Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002645-TA|BGIBMGA002645-PA|IPR006025|Peptidase M,
neutral zinc metallopeptidases, zinc-binding site, IPR001590|Peptidase
M12B, ADAM/reprolysin
(622 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AL358817-5|CAI13857.1| 1226|Homo sapiens ADAM metallopeptidase w... 140 2e-32
AL355344-5|CAI41278.1| 1226|Homo sapiens ADAM metallopeptidase w... 140 2e-32
AF366351-1|AAL79814.1| 1159|Homo sapiens ADAMTS14 protein. 140 2e-32
AL358817-4|CAI13858.1| 1223|Homo sapiens ADAM metallopeptidase w... 138 7e-32
AL355344-4|CAI41277.1| 1223|Homo sapiens ADAM metallopeptidase w... 138 7e-32
AJ345098-1|CAC87943.1| 1223|Homo sapiens metalloprotease-disinte... 138 7e-32
AF358666-1|AAL40229.1| 1223|Homo sapiens a disintegrin-like and ... 138 7e-32
BC063283-1|AAH63283.1| 1221|Homo sapiens ADAM metallopeptidase w... 133 2e-30
AJ315734-1|CAC86015.1| 1072|Homo sapiens metalloprotease disinte... 130 2e-29
AB095949-1|BAC23125.1| 1021|Homo sapiens KIAA2029 protein protein. 130 2e-29
AJ311903-1|CAC83612.1| 1081|Homo sapiens ADAMTS18 protein protein. 127 1e-28
BC061631-1|AAH61631.1| 1686|Homo sapiens ADAM metallopeptidase w... 126 3e-28
AY327122-1|AAQ94616.1| 1686|Homo sapiens COMPase precursor protein. 126 3e-28
AF140675-1|AAD56358.1| 997|Homo sapiens zinc metalloprotease AD... 126 3e-28
BC131733-1|AAI31734.1| 1509|Homo sapiens ADAMTS12 protein protein. 122 3e-27
AJ250725-1|CAC20419.1| 1593|Homo sapiens a disintegrin-like and ... 122 3e-27
AJ003125-1|CAA05880.1| 1211|Homo sapiens procollagen I N-protein... 121 7e-27
DQ217943-1|ABB70740.1| 1095|Homo sapiens ADAM metallopeptidase w... 118 6e-26
AK131344-1|BAD18500.1| 502|Homo sapiens protein ( Homo sapiens ... 118 6e-26
AJ315735-1|CAC86016.1| 1095|Homo sapiens metalloprotease disinte... 118 6e-26
AY692424-1|AAW47397.1| 1117|Homo sapiens ADAMTS6 variant 2 protein. 115 4e-25
DQ422807-1|ABD72606.1| 1427|Homo sapiens ADAM metallopeptidase w... 114 8e-25
AY055376-1|AAL17652.1| 1427|Homo sapiens von Willebrand factor-c... 114 8e-25
AL593848-11|CAI17258.1| 1371|Homo sapiens ADAM metallopeptidase ... 114 8e-25
AL593848-10|CAI17256.1| 1427|Homo sapiens ADAM metallopeptidase ... 114 8e-25
AL158826-24|CAI12850.1| 1427|Homo sapiens ADAM metallopeptidase ... 114 8e-25
AL158826-22|CAI12851.1| 1371|Homo sapiens ADAM metallopeptidase ... 114 8e-25
AJ420810-1|CAD12729.1| 1371|Homo sapiens ADAMTS-13 protein, vari... 114 8e-25
AF414401-1|AAL11095.1| 1427|Homo sapiens ADAMTS13 protein. 114 8e-25
AB069698-1|BAB69487.2| 1427|Homo sapiens von Willebrand factor-c... 114 8e-25
AB209497-1|BAD92734.1| 527|Homo sapiens a disintegrin and metal... 113 2e-24
DQ266047-1|ABB70405.1| 570|Homo sapiens ADAMTS16s alternative s... 112 4e-24
BC132735-1|AAI32736.1| 1205|Homo sapiens ADAMTS3 protein protein. 109 3e-23
BC130287-1|AAI30288.1| 1205|Homo sapiens ADAM metallopeptidase w... 109 3e-23
AB002364-1|BAA20821.1| 1201|Homo sapiens KIAA0366 protein. 109 3e-23
BC109114-1|AAI09115.1| 950|Homo sapiens ADAM metallopeptidase w... 108 5e-23
AJ315733-1|CAC86014.1| 950|Homo sapiens metalloprotease disinte... 108 5e-23
AJ311904-1|CAC84565.1| 1207|Homo sapiens ADAMTS-19 protein. 108 7e-23
AY044847-1|AAL02262.1| 837|Homo sapiens aggrecanase 1 protein. 107 9e-23
AL590714-6|CAH72146.1| 837|Homo sapiens ADAM metallopeptidase w... 107 9e-23
AF148213-1|AAD41494.1| 837|Homo sapiens aggrecanase-1 protein. 107 9e-23
AB014588-1|BAA31663.2| 849|Homo sapiens KIAA0688 protein protein. 107 9e-23
AF488804-1|AAO15766.1| 1911|Homo sapiens a disintegrin-like and ... 106 2e-22
AY358886-1|AAQ89245.1| 837|Homo sapiens ADAMTS4 protein. 105 6e-22
BC063293-1|AAH63293.1| 837|Homo sapiens ADAM metallopeptidase w... 104 1e-21
AJ515154-1|CAD56160.2| 1502|Homo sapiens ADAMTS-20 protein protein. 103 1e-21
AJ515153-1|CAD56159.3| 1908|Homo sapiens ADAMTS-20 protein protein. 103 1e-21
AY692425-1|AAW47398.1| 468|Homo sapiens ADAMTS6 variant 3 protein. 101 6e-21
AF163762-1|AAG35563.1| 1077|Homo sapiens zinc metalloendopeptida... 101 6e-21
BC113874-1|AAI13875.1| 676|Homo sapiens ADAMTS8 protein protein. 101 8e-21
AF060153-1|AAD48081.1| 890|Homo sapiens METH2 protein protein. 100 3e-20
BC089435-1|AAH89435.1| 918|Homo sapiens ADAMTS8 protein protein. 99 4e-20
BC036515-1|AAH36515.1| 967|Homo sapiens ADAM metallopeptidase w... 97 1e-19
AP001697-1|BAA95502.1| 967|Homo sapiens metalloprotease with th... 97 1e-19
AF207664-1|AAF23772.1| 967|Homo sapiens matrix metalloprotease ... 97 1e-19
AF060152-1|AAD48080.1| 950|Homo sapiens METH1 protein protein. 97 1e-19
AB037767-1|BAA92584.1| 999|Homo sapiens KIAA1346 protein protein. 97 1e-19
AF170084-1|AAF15317.1| 967|Homo sapiens metalloproteinase with ... 97 2e-19
AB209515-1|BAD92752.1| 847|Homo sapiens a disintegrin-like and ... 96 4e-19
BC093777-1|AAH93777.1| 930|Homo sapiens ADAM metallopeptidase w... 95 7e-19
BC093775-1|AAH93775.1| 930|Homo sapiens ADAM metallopeptidase w... 95 7e-19
AF142099-1|AAD49577.1| 930|Homo sapiens aggrecanase-2 protein. 95 7e-19
AF140674-1|AAD56357.1| 860|Homo sapiens zinc metalloprotease AD... 94 1e-18
AL593848-9|CAI17257.1| 1340|Homo sapiens ADAM metallopeptidase w... 91 1e-17
AL158826-23|CAI12852.1| 1340|Homo sapiens ADAM metallopeptidase ... 91 1e-17
AJ420811-1|CAD12730.1| 344|Homo sapiens ADAMTS-13 protein, trun... 91 1e-17
AJ305314-1|CAC83682.1| 1340|Homo sapiens ADAMTS-13 protein protein. 91 1e-17
AF175283-1|AAF25806.1| 246|Homo sapiens zinc metalloendopeptida... 83 2e-15
BC130578-1|AAI30579.1| 1935|Homo sapiens ADAM metallopeptidase w... 83 4e-15
AF488803-1|AAO15765.1| 1935|Homo sapiens a disintegrin-like and ... 83 4e-15
AB037733-1|BAA92550.1| 1471|Homo sapiens KIAA1312 protein protein. 83 4e-15
AF261918-1|AAF89106.1| 1072|Homo sapiens disintegrin metalloprot... 80 2e-14
AP001698-1|BAA95504.1| 412|Homo sapiens disintegrin-like and me... 67 2e-10
BC103829-1|AAI03830.1| 276|Homo sapiens ADAMTS13 protein protein. 65 6e-10
BC103828-1|AAI03829.1| 276|Homo sapiens ADAMTS13 protein protein. 65 6e-10
U41766-1|AAC50403.1| 819|Homo sapiens metalloprotease/disintegr... 58 9e-08
D14665-1|BAA03499.2| 703|Homo sapiens KIAA0021 protein protein. 58 9e-08
BC126406-1|AAI26407.1| 712|Homo sapiens ADAM9 protein protein. 58 9e-08
AF495383-1|AAM49575.1| 655|Homo sapiens disintegrin/metalloprot... 58 9e-08
BC030812-1|AAH30812.1| 339|Homo sapiens ADAMTS4 protein protein. 58 1e-07
AL590714-7|CAH72147.1| 339|Homo sapiens ADAM metallopeptidase w... 58 1e-07
AY532929-1|AAS54901.1| 90|Homo sapiens von Willebrand factor-c... 49 4e-05
D26579-1|BAA05626.1| 824|Homo sapiens transmembrane protein pro... 48 1e-04
AK129873-1|BAC85245.1| 226|Homo sapiens protein ( Homo sapiens ... 47 2e-04
BC115404-1|AAI15405.1| 824|Homo sapiens ADAM8 protein protein. 46 4e-04
AF215824-1|AAG43987.1| 754|Homo sapiens a disintegrin and metal... 46 4e-04
BC043207-1|AAH43207.2| 559|Homo sapiens ADAM7 protein protein. 44 0.001
U46005-1|AAC51112.1| 814|Homo sapiens MDC15 protein. 44 0.002
U41767-1|AAC50404.1| 814|Homo sapiens metargidin precursor prot... 44 0.002
BT009764-1|AAP88766.1| 814|Homo sapiens a disintegrin and metal... 44 0.002
BC014566-1|AAH14566.1| 814|Homo sapiens ADAM metallopeptidase d... 44 0.002
AY576417-1|AAS73000.1| 797|Homo sapiens ADAM15 isoform 8 protein. 44 0.002
AY560601-1|AAS72999.1| 822|Homo sapiens ADAM15 isoform 7b protein. 44 0.002
AY560600-1|AAS72998.1| 821|Homo sapiens ADAM15 isoform 7a protein. 44 0.002
AY560599-1|AAS72997.1| 863|Homo sapiens ADAM15 isoform 6b protein. 44 0.002
AY560598-1|AAS72996.1| 862|Homo sapiens ADAM15 isoform 6a protein. 44 0.002
AY560597-1|AAS72995.1| 838|Homo sapiens ADAM15 isoform 5 protein. 44 0.002
AY560596-1|AAS72994.1| 839|Homo sapiens ADAM15 isoform 4a protein. 44 0.002
AY560595-1|AAS72993.1| 796|Homo sapiens ADAM15 isoform 3a protein. 44 0.002
AY560594-1|AAS72992.1| 814|Homo sapiens ADAM15 isoform 2 protein. 44 0.002
AY560593-1|AAS72991.1| 772|Homo sapiens ADAM15 isoform 1 protein. 44 0.002
AY518542-1|AAR99331.1| 772|Homo sapiens ADAM-15 precursor protein. 44 0.002
AL691442-13|CAI15327.1| 814|Homo sapiens ADAM metallopeptidase ... 44 0.002
AL451085-35|CAI13274.1| 814|Homo sapiens ADAM metallopeptidase ... 44 0.002
AF314227-11|AAS72298.1| 797|Homo sapiens ADAM15 isoform 8 protein. 44 0.002
AF314227-10|AAS48596.1| 821|Homo sapiens ADAM15 isoform 7a prot... 44 0.002
AF314227-9|AAS48597.1| 822|Homo sapiens ADAM15 isoform 7b protein. 44 0.002
AF314227-8|AAS48590.1| 772|Homo sapiens ADAM15 isoform 1 protein. 44 0.002
AF314227-7|AAS48591.1| 796|Homo sapiens ADAM15 isoform 3a protein. 44 0.002
AF314227-6|AAM44189.1| 814|Homo sapiens ADAM15 isoform 2 protein. 44 0.002
AF314227-5|AAS48593.1| 838|Homo sapiens ADAM15 isoform 5 protein. 44 0.002
AF314227-4|AAS48594.1| 862|Homo sapiens ADAM15 isoform 6a protein. 44 0.002
AF314227-3|AAS48592.1| 839|Homo sapiens ADAM15 isoform 4a protein. 44 0.002
AF314227-2|AAS48595.1| 863|Homo sapiens ADAM15 isoform 6b protein. 44 0.002
AB209157-1|BAD92394.1| 859|Homo sapiens ADAM15 isoform 6a varia... 44 0.002
DQ995342-1|ABI97387.1| 813|Homo sapiens ADAM metallopeptidase d... 43 0.003
AY358314-1|AAQ88680.1| 813|Homo sapiens Adam33 protein. 43 0.003
AL356755-2|CAI23465.1| 813|Homo sapiens ADAM metallopeptidase d... 43 0.003
AL356755-1|CAM28348.1| 812|Homo sapiens ADAM metallopeptidase d... 43 0.003
AL109804-2|CAI18840.1| 813|Homo sapiens ADAM metallopeptidase d... 43 0.003
AL109804-1|CAM26955.1| 812|Homo sapiens ADAM metallopeptidase d... 43 0.003
AF466288-1|AAM80483.1| 812|Homo sapiens a disintegrin and metal... 43 0.003
AF466287-1|AAM80482.1| 812|Homo sapiens a disintegrin and metal... 43 0.003
AB055891-1|BAB83092.1| 813|Homo sapiens metalloprotease disinte... 43 0.003
AF090327-1|AAC36742.1| 588|Homo sapiens sperm maturation-relate... 43 0.004
BC109025-1|AAI09026.1| 721|Homo sapiens ADAM21 protein protein. 42 0.005
BC109024-1|AAI09025.1| 722|Homo sapiens ADAM metallopeptidase d... 42 0.005
AF158644-1|AAD55255.1| 722|Homo sapiens metalloproteinase-disin... 42 0.005
BC060804-1|AAH60804.1| 737|Homo sapiens ADAM metallopeptidase d... 42 0.007
AY358878-1|AAQ89237.1| 735|Homo sapiens ADAM-12 protein. 42 0.007
AL589787-6|CAI40683.1| 738|Homo sapiens ADAM metallopeptidase d... 42 0.007
AL589787-5|CAI40682.1| 909|Homo sapiens ADAM metallopeptidase d... 42 0.007
AF023477-1|AAC08703.2| 738|Homo sapiens meltrin-S protein. 42 0.007
AF023476-1|AAC08702.2| 909|Homo sapiens meltrin-L precursor pro... 42 0.007
BC125118-1|AAI25119.1| 870|Homo sapiens ADAM metallopeptidase d... 42 0.009
BC092465-1|AAH92465.1| 342|Homo sapiens ADAM22 protein protein. 42 0.009
BC062433-1|AAH62433.1| 242|Homo sapiens ADAM22 protein protein. 42 0.009
BC036029-1|AAH36029.1| 342|Homo sapiens ADAM22 protein protein. 42 0.009
AF158637-1|AAD55251.1| 867|Homo sapiens metalloproteinase-disin... 42 0.009
AF155382-1|AAF73289.1| 906|Homo sapiens metalloprotease-like, d... 42 0.009
AF155381-1|AAF73288.1| 899|Homo sapiens metalloprotease-like, d... 42 0.009
AF073291-1|AAF22476.2| 870|Homo sapiens MDC2 protein. 42 0.009
AB009671-2|BAA32350.1| 823|Homo sapiens MDC2 beta protein. 42 0.009
AB009671-1|BAA32349.1| 859|Homo sapiens MDC2 alpha protein. 42 0.009
DQ202398-1|ABA43715.1| 465|Homo sapiens ADAM21-like protein pro... 40 0.026
AL162080-1|CAB82413.1| 550|Homo sapiens hypothetical protein pr... 40 0.026
AJ242015-1|CAB42085.1| 775|Homo sapiens eMDC II protein protein. 39 0.046
AF137335-1|AAD25100.1| 540|Homo sapiens metalloprotease disinte... 39 0.046
AF137334-1|AAD25099.1| 775|Homo sapiens metalloprotease disinte... 39 0.046
AF171931-1|AAF03779.1| 787|Homo sapiens metallaproteinase-disin... 39 0.061
AF171930-1|AAF03778.1| 766|Homo sapiens metallaproteinase-disin... 39 0.061
AF171929-1|AAF03777.1| 820|Homo sapiens metallaproteinase-disin... 39 0.061
AF134708-1|AAF22163.1| 820|Homo sapiens disintegrin and metallo... 39 0.061
AC105914-1|AAY41055.1| 820|Homo sapiens unknown protein. 39 0.061
Y13786-1|CAC20585.1| 918|Homo sapiens meltrin-beta/ADAM 19 homo... 38 0.11
AF311317-1|AAK07852.1| 918|Homo sapiens disintegrin and metallo... 38 0.11
AF134707-1|AAF22162.1| 857|Homo sapiens disintegrin and metallo... 38 0.11
AF029900-1|AAC52042.1| 542|Homo sapiens ADAM 21 protein. 38 0.11
AK128469-1|BAC87455.1| 327|Homo sapiens protein ( Homo sapiens ... 37 0.19
AY692426-1|AAW47399.1| 292|Homo sapiens ADAMTS6 variant 4 protein. 37 0.24
Y13323-1|CAA73764.2| 470|Homo sapiens disintegrin-protease prot... 36 0.43
BC074878-1|AAH74878.1| 470|Homo sapiens ADAM-like, decysin 1 pr... 36 0.43
BC074877-1|AAH74877.1| 470|Homo sapiens ADAM-like, decysin 1 pr... 36 0.43
BC069582-1|AAH69582.1| 470|Homo sapiens ADAM-like, decysin 1 pr... 36 0.43
AF141293-1|AAF02493.1| 518|Homo sapiens ADAMTS5 protein protein. 35 0.75
BC025378-1|AAH25378.2| 776|Homo sapiens ADAM metallopeptidase d... 35 0.99
AF247668-1|AAK28400.1| 227|Homo sapiens a disintegrin-like and ... 35 0.99
AF158643-1|AAD55254.1| 726|Homo sapiens metalloproteinase-disin... 35 0.99
AF029899-1|AAC52041.1| 726|Homo sapiens ADAM 20 protein. 35 0.99
AK096298-1|BAC04753.1| 262|Homo sapiens protein ( Homo sapiens ... 33 4.0
BC109092-1|AAI09093.1| 664|Homo sapiens peptidyl arginine deimi... 32 5.3
BC109091-1|AAI09092.1| 664|Homo sapiens peptidyl arginine deimi... 32 5.3
BC041592-1|AAH41592.1| 664|Homo sapiens peptidyl arginine deimi... 32 5.3
AL590644-2|CAH73166.1| 664|Homo sapiens peptidyl arginine deimi... 32 5.3
AJ549502-4|CAE47742.1| 664|Homo sapiens peptidylarginine deimin... 32 5.3
AB026831-1|BAA85974.1| 664|Homo sapiens peptidylarginine deimin... 32 5.3
AP001697-2|BAA95503.1| 517|Homo sapiens disintegrin-like and me... 32 7.0
>AL358817-5|CAI13857.1| 1226|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 14 protein.
Length = 1226
Score = 140 bits (338), Expect = 2e-32
Identities = 149/521 (28%), Positives = 205/521 (39%), Gaps = 78/521 (14%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRV-WTERGEEKPLSSVDASCHF---LHASPNAV 111
L +N FG+ L+L PNRRLV P V W E E + C + + P A
Sbjct: 106 LYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA 165
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRR-------ASPPSX 164
A S C L GLI D++ + + PL G E S GRT V RR A P
Sbjct: 166 VAISNCD--GLAGLIRTDSTDFFIEPLERGQQEKEAS-GRTHVVYRREAVQQEWAEPDGD 222
Query: 165 XXXXXXXXXXX-------XXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYN 217
P SY+IE+ L +D++ + FH
Sbjct: 223 LHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVR-----FHGK 277
Query: 218 EADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLR-SQPTDLSAHAERGKLLDSFC 276
E +++ +L +N V +Y SLG HI ++LVRL ++ Q L + L+ C
Sbjct: 278 E-HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVC 336
Query: 277 AYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSE 336
+ S +D EH D + L+ DF +G+ G APV G+C P +C ++
Sbjct: 337 RWAHSQQRQDPSHAEHHDHVVFLTRQDFGP------SGM-QGYAPVTGMCHPLRSCALNH 389
Query: 337 FGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARD---GYIMSP-SRGTNG 392
GF+S +++AHE GH LGM HDG GN CA + G +M+P +
Sbjct: 390 ------------EDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 437
Query: 393 EASWSSCSARVVAD-LKWATCLLDGD-DGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
WS CS ++ L CLLD D P EL PG +S +QC
Sbjct: 438 RFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPEL--------PGINYSMDEQCRFDF 489
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGECXXXX 508
+ + C QL C P F GP L GT C WC G C
Sbjct: 490 GSGYQTCLAFRTFE--PCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---- 543
Query: 509 XXXXXXXXXXXXAGMAEGESGGWTVWRE-GACRSGCSAKSR 548
G+ GGW+ W + G+C C R
Sbjct: 544 --------IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVR 576
>AL355344-5|CAI41278.1| 1226|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 14 protein.
Length = 1226
Score = 140 bits (338), Expect = 2e-32
Identities = 149/521 (28%), Positives = 205/521 (39%), Gaps = 78/521 (14%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRV-WTERGEEKPLSSVDASCHF---LHASPNAV 111
L +N FG+ L+L PNRRLV P V W E E + C + + P A
Sbjct: 106 LYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA 165
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRR-------ASPPSX 164
A S C L GLI D++ + + PL G E S GRT V RR A P
Sbjct: 166 VAISNCD--GLAGLIRTDSTDFFIEPLERGQQEKEAS-GRTHVVYRREAVQQEWAEPDGD 222
Query: 165 XXXXXXXXXXX-------XXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYN 217
P SY+IE+ L +D++ + FH
Sbjct: 223 LHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVR-----FHGK 277
Query: 218 EADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLR-SQPTDLSAHAERGKLLDSFC 276
E +++ +L +N V +Y SLG HI ++LVRL ++ Q L + L+ C
Sbjct: 278 E-HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVC 336
Query: 277 AYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSE 336
+ S +D EH D + L+ DF +G+ G APV G+C P +C ++
Sbjct: 337 RWAHSQQRQDPSHAEHHDHVVFLTRQDFGP------SGM-QGYAPVTGMCHPLRSCALNH 389
Query: 337 FGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARD---GYIMSP-SRGTNG 392
GF+S +++AHE GH LGM HDG GN CA + G +M+P +
Sbjct: 390 ------------EDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 437
Query: 393 EASWSSCSARVVAD-LKWATCLLDGD-DGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
WS CS ++ L CLLD D P EL PG +S +QC
Sbjct: 438 RFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPEL--------PGINYSMDEQCRFDF 489
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGECXXXX 508
+ + C QL C P F GP L GT C WC G C
Sbjct: 490 GSGYQTCLAFRTFE--PCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---- 543
Query: 509 XXXXXXXXXXXXAGMAEGESGGWTVWRE-GACRSGCSAKSR 548
G+ GGW+ W + G+C C R
Sbjct: 544 --------IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVR 576
>AF366351-1|AAL79814.1| 1159|Homo sapiens ADAMTS14 protein.
