Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002617-TA|BGIBMGA002617-PA|IPR001611|Leucine-rich
repeat, IPR003591|Leucine-rich repeat, typical subtype
(753 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AY313607-1|AAP79898.1| 613|Homo sapiens podocan protein protein. 111 7e-24
AL445183-5|CAH72592.1| 642|Homo sapiens podocan protein. 111 7e-24
AL445183-4|CAH72591.1| 661|Homo sapiens podocan protein. 111 7e-24
BC030608-1|AAH30608.1| 661|Homo sapiens podocan protein. 111 9e-24
AY358294-1|AAQ88661.1| 642|Homo sapiens EGEE293 protein. 111 9e-24
BC033039-1|AAH33039.1| 927|Homo sapiens LGR4 protein protein. 110 2e-23
AB209743-1|BAD92980.1| 1032|Homo sapiens Leucine-rich repeat-con... 106 3e-22
AF346711-1|AAK31153.1| 951|Homo sapiens G-protein couple recept... 103 2e-21
BC025681-1|AAH25681.1| 605|Homo sapiens insulin-like growth fac... 101 7e-21
M86826-1|AAA36047.1| 605|Homo sapiens insulin-like growth facto... 101 9e-21
AL031724-2|CAC36078.1| 605|Homo sapiens C447E6.2 (insulin-like ... 101 9e-21
AF192554-1|AAF06774.1| 605|Homo sapiens acid-labile subunit pro... 101 9e-21
AF381545-1|AAK62357.1| 1093|Homo sapiens membrane glycoprotein L... 100 2e-20
AB050468-1|BAB40659.1| 1094|Homo sapiens membrane glycoprotein L... 100 2e-20
AY730707-1|AAU44786.1| 1093|Homo sapiens leucine-rich repeat pro... 99 3e-20
BC129927-1|AAI29928.1| 1323|Homo sapiens PH domain and leucine r... 100 4e-20
BC096326-1|AAH96326.1| 883|Homo sapiens LGR5 protein protein. 99 5e-20
BC096325-1|AAH96325.1| 883|Homo sapiens LGR5 protein protein. 99 5e-20
BC035267-1|AAH35267.1| 723|Homo sapiens PHLPPL protein protein. 99 5e-20
AF257182-1|AAF68989.1| 951|Homo sapiens G-protein-coupled recep... 98 9e-20
Z24680-1|CAA80847.1| 662|Homo sapiens garp protein. 95 1e-18
BC070079-1|AAH70079.1| 662|Homo sapiens LRRC32 protein protein. 95 1e-18
BC036337-1|AAH36337.1| 811|Homo sapiens KIAA0644 gene product p... 94 2e-18
AB014544-1|BAA31619.2| 887|Homo sapiens KIAA0644 protein protein. 94 2e-18
BC101065-1|AAI01066.1| 581|Homo sapiens LRRC15 protein protein. 93 3e-18
BC101064-1|AAI01065.1| 581|Homo sapiens leucine rich repeat con... 93 3e-18
BC071561-1|AAH71561.1| 1070|Homo sapiens LRIG1 protein protein. 93 3e-18
AB071037-1|BAB84587.1| 581|Homo sapiens Lib protein. 92 8e-18
AY358733-1|AAQ89095.1| 622|Homo sapiens CGLQ1891 protein. 91 1e-17
AY280614-1|AAP36706.1| 622|Homo sapiens synleurin protein. 91 1e-17
AK123022-1|BAC85517.1| 622|Homo sapiens protein ( Homo sapiens ... 91 1e-17
BC057786-1|AAH57786.1| 512|Homo sapiens podocan-like 1 protein. 91 1e-17
BC113617-1|AAI13618.1| 757|Homo sapiens relaxin/insulin-like fa... 90 2e-17
BC112142-1|AAI12143.1| 757|Homo sapiens leucine-rich repeat-con... 90 2e-17
AY899850-1|AAX85198.1| 724|Homo sapiens LGR7.10 protein. 90 2e-17
AF190500-1|AAG17167.1| 757|Homo sapiens leucine-rich repeat-con... 90 2e-17
AB208943-1|BAD92180.1| 627|Homo sapiens leucine-rich repeat-con... 90 2e-17
AY358114-1|AAQ88481.1| 606|Homo sapiens Tango hlg protein. 89 4e-17
AL353746-1|CAC22713.1| 606|Homo sapiens leucine rich repeat neu... 89 4e-17
AK056372-1|BAB71167.1| 606|Homo sapiens protein ( Homo sapiens ... 89 4e-17
BC099650-1|AAH99650.1| 907|Homo sapiens leucine-rich repeat-con... 89 5e-17
BC096324-1|AAH96324.1| 907|Homo sapiens leucine-rich repeat-con... 89 5e-17
AF062006-1|AAC28019.1| 907|Homo sapiens orphan G protein-couple... 89 5e-17
BC126171-1|AAI26172.1| 1119|Homo sapiens leucine-rich repeats an... 89 7e-17
BC126169-1|AAI26170.1| 1119|Homo sapiens leucine-rich repeats an... 89 7e-17
AY505340-1|AAR98629.1| 1119|Homo sapiens leucine-rich and immuno... 89 7e-17
AY358295-1|AAQ88662.1| 1059|Homo sapiens SAPS287 protein. 89 7e-17
AY358288-1|AAQ88655.1| 1119|Homo sapiens SAPS287 protein. 89 7e-17
AL356953-1|CAI15927.1| 967|Homo sapiens leucine-rich repeat-con... 88 9e-17
BC094737-1|AAH94737.1| 904|Homo sapiens toll-like receptor 3 pr... 88 1e-16
U88879-1|AAC34134.1| 904|Homo sapiens Toll-like receptor 3 prot... 87 2e-16
DQ445682-1|ABE01399.1| 904|Homo sapiens Toll-like receptor 3 is... 87 2e-16
BC096335-1|AAH96335.1| 904|Homo sapiens toll-like receptor 3 pr... 87 2e-16
BC096334-1|AAH96334.1| 904|Homo sapiens toll-like receptor 3 pr... 87 2e-16
BC096333-1|AAH96333.1| 904|Homo sapiens toll-like receptor 3 pr... 87 2e-16
BC059372-1|AAH59372.1| 870|Homo sapiens TLR3 protein protein. 87 2e-16
BC034947-1|AAH34947.1| 716|Homo sapiens leucine rich repeat neu... 87 2e-16
AY358312-1|AAQ88679.1| 716|Homo sapiens NLRR protein. 86 4e-16
AF061444-1|AAC77911.1| 907|Homo sapiens G protein-coupled recep... 86 4e-16
AB074161-1|BAE45733.1| 716|Homo sapiens neuronal leucine-rich r... 86 4e-16
AB049405-1|BAB39854.1| 928|Homo sapiens VTS20631 protein. 86 4e-16
AB040930-1|BAA96021.1| 730|Homo sapiens KIAA1497 protein protein. 86 4e-16
BC047905-1|AAH47905.2| 915|Homo sapiens leucine-rich repeat-con... 86 5e-16
AY358119-1|AAQ88486.1| 915|Homo sapiens gonadotropin receptor p... 86 5e-16
AL356953-3|CAI15929.1| 915|Homo sapiens leucine-rich repeat-con... 86 5e-16
J05158-1|AAA51921.2| 545|Homo sapiens carboxypeptidase N precur... 83 3e-15
BC050445-1|AAH50445.1| 582|Homo sapiens soc-2 suppressor of cle... 83 3e-15
BC031569-1|AAH31569.2| 545|Homo sapiens carboxypeptidase N, pol... 83 3e-15
AL158163-2|CAH72812.1| 582|Homo sapiens soc-2 suppressor of cle... 83 3e-15
AF068920-1|AAC39856.1| 582|Homo sapiens Ras-binding protein SUR... 83 3e-15
AF054828-1|AAC25698.1| 582|Homo sapiens leucine-rich repeat pro... 83 3e-15
AB020669-1|BAA74885.2| 584|Homo sapiens KIAA0862 protein protein. 83 3e-15
BC042334-1|AAH42334.2| 545|Homo sapiens carboxypeptidase N, pol... 83 5e-15
BC018370-1|AAH18370.1| 674|Homo sapiens fibronectin leucine ric... 82 6e-15
BC008586-1|AAH08586.1| 602|Homo sapiens leucine rich repeat con... 82 6e-15
BC003407-1|AAH03407.2| 581|Homo sapiens LRRC40 protein protein. 82 6e-15
AY358308-1|AAQ88675.1| 674|Homo sapiens FLRT1 protein. 82 6e-15
AL353771-3|CAI22332.1| 602|Homo sapiens leucine rich repeat con... 82 6e-15
AK022951-1|BAB14326.1| 602|Homo sapiens protein ( Homo sapiens ... 82 6e-15
AF169675-1|AAF28459.1| 674|Homo sapiens leucine-rich repeat tra... 82 6e-15
BC035133-1|AAH35133.1| 708|Homo sapiens leucine rich repeat neu... 82 8e-15
CR457397-1|CAG33678.1| 708|Homo sapiens LRRN3 protein. 80 2e-14
AY358280-1|AAQ88647.1| 708|Homo sapiens LRRN3 protein. 80 2e-14
AF134481-1|AAP97258.1| 708|Homo sapiens leucine-rich repeat pro... 80 2e-14
AB060967-1|BAB47184.1| 708|Homo sapiens neuronal leucine-rich r... 80 2e-14
BC073974-1|AAH73974.1| 359|Homo sapiens chondroadherin protein. 79 4e-14
BC036360-1|AAH36360.1| 359|Homo sapiens chondroadherin protein. 79 4e-14
AF371328-1|AAK51556.1| 359|Homo sapiens chondroadherin protein. 79 4e-14
BC117370-1|AAI17371.1| 1065|Homo sapiens leucine-rich repeats an... 79 6e-14
BC117368-1|AAI17369.1| 1065|Homo sapiens leucine-rich repeats an... 79 6e-14
AL357055-1|CAH73254.1| 1065|Homo sapiens leucine-rich repeats an... 79 6e-14
AB018349-1|BAA34526.2| 1073|Homo sapiens KIAA0806 protein protein. 79 6e-14
BC033651-1|AAH33651.1| 1049|Homo sapiens toll-like receptor 7 pr... 78 1e-13
AY358292-1|AAQ88659.1| 1049|Homo sapiens TLR7 protein. 78 1e-13
AF245702-1|AAF78035.1| 1049|Homo sapiens toll-like receptor 7 pr... 78 1e-13
AF240467-1|AAF60188.1| 1049|Homo sapiens toll-like receptor 7 pr... 78 1e-13
AB023148-1|BAA76775.2| 1258|Homo sapiens KIAA0931 protein protein. 78 1e-13
Z23091-1|CAA80637.1| 560|Homo sapiens platelet glycoprotein V p... 78 1e-13
L11238-1|AAA03069.1| 560|Homo sapiens platelet membrane glycopr... 78 1e-13
BC028292-1|AAH28292.1| 402|Homo sapiens PODN protein protein. 78 1e-13
U96769-1|AAC13410.1| 359|Homo sapiens chondroadherin protein. 77 2e-13
BC113717-1|AAI13718.1| 581|Homo sapiens leucine rich repeat tra... 77 2e-13
BC113715-1|AAI13716.1| 581|Homo sapiens leucine rich repeat tra... 77 2e-13
BC111492-1|AAI11493.1| 581|Homo sapiens leucine rich repeat tra... 77 2e-13
BC068558-1|AAH68558.1| 614|Homo sapiens LINGO1 protein protein. 77 2e-13
AY358315-1|AAQ88681.1| 513|Homo sapiens GFNV803 protein. 77 2e-13
AY182028-1|AAO67549.1| 513|Homo sapiens leucine-rich repeat tra... 77 2e-13
BC126410-1|AAI26411.1| 516|Homo sapiens leucine rich repeat tra... 76 4e-13
BC126408-1|AAI26409.1| 516|Homo sapiens leucine rich repeat tra... 76 4e-13
AY182026-1|AAO67547.1| 516|Homo sapiens leucine-rich repeat tra... 76 4e-13
AB007876-1|BAA24846.2| 529|Homo sapiens KIAA0416 protein. 76 4e-13
BC011057-1|AAH11057.2| 620|Homo sapiens leucine rich repeat and... 75 9e-13
AY358284-1|AAQ88651.1| 620|Homo sapiens QVSK201 protein. 75 9e-13
AY324320-1|AAQ97216.1| 620|Homo sapiens leucine-rich repeat neu... 75 9e-13
AL834260-1|CAD38935.1| 577|Homo sapiens hypothetical protein pr... 75 9e-13
AB016816-1|BAA74737.1| 1052|Homo sapiens MASL1 protein. 75 9e-13
BC131897-1|AAI31898.1| 420|Homo sapiens LRRC4B protein protein. 75 1e-12
BC032460-1|AAH32460.1| 634|Homo sapiens Unknown (protein for IM... 75 1e-12
BC101077-1|AAI01078.1| 1041|Homo sapiens toll-like receptor 8 pr... 74 2e-12
BC101076-1|AAI01077.1| 1041|Homo sapiens toll-like receptor 8 pr... 74 2e-12
BC101075-1|AAI01076.1| 1041|Homo sapiens toll-like receptor 8 pr... 74 2e-12
BC101074-1|AAI01075.1| 1041|Homo sapiens toll-like receptor 8 pr... 74 2e-12
AF245703-1|AAF78036.1| 1041|Homo sapiens toll-like receptor 8 pr... 74 2e-12
DQ084201-1|AAY86708.1| 640|Homo sapiens netrin-G1 ligand splice... 73 3e-12
BC110058-1|AAI10059.1| 518|Homo sapiens leucine rich repeat tra... 73 3e-12
BC107493-1|AAI07494.1| 699|Homo sapiens extracellular matrix pr... 73 3e-12
BC099738-1|AAH99738.1| 518|Homo sapiens leucine rich repeat tra... 73 3e-12
BC098301-1|AAH98301.1| 519|Homo sapiens LRRTM4 protein protein. 73 3e-12
BC098267-1|AAH98267.1| 519|Homo sapiens LRRTM4 protein protein. 73 3e-12
BC041374-1|AAH41374.3| 640|Homo sapiens LRRC4C protein protein. 73 3e-12
AY358324-1|AAQ88690.1| 590|Homo sapiens GFHL3075 protein. 73 3e-12
AY358296-1|AAQ88663.1| 1041|Homo sapiens TLR8 protein. 73 3e-12
AY358293-1|AAQ88660.1| 640|Homo sapiens LNKM292 protein. 73 3e-12
AY182030-1|AAO67551.1| 518|Homo sapiens leucine-rich repeat tra... 73 3e-12
AL157827-4|CAI12589.1| 699|Homo sapiens extracellular matrix pr... 73 3e-12
AL137848-1|CAI16693.1| 699|Homo sapiens extracellular matrix pr... 73 3e-12
AK126961-1|BAC86764.1| 518|Homo sapiens protein ( Homo sapiens ... 73 3e-12
AB046800-1|BAB13406.1| 640|Homo sapiens KIAA1580 protein protein. 73 3e-12
AB011792-1|BAA33958.1| 699|Homo sapiens extracellular matrix pr... 73 3e-12
BX537976-1|CAD97940.1| 693|Homo sapiens hypothetical protein pr... 73 4e-12
U80184-1|AAC02796.1| 1269|Homo sapiens FLII protein. 73 5e-12
U01184-1|AAC03568.1| 1268|Homo sapiens flightless-I homolog prot... 73 5e-12
BC109118-1|AAI09119.1| 858|Homo sapiens TLR5 protein protein. 73 5e-12
BC032667-1|AAH32667.1| 352|Homo sapiens keratocan protein. 73 5e-12
BC025300-1|AAH25300.1| 1269|Homo sapiens flightless I homolog (D... 73 5e-12
AY250221-1|AAP82838.1| 420|Homo sapiens nogo receptor-like 3 pr... 73 5e-12
AL929091-1|CAM28378.1| 858|Homo sapiens toll-like receptor 5 pr... 73 5e-12
AF205403-1|AAF69126.1| 352|Homo sapiens keratocan protein. 73 5e-12
AF065988-1|AAC17741.1| 352|Homo sapiens keratocan protein. 73 5e-12
AF063301-1|AAC16390.1| 352|Homo sapiens keratan sulfate proteog... 73 5e-12
AB208864-1|BAD92101.1| 1101|Homo sapiens flightless I homolog va... 73 5e-12
AB060695-1|BAB43955.1| 858|Homo sapiens Toll-like receptor 5 pr... 73 5e-12
DQ084202-1|AAY86709.1| 640|Homo sapiens netrin-G1 ligand splice... 72 7e-12
BC117276-1|AAI17277.1| 420|Homo sapiens reticulon 4 receptor-li... 72 7e-12
BC113673-1|AAI13674.1| 420|Homo sapiens reticulon 4 receptor-li... 72 7e-12
AF532858-1|AAP21835.1| 420|Homo sapiens Nogo-66 receptor homolo... 72 7e-12
BC130290-1|AAI30291.1| 660|Homo sapiens fibronectin leucine ric... 72 9e-12
BC126249-1|AAI26250.1| 660|Homo sapiens fibronectin leucine ric... 72 9e-12
BC109119-1|AAI09120.1| 858|Homo sapiens TLR5 protein protein. 72 9e-12
BC020870-1|AAH20870.1| 649|Homo sapiens fibronectin leucine ric... 72 9e-12
AY358319-1|AAQ88685.1| 649|Homo sapiens FLRT3 protein. 72 9e-12
AY358287-1|AAQ88654.1| 660|Homo sapiens FLRT2 protein. 72 9e-12
AL132826-1|CAB86687.1| 649|Homo sapiens fibronectin leucine ric... 72 9e-12
AK074909-1|BAC11284.1| 649|Homo sapiens protein ( Homo sapiens ... 72 9e-12
AK074883-1|BAC11265.1| 627|Homo sapiens protein ( Homo sapiens ... 72 9e-12
AK027694-1|BAB55303.1| 623|Homo sapiens protein ( Homo sapiens ... 72 9e-12
AK027297-1|BAB55023.1| 649|Homo sapiens protein ( Homo sapiens ... 72 9e-12
AF246971-1|AAF64061.1| 1059|Homo sapiens Toll-like receptor 8 pr... 72 9e-12
AF169677-1|AAF28461.1| 649|Homo sapiens leucine-rich repeat tra... 72 9e-12
AF169676-1|AAF28460.1| 660|Homo sapiens leucine-rich repeat tra... 72 9e-12
AB040902-1|BAA95993.1| 662|Homo sapiens KIAA1469 protein protein. 72 9e-12
AB007865-1|BAA23701.2| 706|Homo sapiens KIAA0405 protein. 72 9e-12
AF051151-1|AAC34376.1| 858|Homo sapiens Toll/interleukin-1 rece... 71 1e-11
U93091-1|AAC80227.1| 839|Homo sapiens Toll protein homolog prot... 71 2e-11
U88880-1|AAC34135.1| 799|Homo sapiens Toll-like receptor 4 prot... 71 2e-11
BC117422-1|AAI17423.1| 839|Homo sapiens toll-like receptor 4 pr... 71 2e-11
BC105958-1|AAI05959.1| 677|Homo sapiens ECM2 protein protein. 71 2e-11
AY358884-1|AAQ89243.1| 1523|Homo sapiens SLIT3 protein. 71 2e-11
AL160272-2|CAH72619.1| 799|Homo sapiens toll-like receptor 4 pr... 71 2e-11
AL160272-1|CAH72618.1| 839|Homo sapiens toll-like receptor 4 pr... 71 2e-11
AF177765-1|AAF05316.1| 839|Homo sapiens toll-like receptor 4 pr... 71 2e-11
AF172171-1|AAF89753.1| 839|Homo sapiens toll-like receptor 4 pr... 71 2e-11
AB017169-1|BAA35186.1| 1523|Homo sapiens Slit-3 protein protein. 71 2e-11
AB011538-1|BAA32466.2| 1559|Homo sapiens MEGF5 protein. 71 2e-11
Z93015-1|CAI42364.1| 481|Homo sapiens nyctalopin protein. 71 2e-11
BC112242-1|AAI12243.1| 481|Homo sapiens nyctalopin protein. 71 2e-11
AJ278865-1|CAC19014.1| 481|Homo sapiens leucine-rich repeat pro... 71 2e-11
AF254868-1|AAG42685.1| 481|Homo sapiens nyctalopin protein. 71 2e-11
AC108017-1|AAY41039.1| 260|Homo sapiens unknown protein. 70 3e-11
D83597-1|BAA12019.1| 661|Homo sapiens RP105 protein. 70 3e-11
BC109070-1|AAI09071.1| 661|Homo sapiens CD180 molecule protein. 70 3e-11
BC109069-1|AAI09070.1| 661|Homo sapiens CD180 molecule protein. 70 3e-11
AF177766-1|AAF07823.1| 752|Homo sapiens human toll-like recepto... 70 3e-11
BC034389-1|AAH34389.1| 347|Homo sapiens leucine-rich alpha-2-gl... 69 5e-11
AB073607-1|BAD38644.1| 347|Homo sapiens leucine-rich alpha-2-gl... 69 5e-11
BC070198-1|AAH70198.1| 347|Homo sapiens leucine-rich alpha-2-gl... 69 6e-11
AY358115-1|AAQ88482.1| 593|Homo sapiens DAAT9248 protein. 69 6e-11
AL589765-16|CAI17178.1| 593|Homo sapiens leucine rich repeat ne... 69 6e-11
AL356953-5|CAI15931.1| 232|Homo sapiens leucine-rich repeat-con... 69 6e-11
AF403428-1|AAK95527.1| 347|Homo sapiens leucine-rich alpha-2-gl... 69 6e-11
D63481-1|BAA09768.3| 1630|Homo sapiens KIAA0147 protein protein. 69 8e-11
BC052210-1|AAH52210.2| 552|Homo sapiens LRRC32 protein protein. 69 8e-11
AY062238-1|AAL38976.1| 1630|Homo sapiens scribble protein. 69 8e-11
AL159161-1|CAI17102.1| 754|Homo sapiens relaxin/insulin-like fa... 69 8e-11
AL138708-1|CAH73785.1| 754|Homo sapiens relaxin/insulin-like fa... 69 8e-11
AF453828-1|AAL73946.1| 754|Homo sapiens G protein-coupled recep... 69 8e-11
AF403384-1|AAL69324.2| 754|Homo sapiens LGR8 protein. 69 8e-11
AF240677-1|AAP88017.1| 1630|Homo sapiens CRIB1 protein. 69 8e-11
AY899849-1|AAX85197.1| 709|Homo sapiens LGR7.2 protein. 68 1e-10
AY899851-1|AAX85199.1| 730|Homo sapiens LGR8.1 protein. 68 1e-10
AL356953-4|CAI15930.1| 828|Homo sapiens leucine-rich repeat-con... 68 1e-10
AF271734-1|AAP88018.1| 1601|Homo sapiens SCRIB1 variant N1 protein. 68 1e-10
