbjct: 878 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKH 919
Score = 36.3 bits (80), Expect = 1.1
Identities = 71/392 (18%), Positives = 143/392 (36%), Gaps = 29/392 (7%)
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKI-----LEQNSGA---GAKRITELK 1434
DLQ++ K++ R KDV+ K+++L++ +K L++ A +IT K
Sbjct: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYEL----LEEEHVVTKARLTVEKEQAQGELLHV 1490
++Y ++ +H +A +EL + +L ++ T E + + LH
Sbjct: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Query: 1491 Q-----KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
+ KEL ++ ++ ++ T+ N ++ + LQ + E
Sbjct: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
Query: 1546 NARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
RL + E + + E + D + +Q
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 1606 XXXXXXXXXIEQSEKARKAEITDTKTRYE--GQMNTMRDELKSLHNQVSRFRRERDNYKQ 1663
E+ + + T+ R E QM R K + N+V + + E + +
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEA 452
Query: 1664 MLEAAQKSMA--EIKNGDKSARIHRNSIS----STDEEEYRNKVALLEQQVACLEDELCE 1717
E +K A + + G + R T E N+ + +Q + L++ L
Sbjct: 453 QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 512
Query: 1718 SRLLASKLNTELVSEKSSAEVRLAEMQSRLNE 1749
A+ L TE+ + +RL E ++ LN+
Sbjct: 513 KEQRAAILQTEV----DALRLRLEEKETMLNK 540
>AB053471-1|BAC54110.1| 1116|Homo sapiens ELKS epsilon protein.
Length = 1116
Score = 77.4 bits (182), Expect = 5e-13
Identities = 161/822 (19%), Positives = 346/822 (42%), Gaps = 82/822 (9%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D+ + + Q Q++ + +E D+LRK E E + S + +I T ++ E
Sbjct: 148 DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSS----SMNSIKTF--WSPELKKERALR 201
Query: 323 QQKVNELTTHNEDLR---DEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
+ + +++T E R +E +H+ I+ ++ EL + +Q R
Sbjct: 202 KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261
Query: 380 LCEE----LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
L EE L E+E KEL L M+ E Q ++ +++ ++ +
Sbjct: 262 LTEENFQRLHAEHERQAKELFLLRKTLEEMELRI-ETQKQTLNARDESIKKLLEMLQSKG 320
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
K TE ++ + AE E + + + ++EN + L +E+ R E
Sbjct: 321 LSAKATEEDHERTRR-LAEAEMHVHHLESLLEQKEKENSM--LREEMHRRFE-------- 369
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG-GSQEDPAQLLRDLQDSLEREADLRE 554
N+ + +L V + + K+S S+ RG E+ Q+L+ +L E + E
Sbjct: 370 ----NAPDSAKTKALQTVIEMKDSKIS--SMERGLRDLEEEIQMLKS-NGALSTE-EREE 421
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE 614
+++ E ++ K + K+ ++ + E + +Q + I S++
Sbjct: 422 EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWE--ELKKKAAGLQAE-IGQVKQELSRK 478
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
++ L T QF ++ + ++ AA ++ + ++L L+L++ T
Sbjct: 479 DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR-AAILQTEVDALRLRLEEKETM 537
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
NK + + + +EK T + ++K +L++ E++ VL++K+E L++
Sbjct: 538 L-----------NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ 586
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEV 789
+KQ+ L ++ S+ + ++T +LTT LAE ER+K D +
Sbjct: 587 LRDKEKQMSSLKERVKSLQADTTNTDT----ALTTLEEALAEKERTIERLKEQRDRDERE 642
Query: 790 RKKLIEK-ERDCERLHAELSLAQ----KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
+++ I+ ++D + L ++SL Q +K +L+ + AS + LK+ ++ E
Sbjct: 643 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE-HASSLASSGLKKDSRLKTLEI 701
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
++ + K + L+ +++ + L+ A SD+ L ++ T+ ++E +A A++
Sbjct: 702 ALEQKKEECLKMESQLKKAHEAALE--ARASPEMSDRIQHLE-REITRYKDESSKAQAEV 758
Query: 905 KELEMI---CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
L I ++EK++K + E ++ D K +
Sbjct: 759 DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE 818
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGE-MYVVMKNAGLSGKEMTAK 1020
+L D +Q+ + + KK +E+LE + E + + + + +E +A+
Sbjct: 819 DNLNDSSQQ-LQDSLRKK----------DDRIEELEEALRESVQITAEREMVLAQEESAR 867
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
T EK+++E+ + K E + K +L + L + L
Sbjct: 868 TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 909
Score = 50.4 bits (115), Expect = 6e-05
Identities = 84/421 (19%), Positives = 170/421 (40%), Gaps = 41/421 (9%)
Query: 182 EKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGG 241
EKE +IE+ +E+R + ++ E+ YK + K+ V+ L + + ++ L
Sbjct: 624 EKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLD------ 677
Query: 242 PXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR 301
L + Q + E LK E + + +E S + R
Sbjct: 678 -LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 736
Query: 302 LANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE 361
+ +++ + T E K Q +V+ L +++ +EK +KI E+E +++ +
Sbjct: 737 IQHLE---REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV 793
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
A + EQ+ K A ++++E + L D +QD+ R+ + D L
Sbjct: 794 ANLKHKEQVEKKKSA------QMLEEARRREDNLND---SSQQLQDSLRK-KDDRIEELE 843
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE 481
L ++++ + E Q E + EK++ E++ M E +ELE
Sbjct: 844 EALRESVQ-------ITAEREMVLAQEESARTNAEKQVEELL-----MAMEKVKQELESM 891
Query: 482 VARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
A+ + Q+ LAE + T K + E +++ + +L S++D L +
Sbjct: 892 KAKLSST----QQSLAEKETHLTNLRAERRKHLE-EVLEMKQEALLAAISEKDANIALLE 946
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
L S ++ + L+ ++ +Q+ T ++M DN D H + +N +
Sbjct: 947 LSSSKKKTQEEVAALKREKDRLV--QQLKQQTQNRMKLMADNYE--DDHFKSSHSNQTNH 1002
Query: 602 K 602
K
Sbjct: 1003 K 1003
Score = 49.6 bits (113), Expect = 1e-04
Identities = 98/570 (17%), Positives = 205/570 (35%), Gaps = 39/570 (6%)
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKD 1273
+L T + + + ++K L AR + L+++ KA E+ + +A +
Sbjct: 283 LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR--LAEAE 340
Query: 1274 VHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+H+ LE L Q K E + E + R Q + K+ E
Sbjct: 341 MHVHHLESLLEQ----KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+ E+ LKS+ A S + +NK ++L +L S+ + +
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEE 456
Query: 1394 MR---------IAHDK-DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ-----EYE 1438
++ I K ++ KD EL L+ KL+ L + I LK+ E
Sbjct: 457 LKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR 516
Query: 1439 ETVKKLE-HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA 1497
+ + E +L L E E + K ++ K E + L +++++
Sbjct: 517 AAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVL 576
Query: 1498 LGEIKTLQEKLGTESAAWNTEK----------TEMQNSIASLQERLCGGGWEVERARLNA 1547
+I+ LQE+L + ++ K T ++ +L+E L +ER +
Sbjct: 577 QKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQR 636
Query: 1548 RLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXX 1607
D+RE++ N ++D+ + +
Sbjct: 637 DRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL 696
Query: 1608 XXXXXXXIEQSEKARKAEITDTKTRYEGQMNT-----MRDELKSLHNQVSRFRRERDNYK 1662
++ E+ K E + K +E + M D ++ L +++R++ E +
Sbjct: 697 KTLEIALEQKKEECLKME-SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 755
Query: 1663 QMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLA 1722
++ + + E++N +K+ + + + ++ KVA L+ + + + + A
Sbjct: 756 AEVDRLLEILKEVEN-EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
Query: 1723 SKLNTELVSEKSSAEVRLAEMQSRLNEYEE 1752
+ L + L + R+ E EE
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEELEE 844
Score = 48.8 bits (111), Expect = 2e-04
Identities = 158/822 (19%), Positives = 323/822 (39%), Gaps = 91/822 (11%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKT-----LIKSRSLDASDQQNVDL-KR 835
L+ ++ EV ++ +D E ++LS + KT L K R+L + + + K
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK--ALDLNTKKTTQL 893
Q +V+++E ++ Q+L+ ++L+ + QL + S R+ + +L + +L
Sbjct: 214 QYRVVQEENQHMQMTIQALQ---DELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
Query: 894 ----ENELKEA--LAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
E + KE L K ++E+E+ + +K R E+ KK + L+SK
Sbjct: 271 HAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEMLQSKGLSAKATEED 329
Query: 947 XXXXXXXXXXXQAT--LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L+SL + +K + + + + + +
Sbjct: 330 HERTRRLAEAEMHVHHLESLLEQKEKE------NSMLREEMHRRFENAPDSAKTKALQTV 383
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ MK++ +S E + LE+EI ++S + + E E +++ + K + K+E
Sbjct: 384 IEMKDSKISSMERGLRD-LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQ 442
Query: 1065 DKDVFANK---YKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
K+ ++K ++ L+ + + L + + +E+ ++ ++ L L+ T+ SD
Sbjct: 443 LKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN---QFSDS 499
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+VD ++K +L + KTK+I D
Sbjct: 500 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK---KTKQIQDMAEEKGTQA 556
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
++ L ++ +V L + + LQ + E
Sbjct: 557 GEIHDLKDMLDVKERKVNV-------------------------LQKKIENLQEQLRDKE 591
Query: 1242 SKFITLEAEMRDLKADYENK---ITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPV 1298
+ +L+ ++ L+AD N +T+LE +A K+ I++L++ D+ DE
Sbjct: 592 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQ-----RDR-DEREKQE 645
Query: 1299 EMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXX 1358
E+ + Q +L+ + L + + A+ L + LK D ++L+
Sbjct: 646 EIDNYKKDLKDLKEKVSLLQGDLSEKEASL--LDLKEHASSLASSGLKKD-SRLKTLEIA 702
Query: 1359 XXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-----IAHDKDVKNK-DAELATL 1412
S + KA E + ++ + DR++ I KD +K AE+ L
Sbjct: 703 LEQKKEECLKMESQLK-KAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRL 761
Query: 1413 KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVT 1472
LK +E K+I EL+++ ++ KK+ + L+ E E ++LEE
Sbjct: 762 LEILKEVENEKNDKDKKIAELERQVKDQNKKVAN---LKHKEQVEKKKSAQMLEEAR-RR 817
Query: 1473 KARLTVEKEQAQGELLHVQ---KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASL 1529
+ L +Q Q L +EL AL E + + A + +T + + L
Sbjct: 818 EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL 877
Query: 1530 QERLCGGGWEVE--RARLNA-RLDQRERELRAANDRRDVLEH 1568
+ E+E +A+L++ + E+E N R + +H
Sbjct: 878 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKH 919
Score = 36.3 bits (80), Expect = 1.1
Identities = 71/392 (18%), Positives = 143/392 (36%), Gaps = 29/392 (7%)
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKI-----LEQNSGA---GAKRITELK 1434
DLQ++ K++ R KDV+ K+++L++ +K L++ A +IT K
Sbjct: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYEL----LEEEHVVTKARLTVEKEQAQGELLHV 1490
++Y ++ +H +A +EL + +L ++ T E + + LH
Sbjct: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Query: 1491 Q-----KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
+ KEL ++ ++ ++ T+ N ++ + LQ + E
Sbjct: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
Query: 1546 NARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
RL + E + + E + D + +Q
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 1606 XXXXXXXXXIEQSEKARKAEITDTKTRYE--GQMNTMRDELKSLHNQVSRFRRERDNYKQ 1663
E+ + + T+ R E QM R K + N+V + + E + +
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEA 452
Query: 1664 MLEAAQKSMA--EIKNGDKSARIHRNSIS----STDEEEYRNKVALLEQQVACLEDELCE 1717
E +K A + + G + R T E N+ + +Q + L++ L
Sbjct: 453 QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 512
Query: 1718 SRLLASKLNTELVSEKSSAEVRLAEMQSRLNE 1749
A+ L TE+ + +RL E ++ LN+
Sbjct: 513 KEQRAAILQTEV----DALRLRLEEKETMLNK 540
>X66397-1|CAA47021.1| 2349|Homo sapiens Tpr protein.
Length = 2349
Score = 77.0 bits (181), Expect = 6e-13
Identities = 234/1292 (18%), Positives = 495/1292 (38%), Gaps = 113/1292 (8%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKE---KSDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
E QDQ+ K E + K + + KE K+ IL R+ + A K S ++ + +
Sbjct: 404 ETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMK 463
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAK--LLAAETLC 381
++ L + + L + R +E ++ + ++E+ R + E
Sbjct: 464 EIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQA-DEYSSLRRELEQTIKNCRVLSFKLKK 440
++ +E + + L Q N R A E R EQ + ++ +LK
Sbjct: 524 ADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK- 582
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE-LAEA 499
E +LEQ + + ++ ++V D + R+ + + ++++T VA+ L L +
Sbjct: 583 LESALTELEQLRKSRQHQM-QLV---DSIVRQRDMYRIL--LSQTTGVAIPLHASSLDDV 636
Query: 500 NSKFTGSNPSL---MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLEREADLREQ 555
+ T PS + P P V S ++ + + ++ + + + E E EQ
Sbjct: 637 SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ 696
Query: 556 LRNAEEETANCKQVNPP--TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
L +E+ + + N T LD ++ ++ S+ + +T +
Sbjct: 697 LEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQ 756
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMAT 673
E+ I+ T++ + + ++ + A NL+K ++ L Q + +
Sbjct: 757 EQI------INTMTQDLRGANEKLAVA---EVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
Query: 674 KARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQ 733
+ R + L T N +I+ + E ET + ++++ L E E + L++K+E +
Sbjct: 808 EQRGQNLLLT---NLQTIQGILERSETETKQRLSSQIEKL----EHEISHLKKKLENEVE 860
Query: 734 DKEALKKQ--VKELTSKISSVTKTSAGSNT-----TARRSLTTNSNKLAEERVKVLEDEI 786
+ L + V+ L +K T+T+ NT A++ + T L+ V+V
Sbjct: 861 QRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSS 920
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTL---IKSRSLDASDQQNV--DLKRQLQVIE 841
K + D + L ++L +++ L +K+ + + Q + L+ L +
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK 980
Query: 842 QEASVLRAKTQSLEADNEKLQT--ENKKLQLLKNAKSLRSDKALDLNT--------KKT- 890
Q +R + ++ + QT E K +++ K + L+ DK + + KKT
Sbjct: 981 QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL 1040
Query: 891 TQLENELKEALAKI-------KELEMICQDE---------KSEKK-------VRFTEATK 927
+ ++NE++EAL + ++ CQ++ K E++ V +A K
Sbjct: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAK 1100
Query: 928 KETDTLKS-KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTK 986
++ + S +Q + + LKD+ K + +
Sbjct: 1101 EQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLH 1160
Query: 987 LQLKKMVEDLECEIGEMYVVMKNAGLS--GK------EMTAKTKLEKEIDEIRSKLSKND 1038
Q++K+ + + + E N LS GK E+ + EKEI E R ++++ +
Sbjct: 1161 DQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVE 1220
Query: 1039 S-EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNR 1097
S + L+ E+ +L+D + E +K K A E + + E K
Sbjct: 1221 SLRYRQRVELLERELQELED-SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKML 1279
Query: 1098 EAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN 1157
+ +L DL+ + + + ++ K + +N
Sbjct: 1280 REEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
Query: 1158 KLL--KEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVL 1215
+ L ++ T++ +++ +++ K + L
Sbjct: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
Query: 1216 ANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVH 1275
++ E + + +L A+ I + K T+ +++ + Y+ T E A +D
Sbjct: 1400 KEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI-TQVKKIGRRYK---TQYEELKAQQD-- 1453
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
K +E + Q++ D ++ S EM E++ + ++ N + L + E E+
Sbjct: 1454 -KVMETSA-QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
+ + QL+S+L++L + E K ++ +S +
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS--------K 1563
Query: 1396 IAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
IAH VK++ E LK + L+Q RIT LK +YE + +LE L +
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQER 1623
Query: 1455 YEELTGKYELLEEEHVVTKARLTVEKEQAQGE 1486
+ E + + + + ++T++ A GE
Sbjct: 1624 HLEQRDEPQEPSNKVPEQQRQITLKTTPASGE 1655
Score = 67.3 bits (157), Expect = 5e-10
Identities = 166/837 (19%), Positives = 356/837 (42%), Gaps = 88/837 (10%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI--LLRRLANIDTANKYTTGRSSE 318
L+ +N++ Q +E + E + ++ ++EK + +I L ++L N + ++T R+ +
Sbjct: 814 LLLTNLQTIQGILE--RSETETKQRLSSQIEKLEHEISHLKKKLEN-EVEQRHTLTRNLD 870
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAA 377
V L K +L T + K+ L +EI + + + E Q Q Q K +
Sbjct: 871 VQLLDTK-RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPS 929
Query: 378 ETL-CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYS---SLRRELEQTIKNCRV 433
++L+ + ++++ DL N + QA S SL +E + T + +
Sbjct: 930 NKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
+ +LK++ QLE++ E EK+ E+ D +R I+ +EQ+++ + +Q
Sbjct: 990 IEVRLKESAEFQTQLEKKLMEVEKEKQEL---QDDKRR--AIESMEQQLSELKKTLSSVQ 1044
Query: 494 RELAEANSKFTG--SNPSLMKVPQPETVKVSRSSLTRGGSQ----EDPAQLLRDLQDSLE 547
E+ EA + + SN + E K++ + + + + L+ ++ +
Sbjct: 1045 NEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
Query: 548 READLREQL----RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM 603
+ A +R+ L + AE + CK ++ +++ M + V+ + E + QN++
Sbjct: 1105 KMASVRQHLEETTQKAESQLLECK----ASWEERERMLKDEVSKCVCRCEDLEK--QNRL 1158
Query: 604 IH------AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+H + +S ++ PL++ + E L L + +T V
Sbjct: 1159 LHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRR--EKEIAETRFEV 1216
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE-TANDNDEKETDEADPAEMKLLLEL 716
+ ESL + + + ++L + A + ++ TA + E M +++E
Sbjct: 1217 AQ-VESLRYRQRVELLERELQELEDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMET 1275
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
N+ +LR + E LEQD + ++ +V++L ++ + A + + + + KL E
Sbjct: 1276 NK----MLREEKERLEQDLQQMQAKVRKL--ELDILPLQEANAELSEKSGMLQAEKKLLE 1329
Query: 777 ERVK------------VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
E VK + + +E RK L EKE +R+ +L+ + K I +
Sbjct: 1330 EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ-QLTEEIGRLKAEIARSNAS 1388
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
++ QN+ +Q ++++ + +R + ++++ D + K + + + K++ K +
Sbjct: 1389 LTNNQNL-----IQSLKEDLNKVRTEKETIQKD-----LDAKIIDIQEKVKTITQVKKIG 1438
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K TQ E ELK K+ E + E+ V E + + +TL +
Sbjct: 1439 RRYK--TQYE-ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELK-ETLNQAETKSKSLE 1494
Query: 945 XXXXXXXXXXXXXQATLKSLKDDA--QKSFKPRIPKKPTDLTT-KLQLKKMVEDLECEIG 1001
+ ++L++ +S R+ + D TT + QL++ + + E +
Sbjct: 1495 SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
Query: 1002 EMYVVMKN--AGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK 1056
+ V K+ A L+G K +L KE +E++ + + +K+ L I LK
Sbjct: 1555 KAIVAAKSKIAHLAG----VKDQLTKENEELKQR----NGALDQQKDELDVRITALK 1603
Score = 62.9 bits (146), Expect = 1e-08
Identities = 254/1309 (19%), Positives = 511/1309 (39%), Gaps = 116/1309 (8%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREI-ESELETRPSTEAQTRQIEQLRAKLLAAET 379
++ +K+ L E+ D +K + E EL T A +I + KL
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
E D+ K E + + + E +A R E E+ K LS KL+
Sbjct: 401 AYVETQDQLLLEKLENKRINKYLDEIVKEV-EAKAPILKRQREEYERAQKAVASLSVKLE 459
Query: 440 KTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ ++ +L+++ KA + +LE D + E ++K+L Q++ L ++ E A
Sbjct: 460 QAMKEIQRLQEDTDKANKQSSVLE----RDNRRMEIQVKDLSQQIR-----VLLMELEEA 510
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
N S + V +S+ ++ +E L + Q L +L E
Sbjct: 511 RGNHVIRDEEVSSADISSSSEV-ISQHLVSYRNIEE----LQQQNQRLLVALRELGETRE 565
Query: 558 NAEEETANCKQVNPPTFLDKQVMT-DNIVTCDIHESETVTNSIQNKMIH--------AAS 608
E+ET + K L+ + + + H+ + V + ++ + ++ +
Sbjct: 566 REEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVA 625
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPY-LSIFNHMAANNLRKTAARVEEDNESLLLQ 667
P D L+ T P + + A + +++E E+
Sbjct: 626 IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENY--- 682
Query: 668 LKKMATKARSRKLSPTPPANKLSIETAN--DNDEKETDEADPAEMKLLLELNEQEATVLR 725
KK KA + K+ KL + + + K + + D A + E+ + R
Sbjct: 683 -KK--EKAENEKIQ-NEQLEKLQEQVTDLRSQNTKISTQLDFASKRY--EMLQDNVEGYR 736
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT-ARRSLTTNSNKLAEERVKVLED 784
R++ L + + L ++ I+++T+ G+N A + + K +E +K+ E
Sbjct: 737 REITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEV 796
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
+ + R+ L+ ++R L L Q I RS + Q+ L Q++ +E E
Sbjct: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQG-----ILERSETETKQR---LSSQIEKLEHEI 848
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAK 903
S L+ K ++ E + T N +QLL + L ++ L LNTK+ + + E+
Sbjct: 849 SHLKKKLEN-EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH 907
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSK----QXXXXXXXXXXXXXXXXXXXXQA 959
+ +E+ + S++ + + K++ D L S+ + QA
Sbjct: 908 LSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQA 967
Query: 960 TLKSLK----------DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ SL+ ++ +K+ + R+ K+ + T+L+ KK++E +E E E+ +
Sbjct: 968 MVTSLEESLNKEKQVTEEVRKNIEVRL-KESAEFQTQLE-KKLME-VEKEKQELQDDKRR 1024
Query: 1010 AGLSGKEMTAKTK--LEKEIDEIRSKLSKNDSEFTNEK--NRLQTEIAKLK-DVNAKLEG 1064
A S ++ ++ K L +E++ L + + +NE+ R E AK+ + K E
Sbjct: 1025 AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYER 1084
Query: 1065 DKDVFANKYKALENENSNLSNQCKT---LTEEMKNREAQINKLSADL-KNATSLQTTMSD 1120
+ + A +AL+ +S L E + E+Q+ + A + L+ +S
Sbjct: 1085 ELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSK 1144
Query: 1121 CMXXXXXXXXXXXXXXXXXXXXXXQVDNYTK--IDQDKNKLLKEVGDKTKKIGDXXXXXX 1178
C+ +V K + N L E G ++I +
Sbjct: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
Query: 1179 XXXXXCK-RIE-KQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR-RLSIELTSEKDELQA 1235
+ R E Q+ + + R + + A + +++ + ++ +EL
Sbjct: 1205 REKEIAETRFEVAQVESLRYRQRVELLERELQELEDSLNAEREKVQVTAKTMAQHEELMK 1264
Query: 1236 RFIKTESKFITLEAE--MRDLKADYENKITSLESTIAAKDVHIKQLEDA---LRQTTNDK 1290
KTE+ + +E +R+ K E + +++ + ++ I L++A L + +
Sbjct: 1265 ---KTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGML 1321
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL--EMAQLKSD 1348
E E V+ D K+ EK +L E+ +LK++
Sbjct: 1322 QAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAE 1381
Query: 1349 LAK----LENXXXXXXXXXXXXXXXSSYWENKAKELDT---DLQSERKKLDRMRIAHDKD 1401
+A+ L N + E K+LD D+Q + K + +++ +
Sbjct: 1382 IARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK-KIGRR 1440
Query: 1402 VKNKDAELATLKGK-LKILEQNSGAGAKRITELK--QEYEETVKKLEHSLALEKAEYEEL 1458
K + EL + K ++ Q+SG ++ ++ QE +ET+ + E +++ E L
Sbjct: 1441 YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500
Query: 1459 TGKYELLEEEHVVTKAR-LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNT 1517
+ L E+E T+AR L + Q Q EL ++++L + +T QE+ +
Sbjct: 1501 --QKTLSEKE---TEARNLQEQTVQLQSELSRLRQDL-----QDRTTQEEQLRQQITEKE 1550
Query: 1518 EKTEMQNSIASLQERLCG-GGWEVERARLNARLDQRERELRAANDRRDV 1565
EKT + +I + + ++ G + + + N L QR L D DV
Sbjct: 1551 EKT--RKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDV 1597
Score = 59.3 bits (137), Expect = 1e-07
Identities = 208/1204 (17%), Positives = 460/1204 (38%), Gaps = 105/1204 (8%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAKLLAAETLC 381
Q +++ L +E + E + Q+ EIE L ++ +TR+ + LR +L
Sbjct: 33 QSEIDGLKGRHEKFKVESE---QQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQL 89
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+ L ++N++++ +D +E+ E L R E+ + L+ +K+
Sbjct: 90 KALTEKNKELEIA-QDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRL 148
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRI---KEL--EQEVARSTEVALRLQRE 495
K + K E + KL E+ ++ RE R+ KEL Q +TE+ +
Sbjct: 149 NEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL 208
Query: 496 LAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
LA K G+ +K + + +VSR G + L + ++D L + + +E
Sbjct: 209 LALGREK--GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE 614
Q + EE+ N L+ + N+ +SE +N + + KE
Sbjct: 267 QQASMEEKFHN--------ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKL--LKE 316
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA-- 672
++ D E Q + + + +E N+ L +K A
Sbjct: 317 AGEANKAIQDHLLEVEQSKDQM------EKEMLEKIGRLEKELENANDLLSATKRKGAIL 370
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL-NEQEATVLRRKVEEL 731
++ +SPT A ++ E + + LL +L N++ L V+E+
Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
E LK+Q +E +V SL+ + +E ++ L+++ D+ K
Sbjct: 431 EAKAPILKRQREEYERAQKAVA------------SLSVKLEQAMKE-IQRLQEDTDKANK 477
Query: 792 KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+ ERD R+ ++ ++ + L+ + D + I + V+
Sbjct: 478 QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHL 537
Query: 852 QSLEADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
S + E+LQ +N++L + L+ R + + + K T+L+ +L+ AL ++++L
Sbjct: 538 VSYR-NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLR-- 594
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ + +++ ++ ++ D + +T K + +
Sbjct: 595 ---KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK--RPSTSQ 649
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK--NAGLSGKEMTAKTKLEKEID 1028
+ P + T ++ K ++ L+ EI E Y K N + +++ KL++++
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQ-EIFENYKKEKAENEKIQNEQL---EKLQEQVT 705
Query: 1029 EIRSKLSK--NDSEFTNEKNRL--------QTEIAKLKDVNAKL----EGDKDVFANKYK 1074
++RS+ +K +F +++ + + EI L + N KL + + + +
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXX 1134
L N L+ + E +K +E ++ KLS +++ + ++ +++
Sbjct: 766 DLRGANEKLA-VAEVRAENLK-KEKEMLKLS-EVRLSQQRESLLAE---QRGQNLLLTNL 819
Query: 1135 XXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK----RIEKQ 1190
+ + ++ KL E+ KK+ + ++Q
Sbjct: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI-TLEA 1249
L T + + L + +++ S+ + + + + + L +
Sbjct: 880 LDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939
Query: 1250 EMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
++R E ++ L+ + +++Q + A+ + + ++ E V
Sbjct: 940 QLRQT----EEQVNDLKERLKTSTSNVEQYQ-AMVTSLEESLNKEKQVTEEVRKNIEVRL 994
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
Q E +++ EK E + + + ++ L++L+
Sbjct: 995 KESAEFQTQLEKKLMEVEKEKQELQDDKRR-AIESMEQQLSELKKTLSSVQNEVQEALQR 1053
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
+S + ++ D Q + K + +++++ A++ L+ EQ S +
Sbjct: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA---AKEQVS-----K 1105
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLH 1489
+ ++Q EET +K E L KA +EE + +L++E V+K E + Q LLH
Sbjct: 1106 MASVRQHLEETTQKAESQLLECKASWEE---RERMLKDE--VSKCVCRCEDLEKQNRLLH 1160
Query: 1490 VQKE 1493
Q E
Sbjct: 1161 DQIE 1164
Score = 52.8 bits (121), Expect = 1e-05
Identities = 178/1055 (16%), Positives = 379/1055 (35%), Gaps = 73/1055 (6%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
E+K LE ++E + L ++ L+ E L+K V++L +K+ + A L
Sbjct: 221 ELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELN 280
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+ KL+ + + D+ K E R E LH L A + K I+ L+
Sbjct: 281 AHI-KLSN----LYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKA-IQDHLLEVEQS 334
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
++ K L+ I + L L A K +++ +L + + + +
Sbjct: 335 KDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEE-ELAAMSPTAAAVAKIVKPGM 393
Query: 889 KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
K T+L N E ++ LE + ++ + + + LK ++
Sbjct: 394 KLTELYNAYVETQDQLL-LEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
++ L++D K+ K + + ++Q+K + + + + E+
Sbjct: 453 SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512
Query: 1009 NAGLSGKEMT-AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKD 1067
N + +E++ A E+ +N E + RL + +L + + E ++
Sbjct: 513 NHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE--QE 570
Query: 1068 VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL--SADLKNATSLQTTMSDCMXXX 1125
++K L+ + + + + L + +++ ++ + D+ QTT
Sbjct: 571 TTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHA 630
Query: 1126 XXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK 1185
V + ++ E K++ + +
Sbjct: 631 SSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENE 690
Query: 1186 RIE-KQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+I+ +QL +++VT Q + + L + + E+ + + +
Sbjct: 691 KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT 750
Query: 1245 ITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMR 1304
T + + + + ++ + +A +V + L+ +K S V + + R
Sbjct: 751 ATTQKQEQIINTMTQD-LRGANEKLAVAEVRAENLK-------KEKEMLKLSEVRLSQQR 802
Query: 1305 XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXX 1364
L + LE++E E+ +L S + KLE+
Sbjct: 803 ESLLAEQRGQNLLLTNLQTIQGILERSETETKQ------RLSSQIEKLEHEISHLKKKLE 856
Query: 1365 XXXXXSSYWENKAKELDTDLQSERKKLDRMRIAH--DKDV-KNKDAELATLKGKLKILE- 1420
+ LD L +++LD H K++ KN E+ATLK L +E
Sbjct: 857 NEVEQR---HTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
Query: 1421 -------QNSGAGAKR--------ITELKQEYEETVKKLEHSLALEKAEYEE----LTGK 1461
Q +G G +++L+Q EE V L+ L + E+ +T
Sbjct: 914 QVASQSSQRTGKGQPSNKEDVDDLVSQLRQT-EEQVNDLKERLKTSTSNVEQYQAMVTSL 972
Query: 1462 YELLEEEHVVTK-ARLTVE---KEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNT 1517
E L +E VT+ R +E KE A+ + ++K+L E + LQ+ +
Sbjct: 973 EESLNKEKQVTEEVRKNIEVRLKESAEFQT-QLEKKLMEVEKEKQELQDDKRRAIESMEQ 1031
Query: 1518 EKTEMQNSIASLQERLCGGGWEVERARLNARLDQRE--RELRAANDRRDVLEHHHDXXXX 1575
+ +E++ +++S+Q + A N + +R+ + + A + ++ E
Sbjct: 1032 QLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAA 1091
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
+++ +++ E+ E+ K E++ R E
Sbjct: 1092 DVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCED 1151
Query: 1636 ---QMNTMRDELKSLHNQVSRFRRE--RDNYKQMLEAAQKSMAEIKN------GDKSARI 1684
Q + D+++ L ++V +E + L KS +I +K
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE 1211
Query: 1685 HRNSISSTDEEEYRNKVALLEQQVACLEDELCESR 1719
R ++ + YR +V LLE+++ LED L R
Sbjct: 1212 TRFEVAQVESLRYRQRVELLERELQELEDSLNAER 1246
Score = 49.2 bits (112), Expect = 1e-04
Identities = 81/362 (22%), Positives = 146/362 (40%), Gaps = 26/362 (7%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR- 1284
L EK+ L ++ ++ T E+ L + N+I L+ + K + +LE+ +
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNG 242
Query: 1285 -QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE---KTEAESSAAKL 1340
+T+N+ + + + +++ +EL NA IKL K+ A+ S AK
Sbjct: 243 LKTSNEHLQKHVEDL-LTKLKEAKEQQASMEEKFHNEL-NAHIKLSNLYKSAADDSEAKS 300
Query: 1341 -EMAQLKSDLAK-LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL----DRM 1394
E+ + +L K L+ + KE+ + K+L D +
Sbjct: 301 NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL 360
Query: 1395 RIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
K + ELA + + + G K +TEL Y ET + L LEK E
Sbjct: 361 SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMK-LTELYNAYVET----QDQLLLEKLE 415
Query: 1455 YEELTGKY--ELLEEEHVVTK--ARLTVEKEQAQGELLHVQKELSTALGEIKTLQE---K 1507
+ + KY E+++E R E E+AQ + + +L A+ EI+ LQE K
Sbjct: 416 NKRI-NKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDK 474
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+S+ + M+ + L +++ E+E AR N + E + +V+
Sbjct: 475 ANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVIS 534
Query: 1568 HH 1569
H
Sbjct: 535 QH 536
Score = 48.0 bits (109), Expect = 3e-04
Identities = 78/428 (18%), Positives = 171/428 (39%), Gaps = 30/428 (7%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
++L+ L++ +K + IA D+++ + ++ K +L+ +++ +R+++ +
Sbjct: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQ-SQFTRTKEELEAEKRDLIRTNERLSQELEYL 141
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK---ARLTVEKEQAQGELLHVQKEL 1494
E VK+L L EL K + L+ V K RL EKE + + EL
Sbjct: 142 TEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL 201
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
T E+ L + G E + ++ L+E++ G + L ++
Sbjct: 202 KTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM--NGLKTSNEHLQKHVEDLLT 259
Query: 1555 ELRAANDRRDVLEH--HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+L+ A +++ +E H++ + +K
Sbjct: 260 KLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAK--------SNELTRAVEELH 311
Query: 1613 XXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSM 1672
++++ +A KA I D E + M K + ++ R +E +N +L A ++
Sbjct: 312 KLLKEAGEANKA-IQDHLLEVEQSKDQME---KEMLEKIGRLEKELENANDLLSATKRKG 367
Query: 1673 AEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSE 1732
A I + ++ A + + + + K+ L +D+L +L ++N L
Sbjct: 368 A-ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
Query: 1733 KSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAW---HKERDEQQRLLQETS 1789
E + ++ + EYE + VA L+ ++E A + +++ + +++S
Sbjct: 427 VKEVEAKAPILKRQREEYER------AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
Query: 1790 TLARDLRQ 1797
L RD R+
Sbjct: 481 VLERDNRR 488
Score = 46.4 bits (105), Expect = 0.001
Identities = 147/897 (16%), Positives = 351/897 (39%), Gaps = 59/897 (6%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR--RLANIDTANKYTTGRSSE 318
L+ +N + Q+ +E L ++V L ++ + K ++ L+ L D + KY R +
Sbjct: 127 LIRTNERLSQE-LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQ 185
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQLRAKLLAA 377
+L N T N +L+ + L RE +E LE + + E + ++ +L ++
Sbjct: 186 EKELLHSQN--TWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFRED-------------QADEYSSLRREL 424
+T E L ED+ +L++ M++ F + AD+ + EL
Sbjct: 244 KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
Query: 425 EQTIKNCRVLSFKLKKTERKAD----QLEQEKAEHEKKLLEIVGGPD-GMQREN-RIKEL 478
+ ++ L + + + ++EQ K + EK++LE +G + ++ N +
Sbjct: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
Query: 479 EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQL 538
+++ A +E L A A +K L ++ V+ L + +
Sbjct: 364 KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL-YNAYVETQDQLLLEKLENKRINKY 422
Query: 539 LRDLQDSLEREADL----REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD----IH 590
L ++ +E +A + RE+ A++ A+ + Q + ++ + +
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL 650
E + IQ K + E ++ + + E + I H+ +
Sbjct: 483 ERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVS--- 539
Query: 651 RKTAARVEEDNESLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE 709
+ +++ N+ LL+ L+++ T+ R + + + +L ++ + E E
Sbjct: 540 YRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQH 599
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
L++ ++ + R + + L + S S+ + S + +
Sbjct: 600 QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPV 659
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
+ A E L+ ++ E+ + +++ + E++ E ++ T ++S++ S Q
Sbjct: 660 IESTEAIEAKAALK-QLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ KR ++++ R + SL N+KL +K + + N + A +
Sbjct: 719 DFASKR-YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVA 777
Query: 890 TTQLENELKE-ALAKIKELEMICQDEK--SEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
+ EN KE + K+ E+ + Q E +E++ + T +T ++
Sbjct: 778 EVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL 837
Query: 947 XXXXXXXXXXXQATLKSLKDDAQ------KSFKPRI--PKKPTDLTTKLQL--KKMVEDL 996
K L+++ + ++ ++ K+ D T L L K+++++
Sbjct: 838 SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNA 897
Query: 997 ECEIGEMYVVMKN----AGLSGKEMTAK--TKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ EI + + N + T K ++++D++ S+L + + + + K RL+T
Sbjct: 898 QKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKT 957
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ ++ A + ++ + + E N+ + K E E ++ ++ +
Sbjct: 958 STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE 1014
Score = 41.5 bits (93), Expect = 0.030
Identities = 80/454 (17%), Positives = 185/454 (40%), Gaps = 37/454 (8%)
Query: 272 QIEGLK--QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q+E L+ Q V++L + + +E D L + K T + E++K + +N +
Sbjct: 1218 QVESLRYRQRVELLERELQELE----DSLNAEREKVQVTAK-TMAQHEELMKKTETMNVV 1272
Query: 330 TTHNEDLRDEKKHLTQKIREIES-----ELETRPSTEAQTRQIEQLRAKLLAAETLCEE- 383
N+ LR+EK+ L Q ++++++ EL+ P EA ++ + L A + L EE
Sbjct: 1273 METNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA-ELSEKSGMLQAEKKLLEED 1331
Query: 384 ----------LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRV 433
L+ + +D E + + +E L+ E+ ++ +
Sbjct: 1332 VKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL-LEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ + +++ EK +K L +I+ + ++ ++K++ + E
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451
Query: 493 QRELAEANSKFTGSNPSL-MKVPQPETVKVS-RSSLTRGGSQEDPAQLLRDLQDSLEREA 550
Q ++ E +++ +G + + V + + +K + + T+ S E + L+ E EA
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 551 -DLREQLRNAEEETANCKQ-VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
+L+EQ + E + +Q + T ++Q+ +T ++ + ++K+ H A
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAKSKIAHLAG 1569
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAA------NNLRKTAARVEEDNE 662
K + + ++ + D+ ++ + LR+ R E +
Sbjct: 1570 VKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRD 1629
Query: 663 SLLLQLKKMATKARSRKLSPTPPANKLSIETAND 696
K+ + R L TP + + I + +D
Sbjct: 1630 EPQEPSNKVPEQQRQITLKTTPASGERGIASTSD 1663
>U69668-1|AAB48030.1| 2363|Homo sapiens Tpr protein.
Length = 2363
Score = 77.0 bits (181), Expect = 6e-13
Identities = 234/1292 (18%), Positives = 495/1292 (38%), Gaps = 113/1292 (8%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKE---KSDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
E QDQ+ K E + K + + KE K+ IL R+ + A K S ++ + +
Sbjct: 404 ETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMK 463
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAK--LLAAETLC 381
++ L + + L + R +E ++ + ++E+ R + E
Sbjct: 464 EIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQA-DEYSSLRRELEQTIKNCRVLSFKLKK 440
++ +E + + L Q N R A E R EQ + ++ +LK
Sbjct: 524 ADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK- 582
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE-LAEA 499
E +LEQ + + ++ ++V D + R+ + + ++++T VA+ L L +
Sbjct: 583 LESALTELEQLRKSRQHQM-QLV---DSIVRQRDMYRIL--LSQTTGVAIPLHASSLDDV 636
Query: 500 NSKFTGSNPSL---MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLEREADLREQ 555
+ T PS + P P V S ++ + + ++ + + + E E EQ
Sbjct: 637 SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ 696
Query: 556 LRNAEEETANCKQVNPP--TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
L +E+ + + N T LD ++ ++ S+ + +T +
Sbjct: 697 LEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQ 756
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMAT 673
E+ I+ T++ + + ++ + A NL+K ++ L Q + +
Sbjct: 757 EQI------INTMTQDLRGANEKLAVA---EIRAENLKKEKEMLKLSEVRLSQQRESLLA 807
Query: 674 KARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQ 733
+ R + L T N +I+ + E ET + ++++ L E E + L++K+E +
Sbjct: 808 EQRGQNLLLT---NLQTIQGILERSETETKQRLSSQIEKL----EHEISHLKKKLENEVE 860
Query: 734 DKEALKKQ--VKELTSKISSVTKTSAGSNT-----TARRSLTTNSNKLAEERVKVLEDEI 786
+ L + V+ L +K T+T+ NT A++ + T L+ V+V
Sbjct: 861 QRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKRHLSNMEVQVASQSS 920
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTL---IKSRSLDASDQQNV--DLKRQLQVIE 841
K + D + L ++L +++ L +K+ + + Q + L+ L +
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK 980
Query: 842 QEASVLRAKTQSLEADNEKLQT--ENKKLQLLKNAKSLRSDKALDLNT--------KKT- 890
Q +R + ++ + QT E K +++ K + L+ DK + + KKT
Sbjct: 981 QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL 1040
Query: 891 TQLENELKEALAKI-------KELEMICQDE---------KSEKK-------VRFTEATK 927
+ ++NE++EAL + ++ CQ++ K E++ V +A K
Sbjct: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAK 1100
Query: 928 KETDTLKS-KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTK 986
++ + S +Q + + LKD+ K + +
Sbjct: 1101 EQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLH 1160
Query: 987 LQLKKMVEDLECEIGEMYVVMKNAGLS--GK------EMTAKTKLEKEIDEIRSKLSKND 1038
Q++K+ + + + E N LS GK E+ + EKEI E R ++++ +
Sbjct: 1161 DQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVE 1220
Query: 1039 S-EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNR 1097
S + L+ E+ +L+D + E +K K A E + + E K
Sbjct: 1221 SLRYRQRVELLERELQELQD-SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKML 1279
Query: 1098 EAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN 1157
+ +L DL+ + + + ++ K + +N
Sbjct: 1280 REEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
Query: 1158 KLL--KEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVL 1215
+ L ++ T++ +++ +++ K + L
Sbjct: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
Query: 1216 ANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVH 1275
++ E + + +L A+ I + K T+ +++ + Y+ T E A +D
Sbjct: 1400 KEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI-TQVKKIGRRYK---TQYEELKAQQD-- 1453
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
K +E + Q++ D ++ S EM E++ + ++ N + L + E E+
Sbjct: 1454 -KVMETSA-QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
+ + QL+S+L++L + E K ++ +S +
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS--------K 1563
Query: 1396 IAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
IAH VK++ E LK + L+Q RIT LK +YE + +LE L +
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQER 1623
Query: 1455 YEELTGKYELLEEEHVVTKARLTVEKEQAQGE 1486
+ E + + + + ++T++ A GE
Sbjct: 1624 HLEQRDEPQEPSNKVPEQQRQITLKTTPASGE 1655
Score = 64.9 bits (151), Expect = 3e-09
Identities = 230/1234 (18%), Positives = 477/1234 (38%), Gaps = 104/1234 (8%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREI-ESELETRPSTEAQTRQIEQLRAKLLAAET 379
++ +K+ L E+ D +K + E EL T A +I + KL
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
E D+ K E + + + E +A R E E+ K LS KL+
Sbjct: 401 AYVETQDQLLLEKLENKRINKYLDEIVKEV-EAKAPILKRQREEYERAQKAVASLSVKLE 459
Query: 440 KTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ ++ +L+++ KA + +LE D + E ++K+L Q++ L ++ E A
Sbjct: 460 QAMKEIQRLQEDTDKANKQSSVLE----RDNRRMEIQVKDLSQQIR-----VLLMELEEA 510
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
N S + V +S+ ++ +E L + Q L +L E
Sbjct: 511 RGNHVIRDEEVSSADISSSSEV-ISQHLVSYRNIEE----LQQQNQRLLVALRELGETRE 565
Query: 558 NAEEETANCKQVNPPTFLDKQVMT-DNIVTCDIHESETVTNSIQNKMIH--------AAS 608
E+ET + K L+ + + + H+ + V + ++ + ++ +
Sbjct: 566 REEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVA 625
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPY-LSIFNHMAANNLRKTAARVEEDNESLLLQ 667
P D L+ T P + + A + +++E E+
Sbjct: 626 IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENY--- 682
Query: 668 LKKMATKARSRKLSPTPPANKLSIETAN--DNDEKETDEADPAEMKLLLELNEQEATVLR 725
KK KA + K+ KL + + + K + + D A + E+ + R
Sbjct: 683 -KK--EKAENEKIQ-NEQLEKLQEQVTDLRSQNTKISTQLDFASKRY--EMLQDNVEGYR 736
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT-ARRSLTTNSNKLAEERVKVLED 784
R++ L + + L ++ I+++T+ G+N A + + K +E +K+ E
Sbjct: 737 REITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEIRAENLKKEKEMLKLSEV 796
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
+ + R+ L+ ++R L L Q I RS + Q+ L Q++ +E E
Sbjct: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQG-----ILERSETETKQR---LSSQIEKLEHEI 848
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAK 903
S L+ K ++ E + T N +QLL + L ++ L LNTK+ + + E+
Sbjct: 849 SHLKKKLEN-EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKRH 907
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSK----QXXXXXXXXXXXXXXXXXXXXQA 959
+ +E+ + S++ + + K++ D L S+ + QA
Sbjct: 908 LSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQA 967
Query: 960 TLKSLK----------DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ SL+ ++ +K+ + R+ K+ + T+L+ KK++E +E E E+ +
Sbjct: 968 MVTSLEESLNKEKQVTEEVRKNIEVRL-KESAEFQTQLE-KKLME-VEKEKQELQDDKRR 1024
Query: 1010 AGLSGKEMTAKTK--LEKEIDEIRSKLSKNDSEFTNEK--NRLQTEIAKLK-DVNAKLEG 1064
A S ++ ++ K L +E++ L + + +NE+ R E AK+ + K E
Sbjct: 1025 AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYER 1084
Query: 1065 DKDVFANKYKALENENSNLSNQCKT---LTEEMKNREAQINKLSADL-KNATSLQTTMSD 1120
+ + A +AL+ +S L E + E+Q+ + A + L+ +S
Sbjct: 1085 ELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSK 1144
Query: 1121 CMXXXXXXXXXXXXXXXXXXXXXXQVDNYTK--IDQDKNKLLKEVGDKTKKIGDXXXXXX 1178
C+ +V K + N L E G ++I +
Sbjct: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
Query: 1179 XXXXXCK-RIE-KQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR-RLSIELTSEKDELQA 1235
+ R E Q+ + + R Q + A + +++ + ++ +EL
Sbjct: 1205 REKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMK 1264
Query: 1236 RFIKTESKFITLEAE--MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDE 1293
KTE+ + +E +R+ K E + +++ + ++ I L++A ++K
Sbjct: 1265 ---KTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEA-NAELSEKSGM 1320
Query: 1294 ATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLE 1353
+ +++E Q + + + + K +E + QL ++ +L+
Sbjct: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE-EYRKLLSEKEVHTKRIQQLTEEIGRLK 1379
Query: 1354 NXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLK 1413
+N + L DL R + + ++ KD+ DA++ ++
Sbjct: 1380 AEIARSNASLTNN-------QNLIQSLKEDLNKVRTEKETIQ----KDL---DAKIIDIQ 1425
Query: 1414 GKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK 1473
K+K + Q G + T+ ++ + K +E S E+ E+ E + + +
Sbjct: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
Query: 1474 ARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
A + ++Q E ++QK LS E + LQE+
Sbjct: 1486 AETKSKSLESQVE--NLQKTLSEKETEARNLQEQ 1517
Score = 58.8 bits (136), Expect = 2e-07
Identities = 208/1204 (17%), Positives = 460/1204 (38%), Gaps = 105/1204 (8%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAKLLAAETLC 381
Q +++ L +E + E + Q+ EIE L ++ +TR+ + LR +L
Sbjct: 33 QSEIDGLKGRHEKFKVESE---QQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQL 89
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+ L ++N++++ +D +E+ E L R E+ + L+ +K+
Sbjct: 90 KALTEKNKELEIA-QDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRL 148
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRI---KEL--EQEVARSTEVALRLQRE 495
K + K E + KL E+ ++ RE R+ KEL Q +TE+ +
Sbjct: 149 NEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL 208
Query: 496 LAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
LA K G+ +K + + +VSR G + L + ++D L + + +E
Sbjct: 209 LALGREK--GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE 614
Q + EE+ N L+ + N+ +SE +N + + KE
Sbjct: 267 QQASMEEKFHN--------ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKL--LKE 316
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA-- 672
++ D E Q + + + +E N+ L +K A
Sbjct: 317 AGEANKAIQDHLLEVEQSKDQM------EKEMLEKIGRLEKELENANDLLSATKRKGAIL 370
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL-NEQEATVLRRKVEEL 731
++ +SPT A ++ E + + LL +L N++ L V+E+
Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
E LK+Q +E +V SL+ + +E ++ L+++ D+ K
Sbjct: 431 EAKAPILKRQREEYERAQKAVA------------SLSVKLEQAMKE-IQRLQEDTDKANK 477
Query: 792 KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+ ERD R+ ++ ++ + L+ + D + I + V+
Sbjct: 478 QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHL 537
Query: 852 QSLEADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
S + E+LQ +N++L + L+ R + + + K T+L+ +L+ AL ++++L
Sbjct: 538 VSYR-NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLR-- 594
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ + +++ ++ ++ D + +T K + +
Sbjct: 595 ---KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK--RPSTSQ 649
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK--NAGLSGKEMTAKTKLEKEID 1028
+ P + T ++ K ++ L+ EI E Y K N + +++ KL++++
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQ-EIFENYKKEKAENEKIQNEQL---EKLQEQVT 705
Query: 1029 EIRSKLSK--NDSEFTNEKNRL--------QTEIAKLKDVNAKL----EGDKDVFANKYK 1074
++RS+ +K +F +++ + + EI L + N KL + + + +
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXX 1134
L N L+ + E +K +E ++ KLS +++ + ++ +++
Sbjct: 766 DLRGANEKLA-VAEIRAENLK-KEKEMLKLS-EVRLSQQRESLLAE---QRGQNLLLTNL 819
Query: 1135 XXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK----RIEKQ 1190
+ + ++ KL E+ KK+ + ++Q
Sbjct: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI-TLEA 1249
L T + + L + +++ S+ + + + + + L +
Sbjct: 880 LDTETNLHLNTKELLKNAQKEIATLKRHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939
Query: 1250 EMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
++R E ++ L+ + +++Q + A+ + + ++ E V
Sbjct: 940 QLRQT----EEQVNDLKERLKTSTSNVEQYQ-AMVTSLEESLNKEKQVTEEVRKNIEVRL 994
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
Q E +++ EK E + + + ++ L++L+
Sbjct: 995 KESAEFQTQLEKKLMEVEKEKQELQDDKRR-AIESMEQQLSELKKTLSSVQNEVQEALQR 1053
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
+S + ++ D Q + K + +++++ A++ L+ EQ S +
Sbjct: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA---AKEQVS-----K 1105
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLH 1489
+ ++Q EET +K E L KA +EE + +L++E V+K E + Q LLH
Sbjct: 1106 MASVRQHLEETTQKAESQLLECKASWEE---RERMLKDE--VSKCVCRCEDLEKQNRLLH 1160
Query: 1490 VQKE 1493
Q E
Sbjct: 1161 DQIE 1164
Score = 58.4 bits (135), Expect = 2e-07
Identities = 254/1549 (16%), Positives = 577/1549 (37%), Gaps = 104/1549 (6%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR--RLANIDTANKYTTGRSSE 318
L+ +N + Q+ +E L ++V L ++ + K ++ L+ L D + KY R +
Sbjct: 127 LIRTNERLSQE-LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQ 185
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQLRAKLLAA 377
+L N T N +L+ + L RE +E LE + + E + ++ +L ++
Sbjct: 186 EKELLHSQN--TWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFRED-------------QADEYSSLRREL 424
+T E L ED+ +L++ M++ F + AD+ + EL
Sbjct: 244 KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
Query: 425 EQTIKNCRVLSFKLKKTERKAD----QLEQEKAEHEKKLLEIVGGPD-GMQREN-RIKEL 478
+ ++ L + + + ++EQ K + EK++LE +G + ++ N +
Sbjct: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
Query: 479 EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQL 538
+++ A +E L A A +K L ++ V+ L + +
Sbjct: 364 KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL-YNAYVETQDQLLLEKLENKRINKY 422
Query: 539 LRDLQDSLEREADL----REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD----IH 590
L ++ +E +A + RE+ A++ A+ + Q + ++ + +
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL 650
E + IQ K + E ++ + + E + I H+ +
Sbjct: 483 ERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVS--- 539
Query: 651 RKTAARVEEDNESLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE 709
+ +++ N+ LL+ L+++ T+ R + + + +L ++ + E E
Sbjct: 540 YRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQH 599
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
L++ ++ + R + + L + S S+ + S + +
Sbjct: 600 QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPV 659
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
+ A E L+ ++ E+ + +++ + E++ E ++ T ++S++ S Q
Sbjct: 660 IESTEAIEAKAALK-QLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ KR ++++ R + SL N+KL +K + + N + DL
Sbjct: 719 DFASKR-YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT------QDLRGAN 771
Query: 890 TTQLENELK-EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
E++ E L K KE+ + + S+++ + + L + Q
Sbjct: 772 EKLAVAEIRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSET 831
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
L+ +K + + ++ T LT L ++ + + + E + +
Sbjct: 832 ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHT-LTRNLDVQLLDTKRQLDT-ETNLHLN 889
Query: 1009 NAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
L L++ + + +++ S+ T + E + D+ ++L ++
Sbjct: 890 TKELLKNAQKEIATLKRHLSNMEVQVASQSSQRTGKGQPSNKE--DVDDLVSQLRQTEEQ 947
Query: 1069 FANKYKALENENSNLSNQCKTLT--EEMKNREAQINK-----LSADLKNATSLQTTMSDC 1121
+ + L+ SN+ +T EE N+E Q+ + + LK + QT +
Sbjct: 948 VNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKK 1007
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+ Q +++ + + + EV + ++
Sbjct: 1008 LMEVEKEKQELQDDKRRAIESMEQ--QLSELKKTLSSVQNEVQEALQRASTALSNEQQAR 1065
Query: 1182 XXCKR-----IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQAR 1236
C+ +E Q ++ + + V R +E T++K E Q
Sbjct: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ-- 1123
Query: 1237 FIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS 1296
++ ++ + E ++D + + LE I++L D + + + +
Sbjct: 1124 LLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGV-QGPL 1182
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXX 1356
V + E + E A+ + E + ES + + L+ +L +L++
Sbjct: 1183 NVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSL 1242
Query: 1357 XXXXXXXXXXXXXSSYWENKAKELDT--DLQSERKKLDRMRIAHDKDVKNKDAELATLK- 1413
+ E K+ +T + K L + ++D++ A++ L+
Sbjct: 1243 NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL 1302
Query: 1414 GKLKILEQNSGAGAK--RITELKQEYEETVKKLE-HSLALEKAEYEELTGKY-ELLEEEH 1469
L + E N+ K + K+ EE VK+ + + L + + T +Y +LL E+
Sbjct: 1303 DILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE 1362
Query: 1470 VVTK--ARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
V TK +LT E + + E+ L+ I++L+E L T + ++ I
Sbjct: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
Query: 1528 SLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDY 1587
+QE++ + ++ R + EL+A D+ V+E
Sbjct: 1423 DIQEKV---KTITQVKKIGRRYKTQYEELKAQQDK--VMETSAQSSGDHQEQHVSVQEMQ 1477
Query: 1588 ERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSL 1647
E + + E+ +AR + + + + +++ +R +L+
Sbjct: 1478 ELKETLNQAETKSKSLESQVENLQKTLSEKETEAR--NLQEQTVQLQSELSRLRQDLQDR 1535
Query: 1648 HNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDE-EEYRNKVALLEQ 1706
Q + R++ + E +K++ K+ K A + T E EE + + L+Q
Sbjct: 1536 TTQEEQLRQQ---ITEKEEKTRKAIVAAKS--KIAHLAGVKDQLTKENEELKQRNGALDQ 1590
Query: 1707 QVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERL 1755
Q +DE L+ + + KS E R++ ++ L E++E L
Sbjct: 1591 Q----KDE----------LDVRITALKSQYEGRISRLERELREHQERHL 1625
Score = 48.0 bits (109), Expect = 3e-04
Identities = 78/428 (18%), Positives = 171/428 (39%), Gaps = 30/428 (7%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
++L+ L++ +K + IA D+++ + ++ K +L+ +++ +R+++ +
Sbjct: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQ-SQFTRTKEELEAEKRDLIRTNERLSQELEYL 141
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK---ARLTVEKEQAQGELLHVQKEL 1494
E VK+L L EL K + L+ V K RL EKE + + EL
Sbjct: 142 TEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL 201
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
T E+ L + G E + ++ L+E++ G + L ++
Sbjct: 202 KTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM--NGLKTSNEHLQKHVEDLLT 259
Query: 1555 ELRAANDRRDVLEH--HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+L+ A +++ +E H++ + +K
Sbjct: 260 KLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAK--------SNELTRAVEELH 311
Query: 1613 XXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSM 1672
++++ +A KA I D E + M K + ++ R +E +N +L A ++
Sbjct: 312 KLLKEAGEANKA-IQDHLLEVEQSKDQME---KEMLEKIGRLEKELENANDLLSATKRKG 367
Query: 1673 AEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSE 1732
A I + ++ A + + + + K+ L +D+L +L ++N L
Sbjct: 368 A-ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
Query: 1733 KSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAW---HKERDEQQRLLQETS 1789
E + ++ + EYE + VA L+ ++E A + +++ + +++S
Sbjct: 427 VKEVEAKAPILKRQREEYER------AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
Query: 1790 TLARDLRQ 1797
L RD R+
Sbjct: 481 VLERDNRR 488
Score = 41.5 bits (93), Expect = 0.030
Identities = 82/454 (18%), Positives = 185/454 (40%), Gaps = 37/454 (8%)
Query: 272 QIEGLK--QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q+E L+ Q V++L ER +E D L + K T + E++K + +N +
Sbjct: 1218 QVESLRYRQRVELL----ERELQELQDSLNAEREKVQVTAK-TMAQHEELMKKTETMNVV 1272
Query: 330 TTHNEDLRDEKKHLTQKIREIES-----ELETRPSTEAQTRQIEQLRAKLLAAETLCEE- 383
N+ LR+EK+ L Q ++++++ EL+ P EA ++ + L A + L EE
Sbjct: 1273 METNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA-ELSEKSGMLQAEKKLLEED 1331
Query: 384 ----------LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRV 433
L+ + +D E + + +E L+ E+ ++ +
Sbjct: 1332 VKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL-LEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ + +++ EK +K L +I+ + ++ ++K++ + E
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451
Query: 493 QRELAEANSKFTGSNPSL-MKVPQPETVKVS-RSSLTRGGSQEDPAQLLRDLQDSLEREA 550
Q ++ E +++ +G + + V + + +K + + T+ S E + L+ E EA
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 551 -DLREQLRNAEEETANCKQ-VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
+L+EQ + E + +Q + T ++Q+ +T ++ + ++K+ H A
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAKSKIAHLAG 1569
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAA------NNLRKTAARVEEDNE 662
K + + ++ + D+ ++ + LR+ R E +
Sbjct: 1570 VKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRD 1629
Query: 663 SLLLQLKKMATKARSRKLSPTPPANKLSIETAND 696
K+ + R L TP + + I + +D
Sbjct: 1630 EPQEPSNKVPEQQRQITLKTTPASGERGIASTSD 1663
>BX284668-2|CAH70055.1| 2017|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 2017
Score = 77.0 bits (181), Expect = 6e-13
Identities = 239/1266 (18%), Positives = 483/1266 (38%), Gaps = 89/1266 (7%)
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESEL------ETRPSTEAQTRQI--EQLRAKLLAAET 379
+L + +L ++ T+ +++ES L + R ++ AQ + EQL A +
Sbjct: 193 QLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 252
Query: 380 LCEELMDENEDM---KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
L E++ D +KEL +++F ++E+S L Q + R++S
Sbjct: 253 LSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSE 312
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEI-VGGPDGMQ-RENRIKE-LEQEVARSTEVALRLQ 493
TER QL E A + + E +G G++ E+R + LE++ ++ +L+
Sbjct: 313 VKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLR 372
Query: 494 -RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE-DPAQLLRDLQDSLEREAD 551
+ L E + L K V ++ R Q + Q+ +DL + LE
Sbjct: 373 DKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALES 432
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAAST 609
LR Q + A E L + V++D+ + SE ++ + + T
Sbjct: 433 LRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN---HMAANNLRKTAARVEEDNESLLL 666
PS +S SP + D L++ + H ++ R E ++ LL
Sbjct: 493 PSPPRRS-SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA-SQDLLG 550
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
L+K + + S + + +L +T E + + ++ EL +E + L
Sbjct: 551 TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAH 610
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
++ +Q E L+++ ++L + A+ L ++L EE+ ++D
Sbjct: 611 SLQVAQQQAEELRQEREKLQA---------------AQEELRRQRDRLEEEQEDAVQDGA 655
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL-----DASDQQNVDLKRQLQVIE 841
VR++L R E+L + S+ K+ + ++ S D + ++ L E
Sbjct: 656 -RVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
L L A+ LQ KL L +SL DK LDLN + QLE E
Sbjct: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALN--ESLAQDK-LDLN-RLVAQLEEEKSALQ 770
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
+ ++ E + E++ R E ++ + + +
Sbjct: 771 GRQRQAEQEATVAREEQE-RLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHER 829
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK-NAGLSGKEMTAK 1020
L++ + + ++ + + ++ VE LE E + K +AGL+ ++ A
Sbjct: 830 SQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA-VQLVAA 888
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENEN 1080
+ + + E ++L +Q ++A+L+ +LE + + L E
Sbjct: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948
Query: 1081 SNLSNQCKTLTEEMK-NREAQINKL-SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
+ L Q E+ ++E KL A+ + SL+ +
Sbjct: 949 AGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRE 1008
Query: 1139 XXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
Q+ + ++ +++ +LL + + +++ + + + S ++ +
Sbjct: 1009 LEAERAQLQS--QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE--SEKQQAL 1064
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + + ++ +S+E+ +K + Q+R + S L +E+RDL+A
Sbjct: 1065 SLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA-- 1122
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
E AA +++L++ R + D E E+R +
Sbjct: 1123 -----QREEAAAAHAQEVRRLQEQARDLGKQR-DSCLREAE--ELRTQLRLLEDARDGLR 1174
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
EL A+ KL +++ + E +L+ L E S+ + +++
Sbjct: 1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLG--EGAKEREALRRSNEELRSAVKKAESE 1232
Query: 1379 ELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYE 1438
+ L +E K+ + + K+A L+ L+ +E++ + + EL+++
Sbjct: 1233 RISLKLANEDKEQKLALLEEARTAVGKEA--GELRTGLQEVERSRLEARRELQELRRQ-- 1288
Query: 1439 ETVKKLEHSLALEKAEYEELTGKYELLE-------EEHVVTKARL---TVEKEQAQGELL 1488
+K L+ E EL G+ L E E + + RL E + EL
Sbjct: 1289 --MKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQ 1346
Query: 1489 HVQKELSTALGEIKTLQEK-LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNA 1547
Q++L GE +T + + LG+ A TEK ++ ++ L+ +L E A L
Sbjct: 1347 VAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA-RGLELKLEAA--RAEAAELGL 1403
Query: 1548 RLDQRE 1553
RL E
Sbjct: 1404 RLSAAE 1409
Score = 68.5 bits (160), Expect = 2e-10
Identities = 136/703 (19%), Positives = 276/703 (39%), Gaps = 54/703 (7%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTG 314
+ +E + + E L+ + LR++ +R+E+E+ D + R L + G
Sbjct: 614 VAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEG 673
Query: 315 RSS----EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQ 369
+ S E++++++ ++ T + L+ EK + + + + E+ +E S +
Sbjct: 674 KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEAS 733
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
L+ L L E L + D+ + + L +Q R+ QA++ +++ RE ++ ++
Sbjct: 734 LQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQG--RQRQAEQEATVAREEQERLE 791
Query: 430 NCRV--------LSFKLKKTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELE 479
R+ L L+ E+ + LEQ+ HE+ L+ Q R +ELE
Sbjct: 792 ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 851
Query: 480 Q---EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA 536
Q E R E R RE + G L+ + G + + A
Sbjct: 852 QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER------------EGRTLSEEA 899
Query: 537 QLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETV 595
LR +++LE +++ QL E + L K+ +T + T
Sbjct: 900 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQ 959
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
+ +K + A ++ ++ + EE + + + A + +
Sbjct: 960 EKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER-AQLQS 1018
Query: 656 RVEEDNESLL--LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+++ + E LL L+ +K L L E+ + A + L
Sbjct: 1019 QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 1078
Query: 714 LELNEQEATV---LRRKVEELEQDKEALKKQVKELTSKISSV---TKTSAGSNTTARRSL 767
+ AT+ + R+ + + +E + V LTS++ + + +A ++ R L
Sbjct: 1079 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1138
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD 827
+ L ++R L E +E+R +L E + L EL AQ+K + + R +
Sbjct: 1139 QEQARDLGKQRDSCLR-EAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR--EVQR 1195
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL---KNAKSLRSDKALD 884
Q+ +L+R L +E LR + L + +K ++E L+L K K ++A
Sbjct: 1196 QEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART 1255
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
K+ +L L+E E Q+ + + K+ +E T+
Sbjct: 1256 AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTR 1298
Score = 64.5 bits (150), Expect = 4e-09
Identities = 130/638 (20%), Positives = 264/638 (41%), Gaps = 50/638 (7%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKI 347
E + ++K D L R +A ++ GR + + E E+LR E++ Q +
Sbjct: 746 ESLAQDKLD-LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGL 804
Query: 348 R-EIESELETRPSTEAQTRQIEQLRAKLLAA-ETLCEELMDENEDMKKELRDLXXXXXXM 405
+ + + + E Q + R++L L +L +++++ R+ +
Sbjct: 805 EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEAL 864
Query: 406 QDNFREDQA--DEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
+ RE +A E++ L +L + R LS + + + + LE E +++L ++
Sbjct: 865 ERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLE 924
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ ++ E + L +E LR Q+ +A K+ Q E +
Sbjct: 925 ARREQLEAEGQALLLAKETLTGELAGLR-QQIIATQEKASLDKELMAQKLVQAEREAQAS 983
Query: 524 SSLTRGGSQEDPAQLLRDLQDS---LERE-ADLREQLRNAEEET-----ANCKQVNPPTF 574
R +ED +L R+ + + LE E A L+ QL+ +EE A ++++
Sbjct: 984 LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIA 1043
Query: 575 LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHF 634
+Q + ++ + + + ++ K + ++ + L +++ + Q
Sbjct: 1044 ALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQ 1103
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS---RKLSPTPPANKLS- 690
+ ++ + + LR A+ EE + +++++ +AR ++ S A +L
Sbjct: 1104 EQDRSTV--NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRT 1161
Query: 691 ----IETANDNDEKETDEADPA--EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKE 744
+E A D +E EA E + E+ QEA LRR + E +++EAL++ +E
Sbjct: 1162 QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEE 1221
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDEIDEVRKKLIEKERDCER 802
L S + K + + + + KLA EE + E E+R L E ER R
Sbjct: 1222 LRSAV----KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER--SR 1275
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV-LRAKTQSLEADNEKL 861
L A L + + R + D +N L R+L ++ ++ RA+ +S +
Sbjct: 1276 LEARRELQELR-------RQMKMLDSENTRLGRELAELQGRLALGERAEKES------RR 1322
Query: 862 QTENKKLQLLKNAKSLR-SDKALDLNTKKTTQLENELK 898
+T + +LLK SL + L + +K + E E +
Sbjct: 1323 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1360
Score = 60.5 bits (140), Expect = 6e-08
Identities = 147/821 (17%), Positives = 320/821 (38%), Gaps = 68/821 (8%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E L++ + LR ++ E E+ + +LAN D K + + ++ EL T
Sbjct: 1213 EALRRSNEELRSAVKKAESERISL---KLANEDKEQKLALLEEARTA-VGKEAGELRTGL 1268
Query: 334 EDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELMDENEDMK 392
+++ + ++++E+ +++ S + R++ +L+ +L E +E E ++
Sbjct: 1269 QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR 1328
Query: 393 KELRDLXXXXXXMQDNFR------EDQADEYSSLRRELEQTIKNCRVLSFK----LKKTE 442
+ L M+ + ++Q E+ + R L +++ R + + E
Sbjct: 1329 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE 1388
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR--LQRELAEAN 500
K + E AE +L G G++ E E+++ A + LR L+R L
Sbjct: 1389 LKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGR 1448
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTR--------GGSQEDPAQLLRDLQDSLEREADL 552
+ P + + S L G P L+ EA +
Sbjct: 1449 APSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA-V 1507
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
R LR +E + ++ D+ + + + E E +S ++ A +
Sbjct: 1508 RGALREFLQELRSAQRER-----DELRTQTSALNRQLAEMEAERDSATSR---ARQLQKA 1559
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
+S+ S+D Q L S+ + R T +V SL Q +
Sbjct: 1560 VAESEEARRSVDGRLSGVQAELALQEESV--RRSERERRATLDQVATLERSL--QATESE 1615
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV--EE 730
+A K+S AN+ +E ++ D ++ +KL L+ E + R ++ +
Sbjct: 1616 LRASQEKISKMK-ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
E +AL+ +V L +++ ++ AG+ L K+ EE L D++ +
Sbjct: 1675 REAQAQALQDRVDSLQRQVAD-SEVKAGTLQLTVERLNGALAKV-EESEGALRDKVRGLT 1732
Query: 791 KKLIEKERDC-----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ L + + LH + +L + + LDA+ Q + ++Q + ++
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
LR + LE ++++ E + QL + + + +A LNT + Q E L + ++
Sbjct: 1793 TLRGEVADLEL--QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQE--RLG 1848
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
L+ ++EK+ A + E D + ++ + L+S +
Sbjct: 1849 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVE--------------REKLRSHE 1894
Query: 966 DDAQKSF-KPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
D + S K R+ + T +L + ++ ++ LE ++ + A L + +L
Sbjct: 1895 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL 1954
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
++E++ +RS ++ + + + + L++ + L+G
Sbjct: 1955 QQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1995
Score = 55.6 bits (128), Expect = 2e-06
Identities = 119/631 (18%), Positives = 233/631 (36%), Gaps = 49/631 (7%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTES-- 1242
+ +E+QL +D+ + L + + LS E ++ LQ + E
Sbjct: 564 RALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELR 623
Query: 1243 -KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMV 1301
+ L+A +L+ + E + ++LE + RQ + + E+V
Sbjct: 624 QEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELV 683
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXX 1361
E+R Q E L K EA +L M +L+++ A L++
Sbjct: 684 EVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL----- 738
Query: 1362 XXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQ 1421
+K L+ L ++ L+R+ V + E + L+G+ + EQ
Sbjct: 739 -------------SKLSALNESLAQDKLDLNRL-------VAQLEEEKSALQGRQRQAEQ 778
Query: 1422 NSGAG---AKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
+ +R+ EL+ E E + LE SL + + E L + L E + +L
Sbjct: 779 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838
Query: 1479 EKEQAQGELLHVQKELSTALGEIKTLQ------EKLGTESAAWNTEKTEMQNSIASLQER 1532
Q G +++ A +++ L+ E L E A + + +L E
Sbjct: 839 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
Query: 1533 LCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDY-ERVS 1591
+E+ L L + +R+L RR+ LE +++
Sbjct: 899 --ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQII 956
Query: 1592 KIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQV 1651
Q + S + ++A + R + + EL++ Q+
Sbjct: 957 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL 1016
Query: 1652 -SRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
S+ +RE++ LEA ++ ++E + + R+ E E + ++L E +
Sbjct: 1017 QSQLQREQEELLARLEAEKEELSE---EIAALQQERDEGLLLAESEKQQALSLKESEKTA 1073
Query: 1711 LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGL-AT 1768
L ++L +R + ++ E+ +K A+ R + +S +N E R L + R A A
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1133
Query: 1769 RMELAWHKERD---EQQRLLQETSTLARDLR 1796
+ + RD ++ L+E L LR
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLR 1164
Score = 50.0 bits (114), Expect = 8e-05
Identities = 173/830 (20%), Positives = 320/830 (38%), Gaps = 72/830 (8%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEA--QTRQIEQLRAKLLAAET 379
L Q EL + +++ L+ +R ES E +A Q + EQLR K+L +
Sbjct: 321 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD 380
Query: 380 LCEELMD---ENEDMKKELRDLXXXXXXMQ-DNFREDQADEYSSLRRELEQTIKNCRVLS 435
L ++ M + D+ + +L ++ N +DQ ++ L +LE +++ R+
Sbjct: 381 LAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNK--DLTEKLE-ALESLRLQE 437
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
+TE + L+Q + + +L G+Q E + + + L QR
Sbjct: 438 QAALETE-DGEGLQQTLRDLAQAVLS--DSESGVQLSG--SERTADASNGSLRGLSGQRT 492
Query: 496 LAEANSKFTGSNPSLMKVPQP-----ETVKVSRSSL---------TRG---GSQEDPAQL 538
+ G S + P P T+ + S+L RG SQ+ L
Sbjct: 493 PSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTL 552
Query: 539 LRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
+ L DS L EQL+ ++T Q + + Q + E + +S
Sbjct: 553 RKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS-REKSNLAHS 611
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
+Q A +EK + + + + + + ++ + + + R
Sbjct: 612 LQVAQQQAEELRQEREKLQAAQEELRRQRDRLE---EEQEDAVQDGARVRRELERSHRQL 668
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
E E L K + R T + L E A + EA E++L +
Sbjct: 669 EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
Query: 719 QEATVLRRKVEELEQDKEAL---KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E L+ + +L E+L K + L +++ G A + T +
Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE-- 786
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
+ER++ L E + R+ L R E+ A+ +L Q+ P TL RS +Q L R
Sbjct: 787 QERLEELRLEQEVARQGLEGSLRVAEQ--AQEALEQQLP-TLRHERS--QLQEQLAQLSR 841
Query: 836 QLQVIEQEASVLRAKTQ-SLEA------DNEKLQTENKKL--QLLKNAKSLR--SDKALD 884
QL EQE R + Q +EA + E L E+ L QL+ + R S++A
Sbjct: 842 QLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 901
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
L +K LE L E ++ +LE + ++E + KET T +
Sbjct: 902 LRLEKEA-LEGSLFEVQRQLAQLEARREQLEAEGQALL---LAKETLTGELAGLRQQIIA 957
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
Q +++ + +AQ S + + DL +LQ +K E E E
Sbjct: 958 TQEKASLDKELMAQKLVQA-EREAQASLREQRAAHEEDL-QRLQREKEAAWRELE-AERA 1014
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ +E+ A+ + EKE E+ +++ E ++ L E K + ++ K E
Sbjct: 1015 QLQSQLQREQEELLARLEAEKE--ELSEEIAALQQE--RDEGLLLAESEKQQALSLK-ES 1069
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ----INKLSADLKN 1110
+K + K + + +S + + + ++R+ Q +N L+++L++
Sbjct: 1070 EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRD 1119
Score = 48.0 bits (109), Expect = 3e-04
Identities = 102/531 (19%), Positives = 221/531 (41%), Gaps = 50/531 (9%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
Q++ ++LR + L +++ E+E+E R S ++ RQ+++ A+ +E
Sbjct: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAE---RDSATSRARQLQKAVAE---SEEARRS 1569
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ ++ EL L + R D+ ++L R L+ T R K+ K +
Sbjct: 1570 VDGRLSGVQAELA-LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1628
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+LE +K ++L E++ + ++ E + + LE E+ RS L L A+A +
Sbjct: 1629 NETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRS---RLGLSDREAQAQA 1681
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
SL + +V+ S + G Q +L L E E LR+++R E
Sbjct: 1682 -LQDRVDSLQR-------QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1733
Query: 562 ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + DK + +T H+ + + + + AA S+ + S L
Sbjct: 1734 ALAQ-SSASLNSTRDKNLHLQKALTACEHDRQ-----VLQERLDAARQALSEARKQSSSL 1787
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
T + DL + LR+ + +E + L ++K+ + R +
Sbjct: 1788 GEQVQTLRGEV-ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ-- 1844
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
S++ A E E E + + ++L E++ LRR ++++E++K +
Sbjct: 1845 ----ERLGSLQRALAQLEAEKREVERSALRL-----EKDRVALRRTLDKVEREKLRSHED 1895
Query: 742 VKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE 801
L+++ + +T G+ + + E +V VLE + +E + +
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAEA--QRQIQQLEAQVVVLEQSHSPAQ---LEVDAQQQ 1950
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
+L + + + + R+L+A ++ + +++++ +E++ S L+ + Q
Sbjct: 1951 QLELQQEVERLRSAQAQTERTLEARERAH---RQRVRGLEEQVSTLKGQLQ 1998
Score = 46.4 bits (105), Expect = 0.001
Identities = 96/425 (22%), Positives = 168/425 (39%), Gaps = 44/425 (10%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSA 757
+ DP ++ L QE +R+ +EL AL +Q+ E+ ++ S T + +
Sbjct: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 1560
Query: 758 GSNTTARRSLTTNSN------KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ ARRS+ + L EE V+ E E ++ ER + +EL +Q
Sbjct: 1561 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1620
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK----LQTENKK 867
+K + + + D++ LK L E L + +SLE + ++ L +
Sbjct: 1621 EKISKMKANETKLEGDKRR--LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ 1678
Query: 868 LQLLKNAKSLRSDKALDLNTKK-TTQLENE-LKEALAKIKELEMICQDEKSEKKVR-FTE 924
Q L++ + D K T QL E L ALAK++E E +D KVR TE
Sbjct: 1679 AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD-----KVRGLTE 1733
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
A + + +L S + Q L DA + K+ + L
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL-----DAARQALSEARKQSSSLG 1788
Query: 985 TKLQ-LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
++Q L+ V DLE ++ G+ + L ++ E + + +
Sbjct: 1789 EQVQTLRGEVADLE---------LQRVEAEGQLQQLREVL-RQRQEGEAAALNTVQKLQD 1838
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC-KTLTEEMKNREAQIN 1102
E+ LQ + L+ A+LE +K LE + L K E++++ E +
Sbjct: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV- 1897
Query: 1103 KLSAD 1107
+LSA+
Sbjct: 1898 RLSAE 1902
Score = 42.3 bits (95), Expect = 0.017
Identities = 82/412 (19%), Positives = 171/412 (41%), Gaps = 29/412 (7%)
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
D++ + L+ TE+E A++ +++++K++ KLE + E + +
Sbjct: 1600 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1659
Query: 1379 ELDTDLQSERKKL-DR---MRIAHDK--DVKNKDAELATLKGKLKI-LEQNSGAGAKRIT 1431
L+ +LQ R L DR + D+ ++ + A+ G L++ +E+ +GA AK +
Sbjct: 1660 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAK-VE 1718
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK--ARLTVEKEQAQGELLH 1489
E + + V+ L +LA A K L++ + ++ E+ A + L
Sbjct: 1719 ESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALS 1778
Query: 1490 VQKELSTALGE-IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR 1548
++ S++LGE ++TL+ E A ++ E + + L+E L E E A LN
Sbjct: 1779 EARKQSSSLGEQVQTLR----GEVADLELQRVEAEGQLQQLREVL-RQRQEGEAAALNT- 1832
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVS-KIQRXXXXXXXXXXXX 1607
++ D R +L+ + ER + ++++
Sbjct: 1833 -------VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKV 1885
Query: 1608 XXXXXXXIEQSEK--ARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQML 1665
E + + A K + T T E ++ + +++ L QV + + +
Sbjct: 1886 EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEV 1945
Query: 1666 EAAQKSMAEIKNGD--KSARIHRNSISSTDEEEYRNKVALLEQQVACLEDEL 1715
+A Q+ + + + +SA+ E +R +V LE+QV+ L+ +L
Sbjct: 1946 DAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
Score = 33.9 bits (74), Expect = 6.0
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 18/174 (10%)
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSIS---ST 1692
+ + +R + +L+ Q++ ERD+ QK++AE + +S + + +
Sbjct: 1524 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 1583
Query: 1693 DEEEY----RNKVALLEQQVACLEDEL--CESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
EE R + A L+ QVA LE L ES L AS+ E +S+ + E +L + R
Sbjct: 1584 QEESVRRSERERRATLD-QVATLERSLQATESELRASQ---EKISKMKANETKLEGDKRR 1639
Query: 1747 LNEY---EEERL--LSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
L E E R L R + G R L + Q L +L R +
Sbjct: 1640 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1693
>AL596220-1|CAI13119.1| 2363|Homo sapiens translocated promoter region
(to activated MET oncogene) protein.
Length = 2363
Score = 77.0 bits (181), Expect = 6e-13
Identities = 234/1292 (18%), Positives = 495/1292 (38%), Gaps = 113/1292 (8%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKE---KSDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
E QDQ+ K E + K + + KE K+ IL R+ + A K S ++ + +
Sbjct: 404 ETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMK 463
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAK--LLAAETLC 381
++ L + + L + R +E ++ + ++E+ R + E
Sbjct: 464 EIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQA-DEYSSLRRELEQTIKNCRVLSFKLKK 440
++ +E + + L Q N R A E R EQ + ++ +LK
Sbjct: 524 ADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK- 582
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE-LAEA 499
E +LEQ + + ++ ++V D + R+ + + ++++T VA+ L L +
Sbjct: 583 LESALTELEQLRKSRQHQM-QLV---DSIVRQRDMYRIL--LSQTTGVAIPLHASSLDDV 636
Query: 500 NSKFTGSNPSL---MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLEREADLREQ 555
+ T PS + P P V S ++ + + ++ + + + E E EQ
Sbjct: 637 SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ 696
Query: 556 LRNAEEETANCKQVNPP--TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
L +E+ + + N T LD ++ ++ S+ + +T +
Sbjct: 697 LEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQ 756
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMAT 673
E+ I+ T++ + + ++ + A NL+K ++ L Q + +
Sbjct: 757 EQI------INTMTQDLRGANEKLAVA---EVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
Query: 674 KARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQ 733
+ R + L T N +I+ + E ET + ++++ L E E + L++K+E +
Sbjct: 808 EQRGQNLLLT---NLQTIQGILERSETETKQRLSSQIEKL----EHEISHLKKKLENEVE 860
Query: 734 DKEALKKQ--VKELTSKISSVTKTSAGSNT-----TARRSLTTNSNKLAEERVKVLEDEI 786
+ L + V+ L +K T+T+ NT A++ + T L+ V+V
Sbjct: 861 QRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSS 920
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTL---IKSRSLDASDQQNV--DLKRQLQVIE 841
K + D + L ++L +++ L +K+ + + Q + L+ L +
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK 980
Query: 842 QEASVLRAKTQSLEADNEKLQT--ENKKLQLLKNAKSLRSDKALDLNT--------KKT- 890
Q +R + ++ + QT E K +++ K + L+ DK + + KKT
Sbjct: 981 QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL 1040
Query: 891 TQLENELKEALAKI-------KELEMICQDE---------KSEKK-------VRFTEATK 927
+ ++NE++EAL + ++ CQ++ K E++ V +A K
Sbjct: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAK 1100
Query: 928 KETDTLKS-KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTK 986
++ + S +Q + + LKD+ K + +
Sbjct: 1101 EQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLH 1160
Query: 987 LQLKKMVEDLECEIGEMYVVMKNAGLS--GK------EMTAKTKLEKEIDEIRSKLSKND 1038
Q++K+ + + + E N LS GK E+ + EKEI E R ++++ +
Sbjct: 1161 DQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVE 1220
Query: 1039 S-EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNR 1097
S + L+ E+ +L+D + E +K K A E + + E K
Sbjct: 1221 SLRYRQRVELLERELQELQD-SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKML 1279
Query: 1098 EAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN 1157
+ +L DL+ + + + ++ K + +N
Sbjct: 1280 REEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
Query: 1158 KLL--KEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVL 1215
+ L ++ T++ +++ +++ K + L
Sbjct: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
Query: 1216 ANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVH 1275
++ E + + +L A+ I + K T+ +++ + Y+ T E A +D
Sbjct: 1400 KEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI-TQVKKIGRRYK---TQYEELKAQQD-- 1453
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
K +E + Q++ D ++ S EM E++ + ++ N + L + E E+
Sbjct: 1454 -KVMETSA-QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
+ + QL+S+L++L + E K ++ +S +
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS--------K 1563
Query: 1396 IAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
IAH VK++ E LK + L+Q RIT LK +YE + +LE L +
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQER 1623
Query: 1455 YEELTGKYELLEEEHVVTKARLTVEKEQAQGE 1486
+ E + + + + ++T++ A GE
Sbjct: 1624 HLEQRDEPQEPSNKVPEQQRQITLKTTPASGE 1655
Score = 67.3 bits (157), Expect = 5e-10
Identities = 166/837 (19%), Positives = 356/837 (42%), Gaps = 88/837 (10%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI--LLRRLANIDTANKYTTGRSSE 318
L+ +N++ Q +E + E + ++ ++EK + +I L ++L N + ++T R+ +
Sbjct: 814 LLLTNLQTIQGILE--RSETETKQRLSSQIEKLEHEISHLKKKLEN-EVEQRHTLTRNLD 870
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAA 377
V L K +L T + K+ L +EI + + + E Q Q Q K +
Sbjct: 871 VQLLDTK-RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPS 929
Query: 378 ETL-CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYS---SLRRELEQTIKNCRV 433
++L+ + ++++ DL N + QA S SL +E + T + +
Sbjct: 930 NKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
+ +LK++ QLE++ E EK+ E+ D +R I+ +EQ+++ + +Q
Sbjct: 990 IEVRLKESAEFQTQLEKKLMEVEKEKQEL---QDDKRR--AIESMEQQLSELKKTLSSVQ 1044
Query: 494 RELAEANSKFTG--SNPSLMKVPQPETVKVSRSSLTRGGSQ----EDPAQLLRDLQDSLE 547
E+ EA + + SN + E K++ + + + + L+ ++ +
Sbjct: 1045 NEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
Query: 548 READLREQL----RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM 603
+ A +R+ L + AE + CK ++ +++ M + V+ + E + QN++
Sbjct: 1105 KMASVRQHLEETTQKAESQLLECK----ASWEERERMLKDEVSKCVCRCEDLEK--QNRL 1158
Query: 604 IH------AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+H + +S ++ PL++ + E L L + +T V
Sbjct: 1159 LHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRR--EKEIAETRFEV 1216
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE-TANDNDEKETDEADPAEMKLLLEL 716
+ ESL + + + ++L + A + ++ TA + E M +++E
Sbjct: 1217 AQ-VESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMET 1275
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
N+ +LR + E LEQD + ++ +V++L ++ + A + + + + KL E
Sbjct: 1276 NK----MLREEKERLEQDLQQMQAKVRKL--ELDILPLQEANAELSEKSGMLQAEKKLLE 1329
Query: 777 ERVK------------VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
E VK + + +E RK L EKE +R+ +L+ + K I +
Sbjct: 1330 EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ-QLTEEIGRLKAEIARSNAS 1388
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
++ QN+ +Q ++++ + +R + ++++ D + K + + + K++ K +
Sbjct: 1389 LTNNQNL-----IQSLKEDLNKVRTEKETIQKD-----LDAKIIDIQEKVKTITQVKKIG 1438
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K TQ E ELK K+ E + E+ V E + + +TL +
Sbjct: 1439 RRYK--TQYE-ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELK-ETLNQAETKSKSLE 1494
Query: 945 XXXXXXXXXXXXXQATLKSLKDDA--QKSFKPRIPKKPTDLTT-KLQLKKMVEDLECEIG 1001
+ ++L++ +S R+ + D TT + QL++ + + E +
Sbjct: 1495 SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
Query: 1002 EMYVVMKN--AGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK 1056
+ V K+ A L+G K +L KE +E++ + + +K+ L I LK
Sbjct: 1555 KAIVAAKSKIAHLAG----VKDQLTKENEELKQR----NGALDQQKDELDVRITALK 1603
Score = 64.5 bits (150), Expect = 4e-09
Identities = 230/1234 (18%), Positives = 477/1234 (38%), Gaps = 104/1234 (8%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREI-ESELETRPSTEAQTRQIEQLRAKLLAAET 379
++ +K+ L E+ D +K + E EL T A +I + KL
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
E D+ K E + + + E +A R E E+ K LS KL+
Sbjct: 401 AYVETQDQLLLEKLENKRINKYLDEIVKEV-EAKAPILKRQREEYERAQKAVASLSVKLE 459
Query: 440 KTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ ++ +L+++ KA + +LE D + E ++K+L Q++ L ++ E A
Sbjct: 460 QAMKEIQRLQEDTDKANKQSSVLE----RDNRRMEIQVKDLSQQIR-----VLLMELEEA 510
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
N S + V +S+ ++ +E L + Q L +L E
Sbjct: 511 RGNHVIRDEEVSSADISSSSEV-ISQHLVSYRNIEE----LQQQNQRLLVALRELGETRE 565
Query: 558 NAEEETANCKQVNPPTFLDKQVMT-DNIVTCDIHESETVTNSIQNKMIH--------AAS 608
E+ET + K L+ + + + H+ + V + ++ + ++ +
Sbjct: 566 REEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVA 625
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPY-LSIFNHMAANNLRKTAARVEEDNESLLLQ 667
P D L+ T P + + A + +++E E+
Sbjct: 626 IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENY--- 682
Query: 668 LKKMATKARSRKLSPTPPANKLSIETAN--DNDEKETDEADPAEMKLLLELNEQEATVLR 725
KK KA + K+ KL + + + K + + D A + E+ + R
Sbjct: 683 -KK--EKAENEKIQ-NEQLEKLQEQVTDLRSQNTKISTQLDFASKRY--EMLQDNVEGYR 736
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT-ARRSLTTNSNKLAEERVKVLED 784
R++ L + + L ++ I+++T+ G+N A + + K +E +K+ E
Sbjct: 737 REITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEV 796
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
+ + R+ L+ ++R L L Q I RS + Q+ L Q++ +E E
Sbjct: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQG-----ILERSETETKQR---LSSQIEKLEHEI 848
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAK 903
S L+ K ++ E + T N +QLL + L ++ L LNTK+ + + E+
Sbjct: 849 SHLKKKLEN-EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH 907
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSK----QXXXXXXXXXXXXXXXXXXXXQA 959
+ +E+ + S++ + + K++ D L S+ + QA
Sbjct: 908 LSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQA 967
Query: 960 TLKSLK----------DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ SL+ ++ +K+ + R+ K+ + T+L+ KK++E +E E E+ +
Sbjct: 968 MVTSLEESLNKEKQVTEEVRKNIEVRL-KESAEFQTQLE-KKLME-VEKEKQELQDDKRR 1024
Query: 1010 AGLSGKEMTAKTK--LEKEIDEIRSKLSKNDSEFTNEK--NRLQTEIAKLK-DVNAKLEG 1064
A S ++ ++ K L +E++ L + + +NE+ R E AK+ + K E
Sbjct: 1025 AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYER 1084
Query: 1065 DKDVFANKYKALENENSNLSNQCKT---LTEEMKNREAQINKLSADL-KNATSLQTTMSD 1120
+ + A +AL+ +S L E + E+Q+ + A + L+ +S
Sbjct: 1085 ELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSK 1144
Query: 1121 CMXXXXXXXXXXXXXXXXXXXXXXQVDNYTK--IDQDKNKLLKEVGDKTKKIGDXXXXXX 1178
C+ +V K + N L E G ++I +
Sbjct: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
Query: 1179 XXXXXCK-RIE-KQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR-RLSIELTSEKDELQA 1235
+ R E Q+ + + R Q + A + +++ + ++ +EL
Sbjct: 1205 REKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMK 1264
Query: 1236 RFIKTESKFITLEAE--MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDE 1293
KTE+ + +E +R+ K E + +++ + ++ I L++A ++K
Sbjct: 1265 ---KTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEA-NAELSEKSGM 1320
Query: 1294 ATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLE 1353
+ +++E Q + + + + K +E + QL ++ +L+
Sbjct: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE-EYRKLLSEKEVHTKRIQQLTEEIGRLK 1379
Query: 1354 NXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLK 1413
+N + L DL R + + ++ KD+ DA++ ++
Sbjct: 1380 AEIARSNASLTNN-------QNLIQSLKEDLNKVRTEKETIQ----KDL---DAKIIDIQ 1425
Query: 1414 GKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK 1473
K+K + Q G + T+ ++ + K +E S E+ E+ E + + +
Sbjct: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
Query: 1474 ARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
A + ++Q E ++QK LS E + LQE+
Sbjct: 1486 AETKSKSLESQVE--NLQKTLSEKETEARNLQEQ 1517
Score = 59.3 bits (137), Expect = 1e-07
Identities = 208/1204 (17%), Positives = 460/1204 (38%), Gaps = 105/1204 (8%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAKLLAAETLC 381
Q +++ L +E + E + Q+ EIE L ++ +TR+ + LR +L
Sbjct: 33 QSEIDGLKGRHEKFKVESE---QQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQL 89
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+ L ++N++++ +D +E+ E L R E+ + L+ +K+
Sbjct: 90 KALTEKNKELEIA-QDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRL 148
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRI---KEL--EQEVARSTEVALRLQRE 495
K + K E + KL E+ ++ RE R+ KEL Q +TE+ +
Sbjct: 149 NEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL 208
Query: 496 LAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
LA K G+ +K + + +VSR G + L + ++D L + + +E
Sbjct: 209 LALGREK--GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE 614
Q + EE+ N L+ + N+ +SE +N + + KE
Sbjct: 267 QQASMEEKFHN--------ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKL--LKE 316
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA-- 672
++ D E Q + + + +E N+ L +K A
Sbjct: 317 AGEANKAIQDHLLEVEQSKDQM------EKEMLEKIGRLEKELENANDLLSATKRKGAIL 370
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL-NEQEATVLRRKVEEL 731
++ +SPT A ++ E + + LL +L N++ L V+E+
Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
E LK+Q +E +V SL+ + +E ++ L+++ D+ K
Sbjct: 431 EAKAPILKRQREEYERAQKAVA------------SLSVKLEQAMKE-IQRLQEDTDKANK 477
Query: 792 KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+ ERD R+ ++ ++ + L+ + D + I + V+
Sbjct: 478 QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHL 537
Query: 852 QSLEADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
S + E+LQ +N++L + L+ R + + + K T+L+ +L+ AL ++++L
Sbjct: 538 VSYR-NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLR-- 594
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ + +++ ++ ++ D + +T K + +
Sbjct: 595 ---KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK--RPSTSQ 649
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK--NAGLSGKEMTAKTKLEKEID 1028
+ P + T ++ K ++ L+ EI E Y K N + +++ KL++++
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQ-EIFENYKKEKAENEKIQNEQL---EKLQEQVT 705
Query: 1029 EIRSKLSK--NDSEFTNEKNRL--------QTEIAKLKDVNAKL----EGDKDVFANKYK 1074
++RS+ +K +F +++ + + EI L + N KL + + + +
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXX 1134
L N L+ + E +K +E ++ KLS +++ + ++ +++
Sbjct: 766 DLRGANEKLA-VAEVRAENLK-KEKEMLKLS-EVRLSQQRESLLAE---QRGQNLLLTNL 819
Query: 1135 XXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK----RIEKQ 1190
+ + ++ KL E+ KK+ + ++Q
Sbjct: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI-TLEA 1249
L T + + L + +++ S+ + + + + + L +
Sbjct: 880 LDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939
Query: 1250 EMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
++R E ++ L+ + +++Q + A+ + + ++ E V
Sbjct: 940 QLRQT----EEQVNDLKERLKTSTSNVEQYQ-AMVTSLEESLNKEKQVTEEVRKNIEVRL 994
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
Q E +++ EK E + + + ++ L++L+
Sbjct: 995 KESAEFQTQLEKKLMEVEKEKQELQDDKRR-AIESMEQQLSELKKTLSSVQNEVQEALQR 1053
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
+S + ++ D Q + K + +++++ A++ L+ EQ S +
Sbjct: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA---AKEQVS-----K 1105
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLH 1489
+ ++Q EET +K E L KA +EE + +L++E V+K E + Q LLH
Sbjct: 1106 MASVRQHLEETTQKAESQLLECKASWEE---RERMLKDE--VSKCVCRCEDLEKQNRLLH 1160
Query: 1490 VQKE 1493
Q E
Sbjct: 1161 DQIE 1164
Score = 51.6 bits (118), Expect = 3e-05
Identities = 177/1055 (16%), Positives = 379/1055 (35%), Gaps = 73/1055 (6%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
E+K LE ++E + L ++ L+ E L+K V++L +K+ + A L
Sbjct: 221 ELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELN 280
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+ KL+ + + D+ K E R E LH L A + K I+ L+
Sbjct: 281 AHI-KLSN----LYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKA-IQDHLLEVEQS 334
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
++ K L+ I + L L A K +++ +L + + + +
Sbjct: 335 KDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEE-ELAAMSPTAAAVAKIVKPGM 393
Query: 889 KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
K T+L N E ++ LE + ++ + + + LK ++
Sbjct: 394 KLTELYNAYVETQDQLL-LEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
++ L++D K+ K + + ++Q+K + + + + E+
Sbjct: 453 SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512
Query: 1009 NAGLSGKEMT-AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKD 1067
N + +E++ A E+ +N E + RL + +L + + E ++
Sbjct: 513 NHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE--QE 570
Query: 1068 VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL--SADLKNATSLQTTMSDCMXXX 1125
++K L+ + + + + L + +++ ++ + D+ QTT
Sbjct: 571 TTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHA 630
Query: 1126 XXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK 1185
V + ++ E K++ + +
Sbjct: 631 SSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENE 690
Query: 1186 RIE-KQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+I+ +QL +++VT Q + + L + + E+ + + +
Sbjct: 691 KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT 750
Query: 1245 ITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMR 1304
T + + + + ++ + +A +V + L+ +K S V + + R
Sbjct: 751 ATTQKQEQIINTMTQD-LRGANEKLAVAEVRAENLK-------KEKEMLKLSEVRLSQQR 802
Query: 1305 XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXX 1364
L + LE++E E+ +L S + KLE+
Sbjct: 803 ESLLAEQRGQNLLLTNLQTIQGILERSETETKQ------RLSSQIEKLEHEISHLKKKLE 856
Query: 1365 XXXXXSSYWENKAKELDTDLQSERKKLDRMRIAH--DKDV-KNKDAELATLKGKLKILE- 1420
+ LD L +++LD H K++ KN E+ATLK L +E
Sbjct: 857 NEVEQR---HTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
Query: 1421 -------QNSGAGAKR--------ITELKQEYEETVKKLEHSLALEKAEYEE----LTGK 1461
Q +G G +++L+Q EE V L+ L + E+ +T
Sbjct: 914 QVASQSSQRTGKGQPSNKEDVDDLVSQLRQT-EEQVNDLKERLKTSTSNVEQYQAMVTSL 972
Query: 1462 YELLEEEHVVTK-ARLTVE---KEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNT 1517
E L +E VT+ R +E KE A+ + ++K+L E + LQ+ +
Sbjct: 973 EESLNKEKQVTEEVRKNIEVRLKESAEFQT-QLEKKLMEVEKEKQELQDDKRRAIESMEQ 1031
Query: 1518 EKTEMQNSIASLQERLCGGGWEVERARLNARLDQRE--RELRAANDRRDVLEHHHDXXXX 1575
+ +E++ +++S+Q + A N + +R+ + + A + ++ E
Sbjct: 1032 QLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAA 1091
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
+++ +++ E+ E+ K E++ R E
Sbjct: 1092 DVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCED 1151
Query: 1636 ---QMNTMRDELKSLHNQVSRFRRE--RDNYKQMLEAAQKSMAEIKN------GDKSARI 1684
Q + D+++ L ++V +E + L KS +I +K
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE 1211
Query: 1685 HRNSISSTDEEEYRNKVALLEQQVACLEDELCESR 1719
R ++ + YR +V LLE+++ L+D L R
Sbjct: 1212 TRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
Score = 49.2 bits (112), Expect = 1e-04
Identities = 81/362 (22%), Positives = 146/362 (40%), Gaps = 26/362 (7%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR- 1284
L EK+ L ++ ++ T E+ L + N+I L+ + K + +LE+ +
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNG 242
Query: 1285 -QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE---KTEAESSAAKL 1340
+T+N+ + + + +++ +EL NA IKL K+ A+ S AK
Sbjct: 243 LKTSNEHLQKHVEDL-LTKLKEAKEQQASMEEKFHNEL-NAHIKLSNLYKSAADDSEAKS 300
Query: 1341 -EMAQLKSDLAK-LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL----DRM 1394
E+ + +L K L+ + KE+ + K+L D +
Sbjct: 301 NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL 360
Query: 1395 RIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
K + ELA + + + G K +TEL Y ET + L LEK E
Sbjct: 361 SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMK-LTELYNAYVET----QDQLLLEKLE 415
Query: 1455 YEELTGKY--ELLEEEHVVTK--ARLTVEKEQAQGELLHVQKELSTALGEIKTLQE---K 1507
+ + KY E+++E R E E+AQ + + +L A+ EI+ LQE K
Sbjct: 416 NKRI-NKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDK 474
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+S+ + M+ + L +++ E+E AR N + E + +V+
Sbjct: 475 ANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVIS 534
Query: 1568 HH 1569
H
Sbjct: 535 QH 536
Score = 48.0 bits (109), Expect = 3e-04
Identities = 78/428 (18%), Positives = 171/428 (39%), Gaps = 30/428 (7%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
++L+ L++ +K + IA D+++ + ++ K +L+ +++ +R+++ +
Sbjct: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQ-SQFTRTKEELEAEKRDLIRTNERLSQELEYL 141
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK---ARLTVEKEQAQGELLHVQKEL 1494
E VK+L L EL K + L+ V K RL EKE + + EL
Sbjct: 142 TEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL 201
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
T E+ L + G E + ++ L+E++ G + L ++
Sbjct: 202 KTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM--NGLKTSNEHLQKHVEDLLT 259
Query: 1555 ELRAANDRRDVLEH--HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+L+ A +++ +E H++ + +K
Sbjct: 260 KLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAK--------SNELTRAVEELH 311
Query: 1613 XXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSM 1672
++++ +A KA I D E + M K + ++ R +E +N +L A ++
Sbjct: 312 KLLKEAGEANKA-IQDHLLEVEQSKDQME---KEMLEKIGRLEKELENANDLLSATKRKG 367
Query: 1673 AEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSE 1732
A I + ++ A + + + + K+ L +D+L +L ++N L
Sbjct: 368 A-ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
Query: 1733 KSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAW---HKERDEQQRLLQETS 1789
E + ++ + EYE + VA L+ ++E A + +++ + +++S
Sbjct: 427 VKEVEAKAPILKRQREEYER------AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
Query: 1790 TLARDLRQ 1797
L RD R+
Sbjct: 481 VLERDNRR 488
Score = 46.4 bits (105), Expect = 0.001
Identities = 147/897 (16%), Positives = 351/897 (39%), Gaps = 59/897 (6%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR--RLANIDTANKYTTGRSSE 318
L+ +N + Q+ +E L ++V L ++ + K ++ L+ L D + KY R +
Sbjct: 127 LIRTNERLSQE-LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQ 185
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQLRAKLLAA 377
+L N T N +L+ + L RE +E LE + + E + ++ +L ++
Sbjct: 186 EKELLHSQN--TWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFRED-------------QADEYSSLRREL 424
+T E L ED+ +L++ M++ F + AD+ + EL
Sbjct: 244 KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
Query: 425 EQTIKNCRVLSFKLKKTERKAD----QLEQEKAEHEKKLLEIVGGPD-GMQREN-RIKEL 478
+ ++ L + + + ++EQ K + EK++LE +G + ++ N +
Sbjct: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
Query: 479 EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQL 538
+++ A +E L A A +K L ++ V+ L + +
Sbjct: 364 KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL-YNAYVETQDQLLLEKLENKRINKY 422
Query: 539 LRDLQDSLEREADL----REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD----IH 590
L ++ +E +A + RE+ A++ A+ + Q + ++ + +
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL 650
E + IQ K + E ++ + + E + I H+ +
Sbjct: 483 ERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVS--- 539
Query: 651 RKTAARVEEDNESLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE 709
+ +++ N+ LL+ L+++ T+ R + + + +L ++ + E E
Sbjct: 540 YRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQH 599
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
L++ ++ + R + + L + S S+ + S + +
Sbjct: 600 QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPV 659
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
+ A E L+ ++ E+ + +++ + E++ E ++ T ++S++ S Q
Sbjct: 660 IESTEAIEAKAALK-QLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ KR ++++ R + SL N+KL +K + + N + A +
Sbjct: 719 DFASKR-YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVA 777
Query: 890 TTQLENELKE-ALAKIKELEMICQDEK--SEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
+ EN KE + K+ E+ + Q E +E++ + T +T ++
Sbjct: 778 EVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL 837
Query: 947 XXXXXXXXXXXQATLKSLKDDAQ------KSFKPRI--PKKPTDLTTKLQL--KKMVEDL 996
K L+++ + ++ ++ K+ D T L L K+++++
Sbjct: 838 SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNA 897
Query: 997 ECEIGEMYVVMKN----AGLSGKEMTAK--TKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ EI + + N + T K ++++D++ S+L + + + + K RL+T
Sbjct: 898 QKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKT 957
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ ++ A + ++ + + E N+ + K E E ++ ++ +
Sbjct: 958 STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE 1014
Score = 41.5 bits (93), Expect = 0.030
Identities = 82/454 (18%), Positives = 185/454 (40%), Gaps = 37/454 (8%)
Query: 272 QIEGLK--QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q+E L+ Q V++L ER +E D L + K T + E++K + +N +
Sbjct: 1218 QVESLRYRQRVELL----ERELQELQDSLNAEREKVQVTAK-TMAQHEELMKKTETMNVV 1272
Query: 330 TTHNEDLRDEKKHLTQKIREIES-----ELETRPSTEAQTRQIEQLRAKLLAAETLCEE- 383
N+ LR+EK+ L Q ++++++ EL+ P EA ++ + L A + L EE
Sbjct: 1273 METNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA-ELSEKSGMLQAEKKLLEED 1331
Query: 384 ----------LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRV 433
L+ + +D E + + +E L+ E+ ++ +
Sbjct: 1332 VKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL-LEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ + +++ EK +K L +I+ + ++ ++K++ + E
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451
Query: 493 QRELAEANSKFTGSNPSL-MKVPQPETVKVS-RSSLTRGGSQEDPAQLLRDLQDSLEREA 550
Q ++ E +++ +G + + V + + +K + + T+ S E + L+ E EA
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 551 -DLREQLRNAEEETANCKQ-VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
+L+EQ + E + +Q + T ++Q+ +T ++ + ++K+ H A
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAKSKIAHLAG 1569
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAA------NNLRKTAARVEEDNE 662
K + + ++ + D+ ++ + LR+ R E +
Sbjct: 1570 VKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRD 1629
Query: 663 SLLLQLKKMATKARSRKLSPTPPANKLSIETAND 696
K+ + R L TP + + I + +D
Sbjct: 1630 EPQEPSNKVPEQQRQITLKTTPASGERGIASTSD 1663
>AL133553-3|CAI17859.1| 2363|Homo sapiens translocated promoter region
(to activated MET oncogene) protein.
Length = 2363
Score = 77.0 bits (181), Expect = 6e-13
Identities = 234/1292 (18%), Positives = 495/1292 (38%), Gaps = 113/1292 (8%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKE---KSDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
E QDQ+ K E + K + + KE K+ IL R+ + A K S ++ + +
Sbjct: 404 ETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMK 463
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAK--LLAAETLC 381
++ L + + L + R +E ++ + ++E+ R + E
Sbjct: 464 EIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQA-DEYSSLRRELEQTIKNCRVLSFKLKK 440
++ +E + + L Q N R A E R EQ + ++ +LK
Sbjct: 524 ADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK- 582
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE-LAEA 499
E +LEQ + + ++ ++V D + R+ + + ++++T VA+ L L +
Sbjct: 583 LESALTELEQLRKSRQHQM-QLV---DSIVRQRDMYRIL--LSQTTGVAIPLHASSLDDV 636
Query: 500 NSKFTGSNPSL---MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLEREADLREQ 555
+ T PS + P P V S ++ + + ++ + + + E E EQ
Sbjct: 637 SLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ 696
Query: 556 LRNAEEETANCKQVNPP--TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
L +E+ + + N T LD ++ ++ S+ + +T +
Sbjct: 697 LEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQ 756
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMAT 673
E+ I+ T++ + + ++ + A NL+K ++ L Q + +
Sbjct: 757 EQI------INTMTQDLRGANEKLAVA---EVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
Query: 674 KARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQ 733
+ R + L T N +I+ + E ET + ++++ L E E + L++K+E +
Sbjct: 808 EQRGQNLLLT---NLQTIQGILERSETETKQRLSSQIEKL----EHEISHLKKKLENEVE 860
Query: 734 DKEALKKQ--VKELTSKISSVTKTSAGSNT-----TARRSLTTNSNKLAEERVKVLEDEI 786
+ L + V+ L +K T+T+ NT A++ + T L+ V+V
Sbjct: 861 QRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSS 920
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTL---IKSRSLDASDQQNV--DLKRQLQVIE 841
K + D + L ++L +++ L +K+ + + Q + L+ L +
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK 980
Query: 842 QEASVLRAKTQSLEADNEKLQT--ENKKLQLLKNAKSLRSDKALDLNT--------KKT- 890
Q +R + ++ + QT E K +++ K + L+ DK + + KKT
Sbjct: 981 QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL 1040
Query: 891 TQLENELKEALAKI-------KELEMICQDE---------KSEKK-------VRFTEATK 927
+ ++NE++EAL + ++ CQ++ K E++ V +A K
Sbjct: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAK 1100
Query: 928 KETDTLKS-KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTK 986
++ + S +Q + + LKD+ K + +
Sbjct: 1101 EQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLH 1160
Query: 987 LQLKKMVEDLECEIGEMYVVMKNAGLS--GK------EMTAKTKLEKEIDEIRSKLSKND 1038
Q++K+ + + + E N LS GK E+ + EKEI E R ++++ +
Sbjct: 1161 DQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVE 1220
Query: 1039 S-EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNR 1097
S + L+ E+ +L+D + E +K K A E + + E K
Sbjct: 1221 SLRYRQRVELLERELQELQD-SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKML 1279
Query: 1098 EAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN 1157
+ +L DL+ + + + ++ K + +N
Sbjct: 1280 REEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
Query: 1158 KLL--KEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVL 1215
+ L ++ T++ +++ +++ K + L
Sbjct: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
Query: 1216 ANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVH 1275
++ E + + +L A+ I + K T+ +++ + Y+ T E A +D
Sbjct: 1400 KEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI-TQVKKIGRRYK---TQYEELKAQQD-- 1453
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
K +E + Q++ D ++ S EM E++ + ++ N + L + E E+
Sbjct: 1454 -KVMETSA-QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
+ + QL+S+L++L + E K ++ +S +
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS--------K 1563
Query: 1396 IAHDKDVKNK-DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
IAH VK++ E LK + L+Q RIT LK +YE + +LE L +
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQER 1623
Query: 1455 YEELTGKYELLEEEHVVTKARLTVEKEQAQGE 1486
+ E + + + + ++T++ A GE
Sbjct: 1624 HLEQRDEPQEPSNKVPEQQRQITLKTTPASGE 1655
Score = 67.3 bits (157), Expect = 5e-10
Identities = 166/837 (19%), Positives = 356/837 (42%), Gaps = 88/837 (10%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI--LLRRLANIDTANKYTTGRSSE 318
L+ +N++ Q +E + E + ++ ++EK + +I L ++L N + ++T R+ +
Sbjct: 814 LLLTNLQTIQGILE--RSETETKQRLSSQIEKLEHEISHLKKKLEN-EVEQRHTLTRNLD 870
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAA 377
V L K +L T + K+ L +EI + + + E Q Q Q K +
Sbjct: 871 VQLLDTK-RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPS 929
Query: 378 ETL-CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYS---SLRRELEQTIKNCRV 433
++L+ + ++++ DL N + QA S SL +E + T + +
Sbjct: 930 NKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
+ +LK++ QLE++ E EK+ E+ D +R I+ +EQ+++ + +Q
Sbjct: 990 IEVRLKESAEFQTQLEKKLMEVEKEKQEL---QDDKRR--AIESMEQQLSELKKTLSSVQ 1044
Query: 494 RELAEANSKFTG--SNPSLMKVPQPETVKVSRSSLTRGGSQ----EDPAQLLRDLQDSLE 547
E+ EA + + SN + E K++ + + + + L+ ++ +
Sbjct: 1045 NEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
Query: 548 READLREQL----RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM 603
+ A +R+ L + AE + CK ++ +++ M + V+ + E + QN++
Sbjct: 1105 KMASVRQHLEETTQKAESQLLECK----ASWEERERMLKDEVSKCVCRCEDLEK--QNRL 1158
Query: 604 IH------AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+H + +S ++ PL++ + E L L + +T V
Sbjct: 1159 LHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRR--EKEIAETRFEV 1216
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE-TANDNDEKETDEADPAEMKLLLEL 716
+ ESL + + + ++L + A + ++ TA + E M +++E
Sbjct: 1217 AQ-VESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMET 1275
Query: 717 NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
N+ +LR + E LEQD + ++ +V++L ++ + A + + + + KL E
Sbjct: 1276 NK----MLREEKERLEQDLQQMQAKVRKL--ELDILPLQEANAELSEKSGMLQAEKKLLE 1329
Query: 777 ERVK------------VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
E VK + + +E RK L EKE +R+ +L+ + K I +
Sbjct: 1330 EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ-QLTEEIGRLKAEIARSNAS 1388
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
++ QN+ +Q ++++ + +R + ++++ D + K + + + K++ K +
Sbjct: 1389 LTNNQNL-----IQSLKEDLNKVRTEKETIQKD-----LDAKIIDIQEKVKTITQVKKIG 1438
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K TQ E ELK K+ E + E+ V E + + +TL +
Sbjct: 1439 RRYK--TQYE-ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELK-ETLNQAETKSKSLE 1494
Query: 945 XXXXXXXXXXXXXQATLKSLKDDA--QKSFKPRIPKKPTDLTT-KLQLKKMVEDLECEIG 1001
+ ++L++ +S R+ + D TT + QL++ + + E +
Sbjct: 1495 SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
Query: 1002 EMYVVMKN--AGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK 1056
+ V K+ A L+G K +L KE +E++ + + +K+ L I LK
Sbjct: 1555 KAIVAAKSKIAHLAG----VKDQLTKENEELKQR----NGALDQQKDELDVRITALK 1603
Score = 64.5 bits (150), Expect = 4e-09
Identities = 230/1234 (18%), Positives = 477/1234 (38%), Gaps = 104/1234 (8%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREI-ESELETRPSTEAQTRQIEQLRAKLLAAET 379
++ +K+ L E+ D +K + E EL T A +I + KL
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
E D+ K E + + + E +A R E E+ K LS KL+
Sbjct: 401 AYVETQDQLLLEKLENKRINKYLDEIVKEV-EAKAPILKRQREEYERAQKAVASLSVKLE 459
Query: 440 KTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ ++ +L+++ KA + +LE D + E ++K+L Q++ L ++ E A
Sbjct: 460 QAMKEIQRLQEDTDKANKQSSVLE----RDNRRMEIQVKDLSQQIR-----VLLMELEEA 510
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
N S + V +S+ ++ +E L + Q L +L E
Sbjct: 511 RGNHVIRDEEVSSADISSSSEV-ISQHLVSYRNIEE----LQQQNQRLLVALRELGETRE 565
Query: 558 NAEEETANCKQVNPPTFLDKQVMT-DNIVTCDIHESETVTNSIQNKMIH--------AAS 608
E+ET + K L+ + + + H+ + V + ++ + ++ +
Sbjct: 566 REEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVA 625
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPY-LSIFNHMAANNLRKTAARVEEDNESLLLQ 667
P D L+ T P + + A + +++E E+
Sbjct: 626 IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENY--- 682
Query: 668 LKKMATKARSRKLSPTPPANKLSIETAN--DNDEKETDEADPAEMKLLLELNEQEATVLR 725
KK KA + K+ KL + + + K + + D A + E+ + R
Sbjct: 683 -KK--EKAENEKIQ-NEQLEKLQEQVTDLRSQNTKISTQLDFASKRY--EMLQDNVEGYR 736
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT-ARRSLTTNSNKLAEERVKVLED 784
R++ L + + L ++ I+++T+ G+N A + + K +E +K+ E
Sbjct: 737 REITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEV 796
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
+ + R+ L+ ++R L L Q I RS + Q+ L Q++ +E E
Sbjct: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQG-----ILERSETETKQR---LSSQIEKLEHEI 848
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAK 903
S L+ K ++ E + T N +QLL + L ++ L LNTK+ + + E+
Sbjct: 849 SHLKKKLEN-EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH 907
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSK----QXXXXXXXXXXXXXXXXXXXXQA 959
+ +E+ + S++ + + K++ D L S+ + QA
Sbjct: 908 LSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQA 967
Query: 960 TLKSLK----------DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ SL+ ++ +K+ + R+ K+ + T+L+ KK++E +E E E+ +
Sbjct: 968 MVTSLEESLNKEKQVTEEVRKNIEVRL-KESAEFQTQLE-KKLME-VEKEKQELQDDKRR 1024
Query: 1010 AGLSGKEMTAKTK--LEKEIDEIRSKLSKNDSEFTNEK--NRLQTEIAKLK-DVNAKLEG 1064
A S ++ ++ K L +E++ L + + +NE+ R E AK+ + K E
Sbjct: 1025 AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYER 1084
Query: 1065 DKDVFANKYKALENENSNLSNQCKT---LTEEMKNREAQINKLSADL-KNATSLQTTMSD 1120
+ + A +AL+ +S L E + E+Q+ + A + L+ +S
Sbjct: 1085 ELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSK 1144
Query: 1121 CMXXXXXXXXXXXXXXXXXXXXXXQVDNYTK--IDQDKNKLLKEVGDKTKKIGDXXXXXX 1178
C+ +V K + N L E G ++I +
Sbjct: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
Query: 1179 XXXXXCK-RIE-KQLSTRKDRVTXXXXXXXXXXXQAVVLANTHR-RLSIELTSEKDELQA 1235
+ R E Q+ + + R Q + A + +++ + ++ +EL
Sbjct: 1205 REKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMK 1264
Query: 1236 RFIKTESKFITLEAE--MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDE 1293
KTE+ + +E +R+ K E + +++ + ++ I L++A ++K
Sbjct: 1265 ---KTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEA-NAELSEKSGM 1320
Query: 1294 ATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLE 1353
+ +++E Q + + + + K +E + QL ++ +L+
Sbjct: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE-EYRKLLSEKEVHTKRIQQLTEEIGRLK 1379
Query: 1354 NXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLK 1413
+N + L DL R + + ++ KD+ DA++ ++
Sbjct: 1380 AEIARSNASLTNN-------QNLIQSLKEDLNKVRTEKETIQ----KDL---DAKIIDIQ 1425
Query: 1414 GKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK 1473
K+K + Q G + T+ ++ + K +E S E+ E+ E + + +
Sbjct: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
Query: 1474 ARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
A + ++Q E ++QK LS E + LQE+
Sbjct: 1486 AETKSKSLESQVE--NLQKTLSEKETEARNLQEQ 1517
Score = 59.3 bits (137), Expect = 1e-07
Identities = 208/1204 (17%), Positives = 460/1204 (38%), Gaps = 105/1204 (8%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAKLLAAETLC 381
Q +++ L +E + E + Q+ EIE L ++ +TR+ + LR +L
Sbjct: 33 QSEIDGLKGRHEKFKVESE---QQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQL 89
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+ L ++N++++ +D +E+ E L R E+ + L+ +K+
Sbjct: 90 KALTEKNKELEIA-QDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRL 148
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRI---KEL--EQEVARSTEVALRLQRE 495
K + K E + KL E+ ++ RE R+ KEL Q +TE+ +
Sbjct: 149 NEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL 208
Query: 496 LAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
LA K G+ +K + + +VSR G + L + ++D L + + +E
Sbjct: 209 LALGREK--GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE 614
Q + EE+ N L+ + N+ +SE +N + + KE
Sbjct: 267 QQASMEEKFHN--------ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKL--LKE 316
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA-- 672
++ D E Q + + + +E N+ L +K A
Sbjct: 317 AGEANKAIQDHLLEVEQSKDQM------EKEMLEKIGRLEKELENANDLLSATKRKGAIL 370
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL-NEQEATVLRRKVEEL 731
++ +SPT A ++ E + + LL +L N++ L V+E+
Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
E LK+Q +E +V SL+ + +E ++ L+++ D+ K
Sbjct: 431 EAKAPILKRQREEYERAQKAVA------------SLSVKLEQAMKE-IQRLQEDTDKANK 477
Query: 792 KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+ ERD R+ ++ ++ + L+ + D + I + V+
Sbjct: 478 QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHL 537
Query: 852 QSLEADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
S + E+LQ +N++L + L+ R + + + K T+L+ +L+ AL ++++L
Sbjct: 538 VSYR-NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLR-- 594
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ + +++ ++ ++ D + +T K + +
Sbjct: 595 ---KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK--RPSTSQ 649
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK--NAGLSGKEMTAKTKLEKEID 1028
+ P + T ++ K ++ L+ EI E Y K N + +++ KL++++
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQ-EIFENYKKEKAENEKIQNEQL---EKLQEQVT 705
Query: 1029 EIRSKLSK--NDSEFTNEKNRL--------QTEIAKLKDVNAKL----EGDKDVFANKYK 1074
++RS+ +K +F +++ + + EI L + N KL + + + +
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXX 1134
L N L+ + E +K +E ++ KLS +++ + ++ +++
Sbjct: 766 DLRGANEKLA-VAEVRAENLK-KEKEMLKLS-EVRLSQQRESLLAE---QRGQNLLLTNL 819
Query: 1135 XXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK----RIEKQ 1190
+ + ++ KL E+ KK+ + ++Q
Sbjct: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI-TLEA 1249
L T + + L + +++ S+ + + + + + L +
Sbjct: 880 LDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939
Query: 1250 EMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
++R E ++ L+ + +++Q + A+ + + ++ E V
Sbjct: 940 QLRQT----EEQVNDLKERLKTSTSNVEQYQ-AMVTSLEESLNKEKQVTEEVRKNIEVRL 994
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
Q E +++ EK E + + + ++ L++L+
Sbjct: 995 KESAEFQTQLEKKLMEVEKEKQELQDDKRR-AIESMEQQLSELKKTLSSVQNEVQEALQR 1053
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
+S + ++ D Q + K + +++++ A++ L+ EQ S +
Sbjct: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA---AKEQVS-----K 1105
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLH 1489
+ ++Q EET +K E L KA +EE + +L++E V+K E + Q LLH
Sbjct: 1106 MASVRQHLEETTQKAESQLLECKASWEE---RERMLKDE--VSKCVCRCEDLEKQNRLLH 1160
Query: 1490 VQKE 1493
Q E
Sbjct: 1161 DQIE 1164
Score = 51.6 bits (118), Expect = 3e-05
Identities = 177/1055 (16%), Positives = 379/1055 (35%), Gaps = 73/1055 (6%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
E+K LE ++E + L ++ L+ E L+K V++L +K+ + A L
Sbjct: 221 ELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELN 280
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+ KL+ + + D+ K E R E LH L A + K I+ L+
Sbjct: 281 AHI-KLSN----LYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKA-IQDHLLEVEQS 334
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
++ K L+ I + L L A K +++ +L + + + +
Sbjct: 335 KDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEE-ELAAMSPTAAAVAKIVKPGM 393
Query: 889 KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
K T+L N E ++ LE + ++ + + + LK ++
Sbjct: 394 KLTELYNAYVETQDQLL-LEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
++ L++D K+ K + + ++Q+K + + + + E+
Sbjct: 453 SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512
Query: 1009 NAGLSGKEMT-AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKD 1067
N + +E++ A E+ +N E + RL + +L + + E ++
Sbjct: 513 NHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE--QE 570
Query: 1068 VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL--SADLKNATSLQTTMSDCMXXX 1125
++K L+ + + + + L + +++ ++ + D+ QTT
Sbjct: 571 TTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHA 630
Query: 1126 XXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCK 1185
V + ++ E K++ + +
Sbjct: 631 SSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENE 690
Query: 1186 RIE-KQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
+I+ +QL +++VT Q + + L + + E+ + + +
Sbjct: 691 KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT 750
Query: 1245 ITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMR 1304
T + + + + ++ + +A +V + L+ +K S V + + R
Sbjct: 751 ATTQKQEQIINTMTQD-LRGANEKLAVAEVRAENLK-------KEKEMLKLSEVRLSQQR 802
Query: 1305 XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXX 1364
L + LE++E E+ +L S + KLE+
Sbjct: 803 ESLLAEQRGQNLLLTNLQTIQGILERSETETKQ------RLSSQIEKLEHEISHLKKKLE 856
Query: 1365 XXXXXSSYWENKAKELDTDLQSERKKLDRMRIAH--DKDV-KNKDAELATLKGKLKILE- 1420
+ LD L +++LD H K++ KN E+ATLK L +E
Sbjct: 857 NEVEQR---HTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
Query: 1421 -------QNSGAGAKR--------ITELKQEYEETVKKLEHSLALEKAEYEE----LTGK 1461
Q +G G +++L+Q EE V L+ L + E+ +T
Sbjct: 914 QVASQSSQRTGKGQPSNKEDVDDLVSQLRQT-EEQVNDLKERLKTSTSNVEQYQAMVTSL 972
Query: 1462 YELLEEEHVVTK-ARLTVE---KEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNT 1517
E L +E VT+ R +E KE A+ + ++K+L E + LQ+ +
Sbjct: 973 EESLNKEKQVTEEVRKNIEVRLKESAEFQT-QLEKKLMEVEKEKQELQDDKRRAIESMEQ 1031
Query: 1518 EKTEMQNSIASLQERLCGGGWEVERARLNARLDQRE--RELRAANDRRDVLEHHHDXXXX 1575
+ +E++ +++S+Q + A N + +R+ + + A + ++ E
Sbjct: 1032 QLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAA 1091
Query: 1576 XXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEG 1635
+++ +++ E+ E+ K E++ R E
Sbjct: 1092 DVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCED 1151
Query: 1636 ---QMNTMRDELKSLHNQVSRFRRE--RDNYKQMLEAAQKSMAEIKN------GDKSARI 1684
Q + D+++ L ++V +E + L KS +I +K
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE 1211
Query: 1685 HRNSISSTDEEEYRNKVALLEQQVACLEDELCESR 1719
R ++ + YR +V LLE+++ L+D L R
Sbjct: 1212 TRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
Score = 49.2 bits (112), Expect = 1e-04
Identities = 81/362 (22%), Positives = 146/362 (40%), Gaps = 26/362 (7%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR- 1284
L EK+ L ++ ++ T E+ L + N+I L+ + K + +LE+ +
Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNG 242
Query: 1285 -QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE---KTEAESSAAKL 1340
+T+N+ + + + +++ +EL NA IKL K+ A+ S AK
Sbjct: 243 LKTSNEHLQKHVEDL-LTKLKEAKEQQASMEEKFHNEL-NAHIKLSNLYKSAADDSEAKS 300
Query: 1341 -EMAQLKSDLAK-LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL----DRM 1394
E+ + +L K L+ + KE+ + K+L D +
Sbjct: 301 NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL 360
Query: 1395 RIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
K + ELA + + + G K +TEL Y ET + L LEK E
Sbjct: 361 SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMK-LTELYNAYVET----QDQLLLEKLE 415
Query: 1455 YEELTGKY--ELLEEEHVVTK--ARLTVEKEQAQGELLHVQKELSTALGEIKTLQE---K 1507
+ + KY E+++E R E E+AQ + + +L A+ EI+ LQE K
Sbjct: 416 NKRI-NKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDK 474
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+S+ + M+ + L +++ E+E AR N + E + +V+
Sbjct: 475 ANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVIS 534
Query: 1568 HH 1569
H
Sbjct: 535 QH 536
Score = 48.0 bits (109), Expect = 3e-04
Identities = 78/428 (18%), Positives = 171/428 (39%), Gaps = 30/428 (7%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
++L+ L++ +K + IA D+++ + ++ K +L+ +++ +R+++ +
Sbjct: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQ-SQFTRTKEELEAEKRDLIRTNERLSQELEYL 141
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK---ARLTVEKEQAQGELLHVQKEL 1494
E VK+L L EL K + L+ V K RL EKE + + EL
Sbjct: 142 TEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL 201
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
T E+ L + G E + ++ L+E++ G + L ++
Sbjct: 202 KTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM--NGLKTSNEHLQKHVEDLLT 259
Query: 1555 ELRAANDRRDVLEH--HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+L+ A +++ +E H++ + +K
Sbjct: 260 KLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAK--------SNELTRAVEELH 311
Query: 1613 XXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSM 1672
++++ +A KA I D E + M K + ++ R +E +N +L A ++
Sbjct: 312 KLLKEAGEANKA-IQDHLLEVEQSKDQME---KEMLEKIGRLEKELENANDLLSATKRKG 367
Query: 1673 AEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSE 1732
A I + ++ A + + + + K+ L +D+L +L ++N L
Sbjct: 368 A-ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
Query: 1733 KSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAW---HKERDEQQRLLQETS 1789
E + ++ + EYE + VA L+ ++E A + +++ + +++S
Sbjct: 427 VKEVEAKAPILKRQREEYER------AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
Query: 1790 TLARDLRQ 1797
L RD R+
Sbjct: 481 VLERDNRR 488
Score = 46.4 bits (105), Expect = 0.001
Identities = 147/897 (16%), Positives = 351/897 (39%), Gaps = 59/897 (6%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR--RLANIDTANKYTTGRSSE 318
L+ +N + Q+ +E L ++V L ++ + K ++ L+ L D + KY R +
Sbjct: 127 LIRTNERLSQE-LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQ 185
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQLRAKLLAA 377
+L N T N +L+ + L RE +E LE + + E + ++ +L ++
Sbjct: 186 EKELLHSQN--TWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFRED-------------QADEYSSLRREL 424
+T E L ED+ +L++ M++ F + AD+ + EL
Sbjct: 244 KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
Query: 425 EQTIKNCRVLSFKLKKTERKAD----QLEQEKAEHEKKLLEIVGGPD-GMQREN-RIKEL 478
+ ++ L + + + ++EQ K + EK++LE +G + ++ N +
Sbjct: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
Query: 479 EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQL 538
+++ A +E L A A +K L ++ V+ L + +
Sbjct: 364 KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTEL-YNAYVETQDQLLLEKLENKRINKY 422
Query: 539 LRDLQDSLEREADL----REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD----IH 590
L ++ +E +A + RE+ A++ A+ + Q + ++ + +
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL 650
E + IQ K + E ++ + + E + I H+ +
Sbjct: 483 ERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVS--- 539
Query: 651 RKTAARVEEDNESLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE 709
+ +++ N+ LL+ L+++ T+ R + + + +L ++ + E E
Sbjct: 540 YRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQH 599
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
L++ ++ + R + + L + S S+ + S + +
Sbjct: 600 QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPV 659
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
+ A E L+ ++ E+ + +++ + E++ E ++ T ++S++ S Q
Sbjct: 660 IESTEAIEAKAALK-QLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ KR ++++ R + SL N+KL +K + + N + A +
Sbjct: 719 DFASKR-YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVA 777
Query: 890 TTQLENELKE-ALAKIKELEMICQDEK--SEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
+ EN KE + K+ E+ + Q E +E++ + T +T ++
Sbjct: 778 EVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL 837
Query: 947 XXXXXXXXXXXQATLKSLKDDAQ------KSFKPRI--PKKPTDLTTKLQL--KKMVEDL 996
K L+++ + ++ ++ K+ D T L L K+++++
Sbjct: 838 SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNA 897
Query: 997 ECEIGEMYVVMKN----AGLSGKEMTAK--TKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+ EI + + N + T K ++++D++ S+L + + + + K RL+T
Sbjct: 898 QKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKT 957
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ ++ A + ++ + + E N+ + K E E ++ ++ +
Sbjct: 958 STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE 1014
Score = 41.5 bits (93), Expect = 0.030
Identities = 82/454 (18%), Positives = 185/454 (40%), Gaps = 37/454 (8%)
Query: 272 QIEGLK--QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q+E L+ Q V++L ER +E D L + K T + E++K + +N +
Sbjct: 1218 QVESLRYRQRVELL----ERELQELQDSLNAEREKVQVTAK-TMAQHEELMKKTETMNVV 1272
Query: 330 TTHNEDLRDEKKHLTQKIREIES-----ELETRPSTEAQTRQIEQLRAKLLAAETLCEE- 383
N+ LR+EK+ L Q ++++++ EL+ P EA ++ + L A + L EE
Sbjct: 1273 METNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA-ELSEKSGMLQAEKKLLEED 1331
Query: 384 ----------LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRV 433
L+ + +D E + + +E L+ E+ ++ +
Sbjct: 1332 VKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKL-LEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ + +++ EK +K L +I+ + ++ ++K++ + E
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451
Query: 493 QRELAEANSKFTGSNPSL-MKVPQPETVKVS-RSSLTRGGSQEDPAQLLRDLQDSLEREA 550
Q ++ E +++ +G + + V + + +K + + T+ S E + L+ E EA
Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
Query: 551 -DLREQLRNAEEETANCKQ-VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
+L+EQ + E + +Q + T ++Q+ +T ++ + ++K+ H A
Sbjct: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAKSKIAHLAG 1569
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAA------NNLRKTAARVEEDNE 662
K + + ++ + D+ ++ + LR+ R E +
Sbjct: 1570 VKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRD 1629
Query: 663 SLLLQLKKMATKARSRKLSPTPPANKLSIETAND 696
K+ + R L TP + + I + +D
Sbjct: 1630 EPQEPSNKVPEQQRQITLKTTPASGERGIASTSD 1663
>AL049569-3|CAI20363.1| 2017|Homo sapiens ciliary rootlet coiled-coil,
rootletin protein.
Length = 2017
Score = 77.0 bits (181), Expect = 6e-13
Identities = 239/1266 (18%), Positives = 483/1266 (38%), Gaps = 89/1266 (7%)
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESEL------ETRPSTEAQTRQI--EQLRAKLLAAET 379
+L + +L ++ T+ +++ES L + R ++ AQ + EQL A +
Sbjct: 193 QLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 252
Query: 380 LCEELMDENEDM---KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
L E++ D +KEL +++F ++E+S L Q + R++S
Sbjct: 253 LSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSE 312
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEI-VGGPDGMQ-RENRIKE-LEQEVARSTEVALRLQ 493
TER QL E A + + E +G G++ E+R + LE++ ++ +L+
Sbjct: 313 VKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLR 372
Query: 494 -RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE-DPAQLLRDLQDSLEREAD 551
+ L E + L K V ++ R Q + Q+ +DL + LE
Sbjct: 373 DKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALES 432
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAAST 609
LR Q + A E L + V++D+ + SE ++ + + T
Sbjct: 433 LRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN---HMAANNLRKTAARVEEDNESLLL 666
PS +S SP + D L++ + H ++ R E ++ LL
Sbjct: 493 PSPPRRS-SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA-SQDLLG 550
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
L+K + + S + + +L +T E + + ++ EL +E + L
Sbjct: 551 TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAH 610
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
++ +Q E L+++ ++L + A+ L ++L EE+ ++D
Sbjct: 611 SLQVAQQQAEELRQEREKLQA---------------AQEELRRQRDRLEEEQEDAVQDGA 655
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL-----DASDQQNVDLKRQLQVIE 841
VR++L R E+L + S+ K+ + ++ S D + ++ L E
Sbjct: 656 -RVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
L L A+ LQ KL L +SL DK LDLN + QLE E
Sbjct: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALN--ESLAQDK-LDLN-RLVAQLEEEKSALQ 770
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
+ ++ E + E++ R E ++ + + +
Sbjct: 771 GRQRQAEQEATVAREEQE-RLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHER 829
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK-NAGLSGKEMTAK 1020
L++ + + ++ + + ++ VE LE E + K +AGL+ ++ A
Sbjct: 830 SQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA-VQLVAA 888
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENEN 1080
+ + + E ++L +Q ++A+L+ +LE + + L E
Sbjct: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948
Query: 1081 SNLSNQCKTLTEEMK-NREAQINKL-SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
+ L Q E+ ++E KL A+ + SL+ +
Sbjct: 949 AGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRE 1008
Query: 1139 XXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
Q+ + ++ +++ +LL + + +++ + + + S ++ +
Sbjct: 1009 LEAERAQLQS--QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE--SEKQQAL 1064
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + + ++ +S+E+ +K + Q+R + S L +E+RDL+A
Sbjct: 1065 SLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA-- 1122
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
E AA +++L++ R + D E E+R +
Sbjct: 1123 -----QREEAAAAHAQEVRRLQEQARDLGKQR-DSCLREAE--ELRTQLRLLEDARDGLR 1174
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
EL A+ KL +++ + E +L+ L E S+ + +++
Sbjct: 1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLG--EGAKEREALRRSNEELRSAVKKAESE 1232
Query: 1379 ELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYE 1438
+ L +E K+ + + K+A L+ L+ +E++ + + EL+++
Sbjct: 1233 RISLKLANEDKEQKLALLEEARTAVGKEA--GELRTGLQEVERSRLEARRELQELRRQ-- 1288
Query: 1439 ETVKKLEHSLALEKAEYEELTGKYELLE-------EEHVVTKARL---TVEKEQAQGELL 1488
+K L+ E EL G+ L E E + + RL E + EL
Sbjct: 1289 --MKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQ 1346
Query: 1489 HVQKELSTALGEIKTLQEK-LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNA 1547
Q++L GE +T + + LG+ A TEK ++ ++ L+ +L E A L
Sbjct: 1347 VAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA-RGLELKLEAA--RAEAAELGL 1403
Query: 1548 RLDQRE 1553
RL E
Sbjct: 1404 RLSAAE 1409
Score = 68.5 bits (160), Expect = 2e-10
Identities = 136/703 (19%), Positives = 276/703 (39%), Gaps = 54/703 (7%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTG 314
+ +E + + E L+ + LR++ +R+E+E+ D + R L + G
Sbjct: 614 VAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEG 673
Query: 315 RSS----EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQ 369
+ S E++++++ ++ T + L+ EK + + + + E+ +E S +
Sbjct: 674 KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEAS 733
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
L+ L L E L + D+ + + L +Q R+ QA++ +++ RE ++ ++
Sbjct: 734 LQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQG--RQRQAEQEATVAREEQERLE 791
Query: 430 NCRV--------LSFKLKKTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELE 479
R+ L L+ E+ + LEQ+ HE+ L+ Q R +ELE
Sbjct: 792 ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 851
Query: 480 Q---EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA 536
Q E R E R RE + G L+ + G + + A
Sbjct: 852 QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER------------EGRTLSEEA 899
Query: 537 QLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETV 595
LR +++LE +++ QL E + L K+ +T + T
Sbjct: 900 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQ 959
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
+ +K + A ++ ++ + EE + + + A + +
Sbjct: 960 EKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER-AQLQS 1018
Query: 656 RVEEDNESLL--LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+++ + E LL L+ +K L L E+ + A + L
Sbjct: 1019 QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 1078
Query: 714 LELNEQEATV---LRRKVEELEQDKEALKKQVKELTSKISSV---TKTSAGSNTTARRSL 767
+ AT+ + R+ + + +E + V LTS++ + + +A ++ R L
Sbjct: 1079 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1138
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD 827
+ L ++R L E +E+R +L E + L EL AQ+K + + R +
Sbjct: 1139 QEQARDLGKQRDSCLR-EAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR--EVQR 1195
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL---KNAKSLRSDKALD 884
Q+ +L+R L +E LR + L + +K ++E L+L K K ++A
Sbjct: 1196 QEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART 1255
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
K+ +L L+E E Q+ + + K+ +E T+
Sbjct: 1256 AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTR 1298
Score = 64.5 bits (150), Expect = 4e-09
Identities = 130/638 (20%), Positives = 264/638 (41%), Gaps = 50/638 (7%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKI 347
E + ++K D L R +A ++ GR + + E E+LR E++ Q +
Sbjct: 746 ESLAQDKLD-LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGL 804
Query: 348 R-EIESELETRPSTEAQTRQIEQLRAKLLAA-ETLCEELMDENEDMKKELRDLXXXXXXM 405
+ + + + E Q + R++L L +L +++++ R+ +
Sbjct: 805 EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEAL 864
Query: 406 QDNFREDQA--DEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
+ RE +A E++ L +L + R LS + + + + LE E +++L ++
Sbjct: 865 ERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLE 924
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ ++ E + L +E LR Q+ +A K+ Q E +
Sbjct: 925 ARREQLEAEGQALLLAKETLTGELAGLR-QQIIATQEKASLDKELMAQKLVQAEREAQAS 983
Query: 524 SSLTRGGSQEDPAQLLRDLQDS---LERE-ADLREQLRNAEEET-----ANCKQVNPPTF 574
R +ED +L R+ + + LE E A L+ QL+ +EE A ++++
Sbjct: 984 LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIA 1043
Query: 575 LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHF 634
+Q + ++ + + + ++ K + ++ + L +++ + Q
Sbjct: 1044 ALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQ 1103
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS---RKLSPTPPANKLS- 690
+ ++ + + LR A+ EE + +++++ +AR ++ S A +L
Sbjct: 1104 EQDRSTV--NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRT 1161
Query: 691 ----IETANDNDEKETDEADPA--EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKE 744
+E A D +E EA E + E+ QEA LRR + E +++EAL++ +E
Sbjct: 1162 QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEE 1221
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDEIDEVRKKLIEKERDCER 802
L S + K + + + + KLA EE + E E+R L E ER R
Sbjct: 1222 LRSAV----KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER--SR 1275
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV-LRAKTQSLEADNEKL 861
L A L + + R + D +N L R+L ++ ++ RA+ +S +
Sbjct: 1276 LEARRELQELR-------RQMKMLDSENTRLGRELAELQGRLALGERAEKES------RR 1322
Query: 862 QTENKKLQLLKNAKSLR-SDKALDLNTKKTTQLENELK 898
+T + +LLK SL + L + +K + E E +
Sbjct: 1323 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1360
Score = 60.5 bits (140), Expect = 6e-08
Identities = 147/821 (17%), Positives = 320/821 (38%), Gaps = 68/821 (8%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E L++ + LR ++ E E+ + +LAN D K + + ++ EL T
Sbjct: 1213 EALRRSNEELRSAVKKAESERISL---KLANEDKEQKLALLEEARTA-VGKEAGELRTGL 1268
Query: 334 EDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELMDENEDMK 392
+++ + ++++E+ +++ S + R++ +L+ +L E +E E ++
Sbjct: 1269 QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR 1328
Query: 393 KELRDLXXXXXXMQDNFR------EDQADEYSSLRRELEQTIKNCRVLSFK----LKKTE 442
+ L M+ + ++Q E+ + R L +++ R + + E
Sbjct: 1329 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE 1388
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR--LQRELAEAN 500
K + E AE +L G G++ E E+++ A + LR L+R L
Sbjct: 1389 LKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGR 1448
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTR--------GGSQEDPAQLLRDLQDSLEREADL 552
+ P + + S L G P L+ EA +
Sbjct: 1449 APSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA-V 1507
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
R LR +E + ++ D+ + + + E E +S ++ A +
Sbjct: 1508 RGALREFLQELRSAQRER-----DELRTQTSALNRQLAEMEAERDSATSR---ARQLQKA 1559
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
+S+ S+D Q L S+ + R T +V SL Q +
Sbjct: 1560 VAESEEARRSVDGRLSGVQAELALQEESV--RRSERERRATLDQVATLERSL--QATESE 1615
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV--EE 730
+A K+S AN+ +E ++ D ++ +KL L+ E + R ++ +
Sbjct: 1616 LRASQEKISKMK-ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
E +AL+ +V L +++ ++ AG+ L K+ EE L D++ +
Sbjct: 1675 REAQAQALQDRVDSLQRQVAD-SEVKAGTLQLTVERLNGALAKV-EESEGALRDKVRGLT 1732
Query: 791 KKLIEKERDC-----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ L + + LH + +L + + LDA+ Q + ++Q + ++
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
LR + LE ++++ E + QL + + + +A LNT + Q E L + ++
Sbjct: 1793 TLRGEVADLEL--QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQE--RLG 1848
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
L+ ++EK+ A + E D + ++ + L+S +
Sbjct: 1849 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVE--------------REKLRSHE 1894
Query: 966 DDAQKSF-KPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
D + S K R+ + T +L + ++ ++ LE ++ + A L + +L
Sbjct: 1895 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL 1954
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
++E++ +RS ++ + + + + L++ + L+G
Sbjct: 1955 QQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1995
Score = 55.6 bits (128), Expect = 2e-06
Identities = 119/631 (18%), Positives = 233/631 (36%), Gaps = 49/631 (7%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTES-- 1242
+ +E+QL +D+ + L + + LS E ++ LQ + E
Sbjct: 564 RALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELR 623
Query: 1243 -KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMV 1301
+ L+A +L+ + E + ++LE + RQ + + E+V
Sbjct: 624 QEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELV 683
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXX 1361
E+R Q E L K EA +L M +L+++ A L++
Sbjct: 684 EVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL----- 738
Query: 1362 XXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQ 1421
+K L+ L ++ L+R+ V + E + L+G+ + EQ
Sbjct: 739 -------------SKLSALNESLAQDKLDLNRL-------VAQLEEEKSALQGRQRQAEQ 778
Query: 1422 NSGAG---AKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
+ +R+ EL+ E E + LE SL + + E L + L E + +L
Sbjct: 779 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838
Query: 1479 EKEQAQGELLHVQKELSTALGEIKTLQ------EKLGTESAAWNTEKTEMQNSIASLQER 1532
Q G +++ A +++ L+ E L E A + + +L E
Sbjct: 839 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
Query: 1533 LCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDY-ERVS 1591
+E+ L L + +R+L RR+ LE +++
Sbjct: 899 --ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQII 956
Query: 1592 KIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQV 1651
Q + S + ++A + R + + EL++ Q+
Sbjct: 957 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL 1016
Query: 1652 -SRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
S+ +RE++ LEA ++ ++E + + R+ E E + ++L E +
Sbjct: 1017 QSQLQREQEELLARLEAEKEELSE---EIAALQQERDEGLLLAESEKQQALSLKESEKTA 1073
Query: 1711 LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGL-AT 1768
L ++L +R + ++ E+ +K A+ R + +S +N E R L + R A A
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1133
Query: 1769 RMELAWHKERD---EQQRLLQETSTLARDLR 1796
+ + RD ++ L+E L LR
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLR 1164
Score = 50.0 bits (114), Expect = 8e-05
Identities = 173/830 (20%), Positives = 320/830 (38%), Gaps = 72/830 (8%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEA--QTRQIEQLRAKLLAAET 379
L Q EL + +++ L+ +R ES E +A Q + EQLR K+L +
Sbjct: 321 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD 380
Query: 380 LCEELMD---ENEDMKKELRDLXXXXXXMQ-DNFREDQADEYSSLRRELEQTIKNCRVLS 435
L ++ M + D+ + +L ++ N +DQ ++ L +LE +++ R+
Sbjct: 381 LAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNK--DLTEKLE-ALESLRLQE 437
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
+TE + L+Q + + +L G+Q E + + + L QR
Sbjct: 438 QAALETE-DGEGLQQTLRDLAQAVLS--DSESGVQLSG--SERTADASNGSLRGLSGQRT 492
Query: 496 LAEANSKFTGSNPSLMKVPQP-----ETVKVSRSSL---------TRG---GSQEDPAQL 538
+ G S + P P T+ + S+L RG SQ+ L
Sbjct: 493 PSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTL 552
Query: 539 LRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
+ L DS L EQL+ ++T Q + + Q + E + +S
Sbjct: 553 RKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS-REKSNLAHS 611
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
+Q A +EK + + + + + + ++ + + + R
Sbjct: 612 LQVAQQQAEELRQEREKLQAAQEELRRQRDRLE---EEQEDAVQDGARVRRELERSHRQL 668
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
E E L K + R T + L E A + EA E++L +
Sbjct: 669 EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
Query: 719 QEATVLRRKVEELEQDKEAL---KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E L+ + +L E+L K + L +++ G A + T +
Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE-- 786
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
+ER++ L E + R+ L R E+ A+ +L Q+ P TL RS +Q L R
Sbjct: 787 QERLEELRLEQEVARQGLEGSLRVAEQ--AQEALEQQLP-TLRHERS--QLQEQLAQLSR 841
Query: 836 QLQVIEQEASVLRAKTQ-SLEA------DNEKLQTENKKL--QLLKNAKSLR--SDKALD 884
QL EQE R + Q +EA + E L E+ L QL+ + R S++A
Sbjct: 842 QLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 901
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
L +K LE L E ++ +LE + ++E + KET T +
Sbjct: 902 LRLEKEA-LEGSLFEVQRQLAQLEARREQLEAEGQALL---LAKETLTGELAGLRQQIIA 957
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
Q +++ + +AQ S + + DL +LQ +K E E E
Sbjct: 958 TQEKASLDKELMAQKLVQA-EREAQASLREQRAAHEEDL-QRLQREKEAAWRELE-AERA 1014
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ +E+ A+ + EKE E+ +++ E ++ L E K + ++ K E
Sbjct: 1015 QLQSQLQREQEELLARLEAEKE--ELSEEIAALQQE--RDEGLLLAESEKQQALSLK-ES 1069
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ----INKLSADLKN 1110
+K + K + + +S + + + ++R+ Q +N L+++L++
Sbjct: 1070 EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRD 1119
Score = 48.0 bits (109), Expect = 3e-04
Identities = 102/531 (19%), Positives = 221/531 (41%), Gaps = 50/531 (9%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
Q++ ++LR + L +++ E+E+E R S ++ RQ+++ A+ +E
Sbjct: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAE---RDSATSRARQLQKAVAE---SEEARRS 1569
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ ++ EL L + R D+ ++L R L+ T R K+ K +
Sbjct: 1570 VDGRLSGVQAELA-LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1628
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+LE +K ++L E++ + ++ E + + LE E+ RS L L A+A +
Sbjct: 1629 NETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRS---RLGLSDREAQAQA 1681
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
SL + +V+ S + G Q +L L E E LR+++R E
Sbjct: 1682 -LQDRVDSLQR-------QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1733
Query: 562 ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + DK + +T H+ + + + + AA S+ + S L
Sbjct: 1734 ALAQ-SSASLNSTRDKNLHLQKALTACEHDRQ-----VLQERLDAARQALSEARKQSSSL 1787
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
T + DL + LR+ + +E + L ++K+ + R +
Sbjct: 1788 GEQVQTLRGEV-ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ-- 1844
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
S++ A E E E + + ++L E++ LRR ++++E++K +
Sbjct: 1845 ----ERLGSLQRALAQLEAEKREVERSALRL-----EKDRVALRRTLDKVEREKLRSHED 1895
Query: 742 VKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE 801
L+++ + +T G+ + + E +V VLE + +E + +
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAEA--QRQIQQLEAQVVVLEQSHSPAQ---LEVDAQQQ 1950
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
+L + + + + R+L+A ++ + +++++ +E++ S L+ + Q
Sbjct: 1951 QLELQQEVERLRSAQAQTERTLEARERAH---RQRVRGLEEQVSTLKGQLQ 1998
Score = 46.4 bits (105), Expect = 0.001
Identities = 96/425 (22%), Positives = 168/425 (39%), Gaps = 44/425 (10%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSA 757
+ DP ++ L QE +R+ +EL AL +Q+ E+ ++ S T + +
Sbjct: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 1560
Query: 758 GSNTTARRSLTTNSN------KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ ARRS+ + L EE V+ E E ++ ER + +EL +Q
Sbjct: 1561 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1620
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK----LQTENKK 867
+K + + + D++ LK L E L + +SLE + ++ L +
Sbjct: 1621 EKISKMKANETKLEGDKRR--LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ 1678
Query: 868 LQLLKNAKSLRSDKALDLNTKK-TTQLENE-LKEALAKIKELEMICQDEKSEKKVR-FTE 924
Q L++ + D K T QL E L ALAK++E E +D KVR TE
Sbjct: 1679 AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD-----KVRGLTE 1733
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
A + + +L S + Q L DA + K+ + L
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL-----DAARQALSEARKQSSSLG 1788
Query: 985 TKLQ-LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
++Q L+ V DLE ++ G+ + L ++ E + + +
Sbjct: 1789 EQVQTLRGEVADLE---------LQRVEAEGQLQQLREVL-RQRQEGEAAALNTVQKLQD 1838
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC-KTLTEEMKNREAQIN 1102
E+ LQ + L+ A+LE +K LE + L K E++++ E +
Sbjct: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV- 1897
Query: 1103 KLSAD 1107
+LSA+
Sbjct: 1898 RLSAE 1902
Score = 42.3 bits (95), Expect = 0.017
Identities = 82/412 (19%), Positives = 171/412 (41%), Gaps = 29/412 (7%)
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
D++ + L+ TE+E A++ +++++K++ KLE + E + +
Sbjct: 1600 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1659
Query: 1379 ELDTDLQSERKKL-DR---MRIAHDK--DVKNKDAELATLKGKLKI-LEQNSGAGAKRIT 1431
L+ +LQ R L DR + D+ ++ + A+ G L++ +E+ +GA AK +
Sbjct: 1660 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAK-VE 1718
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK--ARLTVEKEQAQGELLH 1489
E + + V+ L +LA A K L++ + ++ E+ A + L
Sbjct: 1719 ESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALS 1778
Query: 1490 VQKELSTALGE-IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR 1548
++ S++LGE ++TL+ E A ++ E + + L+E L E E A LN
Sbjct: 1779 EARKQSSSLGEQVQTLR----GEVADLELQRVEAEGQLQQLREVL-RQRQEGEAAALNT- 1832
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVS-KIQRXXXXXXXXXXXX 1607
++ D R +L+ + ER + ++++
Sbjct: 1833 -------VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKV 1885
Query: 1608 XXXXXXXIEQSEK--ARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQML 1665
E + + A K + T T E ++ + +++ L QV + + +
Sbjct: 1886 EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEV 1945
Query: 1666 EAAQKSMAEIKNGD--KSARIHRNSISSTDEEEYRNKVALLEQQVACLEDEL 1715
+A Q+ + + + +SA+ E +R +V LE+QV+ L+ +L
Sbjct: 1946 DAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
Score = 33.9 bits (74), Expect = 6.0
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 18/174 (10%)
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSIS---ST 1692
+ + +R + +L+ Q++ ERD+ QK++AE + +S + + +
Sbjct: 1524 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 1583
Query: 1693 DEEEY----RNKVALLEQQVACLEDEL--CESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
EE R + A L+ QVA LE L ES L AS+ E +S+ + E +L + R
Sbjct: 1584 QEESVRRSERERRATLD-QVATLERSLQATESELRASQ---EKISKMKANETKLEGDKRR 1639
Query: 1747 LNEY---EEERL--LSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
L E E R L R + G R L + Q L +L R +
Sbjct: 1640 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1693
>AB007914-1|BAA32290.2| 1919|Homo sapiens KIAA0445 protein protein.
Length = 1919
Score = 77.0 bits (181), Expect = 6e-13
Identities = 239/1266 (18%), Positives = 483/1266 (38%), Gaps = 89/1266 (7%)
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESEL------ETRPSTEAQTRQI--EQLRAKLLAAET 379
+L + +L ++ T+ +++ES L + R ++ AQ + EQL A +
Sbjct: 95 QLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 154
Query: 380 LCEELMDENEDM---KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
L E++ D +KEL +++F ++E+S L Q + R++S
Sbjct: 155 LSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSE 214
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEI-VGGPDGMQ-RENRIKE-LEQEVARSTEVALRLQ 493
TER QL E A + + E +G G++ E+R + LE++ ++ +L+
Sbjct: 215 VKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLR 274
Query: 494 -RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE-DPAQLLRDLQDSLEREAD 551
+ L E + L K V ++ R Q + Q+ +DL + LE
Sbjct: 275 DKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALES 334
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM--IHAAST 609
LR Q + A E L + V++D+ + SE ++ + + T
Sbjct: 335 LRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 394
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN---HMAANNLRKTAARVEEDNESLLL 666
PS +S SP + D L++ + H ++ R E ++ LL
Sbjct: 395 PSPPRRS-SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA-SQDLLG 452
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
L+K + + S + + +L +T E + + ++ EL +E + L
Sbjct: 453 TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAH 512
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
++ +Q E L+++ ++L + A+ L ++L EE+ ++D
Sbjct: 513 SLQVAQQQAEELRQEREKLQA---------------AQEELRRQRDRLEEEQEDAVQDGA 557
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL-----DASDQQNVDLKRQLQVIE 841
VR++L R E+L + S+ K+ + ++ S D + ++ L E
Sbjct: 558 -RVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 616
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
L L A+ LQ KL L +SL DK LDLN + QLE E
Sbjct: 617 AGRVELELSMTKLRAEEASLQDSLSKLSALN--ESLAQDK-LDLN-RLVAQLEEEKSALQ 672
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
+ ++ E + E++ R E ++ + + +
Sbjct: 673 GRQRQAEQEATVAREEQE-RLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHER 731
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK-NAGLSGKEMTAK 1020
L++ + + ++ + + ++ VE LE E + K +AGL+ ++ A
Sbjct: 732 SQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA-VQLVAA 790
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENEN 1080
+ + + E ++L +Q ++A+L+ +LE + + L E
Sbjct: 791 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 850
Query: 1081 SNLSNQCKTLTEEMK-NREAQINKL-SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
+ L Q E+ ++E KL A+ + SL+ +
Sbjct: 851 AGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRE 910
Query: 1139 XXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
Q+ + ++ +++ +LL + + +++ + + + S ++ +
Sbjct: 911 LEAERAQLQS--QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE--SEKQQAL 966
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + + ++ +S+E+ +K + Q+R + S L +E+RDL+A
Sbjct: 967 SLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA-- 1024
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
E AA +++L++ R + D E E+R +
Sbjct: 1025 -----QREEAAAAHAQEVRRLQEQARDLGKQR-DSCLREAE--ELRTQLRLLEDARDGLR 1076
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
EL A+ KL +++ + E +L+ L E S+ + +++
Sbjct: 1077 RELLEAQRKLRESQEGREVQRQEAGELRRSLG--EGAKEREALRRSNEELRSAVKKAESE 1134
Query: 1379 ELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYE 1438
+ L +E K+ + + K+A L+ L+ +E++ + + EL+++
Sbjct: 1135 RISLKLANEDKEQKLALLEEARTAVGKEA--GELRTGLQEVERSRLEARRELQELRRQ-- 1190
Query: 1439 ETVKKLEHSLALEKAEYEELTGKYELLE-------EEHVVTKARL---TVEKEQAQGELL 1488
+K L+ E EL G+ L E E + + RL E + EL
Sbjct: 1191 --MKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQ 1248
Query: 1489 HVQKELSTALGEIKTLQEK-LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNA 1547
Q++L GE +T + + LG+ A TEK ++ ++ L+ +L E A L
Sbjct: 1249 VAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA-RGLELKLEAA--RAEAAELGL 1305
Query: 1548 RLDQRE 1553
RL E
Sbjct: 1306 RLSAAE 1311
Score = 68.5 bits (160), Expect = 2e-10
Identities = 136/703 (19%), Positives = 276/703 (39%), Gaps = 54/703 (7%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTG 314
+ +E + + E L+ + LR++ +R+E+E+ D + R L + G
Sbjct: 516 VAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEG 575
Query: 315 RSS----EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQ 369
+ S E++++++ ++ T + L+ EK + + + + E+ +E S +
Sbjct: 576 KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEAS 635
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
L+ L L E L + D+ + + L +Q R+ QA++ +++ RE ++ ++
Sbjct: 636 LQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQG--RQRQAEQEATVAREEQERLE 693
Query: 430 NCRV--------LSFKLKKTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELE 479
R+ L L+ E+ + LEQ+ HE+ L+ Q R +ELE
Sbjct: 694 ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELE 753
Query: 480 Q---EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA 536
Q E R E R RE + G L+ + G + + A
Sbjct: 754 QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER------------EGRTLSEEA 801
Query: 537 QLLRDLQDSLEREA-DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETV 595
LR +++LE +++ QL E + L K+ +T + T
Sbjct: 802 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQ 861
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
+ +K + A ++ ++ + EE + + + A + +
Sbjct: 862 EKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER-AQLQS 920
Query: 656 RVEEDNESLL--LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+++ + E LL L+ +K L L E+ + A + L
Sbjct: 921 QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 980
Query: 714 LELNEQEATV---LRRKVEELEQDKEALKKQVKELTSKISSV---TKTSAGSNTTARRSL 767
+ AT+ + R+ + + +E + V LTS++ + + +A ++ R L
Sbjct: 981 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1040
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD 827
+ L ++R L E +E+R +L E + L EL AQ+K + + R +
Sbjct: 1041 QEQARDLGKQRDSCLR-EAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR--EVQR 1097
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL---KNAKSLRSDKALD 884
Q+ +L+R L +E LR + L + +K ++E L+L K K ++A
Sbjct: 1098 QEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART 1157
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
K+ +L L+E E Q+ + + K+ +E T+
Sbjct: 1158 AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTR 1200
Score = 64.5 bits (150), Expect = 4e-09
Identities = 130/638 (20%), Positives = 264/638 (41%), Gaps = 50/638 (7%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKI 347
E + ++K D L R +A ++ GR + + E E+LR E++ Q +
Sbjct: 648 ESLAQDKLD-LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGL 706
Query: 348 R-EIESELETRPSTEAQTRQIEQLRAKLLAA-ETLCEELMDENEDMKKELRDLXXXXXXM 405
+ + + + E Q + R++L L +L +++++ R+ +
Sbjct: 707 EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEAL 766
Query: 406 QDNFREDQA--DEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
+ RE +A E++ L +L + R LS + + + + LE E +++L ++
Sbjct: 767 ERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLE 826
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ ++ E + L +E LR Q+ +A K+ Q E +
Sbjct: 827 ARREQLEAEGQALLLAKETLTGELAGLR-QQIIATQEKASLDKELMAQKLVQAEREAQAS 885
Query: 524 SSLTRGGSQEDPAQLLRDLQDS---LERE-ADLREQLRNAEEET-----ANCKQVNPPTF 574
R +ED +L R+ + + LE E A L+ QL+ +EE A ++++
Sbjct: 886 LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIA 945
Query: 575 LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHF 634
+Q + ++ + + + ++ K + ++ + L +++ + Q
Sbjct: 946 ALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQ 1005
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS---RKLSPTPPANKLS- 690
+ ++ + + LR A+ EE + +++++ +AR ++ S A +L
Sbjct: 1006 EQDRSTV--NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRT 1063
Query: 691 ----IETANDNDEKETDEADPA--EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKE 744
+E A D +E EA E + E+ QEA LRR + E +++EAL++ +E
Sbjct: 1064 QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEE 1123
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDEIDEVRKKLIEKERDCER 802
L S + K + + + + KLA EE + E E+R L E ER R
Sbjct: 1124 LRSAV----KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER--SR 1177
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV-LRAKTQSLEADNEKL 861
L A L + + R + D +N L R+L ++ ++ RA+ +S +
Sbjct: 1178 LEARRELQELR-------RQMKMLDSENTRLGRELAELQGRLALGERAEKES------RR 1224
Query: 862 QTENKKLQLLKNAKSLR-SDKALDLNTKKTTQLENELK 898
+T + +LLK SL + L + +K + E E +
Sbjct: 1225 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1262
Score = 60.5 bits (140), Expect = 6e-08
Identities = 147/821 (17%), Positives = 320/821 (38%), Gaps = 68/821 (8%)
Query: 274 EGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHN 333
E L++ + LR ++ E E+ + +LAN D K + + ++ EL T
Sbjct: 1115 EALRRSNEELRSAVKKAESERISL---KLANEDKEQKLALLEEARTA-VGKEAGELRTGL 1170
Query: 334 EDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELMDENEDMK 392
+++ + ++++E+ +++ S + R++ +L+ +L E +E E ++
Sbjct: 1171 QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR 1230
Query: 393 KELRDLXXXXXXMQDNFR------EDQADEYSSLRRELEQTIKNCRVLSFK----LKKTE 442
+ L M+ + ++Q E+ + R L +++ R + + E
Sbjct: 1231 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE 1290
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR--LQRELAEAN 500
K + E AE +L G G++ E E+++ A + LR L+R L
Sbjct: 1291 LKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGR 1350
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTR--------GGSQEDPAQLLRDLQDSLEREADL 552
+ P + + S L G P L+ EA +
Sbjct: 1351 APSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA-V 1409
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
R LR +E + ++ D+ + + + E E +S ++ A +
Sbjct: 1410 RGALREFLQELRSAQRER-----DELRTQTSALNRQLAEMEAERDSATSR---ARQLQKA 1461
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
+S+ S+D Q L S+ + R T +V SL Q +
Sbjct: 1462 VAESEEARRSVDGRLSGVQAELALQEESV--RRSERERRATLDQVATLERSL--QATESE 1517
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV--EE 730
+A K+S AN+ +E ++ D ++ +KL L+ E + R ++ +
Sbjct: 1518 LRASQEKISKMK-ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1576
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
E +AL+ +V L +++ ++ AG+ L K+ EE L D++ +
Sbjct: 1577 REAQAQALQDRVDSLQRQVAD-SEVKAGTLQLTVERLNGALAKV-EESEGALRDKVRGLT 1634
Query: 791 KKLIEKERDC-----ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ L + + LH + +L + + LDA+ Q + ++Q + ++
Sbjct: 1635 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1694
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
LR + LE ++++ E + QL + + + +A LNT + Q E L + ++
Sbjct: 1695 TLRGEVADLEL--QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQE--RLG 1750
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
L+ ++EK+ A + E D + ++ + L+S +
Sbjct: 1751 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVE--------------REKLRSHE 1796
Query: 966 DDAQKSF-KPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
D + S K R+ + T +L + ++ ++ LE ++ + A L + +L
Sbjct: 1797 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL 1856
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
++E++ +RS ++ + + + + L++ + L+G
Sbjct: 1857 QQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1897
Score = 55.6 bits (128), Expect = 2e-06
Identities = 119/631 (18%), Positives = 233/631 (36%), Gaps = 49/631 (7%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTES-- 1242
+ +E+QL +D+ + L + + LS E ++ LQ + E
Sbjct: 466 RALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELR 525
Query: 1243 -KFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMV 1301
+ L+A +L+ + E + ++LE + RQ + + E+V
Sbjct: 526 QEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELV 585
Query: 1302 EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXX 1361
E+R Q E L K EA +L M +L+++ A L++
Sbjct: 586 EVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL----- 640
Query: 1362 XXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQ 1421
+K L+ L ++ L+R+ V + E + L+G+ + EQ
Sbjct: 641 -------------SKLSALNESLAQDKLDLNRL-------VAQLEEEKSALQGRQRQAEQ 680
Query: 1422 NSGAG---AKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
+ +R+ EL+ E E + LE SL + + E L + L E + +L
Sbjct: 681 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 740
Query: 1479 EKEQAQGELLHVQKELSTALGEIKTLQ------EKLGTESAAWNTEKTEMQNSIASLQER 1532
Q G +++ A +++ L+ E L E A + + +L E
Sbjct: 741 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 800
Query: 1533 LCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDY-ERVS 1591
+E+ L L + +R+L RR+ LE +++
Sbjct: 801 --ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQII 858
Query: 1592 KIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQV 1651
Q + S + ++A + R + + EL++ Q+
Sbjct: 859 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL 918
Query: 1652 -SRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
S+ +RE++ LEA ++ ++E + + R+ E E + ++L E +
Sbjct: 919 QSQLQREQEELLARLEAEKEELSE---EIAALQQERDEGLLLAESEKQQALSLKESEKTA 975
Query: 1711 LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE-RLLSSGRARVAGL-AT 1768
L ++L +R + ++ E+ +K A+ R + +S +N E R L + R A A
Sbjct: 976 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1035
Query: 1769 RMELAWHKERD---EQQRLLQETSTLARDLR 1796
+ + RD ++ L+E L LR
Sbjct: 1036 EVRRLQEQARDLGKQRDSCLREAEELRTQLR 1066
Score = 50.0 bits (114), Expect = 8e-05
Identities = 173/830 (20%), Positives = 320/830 (38%), Gaps = 72/830 (8%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEA--QTRQIEQLRAKLLAAET 379
L Q EL + +++ L+ +R ES E +A Q + EQLR K+L +
Sbjct: 223 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD 282
Query: 380 LCEELMD---ENEDMKKELRDLXXXXXXMQ-DNFREDQADEYSSLRRELEQTIKNCRVLS 435
L ++ M + D+ + +L ++ N +DQ ++ L +LE +++ R+
Sbjct: 283 LAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNK--DLTEKLE-ALESLRLQE 339
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
+TE + L+Q + + +L G+Q E + + + L QR
Sbjct: 340 QAALETE-DGEGLQQTLRDLAQAVLS--DSESGVQLSG--SERTADASNGSLRGLSGQRT 394
Query: 496 LAEANSKFTGSNPSLMKVPQP-----ETVKVSRSSL---------TRG---GSQEDPAQL 538
+ G S + P P T+ + S+L RG SQ+ L
Sbjct: 395 PSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTL 454
Query: 539 LRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
+ L DS L EQL+ ++T Q + + Q + E + +S
Sbjct: 455 RKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS-REKSNLAHS 513
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
+Q A +EK + + + + + + ++ + + + R
Sbjct: 514 LQVAQQQAEELRQEREKLQAAQEELRRQRDRLE---EEQEDAVQDGARVRRELERSHRQL 570
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
E E L K + R T + L E A + EA E++L +
Sbjct: 571 EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 630
Query: 719 QEATVLRRKVEELEQDKEAL---KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E L+ + +L E+L K + L +++ G A + T +
Sbjct: 631 AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE-- 688
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
+ER++ L E + R+ L R E+ A+ +L Q+ P TL RS +Q L R
Sbjct: 689 QERLEELRLEQEVARQGLEGSLRVAEQ--AQEALEQQLP-TLRHERS--QLQEQLAQLSR 743
Query: 836 QLQVIEQEASVLRAKTQ-SLEA------DNEKLQTENKKL--QLLKNAKSLR--SDKALD 884
QL EQE R + Q +EA + E L E+ L QL+ + R S++A
Sbjct: 744 QLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 803
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
L +K LE L E ++ +LE + ++E + KET T +
Sbjct: 804 LRLEKEA-LEGSLFEVQRQLAQLEARREQLEAEGQALL---LAKETLTGELAGLRQQIIA 859
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
Q +++ + +AQ S + + DL +LQ +K E E E
Sbjct: 860 TQEKASLDKELMAQKLVQA-EREAQASLREQRAAHEEDL-QRLQREKEAAWRELE-AERA 916
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ +E+ A+ + EKE E+ +++ E ++ L E K + ++ K E
Sbjct: 917 QLQSQLQREQEELLARLEAEKE--ELSEEIAALQQE--RDEGLLLAESEKQQALSLK-ES 971
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ----INKLSADLKN 1110
+K + K + + +S + + + ++R+ Q +N L+++L++
Sbjct: 972 EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRD 1021
Score = 48.0 bits (109), Expect = 3e-04
Identities = 102/531 (19%), Positives = 221/531 (41%), Gaps = 50/531 (9%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
Q++ ++LR + L +++ E+E+E R S ++ RQ+++ A+ +E
Sbjct: 1418 QELRSAQRERDELRTQTSALNRQLAEMEAE---RDSATSRARQLQKAVAE---SEEARRS 1471
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ ++ EL L + R D+ ++L R L+ T R K+ K +
Sbjct: 1472 VDGRLSGVQAELA-LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1530
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+LE +K ++L E++ + ++ E + + LE E+ RS L L A+A +
Sbjct: 1531 NETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRS---RLGLSDREAQAQA 1583
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
SL + +V+ S + G Q +L L E E LR+++R E
Sbjct: 1584 -LQDRVDSLQR-------QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1635
Query: 562 ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + DK + +T H+ + + + + AA S+ + S L
Sbjct: 1636 ALAQ-SSASLNSTRDKNLHLQKALTACEHDRQ-----VLQERLDAARQALSEARKQSSSL 1689
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
T + DL + LR+ + +E + L ++K+ + R +
Sbjct: 1690 GEQVQTLRGEV-ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ-- 1746
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
S++ A E E E + + ++L E++ LRR ++++E++K +
Sbjct: 1747 ----ERLGSLQRALAQLEAEKREVERSALRL-----EKDRVALRRTLDKVEREKLRSHED 1797
Query: 742 VKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE 801
L+++ + +T G+ + + E +V VLE + +E + +
Sbjct: 1798 TVRLSAEKGRLDRTLTGAELELAEA--QRQIQQLEAQVVVLEQSHSPAQ---LEVDAQQQ 1852
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
+L + + + + R+L+A ++ + +++++ +E++ S L+ + Q
Sbjct: 1853 QLELQQEVERLRSAQAQTERTLEARERAH---RQRVRGLEEQVSTLKGQLQ 1900
Score = 46.4 bits (105), Expect = 0.001
Identities = 96/425 (22%), Positives = 168/425 (39%), Gaps = 44/425 (10%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSA 757
+ DP ++ L QE +R+ +EL AL +Q+ E+ ++ S T + +
Sbjct: 1403 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 1462
Query: 758 GSNTTARRSLTTNSN------KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ ARRS+ + L EE V+ E E ++ ER + +EL +Q
Sbjct: 1463 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1522
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK----LQTENKK 867
+K + + + D++ LK L E L + +SLE + ++ L +
Sbjct: 1523 EKISKMKANETKLEGDKRR--LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ 1580
Query: 868 LQLLKNAKSLRSDKALDLNTKK-TTQLENE-LKEALAKIKELEMICQDEKSEKKVR-FTE 924
Q L++ + D K T QL E L ALAK++E E +D KVR TE
Sbjct: 1581 AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD-----KVRGLTE 1635
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
A + + +L S + Q L DA + K+ + L
Sbjct: 1636 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL-----DAARQALSEARKQSSSLG 1690
Query: 985 TKLQ-LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
++Q L+ V DLE ++ G+ + L ++ E + + +
Sbjct: 1691 EQVQTLRGEVADLE---------LQRVEAEGQLQQLREVL-RQRQEGEAAALNTVQKLQD 1740
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC-KTLTEEMKNREAQIN 1102
E+ LQ + L+ A+LE +K LE + L K E++++ E +
Sbjct: 1741 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV- 1799
Query: 1103 KLSAD 1107
+LSA+
Sbjct: 1800 RLSAE 1804
Score = 42.3 bits (95), Expect = 0.017
Identities = 82/412 (19%), Positives = 171/412 (41%), Gaps = 29/412 (7%)
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
D++ + L+ TE+E A++ +++++K++ KLE + E + +
Sbjct: 1502 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1561
Query: 1379 ELDTDLQSERKKL-DR---MRIAHDK--DVKNKDAELATLKGKLKI-LEQNSGAGAKRIT 1431
L+ +LQ R L DR + D+ ++ + A+ G L++ +E+ +GA AK +
Sbjct: 1562 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAK-VE 1620
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTK--ARLTVEKEQAQGELLH 1489
E + + V+ L +LA A K L++ + ++ E+ A + L
Sbjct: 1621 ESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALS 1680
Query: 1490 VQKELSTALGE-IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR 1548
++ S++LGE ++TL+ E A ++ E + + L+E L E E A LN
Sbjct: 1681 EARKQSSSLGEQVQTLR----GEVADLELQRVEAEGQLQQLREVL-RQRQEGEAAALNT- 1734
Query: 1549 LDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVS-KIQRXXXXXXXXXXXX 1607
++ D R +L+ + ER + ++++
Sbjct: 1735 -------VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKV 1787
Query: 1608 XXXXXXXIEQSEK--ARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQML 1665
E + + A K + T T E ++ + +++ L QV + + +
Sbjct: 1788 EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEV 1847
Query: 1666 EAAQKSMAEIKNGD--KSARIHRNSISSTDEEEYRNKVALLEQQVACLEDEL 1715
+A Q+ + + + +SA+ E +R +V LE+QV+ L+ +L
Sbjct: 1848 DAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1899
Score = 33.9 bits (74), Expect = 6.0
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 18/174 (10%)
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSIS---ST 1692
+ + +R + +L+ Q++ ERD+ QK++AE + +S + + +
Sbjct: 1426 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 1485
Query: 1693 DEEEY----RNKVALLEQQVACLEDEL--CESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
EE R + A L+ QVA LE L ES L AS+ E +S+ + E +L + R
Sbjct: 1486 QEESVRRSERERRATLD-QVATLERSLQATESELRASQ---EKISKMKANETKLEGDKRR 1541
Query: 1747 LNEY---EEERL--LSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
L E E R L R + G R L + Q L +L R +
Sbjct: 1542 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1595
>AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein.
Length = 1047
Score = 76.6 bits (180), Expect = 9e-13
Identities = 123/626 (19%), Positives = 266/626 (42%), Gaps = 36/626 (5%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLA 376
EV +LQ+++ + +++++E++ + + E+ S+ + + +Q +E+ +L
Sbjct: 367 EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 426
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
++ E E + E+RDL M D + E +E+ ++ + L
Sbjct: 427 NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQD 486
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
L E + D L K E E L+ + + + +L+++ + ALR E
Sbjct: 487 LLIAKEEQEDLL--RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ-ALRESVEE 543
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
A N + S + + Q T R L QE+ +L ++ R A L+ Q+
Sbjct: 544 ATKNVEVLASRSNTSEQDQAGT--EMRVKLL----QEENEKLQGRSEELERRVAQLQRQI 597
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT--NSIQNKMIHAASTPSSKE 614
+ + + A K+ + + + + +V E E V+ +++N+ + AA S+
Sbjct: 598 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE-LEAAQGNLSQT 656
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
+ LS +K EE++ L L +L KT +++++ +++ + +T
Sbjct: 657 TQEQKQLS-EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD-IVEASRTSTL 714
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-----LELNEQEATVLRRKVE 729
+L N+ + +++T EA+ + + + + L E+E +R +
Sbjct: 715 ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 774
Query: 730 ELEQDKEALKKQVKELTSKI----------SSVTKTSAGSNTTARRSL--TTNSNKLAEE 777
E ++ L++ +K+L ++ S + K + L N++ L E
Sbjct: 775 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 834
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R+ +++++VR +L+++ + L + +++ K L KSR + + +
Sbjct: 835 RISRSREQMEQVRNELLQERAARQDLECDKISLERQNKDL-KSRIIHLEGSYRSSKEGLV 893
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAKSLRSDKALDLNTKKTTQLENE 896
+E + L + +S E D LQ N++L+ +K D+ L L +K QL
Sbjct: 894 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQK-DQLSLR 952
Query: 897 LKEALAKIKEL-EMICQDEKSEKKVR 921
LK +++E E I + E S+KK++
Sbjct: 953 LKAMKRQVEEAEEEIDRLESSKKKLQ 978
Score = 72.1 bits (169), Expect = 2e-11
Identities = 150/777 (19%), Positives = 304/777 (39%), Gaps = 49/777 (6%)
Query: 143 DLDTGQTTNGSQTQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKED 202
++ T T Q + A T DS A+++ ++ + ++ + P + K ++ + ++E
Sbjct: 241 EVKTATATLMLQNRAAATSPDSGAKKI-SVKTFPSASNTQATPDLLKGQQELTQQTNEET 299
Query: 203 EKTARYK-------DERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXX 255
K Y D +TK VN + + K + +G
Sbjct: 300 AKQILYNYLKEGSTDNDDATKRKVNLVFE-KIQTLKSRAAGSAQGNNQACNSTSEVKDLL 358
Query: 256 XXXXXLVDSNVKEYQDQIE-GLKQEVDILRKRCERVEKEKSDILLRRLANID---TANKY 311
L V E Q Q++ +K + +I +R ER+ ++ + ++ T +
Sbjct: 359 EQKSKLT-IEVAELQRQLQLEVKNQQNIKEER-ERMRANLEELRSQHNEKVEENSTLQQR 416
Query: 312 TTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQI---E 368
E+ K +++ ++ E + E + L ++ E+ EL++ +E + + E
Sbjct: 417 LEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEE 476
Query: 369 QLRAK-----LLAAETLCEELMDENED----MKKELRDLXXXXXXMQDNFREDQADEYSS 419
L+AK LL A+ E+L+ + E +K L++ D +E E +
Sbjct: 477 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 536
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-----ENR 474
LR +E+ KN VL+ + +E+ E +++ ++ G + ++R + +
Sbjct: 537 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 596
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
I++L+ + A++ E + + E+ + + + + +G +
Sbjct: 597 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 656
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET 594
Q + L + L+ E++ +EQLR + E N + T Q +IV +
Sbjct: 657 -TQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLE 715
Query: 595 VTNSIQN-KMIHAASTPSSKEKSDSPPLSIDK---TTEETQFHFDLPYLSIFNHMAANNL 650
+ N + K + + + L +K T + Q L + ++ A +
Sbjct: 716 LQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDE 775
Query: 651 RKTAARVEEDNESLL---LQLKKMATKARSRKLSPTPP-ANKLSIETANDNDEKETDEAD 706
T ++ E L L+ K RSR + ++L +E + + +
Sbjct: 776 ALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSER 835
Query: 707 PAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS 766
+ + +E E R ++LE DK +L++Q K+L S+I + GS +++
Sbjct: 836 ISRSREQMEQVRNELLQERAARQDLECDKISLERQNKDLKSRIIHLE----GSYRSSKEG 891
Query: 767 LTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDAS 826
L E LE E + R L R ER EL + Q + L + D
Sbjct: 892 LVVQMEARIAELEDRLESE-ERDRANLQLSNRRLERKVKELVM-QVDDEHLSLTDQKDQL 949
Query: 827 DQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA--KSLRSDK 881
+ +KRQ++ E+E L + + L+ + E+ N+ LQ N+ K LR K
Sbjct: 950 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKK 1006
Score = 70.1 bits (164), Expect = 7e-11
Identities = 132/669 (19%), Positives = 286/669 (42%), Gaps = 62/669 (9%)
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
E + L+R+L+ +KN + + ++ ER LE+ +++H +K+ E + R+
Sbjct: 367 EVAELQRQLQLEVKNQQNIK---EERERMRANLEELRSQHNEKVEE------NSTLQQRL 417
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSS-LTRGGSQED 534
+E E E+ ++ E +++ E + ++ L ++ E RS +G E+
Sbjct: 418 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM-HDELDSAKRSEDREKGALIEE 476
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI---VTCDIHE 591
Q +DLQD L + + + LR E E K D + ++
Sbjct: 477 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 536
Query: 592 -SETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF----HFDLPYLSIFNHMA 646
E+V + +N + A+ + +S++ + + EE + +L
Sbjct: 537 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 596
Query: 647 ANNLRKTAARVEED---NESLLLQLKKMATKARSRKLSPTPPANKLS--IETANDNDEKE 701
+L+ A+ +E E + QL++ AR + L +E A N +
Sbjct: 597 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 656
Query: 702 TDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
T E KL E ++E LRR E+E ++ L K +++L +++ + + S
Sbjct: 657 TQEQKQLSEKLKEESEQKEQ--LRRLKNEMENERWHLGKTIEKLQKEMADIVEAS----- 709
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
R S N+L E + K E+ E++++L EK + E+ Q + + L++
Sbjct: 710 --RTSTLELQNQLDEYKEKNRR-ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMR-LMEEE 765
Query: 822 SLDASDQQNVDL-KRQL--QVIEQEASVLRAKTQSLEADNEKL--QTENKKLQLLKNAKS 876
D Q+ L KRQL Q ++ L AK+ L+ D +L Q E+K QL +
Sbjct: 766 LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSH-LKDDRSRLVKQMEDKVSQLEMELEE 824
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
R++ DL +++ ++ ++++ ++ + QD + +K + +++ LKS+
Sbjct: 825 ERNNS--DLLSERISRSREQMEQVRNELLQERAARQDLECDKI-----SLERQNKDLKSR 877
Query: 937 QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL 996
+A + L+D + + R + + +L++ V++L
Sbjct: 878 --IIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQ----LSNRRLERKVKEL 931
Query: 997 ECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKL 1055
++ + ++ + + +++ + K ++++++E ++ + +S K +LQ E+ +
Sbjct: 932 VMQVDDEHLSLTD---QKDQLSLRLKAMKRQVEEAEEEIDRLESS----KKKLQRELEEQ 984
Query: 1056 KDVNAKLEG 1064
D+N L+G
Sbjct: 985 MDMNEHLQG 993
Score = 58.0 bits (134), Expect = 3e-07
Identities = 120/634 (18%), Positives = 261/634 (41%), Gaps = 45/634 (7%)
Query: 676 RSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLLLELNEQEAT-VLRRKVEELEQ 733
R+ SP A K+S++T + ++ + T + + +L + NE+ A +L ++E
Sbjct: 254 RAAATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGST 313
Query: 734 DKE-ALKKQVKELTSKISSVTKTSAGS---NTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
D + A K++V + KI ++ +AGS N A S T+ L E++ K L E+ E+
Sbjct: 314 DNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS-TSEVKDLLEQKSK-LTIEVAEL 371
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
+++L + ++ + + E + + L + ++N L+++L+ E E
Sbjct: 372 QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKV--EENSTLQQRLEESEGELRKNLE 429
Query: 850 KTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEM 909
+ ++ + E+ QTE + LQ + D A ++ L EL +A +++L +
Sbjct: 430 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL-L 488
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
I ++E+ E +R K+E + K A L++L++ +
Sbjct: 489 IAKEEQ-EDLLR-----KRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE 542
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
++ K + + T Q + E+ + +N L G+ +LE+ + +
Sbjct: 543 EATK-NVEVLASRSNTSEQ-----DQAGTEMRVKLLQEENEKLQGRS----EELERRVAQ 592
Query: 1030 IRSKLS--KNDSEFTNEK-NRLQTEIAKLKD--VNAKLEGDKDVFANKYKALENENSNLS 1084
++ ++ K D E + + EI +L++ V+A+ E + V A + ALENE
Sbjct: 593 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR--ALENELEAAQ 650
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD--CMXXXXXXXXXXXXXXXXXXXX 1142
T+E K ++ + S + L+ M +
Sbjct: 651 GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 710
Query: 1143 XXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXX 1202
++ ++D+ K K +E+ + +++ + +++ ++ ++ +
Sbjct: 711 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 770
Query: 1203 XXXXXXXXQAVVLANTHRRLSIELTSE---KDELQARFIK-TESKFITLEAEMRDLKADY 1258
+ +L T + L EL ++ KD+ ++R +K E K LE E+ + +
Sbjct: 771 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD-RSRLVKQMEDKVSQLEMELEEER--- 826
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
N L I+ ++Q+ + L Q + D
Sbjct: 827 -NNSDLLSERISRSREQMEQVRNELLQERAARQD 859
Score = 55.6 bits (128), Expect = 2e-06
Identities = 108/525 (20%), Positives = 206/525 (39%), Gaps = 36/525 (6%)
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
+QL+ ++ N K + + E+R Q L ++ +L K E
Sbjct: 373 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 432
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
K+E Q ++++ L++ K ++ LQ+++ D +
Sbjct: 433 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED--REKGALIEELLQAKQDLQDLLIA 490
Query: 1397 AHDKD--VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+++ ++ ++ EL LKG LK + + + + +LK++Y+ ++ L S+
Sbjct: 491 KEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQALRESVEEATKN 547
Query: 1455 YEELTGKYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
E L + E++ T+ R L E E+ QG +++ ++ +I+ L+ G E
Sbjct: 548 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK---GDE 604
Query: 1512 SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHD 1571
+ A T K + + I L+E L E E+ ++AR E EL AA
Sbjct: 605 AKAKETLK-KYEGEIRQLEEALVHARKE-EKEAVSAR-RALENELEAAQGNLSQTTQEQK 661
Query: 1572 XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
R+ I ++ + E+ +
Sbjct: 662 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 721
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISS 1691
Y+ + N R EL + Q+ E + K L A K E++ ++ R ++ +
Sbjct: 722 EYK-EKN--RRELAEMQRQLKEKTLEAE--KSRL-TAMKMQDEMRLMEEELRDYQRA--- 772
Query: 1692 TDEEEYRNKVALLEQQVACLEDEL-CESRLL--ASKLNTELVSEKSSAEVRLAEMQSRLN 1748
++E K LLEQ + LE EL +S L S+L ++ + S E+ L E ++ +
Sbjct: 773 --QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNN-S 829
Query: 1749 EYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
+ ER+ R+R R EL +ER +Q L + +L R
Sbjct: 830 DLLSERI---SRSREQMEQVRNELL--QERAARQDLECDKISLER 869
Score = 50.0 bits (114), Expect = 8e-05
Identities = 85/441 (19%), Positives = 179/441 (40%), Gaps = 39/441 (8%)
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIA---HDKDVKNKDAELATLKGKL----KILEQN 1422
+S + + +E + +L+ ++L ++++ H ++++ +L+ + +L + ++
Sbjct: 410 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 469
Query: 1423 SGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQ 1482
GA + + + KQ+ ++ + E L + ELT L+EE + KEQ
Sbjct: 470 KGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 529
Query: 1483 AQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER 1542
EL +++ + A ++ L + T + TEM+ + LQE E
Sbjct: 530 YDAELQALRESVEEATKNVEVLASRSNTSEQ--DQAGTEMR--VKLLQE---------EN 576
Query: 1543 ARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXX 1602
+L R ++ ER R A +R + + D YE +
Sbjct: 577 EKLQGRSEELER--RVAQLQRQIEDLKGD-----EAKAKETLKKYEGEIRQLEEALVHAR 629
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
+E +A + ++ T T+ + Q++ E Q+ R + E +N +
Sbjct: 630 KEEKEAVSARRALENELEAAQGNLSQT-TQEQKQLSEKLKEESEQKEQLRRLKNEMENER 688
Query: 1663 ----QMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES 1718
+ +E QK MA+I +++ + + +E+ R ++A +++Q+ E +S
Sbjct: 689 WHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 748
Query: 1719 RLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKER 1778
RL A K+ E+ E L + Q +E +R L + L +E H +
Sbjct: 749 RLTAMKMQDEM----RLMEEELRDYQRAQDEALTKRQLL--EQTLKDLEYELEAKSHL-K 801
Query: 1779 DEQQRLLQETSTLARDLRQTL 1799
D++ RL+++ L L
Sbjct: 802 DDRSRLVKQMEDKVSQLEMEL 822
>J05211-1|AAA35766.1| 1752|Homo sapiens protein ( Human desmoplakin
mRNA, 3' end. ).
Length = 1752
Score = 76.2 bits (179), Expect = 1e-12
Identities = 166/857 (19%), Positives = 363/857 (42%), Gaps = 92/857 (10%)
Query: 267 KEYQ-DQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
KEY+ +++ L QE ++ E + + ++N+ NKY T + +++
Sbjct: 48 KEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNL--RNKYETEINITKTTIKEI 105
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
+ +++LR++ L+++ R+++ E+ S T Q + L + E+
Sbjct: 106 SMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEI 165
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER- 443
M + + ++ EL+ + +DN R Q+ E E +TI++ K K+ ER
Sbjct: 166 MQKKQHLEIELKQVMQQRS--EDNARHKQSLE------EAAKTIQD------KNKEIERL 211
Query: 444 KADQLEQEKA--EHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELAEA 499
KA+ E+ K E+E +L ++ D + +N+ E E + ++T L +Q+E E
Sbjct: 212 KAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQF-ETEINITKTTIHQLTMQKE--ED 268
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
S + +L + + + ++ R T + E+ ++ D+Q +++ ++ +
Sbjct: 269 TSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQL 328
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
E E Q+ + + D+ ++T+ + +NK I KE +D
Sbjct: 329 EVELRQVTQMRTEESVRYKQSLDDA-------AKTIQD--KNKEIERLKQLIDKETNDRK 379
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRK 679
L D+ + +DL N A + K + E++ L + ++++ + +
Sbjct: 380 CLE-DENARLQRVQYDLQKA---NSSATETINKLKVQ-EQELTRLRIDYERVSQERTVKD 434
Query: 680 LSPTPPANKLS-IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEAL 738
T N L ++ E+E + L+ E + R+K+EE + E +
Sbjct: 435 QDITRFQNSLKELQLQKQKVEEELNR---------LKRTASEDSCKRKKLEE---ELEGM 482
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRS---LTTNSNKL---------AEERVKVLEDEI 786
++ +KE KI+++T+ ++ +RS L + L +E ++ L E+
Sbjct: 483 RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEV 542
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+ +R++L++++ ++ H QK + KSRSL+ S + L+ + + +E +
Sbjct: 543 EALRRQLLQEQESVKQAHLRNEHFQKAIED--KSRSLNESKIEIERLQSLTENLTKEHLM 600
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L + ++L + + L+ + KNA L L ++ +T +L+ + + + +
Sbjct: 601 LEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQREREN 660
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
L + EK +K+ EA+ + ++ K++ +A L+ L+D
Sbjct: 661 LRQ--EIEKFQKQA--LEASNRIQES-KNQCTQVVQERESLLVKIKVLEQDKARLQRLED 715
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
+ ++ K + T+++ + LECE + + + + + K + ++
Sbjct: 716 ELNRA------KSTLEAETRVK-----QRLECEKQQ---IQNDLNQWKTQYSRKEEAIRK 761
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKYKALENENSNLSN 1085
I+ R K + + +E RLQ EI ++++ KLE D LE E S
Sbjct: 762 IESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLE---DSTRETQSQLETERSRYQR 818
Query: 1086 QCKTLTEEM--KNREAQ 1100
+ L + +RE Q
Sbjct: 819 EIDKLRQRPYGSHRETQ 835
Score = 68.9 bits (161), Expect = 2e-10
Identities = 165/845 (19%), Positives = 318/845 (37%), Gaps = 73/845 (8%)
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE 1024
K+D + K R +K KL+ +K +++ E EI + V+++ G T K + E
Sbjct: 17 KNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEG------TRKREYE 70
Query: 1025 KEIDEIRSKLSKNDSEFTNEKNRLQTEI----AKLKDVNAKLEGDKDVFANKYKALENEN 1080
E+ ++R+ ++ E +N +N+ +TEI +K+++ + E D N+ L EN
Sbjct: 71 NELAKVRNHYNE---EMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSREN 127
Query: 1081 SNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXX 1140
+L ++ L + + Q + +NA + S+ M
Sbjct: 128 RDLKDEIVRLNDSILQATEQRRRAE---ENALQQKACGSEIMQKKQHLEIELKQVMQQRS 184
Query: 1141 XXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTX 1200
DN + Q + K + DK K+I E +LS ++
Sbjct: 185 E-----DN-ARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDE 238
Query: 1201 XXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYEN 1260
+ + T +LT +K+E + + ++ L E R L +
Sbjct: 239 EIISLKNQFETEINITKTTIH---QLTMQKEEDTSGY---RAQIDNLTRENRSLSEE--- 289
Query: 1261 KITSLESTIAAKDVHIKQLEDALRQ--TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
I L++T+ +++++E+ ++Q T + + +E VE+R +
Sbjct: 290 -IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLE-VELRQVTQMRTEESVRYK 347
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
L++A ++ E K + + +D LE+ +S A
Sbjct: 348 QSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANS----SAT 403
Query: 1379 ELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYE 1438
E L+ + ++L R+RI +++ + + T+K + QNS K + KQ+ E
Sbjct: 404 ETINKLKVQEQELTRLRIDYERVSQER-----TVKDQDITRFQNS---LKELQLQKQKVE 455
Query: 1439 ETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
E + +L+ + + + K + LEEE + L KEQA ++ ++ ++L A
Sbjct: 456 EELNRLKRTASEDSC-------KRKKLEEELEGMRRSL---KEQAI-KITNLTQQLEQAS 504
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
K ++ L + + E Q + QE L EVE R +L Q + ++
Sbjct: 505 IVKKRSEDDLRQQRDVLDGHLREKQRT----QEELRRLSSEVEALR--RQLLQEQESVKQ 558
Query: 1559 ANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQS 1618
A+ R EH + ER+ + +
Sbjct: 559 AHLRN---EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDL 615
Query: 1619 EKARKAEITD---TKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI 1675
+ R +D T Q+ + L ++ +RER+N +Q +E QK E
Sbjct: 616 RRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEA 675
Query: 1676 KNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSS 1735
N + ++ + + E K+ +LEQ A L+ E S L E K
Sbjct: 676 SNRIQESKNQCTQVVQ-ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE-TRVKQR 733
Query: 1736 AEVRLAEMQSRLNEYEEERLLSSGRAR-VAGLATRMELAWHKERDEQQRLLQETSTLARD 1794
E ++Q+ LN+++ + R + + E + R E +RL E +
Sbjct: 734 LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 793
Query: 1795 LRQTL 1799
R+ L
Sbjct: 794 CRRKL 798
Score = 61.7 bits (143), Expect = 3e-08
Identities = 167/867 (19%), Positives = 340/867 (39%), Gaps = 100/867 (11%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS---VTKTSAGSNTTAR- 764
E++ L L ++E T R EL + + +++ L +K + +TKT+ + +
Sbjct: 51 EIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKE 110
Query: 765 ---RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
++L ++L+ E + L+DEI + +++ +R AE + Q+K S
Sbjct: 111 DDSKNLRNQLDRLSREN-RDLKDEIVRLNDSILQATE--QRRRAEENALQQKA---CGSE 164
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
+ ++LK QV++Q + QSLE + +Q +NK+++ LK
Sbjct: 165 IMQKKQHLEIELK---QVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK--------A 213
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
K+ + ENEL + E E+I + E ++ T+ T + K +
Sbjct: 214 EFQEEAKRRWEYENELSKVRNNYDE-EIISLKNQFETEINITKTTIHQLTMQKEEDTSGY 272
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT-TKLQLKKMVEDLECEI 1000
+A + +L + +S I + LT T L+++ ED++ +
Sbjct: 273 ----------------RAQIDNLTRE-NRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 315
Query: 1001 GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFT-NEKNRLQTEIAKLKDVN 1059
V + E+ T++ E + +R K S +D+ T +KN+ EI +LK +
Sbjct: 316 ATGSEVSQRKQQLEVELRQVTQMRTE-ESVRYKQSLDDAAKTIQDKNK---EIERLKQLI 371
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
K D+ K LE+EN+ L L + + INKL + T L+
Sbjct: 372 DKETNDR-------KCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYE 424
Query: 1120 DCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXX 1179
Q K++++ N+L + + + K
Sbjct: 425 RVSQERTVKDQDITRFQNSLKELQLQKQ---KVEEELNRLKRTASEDSCK---------- 471
Query: 1180 XXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK 1239
K++E++L + + Q + +R +L ++D L +
Sbjct: 472 ----RKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLRE 527
Query: 1240 TESKFITLEAEMRDLKADYEN-KITSLESTIAAKDVHIKQLEDALRQTTNDKYDEAT-SP 1297
+ + E+R L ++ E + L+ + K H++ + ++ DK S
Sbjct: 528 KQ----RTQEELRRLSSEVEALRRQLLQEQESVKQAHLR--NEHFQKAIEDKSRSLNESK 581
Query: 1298 VEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE-----KTEAES--SAAKLEM-AQLK--- 1346
+E+ ++ ++EL N +++ + ++EA+S +A LE+ +QL+
Sbjct: 582 IEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISN 641
Query: 1347 SDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKD 1406
+ +L+ ++ +A E +Q + + ++ + + + K
Sbjct: 642 NRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQV-VQERESLLVKI 700
Query: 1407 AELATLKGKLKILEQNSGAGAKRI---TELKQEYEETVKKLEHSLALEKAEY---EELTG 1460
L K +L+ LE + T +KQ E +++++ L K +Y EE
Sbjct: 701 KVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIR 760
Query: 1461 KYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE-IKTLQEKLGTESAAWNTEK 1519
K E E+ K L E E+ Q E+ +++ L + + Q +L TE + + E
Sbjct: 761 KIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI 820
Query: 1520 TEM-QNSIASLQERLCGGGWEVERARL 1545
++ Q S +E W V+ ++L
Sbjct: 821 DKLRQRPYGSHRETQTECEWTVDTSKL 847
>AK025690-1|BAB15219.1| 746|Homo sapiens protein ( Homo sapiens
cDNA: FLJ22037 fis, clone HEP08868. ).
Length = 746
Score = 76.2 bits (179), Expect = 1e-12
Identities = 125/636 (19%), Positives = 269/636 (42%), Gaps = 41/636 (6%)
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+L + ++ E+ E+LR + + +++ ELE + +T +Q + L +L A +
Sbjct: 31 LLNVARQEEEMKAKEEELRKAMAQTQELVNKVK-ELEEKTATLSQEKN--DLTIQLQAEQ 87
Query: 379 TLCEELMDENED---MKKELRDLXXXXXXMQDNFREDQ--ADEYSSLRRELEQTIKNCRV 433
E LMD E M K DL M++ E++ A S+ +R+LE + + +
Sbjct: 88 ---ENLMDAEERLTWMMKTKMDLESQISDMRERLEEEEGMAASLSAAKRKLEGELSDLKR 144
Query: 434 ----LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENR-IKELEQEVARSTEV 488
L L KTE++ L+ + L +Q+E R ++EL Q+ +
Sbjct: 145 DLEGLETTLAKTEKEKQALDHKVRTLTGDLSLREDSITKLQKEKRALEELHQKTLDDLQA 204
Query: 489 ALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
L + NSK + L + E + R ++ D + +L +
Sbjct: 205 EEDKVNHLTKNNSKLSTQIHELEDNWEQEKKIRAEVEKARRKAESDLKMTIDNLNEMERS 264
Query: 549 EADLREQL--RNAEEETANCKQVNPPTF---LDKQVMTDNIVTCDIHESETVTNSI---- 599
+ DL E + R+ E + N K + + L +++ ++ E ++
Sbjct: 265 KLDLEEVVKKRDLEINSVNSKYEDEQSLNSTLQRKLKEHQDRIEELEEELEAERAMRAKI 324
Query: 600 -QNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
QN+ A +E ++ S + + H D + H+ +L++ +++E
Sbjct: 325 EQNRKREAELLKLRRELEEAALQSEATASTLRKKHVD-SMAELTEHV--ESLQRVKSKLE 381
Query: 659 EDNESLLLQLKKMATKARS---RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLE 715
+D + + ++ + + K++ KL + N + E + AE+ +
Sbjct: 382 KDKQVMKAEIDDLNASMETIQKSKMNAEAHVRKLEDSLSEANAKVAELERNQAEINAIRT 441
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
+ E + L R+ EE + + + LTS++ + + + ++ + +N
Sbjct: 442 RLQAENSELSREYEESQSRLNQILRIKTSLTSQVDDYKRQLDEESKSRSTAVVSLAN--T 499
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
+ + +++++++E + E +R +L+ E++ + K +T R+ + + + L
Sbjct: 500 KHDLDLVKEQLEEEQGGKSELQRLVSKLNTEVTTWRTKYETDAIQRTEELEETKR-KLAA 558
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLE 894
+LQ E+ A +A+ SLE + ++LQ E + L + L+ A + + ALD KK +
Sbjct: 559 RLQEAEEAAETAQARAASLEKNKQRLQAEVEDLTIDLEKANAAAA--ALD---KKQRLFD 613
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
L E K +EL++ + E ++ TE+ K +T
Sbjct: 614 KMLAEWQQKCEELQVEVDSSQKECRMYMTESFKIKT 649
Score = 58.8 bits (136), Expect = 2e-07
Identities = 92/421 (21%), Positives = 178/421 (42%), Gaps = 39/421 (9%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQ---DKEALKKQVKELTSKISSVTKTSAGSNTTARR 765
++K LL + QE ++ K EEL + + L +VKEL K +++++ ++ T +
Sbjct: 27 KVKPLLNVARQEEE-MKAKEEELRKAMAQTQELVNKVKELEEKTATLSQEK--NDLTIQL 83
Query: 766 SLTTNSNKLAEERV------KV-LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
+ AEER+ K+ LE +I ++R++L E+E + A LS A++K + +
Sbjct: 84 QAEQENLMDAEERLTWMMKTKMDLESQISDMRERLEEEEG----MAASLSAAKRKLEGEL 139
Query: 819 KS--RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
R L+ + +++ Q ++ + L E KLQ E + L+ L + K+
Sbjct: 140 SDLKRDLEGLETTLAKTEKEKQALDHKVRTLTGDLSLREDSITKLQKEKRALEEL-HQKT 198
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVR--FTEATKKETDTLK 934
L L K L + +I ELE + + EKK+R +A +K LK
Sbjct: 199 LDD---LQAEEDKVNHLTKNNSKLSTQIHELE---DNWEQEKKIRAEVEKARRKAESDLK 252
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSL--KDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
+ S+ K + ++S + +K + +++ ++
Sbjct: 253 MTIDNLNEMERSKLDLEEVVKKRDLEINSVNSKYEDEQSLNSTLQRKLKEHQDRIE--EL 310
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI 1052
E+LE E + +N + + + +LE+ + + S + + L +
Sbjct: 311 EEELEAERAMRAKIEQNRKREAELLKLRRELEEAALQSEATASTLRKKHVDSMAELTEHV 370
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
L+ V +KLE DK V ++ E +L+ +T+ + N EA + KL L A
Sbjct: 371 ESLQRVKSKLEKDKQV-------MKAEIDDLNASMETIQKSKMNAEAHVRKLEDSLSEAN 423
Query: 1113 S 1113
+
Sbjct: 424 A 424
Score = 58.0 bits (134), Expect = 3e-07
Identities = 101/564 (17%), Positives = 221/564 (39%), Gaps = 37/564 (6%)
Query: 1015 KEMTAKT--KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANK 1072
+E+ KT L+ E D++ + L+KN+S+ + + + L+ + K + A++E + +
Sbjct: 192 EELHQKTLDDLQAEEDKV-NHLTKNNSKLSTQIHELEDNWEQEKKIRAEVEKARRKAESD 250
Query: 1073 YKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXX 1132
K + + + L E +K R+ +IN +++ ++ SL +T+ +
Sbjct: 251 LKMTIDNLNEMERSKLDLEEVVKKRDLEINSVNSKYEDEQSLNSTLQRKLKEHQDRIEEL 310
Query: 1133 XXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKT-----------KKIGDXXXXXXXXX 1181
+++ K + + KL +E+ + KK D
Sbjct: 311 EEELEAERAMRAKIEQNRKREAELLKLRRELEEAALQSEATASTLRKKHVDSMAELTEHV 370
Query: 1182 XXCKRIEKQLSTRKDRVTXXXX---XXXXXXXQAVVLANTHRRLSIELTSEKDELQARFI 1238
+R++ +L K + ++ + A H R + SE + A
Sbjct: 371 ESLQRVKSKLEKDKQVMKAEIDDLNASMETIQKSKMNAEAHVRKLEDSLSEANAKVAELE 430
Query: 1239 KTESKF----ITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEA 1294
+ +++ L+AE +L +YE + L + K Q++D RQ + +
Sbjct: 431 RNQAEINAIRTRLQAENSELSREYEESQSRLNQILRIKTSLTSQVDDYKRQLDEESKSRS 490
Query: 1295 TSPVEMVEMRXXXXXXXXXXXXXQ---DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK 1351
T+ V + + Q EL KL TE + K E ++ +
Sbjct: 491 TAVVSLANTKHDLDLVKEQLEEEQGGKSELQRLVSKL-NTEVTTWRTKYETDAIQR-TEE 548
Query: 1352 LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELAT 1411
LE + + +A L+ + Q + +++ + I D++ +A A
Sbjct: 549 LEETKRKLAARLQEAEEAAETAQARAASLEKNKQRLQAEVEDLTI----DLEKANAAAAA 604
Query: 1412 LKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVV 1471
L K ++ ++ ++ EL+ E + + K+ + ++ T E LE V
Sbjct: 605 LDKKQRLFDKMLAEWQQKCEELQVEVDSSQKECRMYMT---ESFKIKTAYEESLEHLESV 661
Query: 1472 TKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQE 1531
K T+++E +L+ E ++ E++ L++KL E E ++S+ +
Sbjct: 662 KKENKTLQEEIK--DLIDQLGEGGRSVHELQKLKKKLEMEKEELQVALEEAESSLEVEES 719
Query: 1532 RLCGGGWEVERARLNARLDQRERE 1555
++ ++E A++ A +D+R E
Sbjct: 720 KVI--RIQLELAQVKADIDRRIHE 741
Score = 54.8 bits (126), Expect = 3e-06
Identities = 108/559 (19%), Positives = 226/559 (40%), Gaps = 57/559 (10%)
Query: 196 LSKSKEDEKTARYKDERSSTKDDVNFLMQVKN----SRNSTNLKPPVRGGPXXXXXXXXX 251
L + E EK R + E++ K + + M + N R+ +L+ V+
Sbjct: 226 LEDNWEQEKKIRAEVEKARRKAESDLKMTIDNLNEMERSKLDLEEVVKKRDLEINSVNSK 285
Query: 252 XXXXXXXXXLVDSNVKEYQDQIEGLKQEVD---ILRKRCERVEKEKSDILLRRLANIDTA 308
+ +KE+QD+IE L++E++ +R + E+ K ++++L R + A
Sbjct: 286 YEDEQSLNSTLQRKLKEHQDRIEELEEELEAERAMRAKIEQNRKREAELLKLRRELEEAA 345
Query: 309 NKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIE 368
+ S+ K + ELT H E L+ K L + + +++E++ ++ +E
Sbjct: 346 LQSEATASTLRKKHVDSMAELTEHVESLQRVKSKLEKDKQVMKAEIDDLNAS------ME 399
Query: 369 QLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTI 428
++ + AE +L D + ++ +L + + R E S L RE E++
Sbjct: 400 TIQKSKMNAEAHVRKLEDSLSEANAKVAELERNQAEI-NAIRTRLQAENSELSREYEESQ 458
Query: 429 KNC-RVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKE-LEQEVARST 486
++L K T + D Q E + + +V + + +KE LE+E +
Sbjct: 459 SRLNQILRIKTSLTSQVDDYKRQLDEESKSRSTAVVSLANTKHDLDLVKEQLEEEQGGKS 518
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSL 546
E LQR +++ N++ T R + D Q +L+
Sbjct: 519 E----LQRLVSKLNTEVT---------------------TWRTKYETDAIQRTEELE--- 550
Query: 547 EREADLREQLRNAEE--ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM- 603
E + L +L+ AEE ETA + + + +T D+ ++ ++ K
Sbjct: 551 ETKRKLAARLQEAEEAAETAQARAASLEKNKQRLQAEVEDLTIDLEKANAAAAALDKKQR 610
Query: 604 IHAASTPSSKEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFNHMAANNLRKTAARV 657
+ ++K + + +D + +E + F Y H+ +++K +
Sbjct: 611 LFDKMLAEWQQKCEELQVEVDSSQKECRMYMTESFKIKTAYEESLEHL--ESVKKENKTL 668
Query: 658 EEDNESLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
+E+ + L+ QL + +KL K ++ A + E + + +++ LEL
Sbjct: 669 QEEIKDLIDQLGEGGRSVHELQKLKKKLEMEKEELQVALEEAESSLEVEESKVIRIQLEL 728
Query: 717 NEQEATVLRRKVEELEQDK 735
+ +A + RR + E ++ K
Sbjct: 729 AQVKADIDRR-IHEKKKKK 746
Score = 45.6 bits (103), Expect = 0.002
Identities = 100/600 (16%), Positives = 232/600 (38%), Gaps = 46/600 (7%)
Query: 1221 RLSIELTSEKDELQARFIKTESKFITLEAEMRDLK---ADYENKITSLESTIAAKDVHIK 1277
+ ++L S+ +++ R + E +L A R L+ +D + + LE+T+A + +
Sbjct: 102 KTKMDLESQISDMRERLEEEEGMAASLSAAKRKLEGELSDLKRDLEGLETTLAKTEKEKQ 161
Query: 1278 QLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK-LEKTEAESS 1336
L+ +R T D + +R +EL+ + L+ E + +
Sbjct: 162 ALDHKVRTLTGD-----------LSLREDSITKLQKEKRALEELHQKTLDDLQAEEDKVN 210
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK-ELDTDLQSERKKLDRMR 1395
++L + + +LE+ E+ K +D + ER KLD
Sbjct: 211 HLTKNNSKLSTQIHELEDNWEQEKKIRAEVEKARRKAESDLKMTIDNLNEMERSKLDLEE 270
Query: 1396 IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEY 1455
+ VK +D E+ ++ K + + + +++ E + EE ++LE A+
Sbjct: 271 V-----VKKRDLEINSVNSKYEDEQSLNSTLQRKLKEHQDRIEELEEELEAERAMRAKIE 325
Query: 1456 EELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQK--ELSTALGEIKTLQEKLGTESA 1513
+ + ELL+ + +A L E + HV EL+ + ++ ++ KL +
Sbjct: 326 QNRKREAELLKLRRELEEAALQSEATASTLRKKHVDSMAELTEHVESLQRVKSKLEKDKQ 385
Query: 1514 AWNTEKTEMQNSIASLQERLCGGGWEVER-----ARLNARLDQRERELRAANDRRDVLEH 1568
E ++ S+ ++Q+ V + + NA++ + ER N R L+
Sbjct: 386 VMKAEIDDLNASMETIQKSKMNAEAHVRKLEDSLSEANAKVAELERNQAEINAIRTRLQA 445
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITD 1628
+ R+ S K ++
Sbjct: 446 ENSELSREYEESQSRLNQILRIKTSLTSQVDDYKRQLDEESKSRSTAVVSLANTKHDLDL 505
Query: 1629 TKTRYE---GQMNTMRDELKSLHNQVSRFRRERD-----NYKQMLEAAQKSMAEIKNGDK 1680
K + E G + ++ + L+ +V+ +R + + +++ E +K A ++ ++
Sbjct: 506 VKEQLEEEQGGKSELQRLVSKLNTEVTTWRTKYETDAIQRTEELEETKRKLAARLQEAEE 565
Query: 1681 SARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRL 1740
+A + +S ++ + R L+ +V L +L ++ A+ L+ ++ + L
Sbjct: 566 AAETAQARAASLEKNKQR-----LQAEVEDLTIDLEKANAAAAALD----KKQRLFDKML 616
Query: 1741 AEMQSRLNEYEEERLLSSGRARVAGLAT-RMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
AE Q + E + E S R+ + +++ A+ + + + + +E TL +++ +
Sbjct: 617 AEWQQKCEELQVEVDSSQKECRMYMTESFKIKTAYEESLEHLESVKKENKTLQEEIKDLI 676
Score = 41.1 bits (92), Expect = 0.039
Identities = 66/352 (18%), Positives = 144/352 (40%), Gaps = 30/352 (8%)
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVV---TKARLTVEKEQAQGELLHVQKEL 1494
EE +K E L A+ +EL K + LEE+ K LT++ + Q L+ ++ L
Sbjct: 38 EEEMKAKEEELRKAMAQTQELVNKVKELEEKTATLSQEKNDLTIQLQAEQENLMDAEERL 97
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
+ + L+ ++ ++ E+ M S+++ + +L E E + L L+ E
Sbjct: 98 TWMMKTKMDLESQI-SDMRERLEEEEGMAASLSAAKRKL-----EGELSDLKRDLEGLET 151
Query: 1555 ELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXX 1614
L + L+H + ++K+Q+
Sbjct: 152 TLAKTEKEKQALDH------KVRTLTGDLSLREDSITKLQKEKRALEELHQKTLDDL--- 202
Query: 1615 IEQSEKARKAEITDTKTRYEGQMNTMRD---ELKSLHNQVSRFRRERDNYKQM----LEA 1667
Q+E+ + +T ++ Q++ + D + K + +V + RR+ ++ +M L
Sbjct: 203 --QAEEDKVNHLTKNNSKLSTQIHELEDNWEQEKKIRAEVEKARRKAESDLKMTIDNLNE 260
Query: 1668 AQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLED--ELCESRLLASKL 1725
++S +++ K + NS++S E+E ++ + L++++ +D E E L A +
Sbjct: 261 MERSKLDLEEVVKKRDLEINSVNSKYEDE-QSLNSTLQRKLKEHQDRIEELEEELEAERA 319
Query: 1726 NTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKE 1777
+ + E L +++ L E + ++ R + + EL H E
Sbjct: 320 MRAKIEQNRKREAELLKLRRELEEAALQSEATASTLRKKHVDSMAELTEHVE 371
Score = 37.9 bits (84), Expect = 0.37
Identities = 46/244 (18%), Positives = 94/244 (38%), Gaps = 8/244 (3%)
Query: 157 LAITKNDSLAERVRKMQLLKTQNSFEKEPSIEKER-ERRSLSKSKEDEKTARYKDERSST 215
L + K E+ K +L + + E + + + E ++ +++E E+T R R
Sbjct: 503 LDLVKEQLEEEQGGKSELQRLVSKLNTEVTTWRTKYETDAIQRTEELEETKRKLAARLQE 562
Query: 216 KDDVNFLMQVKNS---RNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQ 272
++ Q + + +N L+ V L D + E+Q +
Sbjct: 563 AEEAAETAQARAASLEKNKQRLQAEVEDLTIDLEKANAAAAALDKKQRLFDKMLAEWQQK 622
Query: 273 IEGLKQEVDILRKRCERVEKEKSDILL---RRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
E L+ EVD +K C E I L ++++ K E+ L ++ E
Sbjct: 623 CEELQVEVDSSQKECRMYMTESFKIKTAYEESLEHLESVKKENKTLQEEIKDLIDQLGEG 682
Query: 330 TTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDEN 388
+L+ KK L + E++ L E S E + ++ +++ +L + + + E
Sbjct: 683 GRSVHELQKLKKKLEMEKEELQVALEEAESSLEVEESKVIRIQLELAQVKADIDRRIHEK 742
Query: 389 EDMK 392
+ K
Sbjct: 743 KKKK 746
>AB015617-1|BAA88763.1| 948|Homo sapiens ELKS protein.