Length = 1159
Score = 140 bits (338), Expect = 2e-32
Identities = 149/521 (28%), Positives = 205/521 (39%), Gaps = 78/521 (14%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRV-WTERGEEKPLSSVDASCHF---LHASPNAV 111
L +N FG+ L+L PNRRLV P V W E E + C + + P A
Sbjct: 39 LYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA 98
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRR-------ASPPSX 164
A S C L GLI D++ + + PL G E S GRT V RR A P
Sbjct: 99 VAISNCD--GLAGLIRTDSTDFFIEPLERGQQEKEAS-GRTHVVYRREAVQQEWAEPDGD 155
Query: 165 XXXXXXXXXXX-------XXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYN 217
P SY+IE+ L +D++ + FH
Sbjct: 156 LHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVR-----FHGK 210
Query: 218 EADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLR-SQPTDLSAHAERGKLLDSFC 276
E +++ +L +N V +Y SLG HI ++LVRL ++ Q L + L+ C
Sbjct: 211 E-HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVC 269
Query: 277 AYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSE 336
+ S +D EH D + L+ DF +G+ G APV G+C P +C ++
Sbjct: 270 RWAHSQQRQDPSHAEHHDHVVFLTRQDFGP------SGM-QGYAPVTGMCHPLRSCALNH 322
Query: 337 FGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARD---GYIMSP-SRGTNG 392
GF+S +++AHE GH LGM HDG GN CA + G +M+P +
Sbjct: 323 ------------EDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 370
Query: 393 EASWSSCSARVVAD-LKWATCLLDGD-DGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
WS CS ++ L CLLD D P EL PG +S +QC
Sbjct: 371 RFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPEL--------PGINYSMDEQCRFDF 422
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGECXXXX 508
+ + C QL C P F GP L GT C WC G C
Sbjct: 423 GSGYQTCLAFRTFE--PCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---- 476
Query: 509 XXXXXXXXXXXXAGMAEGESGGWTVWRE-GACRSGCSAKSR 548
G+ GGW+ W + G+C C R
Sbjct: 477 --------IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVR 509
>AL358817-4|CAI13858.1| 1223|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 14 protein.
Length = 1223
Score = 138 bits (333), Expect = 7e-32
Identities = 148/521 (28%), Positives = 202/521 (38%), Gaps = 81/521 (15%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRV-WTERGEEKPLSSVDASCHF---LHASPNAV 111
L +N FG+ L+L PNRRLV P V W E E + C + + P A
Sbjct: 106 LYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA 165
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRR-------ASPPSX 164
A S C L GLI D++ + + PL G E S GRT V RR A P
Sbjct: 166 VAISNCD--GLAGLIRTDSTDFFIEPLERGQQEKEAS-GRTHVVYRREAVQQEWAEPDGD 222
Query: 165 XXXXXXXXXXX-------XXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYN 217
P SY+IE+ L +D++ + FH
Sbjct: 223 LHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVR-----FHGK 277
Query: 218 EADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLR-SQPTDLSAHAERGKLLDSFC 276
E +++ +L +N V +Y SLG HI ++LVRL ++ Q L + L+ C
Sbjct: 278 E-HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVC 336
Query: 277 AYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSE 336
+ S +D EH D + L+ DF G APV G+C P +C ++
Sbjct: 337 RWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS----------GYAPVTGMCHPLRSCALNH 386
Query: 337 FGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARD---GYIMSP-SRGTNG 392
GF+S +++AHE GH LGM HDG GN CA + G +M+P +
Sbjct: 387 ------------EDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 434
Query: 393 EASWSSCSARVVAD-LKWATCLLDGD-DGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
WS CS ++ L CLLD D P EL PG +S +QC
Sbjct: 435 RFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPEL--------PGINYSMDEQCRFDF 486
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGECXXXX 508
+ + C QL C P F GP L GT C WC G C
Sbjct: 487 GSGYQTCLAFRTFE--PCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---- 540
Query: 509 XXXXXXXXXXXXAGMAEGESGGWTVWRE-GACRSGCSAKSR 548
G+ GGW+ W + G+C C R
Sbjct: 541 --------IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVR 573
>AL355344-4|CAI41277.1| 1223|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 14 protein.
Length = 1223
Score = 138 bits (333), Expect = 7e-32
Identities = 148/521 (28%), Positives = 202/521 (38%), Gaps = 81/521 (15%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRV-WTERGEEKPLSSVDASCHF---LHASPNAV 111
L +N FG+ L+L PNRRLV P V W E E + C + + P A
Sbjct: 106 LYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA 165
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRR-------ASPPSX 164
A S C L GLI D++ + + PL G E S GRT V RR A P
Sbjct: 166 VAISNCD--GLAGLIRTDSTDFFIEPLERGQQEKEAS-GRTHVVYRREAVQQEWAEPDGD 222
Query: 165 XXXXXXXXXXX-------XXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYN 217
P SY+IE+ L +D++ + FH
Sbjct: 223 LHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVR-----FHGK 277
Query: 218 EADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLR-SQPTDLSAHAERGKLLDSFC 276
E +++ +L +N V +Y SLG HI ++LVRL ++ Q L + L+ C
Sbjct: 278 E-HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVC 336
Query: 277 AYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSE 336
+ S +D EH D + L+ DF G APV G+C P +C ++
Sbjct: 337 RWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS----------GYAPVTGMCHPLRSCALNH 386
Query: 337 FGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARD---GYIMSP-SRGTNG 392
GF+S +++AHE GH LGM HDG GN CA + G +M+P +
Sbjct: 387 ------------EDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 434
Query: 393 EASWSSCSARVVAD-LKWATCLLDGD-DGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
WS CS ++ L CLLD D P EL PG +S +QC
Sbjct: 435 RFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPEL--------PGINYSMDEQCRFDF 486
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGECXXXX 508
+ + C QL C P F GP L GT C WC G C
Sbjct: 487 GSGYQTCLAFRTFE--PCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---- 540
Query: 509 XXXXXXXXXXXXAGMAEGESGGWTVWRE-GACRSGCSAKSR 548
G+ GGW+ W + G+C C R
Sbjct: 541 --------IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVR 573
>AJ345098-1|CAC87943.1| 1223|Homo sapiens
metalloprotease-disintegrin protease protein.
Length = 1223
Score = 138 bits (333), Expect = 7e-32
Identities = 148/521 (28%), Positives = 202/521 (38%), Gaps = 81/521 (15%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRV-WTERGEEKPLSSVDASCHF---LHASPNAV 111
L +N FG+ L+L PNRRLV P V W E E + C + + P A
Sbjct: 106 LYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA 165
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRR-------ASPPSX 164
A S C L GLI D++ + + PL G E S GRT V RR A P
Sbjct: 166 VAISNCD--GLAGLIRTDSTDFFIEPLERGQQEKEAS-GRTHVVYRREAVQQEWAEPDGD 222
Query: 165 XXXXXXXXXXX-------XXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYN 217
P SY+IE+ L +D++ + FH
Sbjct: 223 LHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVR-----FHGK 277
Query: 218 EADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLR-SQPTDLSAHAERGKLLDSFC 276
E +++ +L +N V +Y SLG HI ++LVRL ++ Q L + L+ C
Sbjct: 278 E-HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVC 336
Query: 277 AYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSE 336
+ S +D EH D + L+ DF G APV G+C P +C ++
Sbjct: 337 RWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS----------GYAPVTGMCHPLRSCALNH 386
Query: 337 FGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARD---GYIMSP-SRGTNG 392
GF+S +++AHE GH LGM HDG GN CA + G +M+P +
Sbjct: 387 ------------EDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 434
Query: 393 EASWSSCSARVVAD-LKWATCLLDGD-DGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
WS CS ++ L CLLD D P EL PG +S +QC
Sbjct: 435 RFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPEL--------PGINYSMDEQCRFDF 486
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGECXXXX 508
+ + C QL C P F GP L GT C WC G C
Sbjct: 487 GSGYQTCLAFRTFE--PCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---- 540
Query: 509 XXXXXXXXXXXXAGMAEGESGGWTVWRE-GACRSGCSAKSR 548
G+ GGW+ W + G+C C R
Sbjct: 541 --------IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVR 573
>AF358666-1|AAL40229.1| 1223|Homo sapiens a disintegrin-like and
metalloprotease with thrombospondin type 1 motif 14 prec
protein.
Length = 1223
Score = 138 bits (333), Expect = 7e-32
Identities = 148/521 (28%), Positives = 202/521 (38%), Gaps = 81/521 (15%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRV-WTERGEEKPLSSVDASCHF---LHASPNAV 111
L +N FG+ L+L PNRRLV P V W E E + C + + P A
Sbjct: 106 LYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA 165
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRR-------ASPPSX 164
A S C L GLI D++ + + PL G E S GRT V RR A P
Sbjct: 166 VAISNCD--GLAGLIRTDSTDFFIEPLERGQQEKEAS-GRTHVVYRREAVQQEWAEPDGD 222
Query: 165 XXXXXXXXXXX-------XXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYN 217
P SY+IE+ L +D++ + FH
Sbjct: 223 LHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVR-----FHGK 277
Query: 218 EADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLR-SQPTDLSAHAERGKLLDSFC 276
E +++ +L +N V +Y SLG HI ++LVRL ++ Q L + L+ C
Sbjct: 278 E-HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVC 336
Query: 277 AYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSE 336
+ S +D EH D + L+ DF G APV G+C P +C ++
Sbjct: 337 RWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS----------GYAPVTGMCHPLRSCALNH 386
Query: 337 FGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARD---GYIMSP-SRGTNG 392
GF+S +++AHE GH LGM HDG GN CA + G +M+P +
Sbjct: 387 ------------EDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 434
Query: 393 EASWSSCSARVVAD-LKWATCLLDGD-DGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
WS CS ++ L CLLD D P EL PG +S +QC
Sbjct: 435 RFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPEL--------PGINYSMDEQCRFDF 486
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGECXXXX 508
+ + C QL C P F GP L GT C WC G C
Sbjct: 487 GSGYQTCLAFRTFE--PCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---- 540
Query: 509 XXXXXXXXXXXXAGMAEGESGGWTVWRE-GACRSGCSAKSR 548
G+ GGW+ W + G+C C R
Sbjct: 541 --------IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVR 573
>BC063283-1|AAH63283.1| 1221|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 18 protein.
Length = 1221
Score = 133 bits (321), Expect = 2e-30
Identities = 95/297 (31%), Positives = 146/297 (49%), Gaps = 36/297 (12%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
+ + ++ +L +N V L++ ++G+ I + +V L LL +P L + + L+SF
Sbjct: 309 HGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSF 368
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q +L ++ + +H A+LL+G D S +N + T+G AP+ G+C +C ++
Sbjct: 369 CQWQSALIGKNGKRHDH---AILLTGFDICSWKNEPCD--TLGFAPISGMCSKYRSCTIN 423
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCAR-DGYIMSPS-RGTNGE 393
E G + +AHE GHN GM HDG GN C + +G IMSP+ G NG
Sbjct: 424 E------------DTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGV 471
Query: 394 ASWSSCSARVV---ADLKWATCLLD--GDDGEEDIPNELQHERFSGAPGAIWSAKKQCEV 448
SWSSCS + + A CL+D G+ P++L PG I+ A QC+
Sbjct: 472 FSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKL--------PGQIYDADTQCK- 522
Query: 449 LLRDADAAPWSGGGDQRGQCAQLAC-RTPHRAGFFYAGPALPGTACGNKMWCQGGEC 504
+ A G + C L C R HR + PA GT CG MWC+ G+C
Sbjct: 523 -WQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFM-PAAEGTVCGLSMWCRQGQC 577
Score = 31.5 bits (68), Expect = 9.2
Identities = 27/104 (25%), Positives = 43/104 (41%), Gaps = 8/104 (7%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEF--RVWTERGEEKPLSSVDASCH---FLHASPNA 110
L Y F AFG+ L+L P+ ++S F +V + G + C F+ ++
Sbjct: 97 LHYRFSAFGQELHLELKPS-AILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSS 155
Query: 111 VAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAH 154
A S C L GLI + + + PLP + + N H
Sbjct: 156 SVAVSTCA--GLSGLIRTRKNEFLISPLPQLLAQEHNHSSPAGH 197
>AJ315734-1|CAC86015.1| 1072|Homo sapiens metalloprotease
disintegrin 16 with thrombospondin type I motif protein.
Length = 1072
Score = 130 bits (313), Expect = 2e-29
Identities = 91/296 (30%), Positives = 140/296 (47%), Gaps = 32/296 (10%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ ++ +L +N V AL++ ++G +I +++V L LL + L L S
Sbjct: 305 NHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSS 364
Query: 275 FCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVV 334
FC +Q L +D +H A+LL+GLD S +N + T+G AP+ G+C +C +
Sbjct: 365 FCQWQSGLMGKDGTRHDH---AILLTGLDICSWKNEPCD--TLGFAPISGMCSKYRSCTI 419
Query: 335 SEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCAR-DGYIMSPS-RGTNG 392
+E G + +AHE GHN GM HDG GN C + +G IMSP+ G NG
Sbjct: 420 NE------------DTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNG 467
Query: 393 EASWSSCSARVV---ADLKWATCLLDGDDGEEDIPNELQHERF-SGAPGAIWSAKKQCEV 448
SWS CS + + A CL D P ++ ++ PG ++ A QC+
Sbjct: 468 VFSWSPCSRQYLHKFLSTAQAICLADQ-------PKPVKEYKYPEKLPGELYDANTQCK- 519
Query: 449 LLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTACGNKMWCQGGEC 504
+ + A ++ C L C R PA GT CG+ MWC+GG+C
Sbjct: 520 -WQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQC 574
>AB095949-1|BAC23125.1| 1021|Homo sapiens KIAA2029 protein protein.
Length = 1021
Score = 130 bits (313), Expect = 2e-29
Identities = 91/296 (30%), Positives = 140/296 (47%), Gaps = 32/296 (10%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ ++ +L +N V AL++ ++G +I +++V L LL + L L S
Sbjct: 102 NHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSS 161
Query: 275 FCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVV 334
FC +Q L +D +H A+LL+GLD S +N + T+G AP+ G+C +C +
Sbjct: 162 FCQWQSGLMGKDGTRHDH---AILLTGLDICSWKNEPCD--TLGFAPISGMCSKYRSCTI 216
Query: 335 SEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCAR-DGYIMSPS-RGTNG 392
+E G + +AHE GHN GM HDG GN C + +G IMSP+ G NG
Sbjct: 217 NE------------DTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNG 264
Query: 393 EASWSSCSARVV---ADLKWATCLLDGDDGEEDIPNELQHERF-SGAPGAIWSAKKQCEV 448
SWS CS + + A CL D P ++ ++ PG ++ A QC+
Sbjct: 265 VFSWSPCSRQYLHKFLSTAQAICLADQ-------PKPVKEYKYPEKLPGELYDANTQCK- 316
Query: 449 LLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTACGNKMWCQGGEC 504
+ + A ++ C L C R PA GT CG+ MWC+GG+C
Sbjct: 317 -WQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQC 371
>AJ311903-1|CAC83612.1| 1081|Homo sapiens ADAMTS18 protein protein.
Length = 1081
Score = 127 bits (307), Expect = 1e-28
Identities = 93/281 (33%), Positives = 137/281 (48%), Gaps = 36/281 (12%)
Query: 232 VQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPE 291
V L++ ++G+ I + +V L LL +P L + + L+SFC +Q +L ++ + +
Sbjct: 324 VSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHD 383
Query: 292 HWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAG 351
H A+LL+G D S +N + T+G AP G+C +C ++E G
Sbjct: 384 H---AILLTGFDICSWKNEPCD--TLGFAPTSGMCSKYRSCTINE------------DTG 426
Query: 352 FTSVYILAHEIGHNLGMHHDGTGNTCAR-DGYIMSPS-RGTNGEASWSSCSARVV---AD 406
+ +AHE GHN GM HDG GN C + +G IMSP+ G NG SWSSCS + +
Sbjct: 427 LGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLS 486
Query: 407 LKWATCLLD--GDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLRDADAAPWSGGGDQ 464
A CL+D G+ P++L PG I+ A QC+ + A G
Sbjct: 487 TPQAGCLVDEPKQAGQYKYPDKL--------PGQIYDADTQCK--WQFGAKAKLCSLGFV 536
Query: 465 RGQCAQLAC-RTPHRAGFFYAGPALPGTACGNKMWCQGGEC 504
+ C L C R HR + PA GT CG MWC+ G+C
Sbjct: 537 KDICKSLWCHRVGHRCETKFM-PAAEGTVCGLSMWCRQGQC 576
>BC061631-1|AAH61631.1| 1686|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 7 protein.
Length = 1686
Score = 126 bits (303), Expect = 3e-28
Identities = 90/297 (30%), Positives = 134/297 (45%), Gaps = 33/297 (11%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ + + +L +N V L+ S+G I +++VRL LL + DL L S
Sbjct: 257 YHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKIMHHADNTLKS 316
Query: 275 FCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVV 334
FC +Q+S+N++ D P H D A+LL+ D + N R T+GL+ V G+C P +C +
Sbjct: 317 FCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMN--RPCETLGLSHVAGMCQPHRSCSI 374
Query: 335 SEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG---YIMSPSRGTN 391
+E G + +AHE+GH+ G+ HDG+GN C G +IMSP +
Sbjct: 375 NE------------DTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYD 422
Query: 392 -GEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCE 447
+WS CS + + D W CL +D P + + S PG ++ QC
Sbjct: 423 AAPLTWSRCSRQYITRFLDRGWGLCL-------DDPPAKDIIDFPSVPPGVLYDVSHQCR 475
Query: 448 VLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTACGNKMWCQGGEC 504
L A +A D C L C A+ GT CG WC GEC
Sbjct: 476 -LQYGAYSAFCE---DMDNVCHTLWCSVGTTC-HSKLDAAVDGTRCGENKWCLSGEC 527
Score = 35.5 bits (78), Expect = 0.56
Identities = 36/133 (27%), Positives = 51/133 (38%), Gaps = 13/133 (9%)
Query: 38 LLPREAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSV 97
L PR + D P Y GR L N+ L++P F T R + +
Sbjct: 62 LWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHI 121
Query: 98 DA---SCHFLH--ASP---NAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSY 149
A +CH L P +AA SAC L G+ + N Y + PL S R ++
Sbjct: 122 RAHTPACHLLGEVQDPELEGGLAAISAC--DGLKGVFQLSNEDYFIEPLDSAPARPGHA- 178
Query: 150 GRTAHVIRRASPP 162
HV+ + P
Sbjct: 179 --QPHVVYKRQAP 189
>AY327122-1|AAQ94616.1| 1686|Homo sapiens COMPase precursor protein.
Length = 1686
Score = 126 bits (303), Expect = 3e-28
Identities = 90/297 (30%), Positives = 134/297 (45%), Gaps = 33/297 (11%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ + + +L +N V L+ S+G I +++VRL LL + DL L S
Sbjct: 257 YHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKS 316
Query: 275 FCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVV 334
FC +Q+S+N++ D P H D A+LL+ D + N R T+GL+ V G+C P +C +
Sbjct: 317 FCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMN--RPCETLGLSHVAGMCQPHRSCSI 374
Query: 335 SEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG---YIMSPSRGTN 391
+E G + +AHE+GH+ G+ HDG+GN C G +IMSP +
Sbjct: 375 NE------------DTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYD 422
Query: 392 -GEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCE 447
+WS CS + + D W CL +D P + + S PG ++ QC
Sbjct: 423 AAPLTWSRCSRQYITRFLDRGWGLCL-------DDPPAKDIIDFPSVPPGVLYDVSHQCR 475
Query: 448 VLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTACGNKMWCQGGEC 504
L A +A D C L C A+ GT CG WC GEC
Sbjct: 476 -LQYGAYSAFCE---DMDNVCHTLWCSVGTTC-HSKLDAAVDGTRCGENKWCLSGEC 527
Score = 35.5 bits (78), Expect = 0.56
Identities = 36/133 (27%), Positives = 51/133 (38%), Gaps = 13/133 (9%)
Query: 38 LLPREAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSV 97
L PR + D P Y GR L N+ L++P F T R + +
Sbjct: 62 LWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHI 121
Query: 98 DA---SCHFLH--ASP---NAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSY 149
A +CH L P +AA SAC L G+ + N Y + PL S R ++
Sbjct: 122 RAHTPACHLLGEVQDPELEGGLAAISAC--DGLKGVFQLSNEDYFIEPLDSAPARPGHA- 178
Query: 150 GRTAHVIRRASPP 162
HV+ + P
Sbjct: 179 --QPHVVYKRQAP 189
>AF140675-1|AAD56358.1| 997|Homo sapiens zinc metalloprotease
ADAMTS7 protein.
Length = 997
Score = 126 bits (303), Expect = 3e-28
Identities = 90/297 (30%), Positives = 134/297 (45%), Gaps = 33/297 (11%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ + + +L +N V L+ S+G I +++VRL LL + DL L S
Sbjct: 257 YHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKS 316
Query: 275 FCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVV 334
FC +Q+S+N++ D P H D A+LL+ D + N R T+GL+ V G+C P +C +
Sbjct: 317 FCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMN--RPCETLGLSHVAGMCQPHRSCSI 374
Query: 335 SEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG---YIMSPSRGTN 391
+E G + +AHE+GH+ G+ HDG+GN C G +IMSP +
Sbjct: 375 NE------------DTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYD 422
Query: 392 -GEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCE 447
+WS CS + + D W CL +D P + + S PG ++ QC
Sbjct: 423 AAPLTWSRCSRQYITRFLDRGWGLCL-------DDPPAKDIIDFPSVPPGVLYDVSHQCR 475
Query: 448 VLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTACGNKMWCQGGEC 504
L A +A D C L C A+ GT CG WC GEC
Sbjct: 476 -LQYGAYSAFCE---DMDNVCHTLWCSVGTTC-HSKLDAAVDGTRCGENKWCLSGEC 527
Score = 35.5 bits (78), Expect = 0.56
Identities = 36/133 (27%), Positives = 51/133 (38%), Gaps = 13/133 (9%)
Query: 38 LLPREAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSV 97
L PR + D P Y GR L N+ L++P F T R + +
Sbjct: 62 LWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHI 121
Query: 98 DA---SCHFLH--ASP---NAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSY 149
A +CH L P +AA SAC L G+ + N Y + PL S R ++
Sbjct: 122 RAHTPACHLLGEVQDPELEGGLAAISAC--DGLKGVFQLSNEDYFIEPLDSAPARPGHA- 178
Query: 150 GRTAHVIRRASPP 162
HV+ + P
Sbjct: 179 --QPHVVYKRQAP 189
>BC131733-1|AAI31734.1| 1509|Homo sapiens ADAMTS12 protein protein.
Length = 1509
Score = 122 bits (295), Expect = 3e-27
Identities = 90/299 (30%), Positives = 137/299 (45%), Gaps = 37/299 (12%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ ++ +L +N V L+ + S+G I + +VRL LL + L K L S
Sbjct: 261 YHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSS 320
Query: 275 FCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVV 334
FC +Q+S+N + D +P H D+A+LL+ D + N R T+GL+ + G+C P +C +
Sbjct: 321 FCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFN--RPCETLGLSHLSGMCQPHRSCNI 378
Query: 335 SEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC---ARDGYIMSPS-RGT 390
+E +G + +AHE+GH+ G+ HDG N C R YIMS +
Sbjct: 379 NE------------DSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYD 426
Query: 391 NGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCE 447
+WS CS + D W CL +DIP + + APG I+ QC+
Sbjct: 427 PTPLTWSKCSEEYITRFLDRGWGFCL-------DDIPKKKGLKSKVIAPGVIYDVHHQCQ 479
Query: 448 VLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGEC 504
L+ A + + C L C GF + A GT CG K WC G+C
Sbjct: 480 --LQYGPNATFC--QEVENVCQTLWCSV---KGFCRSKLDAAADGTQCGEKKWCMAGKC 531
>AJ250725-1|CAC20419.1| 1593|Homo sapiens a disintegrin-like and
metalloprotease (reprolysin type) with thrombospondin ty
protein.
Length = 1593
Score = 122 bits (295), Expect = 3e-27
Identities = 90/299 (30%), Positives = 137/299 (45%), Gaps = 37/299 (12%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ ++ +L +N V L+ + S+G I + +VRL LL + L K L S
Sbjct: 261 YHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSS 320
Query: 275 FCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVV 334
FC +Q+S+N + D +P H D+A+LL+ D + N R T+GL+ + G+C P +C +
Sbjct: 321 FCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFN--RPCETLGLSHLSGMCQPHRSCNI 378
Query: 335 SEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC---ARDGYIMSPS-RGT 390
+E +G + +AHE+GH+ G+ HDG N C R YIMS +
Sbjct: 379 NE------------DSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYD 426
Query: 391 NGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCE 447
+WS CS + D W CL +DIP + + APG I+ QC+
Sbjct: 427 PTPLTWSKCSEEYITRFLDRGWGFCL-------DDIPKKKGLKSKVIAPGVIYDVHHQCQ 479
Query: 448 VLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGEC 504
L+ A + + C L C GF + A GT CG K WC G+C
Sbjct: 480 --LQYGPNATFC--QEVENVCQTLWCSV---KGFCRSKLDAAADGTQCGEKKWCMAGKC 531
>AJ003125-1|CAA05880.1| 1211|Homo sapiens procollagen I N-proteinase
protein.