AF190501-1|AAG17168.1| 828|Homo sapiens leucine-rich repeat-con... 68 1e-10
BC111745-1|AAI11746.1| 653|Homo sapiens leucine rich repeat con... 67 2e-10
BC111561-1|AAI11562.1| 653|Homo sapiens leucine rich repeat con... 67 2e-10
BC045113-1|AAH45113.1| 522|Homo sapiens LRRTM1 protein protein. 67 2e-10
AY358310-1|AAQ88677.1| 522|Homo sapiens DFLL675 protein. 67 2e-10
AY358307-1|AAQ88674.1| 653|Homo sapiens NAG14 protein. 67 2e-10
AK172751-1|BAD18737.1| 653|Homo sapiens protein ( Homo sapiens ... 67 2e-10
AF196976-1|AAG28019.2| 653|Homo sapiens brain tumor associated ... 67 2e-10
AY182024-1|AAO67545.1| 522|Homo sapiens leucine-rich repeat tra... 67 2e-10
AK056644-1|BAB71240.1| 522|Homo sapiens protein ( Homo sapiens ... 67 2e-10
BC022500-1|AAH22500.1| 557|Homo sapiens leucine-rich, glioma in... 66 3e-10
AY358885-1|AAQ89244.1| 557|Homo sapiens LGI1 protein. 66 3e-10
AY358290-1|AAQ88657.1| 713|Homo sapiens GAC1 protein. 66 3e-10
AL512306-1|CAI14096.1| 713|Homo sapiens leucine rich repeat neu... 66 3e-10
AL358154-2|CAI14982.1| 557|Homo sapiens leucine-rich, glioma in... 66 3e-10
AL358154-1|CAI14981.1| 291|Homo sapiens leucine-rich, glioma in... 66 3e-10
AL157396-3|CAH73838.1| 557|Homo sapiens leucine-rich, glioma in... 66 3e-10
AL157396-2|CAH73837.1| 291|Homo sapiens leucine-rich, glioma in... 66 3e-10
AF473548-1|AAM22074.1| 291|Homo sapiens leucine-rich glioma ina... 66 3e-10
AF055636-1|AAC99316.1| 557|Homo sapiens leucine-rich glioma-ina... 66 3e-10
AF030435-1|AAC39792.1| 713|Homo sapiens glioma amplified on chr... 66 3e-10
AB011537-1|BAA32465.3| 1618|Homo sapiens MEGF4 protein. 66 3e-10
BC068541-1|AAH68541.1| 713|Homo sapiens leucine rich repeat neu... 66 4e-10
BC034047-1|AAH34047.1| 713|Homo sapiens leucine rich repeat neu... 66 4e-10
AJ297858-1|CAC82651.1| 649|Homo sapiens hypothetical protein pr... 66 4e-10
BC044233-1|AAH44233.1| 692|Homo sapiens leucine rich repeat con... 65 8e-10
BC003193-1|AAH03193.1| 524|Homo sapiens leucine rich repeat con... 65 8e-10
AY358322-1|AAQ88688.1| 692|Homo sapiens ELLP3030 protein. 65 8e-10
AL513211-1|CAI17358.1| 524|Homo sapiens leucine rich repeat con... 65 8e-10
AL033384-1|CAI21666.1| 524|Homo sapiens leucine rich repeat con... 65 8e-10
AF359380-1|AAK72246.1| 524|Homo sapiens LANO adaptor protein pr... 65 8e-10
AF332199-1|AAK69623.1| 524|Homo sapiens leucine-rich repeats pr... 65 8e-10
BC101761-1|AAI01762.1| 545|Homo sapiens leucine-rich repeat LGI... 65 1e-09
BC101759-1|AAI01760.1| 545|Homo sapiens leucine-rich repeat LGI... 65 1e-09
AY029183-1|AAK31796.1| 798|Homo sapiens SLIT1 isoform B protein. 65 1e-09
AL512424-5|CAI14258.1| 1534|Homo sapiens slit homolog 1 (Drosoph... 65 1e-09
AL512424-4|CAI14259.1| 1461|Homo sapiens slit homolog 1 (Drosoph... 65 1e-09
AL512424-3|CAI14257.1| 409|Homo sapiens slit homolog 1 (Drosoph... 65 1e-09
AL512424-1|CAI14255.1| 782|Homo sapiens slit homolog 1 (Drosoph... 65 1e-09
AL442123-4|CAH70917.1| 1461|Homo sapiens slit homolog 1 (Drosoph... 65 1e-09
AL442123-3|CAH70918.1| 1534|Homo sapiens slit homolog 1 (Drosoph... 65 1e-09
AJ487958-1|CAD32305.1| 545|Homo sapiens LGI1-like protein 2 pro... 65 1e-09
AJ487516-1|CAD31784.1| 545|Homo sapiens leucine-rich glioma ina... 65 1e-09
AF467955-1|AAM49553.1| 545|Homo sapiens LGI2 protein. 65 1e-09
AB067503-1|BAB67809.1| 542|Homo sapiens KIAA1916 protein protein. 65 1e-09
X75546-1|CAA53233.1| 376|Homo sapiens fibromodulin protein. 64 1e-09
U41344-1|AAC18782.1| 382|Homo sapiens prolargin protein. 64 2e-09
U29089-1|AAC50230.1| 382|Homo sapiens proline- arginine-rich en... 64 2e-09
CR542270-1|CAG47066.1| 382|Homo sapiens PRELP protein. 64 2e-09
BC117190-1|AAI17191.1| 1529|Homo sapiens slit homolog 2 (Drosoph... 64 2e-09
BC032498-1|AAH32498.1| 382|Homo sapiens proline/arginine-rich e... 64 2e-09
AY358116-1|AAQ88483.1| 548|Homo sapiens LGI3 protein. 64 2e-09
AL391817-1|CAI17033.1| 382|Homo sapiens proline/arginine-rich e... 64 2e-09
AJ487961-1|CAD32308.1| 548|Homo sapiens LGI1-like protein 4 pro... 64 2e-09
AJ487518-1|CAD31786.1| 548|Homo sapiens leucine-rich glioma ina... 64 2e-09
AF467956-1|AAM49554.1| 548|Homo sapiens LGI3 protein. 64 2e-09
AF133270-1|AAD25539.1| 1525|Homo sapiens SLIT2 protein. 64 2e-09
AF055585-1|AAD04309.1| 1521|Homo sapiens neurogenic extracellula... 64 2e-09
AB017168-1|BAA35185.1| 1529|Homo sapiens Slit-2 protein protein. 64 2e-09
AB017167-1|BAA35184.1| 1534|Homo sapiens Slit-1 protein protein. 64 2e-09
BC063114-1|AAH63114.1| 384|Homo sapiens ASPN protein protein. 64 2e-09
BC035281-1|AAH35281.1| 376|Homo sapiens fibromodulin protein. 64 2e-09
AY358329-1|AAQ88695.1| 379|Homo sapiens ASPN protein. 64 2e-09
AY029191-1|AAK31800.1| 381|Homo sapiens periodontal ligament as... 64 2e-09
AL359837-1|CAH73821.1| 376|Homo sapiens fibromodulin protein. 64 2e-09
AL137848-5|CAI16697.1| 380|Homo sapiens asporin (LRR class 1) p... 64 2e-09
AF316824-1|AAK35161.1| 379|Homo sapiens asporin precursor protein. 64 2e-09
CR541787-1|CAG46586.1| 382|Homo sapiens PRELP protein. 63 3e-09
AY324323-1|AAQ97218.1| 479|Homo sapiens leucine-rich repeat neu... 63 3e-09
AK223177-1|BAD96897.1| 338|Homo sapiens lumican variant protein. 63 3e-09
X57436-1|CAA40684.1| 440|Homo sapiens oligodentrocyte-myelin gl... 63 4e-09
U21128-1|AAA91639.1| 338|Homo sapiens lumican protein. 63 4e-09
U18728-1|AAA85268.1| 338|Homo sapiens lumican protein. 63 4e-09
CR456360-1|CAG30246.1| 473|Homo sapiens Em:AC007663.1 protein. 63 4e-09
BT006707-1|AAP35353.1| 338|Homo sapiens lumican protein. 63 4e-09
BC058935-1|AAH58935.1| 239|Homo sapiens LRRC57 protein protein. 63 4e-09
BC035997-1|AAH35997.1| 338|Homo sapiens lumican protein. 63 4e-09
BC018050-1|AAH18050.1| 440|Homo sapiens oligodendrocyte myelin ... 63 4e-09
BC014904-1|AAH14904.1| 893|Homo sapiens leucine-rich repeats an... 63 4e-09
BC011787-1|AAH11787.1| 473|Homo sapiens reticulon 4 receptor pr... 63 4e-09
BC007038-1|AAH07038.1| 338|Homo sapiens lumican protein. 63 4e-09
AY358297-1|AAQ88664.1| 473|Homo sapiens NOGOR protein. 63 4e-09
AK222663-1|BAD96383.1| 440|Homo sapiens oligodendrocyte myelin ... 63 4e-09
AK094891-1|BAC04451.1| 239|Homo sapiens protein ( Homo sapiens ... 63 4e-09
AK094131-1|BAC04294.1| 239|Homo sapiens (EC 2.4.1.101). protein. 63 4e-09
AF283463-1|AAG53612.1| 473|Homo sapiens Nogo receptor protein. 63 4e-09
AF274972-1|AAG13461.1| 910|Homo sapiens PIDD protein. 63 4e-09
BC043165-1|AAH43165.1| 719|Homo sapiens leucine rich repeat and... 62 5e-09
AY359085-1|AAQ89443.1| 1032|Homo sapiens TLR9 protein. 62 5e-09
AK127591-1|BAC87047.1| 341|Homo sapiens protein ( Homo sapiens ... 62 5e-09
AK055365-1|BAB70910.1| 719|Homo sapiens protein ( Homo sapiens ... 62 5e-09
X72913-1|CAA51418.1| 376|Homo sapiens fibromodulin protein. 62 7e-09
X51694-1|CAA35991.1| 433|Homo sapiens oligodendrocyte-myelin gl... 62 7e-09
M63623-1|AAA59970.1| 440|Homo sapiens oligodendrocyte-myelin gl... 62 7e-09
AL391728-2|CAH73692.1| 1495|Homo sapiens leucine rich repeat con... 62 7e-09
AL391728-1|CAH73691.1| 1537|Homo sapiens leucine rich repeat con... 62 7e-09
AL359412-2|CAH74019.1| 1495|Homo sapiens leucine rich repeat con... 62 7e-09
AL359412-1|CAH74018.1| 1537|Homo sapiens leucine rich repeat con... 62 7e-09
AL158840-2|CAH70975.1| 1495|Homo sapiens leucine rich repeat con... 62 7e-09
AL158840-1|CAH70974.1| 1537|Homo sapiens leucine rich repeat con... 62 7e-09
AL157948-2|CAI22426.1| 1495|Homo sapiens leucine rich repeat con... 62 7e-09
AL157948-1|CAI22425.1| 1537|Homo sapiens leucine rich repeat con... 62 7e-09
AL117353-1|CAI23423.1| 1495|Homo sapiens leucine rich repeat con... 62 7e-09
AK021896-1|BAB13929.1| 197|Homo sapiens protein ( Homo sapiens ... 62 7e-09
AF434715-1|AAL28133.1| 1537|Homo sapiens densin-180 protein. 62 7e-09
AF245704-1|AAF78037.1| 1032|Homo sapiens toll-like receptor 9 pr... 62 7e-09
BC109112-1|AAI09113.1| 811|Homo sapiens TLR10 protein protein. 62 9e-09
BC109111-1|AAI09112.1| 811|Homo sapiens TLR10 protein protein. 62 9e-09
BC089406-1|AAH89406.1| 811|Homo sapiens TLR10 protein protein. 62 9e-09
AY358300-1|AAQ88667.1| 811|Homo sapiens TLR10 protein. 62 9e-09
AF296673-1|AAK26744.1| 811|Homo sapiens toll-like receptor 10 p... 62 9e-09
AB020807-1|BAA78631.1| 796|Homo sapiens TLR6 protein. 62 9e-09
BC071866-1|AAH71866.1| 460|Homo sapiens Unknown (protein for IM... 61 1e-08
BC032713-1|AAH32713.1| 1032|Homo sapiens toll-like receptor 9 pr... 61 1e-08
BC015581-1|AAH15581.2| 635|Homo sapiens leucine rich repeat and... 61 1e-08
BC007718-1|AAH07718.1| 541|Homo sapiens LRFN4 protein protein. 61 1e-08
AF259263-1|AAF72190.1| 975|Homo sapiens toll-like receptor 9 fo... 61 1e-08
AF259262-1|AAF72189.1| 1032|Homo sapiens toll-like receptor 9 fo... 61 1e-08
AB209005-1|BAD92242.1| 622|Homo sapiens leucine rich repeat and... 61 1e-08
AB045180-1|BAB19259.1| 1032|Homo sapiens toll-like receptor 9 pr... 61 1e-08
BC111755-1|AAI11756.1| 480|Homo sapiens TLR6 protein protein. 60 2e-08
D86983-1|BAA13219.1| 1496|Homo sapiens KIAA0230 protein. 60 3e-08
D13637-1|BAA02801.2| 789|Homo sapiens KIAA0012 protein. 60 3e-08
BC098579-1|AAH98579.1| 722|Homo sapiens PXDN protein protein. 60 3e-08
BC068590-1|AAH68590.1| 778|Homo sapiens LOC150356 protein protein. 60 3e-08
AL035681-1|CAI22653.1| 762|Homo sapiens protein ( Human DNA seq... 60 3e-08
AF200348-1|AAF06354.1| 1496|Homo sapiens melanoma-associated ant... 60 3e-08
U88540-1|AAC34137.1| 786|Homo sapiens Toll-like receptor 1 prot... 60 4e-08
BC109094-1|AAI09095.1| 786|Homo sapiens toll-like receptor 1 pr... 60 4e-08
BC109093-1|AAI09094.1| 786|Homo sapiens toll-like receptor 1 pr... 60 4e-08
BC089403-1|AAH89403.1| 786|Homo sapiens toll-like receptor 1 pr... 60 4e-08
BC080586-1|AAH80586.1| 743|Homo sapiens MXRA5 protein protein. 60 4e-08
BC064986-1|AAH64986.1| 743|Homo sapiens MXRA5 protein protein. 60 4e-08
BC040188-1|AAH40188.1| 692|Homo sapiens LOC150356 protein protein. 60 4e-08
BC011846-1|AAH11846.1| 743|Homo sapiens MXRA5 protein protein. 60 4e-08
AF245505-1|AAF86402.1| 2828|Homo sapiens adlican protein. 60 4e-08
Y19205-1|CAC80724.1| 845|Homo sapiens SLITL1 protein. 59 5e-08
BC126277-1|AAI26278.1| 1205|Homo sapiens PH domain and leucine r... 59 5e-08
BC113012-1|AAI13013.1| 845|Homo sapiens SLIT and NTRK-like fami... 59 5e-08
BC113011-1|AAI13012.1| 845|Homo sapiens SLIT and NTRK-like fami... 59 5e-08
BC103509-1|AAI03510.1| 958|Homo sapiens SLIT and NTRK-like fami... 59 5e-08
BC098287-1|AAH98287.1| 958|Homo sapiens SLIT and NTRK-like fami... 59 5e-08
BC098106-1|AAH98106.1| 958|Homo sapiens SLIT and NTRK-like fami... 59 5e-08
BC082244-1|AAH82244.1| 465|Homo sapiens PHLPP protein protein. 59 5e-08
BC014927-1|AAH14927.3| 1205|Homo sapiens PH domain and leucine r... 59 5e-08
AY358828-1|AAQ89187.1| 733|Homo sapiens LSGV9197 protein. 59 5e-08
AL603883-1|CAH73026.1| 958|Homo sapiens SLIT and NTRK-like fami... 59 5e-08
AL109653-2|CAC18888.1| 845|Homo sapiens SLIT and NTRK-like fami... 59 5e-08
AL109653-1|CAI41645.1| 724|Homo sapiens SLIT and NTRK-like fami... 59 5e-08
AK095610-1|BAC04589.1| 370|Homo sapiens protein ( Homo sapiens ... 59 5e-08
AK091015-1|BAC03566.1| 724|Homo sapiens protein ( Homo sapiens ... 59 5e-08
AK001924-1|BAA91980.1| 721|Homo sapiens protein ( Homo sapiens ... 59 5e-08
AB058757-1|BAB47483.1| 572|Homo sapiens KIAA1854 protein protein. 59 5e-08
AB020725-1|BAA74941.1| 966|Homo sapiens KIAA0918 protein protein. 59 5e-08
BC068575-1|AAH68575.1| 673|Homo sapiens vasorin protein. 59 7e-08
BC046356-1|AAH46356.1| 421|Homo sapiens osteomodulin protein. 59 7e-08
BC040986-1|AAH40986.1| 837|Homo sapiens SLIT and NTRK-like fami... 59 7e-08
BC013767-1|AAH13767.1| 601|Homo sapiens VASN protein protein. 59 7e-08
AY358872-1|AAQ89231.1| 421|Homo sapiens OMD protein. 59 7e-08
AY358299-1|AAQ88666.1| 673|Homo sapiens CSRV314 protein. 59 7e-08
AY324322-1|AAQ97217.1| 469|Homo sapiens leucine-rich repeat neu... 59 7e-08
AY166584-1|AAO27704.1| 673|Homo sapiens vasorin protein. 59 7e-08
AL137848-4|CAI16696.1| 421|Homo sapiens osteomodulin protein. 59 7e-08
AL080239-3|CAI41650.1| 837|Homo sapiens novel protein protein. 59 7e-08
AB009589-1|BAA23982.1| 421|Homo sapiens Osteomodulin protein. 59 7e-08
AB000114-1|BAA19055.1| 421|Homo sapiens osteomodulin protein. 59 7e-08
Z94160-2|CAI22122.1| 820|Homo sapiens protein ( Human DNA seque... 58 9e-08
BT007440-1|AAP36108.1| 353|Homo sapiens hypothetical protein, e... 58 9e-08
BC074741-1|AAH74741.1| 345|Homo sapiens leucine-rich repeats an... 58 9e-08
BC020975-1|AAH20975.1| 353|Homo sapiens tsukushin protein. 58 9e-08
AY358317-1|AAQ88683.1| 353|Homo sapiens E2IG4 protein. 58 9e-08
AY358127-1|AAQ88494.1| 627|Homo sapiens AILP5865 protein. 58 9e-08
AL591063-1|CAI15264.1| 789|Homo sapiens RP11-535K1.2 protein. 58 9e-08
AF225421-1|AAG09723.1| 345|Homo sapiens HT017 protein. 58 9e-08
AF191019-1|AAF09483.1| 353|Homo sapiens E2IG4 protein. 58 9e-08
AB067491-1|BAB67797.1| 821|Homo sapiens KIAA1904 protein protein. 58 9e-08
AB033072-1|BAA86560.1| 832|Homo sapiens KIAA1246 protein protein. 58 9e-08
AB011178-1|BAA25532.2| 1369|Homo sapiens KIAA0606 protein protein. 58 9e-08
U88878-1|AAC34133.1| 784|Homo sapiens Toll-like receptor 2 prot... 58 1e-07
BC040879-1|AAH40879.1| 493|Homo sapiens adhesion molecule with ... 58 1e-07
BC033756-1|AAH33756.1| 784|Homo sapiens TLR2 protein protein. 58 1e-07
BC030958-1|AAH30958.1| 322|Homo sapiens epiphycan protein. 58 1e-07
AY237007-1|AAO48948.1| 493|Homo sapiens transmembrane protein A... 58 1e-07
AY181242-1|AAO27354.1| 1331|Homo sapiens G protein-coupled recep... 58 1e-07
AY090637-1|AAM09084.1| 320|Homo sapiens tumor endothelial marke... 58 1e-07
AL355145-6|CAI22942.1| 493|Homo sapiens adhesion molecule with ... 58 1e-07
AK074099-1|BAB84925.1| 1310|Homo sapiens FLJ00170 protein protein. 58 1e-07
AF378755-1|AAL11992.1| 1331|Homo sapiens tumor endothelial marke... 58 1e-07
AF051152-1|AAC34377.1| 784|Homo sapiens Toll/interleukin-1 rece... 58 1e-07
AB040964-1|BAA96055.2| 1206|Homo sapiens KIAA1531 protein protein. 58 1e-07
AB032989-1|BAA86477.1| 437|Homo sapiens KIAA1163 protein protein. 58 1e-07
M14219-1|AAB00774.1| 359|Homo sapiens proteoglycan core protein... 58 2e-07
L01131-1|AAA52301.1| 347|Homo sapiens decorin protein. 58 2e-07
CR541946-1|CAG46744.1| 359|Homo sapiens DCN protein. 58 2e-07
CR407676-1|CAG28604.1| 359|Homo sapiens DCN protein. 58 2e-07
BT019800-1|AAV38603.1| 359|Homo sapiens decorin protein. 58 2e-07
BC005322-1|AAH05322.1| 359|Homo sapiens decorin protein. 58 2e-07
AF491944-1|AAL92176.1| 359|Homo sapiens decorin protein. 58 2e-07
AF138300-1|AAD44713.1| 359|Homo sapiens decorin variant A protein. 58 2e-07
AF075240-1|AAD19336.1| 850|Homo sapiens SLIT1 protein protein. 57 2e-07
CR533562-1|CAG38593.1| 786|Homo sapiens TLR1 protein. 57 3e-07
BC003578-1|AAH03578.1| 628|Homo sapiens leucine rich repeat and... 57 3e-07
AK172754-1|BAD18740.1| 628|Homo sapiens protein ( Homo sapiens ... 57 3e-07
U59111-1|AAC50945.1| 322|Homo sapiens dermatan sulfate proteogl... 56 3e-07
DQ355157-1|ABC79623.1| 334|Homo sapiens cytokeratin associated ... 56 3e-07
AL929554-11|CAH72880.1| 334|Homo sapiens leucine rich repeat co... 56 3e-07
AK001637-1|BAA91801.1| 183|Homo sapiens protein ( Homo sapiens ... 56 3e-07
BC126464-1|AAI26465.1| 1371|Homo sapiens erbb2 interacting prote... 56 5e-07
BC117180-1|AAI17181.1| 2527|Homo sapiens leucine-rich repeat kin... 56 5e-07
BC114551-1|AAI14552.1| 334|Homo sapiens ISLR2 protein protein. 56 5e-07
BC048421-1|AAH48421.1| 453|Homo sapiens LOC150356 protein protein. 56 5e-07
AY792511-1|AAV63975.1| 2527|Homo sapiens leucine-rich repeat kin... 56 5e-07
BC111013-1|AAI11014.1| 428|Homo sapiens immunoglobulin superfam... 56 6e-07
BC022478-1|AAH22478.1| 428|Homo sapiens immunoglobulin superfam... 56 6e-07
AY358871-1|AAQ89230.1| 428|Homo sapiens ISLR protein. 56 6e-07
AY358316-1|AAQ88682.1| 745|Homo sapiens FPLR1885 protein. 56 6e-07