Length = 948
Score = 76.2 bits (179), Expect = 1e-12
Identities = 169/820 (20%), Positives = 354/820 (43%), Gaps = 76/820 (9%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL 374
R + ++ LQ ++ E+ N+ LR + + K+ + ++T S E + + LR
Sbjct: 147 RDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA--LRKDE 204
Query: 375 LAAETLCEE----LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL--EQTI 428
+ T+ +E + +EN+ M+ ++ L +D + Q D S E T
Sbjct: 205 ASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE 264
Query: 429 KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEV----- 482
+N + L + ER+A +L + E+ L I + R+ IK+L + +
Sbjct: 265 ENFQRLH---AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 321
Query: 483 -ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD 541
A++TE R LAEA SL++ + E + R + D A+ +
Sbjct: 322 SAKATEEDHERTRRLAEAEMHVHHLE-SLLEQKEKENSMLREEMHRRFENAPDSAKT-KA 379
Query: 542 LQDSLERE----ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LQ +E + + + LR+ EEE K L + + + +++ S +
Sbjct: 380 LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA---LSTEEREEEMKQMEVYRSHS--K 434
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
++NK I S++ ++ L T QF ++ + ++ AA +
Sbjct: 435 FMKNK-IGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR-AAIL 492
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELN 717
+ + ++L L+L++ T NK + + + +EK T + ++K +L++
Sbjct: 493 QTEVDALRLRLEEKETML-----------NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 541
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE- 776
E++ VL++K+E L++ +KQ+ L ++ S+ + ++T +LTT LAE
Sbjct: 542 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT----ALTTLEEALAEK 597
Query: 777 ----ERVKVLEDEIDEVRKKLIEK-ERDCERLHAELSLAQ----KKPKTLIKSRSLDASD 827
ER+K D + +++ I+ ++D + L ++SL Q +K +L+ + AS
Sbjct: 598 ERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE-HASS 656
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
+ LK+ ++ E ++ + K + L+ +++ + L+ A SD+ L
Sbjct: 657 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE--ARASPEMSDRIQHLE- 713
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++ T+ ++E +A A++ L I ++ ++EK + + E ++L S+Q
Sbjct: 714 REITRYKDESSKAQAEVDRLLEILKEVENEKNDK--DKKIAELESLTSRQVKDQNKKVAN 771
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVM 1007
++ + ++A+ R D + +LQ+++++ +E ++ + M
Sbjct: 772 LKHKEQVEKKKSA--QMLEEAR-----RREDNLNDSSQQLQVEELLMAME-KVKQELESM 823
Query: 1008 KNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKD 1067
K A LS + + K E + +R++ K+ E K KD N L +
Sbjct: 824 K-AKLSSTQQSLAEK-ETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL---LE 878
Query: 1068 VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ ++K K E E + L + L +++K + KL AD
Sbjct: 879 LSSSKKKTQE-EVAALKREKDRLVQQLKQQTQNRMKLMAD 917
Score = 53.2 bits (122), Expect = 9e-06
Identities = 143/789 (18%), Positives = 298/789 (37%), Gaps = 90/789 (11%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKT-----LIKSRSLDASDQQNVDL-KR 835
L+ ++ EV ++ +D E ++LS + KT L K R+L + + + K
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK--ALDLNTKKTTQL 893
Q +V+++E ++ Q+L+ ++L+ + QL + S R+ + +L + +L
Sbjct: 214 QYRVVQEENQHMQMTIQALQ---DELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
Query: 894 ----ENELKEA--LAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
E + KE L K ++E+E+ + +K R E+ KK + L+SK
Sbjct: 271 HAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEMLQSKGLSAKATEED 329
Query: 947 XXXXXXXXXXXQAT--LKSLKDDAQKS-------FKPRIPKKPTDLTTKLQLKKMVEDLE 997
L+SL + +K R P TK L+ ++E +
Sbjct: 330 HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA-LQTVIEMKD 388
Query: 998 CEIG-----------EMYVVMKNAGLSGKEMTAKTK-----------LEKEIDEIRSKLS 1035
+I E+ ++ N LS +E + K ++ +I +++ +LS
Sbjct: 389 SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELS 448
Query: 1036 KNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+ D+E + +L+T + D +E V A E + L + L ++
Sbjct: 449 RKDTELLALQTKLETLTNQFSDSKQHIE----VLKESLTAKEQRAAILQTEVDALRLRLE 504
Query: 1096 NREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQD 1155
+E +NK + +++ + T + +++N + +D
Sbjct: 505 EKETMLNKKTKQIQDMAEEKGTQA---GEIHDLKDMLDVKERKVNVLQKKIENLQEQLRD 561
Query: 1156 KNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVL 1215
K K + + ++ K + +E+ L+ ++ + +
Sbjct: 562 KEKQMSSLKERVKSL---QADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 618
Query: 1216 ANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVH 1275
+ +++ + +L+ + + EA + DLK +SL S+ KD
Sbjct: 619 IDNYKK-------DLKDLKEKVSLLQGDLSEKEASLLDLK----EHASSLASSGLKKDSR 667
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
+K LE AL Q K +E ++ D + + + ++ + + ES
Sbjct: 668 LKTLEIALEQ----KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDES 723
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
S A+ E+ +L L ++EN +S ++ + KK+ ++
Sbjct: 724 SKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTS----------RQVKDQNKKVANLK 773
Query: 1396 IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEY 1455
H + V+ K + + + + N + ++ EL E+ ++LE A +
Sbjct: 774 --HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQVEELLMAMEKVKQELESMKAKLSSTQ 831
Query: 1456 EELTGKYELLEEEHVVTKARLTVEKEQAQGELLHV--QKELSTALGEIKTLQEKLGTESA 1513
+ L K L + L E Q LL +K+ + AL E+ + ++K E A
Sbjct: 832 QSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA 891
Query: 1514 AWNTEKTEM 1522
A EK +
Sbjct: 892 ALKREKDRL 900
Score = 50.0 bits (114), Expect = 8e-05
Identities = 97/574 (16%), Positives = 226/574 (39%), Gaps = 35/574 (6%)
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKD 1273
+L T + + + ++K L AR + L+++ KA E+ + +A +
Sbjct: 283 LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR--LAEAE 340
Query: 1274 VHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+H+ LE L Q K E + E + R Q + K+ E
Sbjct: 341 MHVHHLESLLEQ----KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER 396
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+ E+ LKS+ A S + +NK ++ +L + +L
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTEL-- 454
Query: 1394 MRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS---LAL 1450
+A ++ + + K +++L+++ A +R L+ E + +LE L
Sbjct: 455 --LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 512
Query: 1451 EKAEYEELTGKYELLEEEHVVTKARLTVEKEQA---QGELLHVQKELSTALGEIKTLQEK 1507
+ + +++ + E K L V++ + Q ++ ++Q++L ++ +L+E+
Sbjct: 513 KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 572
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+ + A + T ++ +L+E L +ER + D+RE++ N ++D+ +
Sbjct: 573 VKSLQA----DTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 628
Query: 1568 HHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEIT 1627
+ ++ E+ K E +
Sbjct: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME-S 687
Query: 1628 DTKTRYEGQMNT-----MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN--GDK 1680
K +E + M D ++ L +++R++ E + ++ + + E++N DK
Sbjct: 688 QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK 747
Query: 1681 SARI-HRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVR 1739
+I S++S ++ KVA L+ + ++ +++L E SS +++
Sbjct: 748 DKKIAELESLTSRQVKDQNKKVANLKHKEQV--EKKKSAQMLEEARRREDNLNDSSQQLQ 805
Query: 1740 LAEMQSRLNEYEEERLLSSGRARVAGLATRMELA 1773
+ E+ + + ++E L S +A+++ +T+ LA
Sbjct: 806 VEELLMAMEKVKQE--LESMKAKLS--STQQSLA 835
Score = 50.0 bits (114), Expect = 8e-05
Identities = 103/573 (17%), Positives = 219/573 (38%), Gaps = 38/573 (6%)
Query: 1241 ESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND----KYDEATS 1296
E+ + E R A K +L++ I KD I +E LR + K + A S
Sbjct: 356 ENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALS 415
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXX 1356
E E ++++ K +L + + E A + ++ L + + +
Sbjct: 416 TEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI 475
Query: 1357 XXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM--RIAHDKDVKNKDA-ELATLK 1413
++ + + L L+ + L++ +I + K A E+ LK
Sbjct: 476 EVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK 535
Query: 1414 GKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLE--EEHVV 1471
L + E+ K+I L+++ + K++ K+ + T L EE +
Sbjct: 536 DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA 595
Query: 1472 TKARLTVE--KEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASL 1529
K R T+E KEQ + Q+E+ ++K L+EK+ + + +E + S+ L
Sbjct: 596 EKER-TIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV----SLLQGDLSEKEASLLDL 650
Query: 1530 QERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYER 1589
+E + ++RL E L + +E +R
Sbjct: 651 KEH--ASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 708
Query: 1590 VSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR---DELKS 1646
+ ++R +E ++ + K E + T R D+ K
Sbjct: 709 IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKK 768
Query: 1647 LHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQ 1706
+ N + + E+ QMLE A++ + + + ++ EE + ++Q
Sbjct: 769 VANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQV----------EELLMAMEKVKQ 818
Query: 1707 QVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGL 1766
++ ++ +L ++ ++ T L + ++ L E+ E ++E LL++ + A +
Sbjct: 819 ELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVL----EMKQEALLAAISEKDANI 874
Query: 1767 ATRMELAWHKERDEQQ--RLLQETSTLARDLRQ 1797
A +EL+ K++ +++ L +E L + L+Q
Sbjct: 875 AL-LELSSSKKKTQEEVAALKREKDRLVQQLKQ 906
Score = 38.7 bits (86), Expect = 0.21
Identities = 62/257 (24%), Positives = 117/257 (45%), Gaps = 30/257 (11%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ + Y+D+ + EVD L + + VE EK+D +++A +++ S +V
Sbjct: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKND-KDKKIAELESLT------SRQVKD 764
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
+KV L H E + EKK Q + E E + +Q Q+E+L L+A E +
Sbjct: 765 QNKKVANL-KHKEQV--EKKKSAQMLEEARRR-EDNLNDSSQQLQVEEL---LMAMEKVK 817
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
+EL E MK +L + + +A+ R+ LE+ ++ + + +
Sbjct: 818 QEL----ESMKAKLSSTQQSLAEKETHLTNLRAER----RKHLEEVLE-MKQEALLAAIS 868
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
E+ A+ E + +KK E V ++RE L Q++ + T+ ++L + E +
Sbjct: 869 EKDANIALLELSSSKKKTQEEVA---ALKREK--DRLVQQLKQQTQNRMKLMADNYEDDH 923
Query: 502 -KFTGSNPSLMKVPQPE 517
K + SN + K P P+
Sbjct: 924 FKSSHSNQTNHK-PSPD 939
Score = 35.9 bits (79), Expect = 1.5
Identities = 73/422 (17%), Positives = 155/422 (36%), Gaps = 28/422 (6%)
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKI-----LEQNSGA---GAKRITELK 1434
DLQ++ K++ R KDV+ K+++L++ +K L++ A +IT K
Sbjct: 153 DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYEL----LEEEHVVTKARLTVEKEQAQGELLHV 1490
++Y ++ +H +A +EL + +L ++ T E + + LH
Sbjct: 213 EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
Query: 1491 Q-----KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
+ KEL ++ ++ ++ T+ N ++ + LQ + E
Sbjct: 273 EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
Query: 1546 NARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
RL + E + + E + D + +Q
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 1606 XXXXXXXXXIEQSEKARKAEITDTKTRYE--GQMNTMRDELKSLHNQVSRFRRERDNYKQ 1663
E+ + + T+ R E QM R K + N++ + ++E
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
Query: 1664 MLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLAS 1723
L A Q + + N ++ H E + + EQ+ A L+ E+ RL
Sbjct: 453 ELLALQTKLETLTNQFSDSKQH--------IEVLKESLTAKEQRAAILQTEVDALRLRLE 504
Query: 1724 KLNTELVSEKSSAEVRLAEMQSRLNE-YEEERLLSSGRARVAGLATRMELAWHKERDEQQ 1782
+ T L + + E ++ E ++ + +L +V L ++E + RD+++
Sbjct: 505 EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEK 564
Query: 1783 RL 1784
++
Sbjct: 565 QM 566
>AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and
Golgi-localized PKN-associated protein (CG-NAP) protein.
Length = 3899
Score = 75.8 bits (178), Expect = 1e-12
Identities = 173/869 (19%), Positives = 361/869 (41%), Gaps = 85/869 (9%)
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
DEK E E +++ EQE +++ELE +++ ++++ +EL S+ K A
Sbjct: 1929 DEKTLFERQIQEKTDVIDRLEQELLCASNRLQELEAEQQQIQEE-RELLSRQKEAMKAEA 1987
Query: 758 GSNTTARRSLTTNSNKLAEERVKV---LEDEIDEVRKKLIEKERDCE-RLHAELSLAQKK 813
G + L + KL +E+++V E D+++K++ E D E ++ + L Q+K
Sbjct: 1988 GP---VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK 2044
Query: 814 PKTLIKSRSLDAS------------DQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
L+ R + + D+Q +D + + V +QE L + + +
Sbjct: 2045 NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104
Query: 862 QTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE---------MICQ 912
+ + ++++ L N ++DK +L K QL+ +++E +I++LE ++ +
Sbjct: 2105 EHQTREVEQLANHLKEKTDKCSELLLSKE-QLQRDIQERNEEIEKLEFRVRELVQALLVE 2163
Query: 913 DEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK-S 971
D K V E L++++ + L++ ++ Q+
Sbjct: 2164 DRKHFGAVEAKPELSLEVQ-LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2222
Query: 972 FKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIR 1031
+ I KK + TT+LQ +LE E M+ GL+ KE A + ++ + +
Sbjct: 2223 MQLEIQKKES--TTRLQ------ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV--LF 2272
Query: 1032 SKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLT 1091
K ++ E E ++L ++ KL+ K+ D V K + + + + + +C
Sbjct: 2273 GKFAQIIQEKEVEIDQLNEQVTKLQQ-QLKITTDNKVIEEKNELIRDLETQI--ECLMSD 2329
Query: 1092 EEM--KNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY 1149
+E +NRE +I +L+ ++ LQ +++ Q+D
Sbjct: 2330 QECVKRNREEEIEQLNEVIEK---LQQELANI---GQKTSMNAHSLSEEADSLKHQLD-- 2381
Query: 1150 TKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQL-STRKDRVTXXXXXXXXX 1208
+ +K L ++V +++ ++ ++L S +++R +
Sbjct: 2382 -VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPE 2440
Query: 1209 XXQAVVLANTHR-RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLES 1267
V + + + + +E+ +D L++ ++ ++ F + E + + E ++ LES
Sbjct: 2441 NSVNVAIDHLSKDKPELEVVLTEDALKS--LENQTYFKSFEENGKGSIINLETRLRQLES 2498
Query: 1268 TIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKI 1326
T++AKD+ + Q ++ +++ ++V ++ Q +L +
Sbjct: 2499 TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQE 2558
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQS 1386
+ + + + +L +L S E++ E+ T L
Sbjct: 2559 YAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRI--SELESQVVEMHTSLIL 2616
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
E+++++ IA +K+V K+ +L L+ L+ E+ K+ + E +T +L H
Sbjct: 2617 EKEQVE---IA-EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFH 2672
Query: 1447 SLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQA---QGELL-------HVQKELST 1496
S E + EL E L E V TKA L KE+A Q ELL +QK+LS
Sbjct: 2673 SNE-ESGFFNEL----EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKTEMQNS 1525
+ +EKL S ++TE+Q S
Sbjct: 2728 VRDHLAEAKEKL---SILEKEDETEVQES 2753
Score = 70.9 bits (166), Expect = 4e-11
Identities = 143/682 (20%), Positives = 287/682 (42%), Gaps = 70/682 (10%)
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR----ENRIKELEQEVARSTEVALRL 492
++ ++E Q E E+ E + + + G +G+Q+ E IK+ + + + T +
Sbjct: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
Query: 493 QRELAEANSKF---TGSNPSLM----KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
+RE E +F T + L ++ ET++ S S T + Q+L Q
Sbjct: 218 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH-QQQ 276
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
LE + L E + +E+ Q+ +FL +++ ++E E Q+K +
Sbjct: 277 LEEQDHLLEDYQKKKEDFT--MQI---SFLQEKI--------KVYEME------QDKKVE 317
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
++ +EK K EE + +L L++ + ++ +++
Sbjct: 318 NSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 377
Query: 666 LQLKKMATKAR-SRKLSPTPPANKLSIETANDNDEK-ETDEADPAEMKLLLELNEQEATV 723
L+L K R S + ++ N D + ETD E + +L + A +
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
+++ Q K+ L +++ +++ + G A RS + + + E+++K++
Sbjct: 438 DEMYGQQIVQMKQEL---IRQHMAQMEEIKTRHKGEMENALRSYSNIT--VNEDQIKLMN 492
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
I+E+ KL + E+L EL L ++ L R L+ DL +L
Sbjct: 493 VAINELNIKLQDTNSQKEKLKEELGLILEEKCAL--QRQLE-------DLVEELSF--SR 541
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ RA+ Q++ KL +K L +++ L+++ ++K +L++E + K
Sbjct: 542 GQIQRAR-QTIAEQESKLNEAHKSLSTVED---LKAEIVSASESRKELELKHEAEVTNYK 597
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
IK LEM+ + EK+ R E+ + E + L S Q + +++
Sbjct: 598 IK-LEML-EKEKNAVLDRMAESQEAELERL-STQLLFSHEEELSKLKEDLEIEHRISIEK 654
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED--------LECEIGEMYVVMKN-AGLSG 1014
LKD+ +K +I +++ K++ + +D L EI ++ + ++
Sbjct: 655 LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS 714
Query: 1015 KEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+EMT + +L+KEI+ +R + K E LQ + L+ + E D K+
Sbjct: 715 EEMTLQINELQKEIEILRQE-EKEKGTLEQEVQELQLKTELLEKQMKEKEND---LQEKF 770
Query: 1074 KALENENSNLSNQCKTLTEEMK 1095
LE ENS L ++ KTL + +K
Sbjct: 771 AQLEAENSILKDEKKTLEDMLK 792
Score = 62.9 bits (146), Expect = 1e-08
Identities = 133/689 (19%), Positives = 285/689 (41%), Gaps = 55/689 (7%)
Query: 267 KEYQDQIEGLKQEVDILR-KRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+++ QI L++++ + ++ ++VE + + + I+ N + L+L+ K
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 351
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
LTT ++ L + ++ + QK +EI++ +LE S + + + E+++ + E L +
Sbjct: 352 ---LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 408
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++ ++ + + R + + Y +++Q + + + KT K
Sbjct: 409 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEIKTRHK 468
Query: 445 ADQLEQEKA-------EHEKKLLEIVGGPDG--MQRENRIKE-LEQEVARSTEVALRLQR 494
+ ++ E + KL+ + +Q N KE L++E+ E LQR
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L + + + S + + Q T+ S L + DL+ + ++ R+
Sbjct: 529 QLEDLVEELSFSRGQIQRARQ--TIAEQESKLNEAHKS---LSTVEDLKAEIVSASESRK 583
Query: 555 QLR-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
+L E E N K +K + D + + E+E S Q H K
Sbjct: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA--ESQEAELERLSTQLLFSHEEELSKLK 641
Query: 614 EKSD-SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA 672
E + +SI+K + H+ + N M+ + + E+DN +
Sbjct: 642 EDLEIEHRISIEKLKDNLGIHYKQQIDGLQNEMSQ---KIETMQFEKDN---------LI 689
Query: 673 TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEATVLRRKVEEL 731
TK +++ + L N E+ T + + + ++ +L E+E L ++V+EL
Sbjct: 690 TK-QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQEL 748
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL-------AEERVKVLED 784
+ E L+KQ+KE + + N+ + T + L EER+ L+
Sbjct: 749 QLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQ---KKPKTLIKSRSLDASDQQNVDLKRQLQVIE 841
+ + + EKE + + L Q + + + K R+ + ++N ++ Q ++ E
Sbjct: 809 IKSKSKDSVWEKEIEI-LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-ELQE 866
Query: 842 QEASVLRAKTQSLEADNEKLQTENK-KLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
+ A +L+ K LE K + E K KL+ L + L + K + + +E K
Sbjct: 867 EYACLLKVK-DDLEDSKNKQELEYKSKLKALN--EELNLQRINPTTVKMKSSVFDEDKTF 923
Query: 901 LAKIKELEMICQDEKSEKKVRFTEATKKE 929
+A+ E+ + + + +E + E TK+E
Sbjct: 924 VAETLEMGEVVEKDTTE-LMENLEVTKRE 951
Score = 55.2 bits (127), Expect = 2e-06
Identities = 149/831 (17%), Positives = 342/831 (41%), Gaps = 63/831 (7%)
Query: 290 VEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIRE 349
++ E +++L + + A + SE Q + T E +R+ + +
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATES 1892
Query: 350 IESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNF 409
++ + E R ++R EQL +L AE + + DE ++++++ ++
Sbjct: 1893 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDVIDRLEQEL 1952
Query: 410 REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGM 469
++ L E +Q + +LS + + + +A +EQ+ + +KL++ + +
Sbjct: 1953 L-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK-----EKL 2006
Query: 470 QRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG 529
+ + + +++ ++ + + L+ ++ E S+F L + E + + + +
Sbjct: 2007 EVQCQAEKVRDDLQKQVKA---LEIDVEEQVSRFI----ELEQEKNTELMDLRQQNQALE 2059
Query: 530 GSQEDPAQLLRDLQDSLEREADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD 588
E + L + E E D+ +++++ E++ K V P F Q ++++
Sbjct: 2060 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ---LKVV--PRF---QPISEH----Q 2107
Query: 589 IHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN 648
E E + N ++ K + SKE+ I + EE + + + +
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQR---DIQERNEEIE-KLEFRVRELVQALLVE 2163
Query: 649 NLRKTAARVEEDNESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDEADP 707
+ RK VE E L L+++ A + A RK L + +E E +
Sbjct: 2164 D-RKHFGAVEAKPE-LSLEVQLQAERDAIDRK---EKEITNLEEQLEQFREELENKNEEV 2218
Query: 708 AEMKLLLELNEQEATVLRRKVEE----LEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
++ + LE+ ++E+T +++E+ + D E L +KE + + G
Sbjct: 2219 QQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI 2278
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCER-LHAELSLAQKKPKTLIKSRS 822
+ ++L E+ K+ + K+IE++ + R L ++ + + ++R
Sbjct: 2279 IQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR- 2337
Query: 823 LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAKSLRSDK 881
+++ L ++ ++QE + + KT S+ A + + ++ K QL + A+ L ++
Sbjct: 2338 ----EEEIEQLNEVIEKLQQELANIGQKT-SMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2392
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
++ ++ T ++N LKE K+ +L Q+ S K+ R E+ +K ++
Sbjct: 2393 QVETANEEMTFMKNVLKETNFKMNQL---TQELFSLKRER--ESVEK-IQSIPENSVNVA 2446
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTTKL-QLKKMVEDLECE 999
+ LKSL++ KSF+ +L T+L QL+ V + E
Sbjct: 2447 IDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLRQLESTVSAKDLE 2506
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT--EIAKLKD 1057
+ + Y +K+ G+ T L+K+I ++ + + + + +L+ E AK
Sbjct: 2507 LTQCYKQIKDMQEQGQFET--EMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ 2564
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
N + + + N + L + LT + E+Q+ ++ L
Sbjct: 2565 DNQTISSEPE-RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSL 2614
Score = 53.2 bits (122), Expect = 9e-06
Identities = 81/393 (20%), Positives = 158/393 (40%), Gaps = 21/393 (5%)
Query: 738 LKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKE 797
L+ V++L IS + + T + L S + +E + L+ + +E+R++L E+
Sbjct: 1850 LQAAVEKLLEAISETSSQLEHAKVT-QTELMRESFRQKQEATESLKCQ-EELRERLHEES 1907
Query: 798 RDCERLHAELSLAQKKPKTLIKSRSL-DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
R E+L ELS A+ ++L + Q+ D+ + +EQE + Q LEA
Sbjct: 1908 RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDV---IDRLEQELLCASNRLQELEA 1964
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
+ +++Q E +LL K +A + + + E +KE L + E + D +
Sbjct: 1965 EQQQIQEER---ELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK 2021
Query: 917 EKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA------QK 970
+ K + ++ + ++ +Q + K L + A +
Sbjct: 2022 QVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERD 2081
Query: 971 SFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT-AKTKLEKEIDE 1029
F+ I K L + + + E E+ ++ +K E+ +K +L+++I E
Sbjct: 2082 VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQE 2141
Query: 1030 IRSKLSKNDSEFTNEKNRLQTEIAK-LKDVNAK----LEGDKDVFANKYKALENENSNLS 1084
++ K + L E K V AK LE + E E +NL
Sbjct: 2142 RNEEIEKLEFRVRELVQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLE 2201
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
Q + EE++N+ ++ +L L+ TT
Sbjct: 2202 EQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2234
Score = 52.8 bits (121), Expect = 1e-05
Identities = 156/811 (19%), Positives = 329/811 (40%), Gaps = 80/811 (9%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT--RQIEQLRAKLLAAETL 380
+Q + TH E + E +I E+ ELE T +Q+++ A + + +
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
Query: 381 CEELMD-------ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKNCR 432
+L E ++ +E +L +Q F++ QA E +LR T +
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASE--TLRNSTHSSTAADLL 264
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ +++ ++ + +++KK + +Q + ++ E+EQ+ +V
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----KKVENSN 320
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+ E+ E + N +++ + +T+++ + LT +LL +LQ+ + ++
Sbjct: 321 KEEIQEKETIIEELNTKIIE-EEKKTLEL-KDKLTTAD------KLLGELQEQIVQK--- 369
Query: 553 REQLRNAEEETANCKQVNPPTFLD-KQVM-TDNIVTCDIHESETVTNSIQNKMIHAASTP 610
++++N + E N KQ + + KQ+M T + H+ I +M
Sbjct: 370 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ +++ + + + Q +L I HMA KT + E +N L
Sbjct: 430 LEQLRAELDEMYGQQIVQMKQ---EL----IRQHMAQMEEIKTRHKGEMENA--LRSYSN 480
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ KL N+L+I+ + N +KE + E+ L+LE L VEE
Sbjct: 481 ITVNEDQIKLMNVA-INELNIKLQDTNSQKEKLKE---ELGLILEEKCALQRQLEDLVEE 536
Query: 731 LEQDK---EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
L + + ++ + E SK++ K S + + + + S E +K E E+
Sbjct: 537 LSFSRGQIQRARQTIAEQESKLNEAHK-SLSTVEDLKAEIVSASESRKELELKH-EAEVT 594
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
+ KL E++ + ++ +Q+ + ++ L + +++ LK L+ IE S+
Sbjct: 595 NYKIKLEMLEKEKNAVLDRMAESQEAELERLSTQLLFSHEEELSKLKEDLE-IEHRISIE 653
Query: 848 RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
+ K + K Q + + ++ + ++++ +K +L TK +N+L ++K+K+L
Sbjct: 654 KLKDNL--GIHYKQQIDGLQNEMSQKIETMQFEKD-NLITK-----QNQLILEISKLKDL 705
Query: 908 EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDD 967
+ + KSE+ +KE + L+ ++ + +K ++D
Sbjct: 706 QQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEND 765
Query: 968 AQKSFKPRIPKKPTDLTTKLQLKKMVE-DLECEIGEMYVVMKNAGLSGKEMTAKTKLE-- 1024
Q+ F + K L+ M++ E + + + K+ + ++E
Sbjct: 766 LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL 825
Query: 1025 ---------------KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKD-- 1067
+EI++ R+ S + F LQ E A L V LE K+
Sbjct: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885
Query: 1068 --VFANKYKALENENSNLSNQCKTLTEEMKN 1096
+ +K KAL NE NL + T +MK+
Sbjct: 886 ELEYKSKLKAL-NEELNL-QRINPTTVKMKS 914
Score = 51.2 bits (117), Expect = 4e-05
Identities = 127/686 (18%), Positives = 284/686 (41%), Gaps = 55/686 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ ++++++++E +EV L + E +KE + RL ++ NK ++
Sbjct: 2200 LEEQLEQFREELENKNEEVQQLHMQLEIQKKEST----TRLQELEQENKLFKDDMEKLGL 2255
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
++ + ++T ++ + K Q I+E E E++ Q +++Q + K+ +
Sbjct: 2256 AIKESDAMSTQDQHVLFGK--FAQIIQEKEVEID---QLNEQVTKLQQ-QLKITTDNKVI 2309
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNC-RVLSFKLKK 440
EE + D++ ++ L ++ N RE++ ++ + + +L+Q + N + S
Sbjct: 2310 EEKNELIRDLETQIECLMSDQECVKRN-REEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2368
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAEA 499
+AD L K + + + E + ++ N + V + T + +L +EL
Sbjct: 2369 LSEEADSL---KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2425
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
+ S + +P+ +V V+ L++ E L D SLE + + N
Sbjct: 2426 KRE-RESVEKIQSIPE-NSVNVAIDHLSK-DKPELEVVLTEDALKSLENQTYFKSFEENG 2482
Query: 560 EEETAN----CKQVNPPTFLDKQVMTDNIVTC-DIHE-SETVTNSIQNKMIHAASTPSSK 613
+ N +Q+ +T D+ E + T +Q K+++ K
Sbjct: 2483 KGSIINLETRLRQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2542
Query: 614 EKSD-SPPLSIDKTTEETQFHFDLPYLSI----FNHMAANNLRKTAARVEEDNESLLLQL 668
+ + ++ E +F D +S N N LR+ + D +L L++
Sbjct: 2543 VAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED--ELGSDISALTLRI 2600
Query: 669 KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
++ ++ S K +E A N ++ E E++ LLE NE +K
Sbjct: 2601 SELESQVVEMHTSLI--LEKEQVEIAEKNVLEK--EKKLLELQKLLEGNE-------KKQ 2649
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
E E+ + +V + T+++ + S N + + K AE + +++ ++
Sbjct: 2650 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK-AE--LASYKEKAEK 2706
Query: 789 VRKKLIEKERDCERLHAELS-----LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
++++L+ KE + L +LS LA+ K K I L+ D+ V ++ + E
Sbjct: 2707 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSI----LEKEDETEVQESKKACMFEPL 2762
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
L S K+ + N+ Q+L ++ + + ++++ T++ ++ E + K
Sbjct: 2763 PIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK 2822
Query: 904 IKELEMICQDEKSEKKVRFTEATKKE 929
++EL + + + TE K+E
Sbjct: 2823 MQELHAAEILDMESRHISETETLKRE 2848
Score = 50.8 bits (116), Expect = 5e-05
Identities = 131/700 (18%), Positives = 283/700 (40%), Gaps = 54/700 (7%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
+ Q Q++ L+ +V+ R +E+EK+ L+ + ++ K+++ ++
Sbjct: 2018 DLQKQVKALEIDVEEQVSRFIELEQEKNTELM-------DLRQQNQALEKQLEKMRKFLD 2070
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELET----RPSTEAQTRQIEQLRAKLLAAETLCEE 383
E E RD Q+I+++E +L+ +P +E QTR++EQL L C E
Sbjct: 2071 EQAIDREHERDV---FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2127
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFRE-DQADEYSSLRRELEQTIKNCRVLSFKLKKTE 442
L+ E +++++++ ++ RE QA + K L +L+
Sbjct: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELVQALLVEDRKHFGAVEAKPELSLEVQLQAER 2187
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSK 502
D+ E+E E++L + + E + ++ E+ + E RLQ EL + N
Sbjct: 2188 DAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK-ESTTRLQ-ELEQENKL 2245
Query: 503 FTGSNPSL-MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
F L + + + + + + G + + ++ E+ L++QL+ +
Sbjct: 2246 FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD 2305
Query: 562 ETANCKQVNPPTFLDKQV---MTDNIVTC-----DIHESETVTNSIQNKMIH-----AAS 608
++ L+ Q+ M+D +I + V +Q ++ + + +
Sbjct: 2306 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2365
Query: 609 TPSSKEKSDSPPLSIDKT-TEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQ 667
S E++DS +D E+ + + N L++T ++ + + L
Sbjct: 2366 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQE-LFS 2424
Query: 668 LKKMATKARSRKLSPTPPANKLSIETANDNDEKE---TDEA-----DPAEMKLLLELNEQ 719
LK+ + P N + D E E T++A + K E +
Sbjct: 2425 LKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG 2484
Query: 720 EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERV 779
L ++ +LE A ++ + +I + + ++ + N K+ EE
Sbjct: 2485 SIINLETRLRQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI-VNLQKIVEE-- 2541
Query: 780 KVLEDEIDEVRKKLI-EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR-QL 837
KV + +++ + + E + C+ +++ + +T I++ + D+ D+ L
Sbjct: 2542 KVAAALVSQIQLEAVQEYAKFCQ---DNQTISSEPERTNIQNLNQLREDELGSDISALTL 2598
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENEL 897
++ E E+ V+ T SL + E+++ K + L K K L K L+ N KK Q E E
Sbjct: 2599 RISELESQVVEMHT-SLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNEKK--QREKEK 2654
Query: 898 KEALAKIKELEMICQ-DEKSEKKVRFTEATKKETDTLKSK 936
K + ++ L+ + +E+ F E +++ +K
Sbjct: 2655 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694
Score = 47.2 bits (107), Expect = 6e-04
Identities = 114/657 (17%), Positives = 264/657 (40%), Gaps = 51/657 (7%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQK- 346
ER +EK+D++ R + A+ +E ++Q++ L+ E ++ E + Q+
Sbjct: 1935 ERQIQEKTDVIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL 1994
Query: 347 IREIESELETRPSTEAQTRQI-----EQLRAKLLAAETLCEELMDENEDMKKELRDLXXX 401
++E E ++ + + Q ++ +Q++A + E ++ ++ EL DL
Sbjct: 1995 LQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQ 2054
Query: 402 XXXMQDNF-------------REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
++ RE + D + ++LEQ +K + R+ +QL
Sbjct: 2055 NQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQL 2114
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
E K E++ + +QR+ I+E +E+ + L + L + K G+
Sbjct: 2115 ANHLKEKTDKCSELLLSKEQLQRD--IQERNEEIEKLEFRVRELVQALLVEDRKHFGAVE 2172
Query: 509 SLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQ 568
+ ++ ++ R ++ R + + +L++ LE+ RE+L N EE +Q
Sbjct: 2173 AKPELSLEVQLQAERDAIDRKEKE------ITNLEEQLEQ---FREELENKNEEV---QQ 2220
Query: 569 VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL--SIDKT 626
++ + K+ T + ++ + + K+ A + D L +
Sbjct: 2221 LHMQLEIQKKESTTRLQ--ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI 2278
Query: 627 TEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPA 686
+E + D + + +EE NE L+ L+ S +
Sbjct: 2279 IQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE-LIRDLETQIECLMSDQ-ECVKRN 2336
Query: 687 NKLSIETANDNDEKETDEADPAEMKLLLELN--EQEATVLRRKVEELEQDKEALKKQV-- 742
+ IE N+ EK E K + + +EA L+ +++ + +K AL++QV
Sbjct: 2337 REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVET 2396
Query: 743 --KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK-VLEDEIDEVRKKLIEKERD 799
+E+T + + +T+ N + + + + E+++ + E+ ++ L + + +
Sbjct: 2397 ANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPE 2456
Query: 800 CERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE 859
E + E +L + +T KS + ++L+ +L+ +E S + +
Sbjct: 2457 LEVVLTEDALKSLENQTYFKSFE-ENGKGSIINLETRLRQLESTVSAKDLELTQCYKQIK 2515
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
+Q + + + K + K ++ K L ++++ L ++E CQD ++
Sbjct: 2516 DMQEQGQFETEMLQKKIVNLQKIVE--EKVAAALVSQIQ--LEAVQEYAKFCQDNQT 2568
Score = 45.6 bits (103), Expect = 0.002
Identities = 88/469 (18%), Positives = 193/469 (41%), Gaps = 35/469 (7%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA----AKD---VHIKQLE- 1280
EKDE F++ + L+ + + L+A + ++ ST A AK H +QLE
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279
Query: 1281 -DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
D L + K ++ T + ++ + + N +I+ ++T E K
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKV--ENSNKEEIQEKETIIEELNTK 337
Query: 1340 LEMAQLKS-DLA-KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-- 1395
+ + K+ +L KL + +N EL Q ER+ + ++
Sbjct: 338 IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQL 397
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI-TELKQEYEETVKKLEHSLALE 1451
+ + +KD++ T ++ +EQ + +++ EL + Y + + +++ L +
Sbjct: 398 MGTVEELQKRNHKDSQFET--DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQ 455
Query: 1452 K-AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ-KELSTALGEIKTLQEKLG 1509
A+ EE+ +++ E + + + +TV ++Q + L++V EL+ L + + +EKL
Sbjct: 456 HMAQMEEIKTRHKGEMENALRSYSNITVNEDQIK--LMNVAINELNIKLQDTNSQKEKLK 513
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHH 1569
E EK +Q + L E L +++RAR + ++E +L A+ +E
Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSRGQIQRAR--QTIAEQESKLNEAHKSLSTVEDL 571
Query: 1570 HDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDT 1629
+E +++ E E + T
Sbjct: 572 KAEIVSASESRKELELKHE--AEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLSTQL 629
Query: 1630 KTRYEGQMNTMRDELKSLHNQVSRFRRERDN----YKQMLEAAQKSMAE 1674
+E +++ ++++L+ + +++S + +DN YKQ ++ Q M++
Sbjct: 630 LFSHEEELSKLKEDLE-IEHRIS-IEKLKDNLGIHYKQQIDGLQNEMSQ 676
Score = 44.8 bits (101), Expect = 0.003
Identities = 124/666 (18%), Positives = 261/666 (39%), Gaps = 57/666 (8%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
E LQ+++ +L R + + Q I E ES+L +E L+A++++A
Sbjct: 522 EKCALQRQLEDLVEELSFSRGQIQRARQTIAEQESKLN---EAHKSLSTVEDLKAEIVSA 578
Query: 378 ETLCEELMDENE----DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN-CR 432
+EL ++E + K +L L + D E Q E L +L + +
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLSTQLLFSHEEELS 638
Query: 433 VLSFKLKKTER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
L L+ R ++L+ H K+ ++ + + E E + + + ++ L
Sbjct: 639 KLKEDLEIEHRISIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 698
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPET---VKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
+ + L + S M + E +++ R G+ E Q L+ + LE+
Sbjct: 699 ISK-LKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757
Query: 549 -----EADLREQLRNAEEETANCKQVNPPTFLDKQVMT-----DNIVTCDIHESETVTNS 598
E DL+E+ E E + K ++ T + ++ D +S++ +S
Sbjct: 758 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKS-KDS 816
Query: 599 IQNKMIHAASTPSSKEKSDSPPLS--IDKTTEETQF---HFDLPYLSIFNHMAANNLRKT 653
+ K I + K L+ I+K F +F++ Y + A L K
Sbjct: 817 VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC--LLKV 874
Query: 654 AARVEEDNESLLLQ----LKKMATKARSRKLSPTPPANKLSIE------TANDNDEKETD 703
+E+ L+ LK + + ++++PT K S+ A + E
Sbjct: 875 KDDLEDSKNKQELEYKSKLKALNEELNLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVV 934
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
E D E+ LE+ ++E L +++ +L + + ++ L ++ S+ + +
Sbjct: 935 EKDTTELMENLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRC 994
Query: 764 RR-SLTTNSNKLAE------ERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKT 816
R + N N+ + + +L+ + + + E S + K
Sbjct: 995 RELEIIINHNRAEDVQSCDTQESSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV 1054
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLK 872
++ ++ +Q + L + +E+S LRA S L+ + L++E L+L
Sbjct: 1055 SFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPSENDKLQKELNVLKSEQNDLRLQM 1113
Query: 873 NAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
A+ + + + + +ENE +AL +KE + Q+EK ++ + + E
Sbjct: 1114 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL---ELQ 1170
Query: 932 TLKSKQ 937
T+K+++
Sbjct: 1171 TMKTQE 1176
Score = 42.7 bits (96), Expect = 0.013
Identities = 81/447 (18%), Positives = 183/447 (40%), Gaps = 25/447 (5%)
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK- 1434
+AK+ Q + ++ D + + K ++ +++ L+ K+K+ E + + +
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
QE E +++L + E+ + EL K ++ + ++ + ++ + L +
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSK 384
Query: 1495 STALGEIKTLQEKLGT--ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+ +++ +GT E N + ++ + I E+ E RA L+ Q+
Sbjct: 385 QKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 444
Query: 1553 ERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+++ R+ + + + Y ++ +
Sbjct: 445 IVQMKQELIRQHMAQME-EIKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ 503
Query: 1613 XXIEQSEKARK--AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
Q EK ++ I + K + Q+ + +EL Q+ R R+ + L A K
Sbjct: 504 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRGQIQRARQTIAEQESKLNEAHK 563
Query: 1671 SMA---EIKNGDKSARIHRNSISSTDEEE---YRNKVALLEQQVACLEDELCESR-LLAS 1723
S++ ++K SA R + E E Y+ K+ +LE++ + D + ES+
Sbjct: 564 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 1724 KLNTELV---SEKSSAEVRLAEMQSRLN-EYEEERLLSSGRARVAGLATRME-----LAW 1774
+L+T+L+ E+ S E++ R++ E ++ L + ++ GL M + +
Sbjct: 624 RLSTQLLFSHEEELSKLKEDLEIEHRISIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
Query: 1775 HKER--DEQQRLLQETSTLARDLRQTL 1799
K+ +Q +L+ E S L +DL+Q+L
Sbjct: 684 EKDNLITKQNQLILEISKL-KDLQQSL 709
Score = 41.1 bits (92), Expect = 0.039
Identities = 73/339 (21%), Positives = 145/339 (42%), Gaps = 26/339 (7%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
+ +EL+S KD R + + + + + + +LK++ LE+T+ A+ H+K+LE
Sbjct: 3128 MQVELSSMKD----RATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE- 3182
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
A R DK DE V + + Q L K KL ++E E +LE
Sbjct: 3183 AFRLEVKDKTDE----VHL--LNDTLASEHKKSRELQWALEKEKAKLGRSE-ERDKEELE 3235
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKEL--DTDLQSER-KKLDRMRIAH 1398
+ + K N S + +++ + D L E+ + L+ +
Sbjct: 3236 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLQ 3295
Query: 1399 DKDVKNKDAELATLKGKLKI---LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEY 1455
+ V+ ++ +TL + ++ L+ + G G R L E+ +K+L+ L + +
Sbjct: 3296 SQKVRIREMS-STLDRERELHAQLQSSDGTGQSR-PPLPS--EDLLKELQKQLEEKHSRI 3351
Query: 1456 EELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
EL + E + + + T+ ++ ++ Q + L ++E +T G+ K + + E
Sbjct: 3352 VELLNETEKYKLDSLQTRQQMEKDR-QVHRKTLQTEQEANTE-GQKKMHELQSKVEDLQR 3409
Query: 1516 NTEKTEMQNSIASLQ-ERLCGGGWEVERARLNARLDQRE 1553
E+ Q L+ +RL G E ++ L R ++RE
Sbjct: 3410 QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELE-REEKRE 3447
Score = 39.9 bits (89), Expect = 0.091
Identities = 70/313 (22%), Positives = 140/313 (44%), Gaps = 25/313 (7%)
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD 703
H N + T R +E + L+ + +S+ L + + ++ ++
Sbjct: 3090 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3149
Query: 704 EADPAEMKLLLELNEQEA-TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ AE+K L + E T L+ + + L++ EA + +VK+ T ++ + T A +
Sbjct: 3150 KMVVAELKSELAQTKLELETTLKAQHKHLKE-LEAFRLEVKDKTDEVHLLNDTLASEHKK 3208
Query: 763 ARR---SLTTNSNKL--AEERVKVLEDEIDEVRKKL-IEKERDCE---RLHAELSLAQKK 813
+R +L KL +EER K +E+++++ L +K+R+ + L + L +
Sbjct: 3209 SRELQWALEKEKAKLGRSEERDK---EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3265
Query: 814 PKTLIKSRSL-DASDQQNVDLKRQLQVIEQEASV-LRAKTQSLEADNE---KLQTENKKL 868
+ + R L DA + +LQV+ Q V +R + +L+ + E +LQ+ +
Sbjct: 3266 QQKIESQRMLYDAQLSEEQGRNLELQVLLQSQKVRIREMSSTLDRERELHAQLQSSDGTG 3325
Query: 869 QL---LKNAKSLRS-DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTE 924
Q L + L+ K L+ + +L NE ++ K+ L+ Q EK + R T
Sbjct: 3326 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKTL 3383
Query: 925 ATKKETDTLKSKQ 937
T++E +T K+
Sbjct: 3384 QTEQEANTEGQKK 3396
Score = 36.3 bits (80), Expect = 1.1
Identities = 54/254 (21%), Positives = 113/254 (44%), Gaps = 24/254 (9%)
Query: 1260 NKITSLESTIAAKDVHIKQLEDALRQTTND-KYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
++I +L + + + + +K+ +++ + + +Y+ +M+EM+ Q
Sbjct: 3084 SEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3143
Query: 1319 DELNNAKIKLEKTEAESSAAKLEM-AQLKSD---LAKLENXXXXXXXXXXXXXXXS---S 1371
++L++ K+ + + ++E + KLE+ LK+ L +LE + +
Sbjct: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203
Query: 1372 YWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRIT 1431
K++EL L+ E+ KL R DK+ EL LK L+ +Q + +
Sbjct: 3204 SEHKKSRELQWALEKEKAKLGRSE-ERDKE------ELEDLKFSLESQKQRNLQLNLLLE 3256
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGK----YELLEEEHV-VTKARLTVEKEQAQGE 1486
+ KQ E+ +K+E L A+ E G+ LL+ + V + + T+++E+
Sbjct: 3257 QQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLQSQKVRIREMSSTLDRERE--- 3313
Query: 1487 LLHVQKELSTALGE 1500
LH Q + S G+
Sbjct: 3314 -LHAQLQSSDGTGQ 3326
Score = 35.9 bits (79), Expect = 1.5
Identities = 69/405 (17%), Positives = 166/405 (40%), Gaps = 23/405 (5%)
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSA---GSNTTARRSLTTNSNKLAEERVKVLEDEI 786
EL+ ++ K +++E++S + + A S+ T + S L +E K LE++
Sbjct: 3289 ELQVLLQSQKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKH 3348
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+ + L E E+ +L + + Q + + ++L + N + ++++ ++ +
Sbjct: 3349 SRIVELLNETEK--YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3406
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L+ + + KL E ++LQ + ++ + +L ++ + L + L +
Sbjct: 3407 LQRQLEEKRQQVYKLDLEGQRLQGI-----MQEFQKQELEREEKRESRRILYQNLNEPTT 3461
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
+ ++ + E KE++ K + Q L+
Sbjct: 3462 WSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKL-QCVASKLQV 3520
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
QK+ + R+ + D + +++ ++++ ++ ++ T+ L +
Sbjct: 3521 LPQKASE-RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTER 3579
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-------VNAKLEGDKDVFANKYKALE-- 1077
+ ++L+ + S+ T EKN L+ + KL++ A + N +E
Sbjct: 3580 LLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAI 3639
Query: 1078 --NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+E + + TL + +K EA++ KL A+L+N + LQT D
Sbjct: 3640 IASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 3684
>BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 75.4 bits (177), Expect = 2e-12
Identities = 122/626 (19%), Positives = 266/626 (42%), Gaps = 36/626 (5%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLA 376
EV +LQ+++ + +++++E++ + + E+ S+ + + +Q +E+ +L
Sbjct: 622 EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 681
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
++ E E + E+RDL M D + E +E+ ++ + L
Sbjct: 682 NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQD 741
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
L E + D L K E E L+ + + + +L+++ + ALR E
Sbjct: 742 LLIAKEEQEDLL--RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ-ALRESVEE 798
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
A N + S + + Q T R L QE+ +L ++ R A L+ Q+
Sbjct: 799 ATKNVEVLASRSNTSEQDQAGT--EMRVKLL----QEENEKLQGRSEELERRVAQLQRQI 852
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT--NSIQNKMIHAASTPSSKE 614
+ + + A K+ + + + + +V E E V+ +++N+ + AA S+
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE-LEAAQGNLSQT 911
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
+ LS +K EE++ L L +L KT +++++ +++ + +T
Sbjct: 912 TQEQKQLS-EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD-IVEASRTSTL 969
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-----LELNEQEATVLRRKVE 729
+L N+ + +++T EA+ + + + + L E+E +R +
Sbjct: 970 ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 730 ELEQDKEALKKQVKELTSKI----------SSVTKTSAGSNTTARRSL--TTNSNKLAEE 777
E ++ L++ +K+L ++ S + K + L N++ L E
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R+ ++++++R +L+++ + L + +++ K L KSR + + +
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDL-KSRIIHLEGSYRSSKEGLV 1148
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAKSLRSDKALDLNTKKTTQLENE 896
+E + L + +S E D LQ N++L+ +K D+ L L +K QL
Sbjct: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQK-DQLSLR 1207
Query: 897 LKEALAKIKEL-EMICQDEKSEKKVR 921
LK +++E E I + E S+KK++
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQ 1233
Score = 59.3 bits (137), Expect = 1e-07
Identities = 121/634 (19%), Positives = 261/634 (41%), Gaps = 45/634 (7%)
Query: 676 RSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLLLELNEQEAT-VLRRKVEELEQ 733
R+ SP A K+S++T + ++ + T + + +L + NE+ A +L ++E
Sbjct: 509 RAAATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGST 568
Query: 734 DKE-ALKKQVKELTSKISSVTKTSAGS---NTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
D + A K++V + KI ++ +AGS N A S T+ L E++ K L E+ E+
Sbjct: 569 DNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS-TSEVKDLLEQKSK-LTIEVAEL 626
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
+++L + ++ + + E + + L + ++N L+++L+ E E
Sbjct: 627 QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKV--EENSTLQQRLEESEGELRKNLE 684
Query: 850 KTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEM 909
+ ++ + E+ QTE + LQ + D A ++ L EL +A +++L +
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL-L 743
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
I ++E+ E +R K+E + K A L++L++ +
Sbjct: 744 IAKEEQ-EDLLR-----KRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE 797
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
++ K + + T Q + E+ + +N L G+ +LE+ + +
Sbjct: 798 EATK-NVEVLASRSNTSEQ-----DQAGTEMRVKLLQEENEKLQGRS----EELERRVAQ 847
Query: 1030 IRSKLS--KNDSEFTNEK-NRLQTEIAKLKD--VNAKLEGDKDVFANKYKALENENSNLS 1084
++ ++ K D E + + EI +L++ V+A+ E + V A + ALENE
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR--ALENELEAAQ 905
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD--CMXXXXXXXXXXXXXXXXXXXX 1142
T+E K ++ + S + L+ M +
Sbjct: 906 GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965
Query: 1143 XXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXX 1202
++ ++D+ K K +E+ + +++ + +++ ++ ++ +
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 1203 XXXXXXXXQAVVLANTHRRLSIELTSE---KDELQARFIK-TESKFITLEAEMRDLKADY 1258
+ +L T + L EL ++ KD+ ++R +K E K LE E+ + +
Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD-RSRLVKQMEDKVSQLEMELEEER--- 1081
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
N L I+ ++QL + L Q + D
Sbjct: 1082 -NNSDLLSERISRSREQMEQLRNELLQERAARQD 1114
Score = 58.0 bits (134), Expect = 3e-07
Identities = 140/716 (19%), Positives = 292/716 (40%), Gaps = 74/716 (10%)
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
E + L+R+L+ +KN + + ++ ER LE+ +++H +K+ E + R+
Sbjct: 622 EVAELQRQLQLEVKNQQNIK---EERERMRANLEELRSQHNEKVEE------NSTLQQRL 672
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSS-LTRGGSQED 534
+E E E+ ++ E +++ E + ++ L ++ E RS +G E+
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM-HDELDSAKRSEDREKGALIEE 731
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI---VTCDIHE 591
Q +DLQD L + + + LR E E K D + ++
Sbjct: 732 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 592 -SETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF----HFDLPYLSIFNHMA 646
E+V + +N + A+ + +S++ + + EE + +L
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 647 ANNLRKTAARVEED---NESLLLQLKKMATKARSRKLSPTPPANKLS--IETANDNDEKE 701
+L+ A+ +E E + QL++ AR + L +E A N +
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 911
Query: 702 TDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
T E KL E ++E LRR E+E ++ L K +++L +++ + +
Sbjct: 912 TQEQKQLSEKLKEESEQKEQ--LRRLKNEMENERWHLGKTIEKLQKEMADIVEA------ 963
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
+R S N+L E + K E+ E++++L EK + E+ + L+ + + + +
Sbjct: 964 -SRTSTLELQNQLDEYKEKNRR-ELAEMQRQLKEKTLEAEK--SRLTAMKMQDEMRLMEE 1019
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
L R Q + EA K Q LE + L+ E + LK+ +S R K
Sbjct: 1020 EL-----------RDYQRAQDEALT---KRQLLEQTLKDLEYELEAKSHLKDDRS-RLVK 1064
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
++ K +QLE EL+E E D SE+ R ++++ + L+++
Sbjct: 1065 QME---DKVSQLEMELEE--------ERNNSDLLSERISR----SREQMEQLRNELLQER 1109
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
LKS + S+ R K+ + + ++ ++ + LE E
Sbjct: 1110 AARQDLECDKISLERQNKDLKSRIIHLEGSY--RSSKEGLVVQMEARIAELEDRLESEER 1167
Query: 1002 EMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
+ N LS + + K K L ++D+ L+ + + ++ ++ + ++
Sbjct: 1168 DR----ANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEID 1223
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE K + + + N +L Q ++ ++++ ++ +K+ D+ + L T
Sbjct: 1224 RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLP-SKVLDDMDDDDDLST 1278
Score = 55.6 bits (128), Expect = 2e-06
Identities = 108/525 (20%), Positives = 206/525 (39%), Gaps = 36/525 (6%)
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
+QL+ ++ N K + + E+R Q L ++ +L K E
Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 687
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
K+E Q ++++ L++ K ++ LQ+++ D +
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED--REKGALIEELLQAKQDLQDLLIA 745
Query: 1397 AHDKD--VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+++ ++ ++ EL LKG LK + + + + +LK++Y+ ++ L S+
Sbjct: 746 KEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQALRESVEEATKN 802
Query: 1455 YEELTGKYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
E L + E++ T+ R L E E+ QG +++ ++ +I+ L+ G E
Sbjct: 803 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK---GDE 859
Query: 1512 SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHD 1571
+ A T K + + I L+E L E E+ ++AR E EL AA
Sbjct: 860 AKAKETLK-KYEGEIRQLEEALVHARKE-EKEAVSAR-RALENELEAAQGNLSQTTQEQK 916
Query: 1572 XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
R+ I ++ + E+ +
Sbjct: 917 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISS 1691
Y+ + N R EL + Q+ E + K L A K E++ ++ R ++ +
Sbjct: 977 EYK-EKN--RRELAEMQRQLKEKTLEAE--KSRL-TAMKMQDEMRLMEEELRDYQRA--- 1027
Query: 1692 TDEEEYRNKVALLEQQVACLEDEL-CESRLL--ASKLNTELVSEKSSAEVRLAEMQSRLN 1748
++E K LLEQ + LE EL +S L S+L ++ + S E+ L E ++ +
Sbjct: 1028 --QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSD 1085
Query: 1749 EYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
E +S R ++ L R EL +ER +Q L + +L R
Sbjct: 1086 LLSER--ISRSREQMEQL--RNELL--QERAARQDLECDKISLER 1124
Score = 55.2 bits (127), Expect = 2e-06
Identities = 98/533 (18%), Positives = 214/533 (40%), Gaps = 41/533 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
++++ QE+D L+++ + + + + N++ + + + +V L
Sbjct: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 330 TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENE 389
NE L+ + L +++ +++ ++E EA+ + E L+ L E L+ +
Sbjct: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK--ETLKKYEGEIRQLEEALVHARK 885
Query: 390 DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLE 449
+ K+ + + R +E + + L QT + + LS KLK+ + +QL
Sbjct: 886 EEKEAV------------SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLR 933
Query: 450 QEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPS 509
+ K E E + + G E KE+ V S L LQ +L E K
Sbjct: 934 RLKNEMENERWHL-----GKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE 988
Query: 510 LMKVPQPETVKVSRSSLTRGGSQEDPAQL---LRDLQ----DSLEREADLREQLRNAEEE 562
+ + + +T++ +S LT Q++ + LRD Q ++L + L + L++ E E
Sbjct: 989 MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
Query: 563 -TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + L KQ M D + ++ E NS ++ + S ++
Sbjct: 1049 LEAKSHLKDDRSRLVKQ-MEDKVSQLEMELEEERNNS---DLLSERISRSREQMEQLRNE 1104
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+ + D L N + + E L++Q++ + R S
Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLES 1164
Query: 682 PTPPANKLSIETANDNDEKETDE----ADPAEMKLLLELNEQEATV--LRRKVEELEQDK 735
++ +++ +N E++ E D + L + ++ + ++R+VEE E++
Sbjct: 1165 --EERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEI 1222
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
+ L+ K+L ++ + + + + +L + KVL+D D+
Sbjct: 1223 DRLESSKKKLQRELEE--QMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDD 1273
Score = 50.0 bits (114), Expect = 8e-05
Identities = 85/441 (19%), Positives = 179/441 (40%), Gaps = 39/441 (8%)
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIA---HDKDVKNKDAELATLKGKL----KILEQN 1422
+S + + +E + +L+ ++L ++++ H ++++ +L+ + +L + ++
Sbjct: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 724
Query: 1423 SGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQ 1482
GA + + + KQ+ ++ + E L + ELT L+EE + KEQ
Sbjct: 725 KGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 784
Query: 1483 AQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER 1542
EL +++ + A ++ L + T + TEM+ + LQE E
Sbjct: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQ--DQAGTEMR--VKLLQE---------EN 831
Query: 1543 ARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXX 1602
+L R ++ ER R A +R + + D YE +
Sbjct: 832 EKLQGRSEELER--RVAQLQRQIEDLKGD-----EAKAKETLKKYEGEIRQLEEALVHAR 884
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
+E +A + ++ T T+ + Q++ E Q+ R + E +N +
Sbjct: 885 KEEKEAVSARRALENELEAAQGNLSQT-TQEQKQLSEKLKEESEQKEQLRRLKNEMENER 943
Query: 1663 ----QMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES 1718
+ +E QK MA+I +++ + + +E+ R ++A +++Q+ E +S
Sbjct: 944 WHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 1003
Query: 1719 RLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKER 1778
RL A K+ E+ E L + Q +E +R L + L +E H +
Sbjct: 1004 RLTAMKMQDEM----RLMEEELRDYQRAQDEALTKRQLL--EQTLKDLEYELEAKSHL-K 1056
Query: 1779 DEQQRLLQETSTLARDLRQTL 1799
D++ RL+++ L L
Sbjct: 1057 DDRSRLVKQMEDKVSQLEMEL 1077
>BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 75.4 bits (177), Expect = 2e-12
Identities = 122/626 (19%), Positives = 266/626 (42%), Gaps = 36/626 (5%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLA 376
EV +LQ+++ + +++++E++ + + E+ S+ + + +Q +E+ +L
Sbjct: 622 EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 681
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
++ E E + E+RDL M D + E +E+ ++ + L
Sbjct: 682 NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQD 741
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
L E + D L K E E L+ + + + +L+++ + ALR E
Sbjct: 742 LLIAKEEQEDLL--RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ-ALRESVEE 798
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
A N + S + + Q T R L QE+ +L ++ R A L+ Q+
Sbjct: 799 ATKNVEVLASRSNTSEQDQAGT--EMRVKLL----QEENEKLQGRSEELERRVAQLQRQI 852
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT--NSIQNKMIHAASTPSSKE 614
+ + + A K+ + + + + +V E E V+ +++N+ + AA S+
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE-LEAAQGNLSQT 911
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
+ LS +K EE++ L L +L KT +++++ +++ + +T
Sbjct: 912 TQEQKQLS-EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD-IVEASRTSTL 969
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-----LELNEQEATVLRRKVE 729
+L N+ + +++T EA+ + + + + L E+E +R +
Sbjct: 970 ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 730 ELEQDKEALKKQVKELTSKI----------SSVTKTSAGSNTTARRSL--TTNSNKLAEE 777
E ++ L++ +K+L ++ S + K + L N++ L E
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R+ ++++++R +L+++ + L + +++ K L KSR + + +
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDL-KSRIIHLEGSYRSSKEGLV 1148
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAKSLRSDKALDLNTKKTTQLENE 896
+E + L + +S E D LQ N++L+ +K D+ L L +K QL
Sbjct: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQK-DQLSLR 1207
Query: 897 LKEALAKIKEL-EMICQDEKSEKKVR 921
LK +++E E I + E S+KK++
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQ 1233
Score = 59.3 bits (137), Expect = 1e-07
Identities = 121/634 (19%), Positives = 261/634 (41%), Gaps = 45/634 (7%)
Query: 676 RSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLLLELNEQEAT-VLRRKVEELEQ 733
R+ SP A K+S++T + ++ + T + + +L + NE+ A +L ++E
Sbjct: 509 RAAATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGST 568
Query: 734 DKE-ALKKQVKELTSKISSVTKTSAGS---NTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
D + A K++V + KI ++ +AGS N A S T+ L E++ K L E+ E+
Sbjct: 569 DNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS-TSEVKDLLEQKSK-LTIEVAEL 626
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
+++L + ++ + + E + + L + ++N L+++L+ E E
Sbjct: 627 QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKV--EENSTLQQRLEESEGELRKNLE 684
Query: 850 KTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEM 909
+ ++ + E+ QTE + LQ + D A ++ L EL +A +++L +
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL-L 743
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
I ++E+ E +R K+E + K A L++L++ +
Sbjct: 744 IAKEEQ-EDLLR-----KRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE 797
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
++ K + + T Q + E+ + +N L G+ +LE+ + +
Sbjct: 798 EATK-NVEVLASRSNTSEQ-----DQAGTEMRVKLLQEENEKLQGRS----EELERRVAQ 847
Query: 1030 IRSKLS--KNDSEFTNEK-NRLQTEIAKLKD--VNAKLEGDKDVFANKYKALENENSNLS 1084
++ ++ K D E + + EI +L++ V+A+ E + V A + ALENE
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR--ALENELEAAQ 905
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD--CMXXXXXXXXXXXXXXXXXXXX 1142
T+E K ++ + S + L+ M +
Sbjct: 906 GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965
Query: 1143 XXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXX 1202
++ ++D+ K K +E+ + +++ + +++ ++ ++ +
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 1203 XXXXXXXXQAVVLANTHRRLSIELTSE---KDELQARFIK-TESKFITLEAEMRDLKADY 1258
+ +L T + L EL ++ KD+ ++R +K E K LE E+ + +
Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD-RSRLVKQMEDKVSQLEMELEEER--- 1081
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
N L I+ ++QL + L Q + D
Sbjct: 1082 -NNSDLLSERISRSREQMEQLRNELLQERAARQD 1114
Score = 58.0 bits (134), Expect = 3e-07
Identities = 140/716 (19%), Positives = 292/716 (40%), Gaps = 74/716 (10%)
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
E + L+R+L+ +KN + + ++ ER LE+ +++H +K+ E + R+
Sbjct: 622 EVAELQRQLQLEVKNQQNIK---EERERMRANLEELRSQHNEKVEE------NSTLQQRL 672
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSS-LTRGGSQED 534
+E E E+ ++ E +++ E + ++ L ++ E RS +G E+
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM-HDELDSAKRSEDREKGALIEE 731
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI---VTCDIHE 591
Q +DLQD L + + + LR E E K D + ++
Sbjct: 732 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 592 -SETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF----HFDLPYLSIFNHMA 646
E+V + +N + A+ + +S++ + + EE + +L
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 647 ANNLRKTAARVEED---NESLLLQLKKMATKARSRKLSPTPPANKLS--IETANDNDEKE 701
+L+ A+ +E E + QL++ AR + L +E A N +
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 911
Query: 702 TDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
T E KL E ++E LRR E+E ++ L K +++L +++ + +
Sbjct: 912 TQEQKQLSEKLKEESEQKEQ--LRRLKNEMENERWHLGKTIEKLQKEMADIVEA------ 963
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
+R S N+L E + K E+ E++++L EK + E+ + L+ + + + +
Sbjct: 964 -SRTSTLELQNQLDEYKEKNRR-ELAEMQRQLKEKTLEAEK--SRLTAMKMQDEMRLMEE 1019
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
L R Q + EA K Q LE + L+ E + LK+ +S R K
Sbjct: 1020 EL-----------RDYQRAQDEALT---KRQLLEQTLKDLEYELEAKSHLKDDRS-RLVK 1064
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
++ K +QLE EL+E E D SE+ R ++++ + L+++
Sbjct: 1065 QME---DKVSQLEMELEE--------ERNNSDLLSERISR----SREQMEQLRNELLQER 1109
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
LKS + S+ R K+ + + ++ ++ + LE E
Sbjct: 1110 AARQDLECDKISLERQNKDLKSRIIHLEGSY--RSSKEGLVVQMEARIAELEDRLESEER 1167
Query: 1002 EMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
+ N LS + + K K L ++D+ L+ + + ++ ++ + ++
Sbjct: 1168 DR----ANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEID 1223
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE K + + + N +L Q ++ ++++ ++ +K+ D+ + L T
Sbjct: 1224 RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLP-SKVLDDMDDDDDLST 1278
Score = 55.6 bits (128), Expect = 2e-06
Identities = 108/525 (20%), Positives = 206/525 (39%), Gaps = 36/525 (6%)
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
+QL+ ++ N K + + E+R Q L ++ +L K E
Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 687
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
K+E Q ++++ L++ K ++ LQ+++ D +
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED--REKGALIEELLQAKQDLQDLLIA 745
Query: 1397 AHDKD--VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+++ ++ ++ EL LKG LK + + + + +LK++Y+ ++ L S+
Sbjct: 746 KEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQALRESVEEATKN 802
Query: 1455 YEELTGKYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
E L + E++ T+ R L E E+ QG +++ ++ +I+ L+ G E
Sbjct: 803 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK---GDE 859
Query: 1512 SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHD 1571
+ A T K + + I L+E L E E+ ++AR E EL AA
Sbjct: 860 AKAKETLK-KYEGEIRQLEEALVHARKE-EKEAVSAR-RALENELEAAQGNLSQTTQEQK 916
Query: 1572 XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
R+ I ++ + E+ +
Sbjct: 917 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISS 1691
Y+ + N R EL + Q+ E + K L A K E++ ++ R ++ +
Sbjct: 977 EYK-EKN--RRELAEMQRQLKEKTLEAE--KSRL-TAMKMQDEMRLMEEELRDYQRA--- 1027
Query: 1692 TDEEEYRNKVALLEQQVACLEDEL-CESRLL--ASKLNTELVSEKSSAEVRLAEMQSRLN 1748
++E K LLEQ + LE EL +S L S+L ++ + S E+ L E ++ +
Sbjct: 1028 --QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSD 1085
Query: 1749 EYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
E +S R ++ L R EL +ER +Q L + +L R
Sbjct: 1086 LLSER--ISRSREQMEQL--RNELL--QERAARQDLECDKISLER 1124
Score = 55.2 bits (127), Expect = 2e-06
Identities = 98/533 (18%), Positives = 214/533 (40%), Gaps = 41/533 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
++++ QE+D L+++ + + + + N++ + + + +V L
Sbjct: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 330 TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENE 389
NE L+ + L +++ +++ ++E EA+ + E L+ L E L+ +
Sbjct: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK--ETLKKYEGEIRQLEEALVHARK 885
Query: 390 DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLE 449
+ K+ + + R +E + + L QT + + LS KLK+ + +QL
Sbjct: 886 EEKEAV------------SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLR 933
Query: 450 QEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPS 509
+ K E E + + G E KE+ V S L LQ +L E K
Sbjct: 934 RLKNEMENERWHL-----GKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE 988
Query: 510 LMKVPQPETVKVSRSSLTRGGSQEDPAQL---LRDLQ----DSLEREADLREQLRNAEEE 562
+ + + +T++ +S LT Q++ + LRD Q ++L + L + L++ E E
Sbjct: 989 MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
Query: 563 -TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + L KQ M D + ++ E NS ++ + S ++
Sbjct: 1049 LEAKSHLKDDRSRLVKQ-MEDKVSQLEMELEEERNNS---DLLSERISRSREQMEQLRNE 1104
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+ + D L N + + E L++Q++ + R S
Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLES 1164
Query: 682 PTPPANKLSIETANDNDEKETDE----ADPAEMKLLLELNEQEATV--LRRKVEELEQDK 735
++ +++ +N E++ E D + L + ++ + ++R+VEE E++
Sbjct: 1165 --EERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEI 1222
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
+ L+ K+L ++ + + + + +L + KVL+D D+
Sbjct: 1223 DRLESSKKKLQRELEE--QMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDD 1273
Score = 50.0 bits (114), Expect = 8e-05
Identities = 85/441 (19%), Positives = 179/441 (40%), Gaps = 39/441 (8%)
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIA---HDKDVKNKDAELATLKGKL----KILEQN 1422
+S + + +E + +L+ ++L ++++ H ++++ +L+ + +L + ++
Sbjct: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 724
Query: 1423 SGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQ 1482
GA + + + KQ+ ++ + E L + ELT L+EE + KEQ
Sbjct: 725 KGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 784
Query: 1483 AQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER 1542
EL +++ + A ++ L + T + TEM+ + LQE E
Sbjct: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQ--DQAGTEMR--VKLLQE---------EN 831
Query: 1543 ARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXX 1602
+L R ++ ER R A +R + + D YE +
Sbjct: 832 EKLQGRSEELER--RVAQLQRQIEDLKGD-----EAKAKETLKKYEGEIRQLEEALVHAR 884
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
+E +A + ++ T T+ + Q++ E Q+ R + E +N +
Sbjct: 885 KEEKEAVSARRALENELEAAQGNLSQT-TQEQKQLSEKLKEESEQKEQLRRLKNEMENER 943
Query: 1663 ----QMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES 1718
+ +E QK MA+I +++ + + +E+ R ++A +++Q+ E +S
Sbjct: 944 WHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 1003
Query: 1719 RLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKER 1778
RL A K+ E+ E L + Q +E +R L + L +E H +
Sbjct: 1004 RLTAMKMQDEM----RLMEEELRDYQRAQDEALTKRQLL--EQTLKDLEYELEAKSHL-K 1056
Query: 1779 DEQQRLLQETSTLARDLRQTL 1799
D++ RL+++ L L
Sbjct: 1057 DDRSRLVKQMEDKVSQLEMEL 1077
>BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 75.4 bits (177), Expect = 2e-12
Identities = 122/626 (19%), Positives = 266/626 (42%), Gaps = 36/626 (5%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLA 376
EV +LQ+++ + +++++E++ + + E+ S+ + + +Q +E+ +L
Sbjct: 622 EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 681
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
++ E E + E+RDL M D + E +E+ ++ + L
Sbjct: 682 NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQD 741
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
L E + D L K E E L+ + + + +L+++ + ALR E
Sbjct: 742 LLIAKEEQEDLL--RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ-ALRESVEE 798
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
A N + S + + Q T R L QE+ +L ++ R A L+ Q+
Sbjct: 799 ATKNVEVLASRSNTSEQDQAGT--EMRVKLL----QEENEKLQGRSEELERRVAQLQRQI 852
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT--NSIQNKMIHAASTPSSKE 614
+ + + A K+ + + + + +V E E V+ +++N+ + AA S+
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE-LEAAQGNLSQT 911
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
+ LS +K EE++ L L +L KT +++++ +++ + +T
Sbjct: 912 TQEQKQLS-EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD-IVEASRTSTL 969
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-----LELNEQEATVLRRKVE 729
+L N+ + +++T EA+ + + + + L E+E +R +
Sbjct: 970 ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 730 ELEQDKEALKKQVKELTSKI----------SSVTKTSAGSNTTARRSL--TTNSNKLAEE 777
E ++ L++ +K+L ++ S + K + L N++ L E
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R+ ++++++R +L+++ + L + +++ K L KSR + + +
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDL-KSRIIHLEGSYRSSKEGLV 1148
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAKSLRSDKALDLNTKKTTQLENE 896
+E + L + +S E D LQ N++L+ +K D+ L L +K QL
Sbjct: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQK-DQLSLR 1207
Query: 897 LKEALAKIKEL-EMICQDEKSEKKVR 921
LK +++E E I + E S+KK++
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQ 1233
Score = 59.3 bits (137), Expect = 1e-07
Identities = 121/634 (19%), Positives = 261/634 (41%), Gaps = 45/634 (7%)
Query: 676 RSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLLLELNEQEAT-VLRRKVEELEQ 733
R+ SP A K+S++T + ++ + T + + +L + NE+ A +L ++E
Sbjct: 509 RAAATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGST 568
Query: 734 DKE-ALKKQVKELTSKISSVTKTSAGS---NTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
D + A K++V + KI ++ +AGS N A S T+ L E++ K L E+ E+
Sbjct: 569 DNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS-TSEVKDLLEQKSK-LTIEVAEL 626
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
+++L + ++ + + E + + L + ++N L+++L+ E E
Sbjct: 627 QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKV--EENSTLQQRLEESEGELRKNLE 684
Query: 850 KTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEM 909
+ ++ + E+ QTE + LQ + D A ++ L EL +A +++L +
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL-L 743
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
I ++E+ E +R K+E + K A L++L++ +
Sbjct: 744 IAKEEQ-EDLLR-----KRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE 797
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
++ K + + T Q + E+ + +N L G+ +LE+ + +
Sbjct: 798 EATK-NVEVLASRSNTSEQ-----DQAGTEMRVKLLQEENEKLQGRS----EELERRVAQ 847
Query: 1030 IRSKLS--KNDSEFTNEK-NRLQTEIAKLKD--VNAKLEGDKDVFANKYKALENENSNLS 1084
++ ++ K D E + + EI +L++ V+A+ E + V A + ALENE
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR--ALENELEAAQ 905
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD--CMXXXXXXXXXXXXXXXXXXXX 1142
T+E K ++ + S + L+ M +
Sbjct: 906 GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965
Query: 1143 XXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXX 1202
++ ++D+ K K +E+ + +++ + +++ ++ ++ +
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 1203 XXXXXXXXQAVVLANTHRRLSIELTSE---KDELQARFIK-TESKFITLEAEMRDLKADY 1258
+ +L T + L EL ++ KD+ ++R +K E K LE E+ + +
Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD-RSRLVKQMEDKVSQLEMELEEER--- 1081
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
N L I+ ++QL + L Q + D
Sbjct: 1082 -NNSDLLSERISRSREQMEQLRNELLQERAARQD 1114
Score = 58.0 bits (134), Expect = 3e-07
Identities = 140/716 (19%), Positives = 292/716 (40%), Gaps = 74/716 (10%)
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
E + L+R+L+ +KN + + ++ ER LE+ +++H +K+ E + R+
Sbjct: 622 EVAELQRQLQLEVKNQQNIK---EERERMRANLEELRSQHNEKVEE------NSTLQQRL 672
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSS-LTRGGSQED 534
+E E E+ ++ E +++ E + ++ L ++ E RS +G E+
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM-HDELDSAKRSEDREKGALIEE 731
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI---VTCDIHE 591
Q +DLQD L + + + LR E E K D + ++
Sbjct: 732 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 592 -SETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF----HFDLPYLSIFNHMA 646
E+V + +N + A+ + +S++ + + EE + +L
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 647 ANNLRKTAARVEED---NESLLLQLKKMATKARSRKLSPTPPANKLS--IETANDNDEKE 701
+L+ A+ +E E + QL++ AR + L +E A N +
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 911
Query: 702 TDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
T E KL E ++E LRR E+E ++ L K +++L +++ + +
Sbjct: 912 TQEQKQLSEKLKEESEQKEQ--LRRLKNEMENERWHLGKTIEKLQKEMADIVEA------ 963
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
+R S N+L E + K E+ E++++L EK + E+ + L+ + + + +
Sbjct: 964 -SRTSTLELQNQLDEYKEKNRR-ELAEMQRQLKEKTLEAEK--SRLTAMKMQDEMRLMEE 1019
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
L R Q + EA K Q LE + L+ E + LK+ +S R K
Sbjct: 1020 EL-----------RDYQRAQDEALT---KRQLLEQTLKDLEYELEAKSHLKDDRS-RLVK 1064
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
++ K +QLE EL+E E D SE+ R ++++ + L+++
Sbjct: 1065 QME---DKVSQLEMELEE--------ERNNSDLLSERISR----SREQMEQLRNELLQER 1109
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
LKS + S+ R K+ + + ++ ++ + LE E
Sbjct: 1110 AARQDLECDKISLERQNKDLKSRIIHLEGSY--RSSKEGLVVQMEARIAELEDRLESEER 1167
Query: 1002 EMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
+ N LS + + K K L ++D+ L+ + + ++ ++ + ++
Sbjct: 1168 DR----ANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEID 1223
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE K + + + N +L Q ++ ++++ ++ +K+ D+ + L T
Sbjct: 1224 RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLP-SKVLDDMDDDDDLST 1278
Score = 55.6 bits (128), Expect = 2e-06
Identities = 108/525 (20%), Positives = 206/525 (39%), Gaps = 36/525 (6%)
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
+QL+ ++ N K + + E+R Q L ++ +L K E
Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 687
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
K+E Q ++++ L++ K ++ LQ+++ D +
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED--REKGALIEELLQAKQDLQDLLIA 745
Query: 1397 AHDKD--VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+++ ++ ++ EL LKG LK + + + + +LK++Y+ ++ L S+
Sbjct: 746 KEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQALRESVEEATKN 802
Query: 1455 YEELTGKYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
E L + E++ T+ R L E E+ QG +++ ++ +I+ L+ G E
Sbjct: 803 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK---GDE 859
Query: 1512 SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHD 1571
+ A T K + + I L+E L E E+ ++AR E EL AA
Sbjct: 860 AKAKETLK-KYEGEIRQLEEALVHARKE-EKEAVSAR-RALENELEAAQGNLSQTTQEQK 916
Query: 1572 XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
R+ I ++ + E+ +
Sbjct: 917 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISS 1691
Y+ + N R EL + Q+ E + K L A K E++ ++ R ++ +
Sbjct: 977 EYK-EKN--RRELAEMQRQLKEKTLEAE--KSRL-TAMKMQDEMRLMEEELRDYQRA--- 1027
Query: 1692 TDEEEYRNKVALLEQQVACLEDEL-CESRLL--ASKLNTELVSEKSSAEVRLAEMQSRLN 1748
++E K LLEQ + LE EL +S L S+L ++ + S E+ L E ++ +
Sbjct: 1028 --QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSD 1085
Query: 1749 EYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
E +S R ++ L R EL +ER +Q L + +L R
Sbjct: 1086 LLSER--ISRSREQMEQL--RNELL--QERAARQDLECDKISLER 1124
Score = 55.2 bits (127), Expect = 2e-06
Identities = 98/533 (18%), Positives = 214/533 (40%), Gaps = 41/533 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
++++ QE+D L+++ + + + + N++ + + + +V L
Sbjct: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 330 TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENE 389
NE L+ + L +++ +++ ++E EA+ + E L+ L E L+ +
Sbjct: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK--ETLKKYEGEIRQLEEALVHARK 885
Query: 390 DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLE 449
+ K+ + + R +E + + L QT + + LS KLK+ + +QL
Sbjct: 886 EEKEAV------------SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLR 933
Query: 450 QEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPS 509
+ K E E + + G E KE+ V S L LQ +L E K
Sbjct: 934 RLKNEMENERWHL-----GKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE 988
Query: 510 LMKVPQPETVKVSRSSLTRGGSQEDPAQL---LRDLQ----DSLEREADLREQLRNAEEE 562
+ + + +T++ +S LT Q++ + LRD Q ++L + L + L++ E E
Sbjct: 989 MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
Query: 563 -TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + L KQ M D + ++ E NS ++ + S ++
Sbjct: 1049 LEAKSHLKDDRSRLVKQ-MEDKVSQLEMELEEERNNS---DLLSERISRSREQMEQLRNE 1104
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+ + D L N + + E L++Q++ + R S
Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLES 1164
Query: 682 PTPPANKLSIETANDNDEKETDE----ADPAEMKLLLELNEQEATV--LRRKVEELEQDK 735
++ +++ +N E++ E D + L + ++ + ++R+VEE E++
Sbjct: 1165 --EERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEI 1222
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
+ L+ K+L ++ + + + + +L + KVL+D D+
Sbjct: 1223 DRLESSKKKLQRELEE--QMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDD 1273
Score = 50.0 bits (114), Expect = 8e-05
Identities = 85/441 (19%), Positives = 179/441 (40%), Gaps = 39/441 (8%)
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIA---HDKDVKNKDAELATLKGKL----KILEQN 1422
+S + + +E + +L+ ++L ++++ H ++++ +L+ + +L + ++
Sbjct: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 724
Query: 1423 SGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQ 1482
GA + + + KQ+ ++ + E L + ELT L+EE + KEQ
Sbjct: 725 KGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 784
Query: 1483 AQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER 1542
EL +++ + A ++ L + T + TEM+ + LQE E
Sbjct: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQ--DQAGTEMR--VKLLQE---------EN 831
Query: 1543 ARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXX 1602
+L R ++ ER R A +R + + D YE +
Sbjct: 832 EKLQGRSEELER--RVAQLQRQIEDLKGD-----EAKAKETLKKYEGEIRQLEEALVHAR 884
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
+E +A + ++ T T+ + Q++ E Q+ R + E +N +
Sbjct: 885 KEEKEAVSARRALENELEAAQGNLSQT-TQEQKQLSEKLKEESEQKEQLRRLKNEMENER 943
Query: 1663 ----QMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES 1718
+ +E QK MA+I +++ + + +E+ R ++A +++Q+ E +S
Sbjct: 944 WHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 1003
Query: 1719 RLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKER 1778
RL A K+ E+ E L + Q +E +R L + L +E H +
Sbjct: 1004 RLTAMKMQDEM----RLMEEELRDYQRAQDEALTKRQLL--EQTLKDLEYELEAKSHL-K 1056
Query: 1779 DEQQRLLQETSTLARDLRQTL 1799
D++ RL+++ L L
Sbjct: 1057 DDRSRLVKQMEDKVSQLEMEL 1077
>AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein.
Length = 1302
Score = 75.4 bits (177), Expect = 2e-12
Identities = 122/626 (19%), Positives = 266/626 (42%), Gaps = 36/626 (5%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLA 376
EV +LQ+++ + +++++E++ + + E+ S+ + + +Q +E+ +L
Sbjct: 622 EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 681
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
++ E E + E+RDL M D + E +E+ ++ + L
Sbjct: 682 NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQD 741
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
L E + D L K E E L+ + + + +L+++ + ALR E
Sbjct: 742 LLIAKEEQEDLL--RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ-ALRESVEE 798
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
A N + S + + Q T R L QE+ +L ++ R A L+ Q+
Sbjct: 799 ATKNVEVLASRSNTSEQDQAGT--EMRVKLL----QEENEKLQGRSEELERRVAQLQRQI 852
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT--NSIQNKMIHAASTPSSKE 614
+ + + A K+ + + + + +V E E V+ +++N+ + AA S+
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE-LEAAQGNLSQT 911
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
+ LS +K EE++ L L +L KT +++++ +++ + +T
Sbjct: 912 TQEQKQLS-EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD-IVEASRTSTL 969
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-----LELNEQEATVLRRKVE 729
+L N+ + +++T EA+ + + + + L E+E +R +
Sbjct: 970 ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 730 ELEQDKEALKKQVKELTSKI----------SSVTKTSAGSNTTARRSL--TTNSNKLAEE 777
E ++ L++ +K+L ++ S + K + L N++ L E
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R+ ++++++R +L+++ + L + +++ K L KSR + + +
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDL-KSRIIHLEGSYRSSKEGLV 1148
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAKSLRSDKALDLNTKKTTQLENE 896
+E + L + +S E D LQ N++L+ +K D+ L L +K QL
Sbjct: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQK-DQLSLR 1207
Query: 897 LKEALAKIKEL-EMICQDEKSEKKVR 921
LK +++E E I + E S+KK++
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQ 1233
Score = 59.3 bits (137), Expect = 1e-07
Identities = 121/634 (19%), Positives = 261/634 (41%), Gaps = 45/634 (7%)
Query: 676 RSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLLLELNEQEAT-VLRRKVEELEQ 733
R+ SP A K+S++T + ++ + T + + +L + NE+ A +L ++E
Sbjct: 509 RATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGST 568
Query: 734 DKE-ALKKQVKELTSKISSVTKTSAGS---NTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
D + A K++V + KI ++ +AGS N A S T+ L E++ K L E+ E+
Sbjct: 569 DNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS-TSEVKDLLEQKSK-LTIEVAEL 626
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
+++L + ++ + + E + + L + ++N L+++L+ E E
Sbjct: 627 QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKV--EENSTLQQRLEESEGELRKNLE 684
Query: 850 KTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEM 909
+ ++ + E+ QTE + LQ + D A ++ L EL +A +++L +
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL-L 743
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
I ++E+ E +R K+E + K A L++L++ +
Sbjct: 744 IAKEEQ-EDLLR-----KRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE 797
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
++ K + + T Q + E+ + +N L G+ +LE+ + +
Sbjct: 798 EATK-NVEVLASRSNTSEQ-----DQAGTEMRVKLLQEENEKLQGRS----EELERRVAQ 847
Query: 1030 IRSKLS--KNDSEFTNEK-NRLQTEIAKLKD--VNAKLEGDKDVFANKYKALENENSNLS 1084
++ ++ K D E + + EI +L++ V+A+ E + V A + ALENE
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR--ALENELEAAQ 905
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD--CMXXXXXXXXXXXXXXXXXXXX 1142
T+E K ++ + S + L+ M +
Sbjct: 906 GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965
Query: 1143 XXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXX 1202
++ ++D+ K K +E+ + +++ + +++ ++ ++ +
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 1203 XXXXXXXXQAVVLANTHRRLSIELTSE---KDELQARFIK-TESKFITLEAEMRDLKADY 1258
+ +L T + L EL ++ KD+ ++R +K E K LE E+ + +
Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD-RSRLVKQMEDKVSQLEMELEEER--- 1081
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
N L I+ ++QL + L Q + D
Sbjct: 1082 -NNSDLLSERISRSREQMEQLRNELLQERAARQD 1114
Score = 58.0 bits (134), Expect = 3e-07
Identities = 140/716 (19%), Positives = 292/716 (40%), Gaps = 74/716 (10%)
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
E + L+R+L+ +KN + + ++ ER LE+ +++H +K+ E + R+
Sbjct: 622 EVAELQRQLQLEVKNQQNIK---EERERMRANLEELRSQHNEKVEE------NSTLQQRL 672
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSS-LTRGGSQED 534
+E E E+ ++ E +++ E + ++ L ++ E RS +G E+
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM-HDELDSAKRSEDREKGALIEE 731
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI---VTCDIHE 591
Q +DLQD L + + + LR E E K D + ++
Sbjct: 732 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 592 -SETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF----HFDLPYLSIFNHMA 646
E+V + +N + A+ + +S++ + + EE + +L
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 647 ANNLRKTAARVEED---NESLLLQLKKMATKARSRKLSPTPPANKLS--IETANDNDEKE 701
+L+ A+ +E E + QL++ AR + L +E A N +
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 911
Query: 702 TDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
T E KL E ++E LRR E+E ++ L K +++L +++ + +
Sbjct: 912 TQEQKQLSEKLKEESEQKEQ--LRRLKNEMENERWHLGKTIEKLQKEMADIVEA------ 963
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
+R S N+L E + K E+ E++++L EK + E+ + L+ + + + +
Sbjct: 964 -SRTSTLELQNQLDEYKEKNRR-ELAEMQRQLKEKTLEAEK--SRLTAMKMQDEMRLMEE 1019
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
L R Q + EA K Q LE + L+ E + LK+ +S R K
Sbjct: 1020 EL-----------RDYQRAQDEALT---KRQLLEQTLKDLEYELEAKSHLKDDRS-RLVK 1064
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
++ K +QLE EL+E E D SE+ R ++++ + L+++
Sbjct: 1065 QME---DKVSQLEMELEE--------ERNNSDLLSERISR----SREQMEQLRNELLQER 1109
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
LKS + S+ R K+ + + ++ ++ + LE E
Sbjct: 1110 AARQDLECDKISLERQNKDLKSRIIHLEGSY--RSSKEGLVVQMEARIAELEDRLESEER 1167
Query: 1002 EMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
+ N LS + + K K L ++D+ L+ + + ++ ++ + ++
Sbjct: 1168 DR----ANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEID 1223
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+LE K + + + N +L Q ++ ++++ ++ +K+ D+ + L T
Sbjct: 1224 RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLP-SKVLDDMDDDDDLST 1278
Score = 55.6 bits (128), Expect = 2e-06
Identities = 108/525 (20%), Positives = 206/525 (39%), Gaps = 36/525 (6%)
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
+QL+ ++ N K + + E+R Q L ++ +L K E
Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 687
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
K+E Q ++++ L++ K ++ LQ+++ D +
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED--REKGALIEELLQAKQDLQDLLIA 745
Query: 1397 AHDKD--VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+++ ++ ++ EL LKG LK + + + + +LK++Y+ ++ L S+
Sbjct: 746 KEEQEDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQALRESVEEATKN 802
Query: 1455 YEELTGKYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
E L + E++ T+ R L E E+ QG +++ ++ +I+ L+ G E
Sbjct: 803 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK---GDE 859
Query: 1512 SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHD 1571
+ A T K + + I L+E L E E+ ++AR E EL AA
Sbjct: 860 AKAKETLK-KYEGEIRQLEEALVHARKE-EKEAVSAR-RALENELEAAQGNLSQTTQEQK 916
Query: 1572 XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
R+ I ++ + E+ +
Sbjct: 917 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISS 1691
Y+ + N R EL + Q+ E + K L A K E++ ++ R ++ +
Sbjct: 977 EYK-EKN--RRELAEMQRQLKEKTLEAE--KSRL-TAMKMQDEMRLMEEELRDYQRA--- 1027
Query: 1692 TDEEEYRNKVALLEQQVACLEDEL-CESRLL--ASKLNTELVSEKSSAEVRLAEMQSRLN 1748
++E K LLEQ + LE EL +S L S+L ++ + S E+ L E ++ +
Sbjct: 1028 --QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSD 1085
Query: 1749 EYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
E +S R ++ L R EL +ER +Q L + +L R
Sbjct: 1086 LLSER--ISRSREQMEQL--RNELL--QERAARQDLECDKISLER 1124
Score = 55.2 bits (127), Expect = 2e-06
Identities = 98/533 (18%), Positives = 214/533 (40%), Gaps = 41/533 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
++++ QE+D L+++ + + + + N++ + + + +V L
Sbjct: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 330 TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENE 389
NE L+ + L +++ +++ ++E EA+ + E L+ L E L+ +
Sbjct: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK--ETLKKYEGEIRQLEEALVHARK 885
Query: 390 DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLE 449
+ K+ + + R +E + + L QT + + LS KLK+ + +QL
Sbjct: 886 EEKEAV------------SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLR 933
Query: 450 QEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPS 509
+ K E E + + G E KE+ V S L LQ +L E K
Sbjct: 934 RLKNEMENERWHL-----GKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE 988
Query: 510 LMKVPQPETVKVSRSSLTRGGSQEDPAQL---LRDLQ----DSLEREADLREQLRNAEEE 562
+ + + +T++ +S LT Q++ + LRD Q ++L + L + L++ E E
Sbjct: 989 MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
Query: 563 -TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + L KQ M D + ++ E NS ++ + S ++
Sbjct: 1049 LEAKSHLKDDRSRLVKQ-MEDKVSQLEMELEEERNNS---DLLSERISRSREQMEQLRNE 1104
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+ + D L N + + E L++Q++ + R S
Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLES 1164
Query: 682 PTPPANKLSIETANDNDEKETDE----ADPAEMKLLLELNEQEATV--LRRKVEELEQDK 735
++ +++ +N E++ E D + L + ++ + ++R+VEE E++
Sbjct: 1165 --EERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEI 1222
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
+ L+ K+L ++ + + + + +L + KVL+D D+
Sbjct: 1223 DRLESSKKKLQRELEE--QMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDD 1273
Score = 50.0 bits (114), Expect = 8e-05
Identities = 85/441 (19%), Positives = 179/441 (40%), Gaps = 39/441 (8%)
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIA---HDKDVKNKDAELATLKGKL----KILEQN 1422
+S + + +E + +L+ ++L ++++ H ++++ +L+ + +L + ++
Sbjct: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 724
Query: 1423 SGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQ 1482
GA + + + KQ+ ++ + E L + ELT L+EE + KEQ
Sbjct: 725 KGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 784
Query: 1483 AQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER 1542
EL +++ + A ++ L + T + TEM+ + LQE E
Sbjct: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQ--DQAGTEMR--VKLLQE---------EN 831
Query: 1543 ARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXX 1602
+L R ++ ER R A +R + + D YE +
Sbjct: 832 EKLQGRSEELER--RVAQLQRQIEDLKGD-----EAKAKETLKKYEGEIRQLEEALVHAR 884
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
+E +A + ++ T T+ + Q++ E Q+ R + E +N +
Sbjct: 885 KEEKEAVSARRALENELEAAQGNLSQT-TQEQKQLSEKLKEESEQKEQLRRLKNEMENER 943
Query: 1663 ----QMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES 1718
+ +E QK MA+I +++ + + +E+ R ++A +++Q+ E +S
Sbjct: 944 WHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 1003
Query: 1719 RLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKER 1778
RL A K+ E+ E L + Q +E +R L + L +E H +
Sbjct: 1004 RLTAMKMQDEM----RLMEEELRDYQRAQDEALTKRQLL--EQTLKDLEYELEAKSHL-K 1056
Query: 1779 DEQQRLLQETSTLARDLRQTL 1799
D++ RL+++ L L
Sbjct: 1057 DDRSRLVKQMEDKVSQLEMEL 1077
>AL137068-5|CAI12358.1| 1773|Homo sapiens centrosomal protein 110kDa
protein.
Length = 1773
Score = 75.4 bits (177), Expect = 2e-12
Identities = 177/877 (20%), Positives = 357/877 (40%), Gaps = 97/877 (11%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ + ++E L +D L + + +E E + L R K + E L + ++
Sbjct: 798 RQSEKEMEELHHNIDDLLQEKKSLECEVEE--LHRTVQKRQQQKDFIDGNVESLMTELEI 855
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
+ H+ED+ DE + + + + + SEL EA R + + ++L + + ++
Sbjct: 856 EKSLKHHEDIVDEIECIEKTLLKRRSELR-----EAD-RLLAEAESELSCTKEKTKNAVE 909
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ D K+ L E A+E L R ++T N +L+ + A
Sbjct: 910 KFTDAKRSLLQ------------TESDAEE---LERRAQETAVNLVKADQQLRSLQADAK 954
Query: 447 QLEQEKAEHE---KKLLEIVGGPDG-----MQRENRIKELEQEVARSTEVALRLQ----R 494
LEQ K + E K++ +IV D +++ ++ E Q++ + E+A R + +
Sbjct: 955 DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ 1014
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSL--TRGGSQEDPAQLLRDLQDSLEREADL 552
L E+ L K+ T + ++ + G +++ LL+ ++ +ADL
Sbjct: 1015 VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG--SMVQAKADL 1072
Query: 553 REQLRNAEEE-TANCKQVNP-PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+E LR E E T C + + L++ + I E +T I+ ++
Sbjct: 1073 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI------- 1125
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
KE+ + + + +T+ L L + NH + RV E ++ Q+
Sbjct: 1126 -EKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKT---QVAV 1181
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ K L K IE +K+ E D E +E E+ L+ VE
Sbjct: 1182 LEEKLELENLQQISQQQKGEIEW-----QKQLLERDKRE----IERMTAESRALQSCVEC 1232
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
L ++KE L+++ K++ + A + ++ +N KL E V+ L+ E+D++
Sbjct: 1233 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKME-QSNLEKL-ELNVRKLQQELDQL- 1289
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
RD LH ++S Q++ + K ++++ ++ +++ L + +Q+
Sbjct: 1290 ------NRDKLSLHNDISAMQQQLQE--KREAVNSLQEELANVQDHLNLAKQDLLHTTKH 1341
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
L ++ +LQ K + N + K + ++ L+NE++E K+ + EM+
Sbjct: 1342 QDVLLSEQTRLQ---KDISEWAN-RFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMM 1397
Query: 911 CQDEKSEKKVRFTEATKKETD--TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
Q + E++ +E +K ET TLK +Q +
Sbjct: 1398 FQRLQKERE---SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 1454
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAG--------LSGKEMTAK 1020
Q+ + + T TK QL + + L + GE+ + K A L + +T +
Sbjct: 1455 QEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER 1514
Query: 1021 TKLEKEIDEI-------RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K EK++ + RS+L KN E E + +Q E+A ++ V +
Sbjct: 1515 KKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKEL 1574
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
++ E + L Q ++++ R+ +I+ LK+
Sbjct: 1575 NQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS 1610
Score = 54.0 bits (124), Expect = 5e-06
Identities = 153/869 (17%), Positives = 355/869 (40%), Gaps = 59/869 (6%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVL 320
S ++E + + E+ +++ + ++ +D LL+ ++ + + + ++
Sbjct: 881 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 940
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST-EAQTRQIEQLRAKLLAAET 379
K Q++ L +DL K + ++EI + + S + +++ E+L +L +
Sbjct: 941 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 1000
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
E + + NED L+ L +Q E + + ++ E + + R L K +
Sbjct: 1001 DIE-MAERNED--HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLD-RQLGHKKE 1056
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEA 499
+ + Q KA+ ++ L +G + ++ N I+E++ + + L +++E
Sbjct: 1057 ELHLLQGSMVQAKADLQEALR--LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER 1114
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
++ T + K + E ++V +++ ++ L+++ D L+ E + L+
Sbjct: 1115 KTQLTLIKQEIEK--EEENLQVVLRQMSKHKTE------LKNILDMLQLENHELQGLKLQ 1166
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
++ + + L++++ +N+ I + + Q +++ + ++S
Sbjct: 1167 HDQRVSELEKTQVAVLEEKLELENLQ--QISQQQKGEIEWQKQLLERDKREIERMTAESR 1224
Query: 620 PLS-----IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
L + K E+ Q D I+ A R AA EE+++ L+K+
Sbjct: 1225 ALQSCVECLSKEKEDLQEKCD-----IWEKKLAQTKRVLAA-AEENSKMEQSNLEKLELN 1278
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
R + N+ + ND + + E + L E+ A V + L
Sbjct: 1279 VRKLQ-QELDQLNRDKLSLHNDISAMQQQLQEKREA--VNSLQEELANVQ----DHLNLA 1331
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARR-SLTTNSNKLAEERVKVLEDEIDEVRKKL 793
K+ L K +S T+ + A R + +++++VL++EI+E + KL
Sbjct: 1332 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1391
Query: 794 IEKERDCERLHAELSLAQKKPKT--LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+++E +RL E + K +T + +++ D K +L + + +
Sbjct: 1392 VQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV 1451
Query: 852 QSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK-KTTQLENELKEALAKIKELEMI 910
++L+ + ++ K L K S R + ++ + + Q E + A + + +
Sbjct: 1452 RTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFL 1511
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ +K+EK+V A+ KE LK ++ AT++ + D +
Sbjct: 1512 TERKKAEKQV----ASLKE--ALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHE 1565
Query: 971 SFKPRIPKKPTDLTTK-LQLKKMV---EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
+ R+ K+ + + +LKK + +DLE E+ M+ K+ +T L K
Sbjct: 1566 RAR-RLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKD-EIRTSL-KN 1622
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+++ +L + L+ E+ LK+ N ++ F K + + +
Sbjct: 1623 LNQFLPELPADLEAILERNENLEGELESLKE-NLPFTMNEGPFEEKLNFSQVHIMDEHWR 1681
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+ L E++++RE ++L A L++ S Q
Sbjct: 1682 GEALREKLRHRE---DRLKAQLRHCMSKQ 1707
Score = 52.4 bits (120), Expect = 2e-05
Identities = 120/592 (20%), Positives = 222/592 (37%), Gaps = 75/592 (12%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQ 1285
L+ EK++LQ + E K L R L A EN +S + ++++++L+ L Q
Sbjct: 1233 LSKEKEDLQEKCDIWEKK---LAQTKRVLAAAEENSKME-QSNLEKLELNVRKLQQELDQ 1288
Query: 1286 TTNDKY----DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
DK D + ++ E R QD LN AK L T E
Sbjct: 1289 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1348
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE--------------LDTDLQSE 1387
+L+ D+++ N +N+ +E L + +SE
Sbjct: 1349 QTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE 1408
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
KL+ ++ + + EL K KL + A +R+ L QE E + LE +
Sbjct: 1409 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL-QEEERWCESLEKT 1467
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
L+ K + E E+ +V K+ GELL +QKE + + L+ +
Sbjct: 1468 LSQTKRQLSE--------REQQLVEKS----------GELLALQKEADSMRADFSLLRNQ 1509
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+ TE+ + + +ASL+E L +++R++L L ++++E +E
Sbjct: 1510 -------FLTERKKAEKQVASLKEAL-----KIQRSQLEKNLLEQKQENSCIQKEMATIE 1557
Query: 1568 ----HHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
+H+ +Y + K I + + K
Sbjct: 1558 LVAQDNHERARRLMKELNQMQYEYTELKK--------QMANQKDLERRQMEISDAMRTLK 1609
Query: 1624 AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN-GDKSA 1682
+E+ D + + L L + +N + LE+ ++++ N G
Sbjct: 1610 SEVKD---EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEE 1666
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDEL-CESRLLASKLNTELVSEKSSAEVRLA 1741
+++ + + D E +R + L +++ ED L + R SK L+ K E L
Sbjct: 1667 KLNFSQVHIMD-EHWRGEA--LREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLH 1723
Query: 1742 EMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
++ +++ E L++S A A + +L D Q QE + AR
Sbjct: 1724 SLRRQVDALGE--LVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 1773
Score = 50.8 bits (116), Expect = 5e-05
Identities = 103/586 (17%), Positives = 237/586 (40%), Gaps = 55/586 (9%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAAKDVHIKQLED 1281
EL E +K + + +L+A+ +DL K E + + +AAKD + L
Sbjct: 927 ELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSK 986
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
+ T ++ + +EM E ++E ++ ++ L+++E A + E
Sbjct: 987 KKEKLT-EELQKLQKDIEMAE---------------RNEDHHLQV-LKESEVLLQAKRAE 1029
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIA---- 1397
+ +LKS + + + + DLQ E +L +
Sbjct: 1030 LEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ-EALRLGETEVTEKCN 1088
Query: 1398 HDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEE 1457
H ++VK+ EL+ KG+L + ++T +KQE E+ + L+ L E
Sbjct: 1089 HIREVKSLLEELSFQKGELNV---QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1145
Query: 1458 LTGKYELLEEEHVVTKARLTVEKEQAQG-ELLHVQKELSTALGEIKTLQEKLGTESAAWN 1516
L ++L+ +E + QG +L H Q+ ++ L+EKL E+
Sbjct: 1146 LKNILDMLQ-----------LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQI 1194
Query: 1517 TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXX 1576
++ + + I ++ L E+ER +R Q E + ++ L+ D
Sbjct: 1195 SQ--QQKGEIEWQKQLLERDKREIERMTAESRALQSCVE--CLSKEKEDLQEKCDIWEKK 1250
Query: 1577 XXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQ 1636
E SK+++ + + + + +I+ + + + +
Sbjct: 1251 LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK 1310
Query: 1637 ---MNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTD 1693
+N++++EL ++ + ++ +++ + + + ++ D S +R +
Sbjct: 1311 REAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQK-DISEWANRFEDCQKE 1369
Query: 1694 EEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
EE + ++ +L+ ++ + +L + ++ +L E SE+S E ++ + ++ E+E
Sbjct: 1370 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1429
Query: 1754 RLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
L+ ++++ + +++ A +E+ R LQE L +TL
Sbjct: 1430 --LTDQKSKLDQVLSKVLAA-----EERVRTLQEEERWCESLEKTL 1468
Score = 48.4 bits (110), Expect = 3e-04
Identities = 82/338 (24%), Positives = 148/338 (43%), Gaps = 55/338 (16%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANI----DTANKYTTGR--SSEVLK---- 321
Q G +Q++DI+ K+ +++E +IL R D + T G+ ++E LK
Sbjct: 4 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLE 63
Query: 322 -----LQQKVNELT-----THNE--DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ 369
LQ+ + + NE LRDEK+ L Q++ E+E E R E E
Sbjct: 64 GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQE---RDQLEIVAMDAEN 120
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
+R +L E+ +E + N +++ DL ++ A E + L+ ELE+ +
Sbjct: 121 MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDA-EANQLKEELEKVTR 179
Query: 430 NCRV----LSFKLKKTERKA-----------DQLEQEKAEHEKKLLEIVGGPDGMQR--- 471
++ L +L+K ER+A ++ EQE +E KL + + +++
Sbjct: 180 LTQLEQSALQAELEK-ERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLK 238
Query: 472 --ENRIKELEQEVARSTEVALR---LQRELAEANSKFTGSNPS-LMKVPQPETVKVSRSS 525
+N + + + R EVA R L+R+L + +PS ++ + K
Sbjct: 239 DFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI 298
Query: 526 LTRGGSQEDPAQLL-RDLQDSLEREADLREQLRNAEEE 562
L R + D AQ+ R LQ+ + + +E+L +EE
Sbjct: 299 LARSKWERDEAQVRERKLQEEMALQ---QEKLATGQEE 333
Score = 47.6 bits (108), Expect = 5e-04
Identities = 82/464 (17%), Positives = 164/464 (35%), Gaps = 19/464 (4%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRD--------LKADYENKITSLESTIAAKDVHI 1276
+L S DE+ +R K + LE ++ + LK D E I+ L+ +
Sbjct: 21 QLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQA 80
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL-EKTEAES 1335
Q ++ R+ ++K E+ + R + EL + L E+ E +
Sbjct: 81 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 140
Query: 1336 SAAKLE--MAQLKSDL-AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD 1392
S + + ++ +++L A+L + + + L +L+ ER+ L
Sbjct: 141 SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL- 199
Query: 1393 RMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ + + + K+ E + L KLK L+ ++ +++ + + V L +
Sbjct: 200 KNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVA- 258
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQA--QGELLHVQKELSTALGEIKTLQEKLGT 1510
A +EL K +L E + + K A Q + + E + + KL
Sbjct: 259 ARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQE 318
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHH 1570
E A + Q ER ++ + AR+ Q E E+ + +E
Sbjct: 319 EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSME--- 375
Query: 1571 DXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTK 1630
+ + ER+ R +++ K K + +
Sbjct: 376 EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 435
Query: 1631 TRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAE 1674
++ +D+LKSLH V + +ER Q E + A+
Sbjct: 436 KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQ 479
Score = 44.8 bits (101), Expect = 0.003
Identities = 76/411 (18%), Positives = 174/411 (42%), Gaps = 38/411 (9%)
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
MK EQ+ ++ ++ ++LE + + ++ + T +I + + A +L
Sbjct: 1 MKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEAL-- 58
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
K E + L++ + ++ + + + +C +L E +TL+ + L +Q+
Sbjct: 59 --KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE-------KETLL--QRLTEVEQE 107
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK---NAKSLRSDKALDLN 886
+ QL+++ +A +R + LE+ ++ N LQ + +A + L+L
Sbjct: 108 ----RDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLR 163
Query: 887 TKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
+ QL+ EL E + ++ +LE + EK+ + + + + K+
Sbjct: 164 DAEANQLKEEL-EKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAK 222
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVV 1006
+ LK ++ + +P ++ ++ ++ L+ GEM +
Sbjct: 223 LKHLQDDNNLLKQQLKDFQNHLNHVVDGLV--RPEEVAARVD--ELRRKLKLGTGEMN-I 277
Query: 1007 MKNAGLSGKEMTAKTKLEKEIDEI--RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ + GK + L+K+ EI RSK +++++ K LQ E+A ++ A G
Sbjct: 278 HSPSDVLGKSL---ADLQKQFSEILARSKWERDEAQVRERK--LQEEMALQQEKLA--TG 330
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
++ +ALE + Q + ++M+N +I+ L +LK+ +Q
Sbjct: 331 QEEFRQACERALEARMNFDKRQHEARIQQMEN---EIHYLQENLKSMEEIQ 378
Score = 39.1 bits (87), Expect = 0.16
Identities = 49/230 (21%), Positives = 98/230 (42%), Gaps = 12/230 (5%)
Query: 715 ELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSAGSNTTARRSLT 768
E EQE + L K++ L+ D LK+Q+K+ + ++ V + A RR L
Sbjct: 210 EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 269
Query: 769 TNSNKL-AEERVKVLEDEIDEVRKKLIE--KERDCERLHAELSLAQKKPKTLIKSRSLDA 825
+ ++ VL + +++K+ E ER A++ + + + ++ L
Sbjct: 270 LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLAT 329
Query: 826 SDQQ-NVDLKRQLQV-IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKAL 883
++ +R L+ + + A+ Q +E + LQ K ++ ++ L+ +A
Sbjct: 330 GQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEAD 389
Query: 884 DLNTKKTTQL-ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+ + QL E E K+ L K E + +K KK++ AT + T
Sbjct: 390 EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT 439
Score = 36.3 bits (80), Expect = 1.1
Identities = 60/326 (18%), Positives = 127/326 (38%), Gaps = 12/326 (3%)
Query: 1219 HRRLSIELTSEKDELQ-ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK---DV 1274
H L E++ +D +Q + K E ++ + A R + + E +++ + K +
Sbjct: 766 HHNLENEVSRLEDIMQHLKSKKREERW--MRASKRQSEKEMEELHHNIDDLLQEKKSLEC 823
Query: 1275 HIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAE 1334
+++L +++ K D VE + DE+ + L K +E
Sbjct: 824 EVEELHRTVQKRQQQK-DFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 882
Query: 1335 SSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM 1394
A +A+ +S+L+ + E+ A+EL+ Q L
Sbjct: 883 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL--- 939
Query: 1395 RIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+ D+ +++ A+ L+ + KI ++ +I K + + K + L E +
Sbjct: 940 -VKADQQLRSLQADAKDLE-QHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK 997
Query: 1455 YEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAA 1514
++ E E+ H+ V + + EL ++ ++++ E+ L +LG +
Sbjct: 998 LQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEE 1057
Query: 1515 WNTEKTEMQNSIASLQERLCGGGWEV 1540
+ + M + A LQE L G EV
Sbjct: 1058 LHLLQGSMVQAKADLQEALRLGETEV 1083
Score = 35.9 bits (79), Expect = 1.5
Identities = 123/777 (15%), Positives = 302/777 (38%), Gaps = 57/777 (7%)
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP-------KTLIKSRSL 823
S + +E+ ++ L ID++ ++ E + E LH + Q++ ++L+ +
Sbjct: 796 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEI 855
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK---KLQLLKNA--KSLR 878
+ S + + D+ +++ IE+ ++L+ +++ EAD + E++ + KNA K
Sbjct: 856 EKSLKHHEDIVDEIECIEK--TLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTD 913
Query: 879 SDKALDLNTKKTTQLENELKEALAKI----KELEMICQDEK--SEKKVRFTEATKKETDT 932
+ ++L +LE +E + ++L + D K + K++ E K+
Sbjct: 914 AKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKI 973
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
+ +K Q ++ + + + + + +L+K+
Sbjct: 974 VAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKL 1033
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
+ + EM V+ + G +E+ + + + +++ L ++E T + N ++ E
Sbjct: 1034 KSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR-E 1092
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
+ L + + +G+ +V ++ K + + + + + E ++ Q++K +LKN
Sbjct: 1093 VKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1149
Query: 1112 TSL----QTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN---KLLKEVG 1164
+ + +++N +I Q + + K++
Sbjct: 1150 LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1209
Query: 1165 DKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI 1224
++ K+ + C +E ++D VLA +
Sbjct: 1210 ERDKREIERMTAESRALQSC--VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM 1267
Query: 1225 ELTS-EKDELQARFIKTE-----SKFITLEAEMRDLKADYENK---ITSLESTIAAKDVH 1275
E ++ EK EL R ++ E ++L ++ ++ + K + SL+ +A H
Sbjct: 1268 EQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDH 1327
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
+ + L TT + D S E ++ Q E + +L+ + E
Sbjct: 1328 LNLAKQDLLHTTKHQ-DVLLS--EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI 1384
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
KL++ Q + +L+ + + +L+ +L ++ KLD++
Sbjct: 1385 EENKLKLVQQEMMFQRLQKERESEESKLETSKVT---LKEQQHQLEKELTDQKSKLDQVL 1441
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+A ++ V+ E + K L Q ++R +L ++ E + L+ +
Sbjct: 1442 SKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELL-ALQKEADSMR 1500
Query: 1453 AEYEELTGKY----ELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
A++ L ++ + E++ K L +++ Q + LL ++E S E+ T++
Sbjct: 1501 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE 1557
>AL137068-2|CAM13285.1| 2325|Homo sapiens centrosomal protein 110kDa
protein.
Length = 2325
Score = 75.4 bits (177), Expect = 2e-12
Identities = 177/877 (20%), Positives = 357/877 (40%), Gaps = 97/877 (11%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ + ++E L +D L + + +E E + L R K + E L + ++
Sbjct: 1350 RQSEKEMEELHHNIDDLLQEKKSLECEVEE--LHRTVQKRQQQKDFIDGNVESLMTELEI 1407
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
+ H+ED+ DE + + + + + SEL EA R + + ++L + + ++
Sbjct: 1408 EKSLKHHEDIVDEIECIEKTLLKRRSELR-----EAD-RLLAEAESELSCTKEKTKNAVE 1461
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ D K+ L E A+E L R ++T N +L+ + A
Sbjct: 1462 KFTDAKRSLLQ------------TESDAEE---LERRAQETAVNLVKADQQLRSLQADAK 1506
Query: 447 QLEQEKAEHE---KKLLEIVGGPDG-----MQRENRIKELEQEVARSTEVALRLQ----R 494
LEQ K + E K++ +IV D +++ ++ E Q++ + E+A R + +
Sbjct: 1507 DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ 1566
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSL--TRGGSQEDPAQLLRDLQDSLEREADL 552
L E+ L K+ T + ++ + G +++ LL+ ++ +ADL
Sbjct: 1567 VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG--SMVQAKADL 1624
Query: 553 REQLRNAEEE-TANCKQVNP-PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+E LR E E T C + + L++ + I E +T I+ ++
Sbjct: 1625 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI------- 1677
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
KE+ + + + +T+ L L + NH + RV E ++ Q+
Sbjct: 1678 -EKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKT---QVAV 1733
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ K L K IE +K+ E D E +E E+ L+ VE
Sbjct: 1734 LEEKLELENLQQISQQQKGEIEW-----QKQLLERDKRE----IERMTAESRALQSCVEC 1784
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
L ++KE L+++ K++ + A + ++ +N KL E V+ L+ E+D++
Sbjct: 1785 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKME-QSNLEKL-ELNVRKLQQELDQL- 1841
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
RD LH ++S Q++ + K ++++ ++ +++ L + +Q+
Sbjct: 1842 ------NRDKLSLHNDISAMQQQLQE--KREAVNSLQEELANVQDHLNLAKQDLLHTTKH 1893
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
L ++ +LQ K + N + K + ++ L+NE++E K+ + EM+
Sbjct: 1894 QDVLLSEQTRLQ---KDISEWAN-RFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMM 1949
Query: 911 CQDEKSEKKVRFTEATKKETD--TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
Q + E++ +E +K ET TLK +Q +
Sbjct: 1950 FQRLQKERE---SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAG--------LSGKEMTAK 1020
Q+ + + T TK QL + + L + GE+ + K A L + +T +
Sbjct: 2007 QEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER 2066
Query: 1021 TKLEKEIDEI-------RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K EK++ + RS+L KN E E + +Q E+A ++ V +
Sbjct: 2067 KKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKEL 2126
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
++ E + L Q ++++ R+ +I+ LK+
Sbjct: 2127 NQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS 2162
Score = 54.0 bits (124), Expect = 5e-06
Identities = 153/869 (17%), Positives = 355/869 (40%), Gaps = 59/869 (6%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVL 320
S ++E + + E+ +++ + ++ +D LL+ ++ + + + ++
Sbjct: 1433 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 1492
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST-EAQTRQIEQLRAKLLAAET 379
K Q++ L +DL K + ++EI + + S + +++ E+L +L +
Sbjct: 1493 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 1552
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
E + + NED L+ L +Q E + + ++ E + + R L K +
Sbjct: 1553 DIE-MAERNED--HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLD-RQLGHKKE 1608
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEA 499
+ + Q KA+ ++ L +G + ++ N I+E++ + + L +++E
Sbjct: 1609 ELHLLQGSMVQAKADLQEALR--LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER 1666
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
++ T + K + E ++V +++ ++ L+++ D L+ E + L+
Sbjct: 1667 KTQLTLIKQEIEK--EEENLQVVLRQMSKHKTE------LKNILDMLQLENHELQGLKLQ 1718
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
++ + + L++++ +N+ I + + Q +++ + ++S
Sbjct: 1719 HDQRVSELEKTQVAVLEEKLELENLQ--QISQQQKGEIEWQKQLLERDKREIERMTAESR 1776
Query: 620 PLS-----IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
L + K E+ Q D I+ A R AA EE+++ L+K+
Sbjct: 1777 ALQSCVECLSKEKEDLQEKCD-----IWEKKLAQTKRVLAA-AEENSKMEQSNLEKLELN 1830
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
R + N+ + ND + + E + L E+ A V + L
Sbjct: 1831 VRKLQ-QELDQLNRDKLSLHNDISAMQQQLQEKREA--VNSLQEELANVQ----DHLNLA 1883
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARR-SLTTNSNKLAEERVKVLEDEIDEVRKKL 793
K+ L K +S T+ + A R + +++++VL++EI+E + KL
Sbjct: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1943
Query: 794 IEKERDCERLHAELSLAQKKPKT--LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+++E +RL E + K +T + +++ D K +L + + +
Sbjct: 1944 VQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV 2003
Query: 852 QSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK-KTTQLENELKEALAKIKELEMI 910
++L+ + ++ K L K S R + ++ + + Q E + A + + +
Sbjct: 2004 RTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFL 2063
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ +K+EK+V A+ KE LK ++ AT++ + D +
Sbjct: 2064 TERKKAEKQV----ASLKE--ALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHE 2117
Query: 971 SFKPRIPKKPTDLTTK-LQLKKMV---EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
+ R+ K+ + + +LKK + +DLE E+ M+ K+ +T L K
Sbjct: 2118 RAR-RLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKD-EIRTSL-KN 2174
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+++ +L + L+ E+ LK+ N ++ F K + + +
Sbjct: 2175 LNQFLPELPADLEAILERNENLEGELESLKE-NLPFTMNEGPFEEKLNFSQVHIMDEHWR 2233
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+ L E++++RE ++L A L++ S Q
Sbjct: 2234 GEALREKLRHRE---DRLKAQLRHCMSKQ 2259
Score = 52.4 bits (120), Expect = 2e-05
Identities = 120/592 (20%), Positives = 222/592 (37%), Gaps = 75/592 (12%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQ 1285
L+ EK++LQ + E K L R L A EN +S + ++++++L+ L Q
Sbjct: 1785 LSKEKEDLQEKCDIWEKK---LAQTKRVLAAAEENSKME-QSNLEKLELNVRKLQQELDQ 1840
Query: 1286 TTNDKY----DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
DK D + ++ E R QD LN AK L T E
Sbjct: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE--------------LDTDLQSE 1387
+L+ D+++ N +N+ +E L + +SE
Sbjct: 1901 QTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE 1960
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
KL+ ++ + + EL K KL + A +R+ L QE E + LE +
Sbjct: 1961 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL-QEEERWCESLEKT 2019
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
L+ K + E E+ +V K+ GELL +QKE + + L+ +
Sbjct: 2020 LSQTKRQLSE--------REQQLVEKS----------GELLALQKEADSMRADFSLLRNQ 2061
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+ TE+ + + +ASL+E L +++R++L L ++++E +E
Sbjct: 2062 -------FLTERKKAEKQVASLKEAL-----KIQRSQLEKNLLEQKQENSCIQKEMATIE 2109
Query: 1568 ----HHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
+H+ +Y + K I + + K
Sbjct: 2110 LVAQDNHERARRLMKELNQMQYEYTELKK--------QMANQKDLERRQMEISDAMRTLK 2161
Query: 1624 AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN-GDKSA 1682
+E+ D + + L L + +N + LE+ ++++ N G
Sbjct: 2162 SEVKD---EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEE 2218
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDEL-CESRLLASKLNTELVSEKSSAEVRLA 1741
+++ + + D E +R + L +++ ED L + R SK L+ K E L
Sbjct: 2219 KLNFSQVHIMD-EHWRGEA--LREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLH 2275
Query: 1742 EMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
++ +++ E L++S A A + +L D Q QE + AR
Sbjct: 2276 SLRRQVDALGE--LVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325
Score = 50.8 bits (116), Expect = 5e-05
Identities = 103/586 (17%), Positives = 237/586 (40%), Gaps = 55/586 (9%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAAKDVHIKQLED 1281
EL E +K + + +L+A+ +DL K E + + +AAKD + L
Sbjct: 1479 ELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSK 1538
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
+ T ++ + +EM E ++E ++ ++ L+++E A + E
Sbjct: 1539 KKEKLT-EELQKLQKDIEMAE---------------RNEDHHLQV-LKESEVLLQAKRAE 1581
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIA---- 1397
+ +LKS + + + + DLQ E +L +
Sbjct: 1582 LEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ-EALRLGETEVTEKCN 1640
Query: 1398 HDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEE 1457
H ++VK+ EL+ KG+L + ++T +KQE E+ + L+ L E
Sbjct: 1641 HIREVKSLLEELSFQKGELNV---QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1697
Query: 1458 LTGKYELLEEEHVVTKARLTVEKEQAQG-ELLHVQKELSTALGEIKTLQEKLGTESAAWN 1516
L ++L+ +E + QG +L H Q+ ++ L+EKL E+
Sbjct: 1698 LKNILDMLQ-----------LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQI 1746
Query: 1517 TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXX 1576
++ + + I ++ L E+ER +R Q E + ++ L+ D
Sbjct: 1747 SQ--QQKGEIEWQKQLLERDKREIERMTAESRALQSCVE--CLSKEKEDLQEKCDIWEKK 1802
Query: 1577 XXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQ 1636
E SK+++ + + + + +I+ + + + +
Sbjct: 1803 LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK 1862
Query: 1637 ---MNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTD 1693
+N++++EL ++ + ++ +++ + + + ++ D S +R +
Sbjct: 1863 REAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQK-DISEWANRFEDCQKE 1921
Query: 1694 EEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
EE + ++ +L+ ++ + +L + ++ +L E SE+S E ++ + ++ E+E
Sbjct: 1922 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1981
Query: 1754 RLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
L+ ++++ + +++ A +E+ R LQE L +TL
Sbjct: 1982 --LTDQKSKLDQVLSKVLAA-----EERVRTLQEEERWCESLEKTL 2020
Score = 48.4 bits (110), Expect = 3e-04
Identities = 82/338 (24%), Positives = 148/338 (43%), Gaps = 55/338 (16%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANI----DTANKYTTGR--SSEVLK---- 321
Q G +Q++DI+ K+ +++E +IL R D + T G+ ++E LK
Sbjct: 556 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLE 615
Query: 322 -----LQQKVNELT-----THNE--DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ 369
LQ+ + + NE LRDEK+ L Q++ E+E E R E E
Sbjct: 616 GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQE---RDQLEIVAMDAEN 672
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
+R +L E+ +E + N +++ DL ++ A E + L+ ELE+ +
Sbjct: 673 MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDA-EANQLKEELEKVTR 731
Query: 430 NCRV----LSFKLKKTERKA-----------DQLEQEKAEHEKKLLEIVGGPDGMQR--- 471
++ L +L+K ER+A ++ EQE +E KL + + +++
Sbjct: 732 LTQLEQSALQAELEK-ERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLK 790
Query: 472 --ENRIKELEQEVARSTEVALR---LQRELAEANSKFTGSNPS-LMKVPQPETVKVSRSS 525
+N + + + R EVA R L+R+L + +PS ++ + K
Sbjct: 791 DFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI 850
Query: 526 LTRGGSQEDPAQLL-RDLQDSLEREADLREQLRNAEEE 562
L R + D AQ+ R LQ+ + + +E+L +EE
Sbjct: 851 LARSKWERDEAQVRERKLQEEMALQ---QEKLATGQEE 885
Score = 47.6 bits (108), Expect = 5e-04
Identities = 82/464 (17%), Positives = 164/464 (35%), Gaps = 19/464 (4%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRD--------LKADYENKITSLESTIAAKDVHI 1276
+L S DE+ +R K + LE ++ + LK D E I+ L+ +
Sbjct: 573 QLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQA 632
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL-EKTEAES 1335
Q ++ R+ ++K E+ + R + EL + L E+ E +
Sbjct: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
Query: 1336 SAAKLE--MAQLKSDL-AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD 1392
S + + ++ +++L A+L + + + L +L+ ER+ L
Sbjct: 693 SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL- 751
Query: 1393 RMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ + + + K+ E + L KLK L+ ++ +++ + + V L +
Sbjct: 752 KNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVA- 810
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQA--QGELLHVQKELSTALGEIKTLQEKLGT 1510
A +EL K +L E + + K A Q + + E + + KL
Sbjct: 811 ARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQE 870
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHH 1570
E A + Q ER ++ + AR+ Q E E+ + +E
Sbjct: 871 EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSME--- 927
Query: 1571 DXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTK 1630
+ + ER+ R +++ K K + +
Sbjct: 928 EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 987
Query: 1631 TRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAE 1674
++ +D+LKSLH V + +ER Q E + A+
Sbjct: 988 KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQ 1031
Score = 47.2 bits (107), Expect = 6e-04
Identities = 108/584 (18%), Positives = 237/584 (40%), Gaps = 47/584 (8%)
Query: 366 QIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSS--LRRE 423
Q+E K+ AA+T EL DE E ++++ +++ + + E L ++
Sbjct: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
Query: 424 LEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGM-QRENRIKELEQEV 482
L ++ L + E + ++ +QE A +K++ ++ D + ++ + ++ +
Sbjct: 498 LSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQK 557
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
+ + + ++ + S+ + K + E +K LT G + A L +DL
Sbjct: 558 SGKEQQLDIMNKQYQQLESRLDEILSRIAK--ETEEIKDLEEQLTEGQIAANEA-LKKDL 614
Query: 543 QDSLEREADLREQLRNAEEETAN-CKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
+ + + ++ + N C+++ Q +T+ V + + E V +N
Sbjct: 615 EGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE--VEQERDQLEIVAMDAEN 672
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEE-TQFHFDLPYLSIFNHMAANNLRKTAARVEED 660
A S+ ++ S+ +T + + + +L AN L++ +V
Sbjct: 673 MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKV--- 729
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ L QL++ A +A +L A K ++ A ++EK EQE
Sbjct: 730 --TRLTQLEQSALQA---ELEKERQALKNALGKAQFSEEK-----------------EQE 767
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSAGSNTTARRSLTTNSNKL 774
+ L K++ L+ D LK+Q+K+ + ++ V + A RR L + ++
Sbjct: 768 NSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEM 827
Query: 775 -AEERVKVLEDEIDEVRKKLIE--KERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ-N 830
VL + +++K+ E ER A++ + + + ++ L ++
Sbjct: 828 NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFR 887
Query: 831 VDLKRQLQV-IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+R L+ + + A+ Q +E + LQ K ++ ++ L+ +A + +
Sbjct: 888 QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERI 947
Query: 890 TTQL-ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
QL E E K+ L K E + +K KK++ AT + T
Sbjct: 948 LAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT 991
Score = 39.5 bits (88), Expect = 0.12
Identities = 104/562 (18%), Positives = 206/562 (36%), Gaps = 47/562 (8%)
Query: 1255 KADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYD-EATSPVEMVEMRXXXXXXX 1311
K+ Y+ + + ES I +A+ V IK++E Q ND + +P++
Sbjct: 390 KSRYKRNMFATESYIIDSAQAVQIKKMEPD-EQLRNDHMNLRGHTPLD-----TQLEDKE 443
Query: 1312 XXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSS 1371
Q L+ ++EK E + A E QL+ + +L+
Sbjct: 444 KKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLSGRL 502
Query: 1372 YWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGK----LKILEQNSGAGA 1427
NK ++ DL+ + +K + K++K+ + +L K + Q SG
Sbjct: 503 QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGK-E 561
Query: 1428 KRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGEL 1487
+++ + ++Y++ +L+ L+ E EE+ E L E + L K+ +G +
Sbjct: 562 QQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEAL---KKDLEGVI 618
Query: 1488 LHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERA 1543
+Q+ L T G+ Q KL E TE++ L+ + E A
Sbjct: 619 SGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELA 678
Query: 1544 RLNARL-DQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXX 1602
L + L +Q E + D+ + + E + K+ R
Sbjct: 679 ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQS 738
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
++ + KA+ ++ K E LH ++ + + + K
Sbjct: 739 ALQAELEKERQALKNA--LGKAQFSEEK----------EQENSELHAKLKHLQDDNNLLK 786
Query: 1663 QMLEAAQKSMAEIKNGDKSARIHRNSISS-TDEEEYRNKVALLEQQVACLEDELCESRLL 1721
Q L+ Q + + +G + +++ DE + K+ E + D L +S
Sbjct: 787 QQLKDFQNHLNHVVDG----LVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLAD 842
Query: 1722 ASKLNTELVS----EKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA---GLATRMELAW 1774
K +E+++ E+ A+VR ++Q + +E+ R A L RM
Sbjct: 843 LQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK 902
Query: 1775 HKERDEQQRLLQETSTLARDLR 1796
+ Q++ E L +L+
Sbjct: 903 RQHEARIQQMENEIHYLQENLK 924
Score = 36.3 bits (80), Expect = 1.1
Identities = 60/326 (18%), Positives = 127/326 (38%), Gaps = 12/326 (3%)
Query: 1219 HRRLSIELTSEKDELQ-ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK---DV 1274
H L E++ +D +Q + K E ++ + A R + + E +++ + K +
Sbjct: 1318 HHNLENEVSRLEDIMQHLKSKKREERW--MRASKRQSEKEMEELHHNIDDLLQEKKSLEC 1375
Query: 1275 HIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAE 1334
+++L +++ K D VE + DE+ + L K +E
Sbjct: 1376 EVEELHRTVQKRQQQK-DFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434
Query: 1335 SSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM 1394
A +A+ +S+L+ + E+ A+EL+ Q L
Sbjct: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL--- 1491
Query: 1395 RIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+ D+ +++ A+ L+ + KI ++ +I K + + K + L E +
Sbjct: 1492 -VKADQQLRSLQADAKDLE-QHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK 1549
Query: 1455 YEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAA 1514
++ E E+ H+ V + + EL ++ ++++ E+ L +LG +
Sbjct: 1550 LQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEE 1609
Query: 1515 WNTEKTEMQNSIASLQERLCGGGWEV 1540
+ + M + A LQE L G EV
Sbjct: 1610 LHLLQGSMVQAKADLQEALRLGETEV 1635
Score = 35.9 bits (79), Expect = 1.5
Identities = 123/777 (15%), Positives = 302/777 (38%), Gaps = 57/777 (7%)
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP-------KTLIKSRSL 823
S + +E+ ++ L ID++ ++ E + E LH + Q++ ++L+ +
Sbjct: 1348 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEI 1407
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK---KLQLLKNA--KSLR 878
+ S + + D+ +++ IE+ ++L+ +++ EAD + E++ + KNA K
Sbjct: 1408 EKSLKHHEDIVDEIECIEK--TLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTD 1465
Query: 879 SDKALDLNTKKTTQLENELKEALAKI----KELEMICQDEK--SEKKVRFTEATKKETDT 932
+ ++L +LE +E + ++L + D K + K++ E K+
Sbjct: 1466 AKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKI 1525
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
+ +K Q ++ + + + + + +L+K+
Sbjct: 1526 VAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKL 1585
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
+ + EM V+ + G +E+ + + + +++ L ++E T + N ++ E
Sbjct: 1586 KSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR-E 1644
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
+ L + + +G+ +V ++ K + + + + + E ++ Q++K +LKN
Sbjct: 1645 VKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
Query: 1112 TSL----QTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN---KLLKEVG 1164
+ + +++N +I Q + + K++
Sbjct: 1702 LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
Query: 1165 DKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI 1224
++ K+ + C +E ++D VLA +
Sbjct: 1762 ERDKREIERMTAESRALQSC--VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM 1819
Query: 1225 ELTS-EKDELQARFIKTE-----SKFITLEAEMRDLKADYENK---ITSLESTIAAKDVH 1275
E ++ EK EL R ++ E ++L ++ ++ + K + SL+ +A H
Sbjct: 1820 EQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDH 1879
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
+ + L TT + D S E ++ Q E + +L+ + E
Sbjct: 1880 LNLAKQDLLHTTKHQ-DVLLS--EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI 1936
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
KL++ Q + +L+ + + +L+ +L ++ KLD++
Sbjct: 1937 EENKLKLVQQEMMFQRLQKERESEESKLETSKVT---LKEQQHQLEKELTDQKSKLDQVL 1993
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+A ++ V+ E + K L Q ++R +L ++ E + L+ +
Sbjct: 1994 SKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELL-ALQKEADSMR 2052
Query: 1453 AEYEELTGKY----ELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
A++ L ++ + E++ K L +++ Q + LL ++E S E+ T++
Sbjct: 2053 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE 2109
>AK074079-1|BAB84905.1| 1793|Homo sapiens FLJ00150 protein protein.
Length = 1793
Score = 75.4 bits (177), Expect = 2e-12
Identities = 177/877 (20%), Positives = 357/877 (40%), Gaps = 97/877 (11%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ + ++E L +D L + + +E E + L R K + E L + ++
Sbjct: 818 RQSEKEMEELHHNIDDLLQEKKSLECEVEE--LHRTVQKRQQQKDFIDGNVESLMTELEI 875
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
+ H+ED+ DE + + + + + SEL EA R + + ++L + + ++
Sbjct: 876 EKSLKHHEDIVDEIECIEKTLLKRRSELR-----EAD-RLLAEAESELSCTKEKTKNAVE 929
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ D K+ L E A+E L R ++T N +L+ + A
Sbjct: 930 KFTDAKRSLLQ------------TESDAEE---LERRAQETAVNLVKADQQLRSLQADAK 974
Query: 447 QLEQEKAEHE---KKLLEIVGGPDG-----MQRENRIKELEQEVARSTEVALRLQ----R 494
LEQ K + E K++ +IV D +++ ++ E Q++ + E+A R + +
Sbjct: 975 DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ 1034
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSL--TRGGSQEDPAQLLRDLQDSLEREADL 552
L E+ L K+ T + ++ + G +++ LL+ ++ +ADL
Sbjct: 1035 VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG--SMVQAKADL 1092
Query: 553 REQLRNAEEE-TANCKQVNP-PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+E LR E E T C + + L++ + I E +T I+ ++
Sbjct: 1093 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI------- 1145
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
KE+ + + + +T+ L L + NH + RV E ++ Q+
Sbjct: 1146 -EKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKT---QVAV 1201
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ K L K IE +K+ E D E +E E+ L+ VE
Sbjct: 1202 LEEKLELENLQQISQQQKGEIEW-----QKQLLERDKRE----IERMTAESRALQSCVEC 1252
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
L ++KE L+++ K++ + A + ++ +N KL E V+ L+ E+D++
Sbjct: 1253 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKME-QSNLEKL-ELNVRKLQQELDQL- 1309
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
RD LH ++S Q++ + K ++++ ++ +++ L + +Q+
Sbjct: 1310 ------NRDKLSLHNDISAMQQQLQE--KREAVNSLQEELANVQDHLNLAKQDLLHTTKH 1361
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
L ++ +LQ K + N + K + ++ L+NE++E K+ + EM+
Sbjct: 1362 QDVLLSEQTRLQ---KDISEWAN-RFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMM 1417
Query: 911 CQDEKSEKKVRFTEATKKETD--TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
Q + E++ +E +K ET TLK +Q +
Sbjct: 1418 FQRLQKERE---SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 1474
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAG--------LSGKEMTAK 1020
Q+ + + T TK QL + + L + GE+ + K A L + +T +
Sbjct: 1475 QEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER 1534
Query: 1021 TKLEKEIDEI-------RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K EK++ + RS+L KN E E + +Q E+A ++ V +
Sbjct: 1535 KKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKEL 1594
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
++ E + L Q ++++ R+ +I+ LK+
Sbjct: 1595 NQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS 1630
Score = 54.0 bits (124), Expect = 5e-06
Identities = 153/869 (17%), Positives = 355/869 (40%), Gaps = 59/869 (6%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVL 320
S ++E + + E+ +++ + ++ +D LL+ ++ + + + ++
Sbjct: 901 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 960
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST-EAQTRQIEQLRAKLLAAET 379
K Q++ L +DL K + ++EI + + S + +++ E+L +L +
Sbjct: 961 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 1020
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
E + + NED L+ L +Q E + + ++ E + + R L K +
Sbjct: 1021 DIE-MAERNED--HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLD-RQLGHKKE 1076
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEA 499
+ + Q KA+ ++ L +G + ++ N I+E++ + + L +++E
Sbjct: 1077 ELHLLQGSMVQAKADLQEALR--LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER 1134
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
++ T + K + E ++V +++ ++ L+++ D L+ E + L+
Sbjct: 1135 KTQLTLIKQEIEK--EEENLQVVLRQMSKHKTE------LKNILDMLQLENHELQGLKLQ 1186
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
++ + + L++++ +N+ I + + Q +++ + ++S
Sbjct: 1187 HDQRVSELEKTQVAVLEEKLELENLQ--QISQQQKGEIEWQKQLLERDKREIERMTAESR 1244
Query: 620 PLS-----IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
L + K E+ Q D I+ A R AA EE+++ L+K+
Sbjct: 1245 ALQSCVECLSKEKEDLQEKCD-----IWEKKLAQTKRVLAA-AEENSKMEQSNLEKLELN 1298
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
R + N+ + ND + + E + L E+ A V + L
Sbjct: 1299 VRKLQ-QELDQLNRDKLSLHNDISAMQQQLQEKREA--VNSLQEELANVQ----DHLNLA 1351
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARR-SLTTNSNKLAEERVKVLEDEIDEVRKKL 793
K+ L K +S T+ + A R + +++++VL++EI+E + KL
Sbjct: 1352 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1411
Query: 794 IEKERDCERLHAELSLAQKKPKT--LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+++E +RL E + K +T + +++ D K +L + + +
Sbjct: 1412 VQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV 1471
Query: 852 QSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK-KTTQLENELKEALAKIKELEMI 910
++L+ + ++ K L K S R + ++ + + Q E + A + + +
Sbjct: 1472 RTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFL 1531
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ +K+EK+V A+ KE LK ++ AT++ + D +
Sbjct: 1532 TERKKAEKQV----ASLKE--ALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHE 1585
Query: 971 SFKPRIPKKPTDLTTK-LQLKKMV---EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
+ R+ K+ + + +LKK + +DLE E+ M+ K+ +T L K
Sbjct: 1586 RAR-RLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKD-EIRTSL-KN 1642
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+++ +L + L+ E+ LK+ N ++ F K + + +
Sbjct: 1643 LNQFLPELPADLEAILERNENLEGELESLKE-NLPFTMNEGPFEEKLNFSQVHIMDEHWR 1701
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+ L E++++RE ++L A L++ S Q
Sbjct: 1702 GEALREKLRHRE---DRLKAQLRHCMSKQ 1727
Score = 52.4 bits (120), Expect = 2e-05
Identities = 120/592 (20%), Positives = 222/592 (37%), Gaps = 75/592 (12%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQ 1285
L+ EK++LQ + E K L R L A EN +S + ++++++L+ L Q
Sbjct: 1253 LSKEKEDLQEKCDIWEKK---LAQTKRVLAAAEENSKME-QSNLEKLELNVRKLQQELDQ 1308
Query: 1286 TTNDKY----DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
DK D + ++ E R QD LN AK L T E
Sbjct: 1309 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1368
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE--------------LDTDLQSE 1387
+L+ D+++ N +N+ +E L + +SE
Sbjct: 1369 QTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE 1428
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
KL+ ++ + + EL K KL + A +R+ L QE E + LE +
Sbjct: 1429 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL-QEEERWCESLEKT 1487
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
L+ K + E E+ +V K+ GELL +QKE + + L+ +
Sbjct: 1488 LSQTKRQLSE--------REQQLVEKS----------GELLALQKEADSMRADFSLLRNQ 1529
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+ TE+ + + +ASL+E L +++R++L L ++++E +E
Sbjct: 1530 -------FLTERKKAEKQVASLKEAL-----KIQRSQLEKNLLEQKQENSCIQKEMATIE 1577
Query: 1568 ----HHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
+H+ +Y + K I + + K
Sbjct: 1578 LVAQDNHERARRLMKELNQMQYEYTELKK--------QMANQKDLERRQMEISDAMRTLK 1629
Query: 1624 AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN-GDKSA 1682
+E+ D + + L L + +N + LE+ ++++ N G
Sbjct: 1630 SEVKD---EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEE 1686
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDEL-CESRLLASKLNTELVSEKSSAEVRLA 1741
+++ + + D E +R + L +++ ED L + R SK L+ K E L
Sbjct: 1687 KLNFSQVHIMD-EHWRGEA--LREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLH 1743
Query: 1742 EMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
++ +++ E L++S A A + +L D Q QE + AR
Sbjct: 1744 SLRRQVDALGE--LVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 1793
Score = 50.8 bits (116), Expect = 5e-05
Identities = 103/586 (17%), Positives = 237/586 (40%), Gaps = 55/586 (9%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAAKDVHIKQLED 1281
EL E +K + + +L+A+ +DL K E + + +AAKD + L
Sbjct: 947 ELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSK 1006
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
+ T ++ + +EM E ++E ++ ++ L+++E A + E
Sbjct: 1007 KKEKLT-EELQKLQKDIEMAE---------------RNEDHHLQV-LKESEVLLQAKRAE 1049
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIA---- 1397
+ +LKS + + + + DLQ E +L +
Sbjct: 1050 LEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ-EALRLGETEVTEKCN 1108
Query: 1398 HDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEE 1457
H ++VK+ EL+ KG+L + ++T +KQE E+ + L+ L E
Sbjct: 1109 HIREVKSLLEELSFQKGELNV---QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1165
Query: 1458 LTGKYELLEEEHVVTKARLTVEKEQAQG-ELLHVQKELSTALGEIKTLQEKLGTESAAWN 1516
L ++L+ +E + QG +L H Q+ ++ L+EKL E+
Sbjct: 1166 LKNILDMLQ-----------LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQI 1214
Query: 1517 TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXX 1576
++ + + I ++ L E+ER +R Q E + ++ L+ D
Sbjct: 1215 SQ--QQKGEIEWQKQLLERDKREIERMTAESRALQSCVE--CLSKEKEDLQEKCDIWEKK 1270
Query: 1577 XXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQ 1636
E SK+++ + + + + +I+ + + + +
Sbjct: 1271 LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK 1330
Query: 1637 ---MNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTD 1693
+N++++EL ++ + ++ +++ + + + ++ D S +R +
Sbjct: 1331 REAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQK-DISEWANRFEDCQKE 1389
Query: 1694 EEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
EE + ++ +L+ ++ + +L + ++ +L E SE+S E ++ + ++ E+E
Sbjct: 1390 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1449
Query: 1754 RLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
L+ ++++ + +++ A +E+ R LQE L +TL
Sbjct: 1450 --LTDQKSKLDQVLSKVLAA-----EERVRTLQEEERWCESLEKTL 1488
Score = 48.4 bits (110), Expect = 3e-04
Identities = 82/338 (24%), Positives = 148/338 (43%), Gaps = 55/338 (16%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANI----DTANKYTTGR--SSEVLK---- 321
Q G +Q++DI+ K+ +++E +IL R D + T G+ ++E LK
Sbjct: 30 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLE 89
Query: 322 -----LQQKVNELT-----THNE--DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ 369
LQ+ + + NE LRDEK+ L Q++ E+E E R E E
Sbjct: 90 GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQE---RDQLEIVAMDAEN 146
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
+R +L E+ +E + N +++ DL ++ A E + L+ ELE+ +
Sbjct: 147 MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDA-EANQLKEELEKVTR 205
Query: 430 NCRV----LSFKLKKTERKA-----------DQLEQEKAEHEKKLLEIVGGPDGMQR--- 471
++ L +L+K ER+A ++ EQE +E KL + + +++
Sbjct: 206 LTQLEQSALQAELEK-ERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLK 264
Query: 472 --ENRIKELEQEVARSTEVALR---LQRELAEANSKFTGSNPS-LMKVPQPETVKVSRSS 525
+N + + + R EVA R L+R+L + +PS ++ + K
Sbjct: 265 DFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI 324
Query: 526 LTRGGSQEDPAQLL-RDLQDSLEREADLREQLRNAEEE 562
L R + D AQ+ R LQ+ + + +E+L +EE
Sbjct: 325 LARSKWERDEAQVRERKLQEEMALQ---QEKLATGQEE 359
Score = 47.6 bits (108), Expect = 5e-04
Identities = 82/464 (17%), Positives = 164/464 (35%), Gaps = 19/464 (4%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRD--------LKADYENKITSLESTIAAKDVHI 1276
+L S DE+ +R K + LE ++ + LK D E I+ L+ +
Sbjct: 47 QLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQA 106
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL-EKTEAES 1335
Q ++ R+ ++K E+ + R + EL + L E+ E +
Sbjct: 107 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 166
Query: 1336 SAAKLE--MAQLKSDL-AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD 1392
S + + ++ +++L A+L + + + L +L+ ER+ L
Sbjct: 167 SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL- 225
Query: 1393 RMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ + + + K+ E + L KLK L+ ++ +++ + + V L +
Sbjct: 226 KNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVA- 284
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQA--QGELLHVQKELSTALGEIKTLQEKLGT 1510
A +EL K +L E + + K A Q + + E + + KL
Sbjct: 285 ARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQE 344
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHH 1570
E A + Q ER ++ + AR+ Q E E+ + +E
Sbjct: 345 EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSME--- 401
Query: 1571 DXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTK 1630
+ + ER+ R +++ K K + +
Sbjct: 402 EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 461
Query: 1631 TRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAE 1674
++ +D+LKSLH V + +ER Q E + A+
Sbjct: 462 KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQ 505
Score = 47.2 bits (107), Expect = 6e-04
Identities = 79/420 (18%), Positives = 178/420 (42%), Gaps = 40/420 (9%)
Query: 703 DEADP--AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSN 760
D DP + MK EQ+ ++ ++ ++LE + + ++ + T +I + +
Sbjct: 18 DSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQ 77
Query: 761 TTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKS 820
A +L K E + L++ + ++ + + + +C +L E +TL+
Sbjct: 78 IAANEAL----KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDE-------KETLL-- 124
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK---NAKSL 877
+ L +Q+ + QL+++ +A +R + LE+ ++ N LQ + +A
Sbjct: 125 QRLTEVEQE----RDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 180
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ L+L + QL+ EL E + ++ +LE + EK+ + + + + K+
Sbjct: 181 ELEARLNLRDAEANQLKEEL-EKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 239
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE 997
+ LK ++ + +P ++ ++ ++ L+
Sbjct: 240 QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLV--RPEEVAARVD--ELRRKLK 295
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEI--RSKLSKNDSEFTNEKNRLQTEIAKL 1055
GEM + + + GK + L+K+ EI RSK +++++ K LQ E+A
Sbjct: 296 LGTGEMN-IHSPSDVLGKSL---ADLQKQFSEILARSKWERDEAQVRERK--LQEEMALQ 349
Query: 1056 KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
++ A G ++ +ALE + Q + ++M+N +I+ L +LK+ +Q
Sbjct: 350 QEKLA--TGQEEFRQACERALEARMNFDKRQHEARIQQMEN---EIHYLQENLKSMEEIQ 404
Score = 39.1 bits (87), Expect = 0.16
Identities = 58/269 (21%), Positives = 122/269 (45%), Gaps = 21/269 (7%)
Query: 852 QSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI-KELEMI 910
+ L+ + L +++ K +K KS + ++ LD+ K+ QLE+ L E L++I KE E I
Sbjct: 8 KDLQIAIDSLDSKDPKHSHMKAQKSGK-EQQLDIMNKQYQQLESRLDEILSRIAKETEEI 66
Query: 911 --CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+++ +E ++ EA KK+ + + S Q + L+D+
Sbjct: 67 KDLEEQLTEGQIAANEALKKDLEGVIS------GLQEYLGTIKGQATQAQNECRKLRDE- 119
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKM-VEDLECEIGEM-YVVMKNAGLSGKEMTAKTKLEKE 1026
+++ R+ + + +L++ M E++ E+ E+ + + ++ + L
Sbjct: 120 KETLLQRLTEVEQE-RDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAY 178
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQ--TEIAKLKD--VNAKLEGDKDVFANKY-KALENENS 1081
E+ ++L+ D+E K L+ T + +L+ + A+LE ++ N KA +E
Sbjct: 179 EAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEK 238
Query: 1082 NLSNQCKTLTEEMKNREAQINKLSADLKN 1110
N L ++K+ + N L LK+
Sbjct: 239 EQEN--SELHAKLKHLQDDNNLLKQQLKD 265
Score = 39.1 bits (87), Expect = 0.16
Identities = 49/230 (21%), Positives = 98/230 (42%), Gaps = 12/230 (5%)
Query: 715 ELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSAGSNTTARRSLT 768
E EQE + L K++ L+ D LK+Q+K+ + ++ V + A RR L
Sbjct: 236 EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 295
Query: 769 TNSNKL-AEERVKVLEDEIDEVRKKLIE--KERDCERLHAELSLAQKKPKTLIKSRSLDA 825
+ ++ VL + +++K+ E ER A++ + + + ++ L
Sbjct: 296 LGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLAT 355
Query: 826 SDQQ-NVDLKRQLQV-IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKAL 883
++ +R L+ + + A+ Q +E + LQ K ++ ++ L+ +A
Sbjct: 356 GQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEAD 415
Query: 884 DLNTKKTTQL-ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+ + QL E E K+ L K E + +K KK++ AT + T
Sbjct: 416 EEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT 465
Score = 36.3 bits (80), Expect = 1.1
Identities = 60/326 (18%), Positives = 127/326 (38%), Gaps = 12/326 (3%)
Query: 1219 HRRLSIELTSEKDELQ-ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK---DV 1274
H L E++ +D +Q + K E ++ + A R + + E +++ + K +
Sbjct: 786 HHNLENEVSRLEDIMQHLKSKKREERW--MRASKRQSEKEMEELHHNIDDLLQEKKSLEC 843
Query: 1275 HIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAE 1334
+++L +++ K D VE + DE+ + L K +E
Sbjct: 844 EVEELHRTVQKRQQQK-DFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 902
Query: 1335 SSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM 1394
A +A+ +S+L+ + E+ A+EL+ Q L
Sbjct: 903 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL--- 959
Query: 1395 RIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+ D+ +++ A+ L+ + KI ++ +I K + + K + L E +
Sbjct: 960 -VKADQQLRSLQADAKDLE-QHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK 1017
Query: 1455 YEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAA 1514
++ E E+ H+ V + + EL ++ ++++ E+ L +LG +
Sbjct: 1018 LQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEE 1077
Query: 1515 WNTEKTEMQNSIASLQERLCGGGWEV 1540
+ + M + A LQE L G EV
Sbjct: 1078 LHLLQGSMVQAKADLQEALRLGETEV 1103
Score = 35.9 bits (79), Expect = 1.5
Identities = 123/777 (15%), Positives = 302/777 (38%), Gaps = 57/777 (7%)
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP-------KTLIKSRSL 823
S + +E+ ++ L ID++ ++ E + E LH + Q++ ++L+ +
Sbjct: 816 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEI 875
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK---KLQLLKNA--KSLR 878
+ S + + D+ +++ IE+ ++L+ +++ EAD + E++ + KNA K
Sbjct: 876 EKSLKHHEDIVDEIECIEK--TLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTD 933
Query: 879 SDKALDLNTKKTTQLENELKEALAKI----KELEMICQDEK--SEKKVRFTEATKKETDT 932
+ ++L +LE +E + ++L + D K + K++ E K+
Sbjct: 934 AKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKI 993
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
+ +K Q ++ + + + + + +L+K+
Sbjct: 994 VAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKL 1053
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
+ + EM V+ + G +E+ + + + +++ L ++E T + N ++ E
Sbjct: 1054 KSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR-E 1112
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
+ L + + +G+ +V ++ K + + + + + E ++ Q++K +LKN
Sbjct: 1113 VKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1169
Query: 1112 TSL----QTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN---KLLKEVG 1164
+ + +++N +I Q + + K++
Sbjct: 1170 LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1229
Query: 1165 DKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI 1224
++ K+ + C +E ++D VLA +
Sbjct: 1230 ERDKREIERMTAESRALQSC--VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM 1287
Query: 1225 ELTS-EKDELQARFIKTE-----SKFITLEAEMRDLKADYENK---ITSLESTIAAKDVH 1275
E ++ EK EL R ++ E ++L ++ ++ + K + SL+ +A H
Sbjct: 1288 EQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDH 1347
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
+ + L TT + D S E ++ Q E + +L+ + E
Sbjct: 1348 LNLAKQDLLHTTKHQ-DVLLS--EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI 1404
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
KL++ Q + +L+ + + +L+ +L ++ KLD++
Sbjct: 1405 EENKLKLVQQEMMFQRLQKERESEESKLETSKVT---LKEQQHQLEKELTDQKSKLDQVL 1461
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+A ++ V+ E + K L Q ++R +L ++ E + L+ +
Sbjct: 1462 SKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELL-ALQKEADSMR 1520
Query: 1453 AEYEELTGKY----ELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
A++ L ++ + E++ K L +++ Q + LL ++E S E+ T++
Sbjct: 1521 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE 1577
>AF513978-1|AAP43846.1| 2325|Homo sapiens CENTRIOLIN protein.
Length = 2325
Score = 75.4 bits (177), Expect = 2e-12
Identities = 177/877 (20%), Positives = 357/877 (40%), Gaps = 97/877 (11%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ + ++E L +D L + + +E E + L R K + E L + ++
Sbjct: 1350 RQSEKEMEELHHNIDDLLQEKKSLECEVEE--LHRTVQKRQQQKDFIDGNVESLMTELEI 1407
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
+ H+ED+ DE + + + + + SEL EA R + + ++L + + ++
Sbjct: 1408 EKSLKHHEDIVDEIECIEKTLLKRRSELR-----EAD-RLLAEAESELSCTKEKTKNAVE 1461
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ D K+ L E A+E L R ++T N +L+ + A
Sbjct: 1462 KFTDAKRSLLQ------------TESDAEE---LERRAQETAVNLVKADQQLRSLQADAK 1506
Query: 447 QLEQEKAEHE---KKLLEIVGGPDG-----MQRENRIKELEQEVARSTEVALRLQ----R 494
LEQ K + E K++ +IV D +++ ++ E Q++ + E+A R + +
Sbjct: 1507 DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ 1566
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSL--TRGGSQEDPAQLLRDLQDSLEREADL 552
L E+ L K+ T + ++ + G +++ LL+ ++ +ADL
Sbjct: 1567 VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG--SMVQAKADL 1624
Query: 553 REQLRNAEEE-TANCKQVNP-PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+E LR E E T C + + L++ + I E +T I+ ++
Sbjct: 1625 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI------- 1677
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
KE+ + + + +T+ L L + NH + RV E ++ Q+
Sbjct: 1678 -EKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKT---QVAV 1733
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ K L K IE +K+ E D E +E E+ L+ VE
Sbjct: 1734 LEEKLELENLQQISQQQKGEIEW-----QKQLLERDKRE----IERMTAESRALQSCVEC 1784
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
L ++KE L+++ K++ + A + ++ +N KL E V+ L+ E+D++
Sbjct: 1785 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKME-QSNLEKL-ELNVRKLQQELDQL- 1841
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
RD LH ++S Q++ + K ++++ ++ +++ L + +Q+
Sbjct: 1842 ------NRDKLSLHNDISAMQQQLQE--KREAVNSLQEELANVQDHLNLAKQDLLHTTKH 1893
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
L ++ +LQ K + N + K + ++ L+NE++E K+ + EM+
Sbjct: 1894 QDVLLSEQTRLQ---KDISEWAN-RFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMM 1949
Query: 911 CQDEKSEKKVRFTEATKKETD--TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
Q + E++ +E +K ET TLK +Q +
Sbjct: 1950 FQRLQKERE---SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAG--------LSGKEMTAK 1020
Q+ + + T TK QL + + L + GE+ + K A L + +T +
Sbjct: 2007 QEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER 2066
Query: 1021 TKLEKEIDEI-------RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K EK++ + RS+L KN E E + +Q E+A ++ V +
Sbjct: 2067 KKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKEL 2126
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
++ E + L Q ++++ R+ +I+ LK+
Sbjct: 2127 NQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS 2162
Score = 54.0 bits (124), Expect = 5e-06
Identities = 153/869 (17%), Positives = 355/869 (40%), Gaps = 59/869 (6%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVL 320
S ++E + + E+ +++ + ++ +D LL+ ++ + + + ++
Sbjct: 1433 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 1492
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST-EAQTRQIEQLRAKLLAAET 379
K Q++ L +DL K + ++EI + + S + +++ E+L +L +
Sbjct: 1493 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 1552
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
E + + NED L+ L +Q E + + ++ E + + R L K +
Sbjct: 1553 DIE-MAERNED--HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLD-RQLGHKKE 1608
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEA 499
+ + Q KA+ ++ L +G + ++ N I+E++ + + L +++E
Sbjct: 1609 ELHLLQGSMVQAKADLQEALR--LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER 1666
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
++ T + K + E ++V +++ ++ L+++ D L+ E + L+
Sbjct: 1667 KTQLTLIKQEIEK--EEENLQVVLRQMSKHKTE------LKNILDMLQLENHELQGLKLQ 1718
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
++ + + L++++ +N+ I + + Q +++ + ++S
Sbjct: 1719 HDQRVSELEKTQVAVLEEKLELENLQ--QISQQQKGEIEWQKQLLERDKREIERMTAESR 1776
Query: 620 PLS-----IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
L + K E+ Q D I+ A R AA EE+++ L+K+
Sbjct: 1777 ALQSCVECLSKEKEDLQEKCD-----IWEKKLAQTKRVLAA-AEENSKMEQSNLEKLELN 1830
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
R + N+ + ND + + E + L E+ A V + L
Sbjct: 1831 VRKLQ-QELDQLNRDKLSLHNDISAMQQQLQEKREA--VNSLQEELANVQ----DHLNLA 1883
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARR-SLTTNSNKLAEERVKVLEDEIDEVRKKL 793
K+ L K +S T+ + A R + +++++VL++EI+E + KL
Sbjct: 1884 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 1943
Query: 794 IEKERDCERLHAELSLAQKKPKT--LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+++E +RL E + K +T + +++ D K +L + + +
Sbjct: 1944 VQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV 2003
Query: 852 QSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK-KTTQLENELKEALAKIKELEMI 910
++L+ + ++ K L K S R + ++ + + Q E + A + + +
Sbjct: 2004 RTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFL 2063
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ +K+EK+V A+ KE LK ++ AT++ + D +
Sbjct: 2064 TERKKAEKQV----ASLKE--ALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHE 2117
Query: 971 SFKPRIPKKPTDLTTK-LQLKKMV---EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
+ R+ K+ + + +LKK + +DLE E+ M+ K+ +T L K
Sbjct: 2118 RAR-RLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKD-EIRTSL-KN 2174
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+++ +L + L+ E+ LK+ N ++ F K + + +
Sbjct: 2175 LNQFLPELPADLEAILERNENLEGELESLKE-NLPFTMNEGPFEEKLNFSQVHIMDEHWR 2233
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+ L E++++RE ++L A L++ S Q
Sbjct: 2234 GEALREKLRHRE---DRLKAQLRHCMSKQ 2259
Score = 52.4 bits (120), Expect = 2e-05
Identities = 120/592 (20%), Positives = 222/592 (37%), Gaps = 75/592 (12%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQ 1285
L+ EK++LQ + E K L R L A EN +S + ++++++L+ L Q
Sbjct: 1785 LSKEKEDLQEKCDIWEKK---LAQTKRVLAAAEENSKME-QSNLEKLELNVRKLQQELDQ 1840
Query: 1286 TTNDKY----DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
DK D + ++ E R QD LN AK L T E
Sbjct: 1841 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 1900
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE--------------LDTDLQSE 1387
+L+ D+++ N +N+ +E L + +SE
Sbjct: 1901 QTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE 1960
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
KL+ ++ + + EL K KL + A +R+ L QE E + LE +
Sbjct: 1961 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL-QEEERWCESLEKT 2019
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
L+ K + E E+ +V K+ GELL +QKE + + L+ +
Sbjct: 2020 LSQTKRQLSE--------REQQLVEKS----------GELLALQKEADSMRADFSLLRNQ 2061
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+ TE+ + + +ASL+E L +++R++L L ++++E +E
Sbjct: 2062 -------FLTERKKAEKQVASLKEAL-----KIQRSQLEKNLLEQKQENSCIQKEMATIE 2109
Query: 1568 ----HHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
+H+ +Y + K I + + K
Sbjct: 2110 LVAQDNHERARRLMKELNQMQYEYTELKK--------QMANQKDLERRQMEISDAMRTLK 2161
Query: 1624 AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN-GDKSA 1682
+E+ D + + L L + +N + LE+ ++++ N G
Sbjct: 2162 SEVKD---EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEE 2218
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDEL-CESRLLASKLNTELVSEKSSAEVRLA 1741
+++ + + D E +R + L +++ ED L + R SK L+ K E L
Sbjct: 2219 KLNFSQVHIMD-EHWRGEA--LREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLH 2275
Query: 1742 EMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
++ +++ E L++S A A + +L D Q QE + AR
Sbjct: 2276 SLRRQVDALGE--LVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 2325
Score = 50.8 bits (116), Expect = 5e-05
Identities = 103/586 (17%), Positives = 237/586 (40%), Gaps = 55/586 (9%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDL---KADYENKITSLESTIAAKDVHIKQLED 1281
EL E +K + + +L+A+ +DL K E + + +AAKD + L
Sbjct: 1479 ELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSK 1538
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
+ T ++ + +EM E ++E ++ ++ L+++E A + E
Sbjct: 1539 KKEKLT-EELQKLQKDIEMAE---------------RNEDHHLQV-LKESEVLLQAKRAE 1581
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIA---- 1397
+ +LKS + + + + DLQ E +L +
Sbjct: 1582 LEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQ-EALRLGETEVTEKCN 1640
Query: 1398 HDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEE 1457
H ++VK+ EL+ KG+L + ++T +KQE E+ + L+ L E
Sbjct: 1641 HIREVKSLLEELSFQKGELNV---QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1697
Query: 1458 LTGKYELLEEEHVVTKARLTVEKEQAQG-ELLHVQKELSTALGEIKTLQEKLGTESAAWN 1516
L ++L+ +E + QG +L H Q+ ++ L+EKL E+
Sbjct: 1698 LKNILDMLQ-----------LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQI 1746
Query: 1517 TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXX 1576
++ + + I ++ L E+ER +R Q E + ++ L+ D
Sbjct: 1747 SQ--QQKGEIEWQKQLLERDKREIERMTAESRALQSCVE--CLSKEKEDLQEKCDIWEKK 1802
Query: 1577 XXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQ 1636
E SK+++ + + + + +I+ + + + +
Sbjct: 1803 LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK 1862
Query: 1637 ---MNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTD 1693
+N++++EL ++ + ++ +++ + + + ++ D S +R +
Sbjct: 1863 REAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQK-DISEWANRFEDCQKE 1921
Query: 1694 EEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
EE + ++ +L+ ++ + +L + ++ +L E SE+S E ++ + ++ E+E
Sbjct: 1922 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 1981
Query: 1754 RLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
L+ ++++ + +++ A +E+ R LQE L +TL
Sbjct: 1982 --LTDQKSKLDQVLSKVLAA-----EERVRTLQEEERWCESLEKTL 2020
Score = 48.4 bits (110), Expect = 3e-04
Identities = 82/338 (24%), Positives = 148/338 (43%), Gaps = 55/338 (16%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANI----DTANKYTTGR--SSEVLK---- 321
Q G +Q++DI+ K+ +++E +IL R D + T G+ ++E LK
Sbjct: 556 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLE 615
Query: 322 -----LQQKVNELT-----THNE--DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ 369
LQ+ + + NE LRDEK+ L Q++ E+E E R E E
Sbjct: 616 GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQE---RDQLEIVAMDAEN 672
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
+R +L E+ +E + N +++ DL ++ A E + L+ ELE+ +
Sbjct: 673 MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDA-EANQLKEELEKVTR 731
Query: 430 NCRV----LSFKLKKTERKA-----------DQLEQEKAEHEKKLLEIVGGPDGMQR--- 471
++ L +L+K ER+A ++ EQE +E KL + + +++
Sbjct: 732 LTQLEQSALQAELEK-ERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLK 790
Query: 472 --ENRIKELEQEVARSTEVALR---LQRELAEANSKFTGSNPS-LMKVPQPETVKVSRSS 525
+N + + + R EVA R L+R+L + +PS ++ + K
Sbjct: 791 DFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEI 850
Query: 526 LTRGGSQEDPAQLL-RDLQDSLEREADLREQLRNAEEE 562
L R + D AQ+ R LQ+ + + +E+L +EE
Sbjct: 851 LARSKWERDEAQVRERKLQEEMALQ---QEKLATGQEE 885
Score = 47.6 bits (108), Expect = 5e-04
Identities = 82/464 (17%), Positives = 164/464 (35%), Gaps = 19/464 (4%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRD--------LKADYENKITSLESTIAAKDVHI 1276
+L S DE+ +R K + LE ++ + LK D E I+ L+ +
Sbjct: 573 QLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQA 632
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKL-EKTEAES 1335
Q ++ R+ ++K E+ + R + EL + L E+ E +
Sbjct: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA 692
Query: 1336 SAAKLE--MAQLKSDL-AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD 1392
S + + ++ +++L A+L + + + L +L+ ER+ L
Sbjct: 693 SLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL- 751
Query: 1393 RMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ + + + K+ E + L KLK L+ ++ +++ + + V L +
Sbjct: 752 KNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVA- 810
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQA--QGELLHVQKELSTALGEIKTLQEKLGT 1510
A +EL K +L E + + K A Q + + E + + KL
Sbjct: 811 ARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQE 870
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHH 1570
E A + Q ER ++ + AR+ Q E E+ + +E
Sbjct: 871 EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSME--- 927
Query: 1571 DXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTK 1630
+ + ER+ R +++ K K + +
Sbjct: 928 EIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSD 987
Query: 1631 TRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAE 1674
++ +D+LKSLH V + +ER Q E + A+
Sbjct: 988 KLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQ 1031
Score = 47.2 bits (107), Expect = 6e-04
Identities = 108/584 (18%), Positives = 237/584 (40%), Gaps = 47/584 (8%)
Query: 366 QIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSS--LRRE 423
Q+E K+ AA+T EL DE E ++++ +++ + + E L ++
Sbjct: 438 QLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQ 497
Query: 424 LEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGM-QRENRIKELEQEV 482
L ++ L + E + ++ +QE A +K++ ++ D + ++ + ++ +
Sbjct: 498 LSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQK 557
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
+ + + ++ + S+ + K + E +K LT G + A L +DL
Sbjct: 558 SGKEQQLDIMNKQYQQLESRLDEILSRIAK--ETEEIKDLEEQLTEGQIAANEA-LKKDL 614
Query: 543 QDSLEREADLREQLRNAEEETAN-CKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
+ + + ++ + N C+++ Q +T+ V + + E V +N
Sbjct: 615 EGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTE--VEQERDQLEIVAMDAEN 672
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEE-TQFHFDLPYLSIFNHMAANNLRKTAARVEED 660
A S+ ++ S+ +T + + + +L AN L++ +V
Sbjct: 673 MRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKV--- 729
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ L QL++ A +A +L A K ++ A ++EK EQE
Sbjct: 730 --TRLTQLEQSALQA---ELEKERQALKNALGKAQFSEEK-----------------EQE 767
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSAGSNTTARRSLTTNSNKL 774
+ L K++ L+ D LK+Q+K+ + ++ V + A RR L + ++
Sbjct: 768 NSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEM 827
Query: 775 -AEERVKVLEDEIDEVRKKLIE--KERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ-N 830
VL + +++K+ E ER A++ + + + ++ L ++
Sbjct: 828 NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFR 887
Query: 831 VDLKRQLQV-IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+R L+ + + A+ Q +E + LQ K ++ ++ L+ +A + +
Sbjct: 888 QACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERI 947
Query: 890 TTQL-ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
QL E E K+ L K E + +K KK++ AT + T
Sbjct: 948 LAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLAT 991
Score = 39.5 bits (88), Expect = 0.12
Identities = 104/562 (18%), Positives = 206/562 (36%), Gaps = 47/562 (8%)
Query: 1255 KADYENKITSLESTI--AAKDVHIKQLEDALRQTTNDKYD-EATSPVEMVEMRXXXXXXX 1311
K+ Y+ + + ES I +A+ V IK++E Q ND + +P++
Sbjct: 390 KSRYKRNMFATESYIIDSAQAVQIKKMEPD-EQLRNDHMNLRGHTPLD-----TQLEDKE 443
Query: 1312 XXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSS 1371
Q L+ ++EK E + A E QL+ + +L+
Sbjct: 444 KKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLSGRL 502
Query: 1372 YWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGK----LKILEQNSGAGA 1427
NK ++ DL+ + +K + K++K+ + +L K + Q SG
Sbjct: 503 QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGK-E 561
Query: 1428 KRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGEL 1487
+++ + ++Y++ +L+ L+ E EE+ E L E + L K+ +G +
Sbjct: 562 QQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEAL---KKDLEGVI 618
Query: 1488 LHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQNSIASLQ-ERLCGGGWEVERA 1543
+Q+ L T G+ Q KL E TE++ L+ + E A
Sbjct: 619 SGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELA 678
Query: 1544 RLNARL-DQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXX 1602
L + L +Q E + D+ + + E + K+ R
Sbjct: 679 ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQS 738
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
++ + KA+ ++ K E LH ++ + + + K
Sbjct: 739 ALQAELEKERQALKNA--LGKAQFSEEK----------EQENSELHAKLKHLQDDNNLLK 786
Query: 1663 QMLEAAQKSMAEIKNGDKSARIHRNSISS-TDEEEYRNKVALLEQQVACLEDELCESRLL 1721
Q L+ Q + + +G + +++ DE + K+ E + D L +S
Sbjct: 787 QQLKDFQNHLNHVVDG----LVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLAD 842
Query: 1722 ASKLNTELVS----EKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA---GLATRMELAW 1774
K +E+++ E+ A+VR ++Q + +E+ R A L RM
Sbjct: 843 LQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK 902
Query: 1775 HKERDEQQRLLQETSTLARDLR 1796
+ Q++ E L +L+
Sbjct: 903 RQHEARIQQMENEIHYLQENLK 924
Score = 36.3 bits (80), Expect = 1.1
Identities = 60/326 (18%), Positives = 127/326 (38%), Gaps = 12/326 (3%)
Query: 1219 HRRLSIELTSEKDELQ-ARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK---DV 1274
H L E++ +D +Q + K E ++ + A R + + E +++ + K +
Sbjct: 1318 HHNLENEVSRLEDIMQHLKSKKREERW--MRASKRQSEKEMEELHHNIDDLLQEKKSLEC 1375
Query: 1275 HIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAE 1334
+++L +++ K D VE + DE+ + L K +E
Sbjct: 1376 EVEELHRTVQKRQQQK-DFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434
Query: 1335 SSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM 1394
A +A+ +S+L+ + E+ A+EL+ Q L
Sbjct: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL--- 1491
Query: 1395 RIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
+ D+ +++ A+ L+ + KI ++ +I K + + K + L E +
Sbjct: 1492 -VKADQQLRSLQADAKDLE-QHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK 1549
Query: 1455 YEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAA 1514
++ E E+ H+ V + + EL ++ ++++ E+ L +LG +
Sbjct: 1550 LQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEE 1609
Query: 1515 WNTEKTEMQNSIASLQERLCGGGWEV 1540
+ + M + A LQE L G EV
Sbjct: 1610 LHLLQGSMVQAKADLQEALRLGETEV 1635
Score = 35.9 bits (79), Expect = 1.5
Identities = 123/777 (15%), Positives = 302/777 (38%), Gaps = 57/777 (7%)
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP-------KTLIKSRSL 823
S + +E+ ++ L ID++ ++ E + E LH + Q++ ++L+ +
Sbjct: 1348 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEI 1407
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK---KLQLLKNA--KSLR 878
+ S + + D+ +++ IE+ ++L+ +++ EAD + E++ + KNA K
Sbjct: 1408 EKSLKHHEDIVDEIECIEK--TLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTD 1465
Query: 879 SDKALDLNTKKTTQLENELKEALAKI----KELEMICQDEK--SEKKVRFTEATKKETDT 932
+ ++L +LE +E + ++L + D K + K++ E K+
Sbjct: 1466 AKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKI 1525
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
+ +K Q ++ + + + + + +L+K+
Sbjct: 1526 VAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKL 1585
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
+ + EM V+ + G +E+ + + + +++ L ++E T + N ++ E
Sbjct: 1586 KSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR-E 1644
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
+ L + + +G+ +V ++ K + + + + + E ++ Q++K +LKN
Sbjct: 1645 VKSLLEELSFQKGELNVQISERK---TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNI 1701
Query: 1112 TSL----QTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKN---KLLKEVG 1164
+ + +++N +I Q + + K++
Sbjct: 1702 LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
Query: 1165 DKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI 1224
++ K+ + C +E ++D VLA +
Sbjct: 1762 ERDKREIERMTAESRALQSC--VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM 1819
Query: 1225 ELTS-EKDELQARFIKTE-----SKFITLEAEMRDLKADYENK---ITSLESTIAAKDVH 1275
E ++ EK EL R ++ E ++L ++ ++ + K + SL+ +A H
Sbjct: 1820 EQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDH 1879
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAES 1335
+ + L TT + D S E ++ Q E + +L+ + E
Sbjct: 1880 LNLAKQDLLHTTKHQ-DVLLS--EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI 1936
Query: 1336 SAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR 1395
KL++ Q + +L+ + + +L+ +L ++ KLD++
Sbjct: 1937 EENKLKLVQQEMMFQRLQKERESEESKLETSKVT---LKEQQHQLEKELTDQKSKLDQVL 1993
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+A ++ V+ E + K L Q ++R +L ++ E + L+ +
Sbjct: 1994 SKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELL-ALQKEADSMR 2052
Query: 1453 AEYEELTGKY----ELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
A++ L ++ + E++ K L +++ Q + LL ++E S E+ T++
Sbjct: 2053 ADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE 2109
>Y12490-1|CAA73095.1| 1979|Homo sapiens Golgi-associated
microtubule-binding protein protein.
Length = 1979
Score = 74.9 bits (176), Expect = 3e-12
Identities = 197/1053 (18%), Positives = 419/1053 (39%), Gaps = 108/1053 (10%)
Query: 137 LTGPLPDLDTGQTTNGSQTQLAITKNDSLAERVRKMQ-LLKTQNSFEKEPSIEKERERRS 195
LTG + + G++ ++ DS + + + +L+++N K+ + E E+
Sbjct: 26 LTGQISNFTKDMLMEGTE-EVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLE-EKHE 83
Query: 196 LSKSKEDEKTARYKDERSSTKDDVNFLM--------QVKNSRNSTNLKPPVRGGPXXXXX 247
S+ + +++ Y+++ + +++ L Q+ +++ P G P
Sbjct: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTAS 143
Query: 248 XXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDT 307
D ++ ++ D I +QE++ L R+E E R +A
Sbjct: 144 SSFAYGISHHPSAFHDDDM-DFGDIISS-QQEINRLSNEVSRLESEVGH--WRHIAQTSK 199
Query: 308 ANKYTTGRSSEVLKLQQKVNEL-------------------TTHNEDL-------RDEKK 341
A SE+ KLQ + EL H + L R+E
Sbjct: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
Query: 342 HLTQKIREIESELETRPS--TEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLX 399
++I E+E+ L+ S E +I +++ + + E + E ++ +++D+
Sbjct: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDIN 319
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKL 459
+N R+ E L E Q ++ C L + K + A + E E+ L
Sbjct: 320 KKLSS-AENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERIL 378
Query: 460 LEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF------TGSNPSLMKV 513
+ + + + + + E E+ R + +L LAE N K SL+
Sbjct: 379 AQSASVEEVFRLQQALSDAENEIMRLS--SLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQ 436
Query: 514 PQPE----------TVKVSRSSLTRGGSQEDPAQLLRDLQDSLE-READLREQLRNAEEE 562
+ E +V +S+ TR S + L DL+ +LE +E +L + + E
Sbjct: 437 EKEELQMSLLKLNNEYEVIKSTATRDISLDSE---LHDLRLNLEAKEQELNQSISEKETL 493
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
A ++++ Q T +++ I + + + + +I + EK L
Sbjct: 494 IAEIEELD----RQNQEATKHMIL--IKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLE 547
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK-----MATKARS 677
DK + L I + +A N+L T ++E+ E+L+ QL K ++ + +
Sbjct: 548 DDKMDITKELDVQKEKL-IQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKEN 606
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMK-LLLELNEQEATVLRRKVEELEQDKE 736
+L N+ + + + ++ + K LL+ E E L++ + ELEQ E
Sbjct: 607 LELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNE 666
Query: 737 ALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER---VKVLEDEIDEVRKKL 793
LKK ++ + + L N N+L+ E+ V+ L+ E E+ +L
Sbjct: 667 NLKKVAFDVKMENEKLVLACEDVRHQLEECLAGN-NQLSLEKNTIVETLKMEKGEIEAEL 725
Query: 794 IEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ--NVDLKRQLQVIEQEASVLRAKT 851
++ RL E + +K + L +R+L+ S Q + L + Q + E + L+
Sbjct: 726 CWAKK---RLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNI 782
Query: 852 QSLEADNEKLQ-------TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
+ ++ D+++ + E K+L L N K + +K + ++K +L+ + +AL K
Sbjct: 783 EQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD-KYSQALRKN 841
Query: 905 KELEMICQDEKSEKKVRFTEAT---KKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT- 960
+ L +EK E ++E + L+ +Q + +
Sbjct: 842 EILRQTI-EEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQ 900
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK 1020
L ++K+ ++ K +K+QL + +++ + E+ E + + ++ +
Sbjct: 901 LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLE 960
Query: 1021 -----TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDK-DVFANKYK 1074
L+K I++I+++L + + + + + E K++ +N + +K D+ + +
Sbjct: 961 KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQE-TKVQSLNIENGSEKHDLSKAETE 1019
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
L + K L E+ + QI++LS D
Sbjct: 1020 RLVKGIKERELEIKLLNEKNISLTKQIDQLSKD 1052
Score = 64.5 bits (150), Expect = 4e-09
Identities = 282/1457 (19%), Positives = 550/1457 (37%), Gaps = 134/1457 (9%)
Query: 154 QTQLAITKNDSLAERVR-KMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDER 212
Q QL + K + E K++ K Q S K+ E+ER L++S E+ R +
Sbjct: 336 QEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKER-ILAQSASVEEVFRLQQAL 394
Query: 213 SSTKDDVNFLMQVK--NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSN----- 265
S ++++ L + NS NLK +R L+ N
Sbjct: 395 SDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEV 454
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKE------KSDILLRRLANIDTANKYTTGRSSEV 319
+K + L E+ LR E E+E + + L+ + +D N+ T +
Sbjct: 455 IKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILI 514
Query: 320 L-KLQQKVNE----LTTHNEDLRDEKKHLTQ---KIREIESELETRPSTEAQTR-QIEQL 370
+L ++ NE ++ +DL DEKK + Q +I EL+ + Q+ + L
Sbjct: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
Query: 371 RAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN 430
E E L+D+ ++ + ++++ R+++ +E S +R EL Q++
Sbjct: 575 HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNE-EELSRIRNELMQSLNQ 633
Query: 431 CRVLSFK---LKKTERKADQLEQE--KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARS 485
+FK LK+ E + L+Q + E + L+ V M+ E + E +V
Sbjct: 634 DSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACE-DVRHQ 692
Query: 486 TEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL---RDL 542
E L +L+ + + + E + L E + L R+L
Sbjct: 693 LEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNL 752
Query: 543 QDS-LEREADLREQLRNAEE-ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ 600
S L+ E + +L ++ E A K+ D + T ++++ + E + +T I
Sbjct: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE-TKDVLSSSLEEQKQLTQLIN 811
Query: 601 NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED 660
K I KE+S +DK ++ + + L + ++++ ++E+
Sbjct: 812 KKEIFIEKL---KERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE 868
Query: 661 NESLLLQLKKMATKARSRKL-SPTPPANKLS-IETANDNDEKET-------DEADPAEMK 711
E L + + A A + L S T A+++S + T ++ E+E ++ + ++M+
Sbjct: 869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQ 928
Query: 712 LLLELNEQ--EATVLRRKVEE---------LEQDKE--ALKKQVKELTSKISSVTKTSAG 758
LL L EQ E R + E+ LE+D+E +L+K ++++ +++ +
Sbjct: 929 LLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQT 988
Query: 759 SNT-----TARRSLTTNS-------NKLAEER----VKVLEDEIDEVRKKLIEKERDCER 802
N+ T +SL + +K ER +K E EI + +K I + ++
Sbjct: 989 DNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQ 1048
Query: 803 LHAE-----LSLAQKKPKTL--IKSRSLDASDQQNVD-LKRQLQVIEQEASVLRAKTQSL 854
L + + Q+K + + +R S Q+V L++QLQ E + A
Sbjct: 1049 LSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEK 1108
Query: 855 EADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK-IKELEMICQD 913
+N L+TE K+ + AK K D N K +T+ E+ ++ + I+ L I +
Sbjct: 1109 TRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR- 1167
Query: 914 EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK--S 971
EK + ++K L Q Q K LK +K
Sbjct: 1168 ---EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSHQFEELLQERDK-LKQQVKKMEE 1223
Query: 972 FKPRIPKKPTDLT-TKLQLKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEK 1025
+K ++ ++ QL++ + L+ ++ + + GL +TKL K
Sbjct: 1224 WKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKL-K 1282
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN-LS 1084
+ +++ + + N K+ L + KL ++ +L + + L S LS
Sbjct: 1283 NFGQELAQVQHSIGQLCNTKDLL---LGKLDIISPQLSSASLLTPQSAECLRASKSEVLS 1339
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
+ L +E++ + + A ++ +SD +
Sbjct: 1340 ESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK 1399
Query: 1145 Q-VDNYTKIDQDKNKLLKEVGDK--------TKKIGDXXXXXXXXXXXCKRI---EKQLS 1192
+ D K+ ++K+ L+K D+ T K+ + +RI E +
Sbjct: 1400 EKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIG 1459
Query: 1193 TRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMR 1252
K + L T+ + S+ L ++ E + K + F L E
Sbjct: 1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALA-FEQLLKEKE 1518
Query: 1253 DLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS-PVEMVEMRXXXXXXX 1311
K N++ + ++ K V +Q D + K E T+ E+ +R
Sbjct: 1519 QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSN 1578
Query: 1312 XXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSS 1371
++ L ++ + E+ AA+ A+L+ + LE +S
Sbjct: 1579 QELERLRNHLLESE---DSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQAS 1635
Query: 1372 YWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRIT 1431
+E + +R + + VK LA L+ L+ +Q
Sbjct: 1636 VQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQ---------- 1685
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ 1491
E K Y ++K + +A K E L GK L+E + +A ++ E L V+
Sbjct: 1686 EEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQE--CLDEANAALDSASRLTEQLDVK 1743
Query: 1492 KELSTALGEIKTLQEKL 1508
+E L L++++
Sbjct: 1744 EEQIEELKRQNELRQEM 1760
Score = 59.7 bits (138), Expect = 1e-07
Identities = 270/1558 (17%), Positives = 591/1558 (37%), Gaps = 121/1558 (7%)
Query: 306 DTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELET----RPSTE 361
D + Y ++ +VL+++ KV E T E L D+ K + +K+ E++ + +
Sbjct: 283 DLSKIYEMQKTIQVLQIE-KV-ESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
Query: 362 AQTRQI-EQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--------ED 412
+ RQI E+ L L + +++ M ++ R L +++ FR E+
Sbjct: 341 VEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSAS-VEEVFRLQQALSDAEN 399
Query: 413 QADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRE 472
+ SSL ++ N + L +++ E++ L QEK E + LL++ + ++
Sbjct: 400 EIMRLSSLNQDNSLAEDNLK-LKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKST 458
Query: 473 -NRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ-----PETVK---VSR 523
R L+ E+ ++ L L+ + E N + + ++ + E K + +
Sbjct: 459 ATRDISLDSELH---DLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIK 515
Query: 524 SSLTRGGSQEDP--AQLLRDLQDSLER-------EADLREQLRNAEEETANCKQVNPPTF 574
L++ ++ D ++L +DL D +R + D+ ++L +E+ +
Sbjct: 516 DQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLH 575
Query: 575 LDKQVMTDNI--VTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS--IDKTTEET 630
L KQ + D + + +++S+ SIQ + + E+ S + + +++
Sbjct: 576 LTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDS 635
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMA--TKARSRKLSPTPPANK 688
+F L NL++ + +E+ NE+L KK+A K + KL +
Sbjct: 636 NSNFKDTLLKE-REAEVRNLKQNLSELEQLNENL----KKVAFDVKMENEKLVLACEDVR 690
Query: 689 LSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSK 748
+E + + + E + L +E E EA + K LE+ + +K ++EL++
Sbjct: 691 HQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANK-YEKTIEELSNA 749
Query: 749 ISSVTKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEKERDCERL 803
+ T + + ++AE E++ E +V +E+++ +L
Sbjct: 750 RNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQL 809
Query: 804 --HAELSLAQKKPKTLIKSRSLDASDQ---QNVDLKRQLQVIEQEASVLRAKTQSLEADN 858
E+ + + K ++ LD Q +N L++ ++ ++ ++ + L+ +
Sbjct: 810 INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEEL 869
Query: 859 EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEK 918
E+L+ E + + + K+L S L + ++ L+E +IK + I +D+ K
Sbjct: 870 ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEE---EIKHHQKIIEDQNQSK 926
Query: 919 K--VRFTEATKKETDTLKSK-QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
++ + KKE D + + + Q T++ +K + +
Sbjct: 927 MQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEE-RQD 985
Query: 976 IPKKPTDL--TTKLQLKKMVEDLEC-EIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRS 1032
I +D+ TK+Q + E ++ + G+ +E+ K EK I +
Sbjct: 986 IQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQ 1045
Query: 1033 --KLSKND-SEFTNEKNRLQTEIAKLKDVNAKLEGDKDV--FANKYKALENENSNLSNQC 1087
+LSK++ + T + EI L + +DV + +A E +
Sbjct: 1046 IDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVL 1105
Query: 1088 KTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
T E + + + +K+ + + + D +
Sbjct: 1106 NEKTRENSHLKTEYHKMMDIVAAKEAALIKLQD-----ENKKLSTRFESSGQDMFRETIQ 1160
Query: 1148 NYTKIDQDKNKLLKEVGDKTKKI----GDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXX 1203
N ++I ++K+ + + K + + + E+ L R D++
Sbjct: 1161 NLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSHQFEELLQER-DKLKQQVK 1219
Query: 1204 XXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKIT 1263
Q + + S +L E +LQA+ + L+ + L YE T
Sbjct: 1220 KMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNET 1279
Query: 1264 SLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNN 1323
L++ + Q++ ++ Q N K D ++++ + +
Sbjct: 1280 KLKNF----GQELAQVQHSIGQLCNTK-DLLLGKLDIISPQLSSASLLTPQSAECLRASK 1334
Query: 1324 AKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD 1383
+++ E +E + L+ A + S + ++ D++
Sbjct: 1335 SEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSE 1394
Query: 1384 LQSERKKLDRM-RIAHDKD--VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEET 1440
++ ++K D + ++ +KD +K K +L + + + +T LK E
Sbjct: 1395 IKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLK----ER 1450
Query: 1441 VKKLEHSLALEKAEYEELTGKYELLEEEHVV---TKARLTVEKEQAQGELLHVQKELSTA 1497
+ LE + K E E++ Y E E+ T + ++ + + E H KE + A
Sbjct: 1451 ILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFE-CHSMKEKALA 1509
Query: 1498 LGEI--KTLQEKLGTESAAWNTEKTEMQNSIASLQER----LCGGGWEVERARLNARLDQ 1551
++ + Q K G + N K+ + ++ QER L ++E L + +
Sbjct: 1510 FEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQR 1569
Query: 1552 -RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXX 1610
R++E R +N + L +H D R +K+++
Sbjct: 1570 LRDKEFR-SNQELERLRNHLLESEDSYTREALAAED--REAKLRKKVTVLEEKLVSSSNA 1626
Query: 1611 XXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
Q+ + + + Q + +L QV ++ N + +LE Q+
Sbjct: 1627 MENASHQA-SVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQ 1685
Query: 1671 SMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL- 1729
+ + + + + + E KV L++ CL DE + AS+L +L
Sbjct: 1686 EEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQE---CL-DEANAALDSASRLTEQLD 1741
Query: 1730 VSEKSSAEV-RLAEMQSRLNEYEEERLLS---SGRARVAGLATRMELAWHKERDEQQR 1783
V E+ E+ R E++ + + +++L+S S +V + R H + QR
Sbjct: 1742 VKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQR 1799
Score = 45.6 bits (103), Expect = 0.002
Identities = 113/623 (18%), Positives = 250/623 (40%), Gaps = 47/623 (7%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
Q E L QE D L+++ +++E+ K ++ + + E+ +LQ +V +
Sbjct: 1203 QFEELLQERDKLKQQVKKMEEWKQQVM----TTVQNMQHESAQLQEELHQLQAQVLVDSD 1258
Query: 332 HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDM 391
+N L+ + L Q + E++L+ + + Q++ +L + L L+ + + +
Sbjct: 1259 NNSKLQVDYTGLIQSYEQNETKLK---NFGQELAQVQHSIGQLCNTKDL---LLGKLDII 1312
Query: 392 KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
+L + R +++ S L+Q ++ +L+K+ ++ D +
Sbjct: 1313 SPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELE-------ELRKSLQEKDATIRT 1365
Query: 452 KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLM 511
E+ +L + + ++R+ ++ + E+ + E LQ+ L E + + L+
Sbjct: 1366 LQENNHRLSDSIAATSELERKEH-EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLL 1424
Query: 512 KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS-LEREADLREQLRNAEEETANCKQVN 570
+ T KV+ + L R Q + +L++ L E D+ + L+ E+ +
Sbjct: 1425 SSNENFTNKVNENELLR--------QAVTNLKERILILEMDIGK-LKGENEKIVETYRGK 1475
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS----IDKT 626
+ Q T+ + + E E +S++ K + KE+ + L+ K+
Sbjct: 1476 ETEYQALQE-TNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKS 1534
Query: 627 TEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN-ESLLLQLKKMATKARSRKLSPTPP 685
+E F + + + TA + E + + + R+ L
Sbjct: 1535 MQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDS 1594
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR--KVEELEQDKEALKKQVK 743
+ ++ A D + K + E KL+ N E + +VE L++ + KQ
Sbjct: 1595 YTREAL-AAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
Query: 744 ELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERL 803
E ++S V++ + +L +E + E+++ ++ + E +++ E L
Sbjct: 1654 ETALQLS-VSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENL 1712
Query: 804 HAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQT 863
++ Q+ + +LD++ + L QL V E++ L+ + E E L
Sbjct: 1713 EGKVISLQECLDEA--NAALDSASR----LTEQLDVKEEQIEELKRQN---ELRQEMLDD 1763
Query: 864 ENKKLQLLKNAKSLRSDKALDLN 886
KKL L N+ + DK L N
Sbjct: 1764 VQKKLMSLANSSEGKVDKVLMRN 1786
Score = 45.2 bits (102), Expect = 0.002
Identities = 149/840 (17%), Positives = 316/840 (37%), Gaps = 73/840 (8%)
Query: 732 EQDKEALKKQVKELTSKIS-----SVTKTSAGSNTTARRSLTTNSN---KLAEERVKVLE 783
+Q+ L +V L S++ + T + G++ + + + N +L + R + ++
Sbjct: 171 QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEID 230
Query: 784 D---EIDEVRKKLIEKERDCERLHAE-LSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
D E+ ++ +K + R H E LS +++ + L S DL + +
Sbjct: 231 DHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSK---I 287
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
E + ++ + + +E+ + Q E+K + K S +D+ D+ ++ QL E ++
Sbjct: 288 YEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDR--DILRREQEQLNVEKRQ 345
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+ + + L++ C + + T+KE +S +
Sbjct: 346 IMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLS 405
Query: 960 TLK---SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
+L SL +D K K RI + + Q K+ ++ ++ Y V+K+
Sbjct: 406 SLNQDNSLAEDNLK-LKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTA----- 459
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFT---NEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
T L+ E+ ++R L + E +EK L EI +L N + + ++
Sbjct: 460 -TRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQL 518
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT-SLQTTMSDCMXXXXXXXXXX 1132
+NE ++ ++ K +++ + + ++++L D + T L +
Sbjct: 519 SKQQNEGDSIISKLK---QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLH 575
Query: 1133 XXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLS 1192
VD K + + KE + + I RI +L
Sbjct: 576 LTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI-------RQNEEELSRIRNELM 628
Query: 1193 TRKDRVTXXXXXXXXXXXQAVVLANTHRRLS-IELTSEKDELQARFIKTESKFITLEAEM 1251
++ + + + N + LS +E +E + A +K E++ + L E
Sbjct: 629 QSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACE- 687
Query: 1252 RDLKADYE-----NKITSLESTIAAKDVHIK--QLEDALRQTTNDKYDEATSPVEMVEMR 1304
D++ E N SLE + + ++ ++E L +EA + +E
Sbjct: 688 -DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEEL 746
Query: 1305 XXXXXXXXXXXXXQDELNNAKIKL-EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXX 1363
+ E IKL +K + E + K + Q+ +D + ++
Sbjct: 747 SNARNLNTSALQLEHE---HLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQ 803
Query: 1364 XXXXXXSSYWE---NKAKELDTDLQSERKKLDRMRIAHD---KDVKNKDAELATLKGKLK 1417
+ E K KE + LQ E K + ++ + ++ KD L ++K
Sbjct: 804 KQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMK---- 859
Query: 1418 ILEQNSGAGAKRITELKQEYEETV----KKLEHSLALEKAEYEELTGKYELLEEEHVVTK 1473
E+N+ + + L++E T K S+ +E +L E LEEE +
Sbjct: 860 --EENNHL-QEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEE-IKHH 915
Query: 1474 ARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERL 1533
++ ++ Q++ +LL +E + E + E++ EK E S+ E++
Sbjct: 916 QKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQI 975
Score = 41.5 bits (93), Expect = 0.030
Identities = 135/762 (17%), Positives = 283/762 (37%), Gaps = 66/762 (8%)
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENEN 1080
++LE E+ R + ++ T+ + Q+EI KL+++ +L+ ++ + + ++E
Sbjct: 182 SRLESEVGHWRHIAQTSKAQGTDNSD--QSEICKLQNIIKELKQNRSQEIDDH---QHEM 236
Query: 1081 SNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXX 1140
S L N + E+ R + +L + + + +
Sbjct: 237 SVLQNAHQQKLTEISRRHRE------ELSDYEERIEELENLLQQGGSGVIETDLSKIYEM 290
Query: 1141 XXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTX 1200
QV K++ K ++++ DK K I +R ++QL+ K ++
Sbjct: 291 QKTIQVLQIEKVESTKK--MEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIME 348
Query: 1201 XXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF----ITLEAEMRDLKA 1256
+ L + + S +T EK+ + A+ E F +AE ++
Sbjct: 349 ECENLKLECSK---LQPSAVKQSDTMT-EKERILAQSASVEEVFRLQQALSDAENEIMRL 404
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
N+ SL + I+ LE + +K + S +++
Sbjct: 405 SSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDIS 464
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENK 1376
EL++ ++ LE E E + + E L +++ +L+ S +N+
Sbjct: 465 LDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE 524
Query: 1377 A----KELDTDLQSERKKL-----DRMRIAHDKDV-KNKDAELATLKGKLKILEQNSGAG 1426
+L DL E+K++ D+M I + DV K K + L + +Q
Sbjct: 525 GDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDK 584
Query: 1427 AKRITE-LKQEYEETVKKLEHSLALE---KAEYEELTG-KYELLE----EEHVVTKARLT 1477
+ + + L + E V + +L L+ + EEL+ + EL++ + + K L
Sbjct: 585 VENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLL 644
Query: 1478 VEKE-------QAQGELLHVQKELSTALGEIKTLQEKL--GTESAAWNTEKTEMQNSIAS 1528
E+E Q EL + + L ++K EKL E E+ N+ S
Sbjct: 645 KEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLS 704
Query: 1529 LQERLCGGGWEVERARLNARLD-QRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDY 1587
L++ ++E+ + A L ++R L AN +E + ++
Sbjct: 705 LEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIE---ELSNARNLNTSALQLEH 761
Query: 1588 ERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSL 1647
E + K+ + ++++ + + + K + +N ++ L
Sbjct: 762 EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQ-LINKKEIFIEKL 820
Query: 1648 HNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQ 1707
+ S+ + E D Y Q L + I+ D+ S+ S EE L+++
Sbjct: 821 KERSSKLQEELDKYSQALRKNEILRQTIEEKDR-------SLGSMKEENNH-----LQEE 868
Query: 1708 VACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNE 1749
+ L +E + +A + V+E +S +L ++ L E
Sbjct: 869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEE 910
>AF022655-1|AAC06349.1| 2442|Homo sapiens cep250 centrosome associated
protein protein.
Length = 2442
Score = 74.9 bits (176), Expect = 3e-12
Identities = 236/1355 (17%), Positives = 537/1355 (39%), Gaps = 89/1355 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
V+ + ++ Q++GL ++L +++ S ++ ++ + T ++ EV++
Sbjct: 748 VERDRQDLAAQLQGLSSAKELLESSLFEAQQQNS-VIDEPQGQLEVQIQTVT-QAKEVIQ 805
Query: 322 LQQKVN--ELTTHNEDLRDEKKHLTQKIREIESELETRPSTE--AQTRQIEQLRAKLLAA 377
+ + EL T E+ +++ + E E +T + A +++ QLR K
Sbjct: 806 GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWE-- 863
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSF 436
+E +++ K L L ++ +E Q + E +RE E+T +
Sbjct: 864 ----KERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL-EQEVARSTEVALR-LQR 494
+L+ TE++ L + + +K+L + + ++++ ++++L EQE + L+ QR
Sbjct: 920 QLE-TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED-PAQLLRDLQDSLER--EAD 551
EL EA + +L Q E+ + + + ED +QL+ QD +R E +
Sbjct: 979 ELKEAARQHRDDLAAL----QEESSSLLQDKMDLQKQVEDLKSQLVA--QDDSQRLVEQE 1032
Query: 552 LREQLRNAEEETANCKQVN-PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
++E+LR +E K++ L +M + E++++ + +
Sbjct: 1033 VQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEA 1092
Query: 611 SSKEKSDSPPLSI-DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE---EDNESLLL 666
++K S + + + +E + F + + A+++ + R ++ ++ L
Sbjct: 1093 QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL 1152
Query: 667 QLKKMATKARSRKLSPTP-PANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
L+ +T+++ L+ P N+ + + +A + + EL+ +
Sbjct: 1153 HLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA-- 1210
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
V LE D+ + L + +T SA + +A L + K + R VL D+
Sbjct: 1211 PSVWGLEPDQNG----ARSLFKRGPLLTALSAEAVASALLKLHQDLWKTQQTR-DVLRDQ 1265
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ ++ ++L + E + ++H EL Q++ + +S +QN L+ +L + + +
Sbjct: 1266 VQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS-KWEGKQN-SLESELMELHETMA 1323
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD--KALDLNTKKTTQLENELKEALAK 903
L+++ + E + Q E + LQ K + + + +A + + L+E L
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT 1383
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
+ + +E ++ R +A +++ + LK Q + +++
Sbjct: 1384 ARSALKLKNEEVESERER-AQALQEQGE-LKVAQ--GKALQENLALLTQTLAEREEEVET 1439
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
L+ Q+ K R +K L LKK ++++ + ++ + K + A +
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
E+++ R ++ + + + ++N L+ ++ +L+ + +E + + + L+ + L
Sbjct: 1500 EQKLTVQREQIREPEKDRETQRNVLEHQLLELEKKDQMIESQR----GQVQDLKKQLVTL 1555
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
L E E Q KL +L+ Q +
Sbjct: 1556 ECLALELEENHHKMECQ-QKLIKELEGQRETQRV---ALTHLTLDLEERSQELQAQSSQI 1611
Query: 1144 XQVDNY-TKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV---- 1198
++++ T + ++ + +EV + ++I + +R +++L +K+R+
Sbjct: 1612 HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
+ + R ELT+++ +Q R + + + +K
Sbjct: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 1259 ENKITSLESTIAAKDVH-IKQLEDALRQT---TNDKYDEATSPVEMVEMRXXXXXXXXXX 1314
+K +E + +H +++L+D L Q + K E + + E
Sbjct: 1732 RDKEKEVE--CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 1315 XXXQDELNNAKIKLEKTEAESSAA----KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXS 1370
Q EL ++ + EA+ + A +LE Q + A+ +
Sbjct: 1790 AREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQ 1849
Query: 1371 SYWENKAKELD-TDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
++ K + + D + + ++L+ + V+ + L L+ + + E+ A ++
Sbjct: 1850 AHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQ 1909
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEE-----HVVTKARLTVEKEQ-- 1482
E QE+E + L+ S +A +E + E L E H AR E Q
Sbjct: 1910 CAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEA 1969
Query: 1483 -------AQGELLHV--QKELSTAL-GEIKTLQEKLGTESAAWNTEKTEMQNSIASLQER 1532
QG+ H+ Q ELS +L TLQ L A + ++ +Q++
Sbjct: 1970 LGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQ 2029
Query: 1533 LCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
++ + +L L QR+ ELR +R +LE
Sbjct: 2030 --DLRYQEDVQQLQQALAQRDEELRHQQEREQLLE 2062
Score = 74.1 bits (174), Expect = 5e-12
Identities = 153/860 (17%), Positives = 350/860 (40%), Gaps = 53/860 (6%)
Query: 267 KEYQDQIEGLKQEVDILR-KRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
++Y+ I+ L++ V+IL E +E E S L R A + + + + +++
Sbjct: 300 EDYEKMIKALRETVEILETNHTELMEHEAS---LSRNAQEEKLSLQQVIKDITQVMVEEG 356
Query: 326 VN--ELTTHNEDLRDEKKHLTQ-KIREIESELETRPSTEAQTRQ-IEQLRAKLLAAETLC 381
N + + L E +Q ++ + L S + RQ ++ LR +L +
Sbjct: 357 DNIAQGSGLENSLELESSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV 416
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
L +++ ++E + L + R+ A + L+ E++ K +L ++
Sbjct: 417 NLLQQQHDQWEEEGKALRQRLQKLTGE-RDTLAGQTVDLQGEVDSLSKERELLQKAREEL 475
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
++ + LEQE + +E+ D Q + +E ++E+ + RLQ L +
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK--EEQQEELHLAVRERERLQEMLMGLEA 533
Query: 502 KFTGSNPSLMKVPQP-ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE---READLREQLR 557
K + S L+ + + E++ + L R E A L R Q E E L+ ++
Sbjct: 534 KQSESLSELITLREALESIHLE-GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
+ +N LDK + ++ + E S+ ++M A ++ +
Sbjct: 593 DLRAAAVKLSALNEALALDKVGLNQQLL-----QLEEENQSVCSRMEAAEQARNALQVDL 647
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
+ + E H + A L+ ++E+ E +++K +++R
Sbjct: 648 AEAEKRREALWEKNTHLEAQLQKA--EEAGAELQADLRDIQEEKE----EIQKKLSESRH 701
Query: 678 RKLSPTPPANKLSIETANDND-------EKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
++ + T +L E + EKE + A +++ L+ E++ L +++
Sbjct: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAAQLQG 761
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
L KE L+ + E + S + + + T + ++ + V+ L+ E+D R
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIDEPQG--QLEVQIQTVTQAKEVIQGEVRCLKLELDTER 819
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
+ E+ERD +L+ A+++ KT ++ + A+ ++ V+ R+ E+E S + +
Sbjct: 820 SQA-EQERDAAA--RQLAQAEQEGKTALEQQK--AAHEKEVNQLREKW--EKERSWHQQE 872
Query: 851 -TQSLEA-DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
++LE+ + EK++ E + + +++++ + + ++ + +L+ ++ LE
Sbjct: 873 LAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLE 932
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ Q +K +A+++ + + Q LK
Sbjct: 933 TLLQTQKE-----LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
+ + + L K+ L+K VEDL+ ++ + L +E+ K + +E +
Sbjct: 988 RDDLAALQEESSSLLQDKMDLQKQVEDLK---SQLVAQDDSQRLVEQEVQEKLRETQEYN 1044
Query: 1029 EIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
I+ +L + + T + + L++ ++ + + + + E LS Q +
Sbjct: 1045 RIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQME 1104
Query: 1089 TLTEEMKNREAQINKLSADL 1108
L +E+K +EA A L
Sbjct: 1105 LLRQEVKEKEADFLAQEAQL 1124
Score = 65.7 bits (153), Expect = 2e-09
Identities = 92/450 (20%), Positives = 196/450 (43%), Gaps = 22/450 (4%)
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVL 724
LLQL++ SR + N L ++ A +E ++ L+ E+ L
Sbjct: 619 LLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAEL 678
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLED 784
+ + +++++KE ++K++ E + + T + A+R + + E+ V E
Sbjct: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK 738
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
EVR + +E++R + L A+L K L++S SL + QQN VI++
Sbjct: 739 AALEVRLQAVERDR--QDLAAQLQ-GLSSAKELLES-SLFEAQQQN-------SVIDEPQ 787
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
L + Q++ E +Q E + L+L + + ++++ D ++ Q E E K AL +
Sbjct: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847
Query: 905 K---ELEMICQDEKSEKKVRF-TEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT 960
K E E+ EK EK+ + + K ++L+ ++ +
Sbjct: 848 KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE 907
Query: 961 LKSLKDDAQKSFKPRIPKKPTD-LTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTA 1019
++ + A + K+ L T LQ +K + D ++ + MK L +E T
Sbjct: 908 ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTG 967
Query: 1020 KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
L+ ++ E + +L + + ++ LQ E + L + K++ K V K + + +
Sbjct: 968 --ILQTQLQEAQRELKEAARQHRDDLAALQEESSSL--LQDKMDLQKQVEDLKSQLVAQD 1023
Query: 1080 NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+S + + + E+++ + + N++ +L+
Sbjct: 1024 DSQRLVE-QEVQEKLRETQ-EYNRIQKELE 1051
Score = 63.3 bits (147), Expect = 9e-09
Identities = 139/689 (20%), Positives = 293/689 (42%), Gaps = 72/689 (10%)
Query: 277 KQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDL 336
++EV+ LR + + +EK++ + A ++ + R+ EV Q+++ EL E
Sbjct: 1434 EEEVETLRGQIQELEKQRE----MQKAALELLSLDLKKRNQEVDLQQEQIQEL----EKC 1485
Query: 337 RDEKKHLTQKIREIESEL--------ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDEN 388
R +HL ++E E +L E E Q +E +L + + E +
Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIREPEKDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545
Query: 389 EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
+D+KK+L L +++N + + + L +ELE + RV L ++
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQ--KLIKELEGQRETQRV---ALTHLTLDLEER 1600
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
QE ++ ++ + RE ++E +QEV E LQR+ +
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLARE--LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ 1658
Query: 509 SLMKVPQPETVKVSRSSLTRGGS--QEDPAQLLRDLQDSLEREADLREQL--RNAEEETA 564
LM Q E ++V TR +ED Q+ L++ RE + QL AEE
Sbjct: 1659 ELML--QKERIQVLEDQRTRQTKILEEDLEQIKLSLRER-GRELTTQRQLMQERAEEGKG 1715
Query: 565 NCKQVNPPTFLDKQVMTD--NIVTCD---IHESETVTNSIQNKM--IH--AASTPSSKEK 615
K K ++ D V C IHE + + + ++ ++ +H T +
Sbjct: 1716 PSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQ 1775
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
+ + + + +E + +L S+ + + A + D E LQ ++ +
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLD----EAQRALAQRDQELEALQQEQQQAQG 1831
Query: 676 RSRKLSPTPPANKLSIETANDN-DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
+ ++ A + ++E A+ E+ + D E L E+E V R+V+ LE+
Sbjct: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRL---EEELAVEGRRVQALEEV 1888
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L+ + +E + ++ + A + E + L+D + + L
Sbjct: 1889 LGDLRAESREQEKALLALQQQCA------------EQAQEHEVETRALQDSWLQAQAVLK 1936
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRS---LDASDQQNVDLKRQLQVIEQEASV---LR 848
E++++ E L AE S + + + ++R+ +A + + L+ + Q + ++A + L
Sbjct: 1937 ERDQELEALRAE-SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE 1995
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
A T +L+A + Q +++L+ A ++ + D + + ++ +L++ALA+ ++ E
Sbjct: 1996 ASTATLQASLDACQAHSRQLE---EALRIQEGEIQDQDLRYQEDVQ-QLQQALAQ-RDEE 2050
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ Q E+ E+ + + A + + + ++ KQ
Sbjct: 2051 LRHQQER-EQLLEKSLAQRVQENMIQEKQ 2078
Score = 54.8 bits (126), Expect = 3e-06
Identities = 107/577 (18%), Positives = 216/577 (37%), Gaps = 45/577 (7%)
Query: 1213 VVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAK 1272
V LA +R L + L+A+ K E L+A++RD++ + E L + +
Sbjct: 645 VDLAEAEKRREA-LWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ 703
Query: 1273 DVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTE 1332
+ QLE ++ + A + E + + + + +L+
Sbjct: 704 EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAAQLQGLS 763
Query: 1333 AESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD 1392
+ + + + + + ++ + + + L +L +ER + +
Sbjct: 764 SAKELLESSLFEAQQQNSVIDEPQGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823
Query: 1393 RMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEE--TVKKLEHSLAL 1450
+ R A + + + E GK LEQ A K + +L++++E+ + + E + AL
Sbjct: 824 QERDAAARQLAQAEQE-----GKTA-LEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
Query: 1451 EKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT 1510
E E E++ + L E++ + + E+E+ Q E Q +L T + L+ L T
Sbjct: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
Query: 1511 E----SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVL 1566
+ A+ E+ + L+E+ G L +L + +REL+ A
Sbjct: 938 QKELADASQQLERLRQDMKVQKLKEQETTG-------ILQTQLQEAQRELKEA------A 984
Query: 1567 EHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEI 1626
H D D K+ + + E K
Sbjct: 985 RQHRDDLAALQEESSSLLQD-----KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
Query: 1627 TDTKTRYEGQMNTMRDELK-SLHNQVSRF--RRERDNYKQM-LEAAQKSMAEIKNGDKSA 1682
T R + ++ + L SL + R +E D+ +Q L A ++ M E + K
Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA---EVR 1739
+ +E + K A Q A L +EL S + +L L ++++ A +R
Sbjct: 1100 SAQMELL----RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLHLR 1155
Query: 1740 LAEMQSRLNEYEEERL---LSSGRARVAGLATRMELA 1773
L +S+L E+ + +A++A L + ++ A
Sbjct: 1156 LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Score = 48.8 bits (111), Expect = 2e-04
Identities = 132/678 (19%), Positives = 274/678 (40%), Gaps = 50/678 (7%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
++EG ++ + +E+S L + + I ++T + E+ + Q+V
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 332 HNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDM 391
E+L+ +K+HLTQ + + EL + + + + +E R + + L E+L +
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQ---KERIQVLEDQRTR--QTKILEEDLEQIKLSL 1692
Query: 392 KKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
++ R+L MQ+ E + + R LE R +++ + +L++
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPS-KAQRGSLEHMKLILRDKEKEVECQQEHIHELQEL 1751
Query: 452 KAEHEKKLLEI---VGGPDGM--QRENRIKELEQEVARSTEVA----LRLQRELAEANSK 502
K + E++L + VG + QRE I L+Q++ + E LQ +L EA
Sbjct: 1752 KDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRA 1811
Query: 503 FTGSNPSL------MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
+ L + Q + +V + G+ E L++ L+ D +EQ
Sbjct: 1812 LAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ---DHKEQA 1868
Query: 557 RNAEEETA-NCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
R EEE A ++V ++V+ D + + E E ++Q + A + +
Sbjct: 1869 RRLEEELAVEGRRVQAL----EEVLGD--LRAESREQEKALLALQQQCAEQAQEHEVETR 1922
Query: 616 S-DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
+ L +E +L L + + + AR E E+L + K
Sbjct: 1923 ALQDSWLQAQAVLKERD--QELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVL-RRKVEELEQ 733
L + L TA + +A +++ L + E E R E+++Q
Sbjct: 1981 -EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
Query: 734 DKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKL 793
++AL ++ +EL + + + A+R N + E++ LE E +E+R L
Sbjct: 2040 LQQALAQRDEELRHQ---QEREQLLEKSLAQR---VQENMIQEKQNLGLEREEEEIR-GL 2092
Query: 794 IEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS 853
+ R+ +L+LAQK+ + L + ++ + + + +E+++ L +
Sbjct: 2093 HQSVRE-----LQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR 2147
Query: 854 LEADNEKLQTENKKLQLLK-NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQ 912
L+ + E+LQ ++ + + + D AL L K + + + LE +
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE 2207
Query: 913 DEKSEKKVRFT-EATKKE 929
++ + ++ T A +KE
Sbjct: 2208 QQRLQDELELTRRALEKE 2225
Score = 44.4 bits (100), Expect = 0.004
Identities = 117/602 (19%), Positives = 237/602 (39%), Gaps = 44/602 (7%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDL----------KADYENKITSLESTIAAKDVH 1275
L + +L+ R TE++ + E++DL K+ +E K SLES +
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 1276 IKQLEDALRQTTNDKYDEATSPVEMVE-----MRXXXXXXXXXXXXXQDELNNAKIKLEK 1330
+ L+ LR+ + EA E+++ + + + + A I E
Sbjct: 1322 MASLQSRLRRAELQRM-EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 1331 TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
SA KL+ +++S+ E + EN A T L ++
Sbjct: 1381 LRTARSALKLKNEEVESER---ERAQALQEQGELKVAQGKALQENLALLTQT-LAEREEE 1436
Query: 1391 LDRMRIAHDKDVKNKDAELATLKG-KLKILEQNSGAGAKRITELKQEYEETVKKLEH-SL 1448
++ +R + K ++ + A L+ L + ++N ++ E QE E+ LEH +
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ--EQIQELEKCRSVLEHLPM 1494
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
A+++ E ++LT + E + E + + V + Q EL + + + G+++ L+++L
Sbjct: 1495 AVQERE-QKLTVQREQIREPEKDRETQRNVLEHQLL-ELEKKDQMIESQRGQVQDLKKQL 1552
Query: 1509 GT-ESAAWNTEKTEMQNSIASLQERLCGGGWEVERA---RLNARLDQRERELRAANDRRD 1564
T E A E+ + + G E +R L L++R +EL+A + +
Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIH 1612
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDY-ERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
LE H E++ ++QR E+ +
Sbjct: 1613 DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED 1672
Query: 1624 AEITDTKTRYEG--QMN-TMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN--G 1678
TK E Q+ ++R+ + L Q + + K +A + S+ +K
Sbjct: 1673 QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILR 1732
Query: 1679 DKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEV 1738
DK + + +E +++ LEQQ+ L ++ E+ LL S+ E+V + ++
Sbjct: 1733 DKEKEVECQQEHIHELQELKDQ---LEQQLQGLHRKVGETSLLLSQREQEIVVLQQ--QL 1787
Query: 1739 RLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERD---EQQRLLQETSTLARDL 1795
+ A Q L E + L + +A +E +++ +++R+ ++ L L
Sbjct: 1788 QEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL 1847
Query: 1796 RQ 1797
Q
Sbjct: 1848 EQ 1849
Score = 39.9 bits (89), Expect = 0.091
Identities = 70/331 (21%), Positives = 129/331 (38%), Gaps = 31/331 (9%)
Query: 1250 EMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
E +L E +L++++ A H +QLE+ALR + D+ E V+
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALA 2045
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
Q E LEK+ A+ + M Q K +L
Sbjct: 2046 QRDEELRHQQEREQL---LEKSLAQ--RVQENMIQEKQNLGLEREEEEIRGLHQSVRELQ 2100
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAK 1428
+ + + + L+ +R L+ + +H ++ + +L +L+ +L+ E A
Sbjct: 2101 LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQ-RELERLQAAL 2159
Query: 1429 RITELKQ-EYEETVKKLEHSLALEKAEYEEL--------------TGKYELLEEEHVVTK 1473
R TE ++ E+ E + L SLA KA L + + L++E +T+
Sbjct: 2160 RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTR 2219
Query: 1474 ARLTVEKEQAQGEL----LHVQKELSTALGEIKTLQEKL---GTESAAWNTEKTEMQNSI 1526
L E+ + G L + E LGE+ ++ + G E +W +Q ++
Sbjct: 2220 RALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAV 2279
Query: 1527 ASLQERLCGGGWEVERARLNARLDQRERELR 1557
A L+ + + +L + L+Q ERE R
Sbjct: 2280 ARLE--IDRSRLQRHNVQLRSTLEQVERERR 2308
Score = 38.3 bits (85), Expect = 0.28
Identities = 91/479 (18%), Positives = 199/479 (41%), Gaps = 48/479 (10%)
Query: 1327 KLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQS 1386
K ++ E E+ E+ QLKS LE S +N+ + + +++
Sbjct: 252 KTQELEKEAHERSQELIQLKSQ-GDLEKAELQDRVTELSALLTQSQKQNE--DYEKMIKA 308
Query: 1387 ERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKK--- 1443
R+ ++ + H ++ +A L+ + K+ Q K IT++ E + + +
Sbjct: 309 LRETVEILETNHT-ELMEHEASLSRNAQEEKLSLQQV---IKDITQVMVEEGDNIAQGSG 364
Query: 1444 LEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKT 1503
LE+SL LE + + + Y+ ++ + ++ LT ++ Q ++++L+ +
Sbjct: 365 LENSLELESSIFSQFD--YQDADKALTLVRSVLTRRRQAVQD----LRQQLAGCQEAVNL 418
Query: 1504 LQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRR 1563
LQ+ + W E ++ + ++L G ER L + + E+ + + R
Sbjct: 419 LQQ----QHDQWEEEGKALRQRL----QKLTG-----ERDTLAGQTVDLQGEVDSLSKER 465
Query: 1564 DVLEHHHDXXXXXXXXXXXXXXDYERVS-KIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR 1622
++L+ + RV+ ++Q + + E+ +
Sbjct: 466 ELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQ 525
Query: 1623 KAEITDTKTRYEG--QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDK 1680
+ + + E ++ T+R+ L+S+H + R+E+ L A++S+AE+ + +
Sbjct: 526 EMLMGLEAKQSESLSELITLREALESIHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585
Query: 1681 S-------ARIHRNSISSTDEEEYRNKVALLEQQVACLEDE---LCESRLLASKLNTELV 1730
+ R +S+ +E +KV L QQ+ LE+E +C A + L
Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVG-LNQQLLQLEEENQSVCSRMEAAEQARNALQ 644
Query: 1731 SEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA-WHKERDEQQRLLQET 1788
+ + AE R + + N + E +L +A AG + +L +E++E Q+ L E+
Sbjct: 645 VDLAEAEKRREALWEK-NTHLEAQL---QKAEEAGAELQADLRDIQEEKEEIQKKLSES 699
>AF007217-1|AAD09135.1| 1978|Homo sapiens Trip230 protein.