Length = 1211
Score = 121 bits (292), Expect = 7e-27
Identities = 140/491 (28%), Positives = 195/491 (39%), Gaps = 68/491 (13%)
Query: 46 SVDGSNDDVP---LPYNFDAFGRNFDLQLVPNRRLVSPEFRV-WT-ERGEEKPLSSVDAS 100
S G N++ P L YN FGR+ L+L PN RLV+P + W E+G + + + S
Sbjct: 96 SFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTR-VEPLLGS 154
Query: 101 CHFLHASPNAVAAFSACKDHA--LHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRR 158
C ++ A S + L GLI ++ + + PL G+ E GR V RR
Sbjct: 155 CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR 214
Query: 159 --ASPP--------------SXXXXXXXXXXXXXXXXXXXXXXXXKKGPASYTIEIALFL 202
SPP S Y IE+ L +
Sbjct: 215 PPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGV 274
Query: 203 DEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLR-SQPTD 261
D++ + FH E ++ LL +N V +Y SLG HI + LVR+ LL +
Sbjct: 275 DDSVVQ-----FHGKE-HVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMS 328
Query: 262 LSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAP 321
L + L++ C + D E+ D A+ L+ DF +G+ G AP
Sbjct: 329 LIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGP------SGM-QGYAP 381
Query: 322 VGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC---A 378
V G+C P +C ++ GF+S +++AHE GH LGM HDG GN C
Sbjct: 382 VTGMCHPVRSCTLNH------------EDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEV 429
Query: 379 RDGYIMSP-SRGTNGEASWSSCSARVVAD-LKWATCLLDGDDGEEDIPNELQHERFSGAP 436
R G IM+P + WS CS + ++ L CLLD D D P Q P
Sbjct: 430 RLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLD-DPFAHDWPALPQ------LP 482
Query: 437 GAIWSAKKQCEVLLRDADAAPWSGGGDQR-GQCAQLACRTPHRAGFFYA--GPALPGTAC 493
G +S +QC D + C QL C P F GP L GT C
Sbjct: 483 GLHYSMNEQCRF---DFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMC 539
Query: 494 GNKMWCQGGEC 504
C G C
Sbjct: 540 APGKHCFKGHC 550
>DQ217943-1|ABB70740.1| 1095|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif 17 protein.
Length = 1095
Score = 118 bits (284), Expect = 6e-26
Identities = 99/309 (32%), Positives = 144/309 (46%), Gaps = 41/309 (13%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
+H EA R +L +N V ++QH SLG I + + +L LLR +P LS + L+
Sbjct: 247 YHGAEAAQR-FILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLE 305
Query: 274 SFCAYQ-------RSLNVED----DEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPV 322
SFC +Q R L +DP D A+ ++ DF ++ + T+G+A +
Sbjct: 306 SFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCD--TVGIAYL 363
Query: 323 GGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGY 382
GGVC CV++E G + +AHE+GHNLGM+HD ++CA +
Sbjct: 364 GGVCSAKRKCVLAE------------DNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSH 411
Query: 383 IMSPS--RGTN-GEASWSSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAP 436
IMS +G N + SWSSCS + + K +TCLL D + L H+ P
Sbjct: 412 IMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTV-RLPHK----LP 466
Query: 437 GAIWSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGF-FYAGPALPGTACGN 495
G +SA +QC++L A + + CA L C P L GT CG
Sbjct: 467 GMHYSANEQCQILF--GMNATFCRNMEHL-MCAGLWCLVEGDTSCKTKLDPPLDGTECGA 523
Query: 496 KMWCQGGEC 504
WC+ GEC
Sbjct: 524 DKWCRAGEC 532
>AK131344-1|BAD18500.1| 502|Homo sapiens protein ( Homo sapiens
cDNA FLJ16363 fis, clone THYMU2031139, weakly similar
to Homo sapiens zinc metalloprotease ADAMTS7 (ADAMTS7)
mRNA. ).
Length = 502
Score = 118 bits (284), Expect = 6e-26
Identities = 99/309 (32%), Positives = 144/309 (46%), Gaps = 41/309 (13%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
+H EA R +L +N V ++QH SLG I + + +L LLR +P LS + L+
Sbjct: 4 YHGAEAAQR-FILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLE 62
Query: 274 SFCAYQ-------RSLNVED----DEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPV 322
SFC +Q R L +DP D A+ ++ DF ++ + T+G+A +
Sbjct: 63 SFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCD--TVGIAYL 120
Query: 323 GGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGY 382
GGVC CV++E G + +AHE+GHNLGM+HD ++CA +
Sbjct: 121 GGVCSAKRKCVLAE------------DNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSH 168
Query: 383 IMSPS--RGTN-GEASWSSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAP 436
IMS +G N + SWSSCS + + K +TCLL D + L H+ P
Sbjct: 169 IMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTV-RLPHK----LP 223
Query: 437 GAIWSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGF-FYAGPALPGTACGN 495
G +SA +QC++L A + + CA L C P L GT CG
Sbjct: 224 GMHYSANEQCQILF--GMNATFCRNMEHL-MCAGLWCLVEGDTSCKTKLDPPLDGTECGA 280
Query: 496 KMWCQGGEC 504
WC+ GEC
Sbjct: 281 DKWCRAGEC 289
>AJ315735-1|CAC86016.1| 1095|Homo sapiens metalloprotease
disintegrin 17, with thrombospondin domains protein.
Length = 1095
Score = 118 bits (284), Expect = 6e-26
Identities = 99/309 (32%), Positives = 144/309 (46%), Gaps = 41/309 (13%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
+H EA R +L +N V ++QH SLG I + + +L LLR +P LS + L+
Sbjct: 247 YHGAEAAQR-FILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLE 305
Query: 274 SFCAYQ-------RSLNVED----DEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPV 322
SFC +Q R L +DP D A+ ++ DF ++ + T+G+A +
Sbjct: 306 SFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCD--TVGIAYL 363
Query: 323 GGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGY 382
GGVC CV++E G + +AHE+GHNLGM+HD ++CA +
Sbjct: 364 GGVCSAKRKCVLAE------------DNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSH 411
Query: 383 IMSPS--RGTN-GEASWSSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAP 436
IMS +G N + SWSSCS + + K +TCLL D + L H+ P
Sbjct: 412 IMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTV-RLPHK----LP 466
Query: 437 GAIWSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGF-FYAGPALPGTACGN 495
G +SA +QC++L A + + CA L C P L GT CG
Sbjct: 467 GMHYSANEQCQILF--GMNATFCRNMEHL-MCAGLWCLVEGDTSCKTKLDPPLDGTECGA 523
Query: 496 KMWCQGGEC 504
WC+ GEC
Sbjct: 524 DKWCRAGEC 532
>AY692424-1|AAW47397.1| 1117|Homo sapiens ADAMTS6 variant 2 protein.
Length = 1117
Score = 115 bits (277), Expect = 4e-25
Identities = 98/309 (31%), Positives = 147/309 (47%), Gaps = 45/309 (14%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ D+ +L+ +N V LY+ SSLG + + + RL +L +L + K LDS
Sbjct: 265 YHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDS 324
Query: 275 FCAYQRS-LNVEDDED--PE----HWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCL 327
FC +Q+S L+ + D + PE H D A+L++ D + +N + T+GLA V G+C
Sbjct: 325 FCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKN--KPCGTLGLASVAGMCE 382
Query: 328 PAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGY----I 383
P +C ++E D+ G S + +AHEIGHN GM+HDG GN+C G+ +
Sbjct: 383 PERSCSINE----DI--------GLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHGAAKL 430
Query: 384 MSPSRGTN-GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERF---SGAPGAI 439
M+ N SWS+CS + T LD G + NE F + APG +
Sbjct: 431 MAAHITANTNPFSWSACSR------DYITSFLDSGRG-TCLDNEPPKRDFLYPAVAPGQV 483
Query: 440 WSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTAC--GN-- 495
+ A +QC A + G C +L C + + PA GT C GN
Sbjct: 484 YDADEQCR-FQYGATSRQCKYG----EVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIE 538
Query: 496 KMWCQGGEC 504
K WC G+C
Sbjct: 539 KGWCYQGDC 547
Score = 36.7 bits (81), Expect = 0.24
Identities = 28/104 (26%), Positives = 43/104 (41%), Gaps = 9/104 (8%)
Query: 41 REAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRV--WTERGEEKPLSSVD 98
R + +D L + A+G++F L L N VS F V W + G + +D
Sbjct: 70 RRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLD 129
Query: 99 ASCHFL----HASPNAVAAFSACKDHALHGLIVVDNSTYEVRPL 138
+CH+ A S C LHG+I ++ Y + PL
Sbjct: 130 -NCHYTGYLQDQRSTTKVALSNCV--GLHGVIATEDEEYFIEPL 170
>DQ422807-1|ABD72606.1| 1427|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 13 protein.
Length = 1427
Score = 114 bits (275), Expect = 8e-25
Identities = 82/296 (27%), Positives = 123/296 (41%), Gaps = 22/296 (7%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLR 451
+WS CS R + L A D P H PG +SA +QC V
Sbjct: 258 AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP-DAQPGLYYSANEQCRVAF- 315
Query: 452 DADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGEC 504
A + + C L+C T + P L GT CG + WC G C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC 371
>AY055376-1|AAL17652.1| 1427|Homo sapiens von Willebrand
factor-cleaving protease precursor protein.
Length = 1427
Score = 114 bits (275), Expect = 8e-25
Identities = 82/296 (27%), Positives = 123/296 (41%), Gaps = 22/296 (7%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLR 451
+WS CS R + L A D P H PG +SA +QC V
Sbjct: 258 AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP-DAQPGLYYSANEQCRVAF- 315
Query: 452 DADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGEC 504
A + + C L+C T + P L GT CG + WC G C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC 371
>AL593848-11|CAI17258.1| 1371|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1371
Score = 114 bits (275), Expect = 8e-25
Identities = 82/296 (27%), Positives = 123/296 (41%), Gaps = 22/296 (7%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLR 451
+WS CS R + L A D P H PG +SA +QC V
Sbjct: 258 AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP-DAQPGLYYSANEQCRVAF- 315
Query: 452 DADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGEC 504
A + + C L+C T + P L GT CG + WC G C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC 371
>AL593848-10|CAI17256.1| 1427|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1427
Score = 114 bits (275), Expect = 8e-25
Identities = 82/296 (27%), Positives = 123/296 (41%), Gaps = 22/296 (7%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLR 451
+WS CS R + L A D P H PG +SA +QC V
Sbjct: 258 AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP-DAQPGLYYSANEQCRVAF- 315
Query: 452 DADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGEC 504
A + + C L+C T + P L GT CG + WC G C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC 371
>AL158826-24|CAI12850.1| 1427|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1427
Score = 114 bits (275), Expect = 8e-25
Identities = 82/296 (27%), Positives = 123/296 (41%), Gaps = 22/296 (7%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLR 451
+WS CS R + L A D P H PG +SA +QC V
Sbjct: 258 AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP-DAQPGLYYSANEQCRVAF- 315
Query: 452 DADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGEC 504
A + + C L+C T + P L GT CG + WC G C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC 371
>AL158826-22|CAI12851.1| 1371|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1371
Score = 114 bits (275), Expect = 8e-25
Identities = 82/296 (27%), Positives = 123/296 (41%), Gaps = 22/296 (7%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLR 451
+WS CS R + L A D P H PG +SA +QC V
Sbjct: 258 AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP-DAQPGLYYSANEQCRVAF- 315
Query: 452 DADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGEC 504
A + + C L+C T + P L GT CG + WC G C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC 371
>AJ420810-1|CAD12729.1| 1371|Homo sapiens ADAMTS-13 protein, variant
2 protein.
Length = 1371
Score = 114 bits (275), Expect = 8e-25
Identities = 82/296 (27%), Positives = 123/296 (41%), Gaps = 22/296 (7%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLR 451
+WS CS R + L A D P H PG +SA +QC V
Sbjct: 258 AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP-DAQPGLYYSANEQCRVAF- 315
Query: 452 DADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGEC 504
A + + C L+C T + P L GT CG + WC G C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC 371
>AF414401-1|AAL11095.1| 1427|Homo sapiens ADAMTS13 protein.
Length = 1427
Score = 114 bits (275), Expect = 8e-25
Identities = 82/296 (27%), Positives = 123/296 (41%), Gaps = 22/296 (7%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLR 451
+WS CS R + L A D P H PG +SA +QC V
Sbjct: 258 AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP-DAQPGLYYSANEQCRVAF- 315
Query: 452 DADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGEC 504
A + + C L+C T + P L GT CG + WC G C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC 371
>AB069698-1|BAB69487.2| 1427|Homo sapiens von Willebrand
factor-cleaving protease protein.
Length = 1427
Score = 114 bits (275), Expect = 8e-25
Identities = 82/296 (27%), Positives = 123/296 (41%), Gaps = 22/296 (7%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLR 451
+WS CS R + L A D P H PG +SA +QC V
Sbjct: 258 AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP-DAQPGLYYSANEQCRVAF- 315
Query: 452 DADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGEC 504
A + + C L+C T + P L GT CG + WC G C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC 371
>AB209497-1|BAD92734.1| 527|Homo sapiens a disintegrin and
metalloprotease with thrombospondin motifs-7
preproprotein va protein.
Length = 527
Score = 113 bits (272), Expect = 2e-24
Identities = 73/241 (30%), Positives = 116/241 (48%), Gaps = 28/241 (11%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ + + +L +N V L+ S+G I +++VRL LL + DL L S
Sbjct: 222 YHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKS 281
Query: 275 FCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVV 334
FC +Q+S+N++ D P H D A+LL+ D + N R T+GL+ V G+C P +C +
Sbjct: 282 FCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMN--RPCETLGLSHVAGMCQPHRSCSI 339
Query: 335 SEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG---YIMSPSRGTN 391
+E G + +AHE+GH+ G+ HDG+GN C G +IMSP +
Sbjct: 340 NE------------DTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYD 387
Query: 392 -GEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCE 447
+WS CS + + D W CL +D P + + S PG ++ QC
Sbjct: 388 AAPLTWSRCSRQYITRFLDRGWGLCL-------DDPPAKDIIDFPSVPPGVLYDVSHQCR 440
Query: 448 V 448
+
Sbjct: 441 L 441
Score = 35.5 bits (78), Expect = 0.56
Identities = 36/133 (27%), Positives = 51/133 (38%), Gaps = 13/133 (9%)
Query: 38 LLPREAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSV 97
L PR + D P Y GR L N+ L++P F T R + +
Sbjct: 27 LWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHI 86
Query: 98 DA---SCHFLH--ASP---NAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSY 149
A +CH L P +AA SAC L G+ + N Y + PL S R ++
Sbjct: 87 RAHTPACHLLGEVQDPELEGGLAAISAC--DGLKGVFQLSNEDYFIEPLDSAPARPGHA- 143
Query: 150 GRTAHVIRRASPP 162
HV+ + P
Sbjct: 144 --QPHVVYKRQAP 154
>DQ266047-1|ABB70405.1| 570|Homo sapiens ADAMTS16s alternative
splice form protein.
Length = 570
Score = 112 bits (269), Expect = 4e-24
Identities = 86/289 (29%), Positives = 133/289 (46%), Gaps = 32/289 (11%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ ++ +L +N V AL++ ++G +I +++V L LL + L L S
Sbjct: 305 NHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSS 364
Query: 275 FCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVV 334
FC +Q L +D +H A+LL+GLD S +N + T+G AP+ G+C +C +
Sbjct: 365 FCQWQSGLMGKDGTRHDH---AILLTGLDICSWKNEPCD--TLGFAPISGMCSKYRSCTI 419
Query: 335 SEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCAR-DGYIMSPS-RGTNG 392
+E G + +AHE GHN GM HDG GN C + +G IMSP+ G NG
Sbjct: 420 NE------------DTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNG 467
Query: 393 EASWSSCSARVV---ADLKWATCLLDGDDGEEDIPNELQHERF-SGAPGAIWSAKKQCEV 448
SWS CS + + A CL D P ++ ++ PG ++ A QC+
Sbjct: 468 VFSWSPCSRQYLHKFLSTAQAICLADQ-------PKPVKEYKYPEKLPGELYDANTQCK- 519
Query: 449 LLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTACGNKM 497
+ + A ++ C L C R PA GT CG+ M
Sbjct: 520 -WQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDM 567
>BC132735-1|AAI32736.1| 1205|Homo sapiens ADAMTS3 protein protein.
Length = 1205
Score = 109 bits (262), Expect = 3e-23
Identities = 95/323 (29%), Positives = 136/323 (42%), Gaps = 42/323 (13%)
Query: 190 GPASYTIEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSL 249
G Y IE+ L +D++ + FH E +++ LL +N V +Y SLG HI + L
Sbjct: 252 GENDYNIEVLLGVDDSVVR-----FHGKE-HVQNYLLTLMNIVNEIYHDESLGVHINVVL 305
Query: 250 VRLTLLR-SQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEE 308
VR+ +L ++ L + L++ C + D EH D A+ L+ DF
Sbjct: 306 VRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPA- 364
Query: 309 NGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGM 368
G+ G APV G+C P +C ++ GF+S +++AHE GH LGM
Sbjct: 365 -----GM-QGYAPVTGMCHPVRSCTLNH------------EDGFSSAFVVAHETGHVLGM 406
Query: 369 HHDGTGNTCARD---GYIMSP-SRGTNGEASWSSCSARVVAD-LKWATCLLDGDDGEEDI 423
HDG GN C + G +M+P + WS CS + + + CLLD D + D
Sbjct: 407 EHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLD-DPFDHDW 465
Query: 424 PNELQHERFSGAPGAIWSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFY 483
P + PG +S +QC C QL C P F
Sbjct: 466 P------KLPELPGINYSMDEQCR--FDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCK 517
Query: 484 A--GPALPGTACGNKMWCQGGEC 504
GP L GT C WC G C
Sbjct: 518 TKKGPPLDGTECAAGKWCYKGHC 540
Score = 34.7 bits (76), Expect = 0.99
Identities = 16/37 (43%), Positives = 26/37 (70%)
Query: 44 QSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSP 80
+S+ D S++ L +N AFG++F L+L PN +LV+P
Sbjct: 68 RSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAP 104
>BC130287-1|AAI30288.1| 1205|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 3 protein.
Length = 1205
Score = 109 bits (262), Expect = 3e-23
Identities = 95/323 (29%), Positives = 136/323 (42%), Gaps = 42/323 (13%)
Query: 190 GPASYTIEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSL 249
G Y IE+ L +D++ + FH E +++ LL +N V +Y SLG HI + L
Sbjct: 252 GENDYNIEVLLGVDDSVVR-----FHGKE-HVQNYLLTLMNIVNEIYHDESLGVHINVVL 305
Query: 250 VRLTLLR-SQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEE 308
VR+ +L ++ L + L++ C + D EH D A+ L+ DF
Sbjct: 306 VRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPA- 364
Query: 309 NGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGM 368
G+ G APV G+C P +C ++ GF+S +++AHE GH LGM
Sbjct: 365 -----GM-QGYAPVTGMCHPVRSCTLNH------------EDGFSSAFVVAHETGHVLGM 406
Query: 369 HHDGTGNTCARD---GYIMSP-SRGTNGEASWSSCSARVVAD-LKWATCLLDGDDGEEDI 423
HDG GN C + G +M+P + WS CS + + + CLLD D + D
Sbjct: 407 EHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLD-DPFDHDW 465
Query: 424 PNELQHERFSGAPGAIWSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFY 483
P + PG +S +QC C QL C P F
Sbjct: 466 P------KLPELPGINYSMDEQCR--FDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCK 517
Query: 484 A--GPALPGTACGNKMWCQGGEC 504
GP L GT C WC G C
Sbjct: 518 TKKGPPLDGTECAAGKWCYKGHC 540
Score = 34.7 bits (76), Expect = 0.99
Identities = 16/37 (43%), Positives = 26/37 (70%)
Query: 44 QSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSP 80
+S+ D S++ L +N AFG++F L+L PN +LV+P
Sbjct: 68 RSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAP 104
>AB002364-1|BAA20821.1| 1201|Homo sapiens KIAA0366 protein.
Length = 1201
Score = 109 bits (262), Expect = 3e-23
Identities = 95/323 (29%), Positives = 136/323 (42%), Gaps = 42/323 (13%)
Query: 190 GPASYTIEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSL 249
G Y IE+ L +D++ + FH E +++ LL +N V +Y SLG HI + L
Sbjct: 248 GENDYNIEVLLGVDDSVVR-----FHGKE-HVQNYLLTLMNIVNEIYHDESLGVHINVVL 301
Query: 250 VRLTLLR-SQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEE 308
VR+ +L ++ L + L++ C + D EH D A+ L+ DF
Sbjct: 302 VRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPA- 360
Query: 309 NGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGM 368
G+ G APV G+C P +C ++ GF+S +++AHE GH LGM
Sbjct: 361 -----GM-QGYAPVTGMCHPVRSCTLNH------------EDGFSSAFVVAHETGHVLGM 402
Query: 369 HHDGTGNTCARD---GYIMSP-SRGTNGEASWSSCSARVVAD-LKWATCLLDGDDGEEDI 423
HDG GN C + G +M+P + WS CS + + + CLLD D + D
Sbjct: 403 EHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLD-DPFDHDW 461
Query: 424 PNELQHERFSGAPGAIWSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFY 483
P + PG +S +QC C QL C P F
Sbjct: 462 P------KLPELPGINYSMDEQCR--FDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCK 513
Query: 484 A--GPALPGTACGNKMWCQGGEC 504
GP L GT C WC G C
Sbjct: 514 TKKGPPLDGTECAAGKWCYKGHC 536
Score = 34.7 bits (76), Expect = 0.99
Identities = 16/37 (43%), Positives = 26/37 (70%)
Query: 44 QSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSP 80
+S+ D S++ L +N AFG++F L+L PN +LV+P
Sbjct: 64 RSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAP 100
>BC109114-1|AAI09115.1| 950|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 15 protein.
Length = 950
Score = 108 bits (260), Expect = 5e-23
Identities = 124/490 (25%), Positives = 192/490 (39%), Gaps = 73/490 (14%)
Query: 53 DVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDAS---CHF---LHA 106
D L + AF +F L L P+ + ++P F + L+ + C + ++A
Sbjct: 50 DQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNA 109
Query: 107 SPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVI-RRASP--PS 163
P++ AA S C L G + Y + PLP+ A + AH++ RR P PS
Sbjct: 110 EPDSFAAVSLCG--GLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPS 167
Query: 164 XXXXXXXXXXXX--------------XXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKI 209
+ G A + I ++ E
Sbjct: 168 GDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYV-ETLVVA 226
Query: 210 FHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERG 269
++ ADL LL + LY+H S+ I + +V++ LLR + +
Sbjct: 227 DESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAA 286
Query: 270 KLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPA 329
L +FCA+Q+ LN D+ PE+WD A+L + D G T+G+A VG +C P
Sbjct: 287 LTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLC----GATTCDTLGMADVGTMCDPK 342
Query: 330 HACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC------ARDGYI 383
+C V E G S + AHE+GH M HD C R ++
Sbjct: 343 RSCSVIE------------DDGLPSAFTTAHELGHVFNMPHDNV-KVCEEVFGKLRANHM 389
Query: 384 MSPSRGTNGEAS-WSSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPGAI 439
MSP+ A+ WS+CSA ++ D CLLD +P +L PGA
Sbjct: 390 MSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDL--------PGAS 441
Query: 440 WSAKKQCEVLLR-DADAAPWSGGGDQ---RGQC-AQLACRTPHRAGFFYAGPALPGTACG 494
++ +QCE+ + P+ + G+ Q+ C+T H P GT+CG
Sbjct: 442 YTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRH-------FPWADGTSCG 494
Query: 495 NKMWCQGGEC 504
C G C
Sbjct: 495 EGKLCLKGAC 504
>AJ315733-1|CAC86014.1| 950|Homo sapiens metalloprotease
disintegrin 15 with thrombospondin domains protein.