AL512424-2|CAI14256.1| 380|Homo sapiens slit homolog 1 (Drosoph... 56 6e-07
AL158163-3|CAH72813.1| 372|Homo sapiens soc-2 suppressor of cle... 56 6e-07
AK223267-1|BAD96987.1| 428|Homo sapiens immunoglobulin superfam... 56 6e-07
AB040898-1|BAA95989.2| 785|Homo sapiens KIAA1465 protein protein. 56 6e-07
AB024537-1|BAA85971.1| 428|Homo sapiens ISLR protein. 56 6e-07
AB024536-1|BAA85970.1| 428|Homo sapiens ISLR protein. 56 6e-07
AB003184-1|BAA22848.1| 428|Homo sapiens ISLR protein. 56 6e-07
BC115015-1|AAI15016.1| 1367|Homo sapiens ERBB2IP protein protein. 55 8e-07
BC050692-1|AAH50692.1| 633|Homo sapiens ERBB2IP protein protein. 55 8e-07
AF502291-1|AAM23001.1| 586|Homo sapiens toll-like receptor 2 pr... 55 8e-07
AF276423-1|AAK69431.1| 1412|Homo sapiens densin-180-like protein... 55 8e-07
AF263744-1|AAF77048.1| 1371|Homo sapiens erbb2-interacting prote... 55 8e-07
AB033051-1|BAA86539.2| 1371|Homo sapiens KIAA1225 protein protein. 55 8e-07
BC115012-1|AAI15013.1| 1371|Homo sapiens erbb2 interacting prote... 55 1e-06
AY877349-1|AAX70929.1| 1463|Homo sapiens cardiac peroxidase prot... 55 1e-06
AK172834-1|BAD18799.1| 459|Homo sapiens protein ( Homo sapiens ... 55 1e-06
Z50749-1|CAA90626.1| 360|Homo sapiens yeast sds22 homolog protein. 54 1e-06
Z29083-1|CAA82324.1| 420|Homo sapiens 5T4 oncofoetal antigen pr... 54 1e-06
U32907-1|AAB41565.1| 313|Homo sapiens p37NB protein. 54 1e-06
BT020134-1|AAV38936.1| 360|Homo sapiens protein phosphatase 1, ... 54 1e-06
BC114621-1|AAI14622.1| 977|Homo sapiens SLIT and NTRK-like fami... 54 1e-06
BC037161-1|AAH37161.1| 420|Homo sapiens trophoblast glycoprotei... 54 1e-06
BC027903-1|AAH27903.1| 441|Homo sapiens leucine rich repeat con... 54 1e-06
BC000910-1|AAH00910.1| 360|Homo sapiens protein phosphatase 1, ... 54 1e-06
AY358889-1|AAQ89248.1| 440|Homo sapiens p37NB protein. 54 1e-06
AL121977-2|CAI21546.1| 420|Homo sapiens trophoblast glycoprotei... 54 1e-06
AJ012159-1|CAA09930.1| 420|Homo sapiens 5T4 oncofetal trophobla... 54 1e-06
AF067136-2|AAD26610.1| 317|Homo sapiens protein phosphatase-1 r... 54 1e-06
AF067136-1|AAD26611.1| 360|Homo sapiens protein phosphatase-1 r... 54 1e-06
AC073127-2|AAS07483.1| 313|Homo sapiens unknown protein. 54 1e-06
AB020655-1|BAA74871.2| 988|Homo sapiens KIAA0848 protein protein. 54 1e-06
D86984-1|BAA13220.2| 823|Homo sapiens KIAA0231 protein protein. 54 2e-06
BC095477-1|AAH95477.1| 522|Homo sapiens AMIGO2 protein protein. 54 2e-06
BC087848-1|AAH87848.1| 261|Homo sapiens LGI4 protein protein. 54 2e-06
BC060782-1|AAH60782.1| 803|Homo sapiens LRRC8B protein protein. 54 2e-06
BC047595-1|AAH47595.1| 522|Homo sapiens adhesion molecule with ... 54 2e-06
BC035645-1|AAH35645.1| 1266|Homo sapiens Similar to RIKEN cDNA 3... 54 2e-06
BC030607-1|AAH30607.1| 803|Homo sapiens leucine rich repeat con... 54 2e-06
BC027475-1|AAH27475.2| 528|Homo sapiens LRFN4 protein protein. 54 2e-06
AY454159-1|AAR83271.1| 522|Homo sapiens DEGA/AMIGO-2 precursor ... 54 2e-06
AY358306-1|AAQ88673.1| 616|Homo sapiens GPR125 protein. 54 2e-06
AY358121-1|AAQ88488.1| 261|Homo sapiens LGI4 protein. 54 2e-06
AY237005-1|AAO48946.1| 522|Homo sapiens transmembrane protein A... 54 2e-06
AJ487959-1|CAD32306.1| 537|Homo sapiens LGI1-like protein 3 pro... 54 2e-06
AJ487519-1|CAD31787.1| 537|Homo sapiens leucine-rich glioma ina... 54 2e-06
AF467954-1|AAM49552.1| 537|Homo sapiens LGI4 protein. 54 2e-06
AF385436-1|AAM43837.1| 803|Homo sapiens T-cell activation leuci... 54 2e-06
AB080610-1|BAC81189.1| 522|Homo sapiens alivin 1 protein. 54 2e-06
J04599-1|AAA36009.1| 368|Homo sapiens protein ( Human hPGI mRNA... 54 2e-06
BT007323-1|AAP35987.1| 368|Homo sapiens biglycan protein. 54 2e-06
BT007296-1|AAP35960.1| 280|Homo sapiens protein phosphatase 1, ... 54 2e-06
BC013001-1|AAH13001.1| 280|Homo sapiens PPP1R7 protein protein. 54 2e-06
BC012397-1|AAH12397.1| 280|Homo sapiens PPP1R7 protein protein. 54 2e-06
BC004244-1|AAH04244.1| 368|Homo sapiens biglycan protein. 54 2e-06
BC002416-1|AAH02416.1| 368|Homo sapiens biglycan protein. 54 2e-06
AY273815-1|AAQ16156.1| 2623|Homo sapiens bone specific CMF608 pr... 54 2e-06
AK223302-1|BAD97022.1| 368|Homo sapiens biglycan preproprotein ... 54 2e-06
AF067134-2|AAD26613.1| 237|Homo sapiens protein phosphatase-1 r... 54 2e-06
AF067134-1|AAD26612.1| 280|Homo sapiens protein phosphatase-1 r... 54 2e-06
BC051738-1|AAH51738.1| 696|Homo sapiens SLIT and NTRK-like fami... 53 3e-06
AY358289-1|AAQ88656.1| 696|Homo sapiens LLWI233 protein. 53 3e-06
AL355481-1|CAC37488.1| 696|Homo sapiens SLIT and NTRK-like fami... 53 3e-06
AK027296-1|BAB55022.1| 185|Homo sapiens protein ( Homo sapiens ... 53 3e-06
AK001991-1|BAA92025.1| 273|Homo sapiens protein ( Homo sapiens ... 53 3e-06
AB067497-1|BAB67803.1| 760|Homo sapiens KIAA1910 protein protein. 53 3e-06
M65153-1|AAA52287.1| 394|Homo sapiens biglycan protein. 53 4e-06
BC101073-1|AAI01074.1| 841|Homo sapiens SLIT and NTRK-like fami... 53 4e-06
BC101072-1|AAI01073.1| 841|Homo sapiens SLIT and NTRK-like fami... 53 4e-06
BC101071-1|AAI01072.1| 841|Homo sapiens SLIT and NTRK-like fami... 53 4e-06
BC101070-1|AAI01071.1| 841|Homo sapiens SLIT and NTRK-like fami... 53 4e-06
AK026427-1|BAB15480.1| 440|Homo sapiens protein ( Homo sapiens ... 53 4e-06
AK000338-1|BAA91094.1| 384|Homo sapiens protein ( Homo sapiens ... 53 4e-06
>AY313607-1|AAP79898.1| 613|Homo sapiens podocan protein protein.
Length = 613
Score = 111 bits (268), Expect = 7e-24
Identities = 121/478 (25%), Positives = 217/478 (45%), Gaps = 28/478 (5%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK-FPESLSRLHNLVNLDISSN 95
C C+ + +DC L + P L L++ NN+ K +PE LSRLH L L++ +N
Sbjct: 72 CACSQEGV-VDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNN 130
Query: 96 QL--KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
+L +GLP+ A +LT L L L+ N L L P LP + + D + N +
Sbjct: 131 RLTSRGLPEKAFEHLTNLNYLYLANNK----LTLAPR--FLPNALISV-DFAANYLTKIY 183
Query: 154 NLANQELLIRPSLETLILDHCEI-NSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
L + +P+L ++ L + ++ ++ + +G N+ VL L+ N L + + +L
Sbjct: 184 GLTFGQ---KPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPAL 240
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCNI 271
L + N +L + L SL L + NNY + + SL+Y+D+S N
Sbjct: 241 YKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLS-SNN 299
Query: 272 LQPNLKGFP-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI--ASLRYDTFRGLK 328
L G P SL L N +R +++N LEYL L +N + + F+GLK
Sbjct: 300 LSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLK 359
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT- 387
L + L N + +P + +L L + R + + L++S + +
Sbjct: 360 RLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSP 419
Query: 388 -IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLT 446
+ +D+ L+ + LDLS N L +P + N + L + N ++++ + +L
Sbjct: 420 QVHRDAFRKLRLLRSLDLSGNRLHMLPPGLPRN-VHVLKVKRNELAALARGALAGMAQLR 478
Query: 447 SLSVVGNRF--TMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNK 502
L + NR + R++ D +L+ LD++ N + E + + +++ L+ NK
Sbjct: 479 ELYLTSNRLRSRALGPRAWVDL-AHLQLLDIAGN--QLTEIPEGLPESLEYLYLQNNK 533
Score = 58.8 bits (136), Expect = 7e-08
Identities = 99/380 (26%), Positives = 171/380 (45%), Gaps = 58/380 (15%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL--KGLPDNALYNLT 109
L +P L + KL++ NN+ K P + S L +L L + +N L +GL + + L+
Sbjct: 229 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 288
Query: 110 ALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETL 169
+LE L+LS N NL+ LP + L +L L N +++ AN IR SLE L
Sbjct: 289 SLEYLDLSSN------NLSRVPAGLPRS-LVLLHLEKNAIRSVD--ANVLTPIR-SLEYL 338
Query: 170 ILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
+L ++ G PL+ GL + + L N L R+ + + +R+L + + ++T +
Sbjct: 339 LLHSNQLRE-QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 397
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQS--LKYIDIS--YCNILQPNLK------ 277
+ L L +S N R+ + F + L+ +D+S ++L P L
Sbjct: 398 EDFATTYFLEELNLSYN-RITSPQVHRDAFRKLRLLRSLDLSGNRLHMLPPGLPRNVHVL 456
Query: 278 ----------------GFPSLRKAILNHNMVRY--LESNAFANNTELEYLDLSNNNIASL 319
G LR+ L N +R L A+ + L+ LD++ N + +
Sbjct: 457 KVKRNELAALARGALAGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEI 516
Query: 320 RYDTFRGL-KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL------RS 372
GL + L++L L N+I+ +P ++ P+L + L N L+ VG + R
Sbjct: 517 P----EGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA-VGSVVDSAFRRL 571
Query: 373 MSVTILDM-SSCELNTIGKD 391
+ +LD+ + E I KD
Sbjct: 572 KHLQVLDIEGNLEFGDISKD 591
Score = 32.7 bits (71), Expect = 4.9
Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLK--GLPD 102
+D + LT+IP GL + L + NN+ + P + NL + + N+L + D
Sbjct: 506 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 565
Query: 103 NALYNLTALEVLNLSRN 119
+A L L+VL++ N
Sbjct: 566 SAFRRLKHLQVLDIEGN 582
>AL445183-5|CAH72592.1| 642|Homo sapiens podocan protein.
Length = 642
Score = 111 bits (268), Expect = 7e-24
Identities = 121/478 (25%), Positives = 217/478 (45%), Gaps = 28/478 (5%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK-FPESLSRLHNLVNLDISSN 95
C C+ + +DC L + P L L++ NN+ K +PE LSRLH L L++ +N
Sbjct: 101 CACSQEGV-VDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNN 159
Query: 96 QL--KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
+L +GLP+ A +LT L L L+ N L L P LP + + D + N +
Sbjct: 160 RLTSRGLPEKAFEHLTNLNYLYLANNK----LTLAPR--FLPNALISV-DFAANYLTKIY 212
Query: 154 NLANQELLIRPSLETLILDHCEI-NSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
L + +P+L ++ L + ++ ++ + +G N+ VL L+ N L + + +L
Sbjct: 213 GLTFGQ---KPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPAL 269
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCNI 271
L + N +L + L SL L + NNY + + SL+Y+D+S N
Sbjct: 270 YKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLS-SNN 328
Query: 272 LQPNLKGFP-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI--ASLRYDTFRGLK 328
L G P SL L N +R +++N LEYL L +N + + F+GLK
Sbjct: 329 LSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLK 388
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT- 387
L + L N + +P + +L L + R + + L++S + +
Sbjct: 389 RLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSP 448
Query: 388 -IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLT 446
+ +D+ L+ + LDLS N L +P + N + L + N ++++ + +L
Sbjct: 449 QVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN-VHVLKVKRNELAALARGALVGMAQLR 507
Query: 447 SLSVVGNRF--TMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNK 502
L + NR + R++ D +L+ LD++ N + E + + +++ L+ NK
Sbjct: 508 ELYLTSNRLRSRALGPRAWVDL-AHLQLLDIAGN--QLTEIPEGLPESLEYLYLQNNK 562
Score = 58.0 bits (134), Expect = 1e-07
Identities = 99/380 (26%), Positives = 170/380 (44%), Gaps = 58/380 (15%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL--KGLPDNALYNLT 109
L +P L + KL++ NN+ K P + S L +L L + +N L +GL + + L+
Sbjct: 258 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 317
Query: 110 ALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETL 169
+LE L+LS N NL+ LP + L +L L N +++ AN IR SLE L
Sbjct: 318 SLEYLDLSSN------NLSRVPAGLPRS-LVLLHLEKNAIRSVD--ANVLTPIR-SLEYL 367
Query: 170 ILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
+L ++ G PL+ GL + + L N L R+ + + +R+L + + ++T +
Sbjct: 368 LLHSNQLRE-QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 426
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQS--LKYIDIS--YCNILQPNLK------ 277
+ L L +S N R+ + F + L+ +D+S + L P L
Sbjct: 427 EDFATTYFLEELNLSYN-RITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVL 485
Query: 278 ----------------GFPSLRKAILNHNMVRY--LESNAFANNTELEYLDLSNNNIASL 319
G LR+ L N +R L A+ + L+ LD++ N + +
Sbjct: 486 KVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEI 545
Query: 320 RYDTFRGL-KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL------RS 372
GL + L++L L N+I+ +P ++ P+L + L N L+ VG + R
Sbjct: 546 P----EGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA-VGSVVDSAFRRL 600
Query: 373 MSVTILDM-SSCELNTIGKD 391
+ +LD+ + E I KD
Sbjct: 601 KHLQVLDIEGNLEFGDISKD 620
Score = 32.7 bits (71), Expect = 4.9
Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLK--GLPD 102
+D + LT+IP GL + L + NN+ + P + NL + + N+L + D
Sbjct: 535 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 594
Query: 103 NALYNLTALEVLNLSRN 119
+A L L+VL++ N
Sbjct: 595 SAFRRLKHLQVLDIEGN 611
>AL445183-4|CAH72591.1| 661|Homo sapiens podocan protein.
Length = 661
Score = 111 bits (268), Expect = 7e-24
Identities = 121/478 (25%), Positives = 217/478 (45%), Gaps = 28/478 (5%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK-FPESLSRLHNLVNLDISSN 95
C C+ + +DC L + P L L++ NN+ K +PE LSRLH L L++ +N
Sbjct: 120 CACSQEGV-VDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNN 178
Query: 96 QL--KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
+L +GLP+ A +LT L L L+ N L L P LP + + D + N +
Sbjct: 179 RLTSRGLPEKAFEHLTNLNYLYLANNK----LTLAPR--FLPNALISV-DFAANYLTKIY 231
Query: 154 NLANQELLIRPSLETLILDHCEI-NSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
L + +P+L ++ L + ++ ++ + +G N+ VL L+ N L + + +L
Sbjct: 232 GLTFGQ---KPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPAL 288
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCNI 271
L + N +L + L SL L + NNY + + SL+Y+D+S N
Sbjct: 289 YKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLS-SNN 347
Query: 272 LQPNLKGFP-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI--ASLRYDTFRGLK 328
L G P SL L N +R +++N LEYL L +N + + F+GLK
Sbjct: 348 LSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLK 407
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT- 387
L + L N + +P + +L L + R + + L++S + +
Sbjct: 408 RLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSP 467
Query: 388 -IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLT 446
+ +D+ L+ + LDLS N L +P + N + L + N ++++ + +L
Sbjct: 468 QVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN-VHVLKVKRNELAALARGALVGMAQLR 526
Query: 447 SLSVVGNRF--TMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNK 502
L + NR + R++ D +L+ LD++ N + E + + +++ L+ NK
Sbjct: 527 ELYLTSNRLRSRALGPRAWVDL-AHLQLLDIAGN--QLTEIPEGLPESLEYLYLQNNK 581
Score = 58.0 bits (134), Expect = 1e-07
Identities = 99/380 (26%), Positives = 170/380 (44%), Gaps = 58/380 (15%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL--KGLPDNALYNLT 109
L +P L + KL++ NN+ K P + S L +L L + +N L +GL + + L+
Sbjct: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
Query: 110 ALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETL 169
+LE L+LS N NL+ LP + L +L L N +++ AN IR SLE L
Sbjct: 337 SLEYLDLSSN------NLSRVPAGLPRS-LVLLHLEKNAIRSVD--ANVLTPIR-SLEYL 386
Query: 170 ILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
+L ++ G PL+ GL + + L N L R+ + + +R+L + + ++T +
Sbjct: 387 LLHSNQLRE-QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 445
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQS--LKYIDIS--YCNILQPNLK------ 277
+ L L +S N R+ + F + L+ +D+S + L P L
Sbjct: 446 EDFATTYFLEELNLSYN-RITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVL 504
Query: 278 ----------------GFPSLRKAILNHNMVRY--LESNAFANNTELEYLDLSNNNIASL 319
G LR+ L N +R L A+ + L+ LD++ N + +
Sbjct: 505 KVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEI 564
Query: 320 RYDTFRGL-KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL------RS 372
GL + L++L L N+I+ +P ++ P+L + L N L+ VG + R
Sbjct: 565 P----EGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA-VGSVVDSAFRRL 619
Query: 373 MSVTILDM-SSCELNTIGKD 391
+ +LD+ + E I KD
Sbjct: 620 KHLQVLDIEGNLEFGDISKD 639
Score = 32.7 bits (71), Expect = 4.9
Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLK--GLPD 102
+D + LT+IP GL + L + NN+ + P + NL + + N+L + D
Sbjct: 554 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 613
Query: 103 NALYNLTALEVLNLSRN 119
+A L L+VL++ N
Sbjct: 614 SAFRRLKHLQVLDIEGN 630
>BC030608-1|AAH30608.1| 661|Homo sapiens podocan protein.