Length = 1978
Score = 74.9 bits (176), Expect = 3e-12
Identities = 200/1055 (18%), Positives = 421/1055 (39%), Gaps = 112/1055 (10%)
Query: 137 LTGPLPDLDTGQTTNGSQTQLAITKNDSLAERVRKMQ-LLKTQNSFEKEPSIEKERERRS 195
LTG + + G++ ++ DS + + + +L+++N K+ + E E+
Sbjct: 26 LTGQISNFTKDMLMEGTE-EVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLE-EKHE 83
Query: 196 LSKSKEDEKTARYKDERSSTKDDVNFLM--------QVKNSRNSTNLKPPVRGGPXXXXX 247
S+ + +++ Y+++ + +++ L Q +++ P G P
Sbjct: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQFLKLQSAAQSVPSGAGVPATTAS 143
Query: 248 XXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDT 307
D ++ ++ D I +QE++ L R+E E R +A
Sbjct: 144 SSFAYGISHHPSAFHDDDM-DFGDIISS-QQEINRLSNEVSRLESEVGH--WRHIAQTSK 199
Query: 308 ANKYTTGRSSEVLKLQQKVNEL-------------------TTHNEDL-------RDEKK 341
A SE+ KLQ + EL H + L R+E
Sbjct: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
Query: 342 HLTQKIREIESELETRPS--TEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLX 399
++I E+E+ L+ S E +I +++ + + E + E ++ +++D+
Sbjct: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDIN 319
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKL 459
+N R+ E L E Q ++ C L + K + A + E E+ L
Sbjct: 320 KKLSS-AENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERIL 378
Query: 460 LEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF------TGSNPSLMKV 513
+ + + + + E E+ R + +L LAE N K SL+
Sbjct: 379 AQSGSVEEVFRLRQALSDAENEIMRLS--SLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQ 436
Query: 514 PQPE----------TVKVSRSSLTRGGSQEDPAQLLRDLQDSLE-READLREQLRNAEEE 562
+ E +V +S+ TR S + L DL+ +LE +E +L + + E
Sbjct: 437 EKEELQMSLLKLNNEYEVIKSTATRDISLDSE---LHDLRLNLEAKEQELNQSISEKETL 493
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
A ++++ + M ++ + + + +SI +K+ + EK L
Sbjct: 494 IAEIEELDRQNQEATKHMI--LIKAQLSKQQNEGDSIISKL----KQDLNDEKKRVHQLE 547
Query: 623 IDK--TTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK-----MATKA 675
DK T+E F L I + +A N+L T ++E+ E+L+ QL K ++ +
Sbjct: 548 DDKMDITKELDVQF---VLLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQK 604
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK-LLLELNEQEATVLRRKVEELEQD 734
+ +L N+ + + + ++ + K LL+ E E L++ + ELEQ
Sbjct: 605 ENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQL 664
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER---VKVLEDEIDEVRK 791
E LKK ++ + + L N N+L+ E+ V+ L+ E E+
Sbjct: 665 NENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGN-NQLSLEKNTIVETLKMEKGEIEA 723
Query: 792 KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ--NVDLKRQLQVIEQEASVLRA 849
+L ++ RL E + +K + L +R+L+ S Q + L + Q + E + L+
Sbjct: 724 ELCWAKK---RLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
Query: 850 KTQSLEADNEKLQ-------TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA 902
+ ++ D+++ + E K+L L N K + +K + ++K +L+ + +AL
Sbjct: 781 NIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD-KYSQALR 839
Query: 903 KIKELEMICQDEKSEKKVRFTEAT---KKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
K + L +EK E ++E + L+ +Q +
Sbjct: 840 KNEILRQTI-EEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEV 898
Query: 960 T-LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
+ L ++K+ ++ K +K+QL + +++ + E+ E + + ++
Sbjct: 899 SQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLF 958
Query: 1019 AK-----TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDK-DVFANK 1072
+ L+K I++I+++L + + + + + E K++ +N + +K D+ +
Sbjct: 959 LEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQE-TKVQSLNIENGSEKHDLSKAE 1017
Query: 1073 YKALENENSNLSNQCKTLTEEMKNREAQINKLSAD 1107
+ L + K L E+ + QI++LS D
Sbjct: 1018 TERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD 1052
Score = 63.7 bits (148), Expect = 6e-09
Identities = 244/1288 (18%), Positives = 485/1288 (37%), Gaps = 109/1288 (8%)
Query: 273 IEGLKQEVDILRKRCERVEKEKSDI--------LLRRLANIDTANKYTTGRSSE--VLKL 322
I LKQ+++ +KR ++E +K DI +L + + + + T + E V L
Sbjct: 529 ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQFVLLIQSEVALNDLHLTKQKLEDKVENL 588
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCE 382
++N+ N ++ E L + IR+ E EL +R E + + +TL +
Sbjct: 589 VDQLNKSQESNVSIQKENLELKEHIRQNEEEL-SRIRNELMQSLNQDSNSNF--KDTLLK 645
Query: 383 ELMDENEDMKKELRDLXXXXXXMQD-NFREDQADEY-----SSLRRELEQTIKNCRVLSF 436
E E ++K+ L +L ++ F +E +R +LE+ + LS
Sbjct: 646 EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSL 705
Query: 437 K----LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
+ ++ + + ++E E +K+LLE + + E I+EL +T AL+L
Sbjct: 706 EKNTIVETLKMEKGEIEAELCWAKKRLLE-----EANKYEKTIEELSNARNLNTS-ALQL 759
Query: 493 QRE-LAEANSKFT------GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
+ E L + N K N M ET V SSL Q+ QL+ +
Sbjct: 760 EHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEE---QKQLTQLINKKEIF 816
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
+E+ L+E+ +EE Q + +Q + + + + E N +Q ++
Sbjct: 817 IEK---LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN--NHLQEELER 871
Query: 606 AASTPSSKEKSDSPPLSIDKTTEE-TQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESL 664
+E+S + P++ KT + T+ ++ L+ ++ +E+ N+S
Sbjct: 872 LR-----EEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSK 926
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVL 724
+ L+ + + + + E N + E D E+K L + EQ T L
Sbjct: 927 MQLLQSLQEQKKEMD------EFRYQHEQMNATHTQLFLEKDE-EIKSLQKTIEQIKTQL 979
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLED 784
+ ++++ D + ++ K + I + ++ S R + K E +K+L +
Sbjct: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV--KGIKERELEIKLLNE 1037
Query: 785 EIDEVRKKLIEKERD-CERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ + K++ + +D +L + + + L S + Q V L++QLQ E
Sbjct: 1038 KNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME 1097
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ A +N L+TE K+ + AK K D N K +T+ E+ ++ +
Sbjct: 1098 REKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRE 1157
Query: 904 -IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
I+ L I + EK + ++K L Q Q K
Sbjct: 1158 TIQNLSRIIR----EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDK 1213
Query: 963 SLKDDAQK--SFKPRIPKKPTDLT-TKLQLKKMVEDLECEI-----GEMYVVMKNAGLSG 1014
LK +K +K ++ ++ QL++ + L+ ++ + + GL
Sbjct: 1214 -LKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQ 1272
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK 1074
+TKL K + +++ + + N K+ L + KL ++ +L + +
Sbjct: 1273 SYEQNETKL-KNFGQELAQVQHSIGQLCNTKDLL---LGKLDIISPQLSSASLLTPQSAE 1328
Query: 1075 ALENENSN-LSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
L S LS + L +E++ + + A ++ +SD +
Sbjct: 1329 CLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH 1388
Query: 1134 XXXXXXXXXXXQ-VDNYTKIDQDKNKLLKEVGDK--------TKKIGDXXXXXXXXXXXC 1184
+ D K+ ++K+ L+K D+ T K+ +
Sbjct: 1389 EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLK 1448
Query: 1185 KRI---EKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
+RI E + K + L T+ + S+ L ++ E + K
Sbjct: 1449 ERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKAL 1508
Query: 1242 SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS-PVEM 1300
+ F L E K N++ + ++ K V +Q D + K E T+ E+
Sbjct: 1509 A-FEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEV 1567
Query: 1301 VEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXX 1360
+R ++ L ++ + E+ AA+ A+L+ + LE
Sbjct: 1568 QRLRDKEFRSNQELERLRNHLLESE---DSYTREALAAEDREAKLRKKVTVLEEKLVSSS 1624
Query: 1361 XXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE 1420
+S +E ++ S+++ +R VK LA L+ L+ +
Sbjct: 1625 NAMENASHQASVQVESLQE-QLNVVSKQRDETALRFCLSGTVKQYRLSLANLQMVLEHFQ 1683
Query: 1421 QNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEK 1480
Q E K Y ++K + +A K E L GK L+E + +A ++
Sbjct: 1684 Q----------EEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQE--CLDEANAALDS 1731
Query: 1481 EQAQGELLHVQKELSTALGEIKTLQEKL 1508
E L V++E L L++++
Sbjct: 1732 ASRLTEQLDVKEEQIEELKRQNELRQEM 1759
Score = 61.7 bits (143), Expect = 3e-08
Identities = 161/883 (18%), Positives = 347/883 (39%), Gaps = 80/883 (9%)
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSN 760
ETD + EM+ +++ + E +K+E+LE + + K++ + + + N
Sbjct: 281 ETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
Query: 761 TTARR------SLTTNSNKLAEERVKVLEDEIDEVRKKLIE--KERDCERLHAELSLAQK 812
R+ +L +KL VK D + E + L + + RL LS A+
Sbjct: 341 VEKRQIMEECENLKLECSKLQPSAVK-QSDTMTEKERILAQSGSVEEVFRLRQALSDAEN 399
Query: 813 KPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
+ L ++ + N+ LK +++V+E+E S+L + + L+ KL N + +++K
Sbjct: 400 EIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKL---NNEYEVIK 456
Query: 873 NAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT 932
+ + + L++EL + ++ E SEK+ E +E D
Sbjct: 457 STAT------------RDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEI--EELD- 501
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
+ Q + + LK D K R+ + D K+ + K
Sbjct: 502 -RQNQEATKHMILIKAQLSKQQNEGDSIISKLKQDLNDE-KKRVHQLEDD---KMDITK- 555
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI 1052
E ++ + ++ L+ +T K KLE +++ + +L+K+ + +Q E
Sbjct: 556 ----ELDVQFVLLIQSEVALNDLHLT-KQKLEDKVENLVDQLNKSQESNVS----IQKEN 606
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
+LK+ + E + N+ N++SN SN TL +K REA++ L +L
Sbjct: 607 LELKEHIRQNEEELSRIRNELMQSLNQDSN-SNFKDTL---LKEREAEVRNLKQNLSELE 662
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ-VDNYTKIDQDKNKLLKEVGDKTKKIG 1171
L + + + ++ +KN +++ + K +K G
Sbjct: 663 QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETL--KMEK-G 719
Query: 1172 DXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKD 1231
+ KR+ ++ + + ++ A+ L + H I+L +KD
Sbjct: 720 EIEAELCWAK---KRLLEE-ANKYEKTIEELSNARNLNTSALQLEHEH---LIKLNQKKD 772
Query: 1232 ELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED--ALRQTTND 1289
A K + T E +D+ + + L I K++ I++L++ + Q D
Sbjct: 773 MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD 832
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEK-TEAESSAAKL-------E 1341
KY +A E+ +R ++E N+ + +LE+ E +S A +
Sbjct: 833 KYSQALRKNEI--LRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDS 890
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+ +L S++++L +L LQ ++K++D R H++
Sbjct: 891 VTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQM 950
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
++K L++ ++ E +Q+ + + ++ E + K
Sbjct: 951 NATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEK 1010
Query: 1462 YEL--LEEEHVVTKAR-LTVEKEQAQGELLHVQKEL----STALGEIKTL--QEKLGTES 1512
++L E E +V + +E + + + + K++ +G++ + Q+ L ++
Sbjct: 1011 HDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQA 1070
Query: 1513 AAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
T + LQ++L + +ER ++ A L+++ RE
Sbjct: 1071 LHARISSTSHTQDVVYLQQQL--QAYAMEREKVFAVLNEKTRE 1111
Score = 61.7 bits (143), Expect = 3e-08
Identities = 187/893 (20%), Positives = 376/893 (42%), Gaps = 107/893 (11%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
++ ++E + +K+E + L++ ER+ +E+S R A + A+ T V
Sbjct: 843 ILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS-----RTAPV--ADPKTL---DSVT 892
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIRE--IESELETRPSTEAQTRQIEQLRAKLLAAE 378
+L +V++L T E L +E KH QKI E +S+++ S + Q +++++ R +
Sbjct: 893 ELASEVSQLNTIKEHLEEEIKH-HQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMN 951
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+L E ++ E++ L ++ E++ D ++ + + +V S +
Sbjct: 952 ATHTQLFLEKDE---EIKSLQKTIEQIKTQLHEERQD----IQTDNSDIFQETKVQSLNI 1004
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ K D KAE E+ +V G IKE E E+ E + L +++ +
Sbjct: 1005 ENGSEKHD---LSKAETER----LVKG---------IKERELEIKLLNEKNISLTKQIDQ 1048
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQD-SLERE---ADLRE 554
+ G +++ E ++ + ++ +D L + LQ ++ERE A L E
Sbjct: 1049 LSKDEVGKLTQIIQQKDLE-IQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNE 1107
Query: 555 QLR-NAEEETANCKQVNPPTFLDK---QVMTDNIVTCDIHES---ETVTNSIQN--KMIH 605
+ R N+ +T K ++ + ++ +N ES + +IQN ++I
Sbjct: 1108 KTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR 1167
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHM--AANNLRKTAARVEEDNES 663
L T T + F + + L++ ++EE +
Sbjct: 1168 EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQ 1227
Query: 664 LLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATV 723
++ ++ M + S +L ++L + D+D + D L++ EQ T
Sbjct: 1228 VMTTVQNM--QHESAQLQ--EELHQLQAQVLVDSDNNSKLQVDYTG---LIQSYEQNETK 1280
Query: 724 LRRKVEELEQDKEALKK--QVKE-LTSKISSVT-KTSAGSNTTARRS--LTTNSNKLAEE 777
L+ +EL Q + ++ + K+ L K+ ++ + S+ S T + + L + +++ E
Sbjct: 1281 LKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSE 1340
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
++L+ E++E+RK L EK+ A + Q+ L S S+ A+ +L+R+
Sbjct: 1341 SSELLQQELEELRKSLQEKD-------ATIRTLQENNHRL--SDSIAATS----ELERK- 1386
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL-ENE 896
E E + ++ + L+ + LQ K+ LL AK SD+ L N T ++ ENE
Sbjct: 1387 ---EHEQT--DSEIKQLKEKQDVLQKLLKEKDLLIKAK---SDQLLSSNENFTNKVNENE 1438
Query: 897 -LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
L++A+ +KE +I + + + K +K +T + K+
Sbjct: 1439 LLRQAVTNLKERILILEMDIGKLK----GENEKIVETYRGKETEYQALQETNMKFSMMLR 1494
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSG 1014
+ S+K+ A +F+ + +K T +L QL V+ ++ + L+
Sbjct: 1495 EKEFECHSMKEKA-LAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLAL 1553
Query: 1015 KE-MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRL-------QTEIAKLKDVNAKLEGDK 1066
K+ T L+ E+ +R K +++ E +N L E +D AKL
Sbjct: 1554 KQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKV 1613
Query: 1067 DVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
V K + N N S+Q E + + Q+N +S ++ T+L+ +S
Sbjct: 1614 TVLEEKLVSSSNAMENASHQASVQVESL---QEQLNVVSKQ-RDETALRFCLS 1662
Score = 58.8 bits (136), Expect = 2e-07
Identities = 273/1568 (17%), Positives = 593/1568 (37%), Gaps = 124/1568 (7%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ-QKV 326
E ++E L+ ++ + K+ E ++ DIL R ++ + E LKL+ K+
Sbjct: 303 ESTKKMEQLEDKIKDINKKLSSAENDR-DILRREQEQLNVEKRQIM-EECENLKLECSKL 360
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
D EK+ + + +E R + +I +L + L +L E+
Sbjct: 361 QPSAVKQSDTMTEKERILAQSGSVEEVFRLRQALSDAENEIMRL-SSLNQDNSLAED--- 416
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
N +K + L + +E+ L E E IK+ L + +
Sbjct: 417 -NLKLKMRIEVLEKEKSLLSQE-KEELQMSLLKLNNEYE-VIKSTATRDISL---DSELH 470
Query: 447 QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGS 506
L E++L + + + + E I+EL+++ +T+ + ++ +L++ ++
Sbjct: 471 DLRLNLEAKEQELNQSISEKETLIAE--IEELDRQNQEATKHMILIKAQLSKQQNEGDSI 528
Query: 507 NPSLMKVPQPETVKVSRSSLTRGG-SQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
L + E +V + + ++E Q + +Q + DL + E++ N
Sbjct: 529 ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQFVLLIQSEVALN-DLHLTKQKLEDKVEN 587
Query: 566 C-KQVNPPTFLDKQVMTDNIVTCD-IHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
Q+N + + +N+ + I ++E + I+N+++ + + S+ D+ L
Sbjct: 588 LVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDT--LLK 645
Query: 624 DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPT 683
++ E +L L N NL+K A V+ +NE L+L + + R +
Sbjct: 646 EREAEVRNLKQNLSELEQLNE----NLKKVAFDVKMENEKLVLACEDV----RHQLEECL 697
Query: 684 PPANKLSIE--TANDNDEKETDEADP----AEMKLLLELNEQEATV------LRRKVEEL 731
N+LS+E T + + E E + A+ +LL E N+ E T+ L
Sbjct: 698 AGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSAL 757
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
+ + E L K ++ +I+ + K +T + + S+ L E++ ++ +
Sbjct: 758 QLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQK---------QLTQ 808
Query: 792 KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+ +KE E+L S Q++ S++L ++N L++ ++ ++ ++ +
Sbjct: 809 LINKKEIFIEKLKERSSKLQEELDKY--SQAL----RKNEILRQTIEEKDRSLGSMKEEN 862
Query: 852 QSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMIC 911
L+ + E+L+ E + + + K+L S L + ++ L+E +IK + I
Sbjct: 863 NHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEE---EIKHHQKII 919
Query: 912 QDEKSEKK--VRFTEATKKETDTLKSK-QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+D+ K ++ + KKE D + + + Q T++ +K
Sbjct: 920 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
Query: 969 QKSFKPRIPKKPTDL--TTKLQLKKMVEDLEC-EIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
+ + I +D+ TK+Q + E ++ + G+ +E+ K EK
Sbjct: 980 HEE-RQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEK 1038
Query: 1026 EIDEIRS--KLSKND-SEFTNEKNRLQTEIAKLKDVNAKLEGDKDV--FANKYKALENEN 1080
I + +LSK++ + T + EI L + +DV + +A E
Sbjct: 1039 NISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER 1098
Query: 1081 SNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXX 1140
+ T E + + + +K+ + + + D
Sbjct: 1099 EKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQD-----ENKKLSTRFESSGQD 1153
Query: 1141 XXXXQVDNYTKIDQDKNKLLKEVGDKTKKI----GDXXXXXXXXXXXCKRIEKQLSTRKD 1196
+ N ++I ++K+ + + K + + + E+ L R D
Sbjct: 1154 MFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQER-D 1212
Query: 1197 RVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA 1256
++ Q + + S +L E +LQA+ + L+ + L
Sbjct: 1213 KLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQ 1272
Query: 1257 DYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX 1316
YE T L++ + Q++ ++ Q N K D ++++ +
Sbjct: 1273 SYEQNETKLKNF----GQELAQVQHSIGQLCNTK-DLLLGKLDIISPQLSSASLLTPQSA 1327
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENK 1376
+ +++ E +E + L+ A + S +
Sbjct: 1328 ECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKE 1387
Query: 1377 AKELDTDLQSERKKLDRM-RIAHDKD--VKNKDAELATLKGKLKILEQNSGAGAKRITEL 1433
++ D++++ ++K D + ++ +KD +K K +L + + + +T L
Sbjct: 1388 HEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNL 1447
Query: 1434 KQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVV---TKARLTVEKEQAQGELLHV 1490
K E + LE + K E E++ Y E E+ T + ++ + + E H
Sbjct: 1448 K----ERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFE-CHS 1502
Query: 1491 QKELSTALGEI--KTLQEKLGTESAAWNTEKTEMQNSIASLQER----LCGGGWEVERAR 1544
KE + A ++ + Q K G + N K+ + ++ QER L ++E
Sbjct: 1503 MKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTA 1562
Query: 1545 LNARLDQ-RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXX 1603
L + + R++E R +N + L +H D R +K+++
Sbjct: 1563 LQNEVQRLRDKEFR-SNQELERLRNHLLESEDSYTREALAAED--REAKLRK----KVTV 1615
Query: 1604 XXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELK---SLHNQVSRFRRERDN 1660
+E + ++ + + ++ RDE L V ++R N
Sbjct: 1616 LEEKLVSSSNAMENASHQASVQVESLQEQL-NVVSKQRDETALRFCLSGTVKQYRLSLAN 1674
Query: 1661 YKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRL 1720
+ +LE Q+ + + + + + + E KV L++ CL DE +
Sbjct: 1675 LQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQE---CL-DEANAALD 1730
Query: 1721 LASKLNTEL-VSEKSSAEV-RLAEMQSRLNEYEEERLLS---SGRARVAGLATRMELAWH 1775
AS+L +L V E+ E+ R E++ + + +++L+S S +V + R H
Sbjct: 1731 SASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGH 1790
Query: 1776 KERDEQQR 1783
+ QR
Sbjct: 1791 FHTPKNQR 1798
Score = 48.8 bits (111), Expect = 2e-04
Identities = 140/732 (19%), Positives = 270/732 (36%), Gaps = 78/732 (10%)
Query: 990 KKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQ 1049
++ + D E I E+ +++ G SG T +K+ E+ + L E T + +L+
Sbjct: 255 REELSDYEERIEELENLLQQGG-SGVIETDLSKIY-EMQKTIQVLQIEKVESTKKMEQLE 312
Query: 1050 TEIAKLKDVNAKL---EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
K+KD+N KL E D+D+ + + L E + +C+ L E + K S
Sbjct: 313 D---KIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSD 369
Query: 1107 DLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDK 1166
+ + DN D K K+ EV +K
Sbjct: 370 TMTEKERILAQSGSVEEVFRLRQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEK 429
Query: 1167 TKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRL--SI 1224
K + ++ + K T + L + L SI
Sbjct: 430 EKSL--LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSI 487
Query: 1225 E----LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE 1280
L +E +EL + + I ++A++ + + ++ I+ L+ + + + QLE
Sbjct: 488 SEKETLIAEIEELDRQNQEATKHMILIKAQLSKQQNEGDSIISKLKQDLNDEKKRVHQLE 547
Query: 1281 DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL 1340
D T + V +++ +D++ N +L K++ + + +
Sbjct: 548 DDKMDITKEL---DVQFVLLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQK 604
Query: 1341 EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK 1400
E +LK + + E S + L+ D S K D
Sbjct: 605 ENLELKEHIRQNEE-------------ELSRIRNELMQSLNQDSNSNFK---------DT 642
Query: 1401 DVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEE-LT 1459
+K ++AE+ LK L LEQ + K ++K E E+ V E + + EE L
Sbjct: 643 LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACED----VRHQLEECLA 698
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEI-KTLQEKLGTESAAWNTE 1518
G +L E++ + + L +EK + + EL +K L + KT++E + +
Sbjct: 699 GNNQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSAL 757
Query: 1519 KTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAAND-RRDVLEHHHDXXXXXX 1577
+ E ++ I Q++ ++E A L ++Q + + + D LE
Sbjct: 758 QLEHEHLIKLNQKK------DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLIN 811
Query: 1578 XXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEI-TDTKTRYEGQ 1636
ER SK+Q + S+ RK EI T +
Sbjct: 812 KKEIFIEKLKERSSKLQEELD-----------------KYSQALRKNEILRQTIEEKDRS 854
Query: 1637 MNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHR-NSISSTDEE 1695
+ +M++E L ++ R R E+ + A K++ + + ++ + + N+I EE
Sbjct: 855 LGSMKEENNHLQEELERLREEQSRTAPV--ADPKTLDSVT--ELASEVSQLNTIKEHLEE 910
Query: 1696 EYRNKVALLEQQ 1707
E ++ ++E Q
Sbjct: 911 EIKHHQKIIEDQ 922
>AY703984-1|AAV80770.1| 1581|Homo sapiens SP-A receptor subunit
SP-R210 alphaS protein.
Length = 1581
Score = 74.5 bits (175), Expect = 3e-12
Identities = 151/769 (19%), Positives = 313/769 (40%), Gaps = 66/769 (8%)
Query: 299 LRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETR 357
+R L + + + + E+ +L+ K+ + +LR L +I E+ SEL + R
Sbjct: 785 VRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 844
Query: 358 PSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDL------XXXXXXMQDNFRE 411
+ E+ ++ ++ A+ L AE +EL + + +KK++ + + N
Sbjct: 845 NTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEV 904
Query: 412 DQADEYSSLRRELEQTIKNCRVLSFKLKKT-ERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
D D R + E+ ++ +L++ E K + +Q K + E++L ++ D +
Sbjct: 905 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQA--DSEE 962
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGG 530
+ +++L+++ RL EL + G +V E K R +
Sbjct: 963 SQRALQQLKKK-------CQRLTAELQDTKLHLEG-----QQVRNHELEKKQRRFDSELS 1010
Query: 531 SQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
+ AQ + ++ L+RE D+ + ++ K ++ F K V + + DI
Sbjct: 1011 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ-DIS 1069
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTT----EETQFHFDLPYLSIFNHMA 646
E+ + K+ +K K L T E+ + ++ +
Sbjct: 1070 SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEME-MERMRQTH 1128
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSR---KLSPTPPANKLSIETANDNDEKETD 703
+ + VEE +S +LK+M + K +L + A +D+
Sbjct: 1129 SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1188
Query: 704 EADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+ + +E +L +L +A + + ++ L+ + K+++ +L +++ T A +
Sbjct: 1189 DFE-SEKRLRKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAA-V 1245
Query: 762 TARRSLTTNSNKL---AEERVK---VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK 815
AR+++ L ++ K LE+++ ++++ E + E +++ KK K
Sbjct: 1246 KARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHK 1305
Query: 816 TLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKN 873
+ S D + Q DL+ QL+ +E L+ K Q+L++ E L+ +K L +
Sbjct: 1306 AAVAQASRDLA--QINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQE 1363
Query: 874 AKSLRSDKALDL---NTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
AK + L+ K+ L + LKE + K+ E +D++ + R E K+
Sbjct: 1364 AKIRELETRLEFERTQVKRLESLASRLKENMEKLTEE----RDQRIAAENREKEQNKRLQ 1419
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
L+ + + L+SL + A +S + DL KL K
Sbjct: 1420 RQLRDTKEEMGELARKEAEASRKKHELEMDLESL-EAANQSLQ-------ADL--KLAFK 1469
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKE--MTAKTKLEKEIDEIRSKLSKN 1037
+ + DL+ I + +N L E ++LE +D ++S LSKN
Sbjct: 1470 R-IGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVDGVKSWLSKN 1517
Score = 65.7 bits (153), Expect = 2e-09
Identities = 123/613 (20%), Positives = 242/613 (39%), Gaps = 55/613 (8%)
Query: 1222 LSIELTSEKD--ELQARFIKTES-KFITLEAEMRDLKADYENKITSLE---------STI 1269
L+ ELT E++ E ++ + E+ + + E EM++L+ Y+ +E I
Sbjct: 836 LTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLI 895
Query: 1270 AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE 1329
A +++ + +D KY+ A V+ + R Q++ + +L
Sbjct: 896 RAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNK-RQLERRLG 954
Query: 1330 KTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERK 1389
+A+S ++ + QLK +L + E K + D++L +
Sbjct: 955 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHE 1014
Query: 1390 KLDRMRIAHDKDVKNKD---AELATLKGKLKILEQNSGAGAKRITELKQEYEE---TVKK 1443
+ R ++ +K + KD AE +LK +L+ + + +++ L+ E ++ K
Sbjct: 1015 EAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1074
Query: 1444 LEHSLALEKAEYEELTGKYELLEEE--------HVVTKARLTVEKEQAQGELLHVQKELS 1495
E SLA K + +L K + EEE ++ +A+L +E E + H KE+
Sbjct: 1075 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTH-SKEME 1133
Query: 1496 TALGEI----KTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
+ E+ ++ Q+KL E + Q + ++R G ++N R +
Sbjct: 1134 SRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR--EKRELEGKLATLSDQVNRRDFE 1191
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E+ LR R L + ++
Sbjct: 1192 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAM 1251
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERD----NYKQMLEA 1667
IE + +I KT E Q++ ++ E + N++ + + + +K +
Sbjct: 1252 EVEIEDLH-LQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1310
Query: 1668 AQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLA----- 1722
A + +A+I D A++ ++ +++E + K+ L+ QV LE + + L++
Sbjct: 1311 ASRDLAQI--NDLQAQLEE---ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAK 1365
Query: 1723 -SKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQ 1781
+L T L E++ + RL + SRL E E+L R+A A E +K Q
Sbjct: 1366 IRELETRLEFERTQVK-RLESLASRLKE-NMEKLTEERDQRIA--AENREKEQNKRLQRQ 1421
Query: 1782 QR-LLQETSTLAR 1793
R +E LAR
Sbjct: 1422 LRDTKEEMGELAR 1434
Score = 59.7 bits (138), Expect = 1e-07
Identities = 97/501 (19%), Positives = 207/501 (41%), Gaps = 34/501 (6%)
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETA 694
DL S + A L+K R+ + + L L+ + R+ +L + E +
Sbjct: 955 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLE--GQQVRNHELEKKQ--RRFDSELS 1010
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
++E + ++ +++ ++ EA L++++EE + D ++V L +++ ++
Sbjct: 1011 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDIS- 1069
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
S S A + + E +VK E+E+DE + E+ RL E+ ++
Sbjct: 1070 -SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTH 1128
Query: 815 KTLIKSRSLDASD-QQNVDLK-RQLQV-----IEQEASVLRAK--------TQSLEADNE 859
++SR + + +Q+ K +Q++V E + VLR K T S + +
Sbjct: 1129 SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1188
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLN-TKKTTQLENELKEALAKIKELEMICQDEKSEK 918
++E + + LK K+L +D L L+ K + + E+ + +++E E C +
Sbjct: 1189 DFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1248
Query: 919 K---VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
K V + + D K+K + + + ++ K K
Sbjct: 1249 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDM-NELMKKHKAA 1307
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMY----VVMKNAGLSGKEMTAKTKLEKEIDEIR 1031
+ + DL L+ +E+ E E+ + + M K+ + ++ +IR
Sbjct: 1308 VAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIR 1367
Query: 1032 SKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLT 1091
++ + E T K RL++ ++LK+ KL ++D + +N L Q +
Sbjct: 1368 ELETRLEFERTQVK-RLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1426
Query: 1092 EEM---KNREAQINKLSADLK 1109
EEM +EA+ ++ +L+
Sbjct: 1427 EEMGELARKEAEASRKKHELE 1447
Score = 53.2 bits (122), Expect = 9e-06
Identities = 43/225 (19%), Positives = 106/225 (47%), Gaps = 11/225 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ +++ QI+ + + L ++ R+++EK++I R + + N+ + V +
Sbjct: 1251 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1310
Query: 322 LQQ---KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ ++N+L E+ EK+ L +K++ ++S++E + + + AK+ E
Sbjct: 1311 ASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELE 1370
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
T L E +K+ L L + E++ ++ RE EQ + L +L
Sbjct: 1371 T---RLEFERTQVKR-LESLASRLKENMEKLTEERDQRIAAENREKEQN----KRLQRQL 1422
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVA 483
+ T+ + +L +++AE +K E+ + ++ N+ + + ++A
Sbjct: 1423 RDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLA 1467
Score = 48.4 bits (110), Expect = 3e-04
Identities = 57/290 (19%), Positives = 126/290 (43%), Gaps = 14/290 (4%)
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ- 892
+ Q++ ++E LR+K + E + +L+ + +L+ L S+ + NT ++
Sbjct: 795 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLE--SRISELTSELTDERNTGESASQ 852
Query: 893 -LENELKEALAKIKEL-EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXX 950
L+ E E L KE+ E+ Q + +K++ E E +++ +
Sbjct: 853 LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGE 912
Query: 951 XXXXXXXQAT-LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ K Q+ F+ ++ + K QL++ + DL+ + E ++
Sbjct: 913 WRLKYERAVREVDFTKKRLQQEFEDKLE---VEQQNKRQLERRLGDLQADSEESQRALQQ 969
Query: 1010 AGLSGKEMTAK---TKLEKEIDEIRS-KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
+ +TA+ TKL E ++R+ +L K F +E ++ E + K KL+ +
Sbjct: 970 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1029
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA-DLKNATSL 1114
KD+ + +L+ + T+++ + EA++ +S+ + K+ SL
Sbjct: 1030 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASL 1079
Score = 42.3 bits (95), Expect = 0.017
Identities = 105/554 (18%), Positives = 210/554 (37%), Gaps = 48/554 (8%)
Query: 115 DLGADGSDSNAVTVNLKLPKRRLTGPLPDLDTGQTTNGSQTQLAITKNDSLAERVRKMQL 174
DL AD +S LK +RLT L D TK ++VR +L
Sbjct: 955 DLQADSEESQRALQQLKKKCQRLTAELQD----------------TKLHLEGQQVRNHEL 998
Query: 175 LKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNL 234
K Q F+ E S E +R + + EK R KD + + ++ K+ +
Sbjct: 999 EKKQRRFDSELSQAHEEAQR---EKLQREKLQREKDMLLAEAFSLKQQLEEKDM-DIAGF 1054
Query: 235 KPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEK 294
V V +++ + +++ ++E+D + +E+ K
Sbjct: 1055 TQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK 1114
Query: 295 SDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL 354
+ + T +K R EV + +Q + E +E+ QK+ + EL
Sbjct: 1115 LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1174
Query: 355 ETRPST---EAQTRQIE---QLRAKLLAAETLCEE---LMDENEDMKKELRDLXXXXXXM 405
E + +T + R E +LR L + L + ++D ++ R++ +
Sbjct: 1175 EGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQL 1234
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT--ERKADQLEQEKAEHEKKLLEIV 463
+++ A + E+E + ++ KT E + +L++EK E + +L E
Sbjct: 1235 EESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQ 1294
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ + +++ K + +R LQ +L EAN + L + Q + + +
Sbjct: 1295 EDMNELMKKH--KAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL-QSQVEFLEQ 1351
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
S + + A+ +R+L+ LE E R Q++ E + K+ N +++ D
Sbjct: 1352 SMVDKSLVSRQEAK-IRELETRLEFE---RTQVKRLESLASRLKE-NMEKLTEER---DQ 1403
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
+ + E E QNK + + +E + + + ++ + DL L N
Sbjct: 1404 RIAAENREKE------QNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAAN 1457
Query: 644 HMAANNLRKTAARV 657
+L+ R+
Sbjct: 1458 QSLQADLKLAFKRI 1471
>AF083322-1|AAC32373.1| 994|Homo sapiens centriole associated protein
CEP110 protein.
Length = 994
Score = 74.5 bits (175), Expect = 3e-12
Identities = 176/877 (20%), Positives = 357/877 (40%), Gaps = 97/877 (11%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ + ++E L +D L + + +E E + L R K + E L + ++
Sbjct: 19 RQSEKEMEELHHNIDDLLQEKKSLECEVEE--LHRTVQKRQRQKDFIDGNVESLMTELEI 76
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
+ H+ED+ DE + + + + + SEL EA R + + ++L + + ++
Sbjct: 77 EKSLKHHEDIVDEIECIEKTLLKRRSELR-----EAD-RLLAEAESELSCTKEKTKNAVE 130
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ D K+ L E A+E L R ++T N +L+ + A
Sbjct: 131 KFTDAKRSLLQ------------TESDAEE---LERRAQETAVNLVKADQQLRSLQADAK 175
Query: 447 QLEQEKAEHE---KKLLEIVGGPDG-----MQRENRIKELEQEVARSTEVALRLQ----R 494
LEQ K + E K++ +IV D +++ ++ E Q++ + E+A R + +
Sbjct: 176 DLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ 235
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSL--TRGGSQEDPAQLLRDLQDSLEREADL 552
L E+ L K+ T + ++ + G +++ LL+ ++ +ADL
Sbjct: 236 VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQG--SMVQAKADL 293
Query: 553 REQLRNAEEE-TANCKQVNP-PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+E LR E E T C + + L++ + I E +T I+ ++
Sbjct: 294 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI------- 346
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
KE+ + + + +T+ L L + NH + RV E ++ Q+
Sbjct: 347 -EKEEENLQVVLRQMSKHKTELQNILDMLQLENHELQGLKLQHDQRVSELEKT---QVAV 402
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ K L K IE +K+ E D E +E E+ L+ VE
Sbjct: 403 LEEKLELENLQQISQQQKGEIEW-----QKQLLERDKRE----IERMTAESRALQSCVEC 453
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
L ++KE L+++ K++ + A + ++ +N KL + V+ L+ E+D++
Sbjct: 454 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKME-QSNLEKL-DLNVRKLQQELDQL- 510
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
RD LH ++S Q++ + K ++++ ++ +++ L + +Q+
Sbjct: 511 ------NRDKLSLHNDISAMQQQLQE--KREAVNSLQEELANVQDHLNLAKQDLLHTTKH 562
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
L ++ +LQ K + N + K + ++ L+NE++E K+ + EM+
Sbjct: 563 QDVLLSEQTRLQ---KDISEWAN-RFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMM 618
Query: 911 CQDEKSEKKVRFTEATKKETD--TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
Q + E++ +E +K ET TLK +Q +
Sbjct: 619 FQRLQKERE---SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 675
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAG--------LSGKEMTAK 1020
Q+ + + T TK QL + + L + GE+ + K A L + +T +
Sbjct: 676 QEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTER 735
Query: 1021 TKLEKEIDEI-------RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K EK++ + RS+L KN E E + +Q E+A ++ V +
Sbjct: 736 KKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKEL 795
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
++ E + L Q ++++ R+ +I+ LK+
Sbjct: 796 NQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKS 831
Score = 54.4 bits (125), Expect = 4e-06
Identities = 126/603 (20%), Positives = 254/603 (42%), Gaps = 71/603 (11%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANK------YTTGRSSEVLK 321
E QI K ++ ++++ E+ E+E ++LR+++ T + + LK
Sbjct: 327 ELNVQISERKTQLTLIKQEIEK-EEENLQVVLRQMSKHKTELQNILDMLQLENHELQGLK 385
Query: 322 LQ--QKVNELTTHNEDLRDEK---KHLTQKIREIESELETRPST-EAQTRQIEQLRAKLL 375
LQ Q+V+EL + +EK ++L Q ++ + E+E + E R+IE++ A+
Sbjct: 386 LQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESR 445
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
A ++ E L E ED++++ D+ + R A E +S ++EQ+ N L
Sbjct: 446 ALQSCVECLSKEKEDLQEKC-DI--WEKKLAQTKRVLAAAEENS---KMEQS--NLEKLD 497
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
++K +++ DQL ++K + N I ++Q++ E LQ E
Sbjct: 498 LNVRKLQQELDQLNRDK----------------LSLHNDISAMQQQLQEKREAVNSLQEE 541
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
LA + L+ + + V +S TR Q+D ++ +D + E ++Q
Sbjct: 542 LANVQDHLNLAKQDLLHTTKHQDVLLSEQ--TR--LQKDISEWANRFEDCQKEEETKQQQ 597
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
L+ + E + N + +++M + E E+ + ++ + + KE+
Sbjct: 598 LQVLQNEI----EENKLKLVQQEMMFQRLQ----KERESEESKLETSKV------TLKEQ 643
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
++K + + D + +AA +T E ESL L + +
Sbjct: 644 QH----QLEKELTDQKSKLDQVLSKV---LAAEERVRTLQEEERWCESLEKTLSQTKRQL 696
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
R+ + +L + + D D + L E + E V K E L+ +
Sbjct: 697 SEREQQLVEKSGEL-LALQKEADSMRAD-FSLLRNQFLTERKKAEKQVASLK-EALKIQR 753
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIE 795
L+K + E + S + K A A+ + + +L +E + ++ E E++K++
Sbjct: 754 SQLEKNLLEQKQENSCIQKEMATIELVAQDN-HERARRLMKE-LNQMQYEYTELKKQM-A 810
Query: 796 KERDCERLHAELSLAQKKPKTLIKSR---SLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
++D ER E+S A + K+ +K SL +Q +L L+ I + L + +
Sbjct: 811 NQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELE 870
Query: 853 SLE 855
SL+
Sbjct: 871 SLK 873
Score = 54.0 bits (124), Expect = 5e-06
Identities = 121/592 (20%), Positives = 222/592 (37%), Gaps = 75/592 (12%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQ 1285
L+ EK++LQ + E K L R L A EN +S + D+++++L+ L Q
Sbjct: 454 LSKEKEDLQEKCDIWEKK---LAQTKRVLAAAEENSKME-QSNLEKLDLNVRKLQQELDQ 509
Query: 1286 TTNDKY----DEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
DK D + ++ E R QD LN AK L T E
Sbjct: 510 LNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE 569
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE--------------LDTDLQSE 1387
+L+ D+++ N +N+ +E L + +SE
Sbjct: 570 QTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESE 629
Query: 1388 RKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHS 1447
KL+ ++ + + EL K KL + A +R+ L QE E + LE +
Sbjct: 630 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL-QEEERWCESLEKT 688
Query: 1448 LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
L+ K + E E+ +V K+ GELL +QKE + + L+ +
Sbjct: 689 LSQTKRQLSE--------REQQLVEKS----------GELLALQKEADSMRADFSLLRNQ 730
Query: 1508 LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
+ TE+ + + +ASL+E L +++R++L L ++++E +E
Sbjct: 731 -------FLTERKKAEKQVASLKEAL-----KIQRSQLEKNLLEQKQENSCIQKEMATIE 778
Query: 1568 ----HHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
+H+ +Y + K I + + K
Sbjct: 779 LVAQDNHERARRLMKELNQMQYEYTELKK--------QMANQKDLERRQMEISDAMRTLK 830
Query: 1624 AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKN-GDKSA 1682
+E+ D + + L L + +N + LE+ ++++ N G
Sbjct: 831 SEVKD---EIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEE 887
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDEL-CESRLLASKLNTELVSEKSSAEVRLA 1741
+++ + + D E +R + L +++ ED L + R SK L+ K E L
Sbjct: 888 KLNFSQVHIMD-EHWRGEA--LREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLH 944
Query: 1742 EMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
++ +++ E L++S A A + +L D Q QE + AR
Sbjct: 945 SLRRQVDALGE--LVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR 994
Score = 53.2 bits (122), Expect = 9e-06
Identities = 153/869 (17%), Positives = 355/869 (40%), Gaps = 59/869 (6%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVL 320
S ++E + + E+ +++ + ++ +D LL+ ++ + + + ++
Sbjct: 102 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 161
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST-EAQTRQIEQLRAKLLAAET 379
K Q++ L +DL K + ++EI + + S + +++ E+L +L +
Sbjct: 162 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 221
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
E + + NED L+ L +Q E + + ++ E + + R L K +
Sbjct: 222 DIE-MAERNED--HHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLD-RQLGHKKE 277
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEA 499
+ + Q KA+ ++ L +G + ++ N I+E++ + + L +++E
Sbjct: 278 ELHLLQGSMVQAKADLQEALR--LGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER 335
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
++ T + K + E ++V +++ ++ L+++ D L+ E + L+
Sbjct: 336 KTQLTLIKQEIEK--EEENLQVVLRQMSKHKTE------LQNILDMLQLENHELQGLKLQ 387
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
++ + + L++++ +N+ I + + Q +++ + ++S
Sbjct: 388 HDQRVSELEKTQVAVLEEKLELENLQ--QISQQQKGEIEWQKQLLERDKREIERMTAESR 445
Query: 620 PLS-----IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
L + K E+ Q D I+ A R AA EE+++ L+K+
Sbjct: 446 ALQSCVECLSKEKEDLQEKCD-----IWEKKLAQTKRVLAA-AEENSKMEQSNLEKLDLN 499
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
R + N+ + ND + + E + L E+ A V + L
Sbjct: 500 VRKLQ-QELDQLNRDKLSLHNDISAMQQQLQEKREA--VNSLQEELANVQ----DHLNLA 552
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARR-SLTTNSNKLAEERVKVLEDEIDEVRKKL 793
K+ L K +S T+ + A R + +++++VL++EI+E + KL
Sbjct: 553 KQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKL 612
Query: 794 IEKERDCERLHAELSLAQKKPKT--LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
+++E +RL E + K +T + +++ D K +L + + +
Sbjct: 613 VQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERV 672
Query: 852 QSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK-KTTQLENELKEALAKIKELEMI 910
++L+ + ++ K L K S R + ++ + + Q E + A + + +
Sbjct: 673 RTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFL 732
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ +K+EK+V A+ KE LK ++ AT++ + D +
Sbjct: 733 TERKKAEKQV----ASLKE--ALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHE 786
Query: 971 SFKPRIPKKPTDLTTK-LQLKKMV---EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE 1026
+ R+ K+ + + +LKK + +DLE E+ M+ K+ +T L K
Sbjct: 787 RAR-RLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKD-EIRTSL-KN 843
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+++ +L + L+ E+ LK+ N ++ F K + + +
Sbjct: 844 LNQFLPELPADLEAILERNENLEGELESLKE-NLPFTMNEGPFEEKLNFSQVHIMDEHWR 902
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+ L E++++RE ++L A L++ S Q
Sbjct: 903 GEALREKLRHRE---DRLKAQLRHCMSKQ 928
Score = 50.0 bits (114), Expect = 8e-05
Identities = 100/586 (17%), Positives = 245/586 (41%), Gaps = 38/586 (6%)
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYEN-KITSLESTIAAKDVH-IK 1277
+R ++ S+ +EL+ R +T + + ++R L+AD ++ + ++ K+++ I
Sbjct: 136 KRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIV 195
Query: 1278 QLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSA 1337
+D+ Q + K ++ T E+ +++ L +++ L+ AE
Sbjct: 196 AAKDSDFQCLSKKKEKLTE--ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK 253
Query: 1338 AKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIA 1397
K ++ + ++A L+ S + KA +L L+ ++ +
Sbjct: 254 LKSQVTSQQQEMAVLDR--QLGHKKEELHLLQGSMVQAKA-DLQEALRLGETEVTE-KCN 309
Query: 1398 HDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEE 1457
H ++VK+ EL+ KG+L + ++T +KQE E+ + L+ L E
Sbjct: 310 HIREVKSLLEELSFQKGELNV---QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTE 366
Query: 1458 LTGKYELLEEEHVVTKARLTVEKEQAQG-ELLHVQKELSTALGEIKTLQEKLGTESAAWN 1516
L ++L+ +E + QG +L H Q+ ++ L+EKL E+
Sbjct: 367 LQNILDMLQ-----------LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQI 415
Query: 1517 TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXX 1576
++ + + I ++ L E+ER +R Q E + ++ L+ D
Sbjct: 416 SQ--QQKGEIEWQKQLLERDKREIERMTAESRALQSCVE--CLSKEKEDLQEKCDIWEKK 471
Query: 1577 XXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQ 1636
E SK+++ + + + + +I+ + + + +
Sbjct: 472 LAQTKRVLAAAEENSKMEQSNLEKLDLNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK 531
Query: 1637 ---MNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTD 1693
+N++++EL ++ + ++ +++ + + + ++ D S +R +
Sbjct: 532 REAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQK-DISEWANRFEDCQKE 590
Query: 1694 EEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
EE + ++ +L+ ++ + +L + ++ +L E SE+S E ++ + ++ E+E
Sbjct: 591 EETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKE 650
Query: 1754 RLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
L+ ++++ + +++ A +E+ R LQE L +TL
Sbjct: 651 --LTDQKSKLDQVLSKVLAA-----EERVRTLQEEERWCESLEKTL 689
Score = 35.5 bits (78), Expect = 2.0
Identities = 35/174 (20%), Positives = 85/174 (48%), Gaps = 13/174 (7%)
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP-------KTLIKSRSL 823
S + +E+ ++ L ID++ ++ E + E LH + Q++ ++L+ +
Sbjct: 17 SKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQRQKDFIDGNVESLMTELEI 76
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKAL 883
+ S + + D+ +++ IE+ ++L+ +++ EAD + E+ +L K +K
Sbjct: 77 EKSLKHHEDIVDEIECIEK--TLLKRRSELREADRLLAEAES-ELSCTKEKTKNAVEKFT 133
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
D + Q E++ +E + +E + K+++++R +A K+ + K KQ
Sbjct: 134 DAK-RSLLQTESDAEELERRAQETAV--NLVKADQQLRSLQADAKDLEQHKIKQ 184
Score = 35.1 bits (77), Expect = 2.6
Identities = 44/222 (19%), Positives = 89/222 (40%), Gaps = 5/222 (2%)
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
DE+ + L K +E A +A+ +S+L+ + E+ A+
Sbjct: 88 DEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAE 147
Query: 1379 ELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYE 1438
EL+ Q L + D+ +++ A+ L+ + KI ++ +I K
Sbjct: 148 ELERRAQETAVNL----VKADQQLRSLQADAKDLE-QHKIKQEEILKEINKIVAAKDSDF 202
Query: 1439 ETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
+ + K + L E + ++ E E+ H+ V + + EL ++ ++++
Sbjct: 203 QCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQ 262
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEV 1540
E+ L +LG + + + M + A LQE L G EV
Sbjct: 263 QEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEV 304
>AB177860-1|BAD66838.1| 1715|Homo sapiens KIAA0216 splice variant 2
protein.
Length = 1715
Score = 74.5 bits (175), Expect = 3e-12
Identities = 151/769 (19%), Positives = 313/769 (40%), Gaps = 66/769 (8%)
Query: 299 LRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETR 357
+R L + + + + E+ +L+ K+ + +LR L +I E+ SEL + R
Sbjct: 919 VRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 978
Query: 358 PSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDL------XXXXXXMQDNFRE 411
+ E+ ++ ++ A+ L AE +EL + + +KK++ + + N
Sbjct: 979 NTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEV 1038
Query: 412 DQADEYSSLRRELEQTIKNCRVLSFKLKKT-ERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
D D R + E+ ++ +L++ E K + +Q K + E++L ++ D +
Sbjct: 1039 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQA--DSEE 1096
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGG 530
+ +++L+++ RL EL + G +V E K R +
Sbjct: 1097 SQRALQQLKKK-------CQRLTAELQDTKLHLEG-----QQVRNHELEKKQRRFDSELS 1144
Query: 531 SQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
+ AQ + ++ L+RE D+ + ++ K ++ F K V + + DI
Sbjct: 1145 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ-DIS 1203
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTT----EETQFHFDLPYLSIFNHMA 646
E+ + K+ +K K L T E+ + ++ +
Sbjct: 1204 SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEME-MERMRQTH 1262
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSR---KLSPTPPANKLSIETANDNDEKETD 703
+ + VEE +S +LK+M + K +L + A +D+
Sbjct: 1263 SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1322
Query: 704 EADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+ + +E +L +L +A + + ++ L+ + K+++ +L +++ T A +
Sbjct: 1323 DFE-SEKRLRKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAA-V 1379
Query: 762 TARRSLTTNSNKL---AEERVK---VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK 815
AR+++ L ++ K LE+++ ++++ E + E +++ KK K
Sbjct: 1380 KARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHK 1439
Query: 816 TLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKN 873
+ S D + Q DL+ QL+ +E L+ K Q+L++ E L+ +K L +
Sbjct: 1440 AAVAQASRDLA--QINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQE 1497
Query: 874 AKSLRSDKALDL---NTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
AK + L+ K+ L + LKE + K+ E +D++ + R E K+
Sbjct: 1498 AKIRELETRLEFERTQVKRLESLASRLKENMEKLTEE----RDQRIAAENREKEQNKRLQ 1553
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
L+ + + L+SL + A +S + DL KL K
Sbjct: 1554 RQLRDTKEEMGELARKEAEASRKKHELEMDLESL-EAANQSLQ-------ADL--KLAFK 1603
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKE--MTAKTKLEKEIDEIRSKLSKN 1037
+ + DL+ I + +N L E ++LE +D ++S LSKN
Sbjct: 1604 R-IGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVDGVKSWLSKN 1651
Score = 65.7 bits (153), Expect = 2e-09
Identities = 123/613 (20%), Positives = 242/613 (39%), Gaps = 55/613 (8%)
Query: 1222 LSIELTSEKD--ELQARFIKTES-KFITLEAEMRDLKADYENKITSLE---------STI 1269
L+ ELT E++ E ++ + E+ + + E EM++L+ Y+ +E I
Sbjct: 970 LTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLI 1029
Query: 1270 AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE 1329
A +++ + +D KY+ A V+ + R Q++ + +L
Sbjct: 1030 RAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNK-RQLERRLG 1088
Query: 1330 KTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERK 1389
+A+S ++ + QLK +L + E K + D++L +
Sbjct: 1089 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHE 1148
Query: 1390 KLDRMRIAHDKDVKNKD---AELATLKGKLKILEQNSGAGAKRITELKQEYEE---TVKK 1443
+ R ++ +K + KD AE +LK +L+ + + +++ L+ E ++ K
Sbjct: 1149 EAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1208
Query: 1444 LEHSLALEKAEYEELTGKYELLEEE--------HVVTKARLTVEKEQAQGELLHVQKELS 1495
E SLA K + +L K + EEE ++ +A+L +E E + H KE+
Sbjct: 1209 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTH-SKEME 1267
Query: 1496 TALGEI----KTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
+ E+ ++ Q+KL E + Q + ++R G ++N R +
Sbjct: 1268 SRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR--EKRELEGKLATLSDQVNRRDFE 1325
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E+ LR R L + ++
Sbjct: 1326 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAM 1385
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERD----NYKQMLEA 1667
IE + +I KT E Q++ ++ E + N++ + + + +K +
Sbjct: 1386 EVEIEDLH-LQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1444
Query: 1668 AQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLA----- 1722
A + +A+I D A++ ++ +++E + K+ L+ QV LE + + L++
Sbjct: 1445 ASRDLAQI--NDLQAQLEE---ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAK 1499
Query: 1723 -SKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQ 1781
+L T L E++ + RL + SRL E E+L R+A A E +K Q
Sbjct: 1500 IRELETRLEFERTQVK-RLESLASRLKE-NMEKLTEERDQRIA--AENREKEQNKRLQRQ 1555
Query: 1782 QR-LLQETSTLAR 1793
R +E LAR
Sbjct: 1556 LRDTKEEMGELAR 1568
Score = 59.7 bits (138), Expect = 1e-07
Identities = 97/501 (19%), Positives = 207/501 (41%), Gaps = 34/501 (6%)
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETA 694
DL S + A L+K R+ + + L L+ + R+ +L + E +
Sbjct: 1089 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLE--GQQVRNHELEKKQ--RRFDSELS 1144
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
++E + ++ +++ ++ EA L++++EE + D ++V L +++ ++
Sbjct: 1145 QAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDIS- 1203
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
S S A + + E +VK E+E+DE + E+ RL E+ ++
Sbjct: 1204 -SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTH 1262
Query: 815 KTLIKSRSLDASD-QQNVDLK-RQLQV-----IEQEASVLRAK--------TQSLEADNE 859
++SR + + +Q+ K +Q++V E + VLR K T S + +
Sbjct: 1263 SKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1322
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLN-TKKTTQLENELKEALAKIKELEMICQDEKSEK 918
++E + + LK K+L +D L L+ K + + E+ + +++E E C +
Sbjct: 1323 DFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1382
Query: 919 K---VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
K V + + D K+K + + + ++ K K
Sbjct: 1383 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDM-NELMKKHKAA 1441
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMY----VVMKNAGLSGKEMTAKTKLEKEIDEIR 1031
+ + DL L+ +E+ E E+ + + M K+ + ++ +IR
Sbjct: 1442 VAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIR 1501
Query: 1032 SKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLT 1091
++ + E T K RL++ ++LK+ KL ++D + +N L Q +
Sbjct: 1502 ELETRLEFERTQVK-RLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1560
Query: 1092 EEM---KNREAQINKLSADLK 1109
EEM +EA+ ++ +L+
Sbjct: 1561 EEMGELARKEAEASRKKHELE 1581
Score = 53.2 bits (122), Expect = 9e-06
Identities = 43/225 (19%), Positives = 106/225 (47%), Gaps = 11/225 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ +++ QI+ + + L ++ R+++EK++I R + + N+ + V +
Sbjct: 1385 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1444
Query: 322 LQQ---KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+ ++N+L E+ EK+ L +K++ ++S++E + + + AK+ E
Sbjct: 1445 ASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELE 1504
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
T L E +K+ L L + E++ ++ RE EQ + L +L
Sbjct: 1505 T---RLEFERTQVKR-LESLASRLKENMEKLTEERDQRIAAENREKEQN----KRLQRQL 1556
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVA 483
+ T+ + +L +++AE +K E+ + ++ N+ + + ++A
Sbjct: 1557 RDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLA 1601
Score = 48.4 bits (110), Expect = 3e-04
Identities = 57/290 (19%), Positives = 126/290 (43%), Gaps = 14/290 (4%)
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ- 892
+ Q++ ++E LR+K + E + +L+ + +L+ L S+ + NT ++
Sbjct: 929 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLE--SRISELTSELTDERNTGESASQ 986
Query: 893 -LENELKEALAKIKEL-EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXX 950
L+ E E L KE+ E+ Q + +K++ E E +++ +
Sbjct: 987 LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGE 1046
Query: 951 XXXXXXXQAT-LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ K Q+ F+ ++ + K QL++ + DL+ + E ++
Sbjct: 1047 WRLKYERAVREVDFTKKRLQQEFEDKLE---VEQQNKRQLERRLGDLQADSEESQRALQQ 1103
Query: 1010 AGLSGKEMTAK---TKLEKEIDEIRS-KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
+ +TA+ TKL E ++R+ +L K F +E ++ E + K KL+ +
Sbjct: 1104 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1163
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA-DLKNATSL 1114
KD+ + +L+ + T+++ + EA++ +S+ + K+ SL
Sbjct: 1164 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASL 1213
Score = 42.3 bits (95), Expect = 0.017
Identities = 105/554 (18%), Positives = 210/554 (37%), Gaps = 48/554 (8%)
Query: 115 DLGADGSDSNAVTVNLKLPKRRLTGPLPDLDTGQTTNGSQTQLAITKNDSLAERVRKMQL 174
DL AD +S LK +RLT L D TK ++VR +L
Sbjct: 1089 DLQADSEESQRALQQLKKKCQRLTAELQD----------------TKLHLEGQQVRNHEL 1132
Query: 175 LKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNL 234
K Q F+ E S E +R + + EK R KD + + ++ K+ +
Sbjct: 1133 EKKQRRFDSELSQAHEEAQR---EKLQREKLQREKDMLLAEAFSLKQQLEEKDM-DIAGF 1188
Query: 235 KPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEK 294
V V +++ + +++ ++E+D + +E+ K
Sbjct: 1189 TQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK 1248
Query: 295 SDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL 354
+ + T +K R EV + +Q + E +E+ QK+ + EL
Sbjct: 1249 LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKREL 1308
Query: 355 ETRPST---EAQTRQIE---QLRAKLLAAETLCEE---LMDENEDMKKELRDLXXXXXXM 405
E + +T + R E +LR L + L + ++D ++ R++ +
Sbjct: 1309 EGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQL 1368
Query: 406 QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT--ERKADQLEQEKAEHEKKLLEIV 463
+++ A + E+E + ++ KT E + +L++EK E + +L E
Sbjct: 1369 EESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQ 1428
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ + +++ K + +R LQ +L EAN + L + Q + + +
Sbjct: 1429 EDMNELMKKH--KAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL-QSQVEFLEQ 1485
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
S + + A+ +R+L+ LE E R Q++ E + K+ N +++ D
Sbjct: 1486 SMVDKSLVSRQEAK-IRELETRLEFE---RTQVKRLESLASRLKE-NMEKLTEER---DQ 1537
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
+ + E E QNK + + +E + + + ++ + DL L N
Sbjct: 1538 RIAAENREKE------QNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAAN 1591
Query: 644 HMAANNLRKTAARV 657
+L+ R+
Sbjct: 1592 QSLQADLKLAFKRI 1605
>BC127760-1|AAI27761.1| 658|Homo sapiens Unknown (protein for
IMAGE:40127781) protein.
Length = 658
Score = 72.9 bits (171), Expect = 1e-11
Identities = 82/402 (20%), Positives = 165/402 (41%), Gaps = 24/402 (5%)
Query: 522 SRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMT 581
+ S + GG Q + L+ + +++E++ EE K + M
Sbjct: 33 AEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMR 92
Query: 582 DNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET-----QFHFDL 636
D D + + + + ++ + K++ L +T E DL
Sbjct: 93 DTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDL 152
Query: 637 PY---LSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIET 693
+S+ H N+ + E++NE L QL ++ A+ + +LS++
Sbjct: 153 KVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEI-AKQALQNELEKMKELSLKR 211
Query: 694 ANDND----EKETD----EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKEL 745
D EK+ E D ++K L+ ++EA ++R+K+ +++++K+ + ++++
Sbjct: 212 RGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKY 271
Query: 746 TSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHA 805
S + S KL R++ +E+E + + +K++E E + L A
Sbjct: 272 RSFYGDLDSPLPKGEAGGPPSTREAELKL---RLRPVEEEANILGRKIVELEVENRGLKA 328
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
EL + + + + +L++ LQ++E E +LR LE N+++ E
Sbjct: 329 ELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAEL 388
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
K + KS D A + KT L+ ELK A +I EL
Sbjct: 389 NKYKY----KSGGHDSARHHDNAKTEALQEELKAARLQINEL 426
Score = 72.9 bits (171), Expect = 1e-11
Identities = 61/197 (30%), Positives = 95/197 (48%), Gaps = 30/197 (15%)
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+L +ENE +K E+ +L M+D F E+ A + +R ELE+ KNCR+L ++L+K
Sbjct: 68 EKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKA 127
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANS 501
ERK + Q G DG ++ LEQ++ + +V++RL EL
Sbjct: 128 ERKRLRYAQ------------TGEIDG----ELLRSLEQDLKVAKDVSVRLHHELENVEE 171
Query: 502 KFTGS-------NPSLMKVP------QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
K T + L++V Q E K+ SL R GS++ P + Q E
Sbjct: 172 KRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEE 231
Query: 549 E-ADLREQLRNAEEETA 564
+ DL+ QL+ +EE A
Sbjct: 232 DNEDLKCQLQFVKEEAA 248
Score = 65.7 bits (153), Expect = 2e-09
Identities = 92/427 (21%), Positives = 175/427 (40%), Gaps = 41/427 (9%)
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR-ELAEANSKFTGSN 507
EQE+ + E + L + +N I EL E+ + +L E + +N
Sbjct: 59 EQEEMQEEMEKLR----EENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 114
Query: 508 PSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD----LREQLRNAEEET 563
+ ++ Q K R L + E +LLR L+ L+ D L +L N EE+
Sbjct: 115 KNC-RILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKR 173
Query: 564 ANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
+ N L +Q++ I + + K + P S++K+ P
Sbjct: 174 TTTEDENEK--LRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEE 231
Query: 624 DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPT 683
D + Q F ++ +RK A+++++ + +L+K + SP
Sbjct: 232 DNEDLKCQLQFVKEEAAL--------MRKKMAKIDKEKDRFEHELQKYRSFYGDLD-SPL 282
Query: 684 PPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVK 743
P E +E AE+KL L E+EA +L RK+ ELE + LK ++
Sbjct: 283 PKG-----EAGGPPSTRE------AELKLRLRPVEEEANILGRKIVELEVENRGLKAELD 331
Query: 744 ELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERL 803
+L + GS R + + ++L + ++++EDE + +R+ + + E +R+
Sbjct: 332 DLRGDDFN------GSANPLMREQSESLSEL-RQHLQLVEDETELLRRNVADLEEQNKRI 384
Query: 804 HAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQT 863
AEL+ + K +R D + + L+ +L+ + + L K L+ +N L +
Sbjct: 385 TAELNKYKYKSGGHDSARHHD--NAKTEALQEELKAARLQINELSGKVMQLQYENRVLMS 442
Query: 864 ENKKLQL 870
++ L
Sbjct: 443 NMQRYDL 449
Score = 52.0 bits (119), Expect = 2e-05
Identities = 83/405 (20%), Positives = 174/405 (42%), Gaps = 27/405 (6%)
Query: 705 ADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
A P+ +L EQE ++ ++E+L ++ E LK ++ EL +++ + T +
Sbjct: 46 APPSSQPHPQQLQEQEE--MQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQL 103
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
+ + + A + ++L+ + + +K + + E + EL + ++ + K S+
Sbjct: 104 QEMRHELER-ANKNCRILQYRLRKAERKRLRYAQTGE-IDGELLRSLEQDLKVAKDVSVR 161
Query: 825 ASDQ-QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKAL 883
+ +NV+ KR E E LR + +E + LQ E +K++ L + R K L
Sbjct: 162 LHHELENVEEKRT--TTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKR--RGSKDL 217
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ KK Q E K +L+ + ++E + + + + K++ Q
Sbjct: 218 PKSEKKAQQTPTEEDNEDLKC-QLQFV-KEEAALMRKKMAKIDKEKDRFEHELQKYRSFY 275
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
+ + + K R+ +P + + +K+VE LE E +
Sbjct: 276 GDLDSPLPKGEAGGPPSTR------EAELKLRL--RPVEEEANILGRKIVE-LEVENRGL 326
Query: 1004 YVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
+ + L G + L +E E S+L ++ +E L+ +A L++ N ++
Sbjct: 327 KAELDD--LRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRI 384
Query: 1063 EGDKDVFANKYKALENENSNLSNQCKT--LTEEMKNREAQINKLS 1105
+ + + KYK+ ++++ + KT L EE+K QIN+LS
Sbjct: 385 TAELNKY--KYKSGGHDSARHHDNAKTEALQEELKAARLQINELS 427
Score = 37.5 bits (83), Expect = 0.48
Identities = 71/318 (22%), Positives = 135/318 (42%), Gaps = 29/318 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEK---EKSDILLRRLAN-IDTANKYTTGRSS 317
+ +++ +++ E LK E+D LR + + E+ L+ + + ++ ANK
Sbjct: 63 MQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQY 122
Query: 318 EVLKLQQK------VNE-----LTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ 366
+ K ++K E L + +DL+ K + E+E+ E R +TE +
Sbjct: 123 RLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDEN-- 180
Query: 367 IEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ 426
E+LR +L+ E + L +E E M KEL + + ++ Q +L+
Sbjct: 181 -EKLRQQLIEVEIAKQALQNELEKM-KELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 238
Query: 427 TIKNCRVLSFKLKKTERKADQLEQEKAEHE-KKLLEIVGGPDGMQRENRIKELEQEVARS 485
++ + + ++K K D+ E+++ EHE +K G D + R
Sbjct: 239 QLQFVKEEAALMRKKMAKIDK-EKDRFEHELQKYRSFYGDLDSPLPKGEAG--GPPSTRE 295
Query: 486 TEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
E+ LRL+ EAN G ++V + +K L L+R+ +S
Sbjct: 296 AELKLRLRPVEEEAN--ILGRKIVELEV-ENRGLKAELDDLRGDDFNGSANPLMREQSES 352
Query: 546 LEREADLREQLRNAEEET 563
L ++LR+ L+ E+ET
Sbjct: 353 L---SELRQHLQLVEDET 367
>AF273047-1|AAG34907.1| 623|Homo sapiens CTCL tumor antigen se20-7
protein.
Length = 623
Score = 72.9 bits (171), Expect = 1e-11
Identities = 121/601 (20%), Positives = 262/601 (43%), Gaps = 53/601 (8%)
Query: 351 ESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR 410
E++ + + E + +I QLR+++ T EEL ++ E K E + +
Sbjct: 31 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE--KSERAAFEELEKALSTAQK 88
Query: 411 EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
++A L+ E+++ IK K +E + L+QE + ++++++++ Q
Sbjct: 89 TEEARR--KLKAEMDEQIKTIE------KTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 140
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGG 530
K E+E+AR + L ++L +F ++ Q E +K+S+
Sbjct: 141 IAKLQKLHEKELARKEQ---ELTKKLQTREREFQEQMKVALEKSQSEYLKISQE------ 191
Query: 531 SQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
++ + L +L+ L+++A L E +E + + +Q T+ + + ++ + +
Sbjct: 192 KEQQESLALEELE--LQKKAILTE----SENKLRDLQQ-EAETYRTRILELESSLEKSLQ 244
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFD----LPYLSIFNHMA 646
E++ N ++ +H + + + + KT E+ H L +
Sbjct: 245 ENK---NQSKDLAVHLEAEKNKHNMEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQY 301
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSI-ETANDNDEKETDEA 705
+ K + E++ E+LL K++ +A +++ KL + +T ++ E E
Sbjct: 302 QTEMEKLREKCEQEKETLLKD-KEIIFQAHIEEMN-EKTLEKLDVKQTELESLSSELSEV 359
Query: 706 DPAEMKLLLELNEQEATVLRRKVEELEQDKEA-LKKQVKELTSKISSVTKTSAGSNTTAR 764
A KL E+E +VL+ + ++++Q+ EA + +Q ++ S+ K S
Sbjct: 360 LKARHKL-----EEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE 414
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS-- 822
++L N+L E +K + + E + + E D +R EL A K +S
Sbjct: 415 KALKDQINQL-ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT 473
Query: 823 ---LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKNAKSL 877
A ++Q L+++L +E E +L + +EA + + TE K+Q+ + L
Sbjct: 474 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 533
Query: 878 -RSDKALDLNTKKTTQL-ENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
+ + ++ K TQ+ E++L++ + ++ + I EK ++ E KKE + L
Sbjct: 534 EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV-EKENMILQMREGQKKEIEILTQ 592
Query: 936 K 936
K
Sbjct: 593 K 593
Score = 67.7 bits (158), Expect = 4e-10
Identities = 116/596 (19%), Positives = 256/596 (42%), Gaps = 51/596 (8%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEK-KHLTQKIREIESELETRPSTEAQTRQIE-QLRA 372
+ E+ +L+ ++ ++TT E+LR++K K E+E L T TE R+++ ++
Sbjct: 43 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 102
Query: 373 KLLAAETLCEE----LMDENEDMKKELRDLXXXX-----XXMQDNFREDQADEYSSLRRE 423
++ E EE L E +K+E+ D+ +Q ++ A + L ++
Sbjct: 103 QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK 162
Query: 424 LEQTIKNCR-VLSFKLKKTERKADQLEQEKAEHEK---KLLEIVGGPDGMQRENRIKELE 479
L+ + + + L+K++ + ++ QEK + E + LE+ + EN++++L+
Sbjct: 163 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 222
Query: 480 QEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL 539
QE L L+ L ++ + + L + E K + + + L
Sbjct: 223 QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNMEITVMVEKHKTELESL 282
Query: 540 RDLQDSL--EREADLREQLRNAEEE-TANCKQVNPPTFLDKQVM---------TDNIVTC 587
+ QD+L E+ L++Q + E+ C+Q DK+++ +
Sbjct: 283 KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 342
Query: 588 DIH--ESETVTNSIQN--KMIHAASTPSS--KEKSDSPPLSIDKTTEETQFHFDLPYLSI 641
D+ E E++++ + K H S K+++D ++ +E + H SI
Sbjct: 343 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 402
Query: 642 FNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKE 701
+ R A ++ N+ LL K R + L ++ +E + ++
Sbjct: 403 IKEHEVSIQRTEKALKDQINQLELL------LKERDKHLK----EHQAHVENLEADIKRS 452
Query: 702 TDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
E A KL + + Q AT + + E+ L++++ +L ++ +TK A
Sbjct: 453 EGELQQASAKLDVFQSYQSAT--HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEA 510
Query: 762 TARRSLT-TNSNKL-AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK 819
+ T +++K+ ++ ++ LE + E+ +K+ + E + + Q++ K ++
Sbjct: 511 QKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV 570
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAK 875
+ + Q K++++++ Q+ L AK S+ NE+ +T+ KK + K K
Sbjct: 571 EKE-NMILQMREGQKKEIEILTQK---LSAKEDSIHILNEEYETKFKKKKKKKKKK 622
Score = 64.1 bits (149), Expect = 5e-09
Identities = 75/384 (19%), Positives = 170/384 (44%), Gaps = 18/384 (4%)
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
+E+LEQDK + + K + + + + + +TT +L E++ K +
Sbjct: 18 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFE 77
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
E+ K L ++ E + ++ KT+ K+ S+++ + L+++L ++QE V+
Sbjct: 78 ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT-----SEEERISLQQELSRVKQE--VV 130
Query: 848 RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK-E 906
+S E KLQ ++K +L + + L L T++ + + ++K AL K + E
Sbjct: 131 DVMKKSSEEQIAKLQKLHEK-ELARKEQELTK----KLQTRE-REFQEQMKVALEKSQSE 184
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL-KSLK 965
I Q+++ ++ + E ++ L + +++L KSL+
Sbjct: 185 YLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQ 244
Query: 966 DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
++ +S + + +++ MVE + E+ E ++A + K K + +
Sbjct: 245 ENKNQSKDLAVHLEAEKNKHNMEITVMVEKHKTEL-ESLKHQQDALWTEKLQVLKQQYQT 303
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
E++++R K + +K + A ++++N K DV + ++L +E S +
Sbjct: 304 EMEKLREKCEQEKETLLKDKEIIFQ--AHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 361
Query: 1086 QCKTLTEEMKNREAQINKLSADLK 1109
L EE+ + Q +K+ +L+
Sbjct: 362 ARHKLEEELSVLKDQTDKMKQELE 385
Score = 62.9 bits (146), Expect = 1e-08
Identities = 89/413 (21%), Positives = 192/413 (46%), Gaps = 39/413 (9%)
Query: 715 ELNEQEATVLRRKVEELEQ-------DKEALKKQVKELTSKISSVTKTSAGSNTTARRSL 767
EL EQ+ R EELE+ +EA +K E+ +I ++ KTS + ++ L
Sbjct: 63 ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQEL 122
Query: 768 TTNSNKLAEERVKVLEDEIDEVRKKLIEKE--RDCERLHAELSLAQKKPKTLIKSRSLDA 825
+ ++ + K E++I +++K L EKE R + L +L +++ + +K +L+
Sbjct: 123 SRVKQEVVDVMKKSSEEQIAKLQK-LHEKELARKEQELTKKLQTREREFQEQMKV-ALEK 180
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKNAKSLRSDKAL 883
S + + + ++ + +QE+ L + LE + + TE NK L + A++ R+ + L
Sbjct: 181 SQSEYLKISQEKE--QQESLAL----EELELQKKAILTESENKLRDLQQEAETYRT-RIL 233
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT---EATKKETDTLKSKQXXX 940
+L + LE L+E + K+L + + EK++ + T E K E ++LK +Q
Sbjct: 234 ELESS----LEKSLQENKNQSKDLAVHLEAEKNKHNMEITVMVEKHKTELESLKHQQDAL 289
Query: 941 XXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL--KKMVEDLEC 998
Q ++ L++ ++ + + K ++ +K +E L+
Sbjct: 290 WTEKLQVLKQQY-----QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDV 344
Query: 999 EIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDV 1058
+ E+ + ++ LS + + A+ KLE+E+ ++ + K E + + + + V
Sbjct: 345 KQTELESL--SSELS-EVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH--HQQQV 399
Query: 1059 NAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
++ ++ + KAL+++ + L K + +K +A + L AD+K +
Sbjct: 400 DSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRS 452
Score = 53.6 bits (123), Expect = 7e-06
Identities = 77/322 (23%), Positives = 139/322 (43%), Gaps = 25/322 (7%)
Query: 154 QTQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEK-ERERRSLSKSKEDEKTARYKD-- 210
+T+L K+ A K+Q+LK Q E E EK E+E+ +L K KE A ++
Sbjct: 276 KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 335
Query: 211 ERSSTKDDVNFL-MQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEY 269
E++ K DV ++ +S S LK + +D +
Sbjct: 336 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 395
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q Q++ + +E ++ +R E+ K++ I+ R + + Q V L
Sbjct: 396 QQQVDSIIKEHEVSIQRTEKALKDQ----------INQLELLLKERDKHLKEHQAHVENL 445
Query: 330 TTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQLRAKLLAAET---LCEELM 385
+ E + + K+ +S + T T+A Q+ QL+ KLL ET L + +
Sbjct: 446 EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 505
Query: 386 DENEDMKKEL-RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN-CRVLSFKLKKTER 443
E E KK++ +L +QD + Q ++ +S E+EQ +K+ +V KL+ +
Sbjct: 506 AEVEAQKKDVCTELDAHKIQVQDLMQ--QLEKQNS---EMEQKVKSLTQVYESKLEDGNK 560
Query: 444 KADQLEQEKAEHEKKLLEIVGG 465
+ +Q +Q E E +L++ G
Sbjct: 561 EQEQTKQILVEKENMILQMREG 582
Score = 51.6 bits (118), Expect = 3e-05
Identities = 110/607 (18%), Positives = 234/607 (38%), Gaps = 76/607 (12%)
Query: 547 EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHA 606
E + + E L EEE A + + + + + E + ++
Sbjct: 31 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTE 90
Query: 607 ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTA----ARVEEDNE 662
+ K + D +I+KT+EE + LS + ++K++ A++++ +E
Sbjct: 91 EARRKLKAEMDEQIKTIEKTSEEERISLQQE-LSRVKQEVVDVMKKSSEEQIAKLQKLHE 149
Query: 663 SLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT 722
L + ++ TK + K+++E + K + E + E L EL Q+
Sbjct: 150 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 209
Query: 723 VL---RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT------------------ 761
+L K+ +L+Q+ E + ++ EL S + + + +
Sbjct: 210 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNMEIT 269
Query: 762 -------TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEK-ERDCERLHAELSLA--- 810
T SL + L E+++VL+ + +KL EK E++ E L + +
Sbjct: 270 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 329
Query: 811 ---QKKPKTL----IKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQT 863
+ KTL +K L++ + ++ + +E+E SVL+ +T ++ + E
Sbjct: 330 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE---- 385
Query: 864 ENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT 923
K+ KN + D + + + E LK+ +I +LE++ ++ K
Sbjct: 386 --AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD---QINQLELLLKERDKHLKEHQA 440
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
E D +S+ + T A + ++ +K DL
Sbjct: 441 HVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT------KAYEEQLAQLQQKLLDL 494
Query: 984 -TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK-EIDEIRSKLSKNDSEF 1041
T ++ L K V ++E + K++ + K ++ ++ +L K +SE
Sbjct: 495 ETERILLTKQVAEVEAQ--------------KKDVCTELDAHKIQVQDLMQQLEKQNSEM 540
Query: 1042 TNE-KNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
+ K+ Q +KL+D N + E K + K + + + LT+++ +E
Sbjct: 541 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 600
Query: 1101 INKLSAD 1107
I+ L+ +
Sbjct: 601 IHILNEE 607
Score = 46.0 bits (104), Expect = 0.001
Identities = 120/604 (19%), Positives = 253/604 (41%), Gaps = 64/604 (10%)
Query: 1211 QAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA 1270
+ +V+A T R++ L +++E+ +++ K +T + E +L+ E +S A
Sbjct: 25 KGMVIAETKRQMHETLEMKEEEIAQ--LRSRIKQMTTQGE--ELREQKE------KSERA 74
Query: 1271 AKDVHIKQLEDALRQTTNDKYDEATSPV--EMVE-MRXXXXXXXXXXXXXQDELNNAK-- 1325
A ++LE AL +T K +EA + EM E ++ Q EL+ K
Sbjct: 75 A----FEELEKAL--STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE 128
Query: 1326 -IKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL 1384
+ + K +E AKL+ K +LA+ E + + + L
Sbjct: 129 VVDVMKKSSEEQIAKLQKLHEK-ELARKEQELTKKLQTREREFQEQMKVALEKSQSEY-L 186
Query: 1385 QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKL 1444
+ ++K + +A ++ K A L + KL+ L+Q + RI EL+ L
Sbjct: 187 KISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELE-------SSL 239
Query: 1445 EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGE-LLHVQKELSTALGEIKT 1503
E SL K + ++L E + +H + + + VEK + + E L H Q L T +++
Sbjct: 240 EKSLQENKNQSKDLAVHLEAEKNKHNM-EITVMVEKHKTELESLKHQQDALWTE--KLQV 296
Query: 1504 LQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA-ANDR 1562
L+++ TE + + + ++ +E + E + +LD ++ EL + +++
Sbjct: 297 LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL 356
Query: 1563 RDVLEHHHD-XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKA 1621
+VL+ H E +K+ I+++EKA
Sbjct: 357 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKA 416
Query: 1622 RKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEA-AQKSMAEIKNGDK 1680
K +I ++L+ L + + +E + + LEA ++S E++
Sbjct: 417 LKDQI---------------NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA 461
Query: 1681 SARIHRNSISSTDEE--EYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEK----S 1734
+ ++ S+T E+ Y ++A L+Q++ LE E R+L +K E+ ++K +
Sbjct: 462 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE----RILLTKQVAEVEAQKKDVCT 517
Query: 1735 SAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA-WHKERDEQQRLLQETSTLAR 1793
+ ++Q + + E++ + + +L +KE+++ +++L E +
Sbjct: 518 ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMIL 577
Query: 1794 DLRQ 1797
+R+
Sbjct: 578 QMRE 581
Score = 42.3 bits (95), Expect = 0.017
Identities = 41/182 (22%), Positives = 87/182 (47%), Gaps = 17/182 (9%)
Query: 1615 IEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAE 1674
IEQ E+ + I +TK + + +E+ L +++ + + + ++ E +++ A
Sbjct: 18 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER--AA 75
Query: 1675 IKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLL----ASKLNTELV 1730
+ +K+ S + EE R A +++Q+ +E E R+ S++ E+V
Sbjct: 76 FEELEKAL-----STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV 130
Query: 1731 S-EKSSAEVRLAEMQSRLNEYE----EERLLSSGRARVAGLATRMELAWHKERDEQQRLL 1785
K S+E ++A++Q +L+E E E+ L + R +M++A K + E ++
Sbjct: 131 DVMKKSSEEQIAKLQ-KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 189
Query: 1786 QE 1787
QE
Sbjct: 190 QE 191
>AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein.
Length = 1337
Score = 72.5 bits (170), Expect = 1e-11
Identities = 149/726 (20%), Positives = 292/726 (40%), Gaps = 71/726 (9%)
Query: 357 RPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADE 416
R + Q+R+ E ++ KL E M E+++++ + + E++
Sbjct: 382 RETDSIQSRKNE-IQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKEL-EEEITL 439
Query: 417 YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
S+ L Q + +L K + +RKAD +K E + + + +++ N+
Sbjct: 440 RKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNS 499
Query: 477 ELEQEVARSTEVALRLQRELAEANS--KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
++ STE +LQR+L E N+ + + ++ Q E+ K + + +D
Sbjct: 500 QI------STEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQD 553
Query: 535 PAQLLRDLQDSLERE-ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE 593
LL + LE+E +L+ L + + + ++ D Q + D+ +
Sbjct: 554 KNCLLETAKLKLEKEFINLQSALESERRDRTHGSEI----INDLQGRICGLEE-DLKNGK 608
Query: 594 TVTNSI--QNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR 651
+ + + + + T KEKS+ + ID T + + S+ A + +
Sbjct: 609 ILLAKVELEKRQLQERFTDLEKEKSN---MEIDMT-----YQLKVIQQSLEQEEAEH--K 658
Query: 652 KTAARVEEDNE--SLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE 709
T AR+ + N+ + + K A K +KL L T E EA+
Sbjct: 659 ATKARLADKNKIYESIEEAKSEAMKEMEKKL--------LEERTLKQKVENLLLEAEKRC 710
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
L +L + + +K+ EL + K+ L + V+ LT KI T+ +R LT
Sbjct: 711 SLLDCDLKQSQ-----QKINELLKQKDVLNEDVRNLTLKIEQETQ---------KRCLTQ 756
Query: 770 NSNKLAEERV---KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK--SRSLD 824
N K+ ++V K+ E ++ + L+E + + E+ +AEL ++ +K L+
Sbjct: 757 NDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLE 816
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK--- 881
A + K Q++ +++E + L+ ++LQ E L ++D
Sbjct: 817 AEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQL 876
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
A + ++ + LE E +IKE+ + E +EK T A+ +ET+ ++
Sbjct: 877 ARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDA--TIASLEETN--RTLTSDVA 932
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDD--AQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
Q L LKD+ + + K + K+ L T+ LK + E
Sbjct: 933 NLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQ---LLTERTLKTQAVNKLAE 989
Query: 1000 IGEMYVVMKNAGLSGKEMTAK--TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
I +K + K KL E+ R KL++ ++ E N +Q +IA+
Sbjct: 990 IMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQ 1049
Query: 1058 VNAKLE 1063
+ +L+
Sbjct: 1050 IRIELQ 1055
Score = 66.1 bits (154), Expect = 1e-09
Identities = 96/414 (23%), Positives = 175/414 (42%), Gaps = 40/414 (9%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALK----KQVKELTSKISS------VT 753
E D K+LL E E L+ + +LE++K ++ Q+K + + T
Sbjct: 601 EEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKAT 660
Query: 754 KTSAGSNTTARRSLT-TNSNKLAEERVKVLEDEI--DEVRKKLIEKERDCERLHAELSLA 810
K S+ S + E K+LE+ +V L+E E+ C L +L +
Sbjct: 661 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQS 720
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
Q+K L+K + + D +N+ LK IEQE L+ +++ T +
Sbjct: 721 QQKINELLKQKDVLNEDVRNLTLK-----IEQETQKRCLTQNDLKMQTQQVNTLKMSEKQ 775
Query: 871 LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK-KE 929
LK + + ++L K+ +L E ++A ++KEL+ + E+ + T+ + KE
Sbjct: 776 LKQENNHLMEMKMNLE-KQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKE 834
Query: 930 TDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL 989
K+K Q + K D+++ + ++ +D L+
Sbjct: 835 ECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSD----LEK 890
Query: 990 KKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQ 1049
+K++++L EI EM K +E+T K ++E L+ + + NEK L
Sbjct: 891 EKIMKEL--EIKEMMARHK------QELTEKDATIASLEETNRTLTSDVANLANEKEELN 942
Query: 1050 TEIAKLKDVNAKLE--GDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQI 1101
KLKDV +L D+++ A KA + E L+ +TL + N+ A+I
Sbjct: 943 N---KLKDVQEQLSRLKDEEISAAAIKA-QFEKQLLTE--RTLKTQAVNKLAEI 990
Score = 59.3 bits (137), Expect = 1e-07
Identities = 145/768 (18%), Positives = 302/768 (39%), Gaps = 93/768 (12%)
Query: 1045 KNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
+N L ++ ++ ++ ++ K+ K LE SN + L ++ K+ ++ K
Sbjct: 371 ENLLLSDSPSCRETDS-IQSRKNEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT 429
Query: 1105 SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX-QVDNYTKIDQDKNKLLKEV 1163
+ +L+ +L+ ++ + + D ++ D N L ++
Sbjct: 430 AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL 489
Query: 1164 GDKTKKIGDXXXXXXXXXXXCKRIEKQ---LSTRKDRVTXXXXXXXXXXXQAVVLANTHR 1220
D K+ + +++++ L T D Q L + +R
Sbjct: 490 EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR 549
Query: 1221 RLSIE---LTSEKDELQARFIKTESKFITLEAEMRD------LKADYENKITSLESTIAA 1271
L + L + K +L+ FI +S LE+E RD + D + +I LE +
Sbjct: 550 DLQDKNCLLETAKLKLEKEFINLQS---ALESERRDRTHGSEIINDLQGRICGLEEDLKN 606
Query: 1272 KDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT 1331
+ + ++E RQ +++ + +E+ Q+E + K
Sbjct: 607 GKILLAKVELEKRQL-QERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLA 665
Query: 1332 EAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL 1391
+ +E A+ ++ + ++E E + LD DL+ ++K+
Sbjct: 666 DKNKIYESIEEAKSEA-MKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKI 724
Query: 1392 DRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALE 1451
+ + KDV N+D TLK +EQ + +LK + ++ V L+ S E
Sbjct: 725 NEL--LKQKDVLNEDVRNLTLK-----IEQETQKRCLTQNDLKMQTQQ-VNTLKMS---E 773
Query: 1452 KAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
K +L +E + + + ++ +EK+ A+ ++KE A G++K LQ++L E
Sbjct: 774 K----------QLKQENNHLMEMKMNLEKQNAE-----LRKERQDADGQMKELQDQLEAE 818
Query: 1512 SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHD 1571
KT+ + L+E C E+ +L L Q+++EL+ D RD L
Sbjct: 819 QYFSTLYKTQ----VRELKEE-C-----EEKTKLGKELQQKKQELQ---DERDSL----- 860
Query: 1572 XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
D E++++ I++ K E+T+
Sbjct: 861 ---AAQLEITLTKADSEQLAR--SIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEK-- 913
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISS 1691
+ + ++ + ++L + V+ E++ L+ Q+ ++ +K+ + SA +I +
Sbjct: 914 --DATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAA----AIKA 967
Query: 1692 TDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYE 1751
E++ + L Q V ++L E ++ K E V + +VR E ++R E
Sbjct: 968 QFEKQLLTERTLKTQAV----NKLAE--IMNRK---EPVKRGNDTDVRRKEKENRKLHME 1018
Query: 1752 EERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
L S R ++ T+ + + KE +E Q + E S + +L+ TL
Sbjct: 1019 ----LKSEREKL----TQQMIKYQKELNEMQAQIAEESQIRIELQMTL 1058
Score = 57.2 bits (132), Expect = 6e-07
Identities = 85/413 (20%), Positives = 180/413 (43%), Gaps = 38/413 (9%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRC--ERVEKEKSDILLRRLANIDTANKYTTGRSSE 318
L D N K Y+ E + + + K+ ER K+K + LL A K + +
Sbjct: 664 LADKN-KIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLE------AEKRCSLLDCD 716
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKI-REIESELETRPSTEAQTRQIEQLR--AKLL 375
+ + QQK+NEL + L ++ ++LT KI +E + T+ + QT+Q+ L+ K L
Sbjct: 717 LKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQL 776
Query: 376 AAET--LCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSL-RRELEQTIK 429
E L E M+ +N +++KE +D +QD +Q +S+L + ++ + +
Sbjct: 777 KQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ--YFSTLYKTQVRELKE 834
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEV- 488
C + K+ ++K +L+ E+ +L + D Q I E + ++
Sbjct: 835 ECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIM 894
Query: 489 -ALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
L ++ +A + T + ++ + + + +LT D A L + ++
Sbjct: 895 KELEIKEMMARHKQELTEKDATIASLEE------TNRTLT-----SDVANLANEKEELNN 943
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQVMTD-NIVTCDIHESETVTNSIQNKMIHA 606
+ D++EQL ++E + + +KQ++T+ + T +++ + N + +
Sbjct: 944 KLKDVQEQLSRLKDEEISAAAIKAQ--FEKQLLTERTLKTQAVNKLAEIMNR-KEPVKRG 1000
Query: 607 ASTPSSKEKSDSPPLSID-KTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
T +++ ++ L ++ K+ E + Y N M A ++ R+E
Sbjct: 1001 NDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIE 1053
Score = 56.4 bits (130), Expect = 1e-06
Identities = 138/734 (18%), Positives = 298/734 (40%), Gaps = 57/734 (7%)
Query: 161 KNDSLAERVRKMQ--LLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDD 218
+ DS+ R ++Q L + E ++E E++ S + EKTA+ +E + +
Sbjct: 383 ETDSIQSRKNEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKS 442
Query: 219 V-NFLMQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLK 277
V + L Q++ + K ++++V +DQ+E LK
Sbjct: 443 VESALRQLEREKALLQHK---------NAEYQRKADHEADKKRNLENDVNSLKDQLEDLK 493
Query: 278 QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ----QKVNELTTHN 333
+ R + ++ EK + L R+L + + + ++ + K Q +++ +L ++N
Sbjct: 494 K-----RNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNN 548
Query: 334 EDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQ-------IEQLRAKLLAAETLCEE-- 383
DL+D+ L ++E E + + + E++ R I L+ ++ E +
Sbjct: 549 RDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGK 608
Query: 384 -LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTE 442
L+ + E K++L++ + N D + +++ LEQ + +L
Sbjct: 609 ILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKN 668
Query: 443 RKADQLEQEKA----EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ + +E+ K+ E EKKLLE + EN + E E+ + + Q+++ E
Sbjct: 669 KIYESIEEAKSEAMKEMEKKLLE--ERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINE 726
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGG--SQEDPAQLLRDLQDSLEREAD-LREQ 555
+ N + + + + LT+ Q L+ + L++E + L E
Sbjct: 727 LLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEM 786
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE- 614
N E++ A ++ + + D + + T + K T KE
Sbjct: 787 KMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKEL 846
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
+ L ++ + Q L +A + + + +E++ L++K+M
Sbjct: 847 QQKKQELQDERDSLAAQLEITLTKAD-SEQLARSIAEEQYSDLEKEKIMKELEIKEM--M 903
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
AR ++ A S+E N + + +L +L + + + R K EE+
Sbjct: 904 ARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAA 963
Query: 735 --KEALKKQ-VKELTSKISSVTKTSAGSN--TTARRSLTTNSNKLAEERVKV---LEDEI 786
K +KQ + E T K +V K + N +R T+ + +E K+ L+ E
Sbjct: 964 AIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSER 1023
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV--IEQEA 844
+++ +++I+ +++ + A+ +A++ + +LD+ D L+ QLQ I ++
Sbjct: 1024 EKLTQQMIKYQKELNEMQAQ--IAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDS 1081
Query: 845 SVLRAKTQSLEADN 858
S + + EAD+
Sbjct: 1082 SSIGSGPGDAEADD 1095
Score = 50.0 bits (114), Expect = 8e-05
Identities = 144/729 (19%), Positives = 278/729 (38%), Gaps = 87/729 (11%)
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD 880
R D+ + +++++L +E+ S + Q+ E +K ++ N +L+ K AK L +
Sbjct: 382 RETDSIQSRKNEIQKKLYTLEEHLS---NEMQAKEELEQKCKSVNTRLE--KTAKELEEE 436
Query: 881 KALDLNTKKTT-QLENELKEALAKIKELEMICQ-DEKSEKKVRF---TEATKKETDTLKS 935
L + + QLE E +AL + K E + D +++KK + K + + LK
Sbjct: 437 ITLRKSVESALRQLERE--KALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKK 494
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED 995
+ A L++ D A + K T+ + K ++
Sbjct: 495 RNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRK-----------TQAESSKQIQQ 543
Query: 996 LECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKL 1055
LE ++ KN L TAK KLEKE ++S L + T+ + ++
Sbjct: 544 LESNNRDLQD--KNCLLE----TAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRI 597
Query: 1056 KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+ L+ K + A +E E L + L +E N E ++ LK +Q
Sbjct: 598 CGLEEDLKNGKILLAK----VELEKRQLQERFTDLEKEKSNMEID---MTYQLK---VIQ 647
Query: 1116 TTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXX 1175
++ + Y I++ K++ +KE+ KK+ +
Sbjct: 648 QSLEQ----------EEAEHKATKARLADKNKIYESIEEAKSEAMKEM---EKKLLEERT 694
Query: 1176 XXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQA 1235
EK+ S + Q VL R L++++ E
Sbjct: 695 LKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQE------ 748
Query: 1236 RFIKTESKFITLEAEMRDLKADYE--NKITSLESTIAAKDVHIKQLEDAL-RQTTNDKYD 1292
T+ + +T DLK + N + E + ++ H+ +++ L +Q + +
Sbjct: 749 ----TQKRCLT----QNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKE 800
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL 1352
+ +M E++ + ++ K E+ E ++ K E+ Q K +L
Sbjct: 801 RQDADGQMKELQDQLEAEQYFSTLYKTQVRELK---EECEEKTKLGK-ELQQKKQELQDE 856
Query: 1353 ENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER--KKLD--RMRIAHDKDVKNKDAE 1408
+ + A+E +DL+ E+ K+L+ M H +++ KDA
Sbjct: 857 RDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDAT 916
Query: 1409 LATLKGKLKILEQNSGAGAKRITELKQEYEETVKKL------EHSLALEKAEYEELTGKY 1462
+A+L+ + L + A EL + ++ ++L E S A KA++E+
Sbjct: 917 IASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTE 976
Query: 1463 ELLEEEHVVTKARLTVEKEQAQG----ELLHVQKELSTALGEIKTLQEKLGTESAAWNTE 1518
L+ + V A + KE + ++ +KE E+K+ +EKL + + E
Sbjct: 977 RTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKE 1036
Query: 1519 KTEMQNSIA 1527
EMQ IA
Sbjct: 1037 LNEMQAQIA 1045
>Z75311-1|CAA99729.1| 1318|Homo sapiens RAD50 homologue hsRAD50
protein.
Length = 1318
Score = 72.1 bits (169), Expect = 2e-11
Identities = 149/822 (18%), Positives = 337/822 (40%), Gaps = 59/822 (7%)
Query: 263 DSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKSDILL---RRLANIDTANKYTTGRSSE 318
+S ++E +++ +G ++++ L +R +EK L+ R L ++ ++ SE
Sbjct: 292 NSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSE 351
Query: 319 VLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQL-RAKLL 375
+L Q ++ + H E +R + ++E + E P +E Q + +L R +
Sbjct: 352 LLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE 411
Query: 376 AAETLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR 432
+LM+ E E +K++ D E +++ S + EL KN +
Sbjct: 412 GEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNEL----KNVK 467
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
+L+ + + +L+QE + E++L + + + + L+ E A +L
Sbjct: 468 YELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKL 527
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+E+ + N T + + + + + K + + ++ LL + + E L
Sbjct: 528 DQEMEQLN-HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWL 586
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
+ + + ++N +Q N + ++ E +S ++K+ +
Sbjct: 587 HSKSKEINQTRDRLAKLNKELASSEQ--NKNHINNELERKEEQLSSYEDKLFDVCGSQDF 644
Query: 613 KEKSDSPPLSIDKTTEETQF--HFDLPYLSIFNHMAANNLR--KTAARVEEDNESLLLQL 668
+ D I+K++++ Y + N RV + L +
Sbjct: 645 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEAI 704
Query: 669 KKMATKARSRKLSPTPPANKL-SIETANDNDEKETDE-ADPAEMK-LLLELNEQEATVLR 725
+ +K R L+P +KL S E+ EK DE A M+ +++L E+E LR
Sbjct: 705 SDLQSKLR---LAP----DKLKSTESELKKKEKRRDEMLGLAPMRQSIIDLKEKEIPELR 757
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
K++ + +D + LK ++E + + ++ +A+ LT + ER ++ E
Sbjct: 758 NKLQNVNRDIQRLKNDIEEQETLLGTIMP----EEESAKVCLT---DVTIMERFQM---E 807
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+ +V +K+ ++ + + + ++ Q + K LD + ++L R+L + +Q+
Sbjct: 808 LKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK-IELNRKL-IQDQQEQ 865
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK 905
+ K+ + E +EKLQ L+ + L ++ ++L+T + L E+K+A ++
Sbjct: 866 IQHLKSTTNELKSEKLQISTN----LQRRQQL-EEQTVELST-EVQSLYREIKDAKEQVS 919
Query: 906 ELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
LE + + EK+ E K+ + K Q + ++ K
Sbjct: 920 PLETTLEKFQQEKE----ELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENHIQDGK 975
Query: 966 DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
DD K + + K L+ + +K E + ++ M + + + + L K
Sbjct: 976 DDYMKQKETELNKVIAQLS---ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRK 1032
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKD 1067
+E++ ++ + + E ++Q + ++K + KLE + D
Sbjct: 1033 RNEELK-EVEEEGKQHLKEMGQMQ--VLQMKSEHQKLEENID 1071
Score = 61.3 bits (142), Expect = 3e-08
Identities = 168/887 (18%), Positives = 335/887 (37%), Gaps = 84/887 (9%)
Query: 277 KQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDL 336
K E L R + + L + A ID + G S VL N + H ED
Sbjct: 114 KTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLN-----NVIFCHQEDS 168
Query: 337 R---DEKKHLTQKIREIESE------LET-RPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
E K L QK EI S LET R + Q +++E+ + +L + E+ +
Sbjct: 169 NWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVEEYQMELKYLKQYKEKACE 228
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ + + L ++ E++ D + +E+E + L ++K + +
Sbjct: 229 IRDQITSKEAQLTSSKEIVKSY--ENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKK 286
Query: 447 QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAEAN--SKF 503
Q+E++ +E E+K+ ++ G D ++ N + Q R E L REL + N S+
Sbjct: 287 QMEKDNSELEEKMEKVFQGTD--EQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRL 344
Query: 504 TGSNPSLMKVPQPE-TVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLEREADLREQLRN--- 558
S + V Q ++ R L L+ D ER Q++N
Sbjct: 345 LNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHK 404
Query: 559 --AEEETANCKQVNP--PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKE 614
E + K N F +K+ + + +I + +T I S ++
Sbjct: 405 LVRERQEGEAKTANQLMNDFAEKETLKQKQID-EIRDKKTGLGRIIELKSEILSKKQNEL 463
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
K+ L + + + D + ++ ++ E + LQ +K
Sbjct: 464 KNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLK--MEVISLQNEKADLD 521
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLELNEQEATVLR---RKVEE 730
RKL T + D+AD E ++ + + E T L ++
Sbjct: 522 RTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQ 581
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
LE + K++ + +++ + K A S ++ N + EE++ ED++ +V
Sbjct: 582 LEDWLHSKSKEINQTRDRLAKLNKELASSE--QNKNHINNELERKEEQLSSYEDKLFDVC 639
Query: 791 KKLIEKERDCERLHAELSLAQKK-----PKTLIKSRSLDASDQQN----------VDLKR 835
+ E D +RL E+ + K+ T + S+ + +N +
Sbjct: 640 GSQ-DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEA 698
Query: 836 QLQ-VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+LQ I S LR L++ +L+ + K+ + +R +DL K+ +L
Sbjct: 699 ELQEAISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPMR-QSIIDLKEKEIPELR 757
Query: 895 NELKEALAKIKELEMICQD----------EKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
N+L+ I+ L+ ++ E+ KV T+ T E ++ K
Sbjct: 758 NKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKD---VERK 814
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEM 1003
T++ + + Q+ K +++K++L +K+++D + +I
Sbjct: 815 IAQQAAKLQGIDLDRTVQQVNQEKQEK-----QHKLDTVSSKIELNRKLIQDQQEQI--Q 867
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
++ L +++ T L++ R +L + E + E L EI K+ + LE
Sbjct: 868 HLKSTTNELKSEKLQISTNLQR-----RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLE 922
Query: 1064 GDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
+ F + + L N+ + + + ++K + I+ D++N
Sbjct: 923 TTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIEN 969
Score = 47.6 bits (108), Expect = 5e-04
Identities = 79/406 (19%), Positives = 160/406 (39%), Gaps = 23/406 (5%)
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS-LTT 769
KL+ E E EA + + + + + +KQ+ E+ K KT G + L+
Sbjct: 404 KLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDK-----KTGLGRIIELKSEILSK 458
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
N+L + VK +++ +++E +++ + ELS A+K + + +
Sbjct: 459 KQNEL--KNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 516
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL--NT 887
DL R L+ ++QE L T + + + K + ++ KS SD+ L
Sbjct: 517 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYF 576
Query: 888 KKTTQLENELKEALAKIKELEMICQD-EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
QLE+ L +K KE+ K K++ +E K + ++
Sbjct: 577 PNKKQLEDWLH---SKSKEINQTRDRLAKLNKELASSEQNKNHINNELERKEEQLSSYED 633
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPR-IPKKPTDLTTKLQLKKMVEDLECEIGEMYV 1005
++ L LK++ +KS K R + T + ++ + E+ C V
Sbjct: 634 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 693
Query: 1006 VMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
A L ++KL D KL +SE +K + + E+ L + +
Sbjct: 694 FQTEAELQEAISDLQSKLRLAPD----KLKSTESEL-KKKEKRRDEMLGLAPMRQSI--- 745
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
D+ + L N+ N++ + L +++ +E + + + ++A
Sbjct: 746 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 791
Score = 44.4 bits (100), Expect = 0.004
Identities = 109/606 (17%), Positives = 242/606 (39%), Gaps = 51/606 (8%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
N K+ +D + +E++ R R ++ KE L N + N + ++ +
Sbjct: 578 NKKQLEDWLHSKSKEINQTRDRLAKLNKE----LASSEQNKNHINNELERKEEQLSSYED 633
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLAAETLCEE 383
K+ ++ ++D + L ++I + + A Q I QL + + +C+
Sbjct: 634 KLFDVCG-SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQR 692
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSFKLKKTE 442
+ ++++ + DL D + +++ + RR+ + R LK E
Sbjct: 693 VFQTEAELQEAISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPMRQSIIDLK--E 750
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL--EQEVARS--TEVAL--RLQREL 496
++ +L + + + + D ++E + + E+E A+ T+V + R Q EL
Sbjct: 751 KEIPELRNKLQNVNRDIQRLKN--DIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL 808
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL-REQ 555
+ K L + TV+ QE +L D++ + +L R+
Sbjct: 809 KDVERKIAQQAAKLQGIDLDRTVQQVNQE-----KQEKQHKL-----DTVSSKIELNRKL 858
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
+++ +E+ + K +K ++ N+ E +TV S + + ++ +KE+
Sbjct: 859 IQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYR-EIKDAKEQ 917
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE------EDNESLLLQLK 669
+++K +E + + S N +A + L +V+ +D E+ + K
Sbjct: 918 VSPLETTLEKFQQEKEELINKKNTS--NKIAQDKLNDIKEKVKNIHGYMKDIENHIQDGK 975
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE------QEATV 723
K + +L NK+ + + KE D M+ ++ + Q+
Sbjct: 976 DDYMKQKETEL------NKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLT 1029
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
LR++ EEL++ +E K+ +KE+ ++ + S ++ LA R K E
Sbjct: 1030 LRKRNEELKEVEEEGKQHLKEM-GQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYE 1088
Query: 784 DEIDEVRKKLIEKE-RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQ 842
+EI +K+L E + RD E + E+ + + + + K + +K +E+
Sbjct: 1089 EEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEE 1148
Query: 843 EASVLR 848
++R
Sbjct: 1149 INKIIR 1154
>DQ109808-1|AAZ83370.1| 2479|Homo sapiens nephrocystin-6 protein.
Length = 2479
Score = 72.1 bits (169), Expect = 2e-11
Identities = 174/861 (20%), Positives = 361/861 (41%), Gaps = 85/861 (9%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
S +++Y +E +Q LRK E+ + E + I ++ ++ LQ
Sbjct: 895 SLIRQYTTLVELERQ----LRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQ 950
Query: 324 QKVNELTTHNE-DLRDEK-KHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
+ V+ + +E +L +++ LT K R+I L+ +T +E L + ++ +
Sbjct: 951 KVVDNSVSLSELELANKQYNELTAKYRDI---LQKDNMLVQRTSNLEHLECENISLKEQV 1007
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E + E E K++L + +E + SS+ + +++I N ++S K T
Sbjct: 1008 ESINKELEITKEKLHTIEQAWE------QETKLGNESSMDKA-KKSITNSDIVSISKKIT 1060
Query: 442 ERKADQL-EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN 500
+ +L E+++AEH +K+ E + Q E R ELE + A T++ L Q+
Sbjct: 1061 MLEMKELNERQRAEHCQKMYEHLR-TSLKQMEERNFELETKFAELTKINLDAQKVEQMLR 1119
Query: 501 SKFTGS-NPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD-LREQLRN 558
+ S + ++ + +++ ++ + + LR++ D R+ + L Q ++
Sbjct: 1120 DELADSVSKAVSDADRQRILELEKNEM----ELKVEVSKLREISDIARRQVEILNAQQQS 1175
Query: 559 AEEETANCKQVNPPTFLDKQVMTDN-IVTCDIHESETVTNSIQNKMIHAASTPSSK-EKS 616
++E + + LD Q +D + +H+ + + + +SK +K
Sbjct: 1176 RDKEVESLRM----QLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKM 1231
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
++ L +++ +E + L Y + A +LR+T +SL Q A+
Sbjct: 1232 EAYNLRLEQKLDEKEQA--LYYARLEGRNRAKHLRQTI-------QSLRRQFSGALPLAQ 1282
Query: 677 SRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE 736
K S T I+ ND ++K++ E+ + R +E + E
Sbjct: 1283 QEKFSKT------MIQLQND------------KLKIMQEMKNSQQE--HRNMENKTLEME 1322
Query: 737 ALKKQVKELTSKISSVTKTSAGSNTTAR-RSLTTNSNKLAEERVKVLEDEIDEVRKKLIE 795
K ++EL S + N + L KL E VK E EI + + E
Sbjct: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKE-EIKYLNNIISE 1381
Query: 796 KERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLE 855
ER L E+ + Q K + R + A DQ+ VDL+RQL + +++ + + Q E
Sbjct: 1382 YERTISSLEEEI-VQQNK---FHEERQM-AWDQREVDLERQLDIFDRQQNEILNAAQKFE 1436
Query: 856 ADNEKLQTENKKL--QLLKNAKSLRSDKALDLNTKKTTQ-LENEL--KEALAKIKELEMI 910
+ + L QL + ++ + + L T+ T + LE +L KE+ ++ E ++
Sbjct: 1437 EATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNIL 1496
Query: 911 CQDEK-SEKKVRFTEATKKETDTLK-SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+D+ +E ++R ++E + ++ QA L K++
Sbjct: 1497 SRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ-KEEV 1555
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
K ++ R+ +K + ++ +KK EDL + + ++ L+ + TA +++
Sbjct: 1556 LKKYQ-RLLEKAREEQREI-VKKHEEDLHI-LHHRLELQADSSLNKFKQTAWDLMKQSPT 1612
Query: 1029 EIRS-----KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
+ + +L++ + + + L + + KLK V+ LE +++ K K EN L
Sbjct: 1613 PVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQL 1672
Query: 1084 SNQCKTLTEEMKNREAQINKL 1104
+ +E+K +A++ L
Sbjct: 1673 QENHE---DEVKKVKAEVEDL 1690
Score = 68.9 bits (161), Expect = 2e-10
Identities = 170/817 (20%), Positives = 337/817 (41%), Gaps = 67/817 (8%)
Query: 134 KRRLTGPLPDLDTGQTTNGSQ-TQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEKER- 191
KR T L D T N SQ +++ K D L+ ++ M +++N F IEKER
Sbjct: 565 KRSATSGLTTEDLNLTENISQGDRISERKLDLLS--LKNMSEAQSKNEFLSRELIEKERD 622
Query: 192 -ERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGG------PXX 244
ER +K K +E ++ + ++Q P V+GG P
Sbjct: 623 LERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKD---PDVKGGETSLIIPSL 679
Query: 245 XXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN 304
++K DQ+ G +E+ + + S L +
Sbjct: 680 ERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLK 739
Query: 305 IDTANKYTTG-RSSEVLKLQQKVNELT-----THNEDLRDEKKHLTQKIREIESELETRP 358
ID K T+ R SE + K +L + + + ++L ++E+E++ +
Sbjct: 740 IDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLK 799
Query: 359 STEAQTRQIEQLRAKLLAAETLC-EELMDENEDMKKELRDLXXXXXXMQDNFRED--QAD 415
+ E + A + ++L +E + E E K E + + ++D ++D +
Sbjct: 800 NLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVK 859
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
EY++L L+ + + L + RK L+ + ++ +V +++EN
Sbjct: 860 EYNNLLNALQMDSDEMKKI---LAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENE- 915
Query: 476 KELEQEVARSTEVALR---LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ 532
K+ + ++ EV + LQR A K +L KV VS S L Q
Sbjct: 916 KQKNELLSMEAEVCEKIGCLQRFKEMAIFKIA----ALQKVVDNS---VSLSELELANKQ 968
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
+ +L +D L+++ L ++ N E C+ ++ ++ I +H
Sbjct: 969 YN--ELTAKYRDILQKDNMLVQRTSNLEH--LECENISLKEQVESINKELEITKEKLHTI 1024
Query: 593 ETVTNSIQNKMIHAASTPSSKEK-SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAA--NN 649
E + K+ + +S +K+ ++S +SI K + +L H +
Sbjct: 1025 EQAWEQ-ETKLGNESSMDKAKKSITNSDIVSISKKITMLEMK-ELNERQRAEHCQKMYEH 1082
Query: 650 LRKTAARVEEDN---ESLLLQLKKMATKARS-RKLSPTPPANKLSIETANDNDEKETDEA 705
LR + ++EE N E+ +L K+ A+ ++ A+ +S + +D D + E
Sbjct: 1083 LRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVS-KAVSDADRQRILEL 1141
Query: 706 DPAEMKLLLELNE--QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
+ EM+L +E+++ + + + RR+VE L +++ K+V+ L ++ S + A
Sbjct: 1142 EKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIA 1201
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL 823
+ S +L+E +++ + KL + E RL +L +K + L +R L
Sbjct: 1202 KLHQHNVSLQLSEATAL---GKLESITSKLQKMEAYNLRLEQKL---DEKEQALYYAR-L 1254
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKAL 883
+ ++ L++ +Q + ++ S Q + +Q +N KL++++ K+ + +
Sbjct: 1255 EGRNRAK-HLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHR- 1312
Query: 884 DLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKV 920
N + T LE ELK L ++EL +D K +KV
Sbjct: 1313 --NMENKT-LEMELK--LKGLEELISTLKDTKGAQKV 1344
Score = 65.3 bits (152), Expect = 2e-09
Identities = 148/729 (20%), Positives = 315/729 (43%), Gaps = 80/729 (10%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
+ S +K ++E +EV+ + + E + +++ ++ A + GR + L
Sbjct: 54 ITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFL 113
Query: 321 KLQ--QKVNELTTHNEDLRDEKKHLTQKIREIESELETR-PSTEAQTRQIEQLRAKLLAA 377
+ + Q +L + +L D +K L +K +++ +L R E + ++ + +L
Sbjct: 114 RNEICQLEKQLEQKDRELEDMEKEL-EKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
Query: 378 -ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
E LC++++D + + + L +D+ D + S EL Q + + L+
Sbjct: 173 NEQLCQDIIDYQKQIDSQKETLLSRRG--EDS---DYRSQLSKKNYELIQYLDEIQTLTE 227
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGM-----QRENRIKELEQEVARSTEVALR 491
+K E + ++ + E +++ ++ + M Q +N I +L++E + L+
Sbjct: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKE---NDHYQLQ 284
Query: 492 LQRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER-- 548
+Q SK +P ++ V + E K+ SS + + Q+L +L++ L+
Sbjct: 285 VQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSS--KDDEIIEYQQMLHNLREKLKNAQ 342
Query: 549 -EADLREQL---RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
+AD + + +E + K + + M N TC I E + N +Q
Sbjct: 343 LDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN--TCII---EDLKNELQRNKG 397
Query: 605 HAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--- 661
+ + + K S + + T+E + +L L + R+++
Sbjct: 398 ASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADA--REKDKELVEALKRLKDYESGV 455
Query: 662 ---ESLLLQLK--KMATKARSRKLSP-TPPANKLSIETANDNDEKET-DEADPAEMKLLL 714
E ++++K K K R R++ T NKL ++ ++ DE E E E K ++
Sbjct: 456 YGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMI 515
Query: 715 ELNE-------------QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+L E E +L +++E LE+++ LKK+++++ + + TS T
Sbjct: 516 DLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG--LT 573
Query: 762 TARRSLTTN---SNKLAEERVKVLE-DEIDEVRKK-------LIEKERDCERLHAELSLA 810
T +LT N ++++E ++ +L + E + K LIEKERD ER ++
Sbjct: 574 TEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKF 633
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL--QTENKKL 868
Q K K L++ ++ ++ + ++ ++++ V +T + E+L E+K
Sbjct: 634 QNKLKELVEENK--QLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNA 691
Query: 869 QLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKK 928
+ + +A SL +D T + +L EL+E ++ + + Q K+ K+ E K
Sbjct: 692 EGIFDA-SLHLKAQVDQLTGRNEELRQELRE--SRKEAINYSQQLAKANLKIDHLE---K 745
Query: 929 ETDTLKSKQ 937
ET L+ +
Sbjct: 746 ETSLLRQSE 754
Score = 63.3 bits (147), Expect = 9e-09
Identities = 170/870 (19%), Positives = 360/870 (41%), Gaps = 80/870 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ V E D + L ++ + + ER ++E +++ ++ NI + EV K
Sbjct: 1626 MEQTVAEQDDSLSSLLVKLKKVSQDLER-QREITELKVKEFENIKL--QLQENHEDEVKK 1682
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE--- 378
++ +V +L + + E + L ++ + + E +R T +E+L+++L E
Sbjct: 1683 VKAEVEDLKYLLDQSQKESQCLKSEL-QAQKEANSRAPTTTMRNLVERLKSQLALKEKQQ 1741
Query: 379 -TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ--ADEYS-SLRRELEQTIKNCRVL 434
L L++ +M + ++ Q D ++ L+ ++E +N L
Sbjct: 1742 KALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKL 1801
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
LK ++ + + L + +L + + + RE +E++QE + E+ +++R
Sbjct: 1802 KEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREK--EEIDQE---NDELKRQIKR 1856
Query: 495 ELAEANSK-FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
+ K T + SL++ Q + K+ + + ++ ++ L R + +
Sbjct: 1857 LTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGK 1916
Query: 554 EQLRNAEEETANCKQVNPPTF-LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
+ E K+ F L KQ+ T + + E +T +Q K+ T
Sbjct: 1917 KWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKA-DKEKLT--LQRKLKTTGMTVD- 1972
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN-ESLLLQLKKM 671
+ L +K EE + +L + +M A+ + VE+ + ++ LQ K
Sbjct: 1973 -QVLGIRALESEKELEELKKR-NLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
Query: 672 ATKARSRKLSPTPPANKLSIETANDNDEKETD--------EADPAEMKLLLELNEQEATV 723
A + + K + + P+ +S ++D+ ++E + ++ E+K LE ++
Sbjct: 2031 ALEKQFSKDTYSKPS--ISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPR 2088
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L+ +V +L++ E LKK+ E+ K+ V GS S K E K +
Sbjct: 2089 LKNQVRDLKEMCEFLKKEKAEVQRKLGHV----RGSG---------RSGKTIPELEKTI- 2134
Query: 784 DEIDEVRKKLIEK-ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE- 841
+ KK++EK +R+ E+L KK ++ S + +Q+N LK +L+ ++
Sbjct: 2135 ----GLMKKVVEKVQRENEQL--------KKASGILTSEKMANIEQENEKLKAELEKLKA 2182
Query: 842 ----QEASVLRAKTQSLE---ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
Q + +KT+ E A+NE+L+ E KK + + LN K T QLE
Sbjct: 2183 HLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLE 2242
Query: 895 NELKE-ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
K A+ + ++ D KS K + T + + L++
Sbjct: 2243 ETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKE 2302
Query: 954 XXXXQATLKSLKDDAQKSFK-----PRIPKKPTDLTTKLQLKKMV-EDLECEIGEM-YVV 1006
+ + +D ++ K P + L +LQ+ ++ L+ E E+ + +
Sbjct: 2303 ATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQI 2362
Query: 1007 MKNAGLSGKEMTA--KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
N SG E T +L+++I ++ ++L +D E + K ++ +L++ +
Sbjct: 2363 EANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE 2422
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEM 1094
+ + YK +N L + K L+E++
Sbjct: 2423 EIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
Score = 62.9 bits (146), Expect = 1e-08
Identities = 187/919 (20%), Positives = 358/919 (38%), Gaps = 110/919 (11%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDIL-----LRRLANID--TANKYTTGRSSE 318
+K ++QI+ +E++IL K ++E + SD L LR ++ T T R+S+
Sbjct: 465 IKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSK 524
Query: 319 VLKLQQKVNE---LTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
LK QQ E L E L +E+ L +KIR++ E R +T T + L +
Sbjct: 525 HLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENIS 584
Query: 376 AAETLCEELMD------------ENEDMKKEL----RDLXXXXXXMQ--DNFREDQADEY 417
+ + E +D +NE + +EL RDL + N ++ +E
Sbjct: 585 QGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEEN 644
Query: 418 SSLR---RELEQTIKNCRV--------LSFKLKKTERKADQLEQEKAEHE-KKLLEIVGG 465
L +E+ Q IK + S + ER + +E + AE L +
Sbjct: 645 KQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQ 704
Query: 466 PDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSS 525
D Q R +EL QE+ S + A+ ++LA+AN K + Q E V
Sbjct: 705 VD--QLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKG 762
Query: 526 L-TRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI 584
+ G A ++ + L L ++L N E++ N + D++
Sbjct: 763 IDLPDGIAPSSASIINSQNEYL---IHLLQELENKEKKLKN--------------LEDSL 805
Query: 585 VTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDL----PYLS 640
D + V Q+ + + K++S + +K E Q D Y +
Sbjct: 806 E--DYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNN 863
Query: 641 IFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK 700
+ N + ++ E + +LQ+ + + + L +L E +E
Sbjct: 864 LLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTL--VELERQLRKENEKQKNEL 921
Query: 701 ETDEADPAE----MKLLLELNEQEATVLRRKVEELE--QDKEALKKQVKELTSKISSVTK 754
+ EA+ E ++ E+ + L++ V+ + E KQ ELT+K + +
Sbjct: 922 LSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQ 981
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
N +R T+N L E + L+++++ + K+L E E+LH + A ++
Sbjct: 982 K---DNMLVQR--TSNLEHLECENIS-LKEQVESINKEL---EITKEKLHT-IEQAWEQE 1031
Query: 815 KTLIKSRSLD-----ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQ 869
L S+D ++ V + +++ ++E + R + + + E L+T K+++
Sbjct: 1032 TKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQME 1091
Query: 870 --LLKNAKSLRSDKALDLNTKKTTQ-LENELKEALAKI---KELEMICQDEKSEKKVRFT 923
+ ++L+ +K Q L +EL ++++K + + I + EK+E +++
Sbjct: 1092 ERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVE 1151
Query: 924 EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL 983
+ +E + +Q Q L AQ K I K
Sbjct: 1152 VSKLREISDIARRQVEILNAQQQSRDKEVESLRMQL----LDYQAQSDEKSLIAKLHQH- 1206
Query: 984 TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
LQL + +G++ + K +LE+++DE L E N
Sbjct: 1207 NVSLQLSEAT-----ALGKLESITSKL---QKMEAYNLRLEQKLDEKEQALYYARLEGRN 1258
Query: 1044 EKNRLQTEIAKL-KDVNAKLE-GDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQI 1101
L+ I L + + L ++ F+ L+N+ + + K +E +N E +
Sbjct: 1259 RAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKT 1318
Query: 1102 NKLSADLKNATSLQTTMSD 1120
++ LK L +T+ D
Sbjct: 1319 LEMELKLKGLEELISTLKD 1337
Score = 52.8 bits (121), Expect = 1e-05
Identities = 158/868 (18%), Positives = 347/868 (39%), Gaps = 82/868 (9%)
Query: 273 IEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTH 332
I + +++ +L + E E+++++ + ++ T+ K R+ E L+ K ELT
Sbjct: 1052 IVSISKKITMLEMK-ELNERQRAEHCQKMYEHLRTSLKQMEERNFE---LETKFAELTKI 1107
Query: 333 NEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD------ 386
N D + ++ L ++ + S+ + + + ++E+ +L + E+ D
Sbjct: 1108 NLDAQKVEQMLRDELADSVSKAVSDADRQ-RILELEKNEMELKVEVSKLREISDIARRQV 1166
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYS----------SLRRELEQTIKNCRVLSF 436
E + +++ RD MQ + Q+DE S SL+ + ++
Sbjct: 1167 EILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITS 1226
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
KL+K E +LEQ+ E E+ L +G R +++ Q + R AL L ++
Sbjct: 1227 KLQKMEAYNLRLEQKLDEKEQALY--YARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQE 1284
Query: 497 AEANSKFTGSNPSL-----MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
+ + N L MK Q E + +L + +L+ L+D+ +
Sbjct: 1285 KFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKV 1344
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMT--DNIVTCDIHESETVTNSIQNKMIHAAST 609
+ ++ E K +N DK+ + +NI++ E E +S++ +++
Sbjct: 1345 INWHMKIEELRLQELK-LNRELVKDKEEIKYLNNIIS----EYERTISSLEEEIVQQNKF 1399
Query: 610 PSSKEKS-DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
++ + D + +++ + FD I N AA + + + + L QL
Sbjct: 1400 HEERQMAWDQREVDLERQLDI----FDRQQNEILN--AAQKFEEATGSIPDPSLPLPNQL 1453
Query: 669 KKMATKARSR-KLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRK 727
+ K + ++ A S+E KE + A + +L ++ + R
Sbjct: 1454 EIALRKIKENIRIILETRATCKSLE----EKLKEKESALRLAEQNILSRDKVINELRLRL 1509
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
E++K + KE+ K K + T A N + ++ + L ++
Sbjct: 1510 PATAEREKLIAELGRKEMEPKSHHTLKIA--HQTIANMQARLNQKEEVLKKYQRLLEKAR 1567
Query: 788 EVRKKLIEK-ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDL---KRQLQVIEQE 843
E ++++++K E D LH L L K + D Q + K +++ E E
Sbjct: 1568 EEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEME 1627
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+V + SL + KL+ ++ L+ + L+ + ++ + E+E+K+ A+
Sbjct: 1628 QTVAE-QDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAE 1686
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSK-QXXXXXXXXXXXXXXXXXXXXQATLK 962
+++L+ + + ++KE+ LKS+ Q +
Sbjct: 1687 VEDLKYLL------------DQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQL 1734
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-- 1020
+LK+ QK+ + + ++T + ++++ K A L+ +++ +
Sbjct: 1735 ALKEKQQKALSRALLELRAEMTAAAE-ERIISATS---------QKEAHLNVQQIVDRHT 1784
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVF---ANKYKALE 1077
+L+ +++++ L K KNR + L D+N +L+ + + + + ++
Sbjct: 1785 RELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEID 1844
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLS 1105
EN L Q K LT ++ + NK S
Sbjct: 1845 QENDELKRQIKRLTSGLQGKPLTDNKQS 1872
Score = 43.6 bits (98), Expect = 0.007
Identities = 101/496 (20%), Positives = 199/496 (40%), Gaps = 32/496 (6%)
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L L K E ++L+ EK E+ L I M+ + LE EV ++ E + +
Sbjct: 28 LLISLSKVE--VNELKSEKQENVIHLFRITQSLMKMKAQEVELALE-EVEKAGEEQAKFE 84
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ-EDPAQLLRDLQDSLEREADL 552
+L K + + R+ + + Q E + L D++ LE+E +
Sbjct: 85 NQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKV 144
Query: 553 REQ--LRNAEEETANCKQVNPPTFLDKQVMTDNIVTC-DIHESETVTNSIQNKMIHAAST 609
EQ LRN E E N K +K++ N C DI + + +S + ++
Sbjct: 145 NEQLALRNEEAENENSKLRRE----NKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRG- 199
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
E SD K E Q+ ++ L+ N ++ +EE + +++
Sbjct: 200 ----EDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEES----VQEME 251
Query: 670 KMATKARSRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
KM + K N + ++ ND+ + + E +K E ++ + KV
Sbjct: 252 KMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKV 310
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER---VKVLEDE 785
EE + + ++ E + ++ + + A +S + +ER +K+L ++
Sbjct: 311 EEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQ 370
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+++ K++ + E L EL K TL S+ Q +D+ ++ + E E +
Sbjct: 371 VEQYTKEMEKNTCIIEDLKNELQ-RNKGASTL--SQQTHMKIQSTLDILKE-KTKEAERT 426
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL-NTKKTTQLENELKEALAK- 903
A+ + E D E ++ K+L+ ++ D +++ N K ++ + E L K
Sbjct: 427 AELAEADAREKDKELVEA-LKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKE 485
Query: 904 IKELEMICQDEKSEKK 919
I +LE+ D E +
Sbjct: 486 INKLELKISDFLDENE 501
Score = 42.7 bits (96), Expect = 0.013
Identities = 86/420 (20%), Positives = 175/420 (41%), Gaps = 46/420 (10%)
Query: 700 KETDEADPAEMKLLLELNEQEATVLRR-KVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
KE + DP ++ EL + L + +V EL+ +K+ + V L S+ K A
Sbjct: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQ---ENVIHLFRITQSLMKMKAQ 64
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
A + K EE+ K E+++ + K+++ E + E A+ S + + L
Sbjct: 65 EVELALEEV----EKAGEEQAK-FENQL---KTKVMKLENELEM--AQQSAGGRDTRFLR 114
Query: 819 KS-----RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKN 873
+ L+ D++ D++++L+ ++ L + + E +N KL+ ENK+L+ K
Sbjct: 115 NEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLK--KK 172
Query: 874 AKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTL 933
+ L D +D + +Q E L + E S+ + + ++ + L
Sbjct: 173 NEQLCQD-IIDYQKQIDSQKETLLSR------------RGEDSDYRSQLSKKNYELIQYL 219
Query: 934 KSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMV 993
Q + +++ ++ + + + TD QLKK
Sbjct: 220 DEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVID-QLKKEN 278
Query: 994 EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIA 1053
+ + ++ E+ ++K+ + ++ + +++E + LS D E + L
Sbjct: 279 DHYQLQVQELTDLLKSK--NEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLRE 336
Query: 1054 KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK---LSADLKN 1110
KLK NA+L+ DK + AL+ +Q K LTE+++ ++ K + DLKN
Sbjct: 337 KLK--NAQLDADK----SNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKN 390
Score = 42.3 bits (95), Expect = 0.017
Identities = 144/762 (18%), Positives = 319/762 (41%), Gaps = 73/762 (9%)
Query: 189 KERERRSLSKSKED---EKTARYKDE--RSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPX 243
KE+++++LS++ + E TA ++ ++++ + + +Q R++ LK V
Sbjct: 1737 KEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNE 1796
Query: 244 XXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDIL--LRR 301
+ N+ + ++++ ++ + + + E +++E ++ ++R
Sbjct: 1797 NLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKR 1856
Query: 302 LANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE 361
L + T + S + +LQ+KV +L E +E K + + EL +
Sbjct: 1857 LTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGK 1916
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
+IE +R KL ++ + E+ L ++D F + ++ +L+
Sbjct: 1917 KWQAKIEGIRNKL--------------KEKEGEVFTLTKQLNTLKDLFAKADKEKL-TLQ 1961
Query: 422 RELEQT-IKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQ 480
R+L+ T + +VL + ++E++ ++L++ + E +L + + R++ +++L
Sbjct: 1962 RKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDIL-YMRAHQALPRDSVVEDLHL 2020
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVP-----------QPETVKVSRSSLTRG 529
+ E L+++ SK T S PS+ + Q E +K+S ++
Sbjct: 2021 QNRYLQEKLHALEKQF----SKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 2076
Query: 530 GSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANC-KQVNPPTFLDKQVMTDNIVTCD 588
E Q +DL + DL+E ++E A +++ + T +
Sbjct: 2077 FQLE---QANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKT 2133
Query: 589 IHESETVTNSIQ--NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMA 646
I + V +Q N+ + AS + EK +I++ E+ + + + + ++
Sbjct: 2134 IGLMKKVVEKVQRENEQLKKASGILTSEKM----ANIEQENEKLKAELEKLKAHLGHQLS 2189
Query: 647 ANNLRKT--AARVEEDNESLLLQLKK---MATKARSRKLSPTPPANKLSI---ETAN--- 695
+ KT ++ +NE L +LKK A K R K + K+++ ET
Sbjct: 2190 MHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQ 2249
Query: 696 --DNDEKETDEADPAEMK--LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS 751
++ + + AD K ++ + E + L + + Q LK+ VKE T +
Sbjct: 2250 FAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQK 2309
Query: 752 VTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLH-AELSLA 810
V K + + E+ +K E ++ + ++KE+ E +H E +
Sbjct: 2310 VNKYNEDLEQQIKILKHVPEGAETEQGLK-RELQVLRLANHQLDKEK-AELIHQIEANKD 2367
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE-NKKLQ 869
Q ++ I D ++ DL+ QL++ + E L+ + + L+ + E ++++
Sbjct: 2368 QSGAESTIP--DADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIE 2425
Query: 870 LLK-NAK-SLRSDKALDLNTKK-TTQLENELKEALAKIKELE 908
LK N K ++ + L+ KK + QL EL +A +E E
Sbjct: 2426 DLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFE 2467
Score = 38.3 bits (85), Expect = 0.28
Identities = 59/274 (21%), Positives = 110/274 (40%), Gaps = 17/274 (6%)
Query: 188 EKERERRSLSK---SKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXX 244
E ER R+ L K + E + A+ E + K V K + + + P + G
Sbjct: 2205 ENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSK 2264
Query: 245 XXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN 304
+++++ + I LKQ V +R ++V K D+ +
Sbjct: 2265 SWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQ---- 2320
Query: 305 IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
I G +E L++++ L N L EK L I +IE+ + + E+
Sbjct: 2321 IKILKHVPEGAETEQ-GLKRELQVLRLANHQLDKEKAEL---IHQIEANKD-QSGAESTI 2375
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
+QL+ K+ ET + E + +K+E++ L +NF +E L+
Sbjct: 2376 PDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKEL----ENFDPSFFEEIEDLKYNY 2431
Query: 425 EQTIKNCRVLSFKLKK-TERKADQLEQEKAEHEK 457
++ +K +L K+KK +E+ +L A E+
Sbjct: 2432 KEEVKKNILLEEKVKKLSEQLGVELTSPVAASEE 2465
Score = 36.3 bits (80), Expect = 1.1
Identities = 45/228 (19%), Positives = 102/228 (44%), Gaps = 28/228 (12%)
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
+D++ IK+++ +A +++ ++K LA EN Y
Sbjct: 848 EDQVQQDAIKVKEYNNLLNALQMDSDEMKKILA--ENSRKITVLQVNEKSLIRQY--TTL 903
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
EL+ L+ E +K ++ + +AE+ K+ L++ +I L++
Sbjct: 904 VELERQLRKENEK-------QKNELLSMEAEVCE---KIGCLQRFKEMAIFKIAALQKVV 953
Query: 1438 EETVKKLEHSLALEKAEYEELTGKY-ELLEEEHVVTKARLTVEKEQAQG-----ELLHVQ 1491
+ +V E L L +Y ELT KY ++L++++++ + +E + + ++ +
Sbjct: 954 DNSVSLSE--LELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESIN 1011
Query: 1492 KELSTALGEIKTLQE------KLGTESAAWNTEKTEMQNSIASLQERL 1533
KEL ++ T+++ KLG ES+ +K+ + I S+ +++
Sbjct: 1012 KELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKI 1059
Score = 36.3 bits (80), Expect = 1.1
Identities = 47/173 (27%), Positives = 83/173 (47%), Gaps = 14/173 (8%)
Query: 1394 MRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK-QEYEETVKKLEHSLALE 1451
+R+A ++ V +D L++L KLK + Q+ + ITELK +E+E +L+ + E
Sbjct: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLER-QREITELKVKEFENIKLQLQENHEDE 1679
Query: 1452 ----KAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
KAE E+L + ++E K+ L +KE + L L L+EK
Sbjct: 1680 VKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEK 1739
Query: 1508 LGTESAAWNTEKTEMQNSI-ASLQERLCGGGWEVERARLNAR--LDQRERELR 1557
+ A + E++ + A+ +ER+ + E A LN + +D+ REL+
Sbjct: 1740 ---QQKALSRALLELRAEMTAAAEERIISATSQKE-AHLNVQQIVDRHTRELK 1788
Score = 33.5 bits (73), Expect = 7.9
Identities = 41/160 (25%), Positives = 72/160 (45%), Gaps = 13/160 (8%)
Query: 1625 EITDTKTRYEGQMNTMRDELKSLHNQVS-RFRRERDNYKQMLE--AAQKSMAE-IKNGDK 1680
EI + ++E ++ D L NQ+ R+ ++N + +LE A KS+ E +K +
Sbjct: 1427 EILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKES 1486
Query: 1681 SARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRL 1740
+ R+ +I S D+ N++ L + A E E + L ++ + A +
Sbjct: 1487 ALRLAEQNILSRDK--VINELRL--RLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTI 1542
Query: 1741 AEMQSRLNEYEE-----ERLLSSGRARVAGLATRMELAWH 1775
A MQ+RLN+ EE +RLL R + + E H
Sbjct: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLH 1582
>AY517555-1|AAT44528.1| 941|Homo sapiens hypothetical
rhabdomyosarcoma antigen MU-RMS-40.3 protein.
Length = 941
Score = 72.1 bits (169), Expect = 2e-11
Identities = 193/930 (20%), Positives = 367/930 (39%), Gaps = 105/930 (11%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTAN------KYTTGRS 316
S +++ + +E ++ LR ER +++ + D+ L + + +D N + +
Sbjct: 27 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 86
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQ----TRQIE 368
E +LQ KV + T + + K L +I E+E E+E TR TE Q R++E
Sbjct: 87 FEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 146
Query: 369 QLRAKLLAAETLCEELMDENE-------DMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
+L +L A + ++ N+ ++++L + M R+ AD + L
Sbjct: 147 ELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELG 206
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQL--EQEKAEHEKKLLE-IVGGPDGMQRENRIK-- 476
+++ + + L + + + + D L E K LE I + E R K
Sbjct: 207 EQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNE 266
Query: 477 ELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS-SLTRGGSQEDP 535
E+++ ++ T RLQ E E + + + ++ + + ++ L R +E+
Sbjct: 267 EIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENK 326
Query: 536 AQ--LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE 593
A+ L LQ S LREQ +E A ++ + T I +E
Sbjct: 327 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 386
Query: 594 TVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSI--FNHMAA---- 647
+ + + + E ++ S++KT + Q + + + N +AA
Sbjct: 387 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 446
Query: 648 --NNLRKTAA----RVEEDNESLLLQLKKMATKARSR-KLSPTPPANKLSIETA-NDNDE 699
N K A + EE L LK+ + + KL +ET +N
Sbjct: 447 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 506
Query: 700 KETDEADPAEM-----KLLLELN------EQEATVLRRKVEE----LEQDKEALKKQVKE 744
E + AD E K + EL E E ++ +EE LE ++ + + E
Sbjct: 507 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 566
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI---DEVRKKLIEKERDCE 801
LT S + + A + + L N + E L+ E+ +E + + E D
Sbjct: 567 LTQVKSEIDRKIAEKDEEIEQ-LKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 625
Query: 802 RLHAELSLAQKK-PKTLIKSRS-----------LDASDQQNVDLKRQLQVIEQEASVLRA 849
+ +LS A ++ +TL RS LD + + DLK QL ++E+ A++L+A
Sbjct: 626 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 685
Query: 850 KTQSLEADNEKLQ-----TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
+ + L A E+ + E + L + + L + ++TKK +LE +L + +++
Sbjct: 686 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK--KLETDLMQLQSEV 743
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
++ ++ + + K T+A + LK +Q Q L
Sbjct: 744 EDASRDARNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 802
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEI-GEMYVVMKNAGLSGKEMTAKTKL 1023
+ A K K +I K L+ + +LE E+ GE KN S K + +
Sbjct: 803 EQLALKGGKKQIQK----------LETRIRELEFELEGEQ---KKNTE-SVKGLRKYERR 848
Query: 1024 EKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNL 1083
KE+ + KN + ++LQ ++ K + + + K++ ++E
Sbjct: 849 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHE---- 904
Query: 1084 SNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+ E E+Q+NKL A ++ TS
Sbjct: 905 ---LEEAEERADIAESQVNKLRAKTRDFTS 931
Score = 69.7 bits (163), Expect = 1e-10
Identities = 169/856 (19%), Positives = 321/856 (37%), Gaps = 70/856 (8%)
Query: 967 DAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
+ +K + + + L L+L ++ + DLE + ++ +K ++ +K + E+
Sbjct: 41 EQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQ 100
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
+ + K E L+ EI + AK E + +A + + L
Sbjct: 101 TLG---LQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGG 157
Query: 1086 QCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ 1145
T E K REA+ KL DL+ AT M + Q
Sbjct: 158 VTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQ 217
Query: 1146 VDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXX 1205
K++++K++ E+ D + + C+ +E QLS + +
Sbjct: 218 -----KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 272
Query: 1206 XXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKIT-- 1263
Q L LS +L EK+ + ++ +++ F T + E + + ENK
Sbjct: 273 SELTTQKSRLQTEAGELSRQL-EEKESIVSQLSRSKQAF-TQQTEELKRQLEEENKAKNA 330
Query: 1264 ---SLESTIAAKDVHIKQLED----------ALRQTTND------KYD-EATSPVEMVEM 1303
+L+S+ D+ +Q E+ AL + ++ KY+ +A E +E
Sbjct: 331 LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 390
Query: 1304 RXXXXXXXXXXXXXQDELNNAK-IKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
Q E NAK LEKT+ E+ L D+ + +
Sbjct: 391 AKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG---EVEDLMVDVERANSLAAALDKK 447
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN--KDA--ELATLKGKLKI 1418
+ W+ K +E +L++ K+ + K +KN ++A +L T+K + K
Sbjct: 448 QRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK-LKNAYEEALDQLETVKRENKN 506
Query: 1419 LEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
LEQ ++I E + E ++K + LEKA+ + + E E R+ +
Sbjct: 507 LEQEIADLTEQIAENGKTIHE-LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL 565
Query: 1479 EKEQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAWNTEKTEMQNSIASLQERLCG-- 1535
E Q + E+ E + ++K Q + T +A + E +N L++++ G
Sbjct: 566 ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE-VRSRNEAIRLKKKMEGDL 624
Query: 1536 GGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQR 1595
E++ + N + + + LR+ + + H D ER + + +
Sbjct: 625 NEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQ 684
Query: 1596 XXXXXXXXXXXXXXXXXXXIEQSEKARK---AEITDTKTRYE---GQMNTMRDELKSLHN 1649
+EQ+E+ARK E+ D+ R + Q ++ K L
Sbjct: 685 ----------AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET 734
Query: 1650 QVSRFRRE-RDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQV 1708
+ + + E D + A +K+ I + A + ++ E K LEQ V
Sbjct: 735 DLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK--NLEQTV 792
Query: 1709 ACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLAT 1768
L+ L E+ LA K + + + E R+ E++ L E E+++ S +
Sbjct: 793 KDLQHRLDEAEQLALKGGKKQIQK---LETRIRELEFEL-EGEQKKNTESVKGLRKYERR 848
Query: 1769 RMELAWHKERDEQQRL 1784
EL + E D + L
Sbjct: 849 VKELTYQSEEDRKNVL 864
Score = 59.7 bits (138), Expect = 1e-07
Identities = 161/914 (17%), Positives = 350/914 (38%), Gaps = 88/914 (9%)
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
KV L + K L++QV++L S + K R+ KLA+E + LE++
Sbjct: 18 KVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRK--LEGDLKLAQESILDLENDK 75
Query: 787 DEVRKKLIEKERD-CE---RLHAELSLA---QKKPKTLIK-----SRSLDA-------SD 827
++ ++L +K+ + C+ ++ E +L QKK K L ++A ++
Sbjct: 76 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 135
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
+Q D R+L+ + + T + N+K + E KL+ +L+ + +
Sbjct: 136 KQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLR 195
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
KK EL E + ++ ++ + EKSE K+ + + KSK
Sbjct: 196 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLE 255
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVM 1007
+ +SL + + K R+ + +L+ +L+ K+ + + +
Sbjct: 256 DQLSEARGKNEEIQRSLSELTTQ--KSRLQTEAGELSRQLEEKESIVS-QLSRSKQAFTQ 312
Query: 1008 KNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE-IAKLKDVNAKLEGDK 1066
+ L +++ + K + + S++D + E+ + E A+L+ +K +
Sbjct: 313 QTEELK-RQLEEENKAKNALAHALQS-SRHDCDLLREQYEEEQEGKAELQRALSKANSEV 370
Query: 1067 DVFANKYKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADL----KNATSLQTTMSDC 1121
+ KY+ L K L + +++ E Q+ ++A K LQ + D
Sbjct: 371 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL 430
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNY-TKIDQDKNKL---LKEVGDKTKKIGDXXXXX 1177
M + + TK ++ + +L LKE + ++
Sbjct: 431 MVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAY 490
Query: 1178 XXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEKDELQ 1234
+ ++++ + + L + +++ +E + +E +
Sbjct: 491 EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAE 550
Query: 1235 ARFIKTESKFITLEAEMRDLKADYENKIT---------------SLESTIAAKDVHIKQL 1279
A E+K + ++ E+ +K++ + KI ++E+ +A D ++
Sbjct: 551 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 610
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT--EAESSA 1337
+A+R + D +++ Q +L + ++ L+ E
Sbjct: 611 NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLK 670
Query: 1338 AKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWE----NKAKEL----DTDLQSERK 1389
+L + + +++L + E + E N+ +L +T L +K
Sbjct: 671 EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 730
Query: 1390 KL--DRMRIAHDKDVKNKDAELATLKGKLKILE--------QNSGAGAKRITELKQEYEE 1439
KL D M++ + + ++DA A K K I + + + + +K+ E+
Sbjct: 731 KLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 790
Query: 1440 TVKKLEHSLALEKAEYEELT-GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
TVK L+H L++AE L GK ++ + E + + +E EQ + E L
Sbjct: 791 TVKDLQH--RLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKK------NTESVKGL 842
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA--RLNARLD---QRE 1553
+ + ++L +S +Q+ + LQ ++ + E A + NA L + +
Sbjct: 843 RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQ 902
Query: 1554 RELRAANDRRDVLE 1567
EL A +R D+ E
Sbjct: 903 HELEEAEERADIAE 916
Score = 43.6 bits (98), Expect = 0.007
Identities = 83/384 (21%), Positives = 153/384 (39%), Gaps = 36/384 (9%)
Query: 1403 KNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKY 1462
++K L K KL+ ++ + ++ +L+ + E +KLE L L + +L
Sbjct: 16 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 75
Query: 1463 ELLEE-----EHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAA-WN 1516
+ L+E + + + VE EQ G L QK++ I+ L+E++ E A
Sbjct: 76 QQLDERLKKKDFEYCQLQSKVEDEQTLG--LQFQKKIKELQARIEELEEEIEAERATRAK 133
Query: 1517 TEK--TEMQNSIASLQERL-CGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXX 1573
TEK ++ + L ERL GG + LN + + +LR + L+H
Sbjct: 134 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA-TLQHEAMVA 192
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRY 1633
E++ +QR +E+ + K EI D +
Sbjct: 193 TLRKKHADSVAELGEQIDNLQR---------------VKQKLEKEKSEFKLEIDDLSSSM 237
Query: 1634 EGQMNT---MRDELKSLHNQVSRFRRERDNYKQMLE--AAQKSMAEIKNGDKSARIHRNS 1688
E + + ++L +Q+S R + + ++ L QKS + + G+ S ++
Sbjct: 238 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK- 296
Query: 1689 ISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAE-VRLAEMQSRL 1747
S + R+K A QQ L+ +L E + L L S + + +R + +
Sbjct: 297 -ESIVSQLSRSKQA-FTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQE 354
Query: 1748 NEYEEERLLSSGRARVAGLATRME 1771
+ E +R LS + VA T+ E
Sbjct: 355 GKAELQRALSKANSEVAQWRTKYE 378
Score = 37.9 bits (84), Expect = 0.37
Identities = 53/311 (17%), Positives = 134/311 (43%), Gaps = 24/311 (7%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ + + +QI + + L K +++E EK+DI L ++ A +++L+
Sbjct: 507 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA----LEEAEAALEHEEAKILR 562
Query: 322 LQQKVNELTTH-NEDLRDEKKHLTQKIREIESELETRPST-EAQTR-QIEQLRAKLLAAE 378
+Q ++ ++ + + + ++ + + Q R + +ET S +A+ R + E +R K
Sbjct: 563 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEG 622
Query: 379 TLCE---ELMDENEDMKKELRDLXXXXXXMQDN--FREDQADEYSSLRRELEQTIKNCRV 433
L E +L N + L+ L ++D +D L+ +L + +
Sbjct: 623 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL 682
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L ++++ +Q E+ + E++LL+ R++ L + +L+
Sbjct: 683 LQAEVEELRATLEQTERARKLAEQELLD---------SNERVQLLHTQNTSLIHTKKKLE 733
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG--GSQEDPAQLLRDLQDSLEREA- 550
+L + S+ ++ + ++ +++ ++D + L ++ +LE+
Sbjct: 734 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 793
Query: 551 DLREQLRNAEE 561
DL+ +L AE+
Sbjct: 794 DLQHRLDEAEQ 804
Score = 34.3 bits (75), Expect = 4.5
Identities = 32/165 (19%), Positives = 75/165 (45%), Gaps = 5/165 (3%)
Query: 1617 QSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIK 1676
Q+E+ + + TK++ E Q+ + L+ R + + L+ AQ+S+ +++
Sbjct: 13 QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLE 72
Query: 1677 NGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSA 1736
N DK R + + ++KV + + ++ E + +L E+ +E+++
Sbjct: 73 N-DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATR 131
Query: 1737 EVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQ 1781
A+ + + ++Y E S R AG T ++ +K+R+ +
Sbjct: 132 ----AKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAE 172
>AF020091-1|AAB69327.1| 622|Homo sapiens smooth muscle myosin heavy
chain SM1 protein.
Length = 622
Score = 71.7 bits (168), Expect = 2e-11
Identities = 90/453 (19%), Positives = 182/453 (40%), Gaps = 17/453 (3%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE 777
E+ L++++++L D + ++ V L K + A + + AE
Sbjct: 69 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 128
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R K E + + + L E E L + + + + L+ S+ D + +L++
Sbjct: 129 REK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSK 184
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENEL 897
+ +E + + KTQ E ++E TE+ KL+L N ++L+ DL + Q E +
Sbjct: 185 RALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEEKR 241
Query: 898 KEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXX 957
++ ++ E E +DE+ ++ + K E D LK +
Sbjct: 242 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKHVRKL 300
Query: 958 QATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEM 1017
QA +K D Q+ + + T + +K + LE ++ ++ + A + K+
Sbjct: 301 QAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ- 355
Query: 1018 TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 356 -ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 413
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ LSN+ T + E+ +L K S M +
Sbjct: 414 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEA 471
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 472 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 504
Score = 68.1 bits (159), Expect = 3e-10
Identities = 110/539 (20%), Positives = 228/539 (42%), Gaps = 38/539 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 76 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 133
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 134 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 193
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK--T 441
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + T
Sbjct: 194 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 253
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV--ARSTEVALR-LQRELAE 498
E + ++ ++ A KK LE +Q ++ IK E+ + R + ++ QREL +
Sbjct: 254 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQAQMKDFQRELED 313
Query: 499 ANSK----FTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 314 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 373
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 374 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 432
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
S++++ + + E + + S + A + + +VE++
Sbjct: 433 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 491
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 492 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 548
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKISSVTKTS-AGSNTTARRSLTTNSNKLAEE 777
L+R+++E + EA+ ++V L SK+ +TS S + R + N++ EE
Sbjct: 549 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 607
Score = 60.9 bits (141), Expect = 5e-08
Identities = 69/305 (22%), Positives = 130/305 (42%), Gaps = 20/305 (6%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
EY+ ++E +++ + +++E + D+ L+ D+A K V KLQ ++
Sbjct: 250 EYETELEDERKQRALAAAAKKKLEGDLKDLELQA----DSAIKGREEAIKHVRKLQAQMK 305
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
+ ED R + + +E E + + S EA Q+++ L AAE ++ E
Sbjct: 306 DFQRELEDARASRDEIFATAKENEKKAK---SLEADLMQLQE---DLAAAERARKQADLE 359
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
E++ +EL +QD R +A + L ELE+ N +S +++K ++A+Q
Sbjct: 360 KEELAEELASSLSGRNALQDEKRRLEA-RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 418
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQEVA---RSTEVALRLQ-RELAE 498
L E A + ++R+N ++ E+E V +ST AL + +L E
Sbjct: 419 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 478
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
+ + K + + K+ L ++ Q + R L+ QL
Sbjct: 479 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 538
Query: 559 AEEET 563
AEEE+
Sbjct: 539 AEEES 543
Score = 58.4 bits (135), Expect = 2e-07
Identities = 100/547 (18%), Positives = 217/547 (39%), Gaps = 23/547 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSE 318
++ K +Q +IE L Q+ + +++EK K+ + L + ++D + + +
Sbjct: 40 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 99
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQLRA--KLL 375
K Q + E + DE+ + RE E++ L + E E+L K+L
Sbjct: 100 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 159
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQT--IKNCRV 433
AE E+L+ +D+ K + +L ++ E+ + L EL+ T K
Sbjct: 160 KAE--MEDLVSSKDDVGKNVHELEKSKRALETQM-EEMKTQLEELEDELQATEDAKLRLE 216
Query: 434 LSFKLKKTERKAD-QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ + K + + D Q E+ E +++ L+ + E+ K+ A ++ L
Sbjct: 217 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 276
Query: 493 QRELAEANSKFTGSNPSLMKVPQPET-VKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
+ +A+S G ++ V + + +K + L + D ++ +++ ++
Sbjct: 277 KDLELQADSAIKGREEAIKHVRKLQAQMKDFQRELEDARASRD--EIFATAKENEKKAKS 334
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPS 611
L L +E+ A ++ L+K+ + + + + + + + A
Sbjct: 335 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 394
Query: 612 SKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKM 671
+E+ + D+ + TQ L A ++E N+ L +L +M
Sbjct: 395 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 454
Query: 672 ATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVL-----RR 726
+S K T A + I + E+E E A L + + + +L R+
Sbjct: 455 EGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 513
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
E+ ++ E +VK+L ++ + S N RR L ++ A E + + E+
Sbjct: 514 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN-RRKLQRELDE-ATESNEAMGREV 571
Query: 787 DEVRKKL 793
+ ++ KL
Sbjct: 572 NALKSKL 578
Score = 56.8 bits (131), Expect = 7e-07
Identities = 109/573 (19%), Positives = 225/573 (39%), Gaps = 48/573 (8%)
Query: 797 ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
ER L+ +LS ++KK + + +++A ++ +++++ + Q+ A LE
Sbjct: 13 ERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 70
Query: 857 DNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEK 915
+LQ E L + L N + L S+ L+ +K QL E K +K + + E
Sbjct: 71 TKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 128
Query: 916 SEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
EK+ + + + L++K+ L S KDD K+
Sbjct: 129 REKETKALSLARALEEALEAKEELERTNKMLKAE--------MEDLVSSKDDVGKNVH-E 179
Query: 976 IPKKPTDLTTKLQ-LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
+ K L T+++ +K +E+LE E+ ++ + + L G+ +++ +E
Sbjct: 180 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 239
Query: 1030 IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKT 1089
R +L + E+ E + + A KLEGD K LE + + +
Sbjct: 240 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-------LKDLELQADSAIKGREE 292
Query: 1090 LTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY 1149
+ ++ +AQ+ +L++A + + + +
Sbjct: 293 AIKHVRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 352
Query: 1150 TK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXX 1208
K D +K +L +E+ ++E++L + +
Sbjct: 353 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 412
Query: 1209 XXQAVVLANTHRRLSIEL-TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLES 1267
QA L+N L+ E T++K+E + ++ ++K L +++ +++ ++K +S
Sbjct: 413 TQQAEQLSN---ELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKF---KS 464
Query: 1268 TIAAKDVHIKQLEDALRQTTNDKYDEATS------PVEMVEMRXXXXXXXXXXXXXQDEL 1321
TIAA + I QLE+ + Q +K S ++ + ++ Q E
Sbjct: 465 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 524
Query: 1322 NNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
NA++K LE+ E ES +L+ +L
Sbjct: 525 GNARVKQLKRQLEEAEEESQRINANRRKLQREL 557
Score = 53.6 bits (123), Expect = 7e-06
Identities = 114/581 (19%), Positives = 231/581 (39%), Gaps = 33/581 (5%)
Query: 317 SEVLKLQQKVNE-LTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ----TRQIEQLR 371
+E ++ +Q + ++T N L D KK L +E+ E + + + T+Q E+
Sbjct: 3 NEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 62
Query: 372 AKLLAAETLCEELMDENEDMKKEL---RDLXXXXXXMQDNFREDQADE------YSSLR- 421
A E L E +D+ +L R L Q F + A+E Y+ R
Sbjct: 63 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 122
Query: 422 -RELEQTIKNCRVLSFK--LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL 478
E E K + LS L++ ++LE+ + ++ ++V D + + + EL
Sbjct: 123 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHEL 180
Query: 479 EQEVARSTEVALR-LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ 537
E+ R+ E + ++ +L E + + + +++ + E +
Sbjct: 181 EKS-KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 239
Query: 538 LLRDLQDSL-EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
R LQ L E E +L ++ R A K+ D ++ D+ + E+
Sbjct: 240 KRRQLQRQLHEYETELEDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKHV 297
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAAR 656
+Q +M S + K E+ + + + +AA + A
Sbjct: 298 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 357
Query: 657 VEEDN--ESLLLQLK-KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+E++ E L L + A + R+L + +E N E +D A +
Sbjct: 358 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 417
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
+L+ + AT R ++ E ++ L++Q KEL SK+ + + +L +
Sbjct: 418 -QLSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 475
Query: 774 LAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDL 833
L EE+V+ E K L +K++ + + ++ ++K K ++ + + + L
Sbjct: 476 L-EEQVEQEAREKQAATKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQL 532
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA 874
KRQL+ E+E+ + A + L+ + ++ N+ + NA
Sbjct: 533 KRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 573
Score = 48.8 bits (111), Expect = 2e-04
Identities = 103/575 (17%), Positives = 220/575 (38%), Gaps = 37/575 (6%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
L+I+L+ K +LQ F T LE + + + EN E AA D +++ ++
Sbjct: 19 LNIQLSDSKKKLQD-FASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYD-KLEKTKN 73
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
L+Q +D + + ++V + +++ K E+ AE+ A + E
Sbjct: 74 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYADERDRAEAEAREKE 132
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
L A LE + E+ D D+ +L++ + A +
Sbjct: 133 TKALSLARA-LEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQ 190
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
++ +L L+ +L+ E + LK ++E ++ + ++ + + +
Sbjct: 191 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 250
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
YE E+ +A K++ +G+L ++ + +A+ G E A + K
Sbjct: 251 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI---------KGREEAIKHVRK-- 299
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
+Q + Q L + +R +E E +A + D+++ D
Sbjct: 300 LQAQMKDFQREL----EDARASRDEIFATAKENEKKAKSLEADLMQLQED-LAAAERARK 354
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
+ E +++ I Q E+ E+ + + E + +R
Sbjct: 355 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE----ELEEEQGNMEAMSDRVR 410
Query: 1642 DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
+ + ER Q E+A++ + E +N + +++H + + ++++ +
Sbjct: 411 KATQQAEQLSNELATERST-AQKNESARQQL-ERQNKELRSKLH--EMEGAVKSKFKSTI 466
Query: 1702 ALLEQQVACLEDEL-CESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGR 1760
A LE ++A LE+++ E+R + + +K E+ L R + + G
Sbjct: 467 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 526
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
ARV L ++E A +E QR+ L R+L
Sbjct: 527 ARVKQLKRQLEEA----EEESQRINANRRKLQREL 557
>AF013570-1|AAB69326.1| 588|Homo sapiens smooth muscle myosin heavy
chain SM2 protein.
Length = 588
Score = 71.7 bits (168), Expect = 2e-11
Identities = 90/453 (19%), Positives = 182/453 (40%), Gaps = 17/453 (3%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE 777
E+ L++++++L D + ++ V L K + A + + AE
Sbjct: 69 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 128
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R K E + + + L E E L + + + + L+ S+ D + +L++
Sbjct: 129 REK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELEKSK 184
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENEL 897
+ +E + + KTQ E ++E TE+ KL+L N ++L+ DL + Q E +
Sbjct: 185 RALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEEKR 241
Query: 898 KEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXX 957
++ ++ E E +DE+ ++ + K E D LK +
Sbjct: 242 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKHVRKL 300
Query: 958 QATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEM 1017
QA +K D Q+ + + T + +K + LE ++ ++ + A + K+
Sbjct: 301 QAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ- 355
Query: 1018 TAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 356 -ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 413
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
+ LSN+ T + E+ +L K S M +
Sbjct: 414 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEA 471
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 472 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 504
Score = 64.1 bits (149), Expect = 5e-09
Identities = 103/510 (20%), Positives = 216/510 (42%), Gaps = 37/510 (7%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKE--KSDILLRRLANIDTANKYTTGRS---SEVLKLQQ 324
Q +++ L ++D R+ +EK+ K D LL NI ++KY R +E + +
Sbjct: 76 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI--SSKYADERDRAEAEAREKET 133
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEE 383
K L E+ + K+ L + + +++E+E S++ + + +L A ET EE
Sbjct: 134 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 193
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK--T 441
+ + E+++ EL+ ++ N + + L+ EQ + R L +L + T
Sbjct: 194 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 253
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV--ARSTEVALR-LQRELAE 498
E + ++ ++ A KK LE +Q ++ IK E+ + R + ++ QREL +
Sbjct: 254 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKHVRKLQAQMKDFQRELED 313
Query: 499 ANSK----FTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLRDLQDSLER 548
A + F + + K E ++ ++ R Q D +L +L SL
Sbjct: 314 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 373
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
L+++ R E A ++ + + M+D + ++E ++N + + A
Sbjct: 374 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELATERSTAQK 432
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
S++++ + + E + + S + A + + +VE++
Sbjct: 433 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQEAREKQAAT 491
Query: 669 KKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEAT---- 722
K + K + K L K++ + ++ E A ++K LE E+E+
Sbjct: 492 KSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAEEESQRINA 548
Query: 723 ---VLRRKVEELEQDKEALKKQVKELTSKI 749
L+R+++E + EA+ ++V L SK+
Sbjct: 549 NRRKLQRELDEATESNEAMGREVNALKSKL 578
Score = 60.9 bits (141), Expect = 5e-08
Identities = 69/305 (22%), Positives = 130/305 (42%), Gaps = 20/305 (6%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
EY+ ++E +++ + +++E + D+ L+ D+A K V KLQ ++
Sbjct: 250 EYETELEDERKQRALAAAAKKKLEGDLKDLELQA----DSAIKGREEAIKHVRKLQAQMK 305
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
+ ED R + + +E E + + S EA Q+++ L AAE ++ E
Sbjct: 306 DFQRELEDARASRDEIFATAKENEKKAK---SLEADLMQLQE---DLAAAERARKQADLE 359
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
E++ +EL +QD R +A + L ELE+ N +S +++K ++A+Q
Sbjct: 360 KEELAEELASSLSGRNALQDEKRRLEA-RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 418
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQEVA---RSTEVALRLQ-RELAE 498
L E A + ++R+N ++ E+E V +ST AL + +L E
Sbjct: 419 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 478
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
+ + K + + K+ L ++ Q + R L+ QL
Sbjct: 479 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 538
Query: 559 AEEET 563
AEEE+
Sbjct: 539 AEEES 543
Score = 58.8 bits (136), Expect = 2e-07
Identities = 119/607 (19%), Positives = 252/607 (41%), Gaps = 49/607 (8%)
Query: 349 EIESELETRPSTEAQTR----QIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXX 404
++ E+E + + E Q+ + KL + E L + + +KE+ +L
Sbjct: 1 QLNEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 60
Query: 405 MQDNFREDQADEYSSLRRELEQTI---KNCRVLSFKLKKTERKADQLEQEKAEHEKKLLE 461
+ + + + + L++EL+ + N R L L+K +RK DQL E+ K +
Sbjct: 61 KAAAYDKLEKTK-NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 119
Query: 462 IVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ---PET 518
+ RE K L +AR+ E AL + EL N L+
Sbjct: 120 ERDRAEAEAREKETKAL--SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 177
Query: 519 VKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQ 578
++ +S E+ L +L+D L+ D + +L + + + ++
Sbjct: 178 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 237
Query: 579 VMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPY 638
+ +HE ET ++++ A ++K+K ++ ++ + D
Sbjct: 238 EEKRRQLQRQLHEYET---ELEDERKQRALAAAAKKK-------LEGDLKDLELQADSAI 287
Query: 639 LSIFNHMAANNLRKTAARVEEDNESL----LLQLKKMATKARSRKLSPTPPANKLSIETA 694
A ++RK A++++ L + + AT + K + + A+ + ++
Sbjct: 288 KG--REEAIKHVRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 345
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
E+ +AD + EL E+ A+ L + L+ +K L+ ++ +L ++
Sbjct: 346 LAAAERARKQADLEKE----ELAEELASSLSGR-NALQDEKRRLEARIAQLEEELEEEQG 400
Query: 755 TSAGSNTTARRSLTTN---SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ R++ SN+LA ER ++E R++L ER + L ++L +
Sbjct: 401 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNE--SARQQL---ERQNKELRSKLHEME 455
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL 871
K+ KS ++ A + + L+ Q +EQEA +A T+SL+ ++KL+ +++
Sbjct: 456 GAVKSKFKS-TIAALEAKIAQLEEQ---VEQEAREKQAATKSLKQKDKKLKEILLQVEDE 511
Query: 872 KNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQ--DEKSEKKVRFTEATKKE 929
+ ++A + + QL+ +L+EA + + + + + ++ EA +E
Sbjct: 512 RKMAEQYKEQA-EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 570
Query: 930 TDTLKSK 936
+ LKSK
Sbjct: 571 VNALKSK 577
Score = 58.4 bits (135), Expect = 2e-07
Identities = 100/547 (18%), Positives = 217/547 (39%), Gaps = 23/547 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSE 318
++ K +Q +IE L Q+ + +++EK K+ + L + ++D + + +
Sbjct: 40 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 99
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQLRA--KLL 375
K Q + E + DE+ + RE E++ L + E E+L K+L
Sbjct: 100 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 159
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQT--IKNCRV 433
AE E+L+ +D+ K + +L ++ E+ + L EL+ T K
Sbjct: 160 KAE--MEDLVSSKDDVGKNVHELEKSKRALETQM-EEMKTQLEELEDELQATEDAKLRLE 216
Query: 434 LSFKLKKTERKAD-QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ + K + + D Q E+ E +++ L+ + E+ K+ A ++ L
Sbjct: 217 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 276
Query: 493 QRELAEANSKFTGSNPSLMKVPQPET-VKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
+ +A+S G ++ V + + +K + L + D ++ +++ ++
Sbjct: 277 KDLELQADSAIKGREEAIKHVRKLQAQMKDFQRELEDARASRD--EIFATAKENEKKAKS 334
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPS 611
L L +E+ A ++ L+K+ + + + + + + + A
Sbjct: 335 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 394
Query: 612 SKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKM 671
+E+ + D+ + TQ L A ++E N+ L +L +M
Sbjct: 395 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 454
Query: 672 ATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVL-----RR 726
+S K T A + I + E+E E A L + + + +L R+
Sbjct: 455 EGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 513
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
E+ ++ E +VK+L ++ + S N RR L ++ A E + + E+
Sbjct: 514 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN-RRKLQRELDE-ATESNEAMGREV 571
Query: 787 DEVRKKL 793
+ ++ KL
Sbjct: 572 NALKSKL 578
Score = 56.8 bits (131), Expect = 7e-07
Identities = 109/573 (19%), Positives = 225/573 (39%), Gaps = 48/573 (8%)
Query: 797 ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
ER L+ +LS ++KK + + +++A ++ +++++ + Q+ A LE
Sbjct: 13 ERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 70
Query: 857 DNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEK 915
+LQ E L + L N + L S+ L+ +K QL E K +K + + E
Sbjct: 71 TKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 128
Query: 916 SEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
EK+ + + + L++K+ L S KDD K+
Sbjct: 129 REKETKALSLARALEEALEAKEELERTNKMLKAE--------MEDLVSSKDDVGKNVH-E 179
Query: 976 IPKKPTDLTTKLQ-LKKMVEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
+ K L T+++ +K +E+LE E+ ++ + + L G+ +++ +E
Sbjct: 180 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 239
Query: 1030 IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKT 1089
R +L + E+ E + + A KLEGD K LE + + +
Sbjct: 240 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-------LKDLELQADSAIKGREE 292
Query: 1090 LTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY 1149
+ ++ +AQ+ +L++A + + + +
Sbjct: 293 AIKHVRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 352
Query: 1150 TK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXX 1208
K D +K +L +E+ ++E++L + +
Sbjct: 353 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 412
Query: 1209 XXQAVVLANTHRRLSIEL-TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLES 1267
QA L+N L+ E T++K+E + ++ ++K L +++ +++ ++K +S
Sbjct: 413 TQQAEQLSN---ELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKF---KS 464
Query: 1268 TIAAKDVHIKQLEDALRQTTNDKYDEATS------PVEMVEMRXXXXXXXXXXXXXQDEL 1321
TIAA + I QLE+ + Q +K S ++ + ++ Q E
Sbjct: 465 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 524
Query: 1322 NNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
NA++K LE+ E ES +L+ +L
Sbjct: 525 GNARVKQLKRQLEEAEEESQRINANRRKLQREL 557
Score = 53.6 bits (123), Expect = 7e-06
Identities = 114/581 (19%), Positives = 231/581 (39%), Gaps = 33/581 (5%)
Query: 317 SEVLKLQQKVNE-LTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ----TRQIEQLR 371
+E ++ +Q + ++T N L D KK L +E+ E + + + T+Q E+
Sbjct: 3 NEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 62
Query: 372 AKLLAAETLCEELMDENEDMKKEL---RDLXXXXXXMQDNFREDQADE------YSSLR- 421
A E L E +D+ +L R L Q F + A+E Y+ R
Sbjct: 63 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 122
Query: 422 -RELEQTIKNCRVLSFK--LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL 478
E E K + LS L++ ++LE+ + ++ ++V D + + + EL
Sbjct: 123 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHEL 180
Query: 479 EQEVARSTEVALR-LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ 537
E+ R+ E + ++ +L E + + + +++ + E +
Sbjct: 181 EKS-KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 239
Query: 538 LLRDLQDSL-EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
R LQ L E E +L ++ R A K+ D ++ D+ + E+
Sbjct: 240 KRRQLQRQLHEYETELEDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKHV 297
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAAR 656
+Q +M S + K E+ + + + +AA + A
Sbjct: 298 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 357
Query: 657 VEEDN--ESLLLQLK-KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+E++ E L L + A + R+L + +E N E +D A +
Sbjct: 358 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 417
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
+L+ + AT R ++ E ++ L++Q KEL SK+ + + +L +
Sbjct: 418 -QLSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 475
Query: 774 LAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDL 833
L EE+V+ E K L +K++ + + ++ ++K K ++ + + + L
Sbjct: 476 L-EEQVEQEAREKQAATKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQL 532
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA 874
KRQL+ E+E+ + A + L+ + ++ N+ + NA
Sbjct: 533 KRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 573
Score = 48.8 bits (111), Expect = 2e-04
Identities = 103/575 (17%), Positives = 220/575 (38%), Gaps = 37/575 (6%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
L+I+L+ K +LQ F T LE + + + EN E AA D +++ ++
Sbjct: 19 LNIQLSDSKKKLQD-FASTVE---ALEEGKKRFQKEIENLTQQYEEKAAAYD-KLEKTKN 73
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLE 1341
L+Q +D + + ++V + +++ K E+ AE+ A + E
Sbjct: 74 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYADERDRAEAEAREKE 132
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
L A LE + E+ D D+ +L++ + A +
Sbjct: 133 TKALSLARA-LEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNVHELEKSKRALETQ 190
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
++ +L L+ +L+ E + LK ++E ++ + ++ + + +
Sbjct: 191 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 250
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
YE E+ +A K++ +G+L ++ + +A+ G E A + K
Sbjct: 251 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI---------KGREEAIKHVRK-- 299
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
+Q + Q L + +R +E E +A + D+++ D
Sbjct: 300 LQAQMKDFQREL----EDARASRDEIFATAKENEKKAKSLEADLMQLQED-LAAAERARK 354
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
+ E +++ I Q E+ E+ + + E + +R
Sbjct: 355 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE----ELEEEQGNMEAMSDRVR 410
Query: 1642 DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
+ + ER Q E+A++ + E +N + +++H + + ++++ +
Sbjct: 411 KATQQAEQLSNELATERST-AQKNESARQQL-ERQNKELRSKLH--EMEGAVKSKFKSTI 466
Query: 1702 ALLEQQVACLEDEL-CESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGR 1760
A LE ++A LE+++ E+R + + +K E+ L R + + G
Sbjct: 467 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 526
Query: 1761 ARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
ARV L ++E A +E QR+ L R+L
Sbjct: 527 ARVKQLKRQLEEA----EEESQRINANRRKLQREL 557
Score = 46.4 bits (105), Expect = 0.001
Identities = 48/234 (20%), Positives = 105/234 (44%), Gaps = 12/234 (5%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL 343
RK+ + ++E ++ L L+ + + + +L++++ E + E + D +
Sbjct: 353 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 412
Query: 344 TQKIREIESELETRPST----EAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLX 399
TQ+ ++ +EL T ST E+ +Q+E+ +L + E + K + L
Sbjct: 413 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALE 470
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ--EKAEHEK 457
+++ E +A E + + L+Q K + + +++ + A+Q ++ EK
Sbjct: 471 AKIAQLEEQV-EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 529
Query: 458 KLL--EIVGGPDGMQREN-RIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
K L ++ + QR N ++L++E+ +TE + RE+ SK G P
Sbjct: 530 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 583
>Z22551-1|CAA80271.1| 1356|Homo sapiens 156 kDa Protein protein.
Length = 1356
Score = 71.3 bits (167), Expect = 3e-11
Identities = 184/955 (19%), Positives = 385/955 (40%), Gaps = 78/955 (8%)
Query: 638 YLSIFNHMAANNLRKTAARVEEDN-ESLLLQLKKMATKARSRKLSPTPPANKLSIE-TAN 695
Y + N + + V++ N E QLK +A R K + E A
Sbjct: 454 YARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAA 513
Query: 696 DNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE-LEQDKEALKKQVKELTSKISSVTK 754
D + A E++ L + V ++++E+ L Q E+ +K+V + S V
Sbjct: 514 QQDLQSKFVAKENEVQSL-HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD 572
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
+ + +S A+ VL +E+ +V + EK++ ++ E SLA ++
Sbjct: 573 ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKV---IAEKDKQIKQ--TEDSLASERD 627
Query: 815 KTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA 874
+ K L N LK ++Q ++ A+ A LE + + ++ K++LL+
Sbjct: 628 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE-- 685
Query: 875 KSLRSDKALDLNTKKTTQLENELKEAL-AKIKELEMICQDEKSEKKVRFTEATKKETDT- 932
+ L+ + + N + ++ N+ +AL +++++L+ + ++ ++ V E +E D
Sbjct: 686 EQLQHEIS---NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 742
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
LK+ + + SL + Q K + + + + +LKK+
Sbjct: 743 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ-DLKAKQNDQVSFASLVEELKKV 801
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQ 1049
+ + + +I + +++ E+ EK + +++ ++ E N EK +
Sbjct: 802 IHEKDGKIKSVEELLE------AELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL 855
Query: 1050 TEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK---TLTEEMKNREAQINKLSA 1106
+ +K++++ L+G ++ LE + +L+N K L EE ++ +A + +++
Sbjct: 856 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 915
Query: 1107 -DLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKI---DQDKNKLLKE 1162
+LK A+S + + + + T++ QD+NKL K
Sbjct: 916 HNLKEASSA-SQFEELEIVLKEKGNELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKS 974
Query: 1163 VGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRL 1222
++ K+ + + K +S R+ ++ AV R+
Sbjct: 975 QIEQLKQ---QNYQQASSFPPHEELLKVISEREKEISGLWNELDSLK-DAV---EHQRKK 1027
Query: 1223 SIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDA 1282
+ +L + E TE L+ ++ + + ++ ++E + AK+V +K+L
Sbjct: 1028 NNDLREKNWEAMEALASTEKM---LQDKVNKTSKERQQQVEAVE--LEAKEV-LKKLFPK 1081
Query: 1283 LRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEM 1342
+ +N Y E E +E+ + KL++ + + +LE
Sbjct: 1082 VSVPSNLSYGEWLHGFEK------KAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC 1135
Query: 1343 AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA-------KELDTDLQSERKKLDRMR 1395
+ KS LA+ E + W+ K K++ + S ++L+R+R
Sbjct: 1136 EKYKSVLAETEGILQKLQRSVEQE---ENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1192
Query: 1396 IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEY 1455
+ +KD++N E L+ +L+ E + ELK E KKL+ S + +
Sbjct: 1193 -SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN 1251
Query: 1456 EELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
EEL LL+ + T +L E+ + Q V +L A ++ +Q K+ AA
Sbjct: 1252 EEL----NLLKAQLNETLTKLRTEQNERQ----KVAGDLHKAQQSLELIQSKI--VKAAG 1301
Query: 1516 NTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHH 1570
+T T ++NS S + E LN + Q ++ L+A N + + H+
Sbjct: 1302 DT--TVIENSDVSPETE--SSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHY 1352
Score = 58.0 bits (134), Expect = 3e-07
Identities = 165/873 (18%), Positives = 360/873 (41%), Gaps = 85/873 (9%)
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNE 328
+Q++I QE ++ + ++V +E+ + + L + + ++ L+ +Q E
Sbjct: 389 FQNKIHVSYQETQQMQMKFQQV-REQMEAEIAHLKQENGILRDAVSNTTNQLESKQSA-E 446
Query: 329 LTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDEN 388
L +D LT+K +++ E + + E + QL+ +L AE EE+
Sbjct: 447 LNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE---QAATQLKVQLQEAERRWEEVQSY- 502
Query: 389 EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
++K + +Q F + +E SL +L T+ + + L +L + +
Sbjct: 503 --IRKRTAEHEAAQQDLQSKFVAKE-NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKR 559
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
++ + ++ +I+ + ++ + I++ ++A T ++ LAE K
Sbjct: 560 VNKEESLQMQVQDILEQNEALKAQ--IQQFHSQIAAQTSASV-----LAEELHKVIAEKD 612
Query: 509 SLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN-CK 567
+K + +++ R LT S+E+ + ++++ L+ E + L N + A+ +
Sbjct: 613 KQIKQTE-DSLASERDRLT---SKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 668
Query: 568 QVNPPTFL--DKQVMTDNIVTCDIH---ESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
++ ++ DK + + + +I E + N QNK + + S+ P
Sbjct: 669 KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND-QNKALKSEVQKLQTLVSEQPNKD 727
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
+ + E+ D L + L + A + EE N ++ + + + + K
Sbjct: 728 VVEQMEKCIQEKD-EKLKTVEELLETGLIQVATKEEELN-AIRTENSSLTKEVQDLKAKQ 785
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
+++S + + +K E D ++K + EL E E KV E+ + LK+++
Sbjct: 786 N---DQVSFASLVEELKKVIHEKD-GKIKSVEELLEAELL----KVANKEKTVQDLKQEI 837
Query: 743 KELTSKISSVTKTSAGS-NTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKL-------- 793
K L +I +V A + T++ N K EE++ ++ ++E K L
Sbjct: 838 KALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ 897
Query: 794 -IEKERDCERLHAELSLAQKKPKTLIKSRSLDASD----QQNVDLKRQLQVIEQEASVLR 848
+++E + + H + +AQ K + + + ++ +LKR ++++ S L
Sbjct: 898 DLQEENESLKAHVQ-EVAQHNLKEASSASQFEELEIVLKEKGNELKRLEAMLKERESDLS 956
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA-KIKEL 907
+KTQ L + +Q ENK L K+ + K + + EL + ++ + KE+
Sbjct: 957 SKTQLL----QDVQDENK---LFKS--QIEQLKQQNYQQASSFPPHEELLKVISEREKEI 1007
Query: 908 EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDD 967
+ + S K E +K+ + L+ K +T K L+D
Sbjct: 1008 SGLWNELDSLKDA--VEHQRKKNNDLREKNWEAMEALA-------------STEKMLQDK 1052
Query: 968 AQKSFKPRIPK-KPTDLTTKLQLKKMVEDLECEIGEMY-VVMKNAGLSGKEMTAKTKLEK 1025
K+ K R + + +L K LKK+ + Y + KE A T +
Sbjct: 1053 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1112
Query: 1026 EIDEIRSKLSKNDSEFT---NEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
E+ + KL + D T E + ++ +A+ + + KL+ + NK+K +E+
Sbjct: 1113 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES-- 1170
Query: 1083 LSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
K + + E ++ +L ++ K+ +L+
Sbjct: 1171 -HKTIKQMQSSFTSSEQELERLRSENKDIENLR 1202
Score = 55.2 bits (127), Expect = 2e-06
Identities = 177/1020 (17%), Positives = 386/1020 (37%), Gaps = 89/1020 (8%)
Query: 777 ERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR- 835
+ + V +D++ V ++E E +KK K +++ + + SD + K+
Sbjct: 88 DALAVEDDQVAPVPLNVVETSSSVR----ERKKKEKKQKPVLEEQVIKESDASKIPGKKV 143
Query: 836 -QLQVIEQ-----EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ V +Q EA+ + K ++ N ++KK++ L S R + AL L+ ++
Sbjct: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGS-DDQDKKVETLM-VPSKRQE-ALPLH-QE 199
Query: 890 TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKK-ETDTLKSKQXXXXXXXXXXX 948
T Q K+A +K ++ E + DE + ++ + K+
Sbjct: 200 TKQESGSGKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQV 259
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
+ ++ K++A+ FK + T + ++ + +V+ L+ + G + +K
Sbjct: 260 EGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK 319
Query: 1009 NAGLSG-----KEMTAKTKLEKEIDE----IRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+ ++ K KL + E + + + E EK R + ++KD
Sbjct: 320 KSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVMTRMKDRI 379
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
LE + +VF NK E + + + + E+M+ A + + + L++A S T
Sbjct: 380 GTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQL 439
Query: 1120 DCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXX 1179
+ Q K+ QD +L+ E+ +KT K+
Sbjct: 440 E----------------------SKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN 477
Query: 1180 XXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK 1239
+++ QL + R + + + +E L ++
Sbjct: 478 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 537
Query: 1240 TESKFITLEAEMRDLKADYENKITSLES-TIAAKDV--HIKQLEDALRQTTNDKYDEATS 1296
T LE + L + ++ ES + +D+ + L+ ++Q + + ++
Sbjct: 538 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 597
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLE--- 1353
V E+ +D L + + +L E E + LK+++ KL+
Sbjct: 598 SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALA 657
Query: 1354 NXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE-RKKLDRMRIAHDKDVKNKDAELATL 1412
N ++K + L+ LQ E K++ +I +D +NK +
Sbjct: 658 NEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND---QNKALKSEVQ 714
Query: 1413 KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL----LEEE 1468
K + + EQ + +++ + QE +E +K +E LE + T + EL E
Sbjct: 715 KLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE--LLETGLIQVATKEEELNAIRTENS 772
Query: 1469 HVVTKARLTVEKEQAQGELLHVQKELSTAL----GEIKTLQEKLGTE-SAAWNTEKT--E 1521
+ + + K+ Q + +EL + G+IK+++E L E N EKT +
Sbjct: 773 SLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQD 832
Query: 1522 MQNSIASLQERLCGGGWEVERAR---LNARLDQRERELRAANDRRDVLEHHHDXXXXXXX 1578
++ I +L+E + G ++E+A+ + +++ + + L+ ++ + ++ +
Sbjct: 833 LKQEIKALKEEI--GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 890
Query: 1579 XXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMN 1638
D + ++ + E+ E K + + K R E +
Sbjct: 891 NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKGNELK-RLEAMLK 949
Query: 1639 TMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
+L S + + E +K +E ++ + + S H + E E
Sbjct: 950 ERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS---SFPPHEELLKVISERE-- 1004
Query: 1699 NKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAE----MQSRLNEYEEER 1754
+++ L ++ L+D + R K N +L + A LA +Q ++N+ +ER
Sbjct: 1005 KEISGLWNELDSLKDAVEHQR----KKNNDLREKNWEAMEALASTEKMLQDKVNKTSKER 1060
Score = 47.6 bits (108), Expect = 5e-04
Identities = 182/943 (19%), Positives = 359/943 (38%), Gaps = 94/943 (9%)
Query: 699 EKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
EKE MK + E+E V + K+ Q+ + ++ + +++ ++ +
Sbjct: 364 EKERSNVVMTRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQ 423
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS--LAQKKPKT 816
N R +++ +N+L ++ E++++R +D RL EL+ + + +
Sbjct: 424 ENGILRDAVSNTTNQLESKQ----SAELNKLR-------QDYARLVNELTEKTGKLQQEE 472
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
+ K + A+ Q V L+ + E+ S +R +T EA + LQ +K + +S
Sbjct: 473 VQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ--SKFVAKENEVQS 530
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVR----FTEATKKETDT 932
L S K D K QLE L + + E + + ++E + +V+ EA K +
Sbjct: 531 LHS-KLTDTLVSK-QQLEQRLMQLME--SEQKRVNKEESLQMQVQDILEQNEALKAQIQQ 586
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL----TTKLQ 988
S+ +K +D+ S + R+ K +L
Sbjct: 587 FHSQIAAQTSASVLAEELHKVIAEKDKQIKQ-TEDSLASERDRLTSKEEELKDIQNMNFL 645
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKNDSEF--TNEK 1045
LK V+ L+ E + + K K+ ++++ ++S EF N++
Sbjct: 646 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 705
Query: 1046 NR-LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN----------QCKTLTEEM 1094
N+ L++E+ KL+ + ++ + +KDV K ++ ++ L Q T EE+
Sbjct: 706 NKALKSEVQKLQTLVSE-QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 764
Query: 1095 ---KNREAQINKLSADLK----NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
+ + + K DLK + S + + + +V
Sbjct: 765 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 824
Query: 1148 NYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXX 1207
N K QD L +E+ ++IG+ ++++ + K +
Sbjct: 825 NKEKTVQD---LKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAV 881
Query: 1208 XXXQAVVLANTHRRLSIELTSEKDELQA----------RFIKTESKFITLEA-------E 1250
+ LANT + L +L E + L+A + + S+F LE E
Sbjct: 882 LEEKEKDLANTGKWLQ-DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKGNE 940
Query: 1251 MRDLKADYENKITSLES-TIAAKDV--HIKQLEDALRQTTNDKYDEATSPVEMVEMRXXX 1307
++ L+A + + + L S T +DV K + + Q Y +A+S E+
Sbjct: 941 LKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI 1000
Query: 1308 XXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXX 1367
+EL++ K +E +++ + + + LA E
Sbjct: 1001 SEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKER 1060
Query: 1368 XXS-SYWENKAKELDTDL---QSERKKLDRMRIAHDKDVKNKDAELATL-KGKLKILEQN 1422
E +AKE+ L S L H + K K+ T ++K+LE
Sbjct: 1061 QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHK 1120
Query: 1423 SGAGAKRITELK---QEYEETVKKLEHSLALEKAEYEELTGKYEL-LEEEHVVTKARLT- 1477
+ T L+ ++Y+ + + E L + E+ K+++ ++E H K +
Sbjct: 1121 LKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSS 1180
Query: 1478 -VEKEQAQGELLHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQNSIASLQERL 1533
EQ L K++ E + L+ EK E + + TE E+++ + LQ++L
Sbjct: 1181 FTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKL 1240
Query: 1534 CGGGWEVERAR-----LNARLDQRERELRA-ANDRRDVLEHHH 1570
E R L A+L++ +LR N+R+ V H
Sbjct: 1241 DDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLH 1283
Score = 39.1 bits (87), Expect = 0.16
Identities = 68/337 (20%), Positives = 137/337 (40%), Gaps = 25/337 (7%)
Query: 305 IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
I K +G +E+ L+ V N DLR++ + + E L+ + + ++
Sbjct: 1000 ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE 1059
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
RQ +Q+ A L A+ + ++L + + L + +E A S
Sbjct: 1060 RQ-QQVEAVELEAKEVLKKLFPK-VSVPSNL-SYGEWLHGFEKKAKECMAGTSGS----- 1111
Query: 425 EQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR--ENRIKELEQEV 482
+ +VL KLK+ + L+ E +++ L E G +QR E + + +V
Sbjct: 1112 ----EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1167
Query: 483 ARSTEVALRLQRELAEANS---KFTGSNPSLMKVPQPET---VKVSRSSLTRGGSQEDPA 536
S + ++Q + + N + + + +++ ++ + R +
Sbjct: 1168 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1227
Query: 537 QLLRDLQDSLEREAD--LREQLRNAEEETANCKQVNPP-TFLDKQVMTDNIVTCDIHESE 593
+L +DL L+++ D E +R EE Q+N T L + V D+H+++
Sbjct: 1228 EL-KDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQ 1286
Query: 594 TVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
IQ+K++ AA + E SD P + + +ET
Sbjct: 1287 QSLELIQSKIVKAAGDTTVIENSDVSP-ETESSEKET 1322
Score = 36.3 bits (80), Expect = 1.1
Identities = 43/219 (19%), Positives = 96/219 (43%), Gaps = 17/219 (7%)
Query: 276 LKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
L + IL+K VE+E++ ++ +D ++K S +Q++ L + N+D
Sbjct: 1142 LAETEGILQKLQRSVEQEENKWKVK----VDESHKTIKQMQSSFTSSEQELERLRSENKD 1197
Query: 336 ---LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETLCEELMDENED- 390
LR E++HL ++ + E E R + + R+++ L +L + E + +NE+
Sbjct: 1198 IENLRREREHLEMELEKAEME---RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEEL 1254
Query: 391 --MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
+K +L + Q N R+ A + ++ LE + +++ T + +
Sbjct: 1255 NLLKAQLNETLTKLRTEQ-NERQKVAGDLHKAQQSLE--LIQSKIVKAAGDTTVIENSDV 1311
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTE 487
E EK+ + + Q + ++ + Q++ + E
Sbjct: 1312 SPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1350
>M21664-1|AAA36344.1| 532|Homo sapiens protein ( Human alpha-myosin
heavy chain mRNA, 3' end. ).
Length = 532
Score = 71.3 bits (167), Expect = 3e-11
Identities = 80/339 (23%), Positives = 145/339 (42%), Gaps = 22/339 (6%)
Query: 1481 EQAQGELLHVQKE---LSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGG 1537
E++Q EL QKE LST L ++K E+ + E +Q I+ L E+L GG
Sbjct: 57 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGG 116
Query: 1538 WEV-ERARLNARLDQRERELRAANDRRDV-LEHHHDXXXXXXXXXXXXXXDYER-VSKIQ 1594
V E ++ +L+ + EL++A + + LEH + ER V++
Sbjct: 117 KNVHELEKVRNQLEVEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERNVAEKD 176
Query: 1595 RXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRF 1654
++ ++R E+ K + EG +N M +L + +
Sbjct: 177 EEMEQAKRNHQRVVDSLQTSLDAETRSRN-EVLRVKKKMEGDLNEMEIQLSHANRMAAEA 235
Query: 1655 RRERDNYKQMLEAAQKSMAEI--KNGDKSARI----HRNSISSTDEEEYRNKVALLEQQV 1708
+++ + + +L+ Q + + N D I RN++ + EE R V E+
Sbjct: 236 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 295
Query: 1709 ACLEDELCES----RLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
E EL E+ +LL S+ NT L+++K + L+++QS + E +E + +A+ A
Sbjct: 296 KLAEQELIETSERVQLLHSQ-NTSLINQKKKMDADLSQLQSEVEEAVQECRNAEEKAKKA 354
Query: 1765 GL-ATRMELAWHKERDEQ---QRLLQETSTLARDLRQTL 1799
A M KE+D +R+ + +DL+ L
Sbjct: 355 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 393
Score = 65.7 bits (153), Expect = 2e-09
Identities = 86/426 (20%), Positives = 177/426 (41%), Gaps = 47/426 (11%)
Query: 688 KLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTS 747
K+ +++A + E + + ++ LE N+ +A + R V E +++ E K+ + +
Sbjct: 133 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI-ERNVAEKDEEMEQAKRNHQRVVD 191
Query: 748 KISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAEL 807
+ +TS + T +R + K+ E +++E+ +L R+ AE
Sbjct: 192 SL----QTSLDAETRSRNEVLRVKKKM--------EGDLNEMEIQLSH----ANRMAAEA 235
Query: 808 SLAQKKPKTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ--- 862
K ++L+K + D + N DLK + ++E+ ++L+A+ + L A E+ +
Sbjct: 236 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 295
Query: 863 --TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKV 920
E + ++ + + L S +N KK +++ +L + ++++E C++ + + K
Sbjct: 296 KLAEQELIETSERVQLLHSQNTSLINQKK--KMDADLSQLQSEVEEAVQECRNAEEKAKK 353
Query: 921 RFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKP 980
T+A + LK +Q Q L + A K K ++ K
Sbjct: 354 AITDAAMM-AEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK-- 410
Query: 981 TDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE 1040
L+ V +LE GE+ K S K M + KE+ + KN
Sbjct: 411 --------LEARVRELE---GELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR 459
Query: 1041 FTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQ 1100
+ N+LQ ++ K + E + +K++ +++E E E+Q
Sbjct: 460 LQDLVNKLQLKVKAYKGQAEEAEERANTNLSKFRKVQHELDEAE-------ERADIAESQ 512
Query: 1101 INKLSA 1106
+NKL A
Sbjct: 513 VNKLRA 518
Score = 48.4 bits (110), Expect = 3e-04
Identities = 54/236 (22%), Positives = 105/236 (44%), Gaps = 20/236 (8%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRL----ANIDTANKYTTGRSS 317
+ S +K+ Q Q++ + D L++ VE+ ++++L L A ++ +
Sbjct: 242 LQSLLKDTQIQLDDAVRANDDLKENIAIVER-RNNLLQAELEELRAVVEQTERSRKLAEQ 300
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
E+++ ++V L + N L ++KK + + +++SE+E + R E+ K +
Sbjct: 301 ELIETSERVQLLHSQNTSLINQKKKMDADLSQLQSEVE---EAVQECRNAEEKAKKAITD 357
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
+ E++KKE +D M+ N + D L + +K + +
Sbjct: 358 AAMMA------EELKKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK---Q 407
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L+K E + +LE E +K+ E V G + E RIKEL + + LRLQ
Sbjct: 408 LQKLEARVRELEGELEAEQKRNAESVKGM--RKSERRIKELTYQTEEDKKNLLRLQ 461
Score = 42.7 bits (96), Expect = 0.013
Identities = 82/436 (18%), Positives = 176/436 (40%), Gaps = 37/436 (8%)
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGK-------LKILEQNSGAGAKRITELKQ 1435
DL + ++ + A DK +N D LA K K L+ ++ + + + + +LK
Sbjct: 23 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 82
Query: 1436 EYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELS 1495
YEE+++ LE K EE++ E L E L + Q + E + +Q L
Sbjct: 83 AYEESLEHLETFKRENKNLQEEISDLTEQLGEGG-KNVHELEKVRNQLEVEKMELQSALE 141
Query: 1496 TALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR--LDQRE 1553
A ++ + K+ +N K E++ ++A E E+E+A+ N + +D +
Sbjct: 142 EAEASLEHEEGKILRAQLEFNQIKAEIERNVAEKDE-------EMEQAKRNHQRVVDSLQ 194
Query: 1554 RELRA-ANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
L A R +VL ++ Q+
Sbjct: 195 TSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLD 254
Query: 1613 XXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQ-MLEAAQKS 1671
+ ++ ++ + E + N ++ EL+ L V + R R +Q ++E +++
Sbjct: 255 DAVRAND-----DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER- 308
Query: 1672 MAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDE----LCESRLLASKLNT 1727
++ + ++ I++ D + +++V Q+ E++ + ++ ++A +L
Sbjct: 309 -VQLLHSQNTSLINQKKKMDADLSQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKK 367
Query: 1728 E------LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQ 1781
E L K + E + ++Q RL+E E+ L G+ ++ L R+ + EQ
Sbjct: 368 EQDTSAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGGKKQLQKLEARVRELEGELEAEQ 426
Query: 1782 QRLLQETSTLARDLRQ 1797
+R + + + R+
Sbjct: 427 KRNAESVKGMRKSERR 442
Score = 42.7 bits (96), Expect = 0.013
Identities = 70/319 (21%), Positives = 133/319 (41%), Gaps = 36/319 (11%)
Query: 267 KEYQDQIEGLKQEVDI-LRKRCE--RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+ +Q ++ L+ +D R R E RV+K+ L + AN+ +V LQ
Sbjct: 184 RNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 243
Query: 324 Q-------KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
++++ N+DL++ + ++ +++ELE + QT R++ LA
Sbjct: 244 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE-----RSRKLA 298
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
+EL++ +E ++ L N ++ + S L+ E+E+ ++ CR
Sbjct: 299 E----QELIETSERVQ-----LLHSQNTSLINQKKKMDADLSQLQSEVEEAVQECRNAEE 349
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL---RLQ 493
K KK A + +E + + + M E IK+L+ + + ++AL + Q
Sbjct: 350 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNM--EQTIKDLQHRLDEAEQIALKGGKKQ 407
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTR-----GGSQEDPAQLLR--DLQDSL 546
+ EA + + E+VK R S R ++ED LLR DL + L
Sbjct: 408 LQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVNKL 467
Query: 547 EREADLREQLRNAEEETAN 565
+ + + EE AN
Sbjct: 468 QLKVKAYKGQAEEAEERAN 486
Score = 41.9 bits (94), Expect = 0.022
Identities = 80/380 (21%), Positives = 154/380 (40%), Gaps = 39/380 (10%)
Query: 1224 IELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDAL 1283
+EL S +E +A E K + + E +KA+ E + + + + +++ D+L
Sbjct: 134 MELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERNVAEKDEEMEQAKRNHQRVVDSL 193
Query: 1284 RQTTNDKYDEATSPV---------EMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAE 1334
QT+ D + + V ++ EM Q ++ + + L+ T+ +
Sbjct: 194 -QTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 252
Query: 1335 SSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKL 1391
A LK ++A +E E K + +L SER + L
Sbjct: 253 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 312
Query: 1392 DRMRIAHDKDVKNKDAELATLKGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHS 1447
+ K DA+L+ L+ +++ Q N+ AK+ IT+ EE K+ + S
Sbjct: 313 HSQNTSLINQKKKMDADLSQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS 372
Query: 1448 LALEKAEYE-ELTGK---YELLEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTA 1497
LE+ + E T K + L E E + K +L + +GEL QK + +
Sbjct: 373 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 432
Query: 1498 LGEIKTLQEKLGTESAAWNTEKTE-----MQNSIASLQERLCGGGWEVERA--RLNARLD 1550
+ ++ + ++ + + TE+ + +Q+ + LQ ++ + E A R N L
Sbjct: 433 VKGMRKSERRI--KELTYQTEEDKKNLLRLQDLVNKLQLKVKAYKGQAEEAEERANTNLS 490
Query: 1551 ---QRERELRAANDRRDVLE 1567
+ + EL A +R D+ E
Sbjct: 491 KFRKVQHELDEAEERADIAE 510
Score = 41.1 bits (92), Expect = 0.039
Identities = 90/524 (17%), Positives = 200/524 (38%), Gaps = 38/524 (7%)
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTN---E 1044
L+K L+ EI ++ V ++ + + + K + +K + E + K ++ SE + E
Sbjct: 10 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 69
Query: 1045 KNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
L TE+ KLK+ + + F + K L+ E S+L+ Q + + E N+L
Sbjct: 70 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRNQL 129
Query: 1105 SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVG 1164
+ LQ+ + + +++ +K++ +++
Sbjct: 130 EVE---KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERNV---AEKDEEMEQAK 183
Query: 1165 DKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSI 1224
+++ D ++ + +R + + + L++ + R++
Sbjct: 184 RNHQRVVDSLQTS---------LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN-RMAA 233
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR 1284
E + LQ+ T+ I L+ +R D + I +E +++L +
Sbjct: 234 EAQKQVKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEELRAVVE 289
Query: 1285 QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQ 1344
QT + +E E R Q + +A + ++E E + + A+
Sbjct: 290 QTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQSEVEEAVQECRNAE 348
Query: 1345 LKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN 1404
K+ K S++ E K ++ ++ + +LD A +K
Sbjct: 349 EKA--KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE---AEQIALKG 403
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+L L+ +++ LE A KR E + ++K E +++ Y+ K L
Sbjct: 404 GKKQLQKLEARVRELEGELEAEQKR----NAESVKGMRKSER--RIKELTYQTEEDKKNL 457
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
L + +V K +L V+ + Q E ++ +T L + + +Q +L
Sbjct: 458 LRLQDLVNKLQLKVKAYKGQAE--EAEERANTNLSKFRKVQHEL 499
>AY264265-1|AAP20418.1| 1357|Homo sapiens kinectin variant 1 protein.