Length = 950
Score = 108 bits (260), Expect = 5e-23
Identities = 124/490 (25%), Positives = 192/490 (39%), Gaps = 73/490 (14%)
Query: 53 DVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDAS---CHF---LHA 106
D L + AF +F L L P+ + ++P F + L+ + C + ++A
Sbjct: 50 DQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNA 109
Query: 107 SPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVI-RRASP--PS 163
P++ AA S C L G + Y + PLP+ A + AH++ RR P PS
Sbjct: 110 EPDSFAAVSLCG--GLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPS 167
Query: 164 XXXXXXXXXXXX--------------XXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKI 209
+ G A + I ++ E
Sbjct: 168 GDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYV-ETLVVA 226
Query: 210 FHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERG 269
++ ADL LL + LY+H S+ I + +V++ LLR + +
Sbjct: 227 DESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAA 286
Query: 270 KLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPA 329
L +FCA+Q+ LN D+ PE+WD A+L + D G T+G+A VG +C P
Sbjct: 287 LTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLC----GATTCDTLGMADVGTMCDPK 342
Query: 330 HACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC------ARDGYI 383
+C V E G S + AHE+GH M HD C R ++
Sbjct: 343 RSCSVIE------------DDGLPSAFTTAHELGHVFNMPHDNV-KVCEEVFGKLRANHM 389
Query: 384 MSPSRGTNGEAS-WSSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPGAI 439
MSP+ A+ WS+CSA ++ D CLLD +P +L PGA
Sbjct: 390 MSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDL--------PGAS 441
Query: 440 WSAKKQCEVLLR-DADAAPWSGGGDQ---RGQC-AQLACRTPHRAGFFYAGPALPGTACG 494
++ +QCE+ + P+ + G+ Q+ C+T H P GT+CG
Sbjct: 442 YTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRH-------FPWADGTSCG 494
Query: 495 NKMWCQGGEC 504
C G C
Sbjct: 495 EGKLCLKGAC 504
>AJ311904-1|CAC84565.1| 1207|Homo sapiens ADAMTS-19 protein.
Length = 1207
Score = 108 bits (259), Expect = 7e-23
Identities = 135/557 (24%), Positives = 218/557 (39%), Gaps = 90/557 (16%)
Query: 36 PALLPREAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTE-------- 87
P P AQ + + D+V L AF R+ L L + R ++P F V
Sbjct: 148 PPPSPPPAQHA-EPDGDEVLL--RIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPT 204
Query: 88 --RGEEKPLSSVDASCHFLHA---SPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGV 142
+P + DA C + A P ++A+FS C L G I ++ + PL +
Sbjct: 205 GAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCGG-GLMGFIQLNEDFIFIEPLNDTM 263
Query: 143 ---GRAENSYGRTAHVIRRASPPSXXXXXXXXXXXXXXXXXXXXXXXXKKG-------PA 192
G Y + + + + S +G P
Sbjct: 264 AITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKIAESGRGKRYSYKLPQ 323
Query: 193 SYTIEIALFLDEAAYKIFHPFFHYNEADL-RDMLLAYINGVQALYQHSSLGTHIQLSLVR 251
Y IE + D A Y+ AD R +L +N V L+QH SLG + L +++
Sbjct: 324 EYNIETVVVADPAMVS-------YHGADAARRFILTILNMVFNLFQHKSLGVQVNLRVIK 376
Query: 252 LTLLRSQPTDLSAHAERGKLLDSFCAYQR-----------SLNVEDDEDPEHWDMALLLS 300
L LL P +L K+L+SFC +Q ++ ED D A+L++
Sbjct: 377 LILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILIT 436
Query: 301 GLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAH 360
DF ++ + T+G+A + G+C C+++E G + +AH
Sbjct: 437 RKDFCVHKDEPCD--TVGIAYLSGMCSEKRKCIIAE------------DNGLNLAFTIAH 482
Query: 361 EIGHNLGMHHDGTGNTCARDGYIMSPS--RGTN-GEASWSSCSARVVADL---KWATCLL 414
E+GHN+G++HD +CA +IMS +G N G+ SWS CS + K + CLL
Sbjct: 483 EMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLL 542
Query: 415 DGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACR 474
+ + + + + PG ++A +QC++L A + Q C L C+
Sbjct: 543 --QTNPQSVNSVMVPSKL---PGMTYTADEQCQILF--GPLASFC-QEMQHVICTGLWCK 594
Query: 475 TP-HRAGFFYAGPALPGTACGNKMWCQGGECXXXXXXXXXXXXXXXXAGMAEGESGGWTV 533
+ P + GT C WC+ GEC E +G W++
Sbjct: 595 VEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSA-------------PEHLAGEWSL 641
Query: 534 WR--EGACRSGCSAKSR 548
W C +G S++ R
Sbjct: 642 WSPCSRTCSAGISSRER 658
>AY044847-1|AAL02262.1| 837|Homo sapiens aggrecanase 1 protein.
Length = 837
Score = 107 bits (258), Expect = 9e-23
Identities = 109/416 (26%), Positives = 164/416 (39%), Gaps = 56/416 (13%)
Query: 104 LHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPS 163
++ P +VA+ AL G++ + ++PL G + G AH++RR SP S
Sbjct: 132 INGDPESVASLH-WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG--AHILRRKSPAS 188
Query: 164 XXXXXXXXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRD 223
+ + + + D+ A FH A L+
Sbjct: 189 GQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMA--AFHG------AGLKR 240
Query: 224 MLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLN 283
LL + ++H S+ + L + RL +L S + L SFCA+QR LN
Sbjct: 241 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 300
Query: 284 VEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVL 343
+D DP+H+D A+L + D G T+G+A VG VC PA +C + E
Sbjct: 301 TPEDSDPDHFDTAILFTRQDLC----GVSTCDTLGMADVGTVCDPARSCAIVE------- 349
Query: 344 GRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRG-TNGEASW 396
G S + AHE+GH M HD + + +G ++M+P + E W
Sbjct: 350 -----DDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPW 404
Query: 397 SSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL-RD 452
S CSAR + D + CLLD + +P PG + A +QC++ D
Sbjct: 405 SPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTF--------PGKDYDADRQCQLTFGPD 456
Query: 453 ADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA----GPALPGTACGNKMWCQGGEC 504
+ P CA L C + H G P GT CG C GG C
Sbjct: 457 SRHCP-----QLPPPCAALWC-SGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC 506
>AL590714-6|CAH72146.1| 837|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 4 protein.
Length = 837
Score = 107 bits (258), Expect = 9e-23
Identities = 109/416 (26%), Positives = 164/416 (39%), Gaps = 56/416 (13%)
Query: 104 LHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPS 163
++ P +VA+ AL G++ + ++PL G + G AH++RR SP S
Sbjct: 132 INGDPESVASLH-WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG--AHILRRKSPAS 188
Query: 164 XXXXXXXXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRD 223
+ + + + D+ A FH A L+
Sbjct: 189 GQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMA--AFHG------AGLKR 240
Query: 224 MLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLN 283
LL + ++H S+ + L + RL +L S + L SFCA+QR LN
Sbjct: 241 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 300
Query: 284 VEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVL 343
+D DP+H+D A+L + D G T+G+A VG VC PA +C + E
Sbjct: 301 TPEDSDPDHFDTAILFTRQDLC----GVSTCDTLGMADVGTVCDPARSCAIVE------- 349
Query: 344 GRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRG-TNGEASW 396
G S + AHE+GH M HD + + +G ++M+P + E W
Sbjct: 350 -----DDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPW 404
Query: 397 SSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL-RD 452
S CSAR + D + CLLD + +P PG + A +QC++ D
Sbjct: 405 SPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTF--------PGKDYDADRQCQLTFGPD 456
Query: 453 ADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA----GPALPGTACGNKMWCQGGEC 504
+ P CA L C + H G P GT CG C GG C
Sbjct: 457 SRHCP-----QLPPPCAALWC-SGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC 506
>AF148213-1|AAD41494.1| 837|Homo sapiens aggrecanase-1 protein.
Length = 837
Score = 107 bits (258), Expect = 9e-23
Identities = 109/416 (26%), Positives = 164/416 (39%), Gaps = 56/416 (13%)
Query: 104 LHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPS 163
++ P +VA+ AL G++ + ++PL G + G AH++RR SP S
Sbjct: 132 INGDPESVASLH-WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG--AHILRRKSPAS 188
Query: 164 XXXXXXXXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRD 223
+ + + + D+ A FH A L+
Sbjct: 189 GQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMA--AFHG------AGLKR 240
Query: 224 MLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLN 283
LL + ++H S+ + L + RL +L S + L SFCA+QR LN
Sbjct: 241 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 300
Query: 284 VEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVL 343
+D DP+H+D A+L + D G T+G+A VG VC PA +C + E
Sbjct: 301 TPEDSDPDHFDTAILFTRQDLC----GVSTCDTLGMADVGTVCDPARSCAIVE------- 349
Query: 344 GRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRG-TNGEASW 396
G S + AHE+GH M HD + + +G ++M+P + E W
Sbjct: 350 -----DDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPW 404
Query: 397 SSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL-RD 452
S CSAR + D + CLLD + +P PG + A +QC++ D
Sbjct: 405 SPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTF--------PGKDYDADRQCQLTFGPD 456
Query: 453 ADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA----GPALPGTACGNKMWCQGGEC 504
+ P CA L C + H G P GT CG C GG C
Sbjct: 457 SRHCP-----QLPPPCAALWC-SGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC 506
>AB014588-1|BAA31663.2| 849|Homo sapiens KIAA0688 protein protein.
Length = 849
Score = 107 bits (258), Expect = 9e-23
Identities = 109/416 (26%), Positives = 164/416 (39%), Gaps = 56/416 (13%)
Query: 104 LHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPS 163
++ P +VA+ AL G++ + ++PL G + G AH++RR SP S
Sbjct: 144 INGDPESVASLH-WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG--AHILRRKSPAS 200
Query: 164 XXXXXXXXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRD 223
+ + + + D+ A FH A L+
Sbjct: 201 GQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMA--AFHG------AGLKR 252
Query: 224 MLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLN 283
LL + ++H S+ + L + RL +L S + L SFCA+QR LN
Sbjct: 253 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 312
Query: 284 VEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVL 343
+D DP+H+D A+L + D G T+G+A VG VC PA +C + E
Sbjct: 313 TPEDSDPDHFDTAILFTRQDLC----GVSTCDTLGMADVGTVCDPARSCAIVE------- 361
Query: 344 GRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRG-TNGEASW 396
G S + AHE+GH M HD + + +G ++M+P + E W
Sbjct: 362 -----DDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPW 416
Query: 397 SSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL-RD 452
S CSAR + D + CLLD + +P PG + A +QC++ D
Sbjct: 417 SPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTF--------PGKDYDADRQCQLTFGPD 468
Query: 453 ADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA----GPALPGTACGNKMWCQGGEC 504
+ P CA L C + H G P GT CG C GG C
Sbjct: 469 SRHCP-----QLPPPCAALWC-SGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC 518
>AF488804-1|AAO15766.1| 1911|Homo sapiens a disintegrin-like and
metalloprotease with thrombospondin type 1 motifs 20
protein.
Length = 1911
Score = 106 bits (255), Expect = 2e-22
Identities = 83/297 (27%), Positives = 139/297 (46%), Gaps = 39/297 (13%)
Query: 219 ADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAY 278
++L++ +L ++ V +Y+ S+G I + +V+L ++ + + + L +FC++
Sbjct: 277 SNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSW 336
Query: 279 QRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFG 338
Q++ N DD P H D A+L++ D S + + N T+GL+ +G +C P +C ++E
Sbjct: 337 QQTQNDLDDVHPSHHDTAVLITREDICSSKE-KCN--TLGLSYLGTICDPLQSCFINE-- 391
Query: 339 ATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT---GNTCARDGYIMSPSRGTN-GEA 394
G S + +AHE+GH LG+ HD ++M+P+ +
Sbjct: 392 ----------EKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMSPW 441
Query: 395 SWSSCSARVVA---DLKWATCLLDGDDGE-EDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
SWS+CS + V D + CLLD D E ++P+EL PG+ + KQCE+
Sbjct: 442 SWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSEL--------PGSRYDGNKQCELAF 493
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTP---HRAGFFYAGPALPGTACGNKMWCQGGEC 504
P S C L C + H+ F P GT CG M C+ G C
Sbjct: 494 -----GPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLC 545
>AY358886-1|AAQ89245.1| 837|Homo sapiens ADAMTS4 protein.
Length = 837
Score = 105 bits (251), Expect = 6e-22
Identities = 108/416 (25%), Positives = 163/416 (39%), Gaps = 56/416 (13%)
Query: 104 LHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPS 163
++ P +VA+ AL G++ + ++PL G + G AH++RR SP S
Sbjct: 132 INGDPESVASLH-WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG--AHILRRKSPAS 188
Query: 164 XXXXXXXXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRD 223
+ + + + D+ A FH A L+
Sbjct: 189 GQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMA--AFHG------AGLKR 240
Query: 224 MLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLN 283
LL + ++H S+ + L + RL +L S + L SFCA+QR LN
Sbjct: 241 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 300
Query: 284 VEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVL 343
+D P+H+D A+L + D G T+G+A VG VC PA +C + E
Sbjct: 301 TPEDSGPDHFDTAILFTRQDLC----GVSTCDTLGMADVGTVCDPARSCAIVE------- 349
Query: 344 GRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRG-TNGEASW 396
G S + AHE+GH M HD + + +G ++M+P + E W
Sbjct: 350 -----DDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPW 404
Query: 397 SSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL-RD 452
S CSAR + D + CLLD + +P PG + A +QC++ D
Sbjct: 405 SPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTF--------PGKDYDADRQCQLTFGPD 456
Query: 453 ADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA----GPALPGTACGNKMWCQGGEC 504
+ P CA L C + H G P GT CG C GG C
Sbjct: 457 SRHCP-----QLPPPCAALWC-SGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC 506
>BC063293-1|AAH63293.1| 837|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 4 protein.
Length = 837
Score = 104 bits (249), Expect = 1e-21
Identities = 107/416 (25%), Positives = 164/416 (39%), Gaps = 56/416 (13%)
Query: 104 LHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPS 163
++ P +VA+ AL G++ + ++PL G + G AH++RR SP S
Sbjct: 132 INGDPESVASLH-WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG--AHILRRKSPAS 188
Query: 164 XXXXXXXXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRD 223
+ + + + D+ A FH A L+
Sbjct: 189 GQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMA--AFHG------AGLKR 240
Query: 224 MLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLN 283
LL + ++H S+ + L + RL +L S + L SFCA+QR LN
Sbjct: 241 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 300
Query: 284 VEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVL 343
++ DP+H+D A+L + D G T+G+A VG VC PA +C + E
Sbjct: 301 TPENSDPDHFDTAILFTRQDLC----GVSTCDTLGMADVGTVCDPARSCAIVE------- 349
Query: 344 GRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRG-TNGEASW 396
G S + AHE+GH + HD + + +G ++M+P + E W
Sbjct: 350 -----DDGLQSAFTAAHELGHVFNVLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPW 404
Query: 397 SSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL-RD 452
S CSAR + D + CLLD + +P PG + A +QC++ D
Sbjct: 405 SPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTF--------PGKDYDADRQCQLTFGPD 456
Query: 453 ADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA----GPALPGTACGNKMWCQGGEC 504
+ P CA L C + H G P GT CG C GG C
Sbjct: 457 SRHCP-----QLPPPCAALWC-SGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC 506
>AJ515154-1|CAD56160.2| 1502|Homo sapiens ADAMTS-20 protein protein.
Length = 1502
Score = 103 bits (248), Expect = 1e-21
Identities = 81/297 (27%), Positives = 138/297 (46%), Gaps = 39/297 (13%)
Query: 219 ADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAY 278
++L++ +L ++ V +Y+ S+G I + +V+L ++ + + + L +FC++
Sbjct: 277 SNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSW 336
Query: 279 QRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFG 338
Q++ N DD P H D A+L++ D S + + N +GL+ +G +C P +C ++E
Sbjct: 337 QQTQNDLDDVHPSHHDTAVLITRYDICSSKE-KCN--MLGLSYLGTICDPLQSCFINE-- 391
Query: 339 ATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT---GNTCARDGYIMSPSRGTN-GEA 394
G S + +AHE+GH LG+ HD ++M+P+ +
Sbjct: 392 ----------EKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMSPW 441
Query: 395 SWSSCSARVVADL---KWATCLLDGDDGE-EDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
SWS+CS + V + + CLLD D E ++P+EL PG+ + KQCE+
Sbjct: 442 SWSNCSRKYVTEFLETGYGECLLDKPDEEIYNLPSEL--------PGSRYDGNKQCELAF 493
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTP---HRAGFFYAGPALPGTACGNKMWCQGGEC 504
P S C L C + H+ F P GT CG M C+ G C
Sbjct: 494 -----GPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLC 545
>AJ515153-1|CAD56159.3| 1908|Homo sapiens ADAMTS-20 protein protein.
Length = 1908
Score = 103 bits (248), Expect = 1e-21
Identities = 81/297 (27%), Positives = 138/297 (46%), Gaps = 39/297 (13%)
Query: 219 ADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAY 278
++L++ +L ++ V +Y+ S+G I + +V+L ++ + + + L +FC++
Sbjct: 277 SNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSW 336
Query: 279 QRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFG 338
Q++ N DD P H D A+L++ D S + + N +GL+ +G +C P +C ++E
Sbjct: 337 QQTQNDLDDVHPSHHDTAVLITRYDICSSKE-KCN--MLGLSYLGTICDPLQSCFINE-- 391
Query: 339 ATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT---GNTCARDGYIMSPSRGTN-GEA 394
G S + +AHE+GH LG+ HD ++M+P+ +
Sbjct: 392 ----------EKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMSPW 441
Query: 395 SWSSCSARVVADL---KWATCLLDGDDGE-EDIPNELQHERFSGAPGAIWSAKKQCEVLL 450
SWS+CS + V + + CLLD D E ++P+EL PG+ + KQCE+
Sbjct: 442 SWSNCSRKYVTEFLETGYGECLLDKPDEEIYNLPSEL--------PGSRYDGNKQCELAF 493
Query: 451 RDADAAPWSGGGDQRGQCAQLACRTP---HRAGFFYAGPALPGTACGNKMWCQGGEC 504
P S C L C + H+ F P GT CG M C+ G C
Sbjct: 494 -----GPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLC 545
>AY692425-1|AAW47398.1| 468|Homo sapiens ADAMTS6 variant 3 protein.
Length = 468
Score = 101 bits (243), Expect = 6e-21
Identities = 68/198 (34%), Positives = 106/198 (53%), Gaps = 26/198 (13%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ D+ +L+ +N V LY+ SSLG + + + RL +L +L + K LDS
Sbjct: 265 YHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDS 324
Query: 275 FCAYQRS-LNVEDDED--PE----HWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCL 327
FC +Q+S L+ + D + PE H D A+L++ D + +N + T+GLA V G+C
Sbjct: 325 FCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKN--KPCGTLGLASVAGMCE 382
Query: 328 PAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGY----I 383
P +C ++E D+ G S + +AHEIGHN GM+HDG GN+C G+ +
Sbjct: 383 PERSCSINE----DI--------GLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKL 430
Query: 384 MSPSRGTN-GEASWSSCS 400
M+ N SWS+CS
Sbjct: 431 MAAHITANTNPFSWSACS 448
Score = 36.7 bits (81), Expect = 0.24
Identities = 28/104 (26%), Positives = 43/104 (41%), Gaps = 9/104 (8%)
Query: 41 REAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRV--WTERGEEKPLSSVD 98
R + +D L + A+G++F L L N VS F V W + G + +D
Sbjct: 70 RRSMDPIDPQQAVPKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLD 129
Query: 99 ASCHFL----HASPNAVAAFSACKDHALHGLIVVDNSTYEVRPL 138
+CH+ A S C LHG+I ++ Y + PL
Sbjct: 130 -NCHYTGYLQDQRSTTKVALSNCV--GLHGVIATEDEEYFIEPL 170
>AF163762-1|AAG35563.1| 1077|Homo sapiens zinc metalloendopeptidase
protein.
Length = 1077
Score = 101 bits (243), Expect = 6e-21
Identities = 105/357 (29%), Positives = 157/357 (43%), Gaps = 61/357 (17%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLL-RSQPT-DLSAHAERGKLL 272
++ D+ +LA +N V L+Q SSLG+ + + + RL LL QPT +++ HA GK L
Sbjct: 228 YHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHA--GKSL 285
Query: 273 DSFCAYQRSL-------NVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGV 325
DSFC +Q+S+ N + + D A+L++ D +N + T+GLAPVGG+
Sbjct: 286 DSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKN--KPCGTLGLAPVGGM 343
Query: 326 CLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGY--- 382
C +C V+E D+ G + +AHEIGH GM+HDG GN+C G
Sbjct: 344 CERERSCSVNE----DI--------GLPQAFTIAHEIGHTFGMNHDGVGNSCGARGQDPA 391
Query: 383 -IMSP--SRGTNGEASWSSCSARVVADLKWATCLLDGDDG--EEDIPNELQHERFSGAPG 437
+M+ + TN WSSC+ + T LD G + P + APG
Sbjct: 392 KLMAAHITMKTN-PFVWSSCNR------DYITSFLDSGLGLCLNNRPPRQDFVYPTVAPG 444
Query: 438 AIWSAKKQCEVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTACG--- 494
+ A +QC + + G+ C++L C + + PA GT C
Sbjct: 445 QAYDADEQCR--FQHGVKSRQCKYGE---VCSELWCLSKSNRCITNSIPAAEGTLCQTHT 499
Query: 495 -NKMWCQGGECXXXXXXXXXXXXXXXXAGMAEGESGGWTVWRE--GACRSGCSAKSR 548
+K WC C +G G WT W + C G S+ SR
Sbjct: 500 IDKGWCYKRVCVPFGSRPEG----------VDGAWGPWTPWGDCSRTCGGGVSSSSR 546
Score = 33.5 bits (73), Expect = 2.3
Identities = 32/126 (25%), Positives = 49/126 (38%), Gaps = 7/126 (5%)
Query: 40 PREAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRV--WTERG---EEKPL 94
P Q G+ + L Y + +F L L + RL++ V WT G +
Sbjct: 34 PPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAAR 93
Query: 95 SSVDASCHFLHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAH 154
+ H + ++ A S C LHGLIV D Y + PL G + + H
Sbjct: 94 PHCLYAGHLQGQASSSHVAISTCG--GLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPH 151
Query: 155 VIRRAS 160
V+ + S
Sbjct: 152 VVYKRS 157
>BC113874-1|AAI13875.1| 676|Homo sapiens ADAMTS8 protein protein.
Length = 676
Score = 101 bits (242), Expect = 8e-21
Identities = 94/324 (29%), Positives = 142/324 (43%), Gaps = 47/324 (14%)
Query: 198 IALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRS 257
I LFL+ A F+ ADL++ +L ++ +Y+H S+ I L +V++ ++
Sbjct: 6 IPLFLERVADASMAAFYG---ADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVED 62
Query: 258 QPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTM 317
+ G L +FC +QR N D PEH+D A+LL+ +F +E G + T+
Sbjct: 63 EKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQE-GLCD--TL 119
Query: 318 GLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC 377
G+A +G +C P +C V E G + + LAHE+GH L M HD + C
Sbjct: 120 GVADIGTICDPNKSCSVIE------------DEGLQAAHTLAHELGHVLSMPHDDS-KPC 166
Query: 378 AR------DGYIMSP-SRGTNGEASWSSCSARVVADL---KWATCLLDGDDGEEDIPNEL 427
R ++M+P N WS CSA + +L CLLD +P
Sbjct: 167 TRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLP--- 223
Query: 428 QHERFSGAPG--AIWSAKKQC-EVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA 484
+G PG A++ +QC ++ D P + D CAQL C T +
Sbjct: 224 -----TGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQD---VCAQLWCHTDGAEPLCHT 275
Query: 485 -GPALP---GTACGNKMWCQGGEC 504
+LP GT CG C G C
Sbjct: 276 KNGSLPWADGTPCGPGHLCSEGSC 299
>AF060153-1|AAD48081.1| 890|Homo sapiens METH2 protein protein.