Length = 661
Score = 111 bits (267), Expect = 9e-24
Identities = 121/478 (25%), Positives = 217/478 (45%), Gaps = 28/478 (5%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK-FPESLSRLHNLVNLDISSN 95
C C+ + +DC L + P L L++ NN+ K +PE LSRLH L L++ +N
Sbjct: 120 CACSQEGV-VDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNN 178
Query: 96 QL--KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
+L +GLP+ A +LT L L L+ N L L P LP + + D + N +
Sbjct: 179 RLTSRGLPEKAFEHLTNLNYLYLANNK----LTLAPR--FLPNALISV-DFAANYLTKIY 231
Query: 154 NLANQELLIRPSLETLILDHCEI-NSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
L + +P+L ++ L + ++ ++ + +G N+ VL L+ N L + + +L
Sbjct: 232 GLTFGQ---KPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPAL 288
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCNI 271
L + N +L + L SL L + NNY + + SL+Y+D+S N
Sbjct: 289 YKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLS-SNN 347
Query: 272 LQPNLKGFP-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI--ASLRYDTFRGLK 328
L G P SL L N +R +++N LEYL L +N + + F+GLK
Sbjct: 348 LSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLK 407
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT- 387
L + L N + +P + +L L + R + + L++S + +
Sbjct: 408 RLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSP 467
Query: 388 -IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLT 446
+ +D+ L+ + LDLS N L +P + N + L + N ++++ + +L
Sbjct: 468 QVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN-VHVLKVKRNELAALARGALAGMAQLR 526
Query: 447 SLSVVGNRF--TMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNK 502
L + NR + R++ D +L+ LD++ N + E + + +++ L+ NK
Sbjct: 527 ELYLTSNRLRSRALGPRAWVDL-AHLQLLDIAGN--QLTEIPEGLPESLEYLYLQNNK 581
Score = 58.0 bits (134), Expect = 1e-07
Identities = 99/380 (26%), Positives = 170/380 (44%), Gaps = 58/380 (15%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL--KGLPDNALYNLT 109
L +P L + KL++ NN+ K P + S L +L L + +N L +GL + + L+
Sbjct: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
Query: 110 ALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETL 169
+LE L+LS N NL+ LP + L +L L N +++ AN IR SLE L
Sbjct: 337 SLEYLDLSSN------NLSRVPAGLPRS-LVLLHLEKNAIRSVD--ANVLTPIR-SLEYL 386
Query: 170 ILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
+L ++ G PL+ GL + + L N L R+ + + +R+L + + ++T +
Sbjct: 387 LLHSNQLRE-QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 445
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQS--LKYIDIS--YCNILQPNLK------ 277
+ L L +S N R+ + F + L+ +D+S + L P L
Sbjct: 446 EDFATTYFLEELNLSYN-RITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVL 504
Query: 278 ----------------GFPSLRKAILNHNMVRY--LESNAFANNTELEYLDLSNNNIASL 319
G LR+ L N +R L A+ + L+ LD++ N + +
Sbjct: 505 KVKRNELAALARGALAGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEI 564
Query: 320 RYDTFRGL-KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL------RS 372
GL + L++L L N+I+ +P ++ P+L + L N L+ VG + R
Sbjct: 565 P----EGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA-VGSVVDSAFRRL 619
Query: 373 MSVTILDM-SSCELNTIGKD 391
+ +LD+ + E I KD
Sbjct: 620 KHLQVLDIEGNLEFGDISKD 639
Score = 32.7 bits (71), Expect = 4.9
Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLK--GLPD 102
+D + LT+IP GL + L + NN+ + P + NL + + N+L + D
Sbjct: 554 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 613
Query: 103 NALYNLTALEVLNLSRN 119
+A L L+VL++ N
Sbjct: 614 SAFRRLKHLQVLDIEGN 630
>AY358294-1|AAQ88661.1| 642|Homo sapiens EGEE293 protein.
Length = 642
Score = 111 bits (267), Expect = 9e-24
Identities = 121/478 (25%), Positives = 217/478 (45%), Gaps = 28/478 (5%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK-FPESLSRLHNLVNLDISSN 95
C C+ + +DC L + P L L++ NN+ K +PE LSRLH L L++ +N
Sbjct: 101 CACSQEGV-VDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNN 159
Query: 96 QL--KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
+L +GLP+ A +LT L L L+ N L L P LP + + D + N +
Sbjct: 160 RLTSRGLPEKAFEHLTNLNYLYLANNK----LTLAPR--FLPNALISV-DFAANYLTKIY 212
Query: 154 NLANQELLIRPSLETLILDHCEI-NSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
L + +P+L ++ L + ++ ++ + +G N+ VL L+ N L + + +L
Sbjct: 213 GLTFGQ---KPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPAL 269
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCNI 271
L + N +L + L SL L + NNY + + SL+Y+D+S N
Sbjct: 270 YKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLS-SNN 328
Query: 272 LQPNLKGFP-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI--ASLRYDTFRGLK 328
L G P SL L N +R +++N LEYL L +N + + F+GLK
Sbjct: 329 LSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLK 388
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT- 387
L + L N + +P + +L L + R + + L++S + +
Sbjct: 389 RLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSP 448
Query: 388 -IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLT 446
+ +D+ L+ + LDLS N L +P + N + L + N ++++ + +L
Sbjct: 449 QVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN-VHVLKVKRNELAALARGALAGMAQLR 507
Query: 447 SLSVVGNRF--TMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNK 502
L + NR + R++ D +L+ LD++ N + E + + +++ L+ NK
Sbjct: 508 ELYLTSNRLRSRALGPRAWVDL-AHLQLLDIAGN--QLTEIPEGLPESLEYLYLQNNK 562
Score = 58.0 bits (134), Expect = 1e-07
Identities = 99/380 (26%), Positives = 170/380 (44%), Gaps = 58/380 (15%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL--KGLPDNALYNLT 109
L +P L + KL++ NN+ K P + S L +L L + +N L +GL + + L+
Sbjct: 258 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 317
Query: 110 ALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETL 169
+LE L+LS N NL+ LP + L +L L N +++ AN IR SLE L
Sbjct: 318 SLEYLDLSSN------NLSRVPAGLPRS-LVLLHLEKNAIRSVD--ANVLTPIR-SLEYL 367
Query: 170 ILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
+L ++ G PL+ GL + + L N L R+ + + +R+L + + ++T +
Sbjct: 368 LLHSNQLRE-QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 426
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQS--LKYIDIS--YCNILQPNLK------ 277
+ L L +S N R+ + F + L+ +D+S + L P L
Sbjct: 427 EDFATTYFLEELNLSYN-RITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVL 485
Query: 278 ----------------GFPSLRKAILNHNMVRY--LESNAFANNTELEYLDLSNNNIASL 319
G LR+ L N +R L A+ + L+ LD++ N + +
Sbjct: 486 KVKRNELAALARGALAGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEI 545
Query: 320 RYDTFRGL-KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL------RS 372
GL + L++L L N+I+ +P ++ P+L + L N L+ VG + R
Sbjct: 546 P----EGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA-VGSVVDSAFRRL 600
Query: 373 MSVTILDM-SSCELNTIGKD 391
+ +LD+ + E I KD
Sbjct: 601 KHLQVLDIEGNLEFGDISKD 620
Score = 32.7 bits (71), Expect = 4.9
Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLK--GLPD 102
+D + LT+IP GL + L + NN+ + P + NL + + N+L + D
Sbjct: 535 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 594
Query: 103 NALYNLTALEVLNLSRN 119
+A L L+VL++ N
Sbjct: 595 SAFRRLKHLQVLDIEGN 611
>BC033039-1|AAH33039.1| 927|Homo sapiens LGR4 protein protein.
Length = 927
Score = 110 bits (264), Expect = 2e-23
Identities = 114/392 (29%), Positives = 178/392 (45%), Gaps = 38/392 (9%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ D+ +DCS +GLT +P GL L ++ N+ + P++LS L L L + +N
Sbjct: 33 CSCDGDRR-VDCSGKGLTAVPEGLSAFTQALQLAGNDLSFIHPKALSGLKELKVLTLQNN 91
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDS---------------WLNLN-----PNDVLLP 135
QLK +P A+ L+AL+ L L N+ S WL+ N P L
Sbjct: 92 QLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHHLSN 151
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
L+ L L+ NK ++ + A L SL L L + +I S+ + GL N+ L
Sbjct: 152 LPTLQALTLALNKISSIPDFAFTNL---SSLVVLHLHNNKIRSL-SQHCFDGLDNLETLD 207
Query: 196 LNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA 253
LN+N L I + SL+ L + ++ + P L + + +N + +SA
Sbjct: 208 LNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 267
Query: 254 NNLFSQSLKYIDISYCNILQ--PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL 311
+ S L + I +++Q PNL G L L + + +N L LDL
Sbjct: 268 FHNLS-DLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL 326
Query: 312 SNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLR 371
S NNI L +F G L+ + L N+I I E + + SL L LSRN + + H R
Sbjct: 327 SYNNIRDL--PSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEI-HSR 383
Query: 372 SMS----VTILDMSSCELNTIGKDSLEGLQSI 399
+ + +T LD+S EL + + L GL +
Sbjct: 384 AFATLGPITNLDVSFNELTSFPTEGLNGLNQL 415
Score = 91.5 bits (217), Expect = 1e-17
Identities = 91/309 (29%), Positives = 141/309 (45%), Gaps = 23/309 (7%)
Query: 62 LQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
+Q+ L + +N T+ P LS L L L ++ N++ +PD A NL++L VL+L N
Sbjct: 129 VQLRHLWLDDNSLTEVPVHHLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNK 188
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
S L+ + D L +L+ LDL++N +G Q + PSL+ L H S+
Sbjct: 189 IRS-LSQHCFDGL---DNLETLDLNYNN---LGEFP-QAIKALPSLKELGF-HSNSISVI 239
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLT 237
G +R + L NPL + N S L SL + + N L
Sbjct: 240 PDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPN----LTGTV 295
Query: 238 HLKMSNNYRLELASSANNLFSQS--LKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRY 294
HL+ +++S NNL + L+ +D+SY NI P+ G +L + L N +
Sbjct: 296 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQ 355
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
++ F L LDLS N I + F L + +LD+S+NE+ P + L L
Sbjct: 356 IKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGL---NGL 412
Query: 355 TQLKLSRNY 363
QLKL N+
Sbjct: 413 NQLKLVGNF 421
Score = 79.0 bits (186), Expect = 6e-14
Identities = 56/211 (26%), Positives = 101/211 (47%), Gaps = 4/211 (1%)
Query: 257 FSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
F+Q+L+ I L G L+ L +N ++ + S A + L+ L L N+I
Sbjct: 58 FTQALQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHI 117
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSM 373
S+ D+F GL L+HL L N + +P L +P+L L L+ N +S +
Sbjct: 118 TSVPEDSFEGLVQLRHLWLDDNSLTEVPVHHLSNLPTLQALTLALNKISSIPDFAFTNLS 177
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRIS 432
S+ +L + + ++ ++ + +GL ++ LDL+ N L P +I + +LK L + N IS
Sbjct: 178 SLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSIS 237
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSF 463
I + F L ++ + N + + +F
Sbjct: 238 VIPDGAFDGNPLLRTIHLYDNPLSFVGNSAF 268
Score = 65.3 bits (152), Expect = 8e-10
Identities = 89/335 (26%), Positives = 147/335 (43%), Gaps = 34/335 (10%)
Query: 175 EINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS---SSLRSLFVSNCELTSLNHNELM 231
+++ IH ++ LSGL ++VL L N L + + S+L+SL + +TS+ +
Sbjct: 68 DLSFIHPKA-LSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFE 126
Query: 232 FLPSLTHLKMSNNYRLEL-ASSANNLFS-QSLKYIDISYCNILQPNLKGFPSLRKAILNH 289
L L HL + +N E+ +NL + Q+L +I SL L++
Sbjct: 127 GLVQLRHLWLDDNSLTEVPVHHLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHN 186
Query: 290 NMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
N +R L + F LE LDL+ NN+ + L LK L N I+VIP+ +
Sbjct: 187 NKIRSLSQHCFDGLDNLETLDLNYNNLGEFP-QAIKALPSLKELGFHSNSISVIPDGAFD 245
Query: 350 EMPSLTQLKLSRNYLSRVGH-------------LRSMSV---------TI----LDMSSC 383
P L + L N LS VG+ +R S+ T+ L ++
Sbjct: 246 GNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGT 305
Query: 384 ELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLN 443
++++I + + + + LDLS N + +P + L+ ++L N+I I TF L
Sbjct: 306 KISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLI 365
Query: 444 RLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L L + N I R+F P + LD+S N
Sbjct: 366 SLRILDLSRNLIHEIHSRAFATLGP-ITNLDVSFN 399
Score = 38.7 bits (86), Expect = 0.075
Identities = 50/187 (26%), Positives = 82/187 (43%), Gaps = 17/187 (9%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+LS LH+LV S ++ P+ L LE L L+ S PN++ L
Sbjct: 270 NLSDLHSLVIRGAS--MVQQFPN--LTGTVHLESLTLTGTKISSI----PNNLCQEQKML 321
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ LDLS+N + + + +LE + L +I I GLI++R+L L+ N
Sbjct: 322 RTLDLSYNNIRDLPSFNGCH-----ALEEISLQRNQIYQIK-EGTFQGLISLRILDLSRN 375
Query: 200 PLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN---NL 256
+ I + ++L + + L L L LK+ N++L+ A +A NL
Sbjct: 376 LIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNL 435
Query: 257 FSQSLKY 263
S S+ Y
Sbjct: 436 RSLSVPY 442
>AB209743-1|BAD92980.1| 1032|Homo sapiens Leucine-rich
repeat-containing G protein-coupled receptor 4 precursor
variant protein.
Length = 1032
Score = 106 bits (254), Expect = 3e-22
Identities = 117/426 (27%), Positives = 189/426 (44%), Gaps = 23/426 (5%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSN 95
C C+ D+ +DCS +GLT +P GL L+IS N T+ PE + L L ++ N
Sbjct: 114 CSCDGDRR-VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGN 172
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
L + AL L L+VL L N L P++ + + L+ L L N ++
Sbjct: 173 DLSFIHPKALSGLKELKVLTLQNNQ----LKTVPSEAIRGLSALQSLRLDANHITSVPED 228
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
+ + L+ L L LD + + PLS L ++ L L N + I + ++L SL
Sbjct: 229 SFEGLV---QLRHLWLDDNSLTEVPVH-PLSNLPTLQALTLALNKISSIPDFAFTNLSSL 284
Query: 216 FV---SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCNI 271
V N ++ SL+ + L +L L ++ N E + L S + L + S I
Sbjct: 285 VVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVI 344
Query: 272 LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLK 331
G P LR L N + ++ ++AF N ++L L + ++ ++ G L+
Sbjct: 345 PDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQ-QFPNLTGTVHLE 403
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM-SVTILDMSSCELNTIGK 390
L L+ +I+ IP + E L L LS N + + ++ + + ++ I +
Sbjct: 404 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKE 463
Query: 391 DSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFM---LNRLTS 447
+ +GL S+ LDLS+NL+ I S L N S N LT F LN L
Sbjct: 464 GTFQGLISLRILDLSRNLI----HEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQ 519
Query: 448 LSVVGN 453
L +VGN
Sbjct: 520 LKLVGN 525
Score = 91.5 bits (217), Expect = 1e-17
Identities = 91/309 (29%), Positives = 141/309 (45%), Gaps = 23/309 (7%)
Query: 62 LQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
+Q+ L + +N T+ P LS L L L ++ N++ +PD A NL++L VL+L N
Sbjct: 234 VQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNK 293
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
S L+ + D L +L+ LDL++N +G Q + PSL+ L H S+
Sbjct: 294 IRS-LSQHCFDGL---DNLETLDLNYNN---LGEFP-QAIKALPSLKELGF-HSNSISVI 344
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLT 237
G +R + L NPL + N S L SL + + N L
Sbjct: 345 PDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPN----LTGTV 400
Query: 238 HLKMSNNYRLELASSANNLFSQS--LKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRY 294
HL+ +++S NNL + L+ +D+SY NI P+ G +L + L N +
Sbjct: 401 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQ 460
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
++ F L LDLS N I + F L + +LD+S+NE+ P + L L
Sbjct: 461 IKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGL---NGL 517
Query: 355 TQLKLSRNY 363
QLKL N+
Sbjct: 518 NQLKLVGNF 526
Score = 84.2 bits (199), Expect = 2e-15
Identities = 114/421 (27%), Positives = 194/421 (46%), Gaps = 45/421 (10%)
Query: 66 KLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+++ S T PE LS LDIS N + LP++A N LE L L+ N
Sbjct: 121 RVDCSGKGLTAVPEGLSAFTQA--LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF-- 176
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
++P L LK+L L N+ +T+ + A + L +L++L LD I S+ S
Sbjct: 177 -IHPK-ALSGLKELKVLTLQNNQLKTVPSEAIRGL---SALQSLRLDANHITSVPEDS-F 230
Query: 186 SGLINIRVLKLNFNPLLRIQ-NLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
GL+ +R L L+ N L + + +S+ +L++L ++ +++S+ L SL L +
Sbjct: 231 EGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLH 290
Query: 243 NNYRLELASSANNLFS--QSLKYIDISYCNILQ-PN-LKGFPSLRKAILNHNMVRYLESN 298
NN ++ S + + F +L+ +D++Y N+ + P +K PSL++ + N + +
Sbjct: 291 NN---KIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDG 347
Query: 299 AFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM-PSLTQL 357
AF N L + L +N ++ + F L L L VI S+++ P+LT
Sbjct: 348 AFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSL--------VIRGASMVQQFPNLTGT 399
Query: 358 KLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSIS 417
HL S+++T +SS N + + + LDLS N + +P
Sbjct: 400 V----------HLESLTLTGTKISSIPNNLCQEQKM-----LRTLDLSYNNIRDLPSFNG 444
Query: 418 SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSD 477
+ L+ ++L N+I I TF L L L + N I R+F P + LD+S
Sbjct: 445 CHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP-ITNLDVSF 503
Query: 478 N 478
N
Sbjct: 504 N 504
Score = 38.7 bits (86), Expect = 0.075
Identities = 50/187 (26%), Positives = 82/187 (43%), Gaps = 17/187 (9%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+LS LH+LV S ++ P+ L LE L L+ S PN++ L
Sbjct: 375 NLSDLHSLVIRGAS--MVQQFPN--LTGTVHLESLTLTGTKISSI----PNNLCQEQKML 426
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ LDLS+N + + + +LE + L +I I GLI++R+L L+ N
Sbjct: 427 RTLDLSYNNIRDLPSFNGCH-----ALEEISLQRNQIYQIK-EGTFQGLISLRILDLSRN 480
Query: 200 PLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN---NL 256
+ I + ++L + + L L L LK+ N++L+ A +A NL
Sbjct: 481 LIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNL 540
Query: 257 FSQSLKY 263
S S+ Y
Sbjct: 541 RSLSVPY 547
>AF346711-1|AAK31153.1| 951|Homo sapiens G-protein couple receptor
protein.
