Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002651-TA|BGIBMGA002651-PA|IPR013132|N-acetylneuraminic
acid synthase, N-terminal
(349 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC000008-1|AAH00008.1| 359|Homo sapiens N-acetylneuraminic acid... 321 2e-87
AL137073-4|CAI13886.1| 359|Homo sapiens N-acetylneuraminic acid... 321 2e-87
BC019315-1|AAH19315.1| 359|Homo sapiens N-acetylneuraminic acid... 320 5e-87
AK001659-1|BAA91818.1| 359|Homo sapiens protein ( Homo sapiens ... 320 5e-87
AF257466-1|AAF75261.1| 359|Homo sapiens N-acetylneuraminic acid... 319 1e-86
AL137073-5|CAI13887.1| 140|Homo sapiens N-acetylneuraminic acid... 122 1e-27
AL137073-6|CAI13888.1| 115|Homo sapiens N-acetylneuraminic acid... 93 1e-18
>BC000008-1|AAH00008.1| 359|Homo sapiens N-acetylneuraminic acid
synthase (sialic acid synthase) protein.
Length = 359
Score = 321 bits (789), Expect = 2e-87
Identities = 157/345 (45%), Positives = 214/345 (62%), Gaps = 1/345 (0%)
Query: 2 VEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKF 61
+E+++ +GG +PCFIIAE GQNHQGD GA C KFQK+ L KF
Sbjct: 3 LELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKF 62
Query: 62 TKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFL 121
+K LERPY + +SWGKTYGEHK HLEFS QYREL RYA+EVGI FTAS MD ++ +FL
Sbjct: 63 NRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFL 122
Query: 122 VNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLL 181
L VPF K+GSGD+NN +L+ A K P++IS+GM +K +Y I+ + FC L
Sbjct: 123 HELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFL 182
Query: 182 HCISAYPVPFEDCNLTVLQDYKNTF-DVPVGYSGQEXXXXXXXXXXXXXXXXXEKHITLD 240
C SAYP+ ED NL V+ +Y+ F D+P+GYSG E E+HITLD
Sbjct: 183 QCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLD 242
Query: 241 KSMKGTDHVCSLTPSEFQQLVRDVRVIEASLGTPIKKVVTSEIPCIDKLQKSLVMGSTKN 300
K+ KG+DH SL P E +LVR VR++E +LG+P K+++ E+ C +KL KS+V
Sbjct: 243 KTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIP 302
Query: 301 KGEILYPGDVKIKVAEPKGLNALHLEDVIYKTLVYDKKEDEPLNE 345
+G IL + +KV EPKG + +++ K ++ +ED+ + E
Sbjct: 303 EGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIME 347
>AL137073-4|CAI13886.1| 359|Homo sapiens N-acetylneuraminic acid
synthase (sialic acid synthase) protein.
Length = 359
Score = 321 bits (789), Expect = 2e-87
Identities = 157/345 (45%), Positives = 214/345 (62%), Gaps = 1/345 (0%)
Query: 2 VEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKF 61
+E+++ +GG +PCFIIAE GQNHQGD GA C KFQK+ L KF
Sbjct: 3 LELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKF 62
Query: 62 TKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFL 121
+K LERPY + +SWGKTYGEHK HLEFS QYREL RYA+EVGI FTAS MD ++ +FL
Sbjct: 63 NRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFL 122
Query: 122 VNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLL 181
L VPF K+GSGD+NN +L+ A K P++IS+GM +K +Y I+ + FC L
Sbjct: 123 HELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFL 182
Query: 182 HCISAYPVPFEDCNLTVLQDYKNTF-DVPVGYSGQEXXXXXXXXXXXXXXXXXEKHITLD 240
C SAYP+ ED NL V+ +Y+ F D+P+GYSG E E+HITLD
Sbjct: 183 QCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLD 242
Query: 241 KSMKGTDHVCSLTPSEFQQLVRDVRVIEASLGTPIKKVVTSEIPCIDKLQKSLVMGSTKN 300
K+ KG+DH SL P E +LVR VR++E +LG+P K+++ E+ C +KL KS+V
Sbjct: 243 KTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIP 302
Query: 301 KGEILYPGDVKIKVAEPKGLNALHLEDVIYKTLVYDKKEDEPLNE 345
+G IL + +KV EPKG + +++ K ++ +ED+ + E
Sbjct: 303 EGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIME 347
>BC019315-1|AAH19315.1| 359|Homo sapiens N-acetylneuraminic acid
synthase (sialic acid synthase) protein.