Length = 890
Score = 99.5 bits (237), Expect = 3e-20
Identities = 88/303 (29%), Positives = 134/303 (44%), Gaps = 44/303 (14%)
Query: 219 ADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAY 278
ADL++ +L ++ +Y+H S+ I L +V++ ++ + G L +FC +
Sbjct: 238 ADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNW 297
Query: 279 QRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFG 338
QR N D PEH+D A+LL+ +F +E G + T+G+A +G +C P +C V E
Sbjct: 298 QRRFNQPSDRHPEHYDTAILLTRQNFCGQE-GLCD--TLGVADIGTICDPNKSCSVIE-- 352
Query: 339 ATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCAR------DGYIMSP-SRGTN 391
G + + LAHE+GH L M HD + C R ++M+P N
Sbjct: 353 ----------DEGLQAAHTLAHELGHVLSMPHDDS-KPCTRLFGPMGKHHVMAPLFVHLN 401
Query: 392 GEASWSSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPG--AIWSAKKQC 446
WS CSA + +L CLLD +P +G PG A++ +QC
Sbjct: 402 QTLPWSPCSAMYLTELLDGGHGDCLLDAPGAALPLP--------TGLPGRMALYQLDQQC 453
Query: 447 -EVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA-GPALP---GTACGNKMWCQG 501
++ D P + D CAQL C T + +LP GT CG C
Sbjct: 454 RQIFGPDFRHCPNTSAQD---VCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSE 510
Query: 502 GEC 504
G C
Sbjct: 511 GSC 513
Score = 40.3 bits (90), Expect = 0.020
Identities = 25/96 (26%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDA--SCHF---LHASPNA 110
L + AFG+ F L+L P+ ++PEF++ G + C F ++ P +
Sbjct: 54 LALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPES 113
Query: 111 VAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAE 146
+AA S C+ L G ++D + ++P +G A+
Sbjct: 114 LAAVSLCR--GLSGSFLLDGEEFTIQPQGAGGSLAQ 147
>BC089435-1|AAH89435.1| 918|Homo sapiens ADAMTS8 protein protein.
Length = 918
Score = 99.1 bits (236), Expect = 4e-20
Identities = 88/303 (29%), Positives = 134/303 (44%), Gaps = 44/303 (14%)
Query: 219 ADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAY 278
ADL++ +L ++ +Y+H S+ I L +V++ ++ + G L +FC +
Sbjct: 266 ADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNW 325
Query: 279 QRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFG 338
QR N D PEH+D A+LL+ +F +E G + T+G+A +G +C P +C V E
Sbjct: 326 QRRFNQPSDRHPEHYDTAILLTRQNFCGQE-GLCD--TLGVADIGTICDPNKSCSVIE-- 380
Query: 339 ATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCAR------DGYIMSP-SRGTN 391
G + + LAHE+GH L M HD + C R ++M+P N
Sbjct: 381 ----------DEGLQAAHTLAHELGHVLSMPHDDS-KPCTRLFGPMGKHHVMAPLFVHLN 429
Query: 392 GEASWSSCSARVVADL---KWATCLLDGDDGEEDIPNELQHERFSGAPG--AIWSAKKQC 446
WS CSA + +L CLLD +P +G PG A++ +QC
Sbjct: 430 QTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLP--------TGLPGRMALYQLDQQC 481
Query: 447 -EVLLRDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYA-GPALP---GTACGNKMWCQG 501
++ D P + D CAQL C T + +LP GT CG C
Sbjct: 482 RQIFGPDFRHCPNTSAQD---VCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSE 538
Query: 502 GEC 504
G C
Sbjct: 539 GSC 541
>BC036515-1|AAH36515.1| 967|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 1 protein.
Length = 967
Score = 97.5 bits (232), Expect = 1e-19
Identities = 80/303 (26%), Positives = 126/303 (41%), Gaps = 44/303 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
++ + L+ LL + LY+H S+ + L +V++ ++ + + L +F
Sbjct: 273 FHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNF 332
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q+ N D D EH+D A+L + D G + T+G+A VG VC P+ +C V
Sbjct: 333 CNWQKQHNPPSDRDAEHYDTAILFTRQDLC----GSQTCDTLGMADVGTVCDPSRSCSVI 388
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHD-----GTGNTCARDGYIM-SPSRG 389
E G + + AHE+GH M HD + N +D ++M S
Sbjct: 389 E------------DDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSN 436
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
+ WS CSA ++ D CL+D +P +L PG + A +QC
Sbjct: 437 LDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDL--------PGTSYDANRQC 488
Query: 447 EVLL-RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG----PALPGTACGNKMWCQG 501
+ D+ P D C+ L C T G P GT+CG WC
Sbjct: 489 QFTFGEDSKHCP-----DAASTCSTLWC-TGTSGGVLVCQTKHFPWADGTSCGEGKWCIN 542
Query: 502 GEC 504
G+C
Sbjct: 543 GKC 545
Score = 40.7 bits (91), Expect = 0.015
Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 62 AFGRNFDLQLVPNRRLVSPEF---RVWTERGEEKPLSSVD-ASCHF---LHASPNAVAAF 114
AF + DL+L P+ ++P F V + G E PL D A C + ++ P++ AA
Sbjct: 80 AFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAAL 139
Query: 115 SACKDHALHGLIVVDNSTYEVRPLPSGVGR 144
S C+ + G + Y ++PLP+ R
Sbjct: 140 SLCE--GVRGAFYLLGEAYFIQPLPAASER 167
>AP001697-1|BAA95502.1| 967|Homo sapiens metalloprotease with
thrombospondin type 1 motifs protein.
Length = 967
Score = 97.5 bits (232), Expect = 1e-19
Identities = 80/303 (26%), Positives = 126/303 (41%), Gaps = 44/303 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
++ + L+ LL + LY+H S+ + L +V++ ++ + + L +F
Sbjct: 273 FHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNF 332
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q+ N D D EH+D A+L + D G + T+G+A VG VC P+ +C V
Sbjct: 333 CNWQKQHNPPSDRDAEHYDTAILFTRQDLC----GSQTCDTLGMADVGTVCDPSRSCSVI 388
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHD-----GTGNTCARDGYIM-SPSRG 389
E G + + AHE+GH M HD + N +D ++M S
Sbjct: 389 E------------DDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSN 436
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
+ WS CSA ++ D CL+D +P +L PG + A +QC
Sbjct: 437 LDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDL--------PGTSYDANRQC 488
Query: 447 EVLL-RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG----PALPGTACGNKMWCQG 501
+ D+ P D C+ L C T G P GT+CG WC
Sbjct: 489 QFTFGEDSKHCP-----DAASTCSTLWC-TGTSGGVLVCQTKHFPWADGTSCGEGKWCIN 542
Query: 502 GEC 504
G+C
Sbjct: 543 GKC 545
Score = 40.7 bits (91), Expect = 0.015
Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 62 AFGRNFDLQLVPNRRLVSPEF---RVWTERGEEKPLSSVD-ASCHF---LHASPNAVAAF 114
AF + DL+L P+ ++P F V + G E PL D A C + ++ P++ AA
Sbjct: 80 AFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAAL 139
Query: 115 SACKDHALHGLIVVDNSTYEVRPLPSGVGR 144
S C+ + G + Y ++PLP+ R
Sbjct: 140 SLCE--GVRGAFYLLGEAYFIQPLPAASER 167
>AF207664-1|AAF23772.1| 967|Homo sapiens matrix metalloprotease
protein.
Length = 967
Score = 97.5 bits (232), Expect = 1e-19
Identities = 80/303 (26%), Positives = 126/303 (41%), Gaps = 44/303 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
++ + L+ LL + LY+H S+ + L +V++ ++ + + L +F
Sbjct: 273 FHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNF 332
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q+ N D D EH+D A+L + D G + T+G+A VG VC P+ +C V
Sbjct: 333 CNWQKQHNPPSDRDAEHYDTAILFTRQDLC----GSQTCDTLGMADVGTVCDPSRSCSVI 388
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHD-----GTGNTCARDGYIM-SPSRG 389
E G + + AHE+GH M HD + N +D ++M S
Sbjct: 389 E------------DDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSN 436
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
+ WS CSA ++ D CL+D +P +L PG + A +QC
Sbjct: 437 LDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDL--------PGTSYDANRQC 488
Query: 447 EVLL-RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG----PALPGTACGNKMWCQG 501
+ D+ P D C+ L C T G P GT+CG WC
Sbjct: 489 QFTFGEDSKHCP-----DAASTCSTLWC-TGTSGGVLVCQTKHFPWADGTSCGEGKWCIN 542
Query: 502 GEC 504
G+C
Sbjct: 543 GKC 545
Score = 40.7 bits (91), Expect = 0.015
Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 62 AFGRNFDLQLVPNRRLVSPEF---RVWTERGEEKPLSSVD-ASCHF---LHASPNAVAAF 114
AF + DL+L P+ ++P F V + G E PL D A C + ++ P++ AA
Sbjct: 80 AFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAAL 139
Query: 115 SACKDHALHGLIVVDNSTYEVRPLPSGVGR 144
S C+ + G + Y ++PLP+ R
Sbjct: 140 SLCE--GVRGAFYLLGEAYFIQPLPAASER 167
>AF060152-1|AAD48080.1| 950|Homo sapiens METH1 protein protein.
Length = 950
Score = 97.5 bits (232), Expect = 1e-19
Identities = 80/303 (26%), Positives = 126/303 (41%), Gaps = 44/303 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
++ + L+ LL + LY+H S+ + L +V++ ++ + + L +F
Sbjct: 256 FHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNF 315
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q+ N D D EH+D A+L + D G + T+G+A VG VC P+ +C V
Sbjct: 316 CNWQKQHNPPSDRDAEHYDTAILFTRQDLC----GSQTCDTLGMADVGTVCDPSRSCSVI 371
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHD-----GTGNTCARDGYIM-SPSRG 389
E G + + AHE+GH M HD + N +D ++M S
Sbjct: 372 E------------DDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSN 419
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
+ WS CSA ++ D CL+D +P +L PG + A +QC
Sbjct: 420 LDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDL--------PGTSYDANRQC 471
Query: 447 EVLL-RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG----PALPGTACGNKMWCQG 501
+ D+ P D C+ L C T G P GT+CG WC
Sbjct: 472 QFTFGEDSKHCP-----DAASTCSTLWC-TGTSGGVLVCQTKHFPWADGTSCGEGKWCIN 525
Query: 502 GEC 504
G+C
Sbjct: 526 GKC 528
Score = 40.7 bits (91), Expect = 0.015
Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 62 AFGRNFDLQLVPNRRLVSPEF---RVWTERGEEKPLSSVD-ASCHF---LHASPNAVAAF 114
AF + DL+L P+ ++P F V + G E PL D A C + ++ P++ AA
Sbjct: 63 AFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAAL 122
Query: 115 SACKDHALHGLIVVDNSTYEVRPLPSGVGR 144
S C+ + G + Y ++PLP+ R
Sbjct: 123 SLCE--GVRGAFYLLGEAYFIQPLPAASER 150
>AB037767-1|BAA92584.1| 999|Homo sapiens KIAA1346 protein protein.
Length = 999
Score = 97.5 bits (232), Expect = 1e-19
Identities = 80/303 (26%), Positives = 126/303 (41%), Gaps = 44/303 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
++ + L+ LL + LY+H S+ + L +V++ ++ + + L +F
Sbjct: 305 FHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNF 364
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q+ N D D EH+D A+L + D G + T+G+A VG VC P+ +C V
Sbjct: 365 CNWQKQHNPPSDRDAEHYDTAILFTRQDLC----GSQTCDTLGMADVGTVCDPSRSCSVI 420
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHD-----GTGNTCARDGYIM-SPSRG 389
E G + + AHE+GH M HD + N +D ++M S
Sbjct: 421 E------------DDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSN 468
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
+ WS CSA ++ D CL+D +P +L PG + A +QC
Sbjct: 469 LDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDL--------PGTSYDANRQC 520
Query: 447 EVLL-RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG----PALPGTACGNKMWCQG 501
+ D+ P D C+ L C T G P GT+CG WC
Sbjct: 521 QFTFGEDSKHCP-----DAASTCSTLWC-TGTSGGVLVCQTKHFPWADGTSCGEGKWCIN 574
Query: 502 GEC 504
G+C
Sbjct: 575 GKC 577
Score = 40.7 bits (91), Expect = 0.015
Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 62 AFGRNFDLQLVPNRRLVSPEF---RVWTERGEEKPLSSVD-ASCHF---LHASPNAVAAF 114
AF + DL+L P+ ++P F V + G E PL D A C + ++ P++ AA
Sbjct: 112 AFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAAL 171
Query: 115 SACKDHALHGLIVVDNSTYEVRPLPSGVGR 144
S C+ + G + Y ++PLP+ R
Sbjct: 172 SLCE--GVRGAFYLLGEAYFIQPLPAASER 199
>AF170084-1|AAF15317.1| 967|Homo sapiens metalloproteinase with
thrombospondin type 1 motifs ADAMTS1 protein.
Length = 967
Score = 97.1 bits (231), Expect = 2e-19
Identities = 80/303 (26%), Positives = 126/303 (41%), Gaps = 44/303 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
++ + L+ LL + LY+H S+ + L +V++ ++ + + L +F
Sbjct: 273 FHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNF 332
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q+ N D D EH+D A+L + D G + T+G+A VG VC P+ +C V
Sbjct: 333 CNWQKQHNPPSDRDAEHYDTAILFTRQDLC----GSQTCDTLGMADVGTVCDPSRSCSVI 388
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHD-----GTGNTCARDGYIM-SPSRG 389
E G + + AHE+GH M HD + N +D ++M S
Sbjct: 389 E------------DDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSN 436
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
+ WS CSA ++ D CL+D +P +L PG + A +QC
Sbjct: 437 LDHSQPWSPCSAYMITSFLDNGHGECLMDKPHNPIQLPGDL--------PGTSYDANRQC 488
Query: 447 EVLL-RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG----PALPGTACGNKMWCQG 501
+ D+ P D C+ L C T G P GT+CG WC
Sbjct: 489 QFTFGEDSKHCP-----DAASTCSTLWC-TGTSGGVLVCQTKHFPWADGTSCGEGKWCIN 542
Query: 502 GEC 504
G+C
Sbjct: 543 GKC 545
Score = 40.7 bits (91), Expect = 0.015
Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 62 AFGRNFDLQLVPNRRLVSPEF---RVWTERGEEKPLSSVD-ASCHF---LHASPNAVAAF 114
AF + DL+L P+ ++P F V + G E PL D A C + ++ P++ AA
Sbjct: 80 AFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAAL 139
Query: 115 SACKDHALHGLIVVDNSTYEVRPLPSGVGR 144
S C+ + G + Y ++PLP+ R
Sbjct: 140 SLCE--GVRGAFYLLGEAYFIQPLPAASER 167
>AB209515-1|BAD92752.1| 847|Homo sapiens a disintegrin-like and
metalloprotease (reprolysin type) with thrombospondin ty
protein.
Length = 847
Score = 95.9 bits (228), Expect = 4e-19
Identities = 102/340 (30%), Positives = 149/340 (43%), Gaps = 61/340 (17%)
Query: 232 VQALYQHSSLGTHIQLSLVRLTLL-RSQPT-DLSAHAERGKLLDSFCAYQRSL------- 282
V L+Q SSLG+ + + + RL LL QPT +++ HA GK LDSFC +Q+S+
Sbjct: 25 VAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHA--GKSLDSFCKWQKSIVNHSGHG 82
Query: 283 NVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDV 342
N + + D A+L++ D +N + T+GLAPVGG+C +C V+E D+
Sbjct: 83 NAIPENGVANHDTAVLITRYDICIYKN--KPCGTLGLAPVGGMCERERSCSVNE----DI 136
Query: 343 LGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGY----IMSP--SRGTNGEASW 396
G + + +AHEIGH GM+HDG GN+C G +M+ + TN W
Sbjct: 137 --------GLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTN-PFVW 187
Query: 397 SSCSARVVADLKWATCLLDGDDG--EEDIPNELQHERFSGAPGAIWSAKKQCEVLLRDAD 454
SSCS + T LD G + P + APG + A +QC +
Sbjct: 188 SSCSR------DYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCR--FQHGV 239
Query: 455 AAPWSGGGDQRGQCAQLACRTPHRAGFFYAGPALPGTACG----NKMWCQGGECXXXXXX 510
+ G+ C++L C + + PA GT C +K WC C
Sbjct: 240 KSRQCKYGE---VCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSR 296
Query: 511 XXXXXXXXXXAGMAEGESGGWTVWRE--GACRSGCSAKSR 548
+G G WT W + C G S+ SR
Sbjct: 297 PEG----------VDGAWGPWTPWGDCSRTCGGGVSSSSR 326
>BC093777-1|AAH93777.1| 930|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 5 (aggrecanase-2) protein.
Length = 930
Score = 95.1 bits (226), Expect = 7e-19
Identities = 92/339 (27%), Positives = 140/339 (41%), Gaps = 58/339 (17%)
Query: 221 LRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQR 280
L+ LL + LY H+S+ HI+L++V++ +L + L L +FC +Q
Sbjct: 287 LQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQH 346
Query: 281 SLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGAT 340
N D+ EH+D A+L + D G + T+G+A VG +C P +C V E
Sbjct: 347 QHNQLGDDHEEHYDAAILFTREDLC----GHHSCDTLGMADVGTICSPERSCAVIE---- 398
Query: 341 DVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-------GNTCARDGYIMSPSRGTNGE 393
G + + +AHEIGH LG+ HD + G+T D +MS S T+ +
Sbjct: 399 --------DDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGST--EDKRLMS-SILTSID 447
Query: 394 AS--WSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSG---APGAIWSAKKQCEV 448
AS WS C++ + + DDG + +L ++ G PG + A +QC +
Sbjct: 448 ASKPWSKCTSATITEFL--------DDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNL 499
Query: 449 LL-RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG---PALPGTACGNKMWCQGGEC 504
+ P G D CA+L C + PA+ GT CG C G+C
Sbjct: 500 TFGPEYSVCP---GMD---VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKC 553
Query: 505 XXXXXXXXXXXXXXXXAGMAEGESGGWTVWREGACRSGC 543
+ G G W W G C C
Sbjct: 554 VDKTKKKYYSTS-------SHGNWGSWGSW--GQCSRSC 583
>BC093775-1|AAH93775.1| 930|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 5 (aggrecanase-2) protein.
Length = 930
Score = 95.1 bits (226), Expect = 7e-19
Identities = 92/339 (27%), Positives = 140/339 (41%), Gaps = 58/339 (17%)
Query: 221 LRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQR 280
L+ LL + LY H+S+ HI+L++V++ +L + L L +FC +Q
Sbjct: 287 LQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQH 346
Query: 281 SLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGAT 340
N D+ EH+D A+L + D G + T+G+A VG +C P +C V E
Sbjct: 347 QHNQLGDDHEEHYDAAILFTREDLC----GHHSCDTLGMADVGTICSPERSCAVIE---- 398
Query: 341 DVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-------GNTCARDGYIMSPSRGTNGE 393
G + + +AHEIGH LG+ HD + G+T D +MS S T+ +
Sbjct: 399 --------DDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGST--EDKRLMS-SILTSID 447
Query: 394 AS--WSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSG---APGAIWSAKKQCEV 448
AS WS C++ + + DDG + +L ++ G PG + A +QC +
Sbjct: 448 ASKPWSKCTSATITEFL--------DDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNL 499
Query: 449 LL-RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG---PALPGTACGNKMWCQGGEC 504
+ P G D CA+L C + PA+ GT CG C G+C
Sbjct: 500 TFGPEYSVCP---GMD---VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKC 553
Query: 505 XXXXXXXXXXXXXXXXAGMAEGESGGWTVWREGACRSGC 543
+ G G W W G C C
Sbjct: 554 VDKTKKKYYSTS-------SHGNWGSWGSW--GQCSRSC 583
>AF142099-1|AAD49577.1| 930|Homo sapiens aggrecanase-2 protein.
Length = 930
Score = 95.1 bits (226), Expect = 7e-19
Identities = 92/339 (27%), Positives = 140/339 (41%), Gaps = 58/339 (17%)
Query: 221 LRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQR 280
L+ LL + LY H+S+ HI+L++V++ +L + L L +FC +Q
Sbjct: 287 LQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQH 346
Query: 281 SLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGAT 340
N D+ EH+D A+L + D G + T+G+A VG +C P +C V E
Sbjct: 347 QHNQLGDDHEEHYDAAILFTREDLC----GHHSCDTLGMADVGTICSPERSCAVIE---- 398
Query: 341 DVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-------GNTCARDGYIMSPSRGTNGE 393
G + + +AHEIGH LG+ HD + G+T D +MS S T+ +
Sbjct: 399 --------DDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGST--EDKRLMS-SILTSID 447
Query: 394 AS--WSSCSARVVADLKWATCLLDGDDGEEDIPNELQHERFSG---APGAIWSAKKQCEV 448
AS WS C++ + + DDG + +L ++ G PG + A +QC +
Sbjct: 448 ASKPWSKCTSATITEFL--------DDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNL 499
Query: 449 LL-RDADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG---PALPGTACGNKMWCQGGEC 504
+ P G D CA+L C + PA+ GT CG C G+C
Sbjct: 500 TFGPEYSVCP---GMD---VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKC 553
Query: 505 XXXXXXXXXXXXXXXXAGMAEGESGGWTVWREGACRSGC 543
+ G G W W G C C
Sbjct: 554 VDKTKKKYYSTS-------SHGNWGSWGSW--GQCSRSC 583
>AF140674-1|AAD56357.1| 860|Homo sapiens zinc metalloprotease
ADAMTS6 protein.
Length = 860
Score = 94.3 bits (224), Expect = 1e-18
Identities = 60/172 (34%), Positives = 94/172 (54%), Gaps = 21/172 (12%)
Query: 215 HYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDS 274
++ D+ +L+ +N V LY+ SSLG + + + RL +L +L + K LDS
Sbjct: 265 YHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDS 324
Query: 275 FCAYQRS-LNVEDDED--PE----HWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCL 327
FC +Q+S L+ + D + PE H D A+L++ D + +N + T+GLA V G+C
Sbjct: 325 FCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKN--KPCGTLGLASVAGMCE 382
Query: 328 PAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCAR 379
P +C ++E D+ G S + +AHEI HN GM+HDG GN+C R
Sbjct: 383 PERSCSINE----DI--------GLGSAFTIAHEIVHNFGMNHDGIGNSCGR 422
Score = 36.7 bits (81), Expect = 0.24
Identities = 28/104 (26%), Positives = 43/104 (41%), Gaps = 9/104 (8%)
Query: 41 REAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRV--WTERGEEKPLSSVD 98
R + +D L + A+G++F L L N VS F V W + G + +D
Sbjct: 70 RRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLD 129
Query: 99 ASCHFL----HASPNAVAAFSACKDHALHGLIVVDNSTYEVRPL 138
+CH+ A S C LHG+I ++ Y + PL
Sbjct: 130 -NCHYTGYLQDQRSTTKVALSNCV--GLHGVIATEDEEYFIEPL 170
>AL593848-9|CAI17257.1| 1340|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 13 protein.
Length = 1340
Score = 91.1 bits (216), Expect = 1e-17
Identities = 56/196 (28%), Positives = 90/196 (45%), Gaps = 17/196 (8%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADL 407
+WS CS R + L
Sbjct: 258 AGLAWSPCSRRQLLSL 273
>AL158826-23|CAI12852.1| 1340|Homo sapiens ADAM metallopeptidase
with thrombospondin type 1 motif, 13 protein.
Length = 1340
Score = 91.1 bits (216), Expect = 1e-17
Identities = 56/196 (28%), Positives = 90/196 (45%), Gaps = 17/196 (8%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADL 407
+WS CS R + L
Sbjct: 258 AGLAWSPCSRRQLLSL 273
>AJ420811-1|CAD12730.1| 344|Homo sapiens ADAMTS-13 protein,
truncated variant protein.
Length = 344
Score = 91.1 bits (216), Expect = 1e-17
Identities = 56/196 (28%), Positives = 90/196 (45%), Gaps = 17/196 (8%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADL 407
+WS CS R + L
Sbjct: 258 AGLAWSPCSRRQLLSL 273
>AJ305314-1|CAC83682.1| 1340|Homo sapiens ADAMTS-13 protein protein.