Length = 951
Score = 103 bits (247), Expect = 2e-21
Identities = 116/426 (27%), Positives = 187/426 (43%), Gaps = 23/426 (5%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSN 95
C C+ D+ +DCS +GLT +P GL L+IS N T+ PE + L L ++ N
Sbjct: 33 CSCDGDRR-VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGN 91
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
L + AL L L+VL L N L P++ + + L+ L L N ++
Sbjct: 92 DLSFIHPKALSGLKELKVLTLQNNQ----LKTVPSEAIRGLSALQSLRLDANHITSVPED 147
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
+ + L+ L L LD + + PLS L ++ L L N + I + ++L SL
Sbjct: 148 SFEGLV---QLRHLWLDDNSLTEVPVH-PLSNLPTLQALTLALNKISSIPDFAFTNLSSL 203
Query: 216 FV---SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCNI 271
V N ++ L+ + L +L L +S N E + S + L + S I
Sbjct: 204 VVLHLHNNKIRGLSQHCFDGLDNLETLDLSYNNLGEFPQAIKARPSLKELGFHSNSISVI 263
Query: 272 LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLK 331
G P LR L N + ++ ++AF N ++L L + ++ ++ G L+
Sbjct: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQ-QFPNLTGTVHLE 322
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM-SVTILDMSSCELNTIGK 390
L L+ +I+ IP + E L L LS N + + ++ + + ++ I +
Sbjct: 323 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKE 382
Query: 391 DSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFM---LNRLTS 447
+ +GL S+ LDLS+NL+ I S L N S N LT F LN L
Sbjct: 383 GTFQGLISLRILDLSRNLI----HEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQ 438
Query: 448 LSVVGN 453
L +VGN
Sbjct: 439 LKLVGN 444
Score = 93.9 bits (223), Expect = 2e-18
Identities = 92/309 (29%), Positives = 141/309 (45%), Gaps = 23/309 (7%)
Query: 62 LQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
+Q+ L + +N T+ P LS L L L ++ N++ +PD A NL++L VL+L N
Sbjct: 153 VQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNK 212
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
L+ + D L +L+ LDLS+N +G Q + RPSL+ L H S+
Sbjct: 213 IRG-LSQHCFDGL---DNLETLDLSYNN---LGEFP-QAIKARPSLKELGF-HSNSISVI 263
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLT 237
G +R + L NPL + N S L SL + + N L
Sbjct: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPN----LTGTV 319
Query: 238 HLKMSNNYRLELASSANNLFSQS--LKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRY 294
HL+ +++S NNL + L+ +D+SY NI P+ G +L + L N +
Sbjct: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQ 379
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
++ F L LDLS N I + F L + +LD+S+NE+ P + L L
Sbjct: 380 IKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGL---NGL 436
Query: 355 TQLKLSRNY 363
QLKL N+
Sbjct: 437 NQLKLVGNF 445
Score = 82.6 bits (195), Expect = 5e-15
Identities = 114/421 (27%), Positives = 193/421 (45%), Gaps = 45/421 (10%)
Query: 66 KLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+++ S T PE LS LDIS N + LP++A N LE L L+ N
Sbjct: 40 RVDCSGKGLTAVPEGLSAFTQA--LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF-- 95
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
++P L LK+L L N+ +T+ + A + L +L++L LD I S+ S
Sbjct: 96 -IHPK-ALSGLKELKVLTLQNNQLKTVPSEAIRGL---SALQSLRLDANHITSVPEDS-F 149
Query: 186 SGLINIRVLKLNFNPLLRIQ-NLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
GL+ +R L L+ N L + + +S+ +L++L ++ +++S+ L SL L +
Sbjct: 150 EGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLH 209
Query: 243 NNYRLELASSANNLFS--QSLKYIDISYCNILQ-PN-LKGFPSLRKAILNHNMVRYLESN 298
NN ++ + + F +L+ +D+SY N+ + P +K PSL++ + N + +
Sbjct: 210 NN---KIRGLSQHCFDGLDNLETLDLSYNNLGEFPQAIKARPSLKELGFHSNSISVIPDG 266
Query: 299 AFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM-PSLTQL 357
AF N L + L +N ++ + F L L L VI S+++ P+LT
Sbjct: 267 AFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSL--------VIRGASMVQQFPNLTGT 318
Query: 358 KLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSIS 417
HL S+++T +SS N + + + LDLS N + +P
Sbjct: 319 V----------HLESLTLTGTKISSIPNNLCQEQKM-----LRTLDLSYNNIRDLPSFNG 363
Query: 418 SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSD 477
+ L+ ++L N+I I TF L L L + N I R+F P + LD+S
Sbjct: 364 CHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP-ITNLDVSF 422
Query: 478 N 478
N
Sbjct: 423 N 423
Score = 38.7 bits (86), Expect = 0.075
Identities = 50/187 (26%), Positives = 82/187 (43%), Gaps = 17/187 (9%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+LS LH+LV S ++ P+ L LE L L+ S PN++ L
Sbjct: 294 NLSDLHSLVIRGAS--MVQQFPN--LTGTVHLESLTLTGTKISSI----PNNLCQEQKML 345
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ LDLS+N + + + +LE + L +I I GLI++R+L L+ N
Sbjct: 346 RTLDLSYNNIRDLPSFNGCH-----ALEEISLQRNQIYQIK-EGTFQGLISLRILDLSRN 399
Query: 200 PLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN---NL 256
+ I + ++L + + L L L LK+ N++L+ A +A NL
Sbjct: 400 LIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNL 459
Query: 257 FSQSLKY 263
S S+ Y
Sbjct: 460 RSLSVPY 466
>BC025681-1|AAH25681.1| 605|Homo sapiens insulin-like growth factor
binding protein, acid labile subunit protein.
Length = 605
Score = 101 bits (243), Expect = 7e-21
Identities = 142/507 (28%), Positives = 216/507 (42%), Gaps = 66/507 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGL--GLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKG 99
D+ + CS R LT +P+G+ G Q L+ NN + P + L +L L++ QL
Sbjct: 54 DELSVFCSSRNLTRLPDGVPGGTQALWLD-GNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 112
Query: 100 LPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQE 159
L AL L L L+L RN S L L PA L L LS N+ + + +
Sbjct: 113 LEPQALLGLENLCHLHLERNQLRS-LALG-TFAHTPA--LASLGLSNNRLSRLEDGLFEG 168
Query: 160 LLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISS---SLRSLF 216
L SL L L + ++ + GL ++R L L N L +Q + S LR L
Sbjct: 169 L---GSLWDLNLGWNSL-AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELD 224
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY---CNILQ 273
+S L ++ N + LP L L + N +A A L ++L+++D+S+ +L+
Sbjct: 225 LSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGA-FLGLKALRWLDLSHNRVAGLLE 283
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
G LR L+HN + L F + LE L L +N I L +F GL L+ L
Sbjct: 284 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 343
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL---------------------SRVGHLRS 372
L N++ + + L + ++ + LS N L S +G +R
Sbjct: 344 TLDHNQLQEVKAGAFLGLTNMAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRP 403
Query: 373 MSVTILD------MSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYL 424
+ T L + L I + SL GL ++ELDL+ N L+++P + L+YL
Sbjct: 404 HTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYL 463
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR-------------------RSFFD 465
L+ NR++ + L R L V NR + R+F
Sbjct: 464 LLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDF 492
P LERL L N W C C + +RDF
Sbjct: 524 QPPGLERLWLEGNPWDCGCPLKALRDF 550
Score = 83.8 bits (198), Expect = 2e-15
Identities = 77/271 (28%), Positives = 124/271 (45%), Gaps = 10/271 (3%)
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFA 301
NN ++ NL S + L+P L G +L L N +R L FA
Sbjct: 84 NNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFA 143
Query: 302 NNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR 361
+ L L LSNN ++ L F GL L L+L WN +AV+P+ + + SL +L L+
Sbjct: 144 HTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAG 203
Query: 362 N---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS--I 416
N YL + LD+S L I + L + +L L +NL++ + +
Sbjct: 204 NRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFL 263
Query: 417 SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
L++L+L++NR++ + TF L L L + N + R+F D + +LE L L
Sbjct: 264 GLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLH-FLEELQLG 322
Query: 477 DNMWR--CDCSDENMRDFYDFVTLEPNKKEE 505
N R + S E + + +TL+ N+ +E
Sbjct: 323 HNRIRQLAERSFEGLGQL-EVLTLDHNQLQE 352
>M86826-1|AAA36047.1| 605|Homo sapiens insulin-like growth factor
binding protein complex protein.
Length = 605
Score = 101 bits (242), Expect = 9e-21
Identities = 142/507 (28%), Positives = 216/507 (42%), Gaps = 66/507 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGL--GLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKG 99
D+ + CS R LT +P+G+ G Q L+ NN + P + L +L L++ QL
Sbjct: 54 DELSVFCSSRNLTRLPDGVPGGTQALWLD-GNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 112
Query: 100 LPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQE 159
L AL L L L+L RN S L L PA L L LS N+ + + +
Sbjct: 113 LEPQALLGLENLCHLHLERNQLRS-LALG-TFAHTPA--LASLGLSNNRLSRLEDGLFEG 168
Query: 160 LLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISS---SLRSLF 216
L SL L L + ++ + GL ++R L L N L +Q + S LR L
Sbjct: 169 L---GSLWDLNLGWNSL-AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELD 224
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY---CNILQ 273
+S L ++ N + LP L L + N +A A L ++L+++D+S+ +L+
Sbjct: 225 LSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGA-FLGLKALRWLDLSHNRVAGLLE 283
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
G LR L+HN + L F + LE L L +N I L +F GL L+ L
Sbjct: 284 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 343
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL---------------------SRVGHLRS 372
L N++ + + L + ++ + LS N L S +G +R
Sbjct: 344 TLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRP 403
Query: 373 MSVTILD------MSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYL 424
+ T L + L I + SL GL ++ELDL+ N L+++P + L+YL
Sbjct: 404 HTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYL 463
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR-------------------RSFFD 465
L+ NR++ + L R L V NR + R+F
Sbjct: 464 LLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDF 492
P LERL L N W C C + +RDF
Sbjct: 524 QPPGLERLWLEGNPWDCGCPLKALRDF 550
Score = 83.8 bits (198), Expect = 2e-15
Identities = 77/271 (28%), Positives = 124/271 (45%), Gaps = 10/271 (3%)
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFA 301
NN ++ NL S + L+P L G +L L N +R L FA
Sbjct: 84 NNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFA 143
Query: 302 NNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR 361
+ L L LSNN ++ L F GL L L+L WN +AV+P+ + + SL +L L+
Sbjct: 144 HTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAG 203
Query: 362 N---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS--I 416
N YL + LD+S L I + L + +L L +NL++ + +
Sbjct: 204 NRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFL 263
Query: 417 SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
L++L+L++NR++ + TF L L L + N + R+F D + +LE L L
Sbjct: 264 GLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLH-FLEELQLG 322
Query: 477 DNMWR--CDCSDENMRDFYDFVTLEPNKKEE 505
N R + S E + + +TL+ N+ +E
Sbjct: 323 HNRIRQLAERSFEGLGQL-EVLTLDHNQLQE 352
>AL031724-2|CAC36078.1| 605|Homo sapiens C447E6.2 (insulin-like
growth factor binding protein, acid labile subunit)
protein.
Length = 605
Score = 101 bits (242), Expect = 9e-21
Identities = 142/507 (28%), Positives = 216/507 (42%), Gaps = 66/507 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGL--GLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKG 99
D+ + CS R LT +P+G+ G Q L+ NN + P + L +L L++ QL
Sbjct: 54 DELSVFCSSRNLTRLPDGVPGGTQALWLD-GNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 112
Query: 100 LPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQE 159
L AL L L L+L RN S L L PA L L LS N+ + + +
Sbjct: 113 LEPQALLGLENLCHLHLERNQLRS-LALG-TFAHTPA--LASLGLSNNRLSRLEDGLFEG 168
Query: 160 LLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISS---SLRSLF 216
L SL L L + ++ + GL ++R L L N L +Q + S LR L
Sbjct: 169 L---GSLWDLNLGWNSL-AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELD 224
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY---CNILQ 273
+S L ++ N + LP L L + N +A A L ++L+++D+S+ +L+
Sbjct: 225 LSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGA-FLGLKALRWLDLSHNRVAGLLE 283
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
G LR L+HN + L F + LE L L +N I L +F GL L+ L
Sbjct: 284 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 343
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL---------------------SRVGHLRS 372
L N++ + + L + ++ + LS N L S +G +R
Sbjct: 344 TLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRP 403
Query: 373 MSVTILD------MSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYL 424
+ T L + L I + SL GL ++ELDL+ N L+++P + L+YL
Sbjct: 404 HTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYL 463
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR-------------------RSFFD 465
L+ NR++ + L R L V NR + R+F
Sbjct: 464 LLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDF 492
P LERL L N W C C + +RDF
Sbjct: 524 QPPGLERLWLEGNPWDCGCPLKALRDF 550
Score = 83.8 bits (198), Expect = 2e-15
Identities = 77/271 (28%), Positives = 124/271 (45%), Gaps = 10/271 (3%)
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFA 301
NN ++ NL S + L+P L G +L L N +R L FA
Sbjct: 84 NNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFA 143
Query: 302 NNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR 361
+ L L LSNN ++ L F GL L L+L WN +AV+P+ + + SL +L L+
Sbjct: 144 HTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAG 203
Query: 362 N---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS--I 416
N YL + LD+S L I + L + +L L +NL++ + +
Sbjct: 204 NRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFL 263
Query: 417 SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
L++L+L++NR++ + TF L L L + N + R+F D + +LE L L
Sbjct: 264 GLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLH-FLEELQLG 322
Query: 477 DNMWR--CDCSDENMRDFYDFVTLEPNKKEE 505
N R + S E + + +TL+ N+ +E
Sbjct: 323 HNRIRQLAERSFEGLGQL-EVLTLDHNQLQE 352
>AF192554-1|AAF06774.1| 605|Homo sapiens acid-labile subunit
protein.
Length = 605
Score = 101 bits (242), Expect = 9e-21
Identities = 142/507 (28%), Positives = 216/507 (42%), Gaps = 66/507 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGL--GLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKG 99
D+ + CS R LT +P+G+ G Q L+ NN + P + L +L L++ QL
Sbjct: 54 DELSVFCSSRNLTRLPDGVPGGTQALWLD-GNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 112
Query: 100 LPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQE 159
L AL L L L+L RN S L L PA L L LS N+ + + +
Sbjct: 113 LEPQALLGLENLCHLHLERNQLRS-LALG-TFAHTPA--LASLGLSNNRLSRLEDGLFEG 168
Query: 160 LLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISS---SLRSLF 216
L SL L L + ++ + GL ++R L L N L +Q + S LR L
Sbjct: 169 L---GSLWDLNLGWNSL-AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELD 224
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY---CNILQ 273
+S L ++ N + LP L L + N +A A L ++L+++D+S+ +L+
Sbjct: 225 LSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGA-FLGLKALRWLDLSHNRVAGLLE 283
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
G LR L+HN + L F + LE L L +N I L +F GL L+ L
Sbjct: 284 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 343
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL---------------------SRVGHLRS 372
L N++ + + L + ++ + LS N L S +G +R
Sbjct: 344 TLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRP 403
Query: 373 MSVTILD------MSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYL 424
+ T L + L I + SL GL ++ELDL+ N L+++P + L+YL
Sbjct: 404 HTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYL 463
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR-------------------RSFFD 465
L+ NR++ + L R L V NR + R+F
Sbjct: 464 LLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDF 492
P LERL L N W C C + +RDF
Sbjct: 524 QPPGLERLWLEGNPWDCGCPLKALRDF 550
Score = 83.8 bits (198), Expect = 2e-15
Identities = 77/271 (28%), Positives = 124/271 (45%), Gaps = 10/271 (3%)
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFA 301
NN ++ NL S + L+P L G +L L N +R L FA
Sbjct: 84 NNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFA 143
Query: 302 NNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR 361
+ L L LSNN ++ L F GL L L+L WN +AV+P+ + + SL +L L+
Sbjct: 144 HTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAG 203
Query: 362 N---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS--I 416
N YL + LD+S L I + L + +L L +NL++ + +
Sbjct: 204 NRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFL 263
Query: 417 SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
L++L+L++NR++ + TF L L L + N + R+F D + +LE L L
Sbjct: 264 GLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLH-FLEELQLG 322
Query: 477 DNMWR--CDCSDENMRDFYDFVTLEPNKKEE 505
N R + S E + + +TL+ N+ +E
Sbjct: 323 HNRIRQLAERSFEGLGQL-EVLTLDHNQLQE 352
>AF381545-1|AAK62357.1| 1093|Homo sapiens membrane glycoprotein
LRIG1 protein.
Length = 1093
Score = 100 bits (239), Expect = 2e-20
Identities = 97/353 (27%), Positives = 164/353 (46%), Gaps = 19/353 (5%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
L+LS+NK + ++L P+L+ + L++ E+ ++ S ++ L L N +
Sbjct: 73 LNLSYNKLSEIDPAGFEDL---PNLQEVYLNNNELTAVPSLGAASS--HVVSLFLQHNKI 127
Query: 202 LRIQNLISSSLRSLFVSNCEL---TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS 258
++ + SL V + L T + + P + L ++ N L A + S
Sbjct: 128 RSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS 187
Query: 259 QSLKYIDISYCNILQPNLKGF--PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+SL + +S I Q ++ F P L + LN N +R +E F LE L L NNI
Sbjct: 188 RSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSM 373
+ L F GL + L L +N + + SL + +L QL LS N ++R+ G
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
+ L +S L + ++SL L S+ L LS N +S+I + +L+ L+L++N I
Sbjct: 308 KLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI 367
Query: 432 SSINNLT---FFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWR 481
S T F L+ L+ L++ GN+ + +R+ F LE L+L N R
Sbjct: 368 SGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRA-FSGLEGLEHLNLGGNAIR 419
Score = 86.6 bits (205), Expect = 3e-16
Identities = 108/429 (25%), Positives = 185/429 (43%), Gaps = 41/429 (9%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C D +DC RGL +P L LN+S N+ ++ P L NL + +++N
Sbjct: 45 CTCAGDS--LDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNN 102
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+L +P + V++L + + + L L++LDLS N + N
Sbjct: 103 ELTAVPS---LGAASSHVVSLFLQH--NKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNT 157
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLI-NIRVLKLNFNPLLRIQNLISSSLRS 214
P ++ L L I ++ GL ++ L+L+ N RI L +R+
Sbjct: 158 CFPH---GPPIKELNLAGNRIGTLE-LGAFDGLSRSLLTLRLSKN---RITQL---PVRA 207
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQP 274
+ LN N + + LT +++ LE+ N S K D ++
Sbjct: 208 FKLPRLTQLDLNRNRIRLIEGLTFQGLNS---LEVLKLQRNNIS---KLTDGAFW----- 256
Query: 275 NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLD 334
G + L +N + + S + T L L LSNN+IA + + + L L
Sbjct: 257 ---GLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313
Query: 335 LSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKD 391
LS+N + + E+SL E+ SL+ L+LS N +S + G + + S+ +LD+ E++ +D
Sbjct: 314 LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
Query: 392 ---SLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRLT 446
+ GL S+ +L L N + + S L++LNL N I S+ F + L
Sbjct: 374 TSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLK 433
Query: 447 SLSVVGNRF 455
L + + F
Sbjct: 434 ELHISSDSF 442
>AB050468-1|BAB40659.1| 1094|Homo sapiens membrane glycoprotein
LIG-1 protein.
Length = 1094
Score = 100 bits (239), Expect = 2e-20
Identities = 97/353 (27%), Positives = 164/353 (46%), Gaps = 19/353 (5%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
L+LS+NK + ++L P+L+ + L++ E+ ++ S ++ L L N +
Sbjct: 73 LNLSYNKLSEIDPAGFEDL---PNLQEVYLNNNELTAVPSLGAASS--HVVSLFLQHNKI 127
Query: 202 LRIQNLISSSLRSLFVSNCEL---TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS 258
++ + SL V + L T + + P + L ++ N L A + S
Sbjct: 128 RSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS 187
Query: 259 QSLKYIDISYCNILQPNLKGF--PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+SL + +S I Q ++ F P L + LN N +R +E F LE L L NNI
Sbjct: 188 RSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSM 373
+ L F GL + L L +N + + SL + +L QL LS N ++R+ G
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
+ L +S L + ++SL L S+ L LS N +S+I + +L+ L+L++N I
Sbjct: 308 KLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI 367
Query: 432 SSINNLT---FFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWR 481
S T F L+ L+ L++ GN+ + +R+ F LE L+L N R
Sbjct: 368 SGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRA-FSGLEGLEHLNLGGNAIR 419
Score = 86.6 bits (205), Expect = 3e-16
Identities = 108/429 (25%), Positives = 185/429 (43%), Gaps = 41/429 (9%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C D +DC RGL +P L LN+S N+ ++ P L NL + +++N
Sbjct: 45 CTCAGDS--LDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNN 102
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+L +P + V++L + + + L L++LDLS N + N
Sbjct: 103 ELTAVPS---LGAASSHVVSLFLQH--NKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNT 157
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLI-NIRVLKLNFNPLLRIQNLISSSLRS 214
P ++ L L I ++ GL ++ L+L+ N RI L +R+
Sbjct: 158 CFPH---GPPIKELNLAGNRIGTLE-LGAFDGLSRSLLTLRLSKN---RITQL---PVRA 207
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQP 274
+ LN N + + LT +++ LE+ N S K D ++
Sbjct: 208 FKLPRLTQLDLNRNRIRLIEGLTFQGLNS---LEVLKLQRNNIS---KLTDGAFW----- 256
Query: 275 NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLD 334
G + L +N + + S + T L L LSNN+IA + + + L L
Sbjct: 257 ---GLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313
Query: 335 LSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKD 391
LS+N + + E+SL E+ SL+ L+LS N +S + G + + S+ +LD+ E++ +D
Sbjct: 314 LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
Query: 392 ---SLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRLT 446
+ GL S+ +L L N + + S L++LNL N I S+ F + L
Sbjct: 374 TSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLK 433
Query: 447 SLSVVGNRF 455
L + + F
Sbjct: 434 ELHISSDSF 442
>AY730707-1|AAU44786.1| 1093|Homo sapiens leucine-rich repeat
protein LRIG1 protein.