Length = 1357
Score = 71.3 bits (167), Expect = 3e-11
Identities = 183/955 (19%), Positives = 385/955 (40%), Gaps = 78/955 (8%)
Query: 638 YLSIFNHMAANNLRKTAARVEEDN-ESLLLQLKKMATKARSRKLSPTPPANKLSIE-TAN 695
Y + N + + V++ N E QLK +A R K + E A
Sbjct: 455 YARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAA 514
Query: 696 DNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE-LEQDKEALKKQVKELTSKISSVTK 754
D + A E++ L + V ++++E+ L Q E+ +K+V + S V
Sbjct: 515 QQDLQSKFVAKENEVQSL-HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD 573
Query: 755 TSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKP 814
+ + +S A+ VL +E+ +V + EK++ ++ E SLA ++
Sbjct: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKV---IAEKDKQIKQ--TEDSLASERD 628
Query: 815 KTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA 874
+ K L N LK ++Q ++ A+ A LE + + ++ K++LL+
Sbjct: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE-- 686
Query: 875 KSLRSDKALDLNTKKTTQLENELKEAL-AKIKELEMICQDEKSEKKVRFTEATKKETD-T 932
+ L+ + + N + ++ N+ +AL +++++L+ + ++ ++ V E +E D
Sbjct: 687 EQLQHEIS---NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM 992
LK+ + + SL + Q K + + + + +LKK+
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ-DLKAKQNDQVSFASLVEELKKV 802
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQ 1049
+ + + +I + +++ E+ EK + +++ ++ E N EK +
Sbjct: 803 IHEKDGKIKSVEELLE------AELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL 856
Query: 1050 TEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK---TLTEEMKNREAQINKLSA 1106
+ +K++++ L+G ++ LE + +L+N K L EE ++ +A + +++
Sbjct: 857 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 916
Query: 1107 -DLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKI---DQDKNKLLKE 1162
+LK A+S + + + + T++ QD+NKL K
Sbjct: 917 HNLKEASS-ASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK- 974
Query: 1163 VGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRL 1222
+ +++ + + K +S R+ ++ AV R+
Sbjct: 975 --SQIEQLKQQNYQQASSFPPHEELLKVISEREKEIS-GLWNELDSLKDAV---EHQRKK 1028
Query: 1223 SIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDA 1282
+ +L + E TE L+ ++ + + ++ ++E + AK+V +K+L
Sbjct: 1029 NNDLREKNWEAMEALASTEK---MLQDKVNKTSKERQQQVEAVE--LEAKEV-LKKLFPK 1082
Query: 1283 LRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEM 1342
+ +N Y E E +E+ + KL++ + + +LE
Sbjct: 1083 VSVPSNLSYGEWLHGFE------KKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC 1136
Query: 1343 AQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA-------KELDTDLQSERKKLDRMR 1395
+ KS LA+ E + W+ K K++ + S ++L+R+R
Sbjct: 1137 EKYKSVLAETEG---ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1193
Query: 1396 IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEY 1455
+ +KD++N E L+ +L+ E + ELK E KKL+ S + +
Sbjct: 1194 -SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN 1252
Query: 1456 EELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAW 1515
EEL LL+ + T +L E+ + Q V +L A ++ +Q K+ AA
Sbjct: 1253 EEL----NLLKAQLNETLTKLRTEQNERQ----KVAGDLHKAQQSLELIQSKI--VKAAG 1302
Query: 1516 NTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHH 1570
+T T ++NS S + E LN + Q ++ L+A N + + H+
Sbjct: 1303 DT--TVIENSDVSPETE--SSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHY 1353
Score = 59.3 bits (137), Expect = 1e-07
Identities = 148/810 (18%), Positives = 332/810 (40%), Gaps = 57/810 (7%)
Query: 310 KYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ 369
K +G + LK K ELTT L+ EK L ++E + + R Q E+
Sbjct: 309 KEKSGVIQDALKKSSK-GELTTLIHQLQ-EKDKLLAAVKEDAAATKDRCKQLTQEMMTEK 366
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
R+ ++ + D ++KE ++ Q ++ +R ++E I
Sbjct: 367 ERSNVVITR-----MKDRIGTLEKEHNVFQNKIHVSYQETQQMQM-KFQQVREQMEAEIA 420
Query: 430 NCRVLSFKLKKT-ERKADQLEQEKAEHEKKLLEIVGG--PDGMQRENRIKELEQEVARST 486
+ + + L+ +QLE +++ KL + + ++ ++++ E + +
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD-LQDS 545
+ A +L+ +L EA ++ S ++ E + ++ ++E+ Q L L D+
Sbjct: 481 QAATQLKVQLQEAERRWEEVQ-SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDT 539
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
L + L ++L E K+VN L QV + ++E + IQ
Sbjct: 540 LVSKQQLEQRLMQLMESEQ--KRVNKEESLQMQVQDI------LEQNEALKAQIQQFHSQ 591
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
A+ S+ ++ + K E D + +A+ R T+ EE+ + +
Sbjct: 592 IAAQTSASVLAEE----LHKVIAEK----DKQIKQTEDSLASERDRLTSK--EEELKDI- 640
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLR 725
Q KA +KL AN+ + +++ +++LL E + E +
Sbjct: 641 -QNMNFLLKAEVQKLQAL--ANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKM 697
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE 785
+ + L +ALK +V++L + +S + + +E++K +E+
Sbjct: 698 EEFKILNDQNKALKSEVQKLQTLVSE----QPNKDVVEQMEKCIQEK---DEKLKTVEEL 750
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
++ ++ KE + + E S K+ + L K++ D ++ ++ +VI ++
Sbjct: 751 LETGLIQVATKEEELNAIRTENSSLTKEVQDL-KAKQNDQVSFASL-VEELKKVIHEKDG 808
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNA-KSLRSD-------KALDLN-TKKTTQLENE 896
+++ + LEA+ K+ + K +Q LK K+L+ + KA L+ T K +L+N
Sbjct: 809 KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNL 868
Query: 897 LKEALAKIKELEMICQDEKSE--KKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
LK ++ ++ + ++++ + ++ + ++E ++LK+
Sbjct: 869 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF 928
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGL-S 1013
+ LK K++ K + + ++ +DL++K QL + V+D +K
Sbjct: 929 EELEIVLKE-KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQ 987
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+L K I E ++S +E + K+ ++ + K D+ K + A+
Sbjct: 988 ASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTE 1047
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINK 1103
K L+++ + S + + E ++ ++ K
Sbjct: 1048 KMLQDKVNKTSKERQQQVEAVELEAKEVLK 1077
Score = 56.4 bits (130), Expect = 1e-06
Identities = 176/1020 (17%), Positives = 385/1020 (37%), Gaps = 88/1020 (8%)
Query: 777 ERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR- 835
+ + V +D++ V ++E E +KK K +++ + + SD + K+
Sbjct: 88 DALAVEDDQVAPVPLNVVETSSSVR----ERKKKEKKQKPVLEEQVIKESDASKIPGKKV 143
Query: 836 -QLQVIEQ-----EASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ V +Q EA+ + K ++ N ++KK++ L S R + AL L+ +
Sbjct: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGS-DDQDKKVETLM-VPSKRQE-ALPLHQET 200
Query: 890 TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKK-ETDTLKSKQXXXXXXXXXXX 948
+ + K+A +K ++ E + DE + ++ + K+
Sbjct: 201 KQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQV 260
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
+ ++ K++A+ FK + T + ++ + +V+ L+ + G + +K
Sbjct: 261 EGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK 320
Query: 1009 NAGLSG-----KEMTAKTKLEKEIDE----IRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+ ++ K KL + E + + + E EK R I ++KD
Sbjct: 321 KSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRI 380
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
LE + +VF NK E + + + + E+M+ A + + + L++A S T
Sbjct: 381 GTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQL 440
Query: 1120 DCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXX 1179
+ Q K+ QD +L+ E+ +KT K+
Sbjct: 441 E----------------------SKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN 478
Query: 1180 XXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK 1239
+++ QL + R + + + +E L ++
Sbjct: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 538
Query: 1240 TESKFITLEAEMRDLKADYENKITSLES-TIAAKDV--HIKQLEDALRQTTNDKYDEATS 1296
T LE + L + ++ ES + +D+ + L+ ++Q + + ++
Sbjct: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLE--- 1353
V E+ +D L + + +L E E + LK+++ KL+
Sbjct: 599 SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALA 658
Query: 1354 NXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSE-RKKLDRMRIAHDKDVKNKDAELATL 1412
N ++K + L+ LQ E K++ +I +D +NK +
Sbjct: 659 NEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND---QNKALKSEVQ 715
Query: 1413 KGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL----LEEE 1468
K + + EQ + +++ + QE +E +K +E LE + T + EL E
Sbjct: 716 KLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE--LLETGLIQVATKEEELNAIRTENS 773
Query: 1469 HVVTKARLTVEKEQAQGELLHVQKELSTAL----GEIKTLQEKLGTE-SAAWNTEKT--E 1521
+ + + K+ Q + +EL + G+IK+++E L E N EKT +
Sbjct: 774 SLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQD 833
Query: 1522 MQNSIASLQERLCGGGWEVERAR---LNARLDQRERELRAANDRRDVLEHHHDXXXXXXX 1578
++ I +L+E + G ++E+A+ + +++ + + L+ ++ + ++ +
Sbjct: 834 LKQEIKALKEEI--GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891
Query: 1579 XXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMN 1638
D + ++ + E+ E K + + K R E +
Sbjct: 892 NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELK-RLEAMLK 950
Query: 1639 TMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
+L S + + E +K +E ++ + + S H + E E
Sbjct: 951 ERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS---SFPPHEELLKVISERE-- 1005
Query: 1699 NKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAE----MQSRLNEYEEER 1754
+++ L ++ L+D + R K N +L + A LA +Q ++N+ +ER
Sbjct: 1006 KEISGLWNELDSLKDAVEHQR----KKNNDLREKNWEAMEALASTEKMLQDKVNKTSKER 1061
Score = 48.0 bits (109), Expect = 3e-04
Identities = 178/943 (18%), Positives = 360/943 (38%), Gaps = 94/943 (9%)
Query: 699 EKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
EKE MK + E+E V + K+ Q+ + ++ + +++ ++ +
Sbjct: 365 EKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQ 424
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELS--LAQKKPKT 816
N R +++ +N+L ++ E++++R +D RL EL+ + + +
Sbjct: 425 ENGILRDAVSNTTNQLESKQ----SAELNKLR-------QDYARLVNELTEKTGKLQQEE 473
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
+ K + A+ Q V L+ + E+ S +R +T EA + LQ +K + +S
Sbjct: 474 VQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ--SKFVAKENEVQS 531
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVR----FTEATKKETDT 932
L S K D K QLE L + + E + + ++E + +V+ EA K +
Sbjct: 532 LHS-KLTDTLVSK-QQLEQRLMQLME--SEQKRVNKEESLQMQVQDILEQNEALKAQIQQ 587
Query: 933 LKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL----TTKLQ 988
S+ +K +D+ S + R+ K +L
Sbjct: 588 FHSQIAAQTSASVLAEELHKVIAEKDKQIKQ-TEDSLASERDRLTSKEEELKDIQNMNFL 646
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKNDSEF--TNEK 1045
LK V+ L+ E + + K K+ ++++ ++S EF N++
Sbjct: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706
Query: 1046 NR-LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN----------QCKTLTEEM 1094
N+ L++E+ KL+ + ++ + +KDV K ++ ++ L Q T EE+
Sbjct: 707 NKALKSEVQKLQTLVSE-QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
Query: 1095 ---KNREAQINKLSADLK----NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
+ + + K DLK + S + + + +V
Sbjct: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 825
Query: 1148 NYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXX 1207
N K QD L +E+ ++IG+ ++++ + K +
Sbjct: 826 NKEKTVQD---LKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAV 882
Query: 1208 XXXQAVVLANTHRRLSIELTSEKDELQA----------RFIKTESKFITLEAEMRDLKAD 1257
+ LANT + L +L E + L+A + + S+F LE +++ + +
Sbjct: 883 LEEKEKDLANTGKWLQ-DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENE 941
Query: 1258 ---YENKITSLESTIAAKDVHIKQLED-------ALRQTTNDKYDEATSPVEMVEMRXXX 1307
E + ES +++K ++ ++D + Q Y +A+S E+
Sbjct: 942 LKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI 1001
Query: 1308 XXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXX 1367
+EL++ K +E +++ + + + LA E
Sbjct: 1002 SEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKER 1061
Query: 1368 XXS-SYWENKAKELDTDL---QSERKKLDRMRIAHDKDVKNKDAELATL-KGKLKILEQN 1422
E +AKE+ L S L H + K K+ T ++K+LE
Sbjct: 1062 QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHK 1121
Query: 1423 SGAGAKRITELK---QEYEETVKKLEHSLALEKAEYEELTGKYEL-LEEEHVVTKARLT- 1477
+ T L+ ++Y+ + + E L + E+ K+++ ++E H K +
Sbjct: 1122 LKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSS 1181
Query: 1478 -VEKEQAQGELLHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQNSIASLQERL 1533
EQ L K++ E + L+ EK E + + TE E+++ + LQ++L
Sbjct: 1182 FTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKL 1241
Query: 1534 CGGGWEVERAR-----LNARLDQRERELRA-ANDRRDVLEHHH 1570
E R L A+L++ +LR N+R+ V H
Sbjct: 1242 DDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLH 1284
Score = 45.6 bits (103), Expect = 0.002
Identities = 126/627 (20%), Positives = 248/627 (39%), Gaps = 60/627 (9%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
++E ++Q V + + +E++ + ++ N SEV KLQ V+E
Sbjct: 667 ELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE--- 723
Query: 332 HNEDLRDEKKHLTQKIREIESELET-RPSTEAQTRQIEQLRAKLLAAETLCEELMDENED 390
+ +D + + + I+E + +L+T E Q+ +L A T L E +D
Sbjct: 724 --QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQD 781
Query: 391 MKKELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTI-------KNCRVLSFKLKKT 441
+K + D +++ ++ + S+ LE + K + L ++K
Sbjct: 782 LKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKAL 841
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN- 500
+ + ++ EKA+ L I +Q N +K E+++ V +++LA
Sbjct: 842 KEEIGNVQLEKAQQ----LSITSKVQELQ--NLLKGKEEQMNTMKAVLEEKEKDLANTGK 895
Query: 501 --SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER-EADLREQLR 557
N SL K E + + + E+ +L++ ++ L+R EA L+E+
Sbjct: 896 WLQDLQEENESL-KAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 954
Query: 558 NAEEETANCKQVNPPTFLDK----QVMTDNIVTCDI---HESETVTNSIQNKMIHAASTP 610
+ +T + V L K Q+ N HE S + K I
Sbjct: 955 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 1014
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFD-LPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
K D+ K + + +++ + L+ M + + KT+ ++ E++ L+ K
Sbjct: 1015 LDSLK-DAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAK 1073
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
++ K + P + LS EK+ E + +E VL K++
Sbjct: 1074 EVLKKLFPKVSVP----SNLSYGEWLHGFEKKAKEC------MAGTSGSEEVKVLEHKLK 1123
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDE--ID 787
E ++ L+ + + K SV + G +RS+ NK +VKV E I
Sbjct: 1124 EADEMHTLLQLECE----KYKSVLAETEGILQKLQRSVEQEENKW---KVKVDESHKTIK 1176
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE-QEASV 846
+++ E++ ERL +E K + L + R + + +++R V E +E
Sbjct: 1177 QMQSSFTSSEQELERLRSE----NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKD 1232
Query: 847 LRAKTQ-SLEADNEKLQTENKKLQLLK 872
L + Q L+ + +N++L LLK
Sbjct: 1233 LLTELQKKLDDSYSEAVRQNEELNLLK 1259
Score = 42.7 bits (96), Expect = 0.013
Identities = 78/387 (20%), Positives = 159/387 (41%), Gaps = 48/387 (12%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEK-------------EKSDILLRRLANIDTA 308
+ S V+E Q+ ++G +++++ ++ E EK E+++ L + +
Sbjct: 858 ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQH 917
Query: 309 NKYTTGRSSEV----LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
N +S+ + L++K NEL L++ + L+ K + ++ + ++Q
Sbjct: 918 NLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQI 977
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE- 423
Q++Q + ++ EEL+ + +KE+ L ++D E Q + + LR +
Sbjct: 978 EQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAV-EHQRKKNNDLREKN 1036
Query: 424 ---LEQTIKNCRVLSFKLKKTERKADQ----LEQEKAEHEKKLLEIVGGPDGMQR----- 471
+E ++L K+ KT ++ Q +E E E KKL V P +
Sbjct: 1037 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1096
Query: 472 --ENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ--PETVKVSRSSLT 527
E + KE + S EV + L+ +L EA+ T K ET + + L
Sbjct: 1097 GFEKKAKECMAGTSGSEEVKV-LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ-KLQ 1154
Query: 528 RGGSQE---------DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNP--PTFLD 576
R QE + + ++ +Q S E+LR+ ++ N ++ L+
Sbjct: 1155 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1214
Query: 577 KQVMTDNIVTCDIHESETVTNSIQNKM 603
K M + ++ E + + +Q K+
Sbjct: 1215 KAEMERSTYVTEVRELKDLLTELQKKL 1241
Score = 39.1 bits (87), Expect = 0.16
Identities = 68/337 (20%), Positives = 137/337 (40%), Gaps = 25/337 (7%)
Query: 305 IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
I K +G +E+ L+ V N DLR++ + + E L+ + + ++
Sbjct: 1001 ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE 1060
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
RQ +Q+ A L A+ + ++L + + L + +E A S
Sbjct: 1061 RQ-QQVEAVELEAKEVLKKLFPK-VSVPSNL-SYGEWLHGFEKKAKECMAGTSGS----- 1112
Query: 425 EQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR--ENRIKELEQEV 482
+ +VL KLK+ + L+ E +++ L E G +QR E + + +V
Sbjct: 1113 ----EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1168
Query: 483 ARSTEVALRLQRELAEANS---KFTGSNPSLMKVPQPET---VKVSRSSLTRGGSQEDPA 536
S + ++Q + + N + + + +++ ++ + R +
Sbjct: 1169 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228
Query: 537 QLLRDLQDSLEREAD--LREQLRNAEEETANCKQVNPP-TFLDKQVMTDNIVTCDIHESE 593
+L +DL L+++ D E +R EE Q+N T L + V D+H+++
Sbjct: 1229 EL-KDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQ 1287
Query: 594 TVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
IQ+K++ AA + E SD P + + +ET
Sbjct: 1288 QSLELIQSKIVKAAGDTTVIENSDVSP-ETESSEKET 1323
Score = 36.3 bits (80), Expect = 1.1
Identities = 43/219 (19%), Positives = 96/219 (43%), Gaps = 17/219 (7%)
Query: 276 LKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
L + IL+K VE+E++ ++ +D ++K S +Q++ L + N+D
Sbjct: 1143 LAETEGILQKLQRSVEQEENKWKVK----VDESHKTIKQMQSSFTSSEQELERLRSENKD 1198
Query: 336 ---LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETLCEELMDENED- 390
LR E++HL ++ + E E R + + R+++ L +L + E + +NE+
Sbjct: 1199 IENLRREREHLEMELEKAEME---RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEEL 1255
Query: 391 --MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
+K +L + Q N R+ A + ++ LE + +++ T + +
Sbjct: 1256 NLLKAQLNETLTKLRTEQ-NERQKVAGDLHKAQQSLE--LIQSKIVKAAGDTTVIENSDV 1312
Query: 449 EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTE 487
E EK+ + + Q + ++ + Q++ + E
Sbjct: 1313 SPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1351
>AB053469-1|BAC54108.1| 720|Homo sapiens ELKS gamma protein.
Length = 720
Score = 71.3 bits (167), Expect = 3e-11
Identities = 80/388 (20%), Positives = 182/388 (46%), Gaps = 25/388 (6%)
Query: 687 NKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELT 746
NK + + + +EK T + ++K +L++ E++ VL++K+E L++ +KQ+ L
Sbjct: 239 NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK 298
Query: 747 SKISSVTKTSAGSNTTARRSLTTNSNKLAE-----ERVKVLEDEIDEVRKKLIEK-ERDC 800
++ S+ + ++T +LTT LAE ER+K D + +++ I+ ++D
Sbjct: 299 ERVKSLQADTTNTDT----ALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDL 354
Query: 801 ERLHAELSLAQ----KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
+ L ++SL Q +K +L+ + AS + LK+ ++ E ++ + K + L+
Sbjct: 355 KDLKEKVSLLQGDLSEKEASLLDLKE-HASSLASSGLKKDSRLKTLEIALEQKKEECLKM 413
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
+++ + L+ A SD+ L ++ T+ ++E +A A++ L I ++ ++
Sbjct: 414 ESQLKKAHEAALE--ARASPEMSDRIQHLE-REITRYKDESSKAQAEVDRLLEILKEVEN 470
Query: 917 EKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRI 976
EK + + E ++L S+Q ++ + ++A++ + +
Sbjct: 471 EKNDK--DKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSA--QMLEEARRR-EDNL 525
Query: 977 PKKPTDLTTKLQLK-KMVEDLECEIGE-MYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKL 1034
L L+ K +E+LE + E + + + + +E +A+T EK+++E+ +
Sbjct: 526 NDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAM 585
Query: 1035 SKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
K E + K +L + L + L
Sbjct: 586 EKVKQELESMKAKLSSTQQSLAEKETHL 613
Score = 58.8 bits (136), Expect = 2e-07
Identities = 125/592 (21%), Positives = 246/592 (41%), Gaps = 74/592 (12%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKS------------DILLRRLANIDTANK 310
D+ + + Q Q++ + +E D+LRK E E + S ++ R D A+K
Sbjct: 148 DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK 207
Query: 311 YTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQL 370
T + E ++ Q+ N++ L +++ L +K ++I+ E + + Q +I L
Sbjct: 208 ITIWK--EQYRVVQEENQVDALRLRLEEKETMLNKKTKQIQDMAEEKGT---QAGEIHDL 262
Query: 371 RAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN 430
+ L E L + E+++++LRD +++ + QAD T
Sbjct: 263 KDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQAD--------TTNTDTA 314
Query: 431 CRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL 490
L L + ER ++L++++ E++ E + D +++ +K+L+++V+
Sbjct: 315 LTTLEEALAEKERTIERLKEQRDRDEREKQEEI---DNYKKD--LKDLKEKVS------- 362
Query: 491 RLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
LQ +L+E + SL+ +K SSL G ++D L+ L+ +LE++
Sbjct: 363 LLQGDLSEKEA-------SLL------DLKEHASSLASSGLKKD--SRLKTLEIALEQKK 407
Query: 551 D----LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHA 606
+ + QL+ A E + P D+ + +T ES + +
Sbjct: 408 EECLKMESQLKKAHEAALEARA--SPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEIL 465
Query: 607 ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
+ K D ++ T Q ++ H +K+A +EE
Sbjct: 466 KEVENEKNDKDKKIAELESLTSR-QVKDQNKKVANLKHKEQVEKKKSAQMLEE------A 518
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
+ ++ S++L + IE + + EM L E E T +
Sbjct: 519 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE--ESARTNAEK 576
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
+VEEL E +K++++ + +K+SS T+ S T +L K EE VLE +
Sbjct: 577 QVEELLMAMEKVKQELESMKAKLSS-TQQSLAEKETHLTNLRAERRKHLEE---VLEMKQ 632
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
+ + + EK+ + L ELS ++KK + + + + D+ LK+Q Q
Sbjct: 633 EALLAAISEKDANIALL--ELSSSKKKTQEEVAALKRE-KDRLVQQLKQQTQ 681
Score = 46.4 bits (105), Expect = 0.001
Identities = 70/380 (18%), Positives = 144/380 (37%), Gaps = 30/380 (7%)
Query: 1188 EKQLSTRKDRVTXXXXXXXXXXXQAVVL--ANTHRRLSIELTSEKDELQARFIKTESKFI 1245
EKQ+S+ K+RV L A + +IE E+ + R + E
Sbjct: 291 EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE---- 346
Query: 1246 TLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRX 1305
++ +DLK D + K++ L+ ++ K+ + L+ E S + ++
Sbjct: 347 -IDNYKKDLK-DLKEKVSLLQGDLSEKEASLLDLK------------EHASSLASSGLKK 392
Query: 1306 XXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD-LAKLENXXXXXXXXXX 1364
Q + K++ + +A +A + + SD + LE
Sbjct: 393 DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS 452
Query: 1365 XXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSG 1424
KE++ + + KK+ + + VK+++ ++A LK K ++ ++ S
Sbjct: 453 KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSA 512
Query: 1425 AGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ 1484
+ + ++ ++L+ SL + EEL EE + ++T E+E
Sbjct: 513 QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL--------EEALRESVQITAEREMVL 564
Query: 1485 GELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERAR 1544
+ + + E+ EK+ E + + + Q S+A + L E R
Sbjct: 565 AQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE-RRKH 623
Query: 1545 LNARLDQRERELRAANDRRD 1564
L L+ ++ L AA +D
Sbjct: 624 LEEVLEMKQEALLAAISEKD 643
Score = 43.6 bits (98), Expect = 0.007
Identities = 63/282 (22%), Positives = 125/282 (44%), Gaps = 36/282 (12%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDT-ANKYTTGRSSEVL 320
++ + Y+D+ + EVD L + + VE EK+D +++A +++ ++ ++ +V
Sbjct: 440 LEREITRYKDESSKAQAEVDRLLEILKEVENEKND-KDKKIAELESLTSRQVKDQNKKVA 498
Query: 321 KLQQK-----------VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ 369
L+ K + E ++L D + L +R+ + +E ++ QI
Sbjct: 499 NLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITA 558
Query: 370 LRAKLLA--------AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
R +LA AE EEL+ E +K+EL + Q + E + ++LR
Sbjct: 559 EREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET-HLTNLR 617
Query: 422 RELEQTIKNCRVLSFKLKK-----TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
E + ++ VL K + +E+ A+ E + +KK E V ++RE
Sbjct: 618 AERRKHLE--EVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVA---ALKREK--D 670
Query: 477 ELEQEVARSTEVALRLQRELAEANS-KFTGSNPSLMKVPQPE 517
L Q++ + T+ ++L + E + K + SN + K P P+
Sbjct: 671 RLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHK-PSPD 711
Score = 41.5 bits (93), Expect = 0.030
Identities = 68/380 (17%), Positives = 147/380 (38%), Gaps = 29/380 (7%)
Query: 1157 NKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLA 1216
N L K++ + +++ D K ++ + +T L
Sbjct: 274 NVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 333
Query: 1217 NTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA---DYENKITSLESTIAAKD 1273
R E E D + + K L+ ++ + +A D + +SL S+ KD
Sbjct: 334 EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 393
Query: 1274 VHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEA 1333
+K LE AL Q K +E ++ D + + + ++ + +
Sbjct: 394 SRLKTLEIALEQ----KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD 449
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
ESS A+ E+ +L L ++EN +S ++ + KK+
Sbjct: 450 ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTS----------RQVKDQNKKVAN 499
Query: 1394 MRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKA 1453
++ H + V+ K + A + + + E N ++++ + ++ ++ +++LE +L
Sbjct: 500 LK--HKEQVEKKKS--AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEAL----R 551
Query: 1454 EYEELTGKYE--LLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
E ++T + E L +EE T A VE+ E V++EL + ++ + Q+ L +
Sbjct: 552 ESVQITAEREMVLAQEESARTNAEKQVEELLMAME--KVKQELESMKAKLSSTQQSLAEK 609
Query: 1512 SAAWNTEKTEMQNSIASLQE 1531
+ E + + + E
Sbjct: 610 ETHLTNLRAERRKHLEEVLE 629
Score = 38.3 bits (85), Expect = 0.28
Identities = 78/391 (19%), Positives = 154/391 (39%), Gaps = 30/391 (7%)
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+ +E +T L + K++ M A +K + E+ LK L + E+ K+I L++
Sbjct: 230 RLEEKETMLNKKTKQIQDM--AEEKGTQA--GEIHDLKDMLDVKERKVNVLQKKIENLQE 285
Query: 1436 EYEETVKKLEHSLALEKAEYEELTGKYELLE--EEHVVTKARLTVE--KEQAQGELLHVQ 1491
+ + K++ K+ + T L EE + K R T+E KEQ + Q
Sbjct: 286 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKER-TIERLKEQRDRDEREKQ 344
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
+E+ ++K L+EK+ + + +E + S+ L+E + ++RL
Sbjct: 345 EEIDNYKKDLKDLKEKV----SLLQGDLSEKEASLLDLKEH--ASSLASSGLKKDSRLKT 398
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E L + +E +R+ ++R
Sbjct: 399 LEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEV 458
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMNTMR---DELKSLHNQVSRFRRERDNYKQMLEAA 1668
+E ++ + K E + T R D+ K + N + + E+ QMLE A
Sbjct: 459 DRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 518
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTD------EEEYRNKVAL-LEQQVACLEDELCESRLL 1721
++ E D S ++ ++S+ D EE R V + E+++ ++E +R
Sbjct: 519 RR--REDNLNDSSQQL-QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEE--SARTN 573
Query: 1722 ASKLNTELVSEKSSAEVRLAEMQSRLNEYEE 1752
A K EL+ + L M+++L+ ++
Sbjct: 574 AEKQVEELLMAMEKVKQELESMKAKLSSTQQ 604
>U63139-1|AAB07119.1| 1312|Homo sapiens Rad50 protein.
Length = 1312
Score = 70.9 bits (166), Expect = 4e-11
Identities = 156/868 (17%), Positives = 356/868 (41%), Gaps = 55/868 (6%)
Query: 263 DSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKSDILL---RRLANIDTANKYTTGRSSE 318
+S ++E +++ +G ++++ L +R +EK L+ R L ++ ++ SE
Sbjct: 286 NSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSE 345
Query: 319 VLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQL-RAKLL 375
+L Q ++ + H E +R + ++E + E P +E Q + +L R +
Sbjct: 346 LLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE 405
Query: 376 AAETLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR 432
+LM+ E E +K++ D E +++ S + EL KN +
Sbjct: 406 GEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNEL----KNVK 461
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
+L+ + + +L+QE + E++L + + + + L+ E A +L
Sbjct: 462 YELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKL 521
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+E+ + N T + + + + + K + + ++ LL + + E L
Sbjct: 522 DQEMEQLN-HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWL 580
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
+ + + ++N +Q N + ++ E +S ++K+ +
Sbjct: 581 HSKSKEINQTRDRLAKLNKELASSEQ--NKNHINNELKRKEEQLSSYEDKLFDVCGSQDF 638
Query: 613 KEKSDSPPLSIDKTTEETQF--HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ D I+K++++ Y + N ++ V + +L++
Sbjct: 639 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDEN--QSCCPVCQRVFQTEAELQE 696
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDE-ADPAEMK-LLLELNEQEATVLRRKV 728
+ + +S KL P K S E+ EK DE M+ +++L E+E LR K+
Sbjct: 697 VISDLQS-KLRLAPDKLK-STESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 754
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
+ + +D + LK ++E + + ++ +A+ LT + ER ++ E+ +
Sbjct: 755 QNVNRDIQRLKNDIEEQETLLGTIMP----EEESAKVCLT---DVTIMERFQM---ELKD 804
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
V +K+ ++ + + + ++ Q + K LD + ++L R+L + +Q+ +
Sbjct: 805 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK-IELNRKL-IQDQQEQIQH 862
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
K+ + E +EKLQ L+ + L ++ ++L+T + L E+K+A ++ LE
Sbjct: 863 LKSTTNELKSEKLQISTN----LQRRQQL-EEQTVELST-EVQSLYREIKDAKEQVSPLE 916
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ + EK+ E K+ + K Q + ++ KDD
Sbjct: 917 TTLEKFQQEKE----ELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY 972
Query: 969 QKSFKPRIPKKPTDLT-TKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE--K 1025
+K + + K L+ + +K+ ED+ ++ +T + + E K
Sbjct: 973 KKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK 1032
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
E++E R + K + + ++++E KL++ ++ + ++ + K E E +
Sbjct: 1033 EVEEERKQHLKEMGQM--QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKK 1090
Query: 1086 QCKT---LTEEMKNREAQINKLSADLKN 1110
+ + E K RE I + +L N
Sbjct: 1091 ELREPQFRDAEEKYREMMIVMRTTELVN 1118
Score = 63.3 bits (147), Expect = 9e-09
Identities = 168/886 (18%), Positives = 333/886 (37%), Gaps = 82/886 (9%)
Query: 277 KQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDL 336
K E L R + + L + A ID + G S VL N + H ED
Sbjct: 108 KTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLN-----NVIFCHQEDS 162
Query: 337 R---DEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKK 393
E K L QK EI S + E RQ+ Q + + + + + + + ++
Sbjct: 163 NWPLSEGKALKQKFDEIFSATRYIKALET-LRQVRQTQGQKVKEYQMELKYLKQYKEKAC 221
Query: 394 ELRDLXXXXXXMQDNFRE------DQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
E+RD + +E ++ D + +E+E + L ++K + + Q
Sbjct: 222 EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQ 281
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAEAN--SKFT 504
+E++ +E E+K+ ++ G D ++ N + Q R E L REL + N S+
Sbjct: 282 MEKDNSELEEKMEKVFQGTD--EQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLL 339
Query: 505 GSNPSLMKVPQPE-TVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLEREADLREQLRN---- 558
S + V Q ++ R L L+ D ER Q++N
Sbjct: 340 NQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL 399
Query: 559 -AEEETANCKQVNP--PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
E + K N F +K+ + + +I + +T I S ++ K
Sbjct: 400 VRERQEGEAKTANQLMNDFAEKETLKQKQID-EIRDKKTGLGRIIELKSEILSKKQNELK 458
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
+ L + + + D + ++ ++ E + LQ +K
Sbjct: 459 NVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLK--MEVISLQNEKADLDR 516
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLELNEQEATVLR---RKVEEL 731
RKL T + D+AD E ++ + + E T L ++L
Sbjct: 517 TLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQL 576
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
E + K++ + +++ + K A S ++ N K EE++ ED++ +V
Sbjct: 577 EDWLHSKSKEINQTRDRLAKLNKELASSE--QNKNHINNELKRKEEQLSSYEDKLFDVCG 634
Query: 792 KLIEKERDCERLHAELSLAQKK-----PKTLIKSRSLDASDQQN----------VDLKRQ 836
+ E D +RL E+ + K+ T + S+ + +N + +
Sbjct: 635 SQ-DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE 693
Query: 837 LQ-VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
LQ VI S LR L++ +L+ + K+ + +R +DL K+ +L N
Sbjct: 694 LQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMR-QSIIDLKEKEIPELRN 752
Query: 896 ELKEALAKIKELEMICQD----------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXX 945
+L+ I+ L+ ++ E+ KV T+ T E ++ K
Sbjct: 753 KLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKD---VERKI 809
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEMY 1004
T++ + + Q+ K +++K++L +K+++D + +I +
Sbjct: 810 AQQAAKLQGIDLDRTVQQVNQEKQEK-----QHKLDTVSSKIELNRKLIQDQQEQI--QH 862
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ L +++ T L++ R +L + E + E L EI K+ + LE
Sbjct: 863 LKSTTNELKSEKLQISTNLQR-----RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLET 917
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
+ F + + L N+ + + + ++K + I+ D++N
Sbjct: 918 TLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIEN 963
Score = 46.8 bits (106), Expect = 8e-04
Identities = 79/406 (19%), Positives = 160/406 (39%), Gaps = 23/406 (5%)
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS-LTT 769
KL+ E E EA + + + + + +KQ+ E+ K KT G + L+
Sbjct: 398 KLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDK-----KTGLGRIIELKSEILSK 452
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
N+L + VK +++ +++E +++ + ELS A+K + + +
Sbjct: 453 KQNEL--KNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 510
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL--NT 887
DL R L+ ++QE L T + + + K + ++ KS SD+ L
Sbjct: 511 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYF 570
Query: 888 KKTTQLENELKEALAKIKELEMICQD-EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
QLE+ L +K KE+ K K++ +E K + ++
Sbjct: 571 PNKKQLEDWLH---SKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYED 627
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPR-IPKKPTDLTTKLQLKKMVEDLECEIGEMYV 1005
++ L LK++ +KS K R + T + ++ + E+ C V
Sbjct: 628 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 687
Query: 1006 VMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
A L ++KL D KL +SE +K + + E+ L + +
Sbjct: 688 FQTEAELQEVISDLQSKLRLAPD----KLKSTESEL-KKKEKRRDEMLGLVPMRQSI--- 739
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
D+ + L N+ N++ + L +++ +E + + + ++A
Sbjct: 740 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 785
Score = 45.6 bits (103), Expect = 0.002
Identities = 105/600 (17%), Positives = 236/600 (39%), Gaps = 39/600 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
N K+ +D + +E++ R R ++ KE L N + N + ++ +
Sbjct: 572 NKKQLEDWLHSKSKEINQTRDRLAKLNKE----LASSEQNKNHINNELKRKEEQLSSYED 627
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLAAETLCEE 383
K+ ++ ++D + L ++I + + A Q I QL + + +C+
Sbjct: 628 KLFDVCG-SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQR 686
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSFKLKKTE 442
+ ++++ + DL D + +++ + RR+ + R LK E
Sbjct: 687 VFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLK--E 744
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL--EQEVARS--TEVAL--RLQREL 496
++ +L + + + + D ++E + + E+E A+ T+V + R Q EL
Sbjct: 745 KEIPELRNKLQNVNRDIQRLKN--DIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL 802
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL-REQ 555
+ K L + TV+ QE +L D++ + +L R+
Sbjct: 803 KDVERKIAQQAAKLQGIDLDRTVQQVNQE-----KQEKQHKL-----DTVSSKIELNRKL 852
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
+++ +E+ + K +K ++ N+ E +TV S + + ++ +KE+
Sbjct: 853 IQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYR-EIKDAKEQ 911
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
+++K +E + + S N +A + L +V+ + + +
Sbjct: 912 VSPLETTLEKFQQEKEELINKKNTS--NKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK 969
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE------QEATVLRRKVE 729
K NK+ + + KE D M+ ++ + Q+ LR++ E
Sbjct: 970 DDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNE 1029
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
EL++ +E K+ +KE+ ++ + S ++ LA R K E+EI
Sbjct: 1030 ELKEVEEERKQHLKEM-GQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHF 1088
Query: 790 RKKLIEKE-RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
+K+L E + RD E + E+ + + + + K + +K +E+ ++R
Sbjct: 1089 KKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIR 1148
>AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein.
Length = 1302
Score = 70.9 bits (166), Expect = 4e-11
Identities = 121/626 (19%), Positives = 263/626 (42%), Gaps = 36/626 (5%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLA 376
EV +LQ+++ + +++++E++ + + E+ S+ + + +Q +E+ +L
Sbjct: 622 EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 681
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
++ E E + E+RDL M D + E +E+ ++ + L
Sbjct: 682 NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQD 741
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
L E + D L K E E L+ + + + +L+++ + ALR E
Sbjct: 742 LLIAKEGREDLL--RKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ-ALRESVEE 798
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
A N + S + + Q T R L QE+ +L ++ R A L+ Q+
Sbjct: 799 ATKNVEVLASRSNTSEQDQAGT--EMRVKLL----QEENEKLQGRSEELERRVAQLQRQI 852
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT--NSIQNKMIHAASTPSSKE 614
+ + + A K+ + + + + +V E E V+ +++N+ + A S+
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE-LEGAQGNLSQT 911
Query: 615 KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
+ LS +K EE++ L L +L KT +++++ +++ + +T
Sbjct: 912 TQEQKQLS-EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD-IVEASRTSTL 969
Query: 675 ARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-----LELNEQEATVLRRKVE 729
+L N+ + +++T EA+ + + + + L E+E +R +
Sbjct: 970 ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRLMEEELRDYQRAQD 1029
Query: 730 ELEQDKEALKKQVKELTSKI----------SSVTKTSAGSNTTARRSL--TTNSNKLAEE 777
E ++ L++ +K+L ++ S + K + L N++ L E
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEAKVSQLEMELEEERNNSDLLSE 1089
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R+ ++++++R L+++ + L +++ K L KSR + + +
Sbjct: 1090 RISRSREQMEQLRNGLLQERAARQDLECGKISLERQNKDL-KSRIIHLEGSYRSSKEGLV 1148
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAKSLRSDKALDLNTKKTTQLENE 896
+E + L + +S E D LQ N++L+ +K D+ L L +K QL
Sbjct: 1149 VQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQK-DQLSLR 1207
Query: 897 LKEALAKIKEL-EMICQDEKSEKKVR 921
LK +++E E I + E S+KK++
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQ 1233
Score = 66.1 bits (154), Expect = 1e-09
Identities = 149/782 (19%), Positives = 309/782 (39%), Gaps = 59/782 (7%)
Query: 143 DLDTGQTTNGSQTQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKED 202
++ T T Q + A T DS A+++ ++ + ++ + P + K ++ + ++E
Sbjct: 496 EVKTATATLMLQNRAAATSPDSGAKKI-SVKTFPSASNTQATPDLLKGQQELTQQTNEET 554
Query: 203 EKTARYK-------DERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXX 255
K Y D +TK VN + + K + +G
Sbjct: 555 AKQILYNYLKEGSTDNDDATKRKVNLVFE-KIQTLKSRAAGSAQGNNQACNSTSEVKDLL 613
Query: 256 XXXXXLVDSNVKEYQDQIE-GLKQEVDILRKRCERVEKEKSDILLRRLANID---TANKY 311
L V E Q Q++ +K + +I +R ER+ ++ + ++ T +
Sbjct: 614 EQKSKLT-IEVAELQRQLQLEVKNQQNIKEER-ERMRANLEELRSQHNEKVEENSTLQQR 671
Query: 312 TTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQI---E 368
E+ K +++ ++ E + E + L ++ E+ EL++ +E + + E
Sbjct: 672 LEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEE 731
Query: 369 QLRAK-----LLAAETLCEELMDENED----MKKELRDLXXXXXXMQDNFREDQADEYSS 419
L+AK LL A+ E+L+ + E +K L++ D +E E +
Sbjct: 732 LLQAKQDLQDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-----ENR 474
LR +E+ KN VL+ + +E+ E +++ ++ G + ++R + +
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
I++L+ + A++ E + + E+ + + + + +G +
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEGAQGNLSQT 911
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET 594
Q + L + L+ E++ +EQLR + E N + T Q +IV S T
Sbjct: 912 -TQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA----SRT 966
Query: 595 VTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTA 654
T +QN++ KEK+ + + +E + L+ L +
Sbjct: 967 STLELQNQL------DEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRLMEEE 1020
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL 714
R + + L +++ + + L + + + E + EM+L
Sbjct: 1021 LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEA-KVSQLEMELEE 1079
Query: 715 ELNEQEATVLR--RKVEELEQDKEAL-KKQVKELTSKISSVTKTSAGSNTTARRSLTTNS 771
E N + R R E++EQ + L +++ + ++ + +R S
Sbjct: 1080 ERNNSDLLSERISRSREQMEQLRNGLLQERAARQDLECGKISLERQNKDLKSRIIHLEGS 1139
Query: 772 NKLAEERVKV-LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI-----KSRSL-D 824
+ ++E + V +E I E+ +L +ERD L ++K K L+ + SL D
Sbjct: 1140 YRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199
Query: 825 ASDQQNVDLK---RQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA--KSLRS 879
DQ ++ LK RQ++ E+E L + + L+ + E+ N+ LQ N+ K LR
Sbjct: 1200 QKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRL 1259
Query: 880 DK 881
K
Sbjct: 1260 KK 1261
Score = 64.9 bits (151), Expect = 3e-09
Identities = 123/664 (18%), Positives = 272/664 (40%), Gaps = 52/664 (7%)
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
E + L+R+L+ +KN + + ++ ER LE+ +++H +K+ E + R+
Sbjct: 622 EVAELQRQLQLEVKNQQNIK---EERERMRANLEELRSQHNEKVEE------NSTLQQRL 672
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSS-LTRGGSQED 534
+E E E+ ++ E +++ E + ++ L ++ E RS +G E+
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM-HDELDSAKRSEDREKGALIEE 731
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNI---VTCDIHE 591
Q +DLQD L + + LR E E K D + ++
Sbjct: 732 LLQAKQDLQDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 592 -SETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF----HFDLPYLSIFNHMA 646
E+V + +N + A+ + +S++ + + EE + +L
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 647 ANNLRKTAARVEED---NESLLLQLKKMATKARSRKLSPTPPANKLS--IETANDNDEKE 701
+L+ A+ +E E + QL++ AR + L +E A N +
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEGAQGNLSQT 911
Query: 702 TDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
T E KL E ++E LRR E+E ++ L K +++L +++ + + S
Sbjct: 912 TQEQKQLSEKLKEESEQKEQ--LRRLKNEMENERWHLGKTIEKLQKEMADIVEAS----- 964
Query: 762 TARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSR 821
R S N+L E + K E+ E++++L EK + E+ ++ + L++
Sbjct: 965 --RTSTLELQNQLDEYKEKNRR-ELAEMQRQLKEKTLEAEKSRLT-AMKMQDGMRLMEEE 1020
Query: 822 SLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
D Q+ L ++ Q++EQ L+ LEA + L+ + +L AK + +
Sbjct: 1021 LRDYQRAQDEALTKR-QLLEQ---TLKDLEYELEAKSH-LKDDRSRLVKQMEAKVSQLEM 1075
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXX 941
L+ + L + + ++++L E++ ++ E K
Sbjct: 1076 ELEEERNNSDLLSERISRSREQMEQLRNGLLQERAARQDLECGKISLERQNKDLKSRIIH 1135
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+A + L+D + + R + + +L++ V++L ++
Sbjct: 1136 LEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQ----LSNRRLERKVKELVMQVD 1191
Query: 1002 EMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
+ ++ + + +++ + K ++++++E ++ + +S K +LQ E+ + D+N
Sbjct: 1192 DEHLSLTD---QKDQLSLRLKAMKRQVEEAEEEIDRLESS----KKKLQRELEEQMDMNE 1244
Query: 1061 KLEG 1064
L+G
Sbjct: 1245 HLQG 1248
Score = 57.2 bits (132), Expect = 6e-07
Identities = 120/634 (18%), Positives = 257/634 (40%), Gaps = 45/634 (7%)
Query: 676 RSRKLSPTPPANKLSIET-ANDNDEKETDEADPAEMKLLLELNEQEAT-VLRRKVEELEQ 733
R+ SP A K+S++T + ++ + T + + +L + NE+ A +L ++E
Sbjct: 509 RAAATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGST 568
Query: 734 DKE-ALKKQVKELTSKISSVTKTSAGS---NTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
D + A K++V + KI ++ +AGS N A S T+ L E++ K L E+ E+
Sbjct: 569 DNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS-TSEVKDLLEQKSK-LTIEVAEL 626
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
+++L + ++ + + E + + L + ++N L+++L+ E E
Sbjct: 627 QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKV--EENSTLQQRLEESEGELRKNLE 684
Query: 850 KTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEM 909
+ ++ + E+ QTE + LQ + D A ++ L EL +A +++L
Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL-- 742
Query: 910 ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
+ E E +R K+E + K A L++L++ +
Sbjct: 743 LIAKEGREDLLR-----KRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVE 797
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
++ K + + T Q + E+ + +N L G+ +LE+ + +
Sbjct: 798 EATK-NVEVLASRSNTSEQ-----DQAGTEMRVKLLQEENEKLQGRS----EELERRVAQ 847
Query: 1030 IRSKLS--KNDSEFTNEK-NRLQTEIAKLKD--VNAKLEGDKDVFANKYKALENENSNLS 1084
++ ++ K D E + + EI +L++ V+A+ E + V A + ALENE
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR--ALENELEGAQ 905
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD--CMXXXXXXXXXXXXXXXXXXXX 1142
T+E K ++ + S + L+ M +
Sbjct: 906 GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965
Query: 1143 XXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXX 1202
++ ++D+ K K +E+ + +++ + +++ + ++ +
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDGMRLMEEELRDYQ 1025
Query: 1203 XXXXXXXXQAVVLANTHRRLSIELTSE---KDELQARFIK-TESKFITLEAEMRDLKADY 1258
+ +L T + L EL ++ KD+ ++R +K E+K LE E+ + +
Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD-RSRLVKQMEAKVSQLEMELEEER--- 1081
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
N L I+ ++QL + L Q + D
Sbjct: 1082 -NNSDLLSERISRSREQMEQLRNGLLQERAARQD 1114
Score = 56.4 bits (130), Expect = 1e-06
Identities = 106/584 (18%), Positives = 230/584 (39%), Gaps = 24/584 (4%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+ +++ QDQ+ + E+D ++ +R + + LL+ ++ GR + K +
Sbjct: 698 TEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEGREDLLRKRE 757
Query: 324 QKVNELT-THNEDLRDEKKHLTQKIREIESELET-RPSTEAQTRQIEQLRAK-------L 374
+++ L E++ + + + + ++EL+ R S E T+ +E L ++
Sbjct: 758 RELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQ 817
Query: 375 LAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
E + L +ENE ++ +L +Q + + DE + + L++ R L
Sbjct: 818 AGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE-AKAKETLKKYEGEIRQL 876
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGG-PDGMQRENRIKELEQEVARSTEVALRLQ 493
L ++ + + E +L G Q + ++ E +E + E RL+
Sbjct: 877 EEALVHARKEEKEAVSARRALENELEGAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLK 936
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
E+ E G ++ + V+ SR+S +Q D + ++ ++ E + L+
Sbjct: 937 NEM-ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYK-EKNRRELAEMQRQLK 994
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN--KMIHAASTPS 611
E+ AE+ ++ L ++ + D D E+ T ++ K +
Sbjct: 995 EKTLEAEKSRLTAMKMQDGMRLMEEELRDYQRAQD--EALTKRQLLEQTLKDLEYELEAK 1052
Query: 612 SKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKM 671
S K D L + +Q +L + + + + ++ ++E+ LLQ +
Sbjct: 1053 SHLKDDRSRLVKQMEAKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNG-LLQERAA 1111
Query: 672 ATKARSRKLSPTPPANKLSIETAN-DNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
K+S L + + + + E +M+ + E R
Sbjct: 1112 RQDLECGKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRAN 1171
Query: 731 LEQDKEALKKQVKELTSKISS--VTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
L+ L+++VKEL ++ ++ T + R + AEE + LE +
Sbjct: 1172 LQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKK 1231
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIK--SRSLDASDQQN 830
++++L E+ E L +L+ + KK L K S+ LD D +
Sbjct: 1232 LQRELEEQMDMNEHLQGQLN-SMKKDLRLKKLPSKVLDDMDDDD 1274
Score = 52.0 bits (119), Expect = 2e-05
Identities = 96/492 (19%), Positives = 193/492 (39%), Gaps = 35/492 (7%)
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
+QL+ ++ N K + + E+R Q L ++ +L K E
Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 687
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
K+E Q ++++ L++ K ++ LQ+++ D +
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED--REKGALIEELLQAKQDLQDLLIA 745
Query: 1397 AHDKD--VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAE 1454
++ ++ ++ EL LKG LK + + + + +LK++Y+ ++ L S+
Sbjct: 746 KEGREDLLRKRERELTALKGALK---EEVSSHDQEMDKLKEQYDAELQALRESVEEATKN 802
Query: 1455 YEELTGKYELLEEEHVVTKAR---LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTE 1511
E L + E++ T+ R L E E+ QG +++ ++ +I+ L+ G E
Sbjct: 803 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLK---GDE 859
Query: 1512 SAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHD 1571
+ A T K + + I L+E L ++AR +++E + A + LE
Sbjct: 860 AKAKETLK-KYEGEIRQLEEAL-----------VHARKEEKE-AVSARRALENELEGAQG 906
Query: 1572 XXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKT 1631
+ S+ + IE+ +K A+I +
Sbjct: 907 NLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQK-EMADIVEASR 965
Query: 1632 RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISS 1691
++ DE K N+ +R ++ LEA + + +K D R+ +
Sbjct: 966 TSTLELQNQLDEYKE-KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD-GMRLMEEELRD 1023
Query: 1692 TD--EEEYRNKVALLEQQVACLEDEL-CESRLL--ASKLNTELVSEKSSAEVRLAEMQSR 1746
++E K LLEQ + LE EL +S L S+L ++ ++ S E+ L E ++
Sbjct: 1024 YQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEAKVSQLEMELEEERNN 1083
Query: 1747 LNEYEEERLLSS 1758
++ ER+ S
Sbjct: 1084 -SDLLSERISRS 1094
Score = 44.8 bits (101), Expect = 0.003
Identities = 83/441 (18%), Positives = 177/441 (40%), Gaps = 39/441 (8%)
Query: 1370 SSYWENKAKELDTDLQSERKKLDRMRIA---HDKDVKNKDAELATLKGKL----KILEQN 1422
+S + + +E + +L+ ++L ++++ H ++++ +L+ + +L + ++
Sbjct: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDRE 724
Query: 1423 SGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQ 1482
GA + + + KQ+ ++ + E L + ELT L+EE + KEQ
Sbjct: 725 KGALIEELLQAKQDLQDLLIAKEGREDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 784
Query: 1483 AQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER 1542
EL +++ + A ++ L + T + TEM+ + LQE E
Sbjct: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQ--DQAGTEMR--VKLLQE---------EN 831
Query: 1543 ARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXX 1602
+L R ++ ER R A +R + + D YE +
Sbjct: 832 EKLQGRSEELER--RVAQLQRQIEDLKGD-----EAKAKETLKKYEGEIRQLEEALVHAR 884
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
+E + + ++ T T+ + Q++ E Q+ R + E +N +
Sbjct: 885 KEEKEAVSARRALENELEGAQGNLSQT-TQEQKQLSEKLKEESEQKEQLRRLKNEMENER 943
Query: 1663 ----QMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES 1718
+ +E QK MA+I +++ + + +E+ R ++A +++Q+ E +S
Sbjct: 944 WHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 1003
Query: 1719 RLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKER 1778
RL A K+ + E L + Q +E +R L + L +E H +
Sbjct: 1004 RLTAMKMQDGM----RLMEEELRDYQRAQDEALTKRQLL--EQTLKDLEYELEAKSHL-K 1056
Query: 1779 DEQQRLLQETSTLARDLRQTL 1799
D++ RL+++ L L
Sbjct: 1057 DDRSRLVKQMEAKVSQLEMEL 1077
Score = 34.7 bits (76), Expect = 3.4
Identities = 42/235 (17%), Positives = 105/235 (44%), Gaps = 18/235 (7%)
Query: 261 LVDSNVKEYQDQIEG---LKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSS 317
L++ +K+ + ++E LK + L K+ E + L N D ++ +
Sbjct: 1037 LLEQTLKDLEYELEAKSHLKDDRSRLVKQMEAKVSQLEMELEEERNNSDLLSERISRSRE 1096
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
++ +L+ + + +DL K L ++ ++++S + + +++ ++
Sbjct: 1097 QMEQLRNGLLQERAARQDLECGKISLERQNKDLKSRIIHLEGSYRSSKE-----GLVVQM 1151
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFRE---DQADEYSSLRRELEQTIKNCRVL 434
E EL D E +++ +L ++ +E DE+ SL + +Q + +
Sbjct: 1152 EARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAM 1211
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLE-------IVGGPDGMQRENRIKELEQEV 482
++++ E + D+LE K + +++L E + G + M+++ R+K+L +V
Sbjct: 1212 KRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKV 1266
>AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein
protein.
Length = 1331
Score = 70.9 bits (166), Expect = 4e-11
Identities = 120/611 (19%), Positives = 262/611 (42%), Gaps = 44/611 (7%)
Query: 339 EKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDL 398
+++ + K E+ E + + E + ++E L+++L+A + +E + ++ E +L
Sbjct: 707 QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 766
Query: 399 XXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKK 458
+ E D L +E+ + C+ L + KK ++ +LE++ E E
Sbjct: 767 RARLTAKKQELEEICHD----LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 822
Query: 459 LLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPET 518
++ + + E ++K+LE+E+ V L QR+ A K L+ + +
Sbjct: 823 RQKLQ--LEKVTTEAKLKKLEEELD-DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 879
Query: 519 VKVS----RSSLTRGGSQEDPAQLLRDLQDSLEREADLR---EQLRNAEEETANCKQVNP 571
K + R+ + L R L++++E++A+L +Q R E+ + K +
Sbjct: 880 AKYAGERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKD-DV 938
Query: 572 PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQ 631
+ + + + + E +T ++ ++ +T +K + L ++ + Q
Sbjct: 939 GKSVHELEKSKRALEQQVEEMKTQLEELEGEL---QATEDAKLR-----LEVNLQAMKAQ 990
Query: 632 FHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSI 691
F DL + L + +E + E Q + MA AR +KL + I
Sbjct: 991 FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ-RSMAVAAR-KKLEMDLKDLEAHI 1048
Query: 692 ETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS 751
++AN N ++ + + ++ + E + T R+ E L Q KE KK +K + +++
Sbjct: 1049 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE-EILAQAKENEKK-LKSMEAEMIQ 1106
Query: 752 VTKTSAGSNTTARRS----------LTTNSNK--LAEERVKVLEDEIDEVRKKLIEKERD 799
+ + A + R++ + +S K LA E + LE I ++ ++L E++ +
Sbjct: 1107 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1166
Query: 800 CERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE 859
E ++ L A + + +L+ S Q + RQ +E++ L+ K Q +E
Sbjct: 1167 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ--LERQNKELKVKLQEMEGT-- 1222
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK 919
++++ K AK + ++ LD TK+ +++ K+K++ + DE+ +
Sbjct: 1223 -VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE 1281
Query: 920 VRFTEATKKET 930
+A K T
Sbjct: 1282 QYKDQADKAST 1292
Score = 61.7 bits (143), Expect = 3e-08
Identities = 126/599 (21%), Positives = 252/599 (42%), Gaps = 57/599 (9%)
Query: 538 LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
LL+ + E A E ++ E++ A ++ L Q+M + + + ++ET
Sbjct: 701 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 760
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
+ ++ A + K++ + ++ EE + +L N+++ ++
Sbjct: 761 AEAEEL--RARLTAKKQELEEICHDLEARVEEEEERCQ--HLQAEKKKMQQNIQELEEQL 816
Query: 658 EEDNESLL-LQLKKMATKARSRKLSPTPPANKLSIETAND---NDEKETDEADP--AEMK 711
EE+ + LQL+K+ T+A+ +KL + ++ N EK+ + D AE K
Sbjct: 817 EEEESARQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEK 876
Query: 712 LLL-------ELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
+ + E EA K L + E +Q EL +++ +T +++
Sbjct: 877 TISAKYAGERDRAEAEAREKETKALSLARALEEAMEQKAEL-ERLNKQFRTEMEDLMSSK 935
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCE-----RLHAELSLAQKKPKTLIK 819
+ + ++L E+ + LE +++E++ +L E E + + +L E++L K +
Sbjct: 936 DDVGKSVHEL-EKSKRALEQQVEEMKTQLEELEGELQATEDAKLRLEVNLQAMKAQF--- 991
Query: 820 SRSLDASDQQNVDLKRQL--QVIEQEASVL--RAKTQSLEADNEKLQTENKKLQLLKNAK 875
R L D+Q+ + K+QL QV E EA + R + A +KL+ + K L+ ++
Sbjct: 992 ERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1051
Query: 876 SLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
+ D+A+ K+ +L+ ++K+ + +EL+ D ++ ++ +A + E LKS
Sbjct: 1052 NKNRDEAI----KQLRKLQAQMKDCM---RELD----DTRASREEILAQAKENEKK-LKS 1099
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED 995
+ Q L D+ S K L K +L+ +
Sbjct: 1100 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG----KGALALEEKRRLEARIAQ 1155
Query: 996 LECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKL 1055
LE E+ E N L + K +ID+I + L+ S +N Q +
Sbjct: 1156 LEEELEEE---QGNTELINDRLK---KANLQIDQINTDLNLERSHAQKNENARQQLERQN 1209
Query: 1056 KDVNAKLEGDKDVFANKYK----ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
K++ KL+ + +KYK ALE + + L Q T+E + Q+ + LK+
Sbjct: 1210 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKD 1268
Score = 60.9 bits (141), Expect = 5e-08
Identities = 68/318 (21%), Positives = 141/318 (44%), Gaps = 22/318 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERV--EKEKSDILLRRL-ANIDTANKYTTGRSSEVLKLQ 323
K+ Q+ ++ E++ RK+ ++K ++ L+ L A+ID+ANK ++ KLQ
Sbjct: 1007 KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1066
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
++ + +D R ++ + + +E E +L+ S EA ++ QL+ +L AAE +
Sbjct: 1067 AQMKDCMRELDDTRASREEILAQAKENEKKLK---SMEA---EMIQLQEELAAAERAKRQ 1120
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
E +++ E+ + + R +A + L ELE+ N +++ +LKK
Sbjct: 1121 AQQERDELADEIANSSGKGALALEEKRRLEA-RIAQLEEELEEEQGNTELINDRLKKANL 1179
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQEVARSTEVAL-RLQRELA 497
+ DQ+ + + ++R+N +++E+E V + ++ L+ ++A
Sbjct: 1180 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1239
Query: 498 EANSKFTGSNPSLMKVPQP--ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE-READLRE 554
+ + + T K + L + + A+ +D D R L+
Sbjct: 1240 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1299
Query: 555 QLRNAEEETANCKQVNPP 572
QL AEEE ++ PP
Sbjct: 1300 QLEEAEEE---AQRATPP 1314
Score = 59.3 bits (137), Expect = 1e-07
Identities = 104/561 (18%), Positives = 205/561 (36%), Gaps = 30/561 (5%)
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK 1074
+++ A+T+L E +E+R++L+ E + L+ + + ++ L+ +K +
Sbjct: 751 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 810
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA-TSLQTTMSDCMXXXXXXXXXXX 1133
LE + + + L E EA++ KL +L + L
Sbjct: 811 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFDQ 870
Query: 1134 XXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLST 1193
+ + + + KE K + +R+ KQ T
Sbjct: 871 LLAEEKTISAKYAGERDRAEAEARE--KET--KALSLARALEEAMEQKAELERLNKQFRT 926
Query: 1194 RKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRD 1253
+ + + + E+ ++ +EL+ TE + LE ++
Sbjct: 927 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEGELQATEDAKLRLEVNLQA 986
Query: 1254 LKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXX 1313
+KA +E + + K KQL +R+ + DE V R
Sbjct: 987 MKAQFERDLQGRDEQSEEKK---KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1043
Query: 1314 XXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYW 1373
D N + EA KL+ AQ+K + +L++
Sbjct: 1044 LEAHIDSANK-----NRDEAIKQLRKLQ-AQMKDCMRELDDTRASREEILAQAKEN---- 1093
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL 1433
E K K ++ ++ +++L A + + +D ELA + +SG GA + E
Sbjct: 1094 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERD-ELA------DEIANSSGKGALALEE- 1145
Query: 1434 KQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKE 1493
K+ E + +LE L E+ E + + + + L +E+ AQ + + +++
Sbjct: 1146 KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQ-KNENARQQ 1204
Query: 1494 LSTALGEIKT-LQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
L E+K LQE GT + + T ++ IA L+E+L E + A R ++
Sbjct: 1205 LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1264
Query: 1553 ERE--LRAANDRRDVLEHHHD 1571
+ + L +D R E + D
Sbjct: 1265 KLKDVLLQVDDERRNAEQYKD 1285
Score = 48.8 bits (111), Expect = 2e-04
Identities = 79/339 (23%), Positives = 142/339 (41%), Gaps = 37/339 (10%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTG--RSSEVLKLQQ 324
K+++ ++E L D + K +EK K L +++ + T + G +++E KL+
Sbjct: 922 KQFRTEMEDLMSSKDDVGKSVHELEKSKR-ALEQQVEEMKTQLEELEGELQATEDAKLRL 980
Query: 325 KVN----------ELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAK 373
+VN +L +E ++KK L +++RE+E+ELE R ++L
Sbjct: 981 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1040
Query: 374 LLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQA--DEYSSLRRELEQTIKNC 431
L E + ++ K+LR L + +A +E + +E E+ +K+
Sbjct: 1041 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1100
Query: 432 RV----LSFKLKKTERKADQLEQEKAEHEKKLLEIVG-GPDGMQR----ENRIKELEQEV 482
L +L ER Q +QE+ E ++ G G ++ E RI +LE+E+
Sbjct: 1101 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1160
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLTRGGS------QEDP 535
+ L +AN + N L ++ + + +R L R QE
Sbjct: 1161 EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEME 1220
Query: 536 AQLLRDLQDSL----EREADLREQLRN-AEEETANCKQV 569
+ + S+ + A L EQL N +E A CKQV
Sbjct: 1221 GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1259
Score = 47.2 bits (107), Expect = 6e-04
Identities = 102/585 (17%), Positives = 224/585 (38%), Gaps = 51/585 (8%)
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLED 1281
L +L +EK +LQ + ++ E++ L AE +L+A K LE + +++ E+
Sbjct: 738 LQSQLMAEKLQLQEQ-LQAETE---LCAEAEELRARLTAKKQELEEICHDLEARVEEEEE 793
Query: 1282 ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL- 1340
+ +K + E+ E ++E K++LEK E+ KL
Sbjct: 794 RCQHLQAEKKKMQQNIQELEEQ------------LEEEESARQKLQLEKVTTEAKLKKLE 841
Query: 1341 -EMAQLKSDL-------AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLD 1392
E+ L DL LE S+ + + + + + + K
Sbjct: 842 EELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAGERDRAEAEAREKETKAL 901
Query: 1393 RMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEK 1452
+ A ++ ++ K AEL L + + ++ + + + E E++ + LE + K
Sbjct: 902 SLARALEEAMEQK-AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 960
Query: 1453 AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELL-------HVQKELSTALGEIKT-L 1504
+ EEL G+ + E+ + + L K Q + +L +K+L + E++ L
Sbjct: 961 TQLEELEGELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1020
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA-----RLNARLDQRERELRAA 1559
+++ S A K +++ + L+ + + A +L A++ REL
Sbjct: 1021 EDERKQRSMAVAARK-KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 1079
Query: 1560 N-DRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXX-------XXXXXXXXXXX 1611
R ++L + E ++ +R
Sbjct: 1080 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKG 1139
Query: 1612 XXXIEQSEK--ARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQ 1669
+E+ + AR A++ + +G + D LK + Q+ + + + + + +
Sbjct: 1140 ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE 1199
Query: 1670 KSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDEL-CESRLLASKLNTE 1728
+ +++ +K ++ + T + +Y+ + LE ++A LE++L E++ +
Sbjct: 1200 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1259
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELA 1773
+EK +V L R N + + R+ L ++E A
Sbjct: 1260 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1304
Score = 45.2 bits (102), Expect = 0.002
Identities = 132/668 (19%), Positives = 263/668 (39%), Gaps = 82/668 (12%)
Query: 709 EMKLLLELNEQEATVLRRKVE--ELEQDKEALKKQVKELTSKISSVT--KTSAGSNTTAR 764
++K LL+++ QE ++ ++ E ++ + + A + ++ E+ + S + K A
Sbjct: 697 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 756
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEV----RKKLIEKERDCERLHAELSLAQKKPKTLIKS 820
L + +L R+ + E++E+ ++ E+E C+ L AE +KK
Sbjct: 757 TELCAEAEEL-RARLTAKKQELEEICHDLEARVEEEEERCQHLQAE----KKKM------ 805
Query: 821 RSLDASDQQNV-DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS 879
QQN+ +L+ QL+ E+E++ R K Q EK+ TE K +L + L
Sbjct: 806 -------QQNIQELEEQLE--EEESA--RQKLQL-----EKVTTEAKLKKLEEELDDLLV 849
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQX- 938
D LD + LE + K+ + E + I E+ EA +KET L +
Sbjct: 850 D--LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAGERDRAEAEAREKETKALSLARAL 907
Query: 939 -XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE 997
L S KDD KS + K +K L++ VE+++
Sbjct: 908 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH-ELEK------SKRALEQQVEEMK 960
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKN----DSEFTNEKNRLQTEIA 1053
++ E+ L E AK +LE + ++++ ++ D + +K +L +
Sbjct: 961 TQLEEL-----EGELQATE-DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL---VR 1011
Query: 1054 KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNRE---AQINKLSADLKN 1110
+++++ A+LE ++ + A + +L + + KNR+ Q+ KL A +K+
Sbjct: 1012 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1071
Query: 1111 A-TSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKK 1169
L T + + ++ K + +E + +
Sbjct: 1072 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1131
Query: 1170 IGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSE 1229
I + +R+E +++ ++ + + +++ +L E
Sbjct: 1132 IANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1191
Query: 1230 KDELQARFIKTESKFITLEAEMRDLKA---DYENKITS-LESTIAAKDVHIKQLEDALRQ 1285
+ Q K E+ LE + ++LK + E + S +++I A + I QLE+ L
Sbjct: 1192 RSHAQ----KNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN 1247
Query: 1286 TTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQL 1345
T ++ A V E + DE NA E+ + ++ A + QL
Sbjct: 1248 ETKER-QAACKQVRRTEKK-----LKDVLLQVDDERRNA----EQYKDQADKASTRLKQL 1297
Query: 1346 KSDLAKLE 1353
K L + E
Sbjct: 1298 KRQLEEAE 1305
Score = 40.7 bits (91), Expect = 0.052
Identities = 86/433 (19%), Positives = 169/433 (39%), Gaps = 51/433 (11%)
Query: 1381 DTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEET 1440
+ ++ ++ ++L ++R +N+ E+ TL+ +L + + TEL E EE
Sbjct: 708 EEEMMAKEEELVKVR-EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE- 765
Query: 1441 VKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELS----- 1495
L L +K E EE+ E EE L EK++ Q + ++++L
Sbjct: 766 ---LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 822
Query: 1496 ---------TALGEIKTLQEKLG--------TESAAWNTEKTEMQNSIASLQERLCGGGW 1538
T ++K L+E+L +A N EK + + +E+ +
Sbjct: 823 RQKLQLEKVTTEAKLKKLEEELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 882
Query: 1539 EVERARLNARLDQRE-------RELRAANDRRDVLEHHHDXXXXXXXXXXXXXXD----Y 1587
ER R A ++E R L A +++ LE + D
Sbjct: 883 AGERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 942
Query: 1588 ERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKAR---KAEITDTKTRYE----GQMNTM 1640
+ K +R ++ +E A+ + + K ++E G+
Sbjct: 943 HELEKSKRALEQQVEEMKTQLEELEGELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1002
Query: 1641 RDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNK 1700
++ K L QV E ++ ++ A + +++ K H +S + +E +
Sbjct: 1003 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1062
Query: 1701 VALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGR 1760
L Q C+ EL ++R AS+ E++++ E +L M++ + + +EE L ++ R
Sbjct: 1063 RKLQAQMKDCMR-ELDDTR--ASR--EEILAQAKENEKKLKSMEAEMIQLQEE-LAAAER 1116
Query: 1761 ARVAGLATRMELA 1773
A+ R ELA
Sbjct: 1117 AKRQAQQERDELA 1129
>AF057300-1|AAD50326.1| 1173|Homo sapiens truncated RAD50 protein
protein.
Length = 1173
Score = 70.9 bits (166), Expect = 4e-11
Identities = 156/868 (17%), Positives = 356/868 (41%), Gaps = 55/868 (6%)
Query: 263 DSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKSDILL---RRLANIDTANKYTTGRSSE 318
+S ++E +++ +G ++++ L +R +EK L+ R L ++ ++ SE
Sbjct: 147 NSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSE 206
Query: 319 VLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQL-RAKLL 375
+L Q ++ + H E +R + ++E + E P +E Q + +L R +
Sbjct: 207 LLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE 266
Query: 376 AAETLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR 432
+LM+ E E +K++ D E +++ S + EL KN +
Sbjct: 267 GEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNEL----KNVK 322
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
+L+ + + +L+QE + E++L + + + + L+ E A +L
Sbjct: 323 YELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKL 382
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+E+ + N T + + + + + K + + ++ LL + + E L
Sbjct: 383 DQEMEQLN-HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWL 441
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
+ + + ++N +Q N + ++ E +S ++K+ +
Sbjct: 442 HSKSKEINQTRDRLAKLNKELASSEQ--NKNHINNELKRKEEQLSSYEDKLFDVCGSQDF 499
Query: 613 KEKSDSPPLSIDKTTEETQF--HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ D I+K++++ Y + N ++ V + +L++
Sbjct: 500 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDEN--QSCCPVCQRVFQTEAELQE 557
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDE-ADPAEMK-LLLELNEQEATVLRRKV 728
+ + +S KL P K S E+ EK DE M+ +++L E+E LR K+
Sbjct: 558 VISDLQS-KLRLAPDKLK-STESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 615
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
+ + +D + LK ++E + + ++ +A+ LT + ER ++ E+ +
Sbjct: 616 QNVNRDIQRLKNDIEEQETLLGTIMP----EEESAKVCLT---DVTIMERFQM---ELKD 665
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
V +K+ ++ + + + ++ Q + K LD + ++L R+L + +Q+ +
Sbjct: 666 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK-IELNRKL-IQDQQEQIQH 723
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
K+ + E +EKLQ L+ + L ++ ++L+T + L E+K+A ++ LE
Sbjct: 724 LKSTTNELKSEKLQISTN----LQRRQQL-EEQTVELST-EVQSLYREIKDAKEQVSPLE 777
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ + EK+ E K+ + K Q + ++ KDD
Sbjct: 778 TTLEKFQQEKE----ELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY 833
Query: 969 QKSFKPRIPKKPTDLT-TKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE--K 1025
+K + + K L+ + +K+ ED+ ++ +T + + E K
Sbjct: 834 KKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK 893
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
E++E R + K + + ++++E KL++ ++ + ++ + K E E +
Sbjct: 894 EVEEERKQHLKEMGQM--QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKK 951
Query: 1086 QCKT---LTEEMKNREAQINKLSADLKN 1110
+ + E K RE I + +L N
Sbjct: 952 ELREPQFRDAEEKYREMMIVMRTTELVN 979
Score = 61.7 bits (143), Expect = 3e-08
Identities = 156/836 (18%), Positives = 317/836 (37%), Gaps = 77/836 (9%)
Query: 327 NELTTHNEDLR---DEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
N + H ED E K L QK EI S + E RQ+ Q + + + + +
Sbjct: 14 NVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALET-LRQVRQTQGQKVKEYQMELK 72
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFRE------DQADEYSSLRRELEQTIKNCRVLSFK 437
+ + ++ E+RD + +E ++ D + +E+E + L +
Sbjct: 73 YLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNE 132
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQREL 496
+K + + Q+E++ +E E+K+ ++ G D ++ N + Q R E L REL
Sbjct: 133 IKALDSRKKQMEKDNSELEEKMEKVFQGTD--EQLNDLYHNHQRTVREKERKLVDCHREL 190
Query: 497 AEAN--SKFTGSNPSLMKVPQPE-TVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLEREADL 552
+ N S+ S + V Q ++ R L L+ D ER
Sbjct: 191 EKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFS 250
Query: 553 REQLRN-----AEEETANCKQVNP--PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
Q++N E + K N F +K+ + + +I + +T I
Sbjct: 251 ERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQID-EIRDKKTGLGRIIELKSE 309
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
S ++ K+ L + + + D + ++ ++ E +
Sbjct: 310 ILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLK--MEVIS 367
Query: 666 LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLELNEQEATVL 724
LQ +K RKL T + D+AD E ++ + + E T L
Sbjct: 368 LQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSL 427
Query: 725 R---RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
++LE + K++ + +++ + K A S ++ N K EE++
Sbjct: 428 LGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSE--QNKNHINNELKRKEEQLSS 485
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKK-----PKTLIKSRSLDASDQQN------ 830
ED++ +V + E D +RL E+ + K+ T + S+ + +N
Sbjct: 486 YEDKLFDVCGSQ-DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPV 544
Query: 831 ----VDLKRQLQ-VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL 885
+ +LQ VI S LR L++ +L+ + K+ + +R +DL
Sbjct: 545 CQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMR-QSIIDL 603
Query: 886 NTKKTTQLENELKEALAKIKELEMICQD----------EKSEKKVRFTEATKKETDTLKS 935
K+ +L N+L+ I+ L+ ++ E+ KV T+ T E ++
Sbjct: 604 KEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL 663
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVE 994
K T++ + + Q+ K +++K++L +K+++
Sbjct: 664 KD---VERKIAQQAAKLQGIDLDRTVQQVNQEKQEK-----QHKLDTVSSKIELNRKLIQ 715
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
D + +I ++ L +++ T L++ R +L + E + E L EI
Sbjct: 716 DQQEQI--QHLKSTTNELKSEKLQISTNLQR-----RQQLEEQTVELSTEVQSLYREIKD 768
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
K+ + LE + F + + L N+ + + + ++K + I+ D++N
Sbjct: 769 AKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIEN 824
Score = 46.8 bits (106), Expect = 8e-04
Identities = 79/406 (19%), Positives = 160/406 (39%), Gaps = 23/406 (5%)
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS-LTT 769
KL+ E E EA + + + + + +KQ+ E+ K KT G + L+
Sbjct: 259 KLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDK-----KTGLGRIIELKSEILSK 313
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
N+L + VK +++ +++E +++ + ELS A+K + + +
Sbjct: 314 KQNEL--KNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 371
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL--NT 887
DL R L+ ++QE L T + + + K + ++ KS SD+ L
Sbjct: 372 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYF 431
Query: 888 KKTTQLENELKEALAKIKELEMICQD-EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
QLE+ L +K KE+ K K++ +E K + ++
Sbjct: 432 PNKKQLEDWLH---SKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYED 488
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPR-IPKKPTDLTTKLQLKKMVEDLECEIGEMYV 1005
++ L LK++ +KS K R + T + ++ + E+ C V
Sbjct: 489 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 548
Query: 1006 VMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
A L ++KL D KL +SE +K + + E+ L + +
Sbjct: 549 FQTEAELQEVISDLQSKLRLAPD----KLKSTESEL-KKKEKRRDEMLGLVPMRQSI--- 600
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
D+ + L N+ N++ + L +++ +E + + + ++A
Sbjct: 601 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 646
Score = 45.6 bits (103), Expect = 0.002
Identities = 105/600 (17%), Positives = 236/600 (39%), Gaps = 39/600 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
N K+ +D + +E++ R R ++ KE L N + N + ++ +
Sbjct: 433 NKKQLEDWLHSKSKEINQTRDRLAKLNKE----LASSEQNKNHINNELKRKEEQLSSYED 488
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLAAETLCEE 383
K+ ++ ++D + L ++I + + A Q I QL + + +C+
Sbjct: 489 KLFDVCG-SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQR 547
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSFKLKKTE 442
+ ++++ + DL D + +++ + RR+ + R LK E
Sbjct: 548 VFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLK--E 605
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL--EQEVARS--TEVAL--RLQREL 496
++ +L + + + + D ++E + + E+E A+ T+V + R Q EL
Sbjct: 606 KEIPELRNKLQNVNRDIQRLKN--DIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL 663
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL-REQ 555
+ K L + TV+ QE +L D++ + +L R+
Sbjct: 664 KDVERKIAQQAAKLQGIDLDRTVQQVNQE-----KQEKQHKL-----DTVSSKIELNRKL 713
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
+++ +E+ + K +K ++ N+ E +TV S + + ++ +KE+
Sbjct: 714 IQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYR-EIKDAKEQ 772
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
+++K +E + + S N +A + L +V+ + + +
Sbjct: 773 VSPLETTLEKFQQEKEELINKKNTS--NKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK 830
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE------QEATVLRRKVE 729
K NK+ + + KE D M+ ++ + Q+ LR++ E
Sbjct: 831 DDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNE 890
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
EL++ +E K+ +KE+ ++ + S ++ LA R K E+EI
Sbjct: 891 ELKEVEEERKQHLKEM-GQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHF 949
Query: 790 RKKLIEKE-RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
+K+L E + RD E + E+ + + + + K + +K +E+ ++R
Sbjct: 950 KKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIR 1009
>AF057299-1|AAD50325.1| 1312|Homo sapiens RAD50-2 protein protein.
Length = 1312
Score = 70.9 bits (166), Expect = 4e-11
Identities = 156/868 (17%), Positives = 356/868 (41%), Gaps = 55/868 (6%)
Query: 263 DSNVKEYQDQI-EGLKQEVDILRKRCERVEKEKSDILL---RRLANIDTANKYTTGRSSE 318
+S ++E +++ +G ++++ L +R +EK L+ R L ++ ++ SE
Sbjct: 286 NSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSE 345
Query: 319 VLKLQQKVN-ELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQL-RAKLL 375
+L Q ++ + H E +R + ++E + E P +E Q + +L R +
Sbjct: 346 LLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE 405
Query: 376 AAETLCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR 432
+LM+ E E +K++ D E +++ S + EL KN +
Sbjct: 406 GEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNEL----KNVK 461
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
+L+ + + +L+QE + E++L + + + + L+ E A +L
Sbjct: 462 YELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKL 521
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+E+ + N T + + + + + K + + ++ LL + + E L
Sbjct: 522 DQEMEQLN-HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWL 580
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
+ + + ++N +Q N + ++ E +S ++K+ +
Sbjct: 581 HSKSKEINQTRDRLAKLNKELASSEQ--NKNHINNELKRKEEQLSSYEDKLFDVCGSQDF 638
Query: 613 KEKSDSPPLSIDKTTEETQF--HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ D I+K++++ Y + N ++ V + +L++
Sbjct: 639 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDEN--QSCCPVCQRVFQTEAELQE 696
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDE-ADPAEMK-LLLELNEQEATVLRRKV 728
+ + +S KL P K S E+ EK DE M+ +++L E+E LR K+
Sbjct: 697 VISDLQS-KLRLAPDKLK-STESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 754
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
+ + +D + LK ++E + + ++ +A+ LT + ER ++ E+ +
Sbjct: 755 QNVNRDIQRLKNDIEEQETLLGTIMP----EEESAKVCLT---DVTIMERFQM---ELKD 804
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
V +K+ ++ + + + ++ Q + K LD + ++L R+L + +Q+ +
Sbjct: 805 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK-IELNRKL-IQDQQEQIQH 862
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
K+ + E +EKLQ L+ + L ++ ++L+T + L E+K+A ++ LE
Sbjct: 863 LKSTTNELKSEKLQISTN----LQRRQQL-EEQTVELST-EVQSLYREIKDAKEQVSPLE 916
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ + EK+ E K+ + K Q + ++ KDD
Sbjct: 917 TTLEKFQQEKE----ELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY 972
Query: 969 QKSFKPRIPKKPTDLT-TKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE--K 1025
+K + + K L+ + +K+ ED+ ++ +T + + E K
Sbjct: 973 KKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK 1032
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
E++E R + K + + ++++E KL++ ++ + ++ + K E E +
Sbjct: 1033 EVEEERKQHLKEMGQM--QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKK 1090
Query: 1086 QCKT---LTEEMKNREAQINKLSADLKN 1110
+ + E K RE I + +L N
Sbjct: 1091 ELREPQFRDAEEKYREMMIVMRTTELVN 1118
Score = 63.3 bits (147), Expect = 9e-09
Identities = 168/886 (18%), Positives = 333/886 (37%), Gaps = 82/886 (9%)
Query: 277 KQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDL 336
K E L R + + L + A ID + G S VL N + H ED
Sbjct: 108 KTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLN-----NVIFCHQEDS 162
Query: 337 R---DEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKK 393
E K L QK EI S + E RQ+ Q + + + + + + + ++
Sbjct: 163 NWPLSEGKALKQKFDEIFSATRYIKALET-LRQVRQTQGQKVKEYQMELKYLKQYKEKAC 221
Query: 394 ELRDLXXXXXXMQDNFRE------DQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
E+RD + +E ++ D + +E+E + L ++K + + Q
Sbjct: 222 EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQ 281
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAEAN--SKFT 504
+E++ +E E+K+ ++ G D ++ N + Q R E L REL + N S+
Sbjct: 282 MEKDNSELEEKMEKVFQGTD--EQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLL 339
Query: 505 GSNPSLMKVPQPE-TVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLEREADLREQLRN---- 558
S + V Q ++ R L L+ D ER Q++N
Sbjct: 340 NQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL 399
Query: 559 -AEEETANCKQVNP--PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
E + K N F +K+ + + +I + +T I S ++ K
Sbjct: 400 VRERQEGEAKTANQLMNDFAEKETLKQKQID-EIRDKKTGLGRIIELKSEILSKKQNELK 458
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
+ L + + + D + ++ ++ E + LQ +K
Sbjct: 459 NVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLK--MEVISLQNEKADLDR 516
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLELNEQEATVLR---RKVEEL 731
RKL T + D+AD E ++ + + E T L ++L
Sbjct: 517 TLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQL 576
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
E + K++ + +++ + K A S ++ N K EE++ ED++ +V
Sbjct: 577 EDWLHSKSKEINQTRDRLAKLNKELASSE--QNKNHINNELKRKEEQLSSYEDKLFDVCG 634
Query: 792 KLIEKERDCERLHAELSLAQKK-----PKTLIKSRSLDASDQQN----------VDLKRQ 836
+ E D +RL E+ + K+ T + S+ + +N + +
Sbjct: 635 SQ-DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE 693
Query: 837 LQ-VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
LQ VI S LR L++ +L+ + K+ + +R +DL K+ +L N
Sbjct: 694 LQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMR-QSIIDLKEKEIPELRN 752
Query: 896 ELKEALAKIKELEMICQD----------EKSEKKVRFTEATKKETDTLKSKQXXXXXXXX 945
+L+ I+ L+ ++ E+ KV T+ T E ++ K
Sbjct: 753 KLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKD---VERKI 809
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEMY 1004
T++ + + Q+ K +++K++L +K+++D + +I +
Sbjct: 810 AQQAAKLQGIDLDRTVQQVNQEKQEK-----QHKLDTVSSKIELNRKLIQDQQEQI--QH 862
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
+ L +++ T L++ R +L + E + E L EI K+ + LE
Sbjct: 863 LKSTTNELKSEKLQISTNLQR-----RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLET 917
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
+ F + + L N+ + + + ++K + I+ D++N
Sbjct: 918 TLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIEN 963
Score = 46.8 bits (106), Expect = 8e-04
Identities = 79/406 (19%), Positives = 160/406 (39%), Gaps = 23/406 (5%)
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS-LTT 769
KL+ E E EA + + + + + +KQ+ E+ K KT G + L+
Sbjct: 398 KLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDK-----KTGLGRIIELKSEILSK 452
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
N+L + VK +++ +++E +++ + ELS A+K + + +
Sbjct: 453 KQNEL--KNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 510
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL--NT 887
DL R L+ ++QE L T + + + K + ++ KS SD+ L
Sbjct: 511 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYF 570
Query: 888 KKTTQLENELKEALAKIKELEMICQD-EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
QLE+ L +K KE+ K K++ +E K + ++
Sbjct: 571 PNKKQLEDWLH---SKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYED 627
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPR-IPKKPTDLTTKLQLKKMVEDLECEIGEMYV 1005
++ L LK++ +KS K R + T + ++ + E+ C V
Sbjct: 628 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 687
Query: 1006 VMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
A L ++KL D KL +SE +K + + E+ L + +
Sbjct: 688 FQTEAELQEVISDLQSKLRLAPD----KLKSTESEL-KKKEKRRDEMLGLVPMRQSI--- 739
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
D+ + L N+ N++ + L +++ +E + + + ++A
Sbjct: 740 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 785
Score = 45.6 bits (103), Expect = 0.002
Identities = 105/600 (17%), Positives = 236/600 (39%), Gaps = 39/600 (6%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
N K+ +D + +E++ R R ++ KE L N + N + ++ +
Sbjct: 572 NKKQLEDWLHSKSKEINQTRDRLAKLNKE----LASSEQNKNHINNELKRKEEQLSSYED 627
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQ-IEQLRAKLLAAETLCEE 383
K+ ++ ++D + L ++I + + A Q I QL + + +C+
Sbjct: 628 KLFDVCG-SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQR 686
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQAD-EYSSLRRELEQTIKNCRVLSFKLKKTE 442
+ ++++ + DL D + +++ + RR+ + R LK E
Sbjct: 687 VFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLK--E 744
Query: 443 RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL--EQEVARS--TEVAL--RLQREL 496
++ +L + + + + D ++E + + E+E A+ T+V + R Q EL
Sbjct: 745 KEIPELRNKLQNVNRDIQRLKN--DIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL 802
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL-REQ 555
+ K L + TV+ QE +L D++ + +L R+
Sbjct: 803 KDVERKIAQQAAKLQGIDLDRTVQQVNQE-----KQEKQHKL-----DTVSSKIELNRKL 852
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEK 615
+++ +E+ + K +K ++ N+ E +TV S + + ++ +KE+
Sbjct: 853 IQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYR-EIKDAKEQ 911
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKA 675
+++K +E + + S N +A + L +V+ + + +
Sbjct: 912 VSPLETTLEKFQQEKEELINKKNTS--NKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK 969
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE------QEATVLRRKVE 729
K NK+ + + KE D M+ ++ + Q+ LR++ E
Sbjct: 970 DDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNE 1029
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEV 789
EL++ +E K+ +KE+ ++ + S ++ LA R K E+EI
Sbjct: 1030 ELKEVEEERKQHLKEM-GQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHF 1088
Query: 790 RKKLIEKE-RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
+K+L E + RD E + E+ + + + + K + +K +E+ ++R
Sbjct: 1089 KKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIR 1148
>BC049849-1|AAH49849.1| 1374|Homo sapiens Unknown (protein for
IMAGE:5563109) protein.
Length = 1374
Score = 70.5 bits (165), Expect = 6e-11
Identities = 93/423 (21%), Positives = 180/423 (42%), Gaps = 18/423 (4%)
Query: 699 EKETDEADPAEMKLLLELNEQEATVLRRKVEE--LEQDKEALKKQVKELTSKISSVTKTS 756
E++ +E + A KL LE EA + + + E+ LE L K+ K L +I+ T T+
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT-TN 1007
Query: 757 AGSNTTARRSLTTNSNKLAEERVKVLEDEI---DEVRKKLIEKERDCERLHAELSLAQKK 813
+SL NK E + LE+ + ++ R++L + R E +LS +
Sbjct: 1008 LTEEEEKSKSLAKLKNK-HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 814 PKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS---VLRAKTQSLEADNEKLQTENKKLQL 870
+ I + + ++ +L+ L +E+EA+ + K + LE+ +LQ + + +
Sbjct: 1067 LQAQIAELKMQLAKKEE-ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 871 LKN-AKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKE 929
+N A+ + D +L KT +LE+ L A+ +EL + E + K E K
Sbjct: 1126 SRNKAEKQKRDLGEELEALKT-ELEDTLDSTAAQ-QELRSKREQEVNILKKTLEEEAKTH 1183
Query: 930 TDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL 989
++ + +A L+ K + + L K
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS 1243
Query: 990 KKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKND---SEFTNEK 1045
+ + +E ++ E+ V E+ K TKL+ E+D + LS++D S+ T +
Sbjct: 1244 EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303
Query: 1046 NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLS 1105
+ L++++ +++ + K + K K +E+E ++ Q + E N E QI L
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363
Query: 1106 ADL 1108
A +
Sbjct: 1364 AQV 1366
Score = 66.1 bits (154), Expect = 1e-09
Identities = 109/458 (23%), Positives = 194/458 (42%), Gaps = 63/458 (13%)
Query: 709 EMKLLLELNEQEATVLRRKVE--ELEQDKEALKKQVKELTSKISSVT--KTSAGSNTTAR 764
++K LL+++ QE ++ ++ E ++ + + A + ++ E+ + S + K A
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEV----RKKLIEKERDCERLHAELSLAQKKPKTLIKS 820
L + +L R+ + E++E+ ++ E+E C+ L AE +KK + I+
Sbjct: 893 TELCAEAEEL-RARLTAKKQELEEICHDLEARVEEEEERCQHLQAE----KKKMQQNIQE 947
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD 880
++++ K QL+ + EA K + LE + L+ +N KL K L D
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEA-----KLKKLEEEQIILEDQNCKLA---KEKKLLED 999
Query: 881 KALDLNTKKTTQLENELKEALAKIKELEMICQDE----KSEKKVRFTEATKKE-----TD 931
+ + T T + E A K K MI E + EK+ + E T+++ TD
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKK 991
QA L ++++A + K KK +L + Q+ +
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ--KNMALKKIRELES--QISE 1115
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTA-KTKLEKEIDEIRSKL---SKNDSEFTNEKNR 1047
+ EDLE E K G+E+ A KT+LE +D ++ SK + E K
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT 1175
Query: 1048 LQTEI----AKLKDVNAK-----------LEGDKDVFANKYKA---LENENSNLSNQCKT 1089
L+ E A+++++ K LE K V AN KA LENE L+N+ K
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV 1235
Query: 1090 LTE-------EMKNREAQINKLSADLKNATSLQTTMSD 1120
L + + K EAQ+ +L ++T ++D
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD 1273
Score = 66.1 bits (154), Expect = 1e-09
Identities = 114/558 (20%), Positives = 227/558 (40%), Gaps = 44/558 (7%)
Query: 277 KQEVDILRKRCERVE-KEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+QE +++ K E V+ +EK RL ++T ++ + Q EL E+
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 901
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL-CEELMDENEDMKKE 394
LR Q++ EI +LE R E + Q Q K + EE ++E E +++
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
Query: 395 LRDLXXXXXXMQDNFREDQ---ADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
L+ E+Q D+ L +E + + L + E K+ L +
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 452 KAEHEKKLLEIVGGPDGMQRENRIK-ELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
K +HE + ++ + ++RE + + ELE+ + + L ++AE ++ L
Sbjct: 1022 KNKHEAMITDL---EERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
K + ++R +E+ AQ L+ E E+ + E + E E A+ +
Sbjct: 1079 AKKEEELQAALAR-------VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA- 1130
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
+KQ E E + +++ + A+ + K + + KT EE
Sbjct: 1131 -----EKQKRDLG------EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ + + + + A ++E+ + + L+K A + + K+
Sbjct: 1180 AKTHE-AQIQEMRQKHSQAVEELAEQLEQ-TKRVKANLEK-AKQTLENERGELANEVKVL 1236
Query: 691 IETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKI 749
++ D++ K EA E+++ E+ T L KV +L+ + + + + + SK
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 750 SSVTKTSAGSNT----TARRSLTTNSNKLA-EERVKVLEDEIDEVRKKLIEK-------E 797
S +TK + + T N KL+ ++K +EDE + R++L E+ E
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 798 RDCERLHAELSLAQKKPK 815
+ LHA+++ +KK K
Sbjct: 1357 KQIATLHAQVADMKKKKK 1374
Score = 65.3 bits (152), Expect = 2e-09
Identities = 90/447 (20%), Positives = 191/447 (42%), Gaps = 27/447 (6%)
Query: 470 QRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG 529
++E + E+E+ + E L + L E + S K+ E ++
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMET--LQSQLMAEKLQLQEQLQAETELCAE- 898
Query: 530 GSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDI 589
++E A+L Q+ E DL ++ EEE C+ + +K+ M NI +
Sbjct: 899 -AEELRARLTAKKQELEEICHDLEARV---EEEEERCQHLQA----EKKKMQQNIQELE- 949
Query: 590 HESETVTNSIQNKMIHAASTPSSKEKSDSPPLSID----KTTEETQFHFDLPYLSIFNHM 645
+ E ++ Q + +T + +K + + ++ K +E + D N
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 646 AANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEA 705
K+ A+++ +E+++ L++ + ++ KL ++ + +D+ +A
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 706 DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR 765
AE+K+ L E+E +VEE K K+++EL S+IS + + S +R
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL-QEDLESERASRN 1128
Query: 766 SLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
L EE ++ L+ E+++ ++ + E+++ +K + K+
Sbjct: 1129 KAEKQKRDLGEE-LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL-QT-ENKKLQLLKNAKSLRSDKAL 883
+ + ++ Q +E+ A L +T+ ++A+ EK QT EN++ +L K L K
Sbjct: 1188 QEMR----QKHSQAVEELAEQLE-QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 884 DLNTKKTTQLENELKEALAKIKELEMI 910
+ +K ++E +L+E K E E +
Sbjct: 1243 SEHKRK--KVEAQLQELQVKFNEGERV 1267
Score = 53.6 bits (123), Expect = 7e-06
Identities = 85/398 (21%), Positives = 159/398 (39%), Gaps = 36/398 (9%)
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE-----EHVVTKARLTVEKEQAQGE 1486
E+ + EE VK E LA E E T + +L+ E E + + L E E+ +
Sbjct: 846 EMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRAR 905
Query: 1487 LLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLN 1546
L ++EL +++ E+ EK +MQ +I L+E+L E E AR
Sbjct: 906 LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL----EEEESARQK 961
Query: 1547 ARLDQ--RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXX 1604
+L++ E +L+ + + +LE + ++ +
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 1605 XXXXXXXXXXIEQ---SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNY 1661
+E+ E+ ++ E+ T+ + EG + D++ L Q++ + +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 1662 KQML---------EAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVAL----LEQQV 1708
++ L EAAQK+MA K + ++I E RNK L +++
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141
Query: 1709 ACLEDELCESRLLASKLNTELVSEKSSAEVRL----AEMQSRLNEYEEERLLSSGRARVA 1764
L+ EL E L ++ EL S K EV + E +++ +E + + + V
Sbjct: 1142 EALKTEL-EDTLDSTAAQQELRS-KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 1765 GLATRMELAWHKERD---EQQRLLQETSTLARDLRQTL 1799
LA ++E + + +Q L E LA +++ L
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
Score = 46.8 bits (106), Expect = 8e-04
Identities = 103/541 (19%), Positives = 211/541 (39%), Gaps = 51/541 (9%)
Query: 981 TDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKNDS 1039
T++ T LQ + M E L+ + E +E+ A+ T ++E++EI L
Sbjct: 869 TEMET-LQSQLMAEKLQLQ--EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVE 925
Query: 1040 EFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
E LQ E K++ +LE + + + L+ E + K L EE E
Sbjct: 926 EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILED 985
Query: 1100 QINKLSADLK----NATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQD 1155
Q KL+ + K T +++ ++ K Q+
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE 1045
Query: 1156 KNKLLKEV-GDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVV 1214
K +++ GD T D ++ QL+ +++ + Q +
Sbjct: 1046 LEKTRRKLEGDST----DLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 1215 LANTHRRLSIELTSEKDELQARFI---KTESKFITLEAEMRDLKADYENKITSLESTIAA 1271
R L +++ +++L++ K E + L E+ LK + E+ +L+ST A
Sbjct: 1102 ALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED---TLDSTAAQ 1158
Query: 1272 KDVHIKQLEDA--LRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE 1329
+++ K+ ++ L++T + + T ++ EMR ++ K LE
Sbjct: 1159 QELRSKREQEVNILKKTLEE--EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLE 1216
Query: 1330 KTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERK 1389
K + + E +L +++ L E+K K+++ LQ +
Sbjct: 1217 KAK---QTLENERGELANEVKVLLQGKGDS--------------EHKRKKVEAQLQELQV 1259
Query: 1390 KL---DRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEH 1446
K +R+R V EL + G L + S K + L+ + ++T + L+
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319
Query: 1447 SLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQE 1506
E + L+ K + +E+E + +L E+E+A+ L +K+++T ++ +++
Sbjct: 1320 ----ENRQKLSLSTKLKQVEDEKNSFREQLE-EEEEAKHNL---EKQIATLHAQVADMKK 1371
Query: 1507 K 1507
K
Sbjct: 1372 K 1372
Score = 43.2 bits (97), Expect = 0.010
Identities = 65/298 (21%), Positives = 122/298 (40%), Gaps = 32/298 (10%)
Query: 1246 TLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRX 1305
TL++++ K + ++ + E+ + A+ ++ A +Q + + + VE E R
Sbjct: 873 TLQSQLMAEKLQLQEQLQA-ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERC 931
Query: 1306 XXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXX 1365
Q + + +LE+ E+ +LE ++ L KLE
Sbjct: 932 QHLQAEKKKM--QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCK 989
Query: 1366 XXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGA 1425
E++ E T+L E +K LA LK K + + +
Sbjct: 990 LAKEKKLLEDRIAEFTTNLTEEEEK---------------SKSLAKLKNKHEAMITDLEE 1034
Query: 1426 GAKRITELKQEYEETVKKLE-------HSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
+R + +QE E+T +KLE +A +A+ EL K +L ++E + A V
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL--KMQLAKKEEELQAALARV 1092
Query: 1479 EKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWN---TEKTEMQNSIASLQERL 1533
E+E AQ + K++ +I LQE L +E A+ N +K ++ + +L+ L
Sbjct: 1093 EEEAAQKNM--ALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Score = 42.7 bits (96), Expect = 0.013
Identities = 66/334 (19%), Positives = 129/334 (38%), Gaps = 26/334 (7%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E + L K +N E + +ER RR + +E EKT R + S+ D +Q +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
LK + + ++E + QI L+++++ R
Sbjct: 1071 ----IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 287 CERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKLQQKVN--------ELTTHNED 335
+ EK+K D+ L ++ T + K +Q+VN E TH
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 336 LRDEKKHLTQKIREIESELE----TRPSTEAQTRQIEQLRAKLL-AAETLCEELMDENED 390
+++ ++ +Q + E+ +LE + + E + +E R +L + L + D
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246
Query: 391 MKK---ELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
KK +L++L + R + AD+ + L+ EL+ K K +
Sbjct: 1247 RKKVEAQLQELQVKFNE-GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE 481
LE + + ++ L E + ++K++E E
Sbjct: 1306 LESQLQDTQELLQE--ENRQKLSLSTKLKQVEDE 1337
>AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion protein
protein.
Length = 1492
Score = 70.5 bits (165), Expect = 6e-11
Identities = 142/682 (20%), Positives = 289/682 (42%), Gaps = 70/682 (10%)
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR----ENRIKELEQEVARSTEVALRL 492
++ ++E Q E E+ E + + + G +G+Q+ E IK+ + + + T +
Sbjct: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
Query: 493 QRELAEANSKF---TGSNPSLM----KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
+RE E +F T + L ++ ET++ S S T + Q+L Q
Sbjct: 218 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH-QQQ 276
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
LE + L E + +E+ Q+ +FL +++ ++E E Q+K +
Sbjct: 277 LEEQDHLLEDYQKKKEDFT--MQI---SFLQEKI--------KVYEME------QDKKVE 317
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
++ +EK K EE + +L L++ + ++ +++
Sbjct: 318 NSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 377
Query: 666 LQLKKMATKAR-SRKLSPTPPANKLSIETANDNDEK-ETDEADPAEMKLLLELNEQEATV 723
L+L K R S + ++ N D + ETD E + +L + A +
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
+++ Q K+ L +++ +++ + G A RS + + + E+++K++
Sbjct: 438 DEMYGQQIVQMKQEL---IRQHMAQMEEMKTRHKGEMENALRSYSNIT--VNEDQIKLMN 492
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
I+E+ KL + E+L EL L ++ L R L+ DL +L ++
Sbjct: 493 VAINELNIKLQDTNSQKEKLKEELGLILEEKCAL--QRQLE-------DLVEELSFSREQ 543
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ RA+ Q++ KL +K L +++ L+++ ++K +L++E + K
Sbjct: 544 --IQRAR-QTIAEQESKLNEAHKSLSTVED---LKAEIVSASESRKELELKHEAEVTNYK 597
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
IK LEM+ + EK+ R E+ + E + L++ Q + ++
Sbjct: 598 IK-LEML-EKEKNAVLDRMAESQEAELERLRT-QLLFSHEEELSKLKEDLEIEHRINIEK 654
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED--------LECEIGEMYVVMKN-AGLSG 1014
LKD+ +K +I +++ K++ + +D L EI ++ + ++
Sbjct: 655 LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS 714
Query: 1015 KEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+EMT + +L+KEI+ +R + K E LQ + L+ + E D K+
Sbjct: 715 EEMTLQINELQKEIEILRQE-EKEKGTLEQEVQELQLKTELLEKQMKEKEND---LQEKF 770
Query: 1074 KALENENSNLSNQCKTLTEEMK 1095
LE ENS L ++ KTL + +K
Sbjct: 771 AQLEAENSILKDEKKTLEDMLK 792
Score = 62.1 bits (144), Expect = 2e-08
Identities = 130/691 (18%), Positives = 286/691 (41%), Gaps = 59/691 (8%)
Query: 267 KEYQDQIEGLKQEVDILR-KRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+++ QI L++++ + ++ ++VE + + + I+ N + L+L+ K
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 351
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
LTT ++ L + ++ + QK +EI++ +LE S + + + E+++ + E L +
Sbjct: 352 ---LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 408
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++ ++ + + R + + Y +++Q + + + KT K
Sbjct: 409 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 468
Query: 445 ADQLEQEKA-------EHEKKLLEIVGGPDG--MQRENRIKE-LEQEVARSTEVALRLQR 494
+ ++ E + KL+ + +Q N KE L++E+ E LQR
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L + + + S + + Q T+ S L + DL+ + ++ R+
Sbjct: 529 QLEDLVEELSFSREQIQRARQ--TIAEQESKLNEAHKS---LSTVEDLKAEIVSASESRK 583
Query: 555 QLR-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
+L E E N K +K + D + E ++ +++ + SK
Sbjct: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA----ESQEAELERLRTQLLFSHEEELSK 639
Query: 614 EKSD---SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
K D ++I+K + H+ + N M+ + + E+DN
Sbjct: 640 LKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ---KIETMQFEKDN--------- 687
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEATVLRRKVE 729
+ TK +++ + L N E+ T + + + ++ +L E+E L ++V+
Sbjct: 688 LITK-QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ 746
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL-------AEERVKVL 782
EL+ E L+KQ+KE + + N+ + T + L EER+ L
Sbjct: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQ---KKPKTLIKSRSLDASDQQNVDLKRQLQV 839
+ + + + EKE + + L Q + + + K R+ + ++N ++ Q ++
Sbjct: 807 DSIKSKSKDSVWEKEIEI-LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-EL 864
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENK-KLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
E+ A +L+ K LE K + E K KL+ L + L + K + + +E K
Sbjct: 865 QEEYACLLKVK-DDLEDSKNKQELEYKSKLKALN--EELHLQRINPTTVKMKSSVFDEDK 921
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKE 929
+A+ E+ + + + +E + E TK+E
Sbjct: 922 TFVAETLEMGEVVEKDTTELMEKL-EVTKRE 951
Score = 55.2 bits (127), Expect = 2e-06
Identities = 149/790 (18%), Positives = 330/790 (41%), Gaps = 65/790 (8%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT--RQIEQLRAKLLAAETL 380
+Q + TH E + E +I E+ ELE T +Q+++ A + + +
Sbjct: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206
Query: 381 CEELMD-------ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKNCR 432
+L E ++ +E +L +Q F++ QA E +LR T +
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASE--TLRNSTHSSTAADLL 264
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ +++ ++ + +++KK + +Q + ++ E+EQ+ +V
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----KKVENSN 320
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+ E+ E + N +++ + +T+++ + LT +LL +LQ+ + ++
Sbjct: 321 KEEIQEKETIIEELNTKIIE-EEKKTLEL-KDKLTTAD------KLLGELQEQIVQK--- 369
Query: 553 REQLRNAEEETANCKQVNPPTFLD-KQVM-TDNIVTCDIHESETVTNSIQNKMIHAASTP 610
++++N + E N KQ + + KQ+M T + H+ I +M
Sbjct: 370 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ +++ + + + Q +L I HMA KT + E +N L
Sbjct: 430 LEQLRAELDEMYGQQIVQMKQ---EL----IRQHMAQMEEMKTRHKGEMENA--LRSYSN 480
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ KL N+L+I+ + N +KE + E+ L+LE L VEE
Sbjct: 481 ITVNEDQIKLMNVA-INELNIKLQDTNSQKEKLKE---ELGLILEEKCALQRQLEDLVEE 536
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTA--RRSLTTNSNKLAEERVKVLEDEIDE 788
L +E +++ + + + S + + +T + + + S E +K E E+
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKH-EAEVTN 595
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
+ KL E++ + ++ +Q+ ++++ L + +++ LK L+ IE ++ +
Sbjct: 596 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEK 654
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
K + K Q + + ++ + ++++ +K +L TK +N+L ++K+K+L+
Sbjct: 655 LKDNL--GIHYKQQIDGLQNEMSQKIETMQFEKD-NLITK-----QNQLILEISKLKDLQ 706
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ KSE+ +KE + L+ ++ + +K ++D
Sbjct: 707 QSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDL 766
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
Q+ F + K L+ M++ E ++ + S K + + EKEI
Sbjct: 767 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD---SIKSKSKDSVWEKEI- 822
Query: 1029 EIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
EI L + + + + +L EI K ++ + E + +V Y+ L+ E + L + K
Sbjct: 823 EI---LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLL-KVK 875
Query: 1089 TLTEEMKNRE 1098
E+ KN++
Sbjct: 876 DDLEDSKNKQ 885
Score = 44.8 bits (101), Expect = 0.003
Identities = 74/358 (20%), Positives = 155/358 (43%), Gaps = 27/358 (7%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA----AKD---VHIKQLE- 1280
EKDE F++ + L+ + + L+A + ++ ST A AK H +QLE
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 279
Query: 1281 -DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
D L + K ++ T + ++ + + N +I+ ++T E K
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKV--ENSNKEEIQEKETIIEELNTK 337
Query: 1340 LEMAQLKS-DLA-KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-- 1395
+ + K+ +L KL + +N EL Q ER+ + ++
Sbjct: 338 IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQL 397
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI-TELKQEYEETVKKLEHSLALE 1451
+ + +KD++ T ++ +EQ + +++ EL + Y + + +++ L +
Sbjct: 398 MGTVEELQKRNHKDSQFET--DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQ 455
Query: 1452 K-AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ-KELSTALGEIKTLQEKLG 1509
A+ EE+ +++ E + + + +TV ++Q + L++V EL+ L + + +EKL
Sbjct: 456 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK--LMNVAINELNIKLQDTNSQKEKLK 513
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
E EK +Q + L E L +++RAR + ++E +L A+ +E
Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRAR--QTIAEQESKLNEAHKSLSTVE 569
Score = 44.4 bits (100), Expect = 0.004
Identities = 82/447 (18%), Positives = 182/447 (40%), Gaps = 25/447 (5%)
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK- 1434
+AK+ Q + ++ D + + K ++ +++ L+ K+K+ E + + +
Sbjct: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
QE E +++L + E+ + EL K ++ + ++ + ++ + L +
Sbjct: 325 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSK 384
Query: 1495 STALGEIKTLQEKLGT--ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+ +++ +GT E N + ++ + I E+ E RA L+ Q+
Sbjct: 385 QKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 444
Query: 1553 ERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+++ R+ + + + Y ++ +
Sbjct: 445 IVQMKQELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ 503
Query: 1613 XXIEQSEKARK--AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
Q EK ++ I + K + Q+ + +EL Q+ R R+ + L A K
Sbjct: 504 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 1671 SMA---EIKNGDKSARIHRNSISSTDEEE---YRNKVALLEQQVACLEDELCESR-LLAS 1723
S++ ++K SA R + E E Y+ K+ +LE++ + D + ES+
Sbjct: 564 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 1724 KLNTELV---SEKSSAEVRLAEMQSRLN-EYEEERLLSSGRARVAGLATRME-----LAW 1774
+L T+L+ E+ S E++ R+N E ++ L + ++ GL M + +
Sbjct: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
Query: 1775 HKER--DEQQRLLQETSTLARDLRQTL 1799
K+ +Q +L+ E S L +DL+Q+L
Sbjct: 684 EKDNLITKQNQLILEISKL-KDLQQSL 709
>AY536375-1|AAT66048.1| 820|Homo sapiens rhabdomyosarcoma antigen
MU-RMS-40.19 protein.
Length = 820
Score = 70.5 bits (165), Expect = 6e-11
Identities = 166/871 (19%), Positives = 358/871 (41%), Gaps = 75/871 (8%)
Query: 720 EATVLRRKVEE-LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
+ V ++++E+ L Q E+ +K+V + S V + + +S A+
Sbjct: 1 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS 60
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
VL +E+ +V + EK++ ++ E SLA ++ + K L N LK ++Q
Sbjct: 61 ASVLAEELHKV---IAEKDKQIKQ--TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 115
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
++ A+ A LE + + ++ K++LL+ + L+ + + N + ++ N+
Sbjct: 116 KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE--EQLQHEIS---NKMEEFKILNDQN 170
Query: 899 EAL-AKIKELEMICQDEKSEKKVRFTEATKKETD-TLKSKQXXXXXXXXXXXXXXXXXXX 956
+AL +++++L+ + ++ ++ V E +E D LK+ +
Sbjct: 171 KALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNA 230
Query: 957 XQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
+ SL + Q K + + + + +LKK++ + + +I + +++ E
Sbjct: 231 IRTENSSLTKEVQ-DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLE------AE 283
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ EK + +++ ++ E N EK + + +K++++ L+G ++
Sbjct: 284 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 343
Query: 1074 KALENENSNLSNQCK---TLTEEMKNREAQINKLSA-DLKNATSLQTTMSDCMXXXXXXX 1129
LE + +L+N K L EE ++ +A + +++ +LK A+S + +
Sbjct: 344 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS-ASQFEELEIVLKEKE 402
Query: 1130 XXXXXXXXXXXXXXXQVDNYTKI---DQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKR 1186
+ + T++ QD+NKL K + +++ +
Sbjct: 403 NELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK---SQIEQLKQQNYQQASSFPPHEE 459
Query: 1187 IEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFIT 1246
+ K +S R+ ++ AV R+ + +L + E TE
Sbjct: 460 LLKVISEREKEIS-GLWNELDSLKDAV---EHQRKKNNDLREKNWEAMEALASTEK---M 512
Query: 1247 LEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXX 1306
L+ ++ + + ++ ++E + AK+V +K+L + +N Y E E
Sbjct: 513 LQDKVNKTSKERQQQVEAVE--LEAKEV-LKKLFPKVSVPSNLSYGEWLHGFE------K 563
Query: 1307 XXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXX 1366
+E+ + KL++ + + +LE + KS LA+ E
Sbjct: 564 KAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG---ILQKLQRSV 620
Query: 1367 XXXSSYWENKA-------KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKIL 1419
+ W+ K K++ + S ++L+R+R + +KD++N E L+ +L+
Sbjct: 621 EQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR-SENKDIENLRREREHLEMELEKA 679
Query: 1420 EQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVE 1479
E + ELK E KKL+ S + + EEL LL+ + T +L E
Sbjct: 680 EMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEEL----NLLKAQLNETLTKLRTE 735
Query: 1480 KEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWE 1539
+ + Q V +L A ++ +Q K+ AA +T T ++NS S + E
Sbjct: 736 QNERQ----KVAGDLHKAQQSLELIQSKI--VKAAGDT--TVIENSDVSPETE--SSEKE 785
Query: 1540 VERARLNARLDQRERELRAANDRRDVLEHHH 1570
LN + Q ++ L+A N + + H+
Sbjct: 786 TMSVSLNQTVTQLQQLLQAVNQQLTKEKEHY 816
Score = 59.7 bits (138), Expect = 1e-07
Identities = 82/421 (19%), Positives = 188/421 (44%), Gaps = 29/421 (6%)
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
+N++E+ L+ +V+++ + EALK Q+++ S+I++ +TSA + +K
Sbjct: 24 VNKEES--LQMQVQDILEQNEALKAQIQQFHSQIAA--QTSASVLAEELHKVIAEKDK-- 77
Query: 776 EERVKVLEDEIDEVRKKLIEKE---RDCERLHAELSLAQKKPKTLIKSRSLDASD----Q 828
++K ED + R +L KE +D + ++ L +K + L ++ A + Q
Sbjct: 78 --QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQ 135
Query: 829 QNVDLKR-QLQVIEQEAS-VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN 886
Q+V +K +++++E++ + K + + N++ + ++Q L+ S + +K +
Sbjct: 136 QSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQ 195
Query: 887 TKKTTQLENELKEALAKIKELEMICQDEKSEK--KVRFTEAT-KKETDTLKSKQXXXXXX 943
+K Q ++E + + ++ E +I K E+ +R ++ KE LK+KQ
Sbjct: 196 MEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSF 255
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL-ECEIGE 1002
+KS+++ + K+ T K ++K + E++ ++ +
Sbjct: 256 ASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEK 315
Query: 1003 MYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL 1062
+ + + + K K E++++ +++ L + + + N LQ L++ N L
Sbjct: 316 AQQLSITSKVQELQNLLKGK-EEQMNTMKAVLEEKEKDLANTGKWLQD----LQEENESL 370
Query: 1063 EGDKDVFAN---KYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
+ A K + ++ L K E+K EA + + +DL + T L +
Sbjct: 371 KAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ 430
Query: 1120 D 1120
D
Sbjct: 431 D 431
Score = 54.4 bits (125), Expect = 4e-06
Identities = 76/403 (18%), Positives = 175/403 (43%), Gaps = 25/403 (6%)
Query: 716 LNEQEATVLRRKVEE---LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L EQ + K+EE L +ALK +V++L + +S + +
Sbjct: 148 LEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE----QPNKDVVEQMEKCIQEK 203
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
+E++K +E+ ++ ++ KE + + E S K+ + L K++ D ++
Sbjct: 204 ---DEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDL-KAKQNDQVSFASL- 258
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA-KSLRSD-------KALD 884
++ +VI ++ +++ + LEA+ K+ + K +Q LK K+L+ + KA
Sbjct: 259 VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ 318
Query: 885 LN-TKKTTQLENELKEALAKIKELEMICQDEKSE--KKVRFTEATKKETDTLKSKQXXXX 941
L+ T K +L+N LK ++ ++ + ++++ + ++ + ++E ++LK+
Sbjct: 319 LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 378
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
+ LK K++ K + + ++ +DL++K QL + V+D
Sbjct: 379 QHNLKEASSASQFEELEIVLKE-KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK 437
Query: 1002 EMYVVMKNAGL-SGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
+K +L K I E ++S +E + K+ ++ + K D+
Sbjct: 438 SQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLRE 497
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
K + A+ K L+++ + S + + E ++ ++ K
Sbjct: 498 KNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLK 540
Score = 53.6 bits (123), Expect = 7e-06
Identities = 136/698 (19%), Positives = 298/698 (42%), Gaps = 64/698 (9%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEK-EKSDILLR-RLANIDTANKYTTGRSSEVL 320
D +K+ +D L E D L + E ++ + + LL+ + + + E+
Sbjct: 76 DKQIKQTEDS---LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 132
Query: 321 KLQQKVNELTTHNEDLRDEKKH-LTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
K+QQ V L ++ +H ++ K+ E + + + +++ ++++ L ++ +
Sbjct: 133 KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDV 192
Query: 380 L--CEELMDENEDMKKELRDLXXXXXXMQDNFREDQAD----EYSSLRRELE--QTIKNC 431
+ E+ + E ++ K + +L +Q +E++ + E SSL +E++ + +N
Sbjct: 193 VEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQDLKAKQND 251
Query: 432 RVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
+V L + +K + K + ++LLE +E +++L+QE+ E
Sbjct: 252 QVSFASLVEELKKVIHEKDGKIKSVEELLE-AELLKVANKEKTVQDLKQEIKALKEEIGN 310
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
+Q E A+ S T L + + + +++ ++D A + LQD E
Sbjct: 311 VQLEKAQQLS-ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 369
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPS 611
L+ ++ + N K+ + + ++ + + E E ++ + S S
Sbjct: 370 LKAHVQEVAQH--NLKEASSASQFEELEIV-------LKEKENELKRLEAMLKERESDLS 420
Query: 612 SKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKM 671
SK + L D E F + L N+ A++ +E LL + +
Sbjct: 421 SKTQ-----LLQDVQDENKLFKSQIEQLKQQNYQQASSF--------PPHEELLKVISER 467
Query: 672 ATKARS--RKLSPTPPANKLSIETANDNDEK--ETDEADPAEMKLLLELNEQEATVLRRK 727
+ +L A + + ND EK E EA + K+L + + + +++
Sbjct: 468 EKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQ 527
Query: 728 VEELEQD-KEALKKQVKELTSKISSVTKTSAGS--NTTARRSLTTNSNKLAEERVKVLED 784
VE +E + KE LKK L K+S + S G + +++ + E VKVLE
Sbjct: 528 VEAVELEAKEVLKK----LFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEH 583
Query: 785 EIDEVRKKLIEKERDCERLHAELS----LAQKKPKTLIKSRS-----LDASDQQNVDLKR 835
++ E + + +CE+ + L+ + QK +++ + + +D S + ++
Sbjct: 584 KLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQS 643
Query: 836 QLQVIEQEASVLRAKTQSLE---ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
EQE LR++ + +E + E L+ E +K ++ ++ + DL T+ +
Sbjct: 644 SFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKK 703
Query: 893 LENELKEALAKIKELEMI-CQDEKSEKKVRFTEATKKE 929
L++ EA+ + +EL ++ Q ++ K+R TE +++
Sbjct: 704 LDDSYSEAVRQNEELNLLKAQLNETLTKLR-TEQNERQ 740
Score = 44.4 bits (100), Expect = 0.004
Identities = 148/704 (21%), Positives = 281/704 (39%), Gaps = 88/704 (12%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
++E ++Q V + + +E++ + ++ N SEV KLQ V+E
Sbjct: 130 ELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPN 189
Query: 332 HNEDLRDEK--KHLTQKIREIESELET---------------RPSTEAQTRQIEQLRAKL 374
+ + EK + +K++ +E LET R + T++++ L+AK
Sbjct: 190 KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQ 249
Query: 375 ---LAAETLCEELMD--ENEDMK----KELRDLXXXXXXMQDNFREDQADEYSSLRRELE 425
++ +L EEL +D K +EL + ++ +D E +L+ E+
Sbjct: 250 NDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIG 309
Query: 426 QT-IKNCRVLSFKLKKTER------KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL 478
++ + LS K E K +Q+ KA E+K ++ G ++ +E
Sbjct: 310 NVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLAN--TGKWLQDLQEEN 367
Query: 479 EQEVARSTEVALRLQRELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLTRGGSQEDPAQ 537
E A EVA Q L EA+S + +K + E ++ R Q
Sbjct: 368 ESLKAHVQEVA---QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQ 424
Query: 538 LLRDLQDSLEREADLREQLRNAEEETANC-----KQVNPPTFLDKQVM-----TDNIVTC 587
LL+D+QD + EQL+ + A+ + + + +K++ D++
Sbjct: 425 LLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDA 484
Query: 588 DIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAA 647
H+ + N ++ K A +S EK ++KT++E Q + L A
Sbjct: 485 VEHQRKK-NNDLREKNWEAMEALASTEKMLQD--KVNKTSKERQQQVEAVELE-----AK 536
Query: 648 NNLRKTAARVE-EDNESLLLQLKKMATKARSRKLSPTPPANKLSI--ETANDNDEKETD- 703
L+K +V N S L KA+ ++ T + ++ + + DE T
Sbjct: 537 EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKEC-MAGTSGSEEVKVLEHKLKEADEMHTLL 595
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
+ + + K +L E L+R VE+ E++K +K T K + TS+
Sbjct: 596 QLECEKYKSVLAETEGILQKLQRSVEQ-EENKWKVKVDESHKTIKQMQSSFTSSEQELER 654
Query: 764 RRSLTTNSNKLAEER--------------------VKVLEDEIDEVRKKLIEKERDCERL 803
RS + L ER V+ L+D + E++KKL + + R
Sbjct: 655 LRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ 714
Query: 804 HAELSLAQKK-PKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ 862
+ EL+L + + +TL K R+ + +++Q V L +Q ++++K D ++
Sbjct: 715 NEELNLLKAQLNETLTKLRT-EQNERQKV--AGDLHKAQQSLELIQSKIVKAAGDTTVIE 771
Query: 863 TENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
+ + + K S +L+ + QL + + L K KE
Sbjct: 772 NSDVSPETESSEKETMS-VSLNQTVTQLQQLLQAVNQQLTKEKE 814
Score = 44.0 bits (99), Expect = 0.006
Identities = 121/675 (17%), Positives = 275/675 (40%), Gaps = 51/675 (7%)
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGMQRE-NRIKELEQEVARSTEVALRLQREL----AEA 499
A++L + AE +K++ + D + E +R+ E+E+ + L+ E+ A A
Sbjct: 65 AEELHKVIAEKDKQIKQT---EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALA 121
Query: 500 NSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNA 559
N + ++ L K+ Q VK + L QL ++ + +E L +Q +
Sbjct: 122 NEQAAAAH-ELEKMQQSVYVKDDKIRLLE-------EQLQHEISNKMEEFKILNDQNKAL 173
Query: 560 EEETANCKQ-VNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDS 618
+ E + V+ D + + + +TV ++ +I A+ +
Sbjct: 174 KSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRT 233
Query: 619 PPLSIDKTTEETQF--HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
S+ K ++ + + + + S+ + + + +++ E L +L K+A K +
Sbjct: 234 ENSSLTKEVQDLKAKQNDQVSFASLVEELK-KVIHEKDGKIKSVEELLEAELLKVANKEK 292
Query: 677 S-RKLSPTPPANKLSIETAN-DNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQD 734
+ + L A K I + ++ + + E++ LL+ E++ ++ +EE E+D
Sbjct: 293 TVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKD 352
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
K +++L + S+ A A+ +L S+ + +E+ L
Sbjct: 353 LANTGKWLQDLQEENESL---KAHVQEVAQHNLKEASS----------ASQFEELEIVLK 399
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSL 854
EKE + +RL E L +++ K++ L +N K Q++ ++Q+ +
Sbjct: 400 EKENELKRL--EAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 457
Query: 855 EADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQD- 913
E + + K++ L N D A++ KK L + EA+ + E + QD
Sbjct: 458 EELLKVISEREKEISGLWNELDSLKD-AVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 516
Query: 914 --EKSEKKVRFTEATKKET-DTLKS---KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDD 967
+ S+++ + EA + E + LK K + + +
Sbjct: 517 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 576
Query: 968 AQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEI 1027
K + ++ K+ ++ T LQL+ E + + E +++ S ++ K K+ ++
Sbjct: 577 EVKVLEHKL-KEADEMHTLLQLE--CEKYKSVLAETEGILQKLQRSVEQEENKWKV--KV 631
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC 1087
DE + + S FT+ + L+ ++ KD+ L +++ + + E E S +
Sbjct: 632 DESHKTIKQMQSSFTSSEQELERLRSENKDIE-NLRREREHLEMELEKAEMERSTYVTEV 690
Query: 1088 KTLTEEMKNREAQIN 1102
+ L + + + +++
Sbjct: 691 RELKDLLTELQKKLD 705
>AF026245-1|AAB86384.1| 1642|Homo sapiens yotiao protein.
Length = 1642
Score = 70.5 bits (165), Expect = 6e-11
Identities = 142/682 (20%), Positives = 289/682 (42%), Gaps = 70/682 (10%)
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR----ENRIKELEQEVARSTEVALRL 492
++ ++E Q E E+ E + + + G +G+Q+ E IK+ + + + T +
Sbjct: 170 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 229
Query: 493 QRELAEANSKF---TGSNPSLM----KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
+RE E +F T + L ++ ET++ S S T + Q+L Q
Sbjct: 230 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH-QQQ 288
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
LE + L E + +E+ Q+ +FL +++ ++E E Q+K +
Sbjct: 289 LEEQDHLLEDYQKKKEDFT--MQI---SFLQEKI--------KVYEME------QDKKVE 329
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
++ +EK K EE + +L L++ + ++ +++
Sbjct: 330 NSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 389
Query: 666 LQLKKMATKAR-SRKLSPTPPANKLSIETANDNDEK-ETDEADPAEMKLLLELNEQEATV 723
L+L K R S + ++ N D + ETD E + +L + A +
Sbjct: 390 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 449
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
+++ Q K+ L +++ +++ + G A RS + + + E+++K++
Sbjct: 450 DEMYGQQIVQMKQEL---IRQHMAQMEEMKTRHKGEMENALRSYSNIT--VNEDQIKLMN 504
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
I+E+ KL + E+L EL L ++ L R L+ DL +L ++
Sbjct: 505 VAINELNIKLQDTNSQKEKLKEELGLILEEKCAL--QRQLE-------DLVEELSFSREQ 555
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ RA+ Q++ KL +K L +++ L+++ ++K +L++E + K
Sbjct: 556 --IQRAR-QTIAEQESKLNEAHKSLSTVED---LKAEIVSASESRKELELKHEAEVTNYK 609
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
IK LEM+ + EK+ R E+ + E + L++ Q + ++
Sbjct: 610 IK-LEML-EKEKNAVLDRMAESQEAELERLRT-QLLFSHEEELSKLKEDLEIEHRINIEK 666
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED--------LECEIGEMYVVMKN-AGLSG 1014
LKD+ +K +I +++ K++ + +D L EI ++ + ++
Sbjct: 667 LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS 726
Query: 1015 KEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+EMT + +L+KEI+ +R + K E LQ + L+ + E D K+
Sbjct: 727 EEMTLQINELQKEIEILRQE-EKEKGTLEQEVQELQLKTELLEKQMKEKEND---LQEKF 782
Query: 1074 KALENENSNLSNQCKTLTEEMK 1095
LE ENS L ++ KTL + +K
Sbjct: 783 AQLEAENSILKDEKKTLEDMLK 804
Score = 61.7 bits (143), Expect = 3e-08
Identities = 130/691 (18%), Positives = 286/691 (41%), Gaps = 59/691 (8%)
Query: 267 KEYQDQIEGLKQEVDILR-KRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+++ QI L++++ + ++ ++VE + + + I+ N + L+L+ K
Sbjct: 304 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 363
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
LTT ++ L + ++ + QK +EI++ +LE S + + + E+++ + E L +
Sbjct: 364 ---LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 420
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++ ++ + + R + + Y +++Q + + + KT K
Sbjct: 421 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 480
Query: 445 ADQLEQEKA-------EHEKKLLEIVGGPDG--MQRENRIKE-LEQEVARSTEVALRLQR 494
+ ++ E + KL+ + +Q N KE L++E+ E LQR
Sbjct: 481 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 540
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L + + + S + + Q T+ S L + DL+ + ++ R+
Sbjct: 541 QLEDLVEELSFSREQIQRARQ--TIAEQESKLNEAHKS---LSTVEDLKAEIVSASESRK 595
Query: 555 QLR-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
+L E E N K +K + D + E ++ +++ + SK
Sbjct: 596 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA----ESQEAELERLRTQLLFSHEEELSK 651
Query: 614 EKSD---SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
K D ++I+K + H+ + N M+ + + E+DN
Sbjct: 652 LKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ---KIETMQFEKDN--------- 699
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEATVLRRKVE 729
+ TK +++ + L N E+ T + + + ++ +L E+E L ++V+
Sbjct: 700 LITK-QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ 758
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL-------AEERVKVL 782
EL+ E L+KQ+KE + + N+ + T + L EER+ L
Sbjct: 759 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 818
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQ---KKPKTLIKSRSLDASDQQNVDLKRQLQV 839
+ + + + EKE + + L Q + + + K R+ + ++N ++ Q ++
Sbjct: 819 DSIKSKSKDSVWEKEIEI-LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-EL 876
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENK-KLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
E+ A +L+ K LE K + E K KL+ L + L + K + + +E K
Sbjct: 877 QEEYACLLKVK-DDLEDSKNKQELEYKSKLKALN--EELHLQRINPTTVKMKSSVFDEDK 933
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKE 929
+A+ E+ + + + +E + E TK+E
Sbjct: 934 TFVAETLEMGEVXEKDTTELMEKL-EVTKRE 963
Score = 55.2 bits (127), Expect = 2e-06
Identities = 149/790 (18%), Positives = 330/790 (41%), Gaps = 65/790 (8%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT--RQIEQLRAKLLAAETL 380
+Q + TH E + E +I E+ ELE T +Q+++ A + + +
Sbjct: 159 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 218
Query: 381 CEELMD-------ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKNCR 432
+L E ++ +E +L +Q F++ QA E +LR T +
Sbjct: 219 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASE--TLRNSTHSSTAADLL 276
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ +++ ++ + +++KK + +Q + ++ E+EQ+ +V
Sbjct: 277 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----KKVENSN 332
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+ E+ E + N +++ + +T+++ + LT +LL +LQ+ + ++
Sbjct: 333 KEEIQEKETIIEELNTKIIE-EEKKTLEL-KDKLTTAD------KLLGELQEQIVQK--- 381
Query: 553 REQLRNAEEETANCKQVNPPTFLD-KQVM-TDNIVTCDIHESETVTNSIQNKMIHAASTP 610
++++N + E N KQ + + KQ+M T + H+ I +M
Sbjct: 382 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 441
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ +++ + + + Q +L I HMA KT + E +N L
Sbjct: 442 LEQLRAELDEMYGQQIVQMKQ---EL----IRQHMAQMEEMKTRHKGEMENA--LRSYSN 492
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ KL N+L+I+ + N +KE + E+ L+LE L VEE
Sbjct: 493 ITVNEDQIKLMNVA-INELNIKLQDTNSQKEKLKE---ELGLILEEKCALQRQLEDLVEE 548
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTA--RRSLTTNSNKLAEERVKVLEDEIDE 788
L +E +++ + + + S + + +T + + + S E +K E E+
Sbjct: 549 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKH-EAEVTN 607
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
+ KL E++ + ++ +Q+ ++++ L + +++ LK L+ IE ++ +
Sbjct: 608 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEK 666
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
K + K Q + + ++ + ++++ +K +L TK +N+L ++K+K+L+
Sbjct: 667 LKDNL--GIHYKQQIDGLQNEMSQKIETMQFEKD-NLITK-----QNQLILEISKLKDLQ 718
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ KSE+ +KE + L+ ++ + +K ++D
Sbjct: 719 QSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDL 778
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
Q+ F + K L+ M++ E ++ + S K + + EKEI
Sbjct: 779 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD---SIKSKSKDSVWEKEI- 834
Query: 1029 EIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
EI L + + + + +L EI K ++ + E + +V Y+ L+ E + L + K
Sbjct: 835 EI---LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLL-KVK 887
Query: 1089 TLTEEMKNRE 1098
E+ KN++
Sbjct: 888 DDLEDSKNKQ 897
Score = 50.0 bits (114), Expect = 8e-05
Identities = 128/666 (19%), Positives = 264/666 (39%), Gaps = 57/666 (8%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
E LQ+++ +L R++ + Q I E ES+L +E L+A++++A
Sbjct: 534 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN---EAHKSLSTVEDLKAEIVSA 590
Query: 378 ETLCEELMDENE----DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN-CR 432
+EL ++E + K +L L + D E Q E LR +L + +
Sbjct: 591 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 650
Query: 433 VLSFKLKKTER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
L L+ R ++L+ H K+ ++ + + E E + + + ++ L
Sbjct: 651 KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 710
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPET---VKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
+ + L + S M + E +++ R G+ E Q L+ + LE+
Sbjct: 711 ISK-LKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 769
Query: 549 -----EADLREQLRNAEEETANCKQVNPPTFLDKQVMT-----DNIVTCDIHESETVTNS 598
E DL+E+ E E + K ++ T + ++ D +S++ +S
Sbjct: 770 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKS-KDS 828
Query: 599 IQNKMIHAASTPSSKEKSDSPPLS--IDKTTEETQF---HFDLPYLSIFNHMAANNLRKT 653
+ K I + K L+ I+K F +F++ Y + A L K
Sbjct: 829 VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC--LLKV 886
Query: 654 AARVEEDNESLLLQ----LKKMATKARSRKLSPTPPANKLSIE------TANDNDEKETD 703
+E+ L+ LK + + ++++PT K S+ A + E
Sbjct: 887 KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVX 946
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
E D E+ LE+ ++E L +++ +L + + ++ L ++ S+ +
Sbjct: 947 EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKPKPGEISFLNEEVKSLKPEKEPVSLRC 1006
Query: 764 RR-SLTTNSNKL-----AEERVKVLEDEIDEVRKKLIEKE-RDCERLHAELSLAQKKPKT 816
R + N N+ + +V L D + + + E + E S + K
Sbjct: 1007 RELEIIINHNRAENVXSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV 1066
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLK 872
++ ++ +Q + L + +E+S LRA S L+ + L++E L+L
Sbjct: 1067 SFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPSENDKLQKELNVLKSEQNDLRLQM 1125
Query: 873 NAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
A+ + + + + +ENE +AL +KE + Q+EK ++ + + E
Sbjct: 1126 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL---ELQ 1182
Query: 932 TLKSKQ 937
T+K+++
Sbjct: 1183 TMKTQE 1188
Score = 44.8 bits (101), Expect = 0.003
Identities = 74/358 (20%), Positives = 155/358 (43%), Gaps = 27/358 (7%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA----AKD---VHIKQLE- 1280
EKDE F++ + L+ + + L+A + ++ ST A AK H +QLE
Sbjct: 232 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 291
Query: 1281 -DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
D L + K ++ T + ++ + + N +I+ ++T E K
Sbjct: 292 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKV--ENSNKEEIQEKETIIEELNTK 349
Query: 1340 LEMAQLKS-DLA-KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-- 1395
+ + K+ +L KL + +N EL Q ER+ + ++
Sbjct: 350 IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQL 409
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI-TELKQEYEETVKKLEHSLALE 1451
+ + +KD++ T ++ +EQ + +++ EL + Y + + +++ L +
Sbjct: 410 MGTVEELQKRNHKDSQFET--DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQ 467
Query: 1452 K-AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ-KELSTALGEIKTLQEKLG 1509
A+ EE+ +++ E + + + +TV ++Q + L++V EL+ L + + +EKL
Sbjct: 468 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK--LMNVAINELNIKLQDTNSQKEKLK 525
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
E EK +Q + L E L +++RAR + ++E +L A+ +E
Sbjct: 526 EELGLILEEKCALQRQLEDLVEELSFSREQIQRAR--QTIAEQESKLNEAHKSLSTVE 581
Score = 44.4 bits (100), Expect = 0.004
Identities = 82/447 (18%), Positives = 182/447 (40%), Gaps = 25/447 (5%)
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK- 1434
+AK+ Q + ++ D + + K ++ +++ L+ K+K+ E + + +
Sbjct: 277 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 336
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
QE E +++L + E+ + EL K ++ + ++ + ++ + L +
Sbjct: 337 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSK 396
Query: 1495 STALGEIKTLQEKLGT--ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+ +++ +GT E N + ++ + I E+ E RA L+ Q+
Sbjct: 397 QKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 456
Query: 1553 ERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+++ R+ + + + Y ++ +
Sbjct: 457 IVQMKQELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ 515
Query: 1613 XXIEQSEKARK--AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
Q EK ++ I + K + Q+ + +EL Q+ R R+ + L A K
Sbjct: 516 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 575
Query: 1671 SMA---EIKNGDKSARIHRNSISSTDEEE---YRNKVALLEQQVACLEDELCESR-LLAS 1723
S++ ++K SA R + E E Y+ K+ +LE++ + D + ES+
Sbjct: 576 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 635
Query: 1724 KLNTELV---SEKSSAEVRLAEMQSRLN-EYEEERLLSSGRARVAGLATRME-----LAW 1774
+L T+L+ E+ S E++ R+N E ++ L + ++ GL M + +
Sbjct: 636 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 695
Query: 1775 HKER--DEQQRLLQETSTLARDLRQTL 1799
K+ +Q +L+ E S L +DL+Q+L
Sbjct: 696 EKDNLITKQNQLILEISKL-KDLQQSL 721
>AC000066-1|AAC60380.1| 1620|Homo sapiens yotiao protein.
Length = 1620
Score = 70.5 bits (165), Expect = 6e-11
Identities = 142/682 (20%), Positives = 289/682 (42%), Gaps = 70/682 (10%)
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR----ENRIKELEQEVARSTEVALRL 492
++ ++E Q E E+ E + + + G +G+Q+ E IK+ + + + T +
Sbjct: 139 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 198
Query: 493 QRELAEANSKF---TGSNPSLM----KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS 545
+RE E +F T + L ++ ET++ S S T + Q+L Q
Sbjct: 199 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH-QQQ 257
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIH 605
LE + L E + +E+ Q+ +FL +++ ++E E Q+K +
Sbjct: 258 LEEQDHLLEDYQKKKEDFT--MQI---SFLQEKI--------KVYEME------QDKKVE 298
Query: 606 AASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
++ +EK K EE + +L L++ + ++ +++
Sbjct: 299 NSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK 358
Query: 666 LQLKKMATKAR-SRKLSPTPPANKLSIETANDNDEK-ETDEADPAEMKLLLELNEQEATV 723
L+L K R S + ++ N D + ETD E + +L + A +
Sbjct: 359 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 418
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
+++ Q K+ L +++ +++ + G A RS + + + E+++K++
Sbjct: 419 DEMYGQQIVQMKQEL---IRQHMAQMEEMKTRHKGEMENALRSYSNIT--VNEDQIKLMN 473
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
I+E+ KL + E+L EL L ++ L R L+ DL +L ++
Sbjct: 474 VAINELNIKLQDTNSQKEKLKEELGLILEEKCAL--QRQLE-------DLVEELSFSREQ 524
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+ RA+ Q++ KL +K L +++ L+++ ++K +L++E + K
Sbjct: 525 --IQRAR-QTIAEQESKLNEAHKSLSTVED---LKAEIVSASESRKELELKHEAEVTNYK 578
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
IK LEM+ + EK+ R E+ + E + L++ Q + ++
Sbjct: 579 IK-LEML-EKEKNAVLDRMAESQEAELERLRT-QLLFSHEEELSKLKEDLEIEHRINIEK 635
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED--------LECEIGEMYVVMKN-AGLSG 1014
LKD+ +K +I +++ K++ + +D L EI ++ + ++
Sbjct: 636 LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS 695
Query: 1015 KEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+EMT + +L+KEI+ +R + K E LQ + L+ + E D K+
Sbjct: 696 EEMTLQINELQKEIEILRQE-EKEKGTLEQEVQELQLKTELLEKQMKEKEND---LQEKF 751
Query: 1074 KALENENSNLSNQCKTLTEEMK 1095
LE ENS L ++ KTL + +K
Sbjct: 752 AQLEAENSILKDEKKTLEDMLK 773
Score = 62.1 bits (144), Expect = 2e-08
Identities = 130/691 (18%), Positives = 286/691 (41%), Gaps = 59/691 (8%)
Query: 267 KEYQDQIEGLKQEVDILR-KRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+++ QI L++++ + ++ ++VE + + + I+ N + L+L+ K
Sbjct: 273 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 332
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIES-ELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
LTT ++ L + ++ + QK +EI++ +LE S + + + E+++ + E L +
Sbjct: 333 ---LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 389
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
+++ ++ + + R + + Y +++Q + + + KT K
Sbjct: 390 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 449
Query: 445 ADQLEQEKA-------EHEKKLLEIVGGPDG--MQRENRIKE-LEQEVARSTEVALRLQR 494
+ ++ E + KL+ + +Q N KE L++E+ E LQR
Sbjct: 450 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 509
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
+L + + + S + + Q T+ S L + DL+ + ++ R+
Sbjct: 510 QLEDLVEELSFSREQIQRARQ--TIAEQESKLNEAHKS---LSTVEDLKAEIVSASESRK 564
Query: 555 QLR-NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
+L E E N K +K + D + E ++ +++ + SK
Sbjct: 565 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA----ESQEAELERLRTQLLFSHEEELSK 620
Query: 614 EKSD---SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
K D ++I+K + H+ + N M+ + + E+DN
Sbjct: 621 LKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ---KIETMQFEKDN--------- 668
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL-LLELNEQEATVLRRKVE 729
+ TK +++ + L N E+ T + + + ++ +L E+E L ++V+
Sbjct: 669 LITK-QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ 727
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL-------AEERVKVL 782
EL+ E L+KQ+KE + + N+ + T + L EER+ L
Sbjct: 728 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 787
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQ---KKPKTLIKSRSLDASDQQNVDLKRQLQV 839
+ + + + EKE + + L Q + + + K R+ + ++N ++ Q ++
Sbjct: 788 DSIKSKSKDSVWEKEIEI-LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-EL 845
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENK-KLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
E+ A +L+ K LE K + E K KL+ L + L + K + + +E K
Sbjct: 846 QEEYACLLKVK-DDLEDSKNKQELEYKSKLKALN--EELHLQRINPTTVKMKSSVFDEDK 902
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKE 929
+A+ E+ + + + +E + E TK+E
Sbjct: 903 TFVAETLEMGEVVEKDTTELMEKL-EVTKRE 932
Score = 55.2 bits (127), Expect = 2e-06
Identities = 149/790 (18%), Positives = 330/790 (41%), Gaps = 65/790 (8%)
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT--RQIEQLRAKLLAAETL 380
+Q + TH E + E +I E+ ELE T +Q+++ A + + +
Sbjct: 128 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 187
Query: 381 CEELMD-------ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQ-TIKNCR 432
+L E ++ +E +L +Q F++ QA E +LR T +
Sbjct: 188 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASE--TLRNSTHSSTAADLL 245
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
++ +++ ++ + +++KK + +Q + ++ E+EQ+ +V
Sbjct: 246 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----KKVENSN 301
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADL 552
+ E+ E + N +++ + +T+++ + LT +LL +LQ+ + ++
Sbjct: 302 KEEIQEKETIIEELNTKIIE-EEKKTLEL-KDKLTTAD------KLLGELQEQIVQK--- 350
Query: 553 REQLRNAEEETANCKQVNPPTFLD-KQVM-TDNIVTCDIHESETVTNSIQNKMIHAASTP 610
++++N + E N KQ + + KQ+M T + H+ I +M
Sbjct: 351 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 410
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+ +++ + + + Q +L I HMA KT + E +N L
Sbjct: 411 LEQLRAELDEMYGQQIVQMKQ---EL----IRQHMAQMEEMKTRHKGEMENA--LRSYSN 461
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
+ KL N+L+I+ + N +KE + E+ L+LE L VEE
Sbjct: 462 ITVNEDQIKLMNVA-INELNIKLQDTNSQKEKLKE---ELGLILEEKCALQRQLEDLVEE 517
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTA--RRSLTTNSNKLAEERVKVLEDEIDE 788
L +E +++ + + + S + + +T + + + S E +K E E+
Sbjct: 518 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKH-EAEVTN 576
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
+ KL E++ + ++ +Q+ ++++ L + +++ LK L+ IE ++ +
Sbjct: 577 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEK 635
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELE 908
K + K Q + + ++ + ++++ +K +L TK +N+L ++K+K+L+
Sbjct: 636 LKDNL--GIHYKQQIDGLQNEMSQKIETMQFEKD-NLITK-----QNQLILEISKLKDLQ 687
Query: 909 MICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA 968
+ KSE+ +KE + L+ ++ + +K ++D
Sbjct: 688 QSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDL 747
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEID 1028
Q+ F + K L+ M++ E ++ + S K + + EKEI
Sbjct: 748 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD---SIKSKSKDSVWEKEI- 803
Query: 1029 EIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
EI L + + + + +L EI K ++ + E + +V Y+ L+ E + L + K
Sbjct: 804 EI---LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLL-KVK 856
Query: 1089 TLTEEMKNRE 1098
E+ KN++
Sbjct: 857 DDLEDSKNKQ 866
Score = 50.0 bits (114), Expect = 8e-05
Identities = 128/666 (19%), Positives = 265/666 (39%), Gaps = 57/666 (8%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA 377
E LQ+++ +L R++ + Q I E ES+L +E L+A++++A
Sbjct: 503 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN---EAHKSLSTVEDLKAEIVSA 559
Query: 378 ETLCEELMDENE----DMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN-CR 432
+EL ++E + K +L L + D E Q E LR +L + +
Sbjct: 560 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 619
Query: 433 VLSFKLKKTER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
L L+ R ++L+ H K+ ++ + + E E + + + ++ L
Sbjct: 620 KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 679
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPET---VKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
+ + L + S M + E +++ R G+ E Q L+ + LE+
Sbjct: 680 ISK-LKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 738
Query: 549 -----EADLREQLRNAEEETANCKQVNPPTFLDKQVMT-----DNIVTCDIHESETVTNS 598
E DL+E+ E E + K ++ T + ++ D +S++ +S
Sbjct: 739 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKS-KDS 797
Query: 599 IQNKMIHAASTPSSKEKSDSPPLS--IDKTTEETQF---HFDLPYLSIFNHMAANNLRKT 653
+ K I + K L+ I+K F +F++ Y + A L K
Sbjct: 798 VWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC--LLKV 855
Query: 654 AARVEEDNESLLLQ----LKKMATKARSRKLSPTPPANKLSIE------TANDNDEKETD 703
+E+ L+ LK + + ++++PT K S+ A + E
Sbjct: 856 KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVV 915
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
E D E+ LE+ ++E L +++ +L + + ++ L ++ S+ + +
Sbjct: 916 EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRC 975
Query: 764 RR-SLTTNSNKL-----AEERVKVLEDEIDEVRKKLIEKE-RDCERLHAELSLAQKKPKT 816
R + N N+ + +V L D + + + E + E S + K
Sbjct: 976 RELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV 1035
Query: 817 LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLK 872
++ ++ +Q + L + +E+S LRA S L+ + L++E L+L
Sbjct: 1036 SFENMTVGEESKQEQLILDHLPSVTKESS-LRATQPSENDKLQKELNVLKSEQNDLRLQM 1094
Query: 873 NAKSLRSDKALDLNTKKTTQ-LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
A+ + + + + +ENE +AL +KE + Q+EK ++ + + E
Sbjct: 1095 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL---ELQ 1151
Query: 932 TLKSKQ 937
T+K+++
Sbjct: 1152 TMKTQE 1157
Score = 44.8 bits (101), Expect = 0.003
Identities = 74/358 (20%), Positives = 155/358 (43%), Gaps = 27/358 (7%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA----AKD---VHIKQLE- 1280
EKDE F++ + L+ + + L+A + ++ ST A AK H +QLE
Sbjct: 201 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE 260
Query: 1281 -DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
D L + K ++ T + ++ + + N +I+ ++T E K
Sbjct: 261 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKV--ENSNKEEIQEKETIIEELNTK 318
Query: 1340 LEMAQLKS-DLA-KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMR-- 1395
+ + K+ +L KL + +N EL Q ER+ + ++
Sbjct: 319 IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQL 378
Query: 1396 ---IAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI-TELKQEYEETVKKLEHSLALE 1451
+ + +KD++ T ++ +EQ + +++ EL + Y + + +++ L +
Sbjct: 379 MGTVEELQKRNHKDSQFET--DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQ 436
Query: 1452 K-AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ-KELSTALGEIKTLQEKLG 1509
A+ EE+ +++ E + + + +TV ++Q + L++V EL+ L + + +EKL
Sbjct: 437 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK--LMNVAINELNIKLQDTNSQKEKLK 494
Query: 1510 TESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLE 1567
E EK +Q + L E L +++RAR + ++E +L A+ +E
Sbjct: 495 EELGLILEEKCALQRQLEDLVEELSFSREQIQRAR--QTIAEQESKLNEAHKSLSTVE 550
Score = 44.4 bits (100), Expect = 0.004
Identities = 82/447 (18%), Positives = 182/447 (40%), Gaps = 25/447 (5%)
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK- 1434
+AK+ Q + ++ D + + K ++ +++ L+ K+K+ E + + +
Sbjct: 246 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 305
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
QE E +++L + E+ + EL K ++ + ++ + ++ + L +
Sbjct: 306 QEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSK 365
Query: 1495 STALGEIKTLQEKLGT--ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+ +++ +GT E N + ++ + I E+ E RA L+ Q+
Sbjct: 366 QKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 425
Query: 1553 ERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXX 1612
+++ R+ + + + Y ++ +
Sbjct: 426 IVQMKQELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ 484
Query: 1613 XXIEQSEKARK--AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
Q EK ++ I + K + Q+ + +EL Q+ R R+ + L A K
Sbjct: 485 DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHK 544
Query: 1671 SMA---EIKNGDKSARIHRNSISSTDEEE---YRNKVALLEQQVACLEDELCESR-LLAS 1723
S++ ++K SA R + E E Y+ K+ +LE++ + D + ES+
Sbjct: 545 SLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 604
Query: 1724 KLNTELV---SEKSSAEVRLAEMQSRLN-EYEEERLLSSGRARVAGLATRME-----LAW 1774
+L T+L+ E+ S E++ R+N E ++ L + ++ GL M + +
Sbjct: 605 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 664
Query: 1775 HKER--DEQQRLLQETSTLARDLRQTL 1799
K+ +Q +L+ E S L +DL+Q+L
Sbjct: 665 EKDNLITKQNQLILEISKL-KDLQQSL 690
>BC039612-1|AAH39612.1| 2002|Homo sapiens MYO18A protein protein.
Length = 2002
Score = 70.1 bits (164), Expect = 7e-11
Identities = 156/755 (20%), Positives = 303/755 (40%), Gaps = 75/755 (9%)
Query: 299 LRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETR 357
+R L + + + + E+ +L+ K+ + +LR L +I E+ SEL + R
Sbjct: 1243 VRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 1302
Query: 358 PSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDL------XXXXXXMQDNFRE 411
+ E+ ++ ++ A+ L AE +EL + + +KK++ + + N
Sbjct: 1303 NTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEV 1362
Query: 412 DQADEYSSLRRELEQTIKNCRVLSFKLKKT-ERKADQLEQEKAEHEKKLLEIVGGPDGMQ 470
D D R + E+ ++ +L++ E K + +Q K + E++L ++ D +
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQA--DSEE 1420
Query: 471 RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGG 530
+ +++L+++ RL EL + G +V E K R +
Sbjct: 1421 SQRALQQLKKK-------CQRLTAELQDTKLHLEG-----QQVRNHELEKKQRRFDSELS 1468
Query: 531 SQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
+ AQ + ++ L+RE D+ E + KQ +D T +V+
Sbjct: 1469 QAHEEAQREKLQREKLQREKDM------LLAEAFSLKQQLEEKDMDIAGFTQKVVSL--- 1519
Query: 591 ESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL 650
E+E S Q A+ K+ D ++ ++ + D +I L
Sbjct: 1520 EAELQDISSQESKDEASLAKVKKQLRD-----LEAKVKDQEEELDEQAGTI---QMLEQL 1571
Query: 651 RKTAARVEEDNESLLLQLK-KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE 709
++ ++EE+ E L+ K + + LS E D K T +A A+
Sbjct: 1572 KQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRT-KALLAD 1630
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
+L+L+ + A R E+ Q LK Q++E ++ K L
Sbjct: 1631 AQLMLDHLKNSAPSKR----EIAQ----LKNQLEESEFTCAAAVKARKAMEVEI-EDLHL 1681
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
+ +A+ + LE+++ ++++ E + E +++ KK K + S D + Q
Sbjct: 1682 QIDDIAKAKT-ALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLA--Q 1738
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKNAKSLRSDKALDL-- 885
DL+ QL+ +E L+ K Q+L++ E L+ +K L + AK + L+
Sbjct: 1739 INDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFER 1798
Query: 886 -NTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K+ L + LKE + K+ E +D++ + R E K+ L+ +
Sbjct: 1799 TQVKRLESLASRLKENMEKLTEE----RDQRIAAENREKEQNKRLQRQLRDTKEEMGELA 1854
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
+ L+SL + A +S + DL KL K+ + DL+ I +
Sbjct: 1855 RKEAEASRKKHELEMDLESL-EAANQSLQ-------ADL--KLAFKR-IGDLQAAIEDEM 1903
Query: 1005 VVMKNAGLSGKE--MTAKTKLEKEIDEIRSKLSKN 1037
+N L E ++LE +D ++S LSKN
Sbjct: 1904 ESDENEDLINSEGDSDVDSELEDRVDGVKSWLSKN 1938
Score = 68.5 bits (160), Expect = 2e-10
Identities = 143/702 (20%), Positives = 303/702 (43%), Gaps = 88/702 (12%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEK------SDILLRRLANI-----------DTANKYT 312
++QI +E+ LR + E+ EKE+ SD L R++ + ++A++
Sbjct: 1253 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLL 1312
Query: 313 TGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKI--------REIESELETRPS-TEAQ 363
++E L+ ++++ EL T + L+ + + + ++ EI E++ + E +
Sbjct: 1313 DAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWR 1372
Query: 364 TRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ------ADEY 417
+ +R + L +E D+ E ++ R L +Q + E Q +
Sbjct: 1373 LKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKC 1432
Query: 418 SSLRRELEQT---IKNCRVLSFKLKKTERKAD-QLEQ--EKAEHEKKLLEIVGGPDGM-- 469
L EL+ T ++ +V + +L+K +R+ D +L Q E+A+ EK E + M
Sbjct: 1433 QRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLL 1492
Query: 470 ----QRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ-----PETVK 520
+ +++E + ++A T+ + L+ EL + +S+ + SL KV + VK
Sbjct: 1493 AEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVK 1552
Query: 521 VSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVM 580
L + L+ ++ LE E + ++++ + E +
Sbjct: 1553 DQEEELDEQAGTIQMLEQLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFE 1612
Query: 581 TDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLS 640
++ + D+ ++ + Q + H ++ SK + + EE++
Sbjct: 1613 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREI----AQLKNQLEESE--------- 1659
Query: 641 IFNHMAANNLRKTAARVEEDNESLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDE 699
F AA RK +E + E L LQ+ +A K + K I+ + D+
Sbjct: 1660 -FTCAAAVKARKA---MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQ 1715
Query: 700 KETDEADPAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKI-----SSV 752
++ +E + + + A + L+ ++EE ++K+ L+++++ L S++ S V
Sbjct: 1716 EDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMV 1775
Query: 753 TKTSAGSNTTARRSLTT--NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
K+ R L T + +R++ L + E +KL E ERD +R+ AE
Sbjct: 1776 DKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTE-ERD-QRIAAE---N 1830
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE----NK 866
++K + R L + ++ +L R+ ++ L +SLEA N+ LQ + K
Sbjct: 1831 REKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFK 1890
Query: 867 KLQLLKNA--KSLRSDKALDL-NTKKTTQLENELKEALAKIK 905
++ L+ A + SD+ DL N++ + +++EL++ + +K
Sbjct: 1891 RIGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVDGVK 1932
Score = 65.3 bits (152), Expect = 2e-09
Identities = 129/693 (18%), Positives = 295/693 (42%), Gaps = 71/693 (10%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEV 319
D +++ + ++E ++E + LR +R+E S++ L ++A++ ++E
Sbjct: 1260 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAER 1319
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIRE--------IESELETRPST-EAQTRQIEQL 370
L+ ++++ EL T + L+ + + + ++ E I E++ + E + + +
Sbjct: 1320 LRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAV 1379
Query: 371 RAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQA------DEYSSLRREL 424
R + L +E D+ E ++ R L +Q + E Q + L EL
Sbjct: 1380 REVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAEL 1439
Query: 425 EQT---IKNCRVLSFKLKKTERKAD-QLEQ--EKAEHEKKLLEIVGGPDGM------QRE 472
+ T ++ +V + +L+K +R+ D +L Q E+A+ EK E + M +
Sbjct: 1440 QDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLK 1499
Query: 473 NRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP-----ETVKVSRSSLT 527
+++E + ++A T+ + L+ EL + +S+ + SL KV + VK L
Sbjct: 1500 QQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELD 1559
Query: 528 RGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTC 587
+ L+ ++ LE E + ++++ + E + ++ +
Sbjct: 1560 EQAGTIQMLEQLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRK 1619
Query: 588 DIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAA 647
D+ ++ + Q + H ++ SK + + EE++F AA
Sbjct: 1620 DLKRTKALLADAQLMLDHLKNSAPSKREI----AQLKNQLEESEF----------TCAAA 1665
Query: 648 NNLRKTAARVEEDNESLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKETDEAD 706
RK +E + E L LQ+ +A K + K I+ + D+++ +E
Sbjct: 1666 VKARKA---MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELM 1722
Query: 707 PAEMKLLLELNEQEATV--LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
+ + + A + L+ ++EE ++K+ L+++++ L S++ + ++ + +R
Sbjct: 1723 KKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSR 1782
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
+ E +++ LE ++ R ++ E RL + ++ I + + +
Sbjct: 1783 Q----------EAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENRE 1832
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
+QN L+RQL+ ++E L K EA +K + E L +SL++D L
Sbjct: 1833 K--EQNKRLQRQLRDTKEEMGELARK--EAEASRKKHELEMDLESLEAANQSLQAD--LK 1886
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSE 917
L K+ L+ +++ + + ++I + S+
Sbjct: 1887 LAFKRIGDLQAAIEDEMESDENEDLINSEGDSD 1919
Score = 61.7 bits (143), Expect = 3e-08
Identities = 121/597 (20%), Positives = 246/597 (41%), Gaps = 60/597 (10%)
Query: 1222 LSIELTSEKD--ELQARFIKTES-KFITLEAEMRDLKADYENKITSLE---------STI 1269
L+ ELT E++ E ++ + E+ + + E EM++L+ Y+ +E I
Sbjct: 1294 LTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLI 1353
Query: 1270 AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLE 1329
A +++ + +D KY+ A V+ + R Q++ + +L
Sbjct: 1354 RAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNK-RQLERRLG 1412
Query: 1330 KTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERK 1389
+A+S ++ + QLK +L + E K + D++L +
Sbjct: 1413 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHE 1472
Query: 1390 KLDRMRIAHDKDVKNKD---AELATLKGKLKILEQNSGAGAKRITELKQEYEE---TVKK 1443
+ R ++ +K + KD AE +LK +L+ + + +++ L+ E ++ K
Sbjct: 1473 EAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532
Query: 1444 LEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKT 1503
E SLA K + +L K + EEE ++++ ++L K++ L E
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEE---------LDEQAGTIQMLEQLKQMEVQLEEEYE 1583
Query: 1504 LQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRR 1563
++K+ EK E++ +A+L +++ +E E+ RL L +R + L A D +
Sbjct: 1584 DKQKV-------LREKRELEGKLATLSDQVNRRDFESEK-RLRKDL-KRTKALLA--DAQ 1632
Query: 1564 DVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
+L+H + E I+ KA+
Sbjct: 1633 LMLDHLKN-SAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKT 1691
Query: 1624 AEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSAR 1683
A + + +R + + N +++ L+ ++ ++ +K + A + +A+I D A+
Sbjct: 1692 A-LEEQLSRLQREKNEIQNRLEEDQEDMNELMKK---HKAAVAQASRDLAQI--NDLQAQ 1745
Query: 1684 IHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLA------SKLNTELVSEKSSAE 1737
+ ++ +++E + K+ L+ QV LE + + L++ +L T L E++ +
Sbjct: 1746 LEE---ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVK 1802
Query: 1738 VRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQR-LLQETSTLAR 1793
RL + SRL E E+L R+A A E +K Q R +E LAR
Sbjct: 1803 -RLESLASRLKE-NMEKLTEERDQRIA--AENREKEQNKRLQRQLRDTKEEMGELAR 1855
Score = 61.7 bits (143), Expect = 3e-08
Identities = 104/470 (22%), Positives = 190/470 (40%), Gaps = 28/470 (5%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK 711
+TA R+ + E LQ + A K + + +L I A N E + D+A E +
Sbjct: 1315 ETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARL-IRAAEINGEVDDDDAG-GEWR 1372
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNS 771
L E +E ++++++ +DK +++Q K + + + + A + L
Sbjct: 1373 LKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKC 1432
Query: 772 NKL-AEERVKVLEDEIDEVRKKLIEKER---DCERLHAELSLAQKKPKTLIKSRSLDASD 827
+L AE + L E +VR +EK++ D E A ++K + R D
Sbjct: 1433 QRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLL 1492
Query: 828 QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKK--LQLLKNAKSLRSDKALDL 885
+ LK+QL+ + + + K SLEA+ + + ++ K L K K LR DL
Sbjct: 1493 AEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR-----DL 1547
Query: 886 NTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXX 945
K Q E EL E I+ LE + Q E V+ E + + L+ K+
Sbjct: 1548 EAKVKDQ-EEELDEQAGTIQMLEQLKQME-----VQLEEEYEDKQKVLREKRELEGKLAT 1601
Query: 946 XXXXXXXXXXXXQATL-KSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
+ L K LK K+ L K+ + L+ ++ E
Sbjct: 1602 LSDQVNRRDFESEKRLRKDLK--RTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE 1659
Query: 1005 VVMKNAGLSGKEMTAKTK-LEKEIDEI---RSKLSKNDSEFTNEKNRLQTEIAK-LKDVN 1059
A + K M + + L +ID+I ++ L + S EKN +Q + + +D+N
Sbjct: 1660 FTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMN 1719
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
++ K A + L N +L Q + +E + + ++ L + ++
Sbjct: 1720 ELMKKHKAAVAQASRDLAQIN-DLQAQLEEANKEKQELQEKLQALQSQVE 1768
Score = 60.5 bits (140), Expect = 6e-08
Identities = 123/687 (17%), Positives = 260/687 (37%), Gaps = 46/687 (6%)
Query: 834 KRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ- 892
+ Q++ ++E LR+K + E + +L+ + +L+ L S+ + NT ++
Sbjct: 1253 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLE--SRISELTSELTDERNTGESASQ 1310
Query: 893 -LENELKEALAKIKEL-EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXX 950
L+ E E L KE+ E+ Q + +K++ E E +++ +
Sbjct: 1311 LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGE 1370
Query: 951 XXXXXXXQAT-LKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ K Q+ F+ ++ + K QL++ + DL+ + E ++
Sbjct: 1371 WRLKYERAVREVDFTKKRLQQEFEDKLE---VEQQNKRQLERRLGDLQADSEESQRALQQ 1427
Query: 1010 AGLSGKEMTAK---TKLEKEIDEIRS-KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
+ +TA+ TKL E ++R+ +L K F +E ++ E + K KL+ +
Sbjct: 1428 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1487
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA-DLKNATSLQTTMSDCMXX 1124
KD+ + +L+ + T+++ + EA++ +S+ + K+ SL
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDL 1547
Query: 1125 XXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXC 1184
+ ++ Q + +L +E DK K + +
Sbjct: 1548 EAKVKDQEEELDEQAGT----IQMLEQLKQMEVQLEEEYEDKQKVLREKRELEGKLATLS 1603
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
++ ++ + R+ A ++ + H + S E +L+ + ++E
Sbjct: 1604 DQVNRRDFESEKRLRKDLKRTKALLADAQLMLD-HLKNSAPSKREIAQLKNQLEESEFTC 1662
Query: 1245 ITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMR 1304
+ ++ + E+ ++ AK +QL R+ + +M E+
Sbjct: 1663 AAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELM 1722
Query: 1305 XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXX 1364
++N+ + +LE+ E + ++ L+S + LE
Sbjct: 1723 KKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLV-- 1780
Query: 1365 XXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSG 1424
S E K +EL+T L+ ER ++ R+ + +N + K+ E+
Sbjct: 1781 ------SRQEAKIRELETRLEFERTQVKRLESLASRLKENME----------KLTEERD- 1823
Query: 1425 AGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQ 1484
+RI +E E+ K+L+ L K E EL K E E K L ++ E +
Sbjct: 1824 ---QRIAAENREKEQN-KRLQRQLRDTKEEMGELARK----EAEASRKKHELEMDLESLE 1875
Query: 1485 GELLHVQKELSTALGEIKTLQEKLGTE 1511
+Q +L A I LQ + E
Sbjct: 1876 AANQSLQADLKLAFKRIGDLQAAIEDE 1902
Score = 56.0 bits (129), Expect = 1e-06
Identities = 104/506 (20%), Positives = 210/506 (41%), Gaps = 60/506 (11%)
Query: 658 EEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELN 717
+E+ + L +L+K + +L+ +++S T+ DE+ T E+ LL+
Sbjct: 1260 DEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGES----ASQLLDAE 1315
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKI------------SSVTKTSAGSN----- 760
E ++++EL+ +ALKKQ++ + ++ V AG
Sbjct: 1316 TAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKY 1375
Query: 761 TTARRSLTTNSNKLA---EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTL 817
A R + +L E++++V + ++ ++L + + D E L +KK + L
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRL 1435
Query: 818 ---IKSRSLDASDQQ--NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLK 872
++ L QQ N +L+++ + + E S + Q + EKLQ E K LL
Sbjct: 1436 TAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE--KDMLLA 1493
Query: 873 NAKSLR---SDKALDLN--TKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
A SL+ +K +D+ T+K LE EL++ ++ + E K +K++R EA
Sbjct: 1494 EAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDE--ASLAKVKKQLRDLEAKV 1551
Query: 928 KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSF--KPRIPKKPTDLTT 985
K+ + +Q + L+ +D QK K + K L+
Sbjct: 1552 KDQEEELDEQ-------AGTIQMLEQLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSD 1604
Query: 986 KLQLKKMVED--LECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFT- 1042
++ + + L ++ ++ +A L + ++EI +++++L +SEFT
Sbjct: 1605 QVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQL--EESEFTC 1662
Query: 1043 ----NEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC----KTLTEEM 1094
+ ++ EI L + K + L+ E + + N+ + + E M
Sbjct: 1663 AAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELM 1722
Query: 1095 KNREAQINKLSADLKNATSLQTTMSD 1120
K +A + + S DL LQ + +
Sbjct: 1723 KKHKAAVAQASRDLAQINDLQAQLEE 1748
Score = 54.8 bits (126), Expect = 3e-06
Identities = 76/398 (19%), Positives = 162/398 (40%), Gaps = 22/398 (5%)
Query: 95 KKDTFSTGFNKNNTSWTST-PDLGADGSDSNAVTVNLKLPKRRLTGPLPD----LDTGQT 149
+KD GF + S + D+ + S A +K R L + D LD
Sbjct: 1504 EKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAG 1563
Query: 150 TNGSQTQLAITKNDSLAERVRKMQLLKTQNSFE-KEPSIEKERERRSLSKSKEDEKTARY 208
T QL + E K ++L+ + E K ++ + RR E EK R
Sbjct: 1564 TIQMLEQLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDF----ESEKRLR- 1618
Query: 209 KDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKE 268
KD + + + + + + +NS K + ++ +++
Sbjct: 1619 KDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIED 1678
Query: 269 YQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ---K 325
QI+ + + L ++ R+++EK++I R + + N+ + V + + +
Sbjct: 1679 LHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1738
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
+N+L E+ EK+ L +K++ ++S++E + + + AK+ ET L
Sbjct: 1739 INDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELET---RLE 1795
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
E +K+ L L + E++ ++ RE EQ + L +L+ T+ +
Sbjct: 1796 FERTQVKR-LESLASRLKENMEKLTEERDQRIAAENREKEQN----KRLQRQLRDTKEEM 1850
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVA 483
+L +++AE +K E+ + ++ N+ + + ++A
Sbjct: 1851 GELARKEAEASRKKHELEMDLESLEAANQSLQADLKLA 1888
Score = 52.0 bits (119), Expect = 2e-05
Identities = 88/464 (18%), Positives = 190/464 (40%), Gaps = 27/464 (5%)
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
E+++ L QLKK + ++L+ KL +E + E + + + EL++
Sbjct: 1419 EESQRALQQLKK-----KCQRLTAELQDTKLHLE----GQQVRNHELEKKQRRFDSELSQ 1469
Query: 719 QEATVLRRKV--EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
R K+ E+L+++K+ L + L ++ AG T SL ++
Sbjct: 1470 AHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGF-TQKVVSLEAELQDISS 1528
Query: 777 ERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ 836
+ K E + +V+K+L + E + EL + L + + ++ ++ + K++
Sbjct: 1529 QESKD-EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQLKQMEVQLEEEYEDKQK 1587
Query: 837 LQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN-TKKTTQLEN 895
+ ++E A T S + + ++E + + LK K+L +D L L+ K + +
Sbjct: 1588 VLREKRELEGKLA-TLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKR 1646
Query: 896 ELKEALAKIKELEMICQDEKSEKK---VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXX 952
E+ + +++E E C +K V + + D K+K
Sbjct: 1647 EIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNE 1706
Query: 953 XXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY----VVMK 1008
+ + + ++ K K + + DL L+ +E+ E E+ +
Sbjct: 1707 IQNRLEEDQEDM-NELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQS 1765
Query: 1009 NAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDV 1068
+ M K+ + ++ +IR ++ + E T K RL++ ++LK+ KL ++D
Sbjct: 1766 QVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVK-RLESLASRLKENMEKLTEERDQ 1824
Query: 1069 FANKYKALENENSNLSNQCKTLTEEM---KNREAQINKLSADLK 1109
+ +N L Q + EEM +EA+ ++ +L+
Sbjct: 1825 RIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELE 1868
Score = 49.6 bits (113), Expect = 1e-04
Identities = 55/334 (16%), Positives = 145/334 (43%), Gaps = 22/334 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLA---NIDTANKYTTGRSSE 318
++ + + ++ +E + + E++++EK +L + ++ + G + +
Sbjct: 1456 LEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQK 1515
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
V+ L+ ++ ++++ + +++R++E++++ + + Q+ +L E
Sbjct: 1516 VVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQLKQME 1575
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQT---IKNCRVLS 435
EE ++ + + +E R+L + D + LR++L++T + + +++
Sbjct: 1576 VQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLML 1635
Query: 436 FKLKK---TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-- 490
LK ++R+ QL+ + E E V M+ E L+ + + AL
Sbjct: 1636 DHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEE 1695
Query: 491 ---RLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
RLQRE E ++ + ++ + V+++S D AQ + DLQ LE
Sbjct: 1696 QLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQAS-------RDLAQ-INDLQAQLE 1747
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQVMT 581
+++L+ + + + + +DK +++
Sbjct: 1748 EANKEKQELQEKLQALQSQVEFLEQSMVDKSLVS 1781
Score = 40.3 bits (90), Expect = 0.069
Identities = 106/585 (18%), Positives = 215/585 (36%), Gaps = 59/585 (10%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
E++EL+ + ES+ L +E+ D + E+ L++ A + K++++ Q
Sbjct: 1276 ERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDA 1335
Query: 1289 DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
K +E++E R D ++K E+ E K + Q D
Sbjct: 1336 LKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFED 1395
Query: 1349 LAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAE 1408
++E E + +L D + ++ L +++ K + AE
Sbjct: 1396 KLEVEQQNKRQL-------------ERRLGDLQADSEESQRALQQLK----KKCQRLTAE 1438
Query: 1409 LATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEE 1468
L K L+ + + K+ ++ ++ + + EK + E+L + ++L E
Sbjct: 1439 LQDTKLHLEGQQVRNHELEKK----QRRFDSELSQAHEEAQREKLQREKLQREKDMLLAE 1494
Query: 1469 HVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIAS 1528
K +L EK+ L L +I + + K A + +++ +
Sbjct: 1495 AFSLKQQLE-EKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKD 1553
Query: 1529 LQERLCGGGWEVERARLNARLDQRERELRAA-NDRRDVLEHHHDXXXXXXXXXXXXXX-D 1586
+E L ++ +L Q E +L D++ VL + D
Sbjct: 1554 QEEELDEQAGTIQMLE---QLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRD 1610
Query: 1587 YERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNT------- 1639
+E ++++ ++ K EI K + E T
Sbjct: 1611 FESEKRLRKDLKRTKALLADAQLMLDHL--KNSAPSKREIAQLKNQLEESEFTCAAAVKA 1668
Query: 1640 ---MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEE 1696
M E++ LH Q+ + + ++ L Q+ EI+N R+ D+E+
Sbjct: 1669 RKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQN-----RLEE------DQED 1717
Query: 1697 YRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYE----E 1752
+ + VA +L + L ++L E EK + +L +QS++ E +
Sbjct: 1718 MNELMKKHKAAVAQASRDLAQINDLQAQLE-EANKEKQELQEKLQALQSQVEFLEQSMVD 1776
Query: 1753 ERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+ L+S A++ L TR+E ER + +RL S L ++ +
Sbjct: 1777 KSLVSRQEAKIRELETRLEF----ERTQVKRLESLASRLKENMEK 1817
>AF485338-1|AAL93149.1| 1498|Homo sapiens golgin-160 protein.
Length = 1498
Score = 70.1 bits (164), Expect = 7e-11
Identities = 176/877 (20%), Positives = 356/877 (40%), Gaps = 72/877 (8%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q + + L EVD L++ C +E+ +D L+ + ++ N ++++ +++ L
Sbjct: 460 QQRQDSLSSEVDTLKQSCWDLERAMTD--LQNM--LEAKNASLASSNNDLQVAEEQYQRL 515
Query: 330 TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ--LRAKLLAAETLCEELMDE 387
ED++ + ++ ++ T ++ Q Q+E+ L +KL A++ L
Sbjct: 516 MAKVEDMQRSMLSKDNTVHDLRQQM-TALQSQLQQVQLERTTLTSKLKASQAEISSLQSV 574
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
+ +++L +Q Q + + ++N LS +L +T+ ++
Sbjct: 575 RQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVS-LSQQLTETQHRS-- 631
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSN 507
+EK +L I D + +E ++++ T V LQR L E F G
Sbjct: 632 -MKEKGRIAAQLQGIEA--DMLDQEAAFMQIQEA---KTMVEEDLQRRLEE----FEGER 681
Query: 508 PSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLERE-ADLREQLRNAEEETAN 565
L ++ S +SL + Q L RD Q ++L++E DL +QL +E +
Sbjct: 682 ERLQRMAD------SAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQS 735
Query: 566 CKQVNPP--TFLDKQVMTDNIVTCDIHESETVTNSIQNKMI--HAA--STPSSKEKSDSP 619
+Q T D+ + + E +QN+ I AA + S KE+ D
Sbjct: 736 REQSLDALQTRYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRG 795
Query: 620 PLSIDKTTEETQFHFDL--PYLSIFNHMAANNLRKTAARVEEDNE--SLLLQLKKMATKA 675
+++ TEET + L+I + + ++TAA ++ + LQ K M
Sbjct: 796 ARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAY 855
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
R S ++L + E + + ++ E E + L R+V ++ Q
Sbjct: 856 RRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHM 915
Query: 736 EALKKQVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L+ ++ + V T + + T +N+ +++++ L+ E RK +
Sbjct: 916 ADLEGHLQSAQKERDEVETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE---ARKAIT 972
Query: 795 EKERDCERLHAELSLAQKKPKTLIKS--RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
E+++ RL ++L+ AQK+ KT K+ ++ ++ + + + E LRA+
Sbjct: 973 EQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAREAADAELGQLRAQGG 1032
Query: 853 SLEAD---NEKLQTENKKLQLLKNAKSLR----------SDKALDLNTKKTTQLENELKE 899
S ++ +E++Q +LQ + ++K+L + + L+ + +K +LE+EL+E
Sbjct: 1033 SSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQE 1092
Query: 900 ALA---KIKELEMICQD---EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+ KIK LE + E +K + T + +
Sbjct: 1093 SRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQ----LKKMVEDLECEIGEMYVVMKN 1009
QA L+ K++ + K + L + + LK+ V + E G K
Sbjct: 1153 NLQVQAVLQR-KEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKA 1211
Query: 1010 AGLS----GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
A L KE+ AK L +++ L + + + E + Q E+A+ + L+
Sbjct: 1212 ASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQ 1271
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
D +K A E NL + E+++ + Q++
Sbjct: 1272 LDEQLSKQPAGNQEMENLKWEVDQKEREIQSLKQQLD 1308
Score = 62.9 bits (146), Expect = 1e-08
Identities = 124/612 (20%), Positives = 258/612 (42%), Gaps = 55/612 (8%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRP--STEAQTRQIEQLRAKLL 375
E ++L+ ++ L+ EK L ++ + ++L+ + S +Q RQ + L +++
Sbjct: 413 EKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQ-DSLSSEVD 471
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTI--KNC 431
+ C +L D++ L ++ + E+Q + ++++++ K+
Sbjct: 472 TLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDN 531
Query: 432 RVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKE-LEQEVARSTEVAL 490
V + + T ++ QL+Q + E ++ + +++ +Q++A + E +
Sbjct: 532 TVHDLRQQMTALQS-QLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARV 590
Query: 491 RLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS-SLTRGGSQEDPAQLLRDLQDSLERE 549
RLQ E+A + L++ + E V +S+ + T+ S ++ ++ LQ E
Sbjct: 591 RLQGEMAHIQVGQM-TQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI---E 646
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
AD+ +Q A Q+ + + M + + + E E +Q AAS
Sbjct: 647 ADMLDQ-------EAAFMQIQ-----EAKTMVEEDLQRRLEEFEGERERLQRMADSAASL 694
Query: 610 PSSKEKSDSPPLSIDKTTEETQF-HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
E+ L D+ E Q H DL A + ++ ++ + L +L
Sbjct: 695 EQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTRYDELQARL 754
Query: 669 KKMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEADPAEMKL---------LLELNE 718
++ +A SR+ + N K+ +E A + +E D +L LE
Sbjct: 755 GELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLR 814
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
+E + +VE L+Q+ ALKKQ++++ + K RR T+ ++E +
Sbjct: 815 EELAIKSGQVEHLQQETAALKKQMQKIKEQFLQ-QKVMV---EAYRRDATSKDQLISELK 870
Query: 779 V--KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ 836
K L+ E+ E+R++L++ + AELS R + Q DL+
Sbjct: 871 ATRKRLDSELKELRQELMQVHGEKRTAEAELSRLH---------REVAQVRQHMADLEGH 921
Query: 837 LQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL-KNAKSLRSD--KALDLNTKKTTQL 893
LQ ++E + QSL+ D E++ + + L K + L+ + KA+ +K +L
Sbjct: 922 LQSAQKERDEVETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRL 981
Query: 894 ENELKEALAKIK 905
++L A ++K
Sbjct: 982 GSDLTSAQKEMK 993
Score = 54.4 bits (125), Expect = 4e-06
Identities = 163/753 (21%), Positives = 295/753 (39%), Gaps = 86/753 (11%)
Query: 787 DEVRKKLIEKERDCERLHA--------ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
++++++L E E + ERL E L Q K L + + L+A Q+++DL +QL
Sbjct: 668 EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQL- 726
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
+ QEA L+++ QSL+A + +L L+ + R D L +K LE L+
Sbjct: 727 TLTQEA--LQSREQSLDALQTRYDELQARLGELQGEAASREDTICLLQNEKII-LEAALQ 783
Query: 899 EALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
A + +EL+ + R E T++ ++TL+ + Q
Sbjct: 784 AAKSGKEELDRGAR--------RLEEGTEETSETLEKLREELAIKSGQVEHL-------Q 828
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
+LK QK K + LQ K MVE + K+ +S + T
Sbjct: 829 QETAALKKQMQK-IKEQF----------LQQKVMVEAYRRD-----ATSKDQLISELKAT 872
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTN---EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKA 1075
K +L+ E+ E+R +L + E E +RL E+A+++ A LEG +
Sbjct: 873 RK-RLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDE 931
Query: 1076 LENENSNLS---NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXX 1132
+E +L Q +TE + + QI +L + + A + Q +
Sbjct: 932 VETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKE 991
Query: 1133 XXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLS 1192
+ ++ Q+ + + ++ +RI+ L
Sbjct: 992 MKTKHKAYENAVGI--LSRRLQEALAAREAADAELGQLRAQGGSSDSSLALHERIQA-LE 1048
Query: 1193 TRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSE-KDELQ-ARFIKTESKFITLEAE 1250
V+ + + L + S E E +DELQ +R + + K + +
Sbjct: 1049 AELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNK 1108
Query: 1251 MRDLKADYEN-KITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXX 1309
L+ ++E K+T L + AA H LE AL + D + V+ V R
Sbjct: 1109 KLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLV-QLNLQVQAVLQRK---- 1163
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA--KLENXXXXXXXXXXXXX 1367
++E K ++ +A K ++ LK +A K+E
Sbjct: 1164 --------EEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE 1215
Query: 1368 XXSSYWENKAKE-LDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQ----- 1421
E +AKE L LQ+E L H +++ AELA + +L++L++
Sbjct: 1216 LSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQ 1275
Query: 1422 --NSGAGAKRITELKQEY---EETVKKLEHSLAL-EKAEYEELTGKYELLEEEHVVTKAR 1475
AG + + LK E E ++ L+ L L E+ ++EL G +LL ++V ++
Sbjct: 1276 LSKQPAGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGWKELEGLQQLL--QNVKSELE 1333
Query: 1476 LTVEK-EQAQGELLHVQKELSTALGEIKTLQEK 1507
+ E Q + +Q ++S +KTL ++
Sbjct: 1334 MAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQ 1366
Score = 46.8 bits (106), Expect = 8e-04
Identities = 74/354 (20%), Positives = 136/354 (38%), Gaps = 33/354 (9%)
Query: 1426 GAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQG 1485
GA+R+ E +E ET++KL LA++ + E L + L+++ K + +K +
Sbjct: 795 GARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEA 854
Query: 1486 ELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL 1545
+ + E+K +++L +E E ++ + + L EV A++
Sbjct: 855 YRRDATSK-DQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREV--AQV 911
Query: 1546 NARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXX 1605
+ E L++A RD +E H D E++ +
Sbjct: 912 RQHMADLEGHLQSAQKERDEVETH----------LQSLQFDKEQMVAVTEANEALKKQIE 961
Query: 1606 XXXXXXXXXI-EQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQM 1664
I EQ +K R+ T + E M+ + K+ N V R
Sbjct: 962 ELQQEARKAITEQKQKMRRLGSDLTSAQKE-----MKTKHKAYENAVGILSRRLQEALAA 1016
Query: 1665 LEAAQKSMAEIK----NGDKSARIH-RNSISSTDEEEYRNKVALLEQQ----VACLEDEL 1715
EAA + +++ + D S +H R + + + LLE++ +A EL
Sbjct: 1017 REAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQEL 1076
Query: 1716 CESRLLASKLNTELVSEKSSAE--VRLAEMQSRLN---EYEEERLLSSGRARVA 1764
ESR +L EL + + RL E +L E+E+ +L G++ A
Sbjct: 1077 EESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAA 1130
Score = 45.2 bits (102), Expect = 0.002
Identities = 70/375 (18%), Positives = 143/375 (38%), Gaps = 18/375 (4%)
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ 1491
E Q ++ LE L K + + E L++EH+ +LT+ +E Q +
Sbjct: 682 ERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLD 741
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCG---GGWEVERA--RLN 1546
L T E++ +L E+A+ +QN L+ L G E++R RL
Sbjct: 742 A-LQTRYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLE 800
Query: 1547 ARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXX 1606
++ L + + + + Q+
Sbjct: 801 EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDAT 860
Query: 1607 XXXXXXXXIEQSEKARKAEITDTKT---RYEGQMNTMRDELKSLHNQVSRFRRERDNYKQ 1663
++ + K +E+ + + + G+ T EL LH +V++ R+ + +
Sbjct: 861 SKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEG 920
Query: 1664 MLEAAQKSMAEIKNGDKSARIHRNSISSTDE--EEYRNKVALLEQQV-ACLEDELCESRL 1720
L++AQK E++ +S + + + + E E + ++ L+Q+ + ++ + R
Sbjct: 921 HLQSAQKERDEVETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRR 980
Query: 1721 LASKLNT---ELVSEKSSAEVRLAEMQSRLNEYEEERLLSS---GRARVAGLATRMELAW 1774
L S L + E+ ++ + E + + RL E R + G+ R G ++ LA
Sbjct: 981 LGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAREAADAELGQLRAQGGSSDSSLAL 1040
Query: 1775 HKERDEQQRLLQETS 1789
H+ + LQ S
Sbjct: 1041 HERIQALEAELQAVS 1055
Score = 44.8 bits (101), Expect = 0.003
Identities = 60/282 (21%), Positives = 122/282 (43%), Gaps = 37/282 (13%)
Query: 1227 TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQT 1286
T +++LQ R + E + L+ M D A E ++ ++ T+ +D +QLE AL+Q
Sbjct: 664 TMVEEDLQRRLEEFEGERERLQ-RMADSAASLEQQLEQVKLTLLQRD---QQLE-ALQQE 718
Query: 1287 TNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLK 1346
D + T E ++ R + L+ + + ++ +A + E A +
Sbjct: 719 HLDLMKQLTLTQEALQSR-------------EQSLDALQTRYDELQARLGELQGEAASRE 765
Query: 1347 SDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKD 1406
+ L+N + A+ L+ + + L+++R
Sbjct: 766 DTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLR----------- 814
Query: 1407 AELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLE 1466
ELA G+++ L+Q + A K++ ++K+++ L+ + +E A + T K +L+
Sbjct: 815 EELAIKSGQVEHLQQETAALKKQMQKIKEQF------LQQKVMVE-AYRRDATSKDQLIS 867
Query: 1467 EEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
E T+ RL E ++ + EL+ V E TA E+ L ++
Sbjct: 868 ELK-ATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREV 908
Score = 40.3 bits (90), Expect = 0.069
Identities = 52/255 (20%), Positives = 104/255 (40%), Gaps = 26/255 (10%)
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
+E ++LE ES + ++ +L+ KL ++
Sbjct: 1077 EESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNS 1136
Query: 1379 ELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYE 1438
L+T L L ++ + ++ K+ E +K ++ L+ + +++ LK++
Sbjct: 1137 ILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVA 1196
Query: 1439 ETVKKLEHSLALEKAEYEELTG-KYELLEEEHVVTKAR-----LTVEKEQAQGELLHVQK 1492
+ H+ KA EL+ K EL +EH+V K + L + + + E+ Q
Sbjct: 1197 AAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQA 1256
Query: 1493 ELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
EL+ A +++ LQ++L + + EM+N WEV DQ+
Sbjct: 1257 ELAEARAQLQLLQKQLDEQLSKQPAGNQEMENL-----------KWEV---------DQK 1296
Query: 1553 ERELRAANDRRDVLE 1567
ERE+++ + D+ E
Sbjct: 1297 EREIQSLKQQLDLTE 1311
>BC078168-1|AAH78168.1| 887|Homo sapiens KIAA1212 protein protein.
Length = 887
Score = 69.7 bits (163), Expect = 1e-10
Identities = 139/648 (21%), Positives = 264/648 (40%), Gaps = 62/648 (9%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE----LETRPSTEAQTRQIEQLRA 372
+++ +L+Q++ E T D + E + + +++ ++ E L S +++ LR
Sbjct: 255 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALRE 314
Query: 373 KLLAAETLCEEL------MDENEDMKKELRDLXXXXXXMQDN--FREDQADEYSSLRREL 424
K + + L E+ + + E K + +L + + EDQ + + +L
Sbjct: 315 KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 374
Query: 425 EQTIKNCRVLSFKLK--KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEV 482
+ K L KL + ER D+ + E+ E LE+ + + ELEQ +
Sbjct: 375 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ-I 433
Query: 483 ARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDL 542
+R++E++ Q+ L ++ T S +++ K T S E A + +
Sbjct: 434 SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 493
Query: 543 QDSLEREADLREQLRNA----EEETANCKQVNPPTFLDKQVMTDNIVTC----------- 587
+ +R + E L N ++ NC+ ++ +K + I T
Sbjct: 494 EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 553
Query: 588 ---DIHESETVTNSIQNKMIHAASTPSSKEKSDSP-PLSIDKTTEE-TQFHFDLPYLSI- 641
+ H ++TV++ Q I A + EK + SI +T+ + ++ F+ +
Sbjct: 554 EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 613
Query: 642 FNHMA-----ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETAND 696
H A L +E++NE LLQ K K K+ N +E N
Sbjct: 614 LEHYKEKGERAEELENELHHLEKENE--LLQKKITNLKITCEKIEALEQENS-ELERENR 670
Query: 697 NDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTS 756
+K D + LE E+E + L + EL ++ E+LK ++ +++ K
Sbjct: 671 KLKKTLDSFK--NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM-AQLQLENKEL 727
Query: 757 AGSNTTARRSLTTNSNKLAE-ERVKV----LEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
++ L + ER++V L+ E ++K L + ++L +EL +
Sbjct: 728 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 787
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL 871
+ +TL K+ ++ + KR L+ +E+E L +T LE D ++L+ ENK+L+
Sbjct: 788 MENQTLQKNL-----EELKISSKR-LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 841
Query: 872 KNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK 919
K D L+ N K LE E K +I + C K KK
Sbjct: 842 AEIK----DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELKK 885
Score = 62.9 bits (146), Expect = 1e-08
Identities = 101/495 (20%), Positives = 216/495 (43%), Gaps = 43/495 (8%)
Query: 655 ARVEE--DNESLLLQLKKM------ATKARSRKLSPTPPAN-----KL-SIETANDNDEK 700
ARVEE ++ +LL+ K M T+ARS KL N KL +E D D K
Sbjct: 341 ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK 400
Query: 701 ETDEADPAEMKLLLELNEQ--EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ +E M L + + E+ L ++E++ + E + K L +++ +T +
Sbjct: 401 KIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLL 460
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
+SLT K EE ++ D ++ K+++ E++ +RL ++ + + + +
Sbjct: 461 KLEMENQSLT----KTVEE-LRTTVDSVEGNASKILKMEKENQRLSKKVEILENE--IVQ 513
Query: 819 KSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLKNA 874
+ +SL + DL ++ +E+ LR ++ LE +NE L N+ + L+
Sbjct: 514 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQR 570
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK 934
+ ++ + K+ L +KE +K+ ++E + + +K++ + + + L+
Sbjct: 571 SQISAEARVKDIEKENKILHESIKETSSKLSKIEF--EKRQIKKELEHYKEKGERAEELE 628
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLK-DDAQKSFKPRIPKKPTD----LTTKLQ- 988
++ +++L+ ++++ + R KK D LT +L+
Sbjct: 629 NELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES 688
Query: 989 LKK---MVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNE 1044
L+K +++ E+ +K A + ++ + K LE E ++++ L + F +
Sbjct: 689 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF-KK 747
Query: 1045 KNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
RL+ L N +L+ + K + LE+E +L + +TL + ++ + +L
Sbjct: 748 TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 807
Query: 1105 SADLKNATSLQTTMS 1119
K SL+ S
Sbjct: 808 EQLEKENKSLEQETS 822
Score = 42.3 bits (95), Expect = 0.017
Identities = 42/171 (24%), Positives = 84/171 (49%), Gaps = 17/171 (9%)
Query: 1374 ENKAKELDTDLQSERKKLDR-MRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITE 1432
EN +++ L+ E + L++ + + + +A + ++ + KIL ++ + ++++
Sbjct: 544 ENSERQIKI-LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 602
Query: 1433 LKQEYEETVKKLEHSLALEKAE-YEELTGKYELLEEEH-----VVTKARLTVEK----EQ 1482
++ E + K+LEH EK E EEL + LE+E+ +T ++T EK EQ
Sbjct: 603 IEFEKRQIKKELEH--YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 660
Query: 1483 AQGELLHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQNSIASLQ 1530
EL ++L L K L E L E++ + E E++ ++ SL+
Sbjct: 661 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK 711
Score = 37.1 bits (82), Expect = 0.64
Identities = 165/853 (19%), Positives = 316/853 (37%), Gaps = 72/853 (8%)
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL- 713
A + N S+L++ K + ++L N L I N E+ T+E + LL
Sbjct: 69 ASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGK-NPFSEQGTEEVKKLLLLLLG 127
Query: 714 LELNEQEATVLRRKVEELEQD-KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
+ Q+ +++ L+ D K A+ ++E+T +V T +
Sbjct: 128 CAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLL 187
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLH--AELSLAQKKPKTLIKSRSLDASDQQN 830
K +K L DE DE + +IE + + LH S + + P + ++ +
Sbjct: 188 KNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLS 247
Query: 831 VDLKRQLQVIEQEASVLRAKTQSL---EADNEKLQTENKKLQLLKNAKSLRSDKALDLNT 887
V+L I + L KT+ L + + E+++ E K+LQ + +L SD +
Sbjct: 248 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ--QENMNLLSDAR---SA 302
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
+ + L+E ++ +LE + + ++++ E K + LK
Sbjct: 303 RMYRDELDALREKAVRVDKLES--EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 360
Query: 948 XXXXXXXXXXQATLKSL-KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVV 1006
L L K++ Q K + D+ K + M E++ E+ + +
Sbjct: 361 EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 420
Query: 1007 MKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKN-RLQTEIAKLKDVNAKLEGD 1065
++ L G E+ ++ + + + L +E T+ + +L+ E L +L
Sbjct: 421 DESLHL-GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 479
Query: 1066 KD-VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXX 1124
D V N K L+ E N + L+++++ E +I + L+N Q D M
Sbjct: 480 VDSVEGNASKILKMEKEN-----QRLSKKVEILENEIVQEKQSLQNC---QNLSKDLMKE 531
Query: 1125 XXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXC 1184
+ KI + +N+ L + ++
Sbjct: 532 KAQLEKTIETLRENS-------ERQIKILEQENEHLNQTVSSLRQ-----RSQISAEARV 579
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKF 1244
K IEK+ +++ + + +E EK E +A ++ E
Sbjct: 580 KDIEKE-----NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHH 633
Query: 1245 ITLEAEMRDLKADYENKITSLEST---IAAKDVHIKQLEDALRQT--TNDKYDEATSPVE 1299
+ E E+ + KIT+L+ T I A + +LE R+ T D + T +E
Sbjct: 634 LEKENEL------LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 687
Query: 1300 MVEMRXXXXXXXXXXXXXQDE------LNNAKIKLEKTEAESSAAKLE--MAQLKSDLAK 1351
+E E + A+++LE E ES +L+ + LK+ K
Sbjct: 688 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKK 747
Query: 1352 LENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK---DVKNKDAE 1408
E EN K++ L+SE + L+ K ++K
Sbjct: 748 TERLEVSYQGLDIENQRLQKTLENSNKKIQ-QLESELQDLEMENQTLQKNLEELKISSKR 806
Query: 1409 LATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEE 1468
L L+ + K LEQ + ++ + K++ E+ K+L ++ EE K LE+E
Sbjct: 807 LEQLEKENKSLEQETS----QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 862
Query: 1469 HVVTKARLTVEKE 1481
+ + + KE
Sbjct: 863 NKTLSKEIGIYKE 875
>AL157400-6|CAI16830.1| 1820|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1820
Score = 69.3 bits (162), Expect = 1e-10
Identities = 162/870 (18%), Positives = 337/870 (38%), Gaps = 61/870 (7%)
Query: 280 VDILRKRCERVEKEKSDILLRRLANIDTA-NKYTTGRSSEVLKLQQKVNELTTHNEDLRD 338
++ L+K+ +KEK + + + +Y R ++ + + E+ N + R
Sbjct: 580 IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRL 639
Query: 339 EK-KHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRD 397
K L K E + +T+ +T + + E + + L D D+KK+
Sbjct: 640 AIFKDLVGKCDTREEAAKDICATKVETEETHNY----VGFEDIIDSLQDNVADIKKQAEI 695
Query: 398 LXXXXXXMQDNFREDQADE--YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEH 455
+ D E ++ ++ EL +T +LKK E ++D L QE
Sbjct: 696 AHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETS 755
Query: 456 EKKLL-------EIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
KK++ E++ D Q+E+ I E Q + E + + A+ +S N
Sbjct: 756 NKKIITQNQRIKELINIID--QKEDTINEF-QNLKSHMENTFKCN-DKADTSSLII--NN 809
Query: 509 SLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD----LQDSLEREADLREQLRNAEEETA 564
L+ E K S+S + + + +L +D + S+ + + E + +EE
Sbjct: 810 KLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRP 869
Query: 565 NCKQVNPPTFLDK--QVMTDNIVTCD--IHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
N ++ L + + + ++T + + + + +++H S EK +
Sbjct: 870 NIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKN--- 926
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANN-----LRKTAARVEEDNESL---LLQLKKMA 672
L++ K ++ Q ++D+ + + N + K + +E S+ + Q+K M
Sbjct: 927 LTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMH 986
Query: 673 TKARS-RKLSPTPPANKLSIETAND-NDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
TK R L + + + D ++ E D ++ LL V +++E
Sbjct: 987 TKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQE 1046
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
++ + ++ + + + K S+ + L KL E VK +DE + ++
Sbjct: 1047 PNREN-SFHSSIEAIWEECKEIVKASSKKSHQIEE-LEQQIEKLQAE-VKGYKDENNRLK 1103
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
+K + + D + E + Q K + K+ +LD Q V+ KR L + Q + +AK
Sbjct: 1104 EKEHKNQDDLLK-EKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAK 1162
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
+ LE E + E L+ + L L + + + L++++ K+L +
Sbjct: 1163 IKELETILETQKVECSHSAKLEQDILEKESIILKLE-RNLKEFQEHLQDSVKNTKDLN-V 1220
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ + E+ + T + L+ K+ A ++LK D Q
Sbjct: 1221 KELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQ- 1279
Query: 971 SFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEM-TAKTKLEKEID 1028
R + DL KL KK ++ ++ E+ M K + E+ K + +E+D
Sbjct: 1280 ----RKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD 1335
Query: 1029 EIRSKLSKNDSEFTNEK--NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+ + + + N+K +Q KD+N K + + + LE + Q
Sbjct: 1336 MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVK----EKIIEDMRMTLEEQEQTQVEQ 1391
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+ L +++ E +L + L+T
Sbjct: 1392 DQVLEAKLEEVERLATELEKWKEKCNDLET 1421
Score = 58.8 bits (136), Expect = 2e-07
Identities = 181/995 (18%), Positives = 398/995 (40%), Gaps = 86/995 (8%)
Query: 159 ITKNDSLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDD 218
I+ +SL + + L++ + E+ ++E + L K+ E+ K +E+ D
Sbjct: 520 ISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDL 579
Query: 219 VNFLMQ--VKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGL 276
+ L + + + L+ +R L+ ++ L
Sbjct: 580 IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRL 639
Query: 277 KQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE-- 334
D++ K C+ E+ DI ++ +T N G + LQ V ++ E
Sbjct: 640 AIFKDLVGK-CDTREEAAKDICATKVETEETHNY--VGFEDIIDSLQDNVADIKKQAEIA 696
Query: 335 --------DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
D ++ L K +I++EL +T+ E+L+ + +++L +EL
Sbjct: 697 HLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTK--EELKKRENESDSLIQELET 754
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK-NCRVLSFKLKKTERKA 445
N+ + + + + + +ED +E+ +L+ +E T K N + + L +
Sbjct: 755 SNKKIITQNQRIKELINIIDQ--KEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKL- 811
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
+ E E K + EN EL+Q+ + + ++ + + E K
Sbjct: 812 --ICNETVEVPKDSKSKICSERKRVNEN---ELQQDEPPAKKGSIHVSSAITEDQKKSEE 866
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
P++ ++ E ++V + + G + + +L++ E +A+L +Q+ + ++E +
Sbjct: 867 VRPNIAEI---EDIRVLQEN--NEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSL 921
Query: 566 CKQVNPPTFLDKQVMTDN--IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
++ N + Q + N I ++H ++ + K++ ++ + +S + +S
Sbjct: 922 SEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQ 981
Query: 624 DKTTEETQFHF-DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
K L +S +++ NLR + EEDN L ++ +S
Sbjct: 982 IKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDN----LPNTQLDLLGNDYLVSK 1037
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
++ E +N + EA E K +++ + +++ ++EELEQ E L+ +V
Sbjct: 1038 QVKEYRIQ-EPNRENSFHSSIEAIWEECKEIVKASSKKS----HQIEELEQQIEKLQAEV 1092
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCER 802
K + + + + + + T +L EE ++ +D + ++E +R
Sbjct: 1093 KGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEE-LQEKNVTLDVQIQHVVEGKRALSE 1151
Query: 803 LHAELSLAQKKPK---TLIKSRSLDASDQQNVD------------LKRQLQVIEQEASVL 847
L ++ + K K T+++++ ++ S ++ L+R L+ ++
Sbjct: 1152 LTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDS 1211
Query: 848 RAKTQSLEADNEKLQTE----NKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
T+ L KL+ E LQ +K+ L+ ++ + N ++T +L+ EL + A+
Sbjct: 1212 VKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEE-ETNRQETEKLKEELSASSAR 1270
Query: 904 IKELEMICQ---DEKSEKKVRFTEATK------KETDTLKSKQXXXXXXXXXXXXX---- 950
+ L+ Q ++ ++ K + T+A K KE ++ +
Sbjct: 1271 TQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQC 1330
Query: 951 XXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK-KMVEDLEC--EIGEMYVVM 1007
Q T++ LK+ ++ L +K K++ED+ E E V
Sbjct: 1331 SQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVE 1390
Query: 1008 KNAGLSGKEMTAK---TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL-E 1063
++ L K + T+LEK ++ +KN+ E + KL ++ +L E
Sbjct: 1391 QDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQE 1450
Query: 1064 GDKDVFANKYKALENENSNLSNQCKTLTEEMKNRE 1098
++ A++ K LE E L Q K E ++N+E
Sbjct: 1451 SEQKYNADRKKWLE-EKMMLITQAKE-AENIRNKE 1483
Score = 54.0 bits (124), Expect = 5e-06
Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 23/302 (7%)
Query: 1384 LQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE-QNSGAGAKRITELKQEYEET-- 1440
L+ ER + D KD + LK K +I + N+ K + +LK+E EET
Sbjct: 1195 LKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNR 1254
Query: 1441 --VKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
+KL+ L+ A + L + EE++ K +LT K+Q + VQKE+S
Sbjct: 1255 QETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQ----IKQVQKEVSVMR 1310
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEM---QNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
E K L+ K+ N E+ Q +I L+E+L +VE A + Q ER
Sbjct: 1311 DEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL--NNQKVEEA-----IQQYERA 1363
Query: 1556 LRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXI 1615
+ N + ++E + ++V + + +
Sbjct: 1364 CKDLNVKEKIIE----DMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1419
Query: 1616 EQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI 1675
E R + + T G++ ++DEL+ + + R++ K ML K I
Sbjct: 1420 ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENI 1479
Query: 1676 KN 1677
+N
Sbjct: 1480 RN 1481
>AL157389-2|CAI12886.1| 1820|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1820
Score = 69.3 bits (162), Expect = 1e-10
Identities = 162/870 (18%), Positives = 337/870 (38%), Gaps = 61/870 (7%)
Query: 280 VDILRKRCERVEKEKSDILLRRLANIDTA-NKYTTGRSSEVLKLQQKVNELTTHNEDLRD 338
++ L+K+ +KEK + + + +Y R ++ + + E+ N + R
Sbjct: 580 IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRL 639
Query: 339 EK-KHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRD 397
K L K E + +T+ +T + + E + + L D D+KK+
Sbjct: 640 AIFKDLVGKCDTREEAAKDICATKVETEETHNY----VGFEDIIDSLQDNVADIKKQAEI 695
Query: 398 LXXXXXXMQDNFREDQADE--YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEH 455
+ D E ++ ++ EL +T +LKK E ++D L QE
Sbjct: 696 AHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETS 755
Query: 456 EKKLL-------EIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
KK++ E++ D Q+E+ I E Q + E + + A+ +S N
Sbjct: 756 NKKIITQNQRIKELINIID--QKEDTINEF-QNLKSHMENTFKCN-DKADTSSLII--NN 809
Query: 509 SLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD----LQDSLEREADLREQLRNAEEETA 564
L+ E K S+S + + + +L +D + S+ + + E + +EE
Sbjct: 810 KLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRP 869
Query: 565 NCKQVNPPTFLDK--QVMTDNIVTCD--IHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
N ++ L + + + ++T + + + + +++H S EK +
Sbjct: 870 NIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKN--- 926
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANN-----LRKTAARVEEDNESL---LLQLKKMA 672
L++ K ++ Q ++D+ + + N + K + +E S+ + Q+K M
Sbjct: 927 LTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMH 986
Query: 673 TKARS-RKLSPTPPANKLSIETAND-NDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
TK R L + + + D ++ E D ++ LL V +++E
Sbjct: 987 TKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQE 1046
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
++ + ++ + + + K S+ + L KL E VK +DE + ++
Sbjct: 1047 PNREN-SFHSSIEAIWEECKEIVKASSKKSHQIEE-LEQQIEKLQAE-VKGYKDENNRLK 1103
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
+K + + D + E + Q K + K+ +LD Q V+ KR L + Q + +AK
Sbjct: 1104 EKEHKNQDDLLK-EKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAK 1162
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
+ LE E + E L+ + L L + + + L++++ K+L +
Sbjct: 1163 IKELETILETQKVECSHSAKLEQDILEKESIILKLE-RNLKEFQEHLQDSVKNTKDLN-V 1220
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ + E+ + T + L+ K+ A ++LK D Q
Sbjct: 1221 KELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQ- 1279
Query: 971 SFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEM-TAKTKLEKEID 1028
R + DL KL KK ++ ++ E+ M K + E+ K + +E+D
Sbjct: 1280 ----RKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD 1335
Query: 1029 EIRSKLSKNDSEFTNEK--NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+ + + + N+K +Q KD+N K + + + LE + Q
Sbjct: 1336 MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVK----EKIIEDMRMTLEEQEQTQVEQ 1391
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+ L +++ E +L + L+T
Sbjct: 1392 DQVLEAKLEEVERLATELEKWKEKCNDLET 1421
Score = 58.8 bits (136), Expect = 2e-07
Identities = 181/995 (18%), Positives = 398/995 (40%), Gaps = 86/995 (8%)
Query: 159 ITKNDSLAERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDD 218
I+ +SL + + L++ + E+ ++E + L K+ E+ K +E+ D
Sbjct: 520 ISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDL 579
Query: 219 VNFLMQ--VKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGL 276
+ L + + + L+ +R L+ ++ L
Sbjct: 580 IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRL 639
Query: 277 KQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE-- 334
D++ K C+ E+ DI ++ +T N G + LQ V ++ E
Sbjct: 640 AIFKDLVGK-CDTREEAAKDICATKVETEETHNY--VGFEDIIDSLQDNVADIKKQAEIA 696
Query: 335 --------DLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
D ++ L K +I++EL +T+ E+L+ + +++L +EL
Sbjct: 697 HLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTK--EELKKRENESDSLIQELET 754
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK-NCRVLSFKLKKTERKA 445
N+ + + + + + +ED +E+ +L+ +E T K N + + L +
Sbjct: 755 SNKKIITQNQRIKELINIIDQ--KEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKL- 811
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
+ E E K + EN EL+Q+ + + ++ + + E K
Sbjct: 812 --ICNETVEVPKDSKSKICSERKRVNEN---ELQQDEPPAKKGSIHVSSAITEDQKKSEE 866
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
P++ ++ E ++V + + G + + +L++ E +A+L +Q+ + ++E +
Sbjct: 867 VRPNIAEI---EDIRVLQEN--NEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSL 921
Query: 566 CKQVNPPTFLDKQVMTDN--IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
++ N + Q + N I ++H ++ + K++ ++ + +S + +S
Sbjct: 922 SEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQ 981
Query: 624 DKTTEETQFHF-DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
K L +S +++ NLR + EEDN L ++ +S
Sbjct: 982 IKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDN----LPNTQLDLLGNDYLVSK 1037
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
++ E +N + EA E K +++ + +++ ++EELEQ E L+ +V
Sbjct: 1038 QVKEYRIQ-EPNRENSFHSSIEAIWEECKEIVKASSKKS----HQIEELEQQIEKLQAEV 1092
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCER 802
K + + + + + + T +L EE ++ +D + ++E +R
Sbjct: 1093 KGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEE-LQEKNVTLDVQIQHVVEGKRALSE 1151
Query: 803 LHAELSLAQKKPK---TLIKSRSLDASDQQNVD------------LKRQLQVIEQEASVL 847
L ++ + K K T+++++ ++ S ++ L+R L+ ++
Sbjct: 1152 LTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDS 1211
Query: 848 RAKTQSLEADNEKLQTE----NKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
T+ L KL+ E LQ +K+ L+ ++ + N ++T +L+ EL + A+
Sbjct: 1212 VKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEE-ETNRQETEKLKEELSASSAR 1270
Query: 904 IKELEMICQ---DEKSEKKVRFTEATK------KETDTLKSKQXXXXXXXXXXXXX---- 950
+ L+ Q ++ ++ K + T+A K KE ++ +
Sbjct: 1271 TQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQC 1330
Query: 951 XXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK-KMVEDLEC--EIGEMYVVM 1007
Q T++ LK+ ++ L +K K++ED+ E E V
Sbjct: 1331 SQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVE 1390
Query: 1008 KNAGLSGKEMTAK---TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL-E 1063
++ L K + T+LEK ++ +KN+ E + KL ++ +L E
Sbjct: 1391 QDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQE 1450
Query: 1064 GDKDVFANKYKALENENSNLSNQCKTLTEEMKNRE 1098
++ A++ K LE E L Q K E ++N+E
Sbjct: 1451 SEQKYNADRKKWLE-EKMMLITQAKE-AENIRNKE 1483
Score = 54.0 bits (124), Expect = 5e-06
Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 23/302 (7%)
Query: 1384 LQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE-QNSGAGAKRITELKQEYEET-- 1440
L+ ER + D KD + LK K +I + N+ K + +LK+E EET
Sbjct: 1195 LKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNR 1254
Query: 1441 --VKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
+KL+ L+ A + L + EE++ K +LT K+Q + VQKE+S
Sbjct: 1255 QETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQ----IKQVQKEVSVMR 1310
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEM---QNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
E K L+ K+ N E+ Q +I L+E+L +VE A + Q ER
Sbjct: 1311 DEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL--NNQKVEEA-----IQQYERA 1363
Query: 1556 LRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXI 1615
+ N + ++E + ++V + + +
Sbjct: 1364 CKDLNVKEKIIE----DMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1419
Query: 1616 EQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI 1675
E R + + T G++ ++DEL+ + + R++ K ML K I
Sbjct: 1420 ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENI 1479
Query: 1676 KN 1677
+N
Sbjct: 1480 RN 1481
>AB058696-1|BAB47422.1| 1270|Homo sapiens KIAA1793 protein protein.
Length = 1270
Score = 69.3 bits (162), Expect = 1e-10
Identities = 149/714 (20%), Positives = 291/714 (40%), Gaps = 66/714 (9%)
Query: 273 IEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYT--TGRSSEVLKLQQKVNELT 330
+ L +E + + E VE+E+ + + NK+ + +E+ +L+ +V +L
Sbjct: 126 LPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLV 185
Query: 331 THNEDLRDEKKHLTQKIREIESELETRPSTEAQ-----TRQIEQLRAKLLAAETLCEELM 385
E+ R+ E++ LE AQ T+QI+QL+ +L + L
Sbjct: 186 AELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLE 245
Query: 386 DENEDMKKEL-RDLXXXXXXMQD--NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTE 442
E E KE+ ++L +Q ED A E+ S L++ + CR+ + +L+ E
Sbjct: 246 HEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDL--CRMQN-ELEDME 302
Query: 443 RKADQLEQE----KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
R E E +AE E K E G G+ + ++E QE+ R L E
Sbjct: 303 RIRGDYEMEIASLRAEMEMKSSE-PSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQE 361
Query: 499 ANSKFTGSNPSL-MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
+NS TG L + Q T + +S S E + L+ E + LR+QLR
Sbjct: 362 SNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQL-LRQQLR 420
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES--ETVTNSIQNKMIHAASTPS--SK 613
+AEE+ K + + + + + + + QN+++ ++ S
Sbjct: 421 DAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQN 480
Query: 614 EKSDSPPLSIDK---TTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
E+ S ++ K T+++ Q L + + + K+ + + LL +L+K
Sbjct: 481 EELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQK 540
Query: 671 MATK------------ARSRKLSPTPPANKLSIETAND-------NDEKETD-EADPAEM 710
+ + R ++L ++ ++ D ++EK+T+ A EM
Sbjct: 541 LHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEM 600
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
K L + ++ E + ++LEQD + ++KEL K S G +L +
Sbjct: 601 KQLYQASKDELERQKHMYDQLEQDLLLCQLELKEL--KASHPIPEDKGKCANKCDTLLSR 658
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAE----------LSLAQKKPKTLIKS 820
+L +E+ K + E+ +++ + E D R+ E L+L K L+KS
Sbjct: 659 LTEL-QEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKS 717
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL------QLLKNA 874
+ L + +L+ Q +++E L + + ++ E ++ ++L+N
Sbjct: 718 QELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENP 777
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKK 928
+ K+ N K ++L E +AL + + Q+ +++ R E K+
Sbjct: 778 DDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKR 831
Score = 59.7 bits (138), Expect = 1e-07
Identities = 128/620 (20%), Positives = 242/620 (39%), Gaps = 29/620 (4%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDT----ANKYTTGRSSEVLK 321
+++ Q ++ L++E+ +L E KE L A I + A T S++
Sbjct: 227 IQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIAS 286
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETR---PSTEAQTRQIEQLRAKLLAAE 378
LQ+ + + ED+ + +I + +E+E + PS L+ +L
Sbjct: 287 LQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELR 346
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
L +E +++ L ++ R +A E + L T +
Sbjct: 347 ERYHFLNEEYRALQESNSSLTGQLADLESE-RTQRATERWLQSQTLSMTSAESQTSEMDF 405
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ + + L Q+ + E+++ + + E ++EL+ S E RLQREL
Sbjct: 406 LEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCE--LEELQHHRQVSEEEQRRLQRELKC 463
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTR--GGSQEDPAQLLRDLQDSLEREADLREQL 556
A ++ S V Q E +K +L + SQ++ +LL+ +Q L+ E + +
Sbjct: 464 AQNEVLRFQTS-HSVTQNEELKSRLCTLQKKYDTSQDEQNELLK-MQLQLQTELRQLKVM 521
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM-IHAASTPSSKEK 615
++ E + K++ L K + VTC+ + +Q ++ H A ++
Sbjct: 522 KSTLVENQSEKELL--CRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDT 579
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL-QLKKMATK 674
S S +K TE H L + + + L + ++ + LLL QL+ K
Sbjct: 580 VASFKESNEKDTET---HAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELK 636
Query: 675 ARSRKLSPTPP--ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE 732
A S + ANK + + +E +A EM L + RR EE
Sbjct: 637 A-SHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQG 695
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
Q +E L + L + + L + EE+ K+++++ D V K+
Sbjct: 696 QLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQ-DCVLKE 754
Query: 793 LIEKERDCERL---HAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
+E + R H + L L KS + + Q + L Q+Q ++ +A
Sbjct: 755 QLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKL-LMEQMQALQVMYDAGQA 813
Query: 850 KTQSLEADNEKLQTENKKLQ 869
K + L+ + +L E K+LQ
Sbjct: 814 KQELLQQEQGRLLEERKRLQ 833
Score = 45.2 bits (102), Expect = 0.002
Identities = 125/592 (21%), Positives = 244/592 (41%), Gaps = 54/592 (9%)
Query: 294 KSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESE 353
K D LL RL + KY + E+ +LQ + EL +++E+ L +++ +
Sbjct: 651 KCDTLLSRLTELQ--EKYKASQK-EMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLP 707
Query: 354 LETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ 413
L P + + ++L KL E LCE L + M++E + L QD ++Q
Sbjct: 708 L---PKSGLLLKS-QELLTKL---EDLCE-LQLLYQGMQEEQKKLIQN----QDCVLKEQ 755
Query: 414 ADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQREN 473
+ + LRR E + VL K+ + + K K L+E + M
Sbjct: 756 LEIHEELRRFKESHFQE--VLENPDDSKLAKSSKCNRNK--QSKLLMEQMQALQVMYDAG 811
Query: 474 RIKE--LEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS 531
+ K+ L+QE R E RLQ +L + L++V P ++K+S S +
Sbjct: 812 QAKQELLQQEQGRLLEERKRLQADLQLCLEEM-----QLLQVQSP-SIKMSLESYGKSYG 865
Query: 532 QEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHE 591
P+ + + + + D E + T Q + +FL + +
Sbjct: 866 SMVPSN--ENCRKTYDTTVDDNESYYKSYTST----QTSSKSFLKSYDSSTSASEAYGKS 919
Query: 592 SETVTNS--IQNKMIHAASTPSSKEKSDSPPLSIDKTTE-ETQFHFDLPYLSIFNHMAAN 648
T +NS K + S+ + +KS + ++ E E F+ + + + A
Sbjct: 920 YCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAV 979
Query: 649 NL-----RKTAARVEEDNESLLLQLKKMATK--ARSRKLSPTPPANKLSIETANDNDEKE 701
++ ++++E E LL + K + + A R+ + + ND +E +
Sbjct: 980 QAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIK 1039
Query: 702 TDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+ E++L + + E L E+LE + ++++++L K SV K + G N
Sbjct: 1040 ELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKN- 1098
Query: 762 TARRSLTTNSNKLAEERV-KVLED--EIDEVRKKLIEKERDCERLHAEL-SLAQKKPKTL 817
A +++ N+N + ++V K D E D +K +E + +L LA+++ K
Sbjct: 1099 -ANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEK-- 1155
Query: 818 IKSRSLDASDQQNVDLKRQL--QVIEQEASVLRAKTQSLEADNEKLQTENKK 867
K + + + K Q +++ + A AK+ + +NE+ + E +K
Sbjct: 1156 -KEEMEEEKKEVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEK 1206
Score = 44.4 bits (100), Expect = 0.004
Identities = 116/542 (21%), Positives = 219/542 (40%), Gaps = 56/542 (10%)
Query: 413 QADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRE 472
+ + SL R Q ++ VL L + E + ++ E+E E E+++ + GG G
Sbjct: 105 KGQRWGSLERRGMQAMEG-EVLLPALYEEEEEEEEEEEEVEEEEEQVQK--GGSVGSLSV 161
Query: 473 NRIKEL---EQEVARSTEVALRLQRELAEANS---KFTGSNPSLMKVPQPETVKVSRSSL 526
N+ + L E E+ L+L EL E + + L + + E + ++ +
Sbjct: 162 NKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAE 221
Query: 527 TRGGSQEDPAQLLRDLQDSL-----EREADLRE---QLRNAEEETANCKQV--NPPTFLD 576
+ LR L++ + E+E++L+E +L A+ E + +Q + T +
Sbjct: 222 VFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHE 281
Query: 577 KQVMTDNIVTCDI-HESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFD 635
+ + C + +E E + + + AS + E S P ++ + +
Sbjct: 282 SDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEE 341
Query: 636 LPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETA- 694
L L H R ++E N SL QL + ++ R + LS+ +A
Sbjct: 342 LQELRERYHFLNEEYRA----LQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAE 397
Query: 695 NDNDEKETDEADPAEMKLL---LELNEQEATVLRRKVEELEQDKEALK--KQV------- 742
+ E + E DP EM+LL L E++ ++ K +EL + E L+ +QV
Sbjct: 398 SQTSEMDFLEPDP-EMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRR 456
Query: 743 --KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDC 800
+EL + V + + T L + L +++ +DE +E+ K ++ + +
Sbjct: 457 LQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTL-QKKYDTSQDEQNELLKMQLQLQTEL 515
Query: 801 ERLHAELSLA---QKKPKTLIKSRSLDASDQ-----------QNVDLKRQLQVIEQEASV 846
+L S Q + + L + + L Q + L+ +LQ E E
Sbjct: 516 RQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQH 575
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
LR S + NEK + +LQ +K D+ L+ QLE +L ++KE
Sbjct: 576 LRDTVASFKESNEKDTETHAQLQEMKQLYQASKDE-LERQKHMYDQLEQDLLLCQLELKE 634
Query: 907 LE 908
L+
Sbjct: 635 LK 636
Score = 43.2 bits (97), Expect = 0.010
Identities = 72/346 (20%), Positives = 138/346 (39%), Gaps = 50/346 (14%)
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKAR---LTVEKEQAQGE 1486
+ EL+ + + V +LE + L ++ LLE+E + + + T + +Q QGE
Sbjct: 174 LEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGE 233
Query: 1487 LLHVQKELSTAL----GEIKTLQEKLGTESA-------AWNTEKTEMQNSIASLQERLC- 1534
L +++E+S E+K ++++L A A TE ++ IASLQE LC
Sbjct: 234 LRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCR 293
Query: 1535 -----------GGGWEVERARLNARLDQR----------------ERELRAANDRRDVLE 1567
G +E+E A L A ++ + + EL+ +R L
Sbjct: 294 MQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLN 353
Query: 1568 HHHDXXXXXXXXXXXXXXDY--ERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAE 1625
+ D ER + ++ E + +
Sbjct: 354 EEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQ 413
Query: 1626 ITDTKTR-YEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSM-AEIKNGDKSAR 1683
+ + R E QM+ M+++ + L ++ E +++Q+ E Q+ + E+K
Sbjct: 414 LLRQQLRDAEEQMHGMKNKCQELCCEL----EELQHHRQVSEEEQRRLQRELKCAQNEVL 469
Query: 1684 IHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
+ S S T EE ++++ L+++ +DE E + +L TEL
Sbjct: 470 RFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTEL 515
Score = 41.9 bits (94), Expect = 0.022
Identities = 51/244 (20%), Positives = 101/244 (41%), Gaps = 12/244 (4%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
+LQ+++ +L +DL++E ++ +E LE + + +I++L+ KL +
Sbjct: 992 QLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQ 1051
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQD---NFREDQADEYSSLRRELEQTIKNCRVLSFK 437
+ MDE + L Q+ RE + R + N K
Sbjct: 1052 YQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVK 1111
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+KK + + E +K LE+V QR ++ L +E + E+ ++E+
Sbjct: 1112 MKKVTKPCSDTSESDLE-TRKSLEVVLYYKASQR--KLDGLAKEEEKKEEME-EEKKEVK 1167
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
E + G V +P + ++S+ + ++ED + ++ +DS E E D L
Sbjct: 1168 EEAKEQCGDE----LVAEPADPEEAKSTEDQEENEEDKEEEEKE-EDSEEEEDDADSSLE 1222
Query: 558 NAEE 561
+ EE
Sbjct: 1223 SPEE 1226
>BX641024-1|CAE46015.1| 1694|Homo sapiens hypothetical protein
protein.