Length = 1340
Score = 91.1 bits (216), Expect = 1e-17
Identities = 56/196 (28%), Positives = 90/196 (45%), Gaps = 17/196 (8%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT-GNTCARDGYIM-SPSRGTN 391
++E GF +AHEIGH+ G+ HDG G+ C G++M S
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR 257
Query: 392 GEASWSSCSARVVADL 407
+WS CS R + L
Sbjct: 258 AGLAWSPCSRRQLLSL 273
>AF175283-1|AAF25806.1| 246|Homo sapiens zinc metalloendopeptidase
protein.
Length = 246
Score = 83.4 bits (197), Expect = 2e-15
Identities = 58/190 (30%), Positives = 92/190 (48%), Gaps = 23/190 (12%)
Query: 219 ADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAY 278
ADL++ +L ++ +Y+H S+ I L +V++ ++ + G L +FC +
Sbjct: 44 ADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNW 103
Query: 279 QRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFG 338
QR N D PEH+D A+LL+ +F +E G + T+G+A +G +C P +C V E
Sbjct: 104 QRRFNQPSDRHPEHYDTAILLTRQNFCGQE-GLCD--TLGVADIGTICDPNKSCSVIE-- 158
Query: 339 ATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCAR------DGYIMSP-SRGTN 391
G + + LAHE+GH L M HD + C R ++M+P N
Sbjct: 159 ----------DEGLQAAHTLAHELGHVLSMPHDDS-KPCTRLFGPMGKHHVMAPLFVHLN 207
Query: 392 GEASWSSCSA 401
WS CSA
Sbjct: 208 QTLPWSPCSA 217
>BC130578-1|AAI30579.1| 1935|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 9 protein.
Length = 1935
Score = 82.6 bits (195), Expect = 4e-15
Identities = 77/301 (25%), Positives = 128/301 (42%), Gaps = 43/301 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
Y+ +L+ +L ++ V ++Y+ S+G I + +V L ++ ++ S L +F
Sbjct: 308 YHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNF 367
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q S N H D A+LL+ D + T+GLA +G +C P +C +S
Sbjct: 368 CQWQHSKN---SPGGIHHDTAVLLTRQDICRAHD---KCDTLGLAELGTICDPYRSCSIS 421
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG-----YIMSPSRG- 389
E +G ++ + +AHE+GH M HD N C +G ++M+P+
Sbjct: 422 E------------DSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEGVKSPQHVMAPTLNF 468
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
WS CS + + D + CLL+ + P +Q PG +++ KQC
Sbjct: 469 YTNPWMWSKCSRKYITEFLDTGYGECLLN-EPESRPYPLPVQ------LPGILYNVNKQC 521
Query: 447 EVLLRDADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGE 503
E++ P S QC +L C H+ P GT C C+ G
Sbjct: 522 ELIF-----GPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGF 576
Query: 504 C 504
C
Sbjct: 577 C 577
>AF488803-1|AAO15765.1| 1935|Homo sapiens a disintegrin-like and
metalloprotease with thrombospondin type 1 motifs 9B
protein.
Length = 1935
Score = 82.6 bits (195), Expect = 4e-15
Identities = 77/301 (25%), Positives = 128/301 (42%), Gaps = 43/301 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
Y+ +L+ +L ++ V ++Y+ S+G I + +V L ++ ++ S L +F
Sbjct: 308 YHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNF 367
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q S N H D A+LL+ D + T+GLA +G +C P +C +S
Sbjct: 368 CQWQHSKN---SPGGIHHDTAVLLTRQDICRAHD---KCDTLGLAELGTICDPYRSCSIS 421
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG-----YIMSPSRG- 389
E +G ++ + +AHE+GH M HD N C +G ++M+P+
Sbjct: 422 E------------DSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEGVKSPQHVMAPTLNF 468
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
WS CS + + D + CLL+ + P +Q PG +++ KQC
Sbjct: 469 YTNPWMWSKCSRKYITEFLDTGYGECLLN-EPESRPYPLPVQ------LPGILYNVNKQC 521
Query: 447 EVLLRDADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGE 503
E++ P S QC +L C H+ P GT C C+ G
Sbjct: 522 ELIF-----GPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGF 576
Query: 504 C 504
C
Sbjct: 577 C 577
>AB037733-1|BAA92550.1| 1471|Homo sapiens KIAA1312 protein protein.
Length = 1471
Score = 82.6 bits (195), Expect = 4e-15
Identities = 77/301 (25%), Positives = 128/301 (42%), Gaps = 43/301 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
Y+ +L+ +L ++ V ++Y+ S+G I + +V L ++ ++ S L +F
Sbjct: 150 YHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNF 209
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q S N H D A+LL+ D + T+GLA +G +C P +C +S
Sbjct: 210 CQWQHSKN---SPGGIHHDTAVLLTRQDICRAHD---KCDTLGLAELGTICDPYRSCSIS 263
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG-----YIMSPSRG- 389
E +G ++ + +AHE+GH M HD N C +G ++M+P+
Sbjct: 264 E------------DSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEGVKSPQHVMAPTLNF 310
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
WS CS + + D + CLL+ + P +Q PG +++ KQC
Sbjct: 311 YTNPWMWSKCSRKYITEFLDTGYGECLLN-EPESRPYPLPVQ------LPGILYNVNKQC 363
Query: 447 EVLLRDADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGE 503
E++ P S QC +L C H+ P GT C C+ G
Sbjct: 364 ELIF-----GPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGF 418
Query: 504 C 504
C
Sbjct: 419 C 419
>AF261918-1|AAF89106.1| 1072|Homo sapiens disintegrin
metalloproteinase with thrombospondin repeats protein.
Length = 1072
Score = 80.2 bits (189), Expect = 2e-14
Identities = 76/301 (25%), Positives = 127/301 (42%), Gaps = 43/301 (14%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
Y+ +L+ +L ++ V ++Y+ S+G I + +V L ++ ++ S L +
Sbjct: 308 YHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNL 367
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVS 335
C +Q S N H D A+LL+ D + T+GLA +G +C P +C +S
Sbjct: 368 CQWQHSKN---SPGGIHHDTAVLLTRQDICRAHD---KCDTLGLAELGTICDPYRSCSIS 421
Query: 336 EFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG-----YIMSPSRG- 389
E +G ++ + +AHE+GH M HD N C +G ++M+P+
Sbjct: 422 E------------DSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEGVKSPQHVMAPTLNF 468
Query: 390 TNGEASWSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQC 446
WS CS + + D + CLL+ + P +Q PG +++ KQC
Sbjct: 469 YTNPWMWSKCSRKYITEFLDTGYGECLLN-EPESRPYPLPVQ------LPGILYNVNKQC 521
Query: 447 EVLLRDADAAPWSGGGDQRGQCAQLACRT---PHRAGFFYAGPALPGTACGNKMWCQGGE 503
E++ P S QC +L C H+ P GT C C+ G
Sbjct: 522 ELIF-----GPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGF 576
Query: 504 C 504
C
Sbjct: 577 C 577
>AP001698-1|BAA95504.1| 412|Homo sapiens disintegrin-like and
metalloprotease with thrombospondin type 1 motif, 5
protein.
Length = 412
Score = 67.3 bits (157), Expect = 2e-10
Identities = 36/116 (31%), Positives = 58/116 (50%), Gaps = 4/116 (3%)
Query: 221 LRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQR 280
L+ LL + LY H+S+ HI+L++V++ +L + L L +FC +Q
Sbjct: 287 LQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQH 346
Query: 281 SLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSE 336
N D+ EH+D A+L + D G + T+G+A VG +C P +C V E
Sbjct: 347 QHNQLGDDHEEHYDAAILFTREDLC----GHHSCDTLGMADVGTICSPERSCAVIE 398
>BC103829-1|AAI03830.1| 276|Homo sapiens ADAMTS13 protein protein.
Length = 276
Score = 65.3 bits (152), Expect = 6e-10
Identities = 50/199 (25%), Positives = 83/199 (41%), Gaps = 17/199 (8%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNL-GMHHDGTGNTCARDGYIMSPSRGTNG 392
++E GF +AHEIGH + T + S G
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHRICARPSPATQTRWTKAAAAASSFLSWMG 257
Query: 393 E-ASWSSCSARVVADLKWA 410
+ +W S + RV A W+
Sbjct: 258 QNVAWRSGAPRVAAAPWWS 276
>BC103828-1|AAI03829.1| 276|Homo sapiens ADAMTS13 protein protein.
Length = 276
Score = 65.3 bits (152), Expect = 6e-10
Identities = 50/199 (25%), Positives = 83/199 (41%), Gaps = 17/199 (8%)
Query: 214 FHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLD 273
F ++ D +L +N L + SLG ++ LV++ +L + A L
Sbjct: 93 FQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLL 152
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ G+ +GG C P +C+
Sbjct: 153 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQ---VRGVTQLGGACSPTWSCL 209
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNL-GMHHDGTGNTCARDGYIMSPSRGTNG 392
++E GF +AHEIGH + T + S G
Sbjct: 210 ITE------------DTGFDLGVTIAHEIGHRICARPSPATQTRWTKAAAAASSFLSWMG 257
Query: 393 E-ASWSSCSARVVADLKWA 410
+ +W S + RV A W+
Sbjct: 258 QNVAWRSGAPRVAAAPWWS 276
>U41766-1|AAC50403.1| 819|Homo sapiens
metalloprotease/disintegrin/cysteine-rich protein
precursor protein.
Length = 819
Score = 58.0 bits (134), Expect = 9e-08
Identities = 42/106 (39%), Positives = 55/106 (51%), Gaps = 15/106 (14%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHH-DG 372
G T G+A VG VC +HA ++ FG V T I+AHE+GHNLGM+H DG
Sbjct: 310 GGTAGMAFVGTVCSRSHAGGINVFGQITVE---------TFASIVAHELGHNLGMNHDDG 360
Query: 373 TGNTCARDGYIMSPSRGTNGEASWSSCSARVVADL---KWATCLLD 415
+C IM + G +G ++SSCSA L K CLL+
Sbjct: 361 RDCSCGAKSCIM--NSGASGSRNFSSCSAEDFEKLTLNKGGNCLLN 404
Score = 32.3 bits (70), Expect = 5.3
Identities = 23/87 (26%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLS---SVDASCHF---LHASPNAV 111
Y A G+ + L N+ L+ +F V+T E ++ ++ CH+ + N+
Sbjct: 68 YVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSS 127
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPL 138
A S C L GL+ ++N++Y + PL
Sbjct: 128 IALSDC--FGLRGLLHLENASYGIEPL 152
>D14665-1|BAA03499.2| 703|Homo sapiens KIAA0021 protein protein.
Length = 703
Score = 58.0 bits (134), Expect = 9e-08
Identities = 42/106 (39%), Positives = 55/106 (51%), Gaps = 15/106 (14%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHH-DG 372
G T G+A VG VC +HA ++ FG V T I+AHE+GHNLGM+H DG
Sbjct: 194 GGTAGMAFVGTVCSRSHAGGINVFGQITVE---------TFASIVAHELGHNLGMNHDDG 244
Query: 373 TGNTCARDGYIMSPSRGTNGEASWSSCSARVVADL---KWATCLLD 415
+C IM + G +G ++SSCSA L K CLL+
Sbjct: 245 RDCSCGAKSCIM--NSGASGSRNFSSCSAEDFEKLTLNKGGNCLLN 288
>BC126406-1|AAI26407.1| 712|Homo sapiens ADAM9 protein protein.
Length = 712
Score = 58.0 bits (134), Expect = 9e-08
Identities = 42/106 (39%), Positives = 55/106 (51%), Gaps = 15/106 (14%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHH-DG 372
G T G+A VG VC +HA ++ FG V T I+AHE+GHNLGM+H DG
Sbjct: 310 GGTAGMAFVGTVCSRSHAGGINVFGQITVE---------TFASIVAHELGHNLGMNHDDG 360
Query: 373 TGNTCARDGYIMSPSRGTNGEASWSSCSARVVADL---KWATCLLD 415
+C IM + G +G ++SSCSA L K CLL+
Sbjct: 361 RDCSCGAKSCIM--NSGASGSRNFSSCSAEDFEKLTLNKGGNCLLN 404
Score = 32.3 bits (70), Expect = 5.3
Identities = 23/87 (26%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLS---SVDASCHF---LHASPNAV 111
Y A G+ + L N+ L+ +F V+T E ++ ++ CH+ + N+
Sbjct: 68 YVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSS 127
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPL 138
A S C L GL+ ++N++Y + PL
Sbjct: 128 IALSDC--FGLRGLLHLENASYGIEPL 152
>AF495383-1|AAM49575.1| 655|Homo sapiens
disintegrin/metalloproteinase domain 9 short protein
precursor protein.
Length = 655
Score = 58.0 bits (134), Expect = 9e-08
Identities = 42/106 (39%), Positives = 55/106 (51%), Gaps = 15/106 (14%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHH-DG 372
G T G+A VG VC +HA ++ FG V T I+AHE+GHNLGM+H DG
Sbjct: 310 GGTAGMAFVGTVCSRSHAGGINVFGQITVE---------TFASIVAHELGHNLGMNHDDG 360
Query: 373 TGNTCARDGYIMSPSRGTNGEASWSSCSARVVADL---KWATCLLD 415
+C IM + G +G ++SSCSA L K CLL+
Sbjct: 361 RDCSCGAKSCIM--NSGASGSRNFSSCSAEDFEKLTLNKGGNCLLN 404
Score = 32.3 bits (70), Expect = 5.3
Identities = 23/87 (26%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLS---SVDASCHF---LHASPNAV 111
Y A G+ + L N+ L+ +F V+T E ++ ++ CH+ + N+
Sbjct: 68 YVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSS 127
Query: 112 AAFSACKDHALHGLIVVDNSTYEVRPL 138
A S C L GL+ ++N++Y + PL
Sbjct: 128 IALSDC--FGLRGLLHLENASYGIEPL 152
>BC030812-1|AAH30812.1| 339|Homo sapiens ADAMTS4 protein protein.
Length = 339
Score = 57.6 bits (133), Expect = 1e-07
Identities = 48/197 (24%), Positives = 80/197 (40%), Gaps = 11/197 (5%)
Query: 104 LHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPS 163
++ P +VA+ AL G++ + ++PL G + G AH++RR SP S
Sbjct: 132 INGDPESVASLH-WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG--AHILRRKSPAS 188
Query: 164 XXXXXXXXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRD 223
+ + + + D+ A FH A L+
Sbjct: 189 GQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMA--AFHG------AGLKR 240
Query: 224 MLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLN 283
LL + ++H S+ + L + RL +L S + L SFCA+QR LN
Sbjct: 241 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 300
Query: 284 VEDDEDPEHWDMALLLS 300
+D DP+H+D A+L +
Sbjct: 301 TPEDSDPDHFDTAILFT 317
>AL590714-7|CAH72147.1| 339|Homo sapiens ADAM metallopeptidase with
thrombospondin type 1 motif, 4 protein.
Length = 339
Score = 57.6 bits (133), Expect = 1e-07
Identities = 48/197 (24%), Positives = 80/197 (40%), Gaps = 11/197 (5%)
Query: 104 LHASPNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPS 163
++ P +VA+ AL G++ + ++PL G + G AH++RR SP S
Sbjct: 132 INGDPESVASLH-WDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG--AHILRRKSPAS 188
Query: 164 XXXXXXXXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRD 223
+ + + + D+ A FH A L+
Sbjct: 189 GQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMA--AFHG------AGLKR 240
Query: 224 MLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLN 283
LL + ++H S+ + L + RL +L S + L SFCA+QR LN
Sbjct: 241 YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN 300
Query: 284 VEDDEDPEHWDMALLLS 300
+D DP+H+D A+L +
Sbjct: 301 TPEDSDPDHFDTAILFT 317
>AY532929-1|AAS54901.1| 90|Homo sapiens von Willebrand
factor-cleaving protease protein.
Length = 90
Score = 49.2 bits (112), Expect = 4e-05
Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 15/91 (16%)
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
S C + +++N EDD DP H D+ L ++ D + R+ V + +GG C P +C+
Sbjct: 15 SVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRV---VTQLGGACSPTWSCL 71
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGH 364
++E GF +AHEIGH
Sbjct: 72 ITE------------DTGFDLGVTIAHEIGH 90
>D26579-1|BAA05626.1| 824|Homo sapiens transmembrane protein
protein.
Length = 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 88/386 (22%), Positives = 144/386 (37%), Gaps = 54/386 (13%)
Query: 33 VYLPALLP----REAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEF-RVWTE 87
V LP LP R A S G + + + Y A G NF L L NR L+ + +T
Sbjct: 31 VVLPRRLPGPRVRRALPSHLGLHPE-RVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTA 89
Query: 88 RGEEKPLSSVDASCHFLHAS-----PNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGV 142
+ H L+ P++ A+ S C L G V + + + PL G
Sbjct: 90 ANGSEVTEQPRGQDHCLYQGHVEGYPDSAASLSTCA--GLRGFFQVGSDLHLIEPLDEGG 147
Query: 143 GRAENSYGRTAHVIRRASPPSXXXXXXXXXXXXXXXXXXXXXXXXKKGPASYT--IEIAL 200
++ + H+++ A P+ T +E+ +
Sbjct: 148 EGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSL-PSRETRYVELYV 206
Query: 201 FLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPT 260
+D A +++ +EA +R +L +N V LYQ + ++ LV L + SQ
Sbjct: 207 VVDNAEFQMLG-----SEAAVRHRVLEVVNHVDKLYQK----LNFRVVLVGLEIWNSQDR 257
Query: 261 DLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLA 320
+ L++ +Q D L++G+DF G T+G A
Sbjct: 258 -FHVSPDPSVTLENLLTWQARQRTRRHLH----DNVQLITGVDF--------TGTTVGFA 304
Query: 321 PVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC-AR 379
V +C + V + V G +AHE+GHNLGM HD C +
Sbjct: 305 RVSAMCSHSSGAVNQDHSKNPV--------GVACT--MAHEMGHNLGMDHDENVQGCRCQ 354
Query: 380 DGY-----IMSPSRGTNGEASWSSCS 400
+ + IM+ S G++ +S CS
Sbjct: 355 ERFEAGRCIMAGSIGSSFPRMFSDCS 380
>AK129873-1|BAC85245.1| 226|Homo sapiens protein ( Homo sapiens
cDNA FLJ26363 fis, clone HRT05360, highly similar to
ADAM-TS 1 PRECURSOR (EC 3.4.24.-). ).
Length = 226
Score = 47.2 bits (107), Expect = 2e-04
Identities = 22/88 (25%), Positives = 43/88 (48%)
Query: 216 YNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSF 275
++ + L+ LL + LY+H S+ + L +V++ ++ + + L +F
Sbjct: 35 FHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNF 94
Query: 276 CAYQRSLNVEDDEDPEHWDMALLLSGLD 303
C +Q+ N D D EH+D A+L + D
Sbjct: 95 CNWQKQHNPPSDRDAEHYDTAILFTRQD 122
>BC115404-1|AAI15405.1| 824|Homo sapiens ADAM8 protein protein.
Length = 824
Score = 46.0 bits (104), Expect = 4e-04
Identities = 87/386 (22%), Positives = 143/386 (37%), Gaps = 54/386 (13%)
Query: 33 VYLPALLP----REAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEF-RVWTE 87
V LP LP R A S G + + + Y A G NF L L NR L+ + +T
Sbjct: 31 VVLPRRLPGPRVRRALPSHLGLHPE-RVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTA 89
Query: 88 RGEEKPLSSVDASCHFLHAS-----PNAVAAFSACKDHALHGLIVVDNSTYEVRPLPSGV 142
+ H + P++ A+ S C L G V + + + PL G
Sbjct: 90 ANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCA--GLRGFFQVGSDLHLIEPLDEGG 147
Query: 143 GRAENSYGRTAHVIRRASPPSXXXXXXXXXXXXXXXXXXXXXXXXKKGPASYT--IEIAL 200
++ + H+++ A P+ T +E+ +
Sbjct: 148 EGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSL-PSRETRYVELYV 206
Query: 201 FLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPT 260
+D A +++ +EA +R +L +N V LYQ + ++ LV L + SQ
Sbjct: 207 VVDNAEFQMLG-----SEAAVRHRVLEVVNHVDKLYQK----LNFRVVLVGLEIWNSQDR 257
Query: 261 DLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLA 320
+ L++ +Q D L++G+DF G T+G A
Sbjct: 258 -FHVSPDPSVTLENLLTWQARQRTRRHLH----DNVQLITGVDF--------TGTTVGFA 304
Query: 321 PVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC-AR 379
V +C + V + V G +AHE+GHNLGM HD C +
Sbjct: 305 RVSAMCSHSSGAVNQDHSKNPV--------GVACT--MAHEMGHNLGMDHDENVQGCRCQ 354
Query: 380 DGY-----IMSPSRGTNGEASWSSCS 400
+ + IM+ S G++ +S CS
Sbjct: 355 ERFEAGRCIMAGSIGSSFPRMFSDCS 380
>AF215824-1|AAG43987.1| 754|Homo sapiens a disintegrin and
metalloproteinase 7 protein.
Length = 754
Score = 46.0 bits (104), Expect = 4e-04
Identities = 59/225 (26%), Positives = 100/225 (44%), Gaps = 38/225 (16%)
Query: 196 IEIALFLDEAAYKIF-HPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTL 254
+E+ + D+ Y+ HP +N+ LR+ + +N V +Y+ +L H+ L + +
Sbjct: 201 VELFIVADDTVYRRNGHP---HNK--LRNRIWGMVNFVNMIYK--TLNIHVTLVGIEIWT 253
Query: 255 LRSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNG 314
+L ++ E L SF ++ L D +D +LLSG YS
Sbjct: 254 -HEDKIELYSNIETTLLRFSFWQ-EKILKTRKD-----FDHVVLLSGKWLYSH------- 299
Query: 315 VTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTG 374
G++ GG+CLP ++ T ++ P + +AH++GHNLGM HD
Sbjct: 300 -VQGISYPGGMCLPYYS--------TSIIKDLLPDTNIIANR-MAHQLGHNLGMQHDEFP 349
Query: 375 NTCARDGYIMSPSRGTNGEASWSSCSA----RVVADLKWATCLLD 415
TC G + S G+ +S CS + + D K TC+L+
Sbjct: 350 CTCP-SGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYK-PTCMLN 392
>BC043207-1|AAH43207.2| 559|Homo sapiens ADAM7 protein protein.
Length = 559
Score = 44.4 bits (100), Expect = 0.001
Identities = 53/199 (26%), Positives = 87/199 (43%), Gaps = 32/199 (16%)
Query: 221 LRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQR 280
LR+ + +N V +Y+ +L H+ L + + +L ++ E L SF ++
Sbjct: 37 LRNRIWGMVNFVNMIYK--TLNIHVTLVGIEIWT-HEDKIELYSNIETTLLRFSFWQ-EK 92
Query: 281 SLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGAT 340
L D +D +LLSG YS G++ GG+CLP ++ T
Sbjct: 93 ILKTRKD-----FDHVVLLSGKWLYSH--------VQGISYPGGMCLPYYS--------T 131
Query: 341 DVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGYIMSPSRGTNGEASWSSCS 400
++ P + +AH++GHNLGM HD TC G + S G+ +S CS
Sbjct: 132 SIIKDLLPDTNIIANR-MAHQLGHNLGMQHDEFPCTCP-SGKCVMDSDGSIPALKFSKCS 189
Query: 401 A----RVVADLKWATCLLD 415
+ + D K TC+L+
Sbjct: 190 QNQYHQYLKDYK-PTCMLN 207
>U46005-1|AAC51112.1| 814|Homo sapiens MDC15 protein.
Length = 814
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>U41767-1|AAC50404.1| 814|Homo sapiens metargidin precursor
protein.
Length = 814
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>BT009764-1|AAP88766.1| 814|Homo sapiens a disintegrin and
metalloproteinase domain 15 (metargidin) protein.
Length = 814
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>BC014566-1|AAH14566.1| 814|Homo sapiens ADAM metallopeptidase
domain 15 (metargidin) protein.
Length = 814
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY576417-1|AAS73000.1| 797|Homo sapiens ADAM15 isoform 8 protein.
Length = 797
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY560601-1|AAS72999.1| 822|Homo sapiens ADAM15 isoform 7b protein.
Length = 822
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY560600-1|AAS72998.1| 821|Homo sapiens ADAM15 isoform 7a protein.
Length = 821
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY560599-1|AAS72997.1| 863|Homo sapiens ADAM15 isoform 6b protein.