Length = 1093
Score = 99 bits (238), Expect = 3e-20
Identities = 96/360 (26%), Positives = 167/360 (46%), Gaps = 19/360 (5%)
Query: 138 HLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLN 197
+L+ ++LS+NK + ++L P+L+ + L++ E+ ++ S ++ L L
Sbjct: 93 NLQEVNLSYNKLSEIDPAGFEDL---PNLQEVYLNNNELTAVPSLGAASS--HVVSLFLQ 147
Query: 198 FNPLLRIQNLISSSLRSLFVSNCEL---TSLNHNELMFLPSLTHLKMSNNYRLELASSAN 254
N + ++ + SL V + L T + + P + L ++ N L A
Sbjct: 148 HNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAF 207
Query: 255 NLFSQSLKYIDISYCNILQPNLKGF--PSLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
+ S+SL + +S I Q ++ F P L + LN N +R +E F LE L L
Sbjct: 208 DGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQ 267
Query: 313 NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GH 369
NNI+ L F GL + L L +N + + SL + +L QL LS N ++R+ G
Sbjct: 268 RNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGW 327
Query: 370 LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLN 427
+ L +S L + ++SL L S+ L LS N +S+I + +L+ L+L+
Sbjct: 328 SFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLD 387
Query: 428 YNRISSINNLT---FFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
+N IS T F L+ L+ L++ GN + +F L+ L +S + + CDC
Sbjct: 388 HNEISGTIEDTSGAFSGLDSLSKLNLGGNAIRSVQFDAFVKMK-NLKELHISSDSFLCDC 446
Score = 94.7 bits (225), Expect = 1e-18
Identities = 105/404 (25%), Positives = 184/404 (45%), Gaps = 23/404 (5%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C D +DC RGL +P L LN+S N+ ++ P L NL +++S N
Sbjct: 45 CTCAGDS--LDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVNLSYN 102
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+L + +L L+ + L+ N + +L ++H+ L L NK +++
Sbjct: 103 KLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLG-----AASSHVVSLFLQHNKIRSVEGS 157
Query: 156 ANQELLIRPSLETLILDHCEI-NSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
+ L L+ + + E+ N+ P +N+ ++ L L S SL +
Sbjct: 158 QLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGL-SRSLLT 216
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQP 274
L +S +T L LP LT L ++ N R+ L SL+ + + NI +
Sbjct: 217 LRLSKNRITQLPVRAFK-LPRLTQLDLNRN-RIRLIEGLTFQGLNSLEVLKLQRNNISKL 274
Query: 275 NLKGFPSLRK---AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLK 331
F L K L +N + + S + T L L LSNN+IA + + + L
Sbjct: 275 TDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLH 334
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTI 388
L LS+N + + E+SL E+ SL+ L+LS N +S + G + + S+ +LD+ E++
Sbjct: 335 ELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGT 394
Query: 389 GKD---SLEGLQSIVELDLSQNLLSYIP-DS-ISSNTLKYLNLN 427
+D + GL S+ +L+L N + + D+ + LK L+++
Sbjct: 395 IEDTSGAFSGLDSLSKLNLGGNAIRSVQFDAFVKMKNLKELHIS 438
Score = 61.3 bits (142), Expect = 1e-08
Identities = 52/178 (29%), Positives = 94/178 (52%), Gaps = 7/178 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
L+LS N ++ + F L L+ ++LS+N+++ I ++P+L ++ L+ N L+ V
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVP 132
Query: 369 HLRSMS--VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYL 424
L + S V L + ++ ++ L+ S+ LDLS N ++ + ++ + +K L
Sbjct: 133 SLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKEL 192
Query: 425 NLNYNRISSINNLTFFMLNR-LTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWR 481
NL NRI ++ F L+R L +L + NR T + R+F P L +LDL+ N R
Sbjct: 193 NLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF--KLPRLTQLDLNRNRIR 248
Score = 39.1 bits (87), Expect = 0.057
Identities = 40/154 (25%), Positives = 75/154 (48%), Gaps = 8/154 (5%)
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSCELNT 387
+ L+LS+N+++ I ++P+L ++ LS N LS + G ++ + +++ EL
Sbjct: 71 RSLNLSYNKLSEIDPAGFEDLPNLQEVNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTA 130
Query: 388 IGKDSLEGLQS-IVELDLSQNLLSYIPDS--ISSNTLKYLNLNYNRISSINNLTFFMLNR 444
+ SL S +V L L N + + S + +L+ L+L+ N I+ + N F
Sbjct: 131 V--PSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPP 188
Query: 445 LTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
+ L++ GNR + +F + L L LS N
Sbjct: 189 IKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKN 222
>BC129927-1|AAI29928.1| 1323|Homo sapiens PH domain and leucine rich
repeat protein phosphatase-like protein.
Length = 1323
Score = 99.5 bits (237), Expect = 4e-20
Identities = 121/405 (29%), Positives = 186/405 (45%), Gaps = 41/405 (10%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T+++ S G D+P+ +G L + L + N T PE L L L +L IS N +P
Sbjct: 325 TELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIP 384
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM--GNLANQE 159
+ LT L+ + ++ N + LNL VL H+K +DL N +TM NL +
Sbjct: 385 E-VYEKLTMLDRVVMAGNCLEV-LNLG---VLNRMNHIKHVDLRMNHLKTMVIENLEGNK 439
Query: 160 LLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSN 219
+ L L + LS L ++ L N LR L SLR+L+ S+
Sbjct: 440 HITHVDLRDNRLTDLD---------LSSLCSLEQLHCGRNQ-LRELTLSGFSLRTLYASS 489
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQP---NL 276
LT++N + L LT L +S N LE ++ ++ +D+SY N+L +
Sbjct: 490 NRLTAVNVYPVPSL--LTFLDLSRNL-LECVPDW-ACEAKKIEVLDVSY-NLLTEVPVRI 544
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
SLRK +L HN V+ L + + LE LDL +N + L F L++L+ S
Sbjct: 545 LSSLSLRKLMLGHNHVQNLPT--LVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNAS 602
Query: 337 WNEIAVIPEDSLLE--MPSLTQLKLSRNYLS------RVGHLRSMSVTILDMSSCELNTI 388
N + +P E + L L L+ N L+ VGHL + IL +++ +L T
Sbjct: 603 ANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH---LRILHLANNQLQTF 659
Query: 389 GKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRIS 432
L L+ + EL+LS N L IP +I++ L L + N IS
Sbjct: 660 PASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNIS 704
Score = 64.1 bits (149), Expect = 2e-09
Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 16/262 (6%)
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
+++++ S L GL N+ KL P+L + S+L L +S C +++ L +
Sbjct: 292 LDTLYKFSQLKGL-NLSHNKLGLFPILLCE---ISTLTELNLS-CNGFHDLPSQIGNLLN 346
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNL-KGFPSLRKAILNHNMVR 293
L L + N+ L NL Q L + IS+ N Q P + + L + ++ N +
Sbjct: 347 LQTLCLDGNFLTTLPEELGNL--QQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLE 404
Query: 294 YLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPS 353
L ++++DL N++ ++ + G K + H+DL N + + SL S
Sbjct: 405 VLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLC---S 461
Query: 354 LTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
L QL RN L + L S+ L SS L + + L + LDLS+NLL +P
Sbjct: 462 LEQLHCGRNQLREL-TLSGFSLRTLYASSNRLTAVNVYPVPSL--LTFLDLSRNLLECVP 518
Query: 414 D-SISSNTLKYLNLNYNRISSI 434
D + + ++ L+++YN ++ +
Sbjct: 519 DWACEAKKIEVLDVSYNLLTEV 540
>BC096326-1|AAH96326.1| 883|Homo sapiens LGR5 protein protein.
Length = 883
Score = 99.1 bits (236), Expect = 5e-20
Identities = 90/322 (27%), Positives = 152/322 (47%), Gaps = 21/322 (6%)
Query: 53 LTDIPNGL--GLQVTK-LNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT IP G GL K L + NN+ P E+L L +L +L + +N + +P + L
Sbjct: 102 LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL 161
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
+L L L D+ L P + L+ + L+ NK + + A +L +
Sbjct: 162 HSLRHLWLD----DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFG------NLSS 211
Query: 169 LILDHCEINSIH--GRSPLSGLINIRVLKLNFNPLLRIQNLIS--SSLRSLFVSNCELTS 224
L++ H N IH G+ GL ++ L LN+N L I S+L+ L + +
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNPIQF 271
Query: 225 LNHNELMFLPSLTHLKMSNNYRL-ELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLR 283
+ + LP L L ++ ++ E +SL ++ Q P+L+
Sbjct: 272 VGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQ 331
Query: 284 KAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVI 343
L++N++ L S F+ +L+ +DL +N I ++ DTF+ L L+ L+L+WN+IA+I
Sbjct: 332 VLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII 389
Query: 344 PEDSLLEMPSLTQLKLSRNYLS 365
++ +PSL +L LS N LS
Sbjct: 390 HPNAFSTLPSLIKLDLSSNLLS 411
Score = 85.8 bits (203), Expect = 5e-16
Identities = 101/386 (26%), Positives = 165/386 (42%), Gaps = 18/386 (4%)
Query: 37 CRCNLDKT---DIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDI 92
C C D +DCS GL+++P+ L + + L++S N ++ P L L L L +
Sbjct: 38 CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRL 97
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM 152
+ N L +P A L +L+VL L N L P + L L+ L L N +
Sbjct: 98 AGNALTYIPKGAFTGLYSLKVLMLQNNQ----LRHVPTEALQNLRSLQSLRLDANHISYV 153
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
L SL L LD + I ++ L ++ + L N + I + +L
Sbjct: 154 PPSCFSGL---HSLRHLWLDDNALTEIPVQA-FRSLSALQAMTLALNKIHHIPDYAFGNL 209
Query: 213 RSLFV---SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISY 268
SL V N + SL L SL L ++ N E ++ L + + L + D
Sbjct: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNPI 269
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ + + P LR LN + E LE L L+ I+SL L
Sbjct: 270 QFVGRSAFQHLPELRTLTLN-GASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLP 328
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM-SVTILDMSSCELNT 387
L+ LDLS+N + +P S+ + L+ + Y +V + + S+ L+++ ++
Sbjct: 329 NLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI 388
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIP 413
I ++ L S+++LDLS NLLS P
Sbjct: 389 IHPNAFSTLPSLIKLDLSSNLLSSFP 414
Score = 79.0 bits (186), Expect = 6e-14
Identities = 93/348 (26%), Positives = 152/348 (43%), Gaps = 19/348 (5%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
LDLS N + L N +R LE L L + I + +GL +++VL L N L
Sbjct: 71 LDLSMNNISQL--LPNPLPSLR-FLEELRLAGNALTYIP-KGAFTGLYSLKVLMLQNNQL 126
Query: 202 LRIQNLISSSLRSLFVSNCELTSLNH---NELMFLPSLTHLKMSNNYRLELASSANNLFS 258
+ +LRSL + +++ + L SL HL + +N E+ A S
Sbjct: 127 RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS 186
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNH---NMVRYLESNAFANNTELEYLDLSNNN 315
+L+ + ++ I F +L ++ H N + L F LE LDL+ NN
Sbjct: 187 -ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNN 245
Query: 316 IASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSV 375
+ R L LK L N I + + +P L L L N S++ ++
Sbjct: 246 LDEFP-TAIRTLSNLKELHFYDNPIQFVGRSAFQHLPELRTLTL--NGASQITEFPDLTG 302
Query: 376 TI----LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRI 431
T L ++ +++++ + L ++ LDLS NLL +P L+ ++L +N I
Sbjct: 303 TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEI 362
Query: 432 SSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
I TF L L SL++ N+ +I + F + P L +LDLS N+
Sbjct: 363 YEIKVDTFQQLLSLRSLNLAWNKIAII-HPNAFSTLPSLIKLDLSSNL 409
Score = 76.2 bits (179), Expect = 4e-13
Identities = 65/241 (26%), Positives = 115/241 (47%), Gaps = 9/241 (3%)
Query: 218 SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLK 277
S+ L+ L N +F S L M+N +L + F + L+ + I +
Sbjct: 53 SDLGLSELPSNLSVFT-SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFT 111
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G SL+ +L +N +R++ + A N L+ L L N+I+ + F GL L+HL L
Sbjct: 112 GLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDD 171
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-----GHLRSMSVTILDMSSCELNTIGKDS 392
N + IP + + +L + L+ N + + G+L S+ +L + + ++++GK
Sbjct: 172 NALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL--VVLHLHNNRIHSLGKKC 229
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
+GL S+ LDL+ N L P +I + + LK L+ N I + F L L +L++
Sbjct: 230 FDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNPIQFVGRSAFQHLPELRTLTLN 289
Query: 452 G 452
G
Sbjct: 290 G 290
Score = 70.5 bits (165), Expect = 2e-11
Identities = 88/296 (29%), Positives = 135/296 (45%), Gaps = 26/296 (8%)
Query: 69 ISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL 127
+ +N T+ P ++ L L + ++ N++ +PD A NL++L VL+L N S L
Sbjct: 169 LDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHS-LGK 227
Query: 128 NPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH--GRSPL 185
D L L+ LDL++N NL IR +L L H N I GRS
Sbjct: 228 KCFDGL---HSLETLDLNYN------NLDEFPTAIR-TLSNLKELHFYDNPIQFVGRSAF 277
Query: 186 SGLINIRVLKLN-FNPLLRIQNLI-SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L +R L LN + + +L +++L SL ++ +++SL LP+L L +S
Sbjct: 278 QHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSY 337
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFP---SLRKAILNHNMVRYLESNAF 300
N +L S + Q L+ ID+ + I + + F SLR L N + + NAF
Sbjct: 338 NLLEDLPSFS---VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 394
Query: 301 ANNTELEYLDLSNNNIASLRYDTFRGLKMLK----HLDLSWNEIAVIPEDSLLEMP 352
+ L LDLS+N ++S GL LK H S PE ++EMP
Sbjct: 395 STLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMP 450
Score = 48.4 bits (110), Expect = 9e-05
Identities = 54/221 (24%), Positives = 96/221 (43%), Gaps = 27/221 (12%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNL---------- 116
L+++ N +FP ++ L NL L N ++ + +A +L L L L
Sbjct: 239 LDLNYNNLDEFPTAIRTLSNLKELHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFP 298
Query: 117 ---------SRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLE 167
S + ++ P V +L++LDLS+N + + + + + L+
Sbjct: 299 DLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFS-----VCQKLQ 353
Query: 168 TLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
+ L H EI I + L+++R L L +N + I S+L SL + L+
Sbjct: 354 KIDLRHNEIYEIKVDT-FQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSS 412
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
+ L LTHLK++ N+ L+ S+ N LK I++ Y
Sbjct: 413 FPITGLHGLTHLKLTGNHALQSLISSENF--PELKVIEMPY 451
>BC096325-1|AAH96325.1| 883|Homo sapiens LGR5 protein protein.
Length = 883
Score = 99.1 bits (236), Expect = 5e-20
Identities = 90/322 (27%), Positives = 152/322 (47%), Gaps = 21/322 (6%)
Query: 53 LTDIPNGL--GLQVTK-LNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT IP G GL K L + NN+ P E+L L +L +L + +N + +P + L
Sbjct: 102 LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL 161
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
+L L L D+ L P + L+ + L+ NK + + A +L +
Sbjct: 162 HSLRHLWLD----DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFG------NLSS 211
Query: 169 LILDHCEINSIH--GRSPLSGLINIRVLKLNFNPLLRIQNLIS--SSLRSLFVSNCELTS 224
L++ H N IH G+ GL ++ L LN+N L I S+L+ L + +
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNPIQF 271
Query: 225 LNHNELMFLPSLTHLKMSNNYRL-ELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLR 283
+ + LP L L ++ ++ E +SL ++ Q P+L+
Sbjct: 272 VGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQ 331
Query: 284 KAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVI 343
L++N++ L S F+ +L+ +DL +N I ++ DTF+ L L+ L+L+WN+IA+I
Sbjct: 332 VLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII 389
Query: 344 PEDSLLEMPSLTQLKLSRNYLS 365
++ +PSL +L LS N LS
Sbjct: 390 HPNAFSTLPSLIKLDLSSNLLS 411
Score = 85.8 bits (203), Expect = 5e-16
Identities = 101/386 (26%), Positives = 165/386 (42%), Gaps = 18/386 (4%)
Query: 37 CRCNLDKT---DIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDI 92
C C D +DCS GL+++P+ L + + L++S N ++ P L L L L +
Sbjct: 38 CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRL 97
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM 152
+ N L +P A L +L+VL L N L P + L L+ L L N +
Sbjct: 98 AGNALTYIPKGAFTGLYSLKVLMLQNNQ----LRHVPTEALQNLRSLQSLRLDANHISYV 153
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
L SL L LD + I ++ L ++ + L N + I + +L
Sbjct: 154 PPSCFSGL---HSLRHLWLDDNALTEIPVQA-FRSLSALQAMTLALNKIHHIPDYAFGNL 209
Query: 213 RSLFV---SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISY 268
SL V N + SL L SL L ++ N E ++ L + + L + D
Sbjct: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNPI 269
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ + + P LR LN + E LE L L+ I+SL L
Sbjct: 270 QFVGRSAFQHLPELRTLTLN-GASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLP 328
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM-SVTILDMSSCELNT 387
L+ LDLS+N + +P S+ + L+ + Y +V + + S+ L+++ ++
Sbjct: 329 NLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI 388
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIP 413
I ++ L S+++LDLS NLLS P
Sbjct: 389 IHPNAFSTLPSLIKLDLSSNLLSSFP 414
Score = 79.0 bits (186), Expect = 6e-14
Identities = 93/348 (26%), Positives = 152/348 (43%), Gaps = 19/348 (5%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
LDLS N + L N +R LE L L + I + +GL +++VL L N L
Sbjct: 71 LDLSMNNISQL--LPNPLPSLR-FLEELRLAGNALTYIP-KGAFTGLYSLKVLMLQNNQL 126
Query: 202 LRIQNLISSSLRSLFVSNCELTSLNH---NELMFLPSLTHLKMSNNYRLELASSANNLFS 258
+ +LRSL + +++ + L SL HL + +N E+ A S
Sbjct: 127 RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS 186
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNH---NMVRYLESNAFANNTELEYLDLSNNN 315
+L+ + ++ I F +L ++ H N + L F LE LDL+ NN
Sbjct: 187 -ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNN 245
Query: 316 IASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSV 375
+ R L LK L N I + + +P L L L N S++ ++
Sbjct: 246 LDEFP-TAIRTLSNLKELHFYDNPIQFVGRSAFQHLPELRTLTL--NGASQITEFPDLTG 302
Query: 376 TI----LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRI 431
T L ++ +++++ + L ++ LDLS NLL +P L+ ++L +N I
Sbjct: 303 TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEI 362
Query: 432 SSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
I TF L L SL++ N+ +I + F + P L +LDLS N+
Sbjct: 363 YEIKVDTFQQLLSLRSLNLAWNKIAII-HPNAFSTLPSLIKLDLSSNL 409
Score = 76.2 bits (179), Expect = 4e-13
Identities = 65/241 (26%), Positives = 115/241 (47%), Gaps = 9/241 (3%)
Query: 218 SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLK 277
S+ L+ L N +F S L M+N +L + F + L+ + I +
Sbjct: 53 SDLGLSELPSNLSVFT-SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFT 111
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G SL+ +L +N +R++ + A N L+ L L N+I+ + F GL L+HL L
Sbjct: 112 GLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDD 171
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-----GHLRSMSVTILDMSSCELNTIGKDS 392
N + IP + + +L + L+ N + + G+L S+ +L + + ++++GK
Sbjct: 172 NALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL--VVLHLHNNRIHSLGKKC 229
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
+GL S+ LDL+ N L P +I + + LK L+ N I + F L L +L++
Sbjct: 230 FDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELHFYDNPIQFVGRSAFQHLPELRTLTLN 289
Query: 452 G 452
G
Sbjct: 290 G 290
Score = 70.5 bits (165), Expect = 2e-11
Identities = 88/296 (29%), Positives = 135/296 (45%), Gaps = 26/296 (8%)
Query: 69 ISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL 127
+ +N T+ P ++ L L + ++ N++ +PD A NL++L VL+L N S L
Sbjct: 169 LDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHS-LGK 227
Query: 128 NPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH--GRSPL 185
D L L+ LDL++N NL IR +L L H N I GRS
Sbjct: 228 KCFDGL---HSLETLDLNYN------NLDEFPTAIR-TLSNLKELHFYDNPIQFVGRSAF 277
Query: 186 SGLINIRVLKLN-FNPLLRIQNLI-SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L +R L LN + + +L +++L SL ++ +++SL LP+L L +S
Sbjct: 278 QHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSY 337
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFP---SLRKAILNHNMVRYLESNAF 300
N +L S + Q L+ ID+ + I + + F SLR L N + + NAF
Sbjct: 338 NLLEDLPSFS---VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 394
Query: 301 ANNTELEYLDLSNNNIASLRYDTFRGLKMLK----HLDLSWNEIAVIPEDSLLEMP 352
+ L LDLS+N ++S GL LK H S PE ++EMP
Sbjct: 395 STLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMP 450
Score = 48.4 bits (110), Expect = 9e-05
Identities = 54/221 (24%), Positives = 96/221 (43%), Gaps = 27/221 (12%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNL---------- 116
L+++ N +FP ++ L NL L N ++ + +A +L L L L
Sbjct: 239 LDLNYNNLDEFPTAIRTLSNLKELHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFP 298
Query: 117 ---------SRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLE 167
S + ++ P V +L++LDLS+N + + + + + L+
Sbjct: 299 DLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFS-----VCQKLQ 353
Query: 168 TLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
+ L H EI I + L+++R L L +N + I S+L SL + L+
Sbjct: 354 KIDLRHNEIYEIKVDT-FQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSS 412
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
+ L LTHLK++ N+ L+ S+ N LK I++ Y
Sbjct: 413 FPITGLHGLTHLKLTGNHALQSLISSENF--PELKVIEMPY 451
>BC035267-1|AAH35267.1| 723|Homo sapiens PHLPPL protein protein.