Length = 359
Score = 320 bits (786), Expect = 5e-87
Identities = 156/345 (45%), Positives = 214/345 (62%), Gaps = 1/345 (0%)
Query: 2 VEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKF 61
+E+++ +GG +PCFIIAE GQNHQGD GA C KFQK+ L KF
Sbjct: 3 LELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKF 62
Query: 62 TKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFL 121
+K L+RPY + +SWGKTYGEHK HLEFS QYREL RYA+EVGI FTAS MD ++ +FL
Sbjct: 63 NRKALDRPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFL 122
Query: 122 VNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLL 181
L VPF K+GSGD+NN +L+ A K P++IS+GM +K +Y I+ + FC L
Sbjct: 123 HELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFL 182
Query: 182 HCISAYPVPFEDCNLTVLQDYKNTF-DVPVGYSGQEXXXXXXXXXXXXXXXXXEKHITLD 240
C SAYP+ ED NL V+ +Y+ F D+P+GYSG E E+HITLD
Sbjct: 183 QCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLD 242
Query: 241 KSMKGTDHVCSLTPSEFQQLVRDVRVIEASLGTPIKKVVTSEIPCIDKLQKSLVMGSTKN 300
K+ KG+DH SL P E +LVR VR++E +LG+P K+++ E+ C +KL KS+V
Sbjct: 243 KTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIP 302
Query: 301 KGEILYPGDVKIKVAEPKGLNALHLEDVIYKTLVYDKKEDEPLNE 345
+G IL + +KV EPKG + +++ K ++ +ED+ + E
Sbjct: 303 EGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIME 347
>AK001659-1|BAA91818.1| 359|Homo sapiens protein ( Homo sapiens
cDNA FLJ10797 fis, clone NT2RP4000657, weakly similar to
SPORE COAT POLYSACCHARIDE BIOSYNTHESIS PROTEIN SPSE. ).
Length = 359
Score = 320 bits (786), Expect = 5e-87
Identities = 156/345 (45%), Positives = 214/345 (62%), Gaps = 1/345 (0%)
Query: 2 VEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKF 61
+E+++ +GG +PCFIIAE GQNHQGD GA C KFQK+ L KF
Sbjct: 3 LELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKF 62
Query: 62 TKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFL 121
+K L+RPY + +SWGKTYGEHK HLEFS QYREL RYA+EVGI FTAS MD ++ +FL
Sbjct: 63 NRKALDRPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFL 122
Query: 122 VNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLL 181
L VPF K+GSGD+NN +L+ A K P++IS+GM +K +Y I+ + FC L
Sbjct: 123 HELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFL 182
Query: 182 HCISAYPVPFEDCNLTVLQDYKNTF-DVPVGYSGQEXXXXXXXXXXXXXXXXXEKHITLD 240
C SAYP+ ED NL V+ +Y+ F D+P+GYSG E E+HITLD
Sbjct: 183 QCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGTKVLERHITLD 242
Query: 241 KSMKGTDHVCSLTPSEFQQLVRDVRVIEASLGTPIKKVVTSEIPCIDKLQKSLVMGSTKN 300
K+ KG+DH SL P E +LVR VR++E +LG+P K+++ E+ C +KL KS+V
Sbjct: 243 KTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIP 302
Query: 301 KGEILYPGDVKIKVAEPKGLNALHLEDVIYKTLVYDKKEDEPLNE 345
+G IL + +KV EPKG + +++ K ++ +ED+ + E
Sbjct: 303 EGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIME 347
>AF257466-1|AAF75261.1| 359|Homo sapiens N-acetylneuraminic acid
phosphate synthase protein.