Length = 863
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY560598-1|AAS72996.1| 862|Homo sapiens ADAM15 isoform 6a protein.
Length = 862
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY560597-1|AAS72995.1| 838|Homo sapiens ADAM15 isoform 5 protein.
Length = 838
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY560596-1|AAS72994.1| 839|Homo sapiens ADAM15 isoform 4a protein.
Length = 839
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY560595-1|AAS72993.1| 796|Homo sapiens ADAM15 isoform 3a protein.
Length = 796
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY560594-1|AAS72992.1| 814|Homo sapiens ADAM15 isoform 2 protein.
Length = 814
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY560593-1|AAS72991.1| 772|Homo sapiens ADAM15 isoform 1 protein.
Length = 772
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AY518542-1|AAR99331.1| 772|Homo sapiens ADAM-15 precursor protein.
Length = 772
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AL691442-13|CAI15327.1| 814|Homo sapiens ADAM metallopeptidase
domain 15 (metargidin) protein.
Length = 814
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AL451085-35|CAI13274.1| 814|Homo sapiens ADAM metallopeptidase
domain 15 (metargidin) protein.
Length = 814
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-11|AAS72298.1| 797|Homo sapiens ADAM15 isoform 8 protein.
Length = 797
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-10|AAS48596.1| 821|Homo sapiens ADAM15 isoform 7a
protein.
Length = 821
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-9|AAS48597.1| 822|Homo sapiens ADAM15 isoform 7b protein.
Length = 822
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-8|AAS48590.1| 772|Homo sapiens ADAM15 isoform 1 protein.
Length = 772
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-7|AAS48591.1| 796|Homo sapiens ADAM15 isoform 3a protein.
Length = 796
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-6|AAM44189.1| 814|Homo sapiens ADAM15 isoform 2 protein.
Length = 814
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-5|AAS48593.1| 838|Homo sapiens ADAM15 isoform 5 protein.
Length = 838
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-4|AAS48594.1| 862|Homo sapiens ADAM15 isoform 6a protein.
Length = 862
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-3|AAS48592.1| 839|Homo sapiens ADAM15 isoform 4a protein.
Length = 839
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AF314227-2|AAS48595.1| 863|Homo sapiens ADAM15 isoform 6b protein.
Length = 863
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 286 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 341
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 342 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 396
Query: 403 VV 404
+
Sbjct: 397 AL 398
>AB209157-1|BAD92394.1| 859|Homo sapiens ADAM15 isoform 6a variant
protein.
Length = 859
Score = 43.6 bits (98), Expect = 0.002
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 18/122 (14%)
Query: 292 HWDMALLLSGLDFYSEE--NGRR-NGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYP 348
HW A LL L S + G +G T+G+A +C P + V+ +T +LG
Sbjct: 283 HWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILG---- 338
Query: 349 SAGFTSVYILAHEIGHNLGMHHDGTGNTCARDG------YIMSPSRGTNGEASWSSCSAR 402
+AHE+GH+LG+ HD GN+C G IM S ++S+CS R
Sbjct: 339 -----VASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRR 393
Query: 403 VV 404
+
Sbjct: 394 AL 395
>DQ995342-1|ABI97387.1| 813|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 813
Score = 43.2 bits (97), Expect = 0.003
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 13/93 (13%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+GLAPV G+C + VS TD P +A +AHEIGH+LG+ HD
Sbjct: 308 GATVGLAPVEGMCRAESSGGVS----TDHSELPIGAAA-----TMAHEIGHSLGLSHDPD 358
Query: 374 G----NTCARDGYIMSPSRGTNGEASWSSCSAR 402
G G +M+ + G +S+CS R
Sbjct: 359 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRR 391
>AY358314-1|AAQ88680.1| 813|Homo sapiens Adam33 protein.
Length = 813
Score = 43.2 bits (97), Expect = 0.003
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 13/93 (13%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+GLAPV G+C + VS TD P +A +AHEIGH+LG+ HD
Sbjct: 308 GATVGLAPVEGMCRAESSGGVS----TDHSELPIGAAA-----TMAHEIGHSLGLSHDPD 358
Query: 374 G----NTCARDGYIMSPSRGTNGEASWSSCSAR 402
G G +M+ + G +S+CS R
Sbjct: 359 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRR 391
>AL356755-2|CAI23465.1| 813|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 813
Score = 43.2 bits (97), Expect = 0.003
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 13/93 (13%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+GLAPV G+C + VS TD P +A +AHEIGH+LG+ HD
Sbjct: 308 GATVGLAPVEGMCRAESSGGVS----TDHSELPIGAAA-----TMAHEIGHSLGLSHDPD 358
Query: 374 G----NTCARDGYIMSPSRGTNGEASWSSCSAR 402
G G +M+ + G +S+CS R
Sbjct: 359 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRR 391
>AL356755-1|CAM28348.1| 812|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 812
Score = 43.2 bits (97), Expect = 0.003
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 13/93 (13%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+GLAPV G+C + VS TD P +A +AHEIGH+LG+ HD
Sbjct: 308 GATVGLAPVEGMCRAESSGGVS----TDHSELPIGAAA-----TMAHEIGHSLGLSHDPD 358
Query: 374 G----NTCARDGYIMSPSRGTNGEASWSSCSAR 402
G G +M+ + G +S+CS R
Sbjct: 359 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRR 391
>AL109804-2|CAI18840.1| 813|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 813
Score = 43.2 bits (97), Expect = 0.003
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 13/93 (13%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+GLAPV G+C + VS TD P +A +AHEIGH+LG+ HD
Sbjct: 308 GATVGLAPVEGMCRAESSGGVS----TDHSELPIGAAA-----TMAHEIGHSLGLSHDPD 358
Query: 374 G----NTCARDGYIMSPSRGTNGEASWSSCSAR 402
G G +M+ + G +S+CS R
Sbjct: 359 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRR 391
>AL109804-1|CAM26955.1| 812|Homo sapiens ADAM metallopeptidase
domain 33 protein.
Length = 812
Score = 43.2 bits (97), Expect = 0.003
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 13/93 (13%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+GLAPV G+C + VS TD P +A +AHEIGH+LG+ HD
Sbjct: 308 GATVGLAPVEGMCRAESSGGVS----TDHSELPIGAAA-----TMAHEIGHSLGLSHDPD 358
Query: 374 G----NTCARDGYIMSPSRGTNGEASWSSCSAR 402
G G +M+ + G +S+CS R
Sbjct: 359 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRR 391
>AF466288-1|AAM80483.1| 812|Homo sapiens a disintegrin and
metalloprotease domain 33 protein.
Length = 812
Score = 43.2 bits (97), Expect = 0.003
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 13/93 (13%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+GLAPV G+C + VS TD P +A +AHEIGH+LG+ HD
Sbjct: 308 GATVGLAPVEGMCRAESSGGVS----TDHSELPIGAAA-----TMAHEIGHSLGLSHDPD 358
Query: 374 G----NTCARDGYIMSPSRGTNGEASWSSCSAR 402
G G +M+ + G +S+CS R
Sbjct: 359 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRR 391
>AF466287-1|AAM80482.1| 812|Homo sapiens a disintegrin and
metalloprotease domain 33 protein.
Length = 812
Score = 43.2 bits (97), Expect = 0.003
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 13/93 (13%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+GLAPV G+C + VS TD P +A +AHEIGH+LG+ HD
Sbjct: 308 GATVGLAPVEGMCRAESSGGVS----TDHSELPIGAAA-----TMAHEIGHSLGLSHDPD 358
Query: 374 G----NTCARDGYIMSPSRGTNGEASWSSCSAR 402
G G +M+ + G +S+CS R
Sbjct: 359 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRR 391
>AB055891-1|BAB83092.1| 813|Homo sapiens metalloprotease
disintegrin protein.
Length = 813
Score = 43.2 bits (97), Expect = 0.003
Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 13/93 (13%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+GLAPV G+C + VS TD P +A +AHEIGH+LG+ HD
Sbjct: 308 GATVGLAPVEGMCRAESSGGVS----TDHSELPIGAAA-----TMAHEIGHSLGLSHDPD 358
Query: 374 G----NTCARDGYIMSPSRGTNGEASWSSCSAR 402
G G +M+ + G +S+CS R
Sbjct: 359 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRR 391
>AF090327-1|AAC36742.1| 588|Homo sapiens sperm maturation-related
glycoprotein GP-83 protein.
Length = 588
Score = 42.7 bits (96), Expect = 0.004
Identities = 53/205 (25%), Positives = 89/205 (43%), Gaps = 33/205 (16%)
Query: 196 IEIALFLDEAAYKIF-HPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTL 254
+E+ + D+ Y+ HP +N+ LR+ + +N V +Y+ +L H+ L + +
Sbjct: 35 VELFIVADDTVYRRNGHP---HNK--LRNRIWGMVNFVNMIYK--TLNIHVTLVGIEIWT 87
Query: 255 LRSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNG 314
+L ++ E L SF ++ L D +D +LLSG YS
Sbjct: 88 -HEDKIELYSNIETTLLRFSFWQ-EKILKTRKD-----FDHVVLLSGKWLYSH------- 133
Query: 315 VTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTG 374
G++ GG+CLP ++ T ++ P + +AH++GHNLGM HD
Sbjct: 134 -VQGISYPGGMCLPYYS--------TSIIKDLLPDTNIIANR-MAHQLGHNLGMQHDEFP 183
Query: 375 NTCARDGYIMSPSRGTNGEASWSSC 399
TC G + S G+ S C
Sbjct: 184 CTCP-SGKCVMDSDGSIPALDLSKC 207
>BC109025-1|AAI09026.1| 721|Homo sapiens ADAM21 protein protein.
Length = 721
Score = 42.3 bits (95), Expect = 0.005
Identities = 79/345 (22%), Positives = 132/345 (38%), Gaps = 48/345 (13%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSS---VDASCHF---LHASPN 109
L Y+ G+ + + + LVS V+T E L + C++ + +P
Sbjct: 60 LSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPE 119
Query: 110 AVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPSXXXXXX 169
++ FSAC G++ + TYE+ P+ Y ++ + +
Sbjct: 120 SLVVFSACFG-GFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKE 178
Query: 170 XXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADL---RDMLL 226
K +T A FL E + H FF Y+++++ ++ +
Sbjct: 179 VARQQLEFEEAENSALEPKSAGDWWTH--AWFL-ELVVVVNHDFFIYSQSNISKVQEDVF 235
Query: 227 AYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLNVED 286
+N V ++YQ LGT+I L + + +G + + ++ LN
Sbjct: 236 LVVNIVDSMYQQ--LGTYIILIGIEIW-------------NQGNVFP-MTSIEQVLN--- 276
Query: 287 DEDPEHWDMALLLSGLDFYSEENGRRNGVT--MGLAPVGGVCLPAHACVVSEF-GATDVL 343
D W + LS L + +N + +GLA V G+C P C V F G T L
Sbjct: 277 --DFSQWKQ-ISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSL 333
Query: 344 GRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGYIMSPSR 388
F + +AHE+GH LGM HD C G IM+ R
Sbjct: 334 --------FANT--VAHELGHTLGMQHDEEFCFCGERGCIMNTFR 368
>BC109024-1|AAI09025.1| 722|Homo sapiens ADAM metallopeptidase
domain 21 protein.
Length = 722
Score = 42.3 bits (95), Expect = 0.005
Identities = 79/345 (22%), Positives = 132/345 (38%), Gaps = 48/345 (13%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSS---VDASCHF---LHASPN 109
L Y+ G+ + + + LVS V+T E L + C++ + +P
Sbjct: 61 LSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPE 120
Query: 110 AVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPSXXXXXX 169
++ FSAC G++ + TYE+ P+ Y ++ + +
Sbjct: 121 SLVVFSACFG-GFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKE 179
Query: 170 XXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADL---RDMLL 226
K +T A FL E + H FF Y+++++ ++ +
Sbjct: 180 VARQQLEFEEAENSALEPKSAGDWWTH--AWFL-ELVVVVNHDFFIYSQSNISKVQEDVF 236
Query: 227 AYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLNVED 286
+N V ++YQ LGT+I L + + +G + + ++ LN
Sbjct: 237 LVVNIVDSMYQQ--LGTYIILIGIEIW-------------NQGNVFP-MTSIEQVLN--- 277
Query: 287 DEDPEHWDMALLLSGLDFYSEENGRRNGVT--MGLAPVGGVCLPAHACVVSEF-GATDVL 343
D W + LS L + +N + +GLA V G+C P C V F G T L
Sbjct: 278 --DFSQWKQ-ISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSL 334
Query: 344 GRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGYIMSPSR 388
F + +AHE+GH LGM HD C G IM+ R
Sbjct: 335 --------FANT--VAHELGHTLGMQHDEEFCFCGERGCIMNTFR 369
>AF158644-1|AAD55255.1| 722|Homo sapiens
metalloproteinase-disintegrin protein.
Length = 722
Score = 42.3 bits (95), Expect = 0.005
Identities = 79/345 (22%), Positives = 132/345 (38%), Gaps = 48/345 (13%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSS---VDASCHF---LHASPN 109
L Y+ G+ + + + LVS V+T E L + C++ + +P
Sbjct: 61 LSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPE 120
Query: 110 AVAAFSACKDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPSXXXXXX 169
++ FSAC G++ + TYE+ P+ Y ++ + +
Sbjct: 121 SLVVFSACFG-GFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKE 179
Query: 170 XXXXXXXXXXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADL---RDMLL 226
K +T A FL E + H FF Y+++++ ++ +
Sbjct: 180 VARQQLEFEEAENSALEPKSAGDWWTH--AWFL-ELVVVVNHDFFIYSQSNISKVQEDVF 236
Query: 227 AYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLNVED 286
+N V ++YQ LGT+I L + + +G + + ++ LN
Sbjct: 237 LVVNIVDSMYQQ--LGTYIILIGIEIW-------------NQGNVFP-MTSIEQVLN--- 277
Query: 287 DEDPEHWDMALLLSGLDFYSEENGRRNGVT--MGLAPVGGVCLPAHACVVSEF-GATDVL 343
D W + LS L + +N + +GLA V G+C P C V F G T L
Sbjct: 278 --DFSQWKQ-ISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSL 334
Query: 344 GRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTCARDGYIMSPSR 388
F + +AHE+GH LGM HD C G IM+ R
Sbjct: 335 --------FANT--VAHELGHTLGMQHDEEFCFCGERGCIMNTFR 369
>BC060804-1|AAH60804.1| 737|Homo sapiens ADAM metallopeptidase
domain 12 (meltrin alpha) protein.
Length = 737
Score = 41.9 bits (94), Expect = 0.007
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 15/95 (15%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+G+AP+ +C + + + + LG + LAHE+GHN GM+HD
Sbjct: 310 GTTIGMAPIMSMCTADQSGGIVMDHSDNPLG---------AAVTLAHELGHNFGMNHDTL 360
Query: 374 GNTCA------RDGYIMSPSRGTNGEASWSSCSAR 402
C+ + G IM+ S G +SSCS +
Sbjct: 361 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRK 395
>AY358878-1|AAQ89237.1| 735|Homo sapiens ADAM-12 protein.
Length = 735
Score = 41.9 bits (94), Expect = 0.007
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 15/95 (15%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+G+AP+ +C + + + + LG + LAHE+GHN GM+HD
Sbjct: 310 GTTIGMAPIMSMCTADQSGGIVMDHSDNPLG---------AAVTLAHELGHNFGMNHDTL 360
Query: 374 GNTCA------RDGYIMSPSRGTNGEASWSSCSAR 402
C+ + G IM+ S G +SSCS +
Sbjct: 361 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRK 395
>AL589787-6|CAI40683.1| 738|Homo sapiens ADAM metallopeptidase
domain 12 (meltrin alpha) protein.
Length = 738
Score = 41.9 bits (94), Expect = 0.007
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 15/95 (15%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+G+AP+ +C + + + + LG + LAHE+GHN GM+HD
Sbjct: 313 GTTIGMAPIMSMCTADQSGGIVMDHSDNPLG---------AAVTLAHELGHNFGMNHDTL 363
Query: 374 GNTCA------RDGYIMSPSRGTNGEASWSSCSAR 402
C+ + G IM+ S G +SSCS +
Sbjct: 364 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRK 398
>AL589787-5|CAI40682.1| 909|Homo sapiens ADAM metallopeptidase
domain 12 (meltrin alpha) protein.
Length = 909
Score = 41.9 bits (94), Expect = 0.007
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 15/95 (15%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+G+AP+ +C + + + + LG + LAHE+GHN GM+HD
Sbjct: 313 GTTIGMAPIMSMCTADQSGGIVMDHSDNPLG---------AAVTLAHELGHNFGMNHDTL 363
Query: 374 GNTCA------RDGYIMSPSRGTNGEASWSSCSAR 402
C+ + G IM+ S G +SSCS +
Sbjct: 364 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRK 398
>AF023477-1|AAC08703.2| 738|Homo sapiens meltrin-S protein.
Length = 738
Score = 41.9 bits (94), Expect = 0.007
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 15/95 (15%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+G+AP+ +C + + + + LG + LAHE+GHN GM+HD
Sbjct: 313 GTTIGMAPIMSMCTADQSGGIVMDHSDNPLG---------AAVTLAHELGHNFGMNHDTL 363
Query: 374 GNTCA------RDGYIMSPSRGTNGEASWSSCSAR 402
C+ + G IM+ S G +SSCS +
Sbjct: 364 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRK 398
>AF023476-1|AAC08702.2| 909|Homo sapiens meltrin-L precursor
protein.
Length = 909
Score = 41.9 bits (94), Expect = 0.007
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 15/95 (15%)
Query: 314 GVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT 373
G T+G+AP+ +C + + + + LG + LAHE+GHN GM+HD
Sbjct: 313 GTTIGMAPIMSMCTADQSGGIVMDHSDNPLG---------AAVTLAHELGHNFGMNHDTL 363
Query: 374 GNTCA------RDGYIMSPSRGTNGEASWSSCSAR 402
C+ + G IM+ S G +SSCS +
Sbjct: 364 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRK 398
>BC125118-1|AAI25119.1| 870|Homo sapiens ADAM metallopeptidase
domain 22 protein.
Length = 870
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 91 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 150
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 151 LSTC--HGLHGMFYDGNHTYLIEP 172
>BC092465-1|AAH92465.1| 342|Homo sapiens ADAM22 protein protein.
Length = 342
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 91 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 150
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 151 LSTC--HGLHGMFYDGNHTYLIEP 172
>BC062433-1|AAH62433.1| 242|Homo sapiens ADAM22 protein protein.
Length = 242
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 90 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 149
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 150 LSTC--HGLHGMFYDGNHTYLIEP 171
>BC036029-1|AAH36029.1| 342|Homo sapiens ADAM22 protein protein.
Length = 342
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 91 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 150
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 151 LSTC--HGLHGMFYDGNHTYLIEP 172
>AF158637-1|AAD55251.1| 867|Homo sapiens
metalloproteinase-disintegrin ADAM22-3 protein.
Length = 867
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 52 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 111
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 112 LSTC--HGLHGMFYDGNHTYLIEP 133
>AF155382-1|AAF73289.1| 906|Homo sapiens metalloprotease-like,
disintegrin-like, cysteine-rich protein 2 epsilon
protein.
Length = 906
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 91 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 150
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 151 LSTC--HGLHGMFYDGNHTYLIEP 172
>AF155381-1|AAF73288.1| 899|Homo sapiens metalloprotease-like,
disintegrin-like, cysteine-rich protein 2 delta protein.
Length = 899
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 91 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 150
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 151 LSTC--HGLHGMFYDGNHTYLIEP 172
>AF073291-1|AAF22476.2| 870|Homo sapiens MDC2 protein.
Length = 870
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 91 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 150
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 151 LSTC--HGLHGMFYDGNHTYLIEP 172
>AB009671-2|BAA32350.1| 823|Homo sapiens MDC2 beta protein.
Length = 823
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 91 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 150
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 151 LSTC--HGLHGMFYDGNHTYLIEP 172
>AB009671-1|BAA32349.1| 859|Homo sapiens MDC2 alpha protein.
Length = 859
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 58 YNFDAFGRNFDLQLVPNRRLVSPEF-RVWTERGEEKPLSSVDASCHF---LHASPNAVAA 113
+ DAFG +F L +V N L+S E+ E G + C++ + +P++ A
Sbjct: 91 FQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVA 150
Query: 114 FSACKDHALHGLIVVDNSTYEVRP 137
S C H LHG+ N TY + P
Sbjct: 151 LSTC--HGLHGMFYDGNHTYLIEP 172
>DQ202398-1|ABA43715.1| 465|Homo sapiens ADAM21-like protein
protein.
Length = 465
Score = 39.9 bits (89), Expect = 0.026
Identities = 28/73 (38%), Positives = 35/73 (47%), Gaps = 11/73 (15%)
Query: 317 MGLAPVGGVCLPAHACVVSEF-GATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGN 375
+GLA + G+C P C V F G T L F + +AHE+GH LGM HD
Sbjct: 137 LGLAYIAGICRPPIDCGVDNFQGDTWSL--------FANT--VAHELGHTLGMQHDEEFC 186
Query: 376 TCARDGYIMSPSR 388
C G IM+ R
Sbjct: 187 FCGERGCIMNTFR 199
>AL162080-1|CAB82413.1| 550|Homo sapiens hypothetical protein
protein.
Length = 550
Score = 39.9 bits (89), Expect = 0.026
Identities = 33/117 (28%), Positives = 45/117 (38%), Gaps = 22/117 (18%)
Query: 396 WSSCSARVVA---DLKWATCLLDGDDGEEDIPNELQHERFSGAPGAIWSAKKQCEVLL-R 451
WS CSA ++ D CL+D +P +L PG + A +QC+
Sbjct: 26 WSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDL--------PGTSYDANRQCQFTFGE 77
Query: 452 DADAAPWSGGGDQRGQCAQLACRTPHRAGFFYAG----PALPGTACGNKMWCQGGEC 504
D+ P D C+ L C T G P GT+CG WC G+C
Sbjct: 78 DSKHCP-----DAASTCSTLWC-TGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKC 128
>AJ242015-1|CAB42085.1| 775|Homo sapiens eMDC II protein protein.
Length = 775
Score = 39.1 bits (87), Expect = 0.046
Identities = 54/205 (26%), Positives = 87/205 (42%), Gaps = 31/205 (15%)
Query: 196 IEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLL 255
IE L LD +K ++ N+ ++R + N V LY+ L TH+ +LV + +
Sbjct: 206 IEYYLVLDNGEFKRYNE----NQDEIRKRVFEMANYVNMLYK--KLNTHV--ALVGMEIW 257
Query: 256 RSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGV 315
+ + L++F ++ S+ H D+A L++ + G
Sbjct: 258 TDKDK-IKITPNASFTLENFSKWRGSVL---SRRKRH-DIAQLITATELA--------GT 304
Query: 316 TMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGN 375
T+GLA + +C P VV + +D L R AG +AHE+GHN GM HD
Sbjct: 305 TVGLAFMSTMCSPYSVGVVQDH--SDNLLRV---AG-----TMAHEMGHNFGMFHDDYSC 354
Query: 376 TCARDGYIMSPSRGTNGEASWSSCS 400
C +M + +SSCS
Sbjct: 355 KCPSTICVMDKALSFYIPTDFSSCS 379
>AF137335-1|AAD25100.1| 540|Homo sapiens metalloprotease
disintegrin cysteine-rich protein, secreted form MDC-Ls
protein.
Length = 540
Score = 39.1 bits (87), Expect = 0.046
Identities = 54/205 (26%), Positives = 87/205 (42%), Gaps = 31/205 (15%)
Query: 196 IEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLL 255
IE L LD +K ++ N+ ++R + N V LY+ L TH+ +LV + +
Sbjct: 206 IEYYLVLDNGEFKRYNE----NQDEIRKRVFEMANYVNMLYK--KLNTHV--ALVGMEIW 257
Query: 256 RSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGV 315
+ + L++F ++ S+ H D+A L++ + G
Sbjct: 258 TDKDK-IKITPNASFTLENFSKWRGSVL---SRRKRH-DIAQLITATELA--------GT 304
Query: 316 TMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGN 375
T+GLA + +C P VV + +D L R AG +AHE+GHN GM HD
Sbjct: 305 TVGLAFMSTMCSPYSVGVVQDH--SDNLLRV---AG-----TMAHEMGHNFGMFHDDYSC 354
Query: 376 TCARDGYIMSPSRGTNGEASWSSCS 400
C +M + +SSCS
Sbjct: 355 KCPSTICVMDKALSFYIPTDFSSCS 379
>AF137334-1|AAD25099.1| 775|Homo sapiens metalloprotease
disintegrin cysteine-rich protein, transmembrane form
MDC-Lm protein.