Length = 723
Score = 99.1 bits (236), Expect = 5e-20
Identities = 121/405 (29%), Positives = 186/405 (45%), Gaps = 41/405 (10%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T+++ S G D+P+ +G L + L + N T PE L L L +L IS N +P
Sbjct: 63 TELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIP 122
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM--GNLANQE 159
+ LT L+ + ++ N + LNL VL H+K +DL N +TM NL +
Sbjct: 123 E-VYEKLTMLDRVVMAGNCLEV-LNLG---VLNRMNHIKHVDLRMNHLKTMVIENLEGNK 177
Query: 160 LLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSN 219
+ L L + LS L ++ L N LR L SLR+L+ S+
Sbjct: 178 HITHVDLRDNRLTDLD---------LSSLCSLEQLHCGRNQ-LRELTLSGFSLRTLYASS 227
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQP---NL 276
LT++N + L LT L +S N LE ++ ++ +D+SY N+L +
Sbjct: 228 NRLTAVNVYPVPSL--LTFLDLSRNL-LECVPDW-ACEAKKIEVLDVSY-NLLTEVPVRI 282
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
SLRK +L HN V+ L + + LE LDL +N + L F L++L+ S
Sbjct: 283 LSSLSLRKLMLGHNHVQNLPT--LVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNAS 340
Query: 337 WNEIAVIPEDSLLE--MPSLTQLKLSRNYLS------RVGHLRSMSVTILDMSSCELNTI 388
N + +P E + L L L+ N L+ VGHL + IL +++ +L T
Sbjct: 341 ANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH---LRILRLANNQLQTF 397
Query: 389 GKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRIS 432
L L+ + EL+LS N L IP +I++ L L + N IS
Sbjct: 398 PASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNIS 442
Score = 64.1 bits (149), Expect = 2e-09
Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 16/262 (6%)
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
+++++ S L GL N+ KL P+L + S+L L +S C +++ L +
Sbjct: 30 LDTLYKFSQLKGL-NLSHNKLGLFPILLCE---ISTLTELNLS-CNGFHDLPSQIGNLLN 84
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNL-KGFPSLRKAILNHNMVR 293
L L + N+ L NL Q L + IS+ N Q P + + L + ++ N +
Sbjct: 85 LQTLCLDGNFLTTLPEELGNL--QQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLE 142
Query: 294 YLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPS 353
L ++++DL N++ ++ + G K + H+DL N + + SL S
Sbjct: 143 VLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLC---S 199
Query: 354 LTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
L QL RN L + L S+ L SS L + + L + LDLS+NLL +P
Sbjct: 200 LEQLHCGRNQLREL-TLSGFSLRTLYASSNRLTAVNVYPVPSL--LTFLDLSRNLLECVP 256
Query: 414 D-SISSNTLKYLNLNYNRISSI 434
D + + ++ L+++YN ++ +
Sbjct: 257 DWACEAKKIEVLDVSYNLLTEV 278
>AF257182-1|AAF68989.1| 951|Homo sapiens G-protein-coupled receptor
48 protein.
Length = 951
Score = 98.3 bits (234), Expect = 9e-20
Identities = 114/426 (26%), Positives = 185/426 (43%), Gaps = 23/426 (5%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSN 95
C C+ D+ +DCS +GLT +P GL L+IS N T+ PE + L L ++ N
Sbjct: 33 CSCDGDRR-VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGN 91
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
L + AL L L+VL L N L P++ + + L+ L L N ++
Sbjct: 92 DLSFIHPKALSGLKELKVLTLQNNQ----LKTVPSEAIRGLSALQSLRLDANHITSVPED 147
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
+ + L+ L L LD + + PLS L ++ L L N + I + ++L SL
Sbjct: 148 SFEGLV---QLRHLWLDDNSLTEVPVH-PLSNLPTLQALTLALNKISSIPDFAFTNLSSL 203
Query: 216 FV---SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCNI 271
V N ++ L+ + L +L L +S N E + S + L + S I
Sbjct: 204 VVLHLHNNKIRGLSQHCFDGLDNLETLDLSYNNLGEFPQAIKARPSLKELGFHSNSISVI 263
Query: 272 LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLK 331
G P LR L N + ++ ++A N ++L L + ++ ++ G L+
Sbjct: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSASHNLSDLHSLVIRGASMVQ-QFPNLTGTVHLE 322
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM-SVTILDMSSCELNTIGK 390
L L+ +I+ IP + E L L LS N + + ++ + + ++ I +
Sbjct: 323 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKE 382
Query: 391 DSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFML---NRLTS 447
+ +GL S+ LDLS+NL+ I S L N S N LT F N L
Sbjct: 383 GTFQGLISLRILDLSRNLI----HEIHSRAFATLGPITNLDVSFNELTSFPTEGPNGLNQ 438
Query: 448 LSVVGN 453
L +VGN
Sbjct: 439 LKLVGN 444
Score = 93.9 bits (223), Expect = 2e-18
Identities = 92/309 (29%), Positives = 141/309 (45%), Gaps = 23/309 (7%)
Query: 62 LQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
+Q+ L + +N T+ P LS L L L ++ N++ +PD A NL++L VL+L N
Sbjct: 153 VQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNK 212
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
L+ + D L +L+ LDLS+N +G Q + RPSL+ L H S+
Sbjct: 213 IRG-LSQHCFDGL---DNLETLDLSYNN---LGEFP-QAIKARPSLKELGF-HSNSISVI 263
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLT 237
G +R + L NPL + N S S L SL + + N L
Sbjct: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSASHNLSDLHSLVIRGASMVQQFPN----LTGTV 319
Query: 238 HLKMSNNYRLELASSANNLFSQS--LKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRY 294
HL+ +++S NNL + L+ +D+SY NI P+ G +L + L N +
Sbjct: 320 HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQ 379
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
++ F L LDLS N I + F L + +LD+S+NE+ P + L
Sbjct: 380 IKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEG---PNGL 436
Query: 355 TQLKLSRNY 363
QLKL N+
Sbjct: 437 NQLKLVGNF 445
Score = 79.4 bits (187), Expect = 4e-14
Identities = 113/421 (26%), Positives = 192/421 (45%), Gaps = 45/421 (10%)
Query: 66 KLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+++ S T PE LS LDIS N + LP++A N LE L L+ N
Sbjct: 40 RVDCSGKGLTAVPEGLSAFTQA--LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF-- 95
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
++P L LK+L L N+ +T+ + A + L +L++L LD I S+ S
Sbjct: 96 -IHPK-ALSGLKELKVLTLQNNQLKTVPSEAIRGL---SALQSLRLDANHITSVPEDS-F 149
Query: 186 SGLINIRVLKLNFNPLLRIQ-NLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
GL+ +R L L+ N L + + +S+ +L++L ++ +++S+ L SL L +
Sbjct: 150 EGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLH 209
Query: 243 NNYRLELASSANNLFS--QSLKYIDISYCNILQ-PN-LKGFPSLRKAILNHNMVRYLESN 298
NN ++ + + F +L+ +D+SY N+ + P +K PSL++ + N + +
Sbjct: 210 NN---KIRGLSQHCFDGLDNLETLDLSYNNLGEFPQAIKARPSLKELGFHSNSISVIPDG 266
Query: 299 AFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM-PSLTQL 357
AF N L + L +N ++ + L L L VI S+++ P+LT
Sbjct: 267 AFDGNPLLRTIHLYDNPLSFVGNSASHNLSDLHSL--------VIRGASMVQQFPNLTGT 318
Query: 358 KLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSIS 417
HL S+++T +SS N + + + LDLS N + +P
Sbjct: 319 V----------HLESLTLTGTKISSIPNNLCQEQKM-----LRTLDLSYNNIRDLPSFNG 363
Query: 418 SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSD 477
+ L+ ++L N+I I TF L L L + N I R+F P + LD+S
Sbjct: 364 CHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP-ITNLDVSF 422
Query: 478 N 478
N
Sbjct: 423 N 423
Score = 71.7 bits (168), Expect = 9e-12
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 12/243 (4%)
Query: 264 IDISYCNILQ-PN--LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLR 320
+DIS NI Q P K FP L + L N + ++ A + EL+ L L NN + ++
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 321 YDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-HLRSMSVTI-- 377
+ RGL L+ L L N I +PEDS + L L L N L+ V H S T+
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQA 181
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSIN 435
L ++ ++++I + L S+V L L N + + + L+ L+L+YN +
Sbjct: 182 LTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRGLSQHCFDGLDNLETLDLSYNNLGEFP 241
Query: 436 NLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN--MWRCDCSDENMRDFY 493
L L N ++I FD NP L + L DN + + + N+ D +
Sbjct: 242 Q-AIKARPSLKELGFHSNSISVI-PDGAFDGNPLLRTIHLYDNPLSFVGNSASHNLSDLH 299
Query: 494 DFV 496
V
Sbjct: 300 SLV 302
>Z24680-1|CAA80847.1| 662|Homo sapiens garp protein.
Length = 662
Score = 94.7 bits (225), Expect = 1e-18
Identities = 129/464 (27%), Positives = 196/464 (42%), Gaps = 37/464 (7%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQL 97
C + + C GL +P+ L L++S N+ S L L +LD+S+N++
Sbjct: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLAN 157
L A LT LE L+L+ N L+ L P + LDLS N + L
Sbjct: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGG-LGPLPRVTSLDLSGNSLYS--GLLE 142
Query: 158 QELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFV 217
+ L PSL TL L + + R + + L L+ N L+ I++ L L
Sbjct: 143 RLLGEAPSLHTLSLAENSLTRLT-RHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTH 201
Query: 218 SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNL 276
N SL L L L +S N +++ L ++D+ +L P+L
Sbjct: 202 LNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDL 261
Query: 277 KGFPSLRKAILNHNMVRYL------ESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L L++N++R A + L LS A + R L L
Sbjct: 262 AALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLS----APSGNASGRPLSQL 317
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL-----SRVGHLRSMSVTILDMSSCEL 385
+LDLS+NEI +IP+ L + SL L LSRN L R+G L + + L ++ E
Sbjct: 318 LNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALET 377
Query: 386 NTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINN------- 436
+G +L L++++ L N L +P +N +L+ LNL NR+S
Sbjct: 378 LELGARALGSLRTLL---LQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPS 434
Query: 437 --LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
+ F + L SLS+V N ++ R F P L LDLS N
Sbjct: 435 GCVAFSGITSLRSLSLVDNEIELL-RAGAFLHTP-LTELDLSSN 476
Score = 68.5 bits (160), Expect = 8e-11
Identities = 82/273 (30%), Positives = 132/273 (48%), Gaps = 27/273 (9%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILD 143
L L+NLD+S N+++ +PD+ L +LT+L LNLSRN ++ LP L +LD
Sbjct: 314 LSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGS--LPC--LMLLD 369
Query: 144 LSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN---- 199
LS N +T+ L + L SL TL+L + + + + L +++ L L N
Sbjct: 370 LSHNALETL-ELGARAL---GSLRTLLLQGNALRDLPPYT-FANLASLQRLNLQGNRVSP 424
Query: 200 --------PLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELAS 251
P + +SLRSL + + E+ L + P LT L +S+N LE+A+
Sbjct: 425 CGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVAT 483
Query: 252 SANNLFSQSLKYIDI--SYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
A SL+ + + + +LQ +L F L++ L N + +L A+ LE L
Sbjct: 484 GALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVL 541
Query: 310 DLSNNNIASLRYDTFRGLK-MLKHLDLSWNEIA 341
DL NN+ + L GL+ L+ L L N ++
Sbjct: 542 DLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLS 574
Score = 55.6 bits (128), Expect = 6e-07
Identities = 100/370 (27%), Positives = 157/370 (42%), Gaps = 37/370 (10%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILD 143
L L +L++S N L + D ++L L VL+LS N +++ + T L D
Sbjct: 196 LPRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWL---D 249
Query: 144 LSFNKFQTMGNLANQELLIRPSLETLIL-----DHCEINSIHGRSPLSGLINIRVLKLNF 198
L NK +LA LI +L ++ + IH +P G L L+
Sbjct: 250 LRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIH--APSEGW---SALPLSA 304
Query: 199 NPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN-YRLELASSANNLF 257
P S L +L +S E+ + + L L SL L +S N R A +L
Sbjct: 305 -PSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSL- 362
Query: 258 SQSLKYIDISY--CNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNN 315
L +D+S+ L+ + SLR +L N +R L FAN L+ L+L N
Sbjct: 363 -PCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNR 421
Query: 316 IASLRYD---------TFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR 366
++ F G+ L+ L L NEI ++ + L P LT+L LS N
Sbjct: 422 VSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLE 480
Query: 367 V--GHLRSM--SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLK 422
V G L + S+ +L + L + D L + L+L++N LS++P + +L+
Sbjct: 481 VATGALGGLEASLEVLALQGNGLMVLQVD-LPCFICLKRLNLAENRLSHLPAWTQAVSLE 539
Query: 423 YLNLNYNRIS 432
L+L N S
Sbjct: 540 VLDLRNNSFS 549
>BC070079-1|AAH70079.1| 662|Homo sapiens LRRC32 protein protein.
Length = 662
Score = 94.7 bits (225), Expect = 1e-18
Identities = 129/464 (27%), Positives = 196/464 (42%), Gaps = 37/464 (7%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQL 97
C + + C GL +P+ L L++S N+ S L L +LD+S+N++
Sbjct: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLAN 157
L A LT LE L+L+ N L+ L P + LDLS N + L
Sbjct: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGG-LGPLPRVTSLDLSGNSLYS--GLLE 142
Query: 158 QELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFV 217
+ L PSL TL L + + R + + L L+ N L+ I++ L L
Sbjct: 143 RLLGEAPSLHTLSLAENSLTRLT-RHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTH 201
Query: 218 SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNL 276
N SL L L L +S N +++ L ++D+ +L P+L
Sbjct: 202 LNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDL 261
Query: 277 KGFPSLRKAILNHNMVRYL------ESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L L++N++R A + L LS A + R L L
Sbjct: 262 AALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLS----APSGNASGRPLSQL 317
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL-----SRVGHLRSMSVTILDMSSCEL 385
+LDLS+NEI +IP+ L + SL L LSRN L R+G L + + L ++ E
Sbjct: 318 LNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALET 377
Query: 386 NTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINN------- 436
+G +L L++++ L N L +P +N +L+ LNL NR+S
Sbjct: 378 LELGARALGSLRTLL---LQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPS 434
Query: 437 --LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
+ F + L SLS+V N ++ R F P L LDLS N
Sbjct: 435 GCVAFSGITSLRSLSLVDNEIELL-RAGAFLHTP-LTELDLSSN 476
Score = 68.5 bits (160), Expect = 8e-11
Identities = 82/273 (30%), Positives = 132/273 (48%), Gaps = 27/273 (9%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILD 143
L L+NLD+S N+++ +PD+ L +LT+L LNLSRN ++ LP L +LD
Sbjct: 314 LSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGS--LPC--LMLLD 369
Query: 144 LSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN---- 199
LS N +T+ L + L SL TL+L + + + + L +++ L L N
Sbjct: 370 LSHNALETL-ELGARAL---GSLRTLLLQGNALRDLPPYT-FANLASLQRLNLQGNRVSP 424
Query: 200 --------PLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELAS 251
P + +SLRSL + + E+ L + P LT L +S+N LE+A+
Sbjct: 425 CGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVAT 483
Query: 252 SANNLFSQSLKYIDI--SYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
A SL+ + + + +LQ +L F L++ L N + +L A+ LE L
Sbjct: 484 GALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVL 541
Query: 310 DLSNNNIASLRYDTFRGLK-MLKHLDLSWNEIA 341
DL NN+ + L GL+ L+ L L N ++
Sbjct: 542 DLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLS 574
Score = 55.6 bits (128), Expect = 6e-07
Identities = 100/370 (27%), Positives = 157/370 (42%), Gaps = 37/370 (10%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILD 143
L L +L++S N L + D ++L L VL+LS N +++ + T L D
Sbjct: 196 LPRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWL---D 249
Query: 144 LSFNKFQTMGNLANQELLIRPSLETLIL-----DHCEINSIHGRSPLSGLINIRVLKLNF 198
L NK +LA LI +L ++ + IH +P G L L+
Sbjct: 250 LRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIH--APSEGW---SALPLSA 304
Query: 199 NPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN-YRLELASSANNLF 257
P S L +L +S E+ + + L L SL L +S N R A +L
Sbjct: 305 -PSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSL- 362
Query: 258 SQSLKYIDISY--CNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNN 315
L +D+S+ L+ + SLR +L N +R L FAN L+ L+L N
Sbjct: 363 -PCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNR 421
Query: 316 IASLRYD---------TFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR 366
++ F G+ L+ L L NEI ++ + L P LT+L LS N
Sbjct: 422 VSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLE 480
Query: 367 V--GHLRSM--SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLK 422
V G L + S+ +L + L + D L + L+L++N LS++P + +L+
Sbjct: 481 VATGALGGLEASLEVLALQGNGLMVLQVD-LPCFICLKRLNLAENRLSHLPAWTQAVSLE 539
Query: 423 YLNLNYNRIS 432
L+L N S
Sbjct: 540 VLDLRNNSFS 549
>BC036337-1|AAH36337.1| 811|Homo sapiens KIAA0644 gene product
protein.
Length = 811
Score = 93.9 bits (223), Expect = 2e-18
Identities = 87/288 (30%), Positives = 135/288 (46%), Gaps = 22/288 (7%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCN- 270
LR L + ++ SL+ L L L + NN LA L+ + I Y N
Sbjct: 85 LRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGT----LAPLRKLRILYANG 140
Query: 271 -----ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+ + + +G SL K L+ N + L FA L YL L +N I L + F
Sbjct: 141 NEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFA 200
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMP--SLTQLKLSRNYLSRVG-----HLRSMSVTIL 378
L L+ L+LS NE+ + P SL+ L LS N L +G HL + +L
Sbjct: 201 QLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANSLQHLGPRIFQHLPRLG--LL 258
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYNRISSINN 436
+ +L + ++ GL+++ EL L N LS +P ++ ++L+ L+L+ N +S+++
Sbjct: 259 SLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHP 318
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
TF L RL LS+ N + + F ++P L RLDL N W CDC
Sbjct: 319 ATFGHLGRLRELSLRNNALSAL-SGDIFAASPALYRLDLDGNGWTCDC 365
Score = 55.2 bits (127), Expect = 8e-07
Identities = 89/323 (27%), Positives = 132/323 (40%), Gaps = 30/323 (9%)
Query: 48 CSRRGLTDIPNGLGL----QVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPD 102
C+ RGL +P L V ++ N T RL L LD+ NQ++ L
Sbjct: 41 CTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHP 100
Query: 103 NALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLI 162
L+ LE L L N + L P L P L+IL + N+ + + + L
Sbjct: 101 KTFEKLSRLEELYLGNNLLQA---LAPG-TLAPLRKLRILYANGNEISRLSRGSFEGL-- 154
Query: 163 RPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCEL 222
SL L LD + ++ + + L N+ L L N RI+ L ++ L
Sbjct: 155 -ESLVKLRLDGNALGALPD-AVFAPLGNLLYLHLESN---RIRFLGKNAFAQL--GKLRF 207
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSL 282
+L+ NEL PSL H R + S+ L + SL+++ L P L G SL
Sbjct: 208 LNLSANELQ--PSLRHAATFAPLR---SLSSLILSANSLQHLGPRIFQHL-PRL-GLLSL 260
Query: 283 RKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAV 342
R N + +L AF L L L N ++ L L L+ LDLS NE++
Sbjct: 261 RG-----NQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSA 315
Query: 343 IPEDSLLEMPSLTQLKLSRNYLS 365
+ + + L +L L N LS
Sbjct: 316 LHPATFGHLGRLRELSLRNNALS 338
Score = 52.4 bits (120), Expect = 6e-06
Identities = 48/169 (28%), Positives = 73/169 (43%), Gaps = 23/169 (13%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N + + + F +L LDL N I SL TF L L+ L L N + +
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 347 SLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQ 406
+L + L L + N +SR + + S EGL+S+V+L L
Sbjct: 126 TLAPLRKLRILYANGNEISR---------------------LSRGSFEGLESLVKLRLDG 164
Query: 407 NLLSYIPDSISS--NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
N L +PD++ + L YL+L NRI + F L +L L++ N
Sbjct: 165 NALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSAN 213
>AB014544-1|BAA31619.2| 887|Homo sapiens KIAA0644 protein protein.
Length = 887
Score = 93.9 bits (223), Expect = 2e-18
Identities = 87/288 (30%), Positives = 135/288 (46%), Gaps = 22/288 (7%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCN- 270
LR L + ++ SL+ L L L + NN LA L+ + I Y N
Sbjct: 161 LRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGT----LAPLRKLRILYANG 216
Query: 271 -----ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+ + + +G SL K L+ N + L FA L YL L +N I L + F
Sbjct: 217 NEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFA 276
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMP--SLTQLKLSRNYLSRVG-----HLRSMSVTIL 378
L L+ L+LS NE+ + P SL+ L LS N L +G HL + +L
Sbjct: 277 QLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANSLQHLGPRIFQHLPRLG--LL 334
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYNRISSINN 436
+ +L + ++ GL+++ EL L N LS +P ++ ++L+ L+L+ N +S+++
Sbjct: 335 SLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHP 394
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
TF L RL LS+ N + + F ++P L RLDL N W CDC
Sbjct: 395 ATFGHLGRLRELSLRNNALSAL-SGDIFAASPALYRLDLDGNGWTCDC 441
Score = 55.2 bits (127), Expect = 8e-07
Identities = 89/323 (27%), Positives = 132/323 (40%), Gaps = 30/323 (9%)
Query: 48 CSRRGLTDIPNGLGL----QVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPD 102
C+ RGL +P L V ++ N T RL L LD+ NQ++ L
Sbjct: 117 CTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHP 176
Query: 103 NALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLI 162
L+ LE L L N + L P L P L+IL + N+ + + + L
Sbjct: 177 KTFEKLSRLEELYLGNNLLQA---LAPG-TLAPLRKLRILYANGNEISRLSRGSFEGL-- 230
Query: 163 RPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCEL 222
SL L LD + ++ + + L N+ L L N RI+ L ++ L
Sbjct: 231 -ESLVKLRLDGNALGALPD-AVFAPLGNLLYLHLESN---RIRFLGKNAFAQL--GKLRF 283
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSL 282
+L+ NEL PSL H R + S+ L + SL+++ L P L G SL
Sbjct: 284 LNLSANELQ--PSLRHAATFAPLR---SLSSLILSANSLQHLGPRIFQHL-PRL-GLLSL 336
Query: 283 RKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAV 342
R N + +L AF L L L N ++ L L L+ LDLS NE++
Sbjct: 337 RG-----NQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSA 391
Query: 343 IPEDSLLEMPSLTQLKLSRNYLS 365
+ + + L +L L N LS
Sbjct: 392 LHPATFGHLGRLRELSLRNNALS 414
Score = 52.4 bits (120), Expect = 6e-06
Identities = 48/169 (28%), Positives = 73/169 (43%), Gaps = 23/169 (13%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N + + + F +L LDL N I SL TF L L+ L L N + +
Sbjct: 142 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 201
Query: 347 SLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQ 406
+L + L L + N +SR + + S EGL+S+V+L L
Sbjct: 202 TLAPLRKLRILYANGNEISR---------------------LSRGSFEGLESLVKLRLDG 240
Query: 407 NLLSYIPDSISS--NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
N L +PD++ + L YL+L NRI + F L +L L++ N
Sbjct: 241 NALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSAN 289
>BC101065-1|AAI01066.1| 581|Homo sapiens LRRC15 protein protein.