Length = 359
Score = 319 bits (783), Expect = 1e-86
Identities = 156/345 (45%), Positives = 213/345 (61%), Gaps = 1/345 (0%)
Query: 2 VEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKF 61
+E+++ +GG +PCFIIAE GQNHQGD GA C KFQK+ L KF
Sbjct: 3 LELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKF 62
Query: 62 TKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFL 121
+K LERPY + +SWGKTYGEHK HLEFS QYREL RYA+EVGI FTAS MD ++ +FL
Sbjct: 63 NRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFL 122
Query: 122 VNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLL 181
L VPF K+GSGD+NN +L+ A K P++IS+GM +K +Y I+ + FC L
Sbjct: 123 HELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFL 182
Query: 182 HCISAYPVPFEDCNLTVLQDYKNTF-DVPVGYSGQEXXXXXXXXXXXXXXXXXEKHITLD 240
C SAYP+ ED NL V+ +Y+ F D+P+GYSG E E+HITLD
Sbjct: 183 QCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLD 242
Query: 241 KSMKGTDHVCSLTPSEFQQLVRDVRVIEASLGTPIKKVVTSEIPCIDKLQKSLVMGSTKN 300
K+ KG+DH SL P E +LVR VR++E +LG+P K+++ E+ C +KL KS+V
Sbjct: 243 KTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIP 302
Query: 301 KGEILYPGDVKIKVAEPKGLNALHLEDVIYKTLVYDKKEDEPLNE 345
+G IL + +KV EPK + +++ K ++ +ED+ + E
Sbjct: 303 EGTILTMDMLTVKVGEPKAYPPEDIFNLVGKKVLVTVEEDDTIME 347
>AL137073-5|CAI13887.1| 140|Homo sapiens N-acetylneuraminic acid
synthase (sialic acid synthase) protein.
Length = 140
Score = 122 bits (295), Expect = 1e-27
Identities = 55/130 (42%), Positives = 79/130 (60%), Gaps = 1/130 (0%)
Query: 151 PLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYPVPFEDCNLTVLQDYKNTF-DVP 209
P++IS+GM +K +Y I+ + FC L C SAYP+ ED NL V+ +Y+ F D+P
Sbjct: 11 PMVISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQPEDVNLRVISEYQKLFPDIP 70
Query: 210 VGYSGQEXXXXXXXXXXXXXXXXXEKHITLDKSMKGTDHVCSLTPSEFQQLVRDVRVIEA 269
+GYSG E E+HITLDK+ KG+DH SL P E +LVR VR++E
Sbjct: 71 IGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAELVRSVRLVER 130
Query: 270 SLGTPIKKVV 279
+LG+P K+++
Sbjct: 131 ALGSPTKQLL 140
>AL137073-6|CAI13888.1| 115|Homo sapiens N-acetylneuraminic acid
synthase (sialic acid synthase) protein.
Length = 115
Score = 93.5 bits (222), Expect = 1e-18
Identities = 42/99 (42%), Positives = 61/99 (61%), Gaps = 1/99 (1%)
Query: 192 EDCNLTVLQDYKNTF-DVPVGYSGQEXXXXXXXXXXXXXXXXXEKHITLDKSMKGTDHVC 250
ED NL V+ +Y+ F D+P+GYSG E E+HITLDK+ KG+DH
Sbjct: 1 EDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSA 60
Query: 251 SLTPSEFQQLVRDVRVIEASLGTPIKKVVTSEIPCIDKL 289
SL P E +LVR VR++E +LG+P K+++ E+ C +K+
Sbjct: 61 SLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKV 99
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.318 0.137 0.405
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 45,998,514
Number of Sequences: 224733
Number of extensions: 1742778
Number of successful extensions: 3187
Number of sequences better than 10.0: 7
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 3174
Number of HSP's gapped (non-prelim): 7
length of query: 349
length of database: 73,234,838
effective HSP length: 91
effective length of query: 258
effective length of database: 52,784,135
effective search space: 13618306830
effective search space used: 13618306830
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 66 (30.7 bits)
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