Length = 1694
Score = 68.9 bits (161), Expect = 2e-10
Identities = 266/1435 (18%), Positives = 541/1435 (37%), Gaps = 119/1435 (8%)
Query: 154 QTQLAITKNDSLAERVR-KMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDER 212
Q QL + K + E K++ K Q S K+ E+ER L++S E+ R +
Sbjct: 80 QEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKER-ILAQSASVEEVFRLQQAL 138
Query: 213 SSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQ 272
S ++++ L + +L + + N++ + +
Sbjct: 139 SDAENEIMRLSSLNQEELQMSLLK-LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQE 197
Query: 273 IEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTH 332
+ E + L E ++++ + + D +K S + KL+Q +N+
Sbjct: 198 LNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKR 257
Query: 333 NEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMK 392
L D+K +T +E++ + E +E + + KL E E L+D+ +
Sbjct: 258 VHQLEDDKMDIT---KELDVQKEKLIQSEVALNDLHLTKQKL---EDKVENLVDQLNKSQ 311
Query: 393 KELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK---LKKTERKADQLE 449
+ + ++++ R+++ +E S +R EL Q++ +FK LK+ E + L+
Sbjct: 312 ESNVSIQKENLELKEHIRQNE-EELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLK 370
Query: 450 QE--KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSN 507
Q + E + L+ V M+ E + E +V E L +L+ + +
Sbjct: 371 QNLSELEQLNENLKKVAFDVKMENEKLVLACE-DVRHQLEECLAGNNQLSLEKNTIVETL 429
Query: 508 PSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL---RDLQDS-LEREADLREQLRNAEE-E 562
+ E + L E + L R+L S L+ E + +L ++ E
Sbjct: 430 KMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDME 489
Query: 563 TANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS 622
A K+ D + T ++++ + E + +T I K I KE+S
Sbjct: 490 IAELKKNIEQMDTDHKE-TKDVLSSSLEEQKQLTQLINKKEIFIEKL---KERSSKLQEE 545
Query: 623 IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL-S 681
+DK ++ + + L + ++++ ++E+ E L + + A A + L S
Sbjct: 546 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDS 605
Query: 682 PTPPANKLS-IETANDNDEKET-------DEADPAEMKLLLELNEQ--EATVLRRKVEE- 730
T A+++S + T ++ E+E ++ + ++M+LL L EQ E R + E+
Sbjct: 606 VTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQM 665
Query: 731 --------LEQDKE--ALKKQVKELTSKISSVTKTSAGSNT-----TARRSLTTNS---- 771
LE+D+E +L+K ++++ +++ + N+ T +SL +
Sbjct: 666 NATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEK 725
Query: 772 ---NKLAEER----VKVLEDEIDEVRKKLIEKERDCERLHAE-----LSLAQKKPKTL-- 817
+K ER +K E EI + +K I + ++L + + Q+K +
Sbjct: 726 HDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQA 785
Query: 818 IKSRSLDASDQQNVD-LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
+ +R S Q+V L++QLQ E + A +N L+TE K+ + AK
Sbjct: 786 LHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKE 845
Query: 877 LRSDKALDLNTKKTTQLENELKEALAK-IKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
K D N K +T+ E+ ++ + I+ L I +++ E +A ++ TL +
Sbjct: 846 AALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIE-----IDALSQKCQTLLA 900
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK--SFKPRIPKKPTDLT-TKLQLKKM 992
+LK +K +K ++ ++ QL++
Sbjct: 901 VLQTSSTGNEAGGVNSNQFEELLQERDTLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 960
Query: 993 VEDLECEI-----GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+ L+ ++ + + GL +TKL K + +++ + + N K+
Sbjct: 961 LHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKL-KNFGQELAQVQHSIGQLCNTKDL 1019
Query: 1048 LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN-LSNQCKTLTEEMKNREAQINKLSA 1106
L + KL ++ +L + + L S LS + L +E++ + + A
Sbjct: 1020 L---LGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDA 1076
Query: 1107 DLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQ-VDNYTKIDQDKNKLLKEVGD 1165
++ +SD + + D K+ ++K+ L+K D
Sbjct: 1077 TIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSD 1136
Query: 1166 K--------TKKIGDXXXXXXXXXXXCKRI---EKQLSTRKDRVTXXXXXXXXXXXQAVV 1214
+ T K+ + +RI E + K +
Sbjct: 1137 QLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQA 1196
Query: 1215 LANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDV 1274
L T+ + S+ L ++ E + K + F L E K N++ + ++ K V
Sbjct: 1197 LQETNMKFSMMLREKEFECHSMKEKALA-FEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1255
Query: 1275 HIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKT-EA 1333
+Q D + K E T+ +V+ + L N ++ E +
Sbjct: 1256 VFQQERDQVMLALKQKQMENTALQNVVQ---RLRDKEFRSNQELERLRNHLLESEDSYTR 1312
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
E+ AA+ A+L+ + LE +S +E + +R +
Sbjct: 1313 EALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETAL 1372
Query: 1394 MRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKA 1453
+ VK LA L+ L+ +Q E K Y ++K + +A K
Sbjct: 1373 QLSVSQEQVKQYALSLANLQMVLEHFQQ----------EEKAMYSAELEKQKQLIAEWKK 1422
Query: 1454 EYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
E L GK L+E + +A ++ E L V++E L L++++
Sbjct: 1423 NAENLEGKVISLQE--CLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEM 1475
Score = 55.6 bits (128), Expect = 2e-06
Identities = 264/1531 (17%), Positives = 563/1531 (36%), Gaps = 109/1531 (7%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLA 376
S++ ++Q+ + L + + + L KI++I +L S+ R I + + L
Sbjct: 29 SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKL----SSAENDRDILRREQEQLN 84
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE----LEQTIKNCR 432
E ++M+E E++K E L D E + S E L+Q + +
Sbjct: 85 VEK--RQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAE 142
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPD----------GMQRENRIKELEQEV 482
+L ++ Q+ K +E ++++ D + E + +EL Q +
Sbjct: 143 NEIMRLSSLNQEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSI 202
Query: 483 A-RSTEVAL--RLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL 539
+ + T +A L R+ EA L K +S+ ++ QL
Sbjct: 203 SEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLE 262
Query: 540 RDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSI 599
D D + +E D++++ E N + DK +N+V +++S+ SI
Sbjct: 263 DDKMD-ITKELDVQKEKLIQSEVALNDLHLTKQKLEDK---VENLVD-QLNKSQESNVSI 317
Query: 600 QNKMIHAASTPSSKEKSDSPPLS--IDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARV 657
Q + + E+ S + + +++ +F L NL++ + +
Sbjct: 318 QKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKE-REAEVRNLKQNLSEL 376
Query: 658 EEDNESLLLQLKKMA--TKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLE 715
E+ NE+L KK+A K + KL + +E + + + E + L +E
Sbjct: 377 EQLNENL----KKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKME 432
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
E EA + K LE+ + +K ++EL++ + T + + ++A
Sbjct: 433 KGEIEAELCWAKKRLLEEANK-YEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIA 491
Query: 776 E-----ERVKVLEDEIDEVRKKLIEKERDCERL--HAELSLAQKKPKTLIKSRSLDASDQ 828
E E++ E +V +E+++ +L E+ + + K ++ LD Q
Sbjct: 492 ELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQ 551
Query: 829 ---QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL 885
+N L++ ++ ++ ++ + L+ + E+L+ E + + + K+L S L
Sbjct: 552 ALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELAS 611
Query: 886 NTKKTTQLENELKEALAKIKELEMICQDEKSEKK--VRFTEATKKETDTLKSK-QXXXXX 942
+ ++ L+E +IK + I +D+ K ++ + KKE D + + +
Sbjct: 612 EVSQLNTIKEHLEE---EIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNAT 668
Query: 943 XXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDL--TTKLQLKKMVEDLEC-E 999
Q T++ +K + + I +D+ TK+Q + E +
Sbjct: 669 HTQLFLEKDEEIKSLQKTIEQIKTQLHEE-RQDIQTDNSDIFQETKVQSLNIENGSEKHD 727
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRS--KLSKND-SEFTNEKNRLQTEIAKLK 1056
+ + G+ +E+ K EK I + +LSK++ + T + EI L
Sbjct: 728 LSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALH 787
Query: 1057 DVNAKLEGDKDV--FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSL 1114
+ +DV + +A E + T E + + + +K+ + +
Sbjct: 788 ARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAA 847
Query: 1115 QTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI---- 1170
+ D + N ++I ++K+ + + K + +
Sbjct: 848 LIKLQD-----ENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVL 902
Query: 1171 GDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK 1230
+ E+ L R D + Q + + S +L E
Sbjct: 903 QTSSTGNEAGGVNSNQFEELLQER-DTLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 961
Query: 1231 DELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK 1290
+LQA+ + L+ + L YE T L++ + Q++ ++ Q N K
Sbjct: 962 HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNF----GQELAQVQHSIGQLCNTK 1017
Query: 1291 YDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLA 1350
D ++++ + + +++ E +E + L+ A
Sbjct: 1018 -DLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDA 1076
Query: 1351 KLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM-RIAHDKD--VKNKDA 1407
+ S + ++ D++++ ++K D + ++ +KD +K K
Sbjct: 1077 TIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSD 1136
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE 1467
+L + + + +T LK E + LE + K E E++ Y E
Sbjct: 1137 QLLSSNENFTNKVNENELLRQAVTNLK----ERILILEMDIGKLKGENEKIVETYRGKET 1192
Query: 1468 EHVV---TKARLTVEKEQAQGELLHVQKELSTALGEI--KTLQEKLGTESAAWNTEKTEM 1522
E+ T + ++ + + E H KE + A ++ + Q K G + N K+
Sbjct: 1193 EYQALQETNMKFSMMLREKEFE-CHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQ 1251
Query: 1523 QNSIASLQER----LCGGGWEVERARL-NARLDQRERELRAANDRRDVLEHHHDXXXXXX 1577
+ ++ QER L ++E L N R++E R +N + L +H
Sbjct: 1252 EKTVVFQQERDQVMLALKQKQMENTALQNVVQRLRDKEFR-SNQELERLRNHLLESEDSY 1310
Query: 1578 XXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQM 1637
D R +K+++ Q+ + + + Q
Sbjct: 1311 TREALAAED--REAKLRKKVTVLEEKLVSSSNAMENASHQA-SVQVESLQEQLNVVSKQR 1367
Query: 1638 NTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEY 1697
+ +L QV ++ N + +LE Q+ + + + + + + E
Sbjct: 1368 DETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENL 1427
Query: 1698 RNKVALLEQQVACLEDELCESRLLASKLNTEL-VSEKSSAEV-RLAEMQSRLNEYEEERL 1755
KV L++ CL DE + AS+L +L V E+ E+ R E++ + + +++L
Sbjct: 1428 EGKVISLQE---CL-DEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKL 1483
Query: 1756 LS---SGRARVAGLATRMELAWHKERDEQQR 1783
+S S +V + R H + QR
Sbjct: 1484 MSLANSSEGKVDKVLMRNLFIGHFHTPKNQR 1514
Score = 46.4 bits (105), Expect = 0.001
Identities = 113/624 (18%), Positives = 252/624 (40%), Gaps = 47/624 (7%)
Query: 271 DQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELT 330
+Q E L QE D L+++ +++E+ K ++ + + E+ +LQ +V +
Sbjct: 917 NQFEELLQERDTLKQQVKKMEEWKQQVM----TTVQNMQHESAQLQEELHQLQAQVLVDS 972
Query: 331 THNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENED 390
+N L+ + L Q + E++L+ + + Q++ +L + L L+ + +
Sbjct: 973 DNNSKLQVDYTGLIQSYEQNETKLK---NFGQELAQVQHSIGQLCNTKDL---LLGKLDI 1026
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
+ +L + R +++ S L+Q ++ +L+K+ ++ D +
Sbjct: 1027 ISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELE-------ELRKSLQEKDATIR 1079
Query: 451 EKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
E+ +L + + ++R+ ++ + E+ + E LQ+ L E + + L
Sbjct: 1080 TLQENNHRLSDSIAATSELERKEH-EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1138
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDS-LEREADLREQLRNAEEETANCKQV 569
+ + T KV+ + L R Q + +L++ L E D+ + L+ E+ +
Sbjct: 1139 LSSNENFTNKVNENELLR--------QAVTNLKERILILEMDIGK-LKGENEKIVETYRG 1189
Query: 570 NPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLS----IDK 625
+ Q T+ + + E E +S++ K + KE+ + L+ K
Sbjct: 1190 KETEYQALQE-TNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVK 1248
Query: 626 TTEETQFHFDLPYLSIFNHMAANNLRKTAAR-VEEDNESLLLQLKKMATKARSRKLSPTP 684
+ +E F + + + TA + V + + + + R+ L
Sbjct: 1249 SMQEKTVVFQQERDQVMLALKQKQMENTALQNVVQRLRDKEFRSNQELERLRNHLLESED 1308
Query: 685 PANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR--KVEELEQDKEALKKQV 742
+ ++ A D + K + E KL+ N E + +VE L++ + KQ
Sbjct: 1309 SYTREAL-AAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQR 1367
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCER 802
E ++S V++ + +L +E + E+++ ++ + E +++ E
Sbjct: 1368 DETALQLS-VSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAEN 1426
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ 862
L ++ Q+ + +LD++ + L QL V E++ L+ + E E L
Sbjct: 1427 LEGKVISLQECLDEA--NAALDSASR----LTEQLDVKEEQIEELKRQN---ELRQEMLD 1477
Query: 863 TENKKLQLLKNAKSLRSDKALDLN 886
KKL L N+ + DK L N
Sbjct: 1478 DVQKKLMSLANSSEGKVDKVLMRN 1501
Score = 45.2 bits (102), Expect = 0.002
Identities = 146/747 (19%), Positives = 290/747 (38%), Gaps = 47/747 (6%)
Query: 151 NGSQTQLAITKNDSLAERVRKMQLLKTQNSFEKEPSIEKERERRS--------LSKSKED 202
N + ++ K D E+ R QL + KE ++KE+ +S L+K K +
Sbjct: 238 NEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLE 297
Query: 203 EKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLV 262
+K D+ + +++ N +Q +N +++
Sbjct: 298 DKVENLVDQLNKSQES-NVSIQKENLELKEHIRQNEEE-LSRIRNELMQSLNQDSNSNFK 355
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
D+ +KE + ++ LKQ + L + E ++K D+ + + A + + E L
Sbjct: 356 DTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMEN-EKLVLACEDVRHQLEECLAG 414
Query: 323 QQKVN-ELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQLR-AKLLAAET 379
+++ E T E L+ EK + ++ + LE E ++ R A +
Sbjct: 415 NNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQL 474
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSL--RRELEQTIKNCRVLSFK 437
E L+ N+ E+ +L M + +E + SSL +++L Q I + K
Sbjct: 475 EHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK 534
Query: 438 LK----KTERKADQLEQEKAEHE--KKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
LK K + + D+ Q ++E ++ +E G +E L++E+ R E
Sbjct: 535 LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN-NHLQEELERLRE---E 590
Query: 492 LQRELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLTRGGSQ--EDPAQLLRDLQDSLER 548
R A+ K S L +V Q T+K + + ED Q L SL+
Sbjct: 591 QSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQE 650
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAS 608
+ ++ R E+ + FL+K ++ I + +T + + + S
Sbjct: 651 QKKEMDEFRYQHEQ---MNATHTQLFLEKDEEIKSLQK-TIEQIKTQLHEERQDIQTDNS 706
Query: 609 TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAAR-VEEDNESLLLQ 667
+ K S L+I+ +E+ DL + R+ + + E N SL Q
Sbjct: 707 DIFQETKVQS--LNIENGSEK----HDLSKAETERLVKGIKERELEIKLLNEKNISLTKQ 760
Query: 668 LKKMATKARSRKLSPTPPANKLSIET--ANDNDEKETDEADPAEMKLLLELNEQEA--TV 723
+ ++ +K KL+ L I+ A + T + + +L E+E V
Sbjct: 761 IDQL-SKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAV 819
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L K E K K + + +K +++ K + + R ++ + E ++ L
Sbjct: 820 LNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTR-FESSGQDMFRETIQNLS 878
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKT-LIKSRSLDASDQQNVDLKRQLQVIEQ 842
I E ++ + C+ L A L + + + S + Q+ LK+Q++ +E+
Sbjct: 879 RIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDTLKQQVKKMEE 938
Query: 843 EASVLRAKTQSLEADNEKLQTENKKLQ 869
+ Q+++ ++ +LQ E +LQ
Sbjct: 939 WKQQVMTTVQNMQHESAQLQEELHQLQ 965
>AL391602-1|CAI12788.3| 1661|Homo sapiens novel protein protein.
Length = 1661
Score = 68.9 bits (161), Expect = 2e-10
Identities = 86/372 (23%), Positives = 168/372 (45%), Gaps = 45/372 (12%)
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
EEL EN+ +K E+ +L M+D + E+ + LR++L+Q K CR+L ++L+K
Sbjct: 219 EELRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKA 278
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI-KELEQEVARSTEVALRLQRELAEAN 500
ER++ + Q + + +L+ G++++ ++ K++ + + EV + + L E N
Sbjct: 279 ERRSLRAAQ-TGQVDGELIR------GLEQDVKVSKDISMRLHKELEVVEKKRARLEEEN 331
Query: 501 SKFTGS--NPSLMK-VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
+ L K V Q E + SL + G++ + L E ADL+ QL
Sbjct: 332 EELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQ--EDSADLKCQLH 389
Query: 558 NAEEETA-NCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKS 616
A+EE+A CK+ L K ++ + ++ + ++ + + + S++E +
Sbjct: 390 FAKEESALMCKK------LTKLAKENDSMKEELLKYRSLYGDLDSAL-------SAEELA 436
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
D+P + ET+ L + AN L + +E +N L ++ M +
Sbjct: 437 DAP------HSRETELKVHLKLV----EEEANLLSRRIVELEVENRGLRAEMDDM----K 482
Query: 677 SRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE 736
P +L+ + E+ AE++ L+ E+EA +LRR ELE +
Sbjct: 483 DHGGGCGGPEARLAFSALGGGECGES----LAELRRHLQFVEEEAELLRRSSAELEDQNK 538
Query: 737 ALKKQVKELTSK 748
L ++ + S+
Sbjct: 539 LLLNELAKFRSE 550
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/244 (22%), Positives = 117/244 (47%), Gaps = 17/244 (6%)
Query: 639 LSIFNHMAANNLRKTAARVEEDNESLLLQL--KKMATKARSRKLS-PTPPA-NKLSIETA 694
+S+ H + K AR+EE+NE L +L ++A + +L P + K +
Sbjct: 309 ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSL 368
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
D+K + D A++K L ++E+ ++ +K+ +L ++ +++K+++ + S +
Sbjct: 369 GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDS 428
Query: 755 T-SAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKK 813
SA A S T + +K++E+E + + ++++E E + L AE+ +
Sbjct: 429 ALSAEELADAPHSRETE----LKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDH 484
Query: 814 ------PKTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
P+ + +L + + +L+R LQ +E+EA +LR + LE N+ L E
Sbjct: 485 GGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNEL 544
Query: 866 KKLQ 869
K +
Sbjct: 545 AKFR 548
Score = 38.3 bits (85), Expect = 0.28
Identities = 41/169 (24%), Positives = 75/169 (44%), Gaps = 11/169 (6%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGA--KRITELKQ 1435
KEL L+ ER+ L ++ K + E A LKG +E +G GA + + K
Sbjct: 989 KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKA 1048
Query: 1436 EYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ-KEL 1494
+ ++ +H LA + ELT + ++ E K +L VE+ Q + + + Q KEL
Sbjct: 1049 ALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQL-VERLQGEKQQVEQQVKEL 1107
Query: 1495 STALGEIKTLQE-------KLGTESAAWNTEKTEMQNSIASLQERLCGG 1536
L +++ + +L + +W ++E + ++ E GG
Sbjct: 1108 QNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGG 1156
Score = 35.5 bits (78), Expect = 2.0
Identities = 63/279 (22%), Positives = 126/279 (45%), Gaps = 26/279 (9%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE 841
L+DEI+E+R +++E RD ++ E + Q + + LD + + L+ +L+ E
Sbjct: 228 LKDEIEELRAEMLEM-RD---VYMEEDVYQLQE----LRQQLDQASKTCRILQYRLRKAE 279
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
+ + LRA Q+ + D E ++ + +++ K+ S+R K L++ KK +LE E +E
Sbjct: 280 RRS--LRA-AQTGQVDGELIRGLEQDVKVSKDI-SMRLHKELEVVEKKRARLEEENEELR 335
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
++ E E+ K+V TE + +LK + + L
Sbjct: 336 QRLIETEL-------AKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQL 388
Query: 962 KSLKDDAQKSFK--PRIPKKPTDLTTK-LQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
K+++ K ++ K+ + + L+ + + DL+ + + +A S +E
Sbjct: 389 HFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSA--EELADAPHS-RETE 445
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
K L K ++E + LS+ E E L+ E+ +KD
Sbjct: 446 LKVHL-KLVEEEANLLSRRIVELEVENRGLRAEMDDMKD 483
>AL132768-4|CAI21460.3| 1661|Homo sapiens novel protein protein.
Length = 1661
Score = 68.9 bits (161), Expect = 2e-10
Identities = 86/372 (23%), Positives = 168/372 (45%), Gaps = 45/372 (12%)
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
EEL EN+ +K E+ +L M+D + E+ + LR++L+Q K CR+L ++L+K
Sbjct: 219 EELRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKA 278
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI-KELEQEVARSTEVALRLQRELAEAN 500
ER++ + Q + + +L+ G++++ ++ K++ + + EV + + L E N
Sbjct: 279 ERRSLRAAQ-TGQVDGELIR------GLEQDVKVSKDISMRLHKELEVVEKKRARLEEEN 331
Query: 501 SKFTGS--NPSLMK-VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
+ L K V Q E + SL + G++ + L E ADL+ QL
Sbjct: 332 EELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQ--EDSADLKCQLH 389
Query: 558 NAEEETA-NCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKS 616
A+EE+A CK+ L K ++ + ++ + ++ + + + S++E +
Sbjct: 390 FAKEESALMCKK------LTKLAKENDSMKEELLKYRSLYGDLDSAL-------SAEELA 436
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
D+P + ET+ L + AN L + +E +N L ++ M +
Sbjct: 437 DAP------HSRETELKVHLKLV----EEEANLLSRRIVELEVENRGLRAEMDDM----K 482
Query: 677 SRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE 736
P +L+ + E+ AE++ L+ E+EA +LRR ELE +
Sbjct: 483 DHGGGCGGPEARLAFSALGGGECGES----LAELRRHLQFVEEEAELLRRSSAELEDQNK 538
Query: 737 ALKKQVKELTSK 748
L ++ + S+
Sbjct: 539 LLLNELAKFRSE 550
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/244 (22%), Positives = 117/244 (47%), Gaps = 17/244 (6%)
Query: 639 LSIFNHMAANNLRKTAARVEEDNESLLLQL--KKMATKARSRKLS-PTPPA-NKLSIETA 694
+S+ H + K AR+EE+NE L +L ++A + +L P + K +
Sbjct: 309 ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSL 368
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
D+K + D A++K L ++E+ ++ +K+ +L ++ +++K+++ + S +
Sbjct: 369 GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDS 428
Query: 755 T-SAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKK 813
SA A S T + +K++E+E + + ++++E E + L AE+ +
Sbjct: 429 ALSAEELADAPHSRETE----LKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDH 484
Query: 814 ------PKTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
P+ + +L + + +L+R LQ +E+EA +LR + LE N+ L E
Sbjct: 485 GGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNEL 544
Query: 866 KKLQ 869
K +
Sbjct: 545 AKFR 548
Score = 38.3 bits (85), Expect = 0.28
Identities = 41/169 (24%), Positives = 75/169 (44%), Gaps = 11/169 (6%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGA--KRITELKQ 1435
KEL L+ ER+ L ++ K + E A LKG +E +G GA + + K
Sbjct: 989 KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKA 1048
Query: 1436 EYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ-KEL 1494
+ ++ +H LA + ELT + ++ E K +L VE+ Q + + + Q KEL
Sbjct: 1049 ALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQL-VERLQGEKQQVEQQVKEL 1107
Query: 1495 STALGEIKTLQE-------KLGTESAAWNTEKTEMQNSIASLQERLCGG 1536
L +++ + +L + +W ++E + ++ E GG
Sbjct: 1108 QNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGG 1156
Score = 35.5 bits (78), Expect = 2.0
Identities = 63/279 (22%), Positives = 126/279 (45%), Gaps = 26/279 (9%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE 841
L+DEI+E+R +++E RD ++ E + Q + + LD + + L+ +L+ E
Sbjct: 228 LKDEIEELRAEMLEM-RD---VYMEEDVYQLQE----LRQQLDQASKTCRILQYRLRKAE 279
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
+ + LRA Q+ + D E ++ + +++ K+ S+R K L++ KK +LE E +E
Sbjct: 280 RRS--LRA-AQTGQVDGELIRGLEQDVKVSKDI-SMRLHKELEVVEKKRARLEEENEELR 335
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
++ E E+ K+V TE + +LK + + L
Sbjct: 336 QRLIETEL-------AKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQL 388
Query: 962 KSLKDDAQKSFK--PRIPKKPTDLTTK-LQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
K+++ K ++ K+ + + L+ + + DL+ + + +A S +E
Sbjct: 389 HFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSA--EELADAPHS-RETE 445
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
K L K ++E + LS+ E E L+ E+ +KD
Sbjct: 446 LKVHL-KLVEEEANLLSRRIVELEVENRGLRAEMDDMKD 483
>AL079335-1|CAI42289.3| 1661|Homo sapiens novel protein protein.
Length = 1661
Score = 68.9 bits (161), Expect = 2e-10
Identities = 86/372 (23%), Positives = 168/372 (45%), Gaps = 45/372 (12%)
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
EEL EN+ +K E+ +L M+D + E+ + LR++L+Q K CR+L ++L+K
Sbjct: 219 EELRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKA 278
Query: 442 ERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI-KELEQEVARSTEVALRLQRELAEAN 500
ER++ + Q + + +L+ G++++ ++ K++ + + EV + + L E N
Sbjct: 279 ERRSLRAAQ-TGQVDGELIR------GLEQDVKVSKDISMRLHKELEVVEKKRARLEEEN 331
Query: 501 SKFTGS--NPSLMK-VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
+ L K V Q E + SL + G++ + L E ADL+ QL
Sbjct: 332 EELRQRLIETELAKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQ--EDSADLKCQLH 389
Query: 558 NAEEETA-NCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKS 616
A+EE+A CK+ L K ++ + ++ + ++ + + + S++E +
Sbjct: 390 FAKEESALMCKK------LTKLAKENDSMKEELLKYRSLYGDLDSAL-------SAEELA 436
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
D+P + ET+ L + AN L + +E +N L ++ M +
Sbjct: 437 DAP------HSRETELKVHLKLV----EEEANLLSRRIVELEVENRGLRAEMDDM----K 482
Query: 677 SRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE 736
P +L+ + E+ AE++ L+ E+EA +LRR ELE +
Sbjct: 483 DHGGGCGGPEARLAFSALGGGECGES----LAELRRHLQFVEEEAELLRRSSAELEDQNK 538
Query: 737 ALKKQVKELTSK 748
L ++ + S+
Sbjct: 539 LLLNELAKFRSE 550
Score = 61.7 bits (143), Expect = 3e-08
Identities = 56/244 (22%), Positives = 117/244 (47%), Gaps = 17/244 (6%)
Query: 639 LSIFNHMAANNLRKTAARVEEDNESLLLQL--KKMATKARSRKLS-PTPPA-NKLSIETA 694
+S+ H + K AR+EE+NE L +L ++A + +L P + K +
Sbjct: 309 ISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREHSLKKRGTRSL 368
Query: 695 NDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTK 754
D+K + D A++K L ++E+ ++ +K+ +L ++ +++K+++ + S +
Sbjct: 369 GKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDS 428
Query: 755 T-SAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKK 813
SA A S T + +K++E+E + + ++++E E + L AE+ +
Sbjct: 429 ALSAEELADAPHSRETE----LKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDH 484
Query: 814 ------PKTLIKSRSLDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
P+ + +L + + +L+R LQ +E+EA +LR + LE N+ L E
Sbjct: 485 GGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNEL 544
Query: 866 KKLQ 869
K +
Sbjct: 545 AKFR 548
Score = 38.3 bits (85), Expect = 0.28
Identities = 41/169 (24%), Positives = 75/169 (44%), Gaps = 11/169 (6%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGA--KRITELKQ 1435
KEL L+ ER+ L ++ K + E A LKG +E +G GA + + K
Sbjct: 989 KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKA 1048
Query: 1436 EYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ-KEL 1494
+ ++ +H LA + ELT + ++ E K +L VE+ Q + + + Q KEL
Sbjct: 1049 ALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQL-VERLQGEKQQVEQQVKEL 1107
Query: 1495 STALGEIKTLQE-------KLGTESAAWNTEKTEMQNSIASLQERLCGG 1536
L +++ + +L + +W ++E + ++ E GG
Sbjct: 1108 QNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGG 1156
Score = 35.5 bits (78), Expect = 2.0
Identities = 63/279 (22%), Positives = 126/279 (45%), Gaps = 26/279 (9%)
Query: 782 LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE 841
L+DEI+E+R +++E RD ++ E + Q + + LD + + L+ +L+ E
Sbjct: 228 LKDEIEELRAEMLEM-RD---VYMEEDVYQLQE----LRQQLDQASKTCRILQYRLRKAE 279
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
+ + LRA Q+ + D E ++ + +++ K+ S+R K L++ KK +LE E +E
Sbjct: 280 RRS--LRA-AQTGQVDGELIRGLEQDVKVSKDI-SMRLHKELEVVEKKRARLEEENEELR 335
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
++ E E+ K+V TE + +LK + + L
Sbjct: 336 QRLIETEL-------AKQVLQTELERPREHSLKKRGTRSLGKADKKTLVQEDSADLKCQL 388
Query: 962 KSLKDDAQKSFK--PRIPKKPTDLTTK-LQLKKMVEDLECEIGEMYVVMKNAGLSGKEMT 1018
K+++ K ++ K+ + + L+ + + DL+ + + +A S +E
Sbjct: 389 HFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSA--EELADAPHS-RETE 445
Query: 1019 AKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
K L K ++E + LS+ E E L+ E+ +KD
Sbjct: 446 LKVHL-KLVEEEANLLSRRIVELEVENRGLRAEMDDMKD 483
>AB033337-1|BAB69456.1| 1820|Homo sapiens mitotic kinesin-related
protein protein.
Length = 1820
Score = 68.9 bits (161), Expect = 2e-10
Identities = 162/870 (18%), Positives = 337/870 (38%), Gaps = 61/870 (7%)
Query: 280 VDILRKRCERVEKEKSDILLRRLANIDTA-NKYTTGRSSEVLKLQQKVNELTTHNEDLRD 338
++ L+K+ +KEK + + + +Y R ++ + + E+ N + R
Sbjct: 580 IEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRL 639
Query: 339 EK-KHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRD 397
K L K E + +T+ +T + + E + + L D D+KK+
Sbjct: 640 AIFKDLVGKCDTREEAAKDICATKVETEETHNY----VGFEDIIDSLQDNVADIKKQAEI 695
Query: 398 LXXXXXXMQDNFREDQADE--YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEH 455
+ D E ++ ++ EL +T +LKK E ++D L QE
Sbjct: 696 AHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELKTS 755
Query: 456 EKKLL-------EIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNP 508
KK++ E++ D Q+E+ I E Q + E + + A+ +S N
Sbjct: 756 IKKIITQNQRIKELINIID--QKEDTINEF-QNLKSLMENTFKCN-DKADTSSLII--NN 809
Query: 509 SLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD----LQDSLEREADLREQLRNAEEETA 564
L+ E K S+S + + + +L +D + S+ + + E + +EE
Sbjct: 810 KLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRP 869
Query: 565 NCKQVNPPTFLDK--QVMTDNIVTCD--IHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
N ++ L + + + ++T + + + + +++H S EK +
Sbjct: 870 NIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKN--- 926
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANN-----LRKTAARVEEDNESL---LLQLKKMA 672
L++ K ++ Q ++D+ + + N + K + +E S+ + Q+K M
Sbjct: 927 LTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMH 986
Query: 673 TKARS-RKLSPTPPANKLSIETAND-NDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
TK R L + + + D ++ E D ++ LL V +++E
Sbjct: 987 TKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQE 1046
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
++ + ++ + + + K S+ + L KL E VK +DE + ++
Sbjct: 1047 PNREN-SFHSSIEAIWEECKEIVKASSKKSHQIEE-LEQQIEKLQAE-VKGYKDENNRLK 1103
Query: 791 KKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK 850
+K + + D + E + Q K + K+ +LD Q V+ KR L + Q + +AK
Sbjct: 1104 EKEHKNQDDLLK-EKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAK 1162
Query: 851 TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMI 910
+ LE E + E L+ + L L + + + L++++ K+L +
Sbjct: 1163 IKELETILETQKVERSHSAKLEQDILEKESIILKLE-RNLKEFQEHLQDSVKNTKDLN-V 1220
Query: 911 CQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQK 970
+ + E+ + T + L+ K+ A ++LK D Q
Sbjct: 1221 KELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQ- 1279
Query: 971 SFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEM-TAKTKLEKEID 1028
R + DL KL KK ++ ++ E+ M K + E+ K + +E+D
Sbjct: 1280 ----RKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELD 1335
Query: 1029 EIRSKLSKNDSEFTNEK--NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+ + + + N+K +Q KD+N K + + + LE + Q
Sbjct: 1336 MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVK----EKIIEDMRMTLEEQEQTQVEQ 1391
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+ L +++ E +L + L+T
Sbjct: 1392 DQVLEAKLEEVERLATELEKWKEKCNDLET 1421
Score = 55.2 bits (127), Expect = 2e-06
Identities = 124/641 (19%), Positives = 252/641 (39%), Gaps = 66/641 (10%)
Query: 472 ENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS 531
EN +K ++E A + + Q+EL+ + K + + ++ + ++ + + +
Sbjct: 895 ENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKN 954
Query: 532 QEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHE 591
QE ++++ S E E R N + +++ LD NI ++ +
Sbjct: 955 QEQEEKIMKL---SNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRD 1011
Query: 592 --SETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN 649
+ + +++ N + K I + E FH + +I+
Sbjct: 1012 LSNGSEEDNLPNTQLDLLGNDYLVSKQVKE-YRIQEPNRENSFHSSIE--AIWEE--CKE 1066
Query: 650 LRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE 709
+ K +++ E L Q++K+ + + K N+L E + N + E +
Sbjct: 1067 IVKASSKKSHQIEELEQQIEKLQAEVKGYK----DENNRLK-EKEHKNQDDLLKEKETLI 1121
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
+L EL E+ T L +++ + + K AL + + +T + + + T
Sbjct: 1122 QQLKEELQEKNVT-LDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILET-------- 1172
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTL-IKSRSLDASDQ 828
K+ LE +I E +++ ER+ + L + K K L +K L
Sbjct: 1173 --QKVERSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEIT 1230
Query: 829 Q---NV-DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
Q N+ D+K LQ+ E+E R +T+ L+ E+L + + Q LK + + D
Sbjct: 1231 QLTNNLQDMKHLLQLKEEEEETNRQETEKLK---EELSASSARTQNLKADLQRKEEDYAD 1287
Query: 885 LNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
L K T + K+ + ++++ + +DE +++ E KK+ +
Sbjct: 1288 LKEKLT-----DAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMK----- 1337
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK-KMVEDLEC--EIG 1001
Q T++ LK+ ++ L +K K++ED+ E
Sbjct: 1338 -------------QRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQ 1384
Query: 1002 EMYVVMKNAGLSGKEMTAK---TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDV 1058
E V ++ L K + T+LEK ++ +KN+ E + KL ++
Sbjct: 1385 EQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNL 1444
Query: 1059 NAKL-EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNRE 1098
+L E ++ A++ K LE E L Q K E ++N+E
Sbjct: 1445 QDELQESEQKYNADRKKWLE-EKMMLITQAKE-AENIRNKE 1483
Score = 54.0 bits (124), Expect = 5e-06
Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 23/302 (7%)
Query: 1384 LQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE-QNSGAGAKRITELKQEYEET-- 1440
L+ ER + D KD + LK K +I + N+ K + +LK+E EET
Sbjct: 1195 LKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNR 1254
Query: 1441 --VKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
+KL+ L+ A + L + EE++ K +LT K+Q + VQKE+S
Sbjct: 1255 QETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQ----IKQVQKEVSVMR 1310
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEM---QNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
E K L+ K+ N E+ Q +I L+E+L +VE A + Q ER
Sbjct: 1311 DEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL--NNQKVEEA-----IQQYERA 1363
Query: 1556 LRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXI 1615
+ N + ++E + ++V + + +
Sbjct: 1364 CKDLNVKEKIIE----DMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1419
Query: 1616 EQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI 1675
E R + + T G++ ++DEL+ + + R++ K ML K I
Sbjct: 1420 ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENI 1479
Query: 1676 KN 1677
+N
Sbjct: 1480 RN 1481
Score = 41.1 bits (92), Expect = 0.039
Identities = 105/543 (19%), Positives = 211/543 (38%), Gaps = 37/543 (6%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
+ + E LK+E+ R + + K+D+ + D K T + ++ ++Q++V+ +
Sbjct: 1254 RQETEKLKEELSASSARTQNL---KADLQRKEEDYADLKEKLTDAKK-QIKQVQKEVSVM 1309
Query: 330 TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQI---EQLRAKLLAAETLCEELMD 386
++ LR + L +K + EL+ + T Q ++ +++ + E C++L
Sbjct: 1310 RDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNV 1369
Query: 387 EN---EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ EDM+ L + QD E + +E L ELE+ + C L K +
Sbjct: 1370 KEKIIEDMRMTLEEQEQTQVE-QDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN 1428
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTE------VALRLQRELA 497
K + + L + + + +R K LE+++ T+ + + ++ A
Sbjct: 1429 KEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYA 1488
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQL---LRDLQDSLEREADLRE 554
E +F + + T K S R + A L L+ L S ++ + E
Sbjct: 1489 EDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIE 1548
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMT---DNIVTCDIHES-ETVTNSIQNKMIHAASTP 610
QL+ ET+ + K++ + D + T + S E N I++ + S
Sbjct: 1549 QLKRIISETSKI-ETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCE 1607
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+S E S K E QF P H ++ + + ++++
Sbjct: 1608 ASTENDQS--TRFPKPELEIQFTPLQPNKMAVKHPGCTT--PVTVKIPKARKRKSNEMEE 1663
Query: 671 MATKARSRKLSPTPPAN-KLSI-ETANDNDEKETDEADPAEMKLLLELNEQEATV----- 723
K ++K + TP N K I + N + +KE A K L Q + +
Sbjct: 1664 DLVKCENKK-NATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLA 1722
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
++K L++ + L+ L SK + +T + S + + N ++ + K+
Sbjct: 1723 TKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYT 1782
Query: 784 DEI 786
EI
Sbjct: 1783 SEI 1785
Score = 35.1 bits (77), Expect = 2.6
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 15/165 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+K+ Q ++ ++ E +LR + +EK+K+ +D + T + E L QK
Sbjct: 1299 IKQVQKEVSVMRDEDKLLRIKINELEKKKNQC----SQELDMKQR-TIQQLKEQLN-NQK 1352
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
V E E + + I ++ LE + T+ + Q+ L AKL E L EL
Sbjct: 1353 VEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQV--LEAKLEEVERLATEL- 1409
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQAD---EYSSLRRELEQT 427
E K++ DL + E+ D + ++L+ EL+++
Sbjct: 1410 ---EKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQES 1451
>AB002371-1|BAA20828.2| 1540|Homo sapiens KIAA0373 protein.
Length = 1540
Score = 68.9 bits (161), Expect = 2e-10
Identities = 164/807 (20%), Positives = 341/807 (42%), Gaps = 81/807 (10%)
Query: 318 EVLKLQQKVNELTTHNE-DLRDEK-KHLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
++ LQ+ V+ + +E +L +++ LT K R+I L+ +T +E L + +
Sbjct: 6 KIAALQKVVDNSVSLSELELANKQYNELTAKYRDI---LQKDNMLVQRTSNLEHLECENI 62
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
+ + E + E E K++L + +E + SS+ + +++I N ++S
Sbjct: 63 SLKEQVESINKELEITKEKLHTIEQAWE------QETKLGNESSMDKA-KKSITNSDIVS 115
Query: 436 FKLKKTERKADQL-EQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
K T + +L E+++AEH +K+ E + Q E R ELE + A T++ L Q+
Sbjct: 116 ISKKITMLEMKELNERQRAEHCQKMYEHLR-TSLKQMEERNFELETKFAELTKINLDAQK 174
Query: 495 ELAEANSKFTGS-NPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD-L 552
+ S + ++ + +++ ++ + + LR++ D R+ + L
Sbjct: 175 VEQMLRDELADSVSKAVSDADRQRILELEKNEM----ELKVEVSKLREISDIARRQVEIL 230
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDN-IVTCDIHESETVTNSIQNKMIHAASTPS 611
Q ++ ++E + + LD Q +D + +H+ + + + +
Sbjct: 231 NAQQQSRDKEVESLRM----QLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESIT 286
Query: 612 SK-EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
SK +K ++ L +++ +E + L Y + A +LR+T +SL Q
Sbjct: 287 SKLQKMEAYNLRLEQKLDEKEQA--LYYARLEGRNRAKHLRQTI-------QSLRRQFSG 337
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE 730
A+ K S T I+ ND ++K++ E+ + R +E
Sbjct: 338 ALPLAQQEKFSKT------MIQLQND------------KLKIMQEMKNSQQE--HRNMEN 377
Query: 731 LEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR-RSLTTNSNKLAEERVKVLEDEIDEV 789
+ E K ++EL S + N + L KL E VK E EI +
Sbjct: 378 KTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKE-EIKYL 436
Query: 790 RKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRA 849
+ E ER L E+ + Q K + R + A DQ+ VDL+RQL + +++ + +
Sbjct: 437 NNIISEYERTISSLEEEI-VQQNK---FHEERQM-AWDQREVDLERQLDIFDRQQNEILN 491
Query: 850 KTQSLEADNEKLQTENKKL--QLLKNAKSLRSDKALDLNTKKTTQ-LENEL--KEALAKI 904
Q E + + L QL + ++ + + L T+ T + LE +L KE+ ++
Sbjct: 492 AAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRL 551
Query: 905 KELEMICQDEK-SEKKVRFTEATKKETDTLK-SKQXXXXXXXXXXXXXXXXXXXXQATLK 962
E ++ +D+ +E ++R ++E + ++ QA L
Sbjct: 552 AEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLN 611
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
K++ K ++ R+ +K + ++ +KK EDL + + ++ L+ + TA
Sbjct: 612 Q-KEEVLKKYQ-RLLEKAREEQREI-VKKHEEDLHI-LHHRLELQADSSLNKFKQTAWDL 667
Query: 1023 LEKEIDEIRS-----KLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALE 1077
+++ + + +L++ + + + L + + KLK V+ LE +++ K K E
Sbjct: 668 MKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFE 727
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKL 1104
N L + +E+K +A++ L
Sbjct: 728 NIKLQLQENHE---DEVKKVKAEVEDL 751
Score = 63.3 bits (147), Expect = 9e-09
Identities = 170/870 (19%), Positives = 360/870 (41%), Gaps = 80/870 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
++ V E D + L ++ + + ER ++E +++ ++ NI + EV K
Sbjct: 687 MEQTVAEQDDSLSSLLVKLKKVSQDLER-QREITELKVKEFENIKL--QLQENHEDEVKK 743
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE--- 378
++ +V +L + + E + L ++ + + E +R T +E+L+++L E
Sbjct: 744 VKAEVEDLKYLLDQSQKESQCLKSEL-QAQKEANSRAPTTTMRNLVERLKSQLALKEKQQ 802
Query: 379 -TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ--ADEYS-SLRRELEQTIKNCRVL 434
L L++ +M + ++ Q D ++ L+ ++E +N L
Sbjct: 803 KALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKL 862
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
LK ++ + + L + +L + + + RE +E++QE + E+ +++R
Sbjct: 863 KEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREK--EEIDQE---NDELKRQIKR 917
Query: 495 ELAEANSK-FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
+ K T + SL++ Q + K+ + + ++ ++ L R + +
Sbjct: 918 LTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGK 977
Query: 554 EQLRNAEEETANCKQVNPPTF-LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
+ E K+ F L KQ+ T + + E +T +Q K+ T
Sbjct: 978 KWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKA-DKEKLT--LQRKLKTTGMTVD- 1033
Query: 613 KEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN-ESLLLQLKKM 671
+ L +K EE + +L + +M A+ + VE+ + ++ LQ K
Sbjct: 1034 -QVLGIRALESEKELEELKKR-NLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 1091
Query: 672 ATKARSRKLSPTPPANKLSIETANDNDEKETD--------EADPAEMKLLLELNEQEATV 723
A + + K + + P+ +S ++D+ ++E + ++ E+K LE ++
Sbjct: 1092 ALEKQFSKDTYSKPS--ISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPR 1149
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L+ +V +L++ E LKK+ E+ K+ V GS S K E K +
Sbjct: 1150 LKNQVRDLKEMCEFLKKEKAEVQRKLGHV----RGSG---------RSGKTIPELEKTI- 1195
Query: 784 DEIDEVRKKLIEK-ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIE- 841
+ KK++EK +R+ E+L KK ++ S + +Q+N LK +L+ ++
Sbjct: 1196 ----GLMKKVVEKVQRENEQL--------KKASGILTSEKMANIEQENEKLKAELEKLKA 1243
Query: 842 ----QEASVLRAKTQSLE---ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
Q + +KT+ E A+NE+L+ E KK + + LN K T QLE
Sbjct: 1244 HLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLE 1303
Query: 895 NELKE-ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
K A+ + ++ D KS K + T + + L++
Sbjct: 1304 ETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKE 1363
Query: 954 XXXXQATLKSLKDDAQKSFK-----PRIPKKPTDLTTKLQLKKMV-EDLECEIGEM-YVV 1006
+ + +D ++ K P + L +LQ+ ++ L+ E E+ + +
Sbjct: 1364 ATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQI 1423
Query: 1007 MKNAGLSGKEMTA--KTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
N SG E T +L+++I ++ ++L +D E + K ++ +L++ +
Sbjct: 1424 EANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE 1483
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEM 1094
+ + YK +N L + K L+E++
Sbjct: 1484 EIEDLKYNYKEEVKKNILLEEKVKKLSEQL 1513
Score = 52.8 bits (121), Expect = 1e-05
Identities = 158/868 (18%), Positives = 347/868 (39%), Gaps = 82/868 (9%)
Query: 273 IEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTH 332
I + +++ +L + E E+++++ + ++ T+ K R+ E L+ K ELT
Sbjct: 113 IVSISKKITMLEMK-ELNERQRAEHCQKMYEHLRTSLKQMEERNFE---LETKFAELTKI 168
Query: 333 NEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD------ 386
N D + ++ L ++ + S+ + + + ++E+ +L + E+ D
Sbjct: 169 NLDAQKVEQMLRDELADSVSKAVSDADRQ-RILELEKNEMELKVEVSKLREISDIARRQV 227
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYS----------SLRRELEQTIKNCRVLSF 436
E + +++ RD MQ + Q+DE S SL+ + ++
Sbjct: 228 EILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITS 287
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
KL+K E +LEQ+ E E+ L +G R +++ Q + R AL L ++
Sbjct: 288 KLQKMEAYNLRLEQKLDEKEQALY--YARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQE 345
Query: 497 AEANSKFTGSNPSL-----MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
+ + N L MK Q E + +L + +L+ L+D+ +
Sbjct: 346 KFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKV 405
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMT--DNIVTCDIHESETVTNSIQNKMIHAAST 609
+ ++ E K +N DK+ + +NI++ E E +S++ +++
Sbjct: 406 INWHMKIEELRLQELK-LNRELVKDKEEIKYLNNIIS----EYERTISSLEEEIVQQNKF 460
Query: 610 PSSKEKS-DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
++ + D + +++ + FD I N AA + + + + L QL
Sbjct: 461 HEERQMAWDQREVDLERQLDI----FDRQQNEILN--AAQKFEEATGSIPDPSLPLPNQL 514
Query: 669 KKMATKARSR-KLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRK 727
+ K + ++ A S+E KE + A + +L ++ + R
Sbjct: 515 EIALRKIKENIRIILETRATCKSLE----EKLKEKESALRLAEQNILSRDKVINELRLRL 570
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
E++K + KE+ K K + T A N + ++ + L ++
Sbjct: 571 PATAEREKLIAELGRKEMEPKSHHTLKIA--HQTIANMQARLNQKEEVLKKYQRLLEKAR 628
Query: 788 EVRKKLIEK-ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDL---KRQLQVIEQE 843
E ++++++K E D LH L L K + D Q + K +++ E E
Sbjct: 629 EEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEME 688
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
+V + SL + KL+ ++ L+ + L+ + ++ + E+E+K+ A+
Sbjct: 689 QTVAE-QDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAE 747
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSK-QXXXXXXXXXXXXXXXXXXXXQATLK 962
+++L+ + + ++KE+ LKS+ Q +
Sbjct: 748 VEDLKYLL------------DQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQL 795
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-- 1020
+LK+ QK+ + + ++T + ++++ K A L+ +++ +
Sbjct: 796 ALKEKQQKALSRALLELRAEMTAAAE-ERIISATS---------QKEAHLNVQQIVDRHT 845
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVF---ANKYKALE 1077
+L+ +++++ L K KNR + L D+N +L+ + + + + ++
Sbjct: 846 RELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEID 905
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLS 1105
EN L Q K LT ++ + NK S
Sbjct: 906 QENDELKRQIKRLTSGLQGKPLTDNKQS 933
Score = 42.3 bits (95), Expect = 0.017
Identities = 144/762 (18%), Positives = 319/762 (41%), Gaps = 73/762 (9%)
Query: 189 KERERRSLSKSKED---EKTARYKDE--RSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPX 243
KE+++++LS++ + E TA ++ ++++ + + +Q R++ LK V
Sbjct: 798 KEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNE 857
Query: 244 XXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDIL--LRR 301
+ N+ + ++++ ++ + + + E +++E ++ ++R
Sbjct: 858 NLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKR 917
Query: 302 LANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE 361
L + T + S + +LQ+KV +L E +E K + + EL +
Sbjct: 918 LTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGK 977
Query: 362 AQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLR 421
+IE +R KL ++ + E+ L ++D F + ++ +L+
Sbjct: 978 KWQAKIEGIRNKL--------------KEKEGEVFTLTKQLNTLKDLFAKADKEKL-TLQ 1022
Query: 422 RELEQT-IKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQ 480
R+L+ T + +VL + ++E++ ++L++ + E +L + + R++ +++L
Sbjct: 1023 RKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDIL-YMRAHQALPRDSVVEDLHL 1081
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVP-----------QPETVKVSRSSLTRG 529
+ E L+++ SK T S PS+ + Q E +K+S ++
Sbjct: 1082 QNRYLQEKLHALEKQF----SKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 1137
Query: 530 GSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANC-KQVNPPTFLDKQVMTDNIVTCD 588
E Q +DL + DL+E ++E A +++ + T +
Sbjct: 1138 FQLE---QANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKT 1194
Query: 589 IHESETVTNSIQ--NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMA 646
I + V +Q N+ + AS + EK +I++ E+ + + + + ++
Sbjct: 1195 IGLMKKVVEKVQRENEQLKKASGILTSEKM----ANIEQENEKLKAELEKLKAHLGHQLS 1250
Query: 647 ANNLRKT--AARVEEDNESLLLQLKK---MATKARSRKLSPTPPANKLSI---ETAN--- 695
+ KT ++ +NE L +LKK A K R K + K+++ ET
Sbjct: 1251 MHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQ 1310
Query: 696 --DNDEKETDEADPAEMK--LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS 751
++ + + AD K ++ + E + L + + Q LK+ VKE T +
Sbjct: 1311 FAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQK 1370
Query: 752 VTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLH-AELSLA 810
V K + + E+ +K E ++ + ++KE+ E +H E +
Sbjct: 1371 VNKYNEDLEQQIKILKHVPEGAETEQGLK-RELQVLRLANHQLDKEK-AELIHQIEANKD 1428
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE-NKKLQ 869
Q ++ I D ++ DL+ QL++ + E L+ + + L+ + E ++++
Sbjct: 1429 QSGAESTIP--DADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIE 1486
Query: 870 LLK-NAK-SLRSDKALDLNTKK-TTQLENELKEALAKIKELE 908
LK N K ++ + L+ KK + QL EL +A +E E
Sbjct: 1487 DLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFE 1528
Score = 38.3 bits (85), Expect = 0.28
Identities = 59/274 (21%), Positives = 110/274 (40%), Gaps = 17/274 (6%)
Query: 188 EKERERRSLSK---SKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGGPXX 244
E ER R+ L K + E + A+ E + K V K + + + P + G
Sbjct: 1266 ENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSK 1325
Query: 245 XXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN 304
+++++ + I LKQ V +R ++V K D+ +
Sbjct: 1326 SWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQ---- 1381
Query: 305 IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
I G +E L++++ L N L EK L I +IE+ + + E+
Sbjct: 1382 IKILKHVPEGAETEQ-GLKRELQVLRLANHQLDKEKAEL---IHQIEANKD-QSGAESTI 1436
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
+QL+ K+ ET + E + +K+E++ L +NF +E L+
Sbjct: 1437 PDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKEL----ENFDPSFFEEIEDLKYNY 1492
Query: 425 EQTIKNCRVLSFKLKK-TERKADQLEQEKAEHEK 457
++ +K +L K+KK +E+ +L A E+
Sbjct: 1493 KEEVKKNILLEEKVKKLSEQLGVELTSPVAASEE 1526
Score = 36.3 bits (80), Expect = 1.1
Identities = 47/173 (27%), Positives = 83/173 (47%), Gaps = 14/173 (8%)
Query: 1394 MRIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK-QEYEETVKKLEHSLALE 1451
+R+A ++ V +D L++L KLK + Q+ + ITELK +E+E +L+ + E
Sbjct: 682 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLER-QREITELKVKEFENIKLQLQENHEDE 740
Query: 1452 ----KAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEK 1507
KAE E+L + ++E K+ L +KE + L L L+EK
Sbjct: 741 VKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEK 800
Query: 1508 LGTESAAWNTEKTEMQNSI-ASLQERLCGGGWEVERARLNAR--LDQRERELR 1557
+ A + E++ + A+ +ER+ + E A LN + +D+ REL+
Sbjct: 801 ---QQKALSRALLELRAEMTAAAEERIISATSQKE-AHLNVQQIVDRHTRELK 849
Score = 33.9 bits (74), Expect = 6.0
Identities = 26/117 (22%), Positives = 60/117 (51%), Gaps = 14/117 (11%)
Query: 1429 RITELKQEYEETVKKLEHSLALEKAEYEELTGKY-ELLEEEHVVTKARLTVEKEQAQG-- 1485
+I L++ + +V E L L +Y ELT KY ++L++++++ + +E + +
Sbjct: 6 KIAALQKVVDNSVSLSE--LELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENIS 63
Query: 1486 ---ELLHVQKELSTALGEIKTLQE------KLGTESAAWNTEKTEMQNSIASLQERL 1533
++ + KEL ++ T+++ KLG ES+ +K+ + I S+ +++
Sbjct: 64 LKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKI 120
Score = 33.5 bits (73), Expect = 7.9
Identities = 41/160 (25%), Positives = 72/160 (45%), Gaps = 13/160 (8%)
Query: 1625 EITDTKTRYEGQMNTMRDELKSLHNQVS-RFRRERDNYKQMLE--AAQKSMAE-IKNGDK 1680
EI + ++E ++ D L NQ+ R+ ++N + +LE A KS+ E +K +
Sbjct: 488 EILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKES 547
Query: 1681 SARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRL 1740
+ R+ +I S D+ N++ L + A E E + L ++ + A +
Sbjct: 548 ALRLAEQNILSRDK--VINELRL--RLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTI 603
Query: 1741 AEMQSRLNEYEE-----ERLLSSGRARVAGLATRMELAWH 1775
A MQ+RLN+ EE +RLL R + + E H
Sbjct: 604 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLH 643
>Z11583-1|CAA77669.1| 2115|Homo sapiens NuMA protein protein.
Length = 2115
Score = 68.5 bits (160), Expect = 2e-10
Identities = 151/785 (19%), Positives = 309/785 (39%), Gaps = 53/785 (6%)
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK-NCRVLS 435
+ T EEL + K+E+R L + + +S ++ QT + R L
Sbjct: 161 SSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLK 220
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEVARSTEVALRLQR 494
+L D+LE E AE+ K L E MQ R +R+ L ++ A S L+
Sbjct: 221 KQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE- 279
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
EL + N T +K Q + +K +S + R +Q DL L A +
Sbjct: 280 ELRDKNESLTMRLHETLK--QCQDLKTEKSQMDRKINQLSEEN--GDLSFKLREFASHLQ 335
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS---IQNKMIHAASTPS 611
QL++A E +L+KQ + ++ + + + + +Q K+ S
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 612 SKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE-DNESLLLQLKK 670
+ D+PP + + L + +AANN + ARVE + E + K
Sbjct: 396 QLQ--DNPPQEKGEVLGDVLQLETLKQEAAT--LAANNTQ-LQARVEMLETERGQQEAKL 450
Query: 671 MATKAR----SRKLSPTPPANKLSIETANDNDEK--ETDEADPAEMKLLLELNEQEATVL 724
+A + ++LS + SI + E+ + +A A + + E T L
Sbjct: 451 LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL 510
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT--TNSNKLAEERVKVL 782
+++ +Q+ LK+Q KE ++++ + ++ R + ++S K E+++K +
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV 570
Query: 783 EDEIDEVRKKLIE-------------KERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
++ + R+ + +ERD E +K K I + L +++
Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQ--LLKNAKSLRSDKALDLNT 887
+ + ++E + L K + L+A E + E + Q + + LRS++
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++ Q +++L+E L +KE + + E+K R +A +++ + +
Sbjct: 691 ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH 750
Query: 948 XXXXXXXXXXQATLKSLKDDAQ---KSFKPRIPKKPTDLTTKLQLKKMVEDLECE--IGE 1002
+A K L+ Q ++ + +L + + E ECE + E
Sbjct: 751 KRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES-ECEQLVKE 809
Query: 1003 MYVVMKNAGLSGKE--------MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
+ + S +E L++E ++ R +L + + ++ + +I++
Sbjct: 810 VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR 869
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSL 1114
++ A+L + + + E L++ TL E+M ++ +L ++ A
Sbjct: 870 QQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQ 929
Query: 1115 QTTMS 1119
Q T S
Sbjct: 930 QETAS 934
Score = 68.5 bits (160), Expect = 2e-10
Identities = 161/842 (19%), Positives = 334/842 (39%), Gaps = 90/842 (10%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
L ++E +D+ E L + K+C+ ++ EKS + R++ + S E
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ-MDRKINQL----------SEENG 321
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
L K+ E +H + L+D LT+ E T+ E Q + ++L A L +
Sbjct: 322 DLSFKLREFASHLQQLQDALNELTE-----EHSKATQEWLEKQAQLEKELSAAL--QDKK 374
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
C L ++NE ++ +L L +QDN +++ + + +LE + L+ +
Sbjct: 375 C--LEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV-LQLETLKQEAATLAANNTQ 431
Query: 441 TERKADQLEQEKAEHEKKLLEIVG--GPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ + + LE E+ + E KLL G + Q + I +L+ ++ ++ L++
Sbjct: 432 LQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQA 491
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
++ T SL + + G ++ + L +L+++ + LR+
Sbjct: 492 HGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRH 551
Query: 559 -AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E+ +++ KQ K+V T H + T A +S + D
Sbjct: 552 QVEQLSSSLKQKEQQL---KEVAEKQEATRQDHAQQLAT--------AAEEREASLRERD 600
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
+ ++ +E ++ + AN R +A ++ + Q ++ + S
Sbjct: 601 AALKQLEALEKEKAAKLEILQQQL---QVANEARDSA-------QTSVTQAQREKAEL-S 649
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE---LEQD 734
RK+ + +ETA E+ +A AE++L L +Q+AT R +E L++
Sbjct: 650 RKVEEL----QACVETA--RQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
+ALK+ +K + + +A + +R + ++L E ++E E RK+L
Sbjct: 704 LQALKESLKVTKGSLEEEKRRAADALEEQQRCI----SELKAETRSLVEQHKRE-RKELE 758
Query: 795 EKERDCERLHAEL-SLAQ-KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK-- 850
E+ + L A L L + + +T + R L + + + + + +E + R +
Sbjct: 759 EERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYE 818
Query: 851 -TQSLEAD-----NEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
+Q EA E+L T ++ + + +K + + Q+ + E LA++
Sbjct: 819 DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNE-LAEL 877
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
+ EK+VR + + TL+ K TL
Sbjct: 878 HANLARALQQVQEKEVR-AQKLADDLSTLQEKMAATSKEVARL-----------ETLVRK 925
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE 1024
+ Q++ + K+P + E LE + G + A L E A+ ++
Sbjct: 926 AGEQQETASRELVKEPARAG-----DRQPEWLEEQQGRQF-CSTQAALQAMEREAE-QMG 978
Query: 1025 KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
E++ +R+ L ++ + E+ + + E+A+L + + D + LE N
Sbjct: 979 NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
Query: 1085 NQ 1086
N+
Sbjct: 1039 NE 1040
Score = 67.3 bits (157), Expect = 5e-10
Identities = 132/659 (20%), Positives = 271/659 (41%), Gaps = 63/659 (9%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEV-LKLQQKVNELT 330
++E L+Q V L+++ + EKE A+ A GR+ KL+ E++
Sbjct: 1079 ELEELRQTVKQLKEQLAKKEKEH--------ASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130
Query: 331 THNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENED 390
+ + +++ R +E+E +R ++ +E L+ +L E +EL
Sbjct: 1131 KLEQQCQKQQEQADSLERSLEAERASRAERDSA---LETLQGQL---EEKAQELGHSQSA 1184
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
+ R+L +QD+ + + + R E KN + S + + + LE+
Sbjct: 1185 LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEK 1244
Query: 451 EKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
E E K L + + E R++ L+ E A ++ A AE +S SL
Sbjct: 1245 EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA-------AERSSALREEVQSL 1297
Query: 511 MKVPQPETVKVS--RSSLTRGGSQ-EDPAQLLRDLQDSLEREADLREQLRNAEEET-ANC 566
+ + + V R LT + E+ Q L+ Q+ ++ L+ T A
Sbjct: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357
Query: 567 KQVNPPTFLDKQVMTDNIVT-----CDIHESETVTNSIQNKMIHAAS-----TPSSKEKS 616
++ P L +Q+ + ++ +S+ ++ +++ A P ++ +
Sbjct: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVA 1417
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
+ + E+ + L L + + A R R + L ++L + K
Sbjct: 1418 EQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYV 1477
Query: 677 SRKLSPTPPANKLSIETANDND------EKETDEADPAEMKLLLELN--EQEATVLRRKV 728
+ A E + E T + + A++K+L E ++E L +V
Sbjct: 1478 QELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV 1537
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
E+LE + KQV+EL+ K++ + S + +++ + L+ +++E
Sbjct: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE--SQQEAQRLQAQLNE 1595
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
++ +L +KE+ E H +L + +K KT DA QQN +L+ QL+ +EQ L+
Sbjct: 1596 LQAQLSQKEQAAE--HYKLQM--EKAKT-----HYDAKKQQNQELQEQLRSLEQ----LQ 1642
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
+ + L A+ E+L E ++ L K+ +++ T + LE ++ A ++++L
Sbjct: 1643 KENKELRAEAERLGHELQQAGL----KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
Score = 62.1 bits (144), Expect = 2e-08
Identities = 139/691 (20%), Positives = 285/691 (41%), Gaps = 59/691 (8%)
Query: 271 DQIEGLKQEVDILRKRCERVEKEKS---DILLRRL--AN--IDTANKYTTGRSSEVLKLQ 323
++ E +E D K+ E +EKEK+ +IL ++L AN D+A T E +L
Sbjct: 590 EEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESEL--ETRPSTEAQ--TRQIEQLRAKLLAAET 379
+KV EL E R E+ ++ E+E +L E + +TE + ++ +QL+ +L A +
Sbjct: 650 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKE 709
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ---ADEYSSLRRELEQTIKNCRVLSF 436
+ E+ K+ D + + +++ R+ELE+ + L
Sbjct: 710 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+L++ +A Q E E E L E + E+ ++L +EVA E Q+E
Sbjct: 770 RLQQL-GEAHQAETEVLRRE--LAEAMAAQH--TAESECEQLVKEVAAWRERYEDSQQEE 824
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRS-SLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
A+ + F +L + + ++ + G Q+ R + E A+L
Sbjct: 825 AQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARA 884
Query: 556 LRNAEEETANCKQV--NPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
L+ +E+ +++ + T +K T ++ ET+ + +S+
Sbjct: 885 LQQVQEKEVRAQKLADDLSTLQEKMAATSK----EVARLETLVRKAGEQ-----QETASR 935
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMAT 673
E P + D+ E + + S A + + A ++ + E L L +
Sbjct: 936 ELVKEPARAGDRQPEWLEEQQGRQFCS--TQAALQAMEREAEQMGNELERLRAALMESQG 993
Query: 674 KARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLE--LNEQE---ATV---LR 725
+ + + +L+ E + ++A AE+++ L+ LNEQ AT+ L
Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053
Query: 726 RKVEELE-QDKEALK------KQVKELTSKISSVTKTSAG-SNTTARRSLTTNSNKLAEE 777
+ E E +D+E K Q+KEL +V + + + + + A
Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV--DLKR 835
R + +++ +R ++ + E+ C++ + ++ + SR+ S + + L+
Sbjct: 1114 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 1173
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENK-----KLQLLKNAKSL-RSDKALDLNTKK 889
+ Q + S L + + L A K+Q +K K Q+ + + R + + ++
Sbjct: 1174 KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE 1233
Query: 890 TTQLENELKEALAKIKELE--MICQDEKSEK 918
+ L ++ E + KEL+ ++ + EKS+K
Sbjct: 1234 VSILNRQVLEKEGESKELKRLVMAESEKSQK 1264
Score = 58.8 bits (136), Expect = 2e-07
Identities = 191/1109 (17%), Positives = 422/1109 (38%), Gaps = 87/1109 (7%)
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSN 760
E A P E K L EL ++ ++ R E L+Q ++ LK + ++ KI+ +++ + G
Sbjct: 266 EKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD-LKTEKSQMDRKINQLSEEN-GDL 323
Query: 761 TTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKS 820
+ R ++ +L ++ + L +E + ++ +EK+ E+ ELS A + K L
Sbjct: 324 SFKLREFASHLQQL-QDALNELTEEHSKATQEWLEKQAQLEK---ELSAALQDKKCL--- 376
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD 880
+++N L+ +L +E+ S L+ + ++ + +L+ LK + +
Sbjct: 377 ------EEKNEILQGKLSQLEEHLSQLQDNPPQ---EKGEVLGDVLQLETLKQEAATLAA 427
Query: 881 KALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXX 940
L + LE E + AK+ ++EK + T+ ++ ++K+
Sbjct: 428 NNTQLQAR-VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE 486
Query: 941 XXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEI 1000
+ L +L Q+ + K + QL + ++ E
Sbjct: 487 QASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE--- 543
Query: 1001 GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
+ GL + + L+++ +++ K ++ + +L T A+ ++ +
Sbjct: 544 ------QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA-AEEREASL 596
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+ ++D + +ALE E + + + L ++++ + + A + +S
Sbjct: 597 R---ERDAALKQLEALEKEKAA---KLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650
Query: 1121 CMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXX 1180
+ +++ + +Q K + V + ++ +
Sbjct: 651 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKES 710
Query: 1181 XXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK 1239
K +E++ D + + L H+R EL E+ + +
Sbjct: 711 LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770
Query: 1240 TESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVE 1299
+ +AE L+ + + + + + + +K++ A R+ D E
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGA 829
Query: 1300 MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXX 1359
M + + + EL AK K+ E+ S +L++++ +++LA+L
Sbjct: 830 MFQEQLMTLKEECEKA--RQELQEAKEKVAGIESHS---ELQISRQQNELAELHANLARA 884
Query: 1360 XXXXXXXXXXSSYWENKAKELDTDLQSERKKL--DRMRIAHDKDVKNKDAELATLKGKLK 1417
E +A++L DL + ++K+ +A + + K E + +
Sbjct: 885 LQQVQEK-------EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASR-E 936
Query: 1418 ILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLT 1477
++++ + AG ++ L+++ + +L + E E++ + E L + ++ +
Sbjct: 937 LVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 996
Query: 1478 VEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGG- 1536
E+ Q + E+ + +E A ++ + E + A+LQE L
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1056
Query: 1537 ----GWEVERARLNA-------RLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXX 1585
G + E A+L L++ + ++ ++ E H
Sbjct: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE 1116
Query: 1586 DYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQS---EKARKAEITDTKTRYEGQMNTMRD 1642
+ R +E+S E+A +AE +GQ+
Sbjct: 1117 PTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQ 1176
Query: 1643 ELKSLHNQVSRFRRE----RDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
EL + ++ +RE R + +A + A++ G + A +NS+ S+ EEE
Sbjct: 1177 ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE-RKNSLISSLEEE-- 1233
Query: 1699 NKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
V++L +QV LE E ES+ L + E SEKS +++ RL + E +S
Sbjct: 1234 --VSILNRQV--LEKE-GESKELKRLVMAE--SEKSQ------KLEERLRLLQAETASNS 1280
Query: 1759 GRARVAGLATRMELAWHKERDEQQRLLQE 1787
RA A R E+ +E E+QR+ E
Sbjct: 1281 ARAAERSSALREEVQSLREEAEKQRVASE 1309
Score = 58.4 bits (135), Expect = 2e-07
Identities = 122/633 (19%), Positives = 265/633 (41%), Gaps = 63/633 (9%)
Query: 310 KYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIE 368
K T + +++ +QQ+++ L NE +++ E+ + E+ +T +Q +
Sbjct: 242 KLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE-PKELEELRDKNESLTMRLHETLKQCQ 300
Query: 369 QLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE-LEQT 427
L+ + + +L +EN D+ +LR+ +QD E +E+S +E LE+
Sbjct: 301 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNE-LTEEHSKATQEWLEKQ 359
Query: 428 IKNCRVLSFKL---KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
+ + LS L K E K + L+ + ++ E+ L ++ P + E L+ E +
Sbjct: 360 AQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLK 419
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ---LLRD 541
L AN+ + +++ + + + ++ RG +E+ Q L+ D
Sbjct: 420 QEAATL-------AANNTQLQARVEMLETERGQ--QEAKLLAERGHFEEEKQQLSSLITD 470
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
LQ S+ + +E+L A + + L ++ T N T + E
Sbjct: 471 LQSSISNLSQAKEELEQA-SQAHGARLTAQVASLTSELTTLN-ATIQQQDQEL------- 521
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQ-FHFDLPYLSIFNHMAANNLRKTAARVEED 660
A +KEK ++ + + +Q + LS L++ A + E
Sbjct: 522 ----AGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ +++AT A R+ S L A + ++ E ++++ E +
Sbjct: 578 RQD---HAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA 634
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
T V + +++K L ++V+EL + + TAR+ ++AE ++
Sbjct: 635 QT----SVTQAQREKAELSRKVEELQACVE-----------TARQEQHEAQAQVAELELQ 679
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD-LKRQLQV 839
+ ++ K+ + +E+D +L +L ++ K + SL+ ++ D L+ Q +
Sbjct: 680 LRSEQQKATEKERVAQEKD--QLQEQLQALKESLK--VTKGSLEEEKRRAADALEEQQRC 735
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
I S L+A+T+SL +++ + E ++ + + R + + + +T L EL E
Sbjct: 736 I----SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAE 791
Query: 900 ALAKIKELEMICQD---EKSEKKVRFTEATKKE 929
A+A E C+ E + + R+ ++ ++E
Sbjct: 792 AMAAQHTAESECEQLVKEVAAWRERYEDSQQEE 824
Score = 55.6 bits (128), Expect = 2e-06
Identities = 102/579 (17%), Positives = 220/579 (37%), Gaps = 40/579 (6%)
Query: 1225 ELTSEKDELQARFIKTESKFIT-LEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDAL 1283
ELT E + +++ +++ L A ++D K E K L+ ++ + H+ QL+D
Sbjct: 343 ELTEEHSKATQEWLEKQAQLEKELSAALQDKKC-LEEKNEILQGKLSQLEEHLSQLQDNP 401
Query: 1284 RQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL--E 1341
Q +K + +++ ++ Q A++++ +TE AKL E
Sbjct: 402 PQ---EKGEVLGDVLQLETLKQEAATLAANNTQLQ-----ARVEMLETERGQQEAKLLAE 453
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+ + +L + E ++ L ++ L +
Sbjct: 454 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
++ +D ELA LK + K + ++ + Q V++L SL ++ + +E+ K
Sbjct: 514 IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK 573
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
E ++H A E+E + E K+L E E L + N +
Sbjct: 574 QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
Q S+ Q E+A L+ ++++ + + A + +
Sbjct: 634 AQTSVTQAQR---------EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
+ ERV++ + +E+ EK R A+ + + R ++ ++
Sbjct: 685 QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE-EKRRAADALEEQQRC---ISELK 740
Query: 1642 DELKSLHNQVSRFRRERDNY---KQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
E +SL Q R R+E + ++ LEA + + E + + + +
Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 800
Query: 1699 NKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
++ L ++VA + +S+ E + + +L ++ + +E L
Sbjct: 801 SECEQLVKEVAAWRERYEDSQ-------QEEAQYGAMFQEQLMTLKEECEKARQE--LQE 851
Query: 1759 GRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+ +VAG+ + EL ++++E L + + LAR L+Q
Sbjct: 852 AKEKVAGIESHSELQISRQQNE---LAELHANLARALQQ 887
Score = 44.8 bits (101), Expect = 0.003
Identities = 99/550 (18%), Positives = 209/550 (38%), Gaps = 28/550 (5%)
Query: 1249 AEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXX 1308
A+ R + + E ++ + KD I ++ + + +A SP+E E+
Sbjct: 224 ADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRD 283
Query: 1309 XXXXXXXXXQDELNNAK-IKLEKTEAESSAAKLEMAQLKSDLA-KLENXXXXXXXXXXXX 1366
+ L + +K EK++ + +L ++ DL+ KL
Sbjct: 284 KNESLTMRLHETLKQCQDLKTEKSQMDRKINQL--SEENGDLSFKLRE---FASHLQQLQ 338
Query: 1367 XXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG 1426
+ E +K L+ ++ +L++ A +D K + + L+GKL LE++
Sbjct: 339 DALNELTEEHSKATQEWLE-KQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQL 397
Query: 1427 AKRITELKQEYEETVKKLE---HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEK--- 1480
+ K E V +LE A A +L + E+LE E +A+L E+
Sbjct: 398 QDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF 457
Query: 1481 EQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEV 1540
E+ + +L + +L +++ + +E+L S A T S+ S L +
Sbjct: 458 EEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQ 517
Query: 1541 ERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXX 1600
++ + +E++ + A + + +++ ++
Sbjct: 518 DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577
Query: 1601 XXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDN 1660
E S + R A + + E +L+ L Q+ RD+
Sbjct: 578 RQDHAQQLATAAEEREASLRERDAAL----KQLEALEKEKAAKLEILQQQLQVANEARDS 633
Query: 1661 YKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRL 1720
+ + AQ+ AE+ + + + + ++ E + +VA LE Q+ + + E
Sbjct: 634 AQTSVTQAQREKAELSRKVEELQACVET-ARQEQHEAQAQVAELELQLRSEQQKATEKER 692
Query: 1721 LA---SKLNTELVSEKSSAEV---RLAEMQSRLNE--YEEERLLSSGRARVAGLATRMEL 1772
+A +L +L + K S +V L E + R + E++R +S +A L + +
Sbjct: 693 VAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR 752
Query: 1773 AWHKERDEQQ 1782
KE +E++
Sbjct: 753 E-RKELEEER 761
Score = 42.7 bits (96), Expect = 0.013
Identities = 84/404 (20%), Positives = 155/404 (38%), Gaps = 32/404 (7%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E RK L+ +S E+E SI + +SKE ++ + E+S ++ L+Q +
Sbjct: 1219 EAERKNSLI---SSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAE 1275
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
+ NS + + ++ E L QE+ +++
Sbjct: 1276 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK 1335
Query: 287 CERVEKEKSDILLRRLANIDTANKYTTGRS-SEVLKLQQKVNELTTHNEDLRDEKK---- 341
+ E+ S + L + ++ + + L+ +Q E H E+L K+
Sbjct: 1336 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE-KRHREELEQSKQAAGG 1394
Query: 342 ---HLTQKIREIESELETRPSTEAQTRQIEQLRA-KLLAAETL-----CEELMDENEDMK 392
L + RE+ + R Q R +QLRA K AE L L+ E
Sbjct: 1395 LRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGL 1454
Query: 393 KELRDLXXXXXXMQ-DNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
E +L ++ D RE E +++R + E + + ++ + A +LE
Sbjct: 1455 GERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ------REAQSTARELEVM 1508
Query: 452 KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLM 511
A++E ++++ Q E ++L +V EV R Q + E SK +
Sbjct: 1509 TAKYEGAKVKVLEERQRFQEER--QKLTAQV-EQLEVFQREQTKQVEELSKKLADSDQAS 1565
Query: 512 KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
KV Q + V +GG + AQ L+ + L+ + +EQ
Sbjct: 1566 KVQQQKLKAVQ----AQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605
Score = 37.9 bits (84), Expect = 0.37
Identities = 67/319 (21%), Positives = 122/319 (38%), Gaps = 26/319 (8%)
Query: 1233 LQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
LQ + +F TL+ + + E K L + IK+LE+ LRQT +
Sbjct: 1034 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE-LRQTVKQLKE 1092
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK- 1351
+ E + E K++ + E + + Q ++D +
Sbjct: 1093 QLAKK----EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLER 1148
Query: 1352 -LENXXXXXXXXXXXXXXXSSYWENKAKEL---DTDLQSERKKLDRMRIAHDKDVKNKDA 1407
LE E KA+EL + L S +++L R K +D
Sbjct: 1149 SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1208
Query: 1408 ELATL-KGKLKILEQNSGAGA--KRITELKQ---EYEETVKKLEHSLALEKAEYEELTGK 1461
A + +G+ + +NS + + ++ L + E E K+L+ + E + ++L +
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER 1268
Query: 1462 YELLEEEHVVTKARLTV------EKEQAQGELLHVQKELSTALGEIKTLQ----EKLGTE 1511
LL+ E AR E+ Q+ E Q+ S L + T Q E+LG E
Sbjct: 1269 LRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328
Query: 1512 SAAWNTEKTEMQNSIASLQ 1530
AW + + + ++++LQ
Sbjct: 1329 LKAWQEKFFQKEQALSTLQ 1347
>U53445-1|AAA98972.1| 752|Homo sapiens DOC1 protein.
Length = 752
Score = 68.5 bits (160), Expect = 2e-10
Identities = 99/463 (21%), Positives = 203/463 (43%), Gaps = 36/463 (7%)
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK----ETDEAD-PA 708
A ED+++ LQ K A + +L T + + + E D EK E A A
Sbjct: 71 AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 130
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
E++ L+++ EQ + +R E Q K+ K +V++L+ +I ++ K N + + +
Sbjct: 131 EVEELIKMEEQCRDLNKRLERETLQSKD-FKLEVEKLSKRIMALEKLEDAFNKSKQECYS 189
Query: 769 TNSNKLAEERV--KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDAS 826
N L +ER+ K L E++ ++ ++ E E RL + K+ T +K+ ++
Sbjct: 190 LKCN-LEKERMTTKQLSQELESLKVRIKELEAIESRLE-KTEFTLKEDLTKLKTLTVMFV 247
Query: 827 DQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN 886
D++ + +L+ E + L+A + L+ + K+ T +KL + + ++L+S ++
Sbjct: 248 DERKT-MSEKLKKTEDK---LQAASSQLQVEQNKVTTVTEKL-IEETKRALKSKTDVEEK 302
Query: 887 TKKTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
T+ ++LK L +E +++ + + +++ EA +K+ K Q
Sbjct: 303 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 362
Query: 945 XXXXXXXXXXXXXQAT---------LKSLKDDAQKSFKP--RIPKKPTDLTTKLQ-LKKM 992
Q +K+++DD K+ + ++ + K Q L K
Sbjct: 363 ALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKE 422
Query: 993 VEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEI 1052
+E ++ E+ + + K E + + L K + E +K E K ++ +
Sbjct: 423 LEHVKMELAKYKLAEKT------ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYM 476
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
A +D+ L+GD V K EN N +L + + LT+E++
Sbjct: 477 AT-EDLICHLQGDHSVCKKKLNQQENRNRDLGREIENLTKELE 518
Score = 46.4 bits (105), Expect = 0.001
Identities = 72/381 (18%), Positives = 161/381 (42%), Gaps = 20/381 (5%)
Query: 739 KKQVKELTSKISSV-TKTS-AGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEK 796
+++++ELT+ TK + A + T K + + + D + KL +
Sbjct: 17 RQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNE 76
Query: 797 ERDCERLHAELSLAQKKPKTLIKS-RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLE 855
+ +L +L+ ++ L ++ RSL ++++ D+K ++ E + + A+ + L
Sbjct: 77 DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELI 136
Query: 856 ADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEK 915
E+ + NK+L+ + +S ++ +K+ LE +L++A K K+ E
Sbjct: 137 KMEEQCRDLNKRLE-RETLQSKDFKLEVEKLSKRIMALE-KLEDAFNKSKQ-ECYSLKCN 193
Query: 916 SEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK---DDAQKSF 972
EK+ T+ +E ++LK + LK+L D +K+
Sbjct: 194 LEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTM 253
Query: 973 KPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK-EMTAKT-KLEKEIDEI 1030
++ K L ++ ++ + E + L K ++ K + KE D++
Sbjct: 254 SEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDL 313
Query: 1031 RSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG-DKDVFANKYKALENENSNL----SN 1085
++KL + + N L + + LK+ LE +KD NK +++ +N
Sbjct: 314 KNKLKAEE----EKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENN 369
Query: 1086 QCKTLTEEMKNREAQINKLSA 1106
+ K L++E++ + ++ + A
Sbjct: 370 KIKELSQEVERLKLKLKDMKA 390
Score = 43.6 bits (98), Expect = 0.007
Identities = 108/535 (20%), Positives = 213/535 (39%), Gaps = 36/535 (6%)
Query: 357 RPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADE 416
R + T ++ KL AE +E + ++KEL+ QD +E
Sbjct: 17 RQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNE 76
Query: 417 YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
S R+L+Q + +L++T R + E+E + ++K+ + G G+ E ++
Sbjct: 77 -DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE--VE 133
Query: 477 ELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA 536
EL + + ++ RL+RE ++ F L K + + + S+++
Sbjct: 134 ELIKMEEQCRDLNKRLERETLQSKD-FKLEVEKLSK----RIMALEKLEDAFNKSKQECY 188
Query: 537 QLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
L +L+ L ++L + + + + + L+K T + E T
Sbjct: 189 SLKCNLEKERMTTKQLSQELESLKVRIKELEAIE--SRLEKTEFT-------LKEDLTKL 239
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR--KTA 654
++ + T S K K L + + + + ++ + R K+
Sbjct: 240 KTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN---KVTTVTEKLIEETKRALKSK 296
Query: 655 ARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLL 714
VEE S+ + + K ++ + +++++ N E E D + KL
Sbjct: 297 TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQ 355
Query: 715 ELNEQEATVLR--RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
+ + + + K++EL Q+ E LK ++K++ + + KT T RR N
Sbjct: 356 DSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERR--YANER 413
Query: 773 KLAEERVKVLEDEIDEVRK-KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
A+ K LE E+ K KL EK L +++ K+ SR +DA ++
Sbjct: 414 DKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIH 473
Query: 832 DLKRQLQVI---EQEASVLRAKTQSLEADNEKL--QTEN--KKLQLLKN-AKSLR 878
+ +I + + SV + K E N L + EN K+L+ ++ +KSLR
Sbjct: 474 EYMATEDLICHLQGDHSVCKKKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 528
Score = 41.9 bits (94), Expect = 0.022
Identities = 98/545 (17%), Positives = 214/545 (39%), Gaps = 41/545 (7%)
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKA-DYENKITSLESTIAAK 1272
++ + +RL+ +LT ++ ++Q + T +K + + + + + E K T LE + +
Sbjct: 1 MVVDEQQRLTAQLTLQRQKIQE--LTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQ 58
Query: 1273 DVHIKQLEDALR-QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXX---XQDELNNAKIKL 1328
Q +D + + TN+ ++ + ++EL + K K+
Sbjct: 59 TTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI 118
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
K E ++ E+ +L K+E S ++ + ++L + +
Sbjct: 119 SKGEYGNAGIMAEV----EELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 174
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
K D + + K L + K L Q + RI EL + E ++K E +L
Sbjct: 175 KLEDAFNKSKQECYSLK-CNLEKERMTTKQLSQELESLKVRIKEL-EAIESRLEKTEFTL 232
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ + + LT + + E + + K + T +K QA L V++ ++ T+ EKL
Sbjct: 233 KEDLTKLKTLTVMF-VDERKTMSEKLKKTEDKLQAASSQLQVEQN------KVTTVTEKL 285
Query: 1509 GTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEH 1568
E+ KT+++ + S+ + ER D + +L+A ++ + L
Sbjct: 286 IEETKRALKSKTDVEEKMYSVTK---------ER-------DDLKNKLKAEEEKGNDLLS 329
Query: 1569 HHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITD 1628
+ D+ + +K+ + ++ E+ K ++ D
Sbjct: 330 RVNMLKNRLQSLEAIEKDFLK-NKLNQDSGKSTTALHQENNKIKELSQEVERL-KLKLKD 387
Query: 1629 TKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNS 1688
K + M T DE ++L + + R + + LE + +A+ K +K+ H
Sbjct: 388 MKAIEDDLMKT-EDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQW 446
Query: 1689 ISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLN 1748
+ +EE K L ++V L++++ E + L L + S + +L + ++R
Sbjct: 447 LFKRLQEE-EAKSGHLSREVDALKEKIHE-YMATEDLICHLQGDHSVCKKKLNQQENRNR 504
Query: 1749 EYEEE 1753
+ E
Sbjct: 505 DLGRE 509
Score = 41.5 bits (93), Expect = 0.030
Identities = 45/204 (22%), Positives = 87/204 (42%), Gaps = 11/204 (5%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+N KE ++ + V ++ R+EKE + + DT T S+ +LQ
Sbjct: 25 TNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ 84
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
QK+ L+ ++L + + L + E++ E E I +L+ E C +
Sbjct: 85 QKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELIKMEEQCRD 144
Query: 384 LMD-------ENEDMKKELRDLX---XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRV 433
L +++D K E+ L ++D F + + + Y SL+ LE+ +
Sbjct: 145 LNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECY-SLKCNLEKERMTTKQ 203
Query: 434 LSFKLKKTERKADQLEQEKAEHEK 457
LS +L+ + + +LE ++ EK
Sbjct: 204 LSQELESLKVRIKELEAIESRLEK 227
Score = 37.1 bits (82), Expect = 0.64
Identities = 49/224 (21%), Positives = 98/224 (43%), Gaps = 21/224 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK---- 321
+++ +D KQE L+ E+ E+ + L + L ++ K S + K
Sbjct: 173 LEKLEDAFNKSKQECYSLKCNLEK-ERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 231
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L++ + +L T DE+K +++K+++ E +L+ S Q+EQ + T+
Sbjct: 232 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQ----LQVEQNKVT-----TVT 282
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+L++E + K D+ + R+D ++ + + + +L +L+
Sbjct: 283 EKLIEETKRALKSKTDVEEKMYSVTKE-RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL 341
Query: 442 ER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
E + D L+ + + K + Q N+IKEL QEV R
Sbjct: 342 EAIEKDFLKNKLNQDSGKSTTALH-----QENNKIKELSQEVER 380
>AL139421-1|CAI22508.1| 1454|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 1454
Score = 68.5 bits (160), Expect = 2e-10
Identities = 182/881 (20%), Positives = 357/881 (40%), Gaps = 82/881 (9%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGR----SSEVL 320
N +E + K++V ++ E+V+ E+ +IL R L N + NK R SE+
Sbjct: 244 NAEELSKAFQQYKKKV---AEKLEKVQAEE-EILERNLTNCEKENKRLQERCGLYKSELE 299
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAET 379
L++K+ +L N + +++ + + K E+ ++L E+R S ++E + ++L +
Sbjct: 300 ILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELEN-KDEILRDKF 358
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK-- 437
LM+EN ++K + Q + E SL + + Q + FK
Sbjct: 359 ---SLMNENRELKVRVAAQNERLDLCQQEIESSRV-ELRSLEKIISQLPLKRELFGFKSY 414
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELA 497
L K + + ++++ + ++V ++ + IKE E + + A +L + L
Sbjct: 415 LSKYQMSSFSNKEDRCIGCCEANKLVISE--LRIKLAIKEAEIQKLHANLTANQLSQSLI 472
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
N S S ++ E VK+ GG Q + + + + E + + +
Sbjct: 473 TCNDSQESSKLSSLET---EPVKL-------GGHQVESVKDQNQHTMNKQYEKERQRLVT 522
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
EE Q+ K M + + + + K +++ S K
Sbjct: 523 GIEELRTKLIQIEAENSDLKVNMAHRT-----SQFQLIQEELLEKASNSSKLESEMTKKC 577
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
S L+++K EE + ++ +AA N + + E NE + + T+
Sbjct: 578 SQLLTLEKQLEEK--------IVAYSSIAAKNA-ELEQELMEKNEKIRSLETNINTEHEK 628
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEA 737
L+ A K+ +E + EK+ + + K + EQE T+ L+QD
Sbjct: 629 ICLA-FEKAKKIHLEQHKEM-EKQIERLEAQLEKKDQQFKEQEKTM-----SMLQQDIIC 681
Query: 738 LKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV--LEDEIDEVRKKLI- 794
+ ++ L ++ N +L N+++EE +KV L+ ++ +++L+
Sbjct: 682 KQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVL 741
Query: 795 ---------EK-ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
EK E+ ++ E+ QK+ K IK+ SL + +QNV L+ LQ +Q
Sbjct: 742 HLNQLEGNKEKFEKQLKKKSEEVYCLQKELK--IKNHSLQETSEQNVILQHTLQQQQQML 799
Query: 845 SVLRAKTQSLEADNEKLQTENKKL-QLLKNAKSLRSDKALDLNTK-KTTQLENELKEALA 902
+ LE KL+ + KL Q L+ + ++K + K ++ E +LK
Sbjct: 800 QQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR--Q 857
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
K+ EL + K E E +K E + + K+ K
Sbjct: 858 KVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEK 917
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE-DLECEIGEMYVVMKN-AGLSGKEMTAK 1020
K +A K + T+LT LQ ++++E +L+ GE+ ++ L A+
Sbjct: 918 --KTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQ 975
Query: 1021 TKLEKE---IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE------GDKDVFAN 1071
LE++ I ++ ++L + E ++K L LK+ N +L+ D+
Sbjct: 976 LSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIR 1035
Query: 1072 KYKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
+++ +E + L + E+K QI L+ L+NA
Sbjct: 1036 EHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNA 1076
Score = 68.5 bits (160), Expect = 2e-10
Identities = 148/853 (17%), Positives = 361/853 (42%), Gaps = 69/853 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
K+Y+ + + L ++ LR + ++E E SD+ ++ A+ R+S+ +Q+++
Sbjct: 511 KQYEKERQRLVTGIEELRTKLIQIEAENSDL------KVNMAH-----RTSQFQLIQEEL 559
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
E +++ L E ++ +E +LE + + AK E +ELM+
Sbjct: 560 LEKASNSSKLESEMTKKCSQLLTLEKQLEEK------IVAYSSIAAKNAELE---QELME 610
Query: 387 ENEDMKKELRDLXXXXXXM---QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+NE ++ ++ + + ++ +++ + +++E+ + K+ E+
Sbjct: 611 KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEK 670
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
L+Q+ + L + D + E++ E+++E + E LQ +++E K
Sbjct: 671 TMSMLQQDIICKQHHLESL----DRLLTESK-GEMKKENMKKDEALKALQNQVSEETIKV 725
Query: 504 TGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEET 563
+ S +++ + E V + G ++ QL + ++ + +L+ + ++ +ET
Sbjct: 726 RQLD-SALEICKEEL--VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK-NHSLQET 781
Query: 564 ANCKQVNPPTFLDKQVM--TDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
+ + T +Q M + I ++ +++T +K+ +E S
Sbjct: 782 SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKL--EQELQKQRESSAEKLR 839
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+++ E DL + L TA +V+ + + +L KM + K
Sbjct: 840 KMEEKCESAAHEADLKRQKVI------ELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 893
Query: 682 PTPPANKLS-IETANDNDEKETDEADPA--EMKLLLELNEQEATVLRRKVEELEQDKEAL 738
A LS ++ D + E ++ A E++ L E E T +K E LE + +
Sbjct: 894 GENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNA 953
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
++K ++ + + + TT + AE ++ + EI++ +++L+E ++
Sbjct: 954 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAE--LRECKMEIEDKKQELLEMDQ 1011
Query: 799 DCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADN 858
+ + EL + + LD + +++ Q ++I+ E ++ +++ + L+ N
Sbjct: 1012 ALKERNWELK------QRAAQVTHLDMTIREHRGEMEQ-KIIKLEGTLEKSELE-LKECN 1063
Query: 859 EKLQTENKKLQLLKNAKSLRSDKALDL-NTKKTTQLENELKEALAKIKELEMICQDEKSE 917
+++++ N KLQ K + LR + + L N ++ +QL+ E++ ++KE+E + ++++
Sbjct: 1064 KQIESLNDKLQNAK--EQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQY 1121
Query: 918 KKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ--KSFKPR 975
++ EA + L+ + Q ++ L + + K
Sbjct: 1122 IATQYKEAIDLGQE-LRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKE 1180
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLS 1035
L +L K V + E M +K LS + + K E+ + +
Sbjct: 1181 KDAHGNHLAEELGASK-VREAHLE-ARMQAEIKK--LSAEVESLKEAYHMEMISHQENHA 1236
Query: 1036 KNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
K ++K+ +Q +L+ +LE +D +N ++ +++ N + + E +
Sbjct: 1237 KWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVI----EAANEALL 1292
Query: 1096 NREAQINKLSADL 1108
+E+++ +L A +
Sbjct: 1293 TKESELTRLQAKI 1305
Score = 65.7 bits (153), Expect = 2e-09
Identities = 178/963 (18%), Positives = 365/963 (37%), Gaps = 81/963 (8%)
Query: 649 NLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPA 708
+LR+ ++ + N L+ Q + TK S T K+S+ + +
Sbjct: 115 SLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQ 174
Query: 709 EMKLLLELNEQEATVLRRKVEELEQ------DKEALKKQVKE--LTSKISSVTKTSAGSN 760
+ L E++ Q+ VLR +LEQ +KE ++ KE + K+ + +T G
Sbjct: 175 IINLEAEVSAQDK-VLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKR 233
Query: 761 TTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKS 820
+R+ + AEE K + +V +KL + + + E L L+ +K+ K L +
Sbjct: 234 AERQRNEALYN---AEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQER 290
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE-NKKLQLLKNAKSLRS 879
L S+ + LK +L+ +++E + + K + + N ++ + + Q + +S
Sbjct: 291 CGLYKSELEI--LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELE 348
Query: 880 DKALDLNTKKTTQLEN-ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
+K L K + EN ELK +A E +CQ E +V K + ++
Sbjct: 349 NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKREL 408
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC 998
+ + + + RI + +++K+ +L
Sbjct: 409 FGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKL----AIKEAEIQKLHANLTA 464
Query: 999 -EIGEMYVVMKNAGLSGKEMTAKTKLEK----EIDEIRSKLSKN-DSEFTNEKNRLQTEI 1052
++ + + ++ S K + +T+ K +++ ++ + + ++ E+ RL T I
Sbjct: 465 NQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGI 524
Query: 1053 AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNAT 1112
+L+ ++E + L+ ++ ++Q + + EE+ + + +KL +++
Sbjct: 525 EELRTKLIQIEAEN-------SDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKC 577
Query: 1113 SLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN-----YTKIDQDKNKLLKEVGDKT 1167
S T+ + + + T I+ + K+ +K
Sbjct: 578 SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAF-EKA 636
Query: 1168 KKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH-RRLSIEL 1226
KKI +R+E QL +KD+ Q ++ H L L
Sbjct: 637 KKI--HLEQHKEMEKQIERLEAQLE-KKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLL 693
Query: 1227 TSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLE---DAL 1283
T K E++ +K + L+ ++ + ++LE +H+ QLE +
Sbjct: 694 TESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKF 753
Query: 1284 RQTTNDKYDEATSPVEMVEMRXXXXXXXX-------------XXXXXQDELNNAKIKLEK 1330
+ K +E + ++++ Q+ + N +++ +
Sbjct: 754 EKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQ 813
Query: 1331 TEAESSAAKLEMAQLK------SDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL 1384
T+ E +KLE K L K+E A+++ ++
Sbjct: 814 TKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEM 873
Query: 1385 QSERKKLDRM--RIAH-DKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV 1441
+++L +M I H +D +NK L+ L IL+Q K+ +K+ +
Sbjct: 874 DQYKEELSKMEKEIMHLKRDGENKAMHLSQLD---MILDQTKTELEKKTNAVKE-----L 925
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEI 1501
+KL+HS + E E K E+LE E L Q Q EL V ++ +L E
Sbjct: 926 EKLQHS---TETELTEALQKREVLETELQNAHGELKSTLRQLQ-ELRDVLQKAQLSLEEK 981
Query: 1502 KTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEV-ERARLNARLDQRERELRAAN 1560
T + L E E + + + + + L WE+ +RA LD RE R
Sbjct: 982 YTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEM 1041
Query: 1561 DRR 1563
+++
Sbjct: 1042 EQK 1044
Score = 62.9 bits (146), Expect = 1e-08
Identities = 182/966 (18%), Positives = 383/966 (39%), Gaps = 108/966 (11%)
Query: 650 LRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANK-LSIETANDN-DEKETDEA-- 705
L++ +++E+N + +L+ MA K T L +E+ +N DE D+
Sbjct: 301 LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSL 360
Query: 706 --DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
+ E+K+ + + + ++++E + +L+K + +L K + + +
Sbjct: 361 MNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK----RELFGFKSYLS 416
Query: 764 RRSLTTNSNKLAEER-VKVLEDE---IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK 819
+ +++ SNK E+R + E I E+R KL KE + ++LHA L+ Q +
Sbjct: 417 KYQMSSFSNK--EDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITC 474
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSL----EADNEKLQTENKKLQL-LKNA 874
+ S ++S +++ + Q SV ++ E + ++L T ++L+ L
Sbjct: 475 NDSQESSKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI 534
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK 934
++ SD +++ +T+Q + +E L K + + E ++K + K+ + +
Sbjct: 535 EAENSDLKVNM-AHRTSQFQLIQEELLEKASNSSKL-ESEMTKKCSQLLTLEKQLEEKIV 592
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE 994
+ ++ ++ + +K K L +++K +E
Sbjct: 593 AYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE 652
Query: 995 DLECEIG----EMYVVMKNAGLSGKEMTAKTKLEKEID--------EIRSKLSKNDSEFT 1042
LE ++ + K + +++ K + +D E++ + K D
Sbjct: 653 RLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALK 712
Query: 1043 NEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
+N++ E K++ +++ LE K+ LE Q K +EE+ + ++
Sbjct: 713 ALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELK 772
Query: 1103 KLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKE 1162
+KN SLQ T + D TK+++ +KL +E
Sbjct: 773 -----IKNH-SLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE 826
Query: 1163 VGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRL 1222
+ K+ C+ + ++ +V + L T R++
Sbjct: 827 L---QKQRESSAEKLRKMEEKCESAAHEADLKRQKV--------------IELTGTARQV 869
Query: 1223 SIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSL----------ESTIAAK 1272
IE+ K+EL SK +E E+ LK D ENK L ++ + K
Sbjct: 870 KIEMDQYKEEL--------SK---MEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKK 918
Query: 1273 DVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ-----DELNNAKIK 1327
+K+LE L+ +T + EA E++E Q D L A++
Sbjct: 919 TNAVKELE-KLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLS 977
Query: 1328 LEK-------TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKEL 1380
LE+ AE K+E+ K +L +++ ++ + +E
Sbjct: 978 LEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREH 1037
Query: 1381 DTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSG-------AGAKRITEL 1433
+++ + KL+ + ++K + ++ +L KL+ ++ + I++L
Sbjct: 1038 RGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQL 1097
Query: 1434 KQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQ-AQGELLHVQK 1492
K+E E T ++++ ++ K + + + +Y+ E + + RLT E+ Q + EL +
Sbjct: 1098 KKEIERTQQRMKEMESVMKEQEQYIATQYK--EAIDLGQELRLTREQVQNSHTELAEARH 1155
Query: 1493 ELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
+ A EI+ L +L + + EK N +A E L G +V A L AR+
Sbjct: 1156 QQVQAQREIERLSSEL-EDMKQLSKEKDAHGNHLA---EEL--GASKVREAHLEARMQAE 1209
Query: 1553 ERELRA 1558
++L A
Sbjct: 1210 IKKLSA 1215
Score = 40.3 bits (90), Expect = 0.069
Identities = 111/727 (15%), Positives = 257/727 (35%), Gaps = 20/727 (2%)
Query: 1078 NENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXX 1137
N + +S Q K L E +N+ Q K+ ++ SLQ + +C+
Sbjct: 177 NLEAEVSAQDKVL-REAENKLEQSQKMV--IEKEQSLQESKEECIKLKVDLLEQTKQGKR 233
Query: 1138 XXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDR 1197
+ N ++ + + K+V +K +K+ C++ K+L R
Sbjct: 234 AERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGL 293
Query: 1198 VTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKAD 1257
Q N + + + E+ A+ ++ + LE+E+ +
Sbjct: 294 YKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEI 353
Query: 1258 YENKITSLESTIAAKDVHIKQLE--DALRQTTNDKYDEATSPVEMV-EMRXXXXXXXXXX 1314
+K + + K Q E D +Q E S +++ ++
Sbjct: 354 LRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKS 413
Query: 1315 XXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWE 1374
+ ++++ K ++ A KL +++L+ LA E S
Sbjct: 414 YLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLIT 473
Query: 1375 NKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK 1434
+ + L S + + +++ + KD T+ + + Q G + +
Sbjct: 474 CNDSQESSKLSS--LETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKL 531
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
+ E L+ ++A ++++ + + ELLE+ +K + K+ +Q LL ++K+L
Sbjct: 532 IQIEAENSDLKVNMAHRTSQFQLI--QEELLEKASNSSKLESEMTKKCSQ--LLTLEKQL 587
Query: 1495 S---TALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL--NARL 1549
A I +L E N + ++ +I + E++C + ++ L + +
Sbjct: 588 EEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEM 647
Query: 1550 DQRERELRAANDRRDV-LEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXX 1608
+++ L A +++D + E + ++
Sbjct: 648 EKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKK 707
Query: 1609 XXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAA 1668
++ ++ + E + L L +F ++ + +
Sbjct: 708 DEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCL 767
Query: 1669 QKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
QK + +IKN +N I ++ + + + LED + SKL E
Sbjct: 768 QKEL-KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE 826
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRA-RVAGLATRMELAWHKERDEQQRLLQE 1787
L ++ S+ +L +M+ + E L + + G A ++++ + ++E ++ +E
Sbjct: 827 LQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKE 886
Query: 1788 TSTLARD 1794
L RD
Sbjct: 887 IMHLKRD 893
>AK128577-1|BAC87508.1| 1080|Homo sapiens protein ( Homo sapiens cDNA
FLJ46736 fis, clone TRACH3020769, weakly similar to
Myosin heavy chain, nonmuscle type B. ).
Length = 1080
Score = 68.5 bits (160), Expect = 2e-10
Identities = 172/855 (20%), Positives = 346/855 (40%), Gaps = 84/855 (9%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKE-KSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
N + D ++ L Q + + CE K+ +LL ++ + S +LK+Q
Sbjct: 233 NQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKD------SVSLLKIQ 286
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIE-QLRAKLLAAET-LC 381
E ++ + LT KI+++E ++ ++T++I+ QL + + E LC
Sbjct: 287 DAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELC 346
Query: 382 EELMDEN-EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
N E+ K+ D Q +E+Q + ++++LE +++ L +L+
Sbjct: 347 SLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQT---LEMELRT 403
Query: 441 TERKADQLEQEKAEHEKKLLEIVGG---PDGMQRENRIKELEQEVARSTEVALRLQRELA 497
+ +Q+ QE+ + +++L DG+ + K+ E E+A+ + + +
Sbjct: 404 VKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKK---MNSENSHS 460
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLT--RGGSQEDPAQLLRDLQDSLEREADLREQ 555
K S+++ E + + R + + +QE + DL+ E+ DL++
Sbjct: 461 HEEEKDLSHKNSMLQ----EEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKT 516
Query: 556 LRNAEEE-TANCKQVNP--PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++ EE T Q N + M ++ + + E + +++ A+
Sbjct: 517 IKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD 576
Query: 613 KEKSDSPP----LSIDKTTEET-----QFHFDLPYLSIFNHMAANNLRKTAARVEEDNES 663
+++S++ L+ + +E + +FD+ L N + + L KT +++ S
Sbjct: 577 RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLN----S 632
Query: 664 LLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATV 723
L ++ R + L LS +T E E + ++K+ + +QE+
Sbjct: 633 LEIEFHHTRDALREKTLGLERVQKDLS-QTQCQMKEME-QKYQNEQVKVNKYIGKQES-- 688
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR---RSLTTNSNK---LAEE 777
+ ++ +L+ + L++Q+ + +K + KT + L S K L EE
Sbjct: 689 VEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEE 748
Query: 778 RVKVLEDEIDEVRKKLIEKERD-CERLHAELSLAQKKPKTLIKSR----SLDASDQQNVD 832
R K L E + ++++ + E + ER L Q+ TL K SL+ + + ++
Sbjct: 749 RNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRIN 808
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADN-------EKLQTENKKLQL----LKNAKSLRSDK 881
L+ + Q ++++ +R + Q + + EK+Q +KL+ LK + DK
Sbjct: 809 LEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTIKKQMDK 868
Query: 882 ALDLNTKK-TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXX 940
+L L + KE L K+ EL+ + ++ + E ++E K+
Sbjct: 869 IEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLGQEMKKNVEL-EREITGFKNLLKMT 927
Query: 941 XXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTK----LQLKKMVEDL 996
T + D K +I +L T L L + L
Sbjct: 928 RKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQIL 987
Query: 997 ECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK-------NRLQ 1049
+ E+ M V K K K KLE+E+ +RS + +N E K R +
Sbjct: 988 QEELLSMKTVQKKCEKLQKN---KKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERAR 1044
Query: 1050 TEIA-KLKDVNAKLE 1063
EIA KLK+VN L+
Sbjct: 1045 QEIAEKLKEVNLFLQ 1059
Score = 64.9 bits (151), Expect = 3e-09
Identities = 188/910 (20%), Positives = 365/910 (40%), Gaps = 78/910 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANI-DTANKYTTGRSSEVLKLQQKVNELT 330
+ + L++E L+K E K+ + + ANI D A + +Q++ + T
Sbjct: 88 EFQALEKEKVQLQKEVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGET 147
Query: 331 THNEDLRDEKKHLTQ-----KIREIES-ELETRPSTEAQTRQI----EQLRAKLLAAE-- 378
H + R E K +++E++S E E R S E+ + L LL +
Sbjct: 148 DHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDD 207
Query: 379 -TLCEELMDENEDMKK---ELRDLXXXXXXMQDNFREDQADEYSSLRREL-EQTIKNCRV 433
+L E DE KK E + M D Q+ E +S EL + KN +
Sbjct: 208 SSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFML 267
Query: 434 LSFKLKKTERKADQLE--QEKAEHEKKLLEIVGGPDGM------QRENRIKELEQEVARS 485
L +L + + L Q+ A ++LLE+ + + E+++ L++E++ +
Sbjct: 268 LIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSET 327
Query: 486 TEVALRLQRELAEANSKFTGSNPSLMKVPQP----ETV-KVSRSSLTRGGSQ-EDPAQLL 539
E+ +L+ + E + SL + + +T+ + R L R Q ++
Sbjct: 328 KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVK 387
Query: 540 RDLQDSLER-EADLREQLRNAEE--ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
+ L+ SL+ E +LR N + + N Q + +++ D I+T + + + +
Sbjct: 388 QQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI- 446
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAAR 656
+ K +++ ++ S +E+ D + E ++ + N +
Sbjct: 447 -EMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKI 505
Query: 657 VEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL 716
V+E NE L +K+ + L+ E A N + E ++ ++ +E
Sbjct: 506 VKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 565
Query: 717 NEQEATVLRRKVEELEQDKEALK---KQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
++ E K L+ ++ ++ S++ SN + +
Sbjct: 566 YHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDV-SNLKDNNEILSQQLF 624
Query: 774 LAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDL 833
E ++ LE E R L EK ER+ +LS Q + K + + + + + N +
Sbjct: 625 KTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEM-EQKYQNEQVKVNKYI 683
Query: 834 KRQLQVIEQEASVLRAKTQSL--EADNEKLQTENKKLQLLKNAKSLRS--DKALDLNTKK 889
+Q + +E+ S L+++ L + D+ + +NK+ ++ + K + K+
Sbjct: 684 GKQ-ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQ 742
Query: 890 TTQLENELKEALAK---IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
+ LE KE +++ +KE + ++EK+E++V + ++ DTLK +
Sbjct: 743 SLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVT 802
Query: 947 XXXXXXXXXXXQATLKSL------KDDAQKSFKP--RIPKKPTDLTTKLQ-----LKKMV 993
Q K L +AQ R +K D KL+ LK +
Sbjct: 803 SRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTI 862
Query: 994 EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIA 1053
+ +I E+ + NA LS E K +L K++ E++ L N + + L+ EI
Sbjct: 863 KKQMDKIEELQKNLLNANLSEDE---KEQL-KKLMELKQSLECNLGQEMKKNVELEREIT 918
Query: 1054 KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
K++ K+ K N+Y EN + KT EM + QINKL + + T+
Sbjct: 919 GFKNL-LKMTRKK---LNEY---ENGEFSFHGDLKTSQFEM---DIQINKLKHKIDDLTA 968
Query: 1114 -LQTTMSDCM 1122
L+T S C+
Sbjct: 969 ELETAGSKCL 978
Score = 55.6 bits (128), Expect = 2e-06
Identities = 167/892 (18%), Positives = 343/892 (38%), Gaps = 87/892 (9%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
KEY L+ + ++ +R KE + + A++ T S + ++ +
Sbjct: 158 KEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDE 217
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
T + +++ K+ Q + +++ + S+E + E + L E+L
Sbjct: 218 GRPTKKTSNEKNKVKNQIQSMDDVD---DLTQSSETASEDCELPHSSYKNFMLLIEQLGM 274
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
E +D L+ + E + + L ++++ VL +L +T+
Sbjct: 275 ECKDSVSLLK--IQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS 332
Query: 447 QLEQEKAEHEKKL--LEIVGGPDGMQREN----------RIKELEQEVARSTEVALRLQR 494
QLE +K E E++L L + +R N +++ E++ + EV +L+
Sbjct: 333 QLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLEL 392
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD--LQDSLEREADL 552
L + +L +V Q R+ R S+E A++L+D L + L ++ ++
Sbjct: 393 SLQTLEMELRTVKSNLNQVVQ------ERNDAQRQLSREQNARMLQDGILTNHLSKQKEI 446
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHA-ASTPS 611
+ E ++ + ++ + I + E +T+ N Q K
Sbjct: 447 EMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRL-EIDTIKNQNQEKEKKCFEDLKI 505
Query: 612 SKEKSDSPPLSIDKTTEET------QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLL 665
KEK++ +I K EET Q++ L L+ N M + L E +
Sbjct: 506 VKEKNEDLQKTI-KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVE 564
Query: 666 LQLKKMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEA--DPAEMKLLLELNEQEAT 722
++A R S T +L+ + A D + D+ D + +K E+ Q+
Sbjct: 565 SYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLF 624
Query: 723 VLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVL 782
K+ LE + + ++E T + V K + + + N+ + +
Sbjct: 625 KTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIG 684
Query: 783 EDEIDEVRKKLIEKERDC--ERLHAELSLAQKKPKTLIKSRS--------LDA-SDQQNV 831
+ E E R ++ E ++L + A K KT+I + L A S++Q++
Sbjct: 685 KQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSL 744
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA-----KSLRSDKALDLN 886
L+ + + + E + L K + + +NEK + E QL + K S+ +L++
Sbjct: 745 LLEERNKELISECNHL--KERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVT 802
Query: 887 TKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
++ LE+E ++ K+ ++ +++ E + R TEA + KQ
Sbjct: 803 SRYRINLEDETQDLKKKLGQI----RNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKL 858
Query: 947 XXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE---DLECEIGEM 1003
+ T+K D ++ K + ++ K QLKK++E LEC +G+
Sbjct: 859 -----------KVTIKKQMDKIEELQKNLLNANLSE-DEKEQLKKLMELKQSLECNLGQ- 905
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
EM +LE+EI ++ L + +N + LK +++
Sbjct: 906 ------------EMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMD 953
Query: 1064 GDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+ +K L E ++C L + + + ++ + K LQ
Sbjct: 954 IQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQ 1005
Score = 53.6 bits (123), Expect = 7e-06
Identities = 102/509 (20%), Positives = 200/509 (39%), Gaps = 52/509 (10%)
Query: 1259 ENKITSLESTIAAKDVHIKQLE-DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXX-- 1315
E K S ++++ +++ + +LE D ++ +K + +++V+ +
Sbjct: 463 EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEE 522
Query: 1316 XXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
++ +L AE++ ++ K +LE E
Sbjct: 523 TLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSET 582
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+EL+ Q R + R++ + DV N LK +IL Q ++ L+
Sbjct: 583 SKRELELAFQRARDECSRLQDKMNFDVSN-------LKDNNEILSQQLFKTESKLNSLEI 635
Query: 1436 EYEETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
E+ T L E +L LE+ + + + ++ E E ++ V K + E V++ L
Sbjct: 636 EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQE--SVEERL 693
Query: 1495 STALGEIKTLQEKLG-TESAAWNTEKT--EMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
S E L+++L + A N EKT +Q+ ++ ++L + E + + L++
Sbjct: 694 SQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKL-----QAESEKQSLLLEE 748
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
R +EL + + ++ ++ ER + R
Sbjct: 749 RNKELISECNHLKERQYQYENEKA------------ER-EVVVRQLQQELADTLKKQSMS 795
Query: 1612 XXXIEQSEKAR---KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEA- 1667
+E + + R + E D K + GQ+ E + H + R + ++KQ LE
Sbjct: 796 EASLEVTSRYRINLEDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKD 854
Query: 1668 -AQKSMAEIKNGDKSARIHRNSIS---STDEEEYRNKVALLEQQVAC-LEDELCESRLLA 1722
A+ + K DK + +N ++ S DE+E K+ L+Q + C L E+
Sbjct: 855 NAKLKVTIKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLGQEM------- 907
Query: 1723 SKLNTELVSEKSSAEVRLAEMQSRLNEYE 1751
K N EL E + + L + +LNEYE
Sbjct: 908 -KKNVELEREITGFKNLLKMTRKKLNEYE 935
Score = 34.7 bits (76), Expect = 3.4
Identities = 45/275 (16%), Positives = 108/275 (39%), Gaps = 15/275 (5%)
Query: 1233 LQARFIKTESKFITLEAEM---RDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTND 1289
L + K E K L+ E+ +++K+ E++ E + + + Q E+ R+ +
Sbjct: 306 LTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQ-EEEKRRNADT 364
Query: 1290 KYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDL 1349
Y++ + E + L +++L ++ + E + L
Sbjct: 365 LYEKIREQLRRKEEQYRKEVEVKQQLELS--LQTLEMELRTVKSNLNQVVQERNDAQRQL 422
Query: 1350 AKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD---LQSERKKLDRMRIAHDKDVKNKD 1406
++ +N E K+++++ E K L +++
Sbjct: 423 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLR 482
Query: 1407 AELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLE 1466
E+ T+K + + E+ K + E ++ ++T+K+ E +L ++Y G+ +L
Sbjct: 483 LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQY---NGRLSVLT 539
Query: 1467 EEHVVTKARLTVE---KEQAQGELLHVQKELSTAL 1498
E+ + ++L E KE+ + E+ L+ A+
Sbjct: 540 AENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI 574
Score = 34.7 bits (76), Expect = 3.4
Identities = 31/131 (23%), Positives = 60/131 (45%), Gaps = 6/131 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+D + + + +I+ L E++ +C ++ K+ IL L ++ T K K
Sbjct: 952 MDIQINKLKHKIDDLTAELETAGSKCLHLDT-KNQILQEELLSMKTVQKKCEKLQKNKKK 1010
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ-LRAKLLAAETL 380
L+Q+V L +H E E + Q +EIE R + +++ L+A+ + E L
Sbjct: 1011 LEQEVINLRSHIERNMVELGQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAASQENL 1068
Query: 381 CEELMDENEDM 391
E + E +D+
Sbjct: 1069 --EQLREKQDL 1077
>AB210007-1|BAE06089.1| 2121|Homo sapiens NUMA1 variant protein
protein.
Length = 2121
Score = 68.5 bits (160), Expect = 2e-10
Identities = 151/785 (19%), Positives = 309/785 (39%), Gaps = 53/785 (6%)
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK-NCRVLS 435
+ T EEL + K+E+R L + + +S ++ QT + R L
Sbjct: 167 SSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLK 226
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEVARSTEVALRLQR 494
+L D+LE E AE+ K L E MQ R +R+ L ++ A S L+
Sbjct: 227 KQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE- 285
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
EL + N T +K Q + +K +S + R +Q DL L A +
Sbjct: 286 ELRDKNESLTMRLHETLK--QCQDLKTEKSQMDRKINQLSEEN--GDLSFKLREFASHLQ 341
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS---IQNKMIHAASTPS 611
QL++A E +L+KQ + ++ + + + + +Q K+ S
Sbjct: 342 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 401
Query: 612 SKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE-DNESLLLQLKK 670
+ D+PP + + L + +AANN + ARVE + E + K
Sbjct: 402 QLQ--DNPPQEKGEVLGDVLQLETLKQEAAT--LAANNTQ-LQARVEMLETERGQQEAKL 456
Query: 671 MATKAR----SRKLSPTPPANKLSIETANDNDEK--ETDEADPAEMKLLLELNEQEATVL 724
+A + ++LS + SI + E+ + +A A + + E T L
Sbjct: 457 LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL 516
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT--TNSNKLAEERVKVL 782
+++ +Q+ LK+Q KE ++++ + ++ R + ++S K E+++K +
Sbjct: 517 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV 576
Query: 783 EDEIDEVRKKLIE-------------KERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
++ + R+ + +ERD E +K K I + L +++
Sbjct: 577 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 636
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQ--LLKNAKSLRSDKALDLNT 887
+ + ++E + L K + L+A E + E + Q + + LRS++
Sbjct: 637 RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 696
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++ Q +++L+E L +KE + + E+K R +A +++ + +
Sbjct: 697 ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH 756
Query: 948 XXXXXXXXXXQATLKSLKDDAQ---KSFKPRIPKKPTDLTTKLQLKKMVEDLECE--IGE 1002
+A K L+ Q ++ + +L + + E ECE + E
Sbjct: 757 KRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES-ECEQLVKE 815
Query: 1003 MYVVMKNAGLSGKE--------MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
+ + S +E L++E ++ R +L + + ++ + +I++
Sbjct: 816 VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR 875
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSL 1114
++ A+L + + + E L++ TL E+M ++ +L ++ A
Sbjct: 876 QQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQ 935
Query: 1115 QTTMS 1119
Q T S
Sbjct: 936 QETAS 940
Score = 68.5 bits (160), Expect = 2e-10
Identities = 161/842 (19%), Positives = 334/842 (39%), Gaps = 90/842 (10%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
L ++E +D+ E L + K+C+ ++ EKS + R++ + S E
Sbjct: 279 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ-MDRKINQL----------SEENG 327
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
L K+ E +H + L+D LT+ E T+ E Q + ++L A L +
Sbjct: 328 DLSFKLREFASHLQQLQDALNELTE-----EHSKATQEWLEKQAQLEKELSAAL--QDKK 380
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
C L ++NE ++ +L L +QDN +++ + + +LE + L+ +
Sbjct: 381 C--LEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV-LQLETLKQEAATLAANNTQ 437
Query: 441 TERKADQLEQEKAEHEKKLLEIVG--GPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ + + LE E+ + E KLL G + Q + I +L+ ++ ++ L++
Sbjct: 438 LQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQA 497
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
++ T SL + + G ++ + L +L+++ + LR+
Sbjct: 498 HGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRH 557
Query: 559 -AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E+ +++ KQ K+V T H + T A +S + D
Sbjct: 558 QVEQLSSSLKQKEQQL---KEVAEKQEATRQDHAQQLAT--------AAEEREASLRERD 606
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
+ ++ +E ++ + AN R +A ++ + Q ++ + S
Sbjct: 607 AALKQLEALEKEKAAKLEILQQQL---QVANEARDSA-------QTSVTQAQREKAEL-S 655
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE---LEQD 734
RK+ + +ETA E+ +A AE++L L +Q+AT R +E L++
Sbjct: 656 RKVEEL----QACVETA--RQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 709
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
+ALK+ +K + + +A + +R + ++L E ++E E RK+L
Sbjct: 710 LQALKESLKVTKGSLEEEKRRAADALEEQQRCI----SELKAETRSLVEQHKRE-RKELE 764
Query: 795 EKERDCERLHAEL-SLAQ-KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAK-- 850
E+ + L A L L + + +T + R L + + + + + +E + R +
Sbjct: 765 EERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYE 824
Query: 851 -TQSLEAD-----NEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
+Q EA E+L T ++ + + +K + + Q+ + E LA++
Sbjct: 825 DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNE-LAEL 883
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
+ EK+VR + + TL+ K TL
Sbjct: 884 HANLARALQQVQEKEVR-AQKLADDLSTLQEKMAATSKEVARL-----------ETLVRK 931
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE 1024
+ Q++ + K+P + E LE + G + A L E A+ ++
Sbjct: 932 AGEQQETASRELVKEPARAG-----DRQPEWLEEQQGRQF-CSTQAALQAMEREAE-QMG 984
Query: 1025 KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
E++ +R+ L ++ + E+ + + E+A+L + + D + LE N
Sbjct: 985 NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1044
Query: 1085 NQ 1086
N+
Sbjct: 1045 NE 1046
Score = 67.3 bits (157), Expect = 5e-10
Identities = 132/659 (20%), Positives = 271/659 (41%), Gaps = 63/659 (9%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEV-LKLQQKVNELT 330
++E L+Q V L+++ + EKE A+ A GR+ KL+ E++
Sbjct: 1085 ELEELRQTVKQLKEQLAKKEKEH--------ASGSGAQSEAAGRTEPTGPKLEALRAEVS 1136
Query: 331 THNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENED 390
+ + +++ R +E+E +R ++ +E L+ +L E +EL
Sbjct: 1137 KLEQQCQKQQEQADSLERSLEAERASRAERDSA---LETLQGQL---EEKAQELGHSQSA 1190
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
+ R+L +QD+ + + + R E KN + S + + + LE+
Sbjct: 1191 LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEK 1250
Query: 451 EKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
E E K L + + E R++ L+ E A ++ A AE +S SL
Sbjct: 1251 EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA-------AERSSALREEVQSL 1303
Query: 511 MKVPQPETVKVS--RSSLTRGGSQ-EDPAQLLRDLQDSLEREADLREQLRNAEEET-ANC 566
+ + + V R LT + E+ Q L+ Q+ ++ L+ T A
Sbjct: 1304 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1363
Query: 567 KQVNPPTFLDKQVMTDNIVT-----CDIHESETVTNSIQNKMIHAAS-----TPSSKEKS 616
++ P L +Q+ + ++ +S+ ++ +++ A P ++ +
Sbjct: 1364 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVA 1423
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
+ + E+ + L L + + A R R + L ++L + K
Sbjct: 1424 EQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYV 1483
Query: 677 SRKLSPTPPANKLSIETANDND------EKETDEADPAEMKLLLELN--EQEATVLRRKV 728
+ A E + E T + + A++K+L E ++E L +V
Sbjct: 1484 QELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV 1543
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE 788
E+LE + KQV+EL+ K++ + S + +++ + L+ +++E
Sbjct: 1544 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE--SQQEAQRLQAQLNE 1601
Query: 789 VRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR 848
++ +L +KE+ E H +L + +K KT DA QQN +L+ QL+ +EQ L+
Sbjct: 1602 LQAQLSQKEQAAE--HYKLQM--EKAKT-----HYDAKKQQNQELQEQLRSLEQ----LQ 1648
Query: 849 AKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
+ + L A+ E+L E ++ L K+ +++ T + LE ++ A ++++L
Sbjct: 1649 KENKELRAEAERLGHELQQAGL----KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1703
Score = 62.1 bits (144), Expect = 2e-08
Identities = 139/691 (20%), Positives = 285/691 (41%), Gaps = 59/691 (8%)
Query: 271 DQIEGLKQEVDILRKRCERVEKEKS---DILLRRL--AN--IDTANKYTTGRSSEVLKLQ 323
++ E +E D K+ E +EKEK+ +IL ++L AN D+A T E +L
Sbjct: 596 EEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 655
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESEL--ETRPSTEAQ--TRQIEQLRAKLLAAET 379
+KV EL E R E+ ++ E+E +L E + +TE + ++ +QL+ +L A +
Sbjct: 656 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKE 715
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ---ADEYSSLRRELEQTIKNCRVLSF 436
+ E+ K+ D + + +++ R+ELE+ + L
Sbjct: 716 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 775
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+L++ +A Q E E E L E + E+ ++L +EVA E Q+E
Sbjct: 776 RLQQL-GEAHQAETEVLRRE--LAEAMAAQH--TAESECEQLVKEVAAWRERYEDSQQEE 830
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRS-SLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
A+ + F +L + + ++ + G Q+ R + E A+L
Sbjct: 831 AQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARA 890
Query: 556 LRNAEEETANCKQV--NPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
L+ +E+ +++ + T +K T ++ ET+ + +S+
Sbjct: 891 LQQVQEKEVRAQKLADDLSTLQEKMAATSK----EVARLETLVRKAGEQ-----QETASR 941
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMAT 673
E P + D+ E + + S A + + A ++ + E L L +
Sbjct: 942 ELVKEPARAGDRQPEWLEEQQGRQFCS--TQAALQAMEREAEQMGNELERLRAALMESQG 999
Query: 674 KARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLE--LNEQE---ATV---LR 725
+ + + +L+ E + ++A AE+++ L+ LNEQ AT+ L
Sbjct: 1000 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1059
Query: 726 RKVEELE-QDKEALK------KQVKELTSKISSVTKTSAG-SNTTARRSLTTNSNKLAEE 777
+ E E +D+E K Q+KEL +V + + + + + A
Sbjct: 1060 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1119
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV--DLKR 835
R + +++ +R ++ + E+ C++ + ++ + SR+ S + + L+
Sbjct: 1120 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 1179
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENK-----KLQLLKNAKSL-RSDKALDLNTKK 889
+ Q + S L + + L A K+Q +K K Q+ + + R + + ++
Sbjct: 1180 KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE 1239
Query: 890 TTQLENELKEALAKIKELE--MICQDEKSEK 918
+ L ++ E + KEL+ ++ + EKS+K
Sbjct: 1240 VSILNRQVLEKEGESKELKRLVMAESEKSQK 1270
Score = 58.8 bits (136), Expect = 2e-07
Identities = 191/1109 (17%), Positives = 422/1109 (38%), Gaps = 87/1109 (7%)
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSN 760
E A P E K L EL ++ ++ R E L+Q ++ LK + ++ KI+ +++ + G
Sbjct: 272 EKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD-LKTEKSQMDRKINQLSEEN-GDL 329
Query: 761 TTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKS 820
+ R ++ +L ++ + L +E + ++ +EK+ E+ ELS A + K L
Sbjct: 330 SFKLREFASHLQQL-QDALNELTEEHSKATQEWLEKQAQLEK---ELSAALQDKKCL--- 382
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD 880
+++N L+ +L +E+ S L+ + ++ + +L+ LK + +
Sbjct: 383 ------EEKNEILQGKLSQLEEHLSQLQDNPPQ---EKGEVLGDVLQLETLKQEAATLAA 433
Query: 881 KALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXX 940
L + LE E + AK+ ++EK + T+ ++ ++K+
Sbjct: 434 NNTQLQAR-VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE 492
Query: 941 XXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEI 1000
+ L +L Q+ + K + QL + ++ E
Sbjct: 493 QASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE--- 549
Query: 1001 GEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA 1060
+ GL + + L+++ +++ K ++ + +L T A+ ++ +
Sbjct: 550 ------QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA-AEEREASL 602
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
+ ++D + +ALE E + + + L ++++ + + A + +S
Sbjct: 603 R---ERDAALKQLEALEKEKAA---KLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 656
Query: 1121 CMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXX 1180
+ +++ + +Q K + V + ++ +
Sbjct: 657 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKES 716
Query: 1181 XXXCK-RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK 1239
K +E++ D + + L H+R EL E+ + +
Sbjct: 717 LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEAR 776
Query: 1240 TESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVE 1299
+ +AE L+ + + + + + + +K++ A R+ D E
Sbjct: 777 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGA 835
Query: 1300 MVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXX 1359
M + + + EL AK K+ E+ S +L++++ +++LA+L
Sbjct: 836 MFQEQLMTLKEECEKA--RQELQEAKEKVAGIESHS---ELQISRQQNELAELHANLARA 890
Query: 1360 XXXXXXXXXXSSYWENKAKELDTDLQSERKKL--DRMRIAHDKDVKNKDAELATLKGKLK 1417
E +A++L DL + ++K+ +A + + K E + +
Sbjct: 891 LQQVQEK-------EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASR-E 942
Query: 1418 ILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLT 1477
++++ + AG ++ L+++ + +L + E E++ + E L + ++ +
Sbjct: 943 LVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 1002
Query: 1478 VEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGG- 1536
E+ Q + E+ + +E A ++ + E + A+LQE L
Sbjct: 1003 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1062
Query: 1537 ----GWEVERARLNA-------RLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXX 1585
G + E A+L L++ + ++ ++ E H
Sbjct: 1063 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE 1122
Query: 1586 DYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQS---EKARKAEITDTKTRYEGQMNTMRD 1642
+ R +E+S E+A +AE +GQ+
Sbjct: 1123 PTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQ 1182
Query: 1643 ELKSLHNQVSRFRRE----RDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
EL + ++ +RE R + +A + A++ G + A +NS+ S+ EEE
Sbjct: 1183 ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE-RKNSLISSLEEE-- 1239
Query: 1699 NKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
V++L +QV LE E ES+ L + E SEKS +++ RL + E +S
Sbjct: 1240 --VSILNRQV--LEKE-GESKELKRLVMAE--SEKSQ------KLEERLRLLQAETASNS 1286
Query: 1759 GRARVAGLATRMELAWHKERDEQQRLLQE 1787
RA A R E+ +E E+QR+ E
Sbjct: 1287 ARAAERSSALREEVQSLREEAEKQRVASE 1315
Score = 58.4 bits (135), Expect = 2e-07
Identities = 122/633 (19%), Positives = 265/633 (41%), Gaps = 63/633 (9%)
Query: 310 KYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIE 368
K T + +++ +QQ+++ L NE +++ E+ + E+ +T +Q +
Sbjct: 248 KLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE-PKELEELRDKNESLTMRLHETLKQCQ 306
Query: 369 QLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE-LEQT 427
L+ + + +L +EN D+ +LR+ +QD E +E+S +E LE+
Sbjct: 307 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNE-LTEEHSKATQEWLEKQ 365
Query: 428 IKNCRVLSFKL---KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
+ + LS L K E K + L+ + ++ E+ L ++ P + E L+ E +
Sbjct: 366 AQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLK 425
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ---LLRD 541
L AN+ + +++ + + + ++ RG +E+ Q L+ D
Sbjct: 426 QEAATL-------AANNTQLQARVEMLETERGQ--QEAKLLAERGHFEEEKQQLSSLITD 476
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
LQ S+ + +E+L A + + L ++ T N T + E
Sbjct: 477 LQSSISNLSQAKEELEQA-SQAHGARLTAQVASLTSELTTLN-ATIQQQDQEL------- 527
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQ-FHFDLPYLSIFNHMAANNLRKTAARVEED 660
A +KEK ++ + + +Q + LS L++ A + E
Sbjct: 528 ----AGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 583
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ +++AT A R+ S L A + ++ E ++++ E +
Sbjct: 584 RQD---HAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA 640
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
T V + +++K L ++V+EL + + TAR+ ++AE ++
Sbjct: 641 QT----SVTQAQREKAELSRKVEELQACVE-----------TARQEQHEAQAQVAELELQ 685
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD-LKRQLQV 839
+ ++ K+ + +E+D +L +L ++ K + SL+ ++ D L+ Q +
Sbjct: 686 LRSEQQKATEKERVAQEKD--QLQEQLQALKESLK--VTKGSLEEEKRRAADALEEQQRC 741
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
I S L+A+T+SL +++ + E ++ + + R + + + +T L EL E
Sbjct: 742 I----SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAE 797
Query: 900 ALAKIKELEMICQD---EKSEKKVRFTEATKKE 929
A+A E C+ E + + R+ ++ ++E
Sbjct: 798 AMAAQHTAESECEQLVKEVAAWRERYEDSQQEE 830
Score = 55.6 bits (128), Expect = 2e-06
Identities = 102/579 (17%), Positives = 220/579 (37%), Gaps = 40/579 (6%)
Query: 1225 ELTSEKDELQARFIKTESKFIT-LEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDAL 1283
ELT E + +++ +++ L A ++D K E K L+ ++ + H+ QL+D
Sbjct: 349 ELTEEHSKATQEWLEKQAQLEKELSAALQDKKC-LEEKNEILQGKLSQLEEHLSQLQDNP 407
Query: 1284 RQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL--E 1341
Q +K + +++ ++ Q A++++ +TE AKL E
Sbjct: 408 PQ---EKGEVLGDVLQLETLKQEAATLAANNTQLQ-----ARVEMLETERGQQEAKLLAE 459
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+ + +L + E ++ L ++ L +
Sbjct: 460 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 519
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
++ +D ELA LK + K + ++ + Q V++L SL ++ + +E+ K
Sbjct: 520 IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK 579
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
E ++H A E+E + E K+L E E L + N +
Sbjct: 580 QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 639
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
Q S+ Q E+A L+ ++++ + + A + +
Sbjct: 640 AQTSVTQAQR---------EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 690
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
+ ERV++ + +E+ EK R A+ + + R ++ ++
Sbjct: 691 QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE-EKRRAADALEEQQRC---ISELK 746
Query: 1642 DELKSLHNQVSRFRRERDNY---KQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
E +SL Q R R+E + ++ LEA + + E + + + +
Sbjct: 747 AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAE 806
Query: 1699 NKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
++ L ++VA + +S+ E + + +L ++ + +E L
Sbjct: 807 SECEQLVKEVAAWRERYEDSQ-------QEEAQYGAMFQEQLMTLKEECEKARQE--LQE 857
Query: 1759 GRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+ +VAG+ + EL ++++E L + + LAR L+Q
Sbjct: 858 AKEKVAGIESHSELQISRQQNE---LAELHANLARALQQ 893
Score = 44.8 bits (101), Expect = 0.003
Identities = 99/550 (18%), Positives = 209/550 (38%), Gaps = 28/550 (5%)
Query: 1249 AEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXX 1308
A+ R + + E ++ + KD I ++ + + +A SP+E E+
Sbjct: 230 ADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRD 289
Query: 1309 XXXXXXXXXQDELNNAK-IKLEKTEAESSAAKLEMAQLKSDLA-KLENXXXXXXXXXXXX 1366
+ L + +K EK++ + +L ++ DL+ KL
Sbjct: 290 KNESLTMRLHETLKQCQDLKTEKSQMDRKINQL--SEENGDLSFKLRE---FASHLQQLQ 344
Query: 1367 XXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAG 1426
+ E +K L+ ++ +L++ A +D K + + L+GKL LE++
Sbjct: 345 DALNELTEEHSKATQEWLE-KQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQL 403
Query: 1427 AKRITELKQEYEETVKKLE---HSLALEKAEYEELTGKYELLEEEHVVTKARLTVEK--- 1480
+ K E V +LE A A +L + E+LE E +A+L E+
Sbjct: 404 QDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF 463
Query: 1481 EQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEV 1540
E+ + +L + +L +++ + +E+L S A T S+ S L +
Sbjct: 464 EEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQ 523
Query: 1541 ERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXX 1600
++ + +E++ + A + + +++ ++
Sbjct: 524 DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 583
Query: 1601 XXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDN 1660
E S + R A + + E +L+ L Q+ RD+
Sbjct: 584 RQDHAQQLATAAEEREASLRERDAAL----KQLEALEKEKAAKLEILQQQLQVANEARDS 639
Query: 1661 YKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRL 1720
+ + AQ+ AE+ + + + + ++ E + +VA LE Q+ + + E
Sbjct: 640 AQTSVTQAQREKAELSRKVEELQACVET-ARQEQHEAQAQVAELELQLRSEQQKATEKER 698
Query: 1721 LA---SKLNTELVSEKSSAEV---RLAEMQSRLNE--YEEERLLSSGRARVAGLATRMEL 1772
+A +L +L + K S +V L E + R + E++R +S +A L + +
Sbjct: 699 VAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR 758
Query: 1773 AWHKERDEQQ 1782
KE +E++
Sbjct: 759 E-RKELEEER 767
Score = 42.7 bits (96), Expect = 0.013
Identities = 84/404 (20%), Positives = 155/404 (38%), Gaps = 32/404 (7%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E RK L+ +S E+E SI + +SKE ++ + E+S ++ L+Q +
Sbjct: 1225 EAERKNSLI---SSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAE 1281
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
+ NS + + ++ E L QE+ +++
Sbjct: 1282 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK 1341
Query: 287 CERVEKEKSDILLRRLANIDTANKYTTGRS-SEVLKLQQKVNELTTHNEDLRDEKK---- 341
+ E+ S + L + ++ + + L+ +Q E H E+L K+
Sbjct: 1342 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE-KRHREELEQSKQAAGG 1400
Query: 342 ---HLTQKIREIESELETRPSTEAQTRQIEQLRA-KLLAAETL-----CEELMDENEDMK 392
L + RE+ + R Q R +QLRA K AE L L+ E
Sbjct: 1401 LRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGL 1460
Query: 393 KELRDLXXXXXXMQ-DNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
E +L ++ D RE E +++R + E + + ++ + A +LE
Sbjct: 1461 GERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ------REAQSTARELEVM 1514
Query: 452 KAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLM 511
A++E ++++ Q E ++L +V EV R Q + E SK +
Sbjct: 1515 TAKYEGAKVKVLEERQRFQEER--QKLTAQV-EQLEVFQREQTKQVEELSKKLADSDQAS 1571
Query: 512 KVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
KV Q + V +GG + AQ L+ + L+ + +EQ
Sbjct: 1572 KVQQQKLKAVQ----AQGGESQQEAQRLQAQLNELQAQLSQKEQ 1611
Score = 37.9 bits (84), Expect = 0.37
Identities = 67/319 (21%), Positives = 122/319 (38%), Gaps = 26/319 (8%)
Query: 1233 LQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
LQ + +F TL+ + + E K L + IK+LE+ LRQT +
Sbjct: 1040 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE-LRQTVKQLKE 1098
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK- 1351
+ E + E K++ + E + + Q ++D +
Sbjct: 1099 QLAKK----EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLER 1154
Query: 1352 -LENXXXXXXXXXXXXXXXSSYWENKAKEL---DTDLQSERKKLDRMRIAHDKDVKNKDA 1407
LE E KA+EL + L S +++L R K +D
Sbjct: 1155 SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1214
Query: 1408 ELATL-KGKLKILEQNSGAGA--KRITELKQ---EYEETVKKLEHSLALEKAEYEELTGK 1461
A + +G+ + +NS + + ++ L + E E K+L+ + E + ++L +
Sbjct: 1215 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER 1274
Query: 1462 YELLEEEHVVTKARLTV------EKEQAQGELLHVQKELSTALGEIKTLQ----EKLGTE 1511
LL+ E AR E+ Q+ E Q+ S L + T Q E+LG E
Sbjct: 1275 LRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1334
Query: 1512 SAAWNTEKTEMQNSIASLQ 1530
AW + + + ++++LQ
Sbjct: 1335 LKAWQEKFFQKEQALSTLQ 1353
>Z11584-1|CAA77670.1| 2101|Homo sapiens NuMA protein protein.
Length = 2101
Score = 68.1 bits (159), Expect = 3e-10
Identities = 121/582 (20%), Positives = 238/582 (40%), Gaps = 39/582 (6%)
Query: 377 AETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK-NCRVLS 435
+ T EEL + K+E+R L + + +S ++ QT + R L
Sbjct: 161 SSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLK 220
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQ-RENRIKELEQEVARSTEVALRLQR 494
+L D+LE E AE+ K L E MQ R +R+ L ++ A S L+
Sbjct: 221 KQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE- 279
Query: 495 ELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLRE 554
EL + N T +K Q + +K +S + R +Q DL L A +
Sbjct: 280 ELRDKNESLTMRLHETLK--QCQDLKTEKSQMDRKINQLSEEN--GDLSFKLREFASHLQ 335
Query: 555 QLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS---IQNKMIHAASTPS 611
QL++A E +L+KQ + ++ + + + + +Q K+ S
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 612 SKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE-DNESLLLQLKK 670
+ D+PP + + L + +AANN + ARVE + E + K
Sbjct: 396 QLQ--DNPPQEKGEVLGDVLQLETLKQEAAT--LAANNTQ-LQARVEMLETERGQQEAKL 450
Query: 671 MATKAR----SRKLSPTPPANKLSIETANDNDEK--ETDEADPAEMKLLLELNEQEATVL 724
+A + ++LS + SI + E+ + +A A + + E T L
Sbjct: 451 LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL 510
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT--TNSNKLAEERVKVL 782
+++ +Q+ LK+Q KE ++++ + ++ R + ++S K E+++K +
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV 570
Query: 783 EDEIDEVRKKLIE-------------KERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
++ + R+ + +ERD E +K K I + L +++
Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQ--LLKNAKSLRSDKALDLNT 887
+ + ++E + L K + L+A E + E + Q + + LRS++
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKE 929
++ Q +++L+E L +KE + + E+K R +A +++
Sbjct: 691 ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQ 732
Score = 66.5 bits (155), Expect = 9e-10
Identities = 161/841 (19%), Positives = 330/841 (39%), Gaps = 88/841 (10%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
L ++E +D+ E L + K+C+ ++ EKS + R++ + S E
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ-MDRKINQL----------SEENG 321
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL 380
L K+ E +H + L+D LT+ E T+ E Q + ++L A L +
Sbjct: 322 DLSFKLREFASHLQQLQDALNELTE-----EHSKATQEWLEKQAQLEKELSAAL--QDKK 374
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
C L ++NE ++ +L L +QDN +++ + + +LE + L+ +
Sbjct: 375 C--LEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV-LQLETLKQEAATLAANNTQ 431
Query: 441 TERKADQLEQEKAEHEKKLLEIVG--GPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ + + LE E+ + E KLL G + Q + I +L+ ++ ++ L++
Sbjct: 432 LQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQA 491
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
++ T SL + + G ++ + L +L+++ + LR+
Sbjct: 492 HGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRH 551
Query: 559 -AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
E+ +++ KQ K+V T H + T A +S + D
Sbjct: 552 QVEQLSSSLKQKEQQL---KEVAEKQEATRQDHAQQLAT--------AAEEREASLRERD 600
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
+ ++ +E ++ + AN R +A ++ + Q ++ + S
Sbjct: 601 AALKQLEALEKEKAAKLEILQQQL---QVANEARDSA-------QTSVTQAQREKAEL-S 649
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEE---LEQD 734
RK+ + +ETA E+ +A AE++L L +Q+AT R +E L++
Sbjct: 650 RKVEEL----QACVETA--RQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703
Query: 735 KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
+ALK+ +K + + +A + +R + ++L E ++E E RK+L
Sbjct: 704 LQALKESLKVTKGSLEEEKRRAADALEEQQRCI----SELKAETRSLVEQHKRE-RKELE 758
Query: 795 EKERDCERLHA---ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKT 851
E+ + L A +L A + +++ +A Q+ Q++++ A+
Sbjct: 759 EERAGRKGLEARLLQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRDGYE 818
Query: 852 QSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIK---ELE 908
S + + + ++L LK +K Q E KE +A I+ EL+
Sbjct: 819 DSQQEEAQYGAMFQEQLMTLKE------------ECEKARQELQEAKEKVAGIESHSELQ 866
Query: 909 MICQDEK-SEKKVRFTEATK--KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
+ Q K +E A + +E + K TL
Sbjct: 867 ISRQQNKLAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA 926
Query: 966 DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
+ Q++ + K+P + E LE + G + A L E A+ ++
Sbjct: 927 GEQQETASRELVKEPARAG-----DRQPEWLEEQQGRQF-CSTQAALQAMEREAE-QMGN 979
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
E++ +R+ L ++ + E+ + + E+A+L + + D + LE N N
Sbjct: 980 ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALN 1039
Query: 1086 Q 1086
+
Sbjct: 1040 E 1040
Score = 58.4 bits (135), Expect = 2e-07
Identities = 138/691 (19%), Positives = 283/691 (40%), Gaps = 59/691 (8%)
Query: 271 DQIEGLKQEVDILRKRCERVEKEKS---DILLRRL--AN--IDTANKYTTGRSSEVLKLQ 323
++ E +E D K+ E +EKEK+ +IL ++L AN D+A T E +L
Sbjct: 590 EEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESEL--ETRPSTEAQ--TRQIEQLRAKLLAAET 379
+KV EL E R E+ ++ E+E +L E + +TE + ++ +QL+ +L A +
Sbjct: 650 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKE 709
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ---ADEYSSLRRELEQTIKNCRVLSF 436
+ E+ K+ D + + +++ R+ELE+ + L
Sbjct: 710 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+L + +A Q E E E L E + E+ ++L +EVA + Q+E
Sbjct: 770 RLLQL-GEAHQAETEVLRRE--LAEAMAAQH--TAESECEQLVKEVAAWRDGYEDSQQEE 824
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRS-SLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
A+ + F +L + + ++ + G Q+ R E A+L
Sbjct: 825 AQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNKLAELHANLARA 884
Query: 556 LRNAEEETANCKQV--NPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
L+ +E+ +++ + T +K T ++ ET+ + +S+
Sbjct: 885 LQQVQEKEVRAQKLADDLSTLQEKMAATSK----EVARLETLVRKAGEQ-----QETASR 935
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMAT 673
E P + D+ E + + S A + + A ++ + E L L +
Sbjct: 936 ELVKEPARAGDRQPEWLEEQQGRQFCS--TQAALQAMEREAEQMGNELERLRAALMESQG 993
Query: 674 KARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLE--LNEQE---ATV---LR 725
+ + + +L+ E + ++A AE+++ L+ LNEQ AT+ L
Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053
Query: 726 RKVEELE-QDKEALK------KQVKELTSKISSVTKTSAG-SNTTARRSLTTNSNKLAEE 777
+ E E +D+E K Q+KEL +V + + + + + A
Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV--DLKR 835
R + +++ +R ++ + E+ C++ + ++ + SR+ S + + L+
Sbjct: 1114 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 1173
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENK-----KLQLLKNAKSL-RSDKALDLNTKK 889
+ Q + S L + + L A K+Q +K K Q+ + + R + + ++
Sbjct: 1174 KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE 1233
Query: 890 TTQLENELKEALAKIKELE--MICQDEKSEK 918
+ L ++ E + KEL+ ++ + EKS+K
Sbjct: 1234 VSILNRQVLEKEGESKELKRLVMAESEKSQK 1264
Score = 56.4 bits (130), Expect = 1e-06
Identities = 119/613 (19%), Positives = 255/613 (41%), Gaps = 60/613 (9%)
Query: 310 KYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIE 368
K T + +++ +QQ+++ L NE +++ E+ + E+ +T +Q +
Sbjct: 242 KLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE-PKELEELRDKNESLTMRLHETLKQCQ 300
Query: 369 QLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE-LEQT 427
L+ + + +L +EN D+ +LR+ +QD E +E+S +E LE+
Sbjct: 301 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNE-LTEEHSKATQEWLEKQ 359
Query: 428 IKNCRVLSFKL---KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
+ + LS L K E K + L+ + ++ E+ L ++ P + E L+ E +
Sbjct: 360 AQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLK 419
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ---LLRD 541
L AN+ + +++ + + + ++ RG +E+ Q L+ D
Sbjct: 420 QEAATL-------AANNTQLQARVEMLETERGQ--QEAKLLAERGHFEEEKQQLSSLITD 470
Query: 542 LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQN 601
LQ S+ + +E+L A + + L ++ T N T + E
Sbjct: 471 LQSSISNLSQAKEELEQA-SQAHGARLTAQVASLTSELTTLN-ATIQQQDQEL------- 521
Query: 602 KMIHAASTPSSKEKSDSPPLSIDKTTEETQ-FHFDLPYLSIFNHMAANNLRKTAARVEED 660
A +KEK ++ + + +Q + LS L++ A + E
Sbjct: 522 ----AGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQE 720
+ +++AT A R+ S L A + ++ E ++++ E +
Sbjct: 578 RQD---HAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA 634
Query: 721 ATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK 780
T V + +++K L ++V+EL + + TAR+ ++AE ++
Sbjct: 635 QT----SVTQAQREKAELSRKVEELQACVE-----------TARQEQHEAQAQVAELELQ 679
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD-LKRQLQV 839
+ ++ K+ + +E+D +L +L ++ K + SL+ ++ D L+ Q +
Sbjct: 680 LRSEQQKATEKERVAQEKD--QLQEQLQALKESLK--VTKGSLEEEKRRAADALEEQQRC 735
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
I S L+A+T+SL +++ + E ++ + + R + + + +T L EL E
Sbjct: 736 I----SELKAETRSLVEQHKRERKELEEERAGRKGLEARLLQLGEAHQAETEVLRRELAE 791
Query: 900 ALAKIKELEMICQ 912
A+A E C+
Sbjct: 792 AMAAQHTAESECE 804
Score = 55.2 bits (127), Expect = 2e-06
Identities = 103/579 (17%), Positives = 218/579 (37%), Gaps = 40/579 (6%)
Query: 1225 ELTSEKDELQARFIKTESKFIT-LEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDAL 1283
ELT E + +++ +++ L A ++D K E K L+ ++ + H+ QL+D
Sbjct: 343 ELTEEHSKATQEWLEKQAQLEKELSAALQDKKC-LEEKNEILQGKLSQLEEHLSQLQDNP 401
Query: 1284 RQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKL--E 1341
Q +K + +++ ++ Q A++++ +TE AKL E
Sbjct: 402 PQ---EKGEVLGDVLQLETLKQEAATLAANNTQLQ-----ARVEMLETERGQQEAKLLAE 453
Query: 1342 MAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKD 1401
+ + +L + E ++ L ++ L +
Sbjct: 454 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
Query: 1402 VKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGK 1461
++ +D ELA LK + K + ++ + Q V++L SL ++ + +E+ K
Sbjct: 514 IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK 573
Query: 1462 YELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTE 1521
E ++H A E+E + E K+L E E L + N +
Sbjct: 574 QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633
Query: 1522 MQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXX 1581
Q S+ Q E+A L+ ++++ + + A + +
Sbjct: 634 AQTSVTQAQR---------EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
+ ERV++ + +E+ EK R A+ + + R ++ ++
Sbjct: 685 QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE-EKRRAADALEEQQRC---ISELK 740
Query: 1642 DELKSLHNQVSRFRRERDNY---KQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
E +SL Q R R+E + ++ LEA + E + + + +
Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLEARLLQLGEAHQAETEVLRRELAEAMAAQHTAE 800
Query: 1699 NKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
++ L ++VA D +S+ E + + +L ++ + +E L
Sbjct: 801 SECEQLVKEVAAWRDGYEDSQ-------QEEAQYGAMFQEQLMTLKEECEKARQE--LQE 851
Query: 1759 GRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+ +VAG+ + EL + +Q +L + + LAR L+Q
Sbjct: 852 AKEKVAGIESHSELQISR---QQNKLAELHANLARALQQ 887
Score = 47.6 bits (108), Expect = 5e-04
Identities = 199/1149 (17%), Positives = 430/1149 (37%), Gaps = 91/1149 (7%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKE----LTSKISSVTKTSAGSNTTARRSLT 768
+L+ + + L++++ + +++ L+ ++ E LT K + + + A +
Sbjct: 208 ILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEK 267
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
++ L + ++ L D+ + + +L E + C+ L E S +K L +
Sbjct: 268 QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQL---------SE 318
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQ-LLKNAKSLRSDKALDLNT 887
+N DL +L+ + AS L+ Q +A NE + +K Q L+ L + + L
Sbjct: 319 ENGDLSFKLR---EFASHLQ---QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQD 372
Query: 888 KKTTQLENELKEA-LAKIKE-LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXX 945
KK + +NE+ + L++++E L + + EK + + ET ++
Sbjct: 373 KKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQL 432
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTTKLQ-LKKMVEDLE--CEIG 1001
Q K L + + K ++ TDL + + L + E+LE +
Sbjct: 433 QARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH 492
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEI----------RSKLSKNDSEFTNEKNRLQTE 1051
+ + A L+ + T ++++ E+ +++L++ + L+ +
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSN-LSNQCKTLTEEMKNREAQINKLSADLKN 1110
+ +L + E A K +A +++ L+ + ++ R+A + +L A K
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 1111 ATS----LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKI----DQDKNKLLKE 1162
+ LQ + +V+ Q++++ +
Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
Query: 1163 VGDKTKKIGDXXXXXXXXXXXCK---RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTH 1219
V + ++ + ++++QL K+ + +A
Sbjct: 673 VAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQ 732
Query: 1220 RRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSL-ESTIAAKDVHIKQ 1278
+R EL +E L + K E K LE E K E ++ L E+ A +V ++
Sbjct: 733 QRCISELKAETRSLVEQH-KRERK--ELEEERAGRKG-LEARLLQLGEAHQAETEVLRRE 788
Query: 1279 LEDAL--RQTTNDKYDEATSPVEMVE--MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAE 1334
L +A+ + T + ++ V Q++L K + EK E
Sbjct: 789 LAEAMAAQHTAESECEQLVKEVAAWRDGYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
Query: 1335 SSAAKLEMAQLKS----DLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
AK ++A ++S +++ +N E +A++L DL + ++K
Sbjct: 849 LQEAKEKVAGIESHSELQISRQQNKLAELHANLARALQQVQEKEVRAQKLADDLSTLQEK 908
Query: 1391 L--DRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
+ +A + + K E + +++++ + AG ++ L+++ + +L
Sbjct: 909 MAATSKEVARLETLVRKAGEQQETASR-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAAL 967
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ E E++ + E L + ++ + E+ Q + E+ + +E A ++ +
Sbjct: 968 QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
Query: 1509 GTESAAWNTEKTEMQNSIASLQERLCGG-----GWEVERARLNA-------RLDQREREL 1556
E + A+LQE L G + E A+L L++ + +
Sbjct: 1028 AELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
Query: 1557 RAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIE 1616
+ ++ E H + R +E
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
Query: 1617 QS---EKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRE----RDNYKQMLEAAQ 1669
+S E+A +AE +GQ+ EL + ++ +RE R + +A
Sbjct: 1148 RSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAED 1207
Query: 1670 KSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCE-SRLLASKLNTE 1728
+ A++ G + A +NS+ S+ EEE V++L +QV E E E RL+ ++
Sbjct: 1208 EWKAQVARGRQEAE-RKNSLISSLEEE----VSILNRQVLEKEGESKELKRLVMAESEKS 1262
Query: 1729 LVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGL-ATRMELAWHKERDEQQRLLQE 1787
E+S A R + + E + LL R R +G A + +A R E +
Sbjct: 1263 QKLEESCACCR-QRQPATVPELQNAALLCGRRCRASGREAEKQRVASENLRQELTSQAER 1321
Query: 1788 TSTLARDLR 1796
L ++L+
Sbjct: 1322 AEELGQELK 1330
Score = 45.6 bits (103), Expect = 0.002
Identities = 67/306 (21%), Positives = 135/306 (44%), Gaps = 27/306 (8%)
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL--QVIEQ 842
E+ +R+K+ E+ER ++L AE + ++ L K+ L A + + + + L Q +E
Sbjct: 1408 ELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEV 1467
Query: 843 EASVLRAK-TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
E R K Q L A + E + ++ + A+S + + L++ T K + ++ E
Sbjct: 1468 ELDQAREKYVQELAA--VRADAETRLAEVQREAQS--TARELEVMTAKYEGAKVKVLEER 1523
Query: 902 AKIKE--LEMICQDEKSEKKVRFT-EATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQ 958
+ +E ++ Q E+ KK+ + +A+K + LK+ Q Q
Sbjct: 1524 QRFQEERQKLTAQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRFQAQLNELQ 1583
Query: 959 ATLKSLKDDAQKSFKPRIPKKPTDLTTKL--------------QLKKMVEDLECEIGEMY 1004
A L S K+ A + +K ++ K T K QL+K ++L E +
Sbjct: 1584 AQL-SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLG 1642
Query: 1005 VVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTN-EKNRLQTEIAKLKDVNAKL 1062
++ AGL KE + L ++ + ++++ D + + K ++ T+ K ++ AK
Sbjct: 1643 HELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKP 1702
Query: 1063 EGDKDV 1068
+ D +
Sbjct: 1703 QLDLSI 1708
Score = 43.2 bits (97), Expect = 0.010
Identities = 164/872 (18%), Positives = 345/872 (39%), Gaps = 72/872 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
KE +++ G K L + E + E +++L R LA A T S + +Q V
Sbjct: 755 KELEEERAGRKGLEARLLQLGEAHQAE-TEVLRRELAEAMAAQH--TAES----ECEQLV 807
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELET-RPSTEAQTRQIEQLRAKLLAAETLCEELM 385
E+ + D ++ Q + +L T + E +++++ + K+ E+ E +
Sbjct: 808 KEVAAWRDGYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQI 867
Query: 386 DENEDMKKELR-DLXXXXXXMQDNFREDQ--ADEYSSLRRELEQTIKNCRVLSFKLKKT- 441
++ EL +L +Q+ Q AD+ S+L+ ++ T K L ++K
Sbjct: 868 SRQQNKLAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAG 927
Query: 442 ---ERKADQLEQEKA---EHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
E + +L +E A + + + LE G + ++ +E+E + RL+
Sbjct: 928 EQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA 987
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE----AD 551
L E+ + + T + R+ + A+L LQ++L + A
Sbjct: 988 LMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1047
Query: 552 LREQLRNA-------EEETANCKQVNPPTFLDKQVMTDNIVTC--DIHESETVTNSIQNK 602
L+E L +A ++E A + + + + + + + + E S
Sbjct: 1048 LQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGA 1107
Query: 603 MIHAAS-TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
AA T + K ++ + K ++ Q + S+ + A A+R E D+
Sbjct: 1108 QSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD-SLERSLEAER----ASRAERDS 1162
Query: 662 --ESLLLQLKKMATK-ARSRKLSPTPPANKLSIETANDNDEKETDE--------ADPAEM 710
E+L QL++ A + S+ + + T + K DE AE
Sbjct: 1163 ALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAER 1222
Query: 711 K-LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
K L+ E+E ++L R+V E E + + LK+ V + K + ++ A R+
Sbjct: 1223 KNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEESCA----CCRQRQPA 1278
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKER-DCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+L + +L + EK+R E L EL+ ++ + L + L A +
Sbjct: 1279 TVPEL--QNAALLCGRRCRASGREAEKQRVASENLRQELTSQAERAEEL--GQELKAWQE 1334
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
+ ++ L ++ E TQ+L ++ + ++LQ + A R + L+ + +
Sbjct: 1335 KFFQKEQALSTLQLE----HTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQ 1390
Query: 889 KTTQLENELKEALAKIKEL----EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
L EL A ++ EL + + + E++ +++R +A+ E ++ K
Sbjct: 1391 AAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK--AHGLLA 1448
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEM 1003
+ L+ D A++ + + D T+L ++++ + E+ M
Sbjct: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
K G K + + + ++E ++ +++ + + + + + KLK V A+
Sbjct: 1509 --TAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLADSDQASKVQQQKLKAVQAQ-G 1565
Query: 1064 GDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
G+ A +++A NE +Q + E K
Sbjct: 1566 GESQQEAQRFQAQLNELQAQLSQKEQAAEHYK 1597
Score = 38.7 bits (86), Expect = 0.21
Identities = 52/248 (20%), Positives = 110/248 (44%), Gaps = 23/248 (9%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI--LLRRLANID-TANKYTTGRSS--EVLK 321
K +++++E KQ LR R ++E ++ L +++A + TA + ++S E L
Sbjct: 1379 KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLS 1438
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
+ +K + L E+ +L ++ E+E + +A+ + +++L A AET
Sbjct: 1439 MLKKAHGLLAEENRGLGERANLGRQFLEVELD-------QAREKYVQELAAVRADAETRL 1491
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQA---DEYSSLRRELEQTIKNC------- 431
E+ E + +EL + + E++ +E L ++E+ K
Sbjct: 1492 AEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLADSDQAS 1551
Query: 432 RVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALR 491
+V KLK + + + +QE + +L E+ ++ +L+ E A++ A +
Sbjct: 1552 KVQQQKLKAVQAQGGESQQEAQRFQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKK 1611
Query: 492 LQ-RELAE 498
Q +EL E
Sbjct: 1612 QQNQELQE 1619
>BC133019-1|AAI33020.1| 1427|Homo sapiens LOC650001 protein protein.
Length = 1427
Score = 68.1 bits (159), Expect = 3e-10
Identities = 148/823 (17%), Positives = 349/823 (42%), Gaps = 58/823 (7%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLAN-IDTANKYTTGRS--SE 318
+ +++++++++ L++E L+K ++ K+ + + + +N + + T G + ++
Sbjct: 495 LQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGND 554
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
L Q++ D R K +K E+++++ E +
Sbjct: 555 DDGLNQQIPRKENGEHD-RPADKTSNEK-NEVKNQIYPEADFADSMEPSEIASEDCELSH 612
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNF---------REDQADEYSSLRRELEQTIK 429
++ E M E ++ E +D +QD F + + D+ + +++E +
Sbjct: 613 SVYENFMLLIEQLRMEYKD-SASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVS 671
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVA 489
VL +L +T++ QLE +K E EK+L ++ +++EN K +
Sbjct: 672 ---VLQNELSETKKTKLQLELQKIEWEKELYDL---RLALKQENEEKRNADMLYNKDSEQ 725
Query: 490 LRLQRE----LAEANSKFTGSNPSLMKVPQP-----ETVKVSRSSLTRGGSQEDPAQLLR 540
LR++ E + E + + L+K + + V R+ + S+E A++L+
Sbjct: 726 LRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQ 785
Query: 541 DLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN-SI 599
D Q ++ +L + E ++ Q F + ++ + I + E +T+ N +
Sbjct: 786 D-QILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRL-EIDTIKNQNK 843
Query: 600 QNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN--LRKTAARV 657
Q + + + KEK+D+ I K EET L Y N++ A N L
Sbjct: 844 QKEKKYFEDIEAVKEKNDNLQ-KIIKLNEETLTETILQYSGQLNNLTAENKILNSELENG 902
Query: 658 EEDNESLLLQLK----KMATKARSRKLSPTPPANKLSIETAND-----NDEKETDEAD-P 707
+++ E L ++++ ++A R S T KL + +D+ + D +
Sbjct: 903 KQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQ 962
Query: 708 AEMKLLLE-LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR- 765
A+ ++L E L+ E+ + ++ +L ++AL ++ L +++T T +
Sbjct: 963 AKNEILSEKLSNAESKINSLQI-QLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMY 1021
Query: 766 SLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
+ + K + + +E+ + +++ + + + + H + + +Q+K + I+ + A
Sbjct: 1022 QIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKAN-SQEKTSSTIQDQFHSA 1080
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE--NKKLQLLKNAKSLRSDKAL 883
+ + ++Q+ ++++ L + L+ ++ + E +K+ L + +++ S + L
Sbjct: 1081 AKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPS-RCL 1139
Query: 884 DLNTK-KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXX 942
L+ + + QL+ L A K+ E + +++K K+ + E + L+ +
Sbjct: 1140 HLDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHK 1199
Query: 943 XXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT-KLQLKKMVEDLECEIG 1001
+ +L+ A S + + + + T+ K Q++ ++DLE EI
Sbjct: 1200 LLIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEIS 1259
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNE 1044
+ A + E+ +L E ++R LS N+ TNE
Sbjct: 1260 R--IKTSQADFNKTELERYKELYLEEVKVRESLS-NELSRTNE 1299
Score = 38.7 bits (86), Expect = 0.21
Identities = 48/243 (19%), Positives = 99/243 (40%), Gaps = 10/243 (4%)
Query: 1252 RDLKADYENKITSLEST---IAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXX 1308
++L+A+ E +I SL+ + + H+K+ D + + + T E V R
Sbjct: 1082 KNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHL 1141
Query: 1309 XXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXX 1368
Q L + K ++ E K QLK ++ L++
Sbjct: 1142 DAENEVLQLQQTLFSMKAIQKQCETLQKNKK----QLKQEVVNLKSYMERNMLERGKAEW 1197
Query: 1369 XSSYWENKA-KELDTDLQSERKKLDRMR-IAHDKDVKNKDAELATLKGKLKILEQNSGAG 1426
E +A KE++ L L + ++H++ V+ ++ ++K ++++ ++ +
Sbjct: 1198 HKLLIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESE 1257
Query: 1427 AKRITELKQEYEETVKKLEHSLALEKAEYEE-LTGKYELLEEEHVVTKARLTVEKEQAQG 1485
RI + ++ +T + L LE+ + E L+ + E +LTVEKEQ +
Sbjct: 1258 ISRIKTSQADFNKTELERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRS 1317
Query: 1486 ELL 1488
L
Sbjct: 1318 RSL 1320
Score = 38.3 bits (85), Expect = 0.28
Identities = 100/483 (20%), Positives = 193/483 (39%), Gaps = 39/483 (8%)
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEAD 706
A N ++ED E L K M + S + N S++ +N ++D
Sbjct: 430 ARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTN-----NYKSLKPKLENLSSLPPDSD 484
Query: 707 PAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRS 766
L E +Q+ + +V LE++ ALKK+ +L + + ++T +
Sbjct: 485 RTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGT 544
Query: 767 LTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKK--PKTLIKSRSLD 824
LT + ++ L +I RK+ E +R ++ E + + + P+ S++
Sbjct: 545 LTDGTTVGNDD--DGLNQQIP--RKENGEHDRPADKTSNEKNEVKNQIYPEADFAD-SME 599
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
S+ + D + V E ++ + D+ L L ++ L+++ D
Sbjct: 600 PSEIASEDCELSHSVYENFMLLIEQLRMEYK-DSASLPRIQDTFCLCEHLLKLKNNHC-D 657
Query: 885 LNTKKTTQLENE---LKEALAKIKELEMICQDEKSEKKVRFTE---ATKKETDTLKSKQX 938
T K Q+EN L+ L++ K+ ++ + +K E + + A K+E + ++
Sbjct: 658 QLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADM 717
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKP-RIPKKPTDLTTKLQ---LKKMVE 994
T + LK + ++ K R + DL + + K++ E
Sbjct: 718 LYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSE 777
Query: 995 DLECEIGEMYVVMKNAGLSGKEMT-AKTKLEKEIDEIRSK---LSKNDSEFTNEKNRLQT 1050
+ + I + ++ KE+ A+ K+ EI K L D E L+
Sbjct: 778 EQDARILQDQILTSKQ----KELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRL 833
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK----TLTEEMKNREAQINKLSA 1106
EI +K+ N + E K F + +A++ +N NL K TLTE + Q+N L+A
Sbjct: 834 EIDTIKNQNKQKE--KKYFED-IEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTA 890
Query: 1107 DLK 1109
+ K
Sbjct: 891 ENK 893
>BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 14
protein.
Length = 980
Score = 68.1 bits (159), Expect = 3e-10
Identities = 118/561 (21%), Positives = 233/561 (41%), Gaps = 39/561 (6%)
Query: 305 IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
I + K TT + +LQ+ + +L E E+K L +++ +EL +TE +
Sbjct: 417 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-S 475
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
L KL ++ EE M E ++K+++ L DN+ S EL
Sbjct: 476 ENSSDLSQKLKETQSKYEEAMKEVLSVQKQMK-LGLVSPESMDNY---------SHFHEL 525
Query: 425 EQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
T + VL L+ ++++ +++ E E+KL+E G + ++E E+ +
Sbjct: 526 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVE---REKGTVIKPPVEEYEEMKSS 582
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQD 544
V + +E A K+ + +MK+ +T+K S+ + ED + + + D
Sbjct: 583 YCSVIENMNKEKAFLFEKYQEAQEEIMKL--KDTLK-SQMTQEASDEAEDMKEAMNRMID 639
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
L ++ QL +E A + L+ V + I + + +TN + K
Sbjct: 640 ELNKQVSELSQL--YKEAQAELEDYRKRKSLE-DVTAEYIHKAEHEKLMQLTNVSRAKAE 696
Query: 605 HAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESL 664
A S S+ L+ K + Q +SI H+ +TAA+ E+
Sbjct: 697 DALSEMKSQYSKVLNELTQLKQLVDAQKENS---VSITEHLQVITTLRTAAKEMEE---- 749
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP-AEMKLLLELNEQEATV 723
++ + S+++ +L E A TD P + + L E E +V
Sbjct: 750 --KISNLKEHLASKEVEVAKLEKQLLEEKA-----AMTDAMVPRSSYEKLQSSLESEVSV 802
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L K++E ++KE + +V ++ S++S V K + T +S N+L ++ + E
Sbjct: 803 LASKLKESVKEKEKVHSEVVQIRSEVSQV-KREKENIQTLLKSKEQEVNELLQKFQQAQE 861
Query: 784 D--EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS-LDASDQQNVDLKRQLQVI 840
+ E+ + + E D ++ E+S K K + S S L S + +QL+ +
Sbjct: 862 ELAEMKRYSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEAL 921
Query: 841 EQEASVLRAKTQSLEADNEKL 861
+Q+ L+ + + ++++
Sbjct: 922 QQQVKQLQNQLAECKKQHQEV 942
Score = 52.4 bits (120), Expect = 2e-05
Identities = 73/421 (17%), Positives = 175/421 (41%), Gaps = 23/421 (5%)
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKI-----SSVTKTSAGSNTTARRSLT 768
L + E+E VL++ ++ ++ E K++V+EL K+ +V K + S
Sbjct: 525 LRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYC 584
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+ + +E+ + E + E ++++++ + + + + + + +R +D ++
Sbjct: 585 SVIENMNKEKAFLFE-KYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 643
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL-QTENKKLQLLKNAKSLRSDKALDLNT 887
Q +L + + + E R + + E + + E++KL L N +++ AL
Sbjct: 644 QVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDAL---- 699
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++++++ + L ++ +L+ + D + E V TE + T TL++
Sbjct: 700 ---SEMKSQYSKVLNELTQLKQLV-DAQKENSVSITEHLQVIT-TLRTAAKEMEEKISNL 754
Query: 948 XXXXXXXXXXQATL-KSLKDDAQKSFKPRIPKKPTD-LTTKLQ--LKKMVEDLECEIGEM 1003
A L K L ++ +P+ + L + L+ + + L+ + E
Sbjct: 755 KEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK 814
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK---DVNA 1060
V E++ + ++ I + + +E + + Q E+A++K + ++
Sbjct: 815 EKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYSESSS 874
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
KLE DKD N+ + N L+ + + Q +L A + LQ +++
Sbjct: 875 KLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAE 934
Query: 1121 C 1121
C
Sbjct: 935 C 935
Score = 47.2 bits (107), Expect = 6e-04
Identities = 91/483 (18%), Positives = 192/483 (39%), Gaps = 44/483 (9%)
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
Q+ L + + +LE +EAE ++E+ +++L L N + ++K
Sbjct: 435 QEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKET--QSKY 492
Query: 1378 KELDTDLQSERKKLDRMRIAHDK-DVKNKDAELATLKGKLKILE---QNSGAGAKRITEL 1433
+E ++ S +K++ ++ + D + EL + ++ +L+ QN+ ++R E
Sbjct: 493 EEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEK 552
Query: 1434 KQEYEETVKKLEHSLALEK--AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ 1491
+E EE + + E ++ EYEE+ Y + E KA L + ++AQ E++ ++
Sbjct: 553 VRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK 612
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
L + + + ++ A N E+ ++ L + E+E R L+
Sbjct: 613 DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 670
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E + +++ + Y +V
Sbjct: 671 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKV------------------LNE 712
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKS 1671
++Q A+K E + + T + + T+R K + ++S + + + + +K
Sbjct: 713 LTQLKQLVDAQK-ENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQ 771
Query: 1672 MAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVS 1731
+ E K A + R+S Y + LE +V+ L +L ES K+++E+V
Sbjct: 772 LLEEKAAMTDAMVPRSS--------YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVV- 822
Query: 1732 EKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTL 1791
++R Q + + + LL S V L + + A +E E +R + +S L
Sbjct: 823 -----QIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA-QEELAEMKRYSESSSKL 876
Query: 1792 ARD 1794
D
Sbjct: 877 EED 879
Score = 45.6 bits (103), Expect = 0.002
Identities = 90/498 (18%), Positives = 210/498 (42%), Gaps = 30/498 (6%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR-RLANIDTANKYTTGRSSEV 319
LV N E + L Q++ + + E KE + + +L + + E+
Sbjct: 466 LVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL 525
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
++++N L ++ +E + +K+RE+E +L R +E+ + +
Sbjct: 526 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCS 585
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ E + E + ++ ++ ++D + E S ++++ + R++ +L
Sbjct: 586 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMN--RMID-ELN 642
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVA-LRLQRELAE 498
K + QL +E A+ E + + + E K +++ + T V+ + + L+E
Sbjct: 643 KQVSELSQLYKE-AQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE 701
Query: 499 ANSKFTGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
S+++ L ++ Q + K + S+T + Q++ L+ + + ++ E++
Sbjct: 702 MKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITTLRTAAK---EMEEKIS 752
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
N +E A+ K+V L+KQ++ + D + +Q+ + S +SK K +
Sbjct: 753 NLKEHLAS-KEVEVAK-LEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLK-E 809
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
S +E Q ++ + N+ +T + +E + LLQ + A + +
Sbjct: 810 SVKEKEKVHSEVVQIRSEVSQVK----REKENI-QTLLKSKEQEVNELLQKFQQAQEELA 864
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE-QEATVLRRKVEELEQDKE 736
+ ++KL ++ +K+ +E KL LN + + + Q E
Sbjct: 865 EMKRYSESSSKL-----EEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLE 919
Query: 737 ALKKQVKELTSKISSVTK 754
AL++QVK+L ++++ K
Sbjct: 920 ALQQQVKQLQNQLAECKK 937
Score = 34.7 bits (76), Expect = 3.4
Identities = 55/271 (20%), Positives = 109/271 (40%), Gaps = 12/271 (4%)
Query: 1231 DELQARFI-KTE-SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
+++ A +I K E K + L R D +++ S S + + +KQL DA ++ +
Sbjct: 669 EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV 728
Query: 1289 DKYDEATSPVEMVE-MRXXXXXXXXXXXXXQDELNNAKI---KLEKTEAESSAAKLEMAQ 1344
T ++++ +R ++ L + ++ KLEK E AA +
Sbjct: 729 S----ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMV 784
Query: 1345 LKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN 1404
+S KL++ S + K ++SE ++ R + +K+
Sbjct: 785 PRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 844
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
K+ E+ L K + Q A KR +E + EE K + ++ E + +E
Sbjct: 845 KEQEVNELLQKFQ-QAQEELAEMKRYSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 903
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELS 1495
L +K R + + E Q ++ +Q +L+
Sbjct: 904 LSYSTSSSK-RQSQQLEALQQQVKQLQNQLA 933
>AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein.
Length = 983
Score = 68.1 bits (159), Expect = 3e-10
Identities = 118/561 (21%), Positives = 233/561 (41%), Gaps = 39/561 (6%)
Query: 305 IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
I + K TT + +LQ+ + +L E E+K L +++ +EL +TE +
Sbjct: 420 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-S 478
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
L KL ++ EE M E ++K+++ L DN+ S EL
Sbjct: 479 ENSSDLSQKLKETQSKYEEAMKEVLSVQKQMK-LGLVSPESMDNY---------SHFHEL 528
Query: 425 EQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
T + VL L+ ++++ +++ E E+KL+E G + ++E E+ +
Sbjct: 529 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVE---REKGTVIKPPVEEYEEMKSS 585
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQD 544
V + +E A K+ + +MK+ +T+K S+ + ED + + + D
Sbjct: 586 YCSVIENMNKEKAFLFEKYQEAQEEIMKL--KDTLK-SQMTQEASDEAEDMKEAMNRMID 642
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
L ++ QL +E A + L+ V + I + + +TN + K
Sbjct: 643 ELNKQVSELSQL--YKEAQAELEDYRKRKSLE-DVTAEYIHKAEHEKLMQLTNVSRAKAE 699
Query: 605 HAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESL 664
A S S+ L+ K + Q +SI H+ +TAA+ E+
Sbjct: 700 DALSEMKSQYSKVLNELTQLKQLVDAQKENS---VSITEHLQVITTLRTAAKEMEE---- 752
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP-AEMKLLLELNEQEATV 723
++ + S+++ +L E A TD P + + L E E +V
Sbjct: 753 --KISNLKEHLASKEVEVAKLEKQLLEEKA-----AMTDAMVPRSSYEKLQSSLESEVSV 805
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L K++E ++KE + +V ++ S++S V K + T +S N+L ++ + E
Sbjct: 806 LASKLKESVKEKEKVHSEVVQIRSEVSQV-KREKENIQTLLKSKEQEVNELLQKFQQAQE 864
Query: 784 D--EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS-LDASDQQNVDLKRQLQVI 840
+ E+ + + E D ++ E+S K K + S S L S + +QL+ +
Sbjct: 865 ELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEAL 924
Query: 841 EQEASVLRAKTQSLEADNEKL 861
+Q+ L+ + + ++++
Sbjct: 925 QQQVKQLQNQLAECKKQHQEV 945
Score = 52.4 bits (120), Expect = 2e-05
Identities = 73/421 (17%), Positives = 175/421 (41%), Gaps = 23/421 (5%)
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKI-----SSVTKTSAGSNTTARRSLT 768
L + E+E VL++ ++ ++ E K++V+EL K+ +V K + S
Sbjct: 528 LRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYC 587
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+ + +E+ + E + E ++++++ + + + + + + +R +D ++
Sbjct: 588 SVIENMNKEKAFLFE-KYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 646
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL-QTENKKLQLLKNAKSLRSDKALDLNT 887
Q +L + + + E R + + E + + E++KL L N +++ AL
Sbjct: 647 QVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDAL---- 702
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++++++ + L ++ +L+ + D + E V TE + T TL++
Sbjct: 703 ---SEMKSQYSKVLNELTQLKQLV-DAQKENSVSITEHLQVIT-TLRTAAKEMEEKISNL 757
Query: 948 XXXXXXXXXXQATL-KSLKDDAQKSFKPRIPKKPTD-LTTKLQ--LKKMVEDLECEIGEM 1003
A L K L ++ +P+ + L + L+ + + L+ + E
Sbjct: 758 KEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK 817
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK---DVNA 1060
V E++ + ++ I + + +E + + Q E+A++K + ++
Sbjct: 818 EKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSS 877
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
KLE DKD N+ + N L+ + + Q +L A + LQ +++
Sbjct: 878 KLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAE 937
Query: 1121 C 1121
C
Sbjct: 938 C 938
Score = 47.6 bits (108), Expect = 5e-04
Identities = 91/483 (18%), Positives = 192/483 (39%), Gaps = 44/483 (9%)
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
Q+ L + + +LE +EAE ++E+ +++L L N + ++K
Sbjct: 438 QEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKET--QSKY 495
Query: 1378 KELDTDLQSERKKLDRMRIAHDK-DVKNKDAELATLKGKLKILE---QNSGAGAKRITEL 1433
+E ++ S +K++ ++ + D + EL + ++ +L+ QN+ ++R E
Sbjct: 496 EEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEK 555
Query: 1434 KQEYEETVKKLEHSLALEK--AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ 1491
+E EE + + E ++ EYEE+ Y + E KA L + ++AQ E++ ++
Sbjct: 556 VRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK 615
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
L + + + ++ A N E+ ++ L + E+E R L+
Sbjct: 616 DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 673
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E + +++ + Y +V
Sbjct: 674 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKV------------------LNE 715
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKS 1671
++Q A+K E + + T + + T+R K + ++S + + + + +K
Sbjct: 716 LTQLKQLVDAQK-ENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQ 774
Query: 1672 MAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVS 1731
+ E K A + R+S Y + LE +V+ L +L ES K+++E+V
Sbjct: 775 LLEEKAAMTDAMVPRSS--------YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVV- 825
Query: 1732 EKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTL 1791
++R Q + + + LL S V L + + A +E E +R + +S L
Sbjct: 826 -----QIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA-QEELAEMKRYAESSSKL 879
Query: 1792 ARD 1794
D
Sbjct: 880 EED 882
Score = 45.2 bits (102), Expect = 0.002
Identities = 90/498 (18%), Positives = 209/498 (41%), Gaps = 30/498 (6%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR-RLANIDTANKYTTGRSSEV 319
LV N E + L Q++ + + E KE + + +L + + E+
Sbjct: 469 LVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL 528
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
++++N L ++ +E + +K+RE+E +L R +E+ + +
Sbjct: 529 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCS 588
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ E + E + ++ ++ ++D + E S ++++ + R++ +L
Sbjct: 589 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMN--RMID-ELN 645
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVA-LRLQRELAE 498
K + QL +E A+ E + + + E K +++ + T V+ + + L+E
Sbjct: 646 KQVSELSQLYKE-AQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE 704
Query: 499 ANSKFTGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
S+++ L ++ Q + K + S+T + Q++ L+ + + ++ E++
Sbjct: 705 MKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITTLRTAAK---EMEEKIS 755
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
N +E A+ K+V L+KQ++ + D + +Q+ + S +SK K +
Sbjct: 756 NLKEHLAS-KEVEVAK-LEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLK-E 812
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
S +E Q ++ + N+ +T + +E + LLQ + A + +
Sbjct: 813 SVKEKEKVHSEVVQIRSEVSQVK----REKENI-QTLLKSKEQEVNELLQKFQQAQEELA 867
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE-QEATVLRRKVEELEQDKE 736
++KL ++ +K+ +E KL LN + + + Q E
Sbjct: 868 EMKRYAESSSKL-----EEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLE 922
Query: 737 ALKKQVKELTSKISSVTK 754
AL++QVK+L ++++ K
Sbjct: 923 ALQQQVKQLQNQLAECKK 940
Score = 34.3 bits (75), Expect = 4.5
Identities = 55/271 (20%), Positives = 108/271 (39%), Gaps = 12/271 (4%)
Query: 1231 DELQARFI-KTE-SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
+++ A +I K E K + L R D +++ S S + + +KQL DA ++ +
Sbjct: 672 EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV 731
Query: 1289 DKYDEATSPVEMVE-MRXXXXXXXXXXXXXQDELNNAKI---KLEKTEAESSAAKLEMAQ 1344
T ++++ +R ++ L + ++ KLEK E AA +
Sbjct: 732 S----ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMV 787
Query: 1345 LKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN 1404
+S KL++ S + K ++SE ++ R + +K+
Sbjct: 788 PRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 847
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
K+ E+ L K + Q A KR E + EE K + ++ E + +E
Sbjct: 848 KEQEVNELLQKFQ-QAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 906
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELS 1495
L +K R + + E Q ++ +Q +L+
Sbjct: 907 LSYSTSSSK-RQSQQLEALQQQVKQLQNQLA 936
>AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment
epithelial cell protein protein.
Length = 980
Score = 68.1 bits (159), Expect = 3e-10
Identities = 118/561 (21%), Positives = 233/561 (41%), Gaps = 39/561 (6%)
Query: 305 IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
I + K TT + +LQ+ + +L E E+K L +++ +EL +TE +
Sbjct: 417 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-S 475
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
L KL ++ EE M E ++K+++ L DN+ S EL
Sbjct: 476 ENSSDLSQKLKETQSKYEEAMKEVLSVQKQMK-LGLVSPESMDNY---------SHFHEL 525
Query: 425 EQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
T + VL L+ ++++ +++ E E+KL+E G + ++E E+ +
Sbjct: 526 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVE---REKGTVIKPPVEEYEEMKSS 582
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQD 544
V + +E A K+ + +MK+ +T+K S+ + ED + + + D
Sbjct: 583 YCSVIENMNKEKAFLFEKYQEAQEEIMKL--KDTLK-SQMTQEASDEAEDMKEAMNRMID 639
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
L ++ QL +E A + L+ V + I + + +TN + K
Sbjct: 640 ELNKQVSELSQL--YKEAQAELEDYRKRKSLE-DVTAEYIHKAEHEKLMQLTNVSRAKAE 696
Query: 605 HAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESL 664
A S S+ L+ K + Q +SI H+ +TAA+ E+
Sbjct: 697 DALSEMKSQYSKVLNELTQLKQLVDAQKENS---VSITEHLQVITTLRTAAKEMEE---- 749
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP-AEMKLLLELNEQEATV 723
++ + S+++ +L E A TD P + + L E E +V
Sbjct: 750 --KISNLKEHLASKEVEVAKLEKQLLEEKA-----AMTDAMVPRSSYEKLQSSLESEVSV 802
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L K++E ++KE + +V ++ S++S V K + T +S N+L ++ + E
Sbjct: 803 LASKLKESVKEKEKVHSEVVQIRSEVSQV-KREKENIQTLLKSKEQEVNELLQKFQQAQE 861
Query: 784 D--EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS-LDASDQQNVDLKRQLQVI 840
+ E+ + + E D ++ E+S K K + S S L S + +QL+ +
Sbjct: 862 ELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEAL 921
Query: 841 EQEASVLRAKTQSLEADNEKL 861
+Q+ L+ + + ++++
Sbjct: 922 QQQVKQLQNQLAECKKQHQEV 942
Score = 52.4 bits (120), Expect = 2e-05
Identities = 73/421 (17%), Positives = 175/421 (41%), Gaps = 23/421 (5%)
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKI-----SSVTKTSAGSNTTARRSLT 768
L + E+E VL++ ++ ++ E K++V+EL K+ +V K + S
Sbjct: 525 LRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYC 584
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+ + +E+ + E + E ++++++ + + + + + + +R +D ++
Sbjct: 585 SVIENMNKEKAFLFE-KYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 643
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL-QTENKKLQLLKNAKSLRSDKALDLNT 887
Q +L + + + E R + + E + + E++KL L N +++ AL
Sbjct: 644 QVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDAL---- 699
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++++++ + L ++ +L+ + D + E V TE + T TL++
Sbjct: 700 ---SEMKSQYSKVLNELTQLKQLV-DAQKENSVSITEHLQVIT-TLRTAAKEMEEKISNL 754
Query: 948 XXXXXXXXXXQATL-KSLKDDAQKSFKPRIPKKPTD-LTTKLQ--LKKMVEDLECEIGEM 1003
A L K L ++ +P+ + L + L+ + + L+ + E
Sbjct: 755 KEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK 814
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK---DVNA 1060
V E++ + ++ I + + +E + + Q E+A++K + ++
Sbjct: 815 EKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSS 874
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
KLE DKD N+ + N L+ + + Q +L A + LQ +++
Sbjct: 875 KLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAE 934
Query: 1121 C 1121
C
Sbjct: 935 C 935
Score = 47.6 bits (108), Expect = 5e-04
Identities = 91/483 (18%), Positives = 192/483 (39%), Gaps = 44/483 (9%)
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
Q+ L + + +LE +EAE ++E+ +++L L N + ++K
Sbjct: 435 QEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKET--QSKY 492
Query: 1378 KELDTDLQSERKKLDRMRIAHDK-DVKNKDAELATLKGKLKILE---QNSGAGAKRITEL 1433
+E ++ S +K++ ++ + D + EL + ++ +L+ QN+ ++R E
Sbjct: 493 EEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEK 552
Query: 1434 KQEYEETVKKLEHSLALEK--AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ 1491
+E EE + + E ++ EYEE+ Y + E KA L + ++AQ E++ ++
Sbjct: 553 VRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK 612
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
L + + + ++ A N E+ ++ L + E+E R L+
Sbjct: 613 DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 670
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E + +++ + Y +V
Sbjct: 671 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKV------------------LNE 712
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKS 1671
++Q A+K E + + T + + T+R K + ++S + + + + +K
Sbjct: 713 LTQLKQLVDAQK-ENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQ 771
Query: 1672 MAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVS 1731
+ E K A + R+S Y + LE +V+ L +L ES K+++E+V
Sbjct: 772 LLEEKAAMTDAMVPRSS--------YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVV- 822
Query: 1732 EKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTL 1791
++R Q + + + LL S V L + + A +E E +R + +S L
Sbjct: 823 -----QIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA-QEELAEMKRYAESSSKL 876
Query: 1792 ARD 1794
D
Sbjct: 877 EED 879
Score = 45.2 bits (102), Expect = 0.002
Identities = 90/498 (18%), Positives = 209/498 (41%), Gaps = 30/498 (6%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR-RLANIDTANKYTTGRSSEV 319
LV N E + L Q++ + + E KE + + +L + + E+
Sbjct: 466 LVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL 525
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
++++N L ++ +E + +K+RE+E +L R +E+ + +
Sbjct: 526 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCS 585
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ E + E + ++ ++ ++D + E S ++++ + R++ +L
Sbjct: 586 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMN--RMID-ELN 642
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVA-LRLQRELAE 498
K + QL +E A+ E + + + E K +++ + T V+ + + L+E
Sbjct: 643 KQVSELSQLYKE-AQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE 701
Query: 499 ANSKFTGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
S+++ L ++ Q + K + S+T + Q++ L+ + + ++ E++
Sbjct: 702 MKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITTLRTAAK---EMEEKIS 752
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
N +E A+ K+V L+KQ++ + D + +Q+ + S +SK K +
Sbjct: 753 NLKEHLAS-KEVEVAK-LEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLK-E 809
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
S +E Q ++ + N+ +T + +E + LLQ + A + +
Sbjct: 810 SVKEKEKVHSEVVQIRSEVSQVK----REKENI-QTLLKSKEQEVNELLQKFQQAQEELA 864
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE-QEATVLRRKVEELEQDKE 736
++KL ++ +K+ +E KL LN + + + Q E
Sbjct: 865 EMKRYAESSSKL-----EEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLE 919
Query: 737 ALKKQVKELTSKISSVTK 754
AL++QVK+L ++++ K
Sbjct: 920 ALQQQVKQLQNQLAECKK 937
Score = 34.3 bits (75), Expect = 4.5
Identities = 55/271 (20%), Positives = 108/271 (39%), Gaps = 12/271 (4%)
Query: 1231 DELQARFI-KTE-SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
+++ A +I K E K + L R D +++ S S + + +KQL DA ++ +
Sbjct: 669 EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV 728
Query: 1289 DKYDEATSPVEMVE-MRXXXXXXXXXXXXXQDELNNAKI---KLEKTEAESSAAKLEMAQ 1344
T ++++ +R ++ L + ++ KLEK E AA +
Sbjct: 729 S----ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMV 784
Query: 1345 LKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN 1404
+S KL++ S + K ++SE ++ R + +K+
Sbjct: 785 PRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 844
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
K+ E+ L K + Q A KR E + EE K + ++ E + +E
Sbjct: 845 KEQEVNELLQKFQ-QAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 903
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELS 1495
L +K R + + E Q ++ +Q +L+
Sbjct: 904 LSYSTSSSK-RQSQQLEALQQQVKQLQNQLA 933
>AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein.
Length = 989
Score = 68.1 bits (159), Expect = 3e-10
Identities = 118/561 (21%), Positives = 233/561 (41%), Gaps = 39/561 (6%)
Query: 305 IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
I + K TT + +LQ+ + +L E E+K L +++ +EL +TE +
Sbjct: 426 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-S 484
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
L KL ++ EE M E ++K+++ L DN+ S EL
Sbjct: 485 ENSSDLSQKLKETQSKYEEAMKEVLSVQKQMK-LGLVSPESMDNY---------SHFHEL 534
Query: 425 EQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
T + VL L+ ++++ +++ E E+KL+E G + ++E E+ +
Sbjct: 535 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVE---REKGTVIKPPVEEYEEMKSS 591
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQD 544
V + +E A K+ + +MK+ +T+K S+ + ED + + + D
Sbjct: 592 YCSVIENMNKEKAFLFEKYQEAQEEIMKL--KDTLK-SQMTQEASDEAEDMKEAMNRMID 648
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
L ++ QL +E A + L+ V + I + + +TN + K
Sbjct: 649 ELNKQVSELSQL--YKEAQAELEDYRKRKSLE-DVTAEYIHKAEHEKLMQLTNVSRAKAE 705
Query: 605 HAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESL 664
A S S+ L+ K + Q +SI H+ +TAA+ E+
Sbjct: 706 DALSEMKSQYSKVLNELTQLKQLVDAQKENS---VSITEHLQVITTLRTAAKEMEE---- 758
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP-AEMKLLLELNEQEATV 723
++ + S+++ +L E A TD P + + L E E +V
Sbjct: 759 --KISNLKEHLASKEVEVAKLEKQLLEEKA-----AMTDAMVPRSSYEKLQSSLESEVSV 811
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L K++E ++KE + +V ++ S++S V K + T +S N+L ++ + E
Sbjct: 812 LASKLKESVKEKEKVHSEVVQIRSEVSQV-KREKENIQTLLKSKEQEVNELLQKFQQAQE 870
Query: 784 D--EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS-LDASDQQNVDLKRQLQVI 840
+ E+ + + E D ++ E+S K K + S S L S + +QL+ +
Sbjct: 871 ELAEMKRYSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEAL 930
Query: 841 EQEASVLRAKTQSLEADNEKL 861
+Q+ L+ + + ++++
Sbjct: 931 QQQVKQLQNQLAECKKQHQEV 951
Score = 52.4 bits (120), Expect = 2e-05
Identities = 73/421 (17%), Positives = 175/421 (41%), Gaps = 23/421 (5%)
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKI-----SSVTKTSAGSNTTARRSLT 768
L + E+E VL++ ++ ++ E K++V+EL K+ +V K + S
Sbjct: 534 LRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYC 593
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+ + +E+ + E + E ++++++ + + + + + + +R +D ++
Sbjct: 594 SVIENMNKEKAFLFE-KYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 652
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL-QTENKKLQLLKNAKSLRSDKALDLNT 887
Q +L + + + E R + + E + + E++KL L N +++ AL
Sbjct: 653 QVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDAL---- 708
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++++++ + L ++ +L+ + D + E V TE + T TL++
Sbjct: 709 ---SEMKSQYSKVLNELTQLKQLV-DAQKENSVSITEHLQVIT-TLRTAAKEMEEKISNL 763
Query: 948 XXXXXXXXXXQATL-KSLKDDAQKSFKPRIPKKPTD-LTTKLQ--LKKMVEDLECEIGEM 1003
A L K L ++ +P+ + L + L+ + + L+ + E
Sbjct: 764 KEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK 823
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK---DVNA 1060
V E++ + ++ I + + +E + + Q E+A++K + ++
Sbjct: 824 EKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYSESSS 883
Query: 1061 KLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSD 1120
KLE DKD N+ + N L+ + + Q +L A + LQ +++
Sbjct: 884 KLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAE 943
Query: 1121 C 1121
C
Sbjct: 944 C 944
Score = 47.2 bits (107), Expect = 6e-04
Identities = 91/483 (18%), Positives = 192/483 (39%), Gaps = 44/483 (9%)
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
Q+ L + + +LE +EAE ++E+ +++L L N + ++K
Sbjct: 444 QEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKET--QSKY 501
Query: 1378 KELDTDLQSERKKLDRMRIAHDK-DVKNKDAELATLKGKLKILE---QNSGAGAKRITEL 1433
+E ++ S +K++ ++ + D + EL + ++ +L+ QN+ ++R E
Sbjct: 502 EEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEK 561
Query: 1434 KQEYEETVKKLEHSLALEK--AEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ 1491
+E EE + + E ++ EYEE+ Y + E KA L + ++AQ E++ ++
Sbjct: 562 VRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK 621
Query: 1492 KELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQ 1551
L + + + ++ A N E+ ++ L + E+E R L+
Sbjct: 622 DTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 679
Query: 1552 RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXX 1611
E + +++ + Y +V
Sbjct: 680 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKV------------------LNE 721
Query: 1612 XXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKS 1671
++Q A+K E + + T + + T+R K + ++S + + + + +K
Sbjct: 722 LTQLKQLVDAQK-ENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQ 780
Query: 1672 MAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVS 1731
+ E K A + R+S Y + LE +V+ L +L ES K+++E+V
Sbjct: 781 LLEEKAAMTDAMVPRSS--------YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVV- 831
Query: 1732 EKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTL 1791
++R Q + + + LL S V L + + A +E E +R + +S L
Sbjct: 832 -----QIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA-QEELAEMKRYSESSSKL 885
Query: 1792 ARD 1794
D
Sbjct: 886 EED 888
Score = 45.6 bits (103), Expect = 0.002
Identities = 90/498 (18%), Positives = 210/498 (42%), Gaps = 30/498 (6%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR-RLANIDTANKYTTGRSSEV 319
LV N E + L Q++ + + E KE + + +L + + E+
Sbjct: 475 LVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL 534
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
++++N L ++ +E + +K+RE+E +L R +E+ + +
Sbjct: 535 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCS 594
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ E + E + ++ ++ ++D + E S ++++ + R++ +L
Sbjct: 595 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMN--RMID-ELN 651
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVA-LRLQRELAE 498
K + QL +E A+ E + + + E K +++ + T V+ + + L+E
Sbjct: 652 KQVSELSQLYKE-AQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE 710
Query: 499 ANSKFTGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
S+++ L ++ Q + K + S+T + Q++ L+ + + ++ E++
Sbjct: 711 MKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITTLRTAAK---EMEEKIS 761
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
N +E A+ K+V L+KQ++ + D + +Q+ + S +SK K +
Sbjct: 762 NLKEHLAS-KEVEVAK-LEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLK-E 818
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
S +E Q ++ + N+ +T + +E + LLQ + A + +
Sbjct: 819 SVKEKEKVHSEVVQIRSEVSQVK----REKENI-QTLLKSKEQEVNELLQKFQQAQEELA 873
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE-QEATVLRRKVEELEQDKE 736
+ ++KL ++ +K+ +E KL LN + + + Q E
Sbjct: 874 EMKRYSESSSKL-----EEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLE 928
Query: 737 ALKKQVKELTSKISSVTK 754
AL++QVK+L ++++ K
Sbjct: 929 ALQQQVKQLQNQLAECKK 946
Score = 34.7 bits (76), Expect = 3.4
Identities = 55/271 (20%), Positives = 109/271 (40%), Gaps = 12/271 (4%)
Query: 1231 DELQARFI-KTE-SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
+++ A +I K E K + L R D +++ S S + + +KQL DA ++ +
Sbjct: 678 EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV 737
Query: 1289 DKYDEATSPVEMVE-MRXXXXXXXXXXXXXQDELNNAKI---KLEKTEAESSAAKLEMAQ 1344
T ++++ +R ++ L + ++ KLEK E AA +
Sbjct: 738 S----ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMV 793
Query: 1345 LKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN 1404
+S KL++ S + K ++SE ++ R + +K+
Sbjct: 794 PRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 853
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
K+ E+ L K + Q A KR +E + EE K + ++ E + +E
Sbjct: 854 KEQEVNELLQKFQ-QAQEELAEMKRYSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 912
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELS 1495
L +K R + + E Q ++ +Q +L+
Sbjct: 913 LSYSTSSSK-RQSQQLEALQQQVKQLQNQLA 942
>AB027133-1|BAB71953.1| 1390|Homo sapiens male enhanced antigen-2
protein.
Length = 1390
Score = 68.1 bits (159), Expect = 3e-10
Identities = 174/877 (19%), Positives = 355/877 (40%), Gaps = 72/877 (8%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q + + L EVD L++ C +E+ +D L+ + ++ N ++++ +++ L
Sbjct: 460 QQRQDSLSSEVDTLKQSCWDLERAMTD--LQNM--LEAKNASLASSNNDLQVAEEQYQRL 515
Query: 330 TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ--LRAKLLAAETLCEELMDE 387
ED++ + ++ ++ T ++ Q Q+E+ L +KL A++ L
Sbjct: 516 MAKVEDMQRSMLSKDNTVHDLRQQM-TALQSQLQQVQLERTTLTSKLKASQAEISSLQSV 574
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
+ +++L +Q Q + + ++N LS +L +T+ ++
Sbjct: 575 RQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVS-LSQQLTETQHRS-- 631
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSN 507
+EK +L I D + +E ++++ T V LQR L E F G
Sbjct: 632 -MKEKGRIAAQLQGIEA--DMLDQEAAFMQIQEA---KTMVEEDLQRRLEE----FEGER 681
Query: 508 PSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLERE-ADLREQLRNAEEETAN 565
L ++ S +SL + Q L RD Q ++L++E DL +QL +E +
Sbjct: 682 ERLQRMAD------SAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQS 735
Query: 566 CKQVNPP--TFLDKQVMTDNIVTCDIHESETVTNSIQNKMI--HAA--STPSSKEKSDSP 619
+Q T D+ + + E +QN+ I AA + S KE+ D
Sbjct: 736 REQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRG 795
Query: 620 PLSIDKTTEETQFHFDL--PYLSIFNHMAANNLRKTAARVEEDNE--SLLLQLKKMATKA 675
+++ TEET + L+I + + ++TAA ++ + LQ K M
Sbjct: 796 ARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAY 855
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
R S ++L + E + + ++ E E + L R+V ++ Q
Sbjct: 856 RRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHM 915
Query: 736 EALKKQVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L+ ++ + + T + + T +N+ +++++ L+ E RK +
Sbjct: 916 ADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE---ARKAIT 972
Query: 795 EKERDCERLHAELSLAQKKPKTLIKS--RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
E+++ RL ++L+ AQK+ KT K+ ++ ++ + + + E LRA+
Sbjct: 973 EQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGG 1032
Query: 853 SLEAD---NEKLQTENKKLQLLKNAKSLR----------SDKALDLNTKKTTQLENELKE 899
S ++ +E++Q +LQ + ++K+L + + L+ + +K +LE+EL+E
Sbjct: 1033 SSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQE 1092
Query: 900 ALA---KIKELEMICQD---EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+ KIK LE + E +K + T + +
Sbjct: 1093 SRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQ----LKKMVEDLECEIGEMYVVMKN 1009
QA L+ K++ + K + L + + LK+ V + E G K
Sbjct: 1153 NLQVQAVLQR-KEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKA 1211
Query: 1010 AGLS----GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
A L KE+ AK L +++ L + + + E + Q E+A+ + L+
Sbjct: 1212 ASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQ 1271
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
D +K E NL + E+++ + Q++
Sbjct: 1272 LDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD 1308
Score = 63.7 bits (148), Expect = 6e-09
Identities = 124/612 (20%), Positives = 258/612 (42%), Gaps = 55/612 (8%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRP--STEAQTRQIEQLRAKLL 375
E ++L+ ++ L+ EK L ++ + ++L+ + S +Q RQ + L +++
Sbjct: 413 EKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQ-DSLSSEVD 471
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTI--KNC 431
+ C +L D++ L ++ + E+Q + ++++++ K+
Sbjct: 472 TLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDN 531
Query: 432 RVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKE-LEQEVARSTEVAL 490
V + + T ++ QL+Q + E ++ + +++ +Q++A + E +
Sbjct: 532 TVHDLRQQMTALQS-QLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARV 590
Query: 491 RLQRELAEANSKFTGSNPSLMKVPQPETVKVSRS-SLTRGGSQEDPAQLLRDLQDSLERE 549
RLQ E+A + L++ + E V +S+ + T+ S ++ ++ LQ E
Sbjct: 591 RLQGEMAHIQVGQM-TQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGI---E 646
Query: 550 ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAAST 609
AD+ +Q A Q+ + + M + + + E E +Q AAS
Sbjct: 647 ADMLDQ-------EAAFMQIQ-----EAKTMVEEDLQRRLEEFEGERERLQRMADSAASL 694
Query: 610 PSSKEKSDSPPLSIDKTTEETQF-HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQL 668
E+ L D+ E Q H DL A + ++ ++ + L +L
Sbjct: 695 EQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARL 754
Query: 669 KKMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEADPAEMKL---------LLELNE 718
++ +A SR+ + N K+ +E A + +E D +L LE
Sbjct: 755 GELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLR 814
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
+E + +VE L+Q+ ALKKQ++++ + K RR T+ ++E +
Sbjct: 815 EELAIKSGQVEHLQQETAALKKQMQKIKEQFLQ-QKVMV---EAYRRDATSKDQLISELK 870
Query: 779 V--KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ 836
K L+ E+ E+R++L++ + AELS R + Q DL+
Sbjct: 871 ATRKRLDSELKELRQELMQVHGEKRTAEAELSRLH---------REVAQVRQHMADLEGH 921
Query: 837 LQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL-KNAKSLRSD--KALDLNTKKTTQL 893
LQ ++E + QSL+ D E++ + + L K + L+ + KA+ +K +L
Sbjct: 922 LQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRL 981
Query: 894 ENELKEALAKIK 905
++L A ++K
Sbjct: 982 GSDLTSAQKEMK 993
Score = 54.8 bits (126), Expect = 3e-06
Identities = 121/684 (17%), Positives = 268/684 (39%), Gaps = 61/684 (8%)
Query: 787 DEVRKKLIEKERDCERLHA--------ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
++++++L E E + ERL E L Q K L + + L+A Q+++DL +QL
Sbjct: 668 EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLT 727
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQ-----------LLKNAK-----SLRSDKA 882
+ ++ +L+ ++LQ +LQ LL+N K +L++ K+
Sbjct: 728 LTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKS 787
Query: 883 ----LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK---- 934
LD ++ + E E L K++E E+ + + E + T A KK+ +K
Sbjct: 788 GKEELDRGARRLEEGTEETSETLEKLRE-ELAIKSGQVEHLQQETAALKKQMQKIKEQFL 846
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM-- 992
++ +AT K L + ++ + + T + +L ++
Sbjct: 847 QQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHR 906
Query: 993 -VEDLECEIGEMYVVMKNAGLSGKEMTA---KTKLEKE----IDEIRSKLSKNDSEFTNE 1044
V + + ++ +++A EM + +KE + E L K E E
Sbjct: 907 EVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
Query: 1045 KNRLQTE-IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
+ TE K++ + + L + K+KA EN LS + + + +A++ +
Sbjct: 967 ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
Query: 1104 LSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT--KIDQDKNKLLK 1161
L A ++ S + + + +V T ++++ + K+L
Sbjct: 1027 LRAQGGSSDS-SLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVL- 1084
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
E+ D+ ++ K++ +L K ++T +L +
Sbjct: 1085 ELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAK 1144
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYE---NKITSLESTIAAKDVHIKQ 1278
+L ++QA + E + ++ ++ L+A E K+ SL+ +AA V
Sbjct: 1145 READLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGH 1204
Query: 1279 LEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAA 1338
N ++ +A S +E+ E++ Q E ++ +I+ K E +
Sbjct: 1205 ---------NRRHFKAAS-LELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQF 1254
Query: 1339 KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAH 1398
+ E+A+ ++ L L+ + + + + ++QS +++LD
Sbjct: 1255 QAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQG 1314
Query: 1399 DKDVKNKDAELATLKGKLKILEQN 1422
K+++ L +K +L++ +++
Sbjct: 1315 RKELEGLQQLLQNVKSELEMAQED 1338
Score = 54.4 bits (125), Expect = 4e-06
Identities = 113/658 (17%), Positives = 264/658 (40%), Gaps = 45/658 (6%)
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
++ T+ + ++ EQ +AL+ EL +++ + +A T L N + E
Sbjct: 724 KQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI--CLLQNEKIILEAA 781
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
++ + +E+ + E E +L + + + IKS ++ Q+ LK+Q+Q
Sbjct: 782 LQAAKSGKEELDRGARRLEEGTEETSE--TLEKLREELAIKSGQVEHLQQETAALKKQMQ 839
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
I+++ L+ K +EA ++++ + LK + R D L ++ Q+ E +
Sbjct: 840 KIKEQ--FLQQKVM-VEAYRRDATSKDQLISELKATRK-RLDSELKELRQELMQVHGEKR 895
Query: 899 EALAKIKELEM-ICQDEKSEKKVR-FTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
A A++ L + Q + + ++ +KE D +++
Sbjct: 896 TAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEA 955
Query: 957 XQATLKSLKDDAQKSF---KPRIPKKPTDLTT-KLQLKKMVEDLECEIGEMYVVMKNAGL 1012
+ ++ L+ +A+K+ K ++ + +DLT+ + ++K + E +G + ++ A
Sbjct: 956 LKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA-- 1013
Query: 1013 SGKEMTAKTKLEKEIDEIRSKLSKNDSEFT-NEK-NRLQTEIAKLKDVNAKLEGD-KDVF 1069
+ AK + E+ ++R++ +DS +E+ L+ E+ + LE + ++V
Sbjct: 1014 ----LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVI 1069
Query: 1070 ANKYKALENENSNLSN------QCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMX 1123
A + LE + + + +++K E KL+ +L++ T +
Sbjct: 1070 ALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNA 1129
Query: 1124 XXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKK--IGDXXXXXXXXX 1181
Q++ + + KE D+ K +
Sbjct: 1130 ALREHNSILETALAKREADLVQLNLQVQAVLQR----KEEEDRQMKHLVQALQASLEKEK 1185
Query: 1182 XXCKRIEKQLSTRK-----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQAR 1236
+++Q++ K +R + + A H L +L +E D+LQ R
Sbjct: 1186 EKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEH--LVQKLQAEADDLQIR 1243
Query: 1237 FIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS 1296
K + +AE+ + +A + L+ ++ + V +++E+ L+ + K E S
Sbjct: 1244 EGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMEN-LKWEVDQKEREIQS 1302
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLEN 1354
+ +++ Q L N K +LE + + S + + L++ +++L+N
Sbjct: 1303 LKQQLDL--TEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKN 1358
Score = 50.8 bits (116), Expect = 5e-05
Identities = 182/976 (18%), Positives = 369/976 (37%), Gaps = 76/976 (7%)
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSD-KALDLNTKKTTQLENELKEALAKIKELEMIC 911
S+ ++ +T+ + LQ+LK L +AL L + + + EL+ LA + ++
Sbjct: 393 SVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALST-KLQA 451
Query: 912 QDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
Q E S + ++ E DTLK A+ + A++
Sbjct: 452 QVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQ 511
Query: 972 FKPRIPKKPTDLTTKLQLK-KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK-EIDE 1029
++ R+ K D+ + K V DL ++ + ++ L +T+K K + EI
Sbjct: 512 YQ-RLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISS 570
Query: 1030 IRSKLSKNDSEFT---NEKNRLQTEIAKLKD---------VNAKLEG---DKDVFANKYK 1074
++S + + RLQ E+A ++ + KLE + + +++
Sbjct: 571 LQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHR 630
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLS-ADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
+++ E ++ Q + + +M ++EA ++ A LQ + +
Sbjct: 631 SMK-EKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMAD 689
Query: 1134 XXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLST 1193
+ DQ L +E D K++ ++
Sbjct: 690 SAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDE 749
Query: 1194 RKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELT---SEKDELQ--ARFIK--TESKFIT 1246
+ R+ +L N L L S K+EL AR ++ TE T
Sbjct: 750 LQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSET 809
Query: 1247 LEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQ--TTNDKYD-EATSPVEMV-E 1302
LE ++R+ A ++ L+ AA ++++++ Q + Y +ATS +++ E
Sbjct: 810 LE-KLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISE 868
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
++ + EL + EAE S E+AQ++ +A LE
Sbjct: 869 LKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSA--- 925
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ + E++T LQS + ++M V +A A LK +++ L+Q
Sbjct: 926 -----------QKERDEMETHLQSLQFDKEQM-------VAVTEANEA-LKKQIEELQQE 966
Query: 1423 SGAGAKRITELKQEYEETVKKL---EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVE 1479
+ K ITE KQ+ L + + + YE G +E + K E
Sbjct: 967 A---RKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAE 1023
Query: 1480 KEQAQGELLHVQKELSTALGE-IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGG- 1537
Q + + + S AL E I+ L+ +L S + + E+Q IA + L
Sbjct: 1024 LGQLRAQ--GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
Query: 1538 --WEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQR 1595
E+E +R +++ + ++++ LE H+ E S ++
Sbjct: 1082 KVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALR-EHNSILET 1140
Query: 1596 XXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFR 1655
+++ E+ + ++ + + ++++ SL QV+ +
Sbjct: 1141 ALAKREADLVQLNLQVQAVLQRKEEEDR-QMKHLVQALQASLEKEKEKVNSLKEQVAAAK 1199
Query: 1656 RERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDEL 1715
E + ++ +AA ++E+K + A+ H + ++ + + Q++A + EL
Sbjct: 1200 VEAGHNRRHFKAASLELSEVKK-ELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAEL 1258
Query: 1716 CESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEE-ERLLSSGRARVAGLATRMELAW 1774
E+R L +L + S V EM++ E ++ ER + S + ++ E
Sbjct: 1259 AEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQL----DLTEQQG 1314
Query: 1775 HKERDEQQRLLQETST 1790
KE + Q+LLQ +
Sbjct: 1315 RKELEGLQQLLQNVKS 1330
>D63997-1|BAA23661.1| 1530|Homo sapiens GCP170 protein.