Length = 775
Score = 39.1 bits (87), Expect = 0.046
Identities = 54/205 (26%), Positives = 87/205 (42%), Gaps = 31/205 (15%)
Query: 196 IEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLL 255
IE L LD +K ++ N+ ++R + N V LY+ L TH+ +LV + +
Sbjct: 206 IEYYLVLDNGEFKRYNE----NQDEIRKRVFEMANYVNMLYK--KLNTHV--ALVGMEIW 257
Query: 256 RSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGV 315
+ + L++F ++ S+ H D+A L++ + G
Sbjct: 258 TDKDK-IKITPNASFTLENFSKWRGSVL---SRRKRH-DIAQLITATELA--------GT 304
Query: 316 TMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGN 375
T+GLA + +C P VV + +D L R AG +AHE+GHN GM HD
Sbjct: 305 TVGLAFMSTMCSPYSVGVVQDH--SDNLLRV---AG-----TMAHEMGHNFGMFHDDYSC 354
Query: 376 TCARDGYIMSPSRGTNGEASWSSCS 400
C +M + +SSCS
Sbjct: 355 KCPSTICVMDKALSFYIPTDFSSCS 379
>AF171931-1|AAF03779.1| 787|Homo sapiens
metallaproteinase-disintegrin gama protein.
Length = 787
Score = 38.7 bits (86), Expect = 0.061
Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 11/83 (13%)
Query: 318 GLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC 377
G+ G+C P +C + F LG T +AH +GHNLGM+HD C
Sbjct: 299 GIGAFRGMCTPHRSCAIVTF-MNKTLG--------TFSIAVAHHLGHNLGMNHDEDTCRC 349
Query: 378 ARDGYIMSPSRGTNGEASWSSCS 400
++ IM G +S+CS
Sbjct: 350 SQPRCIM--HEGNPPITKFSNCS 370
>AF171930-1|AAF03778.1| 766|Homo sapiens
metallaproteinase-disintegrin beta protein.
Length = 766
Score = 38.7 bits (86), Expect = 0.061
Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 11/83 (13%)
Query: 318 GLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC 377
G+ G+C P +C + F LG T +AH +GHNLGM+HD C
Sbjct: 299 GIGAFRGMCTPHRSCAIVTF-MNKTLG--------TFSIAVAHHLGHNLGMNHDEDTCRC 349
Query: 378 ARDGYIMSPSRGTNGEASWSSCS 400
++ IM G +S+CS
Sbjct: 350 SQPRCIM--HEGNPPITKFSNCS 370
>AF171929-1|AAF03777.1| 820|Homo sapiens
metallaproteinase-disintegrin protein.
Length = 820
Score = 38.7 bits (86), Expect = 0.061
Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 11/83 (13%)
Query: 318 GLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC 377
G+ G+C P +C + F LG T +AH +GHNLGM+HD C
Sbjct: 299 GIGAFRGMCTPHRSCAIVTF-MNKTLG--------TFSIAVAHHLGHNLGMNHDEDTCRC 349
Query: 378 ARDGYIMSPSRGTNGEASWSSCS 400
++ IM G +S+CS
Sbjct: 350 SQPRCIM--HEGNPPITKFSNCS 370
>AF134708-1|AAF22163.1| 820|Homo sapiens disintegrin and
metalloproteinase domain 29 protein.
Length = 820
Score = 38.7 bits (86), Expect = 0.061
Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 11/83 (13%)
Query: 318 GLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC 377
G+ G+C P +C + F LG T +AH +GHNLGM+HD C
Sbjct: 299 GIGAFRGMCTPHRSCAIVTF-MNKTLG--------TFSIAVAHHLGHNLGMNHDEDTCRC 349
Query: 378 ARDGYIMSPSRGTNGEASWSSCS 400
++ IM G +S+CS
Sbjct: 350 SQPRCIM--HEGNPPITKFSNCS 370
>AC105914-1|AAY41055.1| 820|Homo sapiens unknown protein.
Length = 820
Score = 38.7 bits (86), Expect = 0.061
Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 11/83 (13%)
Query: 318 GLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNTC 377
G+ G+C P +C + F LG T +AH +GHNLGM+HD C
Sbjct: 299 GIGAFRGMCTPHRSCAIVTF-MNKTLG--------TFSIAVAHHLGHNLGMNHDEDTCRC 349
Query: 378 ARDGYIMSPSRGTNGEASWSSCS 400
++ IM G +S+CS
Sbjct: 350 SQPRCIM--HEGNPPITKFSNCS 370
>Y13786-1|CAC20585.1| 918|Homo sapiens meltrin-beta/ADAM 19
homologue protein.
Length = 918
Score = 37.9 bits (84), Expect = 0.11
Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 25/132 (18%)
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
SF +++R L + ++ D A L++G+ F+ G T+GLAP+ +C +
Sbjct: 281 SFLSWRRKLLAQ-----KYHDNAQLITGMSFH--------GTTIGLAPLMAMCSVYQSGG 327
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT---GNTCARDGYIMSPSRGT 390
V+ + + +G +AHE+GHN GM HD + A G IM+ + G
Sbjct: 328 VNMDHSENAIG---------VAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGH 378
Query: 391 NGEASWSSCSAR 402
++ C+ R
Sbjct: 379 PFPKVFNGCNRR 390
>AF311317-1|AAK07852.1| 918|Homo sapiens disintegrin and
metalloproteinase ADAM19 protein.
Length = 918
Score = 37.9 bits (84), Expect = 0.11
Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 25/132 (18%)
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
SF +++R L + ++ D A L++G+ F+ G T+GLAP+ +C +
Sbjct: 281 SFLSWRRKLLAQ-----KYHDNAQLITGMSFH--------GTTIGLAPLMAMCSVYQSGG 327
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT---GNTCARDGYIMSPSRGT 390
V+ + + +G +AHE+GHN GM HD + A G IM+ + G
Sbjct: 328 VNMDHSENAIG---------VAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGH 378
Query: 391 NGEASWSSCSAR 402
++ C+ R
Sbjct: 379 PFPKVFNGCNRR 390
>AF134707-1|AAF22162.1| 857|Homo sapiens disintegrin and
metalloproteinase domain 19 protein.
Length = 857
Score = 37.9 bits (84), Expect = 0.11
Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 25/132 (18%)
Query: 274 SFCAYQRSLNVEDDEDPEHWDMALLLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACV 333
SF +++R L + ++ D A L++G+ F+ G T+GLAP+ +C +
Sbjct: 183 SFLSWRRKLLAQ-----KYHDNAQLITGMSFH--------GTTIGLAPLMAMCSVYQSGG 229
Query: 334 VSEFGATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGT---GNTCARDGYIMSPSRGT 390
V+ + + +G +AHE+GHN GM HD + A G IM+ + G
Sbjct: 230 VNMDHSENAIG---------VAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGH 280
Query: 391 NGEASWSSCSAR 402
++ C+ R
Sbjct: 281 PFPKVFNGCNRR 292
>AF029900-1|AAC52042.1| 542|Homo sapiens ADAM 21 protein.
Length = 542
Score = 37.9 bits (84), Expect = 0.11
Identities = 28/73 (38%), Positives = 35/73 (47%), Gaps = 11/73 (15%)
Query: 317 MGLAPVGGVCLPAHACVVSEF-GATDVLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGN 375
+GLA V G+C P C V F G T L F + +AHE+G+ LGM HD
Sbjct: 127 LGLAYVAGICRPPIDCGVDNFQGDTWSL--------FANT--VAHELGYTLGMQHDEEFC 176
Query: 376 TCARDGYIMSPSR 388
C G IM+ R
Sbjct: 177 FCGERGCIMNTFR 189
>AK128469-1|BAC87455.1| 327|Homo sapiens protein ( Homo sapiens
cDNA FLJ46613 fis, clone TKIDN2011160, moderately
similar to ADAM-TS 3 precursor (EC 3.4.24.-). ).
Length = 327
Score = 37.1 bits (82), Expect = 0.19
Identities = 25/84 (29%), Positives = 29/84 (34%), Gaps = 15/84 (17%)
Query: 468 CAQLACRTPHRAGFFYA--GPALPGTACGNKMWCQGGECXXXXXXXXXXXXXXXXAGMAE 525
C QL C P F GP L GT C WC G C
Sbjct: 25 CKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC------------IWKSPEQTY 72
Query: 526 GESGGWTVWRE-GACRSGCSAKSR 548
G+ GGW+ W + G+C C R
Sbjct: 73 GQDGGWSSWTKFGSCSRSCGGGVR 96
>AY692426-1|AAW47399.1| 292|Homo sapiens ADAMTS6 variant 4 protein.
Length = 292
Score = 36.7 bits (81), Expect = 0.24
Identities = 28/104 (26%), Positives = 43/104 (41%), Gaps = 9/104 (8%)
Query: 41 REAQSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSPEFRV--WTERGEEKPLSSVD 98
R + +D L + A+G++F L L N VS F V W + G + +D
Sbjct: 70 RRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLD 129
Query: 99 ASCHFL----HASPNAVAAFSACKDHALHGLIVVDNSTYEVRPL 138
+CH+ A S C LHG+I ++ Y + PL
Sbjct: 130 -NCHYTGYLQDQRSTTKVALSNCV--GLHGVIATEDEEYFIEPL 170
>Y13323-1|CAA73764.2| 470|Homo sapiens disintegrin-protease
protein.
Length = 470
Score = 35.9 bits (79), Expect = 0.43
Identities = 72/345 (20%), Positives = 125/345 (36%), Gaps = 41/345 (11%)
Query: 64 GRNFDLQLVPNRRLVSPEFR--VWTERGEEKPLSSVDAS-CHF---LHASPNAVAAFSAC 117
G L L + L+ P++ +++ RGEE + C++ + N+VA+ S C
Sbjct: 84 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 143
Query: 118 KDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPSXXXXXXXXXXXXXX 177
L G + Y+++PL S + + A+
Sbjct: 144 D--GLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRI 201
Query: 178 XXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQ 237
A I++ L LD A YK ++ N +R + +N + +Y
Sbjct: 202 SRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNE----NLTLIRSFVFDVMNLLNVIYN 257
Query: 238 HSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMAL 297
+Q++LV + + S + D+F + S + + D A
Sbjct: 258 TID----VQVALVGMEIW-SDGDKIKVVPSASTTFDNFLRWHSS-----NLGKKIHDHAQ 307
Query: 298 LLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYI 357
LLSG+ F N RR +GLA +C P+ V+ +V V +
Sbjct: 308 LLSGISF----NNRR----VGLAASNSLCSPSSVAVIEAKKKNNV----------ALVGV 349
Query: 358 LAHEIGHNLGMHHDGTGNTCARDGYIMSPSRGTNGEASWS-SCSA 401
++HE+GH LGM C +M+ + +S SC A
Sbjct: 350 MSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRA 394
>BC074878-1|AAH74878.1| 470|Homo sapiens ADAM-like, decysin 1
protein.
Length = 470
Score = 35.9 bits (79), Expect = 0.43
Identities = 72/345 (20%), Positives = 125/345 (36%), Gaps = 41/345 (11%)
Query: 64 GRNFDLQLVPNRRLVSPEFR--VWTERGEEKPLSSVDAS-CHF---LHASPNAVAAFSAC 117
G L L + L+ P++ +++ RGEE + C++ + N+VA+ S C
Sbjct: 84 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 143
Query: 118 KDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPSXXXXXXXXXXXXXX 177
L G + Y+++PL S + + A+
Sbjct: 144 D--GLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRI 201
Query: 178 XXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQ 237
A I++ L LD A YK ++ N +R + +N + +Y
Sbjct: 202 SRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNE----NLTLIRSFVFDVMNLLNVIYN 257
Query: 238 HSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMAL 297
+Q++LV + + S + D+F + S + + D A
Sbjct: 258 TID----VQVALVGMEIW-SDGDKIKVVPSASTTFDNFLRWHSS-----NLGKKIHDHAQ 307
Query: 298 LLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYI 357
LLSG+ F N RR +GLA +C P+ V+ +V V +
Sbjct: 308 LLSGISF----NNRR----VGLAASNSLCSPSSVAVIEAKKKNNV----------ALVGV 349
Query: 358 LAHEIGHNLGMHHDGTGNTCARDGYIMSPSRGTNGEASWS-SCSA 401
++HE+GH LGM C +M+ + +S SC A
Sbjct: 350 MSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRA 394
>BC074877-1|AAH74877.1| 470|Homo sapiens ADAM-like, decysin 1
protein.
Length = 470
Score = 35.9 bits (79), Expect = 0.43
Identities = 72/345 (20%), Positives = 125/345 (36%), Gaps = 41/345 (11%)
Query: 64 GRNFDLQLVPNRRLVSPEFR--VWTERGEEKPLSSVDAS-CHF---LHASPNAVAAFSAC 117
G L L + L+ P++ +++ RGEE + C++ + N+VA+ S C
Sbjct: 84 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 143
Query: 118 KDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPSXXXXXXXXXXXXXX 177
L G + Y+++PL S + + A+
Sbjct: 144 D--GLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRI 201
Query: 178 XXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQ 237
A I++ L LD A YK ++ N +R + +N + +Y
Sbjct: 202 SRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNE----NLTLIRSFVFDVMNLLNVIYN 257
Query: 238 HSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMAL 297
+Q++LV + + S + D+F + S + + D A
Sbjct: 258 TID----VQVALVGMEIW-SDGDKIKVVPSASTTFDNFLRWHSS-----NLGKKIHDHAQ 307
Query: 298 LLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYI 357
LLSG+ F N RR +GLA +C P+ V+ +V V +
Sbjct: 308 LLSGISF----NNRR----VGLAASNSLCSPSSVAVIEAKKKNNV----------ALVGV 349
Query: 358 LAHEIGHNLGMHHDGTGNTCARDGYIMSPSRGTNGEASWS-SCSA 401
++HE+GH LGM C +M+ + +S SC A
Sbjct: 350 MSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRA 394
>BC069582-1|AAH69582.1| 470|Homo sapiens ADAM-like, decysin 1
protein.
Length = 470
Score = 35.9 bits (79), Expect = 0.43
Identities = 72/345 (20%), Positives = 125/345 (36%), Gaps = 41/345 (11%)
Query: 64 GRNFDLQLVPNRRLVSPEFR--VWTERGEEKPLSSVDAS-CHF---LHASPNAVAAFSAC 117
G L L + L+ P++ +++ RGEE + C++ + N+VA+ S C
Sbjct: 84 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 143
Query: 118 KDHALHGLIVVDNSTYEVRPLPSGVGRAENSYGRTAHVIRRASPPSXXXXXXXXXXXXXX 177
L G + Y+++PL S + + A+
Sbjct: 144 D--GLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRI 201
Query: 178 XXXXXXXXXXKKGPASYTIEIALFLDEAAYKIFHPFFHYNEADLRDMLLAYINGVQALYQ 237
A I++ L LD A YK ++ N +R + +N + +Y
Sbjct: 202 SRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNE----NLTLIRSFVFDVMNLLNVIYN 257
Query: 238 HSSLGTHIQLSLVRLTLLRSQPTDLSAHAERGKLLDSFCAYQRSLNVEDDEDPEHWDMAL 297
+Q++LV + + S + D+F + S + + D A
Sbjct: 258 TID----VQVALVGMEIW-SDGDKIKVVPSASTTFDNFLRWHSS-----NLGKKIHDHAQ 307
Query: 298 LLSGLDFYSEENGRRNGVTMGLAPVGGVCLPAHACVVSEFGATDVLGRPYPSAGFTSVYI 357
LLSG+ F N RR +GLA +C P+ V+ +V V +
Sbjct: 308 LLSGISF----NNRR----VGLAASNSLCSPSSVAVIEAKKKNNV----------ALVGV 349
Query: 358 LAHEIGHNLGMHHDGTGNTCARDGYIMSPSRGTNGEASWS-SCSA 401
++HE+GH LGM C +M+ + +S SC A
Sbjct: 350 MSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRA 394
>AF141293-1|AAF02493.1| 518|Homo sapiens ADAMTS5 protein protein.
Length = 518
Score = 35.1 bits (77), Expect = 0.75
Identities = 51/197 (25%), Positives = 74/197 (37%), Gaps = 42/197 (21%)
Query: 363 GHNLGMHHDGT-------GNTCARDGYIMSPSRGTNGEAS--WSSCSARVVADLKWATCL 413
GH LG+ HD + G+T D +MS S T+ +AS WS C++ + +
Sbjct: 1 GHLLGLSHDDSKFCEETFGST--EDKRLMS-SILTSIDASKPWSKCTSATITEFL----- 52
Query: 414 LDGDDGEEDIPNELQHERFSGA---PGAIWSAKKQCEVLLR-DADAAPWSGGGDQRGQCA 469
DDG + +L ++ G PG + A +QC + + P G D CA
Sbjct: 53 ---DDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCP---GXDV---CA 103
Query: 470 QLACRTPHRAGFFYAG---PALPGTACGNKMWCQGGECXXXXXXXXXXXXXXXXAGMAEG 526
+L C + PA+ GT CG C G+C + G
Sbjct: 104 RLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTS-------SHG 156
Query: 527 ESGGWTVWREGACRSGC 543
G W W G C C
Sbjct: 157 NWGSWGSW--GQCSRSC 171
>BC025378-1|AAH25378.2| 776|Homo sapiens ADAM metallopeptidase
domain 20 protein.
Length = 776
Score = 34.7 bits (76), Expect = 0.99
Identities = 18/43 (41%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 358 LAHEIGHNLGMHHDGTGNTCARDGYIMSPSRGTNGEASWSSCS 400
L HE+GHNLGM HD C IM R +S+CS
Sbjct: 390 LGHELGHNLGMQHDTQWCVCELQWCIMHAYRKVT--TKFSNCS 430
>AF247668-1|AAK28400.1| 227|Homo sapiens a disintegrin-like and
metalloprotease domain with thrombospondin type I motifs
protein.
Length = 227
Score = 34.7 bits (76), Expect = 0.99
Identities = 16/37 (43%), Positives = 26/37 (70%)
Query: 44 QSSVDGSNDDVPLPYNFDAFGRNFDLQLVPNRRLVSP 80
+S+ D S++ L +N AFG++F L+L PN +LV+P
Sbjct: 68 RSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAP 104
>AF158643-1|AAD55254.1| 726|Homo sapiens
metalloproteinase-disintegrin protein.
Length = 726
Score = 34.7 bits (76), Expect = 0.99
Identities = 18/43 (41%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 358 LAHEIGHNLGMHHDGTGNTCARDGYIMSPSRGTNGEASWSSCS 400
L HE+GHNLGM HD C IM R +S+CS
Sbjct: 340 LGHELGHNLGMQHDTQWCVCELQWCIMHAYRKVT--TKFSNCS 380
>AF029899-1|AAC52041.1| 726|Homo sapiens ADAM 20 protein.
Length = 726
Score = 34.7 bits (76), Expect = 0.99
Identities = 18/43 (41%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 358 LAHEIGHNLGMHHDGTGNTCARDGYIMSPSRGTNGEASWSSCS 400
L HE+GHNLGM HD C IM R +S+CS
Sbjct: 340 LGHELGHNLGMQHDTQWCVCELQWCIMHAYRKVT--TKFSNCS 380
>AK096298-1|BAC04753.1| 262|Homo sapiens protein ( Homo sapiens
cDNA FLJ38979 fis, clone NT2RI2004608. ).
Length = 262
Score = 32.7 bits (71), Expect = 4.0
Identities = 14/31 (45%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 269 GKLLDSF-CAYQRSLNVEDDEDPEHWDMALL 298
GK L+ + AYQ N+++DED E W A+L
Sbjct: 196 GKALEVYTAAYQNIQNIDEDEDLERWSFAML 226
>BC109092-1|AAI09093.1| 664|Homo sapiens peptidyl arginine
deiminase, type III protein.
Length = 664
Score = 32.3 bits (70), Expect = 5.3
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDASCHFLHASPNAVA 112
LP FD+ RN +LQ P +R++ P+F T ++ +S +D S L SP VA
Sbjct: 364 LPVVFDS-PRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLD-SFGNLEVSPPVVA 418
>BC109091-1|AAI09092.1| 664|Homo sapiens peptidyl arginine
deiminase, type III protein.
Length = 664
Score = 32.3 bits (70), Expect = 5.3
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDASCHFLHASPNAVA 112
LP FD+ RN +LQ P +R++ P+F T ++ +S +D S L SP VA
Sbjct: 364 LPVVFDS-PRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLD-SFGNLEVSPPVVA 418
>BC041592-1|AAH41592.1| 664|Homo sapiens peptidyl arginine
deiminase, type III protein.
Length = 664
Score = 32.3 bits (70), Expect = 5.3
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDASCHFLHASPNAVA 112
LP FD+ RN +LQ P +R++ P+F T ++ +S +D S L SP VA
Sbjct: 364 LPVVFDS-PRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLD-SFGNLEVSPPVVA 418
>AL590644-2|CAH73166.1| 664|Homo sapiens peptidyl arginine
deiminase, type III protein.
Length = 664
Score = 32.3 bits (70), Expect = 5.3
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDASCHFLHASPNAVA 112
LP FD+ RN +LQ P +R++ P+F T ++ +S +D S L SP VA
Sbjct: 364 LPVVFDS-PRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLD-SFGNLEVSPPVVA 418
>AJ549502-4|CAE47742.1| 664|Homo sapiens peptidylarginine deiminase
type III protein.
Length = 664
Score = 32.3 bits (70), Expect = 5.3
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDASCHFLHASPNAVA 112
LP FD+ RN +LQ P +R++ P+F T ++ +S +D S L SP VA
Sbjct: 364 LPVVFDS-PRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLD-SFGNLEVSPPVVA 418
>AB026831-1|BAA85974.1| 664|Homo sapiens peptidylarginine deiminase
type III protein.
Length = 664
Score = 32.3 bits (70), Expect = 5.3
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 56 LPYNFDAFGRNFDLQLVPNRRLVSPEFRVWTERGEEKPLSSVDASCHFLHASPNAVA 112
LP FD+ RN +LQ P +R++ P+F T ++ +S +D S L SP VA
Sbjct: 364 LPVVFDS-PRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLD-SFGNLEVSPPVVA 418
>AP001697-2|BAA95503.1| 517|Homo sapiens disintegrin-like and
metalloprotease with thrombospondin type 1 motif, 5
protein.
Length = 517
Score = 31.9 bits (69), Expect = 7.0
Identities = 50/196 (25%), Positives = 73/196 (37%), Gaps = 42/196 (21%)
Query: 364 HNLGMHHDGT-------GNTCARDGYIMSPSRGTNGEAS--WSSCSARVVADLKWATCLL 414
H LG+ HD + G+T D +MS S T+ +AS WS C++ + +
Sbjct: 1 HLLGLSHDDSKFCEETFGST--EDKRLMS-SILTSIDASKPWSKCTSATITEFL------ 51
Query: 415 DGDDGEEDIPNELQHERFSGA---PGAIWSAKKQCEVLLR-DADAAPWSGGGDQRGQCAQ 470
DDG + +L ++ G PG + A +QC + + P G D CA+
Sbjct: 52 --DDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCP---GMDV---CAR 103
Query: 471 LACRTPHRAGFFYAG---PALPGTACGNKMWCQGGECXXXXXXXXXXXXXXXXAGMAEGE 527
L C + PA+ GT CG C G+C + G
Sbjct: 104 LWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTS-------SHGN 156
Query: 528 SGGWTVWREGACRSGC 543
G W W G C C
Sbjct: 157 WGSWGSW--GQCSRSC 170
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.135 0.429
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 94,870,346
Number of Sequences: 224733
Number of extensions: 4136000
Number of successful extensions: 11948
Number of sequences better than 10.0: 177
Number of HSP's better than 10.0 without gapping: 138
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 11388
Number of HSP's gapped (non-prelim): 313
length of query: 622
length of database: 73,234,838
effective HSP length: 94
effective length of query: 528
effective length of database: 52,109,936
effective search space: 27514046208
effective search space used: 27514046208
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 68 (31.5 bits)
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