Length = 1530
Score = 67.7 bits (158), Expect = 4e-10
Identities = 174/877 (19%), Positives = 355/877 (40%), Gaps = 72/877 (8%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
Q + + L EVD L++ C +E+ +D L+ + ++ N ++++ +++ L
Sbjct: 460 QQRQDSLSSEVDTLKQSCWDLERAMTD--LQNM--LEAKNASLASSNNDLQVAEEQYQRL 515
Query: 330 TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ--LRAKLLAAETLCEELMDE 387
ED++ + ++ ++ T ++ Q Q+E+ L +KL A++ L
Sbjct: 516 MAKVEDMQRSMLSKDNTVHDLRQQM-TALQSQLQQVQLERTTLTSKLKASQAEISSLQSV 574
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
+ +++L +Q Q + + ++N LS +L +T+ ++
Sbjct: 575 RQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGILEHLKLENVS-LSQQLTETQHRS-- 631
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSN 507
+EK +L I D + +E ++++ T V LQR L E F G
Sbjct: 632 -MKEKGRIAAQLQGIEA--DMLDQEAAFMQIQEA---KTMVEEDLQRRLEE----FEGER 681
Query: 508 PSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ-DSLERE-ADLREQLRNAEEETAN 565
L ++ S +SL + Q L RD Q ++L++E DL +QL +E +
Sbjct: 682 ERLQRMAD------SAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQS 735
Query: 566 CKQVNPP--TFLDKQVMTDNIVTCDIHESETVTNSIQNKMI--HAA--STPSSKEKSDSP 619
+Q T D+ + + E +QN+ I AA + S KE+ D
Sbjct: 736 REQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRG 795
Query: 620 PLSIDKTTEETQFHFDL--PYLSIFNHMAANNLRKTAARVEEDNE--SLLLQLKKMATKA 675
+++ TEET + L+I + + ++TAA ++ + LQ K M
Sbjct: 796 ARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAY 855
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
R S ++L + E + + ++ E E + L R+V ++ Q
Sbjct: 856 RRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHM 915
Query: 736 EALKKQVKELTSKISSV-TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLI 794
L+ ++ + + T + + T +N+ +++++ L+ E RK +
Sbjct: 916 ADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE---ARKAIT 972
Query: 795 EKERDCERLHAELSLAQKKPKTLIKS--RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
E+++ RL ++L+ AQK+ KT K+ ++ ++ + + + E LRA+
Sbjct: 973 EQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGG 1032
Query: 853 SLEAD---NEKLQTENKKLQLLKNAKSLR----------SDKALDLNTKKTTQLENELKE 899
S ++ +E++Q +LQ + ++K+L + + L+ + +K +LE+EL+E
Sbjct: 1033 SSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQE 1092
Query: 900 ALA---KIKELEMICQD---EKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXX 953
+ KIK LE + E +K + T + +
Sbjct: 1093 SRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
Query: 954 XXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQ----LKKMVEDLECEIGEMYVVMKN 1009
QA L+ K++ + K + L + + LK+ V + E G K
Sbjct: 1153 NLQVQAVLQR-KEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKA 1211
Query: 1010 AGLS----GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD 1065
A L KE+ AK L +++ L + + + E + Q E+A+ + L+
Sbjct: 1212 ASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQ 1271
Query: 1066 KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
D +K E NL + E+++ + Q++
Sbjct: 1272 LDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD 1308
Score = 63.3 bits (147), Expect = 9e-09
Identities = 121/611 (19%), Positives = 255/611 (41%), Gaps = 53/611 (8%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRP--STEAQTRQIEQLRAKLL 375
E ++L+ ++ L+ EK L ++ + ++L+ + S +Q RQ + L +++
Sbjct: 413 EKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQ-DSLSSEVD 471
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTI--KNC 431
+ C +L D++ L ++ + E+Q + ++++++ K+
Sbjct: 472 TLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDN 531
Query: 432 RVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKE-LEQEVARSTEVAL 490
V + + T ++ QL+Q + E ++ + +++ +Q++A + E +
Sbjct: 532 TVHDLRQQMTALQS-QLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARV 590
Query: 491 RLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREA 550
RLQ E+A G + + E +K+ SL++ QL S++ +
Sbjct: 591 RLQGEMAHIQ---VGQ---MTQAGILEHLKLENVSLSQ--------QLTETQHRSMKEKG 636
Query: 551 DLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTP 610
+ QL+ E + + ++ + + M + + + E E +Q AAS
Sbjct: 637 RIAAQLQGIEADMLD-QEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLE 695
Query: 611 SSKEKSDSPPLSIDKTTEETQF-HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
E+ L D+ E Q H DL A + ++ ++ + L +L
Sbjct: 696 QQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLG 755
Query: 670 KMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEADPAEMKL---------LLELNEQ 719
++ +A SR+ + N K+ +E A + +E D +L LE +
Sbjct: 756 ELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLRE 815
Query: 720 EATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERV 779
E + +VE L+Q+ ALKKQ++++ + K RR T+ ++E +
Sbjct: 816 ELAIKSGQVEHLQQETAALKKQMQKIKEQFLQ-QKVMV---EAYRRDATSKDQLISELKA 871
Query: 780 --KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
K L+ E+ E+R++L++ + AELS R + Q DL+ L
Sbjct: 872 TRKRLDSELKELRQELMQVHGEKRTAEAELSRLH---------REVAQVRQHMADLEGHL 922
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL-KNAKSLRSD--KALDLNTKKTTQLE 894
Q ++E + QSL+ D E++ + + L K + L+ + KA+ +K +L
Sbjct: 923 QSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLG 982
Query: 895 NELKEALAKIK 905
++L A ++K
Sbjct: 983 SDLTSAQKEMK 993
Score = 54.8 bits (126), Expect = 3e-06
Identities = 121/684 (17%), Positives = 268/684 (39%), Gaps = 61/684 (8%)
Query: 787 DEVRKKLIEKERDCERLHA--------ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
++++++L E E + ERL E L Q K L + + L+A Q+++DL +QL
Sbjct: 668 EDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLT 727
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQ-----------LLKNAK-----SLRSDKA 882
+ ++ +L+ ++LQ +LQ LL+N K +L++ K+
Sbjct: 728 LTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKS 787
Query: 883 ----LDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK---- 934
LD ++ + E E L K++E E+ + + E + T A KK+ +K
Sbjct: 788 GKEELDRGARRLEEGTEETSETLEKLRE-ELAIKSGQVEHLQQETAALKKQMQKIKEQFL 846
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKM-- 992
++ +AT K L + ++ + + T + +L ++
Sbjct: 847 QQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHR 906
Query: 993 -VEDLECEIGEMYVVMKNAGLSGKEMTA---KTKLEKE----IDEIRSKLSKNDSEFTNE 1044
V + + ++ +++A EM + +KE + E L K E E
Sbjct: 907 EVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE 966
Query: 1045 KNRLQTE-IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK 1103
+ TE K++ + + L + K+KA EN LS + + + +A++ +
Sbjct: 967 ARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ 1026
Query: 1104 LSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYT--KIDQDKNKLLK 1161
L A ++ S + + + +V T ++++ + K+L
Sbjct: 1027 LRAQGGSSDS-SLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVL- 1084
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
E+ D+ ++ K++ +L K ++T +L +
Sbjct: 1085 ELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAK 1144
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYE---NKITSLESTIAAKDVHIKQ 1278
+L ++QA + E + ++ ++ L+A E K+ SL+ +AA V
Sbjct: 1145 READLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGH 1204
Query: 1279 LEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAA 1338
N ++ +A S +E+ E++ Q E ++ +I+ K E +
Sbjct: 1205 ---------NRRHFKAAS-LELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQF 1254
Query: 1339 KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAH 1398
+ E+A+ ++ L L+ + + + + ++QS +++LD
Sbjct: 1255 QAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQG 1314
Query: 1399 DKDVKNKDAELATLKGKLKILEQN 1422
K+++ L +K +L++ +++
Sbjct: 1315 RKELEGLQQLLQNVKSELEMAQED 1338
Score = 54.4 bits (125), Expect = 4e-06
Identities = 113/658 (17%), Positives = 264/658 (40%), Gaps = 45/658 (6%)
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
++ T+ + ++ EQ +AL+ EL +++ + +A T L N + E
Sbjct: 724 KQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI--CLLQNEKIILEAA 781
Query: 779 VKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
++ + +E+ + E E +L + + + IKS ++ Q+ LK+Q+Q
Sbjct: 782 LQAAKSGKEELDRGARRLEEGTEETSE--TLEKLREELAIKSGQVEHLQQETAALKKQMQ 839
Query: 839 VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELK 898
I+++ L+ K +EA ++++ + LK + R D L ++ Q+ E +
Sbjct: 840 KIKEQ--FLQQKVM-VEAYRRDATSKDQLISELKATRK-RLDSELKELRQELMQVHGEKR 895
Query: 899 EALAKIKELEM-ICQDEKSEKKVR-FTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
A A++ L + Q + + ++ +KE D +++
Sbjct: 896 TAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEA 955
Query: 957 XQATLKSLKDDAQKSF---KPRIPKKPTDLTT-KLQLKKMVEDLECEIGEMYVVMKNAGL 1012
+ ++ L+ +A+K+ K ++ + +DLT+ + ++K + E +G + ++ A
Sbjct: 956 LKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA-- 1013
Query: 1013 SGKEMTAKTKLEKEIDEIRSKLSKNDSEFT-NEK-NRLQTEIAKLKDVNAKLEGD-KDVF 1069
+ AK + E+ ++R++ +DS +E+ L+ E+ + LE + ++V
Sbjct: 1014 ----LAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVI 1069
Query: 1070 ANKYKALENENSNLSN------QCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMX 1123
A + LE + + + +++K E KL+ +L++ T +
Sbjct: 1070 ALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNA 1129
Query: 1124 XXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKK--IGDXXXXXXXXX 1181
Q++ + + KE D+ K +
Sbjct: 1130 ALREHNSILETALAKREADLVQLNLQVQAVLQR----KEEEDRQMKHLVQALQASLEKEK 1185
Query: 1182 XXCKRIEKQLSTRK-----DRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQAR 1236
+++Q++ K +R + + A H L +L +E D+LQ R
Sbjct: 1186 EKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEH--LVQKLQAEADDLQIR 1243
Query: 1237 FIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS 1296
K + +AE+ + +A + L+ ++ + V +++E+ L+ + K E S
Sbjct: 1244 EGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMEN-LKWEVDQKEREIQS 1302
Query: 1297 PVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLEN 1354
+ +++ Q L N K +LE + + S + + L++ +++L+N
Sbjct: 1303 LKQQLDL--TEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKN 1358
Score = 50.8 bits (116), Expect = 5e-05
Identities = 182/976 (18%), Positives = 369/976 (37%), Gaps = 76/976 (7%)
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSD-KALDLNTKKTTQLENELKEALAKIKELEMIC 911
S+ ++ +T+ + LQ+LK L +AL L + + + EL+ LA + ++
Sbjct: 393 SVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALST-KLQA 451
Query: 912 QDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKS 971
Q E S + ++ E DTLK A+ + A++
Sbjct: 452 QVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQ 511
Query: 972 FKPRIPKKPTDLTTKLQLK-KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK-EIDE 1029
++ R+ K D+ + K V DL ++ + ++ L +T+K K + EI
Sbjct: 512 YQ-RLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISS 570
Query: 1030 IRSKLSKNDSEFT---NEKNRLQTEIAKLKD---------VNAKLEG---DKDVFANKYK 1074
++S + + RLQ E+A ++ + KLE + + +++
Sbjct: 571 LQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGILEHLKLENVSLSQQLTETQHR 630
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLS-ADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
+++ E ++ Q + + +M ++EA ++ A LQ + +
Sbjct: 631 SMK-EKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMAD 689
Query: 1134 XXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLST 1193
+ DQ L +E D K++ ++
Sbjct: 690 SAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDE 749
Query: 1194 RKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELT---SEKDELQ--ARFIK--TESKFIT 1246
+ R+ +L N L L S K+EL AR ++ TE T
Sbjct: 750 LQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSET 809
Query: 1247 LEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQ--TTNDKYD-EATSPVEMV-E 1302
LE ++R+ A ++ L+ AA ++++++ Q + Y +ATS +++ E
Sbjct: 810 LE-KLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISE 868
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
++ + EL + EAE S E+AQ++ +A LE
Sbjct: 869 LKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSA--- 925
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQN 1422
+ + E++T LQS + ++M V +A A LK +++ L+Q
Sbjct: 926 -----------QKERDEMETHLQSLQFDKEQM-------VAVTEANEA-LKKQIEELQQE 966
Query: 1423 SGAGAKRITELKQEYEETVKKL---EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVE 1479
+ K ITE KQ+ L + + + YE G +E + K E
Sbjct: 967 A---RKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAE 1023
Query: 1480 KEQAQGELLHVQKELSTALGE-IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGG- 1537
Q + + + S AL E I+ L+ +L S + + E+Q IA + L
Sbjct: 1024 LGQLRAQ--GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESRE 1081
Query: 1538 --WEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQR 1595
E+E +R +++ + ++++ LE H+ E S ++
Sbjct: 1082 KVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALR-EHNSILET 1140
Query: 1596 XXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFR 1655
+++ E+ + ++ + + ++++ SL QV+ +
Sbjct: 1141 ALAKREADLVQLNLQVQAVLQRKEEEDR-QMKHLVQALQASLEKEKEKVNSLKEQVAAAK 1199
Query: 1656 RERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDEL 1715
E + ++ +AA ++E+K + A+ H + ++ + + Q++A + EL
Sbjct: 1200 VEAGHNRRHFKAASLELSEVKK-ELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAEL 1258
Query: 1716 CESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEE-ERLLSSGRARVAGLATRMELAW 1774
E+R L +L + S V EM++ E ++ ER + S + ++ E
Sbjct: 1259 AEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQL----DLTEQQG 1314
Query: 1775 HKERDEQQRLLQETST 1790
KE + Q+LLQ +
Sbjct: 1315 RKELEGLQQLLQNVKS 1330
>BC013023-1|AAH13023.1| 1193|Homo sapiens NUMA1 protein protein.
Length = 1193
Score = 67.7 bits (158), Expect = 4e-10
Identities = 128/647 (19%), Positives = 264/647 (40%), Gaps = 53/647 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEV-LKLQQKVNELT 330
++E L+Q V L+++ + EKE A+ A GR+ KL+ E++
Sbjct: 171 ELEELRQTVKQLKEQLAKKEKEH--------ASGSGAQSEAAGRTEPTGPKLEALRAEVS 222
Query: 331 THNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENED 390
+ + +++ R +E+E +R ++ +E L+ +L E +EL
Sbjct: 223 KLEQQCQKQQEQADSLERSLEAERASRAERDSA---LETLQGQL---EEKAQELGHSQSA 276
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
+ R+L +QD+ + + + R E KN + S + + + LE+
Sbjct: 277 LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEK 336
Query: 451 EKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
E E K L + + E R++ L+ E A ++ A AE +S SL
Sbjct: 337 EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA-------AERSSALREEVQSL 389
Query: 511 MKVPQPETVKVS--RSSLTRGGSQ-EDPAQLLRDLQDSLEREADLREQLRNAEEET-ANC 566
+ + + V R LT + E+ Q L+ Q+ ++ L+ T A
Sbjct: 390 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 449
Query: 567 KQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKT 626
++ P L +Q+ + H E + + A + +E + PL K
Sbjct: 450 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGALRAELLRAQRELGELIPLR-QKV 508
Query: 627 TEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE------SLLLQLKKMATKARSRKL 680
E+ + L + L+K + E+N +L Q ++ K
Sbjct: 509 AEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKY 568
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKK 740
A + ET ++E ++ E++++ E + + + +++++ L
Sbjct: 569 VQELAAVRADAETRLAEVQREA-QSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTA 627
Query: 741 QVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDC 800
QV+EL+ K++ + S + +++ + L+ +++E++ +L +KE+
Sbjct: 628 QVEELSKKLADSDQASKVQQQKLKAVQAQGGE--SQQEAQRLQAQLNELQAQLSQKEQAA 685
Query: 801 ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK 860
E H +L + +K KT DA QQN +L+ QL+ +EQ L+ + + L A+ E+
Sbjct: 686 E--HYKLQM--EKAKT-----HYDAKKQQNQELQEQLRSLEQ----LQKENKELRAEAER 732
Query: 861 LQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
L E ++ L K+ +++ T + LE ++ A ++++L
Sbjct: 733 LGHELQQAGL----KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 775
Score = 43.2 bits (97), Expect = 0.010
Identities = 89/425 (20%), Positives = 164/425 (38%), Gaps = 31/425 (7%)
Query: 1385 QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEE-TVKK 1443
Q + L+R A +D+ L TL+G+L+ Q G + ++E K
Sbjct: 232 QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 291
Query: 1444 LEHSLALE--KAEY----EELTGKYELLE--EEHVVTKARLTVEKEQAQGE---LLHVQK 1492
+HS A + KA+ +E K L+ EE V R +EKE E L+ +
Sbjct: 292 QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAES 351
Query: 1493 ELSTALGE-IKTLQEKLGTESAAWNTEKTEMQNSIASLQE-----RLCGGGWEVERARLN 1546
E S L E ++ LQ + + SA + ++ + SL+E R+ E
Sbjct: 352 EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQA 411
Query: 1547 ARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXX 1606
R ++ +EL+A ++ E + + +
Sbjct: 412 ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 471
Query: 1607 XXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQ--- 1663
+Q+ A +AE+ + R G++ +R ++ + R E+ +Y +
Sbjct: 472 RHREELEQSKQAAGALRAELLRAQ-RELGELIPLRQKVAEQERTAQQLRAEKASYAEQLS 530
Query: 1664 MLEAAQKSMAEIKNG-DKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLA 1722
ML+ A +AE G + A + R + ++ V L A E L E + A
Sbjct: 531 MLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREA 590
Query: 1723 SKLNTEL---VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERD 1779
EL ++ A+V++ E + R E E ++L A+V L+ ++ + +
Sbjct: 591 QSTARELEVMTAKYEGAKVKVLEERQRFQE-ERQKL----TAQVEELSKKLADSDQASKV 645
Query: 1780 EQQRL 1784
+QQ+L
Sbjct: 646 QQQKL 650
Score = 42.7 bits (96), Expect = 0.013
Identities = 50/175 (28%), Positives = 83/175 (47%), Gaps = 20/175 (11%)
Query: 1617 QSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRE----RDNYKQMLEAAQKSM 1672
++E+A +AE +GQ+ EL + ++ +RE R + +A +
Sbjct: 243 EAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWK 302
Query: 1673 AEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSE 1732
A++ G + A +NS+ S+ EEE V++L +QV LE E ES+ L + E SE
Sbjct: 303 AQVARGRQEAE-RKNSLISSLEEE----VSILNRQV--LEKE-GESKELKRLVMAE--SE 352
Query: 1733 KSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQE 1787
KS +++ RL + E +S RA A R E+ +E E+QR+ E
Sbjct: 353 KSQ------KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASE 401
Score = 37.9 bits (84), Expect = 0.37
Identities = 67/319 (21%), Positives = 122/319 (38%), Gaps = 26/319 (8%)
Query: 1233 LQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYD 1292
LQ + +F TL+ + + E K L + IK+LE+ LRQT +
Sbjct: 126 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE-LRQTVKQLKE 184
Query: 1293 EATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAK- 1351
+ E + E K++ + E + + Q ++D +
Sbjct: 185 QLAKK----EKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLER 240
Query: 1352 -LENXXXXXXXXXXXXXXXSSYWENKAKEL---DTDLQSERKKLDRMRIAHDKDVKNKDA 1407
LE E KA+EL + L S +++L R K +D
Sbjct: 241 SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 300
Query: 1408 ELATL-KGKLKILEQNSGAGA--KRITELKQ---EYEETVKKLEHSLALEKAEYEELTGK 1461
A + +G+ + +NS + + ++ L + E E K+L+ + E + ++L +
Sbjct: 301 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER 360
Query: 1462 YELLEEEHVVTKARLTV------EKEQAQGELLHVQKELSTALGEIKTLQ----EKLGTE 1511
LL+ E AR E+ Q+ E Q+ S L + T Q E+LG E
Sbjct: 361 LRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 420
Query: 1512 SAAWNTEKTEMQNSIASLQ 1530
AW + + + ++++LQ
Sbjct: 421 LKAWQEKFFQKEQALSTLQ 439
Score = 35.5 bits (78), Expect = 2.0
Identities = 77/397 (19%), Positives = 147/397 (37%), Gaps = 32/397 (8%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E RK L+ +S E+E SI + +SKE ++ + E+S ++ L+Q +
Sbjct: 311 EAERKNSLI---SSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAE 367
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
+ NS + + ++ E L QE+ +++
Sbjct: 368 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK 427
Query: 287 CERVEKEKSDILLRRLANIDTANKYTTGRS-SEVLKLQQKVNELTTHNEDLRDEKKHLTQ 345
+ E+ S + L + ++ + + L+ +Q E H E+L K Q
Sbjct: 428 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE-KRHREELEQSK----Q 482
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
+ +EL + + ++ LR K+ E ++L E ++L L +
Sbjct: 483 AAGALRAEL---LRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLL 539
Query: 406 QDNFREDQADEYSSLRRE-LEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG 464
+ R E ++L R+ LE + R E+ +L +A+ E +L E+
Sbjct: 540 AEENR--GLGERANLGRQFLEVELDQAR---------EKYVQELAAVRADAETRLAEVQR 588
Query: 465 GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK--VPQPETVKVS 522
RE + + E A+ L ++ E K T L K + KV
Sbjct: 589 EAQSTARELEVMTAKYEGAKVK--VLEERQRFQEERQKLTAQVEELSKKLADSDQASKVQ 646
Query: 523 RSSL----TRGGSQEDPAQLLRDLQDSLEREADLREQ 555
+ L +GG + AQ L+ + L+ + +EQ
Sbjct: 647 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 683
>AL139421-4|CAI22511.1| 720|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 720
Score = 67.7 bits (158), Expect = 4e-10
Identities = 110/510 (21%), Positives = 220/510 (43%), Gaps = 50/510 (9%)
Query: 638 YLSIFNHMAANNLRKTAARVEEDNESLLLQLK-KMATK-ARSRKLSPTPPANKLSIETAN 695
YLS + + +N E N+ ++ +L+ K+A K A +KL AN+LS
Sbjct: 134 YLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLIT 193
Query: 696 DNDEKETDEADPAEMKLLLELNEQEATVLRRKV----EELEQDKEALKKQVKELTSKISS 751
ND +E+ + E + + Q +V + ++ E++++ L ++EL +K+
Sbjct: 194 CNDSQESSKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQ 253
Query: 752 VTKTSAGSNTTARRSLTTNSNKLAEERV-------KVLEDEIDEVRKKLIEKERDCE-RL 803
+ + S+ + T+ +L +E + LE E+ + +L+ E+ E ++
Sbjct: 254 IE--AENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKI 311
Query: 804 HAELSLAQKKPKT---LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK 860
A S+A K + L+ L+ DQQ + ++ + +++Q+ + +SL+ +
Sbjct: 312 VAYSSIAAKNAELEQELMLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLD----R 367
Query: 861 LQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKV 920
L TE+K +N K + KAL + T +L AL KE ++ ++ K
Sbjct: 368 LLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKE 427
Query: 921 RFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK-------------DD 967
+F + KK+++ + Q Q TL+ + +D
Sbjct: 428 KFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELED 487
Query: 968 AQKSFKPRIPKKPTDLTTKLQ-----LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
Q + ++ K +L + + L+KM E +CE +K + TA+ +
Sbjct: 488 TQTKLEKQVSKLEQELQKQRESSAEKLRKMEE--KCESAAHEADLKRQKVIELTGTAR-Q 544
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
++ E+D+ + +LSK + E + K + + L ++ L+ K K A++ E
Sbjct: 545 VKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVK-ELEK 603
Query: 1083 LSNQCKT-LTEEMKNREAQINKLSADLKNA 1111
L + +T LTE ++ RE L +L+NA
Sbjct: 604 LQHSTETELTEALQKREV----LETELQNA 629
Score = 52.0 bits (119), Expect = 2e-05
Identities = 87/402 (21%), Positives = 164/402 (40%), Gaps = 40/402 (9%)
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
LE +Q+ + + L+QD + ++ L ++ N +L N+
Sbjct: 334 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 393
Query: 774 LAEERVKV--LEDEIDEVRKKLI----------EK-ERDCERLHAELSLAQKKPKTLIKS 820
++EE +KV L+ ++ +++L+ EK E+ ++ E+ QK+ K IK+
Sbjct: 394 VSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELK--IKN 451
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAKSLRS 879
SL + +QNV L+ LQ +Q + LE KL+ + KL Q L+ + +
Sbjct: 452 HSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSA 511
Query: 880 DKALDLNTK-KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
+K + K ++ E +LK K+ EL + K E E +K E + + K+
Sbjct: 512 EKLRKMEEKCESAAHEADLKR--QKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 569
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE-DLE 997
K K +A K + T+LT LQ ++++E +L+
Sbjct: 570 GENKAMHLSQLDMILDQTKTELEK--KTNAVKELEKLQHSTETELTEALQKREVLETELQ 627
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
GE+ K+ L +++ E+R L K + ++ A+L++
Sbjct: 628 NAHGEL----------------KSTL-RQLQELRDVLQKAQLSLEEKYTTIKDLTAELRE 670
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTE-EMKNRE 1098
++E K +AL+ N L + +T +M RE
Sbjct: 671 CKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIRE 712
Score = 48.8 bits (111), Expect = 2e-04
Identities = 74/320 (23%), Positives = 144/320 (45%), Gaps = 22/320 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKLQ 323
K+Y+ + + L ++ LR + ++E E SD+ + R + + ++S KL+
Sbjct: 231 KQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE 290
Query: 324 ----QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAE 378
+K ++L T + L +EK I +ELE EAQ ++ +Q + +
Sbjct: 291 SEMTKKCSQLLTLEKQL-EEKIVAYSSIAAKNAELEQELMLEAQLEKKDQQFKEQEKTMS 349
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXM-QDNFREDQADEYSSLRREL-EQTIKNCRVLS- 435
L ++++ + ++ R L M ++N ++D+A +L+ ++ E+TIK ++ S
Sbjct: 350 MLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEA--LKALQNQVSEETIKVRQLDSA 407
Query: 436 FKLKKTE--RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELE-QEVARSTEVALRL 492
++ K E +QLE K + EK+L + +Q+E +IK QE + +
Sbjct: 408 LEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHT 467
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE---RE 549
++ + + T N L +VS+ +E A+ LR +++ E E
Sbjct: 468 LQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHE 527
Query: 550 ADLREQLRNAEEETANCKQV 569
ADL+ Q E T +QV
Sbjct: 528 ADLKRQ--KVIELTGTARQV 545
Score = 42.3 bits (95), Expect = 0.017
Identities = 54/305 (17%), Positives = 128/305 (41%), Gaps = 8/305 (2%)
Query: 1260 NKITSLESTIAAKDVH-IKQLEDALRQTTNDKYDEATSPVE--MVEMRXXXXXXXXXXXX 1316
+K++SLE+ H ++ ++D + T N +Y++ + + E+R
Sbjct: 201 SKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSD 260
Query: 1317 XQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENK 1376
+ + + + + + E ++L+S++ K + S K
Sbjct: 261 LKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAK 320
Query: 1377 AKELDTDL--QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELK 1434
EL+ +L +++ +K D+ +K + ++ + L+ L++ + +
Sbjct: 321 NAELEQELMLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKEN 380
Query: 1435 QEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
+ +E +K L++ ++ E + +L E+ +EE V+ +L KE+ + +L +E+
Sbjct: 381 MKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 440
Query: 1495 STALGEIKTLQEKLGTESAAWNT--EKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
E+K L E++ N + T Q QE + G E + +L ++ +
Sbjct: 441 YCLQKELKIKNHSL-QETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKL 499
Query: 1553 ERELR 1557
E+EL+
Sbjct: 500 EQELQ 504
Score = 41.1 bits (92), Expect = 0.039
Identities = 138/727 (18%), Positives = 282/727 (38%), Gaps = 84/727 (11%)
Query: 650 LRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANK-LSIETANDN-DEKETDEA-- 705
L++ +++E+N + +L+ MA K T L +E+ +N DE D+
Sbjct: 21 LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSL 80
Query: 706 --DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
+ E+K+ + + + ++++E + +L+K + +L K + + +
Sbjct: 81 MNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK----RELFGFKSYLS 136
Query: 764 RRSLTTNSNKLAEER-VKVLEDE---IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK 819
+ +++ SNK E+R + E I E+R KL KE + ++LHA L+ Q +
Sbjct: 137 KYQMSSFSNK--EDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITC 194
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS 879
+ S ++S +++ + Q SV K Q+ N+ Q E ++ +L+ + LR+
Sbjct: 195 NDSQESSKLSSLETEPVKLGGHQVESV---KDQNQHTMNK--QYEKERQRLVTGIEELRT 249
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXX 939
K + + + ++LK +A + Q+E EK + ++K E++ K
Sbjct: 250 -KLIQIEAE-----NSDLKVNMAHRTSQFQLIQEELLEKA---SNSSKLESEMTKK---C 297
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
K+ + + + + ++ KK D K Q K M
Sbjct: 298 SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMLEAQLEKK--DQQFKEQEKTM------S 349
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+ + ++ K L + L + E++ + K D +N++ E K++ ++
Sbjct: 350 MLQQDIICKQHHLESLDRL----LTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLD 405
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
+ LE K+ LE Q K +EE+ + ++ +KN SLQ T
Sbjct: 406 SALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELK-----IKN-HSLQETSE 459
Query: 1120 DCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXX 1179
+ D TK+++ +KL +E+ K+
Sbjct: 460 QNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQEL---QKQRESSAEKLRK 516
Query: 1180 XXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK 1239
C+ + ++ +V + L T R++ IE+ K+EL ++
Sbjct: 517 MEEKCESAAHEADLKRQKV--------------IELTGTARQVKIEMDQYKEELSK--ME 560
Query: 1240 TESKFITLEAEMRDLKADYENKITSLESTIAAKDVH-IKQLEDALRQTTNDKYDEATSPV 1298
E + + E + + + I T K + +K+LE L+ +T + EA
Sbjct: 561 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELE-KLQHSTETELTEALQKR 619
Query: 1299 EMVEMRXXXXXXXXXXXXXQ-----DELNNAKIKLEK-------TEAESSAAKLEMAQLK 1346
E++E Q D L A++ LE+ AE K+E+ K
Sbjct: 620 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 679
Query: 1347 SDLAKLE 1353
+L +++
Sbjct: 680 QELLEMD 686
Score = 40.7 bits (91), Expect = 0.052
Identities = 96/576 (16%), Positives = 211/576 (36%), Gaps = 19/576 (3%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
E LQ R +S+ L+ ++R LK + N L + QL ++ RQ+
Sbjct: 3 ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTES-RQSIL 61
Query: 1289 DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
E + E++ + + N ++ L + E ESS ++E+ L+
Sbjct: 62 KLESELENKDEILRDKFSLMNENRELKV-RVAAQNERLDLCQQEIESS--RVELRSLEKI 118
Query: 1349 LAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIA---HDKDVKNK 1405
+++L S + NK ++ + + +RI + +++
Sbjct: 119 ISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKL 178
Query: 1406 DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELL 1465
A L + ++ N + +++ L+ E VK H + K + + K
Sbjct: 179 HANLTANQLSQSLITCNDSQESSKLSSLETE---PVKLGGHQVESVKDQNQHTMNKQYEK 235
Query: 1466 EEEHVVTKAR-LTVEKEQAQGELLHVQKELSTALGEIKTLQEKL---GTESAAWNTEKTE 1521
E + +VT L + Q + E ++ ++ + + +QE+L + S+ +E T+
Sbjct: 236 ERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTK 295
Query: 1522 MQNSIASLQERLCGGGWEVER-ARLNARLDQRERELRAANDRRDV-LEHHHDXXXXXXXX 1579
+ + +L+++L A NA L+Q E L A +++D +
Sbjct: 296 KCSQLLTLEKQLEEKIVAYSSIAAKNAELEQ-ELMLEAQLEKKDQQFKEQEKTMSMLQQD 354
Query: 1580 XXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNT 1639
E + ++ ++ ++ + E
Sbjct: 355 IICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEE 414
Query: 1640 MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRN 1699
+ L L +F ++ + + QK + +IKN +N I ++ +
Sbjct: 415 LVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL-KIKNHSLQETSEQNVILQHTLQQQQQ 473
Query: 1700 KVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSG 1759
+ + LED + SKL EL ++ S+ +L +M+ + E L
Sbjct: 474 MLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQ 533
Query: 1760 RA-RVAGLATRMELAWHKERDEQQRLLQETSTLARD 1794
+ + G A ++++ + ++E ++ +E L RD
Sbjct: 534 KVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 569
Score = 35.9 bits (79), Expect = 1.5
Identities = 30/114 (26%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL---TVEKEQAQGELLHVQKEL 1494
E+ K+L+ L K+E E L K L+EE+ K +L V+ + +L ++ +
Sbjct: 1 EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI 60
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR 1548
E++ E L + + N E E++ +A+ ERL E+E +R+ R
Sbjct: 61 LKLESELENKDEILRDKFSLMN-ENRELKVRVAAQNERLDLCQQEIESSRVELR 113
Score = 35.5 bits (78), Expect = 2.0
Identities = 98/476 (20%), Positives = 196/476 (41%), Gaps = 60/476 (12%)
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAAET 379
+L+ K+ ++ N DL+ H T + + I+ EL + S ++ ++ + ++LL E
Sbjct: 246 ELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK 305
Query: 380 LCEE-------LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE-------LE 425
EE + +N ++++EL L F+E Q S L+++ LE
Sbjct: 306 QLEEKIVAYSSIAAKNAELEQELM-LEAQLEKKDQQFKE-QEKTMSMLQQDIICKQHHLE 363
Query: 426 QTIKNCRVLSFKLKKTERKADQ----LEQEKAEHEKKLLEIVGGPDGMQRE-----NRI- 475
+ ++KK K D+ L+ + +E K+ ++ + + E N++
Sbjct: 364 SLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLE 423
Query: 476 ---KELEQEVARSTEVALRLQRELAEANSKF--TGSNPSLMKVPQPETVKVSRSSLTRGG 530
++ E+++ + +E LQ+EL N T +++ + ++ + R G
Sbjct: 424 GNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNG 483
Query: 531 SQEDPAQLLRDLQDSLEREADLR-----EQLRNAEEETANCKQVNPPTFLDKQVM----- 580
ED L LE+E + E+LR EE+ C+ L +Q +
Sbjct: 484 ELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEK---CESAAHEADLKRQKVIELTG 540
Query: 581 TDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP-PLSIDKTTEETQFHFD-LPY 638
T V ++ + + + ++ +++H +K S + +D+T E + + +
Sbjct: 541 TARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKE 600
Query: 639 LSIFNHMAANNLRKTAARVEE-DNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDN 697
L H L + + E + E + +T + ++L +LS+E
Sbjct: 601 LEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE----- 655
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT 753
EK T D L EL E + + +K E LE D +ALK++ EL + + VT
Sbjct: 656 -EKYTTIKD-----LTAELRECKMEIEDKKQELLEMD-QALKERNWELKQRAAQVT 704
Score = 35.1 bits (77), Expect = 2.6
Identities = 77/461 (16%), Positives = 167/461 (36%), Gaps = 32/461 (6%)
Query: 1217 NTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHI 1276
N H ++ + E+ L + +K I +EAE DLK + ++ TS I + +
Sbjct: 225 NQHT-MNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHR-TSQFQLIQEELLEK 282
Query: 1277 KQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESS 1336
L K + + + +E + ++ + +LEK + +
Sbjct: 283 ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMLEAQLEKKDQQFK 342
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
+ M+ L+ D+ ++ + E +++ E K D
Sbjct: 343 EQEKTMSMLQQDIICKQHHLESL--------------DRLLTESKGEMKKENMKKDEALK 388
Query: 1397 AHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
A V + ++ L L+I ++ ++ K+++E+ +KK + + E +
Sbjct: 389 ALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELK 448
Query: 1457 ELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWN 1516
+ E++V+ + L +++ Q E + GE++ Q KL E
Sbjct: 449 IKNHSLQETSEQNVILQHTLQQQQQMLQQETIR--------NGELEDTQTKL--EKQVSK 498
Query: 1517 TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDV---LEHHHDXX 1573
E+ E+Q S E+L + E A A L +R++ + R V ++ + +
Sbjct: 499 LEQ-ELQKQRESSAEKLRKMEEKCESAAHEADL-KRQKVIELTGTARQVKIEMDQYKEEL 556
Query: 1574 XXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRY 1633
D E + +++ EK + + T+ T
Sbjct: 557 SKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETEL-TEA 615
Query: 1634 EGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAE 1674
+ + EL++ H ++ R+ + +L+ AQ S+ E
Sbjct: 616 LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE 656
Score = 34.3 bits (75), Expect = 4.5
Identities = 30/132 (22%), Positives = 59/132 (44%), Gaps = 5/132 (3%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ + +++ K+E+ + K ++++ + + L+ +D T +E+ K V
Sbjct: 543 RQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMH-LSQLDMILDQT---KTELEKKTNAV 598
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELM 385
EL E QK +E+EL+ T RQ+++LR L A+ EE
Sbjct: 599 KELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKY 658
Query: 386 DENEDMKKELRD 397
+D+ ELR+
Sbjct: 659 TTIKDLTAELRE 670
>AL139421-3|CAI22510.1| 1044|Homo sapiens coiled-coil domain
containing 18 protein.
Length = 1044
Score = 67.7 bits (158), Expect = 4e-10
Identities = 180/861 (20%), Positives = 349/861 (40%), Gaps = 78/861 (9%)
Query: 285 KRCERVEKEKSDILLRRLANIDTANKYTTGR----SSEVLKLQQKVNELTTHNEDLRDEK 340
++ E+V+ E+ +IL R L N + NK R SE+ L++K+ +L N + +++
Sbjct: 6 EKLEKVQAEE-EILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKL 64
Query: 341 KHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLX 399
+ + K E+ ++L E+R S ++E + ++L + LM+EN ++K +
Sbjct: 65 RIMAVKNSEVMAQLTESRQSILKLESELEN-KDEILRDKF---SLMNENRELKVRVAAQN 120
Query: 400 XXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK--LKKTERKADQLEQEKAEHEK 457
Q + E SL + + Q + FK L K + + ++++
Sbjct: 121 ERLDLCQQEIESSRV-ELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC 179
Query: 458 KLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPE 517
+ ++V ++ + IKE E + + A +L + L N S S ++ E
Sbjct: 180 EANKLVISE--LRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLET---E 234
Query: 518 TVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDK 577
VK+ + S +D Q + Q ER+ + EE Q+ K
Sbjct: 235 PVKLGGHQVAE--SVKDQNQHTMNKQYEKERQ----RLVTGIEELRTKLIQIEAENSDLK 288
Query: 578 QVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLP 637
M + + + + K +++ S K S L+++K EE
Sbjct: 289 VNMAHRT-----SQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEK------- 336
Query: 638 YLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDN 697
+ ++ +AA N + + E NE + + T+ L+ A K+ +E +
Sbjct: 337 -IVAYSSIAAKNA-ELEQELMEKNEKIRSLETNINTEHEKICLA-FEKAKKIHLEQHKEM 393
Query: 698 DEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSA 757
EK+ + + K + EQE T+ L+QD + ++ L ++
Sbjct: 394 -EKQIERLEAQLEKKDQQFKEQEKTM-----SMLQQDIICKQHHLESLDRLLTESKGEMK 447
Query: 758 GSNTTARRSLTTNSNKLAEERVKV--LEDEIDEVRKKLI----------EK-ERDCERLH 804
N +L N+++EE +KV L+ ++ +++L+ EK E+ ++
Sbjct: 448 KENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKS 507
Query: 805 AELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE 864
E+ QK+ K IK+ SL + +QNV L+ LQ +Q + LE KL+ +
Sbjct: 508 EEVYCLQKELK--IKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ 565
Query: 865 NKKL-QLLKNAKSLRSDKALDLNTK-KTTQLENELKEALAKIKELEMICQDEKSEKKVRF 922
KL Q L+ + ++K + K ++ E +LK K+ EL + K E
Sbjct: 566 VSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR--QKVIELTGTARQVKIEMDQYK 623
Query: 923 TEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTD 982
E +K E + + K+ K K +A K + T+
Sbjct: 624 EELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEK--KTNAVKELEKLQHSTETE 681
Query: 983 LTTKLQLKKMVE-DLECEIGEMYVVMKN-AGLSGKEMTAKTKLEKE---IDEIRSKLSKN 1037
LT LQ ++++E +L+ GE+ ++ L A+ LE++ I ++ ++L +
Sbjct: 682 LTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELREC 741
Query: 1038 DSEFTNEKNRLQTEIAKLKDVNAKLE------GDKDVFANKYKA-LENENSNLSNQCKTL 1090
E ++K L LK+ N +L+ D+ +++ +E + L +
Sbjct: 742 KMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKS 801
Query: 1091 TEEMKNREAQINKLSADLKNA 1111
E+K QI L+ L+NA
Sbjct: 802 ELELKECNKQIESLNDKLQNA 822
Score = 65.7 bits (153), Expect = 2e-09
Identities = 120/668 (17%), Positives = 295/668 (44%), Gaps = 58/668 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
K+Y+ + + L ++ LR + ++E E SD+ ++ A+ R+S+ +Q+++
Sbjct: 257 KQYEKERQRLVTGIEELRTKLIQIEAENSDL------KVNMAH-----RTSQFQLIQEEL 305
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
E +++ L E ++ +E +LE + + AK E +ELM+
Sbjct: 306 LEKASNSSKLESEMTKKCSQLLTLEKQLEEK------IVAYSSIAAKNAELE---QELME 356
Query: 387 ENEDMKKELRDLXXXXXXM---QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+NE ++ ++ + + ++ +++ + +++E+ + K+ E+
Sbjct: 357 KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEK 416
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
L+Q+ + L + D + E++ E+++E + E LQ +++E K
Sbjct: 417 TMSMLQQDIICKQHHLESL----DRLLTESK-GEMKKENMKKDEALKALQNQVSEETIKV 471
Query: 504 TGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEET 563
+ S +++ + E V + G ++ QL + ++ + +L+ + ++ +ET
Sbjct: 472 RQLD-SALEICKEEL--VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK-NHSLQET 527
Query: 564 ANCKQVNPPTFLDKQVM--TDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
+ + T +Q M + I ++ +++T +K+ +E S
Sbjct: 528 SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKL--EQELQKQRESSAEKLR 585
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+++ E DL + L TA +V+ + + +L KM + K
Sbjct: 586 KMEEKCESAAHEADLKRQKVI------ELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 639
Query: 682 PTPPANKLS-IETANDNDEKETDEADPA--EMKLLLELNEQEATVLRRKVEELEQDKEAL 738
A LS ++ D + E ++ A E++ L E E T +K E LE + +
Sbjct: 640 GENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNA 699
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
++K ++ + + + TT + AE ++ + EI++ +++L+E ++
Sbjct: 700 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAE--LRECKMEIEDKKQELLEMDQ 757
Query: 799 DCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADN 858
+ + EL + + LD + +++ Q ++I+ E ++ +++ + L+ N
Sbjct: 758 ALKERNWELK------QRAAQVTHLDMTIREHRGEMEQ-KIIKLEGTLEKSELE-LKECN 809
Query: 859 EKLQTENKKLQLLKNAKSLRSDKALDL-NTKKTTQLENELKEALAKIKELEMICQDEKSE 917
+++++ N KLQ K + LR + + L N ++ +QL+ E++ ++KE+E + ++++
Sbjct: 810 KQIESLNDKLQNAK--EQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQY 867
Query: 918 KKVRFTEA 925
++ EA
Sbjct: 868 IATQYKEA 875
Score = 65.3 bits (152), Expect = 2e-09
Identities = 175/958 (18%), Positives = 380/958 (39%), Gaps = 91/958 (9%)
Query: 650 LRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANK-LSIETANDN-DEKETDEA-- 705
L++ +++E+N + +L+ MA K T L +E+ +N DE D+
Sbjct: 46 LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSL 105
Query: 706 --DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
+ E+K+ + + + ++++E + +L+K + +L K + + +
Sbjct: 106 MNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK----RELFGFKSYLS 161
Query: 764 RRSLTTNSNKLAEER-VKVLEDE---IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK 819
+ +++ SNK E+R + E I E+R KL KE + ++LHA L+ Q +
Sbjct: 162 KYQMSSFSNK--EDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITC 219
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ-----SLEADNEKLQTENKKLQL-LKN 873
+ S ++S +++ + Q A ++ + Q E + ++L T ++L+ L
Sbjct: 220 NDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQ 279
Query: 874 AKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTL 933
++ SD +++ +T+Q + +E L K + + E ++K + K+ + +
Sbjct: 280 IEAENSDLKVNM-AHRTSQFQLIQEELLEKASNSSKL-ESEMTKKCSQLLTLEKQLEEKI 337
Query: 934 KSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMV 993
+ ++ ++ + +K K L +++K +
Sbjct: 338 VAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQI 397
Query: 994 EDLECEI----GEMYVVMKNAGLSGKEMTAKTKLEKEID--------EIRSKLSKNDSEF 1041
E LE ++ + K + +++ K + +D E++ + K D
Sbjct: 398 ERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 457
Query: 1042 TNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQI 1101
+N++ E K++ +++ LE K+ LE Q K +EE+ + ++
Sbjct: 458 KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 517
Query: 1102 NKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLK 1161
+KN SLQ T + D TK+++ +KL +
Sbjct: 518 K-----IKN-HSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQ 571
Query: 1162 EVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRR 1221
E+ K+ C+ + ++ +V + L T R+
Sbjct: 572 EL---QKQRESSAEKLRKMEEKCESAAHEADLKRQKV--------------IELTGTARQ 614
Query: 1222 LSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVH-IKQLE 1280
+ IE+ K+EL ++ E + + E + + + I T K + +K+LE
Sbjct: 615 VKIEMDQYKEELSK--MEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELE 672
Query: 1281 DALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ-----DELNNAKIKLEK----- 1330
L+ +T + EA E++E Q D L A++ LE+
Sbjct: 673 -KLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTI 731
Query: 1331 --TEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
AE K+E+ K +L +++ ++ + +E +++ +
Sbjct: 732 KDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKI 791
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSG-------AGAKRITELKQEYEETV 1441
KL+ + ++K + ++ +L KL+ ++ + I++LK+E E T
Sbjct: 792 IKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQ 851
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQ-AQGELLHVQKELSTALGE 1500
++++ ++ K + + + +Y+ E + + RLT E+ Q + EL + + A E
Sbjct: 852 QRMKEMESVMKEQEQYIATQYK--EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQRE 909
Query: 1501 IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
I+ L +L + + EK N +A E L G +V A L AR+ ++L A
Sbjct: 910 IERLSSEL-EDMKQLSKEKDAHGNHLA---EEL--GASKVREAHLEARMQAEIKKLSA 961
Score = 61.3 bits (142), Expect = 3e-08
Identities = 129/663 (19%), Positives = 279/663 (42%), Gaps = 61/663 (9%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKS----DILLRRLANIDTANKYTTGRSSEVLKL 322
KE + QIE L+ +++ ++ + EK S DI+ ++ ++++ ++ T E+ K
Sbjct: 391 KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQ-HHLESLDRLLTESKGEMKKE 449
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCE 382
K +E + L+++ T K+R+++S LE E + QL E +
Sbjct: 450 NMKKDEAL---KALQNQVSEETIKVRQLDSALEI--CKEELVLHLNQLEGN---KEKFEK 501
Query: 383 ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL---EQTIKNCRV--LSFK 437
+L ++E++ ++L +Q+ ++ +++ +++ ++TI+N + K
Sbjct: 502 QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK 561
Query: 438 LKKTERKADQ-LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
L+K K +Q L++++ +KL ++ + E +K Q+V T A +++ E+
Sbjct: 562 LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR--QKVIELTGTARQVKIEM 619
Query: 497 AEANSKFTGSNPSLMKVPQP-ETVKVSRSSL--------TRGGSQEDPAQLLRDLQDSLE 547
+ + + +M + + E + S L T + + + L LQ S E
Sbjct: 620 DQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTE 679
Query: 548 READLREQLRNA-EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHA 606
E Q R E E N T Q + D + + E T +I++
Sbjct: 680 TELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYT-TIKDLTAEL 738
Query: 607 ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
E L +D+ +E + + +L T + E ++
Sbjct: 739 RECKMEIEDKKQELLEMDQALKERNWELKQRAAQV------THLDMTIREHRGEMEQKII 792
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
+L+ K+ NK IE+ ND + ++ E + ++ NEQE + L++
Sbjct: 793 KLEGTLEKSELE----LKECNK-QIESLNDKLQNAKEQL--REKEFIMLQNEQEISQLKK 845
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
++E +Q + ++ +KE I++ K + R L E+V+ E+
Sbjct: 846 EIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELR---------LTREQVQNSHTEL 896
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
E R + ++ +R+ ERL +EL + K L K + + +++ EA
Sbjct: 897 AEARHQQVQAQREIERLSSEL----EDMKQLSKEKDAHGNHLAEELGASKVREAHLEAR- 951
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK-ALDLNTKKTTQLENELKEALAKIK 905
++A+ + L A+ E L+ E ++++ + ++ K + D QL +L++A +++
Sbjct: 952 MQAEIKKLSAEVESLK-EAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELE 1010
Query: 906 ELE 908
E +
Sbjct: 1011 EAQ 1013
Score = 39.5 bits (88), Expect = 0.12
Identities = 63/394 (15%), Positives = 147/394 (37%), Gaps = 18/394 (4%)
Query: 1418 ILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL-------TGKYELLEEE-- 1468
+ +QN K+ + +Q +++L L +AE +L T +++L++EE
Sbjct: 247 VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL 306
Query: 1469 -HVVTKARLTVEKEQAQGELLHVQKELS---TALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
++L E + +LL ++K+L A I +L E N + ++
Sbjct: 307 EKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLET 366
Query: 1525 SIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDV-LEHHHDXXXXXXXXXX 1581
+I + E++C + ++ L + ++++ L A +++D +
Sbjct: 367 NINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDII 426
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
E + ++ ++ ++ + E +
Sbjct: 427 CKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELV 486
Query: 1642 DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
L L +F ++ + + QK + +IKN +N I ++ + +
Sbjct: 487 LHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL-KIKNHSLQETSEQNVILQHTLQQQQQML 545
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRA 1761
+ LED + SKL EL ++ S+ +L +M+ + E L +
Sbjct: 546 QQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKV 605
Query: 1762 -RVAGLATRMELAWHKERDEQQRLLQETSTLARD 1794
+ G A ++++ + ++E ++ +E L RD
Sbjct: 606 IELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 639
Score = 35.9 bits (79), Expect = 1.5
Identities = 30/114 (26%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL---TVEKEQAQGELLHVQKEL 1494
E+ K+L+ L K+E E L K L+EE+ K +L V+ + +L ++ +
Sbjct: 26 EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI 85
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR 1548
E++ E L + + N E E++ +A+ ERL E+E +R+ R
Sbjct: 86 LKLESELENKDEILRDKFSLMN-ENRELKVRVAAQNERLDLCQQEIESSRVELR 138
>BX538286-1|CAD98081.1| 724|Homo sapiens hypothetical protein
protein.
Length = 724
Score = 67.3 bits (157), Expect = 5e-10
Identities = 110/511 (21%), Positives = 221/511 (43%), Gaps = 51/511 (9%)
Query: 638 YLSIFNHMAANNLRKTAARVEEDNESLLLQLK-KMATK-ARSRKLSPTPPANKLSIETAN 695
YLS + + +N E N+ ++ +L+ K+A K A +KL AN+LS
Sbjct: 134 YLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLIT 193
Query: 696 DNDEKETDEADPAEMKLLLELNEQEATVLRRKVE-----ELEQDKEALKKQVKELTSKIS 750
ND +E+ + E + + Q A ++ + + + E++++ L ++EL +K+
Sbjct: 194 CNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQGLVTGIEELRTKLI 253
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERV-------KVLEDEIDEVRKKLIEKERDCE-R 802
+ + S+ + T+ +L +E + LE E+ + +L+ E+ E +
Sbjct: 254 QIE--AENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEK 311
Query: 803 LHAELSLAQKKPKT---LIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNE 859
+ A S+A K + L+ L+ DQQ + ++ + +++Q+ + +SL+
Sbjct: 312 IVAYSSIAAKNAELEQELMLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLD---- 367
Query: 860 KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK 919
+L TE+K +N K + KAL + T +L AL KE ++ ++ K
Sbjct: 368 RLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEIRKEELVLHLNQLEGNK 427
Query: 920 VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK-------------D 966
+F + KK+++ + Q Q TL+ + +
Sbjct: 428 EKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELE 487
Query: 967 DAQKSFKPRIPKKPTDLTTKLQ-----LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKT 1021
D Q + ++ K +L + + L+KM E +CE +K + TA+
Sbjct: 488 DTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE--KCESAAHEADLKRQKVIELTGTAR- 544
Query: 1022 KLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENS 1081
+++ E+D+ + +LSK + E + K + + L ++ L+ K K A++ E
Sbjct: 545 QVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVK-ELE 603
Query: 1082 NLSNQCKT-LTEEMKNREAQINKLSADLKNA 1111
L + +T LTE ++ RE L +L+NA
Sbjct: 604 KLQHSTETELTEALQKREV----LETELQNA 630
Score = 54.0 bits (124), Expect = 5e-06
Identities = 75/320 (23%), Positives = 146/320 (45%), Gaps = 22/320 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKLQ 323
K+Y+ + +GL ++ LR + ++E E SD+ + R + + ++S KL+
Sbjct: 232 KQYEKERQGLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE 291
Query: 324 ----QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQ-TRQIEQLRAKLLAAE 378
+K ++L T + L +EK I +ELE EAQ ++ +Q + +
Sbjct: 292 SEMTKKCSQLLTLEKQL-EEKIVAYSSIAAKNAELEQELMLEAQLEKKDQQFKEQEKTMS 350
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXM-QDNFREDQADEYSSLRREL-EQTIKNCRVLS- 435
L ++++ + ++ R L M ++N ++D+A +L+ ++ E+TIK ++ S
Sbjct: 351 MLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEA--LKALQNQVSEETIKVRQLDSA 408
Query: 436 FKLKKTE--RKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELE-QEVARSTEVALRL 492
+++K E +QLE K + EK+L + +Q+E +IK QE + +
Sbjct: 409 LEIRKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHT 468
Query: 493 QRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE---RE 549
++ + + T N L +VS+ +E A+ LR +++ E E
Sbjct: 469 LQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHE 528
Query: 550 ADLREQLRNAEEETANCKQV 569
ADL+ Q E T +QV
Sbjct: 529 ADLKRQ--KVIELTGTARQV 546
Score = 53.2 bits (122), Expect = 9e-06
Identities = 89/402 (22%), Positives = 163/402 (40%), Gaps = 40/402 (9%)
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
LE +Q+ + + L+QD + ++ L ++ N +L N+
Sbjct: 335 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 394
Query: 774 LAEERVKVLE-DEIDEVRKKLI-----------EK-ERDCERLHAELSLAQKKPKTLIKS 820
++EE +KV + D E+RK+ + EK E+ ++ E+ QK+ K IK+
Sbjct: 395 VSEETIKVRQLDSALEIRKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELK--IKN 452
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAKSLRS 879
SL + +QNV L+ LQ +Q + LE KL+ + KL Q L+ + +
Sbjct: 453 HSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSA 512
Query: 880 DKALDLNTK-KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
+K + K ++ E +LK K+ EL + K E E +K E + + K+
Sbjct: 513 EKLRKMEEKCESAAHEADLKR--QKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 570
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE-DLE 997
K K +A K + T+LT LQ ++++E +L+
Sbjct: 571 GENKAMHLSQLDMILDQTKTELEK--KTNAVKELEKLQHSTETELTEALQKREVLETELQ 628
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
GE+ K+ L +++ E+R L K + ++ A+L++
Sbjct: 629 NAHGEL----------------KSTL-RQLQELRDVLQKAQLSLEEKYTTIKDLTAELRE 671
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTE-EMKNRE 1098
++E K +AL+ N L + +T +M RE
Sbjct: 672 CKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIRE 713
Score = 41.5 bits (93), Expect = 0.030
Identities = 51/236 (21%), Positives = 101/236 (42%), Gaps = 10/236 (4%)
Query: 1326 IKLEKTEAESSAAKLEMAQLK--SDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD 1383
I+ E E S+++KLE K S L LE ++ E +EL +
Sbjct: 276 IQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELE---QELMLE 332
Query: 1384 LQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKK 1443
Q E+K D+ +K + ++ + L+ L++ + + + +E +K
Sbjct: 333 AQLEKK--DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKA 390
Query: 1444 LEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKT 1503
L++ ++ E + +L E+ +EE V+ +L KE+ + +L +E+ E+K
Sbjct: 391 LQNQVSEETIKVRQLDSALEIRKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKI 450
Query: 1504 LQEKLGTESAAWNT--EKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELR 1557
L E++ N + T Q QE + G E + +L ++ + E+EL+
Sbjct: 451 KNHSL-QETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQ 505
Score = 40.7 bits (91), Expect = 0.052
Identities = 140/764 (18%), Positives = 292/764 (38%), Gaps = 83/764 (10%)
Query: 650 LRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANK-LSIETANDN-DEKETDEA-- 705
L++ +++E+N + +L+ MA K T L +E+ +N DE D+
Sbjct: 21 LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSL 80
Query: 706 --DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
+ E+K+ + + + ++++E + +L+K + +L K + + +
Sbjct: 81 MNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK----RELFGFKSYLS 136
Query: 764 RRSLTTNSNKLAEER-VKVLEDE---IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK 819
+ +++ SNK E+R + E I E+R KL KE + ++LHA L+ Q +
Sbjct: 137 KYQMSSFSNK--EDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITC 194
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS 879
+ S ++S +++ + Q A K Q+ N+ Q E ++ L+ + LR+
Sbjct: 195 NDSQESSKLSSLETEPVKLGGHQVAE--SVKDQNQHTMNK--QYEKERQGLVTGIEELRT 250
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXX 939
K + + + ++LK +A + Q+E EK + ++K E++ K
Sbjct: 251 -KLIQIEAE-----NSDLKVNMAHRTSQFQLIQEELLEKA---SNSSKLESEMTKK---C 298
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECE 999
K+ + + + + ++ KK D K Q K M
Sbjct: 299 SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMLEAQLEKK--DQQFKEQEKTM------S 350
Query: 1000 IGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVN 1059
+ + ++ K L + L + E++ + K D +N++ E K++ ++
Sbjct: 351 MLQQDIICKQHHLESLDRL----LTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLD 406
Query: 1060 AKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMS 1119
+ LE K+ LE Q K +EE+ + ++ +KN SLQ T
Sbjct: 407 SALEIRKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELK-----IKN-HSLQETSE 460
Query: 1120 DCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXX 1179
+ D TK+++ +KL +E+ K+
Sbjct: 461 QNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQEL---QKQRESSAEKLRK 517
Query: 1180 XXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK 1239
C+ + ++ +V + L T R++ IE+ K+EL ++
Sbjct: 518 MEEKCESAAHEADLKRQKV--------------IELTGTARQVKIEMDQYKEELSK--ME 561
Query: 1240 TESKFITLEAEMRDLKADYENKITSLESTIAAKDVH-IKQLEDALRQTTNDKYDEATSPV 1298
E + + E + + + I T K + +K+LE L+ +T + EA
Sbjct: 562 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELE-KLQHSTETELTEALQKR 620
Query: 1299 EMVEMRXXXXXXXXXXXXXQ-----DELNNAKIKLEK-------TEAESSAAKLEMAQLK 1346
E++E Q D L A++ LE+ AE K+E+ K
Sbjct: 621 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 680
Query: 1347 SDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKK 1390
+L +++ ++ + +E +++ ++KK
Sbjct: 681 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKKKK 724
Score = 39.9 bits (89), Expect = 0.091
Identities = 95/577 (16%), Positives = 212/577 (36%), Gaps = 20/577 (3%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
E LQ R +S+ L+ ++R LK + N L + QL ++ RQ+
Sbjct: 3 ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTES-RQSIL 61
Query: 1289 DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSD 1348
E + E++ + + N ++ L + E ESS ++E+ L+
Sbjct: 62 KLESELENKDEILRDKFSLMNENRELKV-RVAAQNERLDLCQQEIESS--RVELRSLEKI 118
Query: 1349 LAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIA---HDKDVKNK 1405
+++L S + NK ++ + + +RI + +++
Sbjct: 119 ISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKL 178
Query: 1406 DAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLA--LEKAEYEELTGKYE 1463
A L + ++ N + +++ L+ E VK H +A ++ + +YE
Sbjct: 179 HANLTANQLSQSLITCNDSQESSKLSSLETE---PVKLGGHQVAESVKDQNQHTMNKQYE 235
Query: 1464 LLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL---GTESAAWNTEKT 1520
+ V L + Q + E ++ ++ + + +QE+L + S+ +E T
Sbjct: 236 KERQGLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMT 295
Query: 1521 EMQNSIASLQERLCGGGWEVER-ARLNARLDQRERELRAANDRRDV-LEHHHDXXXXXXX 1578
+ + + +L+++L A NA L+Q E L A +++D +
Sbjct: 296 KKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQ-ELMLEAQLEKKDQQFKEQEKTMSMLQQ 354
Query: 1579 XXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMN 1638
E + ++ ++ ++ + E +
Sbjct: 355 DIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEIRKE 414
Query: 1639 TMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYR 1698
+ L L +F ++ + + QK + +IKN +N I ++ +
Sbjct: 415 ELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL-KIKNHSLQETSEQNVILQHTLQQQQ 473
Query: 1699 NKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSS 1758
+ + LED + SKL EL ++ S+ +L +M+ + E L
Sbjct: 474 QMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR 533
Query: 1759 GRA-RVAGLATRMELAWHKERDEQQRLLQETSTLARD 1794
+ + G A ++++ + ++E ++ +E L RD
Sbjct: 534 QKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 570
Score = 35.9 bits (79), Expect = 1.5
Identities = 30/114 (26%), Positives = 54/114 (47%), Gaps = 4/114 (3%)
Query: 1438 EETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL---TVEKEQAQGELLHVQKEL 1494
E+ K+L+ L K+E E L K L+EE+ K +L V+ + +L ++ +
Sbjct: 1 EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI 60
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNAR 1548
E++ E L + + N E E++ +A+ ERL E+E +R+ R
Sbjct: 61 LKLESELENKDEILRDKFSLMN-ENRELKVRVAAQNERLDLCQQEIESSRVELR 113
Score = 34.3 bits (75), Expect = 4.5
Identities = 30/132 (22%), Positives = 59/132 (44%), Gaps = 5/132 (3%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
++ + +++ K+E+ + K ++++ + + L+ +D T +E+ K V
Sbjct: 544 RQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMH-LSQLDMILDQT---KTELEKKTNAV 599
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELM 385
EL E QK +E+EL+ T RQ+++LR L A+ EE
Sbjct: 600 KELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKY 659
Query: 386 DENEDMKKELRD 397
+D+ ELR+
Sbjct: 660 TTIKDLTAELRE 671
>BX537985-1|CAD97945.1| 1202|Homo sapiens hypothetical protein
protein.
Length = 1202
Score = 66.9 bits (156), Expect = 7e-10
Identities = 89/432 (20%), Positives = 176/432 (40%), Gaps = 37/432 (8%)
Query: 692 ETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISS 751
++ +D+ K + + +K LE+ E++ L ++EE + L++++K + +
Sbjct: 122 QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 181
Query: 752 VTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ + + + E + E+ +V+ +LIE ER+ L AE
Sbjct: 182 LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE----- 236
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLL 871
K +K++ L + QN +L+ Q+ ++++ T SL+ N LQT+N KLQ+
Sbjct: 237 ---KQALKTQ-LKQLETQNNNLQTQILALQRQ-------TVSLQEQNTTLQTQNAKLQVE 285
Query: 872 KNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
+ LN++ T+ L N+ + L + LE ++E ++ E K D
Sbjct: 286 NST----------LNSQSTS-LMNQNAQLLIQQSSLE-----NENESVIKEREDLKSLYD 329
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKK 991
+L TLKS + + + + L K QL+
Sbjct: 330 SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED 389
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTE 1051
+ + L+ E +M + KN E ++ S+L K + L++
Sbjct: 390 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 449
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTE-----EMKNREAQINKLSA 1106
+ K +LE + +Y+ L+ ++ L+NQC+ L++ E +NR +
Sbjct: 450 LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL 509
Query: 1107 DLKNATSLQTTM 1118
L+N T L+ M
Sbjct: 510 MLQNRTLLEQNM 521
Score = 58.4 bits (135), Expect = 2e-07
Identities = 83/328 (25%), Positives = 150/328 (45%), Gaps = 37/328 (11%)
Query: 261 LVDSNVK--EYQDQIEGLKQEVDILRKRCERV---EKEKSDILLRRLANIDTANKYTTGR 315
L ++NVK + + + L +E+ I ++ C R+ EKE +++ R +I T
Sbjct: 27 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 86
Query: 316 SSEVLKLQQKVNEL--TTH-------NED--LRDEKKHLTQKIREIESELETRPSTEAQT 364
SE LK QQ N+L TH N++ L DE+ + + +ES+LE ST ++
Sbjct: 87 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE---STLKKS 143
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM---QDNFREDQAD-----E 416
+I++ K+ A E EE + N+ +++EL+ + + QD R Q+ E
Sbjct: 144 LEIKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 201
Query: 417 YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIK 476
+ RE ++T + + +L + ER L+ EK + +L ++ + +Q +I
Sbjct: 202 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ--TQIL 259
Query: 477 ELEQEVARSTEVALRLQRELAE---ANSKFTGSNPSLMKVPQPETVKVSRSSL-TRGGSQ 532
L+++ E LQ + A+ NS + SLM Q + + +SSL S
Sbjct: 260 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN--QNAQLLIQQSSLENENESV 317
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAE 560
+ L+ L DSL ++ + E L +
Sbjct: 318 IKEREDLKSLYDSLIKDHEKLELLHERQ 345
Score = 53.6 bits (123), Expect = 7e-06
Identities = 74/343 (21%), Positives = 153/343 (44%), Gaps = 33/343 (9%)
Query: 772 NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTL--IKSRSLDASDQQ 829
NK ++ ++ + ++E K+ E++ + L E+ + ++ L ++ + + +
Sbjct: 13 NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRA 72
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+D+K + + E S + KTQ + D EKL E +K+ L K + L +++ D + K
Sbjct: 73 TIDIKTLVTLREDLVSE-KLKTQQMNNDLEKLTHELEKIGLNKE-RLLHDEQSTDDSRYK 130
Query: 890 --TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
++LE+ LK++L +IKE ++ + + E+ + + ++E T+K
Sbjct: 131 LLESKLESTLKKSL-EIKEEKIAALEARLEESTNYNQQLRQELKTVKKN----------- 178
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVM 1007
Q + ++ S + ++ + TT+ LK V+D E V
Sbjct: 179 ---YEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK--VKDRLIE-----VER 228
Query: 1008 KNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKD 1067
NA L ++ KT+L K+++ + L + LQ + L+ NAKL+ +
Sbjct: 229 NNATLQAEKQALKTQL-KQLETQNNNLQTQILALQRQTVSLQEQNTTLQTQNAKLQVENS 287
Query: 1068 VFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKN 1110
++ +L N+N+ L Q +L +N + K DLK+
Sbjct: 288 TLNSQSTSLMNQNAQLLIQQSSL----ENENESVIKEREDLKS 326
Score = 42.3 bits (95), Expect = 0.017
Identities = 73/339 (21%), Positives = 128/339 (37%), Gaps = 30/339 (8%)
Query: 1226 LTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALR- 1284
L E+ +R+ ESK LE+ ++ E KI +LE+ + + +QL L+
Sbjct: 118 LHDEQSTDDSRYKLLESK---LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 174
Query: 1285 -----QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAK 1339
+ + DE + EL K +L + E ++ +
Sbjct: 175 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 234
Query: 1340 LEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHD 1399
E LK+ L +LE + +E +T LQ++ KL +
Sbjct: 235 AEKQALKTQLKQLETQNNNLQTQILALQRQTV----SLQEQNTTLQTQNAKLQVENSTLN 290
Query: 1400 KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVK---KLEHSLALEKAEYE 1456
+ + A L + LE + + K +LK Y+ +K KLE + +EYE
Sbjct: 291 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 350
Query: 1457 ELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWN 1516
L K+ L+ H L VE + + K+ G+++ L++ L E
Sbjct: 351 SLISKHGTLKSAH----KNLEVEHRDLEDRYNQLLKQ----KGQLEDLEKMLKVEQEKML 402
Query: 1517 TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
E + ++A+ ++LCG E RLN Q +E
Sbjct: 403 LE-NKNHETVAAEYKKLCG-----ENDRLNHTYSQLLKE 435
>BC126266-1|AAI26267.1| 976|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 976
Score = 66.9 bits (156), Expect = 7e-10
Identities = 123/604 (20%), Positives = 253/604 (41%), Gaps = 37/604 (6%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETL 380
L + ++L E ++ K ++R+ ES+L E R EAQ + I++L+
Sbjct: 102 LSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLK 161
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
EE + EN+D+ KE +++ A++ E E+T + L+ ++K
Sbjct: 162 LEEGIQENKDLIKENNATRHLCNLLKETCAR-SAEKTKKYEYEREETRQVYMDLNNNIEK 220
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN 500
++L + +AE+ + + D + ++ +E ++E+ + L ++ E
Sbjct: 221 MITAFEEL-RVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKE 279
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAE 560
+K L + + KV++ +E +L+ S+E++ L ++L + +
Sbjct: 280 NKM----KDLTFLLEESRDKVNQ-------LEEKTKLQSENLKQSIEKQHHLTKELEDIK 328
Query: 561 EETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
D Q+ T I C + E + NK A S ++ ++
Sbjct: 329 VSLQRSVSTQKALEEDLQIATKTI--CQLTEEKETQMEESNKARAAHSFVVTEFETTVCS 386
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
L TE+ + + L I L+K ++ +EE + L K++ + + L
Sbjct: 387 LEELLRTEQQRLEKNEDQLKIL----TMELQKKSSELEEMTK--LTNNKEVELEELKKVL 440
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKL--LLELNEQEATVLRRKVEELEQDKEAL 738
K ++ N EK +E E +L LL+ E+E L ++ + ++
Sbjct: 441 -----GEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
K+VK+L +++ + K T+ L+ + +L +E + E+ ++ + ++
Sbjct: 496 SKEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQE-TSDMTLELKNQQEDINNNKK 553
Query: 799 DCERLHAELSLAQKKPKTLIKSRSL--DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
ER+ ++ Q+ L + Q+ ++K +L E+ + LR + ++
Sbjct: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
E+LQ ENK L+ A+S K L++ K +LE EL+ A K E+ Q E
Sbjct: 614 YIEELQQENKALKKKGTAES----KQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIE 669
Query: 917 EKKV 920
+KK+
Sbjct: 670 DKKI 673
Score = 62.1 bits (144), Expect = 2e-08
Identities = 85/406 (20%), Positives = 170/406 (41%), Gaps = 29/406 (7%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR-----SLTTNSNKLAEERV 779
++++ + E+ L Q+ E +K+ +T S + L + + K + E+
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
L E+++++ L + L +L +A K L + + + V
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
E E +V + + L + ++L+ +L++L +S + L+ TK T E EL+E
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSE-LEEMTKLTNNKEVELEE 435
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+ E E + + K +K+ E E + + Q Q
Sbjct: 436 LKKVLGEKETLLYENKQFEKIA-EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
K +KD + ++ K T+LT+ KL L+ ++L E +M + +KN ++
Sbjct: 495 YSKEVKDLKTELENEKL--KNTELTSHCNKLSLEN--KELTQETSDMTLELKN---QQED 547
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKYKA 1075
+ K E+ + + L + +++ NE ++ E+ + +D V KL+ ++ N K
Sbjct: 548 INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
Query: 1076 LENENS---NLSNQCKTL----TEEMKNR---EAQINKLSADLKNA 1111
+EN+N L + K L T E K E ++NKL +L++A
Sbjct: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESA 653
Score = 60.5 bits (140), Expect = 6e-08
Identities = 138/750 (18%), Positives = 296/750 (39%), Gaps = 57/750 (7%)
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L ++ E++++ K + + ++++ SK+ K A + L + K++ + + ++
Sbjct: 109 LYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQ 167
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ D +++ + C L + + +K K R + + Q +DL ++ +
Sbjct: 168 ENKDLIKENNATRHL-CNLLKETCARSAEKTKKYEYER--EETRQVYMDLNNNIEKMITA 224
Query: 844 ASVLRAKTQSLEADNE-KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA 902
LR + ++ + KL+ + +K+Q L+ K ++ K+ + L ++ E
Sbjct: 225 FEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK----KEINDKEKQVSLLLIQITEKEN 280
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
K+K+L + ++ + +K + E TK +++ LK +T K
Sbjct: 281 KMKDLTFLLEESR-DKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
+L++D Q I K T+ + +M E + +VV + T
Sbjct: 340 ALEEDLQ------IATKTICQLTEEKETQMEESNKARAAHSFVVTEFE-------TTVCS 386
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
LE+ + + +L KN+ + LQ + ++L+++ KL +K+V + K + E
Sbjct: 387 LEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT-KLTNNKEVELEELKKVLGEKET 445
Query: 1083 L---SNQCKTLTEEMKNREAQ-INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
L + Q + + EE+K E + I L A K L+ ++
Sbjct: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLT--AITTSEQYYSKEVKDLK 503
Query: 1139 XXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ N T++ NKL E + T++ D +L +++ +
Sbjct: 504 TELENEKLKN-TELTSHCNKLSLENKELTQETSDMTL--------------ELKNQQEDI 548
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
Q L T +L EL ++EL+ + + + K E +L+
Sbjct: 549 NNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV 608
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
ENK +E + ++ +K+ A + N Y+ + +E+ E+ Q
Sbjct: 609 ENKNKYIEE-LQQENKALKKKGTAESKQLN-VYEIKVNKLEL-ELESAKQKFGEITDTYQ 665
Query: 1319 DELNNAKIKLEKTEAESSAAKL---EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
E+ + KI E E AK+ E +L+ ++ K ++
Sbjct: 666 KEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDK--RCQHKIAEMVALMEKHKHQYDK 723
Query: 1376 KAKELDTDL---QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITE 1432
+E D++L +S+ ++ +R + + ++ N AEL ++K +L+I + + E
Sbjct: 724 IIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
Query: 1433 LKQEYEETVKKLEHSLALEKAE-YEELTGK 1461
+E K + LE E Y +L K
Sbjct: 784 NTATLKEKKDKKTQTFLLETPEIYWKLDSK 813
Score = 56.4 bits (130), Expect = 1e-06
Identities = 118/696 (16%), Positives = 257/696 (36%), Gaps = 46/696 (6%)
Query: 840 IEQEASVLRAKTQSLEADN---EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
+ Q+ S L+ + +EA ++LQ N+K+ L K + ++ +K L T L N
Sbjct: 127 LRQKESKLQENRKIIEAQRKAIQELQFGNEKVSL-KLEEGIQENKDLIKENNATRHLCNL 185
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
LKE A+ E + E+ E + + + + + +
Sbjct: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245
Query: 957 XQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
++ L+ + +K + +K L L + + E ++ ++ +++ + +
Sbjct: 246 DYEKIQHLEQEYKKEINDK--EKQVSL-----LLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKAL 1076
+ KTKL+ E ++ + K T E ++ + + LE D + L
Sbjct: 299 LEEKTKLQSE--NLKQSIEKQH-HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQL 355
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXX 1136
E + E K R A ++ SL+ +
Sbjct: 356 TEEKET------QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILT 409
Query: 1137 XXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKD 1196
+++ TK+ +K L+E+ K +G+ K E+ T ++
Sbjct: 410 MELQKKSSELEEMTKLTNNKEVELEEL---KKVLGEKETLLYENKQFEKIAEELKGTEQE 466
Query: 1197 RV---TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK-TE--SKFITLEAE 1250
+ Q + + + S E+ K EL+ +K TE S L E
Sbjct: 467 LIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLE 526
Query: 1251 MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
++L + + L++ + + KQ E L+Q N + E ++R
Sbjct: 527 NKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETET-------QLRNELEYV 579
Query: 1311 XXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXS 1370
+DE+ K KL+K+E + + ++ + +L+
Sbjct: 580 REELKQKRDEV---KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 1371 SYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI 1430
+ +E K +L+ +L+S ++K + + K++++K L +++ + + K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQ 696
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEEL-------TGKYELLEEEHVVTKARLTVEKEQA 1483
E+ + + + ++ + K +Y+++ G Y+ E+E +A L +E
Sbjct: 697 KEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL 756
Query: 1484 QGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
+ ELL V+K+L E + L+ + +A +K
Sbjct: 757 KAELLSVKKQLEIEREEKEKLKREAKENTATLKEKK 792
Score = 53.2 bits (122), Expect = 9e-06
Identities = 92/458 (20%), Positives = 177/458 (38%), Gaps = 35/458 (7%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEADPAEM 710
K + E + LQ + +A+ + + N K+S++ E + +
Sbjct: 120 KVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNAT 179
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ L L ++ K ++ E ++E ++ +L + I + A S
Sbjct: 180 RHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEM 239
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK--TLIKSRSLDASDQ 828
KL E+ K+ E E +K++ +KE+ L +++ + K K T + S D +Q
Sbjct: 240 HFKLKEDYEKIQHLE-QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
K Q + ++Q T+ LE LQ + L+ + + L +
Sbjct: 299 LEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEE 358
Query: 889 KTTQLENELKEALAK---IKELEM-ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K TQ+E K A + E E +C E+ + + + +K D LK
Sbjct: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ--QRLEKNEDQLK--------IL 408
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L + K+ + K + +K T L Q +K+ E+L+ E+
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
GL + A+ K +++ + ++ ++ ++ E L+TE+ K N +L
Sbjct: 469 ------GL----LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS 518
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
NK L EN L+ + +T E+KN++ IN
Sbjct: 519 H----CNK---LSLENKELTQETSDMTLELKNQQEDIN 549
Score = 51.6 bits (118), Expect = 3e-05
Identities = 120/606 (19%), Positives = 242/606 (39%), Gaps = 58/606 (9%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
E L++Q + + L H + D +K HL Q+ ++ ++ E + S QI + K+
Sbjct: 226 EELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSL--LLIQITEKENKMK 283
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
L EE D+ ++++ + L + E ++ L++++ + L
Sbjct: 284 DLTFLLEESRDKVNQLEEKTK-LQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALE 342
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
L+ + QL +EK E ++ E + E E V S E LR +++
Sbjct: 343 EDLQIATKTICQLTEEK---ETQMEE--SNKARAAHSFVVTEFETTVC-SLEELLRTEQQ 396
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD---L 552
E N ++ E ++++ + + E+ ++L + + L +
Sbjct: 397 RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKI 456
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---SIQNKMIHAAST 609
E+L+ E+E Q D ++ I T + + S+ V + ++N+ +
Sbjct: 457 AEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTEL 516
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN--------NLRKTAARVEEDN 661
S K + + T + I N+ NL++T ++ +
Sbjct: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
E + +LK+ + + + N L + N N E + + +K ++
Sbjct: 577 EYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVK 780
V KV +LE + E+ K++ E+T + + N L E E+ K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKK----------ISEENLLEEVEKAK 686
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
V+ DE +++K++ ++ C+ AE+ +K K + ++ D + K +
Sbjct: 687 VIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQY-DKIIEERDSELGLYKSK---- 738
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
EQE S LRA SLE ++ N K +LL S++ K L++ ++ +L+ E KE
Sbjct: 739 EQEQSSLRA---SLE-----IELSNLKAELL----SVK--KQLEIEREEKEKLKREAKEN 784
Query: 901 LAKIKE 906
A +KE
Sbjct: 785 TATLKE 790
Score = 48.0 bits (109), Expect = 3e-04
Identities = 63/287 (21%), Positives = 128/287 (44%), Gaps = 19/287 (6%)
Query: 278 QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLR 337
+EV L+ E EK K+ L + NK T +S++ EL ED+
Sbjct: 497 KEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQETSDMTL------ELKNQQEDIN 549
Query: 338 DEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAAETLCEELMDENEDMKKELR 396
+ KK + +++IE+ E TE Q R ++E +R +L + +D++E+ LR
Sbjct: 550 NNKKQEERMLKQIENLQE----TETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR 605
Query: 397 DLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHE 456
++ + E+ E +L+++ K V K+ K E + + +Q+ E
Sbjct: 606 ----KQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 457 KKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP 516
+ + + EN ++E+E+ + E A++LQ+E+ + +LM+ +
Sbjct: 662 DTYQKEIEDKK-ISEENLLEEVEKAKVIADE-AVKLQKEIDKRCQHKIAEMVALMEKHKH 719
Query: 517 ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLRNAEEE 562
+ K+ + G + Q L+ SLE E ++L+ +L + +++
Sbjct: 720 QYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQ 766
Score = 34.7 bits (76), Expect = 3.4
Identities = 51/309 (16%), Positives = 120/309 (38%), Gaps = 16/309 (5%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
E++E + ++ + + +L+ EN + + I+ LE ++ N
Sbjct: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
Query: 1289 DKYDEAT-SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKS 1347
DK + + +++ E +D++N + EKT+ +S K + +
Sbjct: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE---EKTKLQSENLKQSIEKQHH 319
Query: 1348 DLAKLENXXXXXXXXXXXXXXXSSYWENKAK---ELDTDLQSERKKLDRMRIAHDKDVKN 1404
+LE+ + K +L + +++ ++ ++ R AH V
Sbjct: 320 LTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTE 379
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+ + +L+ L+ +Q ++ L E ++ +LE L + EL ++
Sbjct: 380 FETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKV 439
Query: 1465 LEEEHVVTKARLTVEK--EQAQG---ELLHVQKELSTALGEIKTLQEKLGTESAAWNTE- 1518
L E+ + EK E+ +G EL+ + + + +++ + T ++ E
Sbjct: 440 LGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEV 499
Query: 1519 ---KTEMQN 1524
KTE++N
Sbjct: 500 KDLKTELEN 508
>BC027860-1|AAH27860.1| 893|Homo sapiens filamin A interacting
protein 1-like protein.
Length = 893
Score = 66.9 bits (156), Expect = 7e-10
Identities = 87/400 (21%), Positives = 179/400 (44%), Gaps = 31/400 (7%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE 777
+Q+ L R+++ELE+ +L+K +EL ++K G+ ++ E
Sbjct: 84 QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA--------EVEEL 135
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R +VL+ E + ++LI+ E C L+ L + ++S+ ++ L
Sbjct: 136 RKRVLDMEGKD--EELIKMEEQCRDLNKRLE------RETLQSKDFKLEVEKLSKRIMAL 187
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAK-SLRSDKALDLNTKKTTQLEN 895
+ +E + + + SL+ + EK + K+L Q L++ K ++ +A++ +KT E
Sbjct: 188 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT---EF 244
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK-SKQXXXXXXXXXXXXXXXXX 954
LKE L K+K L ++ DE+ +E KK D L+ +
Sbjct: 245 TLKEDLTKLKTLTVMFVDERK----TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEMYVVMKNAGLS 1013
+ LKS D +K + + K+ DL KL+ ++ DL + + +++
Sbjct: 301 EETKRALKSKTDVEEKMYS--VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 358
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K+ K KL ++ + + L + +++ ++ KLKD+ A +E D ++Y
Sbjct: 359 EKDF-LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKA-IEDDLMKTEDEY 416
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+ LE +N ++ + L++E+++ + ++ K K TS
Sbjct: 417 ETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETS 456
Score = 61.7 bits (143), Expect = 3e-08
Identities = 82/399 (20%), Positives = 176/399 (44%), Gaps = 31/399 (7%)
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L+++ EQ + +R E Q K+ K +V++L+ +I ++ K N + + + N
Sbjct: 149 LIKMEEQCRDLNKRLERETLQSKD-FKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCN 207
Query: 773 KLAEERV--KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
L +ER+ K L E++ ++ ++ E E RL + K+ T +K+ ++ D++
Sbjct: 208 -LEKERMTTKQLSQELESLKVRIKELEAIESRLE-KTEFTLKEDLTKLKTLTVMFVDERK 265
Query: 831 VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKT 890
+ +L+ E + L+A + L+ + K+ T +KL + + ++L+S ++
Sbjct: 266 T-MSEKLKKTEDK---LQAASSQLQVEQNKVTTVTEKL-IEETKRALKSKTDVEEKMYSV 320
Query: 891 TQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXX 948
T+ ++LK L +E +++ + + +++ EA +K+ K Q
Sbjct: 321 TKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQ 380
Query: 949 XXXXXXXXXQAT---------LKSLKDDAQKSFKP--RIPKKPTDLTTKLQ-LKKMVEDL 996
Q +K+++DD K+ + ++ + K Q L K +E +
Sbjct: 381 ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHV 440
Query: 997 ECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK 1056
+ E+ + + K E + + L K + E +K E K ++ +A +
Sbjct: 441 KMELAKYKLAEKT------ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT-E 493
Query: 1057 DVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
D+ L+GD V K EN N +L + + LT+E++
Sbjct: 494 DLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 532
Score = 46.8 bits (106), Expect = 8e-04
Identities = 109/539 (20%), Positives = 218/539 (40%), Gaps = 30/539 (5%)
Query: 357 RPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADE 416
R + T ++ KL AE +E + ++KEL+ QD +E
Sbjct: 17 RQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNE 76
Query: 417 YSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRE-NRI 475
S R+L+Q + +L++T R + E+E + ++K+ + G G+ E +
Sbjct: 77 -DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 135
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE-- 533
++ ++ E ++++ + + N + K + E K+S+ + ++
Sbjct: 136 RKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAF 194
Query: 534 -DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
Q L+ +LE+E +QL + E E+ + + T+ + D+ +
Sbjct: 195 NKSKQECYSLKCNLEKERMTTKQL-SQELESLKVRIKELEAIESRLEKTEFTLKEDLTKL 253
Query: 593 ETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR- 651
+T+T + T S K K L + + + + ++ + R
Sbjct: 254 KTLT----VMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN---KVTTVTEKLIEETKRA 306
Query: 652 -KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
K+ VEE S+ + + K ++ + +++++ N E E D +
Sbjct: 307 LKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNM-LKNRLQSLEAIEKDFLKN 365
Query: 711 KLLLELNEQEATVLR--RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
KL + + + + K++EL Q+ E LK ++K++ + + KT T RR
Sbjct: 366 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERR--Y 423
Query: 769 TNSNKLAEERVKVLEDEIDEVRK-KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASD 827
N A+ K LE E+ K KL EK L +++ K+ SR +DA
Sbjct: 424 ANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALK 483
Query: 828 QQNVDLKRQLQVI---EQEASVLRAKTQSLEADNEKL--QTEN--KKLQLLKN-AKSLR 878
++ + +I + + SVL+ K E N L + EN K+L+ ++ +KSLR
Sbjct: 484 EKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 542
Score = 44.4 bits (100), Expect = 0.004
Identities = 65/315 (20%), Positives = 126/315 (40%), Gaps = 13/315 (4%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+N KE ++ + V ++ R+EKE + + DT T S+ +LQ
Sbjct: 25 TNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ 84
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE----AQTRQIEQLRAKLLAAET 379
QK+ L+ ++L + + L + E++ E E ++E+LR ++L E
Sbjct: 85 QKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEG 144
Query: 380 LCEEL--MDEN-EDMKKEL--RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
EEL M+E D+ K L L ++ + L ++ + C L
Sbjct: 145 KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL 204
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQ 493
L+K QL QE + ++ E+ +++ E +KE ++ T + + +
Sbjct: 205 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 264
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
+ ++E K + Q E KV+ + + + D+++ + R
Sbjct: 265 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 324
Query: 554 EQLRN---AEEETAN 565
+ L+N AEEE N
Sbjct: 325 DDLKNKLKAEEEKGN 339
Score = 41.5 bits (93), Expect = 0.030
Identities = 93/539 (17%), Positives = 195/539 (36%), Gaps = 36/539 (6%)
Query: 1015 KEMTAKTKLEKE-IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ +TA+ L+++ I E+ + + ++ + R+Q E K + +L+ F
Sbjct: 7 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQ 66
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
+ + +N +Q + L +++ QI++L ++ + + D
Sbjct: 67 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA 126
Query: 1134 XXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQ--- 1190
+V + D++ K+ ++ D K++ +++ K+
Sbjct: 127 GIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMA 186
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTS------EKDELQARFIKTE--- 1241
L +D T ++LS EL S E + +++R KTE
Sbjct: 187 LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTL 246
Query: 1242 ----SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSP 1297
+K TL D + K+ E + A + Q+E T +K E T
Sbjct: 247 KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL-QVEQNKVTTVTEKLIEETK- 304
Query: 1298 VEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLK-SDLAKLENXX 1356
++ + +D+L N K+K E+ + +++ M + + L +E
Sbjct: 305 -RALKSKTDVEEKMYSVTKERDDLKN-KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF 362
Query: 1357 XXXXXXXXXXXXXSSYWE--NKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKG 1414
++ + NK KEL +++ + KL M+ D +K +D
Sbjct: 363 LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTED-------- 414
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVT-- 1472
+ + LE+ + L +E E +L EK E ++ L+EE +
Sbjct: 415 EYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGH 474
Query: 1473 -KARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ KE+ E + + + G+ LQ+KL + E++N L+
Sbjct: 475 LSREVDALKEKIH-EYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 532
Score = 40.3 bits (90), Expect = 0.069
Identities = 100/507 (19%), Positives = 219/507 (43%), Gaps = 56/507 (11%)
Query: 421 RRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQ 480
R+++++ N + KL E + + EQ+ EK+ L+ ++ + +L
Sbjct: 17 RQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKE-LQTQTTKFHQDQDTIMAKLTN 75
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLR 540
E +++ ++ +L L+ + +N SL K E ++ + +++G + A ++
Sbjct: 76 EDSQNRQLQQKL-AALSRQIDELEETNRSLRKA--EEELQDIKEKISKG--EYGNAGIMA 130
Query: 541 DLQDSLEREADLR---EQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
++++ +R D+ E+L EE+ C+ +N L+++ + ++ +
Sbjct: 131 EVEELRKRVLDMEGKDEELIKMEEQ---CRDLNKR--LERETLQSKDFKLEVEKLSKRIM 185
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET-QFHFDLPYLSI-FNHMAA--NNLRKT 653
+++ K+ A + SK++ S +++K T Q +L L + + A + L KT
Sbjct: 186 ALE-KLEDAFN--KSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT 242
Query: 654 AARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
++ED L +LK + + +T ++ +K D+ A +L
Sbjct: 243 EFTLKED----LTKLKTLTVMFVDER------------KTMSEKLKKTEDKLQAASSQLQ 286
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
+E N + T + K+ +E+ K ALK + ++ K+ SVTK + ++
Sbjct: 287 VEQN--KVTTVTEKL--IEETKRALKSKT-DVEEKMYSVTKERDDLKNKLKAEEEKGNDL 341
Query: 774 LA-----EERVKVLED-EIDEVRKKLIEKE-RDCERLHAE----LSLAQKKPKTLIKSRS 822
L+ + R++ LE E D ++ KL + + LH E L+Q+ + +K +
Sbjct: 342 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 401
Query: 823 LDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD-- 880
+ A + + + + + +E+ + R K Q L + E ++ E K +L + ++
Sbjct: 402 MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWL 461
Query: 881 -KALDLNTKKTTQLENELKEALAKIKE 906
K L K+ L E+ KI E
Sbjct: 462 FKRLQEEEAKSGHLSREVDALKEKIHE 488
Score = 37.1 bits (82), Expect = 0.64
Identities = 49/224 (21%), Positives = 98/224 (43%), Gaps = 21/224 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK---- 321
+++ +D KQE L+ E+ E+ + L + L ++ K S + K
Sbjct: 187 LEKLEDAFNKSKQECYSLKCNLEK-ERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 245
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L++ + +L T DE+K +++K+++ E +L+ S Q+EQ + T+
Sbjct: 246 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQ----LQVEQNKVT-----TVT 296
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+L++E + K D+ + R+D ++ + + + +L +L+
Sbjct: 297 EKLIEETKRALKSKTDVEEKMYSVTKE-RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL 355
Query: 442 ER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
E + D L+ + + K + Q N+IKEL QEV R
Sbjct: 356 EAIEKDFLKNKLNQDSGKSTTALH-----QENNKIKELSQEVER 394
>AY642382-1|AAV34207.1| 1135|Homo sapiens GPBP-interacting protein
130d protein.
Length = 1135
Score = 66.9 bits (156), Expect = 7e-10
Identities = 87/400 (21%), Positives = 179/400 (44%), Gaps = 31/400 (7%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE 777
+Q+ L R+++ELE+ +L+K +EL ++K G+ ++ E
Sbjct: 324 QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA--------EVEEL 375
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R +VL+ E + ++LI+ E C L+ L + ++S+ ++ L
Sbjct: 376 RKRVLDMEGKD--EELIKMEEQCRDLNKRLE------RETLQSKDFKLEVEKLSKRIMAL 427
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAK-SLRSDKALDLNTKKTTQLEN 895
+ +E + + + SL+ + EK + K+L Q L++ K ++ +A++ +KT E
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT---EF 484
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK-SKQXXXXXXXXXXXXXXXXX 954
LKE L K+K L ++ DE+ +E KK D L+ +
Sbjct: 485 TLKEDLTKLKTLTVMFVDERK----TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEMYVVMKNAGLS 1013
+ LKS D +K + + K+ DL KL+ ++ DL + + +++
Sbjct: 541 EETKRALKSKTDVEEKMYS--VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 598
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K+ K KL ++ + + L + +++ ++ KLKD+ A +E D ++Y
Sbjct: 599 EKDF-LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKA-IEDDLMKTEDEY 656
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+ LE +N ++ + L++E+++ + ++ K K TS
Sbjct: 657 ETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETS 696
Score = 66.5 bits (155), Expect = 9e-10
Identities = 114/581 (19%), Positives = 246/581 (42%), Gaps = 42/581 (7%)
Query: 540 RDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSI 599
++++ E+E + +++ +EE K ++Q +T + E TN+
Sbjct: 209 QEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAK 268
Query: 600 Q-NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNL--RKTA 654
+ + + A +E+ + L + T+ T+FH D + + N + N +K A
Sbjct: 269 ETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLA 328
Query: 655 A--RVEEDNESLLLQLKKMATKARS--RKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
A R ++ E L+K + + K+S N + + ++ D E
Sbjct: 329 ALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEE 388
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L+++ EQ + +R E Q K+ K +V++L+ +I ++ K N + + +
Sbjct: 389 --LIKMEEQCRDLNKRLERETLQSKD-FKLEVEKLSKRIMALEKLEDAFNKSKQECYSLK 445
Query: 771 SNKLAEERV--KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
N L +ER+ K L E++ ++ ++ E E RL + K+ T +K+ ++ D+
Sbjct: 446 CN-LEKERMTTKQLSQELESLKVRIKELEAIESRLE-KTEFTLKEDLTKLKTLTVMFVDE 503
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
+ + +L+ E + L+A + L+ + K+ T +KL + + ++L+S ++
Sbjct: 504 RKT-MSEKLKKTEDK---LQAASSQLQVEQNKVTTVTEKL-IEETKRALKSKTDVEEKMY 558
Query: 889 KTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
T+ ++LK L +E +++ + + +++ EA +K+ K Q
Sbjct: 559 SVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL 618
Query: 947 XXXXXXXXXXXQAT---------LKSLKDDAQKSFKP--RIPKKPTDLTTKLQ-LKKMVE 994
Q +K+++DD K+ + ++ + K Q L K +E
Sbjct: 619 HQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 678
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
++ E+ + + K E + + L K + E +K E K ++ +A
Sbjct: 679 HVKMELAKYKLAEKT------ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT 732
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+D+ L+GD V K EN N +L + + LT+E++
Sbjct: 733 -EDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
Score = 56.8 bits (131), Expect = 7e-07
Identities = 101/528 (19%), Positives = 213/528 (40%), Gaps = 22/528 (4%)
Query: 595 VTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHM--AANNLRK 652
V ++Q A STP ++ + P +DK E+ H + Y I + A + R+
Sbjct: 115 VLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEK---HKE-SYRRILGQLLVAEKSHRQ 170
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMK 711
T +EE+ ++K + + KL + +EKE + E +K
Sbjct: 171 TILELEEEKRKHKEYMEK-SDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLK 229
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV-TKTS-AGSNTTARRSLTT 769
L + A ++ + + L +++++ELT+ TK + A + T
Sbjct: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK-SRSLDASDQ 828
K + + + D + KL ++ +L +L+ ++ L + +RSL +++
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 349
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS-DKALDLNT 887
+ D+K ++ E + + A+ + L L E K +L+K + R +K L+ T
Sbjct: 350 ELQDIKEKISKGEYGNAGIMAEVEELR--KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 888 KKTTQLENELKEALAKIKELEMICQD--EKSEKKVRFTEAT-KKETDTLKSKQXXXXXXX 944
++ + E+++ +I LE + +D KS+++ + +KE T K
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
+ T +LK+D K + T +LKK + L+ ++
Sbjct: 467 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ 526
Query: 1005 VVMKNAGLSGKEMTAKTKLE-KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
V +++ +TK K ++ K+ E + KN+L+ E K D+ +++
Sbjct: 527 VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1064 GDKDVFANKYKALENE--NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
K+ +A+E + + L+ T + +I +LS +++
Sbjct: 587 MLKNRL-QSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
Score = 55.6 bits (128), Expect = 2e-06
Identities = 109/583 (18%), Positives = 232/583 (39%), Gaps = 45/583 (7%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK---DELQARFIKTE 1241
K E++ ++ RVT A+++ + +RL+ +LT ++ EL +T
Sbjct: 212 KSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH 271
Query: 1242 SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDA-LRQTTNDKYDEATSPVEM 1300
+K EA ++ + E K T LE + + Q +D + + TN+ ++
Sbjct: 272 TKLALAEARVQ----EEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKL 327
Query: 1301 VEMR---XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXX 1357
+ ++EL + K K+ K E ++ E+ +L+ + +E
Sbjct: 328 AALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387
Query: 1358 XXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK--DVKNKD-AELATLKG 1414
+ E + + D + E +KL + +A +K D NK E +LK
Sbjct: 388 ELIKMEEQCRDLNKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEH-SLALEKAEY---EELTGKYELLEEEHV 1470
L + K++++ + + +K+LE LEK E+ E+LT K + L V
Sbjct: 447 NL----EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT-KLKTLTVMFV 501
Query: 1471 VTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ ++ + ++ + +L +L ++ T+ EKL E+ KT+++ + S+
Sbjct: 502 DERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
Query: 1531 ERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERV 1590
+ ER D + +L+A ++ + L + D+ +
Sbjct: 562 K---------ER-------DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLK- 604
Query: 1591 SKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQ 1650
+K+ + ++ E+ K ++ D K + M T DE ++L +
Sbjct: 605 NKLNQDSGKSTTALHQENNKIKELSQEVERL-KLKLKDMKAIEDDLMKT-EDEYETLERR 662
Query: 1651 VSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
+ R + + LE + +A+ K +K+ H + +EE K L ++V
Sbjct: 663 YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEE-EAKSGHLSREVDA 721
Query: 1711 LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
L++++ E + L L + S + +L + ++R + E
Sbjct: 722 LKEKIHE-YMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 763
Score = 48.0 bits (109), Expect = 3e-04
Identities = 79/433 (18%), Positives = 183/433 (42%), Gaps = 44/433 (10%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE--RVKVL 782
R+ + ELE++K K+ +++ I + + + + + K E+ RV L
Sbjct: 169 RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTL 228
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKK------------PKTLIKSRSLDASDQQN 830
++E+ +++ + + +RL A+L+L ++K K + + +Q+
Sbjct: 229 KEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 831 VDLKRQLQV----IEQEASVLRAKTQSLEADNEKLQTENKKL-----QLLKNAKSLR-SD 880
L+++LQ Q+ + AK + ++ N +LQ + L +L + +SLR ++
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 881 KALDLNTKKTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
+ L +K ++ E +A+++EL ++ + K E+ ++ E + L+ +
Sbjct: 349 EELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETL 408
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC 998
+ + Q+ + + + +TTK QL + +E L+
Sbjct: 409 QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-QLSQELESLKV 467
Query: 999 EIGEMYVV---MKNAGLSGKEMTAKTK------------LEKEIDEIRSKLSKNDSEFTN 1043
I E+ + ++ + KE K K + +++ + KL S+
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 1044 EKNRLQTEIAKL-KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
E+N++ T KL ++ L+ DV Y ++ E +L N+ K E+ + +++N
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMY-SVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1103 KLSADLKNATSLQ 1115
L L++ +++
Sbjct: 587 MLKNRLQSLEAIE 599
Score = 47.2 bits (107), Expect = 6e-04
Identities = 126/632 (19%), Positives = 253/632 (40%), Gaps = 52/632 (8%)
Query: 267 KEYQDQIEG----LKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
KEY ++ + L+QE + L+K ++ K + + + + T + T S L +
Sbjct: 183 KEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMV 242
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETLC 381
+ LT R + + LT +E ++L EA+ ++ EQ +L +T
Sbjct: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL---AEARVQEEEQKATRLEKELQTQT 299
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ + + + +L + +Q Q DE R L + + + + K+
Sbjct: 300 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGM-QRENRIKELEQEVARSTEVALRLQRELAE 498
K E + E E K++L++ G + + + E + ++L + + R T + + E+ +
Sbjct: 360 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK 419
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
+ + +L K+ + K + + + E + L LE L+ +++
Sbjct: 420 LSKRIM----ALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELE---SLKVRIKE 471
Query: 559 AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ--NKMIHAASTPSSKEKS 616
E + ++ T + + + E +T++ ++ + AAS+ E++
Sbjct: 472 LEAIESRLEKTE-FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 530
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
++ +K EET+ + ++ + V ++ + L +LK K
Sbjct: 531 KVTTVT-EKLIEETKRAL----------KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
Query: 677 SRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
N+L S+E + K D + L QE K++EL Q+
Sbjct: 580 DLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL---HQE----NNKIKELSQEV 632
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK-KLI 794
E LK ++K++ + + KT T RR N A+ K LE E+ K KL
Sbjct: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERR--YANERDKAQFLSKELEHVKMELAKYKLA 690
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI---EQEASVLRAKT 851
EK L +++ K+ SR +DA ++ + +I + + SVL+ K
Sbjct: 691 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL 750
Query: 852 QSLEADNEKL--QTEN--KKLQLLKN-AKSLR 878
E N L + EN K+L+ ++ +KSLR
Sbjct: 751 NQQENRNRDLGREIENLTKELERYRHFSKSLR 782
Score = 44.4 bits (100), Expect = 0.004
Identities = 65/315 (20%), Positives = 126/315 (40%), Gaps = 13/315 (4%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+N KE ++ + V ++ R+EKE + + DT T S+ +LQ
Sbjct: 265 TNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ 324
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE----AQTRQIEQLRAKLLAAET 379
QK+ L+ ++L + + L + E++ E E ++E+LR ++L E
Sbjct: 325 QKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEG 384
Query: 380 LCEEL--MDEN-EDMKKEL--RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
EEL M+E D+ K L L ++ + L ++ + C L
Sbjct: 385 KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL 444
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQ 493
L+K QL QE + ++ E+ +++ E +KE ++ T + + +
Sbjct: 445 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
+ ++E K + Q E KV+ + + + D+++ + R
Sbjct: 505 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 564
Query: 554 EQLRN---AEEETAN 565
+ L+N AEEE N
Sbjct: 565 DDLKNKLKAEEEKGN 579
Score = 43.6 bits (98), Expect = 0.007
Identities = 107/583 (18%), Positives = 222/583 (38%), Gaps = 46/583 (7%)
Query: 1211 QAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA 1270
Q +V +HR+ +EL EK + + K++ LE E LK + +I S E
Sbjct: 160 QLLVAEKSHRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQ 219
Query: 1271 AKDVHIKQLEDALRQTTN------DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNA 1324
K+ + L++ L + + D+ T+ + + + + L A
Sbjct: 220 EKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEA 279
Query: 1325 KIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL 1384
+++ E E A +LE +L++ K +++ ++L L
Sbjct: 280 RVQ----EEEQKATRLE-KELQTQTTKFHQDQDTIMAKLTNE-------DSQNRQLQQKL 327
Query: 1385 QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKL 1444
+ +++D + ++ ++ + EL +K K+ E + + EL++ + K
Sbjct: 328 AALSRQIDELE-ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKD 386
Query: 1445 EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTL 1504
E + +E E+ + LE E + +K +E E+ ++ ++K L A + K
Sbjct: 387 EELIKME----EQCRDLNKRLERETLQSK-DFKLEVEKLSKRIMALEK-LEDAFNKSKQE 440
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
L ++ + SL+ R+ E + +RL++ E L+ +
Sbjct: 441 CYSLKCNLEKERMTTKQLSQELESLKVRI------KELEAIESRLEKTEFTLKEDLTKLK 494
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
L D K+Q IE++++A K+
Sbjct: 495 TLTVMFVDERKTMSEKLKKTED-----KLQAASSQLQVEQNKVTTVTEKLIEETKRALKS 549
Query: 1625 EITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARI 1684
+ TD + + + RD+LK+ + + ML+ +S+ I+ ++
Sbjct: 550 K-TDVEEKMY-SVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 607
Query: 1685 HRNSISSTDE-EEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEM 1743
+++S ST + NK+ L Q+V L+ +L + + + L + E + E R A
Sbjct: 608 NQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDL-MKTEDEYETLERRYA-- 664
Query: 1744 QSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQ 1786
NE ++ + LS V + +LA E +Q L +
Sbjct: 665 ----NERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFK 703
Score = 41.5 bits (93), Expect = 0.030
Identities = 93/539 (17%), Positives = 195/539 (36%), Gaps = 36/539 (6%)
Query: 1015 KEMTAKTKLEKE-IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ +TA+ L+++ I E+ + + ++ + R+Q E K + +L+ F
Sbjct: 247 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
+ + +N +Q + L +++ QI++L ++ + + D
Sbjct: 307 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA 366
Query: 1134 XXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQ--- 1190
+V + D++ K+ ++ D K++ +++ K+
Sbjct: 367 GIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMA 426
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTS------EKDELQARFIKTE--- 1241
L +D T ++LS EL S E + +++R KTE
Sbjct: 427 LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTL 486
Query: 1242 ----SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSP 1297
+K TL D + K+ E + A + Q+E T +K E T
Sbjct: 487 KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL-QVEQNKVTTVTEKLIEETK- 544
Query: 1298 VEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLK-SDLAKLENXX 1356
++ + +D+L N K+K E+ + +++ M + + L +E
Sbjct: 545 -RALKSKTDVEEKMYSVTKERDDLKN-KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF 602
Query: 1357 XXXXXXXXXXXXXSSYWE--NKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKG 1414
++ + NK KEL +++ + KL M+ D +K +D
Sbjct: 603 LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTED-------- 654
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVT-- 1472
+ + LE+ + L +E E +L EK E ++ L+EE +
Sbjct: 655 EYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGH 714
Query: 1473 -KARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ KE+ E + + + G+ LQ+KL + E++N L+
Sbjct: 715 LSREVDALKEKIH-EYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
Score = 37.1 bits (82), Expect = 0.64
Identities = 49/224 (21%), Positives = 98/224 (43%), Gaps = 21/224 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK---- 321
+++ +D KQE L+ E+ E+ + L + L ++ K S + K
Sbjct: 427 LEKLEDAFNKSKQECYSLKCNLEK-ERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 485
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L++ + +L T DE+K +++K+++ E +L+ S Q+EQ + T+
Sbjct: 486 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQ----LQVEQNKVT-----TVT 536
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+L++E + K D+ + R+D ++ + + + +L +L+
Sbjct: 537 EKLIEETKRALKSKTDVEEKMYSVTKE-RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL 595
Query: 442 ER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
E + D L+ + + K + Q N+IKEL QEV R
Sbjct: 596 EAIEKDFLKNKLNQDSGKSTTALH-----QENNKIKELSQEVER 634
>AL645502-1|CAH70064.1| 976|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 976
Score = 66.9 bits (156), Expect = 7e-10
Identities = 123/604 (20%), Positives = 253/604 (41%), Gaps = 37/604 (6%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETL 380
L + ++L E ++ K ++R+ ES+L E R EAQ + I++L+
Sbjct: 102 LSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLK 161
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
EE + EN+D+ KE +++ A++ E E+T + L+ ++K
Sbjct: 162 LEEGIQENKDLIKENNATRHLCNLLKETCAR-SAEKTKKYEYEREETRQVYMDLNNNIEK 220
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN 500
++L + +AE+ + + D + ++ +E ++E+ + L ++ E
Sbjct: 221 MITAFEEL-RVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKE 279
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAE 560
+K L + + KV++ +E +L+ S+E++ L ++L + +
Sbjct: 280 NKM----KDLTFLLEESRDKVNQ-------LEEKTKLQSENLKQSIEKQHHLTKELEDIK 328
Query: 561 EETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
D Q+ T I C + E + NK A S ++ ++
Sbjct: 329 VSLQRSVSTQKALEEDLQIATKTI--CQLTEEKETQMEESNKARAAHSFVVTEFETTVCS 386
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
L TE+ + + L I L+K ++ +EE + L K++ + + L
Sbjct: 387 LEELLRTEQQRLEKNEDQLKIL----TMELQKKSSELEEMTK--LTNNKEVELEELKKVL 440
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKL--LLELNEQEATVLRRKVEELEQDKEAL 738
K ++ N EK +E E +L LL+ E+E L ++ + ++
Sbjct: 441 -----GEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
K+VK+L +++ + K T+ L+ + +L +E + E+ ++ + ++
Sbjct: 496 SKEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQE-TSDMTLELKNQQEDINNNKK 553
Query: 799 DCERLHAELSLAQKKPKTLIKSRSL--DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
ER+ ++ Q+ L + Q+ ++K +L E+ + LR + ++
Sbjct: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
E+LQ ENK L+ A+S K L++ K +LE EL+ A K E+ Q E
Sbjct: 614 YIEELQQENKALKKKGTAES----KQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIE 669
Query: 917 EKKV 920
+KK+
Sbjct: 670 DKKI 673
Score = 62.1 bits (144), Expect = 2e-08
Identities = 85/406 (20%), Positives = 170/406 (41%), Gaps = 29/406 (7%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR-----SLTTNSNKLAEERV 779
++++ + E+ L Q+ E +K+ +T S + L + + K + E+
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
L E+++++ L + L +L +A K L + + + V
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
E E +V + + L + ++L+ +L++L +S + L+ TK T E EL+E
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSE-LEEMTKLTNNKEVELEE 435
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+ E E + + K +K+ E E + + Q Q
Sbjct: 436 LKKVLGEKETLLYENKQFEKIA-EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
K +KD + ++ K T+LT+ KL L+ ++L E +M + +KN ++
Sbjct: 495 YSKEVKDLKTELENEKL--KNTELTSHCNKLSLEN--KELTQETSDMTLELKN---QQED 547
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKYKA 1075
+ K E+ + + L + +++ NE ++ E+ + +D V KL+ ++ N K
Sbjct: 548 INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
Query: 1076 LENENS---NLSNQCKTL----TEEMKNR---EAQINKLSADLKNA 1111
+EN+N L + K L T E K E ++NKL +L++A
Sbjct: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESA 653
Score = 60.5 bits (140), Expect = 6e-08
Identities = 138/750 (18%), Positives = 296/750 (39%), Gaps = 57/750 (7%)
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L ++ E++++ K + + ++++ SK+ K A + L + K++ + + ++
Sbjct: 109 LYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQ 167
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ D +++ + C L + + +K K R + + Q +DL ++ +
Sbjct: 168 ENKDLIKENNATRHL-CNLLKETCARSAEKTKKYEYER--EETRQVYMDLNNNIEKMITA 224
Query: 844 ASVLRAKTQSLEADNE-KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA 902
LR + ++ + KL+ + +K+Q L+ K ++ K+ + L ++ E
Sbjct: 225 FEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK----KEINDKEKQVSLLLIQITEKEN 280
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
K+K+L + ++ + +K + E TK +++ LK +T K
Sbjct: 281 KMKDLTFLLEESR-DKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
+L++D Q I K T+ + +M E + +VV + T
Sbjct: 340 ALEEDLQ------IATKTICQLTEEKETQMEESNKARAAHSFVVTEFE-------TTVCS 386
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
LE+ + + +L KN+ + LQ + ++L+++ KL +K+V + K + E
Sbjct: 387 LEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT-KLTNNKEVELEELKKVLGEKET 445
Query: 1083 L---SNQCKTLTEEMKNREAQ-INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
L + Q + + EE+K E + I L A K L+ ++
Sbjct: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLT--AITTSEQYYSKEVKDLK 503
Query: 1139 XXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ N T++ NKL E + T++ D +L +++ +
Sbjct: 504 TELENEKLKN-TELTSHCNKLSLENKELTQETSDMTL--------------ELKNQQEDI 548
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
Q L T +L EL ++EL+ + + + K E +L+
Sbjct: 549 NNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV 608
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
ENK +E + ++ +K+ A + N Y+ + +E+ E+ Q
Sbjct: 609 ENKNKYIEE-LQQENKALKKKGTAESKQLN-VYEIKVNKLEL-ELESAKQKFGEITDTYQ 665
Query: 1319 DELNNAKIKLEKTEAESSAAKL---EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
E+ + KI E E AK+ E +L+ ++ K ++
Sbjct: 666 KEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDK--RCQHKIAEMVALMEKHKHQYDK 723
Query: 1376 KAKELDTDL---QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITE 1432
+E D++L +S+ ++ +R + + ++ N AEL ++K +L+I + + E
Sbjct: 724 IIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
Query: 1433 LKQEYEETVKKLEHSLALEKAE-YEELTGK 1461
+E K + LE E Y +L K
Sbjct: 784 NTATLKEKKDKKTQTFLLETPEIYWKLDSK 813
Score = 56.4 bits (130), Expect = 1e-06
Identities = 118/696 (16%), Positives = 257/696 (36%), Gaps = 46/696 (6%)
Query: 840 IEQEASVLRAKTQSLEADN---EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
+ Q+ S L+ + +EA ++LQ N+K+ L K + ++ +K L T L N
Sbjct: 127 LRQKESKLQENRKIIEAQRKAIQELQFGNEKVSL-KLEEGIQENKDLIKENNATRHLCNL 185
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
LKE A+ E + E+ E + + + + + +
Sbjct: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245
Query: 957 XQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
++ L+ + +K + +K L L + + E ++ ++ +++ + +
Sbjct: 246 DYEKIQHLEQEYKKEINDK--EKQVSL-----LLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKAL 1076
+ KTKL+ E ++ + K T E ++ + + LE D + L
Sbjct: 299 LEEKTKLQSE--NLKQSIEKQH-HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQL 355
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXX 1136
E + E K R A ++ SL+ +
Sbjct: 356 TEEKET------QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILT 409
Query: 1137 XXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKD 1196
+++ TK+ +K L+E+ K +G+ K E+ T ++
Sbjct: 410 MELQKKSSELEEMTKLTNNKEVELEEL---KKVLGEKETLLYENKQFEKIAEELKGTEQE 466
Query: 1197 RV---TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK-TE--SKFITLEAE 1250
+ Q + + + S E+ K EL+ +K TE S L E
Sbjct: 467 LIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLE 526
Query: 1251 MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
++L + + L++ + + KQ E L+Q N + E ++R
Sbjct: 527 NKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETET-------QLRNELEYV 579
Query: 1311 XXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXS 1370
+DE+ K KL+K+E + + ++ + +L+
Sbjct: 580 REELKQKRDEV---KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 1371 SYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI 1430
+ +E K +L+ +L+S ++K + + K++++K L +++ + + K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQ 696
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEEL-------TGKYELLEEEHVVTKARLTVEKEQA 1483
E+ + + + ++ + K +Y+++ G Y+ E+E +A L +E
Sbjct: 697 KEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL 756
Query: 1484 QGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
+ ELL V+K+L E + L+ + +A +K
Sbjct: 757 KAELLSVKKQLEIEREEKEKLKREAKENTATLKEKK 792
Score = 53.2 bits (122), Expect = 9e-06
Identities = 92/458 (20%), Positives = 177/458 (38%), Gaps = 35/458 (7%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEADPAEM 710
K + E + LQ + +A+ + + N K+S++ E + +
Sbjct: 120 KVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNAT 179
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ L L ++ K ++ E ++E ++ +L + I + A S
Sbjct: 180 RHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEM 239
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK--TLIKSRSLDASDQ 828
KL E+ K+ E E +K++ +KE+ L +++ + K K T + S D +Q
Sbjct: 240 HFKLKEDYEKIQHLE-QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
K Q + ++Q T+ LE LQ + L+ + + L +
Sbjct: 299 LEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEE 358
Query: 889 KTTQLENELKEALAK---IKELEM-ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K TQ+E K A + E E +C E+ + + + +K D LK
Sbjct: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ--QRLEKNEDQLK--------IL 408
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L + K+ + K + +K T L Q +K+ E+L+ E+
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
GL + A+ K +++ + ++ ++ ++ E L+TE+ K N +L
Sbjct: 469 ------GL----LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS 518
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
NK L EN L+ + +T E+KN++ IN
Sbjct: 519 H----CNK---LSLENKELTQETSDMTLELKNQQEDIN 549
Score = 51.6 bits (118), Expect = 3e-05
Identities = 120/606 (19%), Positives = 242/606 (39%), Gaps = 58/606 (9%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
E L++Q + + L H + D +K HL Q+ ++ ++ E + S QI + K+
Sbjct: 226 EELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSL--LLIQITEKENKMK 283
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
L EE D+ ++++ + L + E ++ L++++ + L
Sbjct: 284 DLTFLLEESRDKVNQLEEKTK-LQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALE 342
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
L+ + QL +EK E ++ E + E E V S E LR +++
Sbjct: 343 EDLQIATKTICQLTEEK---ETQMEE--SNKARAAHSFVVTEFETTVC-SLEELLRTEQQ 396
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD---L 552
E N ++ E ++++ + + E+ ++L + + L +
Sbjct: 397 RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKI 456
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---SIQNKMIHAAST 609
E+L+ E+E Q D ++ I T + + S+ V + ++N+ +
Sbjct: 457 AEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTEL 516
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN--------NLRKTAARVEEDN 661
S K + + T + I N+ NL++T ++ +
Sbjct: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
E + +LK+ + + + N L + N N E + + +K ++
Sbjct: 577 EYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVK 780
V KV +LE + E+ K++ E+T + + N L E E+ K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKK----------ISEENLLEEVEKAK 686
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
V+ DE +++K++ ++ C+ AE+ +K K + ++ D + K +
Sbjct: 687 VIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQY-DKIIEERDSELGLYKSK---- 738
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
EQE S LRA SLE ++ N K +LL S++ K L++ ++ +L+ E KE
Sbjct: 739 EQEQSSLRA---SLE-----IELSNLKAELL----SVK--KQLEIEREEKEKLKREAKEN 784
Query: 901 LAKIKE 906
A +KE
Sbjct: 785 TATLKE 790
Score = 48.0 bits (109), Expect = 3e-04
Identities = 63/287 (21%), Positives = 128/287 (44%), Gaps = 19/287 (6%)
Query: 278 QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLR 337
+EV L+ E EK K+ L + NK T +S++ EL ED+
Sbjct: 497 KEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQETSDMTL------ELKNQQEDIN 549
Query: 338 DEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAAETLCEELMDENEDMKKELR 396
+ KK + +++IE+ E TE Q R ++E +R +L + +D++E+ LR
Sbjct: 550 NNKKQEERMLKQIENLQE----TETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR 605
Query: 397 DLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHE 456
++ + E+ E +L+++ K V K+ K E + + +Q+ E
Sbjct: 606 ----KQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 457 KKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP 516
+ + + EN ++E+E+ + E A++LQ+E+ + +LM+ +
Sbjct: 662 DTYQKEIEDKK-ISEENLLEEVEKAKVIADE-AVKLQKEIDKRCQHKIAEMVALMEKHKH 719
Query: 517 ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLRNAEEE 562
+ K+ + G + Q L+ SLE E ++L+ +L + +++
Sbjct: 720 QYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQ 766
Score = 34.7 bits (76), Expect = 3.4
Identities = 51/309 (16%), Positives = 120/309 (38%), Gaps = 16/309 (5%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
E++E + ++ + + +L+ EN + + I+ LE ++ N
Sbjct: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
Query: 1289 DKYDEAT-SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKS 1347
DK + + +++ E +D++N + EKT+ +S K + +
Sbjct: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE---EKTKLQSENLKQSIEKQHH 319
Query: 1348 DLAKLENXXXXXXXXXXXXXXXSSYWENKAK---ELDTDLQSERKKLDRMRIAHDKDVKN 1404
+LE+ + K +L + +++ ++ ++ R AH V
Sbjct: 320 LTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTE 379
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+ + +L+ L+ +Q ++ L E ++ +LE L + EL ++
Sbjct: 380 FETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKV 439
Query: 1465 LEEEHVVTKARLTVEK--EQAQG---ELLHVQKELSTALGEIKTLQEKLGTESAAWNTE- 1518
L E+ + EK E+ +G EL+ + + + +++ + T ++ E
Sbjct: 440 LGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEV 499
Query: 1519 ---KTEMQN 1524
KTE++N
Sbjct: 500 KDLKTELEN 508
>AL358372-3|CAH72848.1| 792|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 792
Score = 66.9 bits (156), Expect = 7e-10
Identities = 123/604 (20%), Positives = 253/604 (41%), Gaps = 37/604 (6%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETL 380
L + ++L E ++ K ++R+ ES+L E R EAQ + I++L+
Sbjct: 102 LSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLK 161
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
EE + EN+D+ KE +++ A++ E E+T + L+ ++K
Sbjct: 162 LEEGIQENKDLIKENNATRHLCNLLKETCAR-SAEKTKKYEYEREETRQVYMDLNNNIEK 220
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN 500
++L + +AE+ + + D + ++ +E ++E+ + L ++ E
Sbjct: 221 MITAFEEL-RVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKE 279
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAE 560
+K L + + KV++ +E +L+ S+E++ L ++L + +
Sbjct: 280 NKM----KDLTFLLEESRDKVNQ-------LEEKTKLQSENLKQSIEKQHHLTKELEDIK 328
Query: 561 EETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
D Q+ T I C + E + NK A S ++ ++
Sbjct: 329 VSLQRSVSTQKALEEDLQIATKTI--CQLTEEKETQMEESNKARAAHSFVVTEFETTVCS 386
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
L TE+ + + L I L+K ++ +EE + L K++ + + L
Sbjct: 387 LEELLRTEQQRLEKNEDQLKIL----TMELQKKSSELEEMTK--LTNNKEVELEELKKVL 440
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKL--LLELNEQEATVLRRKVEELEQDKEAL 738
K ++ N EK +E E +L LL+ E+E L ++ + ++
Sbjct: 441 -----GEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
K+VK+L +++ + K T+ L+ + +L +E + E+ ++ + ++
Sbjct: 496 SKEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQE-TSDMTLELKNQQEDINNNKK 553
Query: 799 DCERLHAELSLAQKKPKTLIKSRSL--DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
ER+ ++ Q+ L + Q+ ++K +L E+ + LR + ++
Sbjct: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
E+LQ ENK L+ A+S K L++ K +LE EL+ A K E+ Q E
Sbjct: 614 YIEELQQENKALKKKGTAES----KQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIE 669
Query: 917 EKKV 920
+KK+
Sbjct: 670 DKKI 673
Score = 62.1 bits (144), Expect = 2e-08
Identities = 85/406 (20%), Positives = 170/406 (41%), Gaps = 29/406 (7%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR-----SLTTNSNKLAEERV 779
++++ + E+ L Q+ E +K+ +T S + L + + K + E+
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
L E+++++ L + L +L +A K L + + + V
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
E E +V + + L + ++L+ +L++L +S + L+ TK T E EL+E
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSE-LEEMTKLTNNKEVELEE 435
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+ E E + + K +K+ E E + + Q Q
Sbjct: 436 LKKVLGEKETLLYENKQFEKIA-EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
K +KD + ++ K T+LT+ KL L+ ++L E +M + +KN ++
Sbjct: 495 YSKEVKDLKTELENEKL--KNTELTSHCNKLSLEN--KELTQETSDMTLELKN---QQED 547
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKYKA 1075
+ K E+ + + L + +++ NE ++ E+ + +D V KL+ ++ N K
Sbjct: 548 INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
Query: 1076 LENENS---NLSNQCKTL----TEEMKNR---EAQINKLSADLKNA 1111
+EN+N L + K L T E K E ++NKL +L++A
Sbjct: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESA 653
Score = 56.4 bits (130), Expect = 1e-06
Identities = 118/696 (16%), Positives = 257/696 (36%), Gaps = 46/696 (6%)
Query: 840 IEQEASVLRAKTQSLEADN---EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
+ Q+ S L+ + +EA ++LQ N+K+ L K + ++ +K L T L N
Sbjct: 127 LRQKESKLQENRKIIEAQRKAIQELQFGNEKVSL-KLEEGIQENKDLIKENNATRHLCNL 185
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
LKE A+ E + E+ E + + + + + +
Sbjct: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245
Query: 957 XQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
++ L+ + +K + +K L L + + E ++ ++ +++ + +
Sbjct: 246 DYEKIQHLEQEYKKEINDK--EKQVSL-----LLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKAL 1076
+ KTKL+ E ++ + K T E ++ + + LE D + L
Sbjct: 299 LEEKTKLQSE--NLKQSIEKQH-HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQL 355
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXX 1136
E + E K R A ++ SL+ +
Sbjct: 356 TEEKET------QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILT 409
Query: 1137 XXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKD 1196
+++ TK+ +K L+E+ K +G+ K E+ T ++
Sbjct: 410 MELQKKSSELEEMTKLTNNKEVELEEL---KKVLGEKETLLYENKQFEKIAEELKGTEQE 466
Query: 1197 RV---TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK-TE--SKFITLEAE 1250
+ Q + + + S E+ K EL+ +K TE S L E
Sbjct: 467 LIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLE 526
Query: 1251 MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
++L + + L++ + + KQ E L+Q N + E ++R
Sbjct: 527 NKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETET-------QLRNELEYV 579
Query: 1311 XXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXS 1370
+DE+ K KL+K+E + + ++ + +L+
Sbjct: 580 REELKQKRDEV---KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 1371 SYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI 1430
+ +E K +L+ +L+S ++K + + K++++K L +++ + + K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQ 696
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEEL-------TGKYELLEEEHVVTKARLTVEKEQA 1483
E+ + + + ++ + K +Y+++ G Y+ E+E +A L +E
Sbjct: 697 KEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL 756
Query: 1484 QGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
+ ELL V+K+L E + L+ + +A +K
Sbjct: 757 KAELLSVKKQLEIEREEKEKLKREAKENTATLKEKK 792
Score = 53.2 bits (122), Expect = 9e-06
Identities = 92/458 (20%), Positives = 177/458 (38%), Gaps = 35/458 (7%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEADPAEM 710
K + E + LQ + +A+ + + N K+S++ E + +
Sbjct: 120 KVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNAT 179
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ L L ++ K ++ E ++E ++ +L + I + A S
Sbjct: 180 RHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEM 239
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK--TLIKSRSLDASDQ 828
KL E+ K+ E E +K++ +KE+ L +++ + K K T + S D +Q
Sbjct: 240 HFKLKEDYEKIQHLE-QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
K Q + ++Q T+ LE LQ + L+ + + L +
Sbjct: 299 LEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEE 358
Query: 889 KTTQLENELKEALAK---IKELEM-ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K TQ+E K A + E E +C E+ + + + +K D LK
Sbjct: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ--QRLEKNEDQLK--------IL 408
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L + K+ + K + +K T L Q +K+ E+L+ E+
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
GL + A+ K +++ + ++ ++ ++ E L+TE+ K N +L
Sbjct: 469 ------GL----LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS 518
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
NK L EN L+ + +T E+KN++ IN
Sbjct: 519 H----CNK---LSLENKELTQETSDMTLELKNQQEDIN 549
Score = 51.6 bits (118), Expect = 3e-05
Identities = 120/606 (19%), Positives = 242/606 (39%), Gaps = 58/606 (9%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
E L++Q + + L H + D +K HL Q+ ++ ++ E + S QI + K+
Sbjct: 226 EELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSL--LLIQITEKENKMK 283
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
L EE D+ ++++ + L + E ++ L++++ + L
Sbjct: 284 DLTFLLEESRDKVNQLEEKTK-LQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALE 342
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
L+ + QL +EK E ++ E + E E V S E LR +++
Sbjct: 343 EDLQIATKTICQLTEEK---ETQMEE--SNKARAAHSFVVTEFETTVC-SLEELLRTEQQ 396
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD---L 552
E N ++ E ++++ + + E+ ++L + + L +
Sbjct: 397 RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKI 456
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---SIQNKMIHAAST 609
E+L+ E+E Q D ++ I T + + S+ V + ++N+ +
Sbjct: 457 AEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTEL 516
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN--------NLRKTAARVEEDN 661
S K + + T + I N+ NL++T ++ +
Sbjct: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
E + +LK+ + + + N L + N N E + + +K ++
Sbjct: 577 EYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVK 780
V KV +LE + E+ K++ E+T + + N L E E+ K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKK----------ISEENLLEEVEKAK 686
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
V+ DE +++K++ ++ C+ AE+ +K K + ++ D + K +
Sbjct: 687 VIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQY-DKIIEERDSELGLYKSK---- 738
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
EQE S LRA SLE ++ N K +LL S++ K L++ ++ +L+ E KE
Sbjct: 739 EQEQSSLRA---SLE-----IELSNLKAELL----SVK--KQLEIEREEKEKLKREAKEN 784
Query: 901 LAKIKE 906
A +KE
Sbjct: 785 TATLKE 790
Score = 48.0 bits (109), Expect = 3e-04
Identities = 63/287 (21%), Positives = 128/287 (44%), Gaps = 19/287 (6%)
Query: 278 QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLR 337
+EV L+ E EK K+ L + NK T +S++ EL ED+
Sbjct: 497 KEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQETSDMTL------ELKNQQEDIN 549
Query: 338 DEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAAETLCEELMDENEDMKKELR 396
+ KK + +++IE+ E TE Q R ++E +R +L + +D++E+ LR
Sbjct: 550 NNKKQEERMLKQIENLQE----TETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR 605
Query: 397 DLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHE 456
++ + E+ E +L+++ K V K+ K E + + +Q+ E
Sbjct: 606 ----KQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 457 KKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP 516
+ + + EN ++E+E+ + E A++LQ+E+ + +LM+ +
Sbjct: 662 DTYQKEIEDKK-ISEENLLEEVEKAKVIADE-AVKLQKEIDKRCQHKIAEMVALMEKHKH 719
Query: 517 ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLRNAEEE 562
+ K+ + G + Q L+ SLE E ++L+ +L + +++
Sbjct: 720 QYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQ 766
Score = 34.7 bits (76), Expect = 3.4
Identities = 51/309 (16%), Positives = 120/309 (38%), Gaps = 16/309 (5%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
E++E + ++ + + +L+ EN + + I+ LE ++ N
Sbjct: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
Query: 1289 DKYDEAT-SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKS 1347
DK + + +++ E +D++N + EKT+ +S K + +
Sbjct: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE---EKTKLQSENLKQSIEKQHH 319
Query: 1348 DLAKLENXXXXXXXXXXXXXXXSSYWENKAK---ELDTDLQSERKKLDRMRIAHDKDVKN 1404
+LE+ + K +L + +++ ++ ++ R AH V
Sbjct: 320 LTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTE 379
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+ + +L+ L+ +Q ++ L E ++ +LE L + EL ++
Sbjct: 380 FETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKV 439
Query: 1465 LEEEHVVTKARLTVEK--EQAQG---ELLHVQKELSTALGEIKTLQEKLGTESAAWNTE- 1518
L E+ + EK E+ +G EL+ + + + +++ + T ++ E
Sbjct: 440 LGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEV 499
Query: 1519 ---KTEMQN 1524
KTE++N
Sbjct: 500 KDLKTELEN 508
>AL358372-2|CAH72847.1| 976|Homo sapiens synaptonemal complex
protein 1 protein.
Length = 976
Score = 66.9 bits (156), Expect = 7e-10
Identities = 123/604 (20%), Positives = 253/604 (41%), Gaps = 37/604 (6%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETL 380
L + ++L E ++ K ++R+ ES+L E R EAQ + I++L+
Sbjct: 102 LSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLK 161
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
EE + EN+D+ KE +++ A++ E E+T + L+ ++K
Sbjct: 162 LEEGIQENKDLIKENNATRHLCNLLKETCAR-SAEKTKKYEYEREETRQVYMDLNNNIEK 220
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN 500
++L + +AE+ + + D + ++ +E ++E+ + L ++ E
Sbjct: 221 MITAFEEL-RVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKE 279
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAE 560
+K L + + KV++ +E +L+ S+E++ L ++L + +
Sbjct: 280 NKM----KDLTFLLEESRDKVNQ-------LEEKTKLQSENLKQSIEKQHHLTKELEDIK 328
Query: 561 EETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
D Q+ T I C + E + NK A S ++ ++
Sbjct: 329 VSLQRSVSTQKALEEDLQIATKTI--CQLTEEKETQMEESNKARAAHSFVVTEFETTVCS 386
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
L TE+ + + L I L+K ++ +EE + L K++ + + L
Sbjct: 387 LEELLRTEQQRLEKNEDQLKIL----TMELQKKSSELEEMTK--LTNNKEVELEELKKVL 440
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKL--LLELNEQEATVLRRKVEELEQDKEAL 738
K ++ N EK +E E +L LL+ E+E L ++ + ++
Sbjct: 441 -----GEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
K+VK+L +++ + K T+ L+ + +L +E + E+ ++ + ++
Sbjct: 496 SKEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQE-TSDMTLELKNQQEDINNNKK 553
Query: 799 DCERLHAELSLAQKKPKTLIKSRSL--DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
ER+ ++ Q+ L + Q+ ++K +L E+ + LR + ++
Sbjct: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
E+LQ ENK L+ A+S K L++ K +LE EL+ A K E+ Q E
Sbjct: 614 YIEELQQENKALKKKGTAES----KQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIE 669
Query: 917 EKKV 920
+KK+
Sbjct: 670 DKKI 673
Score = 62.1 bits (144), Expect = 2e-08
Identities = 85/406 (20%), Positives = 170/406 (41%), Gaps = 29/406 (7%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR-----SLTTNSNKLAEERV 779
++++ + E+ L Q+ E +K+ +T S + L + + K + E+
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
L E+++++ L + L +L +A K L + + + V
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
E E +V + + L + ++L+ +L++L +S + L+ TK T E EL+E
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSE-LEEMTKLTNNKEVELEE 435
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+ E E + + K +K+ E E + + Q Q
Sbjct: 436 LKKVLGEKETLLYENKQFEKIA-EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
K +KD + ++ K T+LT+ KL L+ ++L E +M + +KN ++
Sbjct: 495 YSKEVKDLKTELENEKL--KNTELTSHCNKLSLEN--KELTQETSDMTLELKN---QQED 547
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKYKA 1075
+ K E+ + + L + +++ NE ++ E+ + +D V KL+ ++ N K
Sbjct: 548 INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
Query: 1076 LENENS---NLSNQCKTL----TEEMKNR---EAQINKLSADLKNA 1111
+EN+N L + K L T E K E ++NKL +L++A
Sbjct: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESA 653
Score = 60.5 bits (140), Expect = 6e-08
Identities = 138/750 (18%), Positives = 296/750 (39%), Gaps = 57/750 (7%)
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L ++ E++++ K + + ++++ SK+ K A + L + K++ + + ++
Sbjct: 109 LYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQ 167
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ D +++ + C L + + +K K R + + Q +DL ++ +
Sbjct: 168 ENKDLIKENNATRHL-CNLLKETCARSAEKTKKYEYER--EETRQVYMDLNNNIEKMITA 224
Query: 844 ASVLRAKTQSLEADNE-KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA 902
LR + ++ + KL+ + +K+Q L+ K ++ K+ + L ++ E
Sbjct: 225 FEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK----KEINDKEKQVSLLLIQITEKEN 280
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
K+K+L + ++ + +K + E TK +++ LK +T K
Sbjct: 281 KMKDLTFLLEESR-DKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
+L++D Q I K T+ + +M E + +VV + T
Sbjct: 340 ALEEDLQ------IATKTICQLTEEKETQMEESNKARAAHSFVVTEFE-------TTVCS 386
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
LE+ + + +L KN+ + LQ + ++L+++ KL +K+V + K + E
Sbjct: 387 LEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT-KLTNNKEVELEELKKVLGEKET 445
Query: 1083 L---SNQCKTLTEEMKNREAQ-INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
L + Q + + EE+K E + I L A K L+ ++
Sbjct: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLT--AITTSEQYYSKEVKDLK 503
Query: 1139 XXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ N T++ NKL E + T++ D +L +++ +
Sbjct: 504 TELENEKLKN-TELTSHCNKLSLENKELTQETSDMTL--------------ELKNQQEDI 548
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
Q L T +L EL ++EL+ + + + K E +L+
Sbjct: 549 NNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV 608
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
ENK +E + ++ +K+ A + N Y+ + +E+ E+ Q
Sbjct: 609 ENKNKYIEE-LQQENKALKKKGTAESKQLN-VYEIKVNKLEL-ELESAKQKFGEITDTYQ 665
Query: 1319 DELNNAKIKLEKTEAESSAAKL---EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
E+ + KI E E AK+ E +L+ ++ K ++
Sbjct: 666 KEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDK--RCQHKIAEMVALMEKHKHQYDK 723
Query: 1376 KAKELDTDL---QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITE 1432
+E D++L +S+ ++ +R + + ++ N AEL ++K +L+I + + E
Sbjct: 724 IIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
Query: 1433 LKQEYEETVKKLEHSLALEKAE-YEELTGK 1461
+E K + LE E Y +L K
Sbjct: 784 NTATLKEKKDKKTQTFLLETPEIYWKLDSK 813
Score = 56.4 bits (130), Expect = 1e-06
Identities = 118/696 (16%), Positives = 257/696 (36%), Gaps = 46/696 (6%)
Query: 840 IEQEASVLRAKTQSLEADN---EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
+ Q+ S L+ + +EA ++LQ N+K+ L K + ++ +K L T L N
Sbjct: 127 LRQKESKLQENRKIIEAQRKAIQELQFGNEKVSL-KLEEGIQENKDLIKENNATRHLCNL 185
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
LKE A+ E + E+ E + + + + + +
Sbjct: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245
Query: 957 XQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
++ L+ + +K + +K L L + + E ++ ++ +++ + +
Sbjct: 246 DYEKIQHLEQEYKKEINDK--EKQVSL-----LLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKAL 1076
+ KTKL+ E ++ + K T E ++ + + LE D + L
Sbjct: 299 LEEKTKLQSE--NLKQSIEKQH-HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQL 355
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXX 1136
E + E K R A ++ SL+ +
Sbjct: 356 TEEKET------QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILT 409
Query: 1137 XXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKD 1196
+++ TK+ +K L+E+ K +G+ K E+ T ++
Sbjct: 410 MELQKKSSELEEMTKLTNNKEVELEEL---KKVLGEKETLLYENKQFEKIAEELKGTEQE 466
Query: 1197 RV---TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK-TE--SKFITLEAE 1250
+ Q + + + S E+ K EL+ +K TE S L E
Sbjct: 467 LIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLE 526
Query: 1251 MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
++L + + L++ + + KQ E L+Q N + E ++R
Sbjct: 527 NKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETET-------QLRNELEYV 579
Query: 1311 XXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXS 1370
+DE+ K KL+K+E + + ++ + +L+
Sbjct: 580 REELKQKRDEV---KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 1371 SYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI 1430
+ +E K +L+ +L+S ++K + + K++++K L +++ + + K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQ 696
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEEL-------TGKYELLEEEHVVTKARLTVEKEQA 1483
E+ + + + ++ + K +Y+++ G Y+ E+E +A L +E
Sbjct: 697 KEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL 756
Query: 1484 QGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
+ ELL V+K+L E + L+ + +A +K
Sbjct: 757 KAELLSVKKQLEIEREEKEKLKREAKENTATLKEKK 792
Score = 53.2 bits (122), Expect = 9e-06
Identities = 92/458 (20%), Positives = 177/458 (38%), Gaps = 35/458 (7%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEADPAEM 710
K + E + LQ + +A+ + + N K+S++ E + +
Sbjct: 120 KVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNAT 179
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ L L ++ K ++ E ++E ++ +L + I + A S
Sbjct: 180 RHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEM 239
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK--TLIKSRSLDASDQ 828
KL E+ K+ E E +K++ +KE+ L +++ + K K T + S D +Q
Sbjct: 240 HFKLKEDYEKIQHLE-QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
K Q + ++Q T+ LE LQ + L+ + + L +
Sbjct: 299 LEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEE 358
Query: 889 KTTQLENELKEALAK---IKELEM-ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K TQ+E K A + E E +C E+ + + + +K D LK
Sbjct: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ--QRLEKNEDQLK--------IL 408
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L + K+ + K + +K T L Q +K+ E+L+ E+
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
GL + A+ K +++ + ++ ++ ++ E L+TE+ K N +L
Sbjct: 469 ------GL----LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS 518
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
NK L EN L+ + +T E+KN++ IN
Sbjct: 519 H----CNK---LSLENKELTQETSDMTLELKNQQEDIN 549
Score = 51.6 bits (118), Expect = 3e-05
Identities = 120/606 (19%), Positives = 242/606 (39%), Gaps = 58/606 (9%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
E L++Q + + L H + D +K HL Q+ ++ ++ E + S QI + K+
Sbjct: 226 EELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSL--LLIQITEKENKMK 283
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
L EE D+ ++++ + L + E ++ L++++ + L
Sbjct: 284 DLTFLLEESRDKVNQLEEKTK-LQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALE 342
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
L+ + QL +EK E ++ E + E E V S E LR +++
Sbjct: 343 EDLQIATKTICQLTEEK---ETQMEE--SNKARAAHSFVVTEFETTVC-SLEELLRTEQQ 396
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD---L 552
E N ++ E ++++ + + E+ ++L + + L +
Sbjct: 397 RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKI 456
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---SIQNKMIHAAST 609
E+L+ E+E Q D ++ I T + + S+ V + ++N+ +
Sbjct: 457 AEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTEL 516
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN--------NLRKTAARVEEDN 661
S K + + T + I N+ NL++T ++ +
Sbjct: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
E + +LK+ + + + N L + N N E + + +K ++
Sbjct: 577 EYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVK 780
V KV +LE + E+ K++ E+T + + N L E E+ K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKK----------ISEENLLEEVEKAK 686
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
V+ DE +++K++ ++ C+ AE+ +K K + ++ D + K +
Sbjct: 687 VIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQY-DKIIEERDSELGLYKSK---- 738
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
EQE S LRA SLE ++ N K +LL S++ K L++ ++ +L+ E KE
Sbjct: 739 EQEQSSLRA---SLE-----IELSNLKAELL----SVK--KQLEIEREEKEKLKREAKEN 784
Query: 901 LAKIKE 906
A +KE
Sbjct: 785 TATLKE 790
Score = 48.0 bits (109), Expect = 3e-04
Identities = 63/287 (21%), Positives = 128/287 (44%), Gaps = 19/287 (6%)
Query: 278 QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLR 337
+EV L+ E EK K+ L + NK T +S++ EL ED+
Sbjct: 497 KEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQETSDMTL------ELKNQQEDIN 549
Query: 338 DEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAAETLCEELMDENEDMKKELR 396
+ KK + +++IE+ E TE Q R ++E +R +L + +D++E+ LR
Sbjct: 550 NNKKQEERMLKQIENLQE----TETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR 605
Query: 397 DLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHE 456
++ + E+ E +L+++ K V K+ K E + + +Q+ E
Sbjct: 606 ----KQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 457 KKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP 516
+ + + EN ++E+E+ + E A++LQ+E+ + +LM+ +
Sbjct: 662 DTYQKEIEDKK-ISEENLLEEVEKAKVIADE-AVKLQKEIDKRCQHKIAEMVALMEKHKH 719
Query: 517 ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLRNAEEE 562
+ K+ + G + Q L+ SLE E ++L+ +L + +++
Sbjct: 720 QYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQ 766
Score = 34.7 bits (76), Expect = 3.4
Identities = 51/309 (16%), Positives = 120/309 (38%), Gaps = 16/309 (5%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
E++E + ++ + + +L+ EN + + I+ LE ++ N
Sbjct: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
Query: 1289 DKYDEAT-SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKS 1347
DK + + +++ E +D++N + EKT+ +S K + +
Sbjct: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE---EKTKLQSENLKQSIEKQHH 319
Query: 1348 DLAKLENXXXXXXXXXXXXXXXSSYWENKAK---ELDTDLQSERKKLDRMRIAHDKDVKN 1404
+LE+ + K +L + +++ ++ ++ R AH V
Sbjct: 320 LTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTE 379
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+ + +L+ L+ +Q ++ L E ++ +LE L + EL ++
Sbjct: 380 FETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKV 439
Query: 1465 LEEEHVVTKARLTVEK--EQAQG---ELLHVQKELSTALGEIKTLQEKLGTESAAWNTE- 1518
L E+ + EK E+ +G EL+ + + + +++ + T ++ E
Sbjct: 440 LGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEV 499
Query: 1519 ---KTEMQN 1524
KTE++N
Sbjct: 500 KDLKTELEN 508
>AF514869-1|AAQ08179.1| 1133|Homo sapiens GPBP-interacting protein
130c protein.
Length = 1133
Score = 66.9 bits (156), Expect = 7e-10
Identities = 87/400 (21%), Positives = 179/400 (44%), Gaps = 31/400 (7%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE 777
+Q+ L R+++ELE+ +L+K +EL ++K G+ ++ E
Sbjct: 324 QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA--------EVEEL 375
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R +VL+ E + ++LI+ E C L+ L + ++S+ ++ L
Sbjct: 376 RKRVLDMEGKD--EELIKMEEQCRDLNKRLE------RETLQSKDFKLEVEKLSKRIMAL 427
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAK-SLRSDKALDLNTKKTTQLEN 895
+ +E + + + SL+ + EK + K+L Q L++ K ++ +A++ +KT E
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT---EF 484
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK-SKQXXXXXXXXXXXXXXXXX 954
LKE L K+K L ++ DE+ +E KK D L+ +
Sbjct: 485 TLKEDLTKLKTLTVMFVDERK----TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEMYVVMKNAGLS 1013
+ LKS D +K + + K+ DL KL+ ++ DL + + +++
Sbjct: 541 EETKRALKSKTDVEEKMYS--VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 598
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K+ K KL ++ + + L + +++ ++ KLKD+ A +E D ++Y
Sbjct: 599 EKDF-LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKA-IEDDLMKTEDEY 656
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+ LE +N ++ + L++E+++ + ++ K K TS
Sbjct: 657 ETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETS 696
Score = 66.5 bits (155), Expect = 9e-10
Identities = 114/581 (19%), Positives = 246/581 (42%), Gaps = 42/581 (7%)
Query: 540 RDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSI 599
++++ E+E + +++ +EE K ++Q +T + E TN+
Sbjct: 209 QEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAK 268
Query: 600 Q-NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNL--RKTA 654
+ + + A +E+ + L + T+ T+FH D + + N + N +K A
Sbjct: 269 ETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLA 328
Query: 655 A--RVEEDNESLLLQLKKMATKARS--RKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
A R ++ E L+K + + K+S N + + ++ D E
Sbjct: 329 ALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEE 388
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L+++ EQ + +R E Q K+ K +V++L+ +I ++ K N + + +
Sbjct: 389 --LIKMEEQCRDLNKRLERETLQSKD-FKLEVEKLSKRIMALEKLEDAFNKSKQECYSLK 445
Query: 771 SNKLAEERV--KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
N L +ER+ K L E++ ++ ++ E E RL + K+ T +K+ ++ D+
Sbjct: 446 CN-LEKERMTTKQLSQELESLKVRIKELEAIESRLE-KTEFTLKEDLTKLKTLTVMFVDE 503
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
+ + +L+ E + L+A + L+ + K+ T +KL + + ++L+S ++
Sbjct: 504 RKT-MSEKLKKTEDK---LQAASSQLQVEQNKVTTVTEKL-IEETKRALKSKTDVEEKMY 558
Query: 889 KTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
T+ ++LK L +E +++ + + +++ EA +K+ K Q
Sbjct: 559 SVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL 618
Query: 947 XXXXXXXXXXXQAT---------LKSLKDDAQKSFKP--RIPKKPTDLTTKLQ-LKKMVE 994
Q +K+++DD K+ + ++ + K Q L K +E
Sbjct: 619 HQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 678
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
++ E+ + + K E + + L K + E +K E K ++ +A
Sbjct: 679 HVKMELAKYKLAEKT------ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT 732
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+D+ L+GD V K EN N +L + + LT+E++
Sbjct: 733 -EDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
Score = 57.2 bits (132), Expect = 6e-07
Identities = 101/528 (19%), Positives = 213/528 (40%), Gaps = 22/528 (4%)
Query: 595 VTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHM--AANNLRK 652
V ++Q A STP ++ + P +DK E+ H + Y I + A + R+
Sbjct: 115 VLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEK---HKE-SYRRILGQLLVAEKSRRQ 170
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMK 711
T +EE+ ++K + + KL + +EKE + E +K
Sbjct: 171 TILELEEEKRKHKEYMEK-SDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLK 229
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV-TKTS-AGSNTTARRSLTT 769
L + A ++ + + L +++++ELT+ TK + A + T
Sbjct: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK-SRSLDASDQ 828
K + + + D + KL ++ +L +L+ ++ L + +RSL +++
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 349
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS-DKALDLNT 887
+ D+K ++ E + + A+ + L L E K +L+K + R +K L+ T
Sbjct: 350 ELQDIKEKISKGEYGNAGIMAEVEELR--KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 888 KKTTQLENELKEALAKIKELEMICQD--EKSEKKVRFTEAT-KKETDTLKSKQXXXXXXX 944
++ + E+++ +I LE + +D KS+++ + +KE T K
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
+ T +LK+D K + T +LKK + L+ ++
Sbjct: 467 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ 526
Query: 1005 VVMKNAGLSGKEMTAKTKLE-KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
V +++ +TK K ++ K+ E + KN+L+ E K D+ +++
Sbjct: 527 VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1064 GDKDVFANKYKALENE--NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
K+ +A+E + + L+ T + +I +LS +++
Sbjct: 587 MLKNRL-QSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
Score = 55.6 bits (128), Expect = 2e-06
Identities = 109/583 (18%), Positives = 232/583 (39%), Gaps = 45/583 (7%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK---DELQARFIKTE 1241
K E++ ++ RVT A+++ + +RL+ +LT ++ EL +T
Sbjct: 212 KSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH 271
Query: 1242 SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDA-LRQTTNDKYDEATSPVEM 1300
+K EA ++ + E K T LE + + Q +D + + TN+ ++
Sbjct: 272 TKLALAEARVQ----EEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKL 327
Query: 1301 VEMR---XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXX 1357
+ ++EL + K K+ K E ++ E+ +L+ + +E
Sbjct: 328 AALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387
Query: 1358 XXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK--DVKNKD-AELATLKG 1414
+ E + + D + E +KL + +A +K D NK E +LK
Sbjct: 388 ELIKMEEQCRDLNKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEH-SLALEKAEY---EELTGKYELLEEEHV 1470
L + K++++ + + +K+LE LEK E+ E+LT K + L V
Sbjct: 447 NL----EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT-KLKTLTVMFV 501
Query: 1471 VTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ ++ + ++ + +L +L ++ T+ EKL E+ KT+++ + S+
Sbjct: 502 DERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
Query: 1531 ERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERV 1590
+ ER D + +L+A ++ + L + D+ +
Sbjct: 562 K---------ER-------DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLK- 604
Query: 1591 SKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQ 1650
+K+ + ++ E+ K ++ D K + M T DE ++L +
Sbjct: 605 NKLNQDSGKSTTALHQENNKIKELSQEVERL-KLKLKDMKAIEDDLMKT-EDEYETLERR 662
Query: 1651 VSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
+ R + + LE + +A+ K +K+ H + +EE K L ++V
Sbjct: 663 YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEE-EAKSGHLSREVDA 721
Query: 1711 LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
L++++ E + L L + S + +L + ++R + E
Sbjct: 722 LKEKIHE-YMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 763
Score = 48.0 bits (109), Expect = 3e-04
Identities = 79/433 (18%), Positives = 183/433 (42%), Gaps = 44/433 (10%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE--RVKVL 782
R+ + ELE++K K+ +++ I + + + + + K E+ RV L
Sbjct: 169 RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTL 228
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKK------------PKTLIKSRSLDASDQQN 830
++E+ +++ + + +RL A+L+L ++K K + + +Q+
Sbjct: 229 KEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 831 VDLKRQLQV----IEQEASVLRAKTQSLEADNEKLQTENKKL-----QLLKNAKSLR-SD 880
L+++LQ Q+ + AK + ++ N +LQ + L +L + +SLR ++
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 881 KALDLNTKKTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
+ L +K ++ E +A+++EL ++ + K E+ ++ E + L+ +
Sbjct: 349 EELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETL 408
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC 998
+ + Q+ + + + +TTK QL + +E L+
Sbjct: 409 QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-QLSQELESLKV 467
Query: 999 EIGEMYVV---MKNAGLSGKEMTAKTK------------LEKEIDEIRSKLSKNDSEFTN 1043
I E+ + ++ + KE K K + +++ + KL S+
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 1044 EKNRLQTEIAKL-KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
E+N++ T KL ++ L+ DV Y ++ E +L N+ K E+ + +++N
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMY-SVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1103 KLSADLKNATSLQ 1115
L L++ +++
Sbjct: 587 MLKNRLQSLEAIE 599
Score = 47.2 bits (107), Expect = 6e-04
Identities = 126/632 (19%), Positives = 253/632 (40%), Gaps = 52/632 (8%)
Query: 267 KEYQDQIEG----LKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
KEY ++ + L+QE + L+K ++ K + + + + T + T S L +
Sbjct: 183 KEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMV 242
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETLC 381
+ LT R + + LT +E ++L EA+ ++ EQ +L +T
Sbjct: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL---AEARVQEEEQKATRLEKELQTQT 299
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ + + + +L + +Q Q DE R L + + + + K+
Sbjct: 300 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGM-QRENRIKELEQEVARSTEVALRLQRELAE 498
K E + E E K++L++ G + + + E + ++L + + R T + + E+ +
Sbjct: 360 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK 419
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
+ + +L K+ + K + + + E + L LE L+ +++
Sbjct: 420 LSKRIM----ALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELE---SLKVRIKE 471
Query: 559 AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ--NKMIHAASTPSSKEKS 616
E + ++ T + + + E +T++ ++ + AAS+ E++
Sbjct: 472 LEAIESRLEKTE-FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 530
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
++ +K EET+ + ++ + V ++ + L +LK K
Sbjct: 531 KVTTVT-EKLIEETKRAL----------KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
Query: 677 SRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
N+L S+E + K D + L QE K++EL Q+
Sbjct: 580 DLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL---HQE----NNKIKELSQEV 632
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK-KLI 794
E LK ++K++ + + KT T RR N A+ K LE E+ K KL
Sbjct: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERR--YANERDKAQFLSKELEHVKMELAKYKLA 690
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI---EQEASVLRAKT 851
EK L +++ K+ SR +DA ++ + +I + + SVL+ K
Sbjct: 691 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL 750
Query: 852 QSLEADNEKL--QTEN--KKLQLLKN-AKSLR 878
E N L + EN K+L+ ++ +KSLR
Sbjct: 751 NQQENRNRDLGREIENLTKELERYRHFSKSLR 782
Score = 44.4 bits (100), Expect = 0.004
Identities = 65/315 (20%), Positives = 126/315 (40%), Gaps = 13/315 (4%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+N KE ++ + V ++ R+EKE + + DT T S+ +LQ
Sbjct: 265 TNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ 324
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE----AQTRQIEQLRAKLLAAET 379
QK+ L+ ++L + + L + E++ E E ++E+LR ++L E
Sbjct: 325 QKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEG 384
Query: 380 LCEEL--MDEN-EDMKKEL--RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
EEL M+E D+ K L L ++ + L ++ + C L
Sbjct: 385 KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL 444
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQ 493
L+K QL QE + ++ E+ +++ E +KE ++ T + + +
Sbjct: 445 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
+ ++E K + Q E KV+ + + + D+++ + R
Sbjct: 505 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 564
Query: 554 EQLRN---AEEETAN 565
+ L+N AEEE N
Sbjct: 565 DDLKNKLKAEEEKGN 579
Score = 41.5 bits (93), Expect = 0.030
Identities = 93/539 (17%), Positives = 195/539 (36%), Gaps = 36/539 (6%)
Query: 1015 KEMTAKTKLEKE-IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ +TA+ L+++ I E+ + + ++ + R+Q E K + +L+ F
Sbjct: 247 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
+ + +N +Q + L +++ QI++L ++ + + D
Sbjct: 307 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA 366
Query: 1134 XXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQ--- 1190
+V + D++ K+ ++ D K++ +++ K+
Sbjct: 367 GIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMA 426
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTS------EKDELQARFIKTE--- 1241
L +D T ++LS EL S E + +++R KTE
Sbjct: 427 LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTL 486
Query: 1242 ----SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSP 1297
+K TL D + K+ E + A + Q+E T +K E T
Sbjct: 487 KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL-QVEQNKVTTVTEKLIEETK- 544
Query: 1298 VEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLK-SDLAKLENXX 1356
++ + +D+L N K+K E+ + +++ M + + L +E
Sbjct: 545 -RALKSKTDVEEKMYSVTKERDDLKN-KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF 602
Query: 1357 XXXXXXXXXXXXXSSYWE--NKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKG 1414
++ + NK KEL +++ + KL M+ D +K +D
Sbjct: 603 LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTED-------- 654
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVT-- 1472
+ + LE+ + L +E E +L EK E ++ L+EE +
Sbjct: 655 EYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGH 714
Query: 1473 -KARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ KE+ E + + + G+ LQ+KL + E++N L+
Sbjct: 715 LSREVDALKEKIH-EYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
Score = 37.1 bits (82), Expect = 0.64
Identities = 49/224 (21%), Positives = 98/224 (43%), Gaps = 21/224 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK---- 321
+++ +D KQE L+ E+ E+ + L + L ++ K S + K
Sbjct: 427 LEKLEDAFNKSKQECYSLKCNLEK-ERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 485
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L++ + +L T DE+K +++K+++ E +L+ S Q+EQ + T+
Sbjct: 486 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQ----LQVEQNKVT-----TVT 536
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+L++E + K D+ + R+D ++ + + + +L +L+
Sbjct: 537 EKLIEETKRALKSKTDVEEKMYSVTKE-RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL 595
Query: 442 ER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
E + D L+ + + K + Q N+IKEL QEV R
Sbjct: 596 EAIEKDFLKNKLNQDSGKSTTALH-----QENNKIKELSQEVER 634
>AF514868-1|AAQ08178.1| 1133|Homo sapiens GPBP-interacting protein
130b protein.
Length = 1133
Score = 66.9 bits (156), Expect = 7e-10
Identities = 87/400 (21%), Positives = 179/400 (44%), Gaps = 31/400 (7%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE 777
+Q+ L R+++ELE+ +L+K +EL ++K G+ ++ E
Sbjct: 324 QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA--------EVEEL 375
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R +VL+ E + ++LI+ E C L+ L + ++S+ ++ L
Sbjct: 376 RKRVLDMEGKD--EELIKMEEQCRDLNKRLE------RETLQSKDFKLEVEKLSKRIMAL 427
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAK-SLRSDKALDLNTKKTTQLEN 895
+ +E + + + SL+ + EK + K+L Q L++ K ++ +A++ +KT E
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT---EF 484
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK-SKQXXXXXXXXXXXXXXXXX 954
LKE L K+K L ++ DE+ +E KK D L+ +
Sbjct: 485 TLKEDLTKLKTLTVMFVDERK----TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEMYVVMKNAGLS 1013
+ LKS D +K + + K+ DL KL+ ++ DL + + +++
Sbjct: 541 EETKRALKSKTDVEEKMYS--VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 598
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K+ K KL ++ + + L + +++ ++ KLKD+ A +E D ++Y
Sbjct: 599 EKDF-LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKA-IEDDLMKTEDEY 656
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+ LE +N ++ + L++E+++ + ++ K K TS
Sbjct: 657 ETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETS 696
Score = 66.5 bits (155), Expect = 9e-10
Identities = 114/581 (19%), Positives = 246/581 (42%), Gaps = 42/581 (7%)
Query: 540 RDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSI 599
++++ E+E + +++ +EE K ++Q +T + E TN+
Sbjct: 209 QEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAK 268
Query: 600 Q-NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNL--RKTA 654
+ + + A +E+ + L + T+ T+FH D + + N + N +K A
Sbjct: 269 ETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLA 328
Query: 655 A--RVEEDNESLLLQLKKMATKARS--RKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
A R ++ E L+K + + K+S N + + ++ D E
Sbjct: 329 ALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEE 388
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L+++ EQ + +R E Q K+ K +V++L+ +I ++ K N + + +
Sbjct: 389 --LIKMEEQCRDLNKRLERETLQSKD-FKLEVEKLSKRIMALEKLEDAFNKSKQECYSLK 445
Query: 771 SNKLAEERV--KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
N L +ER+ K L E++ ++ ++ E E RL + K+ T +K+ ++ D+
Sbjct: 446 CN-LEKERMTTKQLSQELESLKVRIKELEAIESRLE-KTEFTLKEDLTKLKTLTVMFVDE 503
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
+ + +L+ E + L+A + L+ + K+ T +KL + + ++L+S ++
Sbjct: 504 RKT-MSEKLKKTEDK---LQAASSQLQVEQNKVTTVTEKL-IEETKRALKSKTDVEEKMY 558
Query: 889 KTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
T+ ++LK L +E +++ + + +++ EA +K+ K Q
Sbjct: 559 SVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL 618
Query: 947 XXXXXXXXXXXQAT---------LKSLKDDAQKSFKP--RIPKKPTDLTTKLQ-LKKMVE 994
Q +K+++DD K+ + ++ + K Q L K +E
Sbjct: 619 HQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 678
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
++ E+ + + K E + + L K + E +K E K ++ +A
Sbjct: 679 HVKMELAKYKLAEKT------ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT 732
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+D+ L+GD V K EN N +L + + LT+E++
Sbjct: 733 -EDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
Score = 56.8 bits (131), Expect = 7e-07
Identities = 101/528 (19%), Positives = 213/528 (40%), Gaps = 22/528 (4%)
Query: 595 VTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHM--AANNLRK 652
V ++Q A STP ++ + P +DK E+ H + Y I + A + R+
Sbjct: 115 VLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEK---HKE-SYRRILGQLLVAEKSHRQ 170
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMK 711
T +EE+ ++K + + KL + +EKE + E +K
Sbjct: 171 TILELEEEKRKHKEYMEK-SDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLK 229
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV-TKTS-AGSNTTARRSLTT 769
L + A ++ + + L +++++ELT+ TK + A + T
Sbjct: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK-SRSLDASDQ 828
K + + + D + KL ++ +L +L+ ++ L + +RSL +++
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 349
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS-DKALDLNT 887
+ D+K ++ E + + A+ + L L E K +L+K + R +K L+ T
Sbjct: 350 ELQDIKEKISKGEYGNAGIMAEVEELR--KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 888 KKTTQLENELKEALAKIKELEMICQD--EKSEKKVRFTEAT-KKETDTLKSKQXXXXXXX 944
++ + E+++ +I LE + +D KS+++ + +KE T K
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
+ T +LK+D K + T +LKK + L+ ++
Sbjct: 467 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ 526
Query: 1005 VVMKNAGLSGKEMTAKTKLE-KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
V +++ +TK K ++ K+ E + KN+L+ E K D+ +++
Sbjct: 527 VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1064 GDKDVFANKYKALENE--NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
K+ +A+E + + L+ T + +I +LS +++
Sbjct: 587 MLKNRL-QSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
Score = 55.6 bits (128), Expect = 2e-06
Identities = 109/583 (18%), Positives = 232/583 (39%), Gaps = 45/583 (7%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK---DELQARFIKTE 1241
K E++ ++ RVT A+++ + +RL+ +LT ++ EL +T
Sbjct: 212 KSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH 271
Query: 1242 SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDA-LRQTTNDKYDEATSPVEM 1300
+K EA ++ + E K T LE + + Q +D + + TN+ ++
Sbjct: 272 TKLALAEARVQ----EEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKL 327
Query: 1301 VEMR---XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXX 1357
+ ++EL + K K+ K E ++ E+ +L+ + +E
Sbjct: 328 AALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387
Query: 1358 XXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK--DVKNKD-AELATLKG 1414
+ E + + D + E +KL + +A +K D NK E +LK
Sbjct: 388 ELIKMEEQCRDLNKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEH-SLALEKAEY---EELTGKYELLEEEHV 1470
L + K++++ + + +K+LE LEK E+ E+LT K + L V
Sbjct: 447 NL----EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT-KLKTLTVMFV 501
Query: 1471 VTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ ++ + ++ + +L +L ++ T+ EKL E+ KT+++ + S+
Sbjct: 502 DERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
Query: 1531 ERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERV 1590
+ ER D + +L+A ++ + L + D+ +
Sbjct: 562 K---------ER-------DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLK- 604
Query: 1591 SKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQ 1650
+K+ + ++ E+ K ++ D K + M T DE ++L +
Sbjct: 605 NKLNQDSGKSTTALHQENNKIKELSQEVERL-KLKLKDMKAIEDDLMKT-EDEYETLERR 662
Query: 1651 VSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
+ R + + LE + +A+ K +K+ H + +EE K L ++V
Sbjct: 663 YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEE-EAKSGHLSREVDA 721
Query: 1711 LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
L++++ E + L L + S + +L + ++R + E
Sbjct: 722 LKEKIHE-YMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 763
Score = 48.0 bits (109), Expect = 3e-04
Identities = 79/433 (18%), Positives = 183/433 (42%), Gaps = 44/433 (10%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE--RVKVL 782
R+ + ELE++K K+ +++ I + + + + + K E+ RV L
Sbjct: 169 RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTL 228
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKK------------PKTLIKSRSLDASDQQN 830
++E+ +++ + + +RL A+L+L ++K K + + +Q+
Sbjct: 229 KEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 831 VDLKRQLQV----IEQEASVLRAKTQSLEADNEKLQTENKKL-----QLLKNAKSLR-SD 880
L+++LQ Q+ + AK + ++ N +LQ + L +L + +SLR ++
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 881 KALDLNTKKTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
+ L +K ++ E +A+++EL ++ + K E+ ++ E + L+ +
Sbjct: 349 EELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETL 408
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC 998
+ + Q+ + + + +TTK QL + +E L+
Sbjct: 409 QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-QLSQELESLKV 467
Query: 999 EIGEMYVV---MKNAGLSGKEMTAKTK------------LEKEIDEIRSKLSKNDSEFTN 1043
I E+ + ++ + KE K K + +++ + KL S+
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 1044 EKNRLQTEIAKL-KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
E+N++ T KL ++ L+ DV Y ++ E +L N+ K E+ + +++N
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMY-SVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1103 KLSADLKNATSLQ 1115
L L++ +++
Sbjct: 587 MLKNRLQSLEAIE 599
Score = 47.2 bits (107), Expect = 6e-04
Identities = 126/632 (19%), Positives = 253/632 (40%), Gaps = 52/632 (8%)
Query: 267 KEYQDQIEG----LKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
KEY ++ + L+QE + L+K ++ K + + + + T + T S L +
Sbjct: 183 KEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMV 242
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETLC 381
+ LT R + + LT +E ++L EA+ ++ EQ +L +T
Sbjct: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL---AEARVQEEEQKATRLEKELQTQT 299
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ + + + +L + +Q Q DE R L + + + + K+
Sbjct: 300 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGM-QRENRIKELEQEVARSTEVALRLQRELAE 498
K E + E E K++L++ G + + + E + ++L + + R T + + E+ +
Sbjct: 360 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK 419
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
+ + +L K+ + K + + + E + L LE L+ +++
Sbjct: 420 LSKRIM----ALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELE---SLKVRIKE 471
Query: 559 AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ--NKMIHAASTPSSKEKS 616
E + ++ T + + + E +T++ ++ + AAS+ E++
Sbjct: 472 LEAIESRLEKTE-FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 530
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
++ +K EET+ + ++ + V ++ + L +LK K
Sbjct: 531 KVTTVT-EKLIEETKRAL----------KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
Query: 677 SRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
N+L S+E + K D + L QE K++EL Q+
Sbjct: 580 DLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL---HQE----NNKIKELSQEV 632
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK-KLI 794
E LK ++K++ + + KT T RR N A+ K LE E+ K KL
Sbjct: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERR--YANERDKAQFLSKELEHVKMELAKYKLA 690
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI---EQEASVLRAKT 851
EK L +++ K+ SR +DA ++ + +I + + SVL+ K
Sbjct: 691 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL 750
Query: 852 QSLEADNEKL--QTEN--KKLQLLKN-AKSLR 878
E N L + EN K+L+ ++ +KSLR
Sbjct: 751 NQQENRNRDLGREIENLTKELERYRHFSKSLR 782
Score = 44.4 bits (100), Expect = 0.004
Identities = 65/315 (20%), Positives = 126/315 (40%), Gaps = 13/315 (4%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+N KE ++ + V ++ R+EKE + + DT T S+ +LQ
Sbjct: 265 TNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ 324
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE----AQTRQIEQLRAKLLAAET 379
QK+ L+ ++L + + L + E++ E E ++E+LR ++L E
Sbjct: 325 QKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEG 384
Query: 380 LCEEL--MDEN-EDMKKEL--RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
EEL M+E D+ K L L ++ + L ++ + C L
Sbjct: 385 KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL 444
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQ 493
L+K QL QE + ++ E+ +++ E +KE ++ T + + +
Sbjct: 445 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
+ ++E K + Q E KV+ + + + D+++ + R
Sbjct: 505 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 564
Query: 554 EQLRN---AEEETAN 565
+ L+N AEEE N
Sbjct: 565 DDLKNKLKAEEEKGN 579
Score = 43.6 bits (98), Expect = 0.007
Identities = 107/583 (18%), Positives = 222/583 (38%), Gaps = 46/583 (7%)
Query: 1211 QAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIA 1270
Q +V +HR+ +EL EK + + K++ LE E LK + +I S E
Sbjct: 160 QLLVAEKSHRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQ 219
Query: 1271 AKDVHIKQLEDALRQTTN------DKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNA 1324
K+ + L++ L + + D+ T+ + + + + L A
Sbjct: 220 EKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEA 279
Query: 1325 KIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDL 1384
+++ E E A +LE +L++ K +++ ++L L
Sbjct: 280 RVQ----EEEQKATRLE-KELQTQTTKFHQDQDTIMAKLTNE-------DSQNRQLQQKL 327
Query: 1385 QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKL 1444
+ +++D + ++ ++ + EL +K K+ E + + EL++ + K
Sbjct: 328 AALSRQIDELE-ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKD 386
Query: 1445 EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTL 1504
E + +E E+ + LE E + +K +E E+ ++ ++K L A + K
Sbjct: 387 EELIKME----EQCRDLNKRLERETLQSK-DFKLEVEKLSKRIMALEK-LEDAFNKSKQE 440
Query: 1505 QEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRD 1564
L ++ + SL+ R+ E + +RL++ E L+ +
Sbjct: 441 CYSLKCNLEKERMTTKQLSQELESLKVRI------KELEAIESRLEKTEFTLKEDLTKLK 494
Query: 1565 VLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKA 1624
L D K+Q IE++++A K+
Sbjct: 495 TLTVMFVDERKTMSEKLKKTED-----KLQAASSQLQVEQNKVTTVTEKLIEETKRALKS 549
Query: 1625 EITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARI 1684
+ TD + + + RD+LK+ + + ML+ +S+ I+ ++
Sbjct: 550 K-TDVEEKMY-SVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 607
Query: 1685 HRNSISSTDE-EEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEM 1743
+++S ST + NK+ L Q+V L+ +L + + + L + E + E R A
Sbjct: 608 NQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDL-MKTEDEYETLERRYA-- 664
Query: 1744 QSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQ 1786
NE ++ + LS V + +LA E +Q L +
Sbjct: 665 ----NERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFK 703
Score = 41.5 bits (93), Expect = 0.030
Identities = 93/539 (17%), Positives = 195/539 (36%), Gaps = 36/539 (6%)
Query: 1015 KEMTAKTKLEKE-IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ +TA+ L+++ I E+ + + ++ + R+Q E K + +L+ F
Sbjct: 247 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
+ + +N +Q + L +++ QI++L ++ + + D
Sbjct: 307 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA 366
Query: 1134 XXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQ--- 1190
+V + D++ K+ ++ D K++ +++ K+
Sbjct: 367 GIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMA 426
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTS------EKDELQARFIKTE--- 1241
L +D T ++LS EL S E + +++R KTE
Sbjct: 427 LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTL 486
Query: 1242 ----SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSP 1297
+K TL D + K+ E + A + Q+E T +K E T
Sbjct: 487 KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL-QVEQNKVTTVTEKLIEETK- 544
Query: 1298 VEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLK-SDLAKLENXX 1356
++ + +D+L N K+K E+ + +++ M + + L +E
Sbjct: 545 -RALKSKTDVEEKMYSVTKERDDLKN-KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF 602
Query: 1357 XXXXXXXXXXXXXSSYWE--NKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKG 1414
++ + NK KEL +++ + KL M+ D +K +D
Sbjct: 603 LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTED-------- 654
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVT-- 1472
+ + LE+ + L +E E +L EK E ++ L+EE +
Sbjct: 655 EYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGH 714
Query: 1473 -KARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ KE+ E + + + G+ LQ+KL + E++N L+
Sbjct: 715 LSREVDALKEKIH-EYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
Score = 37.1 bits (82), Expect = 0.64
Identities = 49/224 (21%), Positives = 98/224 (43%), Gaps = 21/224 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK---- 321
+++ +D KQE L+ E+ E+ + L + L ++ K S + K
Sbjct: 427 LEKLEDAFNKSKQECYSLKCNLEK-ERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 485
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L++ + +L T DE+K +++K+++ E +L+ S Q+EQ + T+
Sbjct: 486 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQ----LQVEQNKVT-----TVT 536
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+L++E + K D+ + R+D ++ + + + +L +L+
Sbjct: 537 EKLIEETKRALKSKTDVEEKMYSVTKE-RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL 595
Query: 442 ER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
E + D L+ + + K + Q N+IKEL QEV R
Sbjct: 596 EAIEKDFLKNKLNQDSGKSTTALH-----QENNKIKELSQEVER 634
>AF514867-1|AAQ08177.1| 1135|Homo sapiens GPBP-interacting protein
130a protein.
Length = 1135
Score = 66.9 bits (156), Expect = 7e-10
Identities = 87/400 (21%), Positives = 179/400 (44%), Gaps = 31/400 (7%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE 777
+Q+ L R+++ELE+ +L+K +EL ++K G+ ++ E
Sbjct: 324 QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA--------EVEEL 375
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R +VL+ E + ++LI+ E C L+ L + ++S+ ++ L
Sbjct: 376 RKRVLDMEGKD--EELIKMEEQCRDLNKRLE------RETLQSKDFKLEVEKLSKRIMAL 427
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAK-SLRSDKALDLNTKKTTQLEN 895
+ +E + + + SL+ + EK + K+L Q L++ K ++ +A++ +KT E
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT---EF 484
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK-SKQXXXXXXXXXXXXXXXXX 954
LKE L K+K L ++ DE+ +E KK D L+ +
Sbjct: 485 TLKEDLTKLKTLTVMFVDERK----TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEMYVVMKNAGLS 1013
+ LKS D +K + + K+ DL KL+ ++ DL + + +++
Sbjct: 541 EETKRALKSKTDVEEKMYS--VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 598
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K+ K KL ++ + + L + +++ ++ KLKD+ A +E D ++Y
Sbjct: 599 EKDF-LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKA-IEDDLMKTEDEY 656
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+ LE +N ++ + L++E+++ + ++ K K TS
Sbjct: 657 ETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETS 696
Score = 66.5 bits (155), Expect = 9e-10
Identities = 114/581 (19%), Positives = 246/581 (42%), Gaps = 42/581 (7%)
Query: 540 RDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSI 599
++++ E+E + +++ +EE K ++Q +T + E TN+
Sbjct: 209 QEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAK 268
Query: 600 Q-NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL--SIFNHMAANNL--RKTA 654
+ + + A +E+ + L + T+ T+FH D + + N + N +K A
Sbjct: 269 ETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLA 328
Query: 655 A--RVEEDNESLLLQLKKMATKARS--RKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
A R ++ E L+K + + K+S N + + ++ D E
Sbjct: 329 ALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEE 388
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
L+++ EQ + +R E Q K+ K +V++L+ +I ++ K N + + +
Sbjct: 389 --LIKMEEQCRDLNKRLERETLQSKD-FKLEVEKLSKRIMALEKLEDAFNKSKQECYSLK 445
Query: 771 SNKLAEERV--KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
N L +ER+ K L E++ ++ ++ E E RL + K+ T +K+ ++ D+
Sbjct: 446 CN-LEKERMTTKQLSQELESLKVRIKELEAIESRLE-KTEFTLKEDLTKLKTLTVMFVDE 503
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
+ + +L+ E + L+A + L+ + K+ T +KL + + ++L+S ++
Sbjct: 504 RKT-MSEKLKKTEDK---LQAASSQLQVEQNKVTTVTEKL-IEETKRALKSKTDVEEKMY 558
Query: 889 KTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXX 946
T+ ++LK L +E +++ + + +++ EA +K+ K Q
Sbjct: 559 SVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL 618
Query: 947 XXXXXXXXXXXQAT---------LKSLKDDAQKSFKP--RIPKKPTDLTTKLQ-LKKMVE 994
Q +K+++DD K+ + ++ + K Q L K +E
Sbjct: 619 HQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 678
Query: 995 DLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
++ E+ + + K E + + L K + E +K E K ++ +A
Sbjct: 679 HVKMELAKYKLAEKT------ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT 732
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMK 1095
+D+ L+GD V K EN N +L + + LT+E++
Sbjct: 733 -EDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
Score = 57.2 bits (132), Expect = 6e-07
Identities = 101/528 (19%), Positives = 213/528 (40%), Gaps = 22/528 (4%)
Query: 595 VTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHM--AANNLRK 652
V ++Q A STP ++ + P +DK E+ H + Y I + A + R+
Sbjct: 115 VLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEK---HKE-SYRRILGQLLVAEKSRRQ 170
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMK 711
T +EE+ ++K + + KL + +EKE + E +K
Sbjct: 171 TILELEEEKRKHKEYMEK-SDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLK 229
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV-TKTS-AGSNTTARRSLTT 769
L + A ++ + + L +++++ELT+ TK + A + T
Sbjct: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK-SRSLDASDQ 828
K + + + D + KL ++ +L +L+ ++ L + +RSL +++
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 349
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS-DKALDLNT 887
+ D+K ++ E + + A+ + L L E K +L+K + R +K L+ T
Sbjct: 350 ELQDIKEKISKGEYGNAGIMAEVEELR--KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 888 KKTTQLENELKEALAKIKELEMICQD--EKSEKKVRFTEAT-KKETDTLKSKQXXXXXXX 944
++ + E+++ +I LE + +D KS+++ + +KE T K
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
+ T +LK+D K + T +LKK + L+ ++
Sbjct: 467 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ 526
Query: 1005 VVMKNAGLSGKEMTAKTKLE-KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
V +++ +TK K ++ K+ E + KN+L+ E K D+ +++
Sbjct: 527 VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1064 GDKDVFANKYKALENE--NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
K+ +A+E + + L+ T + +I +LS +++
Sbjct: 587 MLKNRL-QSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
Score = 55.6 bits (128), Expect = 2e-06
Identities = 109/583 (18%), Positives = 232/583 (39%), Gaps = 45/583 (7%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK---DELQARFIKTE 1241
K E++ ++ RVT A+++ + +RL+ +LT ++ EL +T
Sbjct: 212 KSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH 271
Query: 1242 SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDA-LRQTTNDKYDEATSPVEM 1300
+K EA ++ + E K T LE + + Q +D + + TN+ ++
Sbjct: 272 TKLALAEARVQ----EEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKL 327
Query: 1301 VEMR---XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXX 1357
+ ++EL + K K+ K E ++ E+ +L+ + +E
Sbjct: 328 AALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387
Query: 1358 XXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK--DVKNKD-AELATLKG 1414
+ E + + D + E +KL + +A +K D NK E +LK
Sbjct: 388 ELIKMEEQCRDLNKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEH-SLALEKAEY---EELTGKYELLEEEHV 1470
L + K++++ + + +K+LE LEK E+ E+LT K + L V
Sbjct: 447 NL----EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT-KLKTLTVMFV 501
Query: 1471 VTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ ++ + ++ + +L +L ++ T+ EKL E+ KT+++ + S+
Sbjct: 502 DERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
Query: 1531 ERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERV 1590
+ ER D + +L+A ++ + L + D+ +
Sbjct: 562 K---------ER-------DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLK- 604
Query: 1591 SKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQ 1650
+K+ + ++ E+ K ++ D K + M T DE ++L +
Sbjct: 605 NKLNQDSGKSTTALHQENNKIKELSQEVERL-KLKLKDMKAIEDDLMKT-EDEYETLERR 662
Query: 1651 VSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
+ R + + LE + +A+ K +K+ H + +EE K L ++V
Sbjct: 663 YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEE-EAKSGHLSREVDA 721
Query: 1711 LEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEE 1753
L++++ E + L L + S + +L + ++R + E
Sbjct: 722 LKEKIHE-YMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 763
Score = 48.0 bits (109), Expect = 3e-04
Identities = 79/433 (18%), Positives = 183/433 (42%), Gaps = 44/433 (10%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE--RVKVL 782
R+ + ELE++K K+ +++ I + + + + + K E+ RV L
Sbjct: 169 RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTL 228
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKK------------PKTLIKSRSLDASDQQN 830
++E+ +++ + + +RL A+L+L ++K K + + +Q+
Sbjct: 229 KEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 831 VDLKRQLQV----IEQEASVLRAKTQSLEADNEKLQTENKKL-----QLLKNAKSLR-SD 880
L+++LQ Q+ + AK + ++ N +LQ + L +L + +SLR ++
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 881 KALDLNTKKTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
+ L +K ++ E +A+++EL ++ + K E+ ++ E + L+ +
Sbjct: 349 EELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETL 408
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC 998
+ + Q+ + + + +TTK QL + +E L+
Sbjct: 409 QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-QLSQELESLKV 467
Query: 999 EIGEMYVV---MKNAGLSGKEMTAKTK------------LEKEIDEIRSKLSKNDSEFTN 1043
I E+ + ++ + KE K K + +++ + KL S+
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 1044 EKNRLQTEIAKL-KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
E+N++ T KL ++ L+ DV Y ++ E +L N+ K E+ + +++N
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMY-SVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1103 KLSADLKNATSLQ 1115
L L++ +++
Sbjct: 587 MLKNRLQSLEAIE 599
Score = 47.2 bits (107), Expect = 6e-04
Identities = 126/632 (19%), Positives = 253/632 (40%), Gaps = 52/632 (8%)
Query: 267 KEYQDQIEG----LKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
KEY ++ + L+QE + L+K ++ K + + + + T + T S L +
Sbjct: 183 KEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMV 242
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETLC 381
+ LT R + + LT +E ++L EA+ ++ EQ +L +T
Sbjct: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL---AEARVQEEEQKATRLEKELQTQT 299
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ + + + +L + +Q Q DE R L + + + + K+
Sbjct: 300 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGM-QRENRIKELEQEVARSTEVALRLQRELAE 498
K E + E E K++L++ G + + + E + ++L + + R T + + E+ +
Sbjct: 360 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK 419
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
+ + +L K+ + K + + + E + L LE L+ +++
Sbjct: 420 LSKRIM----ALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELE---SLKVRIKE 471
Query: 559 AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ--NKMIHAASTPSSKEKS 616
E + ++ T + + + E +T++ ++ + AAS+ E++
Sbjct: 472 LEAIESRLEKTE-FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 530
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
++ +K EET+ + ++ + V ++ + L +LK K
Sbjct: 531 KVTTVT-EKLIEETKRAL----------KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
Query: 677 SRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
N+L S+E + K D + L QE K++EL Q+
Sbjct: 580 DLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL---HQE----NNKIKELSQEV 632
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK-KLI 794
E LK ++K++ + + KT T RR N A+ K LE E+ K KL
Sbjct: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERR--YANERDKAQFLSKELEHVKMELAKYKLA 690
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI---EQEASVLRAKT 851
EK L +++ K+ SR +DA ++ + +I + + SVL+ K
Sbjct: 691 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL 750
Query: 852 QSLEADNEKL--QTEN--KKLQLLKN-AKSLR 878
E N L + EN K+L+ ++ +KSLR
Sbjct: 751 NQQENRNRDLGREIENLTKELERYRHFSKSLR 782
Score = 44.4 bits (100), Expect = 0.004
Identities = 65/315 (20%), Positives = 126/315 (40%), Gaps = 13/315 (4%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+N KE ++ + V ++ R+EKE + + DT T S+ +LQ
Sbjct: 265 TNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ 324
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE----AQTRQIEQLRAKLLAAET 379
QK+ L+ ++L + + L + E++ E E ++E+LR ++L E
Sbjct: 325 QKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEG 384
Query: 380 LCEEL--MDEN-EDMKKEL--RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
EEL M+E D+ K L L ++ + L ++ + C L
Sbjct: 385 KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL 444
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQ 493
L+K QL QE + ++ E+ +++ E +KE ++ T + + +
Sbjct: 445 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
+ ++E K + Q E KV+ + + + D+++ + R
Sbjct: 505 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 564
Query: 554 EQLRN---AEEETAN 565
+ L+N AEEE N
Sbjct: 565 DDLKNKLKAEEEKGN 579
Score = 41.5 bits (93), Expect = 0.030
Identities = 93/539 (17%), Positives = 195/539 (36%), Gaps = 36/539 (6%)
Query: 1015 KEMTAKTKLEKE-IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
+ +TA+ L+++ I E+ + + ++ + R+Q E K + +L+ F
Sbjct: 247 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
+ + +N +Q + L +++ QI++L ++ + + D
Sbjct: 307 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA 366
Query: 1134 XXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQ--- 1190
+V + D++ K+ ++ D K++ +++ K+
Sbjct: 367 GIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMA 426
Query: 1191 LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTS------EKDELQARFIKTE--- 1241
L +D T ++LS EL S E + +++R KTE
Sbjct: 427 LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTL 486
Query: 1242 ----SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSP 1297
+K TL D + K+ E + A + Q+E T +K E T
Sbjct: 487 KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL-QVEQNKVTTVTEKLIEETK- 544
Query: 1298 VEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLK-SDLAKLENXX 1356
++ + +D+L N K+K E+ + +++ M + + L +E
Sbjct: 545 -RALKSKTDVEEKMYSVTKERDDLKN-KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF 602
Query: 1357 XXXXXXXXXXXXXSSYWE--NKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKG 1414
++ + NK KEL +++ + KL M+ D +K +D
Sbjct: 603 LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTED-------- 654
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVT-- 1472
+ + LE+ + L +E E +L EK E ++ L+EE +
Sbjct: 655 EYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGH 714
Query: 1473 -KARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ KE+ E + + + G+ LQ+KL + E++N L+
Sbjct: 715 LSREVDALKEKIH-EYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
Score = 37.1 bits (82), Expect = 0.64
Identities = 49/224 (21%), Positives = 98/224 (43%), Gaps = 21/224 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK---- 321
+++ +D KQE L+ E+ E+ + L + L ++ K S + K
Sbjct: 427 LEKLEDAFNKSKQECYSLKCNLEK-ERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 485
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L++ + +L T DE+K +++K+++ E +L+ S Q+EQ + T+
Sbjct: 486 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQ----LQVEQNKVT-----TVT 536
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+L++E + K D+ + R+D ++ + + + +L +L+
Sbjct: 537 EKLIEETKRALKSKTDVEEKMYSVTKE-RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL 595
Query: 442 ER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
E + D L+ + + K + Q N+IKEL QEV R
Sbjct: 596 EAIEKDFLKNKLNQDSGKSTTALH-----QENNKIKELSQEVER 634
>AF329092-1|AAN16206.1| 764|Homo sapiens GPBP-interacting protein 90
protein.
Length = 764
Score = 66.9 bits (156), Expect = 7e-10
Identities = 87/400 (21%), Positives = 179/400 (44%), Gaps = 31/400 (7%)
Query: 718 EQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE 777
+Q+ L R+++ELE+ +L+K +EL ++K G+ ++ E
Sbjct: 324 QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA--------EVEEL 375
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL 837
R +VL+ E + ++LI+ E C L+ L + ++S+ ++ L
Sbjct: 376 RKRVLDMEGKD--EELIKMEEQCRDLNKRLE------RETLQSKDFKLEVEKLSKRIMAL 427
Query: 838 QVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAK-SLRSDKALDLNTKKTTQLEN 895
+ +E + + + SL+ + EK + K+L Q L++ K ++ +A++ +KT E
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT---EF 484
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLK-SKQXXXXXXXXXXXXXXXXX 954
LKE L K+K L ++ DE+ +E KK D L+ +
Sbjct: 485 TLKEDLTKLKTLTVMFVDERK----TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL-KKMVEDLECEIGEMYVVMKNAGLS 1013
+ LKS D +K + + K+ DL KL+ ++ DL + + +++
Sbjct: 541 EETKRALKSKTDVEEKMYS--VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 598
Query: 1014 GKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKY 1073
K+ K KL ++ + + L + +++ ++ KLKD+ A +E D ++Y
Sbjct: 599 EKDF-LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKA-IEDDLMKTEDEY 656
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+ LE +N ++ + L++E+++ + ++ K K TS
Sbjct: 657 ETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETS 696
Score = 57.2 bits (132), Expect = 6e-07
Identities = 101/528 (19%), Positives = 213/528 (40%), Gaps = 22/528 (4%)
Query: 595 VTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHM--AANNLRK 652
V ++Q A STP ++ + P +DK E+ H + Y I + A + R+
Sbjct: 115 VLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEK---HKE-SYRRILGQLLVAEKSRRQ 170
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD-EADPAEMK 711
T +EE+ ++K + + KL + +EKE + E +K
Sbjct: 171 TILELEEEKRKHKEYMEK-SDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLK 229
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV-TKTS-AGSNTTARRSLTT 769
L + A ++ + + L +++++ELT+ TK + A + T
Sbjct: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK-SRSLDASDQ 828
K + + + D + KL ++ +L +L+ ++ L + +RSL +++
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 349
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRS-DKALDLNT 887
+ D+K ++ E + + A+ + L L E K +L+K + R +K L+ T
Sbjct: 350 ELQDIKEKISKGEYGNAGIMAEVEELR--KRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 888 KKTTQLENELKEALAKIKELEMICQD--EKSEKKVRFTEAT-KKETDTLKSKQXXXXXXX 944
++ + E+++ +I LE + +D KS+++ + +KE T K
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
+ T +LK+D K + T +LKK + L+ ++
Sbjct: 467 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ 526
Query: 1005 VVMKNAGLSGKEMTAKTKLE-KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
V +++ +TK K ++ K+ E + KN+L+ E K D+ +++
Sbjct: 527 VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1064 GDKDVFANKYKALENE--NSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
K+ +A+E + + L+ T + +I +LS +++
Sbjct: 587 MLKNRL-QSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
Score = 53.2 bits (122), Expect = 9e-06
Identities = 103/547 (18%), Positives = 218/547 (39%), Gaps = 44/547 (8%)
Query: 1185 KRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEK---DELQARFIKTE 1241
K E++ ++ RVT A+++ + +RL+ +LT ++ EL +T
Sbjct: 212 KSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH 271
Query: 1242 SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDA-LRQTTNDKYDEATSPVEM 1300
+K EA ++ + E K T LE + + Q +D + + TN+ ++
Sbjct: 272 TKLALAEARVQ----EEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKL 327
Query: 1301 VEMR---XXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXX 1357
+ ++EL + K K+ K E ++ E+ +L+ + +E
Sbjct: 328 AALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387
Query: 1358 XXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDK--DVKNKD-AELATLKG 1414
+ E + + D + E +KL + +A +K D NK E +LK
Sbjct: 388 ELIKMEEQCRDLNKRLERETLQ-SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKC 446
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEH-SLALEKAEY---EELTGKYELLEEEHV 1470
L + K++++ + + +K+LE LEK E+ E+LT K + L V
Sbjct: 447 NL----EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT-KLKTLTVMFV 501
Query: 1471 VTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQ 1530
+ ++ + ++ + +L +L ++ T+ EKL E+ KT+++ + S+
Sbjct: 502 DERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
Query: 1531 ERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERV 1590
+ ER D + +L+A ++ + L + D+ +
Sbjct: 562 K---------ER-------DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLK- 604
Query: 1591 SKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQ 1650
+K+ + ++ E+ K ++ D K + M T DE ++L +
Sbjct: 605 NKLNQDSGKSTTALHQENNKIKELSQEVERL-KLKLKDMKAIEDDLMKT-EDEYETLERR 662
Query: 1651 VSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVAC 1710
+ R + + LE + +A+ K +K+ H + +EE K L ++V
Sbjct: 663 YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEE-EAKSGHLSREVDA 721
Query: 1711 LEDELCE 1717
L++++ E
Sbjct: 722 LKEKIHE 728
Score = 48.0 bits (109), Expect = 3e-04
Identities = 79/433 (18%), Positives = 183/433 (42%), Gaps = 44/433 (10%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE--RVKVL 782
R+ + ELE++K K+ +++ I + + + + + K E+ RV L
Sbjct: 169 RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTL 228
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQKK------------PKTLIKSRSLDASDQQN 830
++E+ +++ + + +RL A+L+L ++K K + + +Q+
Sbjct: 229 KEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
Query: 831 VDLKRQLQV----IEQEASVLRAKTQSLEADNEKLQTENKKL-----QLLKNAKSLR-SD 880
L+++LQ Q+ + AK + ++ N +LQ + L +L + +SLR ++
Sbjct: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 348
Query: 881 KALDLNTKKTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFTEATKKETDTLKSKQX 938
+ L +K ++ E +A+++EL ++ + K E+ ++ E + L+ +
Sbjct: 349 EELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETL 408
Query: 939 XXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLEC 998
+ + Q+ + + + +TTK QL + +E L+
Sbjct: 409 QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-QLSQELESLKV 467
Query: 999 EIGEMYVV---MKNAGLSGKEMTAKTK------------LEKEIDEIRSKLSKNDSEFTN 1043
I E+ + ++ + KE K K + +++ + KL S+
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 1044 EKNRLQTEIAKL-KDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
E+N++ T KL ++ L+ DV Y ++ E +L N+ K E+ + +++N
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMY-SVTKERDDLKNKLKAEEEKGNDLLSRVN 586
Query: 1103 KLSADLKNATSLQ 1115
L L++ +++
Sbjct: 587 MLKNRLQSLEAIE 599
Score = 47.2 bits (107), Expect = 6e-04
Identities = 117/611 (19%), Positives = 242/611 (39%), Gaps = 47/611 (7%)
Query: 267 KEYQDQIEG----LKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
KEY ++ + L+QE + L+K ++ K + + + + T + T S L +
Sbjct: 183 KEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMV 242
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKL-LAAETLC 381
+ LT R + + LT +E ++L EA+ ++ EQ +L +T
Sbjct: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL---AEARVQEEEQKATRLEKELQTQT 299
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ + + + +L + +Q Q DE R L + + + + K+
Sbjct: 300 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGM-QRENRIKELEQEVARSTEVALRLQRELAE 498
K E + E E K++L++ G + + + E + ++L + + R T + + E+ +
Sbjct: 360 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK 419
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
+ + +L K+ + K + + + E + L LE L+ +++
Sbjct: 420 LSKRIM----ALEKL-EDAFNKSKQECYSLKCNLEKERMTTKQLSQELE---SLKVRIKE 471
Query: 559 AEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ--NKMIHAASTPSSKEKS 616
E + ++ T + + + E +T++ ++ + AAS+ E++
Sbjct: 472 LEAIESRLEKTE-FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 530
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
++ +K EET+ + ++ + V ++ + L +LK K
Sbjct: 531 KVTTVT-EKLIEETKRAL----------KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
Query: 677 SRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
N+L S+E + K D + L QE K++EL Q+
Sbjct: 580 DLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL---HQE----NNKIKELSQEV 632
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK-KLI 794
E LK ++K++ + + KT T RR N A+ K LE E+ K KL
Sbjct: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERR--YANERDKAQFLSKELEHVKMELAKYKLA 690
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI---EQEASVLRAKT 851
EK L +++ K+ SR +DA ++ + +I + + SVL+ KT
Sbjct: 691 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKT 750
Query: 852 QSLEADNEKLQ 862
+S ++ +
Sbjct: 751 KSTRKQEQRFR 761
Score = 44.4 bits (100), Expect = 0.004
Identities = 65/315 (20%), Positives = 126/315 (40%), Gaps = 13/315 (4%)
Query: 264 SNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ 323
+N KE ++ + V ++ R+EKE + + DT T S+ +LQ
Sbjct: 265 TNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ 324
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTE----AQTRQIEQLRAKLLAAET 379
QK+ L+ ++L + + L + E++ E E ++E+LR ++L E
Sbjct: 325 QKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEG 384
Query: 380 LCEEL--MDEN-EDMKKEL--RDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
EEL M+E D+ K L L ++ + L ++ + C L
Sbjct: 385 KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL 444
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQ 493
L+K QL QE + ++ E+ +++ E +KE ++ T + + +
Sbjct: 445 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
+ ++E K + Q E KV+ + + + D+++ + R
Sbjct: 505 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 564
Query: 554 EQLRN---AEEETAN 565
+ L+N AEEE N
Sbjct: 565 DDLKNKLKAEEEKGN 579
Score = 37.1 bits (82), Expect = 0.64
Identities = 49/224 (21%), Positives = 98/224 (43%), Gaps = 21/224 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK---- 321
+++ +D KQE L+ E+ E+ + L + L ++ K S + K
Sbjct: 427 LEKLEDAFNKSKQECYSLKCNLEK-ERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 485
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLC 381
L++ + +L T DE+K +++K+++ E +L+ S Q+EQ + T+
Sbjct: 486 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQ----LQVEQNKVT-----TVT 536
Query: 382 EELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKT 441
E+L++E + K D+ + R+D ++ + + + +L +L+
Sbjct: 537 EKLIEETKRALKSKTDVEEKMYSVTKE-RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL 595
Query: 442 ER-KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
E + D L+ + + K + Q N+IKEL QEV R
Sbjct: 596 EAIEKDFLKNKLNQDSGKSTTALH-----QENNKIKELSQEVER 634
>AF273043-1|AAG34903.1| 795|Homo sapiens CTCL tumor antigen se2-1
protein.
Length = 795
Score = 66.9 bits (156), Expect = 7e-10
Identities = 123/604 (20%), Positives = 253/604 (41%), Gaps = 37/604 (6%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETL 380
L + ++L E ++ K ++R+ ES+L E R EAQ + I++L+
Sbjct: 102 LSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLK 161
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
EE + EN+D+ KE +++ A++ E E+T + L+ ++K
Sbjct: 162 LEEGIQENKDLIKENNATRHLCNLLKETCAR-SAEKTKKYEYEREETRQVYMDLNNNIEK 220
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN 500
++L + +AE+ + + D + ++ +E ++E+ + L ++ E
Sbjct: 221 MITAFEEL-RVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKE 279
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAE 560
+K L + + KV++ +E +L+ S+E++ L ++L + +
Sbjct: 280 NKM----KDLTFLLEESRDKVNQ-------LEEKTKLQSENLKQSIEKQHHLTKELEDIK 328
Query: 561 EETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
D Q+ T I C + E + NK A S ++ ++
Sbjct: 329 VSLQRSVSTQKALEEDLQIATKTI--CQLTEEKETQMEESNKARAAHSFVVTEFETTVCS 386
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
L TE+ + + L I L+K ++ +EE + L K++ + + L
Sbjct: 387 LEELLRTEQQRLEKNEDQLKIL----TMELQKKSSELEEMTK--LTNNKEVELEELKKVL 440
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKL--LLELNEQEATVLRRKVEELEQDKEAL 738
K ++ N EK +E E +L LL+ E+E L ++ + ++
Sbjct: 441 -----GEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
K+VK+L +++ + K T+ L+ + +L +E + E+ ++ + ++
Sbjct: 496 SKEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQE-TSDMTLELKNQQEDINNNKK 553
Query: 799 DCERLHAELSLAQKKPKTLIKSRSL--DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
ER+ ++ Q+ L + Q+ ++K +L E+ + LR + ++
Sbjct: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
E+LQ ENK L+ A+S K L++ K +LE EL+ A K E+ Q E
Sbjct: 614 YIEELQQENKALKKKGTAES----KQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIE 669
Query: 917 EKKV 920
+KK+
Sbjct: 670 DKKI 673
Score = 62.1 bits (144), Expect = 2e-08
Identities = 85/406 (20%), Positives = 170/406 (41%), Gaps = 29/406 (7%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR-----SLTTNSNKLAEERV 779
++++ + E+ L Q+ E +K+ +T S + L + + K + E+
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
L E+++++ L + L +L +A K L + + + V
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
E E +V + + L + ++L+ +L++L +S + L+ TK T E EL+E
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSE-LEEMTKLTNNKEVELEE 435
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+ E E + + K +K+ E E + + Q Q
Sbjct: 436 LKKVLGEKETLLYENKQFEKIA-EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
K +KD + ++ K T+LT+ KL L+ ++L E +M + +KN ++
Sbjct: 495 YSKEVKDLKTELENEKL--KNTELTSHCNKLSLEN--KELTQETSDMTLELKN---QQED 547
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKYKA 1075
+ K E+ + + L + +++ NE ++ E+ + +D V KL+ ++ N K
Sbjct: 548 INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
Query: 1076 LENENS---NLSNQCKTL----TEEMKNR---EAQINKLSADLKNA 1111
+EN+N L + K L T E K E ++NKL +L++A
Sbjct: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESA 653
Score = 58.4 bits (135), Expect = 2e-07
Identities = 133/731 (18%), Positives = 289/731 (39%), Gaps = 56/731 (7%)
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L ++ E++++ K + + ++++ SK+ K A + L + K++ + + ++
Sbjct: 109 LYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQ 167
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ D +++ + C L + + +K K R + + Q +DL ++ +
Sbjct: 168 ENKDLIKENNATRHL-CNLLKETCARSAEKTKKYEYER--EETRQVYMDLNNNIEKMITA 224
Query: 844 ASVLRAKTQSLEADNE-KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA 902
LR + ++ + KL+ + +K+Q L+ K ++ K+ + L ++ E
Sbjct: 225 FEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK----KEINDKEKQVSLLLIQITEKEN 280
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
K+K+L + ++ + +K + E TK +++ LK +T K
Sbjct: 281 KMKDLTFLLEESR-DKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
+L++D Q I K T+ + +M E + +VV + T
Sbjct: 340 ALEEDLQ------IATKTICQLTEEKETQMEESNKARAAHSFVVTEFE-------TTVCS 386
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
LE+ + + +L KN+ + LQ + ++L+++ KL +K+V + K + E
Sbjct: 387 LEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT-KLTNNKEVELEELKKVLGEKET 445
Query: 1083 L---SNQCKTLTEEMKNREAQ-INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
L + Q + + EE+K E + I L A K L+ ++
Sbjct: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLT--AITTSEQYYSKEVKDLK 503
Query: 1139 XXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ N T++ NKL E + T++ D +L +++ +
Sbjct: 504 TELENEKLKN-TELTSHCNKLSLENKELTQETSDMTL--------------ELKNQQEDI 548
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
Q L T +L EL ++EL+ + + + K E +L+
Sbjct: 549 NNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV 608
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
ENK +E + ++ +K+ A + N Y+ + +E+ E+ Q
Sbjct: 609 ENKNKYIEE-LQQENKALKKKGTAESKQLN-VYEIKVNKLEL-ELESAKQKFGEITDTYQ 665
Query: 1319 DELNNAKIKLEKTEAESSAAKL---EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
E+ + KI E E AK+ E +L+ ++ K ++
Sbjct: 666 KEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDK--RCQHKIAEMVALMEKHKHQYDK 723
Query: 1376 KAKELDTDL---QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITE 1432
+E D++L +S+ ++ +R + + ++ N AEL ++K +L+I + + E
Sbjct: 724 IIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
Query: 1433 LKQEYEETVKK 1443
+E KK
Sbjct: 784 NTATLKEKKKK 794
Score = 56.4 bits (130), Expect = 1e-06
Identities = 118/696 (16%), Positives = 257/696 (36%), Gaps = 46/696 (6%)
Query: 840 IEQEASVLRAKTQSLEADN---EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
+ Q+ S L+ + +EA ++LQ N+K+ L K + ++ +K L T L N
Sbjct: 127 LRQKESKLQENRKIIEAQRKAIQELQFGNEKVSL-KLEEGIQENKDLIKENNATRHLCNL 185
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
LKE A+ E + E+ E + + + + + +
Sbjct: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245
Query: 957 XQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
++ L+ + +K + +K L L + + E ++ ++ +++ + +
Sbjct: 246 DYEKIQHLEQEYKKEINDK--EKQVSL-----LLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKAL 1076
+ KTKL+ E ++ + K T E ++ + + LE D + L
Sbjct: 299 LEEKTKLQSE--NLKQSIEKQH-HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQL 355
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXX 1136
E + E K R A ++ SL+ +
Sbjct: 356 TEEKET------QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILT 409
Query: 1137 XXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKD 1196
+++ TK+ +K L+E+ K +G+ K E+ T ++
Sbjct: 410 MELQKKSSELEEMTKLTNNKEVELEEL---KKVLGEKETLLYENKQFEKIAEELKGTEQE 466
Query: 1197 RV---TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK-TE--SKFITLEAE 1250
+ Q + + + S E+ K EL+ +K TE S L E
Sbjct: 467 LIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLE 526
Query: 1251 MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
++L + + L++ + + KQ E L+Q N + E ++R
Sbjct: 527 NKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETET-------QLRNELEYV 579
Query: 1311 XXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXS 1370
+DE+ K KL+K+E + + ++ + +L+
Sbjct: 580 REELKQKRDEV---KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 1371 SYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI 1430
+ +E K +L+ +L+S ++K + + K++++K L +++ + + K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQ 696
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEEL-------TGKYELLEEEHVVTKARLTVEKEQA 1483
E+ + + + ++ + K +Y+++ G Y+ E+E +A L +E
Sbjct: 697 KEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL 756
Query: 1484 QGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
+ ELL V+K+L E + L+ + +A +K
Sbjct: 757 KAELLSVKKQLEIEREEKEKLKREAKENTATLKEKK 792
Score = 53.2 bits (122), Expect = 9e-06
Identities = 92/458 (20%), Positives = 177/458 (38%), Gaps = 35/458 (7%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEADPAEM 710
K + E + LQ + +A+ + + N K+S++ E + +
Sbjct: 120 KVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNAT 179
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ L L ++ K ++ E ++E ++ +L + I + A S
Sbjct: 180 RHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEM 239
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK--TLIKSRSLDASDQ 828
KL E+ K+ E E +K++ +KE+ L +++ + K K T + S D +Q
Sbjct: 240 HFKLKEDYEKIQHLE-QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
K Q + ++Q T+ LE LQ + L+ + + L +
Sbjct: 299 LEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEE 358
Query: 889 KTTQLENELKEALAK---IKELEM-ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K TQ+E K A + E E +C E+ + + + +K D LK
Sbjct: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ--QRLEKNEDQLK--------IL 408
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L + K+ + K + +K T L Q +K+ E+L+ E+
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
GL + A+ K +++ + ++ ++ ++ E L+TE+ K N +L
Sbjct: 469 ------GL----LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS 518
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
NK L EN L+ + +T E+KN++ IN
Sbjct: 519 H----CNK---LSLENKELTQETSDMTLELKNQQEDIN 549
Score = 51.6 bits (118), Expect = 3e-05
Identities = 120/606 (19%), Positives = 242/606 (39%), Gaps = 58/606 (9%)
Query: 318 EVLKLQQKVNELTTHNEDLRDEKK--HLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
E L++Q + + L H + D +K HL Q+ ++ ++ E + S QI + K+
Sbjct: 226 EELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSL--LLIQITEKENKMK 283
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
L EE D+ ++++ + L + E ++ L++++ + L
Sbjct: 284 DLTFLLEESRDKVNQLEEKTK-LQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALE 342
Query: 436 FKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRE 495
L+ + QL +EK E ++ E + E E V S E LR +++
Sbjct: 343 EDLQIATKTICQLTEEK---ETQMEE--SNKARAAHSFVVTEFETTVC-SLEELLRTEQQ 396
Query: 496 LAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD---L 552
E N ++ E ++++ + + E+ ++L + + L +
Sbjct: 397 RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKI 456
Query: 553 REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN---SIQNKMIHAAST 609
E+L+ E+E Q D ++ I T + + S+ V + ++N+ +
Sbjct: 457 AEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTEL 516
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN--------NLRKTAARVEEDN 661
S K + + T + I N+ NL++T ++ +
Sbjct: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
E + +LK+ + + + N L + N N E + + +K ++
Sbjct: 577 EYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVK 780
V KV +LE + E+ K++ E+T + + N L E E+ K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKK----------ISEENLLEEVEKAK 686
Query: 781 VLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVI 840
V+ DE +++K++ ++ C+ AE+ +K K + ++ D + K +
Sbjct: 687 VIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQY-DKIIEERDSELGLYKSK---- 738
Query: 841 EQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEA 900
EQE S LRA SLE ++ N K +LL S++ K L++ ++ +L+ E KE
Sbjct: 739 EQEQSSLRA---SLE-----IELSNLKAELL----SVK--KQLEIEREEKEKLKREAKEN 784
Query: 901 LAKIKE 906
A +KE
Sbjct: 785 TATLKE 790
Score = 48.0 bits (109), Expect = 3e-04
Identities = 63/287 (21%), Positives = 128/287 (44%), Gaps = 19/287 (6%)
Query: 278 QEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLR 337
+EV L+ E EK K+ L + NK T +S++ EL ED+
Sbjct: 497 KEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQETSDMTL------ELKNQQEDIN 549
Query: 338 DEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAAETLCEELMDENEDMKKELR 396
+ KK + +++IE+ E TE Q R ++E +R +L + +D++E+ LR
Sbjct: 550 NNKKQEERMLKQIENLQE----TETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR 605
Query: 397 DLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHE 456
++ + E+ E +L+++ K V K+ K E + + +Q+ E
Sbjct: 606 ----KQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 457 KKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP 516
+ + + EN ++E+E+ + E A++LQ+E+ + +LM+ +
Sbjct: 662 DTYQKEIEDKK-ISEENLLEEVEKAKVIADE-AVKLQKEIDKRCQHKIAEMVALMEKHKH 719
Query: 517 ETVKVSRSSLTRGGSQEDPAQLLRDLQDSLERE-ADLREQLRNAEEE 562
+ K+ + G + Q L+ SLE E ++L+ +L + +++
Sbjct: 720 QYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQ 766
Score = 34.7 bits (76), Expect = 3.4
Identities = 51/309 (16%), Positives = 120/309 (38%), Gaps = 16/309 (5%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
E++E + ++ + + +L+ EN + + I+ LE ++ N
Sbjct: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
Query: 1289 DKYDEAT-SPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKS 1347
DK + + +++ E +D++N + EKT+ +S K + +
Sbjct: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE---EKTKLQSENLKQSIEKQHH 319
Query: 1348 DLAKLENXXXXXXXXXXXXXXXSSYWENKAK---ELDTDLQSERKKLDRMRIAHDKDVKN 1404
+LE+ + K +L + +++ ++ ++ R AH V
Sbjct: 320 LTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTE 379
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+ + +L+ L+ +Q ++ L E ++ +LE L + EL ++
Sbjct: 380 FETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKV 439
Query: 1465 LEEEHVVTKARLTVEK--EQAQG---ELLHVQKELSTALGEIKTLQEKLGTESAAWNTE- 1518
L E+ + EK E+ +G EL+ + + + +++ + T ++ E
Sbjct: 440 LGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEV 499
Query: 1519 ---KTEMQN 1524
KTE++N
Sbjct: 500 KDLKTELEN 508
>AB208841-1|BAD92078.1| 1585|Homo sapiens Nuclear mitotic apparatus
protein 1 variant protein.
Length = 1585
Score = 66.9 bits (156), Expect = 7e-10
Identities = 174/899 (19%), Positives = 361/899 (40%), Gaps = 84/899 (9%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
+ Q+Q++ LK+ + + + E ++ +D L + I K T E K ++K
Sbjct: 183 QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL-KAETRSLVEQHKRERK-- 239
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
EL E+ R +K L +++++ + TE R++ + A AE+ CE+L+ E
Sbjct: 240 EL----EEERAGRKGLEARLQQLGEAHQA--ETEVLRRELAEAMAAQHTAESECEQLVKE 293
Query: 388 NEDMKKELRDLXXXXXXMQDNFRED---QADEYSSLRRELEQT-IKNCRVLSFKLKKTER 443
++ D F+E +E R+EL++ K + S + R
Sbjct: 294 VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR 353
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQR-ENRIKELEQEVARSTEVALRLQRELAEANSK 502
+ ++L + A + L ++ Q+ + + L++++A +++ RL+ + +A +
Sbjct: 354 QQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQ 413
Query: 503 FTGSNPSLMKVP------QPETVKVSRS---SLTRGGSQ------EDPAQLLRDLQDSL- 546
++ L+K P QPE ++ + T+ Q E L L+ +L
Sbjct: 414 QETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALM 473
Query: 547 EREADLREQLRNAEEETANCKQ----VNPPTFLDKQVMTDNIVTCD--IHESETVTNSIQ 600
E + +E+ E E A Q L+K + + ++E ++Q
Sbjct: 474 ESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQ 533
Query: 601 NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED 660
+ HA + K++ L+ + E Q +L L L++ A+ E++
Sbjct: 534 EALAHALTEKEGKDQE----LAKLRGLEAAQIK-ELEEL----RQTVKQLKEQLAKKEKE 584
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLE---LN 717
+ S + A R+ P A + + +K+ ++AD E L E
Sbjct: 585 HASGSGAQSEAA--GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA 642
Query: 718 EQEATV------LRRKVEELEQDKEALKKQVKELTSKISSVTKTS-AGSNTTARRSLTTN 770
E+++ + L K +EL + AL +EL + + V S A A+ +
Sbjct: 643 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 702
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLH----AELSLAQKKPKTLIKSRSLDAS 826
+ + LE+E+ + ++++EKE + + L AE +QK + L ++ AS
Sbjct: 703 EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETAS 762
Query: 827 D-----QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLK--NAKSLR 878
+ +++ L+ ++Q + +EA R +++L + ++L Q LK K +
Sbjct: 763 NSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQ 822
Query: 879 SDKALDLNTKKTTQLENELKEAL-AKIKELEMICQDEKSEKKVRFTEATKKETDTL-KSK 936
++AL T QLE+ +AL +++ + +CQ ++E+ A K+ + L +SK
Sbjct: 823 KEQAL-----STLQLEHTSTQALVSELLPAKHLCQQLQAEQ----AAAEKRHREELEQSK 873
Query: 937 QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDL 996
Q K + Q+ ++ + +L + K L
Sbjct: 874 QAAGGLRAELLRAQRELGELIPLRQKVAE---QERTAQQLRAEKASYAEQLSMLKKAHGL 930
Query: 997 ECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK 1056
E N G E+ EK + E+ + + ++ + Q+ +L+
Sbjct: 931 LAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELE 990
Query: 1057 DVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQ 1115
+ AK EG K + + + E L+ Q + L++++ + + Q +K+ A Q
Sbjct: 991 VMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLADSD-QASKVQQQKLKAVQAQ 1048
Score = 66.9 bits (156), Expect = 7e-10
Identities = 128/647 (19%), Positives = 264/647 (40%), Gaps = 53/647 (8%)
Query: 272 QIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEV-LKLQQKVNELT 330
++E L+Q V L+++ + EKE A+ A GR+ KL+ E++
Sbjct: 563 ELEELRQTVKQLKEQLAKKEKEH--------ASGSGAQSEAAGRTEPTGPKLEALRAEVS 614
Query: 331 THNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENED 390
+ + +++ R +E+E +R ++ +E L+ +L E +EL
Sbjct: 615 KLEQQCQKQQEQADSLERSLEAERASRAERDSA---LETLQGQL---EEKAQELGHSQSA 668
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
+ R+L +QD+ + + + R E KN + S + + + LE+
Sbjct: 669 LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEK 728
Query: 451 EKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
E E K L + + E R++ L+ E A ++ A AE +S SL
Sbjct: 729 EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA-------AERSSALREEVQSL 781
Query: 511 MKVPQPETVKVS--RSSLTRGGSQ-EDPAQLLRDLQDSLEREADLREQLRNAEEET-ANC 566
+ + + V R LT + E+ Q L+ Q+ ++ L+ T A
Sbjct: 782 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 841
Query: 567 KQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKT 626
++ P L +Q+ + H E + + A + +E + PL K
Sbjct: 842 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLR-QKV 900
Query: 627 TEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNE------SLLLQLKKMATKARSRKL 680
E+ + L + L+K + E+N +L Q ++ K
Sbjct: 901 AEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKY 960
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKK 740
A + ET ++E ++ E++++ E + + + +++++ L
Sbjct: 961 VQELAAVRADAETRLAEVQREA-QSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTA 1019
Query: 741 QVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDC 800
QV+EL+ K++ + S + +++ + L+ +++E++ +L +KE+
Sbjct: 1020 QVEELSKKLADSDQASKVQQQKLKAVQAQGGE--SQQEAQRLQAQLNELQAQLSQKEQAA 1077
Query: 801 ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK 860
E H +L + +K KT DA QQN +L+ QL+ +EQ L+ + + L A+ E+
Sbjct: 1078 E--HYKLQM--EKAKT-----HYDAKKQQNQELQEQLRSLEQ----LQKENKELRAEAER 1124
Query: 861 LQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
L E ++ L K+ +++ T + LE ++ A ++++L
Sbjct: 1125 LGHELQQAGL----KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1167
Score = 62.1 bits (144), Expect = 2e-08
Identities = 139/691 (20%), Positives = 285/691 (41%), Gaps = 59/691 (8%)
Query: 271 DQIEGLKQEVDILRKRCERVEKEKS---DILLRRL--AN--IDTANKYTTGRSSEVLKLQ 323
++ E +E D K+ E +EKEK+ +IL ++L AN D+A T E +L
Sbjct: 74 EEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 133
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESEL--ETRPSTEAQ--TRQIEQLRAKLLAAET 379
+KV EL E R E+ ++ E+E +L E + +TE + ++ +QL+ +L A +
Sbjct: 134 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKE 193
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ---ADEYSSLRRELEQTIKNCRVLSF 436
+ E+ K+ D + + +++ R+ELE+ + L
Sbjct: 194 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 253
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
+L++ +A Q E E E L E + E+ ++L +EVA E Q+E
Sbjct: 254 RLQQL-GEAHQAETEVLRRE--LAEAMAAQH--TAESECEQLVKEVAAWRERYEDSQQEE 308
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRS-SLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
A+ + F +L + + ++ + G Q+ R + E A+L
Sbjct: 309 AQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARA 368
Query: 556 LRNAEEETANCKQV--NPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSK 613
L+ +E+ +++ + T +K T ++ ET+ + +S+
Sbjct: 369 LQQVQEKEVRAQKLADDLSTLQEKMAATSK----EVARLETLVRKAGEQ-----QETASR 419
Query: 614 EKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMAT 673
E P + D+ E + + S A + + A ++ + E L L +
Sbjct: 420 ELVKEPARAGDRQPEWLEEQQGRQFCS--TQAALQAMEREAEQMGNELERLRAALMESQG 477
Query: 674 KARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLE--LNEQE---ATV---LR 725
+ + + +L+ E + ++A AE+++ L+ LNEQ AT+ L
Sbjct: 478 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 537
Query: 726 RKVEELE-QDKEALK------KQVKELTSKISSVTKTSAG-SNTTARRSLTTNSNKLAEE 777
+ E E +D+E K Q+KEL +V + + + + + A
Sbjct: 538 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 597
Query: 778 RVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV--DLKR 835
R + +++ +R ++ + E+ C++ + ++ + SR+ S + + L+
Sbjct: 598 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 657
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENK-----KLQLLKNAKSL-RSDKALDLNTKK 889
+ Q + S L + + L A K+Q +K K Q+ + + R + + ++
Sbjct: 658 KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE 717
Query: 890 TTQLENELKEALAKIKELE--MICQDEKSEK 918
+ L ++ E + KEL+ ++ + EKS+K
Sbjct: 718 VSILNRQVLEKEGESKELKRLVMAESEKSQK 748
Score = 50.4 bits (115), Expect = 6e-05
Identities = 88/426 (20%), Positives = 178/426 (41%), Gaps = 22/426 (5%)
Query: 700 KETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGS 759
K+ + A++ L+ EQ + LR +VE+L + ++Q+KE+ K + + A
Sbjct: 9 KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ 68
Query: 760 NTTA--RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDC---ERLHAELSLAQKKP 814
TA R + A ++++ LE E + ++++++ R A+ S+ Q +
Sbjct: 69 LATAAEEREASLRERDAALKQLEALEKE-KAAKLEILQQQLQVANEARDSAQTSVTQAQR 127
Query: 815 KTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA 874
+ SR ++ Q V+ RQ Q E +A V + Q L ++ +K TE +++ K+
Sbjct: 128 EKAELSRKVEEL-QACVETARQEQ-HEAQAQVAELELQ-LRSEQQK-ATEKERVAQEKD- 182
Query: 875 KSLRSDKALDLNTKKTT-QLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTL 933
+ +AL + K T LE E + A ++E + + K+E + E K+E L
Sbjct: 183 QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETR-SLVEQHKRERKEL 241
Query: 934 KSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMV 993
+ ++ L+ +A + + + ++
Sbjct: 242 EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERY 301
Query: 994 EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIA 1053
ED + E + + + ++ KE K + +E+ E + K++ +S + +R Q E+A
Sbjct: 302 EDSQQEEAQYGAMFQEQLMTLKEECEKAR--QELQEAKEKVAGIESHSELQISRQQNELA 359
Query: 1054 KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
+L +A L K E L++ TL E+M ++ +L ++ A
Sbjct: 360 EL---HANLARALQQVQEK----EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE 412
Query: 1114 LQTTMS 1119
Q T S
Sbjct: 413 QQETAS 418
Score = 50.0 bits (114), Expect = 8e-05
Identities = 125/632 (19%), Positives = 243/632 (38%), Gaps = 51/632 (8%)
Query: 1186 RIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI 1245
++++QL K+ + +A +R EL +E L + K E K
Sbjct: 183 QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH-KRERK-- 239
Query: 1246 TLEAEMRDLKADYENKITSL-ESTIAAKDVHIKQLEDAL--RQTTNDKYDEATSPVEMVE 1302
LE E K E ++ L E+ A +V ++L +A+ + T + ++ V
Sbjct: 240 ELEEERAGRKG-LEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR 298
Query: 1303 MRXXXXXXXXXXXXX--QDELNNAKIKLEKTEAESSAAKLEMAQLKS----DLAKLENXX 1356
R Q++L K + EK E AK ++A ++S +++ +N
Sbjct: 299 ERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNEL 358
Query: 1357 XXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL--DRMRIAHDKDVKNKDAELATLKG 1414
E +A++L DL + ++K+ +A + + K E
Sbjct: 359 AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 418
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKA 1474
+ +++++ + AG ++ L+++ + +L + E E++ + E L + ++
Sbjct: 419 R-ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQG 477
Query: 1475 RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLC 1534
+ E+ Q + E+ + +E A ++ + E + A+LQE L
Sbjct: 478 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 537
Query: 1535 GG-----GWEVERARLNA-------RLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXX 1582
G + E A+L L++ + ++ ++ E H
Sbjct: 538 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 597
Query: 1583 XXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQS---EKARKAEITDTKTRYEGQMNT 1639
+ R +E+S E+A +AE +GQ+
Sbjct: 598 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 657
Query: 1640 MRDELKSLHNQVSRFRRE----RDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEE 1695
EL + ++ +RE R + +A + A++ G + A +NS+ S+ EE
Sbjct: 658 KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE-RKNSLISSLEE 716
Query: 1696 EYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERL 1755
E V++L +QV LE E ES+ L + E SEKS +++ RL + E
Sbjct: 717 E----VSILNRQV--LEKE-GESKELKRLVMAE--SEKSQ------KLEERLRLLQAETA 761
Query: 1756 LSSGRARVAGLATRMELAWHKERDEQQRLLQE 1787
+S RA A R E+ +E E+QR+ E
Sbjct: 762 SNSARAAERSSALREEVQSLREEAEKQRVASE 793
Score = 44.0 bits (99), Expect = 0.006
Identities = 73/396 (18%), Positives = 153/396 (38%), Gaps = 28/396 (7%)
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+D ELA LK + K + ++ + Q V++L SL ++ + +E+ K E
Sbjct: 1 QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 60
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
++H A E+E + E K+L E E L + N + Q
Sbjct: 61 TRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 120
Query: 1525 SIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
S+ Q E+A L+ ++++ + + A + +
Sbjct: 121 SVTQAQR---------EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 171
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
+ ERV++ + +E+ EK R A+ + + R ++ ++ E
Sbjct: 172 TEKERVAQEKDQLQEQLQALKESLKVTKGSLEE-EKRRAADALEEQQRC---ISELKAET 227
Query: 1645 KSLHNQVSRFRRERDNY---KQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
+SL Q R R+E + ++ LEA + + E + + + + ++
Sbjct: 228 RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 287
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRA 1761
L ++VA + +S+ E + + +L ++ + +E L +
Sbjct: 288 EQLVKEVAAWRERYEDSQ-------QEEAQYGAMFQEQLMTLKEECEKARQE--LQEAKE 338
Query: 1762 RVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+VAG+ + EL ++++E L + + LAR L+Q
Sbjct: 339 KVAGIESHSELQISRQQNE---LAELHANLARALQQ 371
Score = 42.3 bits (95), Expect = 0.017
Identities = 188/1140 (16%), Positives = 417/1140 (36%), Gaps = 73/1140 (6%)
Query: 470 QRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQP-ETVKVSRSSLTR 528
Q + + +L Q + + + + L+ ++ + +S L +V + E + +
Sbjct: 11 QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLA 70
Query: 529 GGSQEDPAQLL-RDLQ----DSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
++E A L RD ++LE+E + ++ + + AN + + T + +
Sbjct: 71 TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKA 130
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
++ + E + + + + A + + E K TE+ + + L
Sbjct: 131 ELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ--KATEKERVAQEKDQLQEQL 188
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD 703
+L+ T +EE+ L++ K + E +E+
Sbjct: 189 QALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR 248
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
+ A ++ L E ++ E VLRR++ E + + + ++L ++++ + S
Sbjct: 249 KGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEE 308
Query: 764 RRSLTTNSNKLA--EERVKVLEDEIDEVRKKL--IE---------KERDCERLHAELSLA 810
+ +L +E + E+ E ++K+ IE ++ + LHA L+ A
Sbjct: 309 AQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARA 368
Query: 811 -QKKPKTLIKSRSL--DASDQQNVDLKRQLQVIEQEASVLRA----KTQSLEADNEKLQT 863
Q+ + ++++ L D S Q +V E V +A +T S E E +
Sbjct: 369 LQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA 428
Query: 864 ENKKLQLLKNAKSLR---SDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKK- 919
+++ + L+ + + + AL ++ Q+ NEL+ A + E + Q+E+ +++
Sbjct: 429 GDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQER 488
Query: 920 --VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDA--QKSFKPR 975
R T+ + L ++ ATL+ A +K K +
Sbjct: 489 EVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQ 548
Query: 976 IPKKPTDLTTKLQLKKMVEDLECEIGEMYVVM-----KNAGLSGKEMTAKTKLE---KEI 1027
K L Q+K++ E+L + ++ + ++A SG + A + E ++
Sbjct: 549 ELAKLRGLEA-AQIKEL-EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 606
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC 1087
+ +R+++SK + + ++ + + L+ A LE + L +
Sbjct: 607 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ 666
Query: 1088 KTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD 1147
L + A K+ K + ++ QV
Sbjct: 667 SALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 726
Query: 1148 NYTKIDQDKNKLLKEVGDKTKKIGD-XXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXX 1206
++ +L+ +K++K+ + R ++ S ++ V
Sbjct: 727 EKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEV---QSLRE 783
Query: 1207 XXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLE 1266
Q V N + L+ + +EL + KF E + L+ ++ + +
Sbjct: 784 EAEKQRVASENLRQELTSQ-AERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVS 842
Query: 1267 STIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNN-AK 1325
+ AK H+ Q A + ++ E E+ + + Q EL
Sbjct: 843 ELLPAK--HLCQQLQAEQAAAEKRHRE-----ELEQSKQAAGGLRAELLRAQRELGELIP 895
Query: 1326 IKLEKTEAESSAAKL--EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK-ELDT 1382
++ + E E +A +L E A L+ L+ ++ + ELD
Sbjct: 896 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ 955
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVK 1442
+ ++L +R + + E + +L+++ ++ E +Q ++E +
Sbjct: 956 AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQ 1015
Query: 1443 KLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIK 1502
KL A+ EEL+ K ++ V + +L + QAQG Q+E ++
Sbjct: 1016 KL-------TAQVEELSKKLADSDQASKVQQQKL--KAVQAQGG--ESQQEAQRLQAQLN 1064
Query: 1503 TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
LQ +L + A K +M+ + + E+ R +L + +ELRA +R
Sbjct: 1065 ELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAER 1124
Score = 35.1 bits (77), Expect = 2.6
Identities = 77/397 (19%), Positives = 147/397 (37%), Gaps = 32/397 (8%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E RK L+ +S E+E SI + +SKE ++ + E+S ++ L+Q +
Sbjct: 703 EAERKNSLI---SSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAE 759
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
+ NS + + ++ E L QE+ +++
Sbjct: 760 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK 819
Query: 287 CERVEKEKSDILLRRLANIDTANKYTTGRS-SEVLKLQQKVNELTTHNEDLRDEKKHLTQ 345
+ E+ S + L + ++ + + L+ +Q E H E+L K Q
Sbjct: 820 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE-KRHREELEQSK----Q 874
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXM 405
+ +EL + + ++ LR K+ E ++L E ++L L +
Sbjct: 875 AAGGLRAEL---LRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLL 931
Query: 406 QDNFREDQADEYSSLRRE-LEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG 464
+ R E ++L R+ LE + R E+ +L +A+ E +L E+
Sbjct: 932 AEENR--GLGERANLGRQFLEVELDQAR---------EKYVQELAAVRADAETRLAEVQR 980
Query: 465 GPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK--VPQPETVKVS 522
RE + + E A+ L ++ E K T L K + KV
Sbjct: 981 EAQSTARELEVMTAKYEGAKVK--VLEERQRFQEERQKLTAQVEELSKKLADSDQASKVQ 1038
Query: 523 RSSL----TRGGSQEDPAQLLRDLQDSLEREADLREQ 555
+ L +GG + AQ L+ + L+ + +EQ
Sbjct: 1039 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1075
>BC131805-1|AAI31806.1| 913|Homo sapiens CCDC46 protein protein.
Length = 913
Score = 66.5 bits (155), Expect = 9e-10
Identities = 120/621 (19%), Positives = 251/621 (40%), Gaps = 40/621 (6%)
Query: 329 LTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDEN 388
L + N L + K + K E + +L+ + + Q + +E+ ++ +TL E
Sbjct: 208 LNSWNLGLDMKTKMMEAKFHEEKLKLQQKHDADVQ-KILERKNNEIEELKTLYRSKQHET 266
Query: 389 EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQL 448
E+ ++L RE + D+ + L++ EQ+ ++ + KK ++
Sbjct: 267 EETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLN--NDWEKKLHNAVAEM 324
Query: 449 EQEKAEHEKKLLEIVGGPDGMQREN-RIKELEQEVARSTEVALRLQRELAEANSKFTGSN 507
EQEK + +K+ E + + ++ N R+ ++E E T+ + +EL + TG
Sbjct: 325 EQEKFDLQKQHTENI--QELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTG-- 380
Query: 508 PSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ---DSLEREADLREQLRNAEEETA 564
+ S+L R ++ A+L R Q L+ R L ++
Sbjct: 381 ------------EAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLV 428
Query: 565 NCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSID 624
N + N K N++ + S + +S+ ++ + +
Sbjct: 429 NDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQ 488
Query: 625 KTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTP 684
+E +F + +L A++L+ + +ED + + + ++ A K + +L+
Sbjct: 489 LRDQENKFQMEKSHLKHIYEEKAHDLQSELDKGKEDTQKKIHKFEE-ALKEKEEQLTRVT 547
Query: 685 PANKLSIETANDNDEKETDEADPAEMKLLLELNEQ----EATVLRRKVEELEQDKEALKK 740
+L + A+ E+ + + K+ E+ EQ EA + R K +Q KE L
Sbjct: 548 EVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLW- 606
Query: 741 QVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDC 800
Q++++ + + + L N + V+ E EI+ + K+L +
Sbjct: 607 QLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEH 666
Query: 801 ERLHAELSLAQKKPKTLIKSRSLDASDQQ-NVDLKRQLQVIE----QEASVLRAKTQSLE 855
E E + ++++ ++ NV+ +R+ Q++E +E RA T+ E
Sbjct: 667 ENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRA-TREHE 725
Query: 856 ADNEKLQTENKKLQL-LKNAKSLRSDKALDLNTKKTTQLENELKEALAK----IKELEMI 910
KL+ E++K+++ LK + ++ L+ K Q+E E + LAK I EL+
Sbjct: 726 IVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTT 785
Query: 911 CQDEKSEKKVRFTEATKKETD 931
K E + A ++ D
Sbjct: 786 ISSLKEENSQQQLAAERRLQD 806
Score = 54.4 bits (125), Expect = 4e-06
Identities = 104/452 (23%), Positives = 190/452 (42%), Gaps = 49/452 (10%)
Query: 700 KETDEADPAEMKLLLE-----LNEQEATVLRRKVEELEQDKEALKKQVKELTSKI---SS 751
+ET E AE+K + E LN L V E+EQ+K L+KQ E ++ ++
Sbjct: 288 RETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTN 347
Query: 752 VTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDE---VRKKLIEKERDCERLH---- 804
V S A+ T + K E RV+ L E + R+KLI+++ + ER +
Sbjct: 348 VRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITC 407
Query: 805 AELSLAQKKPKTLIKSRSLDASD-QQNVDLKR-----QLQVIEQEASVLRAKTQSLEADN 858
+EL + + TL K + +D +QN+ L + + +++QE ++ +K S+ +
Sbjct: 408 SELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEEL 467
Query: 859 EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN--ELKEALAKIKELEMICQDEKS 916
E+ + K Q L+ ++ R + D K + + + E A + E+ E +
Sbjct: 468 EQNVCQLK--QQLQESELQRKQQLRDQENKFQMEKSHLKHIYEEKAHDLQSELDKGKEDT 525
Query: 917 EKKV-RFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR 975
+KK+ +F EA K++ + L ++ Q L S K A+ K +
Sbjct: 526 QKKIHKFEEALKEKEEQL-TRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAE--MKEQ 582
Query: 976 IPKKPTDLTTKLQLKK--------MVEDLECEIGEMYVVMKNAGLSGK-EMTAKTKLEKE 1026
+ K DLT L++ +ED+ + V +K K + + EK+
Sbjct: 583 MEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKD 642
Query: 1027 --IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK-ALENENSNL 1083
+ + ++ + + + +I + K +A++ D + +K + L N NS
Sbjct: 643 SLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQR 702
Query: 1084 SNQ---CKTLTEEMKNR-----EAQINKLSAD 1107
Q L EE K R E +NKL A+
Sbjct: 703 KQQLVELGLLREEEKQRATREHEIVVNKLKAE 734
Score = 46.4 bits (105), Expect = 0.001
Identities = 93/467 (19%), Positives = 204/467 (43%), Gaps = 32/467 (6%)
Query: 316 SSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPS--TEAQTRQIEQLRAK 373
SS + +L+Q V +L + L++ + Q++R+ E++ + S + L+++
Sbjct: 461 SSMIEELEQNVCQL---KQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEEKAHDLQSE 517
Query: 374 LLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADE-YSSLRRELEQTIKNCR 432
L + ++ + + E+ KE + +Q + QAD +R++E + + +
Sbjct: 518 LDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQ-RLQAQQADAALEEFKRQVE--LNSEK 574
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRL 492
V + ++ E+ L + K+ EK+ E + + +++ + +E ++ E L
Sbjct: 575 VYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLL 634
Query: 493 QRELAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
Q+ AE +S + + Q + + + + D AQ++ D++ + +
Sbjct: 635 QQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRD-AQVIADMEAQVHK--- 690
Query: 552 LREQLRNAEEETAN-CKQVNPPTFLDKQVMT-DNIVTCDIHESETVTNSIQNKMIHAAST 609
LRE+L N + ++ +KQ T ++ + + ++E+ I+ K HAA T
Sbjct: 691 LREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAET 750
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
+ EK++S I+K E TQ L+ + + A L+ T + ++E+N L +
Sbjct: 751 EMTLEKANSKLKQIEK--EYTQ------KLAKSSQIIA-ELQTTISSLKEENSQQQLAAE 801
Query: 670 KMATKARSR---KLSPTPPANKLSIETANDNDEKETDEADPAEMKLL-LELNEQE-ATVL 724
+ R + + N +I+ D E +++ AE KL EL QE T +
Sbjct: 802 RRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYI 861
Query: 725 RRKVEELEQD--KEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
R++ E + +L++++++ S + S + + LTT
Sbjct: 862 RQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTT 908
Score = 37.1 bits (82), Expect = 0.64
Identities = 59/291 (20%), Positives = 125/291 (42%), Gaps = 14/291 (4%)
Query: 274 EGLKQEVDILRKRCE--RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTT 331
E LK++ + L + E R++ +++D L N +E+ + +KV T
Sbjct: 534 EALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKV--YAEMKEQMEKVEADLT 591
Query: 332 HNEDLRDEK-KHLTQKIREIESELETRP---STEAQTRQIEQLRAKLLAAETLCEELMDE 387
++ LR+++ K ++ +I E + E + + L+ ++L + E
Sbjct: 592 RSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHERE 651
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
E+++K+LR F++ A + + ++ + + ++ + K+ +
Sbjct: 652 IENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL 711
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAEANSKFTGS 506
L +E+ + + EIV + E EL++ A TE+ L + +L + ++T
Sbjct: 712 LREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYT-- 769
Query: 507 NPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
L K Q ++ + SSL SQ+ A R LQD ++ D ++QL
Sbjct: 770 -QKLAKSSQIIAELQTTISSLKEENSQQQLA-AERRLQDVRQKFEDEKKQL 818
Score = 35.9 bits (79), Expect = 1.5
Identities = 56/295 (18%), Positives = 112/295 (37%), Gaps = 30/295 (10%)
Query: 1211 QAVVLANTHRRLSIELTSEKDELQARFIKTESKFI-TLEAEMRDLKADYENKITSLES-- 1267
Q V L H + L + + + ++ + I LE ++R ++EN+I +
Sbjct: 618 QIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRD 677
Query: 1268 --TIAAKDVHIKQLEDALRQTTNDKYDEATSP--VEMVEMRXXXXXXXXXXXXXQDELNN 1323
IA + + +L + L + + + + E + + E
Sbjct: 678 AQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEK 737
Query: 1324 AKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD 1383
KI+L+KT A + LE A K + E ++ K +
Sbjct: 738 MKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQ 797
Query: 1384 LQSERKKLD-RMRIAHDKD--VKNKDAELATLKGKL-----------KILEQNSGAGAKR 1429
L +ER+ D R + +K +++ D + L+ +L K L+ ++
Sbjct: 798 LAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQ 857
Query: 1430 ITELKQEYEETVK---------KLEHSLALEKAEYEELTGKYELLEEEHVVTKAR 1475
IT ++QEYE +K +LE +++ K++ L + +L+EE + R
Sbjct: 858 ITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGR 912
>AK126045-1|BAC86410.1| 978|Homo sapiens galactosaminyltransferase 9
protein.
Length = 978
Score = 66.5 bits (155), Expect = 9e-10
Identities = 157/910 (17%), Positives = 361/910 (39%), Gaps = 57/910 (6%)
Query: 638 YLSIFNHMAANNLRKTAARVEEDNESLLLQLK-KMATK-ARSRKLSPTPPANKLSIETAN 695
YLS + + +N E N+ ++ +L+ K+A K A +KL AN+LS
Sbjct: 93 YLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLIT 152
Query: 696 DNDEKETDEADPAEMKLLLELNEQEATVLRRKVE-----ELEQDKEALKKQVKELTSKIS 750
ND +E+ + E + + Q A ++ + + + E++++ L ++EL +K+
Sbjct: 153 CNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLI 212
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ + S+ + T+ +L +E L ++ K E + C +L L+L
Sbjct: 213 QI--EAENSDLKVNMAHRTSQFQLIQEE---LLEKASNSSKLESEMTKKCSQL---LTLE 264
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL---QTENKK 867
++ + ++ S+ A +N +L+++L ++ +R+ ++ ++EK+ + KK
Sbjct: 265 KQLEEKIVAYSSIAA---KNAELEQELM---EKNEKIRSLETNINTEHEKICLAFEKAKK 318
Query: 868 LQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEK--------SEKK 919
+ L ++ + + + L+ +K Q E ++ ++ +++ ++IC+ +E K
Sbjct: 319 IHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ-DIICKQHHLESLDRLLTESK 377
Query: 920 VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQAT----LKSLKDDAQKSFKPR 975
+ K+ + LK+ Q + L L+ + +K F+ +
Sbjct: 378 GEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEK-FEKQ 436
Query: 976 IPKKPTDL-TTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK-EIDEIRSK 1033
+ KK ++ + +LK L+ E E V++++ ++M + + E+++ ++K
Sbjct: 437 LKKKSEEVYCLQKELKIKNHSLQ-ETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK 495
Query: 1034 LSKNDSEFTNE-KNRLQTEIAKLKDVNAKLEG---DKDVFANKYKALENENSNLSNQCKT 1089
L K S+ E + + ++ KL+ + K E + D+ K L + +
Sbjct: 496 LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ 555
Query: 1090 LTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNY 1149
EE+ E +I L D +N ++ + D M Q
Sbjct: 556 YKEELSKMEKEIMHLKRDGEN-KAMHFSQLD-MILDQTKTELEKKTNAVKELEKLQHSTE 613
Query: 1150 TKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXX 1209
T++ + K + G+ ++K + +++ T
Sbjct: 614 TELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELR 673
Query: 1210 XQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTI 1269
+ + + + L +E+ E + ++ L+ +R+ + + E KI LE T+
Sbjct: 674 ECKMEIEDEKQEL-LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTL 732
Query: 1270 AAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK-L 1328
++ +K+ + ++ NDK A + E + E ++K +
Sbjct: 733 EKSELELKECNKQI-ESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEM 791
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
E E + DL + + + + +A+ L SE
Sbjct: 792 ESVMKEQEQYIATQCKEAIDLGQKLRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 851
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
+ D +++ +KD LA G K+ E + A+ E+K+ E V+ L+ +
Sbjct: 852 E--DMKQLSKEKDAHGN--HLAEELGASKVREAH--LEARMQAEIKKLSAE-VESLKEAY 904
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+E ++E K+++ + + +L + E+A+ EL Q +S +++ E +
Sbjct: 905 HMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVI 964
Query: 1509 GTESAAWNTE 1518
+ A T+
Sbjct: 965 EAANEALLTK 974
Score = 62.1 bits (144), Expect = 2e-08
Identities = 119/668 (17%), Positives = 293/668 (43%), Gaps = 58/668 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
K+Y+ + + L ++ LR + ++E E SD+ ++ A+ R+S+ +Q+++
Sbjct: 191 KQYEKERQRLVTGIEELRTKLIQIEAENSDL------KVNMAH-----RTSQFQLIQEEL 239
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
E +++ L E ++ +E +LE + + AK E +ELM+
Sbjct: 240 LEKASNSSKLESEMTKKCSQLLTLEKQLEEK------IVAYSSIAAKNAELE---QELME 290
Query: 387 ENEDMKKELRDLXXXXXXM---QDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+NE ++ ++ + + ++ +++ + +++E+ + K+ E+
Sbjct: 291 KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEK 350
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKF 503
L+Q+ + L + D + E++ E+++E + E LQ +++E K
Sbjct: 351 TMSMLQQDIICKQHHLESL----DRLLTESK-GEMKKENMKKDEALKALQNQVSEETIKV 405
Query: 504 TGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEET 563
+ S +++ + E V + G ++ QL + ++ + +L+ + ++ +ET
Sbjct: 406 RQLD-SALEICKEEL--VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK-NHSLQET 461
Query: 564 ANCKQVNPPTFLDKQVM--TDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
+ + T +Q M + I ++ +++T +K+ +E S
Sbjct: 462 SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKL--EQELQKQRESSAEKLR 519
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
+++ E DL + L TA +V+ + + +L KM + K
Sbjct: 520 KMEEKCESAAHEADLKRQKVI------ELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 573
Query: 682 PTPPANKLS-IETANDNDEKETDEADPA--EMKLLLELNEQEATVLRRKVEELEQDKEAL 738
A S ++ D + E ++ A E++ L E E T +K E LE + +
Sbjct: 574 GENKAMHFSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNA 633
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
++K ++ + + + TT + AE ++ + EI++ +++L+E ++
Sbjct: 634 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAE--LRECKMEIEDEKQELLEMDQ 691
Query: 799 DCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADN 858
+ + EL + + LD + +++ Q ++I+ E ++ +++ + L+ N
Sbjct: 692 ALKERNWELK------QRAAQVTHLDMTIREHRGEMEQ-KIIKLEGTLEKSELE-LKECN 743
Query: 859 EKLQTENKKLQLLKNAKSLRSDKALDL-NTKKTTQLENELKEALAKIKELEMICQDEKSE 917
+++++ N KLQ K + LR + + L N ++ +QL+ E++ ++KE+E + ++++
Sbjct: 744 KQIESLNDKLQNAK--EQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQY 801
Query: 918 KKVRFTEA 925
+ EA
Sbjct: 802 IATQCKEA 809
Score = 61.3 bits (142), Expect = 3e-08
Identities = 128/663 (19%), Positives = 277/663 (41%), Gaps = 61/663 (9%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKS----DILLRRLANIDTANKYTTGRSSEVLKL 322
KE + QIE L+ +++ ++ + EK S DI+ ++ ++++ ++ T E+ K
Sbjct: 325 KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQ-HHLESLDRLLTESKGEMKKE 383
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCE 382
K +E + L+++ T K+R+++S LE E + QL E +
Sbjct: 384 NMKKDEAL---KALQNQVSEETIKVRQLDSALEI--CKEELVLHLNQLEGN---KEKFEK 435
Query: 383 ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL---EQTIKNCRV--LSFK 437
+L ++E++ ++L +Q+ ++ +++ +++ ++TI+N + K
Sbjct: 436 QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK 495
Query: 438 LKKTERKADQ-LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
L+K K +Q L++++ +KL ++ + E +K Q+V T A +++ E+
Sbjct: 496 LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR--QKVIELTGTARQVKIEM 553
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSL---------TRGGSQEDPAQLLRDLQDSLE 547
+ + + +M + + K S T + + + L LQ S E
Sbjct: 554 DQYKEELSKMEKEIMHLKRDGENKAMHFSQLDMILDQTKTELEKKTNAVKELEKLQHSTE 613
Query: 548 READLREQLRNA-EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHA 606
E Q R E E N T Q + D + + E T +I++
Sbjct: 614 TELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYT-TIKDLTAEL 672
Query: 607 ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
E L +D+ +E + + +L T + E ++
Sbjct: 673 RECKMEIEDEKQELLEMDQALKERNWELKQRAAQV------THLDMTIREHRGEMEQKII 726
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
+L+ K+ NK IE+ ND + ++ E + ++ NEQE + L++
Sbjct: 727 KLEGTLEKSELE----LKECNK-QIESLNDKLQNAKEQL--REKEFIMLQNEQEISQLKK 779
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
++E +Q + ++ +KE I++ K + R L E+V+ E+
Sbjct: 780 EIERTQQRMKEMESVMKEQEQYIATQCKEAIDLGQKLR---------LTREQVQNSHTEL 830
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
E R + ++ +R+ ERL +EL + K L K + + +++ EA
Sbjct: 831 AEARHQQVQAQREIERLSSEL----EDMKQLSKEKDAHGNHLAEELGASKVREAHLEAR- 885
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK-ALDLNTKKTTQLENELKEALAKIK 905
++A+ + L A+ E L+ E ++++ + ++ K + D QL +L++A +++
Sbjct: 886 MQAEIKKLSAEVESLK-EAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELE 944
Query: 906 ELE 908
E +
Sbjct: 945 EAQ 947
Score = 58.8 bits (136), Expect = 2e-07
Identities = 172/895 (19%), Positives = 350/895 (39%), Gaps = 106/895 (11%)
Query: 714 LELNEQEATVLRRKVEELEQ--DKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNS 771
L+L +QE R ++ LE+ + LK+++ S +S + S+ SN R +
Sbjct: 57 LDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKY-QMSSFSNKEDRCIGCCEA 115
Query: 772 NKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
NKL I E+R KL KE + ++LHA L+ Q + + S ++S ++
Sbjct: 116 NKLV----------ISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSL 165
Query: 832 DLKRQLQVIEQEASVLRAKTQ-----SLEADNEKLQTENKKLQL-LKNAKSLRSDKALDL 885
+ + Q A ++ + Q E + ++L T ++L+ L ++ SD +++
Sbjct: 166 ETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNM 225
Query: 886 NTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXX 945
+T+Q + +E L K + + E ++K + K+ + + +
Sbjct: 226 -AHRTSQFQLIQEELLEKASNSSKL-ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAE 283
Query: 946 XXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG---- 1001
++ ++ + +K K L +++K +E LE ++
Sbjct: 284 LEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQ 343
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEID--------EIRSKLSKNDSEFTNEKNRLQTEIA 1053
+ K + +++ K + +D E++ + K D +N++ E
Sbjct: 344 QFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETI 403
Query: 1054 KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATS 1113
K++ +++ LE K+ LE Q K +EE+ + ++ +KN S
Sbjct: 404 KVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELK-----IKNH-S 457
Query: 1114 LQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDX 1173
LQ T + D TK+++ +KL +E+ K+
Sbjct: 458 LQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQEL---QKQRESS 514
Query: 1174 XXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDEL 1233
C+ + ++ +V + L T R++ IE+ K+EL
Sbjct: 515 AEKLRKMEEKCESAAHEADLKRQKV--------------IELTGTARQVKIEMDQYKEEL 560
Query: 1234 QARFIKTESKFITLEAEMRDLKADYENK----------ITSLESTIAAKDVHIKQLEDAL 1283
SK +E E+ LK D ENK + ++ + K +K+LE L
Sbjct: 561 --------SK---MEKEIMHLKRDGENKAMHFSQLDMILDQTKTELEKKTNAVKELE-KL 608
Query: 1284 RQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ-----DELNNAKIKLEK-------T 1331
+ +T + EA E++E Q D L A++ LE+
Sbjct: 609 QHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDL 668
Query: 1332 EAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKL 1391
AE K+E+ K +L +++ ++ + +E +++ + KL
Sbjct: 669 TAELRECKMEIEDEKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKL 728
Query: 1392 DRMRIAHDKDVKNKDAELATLKGKLKILEQNSG-------AGAKRITELKQEYEETVKKL 1444
+ + ++K + ++ +L KL+ ++ + I++LK+E E T +++
Sbjct: 729 EGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRM 788
Query: 1445 EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQ-AQGELLHVQKELSTALGEIKT 1503
+ ++ K + + + + + E + K RLT E+ Q + EL + + A EI+
Sbjct: 789 KEMESVMKEQEQYIATQCK--EAIDLGQKLRLTREQVQNSHTELAEARHQQVQAQREIER 846
Query: 1504 LQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRA 1558
L +L + + EK N +A E L G +V A L AR+ ++L A
Sbjct: 847 LSSEL-EDMKQLSKEKDAHGNHLA---EEL--GASKVREAHLEARMQAEIKKLSA 895
Score = 56.8 bits (131), Expect = 7e-07
Identities = 120/540 (22%), Positives = 222/540 (41%), Gaps = 45/540 (8%)
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
IQ +++ AS SSK +S+ T E Q + ++ +AA N + +
Sbjct: 235 IQEELLEKASN-SSKLESEMTKKCSQLLTLEKQLE---EKIVAYSSIAAKNA-ELEQELM 289
Query: 659 EDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
E NE + + T+ L+ A K+ +E + EK+ + + K + E
Sbjct: 290 EKNEKIRSLETNINTEHEKICLA-FEKAKKIHLEQHKEM-EKQIERLEAQLEKKDQQFKE 347
Query: 719 QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER 778
QE T+ L+QD + ++ L ++ N +L N+++EE
Sbjct: 348 QEKTM-----SMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEET 402
Query: 779 VKV--LEDEIDEVRKKLI----------EK-ERDCERLHAELSLAQKKPKTLIKSRSLDA 825
+KV L+ ++ +++L+ EK E+ ++ E+ QK+ K IK+ SL
Sbjct: 403 IKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELK--IKNHSLQE 460
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAKSLRSDKALD 884
+ +QNV L+ LQ +Q + LE KL+ + KL Q L+ + ++K
Sbjct: 461 TSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK 520
Query: 885 LNTK-KTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ K ++ E +LK K+ EL + K E E +K E + + K+
Sbjct: 521 MEEKCESAAHEADLKR--QKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKA 578
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVE-DLECEIGE 1002
K K +A K + T+LT LQ ++++E +L+ GE
Sbjct: 579 MHFSQLDMILDQTKTELEK--KTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE 636
Query: 1003 MYVVMKN-AGLSGKEMTAKTKLEKE---IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDV 1058
+ ++ L A+ LE++ I ++ ++L + E +EK L LK+
Sbjct: 637 LKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDEKQELLEMDQALKER 696
Query: 1059 NAKLE------GDKDVFANKYKA-LENENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
N +L+ D+ +++ +E + L + E+K QI L+ L+NA
Sbjct: 697 NWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNA 756
Score = 39.5 bits (88), Expect = 0.12
Identities = 63/394 (15%), Positives = 147/394 (37%), Gaps = 18/394 (4%)
Query: 1418 ILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEEL-------TGKYELLEEE-- 1468
+ +QN K+ + +Q +++L L +AE +L T +++L++EE
Sbjct: 181 VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL 240
Query: 1469 -HVVTKARLTVEKEQAQGELLHVQKELS---TALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
++L E + +LL ++K+L A I +L E N + ++
Sbjct: 241 EKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLET 300
Query: 1525 SIASLQERLCGGGWEVERARL--NARLDQRERELRAANDRRDV-LEHHHDXXXXXXXXXX 1581
+I + E++C + ++ L + ++++ L A +++D +
Sbjct: 301 NINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDII 360
Query: 1582 XXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMR 1641
E + ++ ++ ++ + E +
Sbjct: 361 CKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELV 420
Query: 1642 DELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKV 1701
L L +F ++ + + QK + +IKN +N I ++ + +
Sbjct: 421 LHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL-KIKNHSLQETSEQNVILQHTLQQQQQML 479
Query: 1702 ALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRA 1761
+ LED + SKL EL ++ S+ +L +M+ + E L +
Sbjct: 480 QQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKV 539
Query: 1762 -RVAGLATRMELAWHKERDEQQRLLQETSTLARD 1794
+ G A ++++ + ++E ++ +E L RD
Sbjct: 540 IELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 573
>X03741-1|CAA27381.1| 635|Homo sapiens protein ( Human cardiac mRNA
for myosin heavy chain light meromyosin region. ).
Length = 635
Score = 66.1 bits (154), Expect = 1e-09
Identities = 100/556 (17%), Positives = 227/556 (40%), Gaps = 51/556 (9%)
Query: 532 QEDPAQLLRDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
+ D Q +L+++ ++ A L+E E A C + + + D +V D+
Sbjct: 76 ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVE 133
Query: 591 ESETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFN 643
S ++ K + + K+K + ++ + +E + F Y
Sbjct: 134 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 193
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKET 702
H+ ++ ++E+ L QL T K+ A K+ +++A + E
Sbjct: 194 HL--ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL 251
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ + ++ LE N+ +A + R++ E+ E+ ++A + ++ + S +TS + T
Sbjct: 252 EHEEGKILRAQLEFNQIKAEIERKRQEKDEEMEQAKRNHLRVVDS-----LQTSLDAETR 306
Query: 763 ARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
+R K+ E +++E+ +L R+ AE K ++L+K
Sbjct: 307 SRNEALRVKKKM--------EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQ 354
Query: 823 LDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ-----TENKKLQLLKNAK 875
+ D + N DLK + ++E+ ++L+A+ + L A E+ + E + ++ + +
Sbjct: 355 IQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ 414
Query: 876 SLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
L S +N KK +++ +L + +++E C++ + + K T+A + LK
Sbjct: 415 LLHSQNTSLINQKK--KMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKK 471
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED 995
+Q Q L + A K K ++ K + +L+ +E
Sbjct: 472 EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEA 528
Query: 996 LECEIGEMYVVMKNAGLSGKEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+ E M+ + KE+T +T +L+ +D+++ K+ + + +
Sbjct: 529 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 588
Query: 1048 LQTEIAKLKDVNAKLE 1063
T ++K + V +L+
Sbjct: 589 ANTNLSKFRKVQHELD 604
Score = 53.6 bits (123), Expect = 7e-06
Identities = 118/654 (18%), Positives = 267/654 (40%), Gaps = 42/654 (6%)
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
+ L+R+LE+ +K L+ L+ D L ++ E + + G + + N
Sbjct: 11 QLGDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKARLQG---DLSKAN-- 65
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP 535
E+ Q + A++ EL EA K + + K S T+ Q +
Sbjct: 66 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI 125
Query: 536 AQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETV 595
L+ D++ S A L ++ RN ++ A KQ + + + + E +
Sbjct: 126 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST-ELFKL 184
Query: 596 TNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
N+ + + H + K ++ + I TE+ L H +RK
Sbjct: 185 KNAYEESLEH---LETFKRENKNLQEEISDLTEQ------LGSSGKTIH-ELEKVRKQLE 234
Query: 656 RVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK--ETDEADPAEMKLL 713
+ + +S L + + + L N++ E EK E ++A ++++
Sbjct: 235 AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKRQEKDEEMEQAKRNHLRVV 294
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
L R + E L + K+ ++ + E+ ++S + +A A++ + + +
Sbjct: 295 DSLQTSLDAETRSRNEAL-RVKKKMEGDLNEMEIQLSHANRMAA----EAQKQVKSLQSL 349
Query: 774 LAEERVKVLEDEI---DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
L + +++ L+D + D++++ + ER L AEL + + +SR L ++Q+
Sbjct: 350 LKDTQIQ-LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL--AEQEL 406
Query: 831 VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTE-NKKLQLLKNAKSLRSDKALDLNTKK 889
++ ++Q++ + + L + + ++AD +LQTE + +Q +NA+ ++ KA+
Sbjct: 407 IETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE-KAKKAITDAAMM 465
Query: 890 TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK-QXXXXXXXXXXX 948
+L+ E ++ A ++ ++ + + + R EA + K + Q
Sbjct: 466 AEELKKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEN 524
Query: 949 XXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
++K ++ +++ K + D L+L+ +V+ L+ ++ +
Sbjct: 525 ELEAEQKRNAESVKGMR-KSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAE 583
Query: 1009 NAGLSGKEMTAK-TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
A +K K++ E+DE + +S+ N+L+ AK +D+ K
Sbjct: 584 EAEEQANTNLSKFRKVQHELDEAEERADIAESQV----NKLR---AKSRDIGTK 630
Score = 47.2 bits (107), Expect = 6e-04
Identities = 99/529 (18%), Positives = 201/529 (37%), Gaps = 48/529 (9%)
Query: 989 LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTN---E 1044
L+K L+ EI ++ V ++ + + + K + +K + E + K ++ SE + E
Sbjct: 114 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 173
Query: 1045 KNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
L TE+ KLK NA E + + EN NL + LTE++ + I++L
Sbjct: 174 ARSLSTELFKLK--NAYEES-----LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHEL 226
Query: 1105 SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVD-NYTKIDQDKNKLLKEV 1163
K + + + + Q+ + Q+K++ +++
Sbjct: 227 EKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKRQEKDEEMEQA 286
Query: 1164 GDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLS 1223
++ D ++ + +R + + + L++ + R++
Sbjct: 287 KRNHLRVVDSLQTS---------LDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN-RMA 336
Query: 1224 IELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDAL 1283
E + LQ+ T+ I L+ +R D + I +E +++L +
Sbjct: 337 AEAQKQVKSLQSLLKDTQ---IQLDDAVR-ANDDLKENIAIVERRNNLLQAELEELRAVV 392
Query: 1284 RQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMA 1343
QT + +E E R Q + +A + +TE E + + A
Sbjct: 393 EQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNA 451
Query: 1344 QLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVK 1403
+ K+ A + E KE DT ER K + + D +
Sbjct: 452 EEKAKKA---------------ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHR 496
Query: 1404 NKDAELATLKGKLKILEQNSGAGAKRITELKQEYE---ETVKKLEHS-LALEKAEYEELT 1459
+AE LKG K L++ + EL+ E + E+VK + S +++ Y+
Sbjct: 497 LDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEE 556
Query: 1460 GKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKL 1508
+ LL + +V K +L V+ + Q E +++ +T L + + +Q +L
Sbjct: 557 DRKNLLRLQDLVDKLQLKVKAYKRQAE--EAEEQANTNLSKFRKVQHEL 603
Score = 46.0 bits (104), Expect = 0.001
Identities = 65/292 (22%), Positives = 117/292 (40%), Gaps = 19/292 (6%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL 343
R RV+K+ L + AN+ +V LQ + + +D L
Sbjct: 308 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 367
Query: 344 TQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXX 403
+ I +E R + Q ++E+LRA + E + E + + ++ L
Sbjct: 368 KENIAIVE-----RRNNLLQA-ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 421
Query: 404 XMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
+ + ++ AD S L+ E+E+ ++ CR K KK A + +E + + +
Sbjct: 422 SLINQKKKMDAD-LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 480
Query: 464 GGPDGMQRENRIKELEQEVARSTEVAL---RLQRELAEANSKFTGSNPSLMKVPQPETVK 520
M E IK+L+ + + ++AL + Q + EA + + + E+VK
Sbjct: 481 RMKKNM--EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVK 538
Query: 521 VSRSSLTR-----GGSQEDPAQLLR--DLQDSLEREADLREQLRNAEEETAN 565
R S R ++ED LLR DL D L+ + ++ EE AN
Sbjct: 539 GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN 590
Score = 41.1 bits (92), Expect = 0.039
Identities = 89/434 (20%), Positives = 173/434 (39%), Gaps = 45/434 (10%)
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+A+E + ++ L++ + ++++ ++ L++ K + E KQ
Sbjct: 99 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 158
Query: 1436 EYEETVKKLEHSLALEKAEYEELTGKYELLEE--EHVVTKARLTVEKEQAQGELLHVQKE 1493
+YEE+ +LE S ++ EL EE EH+ T R E + Q E+ + ++
Sbjct: 159 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR---ENKNLQEEISDLTEQ 215
Query: 1494 LSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRE 1553
L ++ I L EK+ + A EK E+Q+++ + L ++ RA+L +Q +
Sbjct: 216 LGSSGKTIHEL-EKVRKQLEA---EKMELQSALEEAEASLEHEEGKILRAQL--EFNQIK 269
Query: 1554 RELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXX 1613
E+ +D D E S+ +
Sbjct: 270 AEIERKRQEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE----ALRVKKKMEGDLNEM 325
Query: 1614 XIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMA 1673
I+ S R A + Q+ +++ LK Q+ R D+ K+ + ++
Sbjct: 326 EIQLSHANRMA------AEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER--- 376
Query: 1674 EIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCES----RLLASKLNTEL 1729
RN++ + EE R V E+ E EL E+ +LL S+ NT L
Sbjct: 377 ------------RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ-NTSL 423
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGL-ATRMELAWHKERDEQ---QRLL 1785
+++K + L+++Q+ + E +E + +A+ A A M KE+D +R+
Sbjct: 424 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 483
Query: 1786 QETSTLARDLRQTL 1799
+ +DL+ L
Sbjct: 484 KNMEQTIKDLQHRL 497
Score = 36.3 bits (80), Expect = 1.1
Identities = 113/599 (18%), Positives = 217/599 (36%), Gaps = 51/599 (8%)
Query: 1015 KEMTAKTKLEKEIDEIRSK---LSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFA- 1070
+E+ AK L + R L + E T K RLQ +++K A+ + A
Sbjct: 21 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKARLQGDLSKANSEVAQWRTKYETDAI 80
Query: 1071 NKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXX 1130
+ + LE L+ + + E ++ A+ + L K LQ + D M
Sbjct: 81 QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE---KTKHRLQNEIEDLMVDVERSNA 137
Query: 1131 XXXXXXXXXXXXXXQVDNYT-KIDQDKNKL------LKEVGDKTKKIGDXXXXXXXXXXX 1183
+ + K ++ +++L + + + K+ +
Sbjct: 138 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 197
Query: 1184 CKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESK 1243
KR K L +T + + +EL S +E +A E K
Sbjct: 198 FKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGK 257
Query: 1244 FITLEAEMRDLKADYENKITSLESTI-AAKDVHIK---QLEDALRQTTNDKYDEATSPVE 1299
+ + E +KA+ E K + + AK H++ L+ +L T + + +
Sbjct: 258 ILRAQLEFNQIKAEIERKRQEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK 317
Query: 1300 MV----EMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENX 1355
M EM Q ++ + + L+ T+ + A LK ++A +E
Sbjct: 318 MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERR 377
Query: 1356 XXXXXXXXXXXXXXSSYWENKAKELDTDL--QSER-KKLDRMRIAHDKDVKNKDAELATL 1412
E K + +L SER + L + K DA+L+ L
Sbjct: 378 NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQL 437
Query: 1413 KGKLKILEQ---NSGAGAKR-ITELKQEYEETVKKLEHSLALEKAEYE-ELTGK---YEL 1464
+ +++ Q N+ AK+ IT+ EE K+ + S LE+ + E T K + L
Sbjct: 438 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 497
Query: 1465 LEEEHVVTKA------RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTE 1518
E E + K +L + + EL QK + ++ ++ + ++ + + TE
Sbjct: 498 DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI--KELTYQTE 555
Query: 1519 K-----TEMQNSIASLQERLCGGGWEVERARLNA-----RLDQRERELRAANDRRDVLE 1567
+ +Q+ + LQ ++ + E A A + + + EL A +R D+ E
Sbjct: 556 EDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 614
>M81105-1|AAA59888.1| 1337|Homo sapiens cellular myosin heavy chain
protein.
Length = 1337
Score = 66.1 bits (154), Expect = 1e-09
Identities = 109/458 (23%), Positives = 194/458 (42%), Gaps = 63/458 (13%)
Query: 709 EMKLLLELNEQEATVLRRKVE--ELEQDKEALKKQVKELTSKISSVT--KTSAGSNTTAR 764
++K LL+++ QE ++ ++ E ++ + + A + ++ E+ + S + K A
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEV----RKKLIEKERDCERLHAELSLAQKKPKTLIKS 820
L + +L R+ + E++E+ ++ E+E C+ L AE +KK + I+
Sbjct: 893 TELCAEAEEL-RARLTAKKQELEEICHDLEARVEEEEERCQHLQAE----KKKMQQNIQE 947
Query: 821 RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD 880
++++ K QL+ + EA K + LE + L+ +N KL K L D
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEA-----KLKKLEEEQIILEDQNCKLA---KEKKLLED 999
Query: 881 KALDLNTKKTTQLENELKEALAKIKELEMICQDE----KSEKKVRFTEATKKE-----TD 931
+ + T T + E A K K MI E + EK+ + E T+++ TD
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 932 TLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKK 991
QA L ++++A + K KK +L + Q+ +
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ--KNMALKKIRELES--QISE 1115
Query: 992 MVEDLECEIGEMYVVMKNAGLSGKEMTA-KTKLEKEIDEIRSKL---SKNDSEFTNEKNR 1047
+ EDLE E K G+E+ A KT+LE +D ++ SK + E K
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT 1175
Query: 1048 LQTEI----AKLKDVNAK-----------LEGDKDVFANKYKA---LENENSNLSNQCKT 1089
L+ E A+++++ K LE K V AN KA LENE L+N+ K
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV 1235
Query: 1090 LTE-------EMKNREAQINKLSADLKNATSLQTTMSD 1120
L + + K EAQ+ +L ++T ++D
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD 1273
Score = 65.3 bits (152), Expect = 2e-09
Identities = 90/447 (20%), Positives = 191/447 (42%), Gaps = 27/447 (6%)
Query: 470 QRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG 529
++E + E+E+ + E L + L E + S K+ E ++
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMET--LQSQLMAEKLQLQEQLQAETELCAE- 898
Query: 530 GSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDI 589
++E A+L Q+ E DL ++ EEE C+ + +K+ M NI +
Sbjct: 899 -AEELRARLTAKKQELEEICHDLEARV---EEEEERCQHLQA----EKKKMQQNIQELE- 949
Query: 590 HESETVTNSIQNKMIHAASTPSSKEKSDSPPLSID----KTTEETQFHFDLPYLSIFNHM 645
+ E ++ Q + +T + +K + + ++ K +E + D N
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 646 AANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEA 705
K+ A+++ +E+++ L++ + ++ KL ++ + +D+ +A
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 706 DPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR 765
AE+K+ L E+E +VEE K K+++EL S+IS + + S +R
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL-QEDLESERASRN 1128
Query: 766 SLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
L EE ++ L+ E+++ ++ + E+++ +K + K+
Sbjct: 1129 KAEKQKRDLGEE-LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL-QT-ENKKLQLLKNAKSLRSDKAL 883
+ + ++ Q +E+ A L +T+ ++A+ EK QT EN++ +L K L K
Sbjct: 1188 QEMR----QKHSQAVEELAEQLE-QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 884 DLNTKKTTQLENELKEALAKIKELEMI 910
+ +K ++E +L+E K E E +
Sbjct: 1243 SEHKRK--KVEAQLQELQVKFNEGERV 1267
Score = 60.5 bits (140), Expect = 6e-08
Identities = 85/394 (21%), Positives = 168/394 (42%), Gaps = 18/394 (4%)
Query: 699 EKETDEADPAEMKLLLELNEQEATVLRRKVEE--LEQDKEALKKQVKELTSKISSVTKTS 756
E++ +E + A KL LE EA + + + E+ LE L K+ K L +I+ T T+
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT-TN 1007
Query: 757 AGSNTTARRSLTTNSNKLAEERVKVLEDEI---DEVRKKLIEKERDCERLHAELSLAQKK 813
+SL NK E + LE+ + ++ R++L + R E +LS +
Sbjct: 1008 LTEEEEKSKSLAKLKNK-HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 814 PKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS---VLRAKTQSLEADNEKLQTENKKLQL 870
+ I + + ++ +L+ L +E+EA+ + K + LE+ +LQ + + +
Sbjct: 1067 LQAQIAELKMQLAKKEE-ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 871 LKN-AKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKE 929
+N A+ + D +L KT +LE+ L A+ +EL + E + K E K
Sbjct: 1126 SRNKAEKQKRDLGEELEALKT-ELEDTLDSTAAQ-QELRSKREQEVNILKKTLEEEAKTH 1183
Query: 930 TDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL 989
++ + +A L+ K + + L K
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS 1243
Query: 990 KKMVEDLECEIGEMYVVMKNAGLSGKEMTAK-TKLEKEIDEIRSKLSKND---SEFTNEK 1045
+ + +E ++ E+ V E+ K TKL+ E+D + LS++D S+ T +
Sbjct: 1244 EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303
Query: 1046 NRLQTEIAKLKDVNAKLEGDKDVFANKYKALENE 1079
+ L++++ +++ + K + K K +E+E
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337
Score = 57.2 bits (132), Expect = 6e-07
Identities = 104/521 (19%), Positives = 208/521 (39%), Gaps = 37/521 (7%)
Query: 277 KQEVDILRKRCERVE-KEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+QE +++ K E V+ +EK RL ++T ++ + Q EL E+
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 901
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETL-CEELMDENEDMKKE 394
LR Q++ EI +LE R E + Q Q K + EE ++E E +++
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
Query: 395 LRDLXXXXXXMQDNFREDQ---ADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQE 451
L+ E+Q D+ L +E + + L + E K+ L +
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 452 KAEHEKKLLEIVGGPDGMQRENRIK-ELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
K +HE + ++ + ++RE + + ELE+ + + L ++AE ++ L
Sbjct: 1022 KNKHEAMITDL---EERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
K + ++R +E+ AQ L+ E E+ + E + E E A+ +
Sbjct: 1079 AKKEEELQAALAR-------VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA- 1130
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
+KQ E E + +++ + A+ + K + + KT EE
Sbjct: 1131 -----EKQKRDLG------EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ + + + + A ++E+ + + L+K A + + K+
Sbjct: 1180 AKTHE-AQIQEMRQKHSQAVEELAEQLEQ-TKRVKANLEK-AKQTLENERGELANEVKVL 1236
Query: 691 IETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKI 749
++ D++ K EA E+++ E+ T L KV +L+ + + + + + SK
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 750 SSVTKTSAGSNT----TARRSLTTNSNKLA-EERVKVLEDE 785
S +TK + + T N KL+ ++K +EDE
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337
Score = 53.6 bits (123), Expect = 7e-06
Identities = 85/398 (21%), Positives = 159/398 (39%), Gaps = 36/398 (9%)
Query: 1432 ELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE-----EHVVTKARLTVEKEQAQGE 1486
E+ + EE VK E LA E E T + +L+ E E + + L E E+ +
Sbjct: 846 EMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRAR 905
Query: 1487 LLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLN 1546
L ++EL +++ E+ EK +MQ +I L+E+L E E AR
Sbjct: 906 LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL----EEEESARQK 961
Query: 1547 ARLDQ--RERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXX 1604
+L++ E +L+ + + +LE + ++ +
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 1605 XXXXXXXXXXIEQ---SEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNY 1661
+E+ E+ ++ E+ T+ + EG + D++ L Q++ + +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 1662 KQML---------EAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVAL----LEQQV 1708
++ L EAAQK+MA K + ++I E RNK L +++
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141
Query: 1709 ACLEDELCESRLLASKLNTELVSEKSSAEVRL----AEMQSRLNEYEEERLLSSGRARVA 1764
L+ EL E L ++ EL S K EV + E +++ +E + + + V
Sbjct: 1142 EALKTEL-EDTLDSTAAQQELRS-KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 1765 GLATRMELAWHKERD---EQQRLLQETSTLARDLRQTL 1799
LA ++E + + +Q L E LA +++ L
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
Score = 44.8 bits (101), Expect = 0.003
Identities = 100/519 (19%), Positives = 196/519 (37%), Gaps = 44/519 (8%)
Query: 981 TDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSE 1040
T + LQ+ + E++ + E+ V + K++ A+ +L E++ ++S+L +
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVRE------KQLAAENRLT-EMETLQSQLMAEKLQ 884
Query: 1041 FTNEKNRLQTEI-AKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREA 1099
E+ + +TE+ A+ +++ A+L K LE +C+ L E K +
Sbjct: 885 L-QEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQ 943
Query: 1100 QINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDK--- 1156
I +L L+ S + + ++ K+ +D+
Sbjct: 944 NIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003
Query: 1157 -NKLLKEVGDKTKKIGDXXXXXXXXXXXC----KRIEKQLSTRKDRVTXXXXXXXXXXXQ 1211
L E +K+K + +R EKQ + Q
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ 1063
Query: 1212 AVVLANTHRRLSIELTSEKDELQARFIKTES----KFITLEAEMRDLKADYENKITSLES 1267
L L ++L +++ELQA + E K + L+ ++R+L++ LES
Sbjct: 1064 IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLES 1122
Query: 1268 TIAAKDVHIKQLED------ALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDEL 1321
A+++ KQ D AL+ D D + E+ R + +
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182
Query: 1322 NNAKIKLEKTE----AESSAAKLEMAQ-LKSDLAK----LENXXXXXXXXXXXXXXXSSY 1372
+ A+I+ + + E A +LE + +K++L K LEN
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 1373 WENKAKELDTDLQSERKKL---DRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKR 1429
E+K K+++ LQ + K +R+R V EL + G L + S K
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 1430 ITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEE 1468
+ L+ + ++T + L+ E + L+ K + +E+E
Sbjct: 1303 FSALESQLQDTQELLQE----ENRQKLSLSTKLKQVEDE 1337
Score = 43.2 bits (97), Expect = 0.010
Identities = 65/298 (21%), Positives = 122/298 (40%), Gaps = 32/298 (10%)
Query: 1246 TLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRX 1305
TL++++ K + ++ + E+ + A+ ++ A +Q + + + VE E R
Sbjct: 873 TLQSQLMAEKLQLQEQLQA-ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERC 931
Query: 1306 XXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXX 1365
Q + + +LE+ E+ +LE ++ L KLE
Sbjct: 932 QHLQAEKKKM--QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCK 989
Query: 1366 XXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGA 1425
E++ E T+L E +K LA LK K + + +
Sbjct: 990 LAKEKKLLEDRIAEFTTNLTEEEEK---------------SKSLAKLKNKHEAMITDLEE 1034
Query: 1426 GAKRITELKQEYEETVKKLE-------HSLALEKAEYEELTGKYELLEEEHVVTKARLTV 1478
+R + +QE E+T +KLE +A +A+ EL K +L ++E + A V
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL--KMQLAKKEEELQAALARV 1092
Query: 1479 EKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWN---TEKTEMQNSIASLQERL 1533
E+E AQ + K++ +I LQE L +E A+ N +K ++ + +L+ L
Sbjct: 1093 EEEAAQKNM--ALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Score = 42.7 bits (96), Expect = 0.013
Identities = 66/334 (19%), Positives = 129/334 (38%), Gaps = 26/334 (7%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
E + L K +N E + +ER RR + +E EKT R + S+ D +Q +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
LK + + ++E + QI L+++++ R
Sbjct: 1071 ----IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 287 CERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKLQQKVN--------ELTTHNED 335
+ EK+K D+ L ++ T + K +Q+VN E TH
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 336 LRDEKKHLTQKIREIESELE----TRPSTEAQTRQIEQLRAKLL-AAETLCEELMDENED 390
+++ ++ +Q + E+ +LE + + E + +E R +L + L + D
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246
Query: 391 MKK---ELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
KK +L++L + R + AD+ + L+ EL+ K K +
Sbjct: 1247 RKKVEAQLQELQVKFNE-GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQE 481
LE + + ++ L E + ++K++E E
Sbjct: 1306 LESQLQDTQELLQE--ENRQKLSLSTKLKQVEDE 1337
>D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein.
Length = 1388
Score = 66.1 bits (154), Expect = 1e-09
Identities = 96/414 (23%), Positives = 175/414 (42%), Gaps = 40/414 (9%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALK----KQVKELTSKISS------VT 753
E D K+LL E E L+ + +LE++K ++ Q+K + + T
Sbjct: 652 EEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKAT 711
Query: 754 KTSAGSNTTARRSLT-TNSNKLAEERVKVLEDEI--DEVRKKLIEKERDCERLHAELSLA 810
K S+ S + E K+LE+ +V L+E E+ C L +L +
Sbjct: 712 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQS 771
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
Q+K L+K + + D +N+ LK IEQE L+ +++ T +
Sbjct: 772 QQKINELLKQKDVLNEDVRNLTLK-----IEQETQKRCLTQNDLKMQTQQVNTLKMSEKQ 826
Query: 871 LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK-KE 929
LK + + ++L K+ +L E ++A ++KEL+ + E+ + T+ + KE
Sbjct: 827 LKQENNHLMEMKMNLE-KQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKE 885
Query: 930 TDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL 989
K+K Q + K D+++ + ++ +D L+
Sbjct: 886 ECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSD----LEK 941
Query: 990 KKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQ 1049
+K++++L EI EM K +E+T K ++E L+ + + NEK L
Sbjct: 942 EKIMKEL--EIKEMMARHK------QELTEKDATIASLEETNRTLTSDVANLANEKEELN 993
Query: 1050 TEIAKLKDVNAKLE--GDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQI 1101
KLKDV +L D+++ A KA + E L+ +TL + N+ A+I
Sbjct: 994 N---KLKDVQEQLSRLKDEEISAAAIKA-QFEKQLLTE--RTLKTQAVNKLAEI 1041
Score = 65.7 bits (153), Expect = 2e-09
Identities = 131/637 (20%), Positives = 277/637 (43%), Gaps = 66/637 (10%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIR-----------EIESELETRPSTEAQ 363
++ E ++Q+K+ L H + K+ L QK + E+E E+ R S E+
Sbjct: 438 KNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESA 497
Query: 364 TRQIEQLRAKLLAAETLCEELMDENEDMKKEL-RDLXXXXXXMQDNFREDQADEYSSLR- 421
RQ+E+ +A L + D D K+ L D+ ++D + +Q + S+ +
Sbjct: 498 LRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKV 557
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKE---- 477
+L++ + L L+ A +L + +AE K++ ++ +Q +N + E
Sbjct: 558 NQLQRQLDETNAL---LRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKL 614
Query: 478 -LEQE---VARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE 533
LE+E + + E R + +E + G L + + + +++ L + QE
Sbjct: 615 KLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQE 674
Query: 534 DPAQLLRDLQD-SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
L ++ + ++ L+ ++ E+E A K DK + ++I + +S
Sbjct: 675 RFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHK-ATKARLADKNKIYESI---EEAKS 730
Query: 593 ETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRK 652
E + ++ K++ + K+K ++ L +K + DL + N L K
Sbjct: 731 EAM-KEMEKKLLEERTL---KQKVENLLLEAEKRC--SLLDCDLKQ----SQQKINELLK 780
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL 712
+ ED +L L++++ + + R L+ N L ++T N K +++ E
Sbjct: 781 QKDVLNEDVRNLTLKIEQ---ETQKRCLT----QNDLKMQTQQVNTLKMSEKQLKQENNH 833
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L+E+ L ++ EL ++++ Q+KEL ++ + S T R
Sbjct: 834 LMEMKMN----LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVR-----ELK 884
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
+ EE+ K L E+ + +K+ ++ ERD E++L + + L +RS+ +++
Sbjct: 885 EECEEKTK-LGKELQQ-KKQELQDERDSLAAQLEITLTKADSEQL--ARSIAEEQYSDLE 940
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
++ ++ +E + + R K + E D E L + +L ++K +LN K
Sbjct: 941 KEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKE-ELNNKL--- 996
Query: 893 LENELKEALAKIKELEMICQDEKSE-KKVRFTEATKK 928
+++E L+++K+ E+ K++ +K TE T K
Sbjct: 997 --KDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLK 1031
Score = 57.2 bits (132), Expect = 6e-07
Identities = 142/755 (18%), Positives = 293/755 (38%), Gaps = 92/755 (12%)
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
+ ++ + K LE SN + L ++ K+ ++ K + +L+ +L+ +
Sbjct: 434 IQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKS 493
Query: 1118 MSDCMXXXXXXXXXXXXXXXXXXXXXX-QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + + D ++ D N L ++ D K+ +
Sbjct: 494 VESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQIS 553
Query: 1177 XXXXXXXCKRIEKQ---LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEK 1230
+++++ L T D Q L + +R L + L + K
Sbjct: 554 TEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAK 613
Query: 1231 DELQARFIKTESKFITLEAEMRD------LKADYENKITSLESTIAAKDVHIKQLEDALR 1284
+L+ FI +S LE+E RD + D + +I LE + + + ++E R
Sbjct: 614 LKLEKEFINLQS---ALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKR 670
Query: 1285 QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQ 1344
Q +++ + +E+ Q+E + K + +E A+
Sbjct: 671 QL-QERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAK 729
Query: 1345 LKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN 1404
++ + ++E E + LD DL+ ++K++ + KDV N
Sbjct: 730 SEA-MKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINEL--LKQKDVLN 786
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+D TLK +EQ + +LK + ++ V L+ S EK +L
Sbjct: 787 EDVRNLTLK-----IEQETQKRCLTQNDLKMQTQQ-VNTLKMS---EK----------QL 827
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
+E + + + ++ +EK+ A+ ++KE A G++K LQ++L E KT+
Sbjct: 828 KQENNHLMEMKMNLEKQNAE-----LRKERQDADGQMKELQDQLEAEQYFSTLYKTQ--- 879
Query: 1525 SIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
+ L+E C E+ +L L Q+++EL+ D RD L
Sbjct: 880 -VRELKEE-C-----EEKTKLGKELQQKKQELQ---DERDSL--------AAQLEITLTK 921
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
D E++++ I++ K E+T+ + + ++ +
Sbjct: 922 ADSEQLAR--SIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEK----DATIASLEETN 975
Query: 1645 KSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALL 1704
++L + V+ E++ L+ Q+ ++ +K+ + SA +I + E++ + L
Sbjct: 976 RTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAA----AIKAQFEKQLLTERTLK 1031
Query: 1705 EQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
Q V ++L E ++ K E V + +VR E ++R E L S R ++
Sbjct: 1032 TQAV----NKLAE--IMNRK---EPVKRGNDTDVRRKEKENRKLHME----LKSEREKL- 1077
Query: 1765 GLATRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
T+ + + KE +E Q + E S + +L+ TL
Sbjct: 1078 ---TQQMIKYQKELNEMQAQIAEESQIRIELQMTL 1109
Score = 57.2 bits (132), Expect = 6e-07
Identities = 85/413 (20%), Positives = 180/413 (43%), Gaps = 38/413 (9%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRC--ERVEKEKSDILLRRLANIDTANKYTTGRSSE 318
L D N K Y+ E + + + K+ ER K+K + LL A K + +
Sbjct: 715 LADKN-KIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLE------AEKRCSLLDCD 767
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKI-REIESELETRPSTEAQTRQIEQLR--AKLL 375
+ + QQK+NEL + L ++ ++LT KI +E + T+ + QT+Q+ L+ K L
Sbjct: 768 LKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQL 827
Query: 376 AAET--LCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSL-RRELEQTIK 429
E L E M+ +N +++KE +D +QD +Q +S+L + ++ + +
Sbjct: 828 KQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ--YFSTLYKTQVRELKE 885
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEV- 488
C + K+ ++K +L+ E+ +L + D Q I E + ++
Sbjct: 886 ECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIM 945
Query: 489 -ALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
L ++ +A + T + ++ + + + +LT D A L + ++
Sbjct: 946 KELEIKEMMARHKQELTEKDATIASLEE------TNRTLT-----SDVANLANEKEELNN 994
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQVMTD-NIVTCDIHESETVTNSIQNKMIHA 606
+ D++EQL ++E + + +KQ++T+ + T +++ + N + +
Sbjct: 995 KLKDVQEQLSRLKDEEISAAAIKAQ--FEKQLLTERTLKTQAVNKLAEIMNR-KEPVKRG 1051
Query: 607 ASTPSSKEKSDSPPLSID-KTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
T +++ ++ L ++ K+ E + Y N M A ++ R+E
Sbjct: 1052 NDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIE 1104
Score = 55.6 bits (128), Expect = 2e-06
Identities = 118/627 (18%), Positives = 261/627 (41%), Gaps = 42/627 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCE--RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ- 323
+ ++ + LK +++ L+KR + ++ EK + L R+L + + + ++ + K Q
Sbjct: 527 RNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQA 586
Query: 324 ---QKVNELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQ-------IEQLRA 372
+++ +L ++N DL+D+ L ++E E + + + E++ R I L+
Sbjct: 587 ESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQG 646
Query: 373 KLLAAETLCEE---LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
++ E + L+ + E K++L++ + N D + +++ LEQ
Sbjct: 647 RICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEA 706
Query: 430 NCRVLSFKLKKTERKADQLEQEKA----EHEKKLLEIVGGPDGMQRENRIKELEQEVARS 485
+ +L + + +E+ K+ E EKKLLE + EN + E E+ +
Sbjct: 707 EHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLE--ERTLKQKVENLLLEAEKRCSLL 764
Query: 486 TEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGG--SQEDPAQLLRDLQ 543
+ Q+++ E + N + + + + LT+ Q L+ +
Sbjct: 765 DCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSE 824
Query: 544 DSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNK 602
L++E + L E N E++ A ++ + + D + + T + K
Sbjct: 825 KQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELK 884
Query: 603 MIHAASTPSSKE-KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
T KE + L ++ + Q L +A + + + +E++
Sbjct: 885 EECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKAD-SEQLARSIAEEQYSDLEKEK 943
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L++K+M AR ++ A S+E N + + +L +L + +
Sbjct: 944 IMKELEIKEM--MARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQE 1001
Query: 722 TVLRRKVEELEQD--KEALKKQ-VKELTSKISSVTKTSAGSN--TTARRSLTTNSNKLAE 776
+ R K EE+ K +KQ + E T K +V K + N +R T+ + +
Sbjct: 1002 QLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEK 1061
Query: 777 ERVKV---LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDL 833
E K+ L+ E +++ +++I+ +++ + A+ +A++ + +LD+ D L
Sbjct: 1062 ENRKLHMELKSEREKLTQQMIKYQKELNEMQAQ--IAEESQIRIELQMTLDSKDSDIEQL 1119
Query: 834 KRQLQV--IEQEASVLRAKTQSLEADN 858
+ QLQ I ++S + + EAD+
Sbjct: 1120 RSQLQALHIGLDSSSIGSGPGDAEADD 1146
Score = 48.8 bits (111), Expect = 2e-04
Identities = 142/723 (19%), Positives = 278/723 (38%), Gaps = 87/723 (12%)
Query: 827 DQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN 886
++++ +++++L +E+ S + Q+ E +K ++ N +L+ K AK L + L +
Sbjct: 439 NEESQEIQKKLYTLEEHLS---NEMQAKEELEQKCKSVNTRLE--KTAKELEEEITLRKS 493
Query: 887 TKKTT-QLENELKEALAKIKELEMICQ-DEKSEKKVRF---TEATKKETDTLKSKQXXXX 941
+ QLE E +AL + K E + D +++KK + K + + LK +
Sbjct: 494 VESALRQLERE--KALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQ 551
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
A L++ D A + K T+ + K ++ LE
Sbjct: 552 ISTEKVNQLQRQLDETNALLRTESDTAARLRK-----------TQAESSKQIQQLESNNR 600
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
++ KN L TAK KLEKE ++S L + T+ + ++ +
Sbjct: 601 DLQD--KNCLLE----TAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEED 654
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
L+ K + A +E E L + L +E N E ++ LK +Q ++
Sbjct: 655 LKNGKILLAK----VELEKRQLQERFTDLEKEKSNMEID---MTYQLK---VIQQSLEQ- 703
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+ Y I++ K++ +KE+ KK+ +
Sbjct: 704 ---------EEAEHKATKARLADKNKIYESIEEAKSEAMKEM---EKKLLEERTLKQKVE 751
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
EK+ S + Q VL R L++++ E T+
Sbjct: 752 NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQE----------TQ 801
Query: 1242 SKFITLEAEMRDLKADYE--NKITSLESTIAAKDVHIKQLEDAL-RQTTNDKYDEATSPV 1298
+ +T DLK + N + E + ++ H+ +++ L +Q + + +
Sbjct: 802 KRCLT----QNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADG 857
Query: 1299 EMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXX 1358
+M E++ + ++ K E+ E ++ K E+ Q K +L +
Sbjct: 858 QMKELQDQLEAEQYFSTLYKTQVRELK---EECEEKTKLGK-ELQQKKQELQDERDSLAA 913
Query: 1359 XXXXXXXXXXXSSYWENKAKELDTDLQSER--KKLD--RMRIAHDKDVKNKDAELATLKG 1414
+ A+E +DL+ E+ K+L+ M H +++ KDA +A+L+
Sbjct: 914 QLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEE 973
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKL------EHSLALEKAEYEELTGKYELLEEE 1468
+ L + A EL + ++ ++L E S A KA++E+ L+ +
Sbjct: 974 TNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQ 1033
Query: 1469 HVVTKARLTVEKEQAQG----ELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
V A + KE + ++ +KE E+K+ +EKL + + E EMQ
Sbjct: 1034 AVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQA 1093
Query: 1525 SIA 1527
IA
Sbjct: 1094 QIA 1096
Score = 43.2 bits (97), Expect = 0.010
Identities = 123/611 (20%), Positives = 235/611 (38%), Gaps = 64/611 (10%)
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE----RVKVL 782
K LE D +LK Q+++L + + ++ N R+ TN+ E R++
Sbjct: 525 KKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKT 584
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQ-KKPKTLIKSRSLDASDQQN----VDLKRQL 837
+ E + ++L RD + + L A+ K K I +S S++++ ++ L
Sbjct: 585 QAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDL 644
Query: 838 Q--VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT--KKTTQL 893
Q + E + K + + EK Q + + L K ++ D L + Q
Sbjct: 645 QGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQE 704
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKK--ETDTLKSK-QXXXXXXXXXXXXX 950
E E K A++ + I + + K E KK E TLK K +
Sbjct: 705 EAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLL 764
Query: 951 XXXXXXXQATLKSL--KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
Q + L + D + K T K L + DL+ + ++ +
Sbjct: 765 DCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQ--NDLKMQTQQVNTLKM 822
Query: 1009 NAGLSGKE----MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQ----------TEIAK 1054
+ +E M K LEK+ E+R + D + +++L+ T++ +
Sbjct: 823 SEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRE 882
Query: 1055 LK-DVNAKLEGDKDVFANKYKALENENSNLSNQCK-TLT----EEMKN--REAQINKLSA 1106
LK + K + K++ K + L++E +L+ Q + TLT E++ E Q + L
Sbjct: 883 LKEECEEKTKLGKEL-QQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEK 941
Query: 1107 D-LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGD 1165
+ + ++ M+ V N ++ N LK+V +
Sbjct: 942 EKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQE 1001
Query: 1166 KTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXX--XXXXXXXXXQAVVLAN------ 1217
+ ++ D + EKQL T + T + V N
Sbjct: 1002 QLSRLKDEEISAAAIKA---QFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRR 1058
Query: 1218 ---THRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKI-TSLESTIAAKD 1273
+R+L +EL SE+++L + IK + + ++A++ + E++I L+ T+ +KD
Sbjct: 1059 KEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAE-----ESQIRIELQMTLDSKD 1113
Query: 1274 VHIKQLEDALR 1284
I+QL L+
Sbjct: 1114 SDIEQLRSQLQ 1124
>BC080545-1|AAH80545.1| 498|Homo sapiens MYH11 protein protein.
Length = 498
Score = 66.1 bits (154), Expect = 1e-09
Identities = 82/396 (20%), Positives = 161/396 (40%), Gaps = 17/396 (4%)
Query: 775 AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLK 834
AE R K E + + + L E E L + + + + L+ S+ D + +L+
Sbjct: 2 AEAREK--ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK--DDVGKNVHELE 57
Query: 835 RQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLE 894
+ + +E + + KTQ E ++E TE+ KL+L N ++L+ DL + Q E
Sbjct: 58 KSKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNE 114
Query: 895 NELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXX 954
+ ++ ++ E E +DE+ ++ + K E D LK +
Sbjct: 115 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQL 173
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
QA +K D Q+ + + T + +K + LE ++ ++ + A +
Sbjct: 174 RKLQAQMK----DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 229
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK 1074
K+ A + E+ +E+ S LS ++ +EK RL+ IA+L++ + +G+ + +++ +
Sbjct: 230 KQ--ADLEKEELAEELASSLSGRNA-LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 286
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXX 1134
+ LSN+ T + E+ +L K S M +
Sbjct: 287 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAA 344
Query: 1135 XXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKI 1170
QV+ + Q K LK+ K K+I
Sbjct: 345 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 380
Score = 60.5 bits (140), Expect = 6e-08
Identities = 68/305 (22%), Positives = 131/305 (42%), Gaps = 20/305 (6%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
EY+ ++E +++ + +++E + D+ L+ D+A K ++ KLQ ++
Sbjct: 126 EYETELEDERKQRALAAAAKKKLEGDLKDLELQA----DSAIKGREEAIKQLRKLQAQMK 181
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
+ ED R + + +E E + + S EA Q+++ L AAE ++ E
Sbjct: 182 DFQRELEDARASRDEIFATAKENEKKAK---SLEADLMQLQE---DLAAAERARKQADLE 235
Query: 388 NEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQ 447
E++ +EL +QD R +A + L ELE+ N +S +++K ++A+Q
Sbjct: 236 KEELAEELASSLSGRNALQDEKRRLEA-RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 294
Query: 448 LEQEKAEHEKKLLEIVGGPDGMQREN-----RIKELEQEVA---RSTEVALRLQ-RELAE 498
L E A + ++R+N ++ E+E V +ST AL + +L E
Sbjct: 295 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 354
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN 558
+ + K + + K+ L ++ Q + R L+ QL
Sbjct: 355 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 414
Query: 559 AEEET 563
AEEE+
Sbjct: 415 AEEES 419
Score = 59.3 bits (137), Expect = 1e-07
Identities = 92/487 (18%), Positives = 198/487 (40%), Gaps = 31/487 (6%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLL 375
+E + + K L E+ + K+ L + + +++E+E S++ + + +L
Sbjct: 2 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 61
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLS 435
A ET EE+ + E+++ EL+ ++ N + + L+ EQ + R L
Sbjct: 62 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 121
Query: 436 FKLKKTERKADQLEQEKA---------EHEKKLLEIVGGPDGMQRENRIKELEQEVARST 486
+L + E + + +++A E + K LE+ RE IK+L + A+
Sbjct: 122 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 181
Query: 487 EVALRLQRELAEANSKFTGSNPSLMKVPQPET----VKVSRSSLTRGGSQED--PAQLLR 540
+ L+ A + F + + K E ++ ++ R Q D +L
Sbjct: 182 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 241
Query: 541 DLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQ 600
+L SL L+++ R E A ++ + + M+D + ++E ++N +
Sbjct: 242 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT-QQAEQLSNELA 300
Query: 601 NKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEED 660
+ A S++++ + + E + + S + A + + +VE++
Sbjct: 301 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK-IAQLEEQVEQE 359
Query: 661 NESLLLQLKKMATKARSRK--LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE 718
K + K + K L K++ + ++ E A ++K LE E
Sbjct: 360 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY---KEQAEKGNARVKQLKRQLEEAE 416
Query: 719 QEAT-------VLRRKVEELEQDKEALKKQVKELTSKISSVTKTS-AGSNTTARRSLTTN 770
+E+ L+R+++E + EA+ ++V L SK+ +TS S + R + N
Sbjct: 417 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIEN 476
Query: 771 SNKLAEE 777
++ EE
Sbjct: 477 ADGSEEE 483
Score = 45.6 bits (103), Expect = 0.002
Identities = 86/459 (18%), Positives = 183/459 (39%), Gaps = 17/459 (3%)
Query: 423 ELEQTIKNCRVLSFK--LKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQ 480
E E K + LS L++ ++LE+ + ++ ++V D + + + ELE+
Sbjct: 1 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN--VHELEK 58
Query: 481 EVARSTEVALR-LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLL 539
R+ E + ++ +L E + + + +++ + E +
Sbjct: 59 S-KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 117
Query: 540 RDLQDSL-EREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
R LQ L E E +L ++ R A K+ D ++ D+ + E+
Sbjct: 118 RQLQRQLHEYETELEDE-RKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRK 175
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
+Q +M S + K E+ + + + +AA + A +E
Sbjct: 176 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 235
Query: 659 EDN--ESLLLQLK-KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLE 715
++ E L L + A + R+L + +E N E +D A + +
Sbjct: 236 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-Q 294
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
L+ + AT R ++ E ++ L++Q KEL SK+ + + +L +L
Sbjct: 295 LSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL- 352
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
EE+V+ E K L +K++ + + ++ ++K K ++ + + + LKR
Sbjct: 353 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVE-DERKMAEQYKEQA-EKGNARVKQLKR 410
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA 874
QL+ E+E+ + A + L+ + ++ N+ + NA
Sbjct: 411 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 449
Score = 43.6 bits (98), Expect = 0.007
Identities = 77/408 (18%), Positives = 160/408 (39%), Gaps = 35/408 (8%)
Query: 961 LKSLKDDAQKSFKPRIPKKPTDLTTKLQ-LKKMVEDLECEI-----GEMYVVMKNAGLSG 1014
L S KDD K+ + K L T+++ +K +E+LE E+ ++ + + L G
Sbjct: 42 LVSSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 100
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK 1074
+ +++ +E R +L + E+ E + + A KLEGD K
Sbjct: 101 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-------LK 153
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXX 1134
LE + + + ++++ +AQ+ +L++A + + +
Sbjct: 154 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 213
Query: 1135 XXXXXXXXXXQVDNYTK-IDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLST 1193
+ K D +K +L +E+ ++E++L
Sbjct: 214 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 273
Query: 1194 RKDRVTXXXXXXXXXXXQAVVLANTHRRLSIEL-TSEKDELQARFIKTESKFITLEAEMR 1252
+ + QA L+N L+ E T++K+E + ++ ++K L +++
Sbjct: 274 EQGNMEAMSDRVRKATQQAEQLSN---ELATERSTAQKNESARQQLERQNK--ELRSKLH 328
Query: 1253 DLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATS------PVEMVEMRXX 1306
+++ ++K +STIAA + I QLE+ + Q +K S ++ + ++
Sbjct: 329 EMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 385
Query: 1307 XXXXXXXXXXXQDELNNAKIK-----LEKTEAESSAAKLEMAQLKSDL 1349
Q E NA++K LE+ E ES +L+ +L
Sbjct: 386 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 433
Score = 41.1 bits (92), Expect = 0.039
Identities = 25/114 (21%), Positives = 56/114 (49%), Gaps = 5/114 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+++ + + ++Q+E +E K ++ +K+ +ILL+ ++ K + K
Sbjct: 345 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEK 400
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKL 374
+V +L E+ +E + + R+++ EL E S EA R++ L++KL
Sbjct: 401 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 454
Score = 39.9 bits (89), Expect = 0.091
Identities = 78/414 (18%), Positives = 164/414 (39%), Gaps = 29/414 (7%)
Query: 1383 DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVK 1442
D+ +L++ + A + ++ +L L+ +L+ E + LK ++E ++
Sbjct: 48 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 107
Query: 1443 KLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIK 1502
+ ++ + + +YE E+ +A K++ +G+L ++ + +A+ +
Sbjct: 108 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 167
Query: 1503 TLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERAR-LNARLDQRERELRAAND 1561
++L A + E++++ AS E ++A+ L A L Q + +L AA
Sbjct: 168 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 227
Query: 1562 RRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKA 1621
R + + + + +R S++
Sbjct: 228 ARKQADLEKEELAEELASSLSGRNALQ--DEKRRLEARIAQLEEELEEEQGNMEAMSDRV 285
Query: 1622 RKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKS 1681
RKA T + ++ T R + N+ +R + ER N K++ + + E++ KS
Sbjct: 286 RKA--TQQAEQLSNELATERSTAQK--NESARQQLERQN-KEL----RSKLHEMEGAVKS 336
Query: 1682 ARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLA 1741
+++I++ + K+A LE+QV E E E + L + +K E+ L
Sbjct: 337 K--FKSTIAALEA-----KIAQLEEQV---EQEAREKQAATKSLKQK---DKKLKEILLQ 383
Query: 1742 EMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
R + + G ARV L ++E A +E QR+ L R+L
Sbjct: 384 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEA----EEESQRINANRRKLQREL 433
>AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein.
Length = 1428
Score = 66.1 bits (154), Expect = 1e-09
Identities = 96/414 (23%), Positives = 175/414 (42%), Gaps = 40/414 (9%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALK----KQVKELTSKISS------VT 753
E D K+LL E E L+ + +LE++K ++ Q+K + + T
Sbjct: 692 EEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKAT 751
Query: 754 KTSAGSNTTARRSLT-TNSNKLAEERVKVLEDEI--DEVRKKLIEKERDCERLHAELSLA 810
K S+ S + E K+LE+ +V L+E E+ C L +L +
Sbjct: 752 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQS 811
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
Q+K L+K + + D +N+ LK IEQE L+ +++ T +
Sbjct: 812 QQKINELLKQKDVLNEDVRNLTLK-----IEQETQKRCLTQNDLKMQTQQVNTLKMSEKQ 866
Query: 871 LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK-KE 929
LK + + ++L K+ +L E ++A ++KEL+ + E+ + T+ + KE
Sbjct: 867 LKQENNHLMEMKMNLE-KQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKE 925
Query: 930 TDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQL 989
K+K Q + K D+++ + ++ +D L+
Sbjct: 926 ECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSD----LEK 981
Query: 990 KKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQ 1049
+K++++L EI EM K +E+T K ++E L+ + + NEK L
Sbjct: 982 EKIMKEL--EIKEMMARHK------QELTEKDATIASLEETNRTLTSDVANLANEKEELN 1033
Query: 1050 TEIAKLKDVNAKLE--GDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQI 1101
KLKDV +L D+++ A KA + E L+ +TL + N+ A+I
Sbjct: 1034 N---KLKDVQEQLSRLKDEEISAAAIKA-QFEKQLLTE--RTLKTQAVNKLAEI 1081
Score = 65.7 bits (153), Expect = 2e-09
Identities = 131/637 (20%), Positives = 277/637 (43%), Gaps = 66/637 (10%)
Query: 315 RSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIR-----------EIESELETRPSTEAQ 363
++ E ++Q+K+ L H + K+ L QK + E+E E+ R S E+
Sbjct: 478 KNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESA 537
Query: 364 TRQIEQLRAKLLAAETLCEELMDENEDMKKEL-RDLXXXXXXMQDNFREDQADEYSSLR- 421
RQ+E+ +A L + D D K+ L D+ ++D + +Q + S+ +
Sbjct: 538 LRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKV 597
Query: 422 RELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKE---- 477
+L++ + L L+ A +L + +AE K++ ++ +Q +N + E
Sbjct: 598 NQLQRQLDETNAL---LRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKL 654
Query: 478 -LEQE---VARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQE 533
LE+E + + E R + +E + G L + + + +++ L + QE
Sbjct: 655 KLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQE 714
Query: 534 DPAQLLRDLQD-SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
L ++ + ++ L+ ++ E+E A K DK + ++I + +S
Sbjct: 715 RFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHK-ATKARLADKNKIYESI---EEAKS 770
Query: 593 ETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRK 652
E + ++ K++ + K+K ++ L +K + DL + N L K
Sbjct: 771 EAM-KEMEKKLLEERTL---KQKVENLLLEAEKRC--SLLDCDLKQ----SQQKINELLK 820
Query: 653 TAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKL 712
+ ED +L L++++ + + R L+ N L ++T N K +++ E
Sbjct: 821 QKDVLNEDVRNLTLKIEQ---ETQKRCLT----QNDLKMQTQQVNTLKMSEKQLKQENNH 873
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L+E+ L ++ EL ++++ Q+KEL ++ + S T R
Sbjct: 874 LMEMKMN----LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVR-----ELK 924
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
+ EE+ K L E+ + +K+ ++ ERD E++L + + L +RS+ +++
Sbjct: 925 EECEEKTK-LGKELQQ-KKQELQDERDSLAAQLEITLTKADSEQL--ARSIAEEQYSDLE 980
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
++ ++ +E + + R K + E D E L + +L ++K +LN K
Sbjct: 981 KEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKE-ELNNKL--- 1036
Query: 893 LENELKEALAKIKELEMICQDEKSE-KKVRFTEATKK 928
+++E L+++K+ E+ K++ +K TE T K
Sbjct: 1037 --KDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLK 1071
Score = 57.2 bits (132), Expect = 6e-07
Identities = 142/755 (18%), Positives = 293/755 (38%), Gaps = 92/755 (12%)
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
+ ++ + K LE SN + L ++ K+ ++ K + +L+ +L+ +
Sbjct: 474 IQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKS 533
Query: 1118 MSDCMXXXXXXXXXXXXXXXXXXXXXX-QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXX 1176
+ + + D ++ D N L ++ D K+ +
Sbjct: 534 VESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQIS 593
Query: 1177 XXXXXXXCKRIEKQ---LSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIE---LTSEK 1230
+++++ L T D Q L + +R L + L + K
Sbjct: 594 TEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAK 653
Query: 1231 DELQARFIKTESKFITLEAEMRD------LKADYENKITSLESTIAAKDVHIKQLEDALR 1284
+L+ FI +S LE+E RD + D + +I LE + + + ++E R
Sbjct: 654 LKLEKEFINLQS---ALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKR 710
Query: 1285 QTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQ 1344
Q +++ + +E+ Q+E + K + +E A+
Sbjct: 711 QL-QERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAK 769
Query: 1345 LKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN 1404
++ + ++E E + LD DL+ ++K++ + KDV N
Sbjct: 770 SEA-MKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINEL--LKQKDVLN 826
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
+D TLK +EQ + +LK + ++ V L+ S EK +L
Sbjct: 827 EDVRNLTLK-----IEQETQKRCLTQNDLKMQTQQ-VNTLKMS---EK----------QL 867
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
+E + + + ++ +EK+ A+ ++KE A G++K LQ++L E KT+
Sbjct: 868 KQENNHLMEMKMNLEKQNAE-----LRKERQDADGQMKELQDQLEAEQYFSTLYKTQ--- 919
Query: 1525 SIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXX 1584
+ L+E C E+ +L L Q+++EL+ D RD L
Sbjct: 920 -VRELKEE-C-----EEKTKLGKELQQKKQELQ---DERDSL--------AAQLEITLTK 961
Query: 1585 XDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDEL 1644
D E++++ I++ K E+T+ + + ++ +
Sbjct: 962 ADSEQLAR--SIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEK----DATIASLEETN 1015
Query: 1645 KSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALL 1704
++L + V+ E++ L+ Q+ ++ +K+ + SA +I + E++ + L
Sbjct: 1016 RTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAA----AIKAQFEKQLLTERTLK 1071
Query: 1705 EQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVA 1764
Q V ++L E ++ K E V + +VR E ++R E L S R ++
Sbjct: 1072 TQAV----NKLAE--IMNRK---EPVKRGNDTDVRRKEKENRKLHME----LKSEREKL- 1117
Query: 1765 GLATRMELAWHKERDEQQRLLQETSTLARDLRQTL 1799
T+ + + KE +E Q + E S + +L+ TL
Sbjct: 1118 ---TQQMIKYQKELNEMQAQIAEESQIRIELQMTL 1149
Score = 57.2 bits (132), Expect = 6e-07
Identities = 85/413 (20%), Positives = 180/413 (43%), Gaps = 38/413 (9%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRC--ERVEKEKSDILLRRLANIDTANKYTTGRSSE 318
L D N K Y+ E + + + K+ ER K+K + LL A K + +
Sbjct: 755 LADKN-KIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLE------AEKRCSLLDCD 807
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKI-REIESELETRPSTEAQTRQIEQLR--AKLL 375
+ + QQK+NEL + L ++ ++LT KI +E + T+ + QT+Q+ L+ K L
Sbjct: 808 LKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQL 867
Query: 376 AAET--LCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSL-RRELEQTIK 429
E L E M+ +N +++KE +D +QD +Q +S+L + ++ + +
Sbjct: 868 KQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ--YFSTLYKTQVRELKE 925
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEV- 488
C + K+ ++K +L+ E+ +L + D Q I E + ++
Sbjct: 926 ECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIM 985
Query: 489 -ALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
L ++ +A + T + ++ + + + +LT D A L + ++
Sbjct: 986 KELEIKEMMARHKQELTEKDATIASLEE------TNRTLT-----SDVANLANEKEELNN 1034
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQVMTD-NIVTCDIHESETVTNSIQNKMIHA 606
+ D++EQL ++E + + +KQ++T+ + T +++ + N + +
Sbjct: 1035 KLKDVQEQLSRLKDEEISAAAIKAQ--FEKQLLTERTLKTQAVNKLAEIMNR-KEPVKRG 1091
Query: 607 ASTPSSKEKSDSPPLSID-KTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
T +++ ++ L ++ K+ E + Y N M A ++ R+E
Sbjct: 1092 NDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIE 1144
Score = 55.6 bits (128), Expect = 2e-06
Identities = 118/627 (18%), Positives = 261/627 (41%), Gaps = 42/627 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCE--RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQ- 323
+ ++ + LK +++ L+KR + ++ EK + L R+L + + + ++ + K Q
Sbjct: 567 RNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQA 626
Query: 324 ---QKVNELTTHNEDLRDEKKHLTQKIREIESE-LETRPSTEAQTRQ-------IEQLRA 372
+++ +L ++N DL+D+ L ++E E + + + E++ R I L+
Sbjct: 627 ESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQG 686
Query: 373 KLLAAETLCEE---LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
++ E + L+ + E K++L++ + N D + +++ LEQ
Sbjct: 687 RICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEA 746
Query: 430 NCRVLSFKLKKTERKADQLEQEKA----EHEKKLLEIVGGPDGMQRENRIKELEQEVARS 485
+ +L + + +E+ K+ E EKKLLE + EN + E E+ +
Sbjct: 747 EHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLE--ERTLKQKVENLLLEAEKRCSLL 804
Query: 486 TEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGG--SQEDPAQLLRDLQ 543
+ Q+++ E + N + + + + LT+ Q L+ +
Sbjct: 805 DCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSE 864
Query: 544 DSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNK 602
L++E + L E N E++ A ++ + + D + + T + K
Sbjct: 865 KQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELK 924
Query: 603 MIHAASTPSSKE-KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN 661
T KE + L ++ + Q L +A + + + +E++
Sbjct: 925 EECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKAD-SEQLARSIAEEQYSDLEKEK 983
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
L++K+M AR ++ A S+E N + + +L +L + +
Sbjct: 984 IMKELEIKEM--MARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQE 1041
Query: 722 TVLRRKVEELEQD--KEALKKQ-VKELTSKISSVTKTSAGSN--TTARRSLTTNSNKLAE 776
+ R K EE+ K +KQ + E T K +V K + N +R T+ + +
Sbjct: 1042 QLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEK 1101
Query: 777 ERVKV---LEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDL 833
E K+ L+ E +++ +++I+ +++ + A+ +A++ + +LD+ D L
Sbjct: 1102 ENRKLHMELKSEREKLTQQMIKYQKELNEMQAQ--IAEESQIRIELQMTLDSKDSDIEQL 1159
Query: 834 KRQLQV--IEQEASVLRAKTQSLEADN 858
+ QLQ I ++S + + EAD+
Sbjct: 1160 RSQLQALHIGLDSSSIGSGPGDAEADD 1186
Score = 48.8 bits (111), Expect = 2e-04
Identities = 142/723 (19%), Positives = 278/723 (38%), Gaps = 87/723 (12%)
Query: 827 DQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLN 886
++++ +++++L +E+ S + Q+ E +K ++ N +L+ K AK L + L +
Sbjct: 479 NEESQEIQKKLYTLEEHLS---NEMQAKEELEQKCKSVNTRLE--KTAKELEEEITLRKS 533
Query: 887 TKKTT-QLENELKEALAKIKELEMICQ-DEKSEKKVRF---TEATKKETDTLKSKQXXXX 941
+ QLE E +AL + K E + D +++KK + K + + LK +
Sbjct: 534 VESALRQLERE--KALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQ 591
Query: 942 XXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIG 1001
A L++ D A + K T+ + K ++ LE
Sbjct: 592 ISTEKVNQLQRQLDETNALLRTESDTAARLRK-----------TQAESSKQIQQLESNNR 640
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAK 1061
++ KN L TAK KLEKE ++S L + T+ + ++ +
Sbjct: 641 DLQD--KNCLLE----TAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEED 694
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
L+ K + A +E E L + L +E N E ++ LK +Q ++
Sbjct: 695 LKNGKILLAK----VELEKRQLQERFTDLEKEKSNMEID---MTYQLK---VIQQSLEQ- 743
Query: 1122 MXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXX 1181
+ Y I++ K++ +KE+ KK+ +
Sbjct: 744 ---------EEAEHKATKARLADKNKIYESIEEAKSEAMKEM---EKKLLEERTLKQKVE 791
Query: 1182 XXCKRIEKQLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTE 1241
EK+ S + Q VL R L++++ E T+
Sbjct: 792 NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQE----------TQ 841
Query: 1242 SKFITLEAEMRDLKADYE--NKITSLESTIAAKDVHIKQLEDAL-RQTTNDKYDEATSPV 1298
+ +T DLK + N + E + ++ H+ +++ L +Q + + +
Sbjct: 842 KRCLT----QNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADG 897
Query: 1299 EMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXX 1358
+M E++ + ++ K E+ E ++ K E+ Q K +L +
Sbjct: 898 QMKELQDQLEAEQYFSTLYKTQVRELK---EECEEKTKLGK-ELQQKKQELQDERDSLAA 953
Query: 1359 XXXXXXXXXXXSSYWENKAKELDTDLQSER--KKLD--RMRIAHDKDVKNKDAELATLKG 1414
+ A+E +DL+ E+ K+L+ M H +++ KDA +A+L+
Sbjct: 954 QLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEE 1013
Query: 1415 KLKILEQNSGAGAKRITELKQEYEETVKKL------EHSLALEKAEYEELTGKYELLEEE 1468
+ L + A EL + ++ ++L E S A KA++E+ L+ +
Sbjct: 1014 TNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQ 1073
Query: 1469 HVVTKARLTVEKEQAQG----ELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
V A + KE + ++ +KE E+K+ +EKL + + E EMQ
Sbjct: 1074 AVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQA 1133
Query: 1525 SIA 1527
IA
Sbjct: 1134 QIA 1136
Score = 43.2 bits (97), Expect = 0.010
Identities = 123/611 (20%), Positives = 235/611 (38%), Gaps = 64/611 (10%)
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEE----RVKVL 782
K LE D +LK Q+++L + + ++ N R+ TN+ E R++
Sbjct: 565 KKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKT 624
Query: 783 EDEIDEVRKKLIEKERDCERLHAELSLAQ-KKPKTLIKSRSLDASDQQN----VDLKRQL 837
+ E + ++L RD + + L A+ K K I +S S++++ ++ L
Sbjct: 625 QAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDL 684
Query: 838 Q--VIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNT--KKTTQL 893
Q + E + K + + EK Q + + L K ++ D L + Q
Sbjct: 685 QGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQE 744
Query: 894 ENELKEALAKIKELEMICQDEKSEKKVRFTEATKK--ETDTLKSK-QXXXXXXXXXXXXX 950
E E K A++ + I + + K E KK E TLK K +
Sbjct: 745 EAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLL 804
Query: 951 XXXXXXXQATLKSL--KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK 1008
Q + L + D + K T K L + DL+ + ++ +
Sbjct: 805 DCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQ--NDLKMQTQQVNTLKM 862
Query: 1009 NAGLSGKE----MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQ----------TEIAK 1054
+ +E M K LEK+ E+R + D + +++L+ T++ +
Sbjct: 863 SEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRE 922
Query: 1055 LK-DVNAKLEGDKDVFANKYKALENENSNLSNQCK-TLT----EEMKN--REAQINKLSA 1106
LK + K + K++ K + L++E +L+ Q + TLT E++ E Q + L
Sbjct: 923 LKEECEEKTKLGKEL-QQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEK 981
Query: 1107 D-LKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGD 1165
+ + ++ M+ V N ++ N LK+V +
Sbjct: 982 EKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQE 1041
Query: 1166 KTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXX--XXXXXXXXXQAVVLAN------ 1217
+ ++ D + EKQL T + T + V N
Sbjct: 1042 QLSRLKDEEISAAAIKA---QFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRR 1098
Query: 1218 ---THRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKI-TSLESTIAAKD 1273
+R+L +EL SE+++L + IK + + ++A++ + E++I L+ T+ +KD
Sbjct: 1099 KEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAE-----ESQIRIELQMTLDSKD 1153
Query: 1274 VHIKQLEDALR 1284
I+QL L+
Sbjct: 1154 SDIEQLRSQLQ 1164
>X95654-1|CAA64956.1| 976|Homo sapiens polypeptide of 976 aa
protein.
Length = 976
Score = 65.7 bits (153), Expect = 2e-09
Identities = 123/604 (20%), Positives = 252/604 (41%), Gaps = 37/604 (6%)
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETL 380
L + ++L E ++ K ++R+ ES+L E R EAQ + I++L+
Sbjct: 102 LSRVFSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLK 161
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
EE + EN+D+ KE +++ A++ E E+T + L+ ++K
Sbjct: 162 LEEGIQENKDLIKENNATRHLCNLLKETCAR-SAEKTKKYEYEREETRQVYMDLNNNIEK 220
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN 500
+L + +AE+ + + D + ++ +E ++E+ + L ++ E
Sbjct: 221 MITAHGEL-RVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKE 279
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAE 560
+K L + + KV++ +E +L+ S+E++ L ++L + +
Sbjct: 280 NKM----KDLTFLLEESRDKVNQ-------LEEKTKLQSENLKQSIEKQHHLTKELEDIK 328
Query: 561 EETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
D Q+ T I C + E + NK A S ++ ++
Sbjct: 329 VSLQRSVSTQKALEEDLQIATKTI--CQLTEEKETQMEESNKARAAHSFVVTEFETTVCS 386
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
L TE+ + + L I L+K ++ +EE + L K++ + + L
Sbjct: 387 LEELLRTEQQRLEKNEDQLKIL----TMELQKKSSELEEMTK--LTNNKEVELEELKKVL 440
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKL--LLELNEQEATVLRRKVEELEQDKEAL 738
K ++ N EK +E E +L LL+ E+E L ++ + ++
Sbjct: 441 -----GEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
Query: 739 KKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKER 798
K+VK+L +++ + K T+ L+ + +L +E + E+ ++ + ++
Sbjct: 496 SKEVKDLKTELEN-EKLKNTELTSHCNKLSLENKELTQE-TSDMTLELKNQQEDINNNKK 553
Query: 799 DCERLHAELSLAQKKPKTLIKSRSL--DASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
ER+ ++ Q+ L + Q+ ++K +L E+ + LR + ++
Sbjct: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
Query: 857 DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKS 916
E+LQ ENK L+ A+S K L++ K +LE EL+ A K E+ Q E
Sbjct: 614 YIEELQQENKALKKKGTAES----KQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIE 669
Query: 917 EKKV 920
+KK+
Sbjct: 670 DKKI 673
Score = 62.1 bits (144), Expect = 2e-08
Identities = 85/406 (20%), Positives = 170/406 (41%), Gaps = 29/406 (7%)
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARR-----SLTTNSNKLAEERV 779
++++ + E+ L Q+ E +K+ +T S + L + + K + E+
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 780 KVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
L E+++++ L + L +L +A K L + + + V
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKE 899
E E +V + + L + ++L+ +L++L +S + L+ TK T E EL+E
Sbjct: 378 TEFETTVCSLE-ELLRTEQQRLEKNEDQLKILTMELQKKSSE-LEEMTKLTNNKEVELEE 435
Query: 900 ALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQA 959
+ E E + + K +K+ E E + + Q Q
Sbjct: 436 LKKVLGEKETLLYENKQFEKIA-EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
Query: 960 TLKSLKDDAQKSFKPRIPKKPTDLTT---KLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
K +KD + ++ K T+LT+ KL L+ ++L E +M + +KN ++
Sbjct: 495 YSKEVKDLKTELENEKL--KNTELTSHCNKLSLEN--KELTQETSDMTLELKN---QQED 547
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD-VNAKLEGDKDVFANKYKA 1075
+ K E+ + + L + +++ NE ++ E+ + +D V KL+ ++ N K
Sbjct: 548 INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
Query: 1076 LENENS---NLSNQCKTL----TEEMKNR---EAQINKLSADLKNA 1111
+EN+N L + K L T E K E ++NKL +L++A
Sbjct: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESA 653
Score = 60.5 bits (140), Expect = 6e-08
Identities = 138/750 (18%), Positives = 296/750 (39%), Gaps = 57/750 (7%)
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L ++ E++++ K + + ++++ SK+ K A + L + K++ + + ++
Sbjct: 109 LYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRK-AIQELQFGNEKVSLKLEEGIQ 167
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ D +++ + C L + + +K K R + + Q +DL ++ +
Sbjct: 168 ENKDLIKENNATRHL-CNLLKETCARSAEKTKKYEYER--EETRQVYMDLNNNIEKMITA 224
Query: 844 ASVLRAKTQSLEADNE-KLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALA 902
LR + ++ + KL+ + +K+Q L+ K ++ K+ + L ++ E
Sbjct: 225 HGELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK----KEINDKEKQVSLLLIQITEKEN 280
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLK 962
K+K+L + ++ + +K + E TK +++ LK +T K
Sbjct: 281 KMKDLTFLLEESR-DKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
Query: 963 SLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK 1022
+L++D Q I K T+ + +M E + +VV + T
Sbjct: 340 ALEEDLQ------IATKTICQLTEEKETQMEESNKARAAHSFVVTEFE-------TTVCS 386
Query: 1023 LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSN 1082
LE+ + + +L KN+ + LQ + ++L+++ KL +K+V + K + E
Sbjct: 387 LEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT-KLTNNKEVELEELKKVLGEKET 445
Query: 1083 L---SNQCKTLTEEMKNREAQ-INKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXX 1138
L + Q + + EE+K E + I L A K L+ ++
Sbjct: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLT--AITTSEQYYSKEVKDLK 503
Query: 1139 XXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRV 1198
++ N T++ NKL E + T++ D +L +++ +
Sbjct: 504 TELENEKLKN-TELTSHCNKLSLENKELTQETSDMTL--------------ELKNQQEDI 548
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADY 1258
Q L T +L EL ++EL+ + + + K E +L+
Sbjct: 549 NNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV 608
Query: 1259 ENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQ 1318
ENK +E + ++ +K+ A + N Y+ + +E+ E+ Q
Sbjct: 609 ENKNKYIEE-LQQENKALKKKGTAESKQLN-VYEIKVNKLEL-ELESAKQKFGEITDTYQ 665
Query: 1319 DELNNAKIKLEKTEAESSAAKL---EMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWEN 1375
E+ + KI E E AK+ E +L+ ++ K ++
Sbjct: 666 KEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDK--RCQHKIAEMVALMEKHKHQYDK 723
Query: 1376 KAKELDTDL---QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITE 1432
+E D++L +S+ ++ +R + + ++ N AEL ++K +L+I + + E
Sbjct: 724 IIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
Query: 1433 LKQEYEETVKKLEHSLALEKAE-YEELTGK 1461
+E K + LE E Y +L K
Sbjct: 784 NTATLKEKKDKKTQTFLLETPEIYWKLDSK 813
Score = 55.6 bits (128), Expect = 2e-06
Identities = 118/696 (16%), Positives = 256/696 (36%), Gaps = 46/696 (6%)
Query: 840 IEQEASVLRAKTQSLEADN---EKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE 896
+ Q+ S L+ + +EA ++LQ N+K+ L K + ++ +K L T L N
Sbjct: 127 LRQKESKLQENRKIIEAQRKAIQELQFGNEKVSL-KLEEGIQENKDLIKENNATRHLCNL 185
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXX 956
LKE A+ E + E+ E + + + + +
Sbjct: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAHGELRVQAENSRLEMHFKLKE 245
Query: 957 XQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKE 1016
++ L+ + +K + +K L L + + E ++ ++ +++ + +
Sbjct: 246 DYEKIQHLEQEYKKEINDK--EKQVSL-----LLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 1017 MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKAL 1076
+ KTKL+ E ++ + K T E ++ + + LE D + L
Sbjct: 299 LEEKTKLQSE--NLKQSIEKQH-HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQL 355
Query: 1077 ENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXX 1136
E + E K R A ++ SL+ +
Sbjct: 356 TEEKET------QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILT 409
Query: 1137 XXXXXXXXQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKD 1196
+++ TK+ +K L+E+ K +G+ K E+ T ++
Sbjct: 410 MELQKKSSELEEMTKLTNNKEVELEEL---KKVLGEKETLLYENKQFEKIAEELKGTEQE 466
Query: 1197 RV---TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIK-TE--SKFITLEAE 1250
+ Q + + + S E+ K EL+ +K TE S L E
Sbjct: 467 LIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLE 526
Query: 1251 MRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXX 1310
++L + + L++ + + KQ E L+Q N + E ++R
Sbjct: 527 NKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETET-------QLRNELEYV 579
Query: 1311 XXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXS 1370
+DE+ K KL+K+E + + ++ + +L+
Sbjct: 580 REELKQKRDEV---KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQL 636
Query: 1371 SYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI 1430
+ +E K +L+ +L+S ++K + + K++++K L +++ + + K
Sbjct: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQ 696
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEEL-------TGKYELLEEEHVVTKARLTVEKEQA 1483
E+ + + + ++ + K +Y+++ G Y+ E+E +A L +E
Sbjct: 697 KEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL 756
Query: 1484 QGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK 1519
+ ELL V+K+L E + L+ + +A +K
Sbjct: 757 KAELLSVKKQLEIEREEKEKLKREAKENTATLKEKK 792
Score = 54.4 bits (125), Expect = 4e-06
Identities = 120/585 (20%), Positives = 247/585 (42%), Gaps = 61/585 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+KE ++I+ L+QE +K EK+ S +L++ + T K+ Q
Sbjct: 243 LKEDYEKIQHLEQEY---KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQL 299
Query: 326 VNELTTHNEDLR---DEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCE 382
+ +E+L+ +++ HLT+++ +I+ L+ ST+ + Q +A +T+C
Sbjct: 300 EEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQ-----IATKTIC- 353
Query: 383 ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKN---CRVLSFKLK 439
+L +E E +E + F LR E ++ KN ++L+ +L+
Sbjct: 354 QLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQ 413
Query: 440 KTERKADQ---LEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL 496
K + ++ L K ++L +++G + + EN+ E E + TE L L
Sbjct: 414 KKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQEL---IGL 470
Query: 497 AEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQL 556
+A K + +++ +++T S++ ++ ++DL+ LE E+L
Sbjct: 471 LQAREK------------EVHDLEIQLTAITT--SEQYYSKEVKDLKTELE-----NEKL 511
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDI-HESETVTNSIQNKMIHAASTPSSKEK 615
+N E T++C +++ Q +D +T ++ ++ E + N+ + + + +E
Sbjct: 512 KNT-ELTSHCNKLSLENKELTQETSD--MTLELKNQQEDINNNKKQEERMLKQIENLQET 568
Query: 616 SDSPPLSIDKTTEETQFHFDLPYLSI-FNHMAANNLRKTAARVEEDNESLLLQLKKMATK 674
++ EE + D + + NNLRK + E L + K + K
Sbjct: 569 ETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKK 628
Query: 675 --ARSRKLSPTP-PANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEEL 731
A S++L+ NKL +E ++ +++ E K + + E +L EE+
Sbjct: 629 GTAESKQLNVYEIKVNKLELEL--ESAKQKFGEITDTYQKEIEDKKISEENLL----EEV 682
Query: 732 EQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRK 791
E+ K + VK L +I + +K+ EER + E+ +
Sbjct: 683 EKAKVIADEAVK-LQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEER----DSELGLYKS 737
Query: 792 KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQ 836
K E+E+ R E+ L+ K + L + L+ ++ LKR+
Sbjct: 738 K--EQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
Score = 54.0 bits (124), Expect = 5e-06
Identities = 92/458 (20%), Positives = 177/458 (38%), Gaps = 35/458 (7%)
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-KLSIETANDNDEKETDEADPAEM 710
K + E + LQ + +A+ + + N K+S++ E + +
Sbjct: 120 KVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNAT 179
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ L L ++ K ++ E ++E ++ +L + I + A S
Sbjct: 180 RHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAHGELRVQAENSRLEM 239
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK--TLIKSRSLDASDQ 828
KL E+ K+ E E +K++ +KE+ L +++ + K K T + S D +Q
Sbjct: 240 HFKLKEDYEKIQHLE-QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQ 298
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
K Q + ++Q T+ LE LQ + L+ + + L +
Sbjct: 299 LEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEE 358
Query: 889 KTTQLENELKEALAK---IKELEM-ICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXX 944
K TQ+E K A + E E +C E+ + + + +K D LK
Sbjct: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ--QRLEKNEDQLK--------IL 408
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
L + K+ + K + +K T L Q +K+ E+L+ E+
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEG 1064
GL + A+ K +++ + ++ ++ ++ E L+TE+ K N +L
Sbjct: 469 ------GL----LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS 518
Query: 1065 DKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQIN 1102
NK L EN L+ + +T E+KN++ IN
Sbjct: 519 H----CNK---LSLENKELTQETSDMTLELKNQQEDIN 549
Score = 50.4 bits (115), Expect = 6e-05
Identities = 116/585 (19%), Positives = 232/585 (39%), Gaps = 65/585 (11%)
Query: 345 QKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXX 404
+KI+ +E E + + +Q+ L ++ E ++L E+ + ++ L
Sbjct: 248 EKIQHLEQEY--KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKL 305
Query: 405 MQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVG 464
+N ++ ++ L +ELE IK +S + + +KA LE++ K + ++
Sbjct: 306 QSENLKQS-IEKQHHLTKELED-IK----VSLQRSVSTQKA--LEEDLQIATKTICQLTE 357
Query: 465 GPDG-MQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ M+ N+ + V E + EL + N +K+ E K S
Sbjct: 358 EKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSS 417
Query: 524 -----SSLTRGGSQE--DPAQLLRDLQDSLEREAD---LREQLRNAEEETANCKQVNPPT 573
+ LT E + ++L + + L + E+L+ E+E Q
Sbjct: 418 ELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKE 477
Query: 574 FLDKQVMTDNIVTCDIHESETVTN---SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
D ++ I T + + S+ V + ++N+ + S K + + T +
Sbjct: 478 VHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDM 537
Query: 631 QFHFDLPYLSIFNHMAAN--------NLRKTAARVEEDNESLLLQLKKMATKARSRKLSP 682
I N+ NL++T ++ + E + +LK+ + + +
Sbjct: 538 TLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKS 597
Query: 683 TPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQV 742
N L + N N E + + +K ++ V KV +LE + E+ K++
Sbjct: 598 EENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKF 657
Query: 743 KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE-ERVKVLEDEIDEVRKKLIEKERDCE 801
E+T + + N L E E+ KV+ DE +++K++ ++ C+
Sbjct: 658 GEITDTYQKEIEDKK----------ISEENLLEEVEKAKVIADEAVKLQKEI---DKRCQ 704
Query: 802 RLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL 861
AE+ +K K + ++ D + K + EQE S LRA SLE +
Sbjct: 705 HKIAEMVALMEKHKHQY-DKIIEERDSELGLYKSK----EQEQSSLRA---SLE-----I 751
Query: 862 QTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
+ N K +LL S++ K L++ ++ +L+ E KE A +KE
Sbjct: 752 ELSNLKAELL----SVK--KQLEIEREEKEKLKREAKENTATLKE 790
>BC109126-1|AAI09127.1| 872|Homo sapiens chromosome 10 open reading
frame 80 protein.
Length = 872
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/330 (24%), Positives = 145/330 (43%), Gaps = 24/330 (7%)
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
LS DK+ E+ F + L + +N ++ A+ E N +++ K+AT + +
Sbjct: 30 LSGDKSLEK--FRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQD 87
Query: 681 SPTPPAN-KLSIE-------TANDNDEK--ETDEADPAEMKLLLELNEQEATVL---RRK 727
T A+ K IE +A D ++K ET A E+ L +L EQ + +
Sbjct: 88 DQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSN 147
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
+ +L + KE + K+ +L S++ + ++ A TT ++ T S + AE + + EI
Sbjct: 148 IRDLLRFKEEVTKERDQLLSEVVKLRESLA--QTTEQQQETERSKEEAEHAISQFQQEIQ 205
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
+ + + + R E+L EL Q + + + A Q K +LQ +EQ+
Sbjct: 206 QRQNEASREFRKKEKLEKELKQIQADMDS--RQTEIKALQQYVQKSKEELQKLEQQLKEQ 263
Query: 848 RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL---ENELKEALAKI 904
+ + + E+ Q N KLQ SL ++ N +K +L E E+ + I
Sbjct: 264 KILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDI 323
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLK 934
+L I E+ KK+ TE K E + K
Sbjct: 324 GKLNKI--REQIHKKLHHTEDQKAEVEQHK 351
Score = 62.1 bits (144), Expect = 2e-08
Identities = 76/420 (18%), Positives = 173/420 (41%), Gaps = 17/420 (4%)
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
E+ E E+ +L+ LA+ S ++ + ++ + E
Sbjct: 156 EEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREF 215
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
+K +++ +K++K A++ + + ++K L+Q + + +L+Q+ +E K L
Sbjct: 216 RKKEKL----EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQ-KILNERA 270
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA---LGEIKTLQ 1505
A E +++ K + E+H + +L+ E +Q EL ++E+ +G++ ++
Sbjct: 271 AKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIR 330
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDV 1565
E++ + +K E++ +L+ ++ G EVE ++ A LD++ + RD+
Sbjct: 331 EQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMD--ELLRERDI 388
Query: 1566 LEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAE 1625
L + +E+ +R I EK R
Sbjct: 389 LNKNMLKAVNATQKQTDLVKLHEQA---KRNLEGEIQNYKDEAQKQRKIIFHLEKERDRY 445
Query: 1626 ITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH 1685
I + + M D +K Q+ +R++ + L+ Q+++ E D++
Sbjct: 446 INQASDLTQKVLMNMED-IKVRETQIFDYRKKIAESEIKLK-QQQNLYEAVRSDRNL-YS 502
Query: 1686 RNSISSTDE-EEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
+N + + DE + + K+ ++ QV L++++ KL+ E + E AE+Q
Sbjct: 503 KNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQ 562
Score = 59.3 bits (137), Expect = 1e-07
Identities = 115/614 (18%), Positives = 250/614 (40%), Gaps = 42/614 (6%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
EY+ +K+ D ++ + + ++I++ A + TA K + + + L++++
Sbjct: 42 EYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNS-AKVATALKLSQDDQTTIASLKKEIE 100
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
+ + D+++ + I ++ E+ T+ +EQ + + +L+
Sbjct: 101 KAWKMVDSAYDKEQKAKETILALKEEIVNL------TKLVEQGSGLSMDQHSNIRDLLRF 154
Query: 388 NEDMKKELRDLXXXXXXMQDNFRE--DQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
E++ KE L ++++ + +Q E + E E I + ++++ + +A
Sbjct: 155 KEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQ---EIQQRQNEA 211
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
+ ++K + EK+L +I D Q E IK L+Q V +S E +L+++L E
Sbjct: 212 SREFRKKEKLEKELKQIQADMDSRQTE--IKALQQYVQKSKEELQKLEQQLKEQKILNER 269
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ L + Q K+ + + E +Q + Q +LE +A E++ +
Sbjct: 270 AAKELEQF-QMRNAKLQQENEQHSLVCEQLSQ--ENQQKALELKAK-EEEVHQMRLDIGK 325
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDK 625
++ D + H+ ET+ N I +SK++++ ++D+
Sbjct: 326 LNKIREQIHKKLHHTEDQKAEVEQHK-ETLKNQIVGL---EREVEASKKQAELDRKAMDE 381
Query: 626 TTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPP 685
E ++ +L K + + + E + K A K R
Sbjct: 382 LLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKE 441
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKEL 745
++ I A+D +K + +++ E + R+K+ E E KQ + L
Sbjct: 442 RDRY-INQASDLTQKVLMNMED------IKVRETQIFDYRKKIAE----SEIKLKQQQNL 490
Query: 746 TSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHA 805
+ S + + A+ +T KL K++ ++DE+++ + KE +LH
Sbjct: 491 YEAVRSDRNLYSKNLVEAQDEITDMKRKL-----KIMIHQVDELKEDISAKESALVKLHL 545
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +K+ +TL L QQ ++ K ++ +QEA + EAD E+L+ +
Sbjct: 546 EQQRIEKEKETL--KAELQKLRQQALETKHFIE--KQEAEERKLLRIIAEADGERLRQKK 601
Query: 866 KKLQLLKNAKSLRS 879
+ Q++ L S
Sbjct: 602 ELDQVISERDILGS 615
Score = 57.6 bits (133), Expect = 4e-07
Identities = 137/763 (17%), Positives = 288/763 (37%), Gaps = 51/763 (6%)
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV----IEQEASVLRAK 850
E ERD + + ELS + K I+ L A +++ D +++L + E V AK
Sbjct: 18 EMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAK 77
Query: 851 TQS---LEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT-QLENELKEALAKIKE 906
+ L D++ KK ++ K K + S + K+T L+ E+ +++
Sbjct: 78 VATALKLSQDDQTTIASLKK-EIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQ 136
Query: 907 LEMICQDEKSEKK--VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
+ D+ S + +RF E KE D L S+ + +
Sbjct: 137 GSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHA 196
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE 1024
Q+ + R + + K +L+K ++ ++ ++ +K ++ K+K
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKAL----QQYVQKSK-- 250
Query: 1025 KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
+E+ ++ +L + + NE R E+ + + NAKL+ + N+ +L E +
Sbjct: 251 EELQKLEQQLK--EQKILNE--RAAKELEQFQMRNAKLQQE-----NEQHSLVCEQLSQE 301
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
NQ K L E+K +E +++++ D+ ++ + +
Sbjct: 302 NQQKAL--ELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIV 359
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
++ + + + +L ++ D+ + D + + L ++
Sbjct: 360 GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI-TLEAEMRDLKADYENKIT 1263
A R++ L E+D R+I S + M D+K E +I
Sbjct: 420 EIQNYKDE---AQKQRKIIFHLEKERD----RYINQASDLTQKVLMNMEDIKV-RETQIF 471
Query: 1264 SLESTIAAKDVHIKQLEDALRQTTNDK--YDE--ATSPVEMVEMRXXXXXXXXXXXXXQD 1319
IA ++ +KQ ++ +D+ Y + + E+ +M+ ++
Sbjct: 472 DYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKE 531
Query: 1320 ELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE 1379
+++ + L K E + E LK++L KL E
Sbjct: 532 DISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAE 591
Query: 1380 LDTDLQSERKKLDRMRIAHD---KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQE 1436
D + ++K+LD++ D + ++ ELA L K+KI + G + + ++
Sbjct: 592 ADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED 651
Query: 1437 ---YEETVKKLEHS---LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGEL-LH 1489
+KKL LA A EEL ++ ++ E + + R +E+ + L +H
Sbjct: 652 MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVH 711
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQER 1532
++L + L +K+ T ++ E+ LQE+
Sbjct: 712 RWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEK 754
Score = 47.2 bits (107), Expect = 6e-04
Identities = 126/664 (18%), Positives = 266/664 (40%), Gaps = 48/664 (7%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKL 322
+ ++Q +I+ + E ++ E++EKE I + R I +Y E+ KL
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKL 256
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA--ETL 380
+Q++ E NE E + + +++ E E Q Q Q +A L A E +
Sbjct: 257 EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
Query: 381 CEELMDEN------EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +D E + K+L ++ + +E ++ L RE+E + K +
Sbjct: 317 HQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH-KETLKNQIVGLEREVEASKKQAELD 375
Query: 435 SFKLKKTERKADQLEQE--KAEHE-KKLLEIVGGPDGMQR--ENRIKELEQEVARSTEVA 489
+ + R+ D L + KA + +K ++V + +R E I+ + E + ++
Sbjct: 376 RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKII 435
Query: 490 LRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSL----TRGGSQEDPAQLLRDLQDS 545
L++E ++ + ++ E +KV + + + E + ++L ++
Sbjct: 436 FHLEKERDRYINQASDLTQKVLM--NMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEA 493
Query: 546 LEREADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
+ + +L + L A++E + K+ + ++I ES V ++ + I
Sbjct: 494 VRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDI---SAKESALVKLHLEQQRI 550
Query: 605 HAASTPSSKEKSDSPPLSID-KTTEETQFHFDLPYLSIFNHMAANNLR--KTAARVEEDN 661
E +++ K E Q + L I LR K +V +
Sbjct: 551 EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISER 610
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLELNEQE 720
+ L QL + R+ +L+ K+ N + + + ++L ++ +E
Sbjct: 611 DILGSQLVR-----RNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRRE 665
Query: 721 ATVLRRK---VEELEQDKEALKKQV-KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
+L R VEEL Q+ +++++ KE T + + N R L + E
Sbjct: 666 KGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYE 725
Query: 777 --ERVKVLEDEIDEVRKKLIEKE---RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
+++ L+ + ++++EKE ++ E+L+ EL + + L +
Sbjct: 726 LIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLH 785
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT 891
D K+QL+V+ E ++ +++ + + EKL E LQ LK + K K T
Sbjct: 786 DKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNE---LQNLKKKYLAQKRKEQLQKNKDTA 842
Query: 892 QLEN 895
++N
Sbjct: 843 PMDN 846
Score = 45.6 bits (103), Expect = 0.002
Identities = 60/348 (17%), Positives = 143/348 (41%), Gaps = 12/348 (3%)
Query: 162 NDSLAER-VRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVN 220
++ L ER + +LK N+ +K+ + K E+ +K + + YKDE + +
Sbjct: 380 DELLRERDILNKNMLKAVNATQKQTDLVKLHEQ---AKRNLEGEIQNYKDEAQKQRKIIF 436
Query: 221 FLMQVKNS--RNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQ 278
L + ++ +++L V + +K+ Q+ E ++
Sbjct: 437 HLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRS 496
Query: 279 EVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+ ++ K + E +D+ L + +D + + + S ++KL + + E
Sbjct: 497 DRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKET 556
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELMDENEDMKKE 394
L+ E + L Q+ E + +E + + E + R I + + L + ++++ E + + +
Sbjct: 557 LKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQ 616
Query: 395 LRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAE 454
L + + + Q+ + + Q +++ R+L ++KK R+ L + A
Sbjct: 617 LVRRNDELALLYEKIKIQQS-VLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMAN 675
Query: 455 HEKKLLEIVGGPDGMQRE-NRIKELEQEVARSTEVALRLQRELAEANS 501
E+ E + +E R + LE+E+ V + E ++ N+
Sbjct: 676 VEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNA 723
Score = 42.7 bits (96), Expect = 0.013
Identities = 90/378 (23%), Positives = 163/378 (43%), Gaps = 67/378 (17%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR-LANIDTANKY-TTGRSSEV 319
V+ + + ++QI GL++EV+ +K+ E K ++L R + N + T + +++
Sbjct: 347 VEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDL 406
Query: 320 LKLQ------------------QKVNELTTHNEDLRD----EKKHLTQKIREIESELETR 357
+KL QK ++ H E RD + LTQK+ +++ R
Sbjct: 407 VKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVR 466
Query: 358 PSTEAQTR-QIEQLRAKLLAAETLCE--------------ELMDENEDMKKELRDLXXXX 402
+ R +I + KL + L E E DE DMK++L+ +
Sbjct: 467 ETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIM---- 522
Query: 403 XXMQDNFRED-QADEYSSLRRELEQ--TIKNCRVLSFKLKKTERKADQ----LEQEKAEH 455
D +ED A E + ++ LEQ K L +L+K ++A + +E+++AE
Sbjct: 523 IHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAE- 581
Query: 456 EKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ 515
E+KLL I+ DG +R + KEL+Q ++ +R++ S+ N L +
Sbjct: 582 ERKLLRIIAEADG-ERLRQKKELDQVIS---------ERDI--LGSQLVRRNDELALL-- 627
Query: 516 PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFL 575
E +K+ +S L +G SQ + Q L D++ LR + AN +++ F
Sbjct: 628 YEKIKIQQSVLNKGESQYN--QRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFH 685
Query: 576 DKQVMTDNIVTCDIHESE 593
++ + C E E
Sbjct: 686 MQRELLKERTRCRALEEE 703
>BC043398-1|AAH43398.1| 805|Homo sapiens CEP290 protein protein.
Length = 805
Score = 65.3 bits (152), Expect = 2e-09
Identities = 148/729 (20%), Positives = 315/729 (43%), Gaps = 80/729 (10%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
+ S +K ++E +EV+ + + E + +++ ++ A + GR + L
Sbjct: 54 ITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFL 113
Query: 321 KLQ--QKVNELTTHNEDLRDEKKHLTQKIREIESELETR-PSTEAQTRQIEQLRAKLLAA 377
+ + Q +L + +L D +K L +K +++ +L R E + ++ + +L
Sbjct: 114 RNEICQLEKQLEQKDRELEDMEKEL-EKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
Query: 378 -ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSF 436
E LC++++D + + + L +D+ D + S EL Q + + L+
Sbjct: 173 NEQLCQDIIDYQKQIDSQKETLLSRRG--EDS---DYRSQLSKKNYELIQYLDEIQTLTE 227
Query: 437 KLKKTERKADQLEQEKAEHEKKLLEIVGGPDGM-----QRENRIKELEQEVARSTEVALR 491
+K E + ++ + E +++ ++ + M Q +N I +L++E + L+
Sbjct: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKE---NDHYQLQ 284
Query: 492 LQRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER-- 548
+Q SK +P ++ V + E K+ SS + + Q+L +L++ L+
Sbjct: 285 VQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSS--KDDEIIEYQQMLHNLREKLKNAQ 342
Query: 549 -EADLREQL---RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
+AD + + +E + K + + M N TC I E + N +Q
Sbjct: 343 LDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN--TCII---EDLKNELQRNKG 397
Query: 605 HAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDN--- 661
+ + + K S + + T+E + +L L + R+++
Sbjct: 398 ASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADA--REKDKELVEALKRLKDYESGV 455
Query: 662 ---ESLLLQLK--KMATKARSRKLSP-TPPANKLSIETANDNDEKET-DEADPAEMKLLL 714
E ++++K K K R R++ T NKL ++ ++ DE E E E K ++
Sbjct: 456 YGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMI 515
Query: 715 ELNE-------------QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNT 761
+L E E +L +++E LE+++ LKK+++++ + + TS T
Sbjct: 516 DLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG--LT 573
Query: 762 TARRSLTTN---SNKLAEERVKVLE-DEIDEVRKK-------LIEKERDCERLHAELSLA 810
T +LT N ++++E ++ +L + E + K LIEKERD ER ++
Sbjct: 574 TEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKF 633
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL--QTENKKL 868
Q K K L++ ++ ++ + ++ ++++ V +T + E+L E+K
Sbjct: 634 QNKLKELVEENK--QLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNA 691
Query: 869 QLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKK 928
+ + +A SL +D T + +L EL+E ++ + + Q K+ K+ E K
Sbjct: 692 EGIFDA-SLHLKAQVDQLTGRNEELRQELRE--SRKEAINYSQQLAKANLKIDHLE---K 745
Query: 929 ETDTLKSKQ 937
ET L+ +
Sbjct: 746 ETSLLRQSE 754
Score = 43.6 bits (98), Expect = 0.007
Identities = 101/496 (20%), Positives = 199/496 (40%), Gaps = 32/496 (6%)
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L L K E ++L+ EK E+ L I M+ + LE EV ++ E + +
Sbjct: 28 LLISLSKVE--VNELKSEKQENVIHLFRITQSLMKMKAQEVELALE-EVEKAGEEQAKFE 84
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ-EDPAQLLRDLQDSLEREADL 552
+L K + + R+ + + Q E + L D++ LE+E +
Sbjct: 85 NQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKV 144
Query: 553 REQ--LRNAEEETANCKQVNPPTFLDKQVMTDNIVTC-DIHESETVTNSIQNKMIHAAST 609
EQ LRN E E N K +K++ N C DI + + +S + ++
Sbjct: 145 NEQLALRNEEAENENSKLRRE----NKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRG- 199
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
E SD K E Q+ ++ L+ N ++ +EE + +++
Sbjct: 200 ----EDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEES----VQEME 251
Query: 670 KMATKARSRKLSPTPPANKL-SIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKV 728
KM + K N + ++ ND+ + + E +K E ++ + KV
Sbjct: 252 KMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKV 310
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER---VKVLEDE 785
EE + + ++ E + ++ + + A +S + +ER +K+L ++
Sbjct: 311 EEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQ 370
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEAS 845
+++ K++ + E L EL K TL S+ Q +D+ ++ + E E +
Sbjct: 371 VEQYTKEMEKNTCIIEDLKNELQ-RNKGASTL--SQQTHMKIQSTLDILKE-KTKEAERT 426
Query: 846 VLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDL-NTKKTTQLENELKEALAK- 903
A+ + E D E ++ K+L+ ++ D +++ N K ++ + E L K
Sbjct: 427 AELAEADAREKDKELVEA-LKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKE 485
Query: 904 IKELEMICQDEKSEKK 919
I +LE+ D E +
Sbjct: 486 INKLELKISDFLDENE 501
Score = 42.7 bits (96), Expect = 0.013
Identities = 86/420 (20%), Positives = 175/420 (41%), Gaps = 46/420 (10%)
Query: 700 KETDEADPAEMKLLLELNEQEATVLRR-KVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
KE + DP ++ EL + L + +V EL+ +K+ + V L S+ K A
Sbjct: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQ---ENVIHLFRITQSLMKMKAQ 64
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLI 818
A + K EE+ K E+++ + K+++ E + E A+ S + + L
Sbjct: 65 EVELALEEV----EKAGEEQAK-FENQL---KTKVMKLENELEM--AQQSAGGRDTRFLR 114
Query: 819 KS-----RSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKN 873
+ L+ D++ D++++L+ ++ L + + E +N KL+ ENK+L+ K
Sbjct: 115 NEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLK--KK 172
Query: 874 AKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTL 933
+ L D +D + +Q E L + E S+ + + ++ + L
Sbjct: 173 NEQLCQD-IIDYQKQIDSQKETLLSR------------RGEDSDYRSQLSKKNYELIQYL 219
Query: 934 KSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMV 993
Q + +++ ++ + + + TD QLKK
Sbjct: 220 DEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVID-QLKKEN 278
Query: 994 EDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIA 1053
+ + ++ E+ ++K+ + ++ + +++E + LS D E + L
Sbjct: 279 DHYQLQVQELTDLLKSK--NEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLRE 336
Query: 1054 KLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINK---LSADLKN 1110
KLK NA+L+ DK + AL+ +Q K LTE+++ ++ K + DLKN
Sbjct: 337 KLK--NAQLDADK----SNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKN 390
>BC036225-1|AAH36225.1| 872|Homo sapiens chromosome 10 open reading
frame 80 protein.
Length = 872
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/330 (24%), Positives = 145/330 (43%), Gaps = 24/330 (7%)
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
LS DK+ E+ F + L + +N ++ A+ E N +++ K+AT + +
Sbjct: 30 LSGDKSLEK--FRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQD 87
Query: 681 SPTPPAN-KLSIE-------TANDNDEK--ETDEADPAEMKLLLELNEQEATVL---RRK 727
T A+ K IE +A D ++K ET A E+ L +L EQ + +
Sbjct: 88 DQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSN 147
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
+ +L + KE + K+ +L S++ + ++ A TT ++ T S + AE + + EI
Sbjct: 148 IRDLLRFKEEVTKERDQLLSEVVKLRESLA--QTTEQQQETERSKEEAEHAISQFQQEIQ 205
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
+ + + + R E+L EL Q + + + A Q K +LQ +EQ+
Sbjct: 206 QRQNEASREFRKKEKLEKELKQIQADMDS--RQTEIKALQQYVQKSKEELQKLEQQLKEQ 263
Query: 848 RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL---ENELKEALAKI 904
+ + + E+ Q N KLQ SL ++ N +K +L E E+ + I
Sbjct: 264 KILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDI 323
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLK 934
+L I E+ KK+ TE K E + K
Sbjct: 324 GKLNKI--REQIHKKLHHTEDQKAEVEQHK 351
Score = 62.1 bits (144), Expect = 2e-08
Identities = 76/420 (18%), Positives = 173/420 (41%), Gaps = 17/420 (4%)
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
E+ E E+ +L+ LA+ S ++ + ++ + E
Sbjct: 156 EEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREF 215
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
+K +++ +K++K A++ + + ++K L+Q + + +L+Q+ +E K L
Sbjct: 216 RKKEKL----EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQ-KILNERA 270
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA---LGEIKTLQ 1505
A E +++ K + E+H + +L+ E +Q EL ++E+ +G++ ++
Sbjct: 271 AKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIR 330
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDV 1565
E++ + +K E++ +L+ ++ G EVE ++ A LD++ + RD+
Sbjct: 331 EQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMD--ELLRERDI 388
Query: 1566 LEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAE 1625
L + +E+ +R I EK R
Sbjct: 389 LNKNMLKAVNATQKQTDLVKLHEQA---KRNLEGEIQNYKDEAQKQRKIIFHLEKERDRY 445
Query: 1626 ITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH 1685
I + + M D +K Q+ +R++ + L+ Q+++ E D++
Sbjct: 446 INQASDLTQKVLMNMED-IKVRETQIFDYRKKIAESEIKLK-QQQNLYEAVRSDRNL-YS 502
Query: 1686 RNSISSTDE-EEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
+N + + DE + + K+ ++ QV L++++ KL+ E + E AE+Q
Sbjct: 503 KNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQ 562
Score = 59.3 bits (137), Expect = 1e-07
Identities = 115/614 (18%), Positives = 250/614 (40%), Gaps = 42/614 (6%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
EY+ +K+ D ++ + + ++I++ A + TA K + + + L++++
Sbjct: 42 EYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNS-AKVATALKLSQDDQTTIASLKKEIE 100
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
+ + D+++ + I ++ E+ T+ +EQ + + +L+
Sbjct: 101 KAWKMVDSAYDKEQKAKETILALKEEIVNL------TKLVEQGSGLSMDQHSNIRDLLRF 154
Query: 388 NEDMKKELRDLXXXXXXMQDNFRE--DQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
E++ KE L ++++ + +Q E + E E I + ++++ + +A
Sbjct: 155 KEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQ---EIQQRQNEA 211
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
+ ++K + EK+L +I D Q E IK L+Q V +S E +L+++L E
Sbjct: 212 SREFRKKEKLEKELKQIQADMDSRQTE--IKALQQYVQKSKEELQKLEQQLKEQKILNER 269
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ L + Q K+ + + E +Q + Q +LE +A E++ +
Sbjct: 270 AAKELEQF-QMRNAKLQQENEQHSLVCEQLSQ--ENQQKALELKAK-EEEVHQMRLDIGK 325
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDK 625
++ D + H+ ET+ N I +SK++++ ++D+
Sbjct: 326 LNKIREQIHKKLHHTEDQKAEVEQHK-ETLKNQIVGL---EREVEASKKQAELDRKAMDE 381
Query: 626 TTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPP 685
E ++ +L K + + + E + K A K R
Sbjct: 382 LLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKE 441
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKEL 745
++ I A+D +K + +++ E + R+K+ E E KQ + L
Sbjct: 442 RDRY-INQASDLTQKVLMNMED------IKVRETQIFDYRKKIAE----SEIKLKQQQNL 490
Query: 746 TSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHA 805
+ S + + A+ +T KL K++ ++DE+++ + KE +LH
Sbjct: 491 YEAVRSDRNLYSKNLVEAQDEITDMKRKL-----KIMIHQVDELKEDISAKESALVKLHL 545
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +K+ +TL L QQ ++ K ++ +QEA + EAD E+L+ +
Sbjct: 546 EQQRIEKEKETL--KAELQKLRQQALETKHFIE--KQEAEERKLLRIIAEADGERLRQKK 601
Query: 866 KKLQLLKNAKSLRS 879
+ Q++ L S
Sbjct: 602 ELDQVISERDILGS 615
Score = 57.6 bits (133), Expect = 4e-07
Identities = 137/763 (17%), Positives = 288/763 (37%), Gaps = 51/763 (6%)
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV----IEQEASVLRAK 850
E ERD + + ELS + K I+ L A +++ D +++L + E V AK
Sbjct: 18 EMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAK 77
Query: 851 TQS---LEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT-QLENELKEALAKIKE 906
+ L D++ KK ++ K K + S + K+T L+ E+ +++
Sbjct: 78 VATALKLSQDDQTTIASLKK-EIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQ 136
Query: 907 LEMICQDEKSEKK--VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
+ D+ S + +RF E KE D L S+ + +
Sbjct: 137 GSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHA 196
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE 1024
Q+ + R + + K +L+K ++ ++ ++ +K ++ K+K
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKAL----QQYVQKSK-- 250
Query: 1025 KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
+E+ ++ +L + + NE R E+ + + NAKL+ + N+ +L E +
Sbjct: 251 EELQKLEQQLK--EQKILNE--RAAKELEQFQMRNAKLQQE-----NEQHSLVCEQLSQE 301
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
NQ K L E+K +E +++++ D+ ++ + +
Sbjct: 302 NQQKAL--ELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIV 359
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
++ + + + +L ++ D+ + D + + L ++
Sbjct: 360 GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI-TLEAEMRDLKADYENKIT 1263
A R++ L E+D R+I S + M D+K E +I
Sbjct: 420 EIQNYKDE---AQKQRKIIFHLEKERD----RYINQASDLTQKVLMNMEDIKV-RETQIF 471
Query: 1264 SLESTIAAKDVHIKQLEDALRQTTNDK--YDE--ATSPVEMVEMRXXXXXXXXXXXXXQD 1319
IA ++ +KQ ++ +D+ Y + + E+ +M+ ++
Sbjct: 472 DYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKE 531
Query: 1320 ELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE 1379
+++ + L K E + E LK++L KL E
Sbjct: 532 DISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAE 591
Query: 1380 LDTDLQSERKKLDRMRIAHD---KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQE 1436
D + ++K+LD++ D + ++ ELA L K+KI + G + + ++
Sbjct: 592 ADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED 651
Query: 1437 ---YEETVKKLEHS---LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGEL-LH 1489
+KKL LA A EEL ++ ++ E + + R +E+ + L +H
Sbjct: 652 MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVH 711
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQER 1532
++L + L +K+ T ++ E+ LQE+
Sbjct: 712 RWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEK 754
Score = 47.2 bits (107), Expect = 6e-04
Identities = 126/664 (18%), Positives = 266/664 (40%), Gaps = 48/664 (7%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKL 322
+ ++Q +I+ + E ++ E++EKE I + R I +Y E+ KL
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKL 256
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA--ETL 380
+Q++ E NE E + + +++ E E Q Q Q +A L A E +
Sbjct: 257 EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
Query: 381 CEELMDEN------EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +D E + K+L ++ + +E ++ L RE+E + K +
Sbjct: 317 HQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH-KETLKNQIVGLEREVEASKKQAELD 375
Query: 435 SFKLKKTERKADQLEQE--KAEHE-KKLLEIVGGPDGMQR--ENRIKELEQEVARSTEVA 489
+ + R+ D L + KA + +K ++V + +R E I+ + E + ++
Sbjct: 376 RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKII 435
Query: 490 LRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSL----TRGGSQEDPAQLLRDLQDS 545
L++E ++ + ++ E +KV + + + E + ++L ++
Sbjct: 436 FHLEKERDRYINQASDLTQKVLM--NMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEA 493
Query: 546 LEREADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
+ + +L + L A++E + K+ + ++I ES V ++ + I
Sbjct: 494 VRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDI---SAKESALVKLHLEQQRI 550
Query: 605 HAASTPSSKEKSDSPPLSID-KTTEETQFHFDLPYLSIFNHMAANNLR--KTAARVEEDN 661
E +++ K E Q + L I LR K +V +
Sbjct: 551 EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISER 610
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLELNEQE 720
+ L QL + R+ +L+ K+ N + + + ++L ++ +E
Sbjct: 611 DILGSQLVR-----RNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRRE 665
Query: 721 ATVLRRK---VEELEQDKEALKKQV-KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
+L R VEEL Q+ +++++ KE T + + N R L + E
Sbjct: 666 KGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYE 725
Query: 777 --ERVKVLEDEIDEVRKKLIEKE---RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
+++ L+ + ++++EKE ++ E+L+ EL + + L +
Sbjct: 726 LIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLH 785
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT 891
D K+QL+V+ E ++ +++ + + EKL E LQ LK + K K T
Sbjct: 786 DKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNE---LQNLKKKYLAQKRKEQLQKNKDTA 842
Query: 892 QLEN 895
++N
Sbjct: 843 PMDN 846
Score = 45.6 bits (103), Expect = 0.002
Identities = 60/348 (17%), Positives = 143/348 (41%), Gaps = 12/348 (3%)
Query: 162 NDSLAER-VRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVN 220
++ L ER + +LK N+ +K+ + K E+ +K + + YKDE + +
Sbjct: 380 DELLRERDILNKNMLKAVNATQKQTDLVKLHEQ---AKRNLEGEIQNYKDEAQKQRKIIF 436
Query: 221 FLMQVKNS--RNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQ 278
L + ++ +++L V + +K+ Q+ E ++
Sbjct: 437 HLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRS 496
Query: 279 EVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+ ++ K + E +D+ L + +D + + + S ++KL + + E
Sbjct: 497 DRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKET 556
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELMDENEDMKKE 394
L+ E + L Q+ E + +E + + E + R I + + L + ++++ E + + +
Sbjct: 557 LKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQ 616
Query: 395 LRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAE 454
L + + + Q+ + + Q +++ R+L ++KK R+ L + A
Sbjct: 617 LVRRNDELALLYEKIKIQQS-VLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMAN 675
Query: 455 HEKKLLEIVGGPDGMQRE-NRIKELEQEVARSTEVALRLQRELAEANS 501
E+ E + +E R + LE+E+ V + E ++ N+
Sbjct: 676 VEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNA 723
Score = 42.7 bits (96), Expect = 0.013
Identities = 90/378 (23%), Positives = 163/378 (43%), Gaps = 67/378 (17%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR-LANIDTANKY-TTGRSSEV 319
V+ + + ++QI GL++EV+ +K+ E K ++L R + N + T + +++
Sbjct: 347 VEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDL 406
Query: 320 LKLQ------------------QKVNELTTHNEDLRD----EKKHLTQKIREIESELETR 357
+KL QK ++ H E RD + LTQK+ +++ R
Sbjct: 407 VKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVR 466
Query: 358 PSTEAQTR-QIEQLRAKLLAAETLCE--------------ELMDENEDMKKELRDLXXXX 402
+ R +I + KL + L E E DE DMK++L+ +
Sbjct: 467 ETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIM---- 522
Query: 403 XXMQDNFRED-QADEYSSLRRELEQ--TIKNCRVLSFKLKKTERKADQ----LEQEKAEH 455
D +ED A E + ++ LEQ K L +L+K ++A + +E+++AE
Sbjct: 523 IHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAE- 581
Query: 456 EKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ 515
E+KLL I+ DG +R + KEL+Q ++ +R++ S+ N L +
Sbjct: 582 ERKLLRIIAEADG-ERLRQKKELDQVIS---------ERDI--LGSQLVRRNDELALL-- 627
Query: 516 PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFL 575
E +K+ +S L +G SQ + Q L D++ LR + AN +++ F
Sbjct: 628 YEKIKIQQSVLNKGESQYN--QRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFH 685
Query: 576 DKQVMTDNIVTCDIHESE 593
++ + C E E
Sbjct: 686 MQRELLKERTRCRALEEE 703
>AY257469-1|AAP13528.1| 2027|Homo sapiens rho/rac-interacting citron
kinase protein.
Length = 2027
Score = 65.3 bits (152), Expect = 2e-09
Identities = 144/752 (19%), Positives = 281/752 (37%), Gaps = 53/752 (7%)
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E+++ + E+ + + K + E++ RLH +S + K L AS+ Q L++
Sbjct: 448 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQ--KEVELKASETQRSLLEQ 505
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
L E S L+ + +A E Q ++K LQLL + + +S K ++ ++
Sbjct: 506 DLATYITECSSLKRSLE--QARMEVSQEDDKALQLLHDIRE-QSRKLQEIKEQEYQAQVE 562
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
E++ + +++E +++ +S+ ++ + K K
Sbjct: 563 EMRLMMNQLEE-DLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEV 621
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK 1015
A L+ + + Q + +L KL+ K V+ E E+ ++ A +
Sbjct: 622 GEYAKLEKINAEQQLKIQ--------ELQEKLE--KAVK-ASTEATELLQNIRQAKERAE 670
Query: 1016 EMTAKTKLEKEIDE-IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYK 1074
K + ++ E IR KL ++E EK+R A+ +V+ K + + + K K
Sbjct: 671 RELEKLQNREDSSEGIRKKLV--EAEELEEKHREAQVSAQHLEVHLKQK--EQHYEEKIK 726
Query: 1075 ALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXX 1134
L+N+ +TL M+ E + ++ L ++ M +
Sbjct: 727 VLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSE 786
Query: 1135 XXXXXXXXXXQVDNYTKIDQDK-NKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLST 1193
K ++ ++L ++ + G ++I Q +
Sbjct: 787 ANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHS 846
Query: 1194 RKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRD 1253
K+R+ + H +EL + ELQ + ES+ L+A
Sbjct: 847 DKNRLLELETRLREVSLE-------HEEQKLELKRQLTELQLSLQERESQLTALQAARAA 899
Query: 1254 LKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXX 1313
L++ T LE T A + I+ L A R K+D + ++
Sbjct: 900 LESQLRQAKTELEETTAEAEEEIQAL-TAHRDEIQRKFDALRNSCTVI---TDLEEQLNQ 955
Query: 1314 XXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKL-------ENXXXXXXXXXXXX 1366
ELNN L K E+S A E+ QL+S++ L E
Sbjct: 956 LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL 1015
Query: 1367 XXXSSYWENKAKELDT---DLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNS 1423
+ E + +L+ +L + ++ + R + + + L+ L +Q+
Sbjct: 1016 KTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR 1075
Query: 1424 GAGAKRITELKQEYEETVKK-------LEHSLALEKAEYEELTGKYELLEEEHVVTK--A 1474
+RITE +Q E VK+ L+ +L +K + E L+ K LE++H + + A
Sbjct: 1076 ARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNA 1135
Query: 1475 RLTVEKEQAQGELLHVQKELSTALGEIKTLQE 1506
R +K + + EL E L + LQ+
Sbjct: 1136 RSLQQKLETERELKQRLLEEQAKLQQQMDLQK 1167
Score = 62.5 bits (145), Expect = 1e-08
Identities = 146/700 (20%), Positives = 293/700 (41%), Gaps = 55/700 (7%)
Query: 267 KEYQDQIEGLKQ-----EVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+EYQ Q+E ++ E D++ R R + +S++ RLA + K T + ++LK
Sbjct: 555 QEYQAQVEEMRLMMNQLEEDLVSAR-RRSDLYESELRESRLAAEEFKRKATECQH-KLLK 612
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELE--TRPSTEAQTRQIEQLRAKLLAAET 379
+ + L KI+E++ +LE + STEA T ++ +R AE
Sbjct: 613 AKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEA-TELLQNIRQAKERAER 671
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYS---SLRRELEQTIKNCRVLSF 436
E+L + ED + +R +++ RE Q L+++ + + +VL
Sbjct: 672 ELEKLQNR-EDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDN 730
Query: 437 KLKKTERKADQLEQEKAEHEKKLLE---IVGGPDGM--QRENRIKELEQEVARSTEVALR 491
++KK + LE HE++ E I+ M +++I+ LEQ + +E
Sbjct: 731 QIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA--- 787
Query: 492 LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
+LA +S FT N + E + T+ G E + L + + + + D
Sbjct: 788 --NKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ-D 844
Query: 552 LREQLRNAEEETANCKQVNPPTFLDKQVMTDNI--VTCDIHESETVTNSIQNKMIHAAST 609
++ R E ET ++V+ K + + + + E E+ ++Q A+
Sbjct: 845 HSDKNRLLELET-RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ------AAR 897
Query: 610 PSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLK 669
+ + + +++TT E + + + + V D E L QL
Sbjct: 898 AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLT 957
Query: 670 KMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVE 729
+ + ++ + ++ S AND + E D ++ + E + T ++ +E
Sbjct: 958 EDNAELNNQNFYLSKQLDEAS--GANDEIVQLRSEVD--HLRREITEREMQLTSQKQTME 1013
Query: 730 ELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID-E 788
L+ L++QV +L + + + A RS+ + E RV+ L+ +D E
Sbjct: 1014 ALKTTCTMLEEQVMDLEALNDELLEKER--QWEAWRSVLGDEKSQFECRVRELQRMLDTE 1071
Query: 789 VRKKLIEKERDCE-RLHAELSLAQKKPKTL-----IKSRSLDA---SDQQNVDLKRQLQV 839
+ + +R E R EL++ + K + L +K + L A SD+ N DL+++ +
Sbjct: 1072 KQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN-DLEKKHAM 1130
Query: 840 IEQEASVLRAKTQSLEADNEKLQTENKKLQL---LKNAKSLRSDKALDLNTKKTTQLENE 896
+E A L+ K ++ ++L E KLQ L+ R + L + L+ E
Sbjct: 1131 LEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTE 1190
Query: 897 LKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSK 936
+ +++ ++++ EK + + ++ TK D L++K
Sbjct: 1191 RSDLEYQLENIQVLYSHEKVKMEGTISQQTKL-IDFLQAK 1229
Score = 52.0 bits (119), Expect = 2e-05
Identities = 84/418 (20%), Positives = 176/418 (42%), Gaps = 32/418 (7%)
Query: 718 EQEATVLRRKVEELE---QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
EQE T L R+V E+E KE K + S + T ++ +RSL ++
Sbjct: 469 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEV 528
Query: 775 AEERVKVLE--DEIDEVRKKLIE-KERDCERLHAELSLAQKK-PKTLIKSRSL-DASDQQ 829
++E K L+ +I E +KL E KE++ + E+ L + + L+ +R D + +
Sbjct: 529 SQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE 588
Query: 830 NVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK 889
+ + + +++A+ + K + + E KL+ + NA+ + L +K
Sbjct: 589 LRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKI-NAEQQLKIQELQEKLEK 647
Query: 890 TTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXX 949
+ E E L I++ + E++E+++ + + ++ ++ K
Sbjct: 648 AVKASTEATELLQNIRQAK-----ERAERELEKLQNREDSSEGIRKKLVEAEELEEKHRE 702
Query: 950 XXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKN 1009
+ LK + ++ K + DL K L+ M++ E E E ++
Sbjct: 703 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSE 762
Query: 1010 AGLSGKEMTAKTK-LEKEIDEIR--SKLSKNDSEFTN---------------EKNRLQTE 1051
M +K + LE+ I E+ +KL+ N S FT +K L+T+
Sbjct: 763 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQ 822
Query: 1052 IAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
KL+ N KLE + +++ + +N L + + ++ E + ++ ++ + +L+
Sbjct: 823 AGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQ 880
Score = 50.0 bits (114), Expect = 8e-05
Identities = 87/401 (21%), Positives = 170/401 (42%), Gaps = 52/401 (12%)
Query: 271 DQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELT 330
D+I L+ EVD LR+ E E+E L + ++ T +V+ L+ +EL
Sbjct: 982 DEIVQLRSEVDHLRR--EITEREMQ--LTSQKQTMEALKTTCTMLEEQVMDLEALNDELL 1037
Query: 331 THNED-------LRDEKKHLTQKIREIESELETRPSTEA-------QTRQIEQL-----R 371
L DEK ++RE++ L+T + A ++RQ+ +L +
Sbjct: 1038 EKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHK 1097
Query: 372 AKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQ-------------ADEYS 418
A++LA + +E + E + +L DL ++ N R Q +E +
Sbjct: 1098 AEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 1157
Query: 419 SLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKEL 478
L+++++ + L+ L++ +AD L+ E+++ E +L I + ++K +
Sbjct: 1158 KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI----QVLYSHEKVK-M 1212
Query: 479 EQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQ 537
E +++ T++ LQ ++ + K G + P P V + + L +E
Sbjct: 1213 EGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKAR- 1271
Query: 538 LLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTN 597
+L+++L++ R +LR+A EE A+ K + P I I S
Sbjct: 1272 -CAELEEALQK---TRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSP---- 1323
Query: 598 SIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPY 638
Q + + PSS+ K S P + +E + H ++P+
Sbjct: 1324 EHQPSAMSLLAPPSSRRKESSTPEEFSRRLKE-RMHHNIPH 1363
Score = 48.0 bits (109), Expect = 3e-04
Identities = 81/429 (18%), Positives = 155/429 (36%), Gaps = 20/429 (4%)
Query: 1377 AKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQE 1436
A+ L+ L+ + + + D +K A+ TL+ ++ E+ + K ++E K
Sbjct: 707 AQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAM 766
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELST 1496
K+ +LE+ EL+ +L + T+ + ++E EL + L T
Sbjct: 767 INAMDSKIR---SLEQ-RIVELSEANKLAANSSLFTQRNMKAQEEMIS-ELRQQKFYLET 821
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQREREL 1556
G+++ KL + + + +N + L+ RL E E +L + E +L
Sbjct: 822 QAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQL 881
Query: 1557 RAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIE 1616
L+ + I+
Sbjct: 882 S--------LQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ 933
Query: 1617 QSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIK 1676
+ A + T T E Q+N + ++ L+NQ ++ D + + +E+
Sbjct: 934 RKFDALRNSCT-VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 992
Query: 1677 NGDKSARIHRNSISSTDE--EEYRNKVALLEQQVACLE---DELCESRLLASKLNTELVS 1731
+ + ++S + E + +LE+QV LE DEL E + L
Sbjct: 993 HLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGD 1052
Query: 1732 EKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHK-ERDEQQRLLQETST 1790
EKS E R+ E+Q L+ ++ R + R + + + HK E Q+ L+E
Sbjct: 1053 EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKL 1112
Query: 1791 LARDLRQTL 1799
A L L
Sbjct: 1113 KAESLSDKL 1121
Score = 47.6 bits (108), Expect = 5e-04
Identities = 108/601 (17%), Positives = 233/601 (38%), Gaps = 41/601 (6%)
Query: 1229 EKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQ-LEDALRQTT 1287
E +EL+ + + + LE ++ + YE KI L++ I KD+ K+ LE+ +++
Sbjct: 692 EAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQI-KKDLADKETLENMMQRHE 750
Query: 1288 NDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNA-----------KIKLEKTEAESS 1336
+ +++ E M EL+ A + ++ E S
Sbjct: 751 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMIS 810
Query: 1337 AAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRI 1396
+ + L++ KLE +N+ EL+T L+ + + ++
Sbjct: 811 ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKL 870
Query: 1397 AHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYE 1456
+ + L + +L L+ A ++ + K E EET + E + A +
Sbjct: 871 ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 930
Query: 1457 ELTGKYELLEEE-HVVTKA-----RLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT 1510
E+ K++ L V+T +LT + + + ++ K+L A G + + L +
Sbjct: 931 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQ-LRS 989
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHH 1570
E E TE + + S ++ + E + L+++ +L A ND ++LE
Sbjct: 990 EVDHLRREITEREMQLTSQKQTM-----EALKTTC-TMLEEQVMDLEALND--ELLEKER 1041
Query: 1571 DXXXXXXXXXXXXXXDYERVSKIQR---XXXXXXXXXXXXXXXXXXXIEQSEKARKAEIT 1627
RV ++QR +E + K KAEI
Sbjct: 1042 QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEIL 1101
Query: 1628 DTKTRYEGQ---MNTMRDELKSLHNQVSRFRRERDNYKQMLEA----AQKSMAEIKNGDK 1680
+ + Q ++ D+L L + + + +Q LE Q+ + E +
Sbjct: 1102 ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 1161
Query: 1681 SARIHRNSISSTDE--EEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEV 1738
+ +N I + +E ++ LL+ + + LE +L ++L S ++ S
Sbjct: 1162 QMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTK 1221
Query: 1739 RLAEMQSRLNE-YEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+ +Q+++++ ++++ L S R L T++ L +++ + ++ + L L++
Sbjct: 1222 LIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQK 1281
Query: 1798 T 1798
T
Sbjct: 1282 T 1282
>AL355378-1|CAI15667.1| 872|Homo sapiens novel protein protein.
Length = 872
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/330 (24%), Positives = 145/330 (43%), Gaps = 24/330 (7%)
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
LS DK+ E+ F + L + +N ++ A+ E N +++ K+AT + +
Sbjct: 30 LSGDKSLEK--FRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQD 87
Query: 681 SPTPPAN-KLSIE-------TANDNDEK--ETDEADPAEMKLLLELNEQEATVL---RRK 727
T A+ K IE +A D ++K ET A E+ L +L EQ + +
Sbjct: 88 DQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSN 147
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
+ +L + KE + K+ +L S++ + ++ A TT ++ T S + AE + + EI
Sbjct: 148 IRDLLRFKEEVTKERDQLLSEVVKLRESLA--QTTEQQQETERSKEEAEHAISQFQQEIQ 205
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
+ + + + R E+L EL Q + + + A Q K +LQ +EQ+
Sbjct: 206 QRQNEASREFRKKEKLEKELKQIQADMDS--RQTEIKALQQYVQKSKEELQKLEQQLKEQ 263
Query: 848 RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL---ENELKEALAKI 904
+ + + E+ Q N KLQ SL ++ N +K +L E E+ + I
Sbjct: 264 KILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDI 323
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLK 934
+L I E+ KK+ TE K E + K
Sbjct: 324 GKLNKI--REQIHKKLHHTEDQKAEVEQHK 351
Score = 62.1 bits (144), Expect = 2e-08
Identities = 76/420 (18%), Positives = 173/420 (41%), Gaps = 17/420 (4%)
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
E+ E E+ +L+ LA+ S ++ + ++ + E
Sbjct: 156 EEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREF 215
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
+K +++ +K++K A++ + + ++K L+Q + + +L+Q+ +E K L
Sbjct: 216 RKKEKL----EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQ-KILNERA 270
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA---LGEIKTLQ 1505
A E +++ K + E+H + +L+ E +Q EL ++E+ +G++ ++
Sbjct: 271 AKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIR 330
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDV 1565
E++ + +K E++ +L+ ++ G EVE ++ A LD++ + RD+
Sbjct: 331 EQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMD--ELLRERDI 388
Query: 1566 LEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAE 1625
L + +E+ +R I EK R
Sbjct: 389 LNKNMLKAVNATQKQTDLVKLHEQA---KRNLEGEIQNYKDEAQKQRKIIFHLEKERDRY 445
Query: 1626 ITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH 1685
I + + M D +K Q+ +R++ + L+ Q+++ E D++
Sbjct: 446 INQASDLTQKVLMNMED-IKVRETQIFDYRKKIAESEIKLK-QQQNLYEAVRSDRNL-YS 502
Query: 1686 RNSISSTDE-EEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
+N + + DE + + K+ ++ QV L++++ KL+ E + E AE+Q
Sbjct: 503 KNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQ 562
Score = 59.3 bits (137), Expect = 1e-07
Identities = 115/614 (18%), Positives = 250/614 (40%), Gaps = 42/614 (6%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
EY+ +K+ D ++ + + ++I++ A + TA K + + + L++++
Sbjct: 42 EYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNS-AKVATALKLSQDDQTTIASLKKEIE 100
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
+ + D+++ + I ++ E+ T+ +EQ + + +L+
Sbjct: 101 KAWKMVDSAYDKEQKAKETILALKEEIVNL------TKLVEQGSGLSMDQHSNIRDLLRF 154
Query: 388 NEDMKKELRDLXXXXXXMQDNFRE--DQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
E++ KE L ++++ + +Q E + E E I + ++++ + +A
Sbjct: 155 KEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQ---EIQQRQNEA 211
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
+ ++K + EK+L +I D Q E IK L+Q V +S E +L+++L E
Sbjct: 212 SREFRKKEKLEKELKQIQADMDSRQTE--IKALQQYVQKSKEELQKLEQQLKEQKILNER 269
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ L + Q K+ + + E +Q + Q +LE +A E++ +
Sbjct: 270 AAKELEQF-QMRNAKLQQENEQHSLVCEQLSQ--ENQQKALELKAK-EEEVHQMRLDIGK 325
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDK 625
++ D + H+ ET+ N I +SK++++ ++D+
Sbjct: 326 LNKIREQIHKKLHHTEDQKAEVEQHK-ETLKNQIVGL---EREVEASKKQAELDRKAMDE 381
Query: 626 TTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPP 685
E ++ +L K + + + E + K A K R
Sbjct: 382 LLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKE 441
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKEL 745
++ I A+D +K + +++ E + R+K+ E E KQ + L
Sbjct: 442 RDRY-INQASDLTQKVLMNMED------IKVRETQIFDYRKKIAE----SEIKLKQQQNL 490
Query: 746 TSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHA 805
+ S + + A+ +T KL K++ ++DE+++ + KE +LH
Sbjct: 491 YEAVRSDRNLYSKNLVEAQDEITDMKRKL-----KIMIHQVDELKEDISAKESALVKLHL 545
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +K+ +TL L QQ ++ K ++ +QEA + EAD E+L+ +
Sbjct: 546 EQQRIEKEKETL--KAELQKLRQQALETKHFIE--KQEAEERKLLRIIAEADGERLRQKK 601
Query: 866 KKLQLLKNAKSLRS 879
+ Q++ L S
Sbjct: 602 ELDQVISERDILGS 615
Score = 57.6 bits (133), Expect = 4e-07
Identities = 137/763 (17%), Positives = 288/763 (37%), Gaps = 51/763 (6%)
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV----IEQEASVLRAK 850
E ERD + + ELS + K I+ L A +++ D +++L + E V AK
Sbjct: 18 EMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAK 77
Query: 851 TQS---LEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT-QLENELKEALAKIKE 906
+ L D++ KK ++ K K + S + K+T L+ E+ +++
Sbjct: 78 VATALKLSQDDQTTIASLKK-EIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQ 136
Query: 907 LEMICQDEKSEKK--VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
+ D+ S + +RF E KE D L S+ + +
Sbjct: 137 GSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHA 196
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE 1024
Q+ + R + + K +L+K ++ ++ ++ +K ++ K+K
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKAL----QQYVQKSK-- 250
Query: 1025 KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
+E+ ++ +L + + NE R E+ + + NAKL+ + N+ +L E +
Sbjct: 251 EELQKLEQQLK--EQKILNE--RAAKELEQFQMRNAKLQQE-----NEQHSLVCEQLSQE 301
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
NQ K L E+K +E +++++ D+ ++ + +
Sbjct: 302 NQQKAL--ELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIV 359
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
++ + + + +L ++ D+ + D + + L ++
Sbjct: 360 GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI-TLEAEMRDLKADYENKIT 1263
A R++ L E+D R+I S + M D+K E +I
Sbjct: 420 EIQNYKDE---AQKQRKIIFHLEKERD----RYINQASDLTQKVLMNMEDIKV-RETQIF 471
Query: 1264 SLESTIAAKDVHIKQLEDALRQTTNDK--YDE--ATSPVEMVEMRXXXXXXXXXXXXXQD 1319
IA ++ +KQ ++ +D+ Y + + E+ +M+ ++
Sbjct: 472 DYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKE 531
Query: 1320 ELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE 1379
+++ + L K E + E LK++L KL E
Sbjct: 532 DISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAE 591
Query: 1380 LDTDLQSERKKLDRMRIAHD---KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQE 1436
D + ++K+LD++ D + ++ ELA L K+KI + G + + ++
Sbjct: 592 ADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED 651
Query: 1437 ---YEETVKKLEHS---LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGEL-LH 1489
+KKL LA A EEL ++ ++ E + + R +E+ + L +H
Sbjct: 652 MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVH 711
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQER 1532
++L + L +K+ T ++ E+ LQE+
Sbjct: 712 RWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEK 754
Score = 47.2 bits (107), Expect = 6e-04
Identities = 126/664 (18%), Positives = 266/664 (40%), Gaps = 48/664 (7%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKL 322
+ ++Q +I+ + E ++ E++EKE I + R I +Y E+ KL
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKL 256
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA--ETL 380
+Q++ E NE E + + +++ E E Q Q Q +A L A E +
Sbjct: 257 EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
Query: 381 CEELMDEN------EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +D E + K+L ++ + +E ++ L RE+E + K +
Sbjct: 317 HQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH-KETLKNQIVGLEREVEASKKQAELD 375
Query: 435 SFKLKKTERKADQLEQE--KAEHE-KKLLEIVGGPDGMQR--ENRIKELEQEVARSTEVA 489
+ + R+ D L + KA + +K ++V + +R E I+ + E + ++
Sbjct: 376 RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKII 435
Query: 490 LRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSL----TRGGSQEDPAQLLRDLQDS 545
L++E ++ + ++ E +KV + + + E + ++L ++
Sbjct: 436 FHLEKERDRYINQASDLTQKVLM--NMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEA 493
Query: 546 LEREADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
+ + +L + L A++E + K+ + ++I ES V ++ + I
Sbjct: 494 VRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDI---SAKESALVKLHLEQQRI 550
Query: 605 HAASTPSSKEKSDSPPLSID-KTTEETQFHFDLPYLSIFNHMAANNLR--KTAARVEEDN 661
E +++ K E Q + L I LR K +V +
Sbjct: 551 EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISER 610
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLELNEQE 720
+ L QL + R+ +L+ K+ N + + + ++L ++ +E
Sbjct: 611 DILGSQLVR-----RNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRRE 665
Query: 721 ATVLRRK---VEELEQDKEALKKQV-KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
+L R VEEL Q+ +++++ KE T + + N R L + E
Sbjct: 666 KGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYE 725
Query: 777 --ERVKVLEDEIDEVRKKLIEKE---RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
+++ L+ + ++++EKE ++ E+L+ EL + + L +
Sbjct: 726 LIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLH 785
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT 891
D K+QL+V+ E ++ +++ + + EKL E LQ LK + K K T
Sbjct: 786 DKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNE---LQNLKKKYLAQKRKEQLQKNKDTA 842
Query: 892 QLEN 895
++N
Sbjct: 843 PMDN 846
Score = 45.6 bits (103), Expect = 0.002
Identities = 60/348 (17%), Positives = 143/348 (41%), Gaps = 12/348 (3%)
Query: 162 NDSLAER-VRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVN 220
++ L ER + +LK N+ +K+ + K E+ +K + + YKDE + +
Sbjct: 380 DELLRERDILNKNMLKAVNATQKQTDLVKLHEQ---AKRNLEGEIQNYKDEAQKQRKIIF 436
Query: 221 FLMQVKNS--RNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQ 278
L + ++ +++L V + +K+ Q+ E ++
Sbjct: 437 HLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRS 496
Query: 279 EVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+ ++ K + E +D+ L + +D + + + S ++KL + + E
Sbjct: 497 DRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKET 556
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELMDENEDMKKE 394
L+ E + L Q+ E + +E + + E + R I + + L + ++++ E + + +
Sbjct: 557 LKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQ 616
Query: 395 LRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAE 454
L + + + Q+ + + Q +++ R+L ++KK R+ L + A
Sbjct: 617 LVRRNDELALLYEKIKIQQS-VLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMAN 675
Query: 455 HEKKLLEIVGGPDGMQRE-NRIKELEQEVARSTEVALRLQRELAEANS 501
E+ E + +E R + LE+E+ V + E ++ N+
Sbjct: 676 VEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNA 723
Score = 42.7 bits (96), Expect = 0.013
Identities = 90/378 (23%), Positives = 163/378 (43%), Gaps = 67/378 (17%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR-LANIDTANKY-TTGRSSEV 319
V+ + + ++QI GL++EV+ +K+ E K ++L R + N + T + +++
Sbjct: 347 VEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDL 406
Query: 320 LKLQ------------------QKVNELTTHNEDLRD----EKKHLTQKIREIESELETR 357
+KL QK ++ H E RD + LTQK+ +++ R
Sbjct: 407 VKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVR 466
Query: 358 PSTEAQTR-QIEQLRAKLLAAETLCE--------------ELMDENEDMKKELRDLXXXX 402
+ R +I + KL + L E E DE DMK++L+ +
Sbjct: 467 ETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIM---- 522
Query: 403 XXMQDNFRED-QADEYSSLRRELEQ--TIKNCRVLSFKLKKTERKADQ----LEQEKAEH 455
D +ED A E + ++ LEQ K L +L+K ++A + +E+++AE
Sbjct: 523 IHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAE- 581
Query: 456 EKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ 515
E+KLL I+ DG +R + KEL+Q ++ +R++ S+ N L +
Sbjct: 582 ERKLLRIIAEADG-ERLRQKKELDQVIS---------ERDI--LGSQLVRRNDELALL-- 627
Query: 516 PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFL 575
E +K+ +S L +G SQ + Q L D++ LR + AN +++ F
Sbjct: 628 YEKIKIQQSVLNKGESQYN--QRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFH 685
Query: 576 DKQVMTDNIVTCDIHESE 593
++ + C E E
Sbjct: 686 MQRELLKERTRCRALEEE 703
>AL162742-5|CAI12110.1| 872|Homo sapiens novel protein protein.
Length = 872
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/330 (24%), Positives = 145/330 (43%), Gaps = 24/330 (7%)
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
LS DK+ E+ F + L + +N ++ A+ E N +++ K+AT + +
Sbjct: 30 LSGDKSLEK--FRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQD 87
Query: 681 SPTPPAN-KLSIE-------TANDNDEK--ETDEADPAEMKLLLELNEQEATVL---RRK 727
T A+ K IE +A D ++K ET A E+ L +L EQ + +
Sbjct: 88 DQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSN 147
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
+ +L + KE + K+ +L S++ + ++ A TT ++ T S + AE + + EI
Sbjct: 148 IRDLLRFKEEVTKERDQLLSEVVKLRESLA--QTTEQQQETERSKEEAEHAISQFQQEIQ 205
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
+ + + + R E+L EL Q + + + A Q K +LQ +EQ+
Sbjct: 206 QRQNEASREFRKKEKLEKELKQIQADMDS--RQTEIKALQQYVQKSKEELQKLEQQLKEQ 263
Query: 848 RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL---ENELKEALAKI 904
+ + + E+ Q N KLQ SL ++ N +K +L E E+ + I
Sbjct: 264 KILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDI 323
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLK 934
+L I E+ KK+ TE K E + K
Sbjct: 324 GKLNKI--REQIHKKLHHTEDQKAEVEQHK 351
Score = 62.1 bits (144), Expect = 2e-08
Identities = 76/420 (18%), Positives = 173/420 (41%), Gaps = 17/420 (4%)
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
E+ E E+ +L+ LA+ S ++ + ++ + E
Sbjct: 156 EEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREF 215
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
+K +++ +K++K A++ + + ++K L+Q + + +L+Q+ +E K L
Sbjct: 216 RKKEKL----EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQ-KILNERA 270
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA---LGEIKTLQ 1505
A E +++ K + E+H + +L+ E +Q EL ++E+ +G++ ++
Sbjct: 271 AKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIR 330
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDV 1565
E++ + +K E++ +L+ ++ G EVE ++ A LD++ + RD+
Sbjct: 331 EQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMD--ELLRERDI 388
Query: 1566 LEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAE 1625
L + +E+ +R I EK R
Sbjct: 389 LNKNMLKAVNATQKQTDLVKLHEQA---KRNLEGEIQNYKDEAQKQRKIIFHLEKERDRY 445
Query: 1626 ITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH 1685
I + + M D +K Q+ +R++ + L+ Q+++ E D++
Sbjct: 446 INQASDLTQKVLMNMED-IKVRETQIFDYRKKIAESEIKLK-QQQNLYEAVRSDRNL-YS 502
Query: 1686 RNSISSTDE-EEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEVRLAEMQ 1744
+N + + DE + + K+ ++ QV L++++ KL+ E + E AE+Q
Sbjct: 503 KNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQ 562
Score = 59.3 bits (137), Expect = 1e-07
Identities = 115/614 (18%), Positives = 250/614 (40%), Gaps = 42/614 (6%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
EY+ +K+ D ++ + + ++I++ A + TA K + + + L++++
Sbjct: 42 EYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNS-AKVATALKLSQDDQTTIASLKKEIE 100
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
+ + D+++ + I ++ E+ T+ +EQ + + +L+
Sbjct: 101 KAWKMVDSAYDKEQKAKETILALKEEIVNL------TKLVEQGSGLSMDQHSNIRDLLRF 154
Query: 388 NEDMKKELRDLXXXXXXMQDNFRE--DQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
E++ KE L ++++ + +Q E + E E I + ++++ + +A
Sbjct: 155 KEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQ---EIQQRQNEA 211
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
+ ++K + EK+L +I D Q E IK L+Q V +S E +L+++L E
Sbjct: 212 SREFRKKEKLEKELKQIQADMDSRQTE--IKALQQYVQKSKEELQKLEQQLKEQKILNER 269
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ L + Q K+ + + E +Q + Q +LE +A E++ +
Sbjct: 270 AAKELEQF-QMRNAKLQQENEQHSLVCEQLSQ--ENQQKALELKAK-EEEVHQMRLDIGK 325
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDK 625
++ D + H+ ET+ N I +SK++++ ++D+
Sbjct: 326 LNKIREQIHKKLHHTEDQKAEVEQHK-ETLKNQIVGL---EREVEASKKQAELDRKAMDE 381
Query: 626 TTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPP 685
E ++ +L K + + + E + K A K R
Sbjct: 382 LLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKE 441
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKEL 745
++ I A+D +K + +++ E + R+K+ E E KQ + L
Sbjct: 442 RDRY-INQASDLTQKVLMNMED------IKVRETQIFDYRKKIAE----SEIKLKQQQNL 490
Query: 746 TSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHA 805
+ S + + A+ +T KL K++ ++DE+++ + KE +LH
Sbjct: 491 YEAVRSDRNLYSKNLVEAQDEITDMKRKL-----KIMIHQVDELKEDISAKESALVKLHL 545
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E +K+ +TL L QQ ++ K ++ +QEA + EAD E+L+ +
Sbjct: 546 EQQRIEKEKETL--KAELQKLRQQALETKHFIE--KQEAEERKLLRIIAEADGERLRQKK 601
Query: 866 KKLQLLKNAKSLRS 879
+ Q++ L S
Sbjct: 602 ELDQVISERDILGS 615
Score = 57.6 bits (133), Expect = 4e-07
Identities = 137/763 (17%), Positives = 288/763 (37%), Gaps = 51/763 (6%)
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV----IEQEASVLRAK 850
E ERD + + ELS + K I+ L A +++ D +++L + E V AK
Sbjct: 18 EMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAK 77
Query: 851 TQS---LEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT-QLENELKEALAKIKE 906
+ L D++ KK ++ K K + S + K+T L+ E+ +++
Sbjct: 78 VATALKLSQDDQTTIASLKK-EIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQ 136
Query: 907 LEMICQDEKSEKK--VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
+ D+ S + +RF E KE D L S+ + +
Sbjct: 137 GSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHA 196
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE 1024
Q+ + R + + K +L+K ++ ++ ++ +K ++ K+K
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKAL----QQYVQKSK-- 250
Query: 1025 KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
+E+ ++ +L + + NE R E+ + + NAKL+ + N+ +L E +
Sbjct: 251 EELQKLEQQLK--EQKILNE--RAAKELEQFQMRNAKLQQE-----NEQHSLVCEQLSQE 301
Query: 1085 NQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXX 1144
NQ K L E+K +E +++++ D+ ++ + +
Sbjct: 302 NQQKAL--ELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIV 359
Query: 1145 QVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXX 1204
++ + + + +L ++ D+ + D + + L ++
Sbjct: 360 GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
Query: 1205 XXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFI-TLEAEMRDLKADYENKIT 1263
A R++ L E+D R+I S + M D+K E +I
Sbjct: 420 EIQNYKDE---AQKQRKIIFHLEKERD----RYINQASDLTQKVLMNMEDIKV-RETQIF 471
Query: 1264 SLESTIAAKDVHIKQLEDALRQTTNDK--YDE--ATSPVEMVEMRXXXXXXXXXXXXXQD 1319
IA ++ +KQ ++ +D+ Y + + E+ +M+ ++
Sbjct: 472 DYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKE 531
Query: 1320 ELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKE 1379
+++ + L K E + E LK++L KL E
Sbjct: 532 DISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAE 591
Query: 1380 LDTDLQSERKKLDRMRIAHD---KDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQE 1436
D + ++K+LD++ D + ++ ELA L K+KI + G + + ++
Sbjct: 592 ADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED 651
Query: 1437 ---YEETVKKLEHS---LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGEL-LH 1489
+KKL LA A EEL ++ ++ E + + R +E+ + L +H
Sbjct: 652 MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVH 711
Query: 1490 VQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQER 1532
++L + L +K+ T ++ E+ LQE+
Sbjct: 712 RWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEK 754
Score = 47.2 bits (107), Expect = 6e-04
Identities = 126/664 (18%), Positives = 266/664 (40%), Gaps = 48/664 (7%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKL 322
+ ++Q +I+ + E ++ E++EKE I + R I +Y E+ KL
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKL 256
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAA--ETL 380
+Q++ E NE E + + +++ E E Q Q Q +A L A E +
Sbjct: 257 EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
Query: 381 CEELMDEN------EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVL 434
+ +D E + K+L ++ + +E ++ L RE+E + K +
Sbjct: 317 HQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH-KETLKNQIVGLEREVEASKKQAELD 375
Query: 435 SFKLKKTERKADQLEQE--KAEHE-KKLLEIVGGPDGMQR--ENRIKELEQEVARSTEVA 489
+ + R+ D L + KA + +K ++V + +R E I+ + E + ++
Sbjct: 376 RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKII 435
Query: 490 LRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSL----TRGGSQEDPAQLLRDLQDS 545
L++E ++ + ++ E +KV + + + E + ++L ++
Sbjct: 436 FHLEKERDRYINQASDLTQKVLM--NMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEA 493
Query: 546 LEREADL-REQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
+ + +L + L A++E + K+ + ++I ES V ++ + I
Sbjct: 494 VRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDI---SAKESALVKLHLEQQRI 550
Query: 605 HAASTPSSKEKSDSPPLSID-KTTEETQFHFDLPYLSIFNHMAANNLR--KTAARVEEDN 661
E +++ K E Q + L I LR K +V +
Sbjct: 551 EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISER 610
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLELNEQE 720
+ L QL + R+ +L+ K+ N + + + ++L ++ +E
Sbjct: 611 DILGSQLVR-----RNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRRE 665
Query: 721 ATVLRRK---VEELEQDKEALKKQV-KELTSKISSVTKTSAGSNTTARRSLTTNSNKLAE 776
+L R VEEL Q+ +++++ KE T + + N R L + E
Sbjct: 666 KGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYE 725
Query: 777 --ERVKVLEDEIDEVRKKLIEKE---RDCERLHAELSLAQKKPKTLIKSRSLDASDQQNV 831
+++ L+ + ++++EKE ++ E+L+ EL + + L +
Sbjct: 726 LIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLH 785
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT 891
D K+QL+V+ E ++ +++ + + EKL E LQ LK + K K T
Sbjct: 786 DKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNE---LQNLKKKYLAQKRKEQLQKNKDTA 842
Query: 892 QLEN 895
++N
Sbjct: 843 PMDN 846
Score = 45.6 bits (103), Expect = 0.002
Identities = 60/348 (17%), Positives = 143/348 (41%), Gaps = 12/348 (3%)
Query: 162 NDSLAER-VRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVN 220
++ L ER + +LK N+ +K+ + K E+ +K + + YKDE + +
Sbjct: 380 DELLRERDILNKNMLKAVNATQKQTDLVKLHEQ---AKRNLEGEIQNYKDEAQKQRKIIF 436
Query: 221 FLMQVKNS--RNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQ 278
L + ++ +++L V + +K+ Q+ E ++
Sbjct: 437 HLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRS 496
Query: 279 EVDILRKRCERVEKEKSDI---LLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNED 335
+ ++ K + E +D+ L + +D + + + S ++KL + + E
Sbjct: 497 DRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKET 556
Query: 336 LRDEKKHLTQKIREIESELETRPSTEAQT-RQIEQLRAKLLAAETLCEELMDENEDMKKE 394
L+ E + L Q+ E + +E + + E + R I + + L + ++++ E + + +
Sbjct: 557 LKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQ 616
Query: 395 LRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAE 454
L + + + Q+ + + Q +++ R+L ++KK R+ L + A
Sbjct: 617 LVRRNDELALLYEKIKIQQS-VLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMAN 675
Query: 455 HEKKLLEIVGGPDGMQRE-NRIKELEQEVARSTEVALRLQRELAEANS 501
E+ E + +E R + LE+E+ V + E ++ N+
Sbjct: 676 VEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNA 723
Score = 42.7 bits (96), Expect = 0.013
Identities = 90/378 (23%), Positives = 163/378 (43%), Gaps = 67/378 (17%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR-LANIDTANKY-TTGRSSEV 319
V+ + + ++QI GL++EV+ +K+ E K ++L R + N + T + +++
Sbjct: 347 VEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDL 406
Query: 320 LKLQ------------------QKVNELTTHNEDLRD----EKKHLTQKIREIESELETR 357
+KL QK ++ H E RD + LTQK+ +++ R
Sbjct: 407 VKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVR 466
Query: 358 PSTEAQTR-QIEQLRAKLLAAETLCE--------------ELMDENEDMKKELRDLXXXX 402
+ R +I + KL + L E E DE DMK++L+ +
Sbjct: 467 ETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIM---- 522
Query: 403 XXMQDNFRED-QADEYSSLRRELEQ--TIKNCRVLSFKLKKTERKADQ----LEQEKAEH 455
D +ED A E + ++ LEQ K L +L+K ++A + +E+++AE
Sbjct: 523 IHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAE- 581
Query: 456 EKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ 515
E+KLL I+ DG +R + KEL+Q ++ +R++ S+ N L +
Sbjct: 582 ERKLLRIIAEADG-ERLRQKKELDQVIS---------ERDI--LGSQLVRRNDELALL-- 627
Query: 516 PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFL 575
E +K+ +S L +G SQ + Q L D++ LR + AN +++ F
Sbjct: 628 YEKIKIQQSVLNKGESQYN--QRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFH 685
Query: 576 DKQVMTDNIVTCDIHESE 593
++ + C E E
Sbjct: 686 MQRELLKERTRCRALEEE 703
>AL157400-5|CAI16831.1| 1780|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1780
Score = 65.3 bits (152), Expect = 2e-09
Identities = 166/888 (18%), Positives = 352/888 (39%), Gaps = 68/888 (7%)
Query: 269 YQDQIEGLKQEVDILRK--RCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
+++ +E L ++ D++ + E + ++ +L L NK E KL +
Sbjct: 522 WENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHE-EKRKLLDLI 580
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETR---------PSTEAQTRQIEQLRAKLLAA 377
+L + + EK L KIRE ++ T+ T Q R+I + A+ A
Sbjct: 581 EDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLA 640
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
+ ++L+ + + ++ +D+ ++ + +++ ++ EL +T +
Sbjct: 641 --IFKDLVGKCDTREEAAKDICATKVETEEATACLEL-KFNQIKAELAKTKGELIKTKEE 697
Query: 438 LKKTERKADQLEQEKAEHEKKLL-------EIVGGPDGMQRENRIKELEQEVARSTEVAL 490
LKK E ++D L QE KK++ E++ D Q+E+ I E Q + E
Sbjct: 698 LKKRENESDSLIQELETSNKKIITQNQRIKELINIID--QKEDTINEF-QNLKSHMENTF 754
Query: 491 RLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD----LQDSL 546
+ + A+ +S N L+ E K S+S + + + +L +D + S+
Sbjct: 755 KCN-DKADTSSLII--NNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSI 811
Query: 547 EREADLREQLRNAEEETANCKQVNPPTFLDK--QVMTDNIVTCD--IHESETVTNSIQNK 602
+ + E + +EE N ++ L + + + ++T + + + + +
Sbjct: 812 HVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQ 871
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN-----LRKTAARV 657
++H S EK + L++ K ++ Q ++D+ + + N + K + +
Sbjct: 872 IVHFQQELSLSEKKN---LTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEI 928
Query: 658 EEDNESL---LLQLKKMATKARS-RKLSPTPPANKLSIETAND-NDEKETDEADPAEMKL 712
E S+ + Q+K M TK R L + + + D ++ E D ++ L
Sbjct: 929 ETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDL 988
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L V +++E ++ + ++ + + + K S+ + L
Sbjct: 989 LGNDYLVSKQVKEYRIQEPNREN-SFHSSIEAIWEECKEIVKASSKKSHQIEE-LEQQIE 1046
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
KL E VK +DE + +++K + + D + E + Q K + K+ +LD Q V+
Sbjct: 1047 KLQAE-VKGYKDENNRLKEKEHKNQDDLLK-EKETLIQQLKEELQEKNVTLDVQIQHVVE 1104
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
KR L + Q + +AK + LE E + E L+ + L L + +
Sbjct: 1105 GKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE-RNLKE 1163
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXX 952
+ L++++ K+L + + + E+ + T + L+ K+
Sbjct: 1164 FQEHLQDSVKNTKDLN-VKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKE 1222
Query: 953 XXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAG 1011
A ++LK D Q R + DL KL KK ++ ++ E+ M K
Sbjct: 1223 ELSASSARTQNLKADLQ-----RKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLR 1277
Query: 1012 LSGKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEK--NRLQTEIAKLKDVNAKLEGDKDV 1068
+ E+ K + +E+D + + + + N+K +Q KD+N K + +
Sbjct: 1278 IKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVK----EKI 1333
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+ LE + Q + L +++ E +L + L+T
Sbjct: 1334 IEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLET 1381
Score = 56.8 bits (131), Expect = 7e-07
Identities = 150/799 (18%), Positives = 331/799 (41%), Gaps = 71/799 (8%)
Query: 343 LTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXX 402
L K +I++EL +T+ E+L+ + +++L +EL N+ + + + +
Sbjct: 673 LELKFNQIKAELAKTKGELIKTK--EELKKRENESDSLIQELETSNKKIITQNQRIKELI 730
Query: 403 XXMQDNFREDQADEYSSLRRELEQTIK-NCRVLSFKLKKTERKADQLEQEKAEHEKKLLE 461
+ +ED +E+ +L+ +E T K N + + L + + E E K
Sbjct: 731 NIIDQ--KEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKL---ICNETVEVPKDSKS 785
Query: 462 IVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKV 521
+ EN EL+Q+ + + ++ + + E K P++ ++ E ++V
Sbjct: 786 KICSERKRVNEN---ELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEI---EDIRV 839
Query: 522 SRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMT 581
+ + G + + +L++ E +A+L +Q+ + ++E + ++ N + Q +
Sbjct: 840 LQEN--NEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQ 897
Query: 582 DN--IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHF-DLPY 638
N I ++H ++ + K++ ++ + +S + +S K L
Sbjct: 898 SNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDS 957
Query: 639 LSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDND 698
+S +++ NLR + EEDN L ++ +S ++ E +N
Sbjct: 958 VSQISNIDLLNLRDLSNGSEEDN----LPNTQLDLLGNDYLVSKQVKEYRIQ-EPNRENS 1012
Query: 699 EKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ EA E K +++ + +++ ++EELEQ E L+ +VK + + + +
Sbjct: 1013 FHSSIEAIWEECKEIVKASSKKS----HQIEELEQQIEKLQAEVKGYKDENNRLKEKEHK 1068
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK--- 815
+ + T +L EE ++ +D + ++E +R L ++ + K K
Sbjct: 1069 NQDDLLKEKETLIQQLKEE-LQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELE 1127
Query: 816 TLIKSRSLDASDQQNVD------------LKRQLQVIEQEASVLRAKTQSLEADNEKLQT 863
T+++++ ++ S ++ L+R L+ ++ T+ L KL+
Sbjct: 1128 TILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKE 1187
Query: 864 E----NKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQ---DEKS 916
E LQ +K+ L+ ++ + N ++T +L+ EL + A+ + L+ Q ++ +
Sbjct: 1188 EITQLTNNLQDMKHLLQLKEEEE-ETNRQETEKLKEELSASSARTQNLKADLQRKEEDYA 1246
Query: 917 EKKVRFTEATK------KETDTLKSKQXXXXXXXXXXXXX----XXXXXXXQATLKSLKD 966
+ K + T+A K KE ++ + Q T++ LK+
Sbjct: 1247 DLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKE 1306
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLK-KMVEDLEC--EIGEMYVVMKNAGLSGKEMTAK--- 1020
++ L +K K++ED+ E E V ++ L K +
Sbjct: 1307 QLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLA 1366
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL-EGDKDVFANKYKALENE 1079
T+LEK ++ +KN+ E + KL ++ +L E ++ A++ K LE E
Sbjct: 1367 TELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLE-E 1425
Query: 1080 NSNLSNQCKTLTEEMKNRE 1098
L Q K E ++N+E
Sbjct: 1426 KMMLITQAKE-AENIRNKE 1443
Score = 54.0 bits (124), Expect = 5e-06
Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 23/302 (7%)
Query: 1384 LQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE-QNSGAGAKRITELKQEYEET-- 1440
L+ ER + D KD + LK K +I + N+ K + +LK+E EET
Sbjct: 1155 LKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNR 1214
Query: 1441 --VKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
+KL+ L+ A + L + EE++ K +LT K+Q + VQKE+S
Sbjct: 1215 QETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQ----IKQVQKEVSVMR 1270
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEM---QNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
E K L+ K+ N E+ Q +I L+E+L +VE A + Q ER
Sbjct: 1271 DEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL--NNQKVEEA-----IQQYERA 1323
Query: 1556 LRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXI 1615
+ N + ++E + ++V + + +
Sbjct: 1324 CKDLNVKEKIIE----DMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1379
Query: 1616 EQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI 1675
E R + + T G++ ++DEL+ + + R++ K ML K I
Sbjct: 1380 ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENI 1439
Query: 1676 KN 1677
+N
Sbjct: 1440 RN 1441
Score = 35.1 bits (77), Expect = 2.6
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 15/165 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+K+ Q ++ ++ E +LR + +EK+K+ +D + T + E L QK
Sbjct: 1259 IKQVQKEVSVMRDEDKLLRIKINELEKKKNQC----SQELDMKQR-TIQQLKEQLN-NQK 1312
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
V E E + + I ++ LE + T+ + Q+ L AKL E L EL
Sbjct: 1313 VEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQV--LEAKLEEVERLATEL- 1369
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQAD---EYSSLRRELEQT 427
E K++ DL + E+ D + ++L+ EL+++
Sbjct: 1370 ---EKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQES 1411
>AL157389-3|CAI12887.1| 1780|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1780
Score = 65.3 bits (152), Expect = 2e-09
Identities = 166/888 (18%), Positives = 352/888 (39%), Gaps = 68/888 (7%)
Query: 269 YQDQIEGLKQEVDILRK--RCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
+++ +E L ++ D++ + E + ++ +L L NK E KL +
Sbjct: 522 WENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHE-EKRKLLDLI 580
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETR---------PSTEAQTRQIEQLRAKLLAA 377
+L + + EK L KIRE ++ T+ T Q R+I + A+ A
Sbjct: 581 EDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLA 640
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
+ ++L+ + + ++ +D+ ++ + +++ ++ EL +T +
Sbjct: 641 --IFKDLVGKCDTREEAAKDICATKVETEEATACLEL-KFNQIKAELAKTKGELIKTKEE 697
Query: 438 LKKTERKADQLEQEKAEHEKKLL-------EIVGGPDGMQRENRIKELEQEVARSTEVAL 490
LKK E ++D L QE KK++ E++ D Q+E+ I E Q + E
Sbjct: 698 LKKRENESDSLIQELETSNKKIITQNQRIKELINIID--QKEDTINEF-QNLKSHMENTF 754
Query: 491 RLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRD----LQDSL 546
+ + A+ +S N L+ E K S+S + + + +L +D + S+
Sbjct: 755 KCN-DKADTSSLII--NNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSI 811
Query: 547 EREADLREQLRNAEEETANCKQVNPPTFLDK--QVMTDNIVTCD--IHESETVTNSIQNK 602
+ + E + +EE N ++ L + + + ++T + + + + +
Sbjct: 812 HVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQ 871
Query: 603 MIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANN-----LRKTAARV 657
++H S EK + L++ K ++ Q ++D+ + + N + K + +
Sbjct: 872 IVHFQQELSLSEKKN---LTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEI 928
Query: 658 EEDNESL---LLQLKKMATKARS-RKLSPTPPANKLSIETAND-NDEKETDEADPAEMKL 712
E S+ + Q+K M TK R L + + + D ++ E D ++ L
Sbjct: 929 ETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDL 988
Query: 713 LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSN 772
L V +++E ++ + ++ + + + K S+ + L
Sbjct: 989 LGNDYLVSKQVKEYRIQEPNREN-SFHSSIEAIWEECKEIVKASSKKSHQIEE-LEQQIE 1046
Query: 773 KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
KL E VK +DE + +++K + + D + E + Q K + K+ +LD Q V+
Sbjct: 1047 KLQAE-VKGYKDENNRLKEKEHKNQDDLLK-EKETLIQQLKEELQEKNVTLDVQIQHVVE 1104
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
KR L + Q + +AK + LE E + E L+ + L L + +
Sbjct: 1105 GKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLE-RNLKE 1163
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXX 952
+ L++++ K+L + + + E+ + T + L+ K+
Sbjct: 1164 FQEHLQDSVKNTKDLN-VKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKE 1222
Query: 953 XXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAG 1011
A ++LK D Q R + DL KL KK ++ ++ E+ M K
Sbjct: 1223 ELSASSARTQNLKADLQ-----RKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLR 1277
Query: 1012 LSGKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEK--NRLQTEIAKLKDVNAKLEGDKDV 1068
+ E+ K + +E+D + + + + N+K +Q KD+N K + +
Sbjct: 1278 IKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVK----EKI 1333
Query: 1069 FANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQT 1116
+ LE + Q + L +++ E +L + L+T
Sbjct: 1334 IEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLET 1381
Score = 56.8 bits (131), Expect = 7e-07
Identities = 150/799 (18%), Positives = 331/799 (41%), Gaps = 71/799 (8%)
Query: 343 LTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXX 402
L K +I++EL +T+ E+L+ + +++L +EL N+ + + + +
Sbjct: 673 LELKFNQIKAELAKTKGELIKTK--EELKKRENESDSLIQELETSNKKIITQNQRIKELI 730
Query: 403 XXMQDNFREDQADEYSSLRRELEQTIK-NCRVLSFKLKKTERKADQLEQEKAEHEKKLLE 461
+ +ED +E+ +L+ +E T K N + + L + + E E K
Sbjct: 731 NIIDQ--KEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKL---ICNETVEVPKDSKS 785
Query: 462 IVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKV 521
+ EN EL+Q+ + + ++ + + E K P++ ++ E ++V
Sbjct: 786 KICSERKRVNEN---ELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEI---EDIRV 839
Query: 522 SRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMT 581
+ + G + + +L++ E +A+L +Q+ + ++E + ++ N + Q +
Sbjct: 840 LQEN--NEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQ 897
Query: 582 DN--IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHF-DLPY 638
N I ++H ++ + K++ ++ + +S + +S K L
Sbjct: 898 SNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDS 957
Query: 639 LSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDND 698
+S +++ NLR + EEDN L ++ +S ++ E +N
Sbjct: 958 VSQISNIDLLNLRDLSNGSEEDN----LPNTQLDLLGNDYLVSKQVKEYRIQ-EPNRENS 1012
Query: 699 EKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
+ EA E K +++ + +++ ++EELEQ E L+ +VK + + + +
Sbjct: 1013 FHSSIEAIWEECKEIVKASSKKS----HQIEELEQQIEKLQAEVKGYKDENNRLKEKEHK 1068
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPK--- 815
+ + T +L EE ++ +D + ++E +R L ++ + K K
Sbjct: 1069 NQDDLLKEKETLIQQLKEE-LQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELE 1127
Query: 816 TLIKSRSLDASDQQNVD------------LKRQLQVIEQEASVLRAKTQSLEADNEKLQT 863
T+++++ ++ S ++ L+R L+ ++ T+ L KL+
Sbjct: 1128 TILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKE 1187
Query: 864 E----NKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQ---DEKS 916
E LQ +K+ L+ ++ + N ++T +L+ EL + A+ + L+ Q ++ +
Sbjct: 1188 EITQLTNNLQDMKHLLQLKEEEE-ETNRQETEKLKEELSASSARTQNLKADLQRKEEDYA 1246
Query: 917 EKKVRFTEATK------KETDTLKSKQXXXXXXXXXXXXX----XXXXXXXQATLKSLKD 966
+ K + T+A K KE ++ + Q T++ LK+
Sbjct: 1247 DLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKE 1306
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLK-KMVEDLEC--EIGEMYVVMKNAGLSGKEMTAK--- 1020
++ L +K K++ED+ E E V ++ L K +
Sbjct: 1307 QLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLA 1366
Query: 1021 TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL-EGDKDVFANKYKALENE 1079
T+LEK ++ +KN+ E + KL ++ +L E ++ A++ K LE E
Sbjct: 1367 TELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLE-E 1425
Query: 1080 NSNLSNQCKTLTEEMKNRE 1098
L Q K E ++N+E
Sbjct: 1426 KMMLITQAKE-AENIRNKE 1443
Score = 54.0 bits (124), Expect = 5e-06
Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 23/302 (7%)
Query: 1384 LQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE-QNSGAGAKRITELKQEYEET-- 1440
L+ ER + D KD + LK K +I + N+ K + +LK+E EET
Sbjct: 1155 LKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNR 1214
Query: 1441 --VKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
+KL+ L+ A + L + EE++ K +LT K+Q + VQKE+S
Sbjct: 1215 QETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQ----IKQVQKEVSVMR 1270
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEM---QNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
E K L+ K+ N E+ Q +I L+E+L +VE A + Q ER
Sbjct: 1271 DEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL--NNQKVEEA-----IQQYERA 1323
Query: 1556 LRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXI 1615
+ N + ++E + ++V + + +
Sbjct: 1324 CKDLNVKEKIIE----DMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 1379
Query: 1616 EQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI 1675
E R + + T G++ ++DEL+ + + R++ K ML K I
Sbjct: 1380 ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENI 1439
Query: 1676 KN 1677
+N
Sbjct: 1440 RN 1441
Score = 35.1 bits (77), Expect = 2.6
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 15/165 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+K+ Q ++ ++ E +LR + +EK+K+ +D + T + E L QK
Sbjct: 1259 IKQVQKEVSVMRDEDKLLRIKINELEKKKNQC----SQELDMKQR-TIQQLKEQLN-NQK 1312
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
V E E + + I ++ LE + T+ + Q+ L AKL E L EL
Sbjct: 1313 VEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQV--LEAKLEEVERLATEL- 1369
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQAD---EYSSLRRELEQT 427
E K++ DL + E+ D + ++L+ EL+++
Sbjct: 1370 ---EKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQES 1411
>AK093227-1|BAC04102.1| 550|Homo sapiens protein ( Homo sapiens
cDNA FLJ35908 fis, clone TESTI2009935. ).
Length = 550
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/330 (24%), Positives = 145/330 (43%), Gaps = 24/330 (7%)
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKL 680
LS DK+ E+ F + L + +N ++ A+ E N +++ K+AT + +
Sbjct: 30 LSGDKSLEK--FRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQD 87
Query: 681 SPTPPAN-KLSIE-------TANDNDEK--ETDEADPAEMKLLLELNEQEATVL---RRK 727
T A+ K IE +A D ++K ET A E+ L +L EQ + +
Sbjct: 88 DQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSN 147
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID 787
+ +L + KE + K+ +L S++ + ++ A TT ++ T S + AE + + EI
Sbjct: 148 IRDLLRFKEEVTKERDQLLSEVVKLRESLA--QTTEQQQETERSKEEAEHAISQFQQEIQ 205
Query: 788 EVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVL 847
+ + + + R E+L EL Q + + + A Q K +LQ +EQ+
Sbjct: 206 QRQNEASREFRKKEKLEKELKQIQADMDS--RQTEIKALQQYVQKSKEELQKLEQQLKEQ 263
Query: 848 RAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQL---ENELKEALAKI 904
+ + + E+ Q N KLQ SL ++ N +K +L E E+ + I
Sbjct: 264 KILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDI 323
Query: 905 KELEMICQDEKSEKKVRFTEATKKETDTLK 934
+L I E+ KK+ TE K E + K
Sbjct: 324 GKLNKI--REQIHKKLHHTEDQKAEVEQHK 351
Score = 58.4 bits (135), Expect = 2e-07
Identities = 72/404 (17%), Positives = 167/404 (41%), Gaps = 17/404 (4%)
Query: 1329 EKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSER 1388
E+ E E+ +L+ LA+ S ++ + ++ + E
Sbjct: 156 EEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREF 215
Query: 1389 KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSL 1448
+K +++ +K++K A++ + + ++K L+Q + + +L+Q+ +E K L
Sbjct: 216 RKKEKL----EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQ-KILNERA 270
Query: 1449 ALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTA---LGEIKTLQ 1505
A E +++ K + E+H + +L+ E +Q EL ++E+ +G++ ++
Sbjct: 271 AKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIR 330
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDV 1565
E++ + +K E++ +L+ ++ G EVE ++ A LD++ + RD+
Sbjct: 331 EQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMD--ELLRERDI 388
Query: 1566 LEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAE 1625
L + +E+ +R I EK R
Sbjct: 389 LNKNMLKAVNATQKQTDLVKLHEQA---KRNLEGEIQNYKDEAQKQRKIIFHLEKERDRY 445
Query: 1626 ITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIH 1685
I + + M D +K Q+ +R++ + L+ Q+++ E D++
Sbjct: 446 INQASDLTQKVLMNMED-IKVRETQIFDYRKKIAESEIKLK-QQQNLYEAVRSDRNL-YS 502
Query: 1686 RNSISSTDE-EEYRNKVALLEQQVACLEDELCESRLLASKLNTE 1728
+N + + DE + + K+ ++ QV L++++ KL+ E
Sbjct: 503 KNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLE 546
Score = 45.2 bits (102), Expect = 0.002
Identities = 97/541 (17%), Positives = 217/541 (40%), Gaps = 38/541 (7%)
Query: 268 EYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVN 327
EY+ +K+ D ++ + + ++I++ A + TA K + + + L++++
Sbjct: 42 EYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNS-AKVATALKLSQDDQTTIASLKKEIE 100
Query: 328 ELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDE 387
+ + D+++ + I ++ E+ T+ +EQ + + +L+
Sbjct: 101 KAWKMVDSAYDKEQKAKETILALKEEIVNL------TKLVEQGSGLSMDQHSNIRDLLRF 154
Query: 388 NEDMKKELRDLXXXXXXMQDNFRE--DQADEYSSLRRELEQTIKNCRVLSFKLKKTERKA 445
E++ KE L ++++ + +Q E + E E I + ++++ + +A
Sbjct: 155 KEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQ---EIQQRQNEA 211
Query: 446 DQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTG 505
+ ++K + EK+L +I D Q E IK L+Q V +S E +L+++L E
Sbjct: 212 SREFRKKEKLEKELKQIQADMDSRQTE--IKALQQYVQKSKEELQKLEQQLKEQKILNER 269
Query: 506 SNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETAN 565
+ L + Q K+ + + E +Q + Q +LE +A E++ +
Sbjct: 270 AAKELEQF-QMRNAKLQQENEQHSLVCEQLSQ--ENQQKALELKAK-EEEVHQMRLDIGK 325
Query: 566 CKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDK 625
++ D + H+ ET+ N I +SK++++ ++D+
Sbjct: 326 LNKIREQIHKKLHHTEDQKAEVEQHK-ETLKNQIVGL---EREVEASKKQAELDRKAMDE 381
Query: 626 TTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPP 685
E ++ +L K + + + E + K A K R
Sbjct: 382 LLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKE 441
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKEL 745
++ I A+D +K + +++ E + R+K+ E E KQ + L
Sbjct: 442 RDRY-INQASDLTQKVLMNMED------IKVRETQIFDYRKKIAE----SEIKLKQQQNL 490
Query: 746 TSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHA 805
+ S + + A+ +T KL K++ ++DE+++ + KE +LH
Sbjct: 491 YEAVRSDRNLYSKNLVEAQDEITDMKRKL-----KIMIHQVDELKEDISAKESALVKLHL 545
Query: 806 E 806
E
Sbjct: 546 E 546
Score = 41.1 bits (92), Expect = 0.039
Identities = 65/321 (20%), Positives = 131/321 (40%), Gaps = 21/321 (6%)
Query: 795 EKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV----IEQEASVLRAK 850
E ERD + + ELS + K I+ L A +++ D +++L + E V AK
Sbjct: 18 EMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAK 77
Query: 851 TQS---LEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT-QLENELKEALAKIKE 906
+ L D++ KK ++ K K + S + K+T L+ E+ +++
Sbjct: 78 VATALKLSQDDQTTIASLKK-EIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQ 136
Query: 907 LEMICQDEKSEKK--VRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSL 964
+ D+ S + +RF E KE D L S+ + +
Sbjct: 137 GSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHA 196
Query: 965 KDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE 1024
Q+ + R + + K +L+K ++ ++ ++ +K ++ K+K
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKAL----QQYVQKSK-- 250
Query: 1025 KEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLS 1084
+E+ ++ +L + + NE R E+ + + NAKL+ + + + + L EN +
Sbjct: 251 EELQKLEQQLK--EQKILNE--RAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKA 306
Query: 1085 NQCKTLTEEMKNREAQINKLS 1105
+ K EE+ I KL+
Sbjct: 307 LELKAKEEEVHQMRLDIGKLN 327
Score = 35.1 bits (77), Expect = 2.6
Identities = 43/204 (21%), Positives = 89/204 (43%), Gaps = 10/204 (4%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRR-LANIDTANKY-TTGRSSEV 319
V+ + + ++QI GL++EV+ +K+ E K ++L R + N + T + +++
Sbjct: 347 VEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDL 406
Query: 320 LKL-QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAE 378
+KL +Q L ++ +DE QK R+I LE + Q L K+L
Sbjct: 407 VKLHEQAKRNLEGEIQNYKDE----AQKQRKIIFHLE--KERDRYINQASDLTQKVLMNM 460
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ + D +K++ + Q N E + + + L + + KL
Sbjct: 461 EDIKVRETQIFDYRKKIAE-SEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKL 519
Query: 439 KKTERKADQLEQEKAEHEKKLLEI 462
K + D+L+++ + E L+++
Sbjct: 520 KIMIHQVDELKEDISAKESALVKL 543
>BC126123-1|AAI26124.1| 1093|Homo sapiens TATA element modulatory
factor 1 protein.
Length = 1093
Score = 64.9 bits (151), Expect = 3e-09
Identities = 126/659 (19%), Positives = 258/659 (39%), Gaps = 51/659 (7%)
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
++ L +++ + L L +E A F + +V + + S SSL +Q
Sbjct: 451 VEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS---SISSLKDEFTQRI 507
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET 594
A+ + +Q + + +++++N +EE A ++N D D + + E E
Sbjct: 508 -AEAEKKVQLACKERDAAKKEIKNIKEELAT--RLNSSETADLLKEKDEQIRGLMEEGEK 564
Query: 595 VTNS-IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFD-----LPYLSIFNHMAAN 648
++ + N I KE +++ ++K +E + L
Sbjct: 565 LSKQQLHNSNIIKKLRAKDKE-NENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRE 623
Query: 649 NLRKTAARVEEDNESL-LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP 707
N++K + VE + L LQ+ + ++R + + + + + + EA
Sbjct: 624 NIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQE 683
Query: 708 AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSL 767
A + ++ E+ + L + EE Q +E L QV +L + + +A R +
Sbjct: 684 AALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEI 743
Query: 768 TTNSNKL--AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
+L AE R + L + + L+ R E L A L + L K+ S
Sbjct: 744 GELQQRLQEAENRNQELSQSVSSTTRPLL---RQIENLQATLGSQTSSWEKLEKNLSDRL 800
Query: 826 SDQQNV---DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA 882
+ Q + ++R+ E E + + S+E+ N L+ EN + Q ++ R K
Sbjct: 801 GESQTLLAAAVERERAATE-ELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKL 859
Query: 883 LDLNTKKTTQLENELKEALAKIKE-----------LEM-ICQDEKSEKKVRFTEATKKET 930
D N + +LEN E + ++E LEM + E+ KK FT+ T KE
Sbjct: 860 EDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEK 919
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR-IPKKPTDLTTKLQL 989
+ Q + S + SF P I ++L +++
Sbjct: 920 ERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRM 979
Query: 990 ---KKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKN 1046
++E+L+ ++ L E+T +++ RS +++ + TN+ +
Sbjct: 980 GAGSSIIENLQSQL----------KLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQND 1029
Query: 1047 RLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNR-EAQINKL 1104
L+ ++ ++ + +L D D N + E + + + + E++KN + QI++L
Sbjct: 1030 ELEEKVKEIPKLRTQLR-DLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDEL 1087
Score = 45.2 bits (102), Expect = 0.002
Identities = 43/171 (25%), Positives = 77/171 (45%), Gaps = 5/171 (2%)
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL 1433
E K + + L S K+L + A+ K+ +A+ A L ++K E+ S A K E
Sbjct: 650 EEKNRSIQAALDSAYKELTDLHKANA--AKDSEAQEAALSREMKAKEELSAALEKAQEEA 707
Query: 1434 KQEYEETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQK 1492
+Q+ E ++ + LAL++ E + K + L E + RL + + Q V
Sbjct: 708 RQQQETLAIQVGDLRLALQRTE-QAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSS 766
Query: 1493 ELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA 1543
L +I+ LQ LG+++++W + + + + Q L E ERA
Sbjct: 767 TTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQ-TLLAAAVERERA 816
Score = 34.3 bits (75), Expect = 4.5
Identities = 48/201 (23%), Positives = 88/201 (43%), Gaps = 18/201 (8%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL-KQE 1436
+E++ + KKL+ M +KD+ ++ L+ K + ++ + K +T+L K
Sbjct: 615 EEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKAN 674
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEH---------VVTKARLTVEK-EQA--- 1483
+ + E +L+ E EEL+ E +EE V RL +++ EQA
Sbjct: 675 AAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAAR 734
Query: 1484 -QGELLHVQKELSTALGEIKTLQEKLG-TESAAWNTEKTEMQNSIASLQERLCGGGWEVE 1541
+ L H EL L E + ++L + S+ +++N A+L + WE
Sbjct: 735 KEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQT--SSWEKL 792
Query: 1542 RARLNARLDQRERELRAANDR 1562
L+ RL + + L AA +R
Sbjct: 793 EKNLSDRLGESQTLLAAAVER 813
>BC117418-1|AAI17419.1| 1093|Homo sapiens TATA element modulatory
factor 1 protein.
Length = 1093
Score = 64.9 bits (151), Expect = 3e-09
Identities = 126/659 (19%), Positives = 258/659 (39%), Gaps = 51/659 (7%)
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
++ L +++ + L L +E A F + +V + + S SSL +Q
Sbjct: 451 VEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS---SISSLKDEFTQRI 507
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET 594
A+ + +Q + + +++++N +EE A ++N D D + + E E
Sbjct: 508 -AEAEKKVQLACKERDAAKKEIKNIKEELAT--RLNSSETADLLKEKDEQIRGLMEEGEK 564
Query: 595 VTNS-IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFD-----LPYLSIFNHMAAN 648
++ + N I KE +++ ++K +E + L
Sbjct: 565 LSKQQLHNSNIIKKLRAKDKE-NENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRE 623
Query: 649 NLRKTAARVEEDNESL-LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP 707
N++K + VE + L LQ+ + ++R + + + + + + EA
Sbjct: 624 NIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQE 683
Query: 708 AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSL 767
A + ++ E+ + L + EE Q +E L QV +L + + +A R +
Sbjct: 684 AALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEI 743
Query: 768 TTNSNKL--AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
+L AE R + L + + L+ R E L A L + L K+ S
Sbjct: 744 GELQQRLQEAENRNQELSQSVSSTTRPLL---RQIENLQATLGSQTSSWEKLEKNLSDRL 800
Query: 826 SDQQNV---DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA 882
+ Q + ++R+ E E + + S+E+ N L+ EN + Q ++ R K
Sbjct: 801 GESQTLLAAAVERERAATE-ELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKL 859
Query: 883 LDLNTKKTTQLENELKEALAKIKE-----------LEM-ICQDEKSEKKVRFTEATKKET 930
D N + +LEN E + ++E LEM + E+ KK FT+ T KE
Sbjct: 860 EDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEK 919
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR-IPKKPTDLTTKLQL 989
+ Q + S + SF P I ++L +++
Sbjct: 920 ERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRM 979
Query: 990 ---KKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKN 1046
++E+L+ ++ L E+T +++ RS +++ + TN+ +
Sbjct: 980 GAGSSIIENLQSQL----------KLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQND 1029
Query: 1047 RLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNR-EAQINKL 1104
L+ ++ ++ + +L D D N + E + + + + E++KN + QI++L
Sbjct: 1030 ELEEKVKEIPKLRTQLR-DLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDEL 1087
Score = 45.2 bits (102), Expect = 0.002
Identities = 43/171 (25%), Positives = 77/171 (45%), Gaps = 5/171 (2%)
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL 1433
E K + + L S K+L + A+ K+ +A+ A L ++K E+ S A K E
Sbjct: 650 EEKNRSIQAALDSAYKELTDLHKANA--AKDSEAQEAALSREMKAKEELSAALEKAQEEA 707
Query: 1434 KQEYEETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQK 1492
+Q+ E ++ + LAL++ E + K + L E + RL + + Q V
Sbjct: 708 RQQQETLAIQVGDLRLALQRTE-QAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSS 766
Query: 1493 ELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA 1543
L +I+ LQ LG+++++W + + + + Q L E ERA
Sbjct: 767 TTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQ-TLLAAAVERERA 816
Score = 34.3 bits (75), Expect = 4.5
Identities = 48/201 (23%), Positives = 88/201 (43%), Gaps = 18/201 (8%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL-KQE 1436
+E++ + KKL+ M +KD+ ++ L+ K + ++ + K +T+L K
Sbjct: 615 EEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKAN 674
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEH---------VVTKARLTVEK-EQA--- 1483
+ + E +L+ E EEL+ E +EE V RL +++ EQA
Sbjct: 675 AAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAAR 734
Query: 1484 -QGELLHVQKELSTALGEIKTLQEKLG-TESAAWNTEKTEMQNSIASLQERLCGGGWEVE 1541
+ L H EL L E + ++L + S+ +++N A+L + WE
Sbjct: 735 KEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQT--SSWEKL 792
Query: 1542 RARLNARLDQRERELRAANDR 1562
L+ RL + + L AA +R
Sbjct: 793 EKNLSDRLGESQTLLAAAVER 813
>AK025632-1|BAB15196.1| 720|Homo sapiens protein ( Homo sapiens
cDNA: FLJ21979 fis, clone HEP06065. ).
Length = 720
Score = 64.9 bits (151), Expect = 3e-09
Identities = 138/662 (20%), Positives = 280/662 (42%), Gaps = 71/662 (10%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSE-VLKLQQ 324
+K ++QI+ +E++IL K ++E + SD L + + A + G + ++ L +
Sbjct: 100 IKNCKNQIKIRDREIEILTKEINKLELKISDFL-----DENEALRERVGLEPKTMIDLTE 154
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEEL 384
N + R E + L ++EIES E R + + RQ+ Q R K A L E
Sbjct: 155 FRNSKHLKQQQYRAENQIL---LKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTED 211
Query: 385 MDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
++ E++ + D E + D SL+ E KN LS +L + ER
Sbjct: 212 LNLTENISQG------------DRISERKLD-LLSLKNMSEAQSKN-EFLSRELIEKERD 257
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
++ A+ + KL E+V EN K+LE+ + + +Q++
Sbjct: 258 LERSRTVIAKFQNKLKELV-------EEN--KQLEEGMKEILQAIKEMQKD-----PDVK 303
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETA 564
G SL+ +P E + + S G + L + R +LR++LR + +E
Sbjct: 304 GGETSLI-IPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAI 362
Query: 565 NCKQ-----------VNPPTFLDKQVMTDNIVTCDIH-------ESETVTNSIQNKMIHA 606
N Q + T L +Q N+V I S ++ NS +IH
Sbjct: 363 NYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHL 422
Query: 607 ASTPSSKEKS-DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAAR-VEEDNESL 664
+KEK + S++ + L +++ KT ++ ++E+ L
Sbjct: 423 LQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKL 482
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVL 724
Q+++ A K + N L D+DE + A+ + +L++NE+ +++
Sbjct: 483 EDQVQQDAIKVKE--------YNNLLNALQMDSDEMKKILAENSRKITVLQVNEK--SLI 532
Query: 725 RRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLED 784
R+ +E +++ L+K+ ++ +++ S+ +R K+A + KV+++
Sbjct: 533 RQYTTLVELERQ-LRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQ-KVVDN 590
Query: 785 EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEA 844
+ +L K+ + E + QK + ++ +L+ + +N+ LK Q++ I +E
Sbjct: 591 SVSLSELELANKQYN-ELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKEL 649
Query: 845 SVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKI 904
+ + K ++E E+ + + K KS+ + + ++ KK + + + K+ K
Sbjct: 650 EITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKKKKKKKKKKKKKKKKK 709
Query: 905 KE 906
K+
Sbjct: 710 KK 711
Score = 54.4 bits (125), Expect = 4e-06
Identities = 73/306 (23%), Positives = 144/306 (47%), Gaps = 40/306 (13%)
Query: 662 ESLLLQLK--KMATKARSRKLSP-TPPANKLSIETANDNDEKET-DEADPAEMKLLLELN 717
E ++++K K K R R++ T NKL ++ ++ DE E E E K +++L
Sbjct: 94 EDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLT 153
Query: 718 E-------------QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
E E +L +++E LE+++ LKK+++++ + + TS TT
Sbjct: 154 EFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG--LTTED 211
Query: 765 RSLTTN---SNKLAEERVKVLE-DEIDEVRKK-------LIEKERDCERLHAELSLAQKK 813
+LT N ++++E ++ +L + E + K LIEKERD ER ++ Q K
Sbjct: 212 LNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNK 271
Query: 814 PKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL--QTENKKLQLL 871
K L++ ++ ++ + ++ ++++ V +T + E+L E+K + +
Sbjct: 272 LKELVEENK--QLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGI 329
Query: 872 KNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
+A SL +D T + +L EL+E ++ + + Q K+ K+ E KET
Sbjct: 330 FDA-SLHLKAQVDQLTGRNEELRQELRE--SRKEAINYSQQLAKANLKIDHLE---KETS 383
Query: 932 TLKSKQ 937
L+ +
Sbjct: 384 LLRQSE 389
Score = 39.9 bits (89), Expect = 0.091
Identities = 45/208 (21%), Positives = 96/208 (46%), Gaps = 20/208 (9%)
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKA 1377
+D++ IK+++ +A +++ ++K LA EN Y
Sbjct: 483 EDQVQQDAIKVKEYNNLLNALQMDSDEMKKILA--ENSRKITVLQVNEKSLIRQY--TTL 538
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEY 1437
EL+ L+ E +K ++ + +AE+ K+ L++ +I L++
Sbjct: 539 VELERQLRKENEK-------QKNELLSMEAEVCE---KIGCLQRFKEMAIFKIAALQKVV 588
Query: 1438 EETVKKLEHSLALEKAEYEELTGKY-ELLEEEHVVTKARLTVEKEQAQGELLHVQKELST 1496
+ +V E L L +Y ELT KY ++L++++++ + T E + E + +++++ +
Sbjct: 589 DNSVSLSE--LELANKQYNELTAKYRDILQKDNMLVQR--TSNLEHLECENISLKEQVES 644
Query: 1497 ALGEIKTLQEKLGTESAAWNTEKTEMQN 1524
E++ +EKL T AW E T++ N
Sbjct: 645 INKELEITKEKLHTIEQAWEQE-TKLGN 671
>AB209109-1|BAD92346.1| 1096|Homo sapiens TATA element modulatory
factor 1 variant protein.
Length = 1096
Score = 64.9 bits (151), Expect = 3e-09
Identities = 126/659 (19%), Positives = 258/659 (39%), Gaps = 51/659 (7%)
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
++ L +++ + L L +E A F + +V + + S SSL +Q
Sbjct: 454 VEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS---SISSLKDEFTQRI 510
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET 594
A+ + +Q + + +++++N +EE A ++N D D + + E E
Sbjct: 511 -AEAEKKVQLACKERDAAKKEIKNIKEELAT--RLNSSETADLLKEKDEQIRGLMEEGEK 567
Query: 595 VTNS-IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFD-----LPYLSIFNHMAAN 648
++ + N I KE +++ ++K +E + L
Sbjct: 568 LSKQQLHNSNIIKKLRAKDKE-NENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRE 626
Query: 649 NLRKTAARVEEDNESL-LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP 707
N++K + VE + L LQ+ + ++R + + + + + + EA
Sbjct: 627 NIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQE 686
Query: 708 AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSL 767
A + ++ E+ + L + EE Q +E L QV +L + + +A R +
Sbjct: 687 AALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEI 746
Query: 768 TTNSNKL--AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
+L AE R + L + + L+ R E L A L + L K+ S
Sbjct: 747 GELQQRLQEAENRNQELSQSVSSTTRPLL---RQIENLQATLGSQTSSWEKLEKNLSDRL 803
Query: 826 SDQQNV---DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA 882
+ Q + ++R+ E E + + S+E+ N L+ EN + Q ++ R K
Sbjct: 804 GESQTLLAAAVERERAATE-ELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKL 862
Query: 883 LDLNTKKTTQLENELKEALAKIKE-----------LEM-ICQDEKSEKKVRFTEATKKET 930
D N + +LEN E + ++E LEM + E+ KK FT+ T KE
Sbjct: 863 EDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEK 922
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPR-IPKKPTDLTTKLQL 989
+ Q + S + SF P I ++L +++
Sbjct: 923 ERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRM 982
Query: 990 ---KKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKN 1046
++E+L+ ++ L E+T +++ RS +++ + TN+ +
Sbjct: 983 GAGSSIIENLQSQL----------KLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQND 1032
Query: 1047 RLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNR-EAQINKL 1104
L+ ++ ++ + +L D D N + E + + + + E++KN + QI++L
Sbjct: 1033 ELEEKVKEIPKLRTQLR-DLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDEL 1090
Score = 45.2 bits (102), Expect = 0.002
Identities = 43/171 (25%), Positives = 77/171 (45%), Gaps = 5/171 (2%)
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL 1433
E K + + L S K+L + A+ K+ +A+ A L ++K E+ S A K E
Sbjct: 653 EEKNRSIQAALDSAYKELTDLHKANA--AKDSEAQEAALSREMKAKEELSAALEKAQEEA 710
Query: 1434 KQEYEETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQK 1492
+Q+ E ++ + LAL++ E + K + L E + RL + + Q V
Sbjct: 711 RQQQETLAIQVGDLRLALQRTE-QAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSS 769
Query: 1493 ELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA 1543
L +I+ LQ LG+++++W + + + + Q L E ERA
Sbjct: 770 TTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQ-TLLAAAVERERA 819
Score = 34.3 bits (75), Expect = 4.5
Identities = 48/201 (23%), Positives = 88/201 (43%), Gaps = 18/201 (8%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL-KQE 1436
+E++ + KKL+ M +KD+ ++ L+ K + ++ + K +T+L K
Sbjct: 618 EEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKAN 677
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEH---------VVTKARLTVEK-EQA--- 1483
+ + E +L+ E EEL+ E +EE V RL +++ EQA
Sbjct: 678 AAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAAR 737
Query: 1484 -QGELLHVQKELSTALGEIKTLQEKLG-TESAAWNTEKTEMQNSIASLQERLCGGGWEVE 1541
+ L H EL L E + ++L + S+ +++N A+L + WE
Sbjct: 738 KEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQT--SSWEKL 795
Query: 1542 RARLNARLDQRERELRAANDR 1562
L+ RL + + L AA +R
Sbjct: 796 EKNLSDRLGESQTLLAAAVER 816
>M25139-1|AAA60385.1| 611|Homo sapiens myosin heavy chain
beta-subunit protein.
Length = 611
Score = 64.5 bits (150), Expect = 4e-09
Identities = 100/556 (17%), Positives = 225/556 (40%), Gaps = 51/556 (9%)
Query: 532 QEDPAQLLRDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIH 590
+ D Q +L+++ ++ A L+E E A C + + + D +V D+
Sbjct: 52 ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMV--DVE 109
Query: 591 ESETVTNSIQNKMIHAASTPSS-KEKSDSPPLSIDKTTEETQ------FHFDLPYLSIFN 643
S ++ K + + K+K + ++ + +E + F Y
Sbjct: 110 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 169
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMA-TKARSRKLSPTPPANKLSIETANDNDEKET 702
H+ ++ ++E+ L QL T K+ A K+ +++A + E
Sbjct: 170 HL--ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL 227
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
+ + ++ LE N+ +A + R+ E+ E+ ++A + ++ + S +TS + T
Sbjct: 228 EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS-----LQTSLDAETR 282
Query: 763 ARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
+R K+ E +++E+ +L R+ AE K ++L+K
Sbjct: 283 SRNEALRVKKKM--------EGDLNEMEIQLSH----ANRMAAEAQKQVKSLQSLLKDTQ 330
Query: 823 LDASD--QQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENK-----KLQLLKNAK 875
+ D + N DLK + ++E+ ++L+A+ + L A E+ + K ++ + +
Sbjct: 331 IQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADRELIETSERVQ 390
Query: 876 SLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
L S +N KK +++ +L + +++E C++ + + K T+A + LK
Sbjct: 391 LLHSQNTSLINQKK--KMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-AEELKK 447
Query: 936 KQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVED 995
+Q Q L + A K K ++ K + +L+ +E
Sbjct: 448 EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR---ELENELEA 504
Query: 996 LECEIGEMYVVMKNAGLSGKEMTAKT--------KLEKEIDEIRSKLSKNDSEFTNEKNR 1047
+ E M+ + KE+T +T +L+ +D+++ K+ + + +
Sbjct: 505 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 564
Query: 1048 LQTEIAKLKDVNAKLE 1063
T ++K + V +L+
Sbjct: 565 ANTNLSKFRKVQHELD 580
Score = 46.0 bits (104), Expect = 0.001
Identities = 66/292 (22%), Positives = 113/292 (38%), Gaps = 19/292 (6%)
Query: 284 RKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL 343
R RV+K+ L + AN+ +V LQ + + +D L
Sbjct: 284 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 343
Query: 344 TQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXX 403
+ I +E R + Q ++E+LRA + E +L D E L
Sbjct: 344 KENIAIVE-----RRNNLLQA-ELEELRAVVEQTER-SRKLADRELIETSERVQLLHSQN 396
Query: 404 XMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
N ++ + S L+ E+E+ ++ CR K KK A + +E + + +
Sbjct: 397 TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 456
Query: 464 GGPDGMQRENRIKELEQEVARSTEVAL---RLQRELAEANSKFTGSNPSLMKVPQPETVK 520
M E IK+L+ + + ++AL + Q + EA + + + E+VK
Sbjct: 457 RMKKNM--EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVK 514
Query: 521 VSRSSLTR-----GGSQEDPAQLLR--DLQDSLEREADLREQLRNAEEETAN 565
R S R ++ED LLR DL D L+ + ++ EE AN
Sbjct: 515 GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN 566
Score = 44.8 bits (101), Expect = 0.003
Identities = 66/317 (20%), Positives = 132/317 (41%), Gaps = 28/317 (8%)
Query: 1214 VLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRD---LKADYENKITSLESTIA 1270
V+ + L E S + L+ + K E +E ++ + A+ + ++ SL+S +
Sbjct: 269 VVDSLQTSLDAETRSRNEALRVKK-KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL- 326
Query: 1271 AKDVHIKQLEDALRQTTNDKYDEATSP-------VEMVEMRXXXXXXXXXXXXXQDELNN 1323
KD I QL+DA+R + K + A E+ E+R EL
Sbjct: 327 -KDTQI-QLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLADRELIE 384
Query: 1324 AKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXX--------XXXXXXXXSSYWEN 1375
+++ +++++ + ++ +DL++L+ + E
Sbjct: 385 TSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 444
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
KE DT ER K + + D + +AE LKG K L++ + EL+
Sbjct: 445 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 504
Query: 1436 EYE---ETVKKLEHS-LALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQ 1491
E + E+VK + S +++ Y+ + LL + +V K +L V+ + Q E +
Sbjct: 505 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAE--EAE 562
Query: 1492 KELSTALGEIKTLQEKL 1508
++ +T L + + +Q +L
Sbjct: 563 EQANTNLSKFRKVQHEL 579
Score = 40.7 bits (91), Expect = 0.052
Identities = 84/458 (18%), Positives = 188/458 (41%), Gaps = 46/458 (10%)
Query: 1376 KAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+A+E + ++ L++ + ++++ ++ L++ K + E KQ
Sbjct: 75 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 134
Query: 1436 EYEETVKKLEHSLALEKAEYEELTGKYELLEE--EHVVTKARLTVEKEQAQGELLHVQKE 1493
+YEE+ +LE S ++ EL EE EH+ T R E + Q E+ + ++
Sbjct: 135 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR---ENKNLQEEISDLTEQ 191
Query: 1494 LSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARL--NARLDQ 1551
L ++ I L EK+ + A EK E+Q+++ + L ++ RA+L N +
Sbjct: 192 LGSSGKTIHEL-EKVRKQLEA---EKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 247
Query: 1552 RERELRAANDRRDVLEHHH----DXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXX 1607
ER+L ++ + + +H D + RV K
Sbjct: 248 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 307
Query: 1608 XXXXXXXIEQSEKARKAEITDTKTR-----------------YEGQMNTMRDELKSLHNQ 1650
++ K+ ++ + DT+ + E + N ++ EL+ L
Sbjct: 308 ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAV 367
Query: 1651 VSRFRRERD-NYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVA 1709
V + R R ++++E +++ ++ + ++ I++ D + + +V Q+
Sbjct: 368 VEQTERSRKLADRELIETSER--VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR 425
Query: 1710 CLEDE----LCESRLLASKLNTE------LVSEKSSAEVRLAEMQSRLNEYEEERLLSSG 1759
E++ + ++ ++A +L E L K + E + ++Q RL+E E+ L G
Sbjct: 426 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE-AEQIALKGG 484
Query: 1760 RARVAGLATRMELAWHKERDEQQRLLQETSTLARDLRQ 1797
+ ++ L R+ ++ EQ+R + + + R+
Sbjct: 485 KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERR 522
Score = 40.3 bits (90), Expect = 0.069
Identities = 104/574 (18%), Positives = 213/574 (37%), Gaps = 50/574 (8%)
Query: 1029 EIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCK 1088
E++ LSK +SE + + +T+ + + +LE K A + + E ++ +C
Sbjct: 32 ELQRVLSKANSEVAQWRTKYETDAIQRTE---ELEEAKKKLAQRLQEAEEAVEAVNAKCS 88
Query: 1089 TLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXXXQVDN 1148
+L + + +I L D++ + + + ++
Sbjct: 89 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE---------ES 139
Query: 1149 YTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXXXXXXX 1208
++++ + K + + + K+ + KR K L +T
Sbjct: 140 QSELESSQ-KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKT 198
Query: 1209 XXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLEST 1268
+ + +EL S +E +A E K + + E +KA+ E K+ +
Sbjct: 199 IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEE 258
Query: 1269 I-AAKDVHIK---QLEDALRQTTNDKYDEATSPVEMV----EMRXXXXXXXXXXXXXQDE 1320
+ AK H++ L+ +L T + + +M EM Q +
Sbjct: 259 MEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQ 318
Query: 1321 LNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKEL 1380
+ + + L+ T+ + A LK ++A +E E K
Sbjct: 319 VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA 378
Query: 1381 DTDL--QSER-KKLDRMRIAHDKDVKNKDAELATLKGKLKILEQ---NSGAGAKR-ITEL 1433
D +L SER + L + K DA+L+ L+ +++ Q N+ AK+ IT+
Sbjct: 379 DRELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDA 438
Query: 1434 KQEYEETVKKLEHSLALEKAEYE-ELTGK---YELLEEEHVVTKA------RLTVEKEQA 1483
EE K+ + S LE+ + E T K + L E E + K +L +
Sbjct: 439 AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL 498
Query: 1484 QGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEK-----TEMQNSIASLQERLCGGGW 1538
+ EL QK + ++ ++ + ++ + + TE+ +Q+ + LQ ++
Sbjct: 499 ENELEAEQKRNAESVKGMRKSERRI--KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKR 556
Query: 1539 EVERARLNA-----RLDQRERELRAANDRRDVLE 1567
+ E A A + + + EL A +R D+ E
Sbjct: 557 QAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 590
>L01042-1|AAD54608.1| 1093|Homo sapiens TATA element modulatory factor
protein.
Length = 1093
Score = 64.5 bits (150), Expect = 4e-09
Identities = 127/655 (19%), Positives = 251/655 (38%), Gaps = 43/655 (6%)
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
++ L +++ + L L +E A F + +V + + S SSL +Q
Sbjct: 451 VEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESS---SISSLKDEFTQRI 507
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESET 594
A+ + +Q + + +++++N +EE A ++N D D + + E E
Sbjct: 508 -AEAEKKVQLACKERDAAKKEIKNIKEELAT--RLNSSETADLLKEKDEQIRGLMEEGEK 564
Query: 595 VTNS-IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFD-----LPYLSIFNHMAAN 648
++ + N I KE +++ ++K +E + L
Sbjct: 565 LSKQQLHNSNIIKKLRAKDKE-NENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRE 623
Query: 649 NLRKTAARVEEDNESL-LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP 707
N++K + VE + L LQ+ + ++R + + + + + + EA
Sbjct: 624 NIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQE 683
Query: 708 AEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSL 767
A + ++ E+ + L + EE Q +E L QV +L + + +A R +
Sbjct: 684 AALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEI 743
Query: 768 TTNSNKL--AEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDA 825
+L AE R + L + + L+ R E L A L + L K+ S
Sbjct: 744 GELQQRLQEAENRNQELSQSVSSTTRPLL---RQIENLQATLGSQTSSWEKLEKNLSDRL 800
Query: 826 SDQQNV---DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKA 882
+ Q + ++R+ E E + + S+E+ N L+ EN + Q ++ R K
Sbjct: 801 GESQTLLAAAVERERAATE-ELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCKL 859
Query: 883 LDLNTKKTTQLENELKEALAKIKE-----------LEM-ICQDEKSEKKVRFTEATKKET 930
D N + +LEN E + ++E LEM + E+ KK FT+ T KE
Sbjct: 860 EDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEK 919
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK 990
+ Q + S + SF P P K L
Sbjct: 920 ERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHSFGP----MPISAKWK-HLY 974
Query: 991 KMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQT 1050
+D I + + L E+T +++ RS +++ + TN+ + L+
Sbjct: 975 AACKD-GSRIKHIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEE 1033
Query: 1051 EIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNR-EAQINKL 1104
++ ++ + +L D D N + E + + + + E++KN + QI++L
Sbjct: 1034 KVKEIPKLRTQLR-DLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMYKTQIDEL 1087
Score = 53.6 bits (123), Expect = 7e-06
Identities = 104/548 (18%), Positives = 212/548 (38%), Gaps = 43/548 (7%)
Query: 767 LTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ---KKPKTLIKSRSL 823
+ NS+ + V+ E + +EV + L+ + E + S ++P L+ S +
Sbjct: 358 IIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPI 417
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKT---QSLEADNEKLQTENKKLQLLKNAKSLRSD 880
+ + Q + E + L K +++E NEKL+ +L L K+L +
Sbjct: 418 NEGQTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALL-E 476
Query: 881 KALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFT----EATKKETDTLKSK 936
+A D N K E +++ +K+ E + ++EKKV+ +A KKE +K +
Sbjct: 477 EAFD-NLKDEMFRVKEESSSISSLKD-EFTQRIAEAEKKVQLACKERDAAKKEIKNIKEE 534
Query: 937 QXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLK-KMVED 995
++ L ++ +K K ++ +++ KL+ K K E+
Sbjct: 535 ----LATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHN--SNIIKKLRAKDKENEN 588
Query: 996 LECEIGEMYVVMKNAGLSGKE-MTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAK 1054
+ ++ + ++ K+ + K ++EK+ E KL+ + RLQ ++ +
Sbjct: 589 MVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDE 648
Query: 1055 LKDVNAKLEGDKDVFANKYKALENENSNLSNQCK--TLTEEMKNREAQINKLSADLKNAT 1112
L++ N ++ D + L N+ ++ + L+ EMK +E L + A
Sbjct: 649 LEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEAR 708
Query: 1113 SLQTTMS----DCMXXXXXXXXXXXXXXXXXXXXXXQVDNYTKIDQDKNKLLKEVGDKT- 1167
Q T++ D ++ + +++N+ L + T
Sbjct: 709 QQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTT 768
Query: 1168 ----KKIGDXXXXXXXXXXXCKRIEKQLSTR--KDRVTXXXXXXXXXXXQAVVLANTHRR 1221
++I + +++EK LS R + + +LAN +
Sbjct: 769 RPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQM 828
Query: 1222 LSIE-----LTSEKDELQARFIKTESKFITLEAEMRDLKADYEN----KITSLESTIAAK 1272
S+E L E QA+ +++ LE E + + EN + +LE T K
Sbjct: 829 SSMESQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEK 888
Query: 1273 DVHIKQLE 1280
+ QLE
Sbjct: 889 TLLNSQLE 896
Score = 45.2 bits (102), Expect = 0.002
Identities = 120/582 (20%), Positives = 230/582 (39%), Gaps = 61/582 (10%)
Query: 494 RELAEANS--KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREAD 551
R ++E NS + +G +L+ + + S++ + G E+ + L + EA+
Sbjct: 337 RSVSEINSDDELSGKGYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTE----EAE 392
Query: 552 LREQLRNAEEETANCKQ----VNPPTFLDKQVMTDNIVT-CDIHESETVTNSIQNKMIHA 606
+ E R+A NC+Q V+ + Q + D + C+ ES+ S + +
Sbjct: 393 MEESGRSATP--VNCEQPDILVSSTPINEGQTVLDKVAEQCEPAESQPEALSEKEDVCKT 450
Query: 607 ASTPSSK-EKSDSPPLSIDKTTEETQFHFDLPYLSIFN----HMAANNLR-KTAARVEED 660
+ K EK ++ LS+ K + FD +F + ++L+ + R+ E
Sbjct: 451 VEFLNEKLEKREAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEA 510
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKL-SIETAN---DNDEKETDEADPAEMKLLLEL 716
+ + L K+ + K A +L S ETA+ + DE+ + E +L
Sbjct: 511 EKKVQLACKERDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQL 570
Query: 717 -NEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
N LR K +E E L K+VKEL ++ + + G ++ N KL
Sbjct: 571 HNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQH-RENIKKL- 628
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
V+ E ++ ++ + E E + A L A K+ L K+ + S+ Q L R
Sbjct: 629 NSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSR 688
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+++ E+ ++ L + E L + L+L R+++A +K L +
Sbjct: 689 EMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQ----RTEQAA---ARKEDYLRH 741
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXX 955
E+ E +++E E Q E S+ T ++ + L++
Sbjct: 742 EIGELQQRLQEAENRNQ-ELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRL 800
Query: 956 XXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGK 1015
TL + + +++ + L K+Q+ M +N+ L +
Sbjct: 801 GESQTLLAAAVERERAATEEL------LANKIQMSSMES-------------QNSLLRQE 841
Query: 1016 EMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
+ +LE E +++L K + +E NR Q E+ LKD
Sbjct: 842 NSRFQAQLESE----KNRLCKLE----DENNRYQVELENLKD 875
Score = 45.2 bits (102), Expect = 0.002
Identities = 43/171 (25%), Positives = 77/171 (45%), Gaps = 5/171 (2%)
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL 1433
E K + + L S K+L + A+ K+ +A+ A L ++K E+ S A K E
Sbjct: 650 EEKNRSIQAALDSAYKELTDLHKANA--AKDSEAQEAALSREMKAKEELSAALEKAQEEA 707
Query: 1434 KQEYEETVKKL-EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQK 1492
+Q+ E ++ + LAL++ E + K + L E + RL + + Q V
Sbjct: 708 RQQQETLAIQVGDLRLALQRTE-QAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSS 766
Query: 1493 ELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA 1543
L +I+ LQ LG+++++W + + + + Q L E ERA
Sbjct: 767 TTRPLLRQIENLQATLGSQTSSWEKLEKNLSDRLGESQ-TLLAAAVERERA 816
Score = 34.3 bits (75), Expect = 4.5
Identities = 48/201 (23%), Positives = 88/201 (43%), Gaps = 18/201 (8%)
Query: 1378 KELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL-KQE 1436
+E++ + KKL+ M +KD+ ++ L+ K + ++ + K +T+L K
Sbjct: 615 EEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKAN 674
Query: 1437 YEETVKKLEHSLALEKAEYEELTGKYELLEEEH---------VVTKARLTVEK-EQA--- 1483
+ + E +L+ E EEL+ E +EE V RL +++ EQA
Sbjct: 675 AAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAAR 734
Query: 1484 -QGELLHVQKELSTALGEIKTLQEKLG-TESAAWNTEKTEMQNSIASLQERLCGGGWEVE 1541
+ L H EL L E + ++L + S+ +++N A+L + WE
Sbjct: 735 KEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQT--SSWEKL 792
Query: 1542 RARLNARLDQRERELRAANDR 1562
L+ RL + + L AA +R
Sbjct: 793 EKNLSDRLGESQTLLAAAVER 813
>DQ139275-1|ABA43896.1| 1313|Homo sapiens Tax1-binding protein 2
protein.
Length = 1313
Score = 64.5 bits (150), Expect = 4e-09
Identities = 130/638 (20%), Positives = 264/638 (41%), Gaps = 50/638 (7%)
Query: 288 ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKI 347
E + ++K D L R +A ++ GR + + E E+LR E++ Q +
Sbjct: 49 ESLAQDKLD-LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGL 107
Query: 348 R-EIESELETRPSTEAQTRQIEQLRAKLLAA-ETLCEELMDENEDMKKELRDLXXXXXXM 405
+ + + + E Q + R++L L +L +++++ R+ +
Sbjct: 108 EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEAL 167
Query: 406 QDNFREDQA--DEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
+ RE +A E++ L +L + R LS + + + + LE E +++L ++
Sbjct: 168 ERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLE 227
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+ ++ E + L +E LR Q+ +A K+ Q E +
Sbjct: 228 ARREQLEAEGQALLLAKETLTGELAGLR-QQIIATQEKASLDKELMAQKLVQAEREAQAS 286
Query: 524 SSLTRGGSQEDPAQLLRDLQDS---LERE-ADLREQLRNAEEET-----ANCKQVNPPTF 574
R +ED +L R+ + + LE E A L+ QL+ +EE A ++++
Sbjct: 287 LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIA 346
Query: 575 LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHF 634
+Q + ++ + + + ++ K + ++ + L +++ + Q
Sbjct: 347 ALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQ 406
Query: 635 DLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS---RKLSPTPPANKLS- 690
+ ++ + + LR A+ EE + +++++ +AR ++ S A +L
Sbjct: 407 EQDRSTV--NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRT 464
Query: 691 ----IETANDNDEKETDEADPA--EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKE 744
+E A D +E EA E + E+ QEA LRR + E +++EAL++ +E
Sbjct: 465 QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEE 524
Query: 745 LTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDEIDEVRKKLIEKERDCER 802
L S + K + + + + KLA EE + E E+R L E ER R
Sbjct: 525 LRSAV----KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER--SR 578
Query: 803 LHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV-LRAKTQSLEADNEKL 861
L A L + + R + D +N L R+L ++ ++ RA+ +S +
Sbjct: 579 LEARRELQELR-------RQMKMLDSENTRLGRELAELQGRLALGERAEKES------RR 625
Query: 862 QTENKKLQLLKNAKSLR-SDKALDLNTKKTTQLENELK 898
+T + +LLK SL + L + +K + E E +
Sbjct: 626 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 663
Score = 50.8 bits (116), Expect = 5e-05
Identities = 94/495 (18%), Positives = 200/495 (40%), Gaps = 37/495 (7%)
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRI 475
E LR + + + + +A QL++ AE E+ + G G+Q E
Sbjct: 827 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAE--- 883
Query: 476 KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDP 535
L++E R +E R + + + S ++ Q K+S+ + D
Sbjct: 884 LALQEESVRRSERERRATLDQVATLERSLQATESELRASQE---KISKMKANETKLEGDK 940
Query: 536 AQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD--IHESE 593
+L L S R L Q R+ E E + Q + D + + + +SE
Sbjct: 941 RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1000
Query: 594 TVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAAN-NLRK 652
++Q + + E+S+ DK T+ S+ + N +L+K
Sbjct: 1001 VKAGTLQLTVERLNGALAKVEESEGALR--DKVRGLTEA-LAQSSASLNSTRDKNLHLQK 1057
Query: 653 TAARVEEDNESLLLQL---KKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE 709
E D + L +L ++ ++AR + S L E A+ ++ E +
Sbjct: 1058 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1117
Query: 710 MKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTT 769
++ +L ++ V++L+ ++ L++++ L ++ + +R +
Sbjct: 1118 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLE--------AEKREVER 1169
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQ 829
++ +L ++RV L +D+V ++ + D RL AE R+L ++ +
Sbjct: 1170 SALRLEKDRV-ALRRTLDKVEREKLRSHEDTVRLSAEKGRLD---------RTLTGAELE 1219
Query: 830 NVDLKRQLQVIEQEASVLRA--KTQSLEADNEKLQTE-NKKLQLLKNAKSLRSDKALDLN 886
+ +RQ+Q +E + VL LE D ++ Q E ++++ L++A++ ++++ L+
Sbjct: 1220 LAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQA-QTERTLEAR 1278
Query: 887 TKKTTQLENELKEAL 901
+ Q + LK L
Sbjct: 1279 ERAHRQRVSTLKGQL 1293
Score = 48.8 bits (111), Expect = 2e-04
Identities = 131/721 (18%), Positives = 269/721 (37%), Gaps = 45/721 (6%)
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L L A+ LQ KL L +SL DK LDLN + QLE E + ++
Sbjct: 23 LELSMTKLRAEEASLQDSLSKLSALN--ESLAQDK-LDLN-RLVAQLEEEKSALQGRQRQ 78
Query: 907 LEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD 966
E + E++ R E ++ + + + L++
Sbjct: 79 AEQEATVAREEQE-RLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQE 137
Query: 967 DAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMK-NAGLSGKEMTAKTKLEK 1025
+ + ++ + + ++ VE LE E + K +AGL+ ++ A + +
Sbjct: 138 QLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA-VQLVAAEREGR 196
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSN 1085
+ E ++L +Q ++A+L+ +LE + + L E + L
Sbjct: 197 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 256
Query: 1086 QCKTLTEEMK-NREAQINKL-SADLKNATSLQTTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
Q E+ ++E KL A+ + SL+ +
Sbjct: 257 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 316
Query: 1144 XQVDNYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEKQLSTRKDRVTXXXX 1203
Q+ + ++ +++ +LL + + +++ + + + S ++ ++
Sbjct: 317 AQLQS--QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE--SEKQQALSLKES 372
Query: 1204 XXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKIT 1263
+ + ++ +S+E+ +K + Q+R + S L +E+RDL+A
Sbjct: 373 EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA------- 425
Query: 1264 SLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNN 1323
E AA +++L++ R + D E E+R + EL
Sbjct: 426 QREEAAAAHAQEVRRLQEQARDLGKQR-DSCLREAE--ELRTQLRLLEDARDGLRRELLE 482
Query: 1324 AKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD 1383
A+ KL +++ + E +L+ L E S+ + +++ +
Sbjct: 483 AQRKLRESQEGREVQRQEAGELRRSLG--EGAKEREALRRSNEELRSAVKKAESERISLK 540
Query: 1384 LQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKK 1443
L +E K+ + + K+A L+ L+ +E++ + + EL+++ +K
Sbjct: 541 LANEDKEQKLALLEEARTAVGKEA--GELRTGLQEVERSRLEARRELQELRRQ----MKM 594
Query: 1444 LEHSLALEKAEYEELTGKYELLE-------EEHVVTKARL---TVEKEQAQGELLHVQKE 1493
L+ E EL G+ L E E + + RL E + EL Q++
Sbjct: 595 LDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK 654
Query: 1494 LSTALGEIKTLQEK-LGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQR 1552
L GE +T + + LG+ A TEK ++ ++ L+ +L E A L RL
Sbjct: 655 LQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA-RGLELKLEAA--RAEAAELGLRLSAA 711
Query: 1553 E 1553
E
Sbjct: 712 E 712
Score = 47.6 bits (108), Expect = 5e-04
Identities = 108/522 (20%), Positives = 220/522 (42%), Gaps = 53/522 (10%)
Query: 324 QKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEE 383
Q++ ++LR + L +++ E+E+E R S ++ RQ+++ A+ +E
Sbjct: 819 QELRSAQRERDELRTQTSALNRQLAEMEAE---RDSATSRARQLQKAVAE---SEEARRS 872
Query: 384 LMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ ++ EL L + R D+ ++L R L+ T R K+ K +
Sbjct: 873 VDGRLSGVQAELA-LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 931
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDG--MQRENRIKELEQEVARSTEVALRLQRELAEANS 501
+LE +K ++L E++ + ++ E + + LE E+ RS L L A+A +
Sbjct: 932 NETKLEGDK----RRLKEVLDASESRTVKLELQRRSLEGELQRS---RLGLSDREAQAQA 984
Query: 502 KFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
SL + +V+ S + G Q +L L E E LR+++R E
Sbjct: 985 -LQDRVDSLQR-------QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1036
Query: 562 ETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPL 621
A + + DK + +T H+ + + + + AA S+ + S L
Sbjct: 1037 ALAQ-SSASLNSTRDKNLHLQKALTACEHDRQ-----VLQERLDAARQALSEARKQSSSL 1090
Query: 622 SIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLS 681
T + DL + LR+ + +E + L ++K+ + R +
Sbjct: 1091 GEQVQTLRGEV-ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ-- 1147
Query: 682 PTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQ 741
S++ A E E E + + ++L E++ LRR ++++E++K +
Sbjct: 1148 ----ERLGSLQRALAQLEAEKREVERSALRL-----EKDRVALRRTLDKVEREKLRSHED 1198
Query: 742 VKELTSKISSVTKTSAGSN---TTARRSLTTNSNKLA--EERVKVLEDEIDEVRKKLIEK 796
L+++ + +T G+ A+R + ++ E+ + E+D +++L E
Sbjct: 1199 TVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL-EL 1257
Query: 797 ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQ 838
+++ ERL + AQ + + +++R A Q+ LK QLQ
Sbjct: 1258 QQEVERLRS----AQAQTERTLEARE-RAHRQRVSTLKGQLQ 1294
Score = 46.4 bits (105), Expect = 0.001
Identities = 96/425 (22%), Positives = 168/425 (39%), Gaps = 44/425 (10%)
Query: 704 EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVT------KTSA 757
+ DP ++ L QE +R+ +EL AL +Q+ E+ ++ S T + +
Sbjct: 804 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 863
Query: 758 GSNTTARRSLTTNSN------KLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ 811
+ ARRS+ + L EE V+ E E ++ ER + +EL +Q
Sbjct: 864 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 923
Query: 812 KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK----LQTENKK 867
+K + + + D++ LK L E L + +SLE + ++ L +
Sbjct: 924 EKISKMKANETKLEGDKRR--LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ 981
Query: 868 LQLLKNAKSLRSDKALDLNTKK-TTQLENE-LKEALAKIKELEMICQDEKSEKKVR-FTE 924
Q L++ + D K T QL E L ALAK++E E +D KVR TE
Sbjct: 982 AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD-----KVRGLTE 1036
Query: 925 ATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLT 984
A + + +L S + Q L DA + K+ + L
Sbjct: 1037 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL-----DAARQALSEARKQSSSLG 1091
Query: 985 TKLQ-LKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTN 1043
++Q L+ V DLE ++ G+ + L ++ E + + +
Sbjct: 1092 EQVQTLRGEVADLE---------LQRVEAEGQLQQLREVL-RQRQEGEAAALNTVQKLQD 1141
Query: 1044 EKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQC-KTLTEEMKNREAQIN 1102
E+ LQ + L+ A+LE +K LE + L K E++++ E +
Sbjct: 1142 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV- 1200
Query: 1103 KLSAD 1107
+LSA+
Sbjct: 1201 RLSAE 1205
Score = 46.0 bits (104), Expect = 0.001
Identities = 91/402 (22%), Positives = 159/402 (39%), Gaps = 28/402 (6%)
Query: 1408 ELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEE 1467
EL KL+ E + +++ L + + L +A + E L G+ E+
Sbjct: 22 ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQ 81
Query: 1468 EHVVTKARLTVEK-EQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSI 1526
E T AR E+ E+ + E ++ L +L + QE L + E++++Q +
Sbjct: 82 E--ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQL 139
Query: 1527 ASLQERLCGGGWEVERARLNARLDQRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXD 1586
A L +L G E+E+AR A+ Q E RAA ++ + + H
Sbjct: 140 AQLSRQLSGREQELEQARREAQ-RQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 198
Query: 1587 YERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKS 1646
E +++ R +E + +AE E T+ EL
Sbjct: 199 SEEATRL-RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE----TLTGELAG 253
Query: 1647 LHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVAL--- 1703
L Q+ + + K+++ AQK + + S R R + + R K A
Sbjct: 254 LRQQIIATQEKASLDKELM--AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRE 311
Query: 1704 LEQQVACLEDEL-CESRLLASKLNTEL--VSEKSSAEVRLAEMQSRLNEYEEERLLSSGR 1760
LE + A L+ +L E L ++L E +SE+ +A + + L E E+++ LS
Sbjct: 312 LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKE 371
Query: 1761 ARVAGLA-----TRMELAW------HKERDEQQRLLQETSTL 1791
+ L+ TR LA ++RD Q R Q+ ST+
Sbjct: 372 SEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTV 413
Score = 41.1 bits (92), Expect = 0.039
Identities = 68/279 (24%), Positives = 126/279 (45%), Gaps = 38/279 (13%)
Query: 1319 DELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAK 1378
D++ + L+ TE+E A++ +++++K++ KLE + E + +
Sbjct: 903 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 962
Query: 1379 ELDTDLQSERKKL-----------DRM----RIAHDKDVKNKDAELAT--LKGKLKILEQ 1421
L+ +LQ R L DR+ R D +VK +L L G L +E+
Sbjct: 963 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEE 1022
Query: 1422 NSGAGAKRITELKQEYEETVKKL----EHSLALEKA----EYEELTGKYELLEEEHVVTK 1473
+ GA ++ L + ++ L + +L L+KA E++ + L +++
Sbjct: 1023 SEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSE 1082
Query: 1474 AR-----LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT----ESAAWNTEKTEMQN 1524
AR L + + +GE+ ++ + A G+++ L+E L E+AA NT + ++Q+
Sbjct: 1083 ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQ-KLQD 1141
Query: 1525 SIASLQERLCGGGWEVERARLNARLDQRERE-LRAANDR 1562
LQERL G + A+L A + ER LR DR
Sbjct: 1142 ERRLLQERL--GSLQRALAQLEAEKREVERSALRLEKDR 1178
Score = 33.9 bits (74), Expect = 6.0
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 18/174 (10%)
Query: 1636 QMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSIS---ST 1692
+ + +R + +L+ Q++ ERD+ QK++AE + +S + + +
Sbjct: 827 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 886
Query: 1693 DEEEY----RNKVALLEQQVACLEDEL--CESRLLASKLNTELVSEKSSAEVRLAEMQSR 1746
EE R + A L+ QVA LE L ES L AS+ E +S+ + E +L + R
Sbjct: 887 QEESVRRSERERRATLD-QVATLERSLQATESELRASQ---EKISKMKANETKLEGDKRR 942
Query: 1747 LNEY---EEERL--LSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLARDL 1795
L E E R L R + G R L + Q L +L R +
Sbjct: 943 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 996
>BC000280-1|AAH00280.1| 471|Homo sapiens MYH10 protein protein.
Length = 471
Score = 64.5 bits (150), Expect = 4e-09
Identities = 57/282 (20%), Positives = 134/282 (47%), Gaps = 16/282 (5%)
Query: 832 DLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTT 891
+L++ + +EQ+ +R + + LE +E TE+ KL+L N +++++ DL T +
Sbjct: 24 ELEKSKRALEQQVEEMRTQLEELE--DELQATEDAKLRLEVNMQAMKAQFERDLQT-RDE 80
Query: 892 QLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXX 951
Q E + + + +++ELE +DE+ ++ + K E D LK +
Sbjct: 81 QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID-LKDLEAQIEAANKARDEVI 139
Query: 952 XXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAG 1011
QA +K D Q+ + + + +K ++ LE EI ++ + ++
Sbjct: 140 KQLRKLQAQMK----DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 195
Query: 1012 LSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFAN 1071
+ + A+ + ++ DEI + S S +EK RL+ IA+L++ + + + ++ +
Sbjct: 196 RARRH--AEQERDELADEITNSAS-GKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 252
Query: 1072 KYK----ALENENSNLSNQCKTLTEEMKNREAQINKLSADLK 1109
+++ ++ N+ L+ + ++ ++ N Q+ + + +LK
Sbjct: 253 RFRKTTLQVDTLNAELAAE-RSAAQKSDNARQQLERQNKELK 293
Score = 62.5 bits (145), Expect = 1e-08
Identities = 92/424 (21%), Positives = 182/424 (42%), Gaps = 37/424 (8%)
Query: 679 KLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLELNEQEATV-----LRRKVEELE 732
+L + A + +E E+ DE E KL LE+N Q L+ + E+ E
Sbjct: 24 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 83
Query: 733 QDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKK 792
+ K L KQV+EL +++ K +R+L S K E +K LE +I+ K
Sbjct: 84 EKKRLLIKQVRELEAELEDERK---------QRALAVASKKKMEIDLKDLEAQIEAANKA 134
Query: 793 LIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQ 852
E + +L A++ Q++ + SR D Q+ + +++L+ + EA +L+ + +
Sbjct: 135 RDEVIKQLRKLQAQMKDYQRELEEARASR--DEIFAQSKESEKKLKSL--EAEILQLQEE 190
Query: 853 SLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQ 912
++ + E ++ +L + S K+ L+ K+ +LE A+I +LE +
Sbjct: 191 LASSERARRHAEQERDELADEITNSASGKSALLDEKR--RLE-------ARIAQLEEELE 241
Query: 913 DEKSEKKV---RFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQ 969
+E+S ++ RF + T + DTL ++ LK+ + +
Sbjct: 242 EEQSNMELLNDRFRKTT-LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELE 300
Query: 970 KSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLE-KEI 1027
+ K + + L K+ QL++ +E E +++ KE+ + + E +
Sbjct: 301 GAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA 360
Query: 1028 DEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNA---KLEGDKDVFANKYKALENENSNLS 1084
D+ + ++ K ++ K +L+ + NA KL+ + D + L E S L
Sbjct: 361 DQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 420
Query: 1085 NQCK 1088
N+ +
Sbjct: 421 NRLR 424
Score = 59.3 bits (137), Expect = 1e-07
Identities = 75/338 (22%), Positives = 142/338 (42%), Gaps = 41/338 (12%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDI------LLRRLANIDTANKYTTGR 315
+ + +K+YQ ++E + D + + + EK+ + L LA+ + A ++
Sbjct: 145 LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQE 204
Query: 316 SSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPST--------EAQTRQI 367
E L ++ + L DEK+ L +I ++E ELE S T Q+
Sbjct: 205 RDE---LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQV 261
Query: 368 EQLRAKLLAAETLCE-------ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSL 420
+ L A+L A + + +L +N+++K +L++L + L
Sbjct: 262 DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL 321
Query: 421 RRELEQTIKNCRVLSFKLKKTERKADQL------EQEKAEHEKKLLEIVGGPDGMQRENR 474
+LEQ K + +++TE+K ++ E+ A+ K+ +E Q + +
Sbjct: 322 EEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM-KQLKRQ 380
Query: 475 IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQED 534
++E E+E R+ +LQREL +A T +N L + V ++ L RGG
Sbjct: 381 LEEAEEEATRANASRRKLQRELDDA----TEANEGLSR-----EVSTLKNRLRRGGPISF 431
Query: 535 PAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
+ Q LE A L + E +T++ + PP
Sbjct: 432 SSSRSGRRQLHLE-GASLELSDDDTESKTSDVNETQPP 468
Score = 57.6 bits (133), Expect = 4e-07
Identities = 73/301 (24%), Positives = 126/301 (41%), Gaps = 28/301 (9%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
V NV E + L+Q+V+ +R + E +E E A D K + + +K
Sbjct: 18 VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ-------ATEDA--KLRLEVNMQAMK 68
Query: 322 LQQKVNELTTHNEDLRDEKKHLTQKIREIESELE-TRPSTEAQTRQIEQLRAKLLAAETL 380
Q + +L T +E ++K+ L +++RE+E+ELE R +++ L E
Sbjct: 69 AQFE-RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ 127
Query: 381 CEELMDENEDMKKELRDLXXXXXXMQDNFREDQA--DEYSSLRRELEQTIKNCRV----L 434
E +++ K+LR L Q E +A DE + +E E+ +K+ L
Sbjct: 128 IEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL 187
Query: 435 SFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQR 494
+L +ER EQE+ E ++ G + E R LE +A +L+
Sbjct: 188 QEELASSERARRHAEQERDELADEITNSASGKSALLDEKR--RLEARIA-------QLEE 238
Query: 495 ELAEANSKFTGSNPSLMKVP-QPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
EL E S N K Q +T+ ++ + D A+ + Q+ E +A L+
Sbjct: 239 ELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNK-ELKAKLQ 297
Query: 554 E 554
E
Sbjct: 298 E 298
Score = 49.6 bits (113), Expect = 1e-04
Identities = 78/341 (22%), Positives = 141/341 (41%), Gaps = 40/341 (11%)
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCE-----RLHAELSLAQKKPKTLIKSRSLDASDQQN 830
E+ + LE +++E+R +L E E + + +L E+++ K + R L D+QN
Sbjct: 26 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF---ERDLQTRDEQN 82
Query: 831 VDLKRQL--QVIEQEASVLRAKTQSL--EADNEKLQTENKKLQLLKNAKSLRSDKALDLN 886
+ KR L QV E EA + + Q A +K++ + K L+ A + D+ +
Sbjct: 83 EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQL 142
Query: 887 TKKTTQLEN---ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
K Q+++ EL+EA A E+ Q ++SEKK++ EA + +
Sbjct: 143 RKLQAQMKDYQRELEEARASRDEI--FAQSKESEKKLKSLEAEILQLQEELASSERARRH 200
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
A+ KS D ++ + RI + + E+LE E M
Sbjct: 201 AEQERDELADEITNSASGKSALLDEKRRLEARIAQ-------------LEEELEEEQSNM 247
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE 1063
++ + KT L+ +D + ++L+ S N Q + K++ AKL+
Sbjct: 248 ELL--------NDRFRKTTLQ--VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 297
Query: 1064 GDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
+ +K+KA + Q + E+ A NKL
Sbjct: 298 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 338
Score = 47.2 bits (107), Expect = 6e-04
Identities = 74/365 (20%), Positives = 145/365 (39%), Gaps = 44/365 (12%)
Query: 1225 ELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKI-TSLESTIAAKDVHIKQLEDAL 1283
E+ ++ +EL+ TE + LE M+ +KA +E + T E K + IKQ+ +
Sbjct: 38 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE 97
Query: 1284 RQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMA 1343
+ +++ A + +M +L + + ++E ++
Sbjct: 98 AELEDERKQRALAVASKKKMEI--------------DLKDLEAQIEAANKARDEVIKQLR 143
Query: 1344 QLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTD---LQSERKKLDRMRIAHDK 1400
+L++ + + S E K K L+ + LQ E +R R H +
Sbjct: 144 KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR-RHAE 202
Query: 1401 DVKNKDAELAT--LKGKLKILEQNSGAGAKRITELKQEYEET-----------------V 1441
+++ A+ T GK +L++ A RI +L++E EE V
Sbjct: 203 QERDELADEITNSASGKSALLDEKRRLEA-RIAQLEEELEEEQSNMELLNDRFRKTTLQV 261
Query: 1442 KKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEI 1501
L LA E++ ++ + LE ++ KA+L + + + L +G++
Sbjct: 262 DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL 321
Query: 1502 KTLQEKLGTESAAWN-----TEKTEMQNSIASLQERLCGGGWEVERARLNARLDQREREL 1556
+ E+ E AA N TEK + + ER ++ + + NAR+ Q +R+L
Sbjct: 322 EEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL 381
Query: 1557 RAAND 1561
A +
Sbjct: 382 EEAEE 386
Score = 38.3 bits (85), Expect = 0.28
Identities = 35/140 (25%), Positives = 60/140 (42%), Gaps = 18/140 (12%)
Query: 1640 MRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSARIHRNSISSTDEEEYRN 1699
M +LK L Q+ + RD + L Q M + + + AR R+ I + +E +
Sbjct: 117 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEK- 175
Query: 1700 KVALLEQQVACLEDELCESRL-----------LASKLNTE------LVSEKSSAEVRLAE 1742
K+ LE ++ L++EL S LA ++ L+ EK E R+A+
Sbjct: 176 KLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQ 235
Query: 1743 MQSRLNEYEEERLLSSGRAR 1762
++ L E + L + R R
Sbjct: 236 LEEELEEEQSNMELLNDRFR 255
>AK125925-1|BAC86346.1| 623|Homo sapiens protein ( Homo sapiens
cDNA FLJ43937 fis, clone TESTI4013924. ).
Length = 623
Score = 64.5 bits (150), Expect = 4e-09
Identities = 145/639 (22%), Positives = 266/639 (41%), Gaps = 67/639 (10%)
Query: 285 KRC-ERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHL 343
KRC ER +KEK+ + + ++ + + L++ ++ E+ H + E+KH
Sbjct: 21 KRCMERKDKEKAHLA----SQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHA 76
Query: 344 TQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXX 403
+I E+ TR + +A T+Q E+ ++L +E L EE ED+K + ++
Sbjct: 77 DLQISEL-----TRHAEDA-TKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWK 130
Query: 404 XMQDNFR---EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAE-HEKKL 459
E Q++ L + Q +K L +L ++ + L +E + K+
Sbjct: 131 LKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRA 190
Query: 460 LEIVGGPDGMQRENRIK----ELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQ 515
L+ ++ IK +LE EV S + RL+ EL + SK S MKV +
Sbjct: 191 LQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL-KKQSKI----QSQMKVEK 245
Query: 516 PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRN--AEEETANCKQVNPPT 573
++ + L + +Q D A+LL ++Q+S++ + +R L N AEEE A K V
Sbjct: 246 AH-LEEEIAELKKSQAQ-DKAKLL-EMQESIKDLSAIRADLANKLAEEERAK-KAV---- 297
Query: 574 FLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFH 633
+ ++D + ET T Q K+ K+ + S L KT E
Sbjct: 298 ---LKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSS--LQSVKTKHEQNIQ 352
Query: 634 FDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE- 692
+ + A N++R A ES L+ K MA R + ++L+ E
Sbjct: 353 ELMKHFKKEKSEAENHIRTLKA------ES--LEEKNMAKIHRGQLEKLKSQCDRLTEEL 404
Query: 693 TANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV 752
T N+N+ K+ + +K LE E+ ++ + +E+ + LK Q+ L ++ S+
Sbjct: 405 TQNENENKKL-KLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 463
Query: 753 TKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEID---EVRKKLIEKERDCERLHAELSL 809
A ++ + +S E++KV D + + L E + + L EL
Sbjct: 464 LGVIGKEIDAACKTFSKDS----VEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKE 519
Query: 810 AQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL-QTENKKL 868
+ + K L L +N + E + S L+ Q +E + L + +K
Sbjct: 520 RENREKNLRHQLMLCRQQLRN--------LTENKESELQCLFQQIERQEQLLDEIHREKR 571
Query: 869 QLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKEL 907
LL+ + R D+ + + LE + AL ++ +
Sbjct: 572 DLLEETQ--RKDEEMGSLQDRVIALETSTQVALDHLESV 608
Score = 60.1 bits (139), Expect = 8e-08
Identities = 91/415 (21%), Positives = 178/415 (42%), Gaps = 38/415 (9%)
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
E+K +E ++E L +VE L ++ E +KQ ++ ++ + + + R+
Sbjct: 19 EVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEI-QNHFDTCEAERKHAD 77
Query: 769 TNSNKL---AEERVKVLEDEIDEVR-----KKLIEKERDCERLHAELSLAQKKPKTLIKS 820
++L AE+ K E + E++ K+ EK R+ +L A+ S+ Q K K
Sbjct: 78 LQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLE 137
Query: 821 RSLDASDQQNVDLK-RQLQVIEQEASV---LRAKTQSLEADNEKLQTENKKLQLLKNAKS 876
R+L+ + +L + Q+++++ + L A Q +E ++L K L +
Sbjct: 138 RALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELH 197
Query: 877 LRSDKALDLNTKKTTQLENELKEALAKIKELEM-ICQDEKSEKKVRFTEA-TKKETDTLK 934
+ +K D+ + + LE E+K +L I LE + + K + +++ +A ++E LK
Sbjct: 198 SKEEKLRDIKSHQA-DLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELK 256
Query: 935 SKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKK--- 991
Q +A L + + +++ K + K +DLT + + +
Sbjct: 257 KSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERA-KKAVLKDLSDLTAQAKSRDEET 315
Query: 992 --MVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQ 1049
++ L+ E +K+ L+ + KTK E+ I E+ K SE N L+
Sbjct: 316 ATIITQLKLERDVHQRELKD--LTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLK 373
Query: 1050 TEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
E + K++ AK+ + L +QC LTEE+ E + KL
Sbjct: 374 AESLEEKNM-AKIH-------------RGQLEKLKSQCDRLTEELTQNENENKKL 414
Score = 52.4 bits (120), Expect = 2e-05
Identities = 96/497 (19%), Positives = 207/497 (41%), Gaps = 30/497 (6%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
K+ + +E + VD L + ++ KEK ++ + A + + + K +
Sbjct: 134 KKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQE 193
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET-LCEELM 385
EL + E LRD K H E+++ L+T E++ ++ ++++++ + L EE+
Sbjct: 194 EELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIA 253
Query: 386 DENEDMKKELRDLXXXXXXMQD--NFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ + ++ L ++D R D A++ + R + +K+ L+ + K +
Sbjct: 254 ELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDE 313
Query: 444 KA----DQLEQEKAEHEKKLLEIVGGPDGM--QRENRIKELEQEVARSTEVALRLQRELA 497
+ QL+ E+ H+++L ++ + + E I+EL + + A R L
Sbjct: 314 ETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTL- 372
Query: 498 EANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQ-EDPAQLLRDLQDSLEREADLREQL 556
+A S N + + Q E +K LT +Q E+ + L+ L+ + + RE+
Sbjct: 373 KAES-LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKH 431
Query: 557 RNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKS 616
+ EEE + + ++ + + C E E++ I K I AA SK+
Sbjct: 432 ISIEEEHLRRME-------EARLQLKDQLLCLETEQESILGVI-GKEIDAACKTFSKDSV 483
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE-DNESLLLQLKKMATKA 675
+ + + H+D P+ + + L+ ++E +N L+ + M +
Sbjct: 484 E----KLKVFSSGPDIHYD-PHRWLAE--SKTKLQWLCEELKERENREKNLRHQLMLCRQ 536
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLEL--NEQEATVLRRKVEELEQ 733
+ R L+ + + + E+ DE + LL E ++E L+ +V LE
Sbjct: 537 QLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALET 596
Query: 734 DKEALKKQVKELTSKIS 750
+ ++ + K+S
Sbjct: 597 STQVALDHLESVPEKLS 613
Score = 41.5 bits (93), Expect = 0.030
Identities = 77/399 (19%), Positives = 158/399 (39%), Gaps = 31/399 (7%)
Query: 1385 QSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETV--- 1441
++ERK D + ++ + +L+ E KR +LK + +E++
Sbjct: 70 EAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQW 129
Query: 1442 ----KKLEHSLALEKAEYEELTGKYE--LLEEEHVVTKARLTVEK-EQAQGELLHVQKEL 1494
KKLE +L + +ELTGK L E++ + T+ +++ E + EL V +
Sbjct: 130 KLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKR 189
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASL--------QERLCGGGWEVERARLN 1546
+ E+ + +EKL + + E++NS+ ++ ++ +VE+A L
Sbjct: 190 ALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLE 249
Query: 1547 ARLDQRERELRAANDRRDVLEHHHD--XXXXXXXXXXXXXXDYERVSK-IQRXXXXXXXX 1603
+ + ++ A D+ +LE + ER K + +
Sbjct: 250 EEIAELKKS--QAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQ 307
Query: 1604 XXXXXXXXXXXIEQSEKAR---KAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDN 1660
I Q + R + E+ D + + ++ L + + E +N
Sbjct: 308 AKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAEN 367
Query: 1661 YKQMLEA---AQKSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCE 1717
+ + L+A +K+MA+I G + + + + N+ L+ + CL+D+L E
Sbjct: 368 HIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQL-E 426
Query: 1718 SRLLASKLNTELVSEKSSAEVRLAEMQSRLNEYEEERLL 1756
R + E + A ++L + Q E E+E +L
Sbjct: 427 EREKHISIEEEHLRRMEEARLQLKD-QLLCLETEQESIL 464
Score = 38.3 bits (85), Expect = 0.28
Identities = 56/289 (19%), Positives = 120/289 (41%), Gaps = 25/289 (8%)
Query: 1228 SEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTT 1287
SE + +A + E + L+ + ++ ++ K LE + + + +L Q
Sbjct: 99 SELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQIL 158
Query: 1288 NDKYDEAT---SPVEMVE-MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMA 1343
+K + T + ++ +E +R ++EL++ + KL ++ + +LE+
Sbjct: 159 KEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVK 218
Query: 1344 QLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVK 1403
+ +LE+ ++ E + EL ++ KL M+ + +K
Sbjct: 219 NSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQ----ESIK 274
Query: 1404 NKDAELATLKGKLKILEQNSGAGAKRITEL----KQEYEET---VKKLEHSLALEKAEYE 1456
+ A A L KL E+ A K +++L K EET + +L+ + + E +
Sbjct: 275 DLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELK 334
Query: 1457 ELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQ 1505
+LT + ++ +H ++ Q + H +KE S A I+TL+
Sbjct: 335 DLTSSLQSVKTKH----------EQNIQELMKHFKKEKSEAENHIRTLK 373
>AF112218-1|AAF17206.1| 742|Homo sapiens unknown protein.
Length = 742
Score = 64.5 bits (150), Expect = 4e-09
Identities = 117/540 (21%), Positives = 230/540 (42%), Gaps = 40/540 (7%)
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAE--HEKKLLEIVGGPDGMQREN--RI 475
LR+ELE+ + +L++ E + +L+QE + + + RE R+
Sbjct: 188 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV 247
Query: 476 KELEQEVARSTEVALRLQ------RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRG 529
+LE EV+R E ++ EL E N + L Q E + L
Sbjct: 248 DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED--QLEGTRARSDKLHE- 304
Query: 530 GSQEDPAQLLRDLQD-SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCD 588
+++ QL L D +ER+ D R+++ EE + + +D+ + +
Sbjct: 305 -LEKENLQLKAKLHDMEMERDMD-RKKIEELMEENMTLEMAQKQS-MDESLHLGWELE-Q 360
Query: 589 IHESETVTNSIQNKMIHAAS--TPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMA 646
I + ++ + Q + H + T S K + S+ KT EE + D + +
Sbjct: 361 ISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 420
Query: 647 ANNLRKTAARVEEDNESLLLQLKKMATKAR--SRKLSPTPPANKLSIETANDNDEKETDE 704
+ ++ E E+ ++Q K+ + S+ L + +IET +N E++
Sbjct: 421 MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI 480
Query: 705 ADPAEMKL---LLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSV--TKTSAGS 759
+ L + L ++ +V+++E++ + L + +KE +SK+S + K
Sbjct: 481 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 540
Query: 760 NTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK 819
+ + +L E + LE E + ++KK+ + CE++ A L Q+ + +
Sbjct: 541 ELEHYKEKGERAEEL-ENELHHLEKENELLQKKITNLKITCEKIEA---LEQENSELERE 596
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL-QLLKNAKSLR 878
+R L + +L QL+ +E+E S L + L + E L+ + K+ QL K L
Sbjct: 597 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 656
Query: 879 SDKALDLNTKKTTQLENELKEALAKIKELEMICQ--DEKSEKKVRFTEATKKETDTLKSK 936
S+K KK +L LK + K + LE+ Q D ++++ + E + K+ L+S+
Sbjct: 657 SEKE---QLKKGLEL---LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 710
Score = 59.3 bits (137), Expect = 1e-07
Identities = 112/595 (18%), Positives = 253/595 (42%), Gaps = 51/595 (8%)
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLD-KQVMTDNIVTCDIHE 591
E L +L D+ + LR++L E+ +CKQ ++ K++ +N+
Sbjct: 169 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENM------- 221
Query: 592 SETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR 651
+ + ++ ++ + +EK+ + +DK E + + + F L+
Sbjct: 222 --NLLSDARSARMYRDELDALREKA----VRVDKLESEVSRYKERLHDIEFYKARVEELK 275
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPAN-----KL-SIETANDNDEKETDEA 705
+ + E L QL+ T+ARS KL N KL +E D D K+ +E
Sbjct: 276 EDNQVLLETKTMLEDQLE--GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL 333
Query: 706 DPAEMKLLLELNE--QEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTA 763
M L + + E+ L ++E++ + E + K L +++ +T +
Sbjct: 334 MEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 393
Query: 764 RRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL 823
+SLT K EE ++ D ++ K+++ E++ +RL ++ + + + + + +SL
Sbjct: 394 NQSLT----KTVEE-LRTTVDSVEGNASKILKMEKENQRLSKKVEILEN--EIVQEKQSL 446
Query: 824 DASDQQNVDLKRQLQVIEQEASVLRAKTQS----LEADNEKLQTENKKLQLLKNAKSLRS 879
+ DL ++ +E+ LR ++ LE +NE L N+ + L+ + +
Sbjct: 447 QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQRSQISA 503
Query: 880 DKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXX 939
+ + K+ L +KE +K+ ++E + + +K++ + + + L+++
Sbjct: 504 EARVKDIEKENKILHESIKETSSKLSKIEF--EKRQIKKELEHYKEKGERAEELENELHH 561
Query: 940 XXXXXXXXXXXXXXXXXXQATLKSL-KDDAQKSFKPRIPKKPTD----LTTKLQ-LKK-- 991
+++L +++++ + R KK D LT +L+ L+K
Sbjct: 562 LEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 621
Query: 992 -MVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQ 1049
+++ E+ +K A + ++ + K LE E ++++ L + F + RL+
Sbjct: 622 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF-KKTERLE 680
Query: 1050 TEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
L N +L+ + K + LE+E +L + +TL + ++ + +L
Sbjct: 681 VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 735
Score = 50.4 bits (115), Expect = 6e-05
Identities = 74/309 (23%), Positives = 141/309 (45%), Gaps = 22/309 (7%)
Query: 265 NVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQ 324
+++ Q+ + L +E L K E + +E S+ R++ ++ N++ S + + Q
Sbjct: 445 SLQNCQNLSKDLMKEKAQLEKTIETL-RENSE---RQIKILEQENEHLNQTVSSLRQRSQ 500
Query: 325 KVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTR-QIEQLRAKLLAAETLCEE 383
E +D+ E K L + I+E S+L + Q + ++E + K AE L E
Sbjct: 501 ISAEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 558
Query: 384 LMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKK 440
L ENE ++K++ +L ++ E + E R+L++T+ + + L+F+L+
Sbjct: 559 LHHLEKENELLQKKITNLKITCEKIEA--LEQENSELERENRKLKKTLDSFKNLTFQLES 616
Query: 441 TERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEAN 500
E++ QL++E E + + + M + +LE + S + L+ EL +A+
Sbjct: 617 LEKENSQLDEENLELRRNVESLKCASMKMAQ----LQLENKELESEKEQLKKGLELLKAS 672
Query: 501 SKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAE 560
K T L Q ++ R T S + QL +LQD LE E + +N E
Sbjct: 673 FKKT---ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD-LEMENQTLQ--KNLE 726
Query: 561 EETANCKQV 569
E + K++
Sbjct: 727 ELKISSKRL 735
Score = 47.2 bits (107), Expect = 6e-04
Identities = 112/544 (20%), Positives = 220/544 (40%), Gaps = 59/544 (10%)
Query: 277 KQEVDILRKRCERVEKEKSDI--LLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNE 334
+ E+D LR++ RV+K +S++ RL +I+ + R E+ + Q + E T E
Sbjct: 234 RDELDALREKAVRVDKLESEVSRYKERLHDIE----FYKARVEELKEDNQVLLETKTMLE 289
Query: 335 DLRDEKKHLTQKIREIESE-LETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKK 393
D + + + K+ E+E E L+ + + + R K+ EELM+EN M
Sbjct: 290 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI-------EELMEEN--MTL 340
Query: 394 ELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKA 453
E+ + + +Q S L ++++ + V T + +LE E
Sbjct: 341 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH-EVNEL----TSSRLLKLEMENQ 395
Query: 454 EHEKKLLEIVGGPDGMQ-RENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMK 512
K + E+ D ++ ++I ++E+E R ++ L+ E+ + +L K
Sbjct: 396 SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ-NLSK 454
Query: 513 VPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPP 572
E ++ ++ T + E ++L + L + LR + +A +
Sbjct: 455 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTV---SSLRQRSQISAEARV---- 507
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
K + +N + +HES T+S +K I KE E +
Sbjct: 508 ----KDIEKENKI---LHESIKETSSKLSK-IEFEKRQIKKELEHYKEKGERAEELENEL 559
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIE 692
H L + NL+ T ++E L+ + + +RKL T + K ++
Sbjct: 560 H-HLEKENELLQKKITNLKITCEKIE------ALEQENSELERENRKLKKTLDSFK-NLT 611
Query: 693 TANDNDEKETDEADPAEMKL-----LLELNEQEATVLRRKVEELEQDKEALKKQVKELTS 747
++ EKE + D ++L L+ + L+ + +ELE +KE LKK ++ L +
Sbjct: 612 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 671
Query: 748 KISSVTKTSAG------SNTTARRSLTTNSNKL--AEERVKVLEDEIDEVRKKLIEKERD 799
+ N +++L ++ K+ E ++ LE E ++K L E +
Sbjct: 672 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 731
Query: 800 CERL 803
+RL
Sbjct: 732 SKRL 735
Score = 42.3 bits (95), Expect = 0.017
Identities = 42/171 (24%), Positives = 84/171 (49%), Gaps = 17/171 (9%)
Query: 1374 ENKAKELDTDLQSERKKLDR-MRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITE 1432
EN +++ L+ E + L++ + + + +A + ++ + KIL ++ + ++++
Sbjct: 472 ENSERQIKI-LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 530
Query: 1433 LKQEYEETVKKLEHSLALEKAE-YEELTGKYELLEEEH-----VVTKARLTVEK----EQ 1482
++ E + K+LEH EK E EEL + LE+E+ +T ++T EK EQ
Sbjct: 531 IEFEKRQIKKELEH--YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 588
Query: 1483 AQGELLHVQKELSTALGEIKTLQ---EKLGTESAAWNTEKTEMQNSIASLQ 1530
EL ++L L K L E L E++ + E E++ ++ SL+
Sbjct: 589 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK 639
>AY282407-1|AAP40331.1| 1116|Homo sapiens M-phase phosphoprotein 1
protein.
Length = 1116
Score = 64.1 bits (149), Expect = 5e-09
Identities = 138/730 (18%), Positives = 288/730 (39%), Gaps = 53/730 (7%)
Query: 416 EYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLL-------EIVGGPDG 468
+++ ++ EL +T +LKK E ++D L QE KK++ E++ D
Sbjct: 12 KFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSIKKIITQNQRIKELINIID- 70
Query: 469 MQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTR 528
Q+E+ I E Q + E + + A+ +S N L+ E K S+S +
Sbjct: 71 -QKEDTINEF-QNLKSLMENTFKCN-DKADTSSLII--NNKLICNETVEVPKDSKSKICS 125
Query: 529 GGSQEDPAQLLRD----LQDSLEREADLREQLRNAEEETANCKQVNPPTFLDK--QVMTD 582
+ + +L +D + S+ + + E + +EE N ++ L + + +
Sbjct: 126 ERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRA 185
Query: 583 NIVTCD--IHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLS 640
++T + + + + +++H S EK + L++ K ++ Q ++D+
Sbjct: 186 FLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKN---LTLSKEVQQIQSNYDIAIAE 242
Query: 641 IFNHMAANN-----LRKTAARVEEDNESL---LLQLKKMATKARS-RKLSPTPPANKLSI 691
+ + N + K + +E S+ + Q+K M TK R L + + +
Sbjct: 243 LHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDL 302
Query: 692 ETAND-NDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKIS 750
D ++ E D ++ LL V +++E ++ + ++ + +
Sbjct: 303 LNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNREN-SFHSSIEAIWEECK 361
Query: 751 SVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLA 810
+ K S+ + L KL E VK +DE + +++K + + D + E +
Sbjct: 362 EIVKASSKKSHQIEE-LEQQIEKLQAE-VKGYKDENNRLKEKEHKNQDDLLK-EKETLIQ 418
Query: 811 QKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL 870
Q K + K+ +LD Q V+ KR L + Q + +AK + LE E + E
Sbjct: 419 QLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVERSHSAK 478
Query: 871 LKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKET 930
L+ + L L + + + L++++ K+L + + + E+ + T +
Sbjct: 479 LEQDILEKESIILKLE-RNLKEFQEHLQDSVKNTKDLN-VKELKLKEEITQLTNNLQDMK 536
Query: 931 DTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKL-QL 989
L+ K+ A ++LK D Q R + DL KL
Sbjct: 537 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQ-----RKEEDYADLKEKLTDA 591
Query: 990 KKMVEDLECEIGEMYVVMKNAGLSGKEM-TAKTKLEKEIDEIRSKLSKNDSEFTNEK--N 1046
KK ++ ++ E+ M K + E+ K + +E+D + + + + N+K
Sbjct: 592 KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE 651
Query: 1047 RLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSA 1106
+Q KD+N K + + + LE + Q + L +++ E +L
Sbjct: 652 AIQQYERACKDLNVK----EKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEK 707
Query: 1107 DLKNATSLQT 1116
+ L+T
Sbjct: 708 WKEKCNDLET 717
Score = 55.6 bits (128), Expect = 2e-06
Identities = 148/804 (18%), Positives = 320/804 (39%), Gaps = 89/804 (11%)
Query: 317 SEVLKLQQKVNELTTHNEDLRDEKKHLTQK---IREIESELETRPSTEAQTRQIEQLRAK 373
S + +L+ + ++ T N+ +++ + QK I E ++ L++ + +
Sbjct: 43 SLIQELETSIKKIITQNQRIKELINIIDQKEDTINEFQN-LKSLMENTFKCNDKADTSSL 101
Query: 374 LLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRV 433
++ + +C E ++ +D K ++ + N E Q DE + + +
Sbjct: 102 IINNKLICNETVEVPKDSKSKI-----CSERKRVNENELQQDEPPAKKGSIH-------- 148
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQR-----ENRIKELEQEVARSTEV 488
+S + + ++K++++ AE E + + +G++ EN +K ++E A +
Sbjct: 149 VSSAITEDQKKSEEVRPNIAEIED-IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQ 207
Query: 489 ALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLER 548
+ Q+EL+ + K + + ++ + ++ + + +QE ++++ S E
Sbjct: 208 IVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKL---SNEI 264
Query: 549 EADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHE--SETVTNSIQNKMIHA 606
E R N + +++ LD NI ++ + + + +++ N +
Sbjct: 265 ETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDL 324
Query: 607 ASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLL 666
K I + E FH + +I+ + K +++ E L
Sbjct: 325 LGNDYLVSKQVKE-YRIQEPNRENSFHSSIE--AIWEE--CKEIVKASSKKSHQIEELEQ 379
Query: 667 QLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRR 726
Q++K+ + + K N+L E + N + E + +L EL E+ T L
Sbjct: 380 QIEKLQAEVKGYK----DENNRLK-EKEHKNQDDLLKEKETLIQQLKEELQEKNVT-LDV 433
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
+++ + + K AL + + +T + + + T K+ LE +I
Sbjct: 434 QIQHVVEGKRALSELTQGVTCYKAKIKELETILET----------QKVERSHSAKLEQDI 483
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTL-IKSRSLDASDQQ---NV-DLKRQLQVIE 841
E +++ ER+ + L + K K L +K L Q N+ D+K LQ+ E
Sbjct: 484 LEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKE 543
Query: 842 QEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEAL 901
+E R +T+ L+ E+L + + Q LK + + DL K T + K+ +
Sbjct: 544 EEEETNRQETEKLK---EELSASSARTQNLKADLQRKEEDYADLKEKLT-----DAKKQI 595
Query: 902 AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATL 961
++++ + +DE +++ E KK+ + Q T+
Sbjct: 596 KQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMK------------------QRTI 637
Query: 962 KSLKDDAQKSFKPRIPKKPTDLTTKLQLK-KMVEDLEC--EIGEMYVVMKNAGLSGKEMT 1018
+ LK+ ++ L +K K++ED+ E E V ++ L K
Sbjct: 638 QQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEE 697
Query: 1019 AK---TKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKL-EGDKDVFANKYK 1074
+ T+LEK ++ +KN+ E + KL ++ +L E ++ A++ K
Sbjct: 698 VERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKK 757
Query: 1075 ALENENSNLSNQCKTLTEEMKNRE 1098
LE E L Q K E ++N+E
Sbjct: 758 WLE-EKMMLITQAKE-AENIRNKE 779
Score = 54.0 bits (124), Expect = 5e-06
Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 23/302 (7%)
Query: 1384 LQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILE-QNSGAGAKRITELKQEYEET-- 1440
L+ ER + D KD + LK K +I + N+ K + +LK+E EET
Sbjct: 491 LKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNR 550
Query: 1441 --VKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTAL 1498
+KL+ L+ A + L + EE++ K +LT K+Q + VQKE+S
Sbjct: 551 QETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQ----IKQVQKEVSVMR 606
Query: 1499 GEIKTLQEKLGTESAAWNTEKTEM---QNSIASLQERLCGGGWEVERARLNARLDQRERE 1555
E K L+ K+ N E+ Q +I L+E+L +VE A + Q ER
Sbjct: 607 DEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL--NNQKVEEA-----IQQYERA 659
Query: 1556 LRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXI 1615
+ N + ++E + ++V + + +
Sbjct: 660 CKDLNVKEKIIE----DMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL 715
Query: 1616 EQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI 1675
E R + + T G++ ++DEL+ + + R++ K ML K I
Sbjct: 716 ETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENI 775
Query: 1676 KN 1677
+N
Sbjct: 776 RN 777
Score = 48.8 bits (111), Expect = 2e-04
Identities = 119/571 (20%), Positives = 235/571 (41%), Gaps = 72/571 (12%)
Query: 310 KYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ 369
K ++ +S ++ +L+Q++ +L + +DE L +K + + +L
Sbjct: 365 KASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDL--------------- 409
Query: 370 LRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIK 429
L+ K + L EEL ++N + +++ + + + Y + +ELE ++
Sbjct: 410 LKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSE--LTQGVTCYKAKIKELETILE 467
Query: 430 NCRVLSFKLKKTERK-ADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEV 488
+K ER + +LEQ+ E E +L++ Q +++ +
Sbjct: 468 T--------QKVERSHSAKLEQDILEKESIILKLERNLKEFQ--EHLQDSVKNTKDLNVK 517
Query: 489 ALRLQRELAEANSKFTGSNPSL-MKVPQPETVKVSRSSLTR--GGSQEDPAQLLRDLQDS 545
L+L+ E+ + + L +K + ET + L S L DLQ
Sbjct: 518 ELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRK 577
Query: 546 LEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKM-I 604
E ADL+E+L +A+++ KQV + + D ++ I+E E N ++ +
Sbjct: 578 EEDYADLKEKLTDAKKQ---IKQVQKEVSVMRD--EDKLLRIKINELEKKKNQCSQELDM 632
Query: 605 HAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYL-SIFNHMAANNLRKTAARVEEDN-- 661
+ KE+ ++ + + + + DL I M + +VE+D
Sbjct: 633 KQRTIQQLKEQLNNQKVE-EAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVL 691
Query: 662 ESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEA 721
E+ L +++++AT+ K N L + N KE + KL
Sbjct: 692 EAKLEEVERLATELEKWK----EKCNDLETKN-NQRSNKEHENNTDVLGKL--------- 737
Query: 722 TVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV 781
T L+ +++E EQ A +K K L K+ +T+ N + K AE+R +
Sbjct: 738 TNLQDELQESEQKYNADRK--KWLEEKMMLITQAKEAENIRNK-----EMKKYAEDRERF 790
Query: 782 L--EDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQV 839
++E++ + +L EK+ D ++ E Q I+ ++L +S+ Q + QL+
Sbjct: 791 FKQQNEMEILTAQLTEKDSDLQKWREERD--QLVAALEIQLKALISSNVQKDNEIEQLKR 848
Query: 840 IEQEASVLRAKTQSLE------ADNEKLQTE 864
I E S + + ++ AD +KLQTE
Sbjct: 849 IISETSKIETQIMDIKPKRISSADPDKLQTE 879
Score = 40.3 bits (90), Expect = 0.069
Identities = 45/224 (20%), Positives = 96/224 (42%), Gaps = 11/224 (4%)
Query: 270 QDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNEL 329
+ + E LK+E+ R + + K+D+ + D K T + ++ ++Q++V+ +
Sbjct: 550 RQETEKLKEELSASSARTQNL---KADLQRKEEDYADLKEKLTDAKK-QIKQVQKEVSVM 605
Query: 330 TTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQI---EQLRAKLLAAETLCEELMD 386
++ LR + L +K + EL+ + T Q ++ +++ + E C++L
Sbjct: 606 RDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNV 665
Query: 387 EN---EDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTER 443
+ EDM+ L + QD E + +E L ELE+ + C L K +
Sbjct: 666 KEKIIEDMRMTLEEQEQTQVE-QDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN 724
Query: 444 KADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTE 487
K + + L + + + +R K LE+++ T+
Sbjct: 725 KEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQ 768
Score = 35.1 bits (77), Expect = 2.6
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 15/165 (9%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
+K+ Q ++ ++ E +LR + +EK+K+ +D + T + E L QK
Sbjct: 595 IKQVQKEVSVMRDEDKLLRIKINELEKKKNQC----SQELDMKQR-TIQQLKEQLN-NQK 648
Query: 326 VNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
V E E + + I ++ LE + T+ + Q+ L AKL E L EL
Sbjct: 649 VEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQV--LEAKLEEVERLATEL- 705
Query: 386 DENEDMKKELRDLXXXXXXMQDNFREDQAD---EYSSLRRELEQT 427
E K++ DL + E+ D + ++L+ EL+++
Sbjct: 706 ---EKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQES 747
>AL590431-12|CAH71270.1| 242|Homo sapiens tropomyosin 3 protein.
Length = 242
Score = 64.1 bits (149), Expect = 5e-09
Identities = 57/184 (30%), Positives = 92/184 (50%), Gaps = 12/184 (6%)
Query: 760 NTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK 819
N R K AEER K LEDE+ ++KKL E + +R L+ A +K +
Sbjct: 17 NALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDRAQERLATALQKLEE--A 74
Query: 820 SRSLDASDQ-----QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA 874
++ D S++ +N LK + ++ QE + AK + EAD K + +KL +++
Sbjct: 75 EKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD-RKYEEVARKLVIIEGD 133
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEK-SEKKVRFTEATKKETDTL 933
R+++ +L K ++LE ELK +K LE Q EK S+K+ ++ E K TD L
Sbjct: 134 LE-RTEERAELAESKCSELEEELKNVTNNLKSLE--AQAEKYSQKEDKYEEEIKILTDKL 190
Query: 934 KSKQ 937
K +
Sbjct: 191 KEAE 194
Score = 40.3 bits (90), Expect = 0.069
Identities = 44/227 (19%), Positives = 92/227 (40%), Gaps = 20/227 (8%)
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA--RLNARLDQRERELRAANDRR 1563
E+ E ++++ +A++Q++L G E++RA RL L + E +AA++
Sbjct: 23 EQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDRAQERLATALQKLEEAEKAADESE 82
Query: 1564 DVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
++ + + I +E++E+ +
Sbjct: 83 RGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEE--R 140
Query: 1624 AEITDTK-TRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSA 1682
AE+ ++K + E ++ + + LKSL Q ++ ++ D Y++ ++ + E
Sbjct: 141 AELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKE-------- 192
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
+ T E VA LE+ + LEDEL +L ++ EL
Sbjct: 193 -------AETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEEL 232
Score = 36.3 bits (80), Expect = 1.1
Identities = 35/136 (25%), Positives = 62/136 (45%), Gaps = 13/136 (9%)
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
K + + + L T LQ + E E V++N L +E + E+ E
Sbjct: 51 KGTEDELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEE-------KMELQE 103
Query: 1030 IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKT 1089
I+ K +K+ +E E +R E+A+ + +EGD + + + E++ S L + K
Sbjct: 104 IQLKEAKHIAE---EADRKYEEVARKLVI---IEGDLERTEERAELAESKCSELEEELKN 157
Query: 1090 LTEEMKNREAQINKLS 1105
+T +K+ EAQ K S
Sbjct: 158 VTNNLKSLEAQAEKYS 173
Score = 34.3 bits (75), Expect = 4.5
Identities = 43/238 (18%), Positives = 105/238 (44%), Gaps = 13/238 (5%)
Query: 280 VDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL-KLQQKVNELTTHNEDLRD 338
++ ++K+ + ++ +K + L R + K RS ++ +L +L ++L
Sbjct: 1 MEAIKKKMQMLKLDKENAL-DRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDR 59
Query: 339 EKKHLTQKIREIESELETRPSTEAQTRQIEQL----RAKLLAAETLCEELMDENEDMKKE 394
++ L ++++E + +E + IE K+ E +E E+ ++
Sbjct: 60 AQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 119
Query: 395 LRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEK 452
++ ++ + E++A+ S ELE+ +KN ++ LK E +A++ Q++
Sbjct: 120 YEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQAEKYSQKE 176
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
++E+++ + + E R + E+ VA+ + L+ EL K+ + L
Sbjct: 177 DKYEEEIKILT--DKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEEL 232
Score = 33.5 bits (73), Expect = 7.9
Identities = 32/160 (20%), Positives = 67/160 (41%), Gaps = 7/160 (4%)
Query: 1403 KNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKY 1462
K + ELA ++ KLK E +R+ Q+ EE K + S K
Sbjct: 37 KQLEDELAAMQKKLKGTEDELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDE 96
Query: 1463 ELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEM 1522
E +E + + K + E+A + V ++L G+++ +E+ + + + E+
Sbjct: 97 EKMELQEIQLKEAKHI-AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL 155
Query: 1523 QNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
+N +L+ E + + + + D+ E E++ D+
Sbjct: 156 KNVTNNLK------SLEAQAEKYSQKEDKYEEEIKILTDK 189
>AL589986-1|CAH70024.1| 1943|Homo sapiens trichohyalin protein.
Length = 1943
Score = 64.1 bits (149), Expect = 5e-09
Identities = 150/788 (19%), Positives = 303/788 (38%), Gaps = 73/788 (9%)
Query: 173 QLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNST 232
QL K Q ++E E+E +R K + E+ +Y++E +++ L + + R
Sbjct: 898 QLRKEQQLLQEE---EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 233 NLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCERVEK 292
+ R + K+Y+++ E ++E +LR+ E+ +
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE-KKYREEEELQQEEEQLLREEREKRRR 1013
Query: 293 EKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREI-- 350
++ + R+ + + E +LQ++ + E+L+ E++ L + RE
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY-REEEELQQEEEQLLGEERETRR 1072
Query: 351 --ESELETRPSTEAQTRQIEQLR-----AKLLAAETLC---EELMDENEDMKKELRDLXX 400
E E + R E Q + + LR + E C EEL E E + +E R+
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE-KR 1131
Query: 401 XXXXMQDNFRED---QADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEK 457
++ +RE+ Q +E LR E E+ + +L++ R+ ++L+QE E+
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQ------ELERQYREEEELQQE----EE 1181
Query: 458 KLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPE 517
+LL ++E R +E E++ E L+ Q+ + S+ P+ E
Sbjct: 1182 QLLR-------EEQEKRRQERERQYREEEE--LQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232
Query: 518 TVKVSRSSLTRGGSQEDPAQL----LRDLQDSLEREADLREQL-RNAEEETANCKQVNPP 572
+G E QL LRD Q + + L EQ R+ E+E +Q +
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 573 TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQF 632
++Q+ + + + S + K + + + ++ K EE Q
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRK----SQEEKQLLREEREEKRRRQETD----RKFREEEQL 1344
Query: 633 HFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPP---ANKL 689
+ + R+ R +E L + +++ + R RK +
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404
Query: 690 SIETANDNDEK-ETDEADPAEMKLLLELNEQEATVLRRK-----VEELEQDKEALKKQVK 743
+ D D K +E + + + E+E V R++ +EE +Q ++ ++ +
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464
Query: 744 ELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEER-VKVLEDEI--DEVRKKLIEKERDC 800
E + + R+ L +ER K E E+ E +K +E+E+
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 801 ERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK 860
R + Q++ + R + Q+ D R+ + EQ + S + + K
Sbjct: 1525 HRQQRQRKFLQEEQQL----RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Query: 861 LQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKV 920
+ E +K++ + + D+ + QL E K +E E + Q E+ E+++
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR---KFREDEQLLQ-EREEQQL 1636
Query: 921 RFTEATKK 928
E +K
Sbjct: 1637 HRQERDRK 1644
Score = 55.6 bits (128), Expect = 2e-06
Identities = 137/677 (20%), Positives = 265/677 (39%), Gaps = 55/677 (8%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
+E ++Q E +Q+ + ++ R ++E+ + LRR + + E + QQ
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 327 NELTTHNED-LRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELM 385
E E LR E+ Q RE + E + E Q R+ +QLR + EE
Sbjct: 379 REQQLRREQQLRREQ----QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 386 DENEDMKKELRDLXXXXXXMQDNF-REDQADEYSSLRRELEQTIKNCRVLSFKLKKTERK 444
++ + ++ + L +D RE++ + + RR+ Q +K + + ++ ER
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRK--QQLKRDQ----EEERRERW 488
Query: 445 ADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFT 504
E+E+ E +++ + + +RE R+K E+E + LR +++L +
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEE--ERLQQRLRSEQQLRREQEE-- 544
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPA-QLLRD----LQDSLEREADLREQLRNA 559
L+K + + ++ R QE+ QLL+ Q L+RE + R + R
Sbjct: 545 -RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Query: 560 EEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSP 619
EE +Q K+ + + +SE Q ++ +E+ +
Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL--------RREQQERR 655
Query: 620 PLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRK 679
+ + EE + L H R+ EE+ E ++K K + +
Sbjct: 656 EQRLKREEEEERLEQRLKR----EH---EEERREQELAEEEQEQARERIKSRIPKWQWQL 708
Query: 680 LSPTPPA-NKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE-A 737
S +K+ ++ E + + EL QE R+ +E EQ ++
Sbjct: 709 ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768
Query: 738 LKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKE 797
+ Q +E + + R L + E+R E+E ++ R++ E+E
Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 798 RDCERLHAELSL--------AQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQ---EASV 846
++ + L E L Q++ L + + S +Q D K + Q+ E+
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 847 LRAK---TQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENE--LKEAL 901
L AK + L + + LQ E ++LQ + K R ++ ++ Q E E L+E
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Query: 902 AKIKELEMICQDEKSEK 918
K + E Q K +K
Sbjct: 949 EKRRRQERERQYRKDKK 965
Score = 50.0 bits (114), Expect = 8e-05
Identities = 150/770 (19%), Positives = 300/770 (38%), Gaps = 51/770 (6%)
Query: 182 EKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSRNSTNLKPPVRGG 241
EKE + RER + E+E+ + ++ +++ + L + + R S + +
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 242 PXXXXXXXXXXXXXXXXXXLVDSNVKE---YQDQIEGLKQEVDILRKRCERVEKEKSDIL 298
L + KE Q++ E L++E R+R E+ + + +
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ 935
Query: 299 LR----RLANIDTANKYTTGRSSEV---LKLQQKVNELTTHNEDLRDEKKHLTQKIREIE 351
L+ +L + + R + KLQQK +L + R ++ +K RE E
Sbjct: 936 LQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR-RRQEREKKYRE-E 993
Query: 352 SELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFRE 411
EL+ + + ++ R + +EL E E + +E R+ +Q+ RE
Sbjct: 994 EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE----KRRLQE--RE 1047
Query: 412 DQADEYSSLRRELEQTIKNCRVLSFK--LKKTERKADQLEQEKAEHEKKLLEIVGGPDGM 469
Q E L++E EQ + R + L++ RK ++L+QE+ E+ L E
Sbjct: 1048 RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE---EQLLREEPEKRRRQ 1104
Query: 470 QRENRIKELEQEVARSTEVALRLQRE---LAEANSKFTGSNPSLMKVPQ---PETVKVSR 523
+RE + +E E+E+ + E LR +RE E ++ + Q E K R
Sbjct: 1105 ERERQCRE-EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
L R +E+ Q + E+E +E+ R EE +Q + D+ +D
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
+ E E N++++ ++ +E L D + Q DL +L
Sbjct: 1224 KWQWE-PEKE---NAVRDNKVYC----KGRENEQFRQLE-DSQLRDRQSQQDLQHLLGEQ 1274
Query: 644 HMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEK-ET 702
+ + + + QL++ K R+ + +L E + + ET
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 703 DEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTT 762
D E +LL E EQ LRR+ + + +E L+ Q E K +
Sbjct: 1335 DRKFREEEQLLQEREEQP---LRRQERDRKFREEELRHQ--EQGRKFLE-EEQRLRRQER 1388
Query: 763 ARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
R+ L +ER + L + D +K E+E+ R + +++ + + R
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRD---RKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 823 LD-ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDK 881
++Q + +R + E+E + + Q L + ++ QL + + R +
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD-RKFR 1504
Query: 882 ALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD 931
+L +++ + E ++ L + + Q+E+ ++ + +++ D
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Score = 48.0 bits (109), Expect = 3e-04
Identities = 136/782 (17%), Positives = 301/782 (38%), Gaps = 59/782 (7%)
Query: 170 RKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVKNSR 229
R+ Q L+ Q E+E E+E+ R + + E+ +Y++E + + ++ R
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 230 NSTNLK-PPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKRCE 288
+ + P + L DS +++ Q Q + L+ + ++R
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ-QDLQHLLGEQQERDR 1279
Query: 289 RVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIR 348
E+ + R + + + + Q+ +L + + ++ +K R
Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR 1339
Query: 349 EIESELETRPSTEAQTRQIE-QLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQD 407
E E L+ R + ++ + + R + L + + ++E + ++++ R+ Q
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Query: 408 NFREDQ----ADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
+E + D R E +Q + R F+ ++ + + + E++ E E++L +
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ-- 1457
Query: 464 GGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSR 523
+R + +E EQ + E L Q E + KF L + Q K
Sbjct: 1458 ------ERHRKFREEEQLLQEREEQQLHRQ----ERDRKFLEEEQQLRR--QERDRKFRE 1505
Query: 524 SSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDN 583
L SQE + L + + L R+ R+ L+ EE+ ++ D+
Sbjct: 1506 QELR---SQEPERKFLEE-EQQLHRQQRQRKFLQ--EEQQLRRQERGQQRRQDRD----- 1554
Query: 584 IVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFN 643
E E + + + + S K + + +E +F D L
Sbjct: 1555 ---RKFREEEQLRQEREEQQL---SRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR--R 1606
Query: 644 HMAANNLRKTAARVEEDNESLLLQL--KKMATKARSRK-LSPTPPANKLSIE--TANDND 698
LR+ R ++E LL + +++ + R RK L P + E +D D
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD 1666
Query: 699 EKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAG 758
K +E + +L QE R+ E+ + +E +K ++E +
Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFR 1726
Query: 759 SNTTARRSLTTNSNKLAEERVKVLEDE---IDEVRKKLIEKERDCERLHAELSLAQKKPK 815
R+ + E K+LE+E + ++L +ERD + E L Q++ +
Sbjct: 1727 EEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD-RKFREEEQLRQEREE 1785
Query: 816 TLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAK 875
++S+ D ++ L++ E+E LR + + + K + E ++LQL + +
Sbjct: 1786 QQLRSQESDRKFREEEQLRQ-----EREEQQLRPQQR-----DGKYRWEEEQLQLEEQEQ 1835
Query: 876 SLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKS 935
LR ++ ++ + + + ++ + E + ++ E+K+R +++ + +
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH 1895
Query: 936 KQ 937
+Q
Sbjct: 1896 RQ 1897
Score = 47.6 bits (108), Expect = 5e-04
Identities = 87/404 (21%), Positives = 159/404 (39%), Gaps = 29/404 (7%)
Query: 167 ERVRKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTKDDVNFLMQVK 226
ER K + +T F +E + +ERE + L + + D K ++E + FL + +
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR--EEELRHQEQGRKFLEEEQ 1381
Query: 227 NSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRKR 286
R + ++ D +E + Q+ +QE D RK
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDR-----DRKFREEEQQLS--RQERD--RKF 1432
Query: 287 CERVEKEKSDILLRRLANIDTANKYTTGRS-SEVLKLQQKVNELTTHNEDLRDEKKHLTQ 345
E ++ + R+ + + R E +L Q+ E H ++ RD K +
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE-RDRK--FLE 1489
Query: 346 KIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKE--LRDLXXXXX 403
+ +++ + R E + R E R K L E + + +++E LR
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPER-KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548
Query: 404 XMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIV 463
QD R+ + +E RE +Q + R F+L++ + + + E++ E E++L
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 464 GGPD-GMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVS 522
G +R+ + +E EQ + E L Q E + KF P L + + + ++
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQQLHRQ----ERDRKFLEEEPQLRRQEREQQLRHD 1664
Query: 523 RSSLTRGGSQ----EDPAQLLRDLQDSLEREADLREQLRNAEEE 562
R R Q + QL R +D RE + +QLR E E
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEE--QQLRRQERE 1706
Score = 46.8 bits (106), Expect = 8e-04
Identities = 59/292 (20%), Positives = 131/292 (44%), Gaps = 18/292 (6%)
Query: 651 RKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEM 710
R+ R E++ E QL++ R ++L + +E ++
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTN 770
+ +L ++ + E E+ ++ LK++ +E + +T ++ L +
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 771 SNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQN 830
+ ER LE+E E R+ ++ER ++L E +++ + +K + + QQ
Sbjct: 480 QEEERRERWLKLEEE--ERRE---QQERREQQLRRE---QEERREQRLKRQEEEERLQQR 531
Query: 831 VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKT 890
+ ++QL+ ++E + Q L+ + EK + ++ Q LK + R D+ L ++
Sbjct: 532 LRSEQQLRREQEER-----REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR 586
Query: 891 TQ-LENELKEALA---KIKELEMICQDEKSEKKVRFTE-ATKKETDTLKSKQ 937
Q L+ E +E L K +E+E + Q+E+ E++++ E ++ LKS++
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEE 638
Score = 46.0 bits (104), Expect = 0.001
Identities = 131/730 (17%), Positives = 276/730 (37%), Gaps = 49/730 (6%)
Query: 170 RKMQLLKTQNSFEKEPSIEKERERRSLSKSKEDEKTARYKDERSSTK----DDVNFLMQV 225
RK QL + Q +E ++ E E R + + +++ R ++ER + ++ L Q
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 226 KNSRNSTNLKPPVRGGPXXXXXXXXXXXXXXXXXXLVDSNVKEYQDQIEGLKQEVDILRK 285
S + R L +E +DQ+ LK+E + +
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ-EERRDQL--LKREEE---R 585
Query: 286 RCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQ 345
R +R+++E+ + L +RL + R + LK ++ E ++++ Q
Sbjct: 586 RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ 645
Query: 346 KIREIESEL-ETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXX 404
++R + E E R E + ++EQ + E +EL +E ++ +E
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQ 705
Query: 405 MQDNFRED--QADEYS------SLRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHE 456
Q D Q+ YS RR EQ K R S + E +A + +QE+ +
Sbjct: 706 WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765
Query: 457 KKLLEIVG---GPDGMQRENR---IKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
+ G QR + ++E + R+ E R QR L E K
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR 825
Query: 511 MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVN 570
+ + + ++ L R + AQ L++ +D L+ + + R ++ +
Sbjct: 826 EREKELQFLE-EEEQLQR----RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE 880
Query: 571 PPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEET 630
+ + + + + + + ++ +++ + ++ +E
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE 940
Query: 631 QFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLS 690
+ RK +++ + L + +K + R +K +
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000
Query: 691 IETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELE-QDKEALKKQVKELTSKI 749
+ + EK + + + EL ++E +LR + E+ Q++E ++ +EL +
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 750 SSVTKTSAGSNTTARRSLTTNSNK---LAEERVKVLEDEIDEVRKKLIEKERDCERLHAE 806
+ T R+ L K L +E ++L +E ++ R++ E+ER C E
Sbjct: 1061 EQL--LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ--ERERQCRE---E 1113
Query: 807 LSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLR-----AKTQSLE---ADN 858
L Q++ + L + R + + + +V ++E +LR + Q LE +
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 859 EKLQTENKKL 868
E+LQ E ++L
Sbjct: 1174 EELQQEEEQL 1183
Score = 45.6 bits (103), Expect = 0.002
Identities = 57/275 (20%), Positives = 119/275 (43%), Gaps = 18/275 (6%)
Query: 676 RSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDK 735
R R+L P + + + E +E + +L ++ L R+ +E Q++
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEW-QER 183
Query: 736 EALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIE 795
E + + ++L S T+ RR L K EE+ + + D V ++ E
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 796 KE---RDCERLHAELSLAQKKPKTLIKSRSLDASDQQ-----NVDLKRQLQVIEQEASVL 847
KE R+ E L +++P+ + R L ++Q +L+R+ Q EQ+ L
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQ---RQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 848 RAKTQ---SLEADNEKLQTENKKLQLLKNAKSLRSDKAL--DLNTKKTTQLENELKEALA 902
R + Q E + + Q E ++ Q + + R ++ L + ++ QL E +E
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE-R 359
Query: 903 KIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ ++L ++E+ E+++R + ++E + +Q
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Score = 44.8 bits (101), Expect = 0.003
Identities = 126/691 (18%), Positives = 267/691 (38%), Gaps = 39/691 (5%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
+E Q++ E L++ ++ R ER E+E+ LRR + + E + QQ+
Sbjct: 269 RELQEEEEQLRK-LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
E E+ R+++ Q+ R E +L E + +Q+ + + + + L E
Sbjct: 328 RE---QQEERREQQLRREQEERR-EQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
E + + L Q RE Q LRRE Q ++ + L + ++ ER
Sbjct: 384 RREQQLRREQQLRRE----QQLRREQQLRREQQLRRE--QQLRREQQLR-REQEEERHEQ 436
Query: 447 QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGS 506
+ EQE+ E K E D ++RE + EQE R ++ + E E K
Sbjct: 437 KHEQERREQRLKR-EQEERRDWLKREEETERHEQE-RRKQQLKRDQEEERRERWLKLEEE 494
Query: 507 NPSLMKVPQPETVKVSRSS-----LTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEE 561
+ + + ++ + L R +E Q LR Q + + REQL EE
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE 554
Query: 562 ETANCKQVNPPTF-LDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPP 620
E ++ +++ D ++ + + Q + + E+ +
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEE 614
Query: 621 LSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR-SRK 679
+ E L ++ +E E +LK+ + R ++
Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ---RLKREEEEERLEQR 671
Query: 680 LSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALK 739
L + E A + E+ + K +L E EA + KV + +E +
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL-ESEADARQSKVYSRPRKQEGQR 730
Query: 740 KQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIE---- 795
++ ++ + ++ A R + E++ + R++L
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790
Query: 796 KERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV-LRAKTQSL 854
+E+ +L AE Q++ + L + + +Q + +++LQ +E+E + R + Q L
Sbjct: 791 REQRERQLRAE-ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 855 EADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKK---TTQLENELKEALAKIKEL---- 907
+ + + LQ + ++ + + + + L+ K+ T + L+E L K ++L
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE 909
Query: 908 -EMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
E + ++E+ +++ + E +E + L+ ++
Sbjct: 910 EEELQREEREKRRRQEQERQYREEEQLQQEE 940
Score = 41.5 bits (93), Expect = 0.030
Identities = 118/684 (17%), Positives = 253/684 (36%), Gaps = 36/684 (5%)
Query: 267 KEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQKV 326
+E+Q++ E +E + + E+ + LRR ++ K + + + Q +V
Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237
Query: 327 NELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMD 386
+ E + E ++ + E E + + + + Q+ +L + L E EE
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ 297
Query: 387 ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKAD 446
+ +++LR Q R +Q + EQ ++ ++ ER+
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR--------EQEERREQ 349
Query: 447 QLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEV--ALRLQRELAEANSKFT 504
QL +E+ E E++ ++ + +RE +++ EQ++ R ++ +L+RE +
Sbjct: 350 QLRREQ-EEERREQQLRREQEEERREQQLRR-EQQLRREQQLRREQQLRREQQLRREQQL 407
Query: 505 GSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLRNAEEETA 564
L + Q + R ++ Q R + L+RE + R EEET
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERR--EQRLKREQEERRDWLKREEETE 465
Query: 565 NCKQVNPPTFLDKQVMTDNIVT-CDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSI 623
+Q L + + + E E + + +E+ + +
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEE------RREQQERREQQLRREQEERREQRL 519
Query: 624 DKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEE---DNESLLLQLKKMATKARSRKL 680
+ EE + L + R EE + E +LK+ + R + L
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 681 SPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKK 740
+ ++ + +E+ E++ LE E+ L+R+ E E+ ++ LK
Sbjct: 580 KREEERRQQRLK--REQEERLEQRLKREEVE-RLEQEERREQRLKREEPEEERRQQLLKS 636
Query: 741 QVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDC 800
+ +E + + R +L + + E+E E E+E+
Sbjct: 637 EEQE--ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Query: 801 ERLHAELSLAQ---KKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEAD 857
ER+ + + Q + +S+ +Q +RQ Q ++ + Q E
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Query: 858 NEKLQTENKK----LQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQD 913
+ + Q E ++ Q KS R + L Q E +L+ + +E + ++
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE 814
Query: 914 EKSEKKVRFTEATKKETDTLKSKQ 937
E+ E++ R +KE L+ ++
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEE 838
Score = 41.1 bits (92), Expect = 0.039
Identities = 64/366 (17%), Positives = 153/366 (41%), Gaps = 18/366 (4%)
Query: 686 ANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKEL 745
A + +++ ++ +E + + + LLEL + +++ E QD+ +++ KE
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE-RQDRVFQEEEEKEW 246
Query: 746 TSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHA 805
+ + + K + +L EE ++ + E E+R++ E+E+ +RL
Sbjct: 247 RKRETVLRK----EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR 302
Query: 806 ELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTEN 865
E L +K+ + + + + +QQ +R+ Q +E + R + + E + Q E
Sbjct: 303 EQQLRRKQEEER-REQQEERREQQE---RREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEA 925
++ Q L+ + ++ + ++ QL E + L + ++L Q + E+++R +
Sbjct: 359 RREQQLRRE---QEEERREQQLRREQQLRRE--QQLRREQQLRRE-QQLRREQQLRREQQ 412
Query: 926 TKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTT 985
++E + +Q Q + ++ + ++
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 986 KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEK 1045
K QLK+ D E E E ++ ++ ++ + +L +E +E R + K E +
Sbjct: 473 KQQLKR---DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529
Query: 1046 NRLQTE 1051
RL++E
Sbjct: 530 QRLRSE 535
Score = 37.1 bits (82), Expect = 0.64
Identities = 106/613 (17%), Positives = 240/613 (39%), Gaps = 39/613 (6%)
Query: 338 DEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCEELMDENEDMKKELRD 397
D K+ L Q R+ E + P + Q + R + E E E + K+E +
Sbjct: 104 DGKESLLQDRRQEEDQRRFEPR-DRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLE 162
Query: 398 LXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCR---VLSFKLKKTERKADQLEQEKAE 454
++ +R+ Q + RR E+ +++C+ F ++ R+ + LE +
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222
Query: 455 HEKKLLEIVGGPDGMQRENRI-KELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKV 513
E+K + +R++R+ +E E++ R E LR + E + ++
Sbjct: 223 REEKQQQ------RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP---QRQRELQE 273
Query: 514 PQPETVKVSRSSLTRGGSQEDPAQ--LLRDLQDSLEREADLREQLRNAEEETANCKQVNP 571
+ + K+ R L R +E+ Q L R+ Q ++E + REQ E+ +Q
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 572 PTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQ 631
++Q+ + + E + + + +E+ + + E Q
Sbjct: 334 RR--EQQLRREQE---ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQ 388
Query: 632 FHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR-SRKLSPTPPANKLS 690
+ LR+ E QL++ + R +K +L
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448
Query: 691 IETANDND----EKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELT 746
E D E+ET+ + K L+ +++E R + +LE+++ +++ +E
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEER--RERWLKLEEEERREQQERREQQ 506
Query: 747 SKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAE 806
+ + + ++ + E+ +++ K+ EK + ER
Sbjct: 507 LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR 566
Query: 807 LSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQ-TEN 865
L Q++ + + R + Q+ LKR+ Q E + R + + LE + + Q +
Sbjct: 567 LKREQEERRDQLLKREEERRQQR---LKRE-QEERLEQRLKREEVERLEQEERREQRLKR 622
Query: 866 KKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKV-RFTE 924
++ + + + L+S++ + ++ + + E +E K +E ++E+ E+++ R E
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE-----EEERLEQRLKREHE 677
Query: 925 ATKKETDTLKSKQ 937
++E + + +Q
Sbjct: 678 EERREQELAEEEQ 690
Score = 36.3 bits (80), Expect = 1.1
Identities = 43/224 (19%), Positives = 97/224 (43%), Gaps = 15/224 (6%)
Query: 729 EELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK--LAEERVKVLEDEI 786
E+L ++++ L+++ +EL + + + L EER K E
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 787 D-EVRK--KLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ + RK KL +KE E Q++ K + L ++Q + +R+ + ++
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD------LNTKKTTQLENEL 897
R K + + + + L+ E +K +L + + R ++ L L ++ T+ EL
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 898 KEALAKIKEL----EMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ K +EL E + ++E +++ + E +E + L+ ++
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120
>AK092690-1|BAC03946.1| 243|Homo sapiens protein ( Homo sapiens
cDNA FLJ35371 fis, clone SKMUS2001740, highly similar to
TROPOMYOSIN ALPHA CHAIN, SKELETAL MUSCLE TYPE. ).
Length = 243
Score = 64.1 bits (149), Expect = 5e-09
Identities = 57/184 (30%), Positives = 92/184 (50%), Gaps = 12/184 (6%)
Query: 760 NTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK 819
N R K AEER K LEDE+ ++KKL E + +R L+ A +K +
Sbjct: 18 NALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDRAQERLATALQKLEE--A 75
Query: 820 SRSLDASDQ-----QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNA 874
++ D S++ +N LK + ++ QE + AK + EAD K + +KL +++
Sbjct: 76 EKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD-RKYEEVARKLVIIEGD 134
Query: 875 KSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEK-SEKKVRFTEATKKETDTL 933
R+++ +L K ++LE ELK +K LE Q EK S+K+ ++ E K TD L
Sbjct: 135 LE-RTEERAELAESKCSELEEELKNVTNNLKSLE--AQAEKYSQKEDKYEEEIKILTDKL 191
Query: 934 KSKQ 937
K +
Sbjct: 192 KEAE 195
Score = 40.3 bits (90), Expect = 0.069
Identities = 44/227 (19%), Positives = 92/227 (40%), Gaps = 20/227 (8%)
Query: 1506 EKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERA--RLNARLDQRERELRAANDRR 1563
E+ E ++++ +A++Q++L G E++RA RL L + E +AA++
Sbjct: 24 EQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDRAQERLATALQKLEEAEKAADESE 83
Query: 1564 DVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXXIEQSEKARK 1623
++ + + I +E++E+ +
Sbjct: 84 RGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEE--R 141
Query: 1624 AEITDTK-TRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNGDKSA 1682
AE+ ++K + E ++ + + LKSL Q ++ ++ D Y++ ++ + E
Sbjct: 142 AELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKE-------- 193
Query: 1683 RIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTEL 1729
+ T E VA LE+ + LEDEL +L ++ EL
Sbjct: 194 -------AETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEEL 233
Score = 36.3 bits (80), Expect = 1.1
Identities = 35/136 (25%), Positives = 62/136 (45%), Gaps = 13/136 (9%)
Query: 970 KSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKEIDE 1029
K + + + L T LQ + E E V++N L +E + E+ E
Sbjct: 52 KGTEDELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEE-------KMELQE 104
Query: 1030 IRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKT 1089
I+ K +K+ +E E +R E+A+ + +EGD + + + E++ S L + K
Sbjct: 105 IQLKEAKHIAE---EADRKYEEVARKLVI---IEGDLERTEERAELAESKCSELEEELKN 158
Query: 1090 LTEEMKNREAQINKLS 1105
+T +K+ EAQ K S
Sbjct: 159 VTNNLKSLEAQAEKYS 174
Score = 34.3 bits (75), Expect = 4.5
Identities = 43/238 (18%), Positives = 105/238 (44%), Gaps = 13/238 (5%)
Query: 280 VDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL-KLQQKVNELTTHNEDLRD 338
++ ++K+ + ++ +K + L R + K RS ++ +L +L ++L
Sbjct: 2 MEAIKKKMQMLKLDKENAL-DRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDR 60
Query: 339 EKKHLTQKIREIESELETRPSTEAQTRQIEQL----RAKLLAAETLCEELMDENEDMKKE 394
++ L ++++E + +E + IE K+ E +E E+ ++
Sbjct: 61 AQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 120
Query: 395 LRDLXXXXXXMQDNFR--EDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQEK 452
++ ++ + E++A+ S ELE+ +KN ++ LK E +A++ Q++
Sbjct: 121 YEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQAEKYSQKE 177
Query: 453 AEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSL 510
++E+++ + + E R + E+ VA+ + L+ EL K+ + L
Sbjct: 178 DKYEEEIKILT--DKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEEL 233
Score = 33.5 bits (73), Expect = 7.9
Identities = 32/160 (20%), Positives = 67/160 (41%), Gaps = 7/160 (4%)
Query: 1403 KNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKY 1462
K + ELA ++ KLK E +R+ Q+ EE K + S K
Sbjct: 38 KQLEDELAAMQKKLKGTEDELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDE 97
Query: 1463 ELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEM 1522
E +E + + K + E+A + V ++L G+++ +E+ + + + E+
Sbjct: 98 EKMELQEIQLKEAKHI-AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL 156
Query: 1523 QNSIASLQERLCGGGWEVERARLNARLDQRERELRAANDR 1562
+N +L+ E + + + + D+ E E++ D+
Sbjct: 157 KNVTNNLK------SLEAQAEKYSQKEDKYEEEIKILTDK 190
>BC111801-1|AAI11802.1| 703|Homo sapiens ROCK2 protein protein.
Length = 703
Score = 63.7 bits (148), Expect = 6e-09
Identities = 84/378 (22%), Positives = 165/378 (43%), Gaps = 32/378 (8%)
Query: 727 KVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEI 786
+++ ++Q E + + K ++++ K ++ KL EER L+ ++
Sbjct: 8 QLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERT--LKQKV 65
Query: 787 DEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASV 846
+ + L+E E+ C L +L +Q+K L+K + + D +N+ LK IEQE
Sbjct: 66 ENL---LLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLK-----IEQETQK 117
Query: 847 LRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKE 906
L+ +++ T + LK + + ++L K+ +L E ++A ++KE
Sbjct: 118 RCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLE-KQNAELRKERQDADGQMKE 176
Query: 907 LEMICQDEKSEKKVRFTEATK-KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLK 965
L+ + E+ + T+ + KE K+K Q + K
Sbjct: 177 LQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTK 236
Query: 966 DDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEK 1025
D+++ + ++ +D L+ +K++++L EI EM K +E+T K
Sbjct: 237 ADSEQLARSIAEEQYSD----LEKEKIMKEL--EIKEMMARHK------QELTEKDATIA 284
Query: 1026 EIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLE--GDKDVFANKYKALENENSNL 1083
++E L+ + + NEK L KLKDV +L D+++ A KA + E L
Sbjct: 285 SLEETNRTLTSDVANLANEKEELNN---KLKDVQEQLSRLKDEEISAAAIKA-QFEKQLL 340
Query: 1084 SNQCKTLTEEMKNREAQI 1101
+ +TL + N+ A+I
Sbjct: 341 TE--RTLKTQAVNKLAEI 356
Score = 57.2 bits (132), Expect = 6e-07
Identities = 85/413 (20%), Positives = 180/413 (43%), Gaps = 38/413 (9%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRC--ERVEKEKSDILLRRLANIDTANKYTTGRSSE 318
L D N K Y+ E + + + K+ ER K+K + LL A K + +
Sbjct: 30 LADKN-KIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLE------AEKRCSLLDCD 82
Query: 319 VLKLQQKVNELTTHNEDLRDEKKHLTQKI-REIESELETRPSTEAQTRQIEQLR--AKLL 375
+ + QQK+NEL + L ++ ++LT KI +E + T+ + QT+Q+ L+ K L
Sbjct: 83 LKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQL 142
Query: 376 AAET--LCEELMD---ENEDMKKELRDLXXXXXXMQDNFREDQADEYSSL-RRELEQTIK 429
E L E M+ +N +++KE +D +QD +Q +S+L + ++ + +
Sbjct: 143 KQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ--YFSTLYKTQVRELKE 200
Query: 430 NCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEV- 488
C + K+ ++K +L+ E+ +L + D Q I E + ++
Sbjct: 201 ECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIM 260
Query: 489 -ALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLE 547
L ++ +A + T + ++ + + + +LT D A L + ++
Sbjct: 261 KELEIKEMMARHKQELTEKDATIASLEE------TNRTLT-----SDVANLANEKEELNN 309
Query: 548 READLREQLRNAEEETANCKQVNPPTFLDKQVMTD-NIVTCDIHESETVTNSIQNKMIHA 606
+ D++EQL ++E + + +KQ++T+ + T +++ + N + +
Sbjct: 310 KLKDVQEQLSRLKDEEISAAAIKAQ--FEKQLLTERTLKTQAVNKLAEIMNR-KEPVKRG 366
Query: 607 ASTPSSKEKSDSPPLSID-KTTEETQFHFDLPYLSIFNHMAANNLRKTAARVE 658
T +++ ++ L ++ K+ E + Y N M A ++ R+E
Sbjct: 367 NDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIE 419
Score = 44.4 bits (100), Expect = 0.004
Identities = 94/426 (22%), Positives = 183/426 (42%), Gaps = 74/426 (17%)
Query: 1374 ENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITEL 1433
E + LD DL+ ++K++ + KDV N+D TLK +EQ + +L
Sbjct: 73 EKRCSLLDCDLKQSQQKINEL--LKQKDVLNEDVRNLTLK-----IEQETQKRCLTQNDL 125
Query: 1434 KQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKE 1493
K + ++ V L+ S EK +L +E + + + ++ +EK+ A+ ++KE
Sbjct: 126 KMQTQQ-VNTLKMS---EK----------QLKQENNHLMEMKMNLEKQNAE-----LRKE 166
Query: 1494 LSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRE 1553
A G++K LQ++L E KT+ + L+E C E+ +L L Q++
Sbjct: 167 RQDADGQMKELQDQLEAEQYFSTLYKTQ----VRELKEE-C-----EEKTKLGKELQQKK 216
Query: 1554 RELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXX 1613
+EL+ D RD L D E++++
Sbjct: 217 QELQ---DERDSL--------AAQLEITLTKADSEQLAR--SIAEEQYSDLEKEKIMKEL 263
Query: 1614 XIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMA 1673
I++ K E+T+ + + ++ + ++L + V+ E++ L+ Q+ ++
Sbjct: 264 EIKEMMARHKQELTEK----DATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLS 319
Query: 1674 EIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEK 1733
+K+ + SA +I + E++ + L Q V ++L E ++ K E V
Sbjct: 320 RLKDEEISAA----AIKAQFEKQLLTERTLKTQAV----NKLAE--IMNRK---EPVKRG 366
Query: 1734 SSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETSTLAR 1793
+ +VR E ++R E L S R ++ T+ + + KE +E Q + E S +
Sbjct: 367 NDTDVRRKEKENRKLHME----LKSEREKL----TQQMIKYQKELNEMQAQIAEESQIRI 418
Query: 1794 DLRQTL 1799
+L+ TL
Sbjct: 419 ELQMTL 424
Score = 44.0 bits (99), Expect = 0.006
Identities = 61/292 (20%), Positives = 121/292 (41%), Gaps = 21/292 (7%)
Query: 1253 DLKADYE--NKITSLESTIAAKDVHIKQLEDAL-RQTTNDKYDEATSPVEMVEMRXXXXX 1309
DLK + N + E + ++ H+ +++ L +Q + + + +M E++
Sbjct: 124 DLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEA 183
Query: 1310 XXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXX 1369
+ ++ K E+ E ++ K E+ Q K +L +
Sbjct: 184 EQYFSTLYKTQVRELK---EECEEKTKLGK-ELQQKKQELQDERDSLAAQLEITLTKADS 239
Query: 1370 SSYWENKAKELDTDLQSER--KKLD--RMRIAHDKDVKNKDAELATLKGKLKILEQNSGA 1425
+ A+E +DL+ E+ K+L+ M H +++ KDA +A+L+ + L +
Sbjct: 240 EQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVAN 299
Query: 1426 GAKRITELKQEYEETVKKL------EHSLALEKAEYEELTGKYELLEEEHVVTKARLTVE 1479
A EL + ++ ++L E S A KA++E+ L+ + V A +
Sbjct: 300 LANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNR 359
Query: 1480 KEQAQG----ELLHVQKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIA 1527
KE + ++ +KE E+K+ +EKL + + E EMQ IA
Sbjct: 360 KEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIA 411
Score = 42.7 bits (96), Expect = 0.013
Identities = 54/295 (18%), Positives = 132/295 (44%), Gaps = 27/295 (9%)
Query: 648 NNLRKTAARVEEDNESLL---LQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDE 704
N L+ + +++++N L+ + L+K + R + +L + + +
Sbjct: 133 NTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYK 192
Query: 705 ADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
E+K E + L++K +EL+ ++++L Q++ +T T A S AR
Sbjct: 193 TQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLE--------ITLTKADSEQLAR 244
Query: 765 RSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLD 824
+ L E+ K++++ E+++ + +++ A ++ ++ +TL +
Sbjct: 245 SIAEEQYSDL--EKEKIMKEL--EIKEMMARHKQELTEKDATIASLEETNRTLTSDVANL 300
Query: 825 ASDQQNV-----DLKRQLQVIEQE---ASVLRA--KTQSLEADNEKLQTENKKLQLLKNA 874
A++++ + D++ QL ++ E A+ ++A + Q L K Q NK +++
Sbjct: 301 ANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRK 360
Query: 875 KSLRSDKALDL--NTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
+ ++ D+ K+ +L ELK K+ + + Q E +E + + E ++
Sbjct: 361 EPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQ 415
Score = 37.9 bits (84), Expect = 0.37
Identities = 43/196 (21%), Positives = 87/196 (44%), Gaps = 19/196 (9%)
Query: 1221 RLSIELTSEKDELQARFIKTES------KFITLEAEMRDLKADYENKITSLESTIAAKDV 1274
+L I LT E AR I E + I E E++++ A ++ ++T ++TIA+ +
Sbjct: 229 QLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEE 288
Query: 1275 HIKQLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEKTEAE 1334
+ L + N+K +E + ++ V+ + +E++ A IK + E +
Sbjct: 289 TNRTLTSDVANLANEK-EELNNKLKDVQEQ--------LSRLKDEEISAAAIKAQ-FEKQ 338
Query: 1335 SSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRM 1394
+ Q + LA++ N E + ++L +L+SER+KL +
Sbjct: 339 LLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRK---EKENRKLHMELKSEREKLTQQ 395
Query: 1395 RIAHDKDVKNKDAELA 1410
I + K++ A++A
Sbjct: 396 MIKYQKELNEMQAQIA 411
Score = 37.1 bits (82), Expect = 0.64
Identities = 35/182 (19%), Positives = 79/182 (43%), Gaps = 6/182 (3%)
Query: 1619 EKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEIKNG 1678
E+ K ++ + E + + + +LK +++ +++D + E + +I+
Sbjct: 58 ERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKD---VLNEDVRNLTLKIEQE 114
Query: 1679 DKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELVSEKSSAEV 1738
+ + +N + ++ N + + E+Q+ + L E ++ K N EL E+ A+
Sbjct: 115 TQKRCLTQNDLKMQTQQV--NTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADG 172
Query: 1739 RLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKE-RDEQQRLLQETSTLARDLRQ 1797
++ E+Q +L + L + R + KE + ++Q L E +LA L
Sbjct: 173 QMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEI 232
Query: 1798 TL 1799
TL
Sbjct: 233 TL 234
Score = 34.3 bits (75), Expect = 4.5
Identities = 33/155 (21%), Positives = 63/155 (40%), Gaps = 7/155 (4%)
Query: 1616 EQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQKSMAEI 1675
E KA KA + D YE + +K + ++ R + + +L A+K + +
Sbjct: 20 EAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLL 79
Query: 1676 KNGDKSARIHRNSISSTDE---EEYRNKVALLEQ--QVACLEDELCESRLLASKLNTELV 1730
K ++ N + + E+ RN +EQ Q CL + ++ ++NT +
Sbjct: 80 DCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQN--DLKMQTQQVNTLKM 137
Query: 1731 SEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAG 1765
SEK + M+ ++N ++ L R G
Sbjct: 138 SEKQLKQENNHLMEMKMNLEKQNAELRKERQDADG 172
>AB040942-1|BAA96033.1| 1326|Homo sapiens KIAA1509 protein protein.
Length = 1326
Score = 63.7 bits (148), Expect = 6e-09
Identities = 146/687 (21%), Positives = 283/687 (41%), Gaps = 62/687 (9%)
Query: 423 ELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKK--LLEIVGGPDGMQRENRIKELEQ 480
EL + ++ R S KL + ER+ QLE+EK E K LL+ +G ++ R++ Q
Sbjct: 6 ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALG-----KKSERLELSYQ 60
Query: 481 EVARSTEVALRLQRELAEANSKFTGSNPSLMKV-PQPETVKVSRSSLTRGGSQEDPAQLL 539
V+ LRLQ+ L ++ K L ++ + + ++ +L +Q + A+
Sbjct: 61 SVSAEN---LRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAE-- 115
Query: 540 RDLQDSLERE-ADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNS 598
+D + +LE+E A L + + E+E K++ L V+ D+ E E+
Sbjct: 116 KD-RKALEQEVAQLEKDKKLLEKE---AKRLWQQVELKDAVLDDSTAKLSAVEKESRALD 171
Query: 599 IQNKMIHAASTPSSKEKSDSPPLSIDKTTEE---TQFHFDLPYLSIFNHMAANNLRKTAA 655
+ A+ + + D+ L+ T T DL + + ++ L K +
Sbjct: 172 KELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQ 231
Query: 656 RVEED--NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLL 713
+E+ N LLLQ + + + L E N++ K T A E +L
Sbjct: 232 ELEKVGLNRELLLQEDDSGSDTKYKIL-----------EGRNESALK-TTLAMKEEKIVL 279
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNK 773
LE +E L R +LE + + LKK+ + L A ++ ++ K
Sbjct: 280 LEAQMEEKASLNR---QLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGK 336
Query: 774 LA-EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVD 832
A K E+ V+ + IE ER+ L AE K L+K + L + QNV
Sbjct: 337 EAWGPGHKEATMELLRVKDRAIELERNNAALQAE--------KQLLKEQ-LQHLETQNVT 387
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
Q+ ++++++ L+ +L+ KLQ EN L A + + + +T K T+
Sbjct: 388 FSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 447
Query: 893 LENELKEALAKIKELEMICQDEK-----SEKKVRFTEATKKETDTLKSKQXXXXXXXXXX 947
E+ ++ E + QD + E++ EA ++ LK+
Sbjct: 448 NESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKEL 507
Query: 948 XXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVM 1007
+A L+ + + ++ T+ + +++ +L+ + ++ +
Sbjct: 508 GERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELD-RVNFLHHQL 566
Query: 1008 KNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDK 1066
K +E+ A TK L+ ++ + +L++ + F K + QT L KL+
Sbjct: 567 KG---EYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISL----TKLDNHC 619
Query: 1067 DVFANKYKALENENSNLSNQCKTLTEE 1093
++ + LE EN +L +Q + L+++
Sbjct: 620 ELLSRLKGNLEEENHHLLSQIQLLSQQ 646
Score = 56.4 bits (130), Expect = 1e-06
Identities = 141/640 (22%), Positives = 250/640 (39%), Gaps = 51/640 (7%)
Query: 316 SSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLL 375
S+E L+LQQ + + + L E L + + + +LE AQ E+ R
Sbjct: 63 SAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRK--- 119
Query: 376 AAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRE---LEQTIKNCR 432
A E +L + + ++KE + L ++D +D + S++ +E L++ + CR
Sbjct: 120 ALEQEVAQLEKDKKLLEKEAKRL-WQQVELKDAVLDDSTAKLSAVEKESRALDKELARCR 178
Query: 433 VLSFKLKKTERKADQLEQEKAEHEKKLLE-----IVGGPDGMQRENRIKELEQEVAR-ST 486
+ KLK+ E+ L ++ H + L ++ Q + + +L QE+ +
Sbjct: 179 DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGL 238
Query: 487 EVALRLQRELAEANSKF---TGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQ 543
L LQ + + +++K+ G N S +K +K + L E+ A L R L+
Sbjct: 239 NRELLLQEDDSGSDTKYKILEGRNESALKTTL--AMKEEKIVLLE-AQMEEKASLNRQLE 295
Query: 544 DSLEREADLREQLRNAEEETANCK-QVNPPTFLDKQVMTDNIVTCDIHESETV-TNSIQN 601
L+ E LR + E + + P H+ T+ +++
Sbjct: 296 SELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKD 355
Query: 602 KMI----HAASTPSSKE--KSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAA 655
+ I + A+ + K+ K L T +Q L S F L+ A
Sbjct: 356 RAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQI-LTLQKQSAFLQEHNTTLQTQTA 414
Query: 656 RVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETD--EA---DPAEM 710
+++ +N +L Q A A+ L A + E+ E+ T EA D +
Sbjct: 415 KLQVENSTLSSQ--SAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHL 472
Query: 711 KLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSN------TTAR 764
L E E L R+ L+ L+ + KEL + + K A TT R
Sbjct: 473 GTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTER 532
Query: 765 RSL--TTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS 822
+L +N LA + L E+D V + + + E LHA K+ KT + +
Sbjct: 533 EALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAH----TKELKTSLNNAQ 588
Query: 823 LDASDQQN--VDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSD 880
L+ + Q +LK Q Q ++ + L + L L+ EN L S ++
Sbjct: 589 LELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQ 648
Query: 881 KALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKV 920
L+ N + Q E K+ + K+ L EK E+K+
Sbjct: 649 MLLEQNMENKEQYHEEQKQYIDKLNALRR--HKEKLEEKI 686
Score = 39.5 bits (88), Expect = 0.12
Identities = 58/217 (26%), Positives = 101/217 (46%), Gaps = 27/217 (12%)
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYW---- 1373
Q E N +++ EK E + L+ KS+ +L SS
Sbjct: 23 QMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQT 82
Query: 1374 -ENKAKELDTDLQSERKKLDRMRIAH------DKDVKNKDAELATLKGKLKILEQNSGAG 1426
E++ EL+ + Q+ R+ L+ +R+A+ +KD K + E+A L+ K+LE+ +
Sbjct: 83 LESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRL 142
Query: 1427 AKRITELKQE-YEETVKKL----EHSLALEK--AEYEELTGKYELLEEEH------VVTK 1473
+++ ELK +++ KL + S AL+K A + GK + LE+++ V
Sbjct: 143 WQQV-ELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVH 201
Query: 1474 AR-LTVEKEQAQGELLHVQKELSTALGEIKTLQEKLG 1509
AR LT +E E L Q +LS+ L ++ EK+G
Sbjct: 202 ARTLTTLREDLVLEKLKSQ-QLSSELDKLSQELEKVG 237
Score = 37.9 bits (84), Expect = 0.37
Identities = 65/320 (20%), Positives = 124/320 (38%), Gaps = 30/320 (9%)
Query: 1221 RLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYEN-KITSLESTIAAKDVHIKQL 1279
R ++E + E + ++ E+K + + E++D D K++++E A D + +
Sbjct: 118 RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARC 177
Query: 1280 EDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIKLEK--TEAESSA 1337
DA + + D ++ +++L K+K ++ +E + +
Sbjct: 178 RDAAGKLKELEKDNR-------DLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLS 230
Query: 1338 AKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIA 1397
+LE L +L E+ S L T L + +K+ +
Sbjct: 231 QELEKVGLNRELLLQEDDSGSDTKYKILEGRNES-------ALKTTLAMKEEKIVLLEAQ 283
Query: 1398 HDKDV---KNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLAL---- 1450
++ + ++EL LK + + L QN G G K +T + A
Sbjct: 284 MEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGH 343
Query: 1451 EKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT 1510
++A E L K +E E A L EK+ + +L H++ + T +I TLQ+
Sbjct: 344 KEATMELLRVKDRAIELER--NNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQK---- 397
Query: 1511 ESAAWNTEKTEMQNSIASLQ 1530
+SA T +Q A LQ
Sbjct: 398 QSAFLQEHNTTLQTQTAKLQ 417
>U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-coil
containing protein kinase p160ROCK protein.
Length = 1354
Score = 63.3 bits (147), Expect = 9e-09
Identities = 123/680 (18%), Positives = 281/680 (41%), Gaps = 45/680 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ + + ++Q+ Q D + ++C R K D +++ L + S++ K
Sbjct: 428 LQKTIYKLEEQLHNEMQLKDEMEQKC-RTSNIKLDKIMKELDEEGNQRRNLESTVSQIEK 486
Query: 322 ----LQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIEQLRAK 373
LQ ++NE E ++++++ ++ ++ +LE +++ ++ QL+ +
Sbjct: 487 EKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQ 546
Query: 374 LLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRV 433
L A L D ++K ++ ++ RE Q + L QT K+
Sbjct: 547 LEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQ-ERNRILENSKSQTDKDYYQ 605
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L L+ R + + + ++ + + ++ ++++E E + ++ L
Sbjct: 606 LQAILEAERRDRGHDSEMIGDLQARITSLQ--EEVKHLKHNLEKVEGERKEAQDM---LN 660
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
E N+ N L + Q +V+ +T+ D Q + + + E +
Sbjct: 661 HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKA-RLTDKHQSIEEAKSVAMCE--ME 717
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQV-MTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++L+ EE A K N ++KQ M D + + E +T + + +
Sbjct: 718 KKLK--EEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQ 775
Query: 613 KEKSDSPPLSIDKTTEETQFHFD-LPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKM 671
E+ + L + + F D L L N L + +E + L Q +
Sbjct: 776 LEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYR-- 833
Query: 672 ATKARSRKLSPTPPANKLS---IETANDNDEKETDEADPAEMKLLLEL-NEQEATVLRRK 727
+ + R+L A + +T ++E +E + +K + EL NE+E +
Sbjct: 834 GNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLD 893
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDE 785
+ E + + E L + + E + +T+ S + + R+ +T + ++ EE +L +
Sbjct: 894 LAETKAESEQLARGLLE--EQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKD 951
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL--QVIEQE 843
I+ +R++ E ++ E L +++ + +L A+ ++N++ +R L Q + +
Sbjct: 952 IEILRRENEELTEKMKKAEEEYKLEKEE-----EISNLKAAFEKNINTERTLKTQAVNKL 1006
Query: 844 ASVLRAKTQSLEA------DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENEL 897
A ++ K ++ D K + EN+KLQL N + + ++ + + K+ ++ +L
Sbjct: 1007 AEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQL 1066
Query: 898 KEALAKIKELEMICQDEKSE 917
E A EL+M ++S+
Sbjct: 1067 VEECAHRNELQMQLASKESD 1086
Score = 62.1 bits (144), Expect = 2e-08
Identities = 117/647 (18%), Positives = 251/647 (38%), Gaps = 43/647 (6%)
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E++ + ++D++ K+L E+ L + +S +K+ K L++ R + + + ++
Sbjct: 450 EQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKE-KMLLQHRINEYQRKAEQENEK 508
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+ V E E S L+ + + L+ ++ Q N+KL L+ +D L + +L
Sbjct: 509 RRNV-ENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEAND-LLRTESDTAVRLRK 566
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT-LKSKQXXXXXXXXXXXXXXXXX 954
E I +LE + + + +++ R E +K +TD Q
Sbjct: 567 SHTEMSKSISQLESL--NRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMI 624
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
QA + SL+++ K K + K + + + + M+ E E + + L+
Sbjct: 625 GDLQARITSLQEEV-KHLKHNLEKVEGE---RKEAQDMLNHSEKEKNNLEI-----DLNY 675
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQ-TEIAKLKDVNAKLEGDKDVFANKY 1073
K + + +LE+E++E K++K + T++ ++ + + ++ KL+ +++ +
Sbjct: 676 KLKSLQQRLEQEVNE--HKVTK--ARLTDKHQSIEEAKSVAMCEMEKKLKEEREA---RE 728
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
KA EN + QC L ++K + ++ L+ N ++ + +
Sbjct: 729 KA-ENRVVQIEKQCSMLDVDLKQSQQKLEHLTG---NKERMEDEVKNLTLQLEQESNKRL 784
Query: 1134 XXXXXXXXXXXQVDNYTKID----QDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEK 1189
+ DN ++ Q+ N LL+ ++ + ++
Sbjct: 785 LLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQD 844
Query: 1190 QLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARF----IKTESKFI 1245
QL + T + + + EL +EK+ L + K ES+ +
Sbjct: 845 QLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQL 904
Query: 1246 T---LEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE + +L + + + I KD + +LE+A T D E+ E
Sbjct: 905 ARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTE 964
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
++E++N K EK K Q + LA++ N
Sbjct: 965 KMKKAEEEYKLEK--EEEISNLKAAFEKNINTERTLK---TQAVNKLAEIMNRKDFKIDR 1019
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL 1409
E + ++L +L ER+K ++M + H K++ + A+L
Sbjct: 1020 KKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQL 1066
Score = 58.4 bits (135), Expect = 2e-07
Identities = 125/676 (18%), Positives = 278/676 (41%), Gaps = 56/676 (8%)
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVAL-RLQRELAE 498
+T AD+ QE + LE + + E ++K+ ++ R++ + L ++ +EL E
Sbjct: 415 RTSSNADKSLQESLQKTIYKLE-----EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDE 469
Query: 499 ANSKFTGSNPSLMKVPQPETVKVSR-SSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
++ ++ ++ + + + R + R QE+ + R++++ + + L++QL
Sbjct: 470 EGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKR--RNVENEV---STLKDQLE 524
Query: 558 NAEEETANCKQVNPP-TFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKS 616
+ ++ + N + N + L KQ+ N + ES+T ++ + + S E
Sbjct: 525 DLKKVSQNSQLANEKLSQLQKQLEEANDLLRT--ESDTAVR-LRKSHTEMSKSISQLESL 581
Query: 617 DSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKAR 676
+ ++ E ++ D Y + + A R+ E L ++ + + +
Sbjct: 582 NRELQERNRILENSKSQTDKDYYQLQAILEAE--RRDRGHDSEMIGDLQARITSLQEEVK 639
Query: 677 SRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKE 736
K N +E + + ++ + L ++LN + L+ + LEQ+
Sbjct: 640 HLK------HNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYK----LKSLQQRLEQEVN 689
Query: 737 ALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEK 796
K LT K S+ + + + + KL EER + ++ ++++
Sbjct: 690 EHKVTKARLTDKHQSIEEAKSVA-------MCEMEKKLKEER-----EAREKAENRVVQI 737
Query: 797 ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEA 856
E+ C L +L +Q+K + L ++ + +N+ L+ + + ++ KTQ+ EA
Sbjct: 738 EKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEA 797
Query: 857 DNEK-LQTENK-KLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAKIKELEMICQDE 914
DN K L+ + K ++ L AK L + L TK+ E +++E +++ +
Sbjct: 798 DNLKGLEKQMKQEINTLLEAKRLLEFELAQL-TKQYRGNEGQMRELQDQLEAEQYFSTLY 856
Query: 915 KSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKP 974
K++ K E +K + LK Q Q L K ++++ +
Sbjct: 857 KTQVKELKEEIEEKNRENLKKIQ---------ELQNEKETLATQLDLAETKAESEQLARG 907
Query: 975 RIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSK 1033
+ ++ +LT + KK EI + + + +T + L +E +E+ K
Sbjct: 908 LLEEQYFELTQ--ESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEK 965
Query: 1034 LSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGD-KDVFANKYKALENENSNLSNQCKTLTE 1092
+ K + E+ EK + + + N E K NK + N ++ K T+
Sbjct: 966 MKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQ 1025
Query: 1093 EMKNREAQINKLSADL 1108
+++ +E + KL +L
Sbjct: 1026 DLRKKEKENRKLQLEL 1041
Score = 48.8 bits (111), Expect = 2e-04
Identities = 121/627 (19%), Positives = 234/627 (37%), Gaps = 54/627 (8%)
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYV--VMKNAGLSGKEMTAKTKLEKE 1026
Q+S + I K L ++QLK +E +C + + +MK G + + LE
Sbjct: 425 QESLQKTIYKLEEQLHNEMQLKDEMEQ-KCRTSNIKLDKIMKELDEEGNQ---RRNLEST 480
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+ +I + + + + E K ++V ++ KD + K ++NS L+N+
Sbjct: 481 VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKV--SQNSQLANE 538
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQ---TTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
L++ K E + L + A L+ T MS +
Sbjct: 539 --KLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSK 596
Query: 1144 XQVD-NYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRI----EKQLSTRKDRV 1198
Q D +Y ++ ++ G ++ IGD K + EK RK+
Sbjct: 597 SQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQ 656
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEA--------- 1249
+ L + L L E +E + + K ++E
Sbjct: 657 DMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEM 716
Query: 1250 -----EMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK---YDEATSPVEMV 1301
E R+ + EN++ +E + DV +KQ + L T +K DE + +
Sbjct: 717 EKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQL 776
Query: 1302 EMRXXXXXXXXXXXXXQD-ELNNAKIKLEKTEAESSAAKLEMAQL----KSDLAKLENXX 1356
E Q E +N K LEK + LE +L + L K
Sbjct: 777 EQESNKRLLLQNELKTQAFEADNLK-GLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGN 835
Query: 1357 XXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKL 1416
Y+ K +L+ E ++ +R + ++++N+ LAT +L
Sbjct: 836 EGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLAT---QL 892
Query: 1417 KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL 1476
+ E + + L+++Y E ++ + + + + E + LEE + L
Sbjct: 893 DLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEE----ANSML 948
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAW----NTEKTEMQNSIASLQE 1531
T + E + E + +++ A E K +E++ AA+ NTE+T ++ L E
Sbjct: 949 TKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAE 1008
Query: 1532 RLCGGGWEVERARLNAR-LDQRERELR 1557
+ ++++R + N + L ++E+E R
Sbjct: 1009 IMNRKDFKIDRKKANTQDLRKKEKENR 1035
Score = 42.7 bits (96), Expect = 0.013
Identities = 88/442 (19%), Positives = 182/442 (41%), Gaps = 45/442 (10%)
Query: 1318 QDELNNAKIKLEKTEAESSAA-KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENK 1376
Q +L A L +TE++++ + ++ +++LE+ S +
Sbjct: 544 QKQLEEAN-DLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKD 602
Query: 1377 AKELDTDLQSERKKLDRMRIAHDKD-VKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+L L++ER+ DR HD + + + A + +L+ ++K L+ N E +
Sbjct: 603 YYQLQAILEAERR--DR---GHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQD 657
Query: 1436 EYEETVKKLEHSLALE-KAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
+ K+ +++L ++ + + L + E EH VTKARLT +K Q+ +++
Sbjct: 658 MLNHSEKE-KNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLT-DKHQS------IEEAK 709
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
S A+ E +++KL E A EK E N + + E+ C + L+ L Q ++
Sbjct: 710 SVAMCE---MEKKLKEEREA--REKAE--NRVVQI-EKQC--------SMLDVDLKQSQQ 753
Query: 1555 ELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXX 1614
+L ++ +E + K Q
Sbjct: 754 KLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINT 813
Query: 1615 IEQSEKARKAEITDTKTRY---EGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQ-- 1669
+ ++++ + E+ +Y EGQM ++D+L++ + ++ + K+ +E
Sbjct: 814 LLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRE 873
Query: 1670 --KSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNT 1727
K + E++N +K + ++ T E + LLE+Q EL + A+ N
Sbjct: 874 NLKKIQELQN-EKETLATQLDLAETKAESEQLARGLLEEQYF----ELTQESKKAASRNR 928
Query: 1728 ELVSEKSSAEVRLAEMQSRLNE 1749
+ +++K RL E S L +
Sbjct: 929 QEITDKDHTVSRLEEANSMLTK 950
Score = 36.3 bits (80), Expect = 1.1
Identities = 64/304 (21%), Positives = 120/304 (39%), Gaps = 28/304 (9%)
Query: 809 LAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKL 868
L+ P S + D S Q++ L++ + +E++ L + Q + +K +T N KL
Sbjct: 406 LSSANPNDNRTSSNADKSLQES--LQKTIYKLEEQ---LHNEMQLKDEMEQKCRTSNIKL 460
Query: 869 QLLKNAKSLRSDKALDLNTKKT-TQLENELKEALAKIKELEMICQDEKSEKKVRFTEATK 927
K K L + N + T +Q+E E +I E + + E +++ +
Sbjct: 461 D--KIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRR-----NVE 513
Query: 928 KETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKSLKD--DAQKSFKPRIPKKPTDLTT 985
E TLK + Q L+ D + R+ K T+++
Sbjct: 514 NEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSK 573
Query: 986 KLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKLEKE-IDEIRSKLSKNDSEFTNE 1044
+ +E L E+ E +++N+ K T K + + I E + +DSE +
Sbjct: 574 SIS---QLESLNRELQERNRILENS----KSQTDKDYYQLQAILEAERRDRGHDSEMIGD 626
Query: 1045 KNR----LQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNR-EA 1099
LQ E+ LK K+EG++ + E E +NL + ++ R E
Sbjct: 627 LQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQ 686
Query: 1100 QINK 1103
++N+
Sbjct: 687 EVNE 690
>BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated, coiled-coil
containing protein kinase 1 protein.
Length = 1354
Score = 63.3 bits (147), Expect = 9e-09
Identities = 123/680 (18%), Positives = 282/680 (41%), Gaps = 45/680 (6%)
Query: 262 VDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLK 321
+ + + ++Q+ Q D + ++C R K D +++ L + S++ K
Sbjct: 428 LQKTIYKLEEQLHNEMQLKDEMEQKC-RTSNIKLDKIMKELDEEGNQRRNLESTVSQIEK 486
Query: 322 ----LQQKVNELTTHNEDLRDEKKHLTQKIREIESELE----TRPSTEAQTRQIEQLRAK 373
LQ ++NE E ++++++ ++ ++++LE +++ ++ QL+ +
Sbjct: 487 EKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKNQLEDLKKVSQNSQLANEKLSQLQKQ 546
Query: 374 LLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRV 433
L A L D ++K ++ ++ RE Q + L QT K+
Sbjct: 547 LEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQ-ERNRILENSKSQTDKDYYQ 605
Query: 434 LSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQ 493
L L+ R + + + ++ + + ++ ++++E E + ++ L
Sbjct: 606 LQAILEAERRDRGHDSEMIGDLQARITSLQ--EEVKHLKHNLEKVEGERKEAQDM---LN 660
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
E N+ N L + Q +V+ +T+ D Q + + + E +
Sbjct: 661 HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKA-RLTDKHQSIEEAKSVAMCE--ME 717
Query: 554 EQLRNAEEETANCKQVNPPTFLDKQV-MTDNIVTCDIHESETVTNSIQNKMIHAASTPSS 612
++L+ EE A K N ++KQ M D + + E +T + + +
Sbjct: 718 KKLK--EEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQ 775
Query: 613 KEKSDSPPLSIDKTTEETQFHFD-LPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKM 671
E+ + L + + F D L L N L + +E + L Q +
Sbjct: 776 LEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYR-- 833
Query: 672 ATKARSRKLSPTPPANKLS---IETANDNDEKETDEADPAEMKLLLEL-NEQEATVLRRK 727
+ + R+L A + +T ++E +E + +K + EL NE+E +
Sbjct: 834 GNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLD 893
Query: 728 VEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA--EERVKVLEDE 785
+ E + + E L + + E + +T+ S + + R+ +T + ++ EE +L +
Sbjct: 894 LAETKAESEQLARGLLE--EQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKD 951
Query: 786 IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQL--QVIEQE 843
I+ +R++ E ++ E L +++ + +L A+ ++N++ +R L Q + +
Sbjct: 952 IEILRRENEELTERMKKAEEEYKLEKEE-----EISNLKAAFEKNINTERTLKTQAVNKL 1006
Query: 844 ASVLRAKTQSLEA------DNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENEL 897
A ++ K ++ D K + EN+KLQL N + + ++ + + K+ ++ +L
Sbjct: 1007 AEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQL 1066
Query: 898 KEALAKIKELEMICQDEKSE 917
E A EL+M ++S+
Sbjct: 1067 VEECAHRNELQMQLASKESD 1086
Score = 62.1 bits (144), Expect = 2e-08
Identities = 117/647 (18%), Positives = 251/647 (38%), Gaps = 43/647 (6%)
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKR 835
E++ + ++D++ K+L E+ L + +S +K+ K L++ R + + + ++
Sbjct: 450 EQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKE-KMLLQHRINEYQRKAEQENEK 508
Query: 836 QLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLEN 895
+ V E E S L+ + + L+ ++ Q N+KL L+ +D L + +L
Sbjct: 509 RRNV-ENEVSTLKNQLEDLKKVSQNSQLANEKLSQLQKQLEEAND-LLRTESDTAVRLRK 566
Query: 896 ELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDT-LKSKQXXXXXXXXXXXXXXXXX 954
E I +LE + + + +++ R E +K +TD Q
Sbjct: 567 SHTEMSKSISQLESL--NRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMI 624
Query: 955 XXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSG 1014
QA + SL+++ K K + K + + + + M+ E E + + L+
Sbjct: 625 GDLQARITSLQEEV-KHLKHNLEKVEGE---RKEAQDMLNHSEKEKNNLEI-----DLNY 675
Query: 1015 KEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQ-TEIAKLKDVNAKLEGDKDVFANKY 1073
K + + +LE+E++E K++K + T++ ++ + + ++ KL+ +++ +
Sbjct: 676 KLKSLQQRLEQEVNE--HKVTK--ARLTDKHQSIEEAKSVAMCEMEKKLKEEREA---RE 728
Query: 1074 KALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDCMXXXXXXXXXXX 1133
KA EN + QC L ++K + ++ L+ N ++ + +
Sbjct: 729 KA-ENRVVQIEKQCSMLDVDLKQSQQKLEHLTG---NKERMEDEVKNLTLQLEQESNKRL 784
Query: 1134 XXXXXXXXXXXQVDNYTKID----QDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRIEK 1189
+ DN ++ Q+ N LL+ ++ + ++
Sbjct: 785 LLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQD 844
Query: 1190 QLSTRKDRVTXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARF----IKTESKFI 1245
QL + T + + + EL +EK+ L + K ES+ +
Sbjct: 845 QLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQL 904
Query: 1246 T---LEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDKYDEATSPVEMVE 1302
LE + +L + + + I KD + +LE+A T D E+ E
Sbjct: 905 ARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTE 964
Query: 1303 MRXXXXXXXXXXXXXQDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENXXXXXXXX 1362
++E++N K EK K Q + LA++ N
Sbjct: 965 RMKKAEEEYKLEK--EEEISNLKAAFEKNINTERTLK---TQAVNKLAEIMNRKDFKIDR 1019
Query: 1363 XXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAEL 1409
E + ++L +L ER+K ++M + H K++ + A+L
Sbjct: 1020 KKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQL 1066
Score = 56.8 bits (131), Expect = 7e-07
Identities = 81/413 (19%), Positives = 173/413 (41%), Gaps = 22/413 (5%)
Query: 701 ETDEADPAEMKLLLELNEQEATVLRRKVE-ELEQDKEALKKQVKELTSKISSVTKTSAGS 759
E E + E + +L +E+E L + +L+ ++ L+++V E + +T
Sbjct: 646 EKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSI 705
Query: 760 NTTARRSLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIK 819
++ KL EER + ++ ++++ E+ C L +L +Q+K + L
Sbjct: 706 EEAKSVAMCEMEKKLKEER-----EAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTG 760
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEK-LQTENK-KLQLLKNAKSL 877
++ + +N+ L+ + + ++ KTQ+ EADN K L+ + K ++ L AK L
Sbjct: 761 NKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRL 820
Query: 878 RSDKALDLNTKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQ 937
+ L TK+ E +++E +++ + K++ K E +K + LK Q
Sbjct: 821 LEFELAQL-TKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQ 879
Query: 938 XXXXXXXXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE 997
Q L K ++++ + + ++ +LT + KK
Sbjct: 880 ---------ELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQ--ESKKAASRNR 928
Query: 998 CEIGEMYVVMKNAGLSGKEMTAKTK-LEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK 1056
EI + + + +T + L +E +E+ ++ K + E+ EK + +
Sbjct: 929 QEITDKDHTVSRLEEANSMLTKDIEILRRENEELTERMKKAEEEYKLEKEEEISNLKAAF 988
Query: 1057 DVNAKLEGD-KDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADL 1108
+ N E K NK + N ++ K T++++ +E + KL +L
Sbjct: 989 EKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLEL 1041
Score = 49.6 bits (113), Expect = 1e-04
Identities = 96/483 (19%), Positives = 191/483 (39%), Gaps = 27/483 (5%)
Query: 649 NLRKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPA 708
+L+KT ++EE + + +M K R+ + +L E N E+ +
Sbjct: 427 SLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELD-EEGNQRRNLESTVSQIE 485
Query: 709 EMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLT 768
+ K+LL+ E +RK E+ + + ++ +V L +++ + K S S A L+
Sbjct: 486 KEKMLLQHRINE---YQRKAEQENEKRRNVENEVSTLKNQLEDLKKVSQNSQL-ANEKLS 541
Query: 769 TNSNKLAE--ERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDAS 826
+L E + ++ D +RK E + +L + Q++ + L S+S +
Sbjct: 542 QLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKS--QT 599
Query: 827 DQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQL-LKNAKSLRSDKALDL 885
D+ L+ L+ ++ L+A LQ E K L+ L+ + R + L
Sbjct: 600 DKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDML 659
Query: 886 N--TKKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
N K+ LE +L K+K L+ + E +E KV T K ++K
Sbjct: 660 NHSEKEKNNLEIDLNY---KLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEM 716
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEM 1003
+A + ++ + Q S K+ L K E +E E+ +
Sbjct: 717 EKKLKEEREARE--KAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNK--ERMEDEVKNL 772
Query: 1004 YVVMKNAGLSGKEMTAKTKLEKEIDE------IRSKLSKNDSEFTNEKNRLQTEIAKLKD 1057
+ ++ S K + + +L+ + E + ++ + + K L+ E+A+L
Sbjct: 773 TLQLEQE--SNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTK 830
Query: 1058 VNAKLEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTT 1117
EG ++ +A + ++ Q K L EE++ + + K +L+N T
Sbjct: 831 QYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLAT 890
Query: 1118 MSD 1120
D
Sbjct: 891 QLD 893
Score = 46.4 bits (105), Expect = 0.001
Identities = 120/627 (19%), Positives = 233/627 (37%), Gaps = 54/627 (8%)
Query: 969 QKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYV--VMKNAGLSGKEMTAKTKLEKE 1026
Q+S + I K L ++QLK +E +C + + +MK G + + LE
Sbjct: 425 QESLQKTIYKLEEQLHNEMQLKDEMEQ-KCRTSNIKLDKIMKELDEEGNQ---RRNLEST 480
Query: 1027 IDEIRSKLSKNDSEFTNEKNRLQTEIAKLKDVNAKLEGDKDVFANKYKALENENSNLSNQ 1086
+ +I + + + + E K ++V ++ K+ + K ++NS L+N+
Sbjct: 481 VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKNQLEDLKKV--SQNSQLANE 538
Query: 1087 CKTLTEEMKNREAQINKLSADLKNATSLQ---TTMSDCMXXXXXXXXXXXXXXXXXXXXX 1143
L++ K E + L + A L+ T MS +
Sbjct: 539 --KLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSK 596
Query: 1144 XQVD-NYTKIDQDKNKLLKEVGDKTKKIGDXXXXXXXXXXXCKRI----EKQLSTRKDRV 1198
Q D +Y ++ ++ G ++ IGD K + EK RK+
Sbjct: 597 SQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQ 656
Query: 1199 TXXXXXXXXXXXQAVVLANTHRRLSIELTSEKDELQARFIKTESKFITLEA--------- 1249
+ L + L L E +E + + K ++E
Sbjct: 657 DMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEM 716
Query: 1250 -----EMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTNDK---YDEATSPVEMV 1301
E R+ + EN++ +E + DV +KQ + L T +K DE + +
Sbjct: 717 EKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQL 776
Query: 1302 EMRXXXXXXXXXXXXXQD-ELNNAKIKLEKTEAESSAAKLEMAQL----KSDLAKLENXX 1356
E Q E +N K LEK + LE +L + L K
Sbjct: 777 EQESNKRLLLQNELKTQAFEADNLK-GLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGN 835
Query: 1357 XXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKNKDAELATLKGKL 1416
Y+ K +L+ E ++ +R + ++++N+ LAT +L
Sbjct: 836 EGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLAT---QL 892
Query: 1417 KILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARL 1476
+ E + + L+++Y E ++ + + + + E + LEE + L
Sbjct: 893 DLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEE----ANSML 948
Query: 1477 TVEKEQAQGELLHVQKELSTALGEIK-TLQEKLGTESAAW----NTEKTEMQNSIASLQE 1531
T + E + E + + + A E K +E++ AA+ NTE+T ++ L E
Sbjct: 949 TKDIEILRRENEELTERMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAE 1008
Query: 1532 RLCGGGWEVERARLNAR-LDQRERELR 1557
+ ++++R + N + L ++E+E R
Sbjct: 1009 IMNRKDFKIDRKKANTQDLRKKEKENR 1035
Score = 42.7 bits (96), Expect = 0.013
Identities = 88/442 (19%), Positives = 182/442 (41%), Gaps = 45/442 (10%)
Query: 1318 QDELNNAKIKLEKTEAESSAA-KLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENK 1376
Q +L A L +TE++++ + ++ +++LE+ S +
Sbjct: 544 QKQLEEAN-DLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKD 602
Query: 1377 AKELDTDLQSERKKLDRMRIAHDKD-VKNKDAELATLKGKLKILEQNSGAGAKRITELKQ 1435
+L L++ER+ DR HD + + + A + +L+ ++K L+ N E +
Sbjct: 603 YYQLQAILEAERR--DR---GHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQD 657
Query: 1436 EYEETVKKLEHSLALE-KAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKEL 1494
+ K+ +++L ++ + + L + E EH VTKARLT +K Q+ +++
Sbjct: 658 MLNHSEKE-KNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLT-DKHQS------IEEAK 709
Query: 1495 STALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLDQRER 1554
S A+ E +++KL E A EK E N + + E+ C + L+ L Q ++
Sbjct: 710 SVAMCE---MEKKLKEEREA--REKAE--NRVVQI-EKQC--------SMLDVDLKQSQQ 753
Query: 1555 ELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXXXXXX 1614
+L ++ +E + K Q
Sbjct: 754 KLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINT 813
Query: 1615 IEQSEKARKAEITDTKTRY---EGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQ-- 1669
+ ++++ + E+ +Y EGQM ++D+L++ + ++ + K+ +E
Sbjct: 814 LLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRE 873
Query: 1670 --KSMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNT 1727
K + E++N +K + ++ T E + LLE+Q EL + A+ N
Sbjct: 874 NLKKIQELQN-EKETLATQLDLAETKAESEQLARGLLEEQYF----ELTQESKKAASRNR 928
Query: 1728 ELVSEKSSAEVRLAEMQSRLNE 1749
+ +++K RL E S L +
Sbjct: 929 QEITDKDHTVSRLEEANSMLTK 950
>AY354204-1|AAQ63889.2| 972|Homo sapiens retinoic acid induced 14
isoform protein.
Length = 972
Score = 63.3 bits (147), Expect = 9e-09
Identities = 116/561 (20%), Positives = 232/561 (41%), Gaps = 39/561 (6%)
Query: 305 IDTANKYTTGRSSEVLKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQT 364
I + K TT + + Q+ + +L E E+K L +++ +EL +TE +
Sbjct: 409 IHSLGKSTTDNDVRIQQPQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI-S 467
Query: 365 RQIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRREL 424
L KL ++ EE M E ++K+++ L DN+ S EL
Sbjct: 468 ENSSDLSQKLKETQSQYEEAMKEVLSVQKQMK-LGLVSPESMDNY---------SHFHEL 517
Query: 425 EQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVAR 484
T + VL L+ ++++ +++ E E+KL+E G + ++E E+ +
Sbjct: 518 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVE---REKGTVIKPPVEEYEEMKSS 574
Query: 485 STEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQD 544
V + +E A K+ + +M++ +T+K S+ + ED + + + D
Sbjct: 575 YCSVIENMNKEKAFLFEKYPEAQEGIMEL--KDTLK-SQMTQEASDEAEDMKEAMNRMID 631
Query: 545 SLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMI 604
L ++ QL +E A + L+ V + I + + +TN + K
Sbjct: 632 ELNKQVSELSQL--YKEAQAELEDYRKRKSLE-DVTAEYIHKAEHEKLMQLTNVSRAKAE 688
Query: 605 HAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESL 664
A S S+ L+ K + Q +SI H+ +TAA+ E+
Sbjct: 689 DALSEMKSQYSKVLNELTQLKQLVDAQKENS---VSITEHLQVITTLRTAAKEMEE---- 741
Query: 665 LLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADP-AEMKLLLELNEQEATV 723
++ + S+++ +L E A TD P + + L E E +V
Sbjct: 742 --KISNLKEHLASKEVEVLKLEKQLLEEKA-----AMTDAMVPRSSYEKLQSSLESEVSV 794
Query: 724 LRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLE 783
L K++E ++KE + +V ++ S++S V K + T +S N+L ++ + E
Sbjct: 795 LASKLKESVKEKEKVHSEVVQIRSEVSQV-KREKENIQTLLKSKEQEVNELLQKFQQAQE 853
Query: 784 D--EIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRS-LDASDQQNVDLKRQLQVI 840
+ E+ + + E D ++ E+S K K + S S L S + +QL+ +
Sbjct: 854 ELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEAL 913
Query: 841 EQEASVLRAKTQSLEADNEKL 861
+Q+ L+ + + ++++
Sbjct: 914 QQQVKQLQNQLAECKKQHQEV 934
Score = 51.6 bits (118), Expect = 3e-05
Identities = 70/420 (16%), Positives = 168/420 (40%), Gaps = 21/420 (5%)
Query: 714 LELNEQEATVLRRKVEELEQDKEALKKQVKELTSKI-----SSVTKTSAGSNTTARRSLT 768
L + E+E VL++ ++ ++ E K++V+EL K+ +V K + S
Sbjct: 517 LRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYC 576
Query: 769 TNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+ + +E+ + E + E ++ ++E + + + + + + +R +D ++
Sbjct: 577 SVIENMNKEKAFLFE-KYPEAQEGIMELKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 635
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKL-QTENKKLQLLKNAKSLRSDKALDLNT 887
Q +L + + + E R + + E + + E++KL L N +++ AL
Sbjct: 636 QVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDAL---- 691
Query: 888 KKTTQLENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETD---TLKSKQXXXXXXX 944
++++++ + L ++ +L+ + D + E V TE + T K +
Sbjct: 692 ---SEMKSQYSKVLNELTQLKQLV-DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLK 747
Query: 945 XXXXXXXXXXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMY 1004
+ L K + PR + + + ++ + L+ + E
Sbjct: 748 EHLASKEVEVLKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKE 807
Query: 1005 VVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSKNDSEFTNEKNRLQTEIAKLK---DVNAK 1061
V E++ + ++ I + + +E + + Q E+A++K + ++K
Sbjct: 808 KVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSK 867
Query: 1062 LEGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKLSADLKNATSLQTTMSDC 1121
LE DKD N+ + N L+ + + Q +L A + LQ +++C
Sbjct: 868 LEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 927
Score = 47.2 bits (107), Expect = 6e-04
Identities = 94/515 (18%), Positives = 207/515 (40%), Gaps = 23/515 (4%)
Query: 533 EDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES 592
+ P ++L+DLQ LE R+QL+ E ++ + V L+ +++N + D+ +
Sbjct: 424 QQPQEILQDLQKRLESSEAERKQLQ-VELQSRRAELV----CLNNTEISEN--SSDLSQK 476
Query: 593 ETVTNS-IQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNL- 650
T S + M S + P S+D + + +++ N L
Sbjct: 477 LKETQSQYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALE 536
Query: 651 --RKTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPA 708
+ +V E E L+ + K K + + IE N ++ E P
Sbjct: 537 ESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMN-KEKAFLFEKYPE 595
Query: 709 EMKLLLELNEQ-EATVLRRKVEELEQDKEALKKQVKELTSKISSVTK--TSAGSNTTARR 765
+ ++EL + ++ + + +E E KEA+ + + EL ++S +++ A + R
Sbjct: 596 AQEGIMELKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 655
Query: 766 SLTTNSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSL-D 824
+ + AE K +++ ++ K D L S K L + + L D
Sbjct: 656 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDA--LSEMKSQYSKVLNELTQLKQLVD 713
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
A + +V + LQVI + AK + N K +K++++LK K L +KA
Sbjct: 714 AQKENSVSITEHLQVITTLRTA--AKEMEEKISNLKEHLASKEVEVLKLEKQLLEEKAAM 771
Query: 885 LNTKKTTQLENELKEAL-AKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXX 943
+ +L+ +L +++ L ++ EK+ +E + ++ + K+
Sbjct: 772 TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ 831
Query: 944 XXXXXXXXXXXXXXQATLKSLKDDAQ-KSFKPRIPKKPTDLTTKL-QLKKMVEDLECEIG 1001
Q ++ ++ A+ K + K D K+ ++ K V L+ +
Sbjct: 832 TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALN 891
Query: 1002 EMYVVMKNAGLSGKEMTAKTKLEKEIDEIRSKLSK 1036
+ + + S ++ L++++ +++++L++
Sbjct: 892 SLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAE 926
Score = 43.2 bits (97), Expect = 0.010
Identities = 92/484 (19%), Positives = 186/484 (38%), Gaps = 46/484 (9%)
Query: 1318 QDELNNAKIKLEKTEAESSAAKLEMAQLKSDLAKLENX--XXXXXXXXXXXXXXSSYWEN 1375
Q+ L + + +LE +EAE ++E+ +++L L N S +E
Sbjct: 427 QEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSQYEE 486
Query: 1376 KAKELDTDLQSERK----KLDRM-RIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRI 1430
KE+ +Q + K + M +H +++ + E+ LK L+ + S +++
Sbjct: 487 AMKEV-LSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKV 545
Query: 1431 TELKQEYEETVKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHV 1490
EL+++ E K +E EYEE+ Y + E KA L + +AQ ++ +
Sbjct: 546 RELEEKLVEREKGTVIKPPVE--EYEEMKSSYCSVIENMNKEKAFLFEKYPEAQEGIMEL 603
Query: 1491 QKELSTALGEIKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVERARLNARLD 1550
+ L + + + ++ A N E+ ++ L + E+E R L+
Sbjct: 604 KDTLKSQM--TQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 661
Query: 1551 QRERELRAANDRRDVLEHHHDXXXXXXXXXXXXXXDYERVSKIQRXXXXXXXXXXXXXXX 1610
E + +++ + Y +V
Sbjct: 662 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKV------------------LN 703
Query: 1611 XXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYKQMLEAAQK 1670
++Q A+K E + + T + + T+R K + ++S + + + + +K
Sbjct: 704 ELTQLKQLVDAQK-ENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVLKLEK 762
Query: 1671 SMAEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESRLLASKLNTELV 1730
+ E K A + R+S Y + LE +V+ L +L ES K+++E+V
Sbjct: 763 QLLEEKAAMTDAMVPRSS--------YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVV 814
Query: 1731 SEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETST 1790
++R Q + + + LL S V L + + A +E E +R + +S
Sbjct: 815 ------QIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA-QEELAEMKRYAESSSK 867
Query: 1791 LARD 1794
L D
Sbjct: 868 LEED 871
Score = 42.7 bits (96), Expect = 0.013
Identities = 90/498 (18%), Positives = 208/498 (41%), Gaps = 30/498 (6%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLR-RLANIDTANKYTTGRSSEV 319
LV N E + L Q++ + + E KE + + +L + + E+
Sbjct: 458 LVCLNNTEISENSSDLSQKLKETQSQYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL 517
Query: 320 LKLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAET 379
++++N L ++ +E + +K+RE+E +L R +E+ + +
Sbjct: 518 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCS 577
Query: 380 LCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLK 439
+ E + E + ++ + ++D + E S ++++ + R++ +L
Sbjct: 578 VIENMNKEKAFLFEKYPEAQEGIMELKDTLKSQMTQEASDEAEDMKEAMN--RMID-ELN 634
Query: 440 KTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVA-LRLQRELAE 498
K + QL +E A+ E + + + E K +++ + T V+ + + L+E
Sbjct: 635 KQVSELSQLYKE-AQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE 693
Query: 499 ANSKFTGSNPSLMKVPQ-PETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
S+++ L ++ Q + K + S+T + Q++ L+ + + ++ E++
Sbjct: 694 MKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITTLRTAAK---EMEEKIS 744
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
N +E A+ K+V L+KQ++ + D + +Q+ + S +SK K +
Sbjct: 745 NLKEHLAS-KEVE-VLKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLK-E 801
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
S +E Q ++ + N+ +T + +E + LLQ + A + +
Sbjct: 802 SVKEKEKVHSEVVQIRSEVSQVK----REKENI-QTLLKSKEQEVNELLQKFQQAQEELA 856
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNE-QEATVLRRKVEELEQDKE 736
++KL ++ +K+ +E KL LN + + + Q E
Sbjct: 857 EMKRYAESSSKL-----EEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLE 911
Query: 737 ALKKQVKELTSKISSVTK 754
AL++QVK+L ++++ K
Sbjct: 912 ALQQQVKQLQNQLAECKK 929
Score = 34.3 bits (75), Expect = 4.5
Identities = 55/271 (20%), Positives = 108/271 (39%), Gaps = 12/271 (4%)
Query: 1231 DELQARFI-KTE-SKFITLEAEMRDLKADYENKITSLESTIAAKDVHIKQLEDALRQTTN 1288
+++ A +I K E K + L R D +++ S S + + +KQL DA ++ +
Sbjct: 661 EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV 720
Query: 1289 DKYDEATSPVEMVE-MRXXXXXXXXXXXXXQDELNNAKI---KLEKTEAESSAAKLEMAQ 1344
T ++++ +R ++ L + ++ KLEK E AA +
Sbjct: 721 S----ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVLKLEKQLLEEKAAMTDAMV 776
Query: 1345 LKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDRMRIAHDKDVKN 1404
+S KL++ S + K ++SE ++ R + +K+
Sbjct: 777 PRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 836
Query: 1405 KDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKAEYEELTGKYEL 1464
K+ E+ L K + Q A KR E + EE K + ++ E + +E
Sbjct: 837 KEQEVNELLQKFQ-QAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 895
Query: 1465 LEEEHVVTKARLTVEKEQAQGELLHVQKELS 1495
L +K R + + E Q ++ +Q +L+
Sbjct: 896 LSYSTSSSK-RQSQQLEALQQQVKQLQNQLA 925
>AK022532-1|BAB14081.1| 975|Homo sapiens protein ( Homo sapiens
cDNA FLJ12470 fis, clone NT2RM1000885, weakly similar to
HYPOTHETICAL 97.1 KD PROTEIN R05D3.4 IN CHROMOSOME III.
).
Length = 975
Score = 62.9 bits (146), Expect = 1e-08
Identities = 150/687 (21%), Positives = 274/687 (39%), Gaps = 72/687 (10%)
Query: 263 DSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKL 322
+S V + I+ L+ ++D +RKR +R+ + +++L R N Y G S +
Sbjct: 261 ESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLER--VNSKGYKVYGAGSSLYGGTI 318
Query: 323 QQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQLRAKLLAAETLCE 382
V + N +L + K+ ++ E+E + R E T Q E+L+ +L +A
Sbjct: 319 TINVRKFEEMNAELEENKELAQNRLCELE---KLRQDFEEVTTQNEKLKVELRSAVEQVV 375
Query: 383 ELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQT--IKNCRVLSFKLKK 440
+ E M+ + L ++ + E + + + Q I+ V K +
Sbjct: 376 KETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLR 435
Query: 441 TE--RKADQLEQEKAEHEKKLLEI--------VGGPDGMQRENRIKELEQEVARSTEVAL 490
TE + D L Q + E+E +E GP + + I L+ + L
Sbjct: 436 TEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVL 495
Query: 491 RLQRELAEANSKF------TGS----NPSLMKVP-------QPETVKVSRSSLTRGGSQE 533
R +R+L EA S +GS + S + P +P++ +S S SQE
Sbjct: 496 RYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQE 555
Query: 534 DPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESE 593
D A ++ +D ERE + RE+ R E E K+ +KQ + ESE
Sbjct: 556 D-ANEIKSKRDEEERERERREKEREREREREKEKERE----REKQ---------KLKESE 601
Query: 594 TVTNSIQNKMIHAASTPSSKEKSDSPPLSID-KTTEETQFHFDLPYLSIFNHMAANNLRK 652
+S ++K KE L I+ K +E+Q L L ++ K
Sbjct: 602 KERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKL-LLDMYRSAPKEQRDK 660
Query: 653 TAARVEEDN-----ESLLLQLKKMATKAR--SRKLSPTPPANKL-SIETANDNDEKETDE 704
E+ E L +LK + K + ++K++ K+ ++E + +K+
Sbjct: 661 VQLMAAEEKSKAELEDLRQRLKDLEDKEKKENKKMADEEALRKIRAVEEQIEYLQKKLAM 720
Query: 705 ADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTAR 764
A E LL E++ V + E++++ L +Q++E + SN
Sbjct: 721 AKQEEEALLSEMD-----VTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN-QIH 774
Query: 765 RSLTTNSNKLAEERVKVLEDEID---EVRKKLIEKERDCERL--HAELSLAQKKPKTLIK 819
+ L +LA++ V L+ ++D +V +KL EKE + E L + +
Sbjct: 775 KLLKEEKEELADQ-VLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMN 833
Query: 820 SRSLDASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQ--LLKNAKSL 877
R + Q DLK QL++ +++ + + EK K+ Q + + + L
Sbjct: 834 KRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKL 893
Query: 878 RSDKALDLNTKKTTQLENELKEALAKI 904
+ K D K L E+K+ A++
Sbjct: 894 ETTKKPDNVPKCDEILMEEIKDYKARL 920
Score = 43.2 bits (97), Expect = 0.010
Identities = 75/402 (18%), Positives = 162/402 (40%), Gaps = 35/402 (8%)
Query: 725 RRKVEELEQDKEALKKQVK----ELTSKISSVTKTSAGSNTTARRSLTTNS-----NKLA 775
+ +VE +E+D+ +L K+++ +L ++ V K ++L N N+
Sbjct: 417 QHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREM 476
Query: 776 EERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ-KKPKTLIKSRSL--DASDQQNVD 832
+ L++ +++ +++ +R ++L+ + + L++S+S D D+ +
Sbjct: 477 RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEP-AE 535
Query: 833 LKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQ 892
LK + + ++S +A + K E ++ + R +K + ++ +
Sbjct: 536 LKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERE--------RREKEREREREREKE 587
Query: 893 LENELKEALAKIKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXX 952
E E ++ K+KE E K ++K + + KKE + +K +
Sbjct: 588 KEREREKQ--KLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKL 645
Query: 953 XXXXXQATLKSLKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLE----CEIGEMYVVMK 1008
++ K +D Q K +L Q K +ED E ++ + + K
Sbjct: 646 LLDMYRSAPKEQRDKVQ--LMAAEEKSKAELEDLRQRLKDLEDKEKKENKKMADEEALRK 703
Query: 1009 NAGLSGKEMTAKTKLEKEIDEIRSKLSKND-----SEFTNEKN-RLQTEIAKLKDVNAKL 1062
+ + + KL E + LS+ D E E+N RL ++ + D N KL
Sbjct: 704 IRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKL 763
Query: 1063 EGDKDVFANKYKALENENSNLSNQCKTLTEEMKNREAQINKL 1104
++ +K L+ E L++Q TL ++ + + KL
Sbjct: 764 MSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKL 805
Score = 39.9 bits (89), Expect = 0.091
Identities = 67/331 (20%), Positives = 132/331 (39%), Gaps = 26/331 (7%)
Query: 1218 THRRLSIELTSEKDELQARFIKTESKFITLEAEMRDLKADYENKITSLESTIAAKDVHIK 1277
TH+ +EL E+DE+ K ++ I LE + ++ +YE E T+AA +
Sbjct: 415 THQH-QVELI-ERDEVSLHK-KLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANE-QAG 470
Query: 1278 QLEDALRQTTNDKYDEATSPVEMVEMRXXXXXXXXXXXXXQDELNNAKIK----LEKTEA 1333
+ +R + + +++ Q +LN +++ L ++++
Sbjct: 471 PINREMRHLISSLQNHNH------QLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQS 524
Query: 1334 ESSAAKLEMAQLKSDLAKLENXXXXXXXXXXXXXXXSSYWENKAKELDTDLQSERKKLDR 1393
+ K E A+LK D L + E K+K + + + ER++ +R
Sbjct: 525 STEDPKDEPAELKPDSEDLSSQSSASKASQEDAN------EIKSKRDEEERERERREKER 578
Query: 1394 MRIAHDKDVKNKDAELATLKGKLKILEQNSGAGAKRITELKQEYEETVKKLEHSLALEKA 1453
R + K ++ E LK K + + + +++ E +K+L+ L +
Sbjct: 579 EREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQE 638
Query: 1454 EYEE---LTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGEIKTLQEKLGT 1510
+E L Y +E K +L +E+++ EL +++ L + K +K+
Sbjct: 639 SQKEMKLLLDMYRSAPKEQ-RDKVQLMAAEEKSKAELEDLRQRLKDLEDKEKKENKKMAD 697
Query: 1511 ESAAWNTEKTEMQNSIASLQERLCGGGWEVE 1541
E A E Q I LQ++L E E
Sbjct: 698 EEALRKIRAVEEQ--IEYLQKKLAMAKQEEE 726
Score = 36.3 bits (80), Expect = 1.1
Identities = 57/271 (21%), Positives = 125/271 (46%), Gaps = 20/271 (7%)
Query: 661 NESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDE---ADPAEMKLLLELN 717
NESL QLK +AR+ L T ++ +E + DE + + +++ L
Sbjct: 393 NESL--QLKAHLDEARTL-LHGTRGTHQHQVELI-ERDEVSLHKKLRTEVIQLEDTLAQV 448
Query: 718 EQEATVLRRKVEE-LEQDKEA--LKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKL 774
+E +LR + E+ L +++A + ++++ L S + + G +R L + L
Sbjct: 449 RKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDL 508
Query: 775 AEERVK----VLEDE--IDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQ 828
+ R++ +L+ + ++ + + E + D E L ++ S ++ + + +S D+
Sbjct: 509 NKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKS--KRDE 566
Query: 829 QNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTK 888
+ + +R+ + E+E R K + E + +KL+ K+ K+ + + D +
Sbjct: 567 EERERERREKERERERE--REKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAE 624
Query: 889 KTTQLENELKEALAKIKELEMICQDEKSEKK 919
QL+ ELK+A KE++++ +S K
Sbjct: 625 IIKQLKIELKKAQESQKEMKLLLDMYRSAPK 655
>AB018345-1|BAA34522.2| 1578|Homo sapiens KIAA0802 protein protein.
Length = 1578
Score = 62.9 bits (146), Expect = 1e-08
Identities = 104/445 (23%), Positives = 184/445 (41%), Gaps = 71/445 (15%)
Query: 391 MKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKLKKTERKADQLEQ 450
++ EL +L M+D++ E+ + LRREL++ KNCR+L ++L+K E+K+ ++ +
Sbjct: 23 IQDELDELRAEMEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAE 82
Query: 451 EKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQREL---AEANSKFTGSN 507
G DG I+ LEQ++ + +V++RL EL E +K N
Sbjct: 83 ------------TGQVDG----ELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDEN 126
Query: 508 PSL----------MKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQLR 557
+L + Q E ++ SSL R ++E + QD ADLR QL+
Sbjct: 127 ETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDD---SADLRCQLQ 183
Query: 558 NAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVTNSIQNKMIHAASTPSSKEKSD 617
A+EE FL ++ M D E E + +P ++
Sbjct: 184 FAKEE----------AFLMRKKMAKLGREKDELEQEL---QKYKSLYGDVDSPLPTGEAG 230
Query: 618 SPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKKMATKARS 677
PP +T E + L + AN L + +E +N L +++ M + +
Sbjct: 231 GPP-----STREAELKLRLKLV----EEEANILGRKIVELEVENRGLKAEMEDM--RGQQ 279
Query: 678 RKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELNEQEATVLRRKVEELEQDKEA 737
+ P + SI T+ D E+ E++ L+ E+EA +LRR + E+E
Sbjct: 280 EREGPGRD-HAPSIPTSPFGDSLESS----TELRRHLQFVEEEAELLRRSISEIEDHNRQ 334
Query: 738 LKKQVKELTSK-------ISSVTKTSAGSNTTARRSLTTNSNKLAEERVKVLEDEIDEVR 790
L ++ + + + AG + L + +++E KVL ++
Sbjct: 335 LTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVL--KLQHEN 392
Query: 791 KKLIEKERDCERLHAELSLAQKKPK 815
L+ + C+ L A L L P+
Sbjct: 393 HALLSNIQRCD-LAAHLGLRAPSPR 416
Score = 55.2 bits (127), Expect = 2e-06
Identities = 106/439 (24%), Positives = 186/439 (42%), Gaps = 47/439 (10%)
Query: 472 ENRIKELEQEVARSTEVALRLQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGS 531
E R LE++V + E L+REL AN L K Q +++KV+ + G
Sbjct: 36 EMRDSYLEEDVYQLQE----LRRELDRANKNCRILQYRLRKAEQ-KSLKVAETGQVDG-- 88
Query: 532 QEDPAQLLRDLQDSLEREADLREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHE 591
E L +DL+ + + L +L+ EE+ A + N L +Q++ E
Sbjct: 89 -ELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENET--LRQQMI----------E 135
Query: 592 SETVTNSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLR 651
E ++QN++ SS ++ + + +K T DL F A +R
Sbjct: 136 VEISKQALQNELERLKE--SSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMR 193
Query: 652 KTAARVEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMK 711
K A++ + + L +L+K + SP P T T EA E+K
Sbjct: 194 KKMAKLGREKDELEQELQKYKSLYGDVD-SPLP--------TGEAGGPPSTREA---ELK 241
Query: 712 LLLELNEQEATVLRRKVEELEQDKEALKKQVKEL--TSKISSVTKTSAGSNTTARRSLTT 769
L L+L E+EA +L RK+ ELE + LK +++++ + + A S T+ +
Sbjct: 242 LRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSL 301
Query: 770 NSNKLAEERVKVLEDEIDEVRKKLIEKERDCERLHAELSLAQ----KKPKTLIKSRSLDA 825
S+ ++ +E+E + +R+ + E E +L ELS + ++P L + S A
Sbjct: 302 ESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGA 361
Query: 826 SDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKN----AKSLR-SD 880
L+ +L+ + S L K L+ +N L + ++ L + A S R SD
Sbjct: 362 GG--GAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSD 419
Query: 881 KALDLNTKKTTQLENELKE 899
D K++ E+ L +
Sbjct: 420 AESDAGKKESDGEESRLPQ 438
Score = 43.2 bits (97), Expect = 0.010
Identities = 67/309 (21%), Positives = 127/309 (41%), Gaps = 23/309 (7%)
Query: 266 VKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVLKLQQK 325
V+ QD+++ L+ E++ +R + + L R L D ANK + K +QK
Sbjct: 20 VRTIQDELDELRAEMEEMRDSYLEEDVYQLQELRREL---DRANKNCRILQYRLRKAEQK 76
Query: 326 VNELTTHNEDLRDEKKHLTQKIR-------EIESELETRPSTEAQTR-QIEQLRAKLLAA 377
++ + + + L Q ++ + EL+T A+ + E LR +++
Sbjct: 77 SLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEV 136
Query: 378 ETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFK 437
E + L +E E +K+ ++ +Q D+ + LR +L+ + ++ K
Sbjct: 137 EISKQALQNELERLKESSLKRRSTREMYKEKKTFNQ-DDSADLRCQLQFAKEEAFLMRKK 195
Query: 438 LKKTERKADQLEQEKAEHEKKLLEIVG----GPDGMQRENRIKELEQEVARSTEVALRLQ 493
+ K R+ D+LEQE +++ ++ G G R EL+ + E A L
Sbjct: 196 MAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILG 255
Query: 494 RELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLR 553
R++ E + G + E ++ + G P+ DSLE +LR
Sbjct: 256 RKIVELEVENRGLKAEM------EDMR-GQQEREGPGRDHAPSIPTSPFGDSLESSTELR 308
Query: 554 EQLRNAEEE 562
L+ EEE
Sbjct: 309 RHLQFVEEE 317
Score = 42.3 bits (95), Expect = 0.017
Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 7/127 (5%)
Query: 1673 AEIKNGDKSARIHRNSISSTDEEEYRNKVALLEQQVACLED---ELCESRLLASKLNTEL 1729
+ ++ GD S R+ ++ N+ L A LED EL E +L +
Sbjct: 782 SRVQIGDHSLRLQTADRGQPHKQVVENQ-QLFSAFKALLEDFRAELREDERARLRLQQQY 840
Query: 1730 VSEKSSAEVRLAEMQSRLNEYEEERLLSSGRARVAGLATRMELAWHKERDEQQRLLQETS 1789
S+K++ +V A ++ RL + EE+ + + G + + A KER+ Q+LL ++
Sbjct: 841 ASDKAAWDVEWAVLKCRLEQLEEK---TENKLGELGSSAESKGALKKEREVHQKLLADSH 897
Query: 1790 TLARDLR 1796
+L DLR
Sbjct: 898 SLVMDLR 904
>AL132765-6|CAC10587.1| 977|Homo sapiens ribosome binding protein 1
homolog 180kDa (dog) protein.
Length = 977
Score = 62.5 bits (145), Expect = 1e-08
Identities = 148/716 (20%), Positives = 287/716 (40%), Gaps = 59/716 (8%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
++ ++E + + +++ + + + + KE + + A K R E+
Sbjct: 264 ILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEIT 323
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ--LRAKLLAAE 378
+Q ++ ++ E ++ E + L KIR ++ +LE P+T+ Q E LR L A
Sbjct: 324 AVQARMQ--ASYREHVK-EVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 380
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ E +N ++ K ++L + + + DE R+ LE +L
Sbjct: 381 SQVES--KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQ--RKALEAKAAAFEKQVLQL 436
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ + R++++ Q++ + + L R + K EQ+ + E+ +LQ AE
Sbjct: 437 QASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQ-QQMAELHSKLQSSEAE 495
Query: 499 ANSK---FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
SK +G + L + + R + A+ +D+Q S + EAD ++Q
Sbjct: 496 VRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQAS-QAEAD-QQQ 553
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES-----ETVTNSIQNKMIHAASTP 610
R E E+ L + V + D+ E E + + Q S
Sbjct: 554 TRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLLSLT 613
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+KE+S+ I+ T E LP LS+ +A N + ++E +LL
Sbjct: 614 QAKEESEKQLCLIEAQTMEALLAL-LPELSV---LAQQNYTEWLQDLKEKGPTLLKHPPA 669
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELN-EQEATVLRRKV- 728
A + S S A + + D+ + A+ M L+ + E+E V R KV
Sbjct: 670 PA-EPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVG 728
Query: 729 --EELEQDKEALKKQVKELTSKISSVTKTS--AGSNTTARRSLTTNSNKLAEERVKVLED 784
EE Q K ++E+ K+ ++S +T+ + A +
Sbjct: 729 AAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAK 788
Query: 785 EIDEVRKKLIEKE-------RDCERLHAELSLAQKKPKTL-------------IKSRSLD 824
E+ +R+ L+E + + ++ EL+L +++ + S
Sbjct: 789 EVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAP 848
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
++Q V LK QL+ E + + Q L A+ E+ QT +LQ + + LR+ L+
Sbjct: 849 PAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ--EELEKLRTAGPLE 906
Query: 885 LNTKKTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFT-EATKKETDTLKSKQ 937
T+ ++LKE L K K+L ++ + ++ ++ T E +E DT+K Q
Sbjct: 907 ---SSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQ 959
Score = 42.3 bits (95), Expect = 0.017
Identities = 68/298 (22%), Positives = 120/298 (40%), Gaps = 32/298 (10%)
Query: 1441 VKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE 1500
+++L +A EKA+ K ++++ V + +T + + Q KE+ G+
Sbjct: 290 LRELNKEMAAEKAKAAAGEAK---VKKQLVAREQEITAVQARMQASYREHVKEVQQLQGK 346
Query: 1501 IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER------ARLNARLDQRER 1554
I+TLQE+L E+ NT+ +Q + L++ L +VE A+L L + +
Sbjct: 347 IRTLQEQL--ENGP-NTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSK 403
Query: 1555 EL-------RAANDRRDVLEHHHDXXXXXXXXXXXXXXDYE-----RVSKIQRXXXXXXX 1602
EL R +R LE + E R+ ++ R
Sbjct: 404 ELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQS 463
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
EQ + + AE+ E ++ + +EL LH Q+ R E
Sbjct: 464 SHASLRADAEKAQEQQQ--QMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAEN---S 518
Query: 1663 QMLEAAQKSMAEIKNGD-KSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESR 1719
Q+ E + A ++ G + A+ + S + D+++ R K LE QV+ LE E E R
Sbjct: 519 QLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKE--LESQVSGLEKEAIELR 574
>AL132765-4|CAH74034.1| 1410|Homo sapiens ribosome binding protein 1
homolog 180kDa (dog) protein.
Length = 1410
Score = 62.5 bits (145), Expect = 1e-08
Identities = 148/716 (20%), Positives = 287/716 (40%), Gaps = 59/716 (8%)
Query: 261 LVDSNVKEYQDQIEGLKQEVDILRKRCERVEKEKSDILLRRLANIDTANKYTTGRSSEVL 320
++ ++E + + +++ + + + + KE + + A K R E+
Sbjct: 697 ILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEIT 756
Query: 321 KLQQKVNELTTHNEDLRDEKKHLTQKIREIESELETRPSTEAQTRQIEQ--LRAKLLAAE 378
+Q ++ ++ E ++ E + L KIR ++ +LE P+T+ Q E LR L A
Sbjct: 757 AVQARMQ--ASYREHVK-EVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQAT 813
Query: 379 TLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSSLRRELEQTIKNCRVLSFKL 438
+ E +N ++ K ++L + + + DE R+ LE +L
Sbjct: 814 SQVES--KQNAELAKLRQELSKVSKELVEKSEAVRQDEQQ--RKALEAKAAAFEKQVLQL 869
Query: 439 KKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELEQEVARSTEVALRLQRELAE 498
+ + R++++ Q++ + + L R + K EQ+ + E+ +LQ AE
Sbjct: 870 QASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQ-QQMAELHSKLQSSEAE 928
Query: 499 ANSK---FTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQLLRDLQDSLEREADLREQ 555
SK +G + L + + R + A+ +D+Q S + EAD ++Q
Sbjct: 929 VRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQAS-QAEAD-QQQ 986
Query: 556 LRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHES-----ETVTNSIQNKMIHAASTP 610
R E E+ L + V + D+ E E + + Q S
Sbjct: 987 TRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLLSLT 1046
Query: 611 SSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAARVEEDNESLLLQLKK 670
+KE+S+ I+ T E LP LS+ +A N + ++E +LL
Sbjct: 1047 QAKEESEKQLCLIEAQTMEALLAL-LPELSV---LAQQNYTEWLQDLKEKGPTLLKHPPA 1102
Query: 671 MATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAEMKLLLELN-EQEATVLRRKV- 728
A + S S A + + D+ + A+ M L+ + E+E V R KV
Sbjct: 1103 PA-EPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVG 1161
Query: 729 --EELEQDKEALKKQVKELTSKISSVTKTS--AGSNTTARRSLTTNSNKLAEERVKVLED 784
EE Q K ++E+ K+ ++S +T+ + A +
Sbjct: 1162 AAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAK 1221
Query: 785 EIDEVRKKLIEKE-------RDCERLHAELSLAQKKPKTL-------------IKSRSLD 824
E+ +R+ L+E + + ++ EL+L +++ + S
Sbjct: 1222 EVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAP 1281
Query: 825 ASDQQNVDLKRQLQVIEQEASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALD 884
++Q V LK QL+ E + + Q L A+ E+ QT +LQ + + LR+ L+
Sbjct: 1282 PAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQ--EELEKLRTAGPLE 1339
Query: 885 LNTKKTTQLENELKEALAKIKEL--EMICQDEKSEKKVRFT-EATKKETDTLKSKQ 937
T+ ++LKE L K K+L ++ + ++ ++ T E +E DT+K Q
Sbjct: 1340 ---SSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQ 1392
Score = 42.3 bits (95), Expect = 0.017
Identities = 68/298 (22%), Positives = 120/298 (40%), Gaps = 32/298 (10%)
Query: 1441 VKKLEHSLALEKAEYEELTGKYELLEEEHVVTKARLTVEKEQAQGELLHVQKELSTALGE 1500
+++L +A EKA+ K ++++ V + +T + + Q KE+ G+
Sbjct: 723 LRELNKEMAAEKAKAAAGEAK---VKKQLVAREQEITAVQARMQASYREHVKEVQQLQGK 779
Query: 1501 IKTLQEKLGTESAAWNTEKTEMQNSIASLQERLCGGGWEVER------ARLNARLDQRER 1554
I+TLQE+L E+ NT+ +Q + L++ L +VE A+L L + +
Sbjct: 780 IRTLQEQL--ENGP-NTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSK 836
Query: 1555 EL-------RAANDRRDVLEHHHDXXXXXXXXXXXXXXDYE-----RVSKIQRXXXXXXX 1602
EL R +R LE + E R+ ++ R
Sbjct: 837 ELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQS 896
Query: 1603 XXXXXXXXXXXXIEQSEKARKAEITDTKTRYEGQMNTMRDELKSLHNQVSRFRRERDNYK 1662
EQ + + AE+ E ++ + +EL LH Q+ R E
Sbjct: 897 SHASLRADAEKAQEQQQ--QMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAEN---S 951
Query: 1663 QMLEAAQKSMAEIKNGD-KSARIHRNSISSTDEEEYRNKVALLEQQVACLEDELCESR 1719
Q+ E + A ++ G + A+ + S + D+++ R K LE QV+ LE E E R
Sbjct: 952 QLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKE--LESQVSGLEKEAIELR 1007
>AK025336-1|BAB15114.1| 963|Homo sapiens protein ( Homo sapiens
cDNA: FLJ21683 fis, clone COL09335. ).
Length = 963
Score = 62.5 bits (145), Expect = 1e-08
Identities = 106/549 (19%), Positives = 229/549 (41%), Gaps = 44/549 (8%)
Query: 310 KYTTGRSSEVLKLQQKVNE----LTTHNEDLRDEKKHLTQKIREIESEL---ETRPSTEA 362
+ G ++V++LQ+K++E T +E L T ++ ++ EL + P +
Sbjct: 59 RLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGEDT 118
Query: 363 QTR---QIEQLRAKLLAAETLCEELMDENEDMKKELRDLXXXXXXMQDNFREDQADEYSS 419
R ++E LR +L A + + L D + K ELR ++++ +
Sbjct: 119 SLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQ 178
Query: 420 LRRELEQTIKNCRVLSFKLKKTERKADQLEQEKAEHEKKLLEIVGGPDGMQRENRIKELE 479
+ + + V +KK +LE+E++ ++ + E QR + +++ E
Sbjct: 179 ILCQSKDEFAQNSVKENLMKK------ELEEERSRYQNLVKEY---SQLEQRYDNLRD-E 228
Query: 480 QEVARSTEVALR--LQRELAEANSKFTGSNPSLMKVPQPETVKVSRSSLTRGGSQEDPAQ 537
+ + T R + E++S + + S + + +V L +
Sbjct: 229 MTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFL 288
Query: 538 LLRDLQDSLEREAD-LREQLRNAEEETANCKQVNPPTFLDKQVMTDNIVTCDIHESETVT 596
L+ LE+E L+ QL E++ + Q PP TD + D + ++
Sbjct: 289 KLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPP-------QTD--IDLDPN-ADLAY 338
Query: 597 NSIQNKMIHAASTPSSKEKSDSPPLSIDKTTEETQFHFDLPYLSIFNHMAANNLRKTAAR 656
NS++ + + + + + ++ D+ T+ H S+ N L+
Sbjct: 339 NSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLL----LNQLKLAHEE 394
Query: 657 VEEDNESLLLQLKKMATKARSRKLSPTPPANKLSIETANDNDEKETDEADPAE-MKLLLE 715
+E E +L+ L+ A R+L+ ++ ++ N EK D+ D E + +
Sbjct: 395 LEVRKEEVLI-LRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQ 453
Query: 716 LNEQEATVLRRKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLA 775
N L+ + E E++ E LK Q++ L ++ +T + + + +
Sbjct: 454 TNRLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFG--VQ 511
Query: 776 EERVKVLEDEIDEVRKKLIEK-ERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLK 834
+E ++ + +D K+L+EK E++ +L +L + KK + L +++L S+++ +L
Sbjct: 512 QEISRLTNENLD--LKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELN 569
Query: 835 RQLQVIEQE 843
RQ+ V +E
Sbjct: 570 RQVTVQRKE 578
Score = 47.2 bits (107), Expect = 6e-04
Identities = 86/393 (21%), Positives = 162/393 (41%), Gaps = 39/393 (9%)
Query: 726 RKVEELEQDKEALKKQVKELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVK--VLE 783
R E L++ ++ +V +L KI K + + S+TT++ + ER+K ++
Sbjct: 52 RSAEHLKRLNVGMENKVVQLQRKIDEQNKEF--KTLSEQLSVTTSTYTMEVERLKKELVH 109
Query: 784 DEIDEVRKKLIEKERDCERLHAELSLAQKKPKTLIKSRSLDASDQQNVDLKRQLQVIEQE 843
+ + + + E L EL A + K L DA ++ +L++++ +EQE
Sbjct: 110 YQQSPGEDTSLRLQEEVESLRTELQRAHSERKILE-----DAHSREKDELRKRVADLEQE 164
Query: 844 ASVLRAKTQSLEADNEKLQTENKKLQLLKNAKSLRSDKALDLNTKKTTQLENELKEALAK 903
++L+ +EK Q N Q+L +K + ++ N K +LE E
Sbjct: 165 NALLK---------DEKEQLNN---QILCQSKDEFAQNSVKENLMKK-ELEEERSRYQNL 211
Query: 904 IKELEMICQDEKSEKKVRFTEATKKETDTLKSKQXXXXXXXXXXXXXXXXXXXXQATLKS 963
+KE + E+ +R K+T + T
Sbjct: 212 VKEYSQL---EQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDT--- 265
Query: 964 LKDDAQKSFKPRIPKKPTDLTTKLQLKKMVEDLECEIGEMYVVMKNAGLSGKEMTAKTKL 1023
+D Q+ + + K D+T L+L+K V +LE E ++ V ++ +E K+
Sbjct: 266 -EDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEK-----REQQDSKKV 319
Query: 1024 EKEIDEIRSKLSKN-DSEFTN-EKNRLQTEIAKLK-DVN--AKLEGDKDVFANKYKALEN 1078
+ E + L N D + + ++ L++E KLK D+N K D+ N +
Sbjct: 320 QAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPD 379
Query: 1079 ENSNLSNQCKTLTEEMKNREAQINKLSADLKNA 1111
S L NQ K EE++ R+ ++ L + +A
Sbjct: 380 SYSLLLNQLKLAHEELEVRKEEVLILRTQIVSA 412
Score = 42.3 bits (95), Expect = 0.017
Identities = 58/260 (22%), Positives = 113/260 (43%), Gaps = 30/260 (11%)
Query: 685 PANKLSIETANDNDEKETD-EADPAEMKLLLELNEQEATVLRRKVEELEQDKEALKKQVK 743
P S+ + + T+ + +E K+L + + +E LR++V +LEQ+ LK + +
Sbjct: 114 PGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKE 173
Query: 744 ELTSKISSVTKTSAGSNTTARRSLTTNSNKLAEERVKV---------LEDEIDEVRKKL- 793
+L ++I +K N+ + +L EER + LE D +R ++
Sbjct: 174 QLNNQILCQSKDEFAQNSVKENLM---KKELEEERSRYQNLVKEYSQLEQRYDNLRDEMT 230
Query: 794 IEKERDCERLHA--ELSLAQKKPKTLIKSRSL-DASD--QQNVDLKRQLQVIEQEASV-L 847
I K+ R + + SL I + + D D QQ ++ + ++ + L
Sbjct: 231 IIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKL 290
Query: 848 RAKTQSLEADNEKLQT--------ENKKLQLLKNAKSLRSDKALDL--NTKKTTQLENEL 897
+ + + LE + +KLQ ++KK+Q + D DL N+ K +LE+E
Sbjct: 291 QKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESEN 350
Query: 898 KEALAKIKELEMICQDEKSE 917
K+ + EL D+ ++
Sbjct: 351 KKLKNDLNELRKAVADQATQ 370
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.308 0.124 0.325
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 213,415,945
Number of Sequences: 224733
Number of extensions: 8175846
Number of successful extensions: 79377
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 435
Number of HSP's successfully gapped in prelim test: 2284
Number of HSP's that attempted gapping in prelim test: 46393
Number of HSP's gapped (non-prelim): 25706
length of query: 1982
length of database: 73,234,838
effective HSP length: 101
effective length of query: 1881
effective length of database: 50,536,805
effective search space: 95059730205
effective search space used: 95059730205
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (21.7 bits)
S2: 73 (33.5 bits)
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