Length = 581
Score = 93.1 bits (221), Expect = 3e-18
Identities = 116/443 (26%), Positives = 190/443 (42%), Gaps = 40/443 (9%)
Query: 86 NLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLS 145
N ++L I + + L ++ N++AL L + +N + P L+ L L+
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELS---RITPG-AFRNLGSLRYLSLA 109
Query: 146 FNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
NK Q + Q L SLE+L+L ++ I + S N++ L+L+ N L I
Sbjct: 110 NNKLQVLPIGLFQGL---DSLESLLLSSNQLLQIQP-AHFSQCSNLKELQLHGNHLEYIP 165
Query: 206 NLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYID 265
+ F LT LN + SLTH+ + NL Q L+ +
Sbjct: 166 D-------GAFDHLVGLTKLNLGK----NSLTHISP------RVFQHLGNL--QVLRLYE 206
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+I G +L++ L N + L F NN L+ L LSNN+I+ L F
Sbjct: 207 NRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFM 266
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-----GHLRSMSVTILDM 380
L L L L N + + MP+L +L L N++S + +LR + V IL
Sbjct: 267 QLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL-- 324
Query: 381 SSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLT 438
S +++ I + GL + EL L N L + ++ L+ ++L NR+ +
Sbjct: 325 SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNI 384
Query: 439 FFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTL 498
F +N L ++ + N+ + FD L L L DN WRCD +R++ +
Sbjct: 385 FANVNGLMAIQLQNNQLENL-PLGIFDHLGKLCELRLYDNPWRCDSDILPLRNW--LLLN 441
Query: 499 EPNKKEESFNLICNSPANVNTQT 521
+P ++ +C SPANV Q+
Sbjct: 442 QPRLGTDTVP-VCFSPANVRGQS 463
Score = 65.3 bits (152), Expect = 8e-10
Identities = 82/321 (25%), Positives = 136/321 (42%), Gaps = 41/321 (12%)
Query: 56 IPNGL--GLQ-VTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTAL 111
+P GL GL + L +S+N+ + P S+ NL L + N L+ +PD A +L L
Sbjct: 116 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 175
Query: 112 EVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLIL 171
LNL +N TH +S FQ +GN L+ L L
Sbjct: 176 TKLNLGKN---------------SLTH-----ISPRVFQHLGN-----------LQVLRL 204
Query: 172 DHCEINSIHGRSPLSGLINIRVLKLNFNPL-LRIQNLI--SSSLRSLFVSNCELTSLNHN 228
+ I GL+N++ L L N + L L + +L+ L++SN ++ L +
Sbjct: 205 YENRLTDI-PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263
Query: 229 ELMFLPSLTHLKMSNNYRLELASSANNLFSQSLK-YIDISYCNILQPNL-KGFPSLRKAI 286
M LP L L + N EL+ + ++ ++ + L N+ L+ I
Sbjct: 264 VFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLI 323
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N + ++ AF TEL L L N + L + FR L L+++ L N + +P +
Sbjct: 324 LSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGN 383
Query: 347 SLLEMPSLTQLKLSRNYLSRV 367
+ L ++L N L +
Sbjct: 384 IFANVNGLMAIQLQNNQLENL 404
Score = 40.3 bits (90), Expect = 0.024
Identities = 35/121 (28%), Positives = 55/121 (45%), Gaps = 10/121 (8%)
Query: 49 SRRGLTDIPNGLGLQVTKLN---ISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNA 104
S ++ +P + +Q+ +LN + N + P + NL L + N + LPDN
Sbjct: 253 SNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNV 312
Query: 105 LYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK-----ILDLSFNKFQTMGNLANQE 159
NL L+VL LSRN S+++ + L L + DL N F+ + NL N
Sbjct: 313 FSNLRQLQVLILSRNQI-SFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNIS 371
Query: 160 L 160
L
Sbjct: 372 L 372
>BC101064-1|AAI01065.1| 581|Homo sapiens leucine rich repeat
containing 15 protein.
Length = 581
Score = 93.1 bits (221), Expect = 3e-18
Identities = 116/443 (26%), Positives = 190/443 (42%), Gaps = 40/443 (9%)
Query: 86 NLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLS 145
N ++L I + + L ++ N++AL L + +N + P L+ L L+
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELS---RITPG-AFRNLGSLRYLSLA 109
Query: 146 FNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
NK Q + Q L SLE+L+L ++ I + S N++ L+L+ N L I
Sbjct: 110 NNKLQVLPIGLFQGL---DSLESLLLSSNQLLQIQP-AHFSQCSNLKELQLHGNHLEYIP 165
Query: 206 NLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYID 265
+ F LT LN + SLTH+ + NL Q L+ +
Sbjct: 166 D-------GAFDHLVGLTKLNLGK----NSLTHISP------RVFQHLGNL--QVLRLYE 206
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+I G +L++ L N + L F NN L+ L LSNN+I+ L F
Sbjct: 207 NRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFM 266
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-----GHLRSMSVTILDM 380
L L L L N + + MP+L +L L N++S + +LR + V IL
Sbjct: 267 QLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL-- 324
Query: 381 SSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLT 438
S +++ I + GL + EL L N L + ++ L+ ++L NR+ +
Sbjct: 325 SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNI 384
Query: 439 FFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTL 498
F +N L ++ + N+ + FD L L L DN WRCD +R++ +
Sbjct: 385 FANVNGLMAIQLQNNQLENL-PLGIFDHLGKLCELRLYDNPWRCDSDILPLRNW--LLLN 441
Query: 499 EPNKKEESFNLICNSPANVNTQT 521
+P ++ +C SPANV Q+
Sbjct: 442 QPRLGTDTVP-VCFSPANVRGQS 463
Score = 65.3 bits (152), Expect = 8e-10
Identities = 82/321 (25%), Positives = 136/321 (42%), Gaps = 41/321 (12%)
Query: 56 IPNGL--GLQ-VTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTAL 111
+P GL GL + L +S+N+ + P S+ NL L + N L+ +PD A +L L
Sbjct: 116 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 175
Query: 112 EVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLIL 171
LNL +N TH +S FQ +GN L+ L L
Sbjct: 176 TKLNLGKN---------------SLTH-----ISPRVFQHLGN-----------LQVLRL 204
Query: 172 DHCEINSIHGRSPLSGLINIRVLKLNFNPL-LRIQNLI--SSSLRSLFVSNCELTSLNHN 228
+ I GL+N++ L L N + L L + +L+ L++SN ++ L +
Sbjct: 205 YENRLTDI-PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263
Query: 229 ELMFLPSLTHLKMSNNYRLELASSANNLFSQSLK-YIDISYCNILQPNL-KGFPSLRKAI 286
M LP L L + N EL+ + ++ ++ + L N+ L+ I
Sbjct: 264 VFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLI 323
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N + ++ AF TEL L L N + L + FR L L+++ L N + +P +
Sbjct: 324 LSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGN 383
Query: 347 SLLEMPSLTQLKLSRNYLSRV 367
+ L ++L N L +
Sbjct: 384 IFANVNGLMAIQLQNNQLENL 404
Score = 40.3 bits (90), Expect = 0.024
Identities = 35/121 (28%), Positives = 55/121 (45%), Gaps = 10/121 (8%)
Query: 49 SRRGLTDIPNGLGLQVTKLN---ISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNA 104
S ++ +P + +Q+ +LN + N + P + NL L + N + LPDN
Sbjct: 253 SNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNV 312
Query: 105 LYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK-----ILDLSFNKFQTMGNLANQE 159
NL L+VL LSRN S+++ + L L + DL N F+ + NL N
Sbjct: 313 FSNLRQLQVLILSRNQI-SFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNIS 371
Query: 160 L 160
L
Sbjct: 372 L 372
>BC071561-1|AAH71561.1| 1070|Homo sapiens LRIG1 protein protein.
Length = 1070
Score = 93.1 bits (221), Expect = 3e-18
Identities = 88/318 (27%), Positives = 147/318 (46%), Gaps = 15/318 (4%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
L+LS+NKF + ++L P+L+ + L++ E+ ++ S ++ L L N +
Sbjct: 73 LNLSYNKFSEIDPAGFEDL---PNLQEVYLNNNELTAVPSLGAASS--HVVSLFLQHNKI 127
Query: 202 LRIQNLISSSLRSLFVSNCEL---TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS 258
++ + SL V + L T + + P + L ++ N L A + S
Sbjct: 128 RSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS 187
Query: 259 QSLKYIDISYCNILQPNLKGF--PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+SL + +S I Q ++ F P L + LN N +R +E F LE L L NNI
Sbjct: 188 RSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSM 373
+ L F GL + L L +N + + SL + +L QL LS N ++R+ G
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
+ L +S L + ++SL L S+ L LS N +S+I + +L+ L+L++N I
Sbjct: 308 KLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI 367
Query: 432 SSINNLTFFMLNRLTSLS 449
S T + L SLS
Sbjct: 368 SGTIEDTSGAFSGLDSLS 385
Score = 86.6 bits (205), Expect = 3e-16
Identities = 116/458 (25%), Positives = 197/458 (43%), Gaps = 42/458 (9%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C D +DC RGL +P L LN+S N+F++ P L NL + +++N
Sbjct: 45 CTCAGDS--LDCGGRGLAALPGDLPSWTRSLNLSYNKFSEIDPAGFEDLPNLQEVYLNNN 102
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+L +P + V++L + + + L L++LDLS N + N
Sbjct: 103 ELTAVPS---LGAASSHVVSLFLQH--NKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNT 157
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLI-NIRVLKLNFNPLLRIQNLISSSLRS 214
P ++ L L I ++ GL ++ L+L+ N RI L +R+
Sbjct: 158 CFPH---GPPIKELNLAGNRIGTLE-LGAFDGLSRSLLTLRLSKN---RITQL---PVRA 207
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQP 274
+ LN N + + LT +++ LE+ N S K D ++
Sbjct: 208 FKLPRLTQLDLNRNRIRLIEGLTFQGLNS---LEVLKLQRNNIS---KLTDGAFW----- 256
Query: 275 NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLD 334
G + L +N + + S + T L L LSNN+IA + + + L L
Sbjct: 257 ---GLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELV 313
Query: 335 LSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKD 391
LS+N + + E+SL E+ SL+ L+LS N +S + G + + S+ +LD+ E++ +D
Sbjct: 314 LSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
Query: 392 ---SLEGLQSIVELDLSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLT 446
+ GL S+ +L L + S S S + L N+I S+ F L L
Sbjct: 374 TSGAFSGLDSLSKLLLLEPSQSAGCSSPSQPHMSAGGRTLFGNKIKSVAKRAFSGLEGLE 433
Query: 447 SLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
L++ GN + +F L+ L +S + + CDC
Sbjct: 434 HLNLGGNAIRSVQFDAFVKMK-NLKELHISSDSFLCDC 470
>AB071037-1|BAB84587.1| 581|Homo sapiens Lib protein.
Length = 581
Score = 91.9 bits (218), Expect = 8e-18
Identities = 116/443 (26%), Positives = 190/443 (42%), Gaps = 40/443 (9%)
Query: 86 NLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLS 145
N ++L I + + L ++ N++AL L + +N + P L+ L L+
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELS---RITPG-AFRNLGSLRYLSLA 109
Query: 146 FNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
NK Q + Q L SLE+L+L ++ I + S N++ L+L+ N L I
Sbjct: 110 NNKLQVLPIGLFQGL---DSLESLLLSSNQLLQIQP-AHFSQCSNLKELQLHGNHLEYIP 165
Query: 206 NLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYID 265
+ F LT LN + SLTH+ + NL Q L+ +
Sbjct: 166 D-------GAFDHLVGLTKLNLGK----NSLTHISP------RVFQHLGNL--QVLRLYE 206
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+I G +L++ L N + L F NN L+ L LSNN+I+ L F
Sbjct: 207 NRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFM 266
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-----GHLRSMSVTILDM 380
L L L L N + + MP+L +L L N++S + +LR + V IL
Sbjct: 267 QLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL-- 324
Query: 381 SSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLT 438
S +++ I + GL + EL L N L + ++ L+ ++L NR+ +
Sbjct: 325 SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNI 384
Query: 439 FFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTL 498
F +N L ++ + N+ + FD L L L DN WRCD +R++ +
Sbjct: 385 FANVNGLMAIQLQNNQLENL-PLGIFDHLGKLCELRLYDNPWRCDSDILPLRNW--LLLN 441
Query: 499 EPNKKEESFNLICNSPANVNTQT 521
+P ++ +C SPANV Q+
Sbjct: 442 QPRLGTDTVP-VCFSPANVRGQS 463
Score = 64.5 bits (150), Expect = 1e-09
Identities = 82/321 (25%), Positives = 136/321 (42%), Gaps = 41/321 (12%)
Query: 56 IPNGL--GLQ-VTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTAL 111
+P GL GL + L +S+N+ + P S+ NL L + N L+ +PD A +L L
Sbjct: 116 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 175
Query: 112 EVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLIL 171
LNL +N TH +S FQ +GN L+ L L
Sbjct: 176 TKLNLGKN---------------SLTH-----ISPRVFQHLGN-----------LQVLRL 204
Query: 172 DHCEINSIHGRSPLSGLINIRVLKLNFNPL-LRIQNLI--SSSLRSLFVSNCELTSLNHN 228
+ I GL+N++ L L N + L L + +L+ L++SN ++ L +
Sbjct: 205 YENRLTDI-PMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263
Query: 229 ELMFLPSLTHLKMSNNYRLELASSANNLFSQSLK-YIDISYCNILQPNL-KGFPSLRKAI 286
M LP L L + N EL+ + ++ ++ + L N+ L+ I
Sbjct: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLI 323
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N + ++ AF TEL L L N + L + FR L L+++ L N + +P +
Sbjct: 324 LSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGN 383
Query: 347 SLLEMPSLTQLKLSRNYLSRV 367
+ L ++L N L +
Sbjct: 384 IFANVNGLMAIQLQNNQLENL 404
>AY358733-1|AAQ89095.1| 622|Homo sapiens CGLQ1891 protein.
Length = 622
Score = 91.5 bits (217), Expect = 1e-17
Identities = 81/280 (28%), Positives = 136/280 (48%), Gaps = 17/280 (6%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHL---KMSNNYRLELASSANNLFSQSLKYI---- 264
LR V C L L H E++ S+ L + N L L+S N F +S ++
Sbjct: 11 LRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKN-FPESTVFLYLTG 69
Query: 265 -DISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+ISY N + L G SL L+++ + Y+ AF L +L L+NN I L
Sbjct: 70 NNISYIN--ESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGI 127
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDM 380
F+GL L++L L +N+++ +P ++ S+ L L RN L+ +G + +++ ILD+
Sbjct: 128 FKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDL 187
Query: 381 SSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYNRISSINNLT 438
S+ + I + + L+++ L L N L+ +P + +L+ L+L++N I +I
Sbjct: 188 SNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA 247
Query: 439 FFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
F L L L + +R + R F N L+ L LS N
Sbjct: 248 FKGLANLEYLLLKNSRIRNVTRDGFSGIN-NLKHLILSHN 286
Score = 89.0 bits (211), Expect = 5e-17
Identities = 86/325 (26%), Positives = 149/325 (45%), Gaps = 17/325 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLPDNA 104
I+C GL+ IP L ++ N + ES L+ LH+LV L + ++ + + A
Sbjct: 44 INCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKA 103
Query: 105 LYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRP 164
L L L L+ N+ L+P + +L+ L L +N+ + +L+
Sbjct: 104 FVQLRHLYFLFLNNNFIK---RLDPG-IFKGLLNLRNLYLQYNQVSFVPRGVFNDLV--- 156
Query: 165 SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCE 221
S++ L L + ++ G G++ +R+L L+ N +LRI +L L++ +
Sbjct: 157 SVQYLNLQRNRL-TVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNN 215
Query: 222 LTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC---NILQPNLKG 278
LT + N L SL L +S+N +E +L+Y+ + N+ + G
Sbjct: 216 LTKVPSNAFEVLKSLRRLSLSHN-PIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSG 274
Query: 279 FPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL-KMLKHLDLSW 337
+L+ IL+HN + L S+ F+ L YL L N I S+ DTF + LK L+LS+
Sbjct: 275 INNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSF 334
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRN 362
N + + L + SL L+ + N
Sbjct: 335 NNLTALHPRVLKPLSSLIHLQANSN 359
Score = 88.6 bits (210), Expect = 7e-17
Identities = 76/271 (28%), Positives = 130/271 (47%), Gaps = 7/271 (2%)
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN-NLFSQSLKYIDISYCNILQ 273
L+++ ++ +N +EL L SL L + N+ L + A L +++ ++ L
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 274 PNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
P + KG +LR L +N V ++ F + ++YL+L N + L TF G+ L+
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS---MSVTILDMSSCELNTIG 389
LDLS N I I E + +L L L N L++V S+ L +S + I
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 390 KDSLEGLQSIVELDLSQNLLSYIP-DSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTS 447
+ +GL ++ L L + + + D S N LK+L L++N + ++N+ TF +L L
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 448 LSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L + NR I +F + L+ L+LS N
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFN 335
Score = 86.2 bits (204), Expect = 4e-16
Identities = 77/292 (26%), Positives = 131/292 (44%), Gaps = 13/292 (4%)
Query: 211 SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--RLE--LASSANNLFSQSLKYIDI 266
SL +L++ N + + + L L L ++NN+ RL+ + NL + L+Y +
Sbjct: 85 SLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQV 144
Query: 267 SYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRG 326
S+ + + S++ L N + L S F L LDLSNNNI + F+
Sbjct: 145 SF--VPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQH 202
Query: 327 LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD---MSSC 383
L+ L L L N + +P ++ + SL +L LS N + + + L+ + +
Sbjct: 203 LENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNS 262
Query: 384 ELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYNRISSINNLTFFM 441
+ + +D G+ ++ L LS N L + S L YL L+ NRI SI+N TF
Sbjct: 263 RIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFEN 322
Query: 442 LNR-LTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDF 492
+ L L++ N T + R + + L + N W C+C +RD+
Sbjct: 323 MGASLKILNLSFNNLTALHPRVLKPLSSLIH-LQANSNPWECNCKLLGLRDW 373
Score = 83.8 bits (198), Expect = 2e-15
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 9/230 (3%)
Query: 187 GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE---LTSLNHNELMFLPSLTHLKMSN 243
GL+N+R L L +N + + + + L S+ N + LT L + + +L L +SN
Sbjct: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189
Query: 244 NYRLELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFA 301
N L ++ S +L + + Y+ + + N + SLR+ L+HN + ++ AF
Sbjct: 190 NNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK 249
Query: 302 NNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR 361
LEYL L N+ I ++ D F G+ LKHL LS N++ + D+ + +L LKL R
Sbjct: 250 GLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDR 309
Query: 362 NYLSRVGH--LRSM--SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
N + + + +M S+ IL++S L + L+ L S++ L + N
Sbjct: 310 NRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
>AY280614-1|AAP36706.1| 622|Homo sapiens synleurin protein.
Length = 622
Score = 91.5 bits (217), Expect = 1e-17
Identities = 81/280 (28%), Positives = 136/280 (48%), Gaps = 17/280 (6%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHL---KMSNNYRLELASSANNLFSQSLKYI---- 264
LR V C L L H E++ S+ L + N L L+S N F +S ++
Sbjct: 11 LRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKN-FPESTVFLYLTG 69
Query: 265 -DISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+ISY N + L G SL L+++ + Y+ AF L +L L+NN I L
Sbjct: 70 NNISYIN--ESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGI 127
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDM 380
F+GL L++L L +N+++ +P ++ S+ L L RN L+ +G + +++ ILD+
Sbjct: 128 FKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDL 187
Query: 381 SSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYNRISSINNLT 438
S+ + I + + L+++ L L N L+ +P + +L+ L+L++N I +I
Sbjct: 188 SNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA 247
Query: 439 FFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
F L L L + +R + R F N L+ L LS N
Sbjct: 248 FKGLANLEYLLLKNSRIRNVTRDGFSGIN-NLKHLILSHN 286
Score = 89.0 bits (211), Expect = 5e-17
Identities = 86/325 (26%), Positives = 149/325 (45%), Gaps = 17/325 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLPDNA 104
I+C GL+ IP L ++ N + ES L+ LH+LV L + ++ + + A
Sbjct: 44 INCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKA 103
Query: 105 LYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRP 164
L L L L+ N+ L+P + +L+ L L +N+ + +L+
Sbjct: 104 FVQLRHLYFLFLNNNFIK---RLDPG-IFKGLLNLRNLYLQYNQVSFVPRGVFNDLV--- 156
Query: 165 SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCE 221
S++ L L + ++ G G++ +R+L L+ N +LRI +L L++ +
Sbjct: 157 SVQYLNLQRNRL-TVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNN 215
Query: 222 LTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC---NILQPNLKG 278
LT + N L SL L +S+N +E +L+Y+ + N+ + G
Sbjct: 216 LTKVPSNAFEVLKSLRRLSLSHN-PIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSG 274
Query: 279 FPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL-KMLKHLDLSW 337
+L+ IL+HN + L S+ F+ L YL L N I S+ DTF + LK L+LS+
Sbjct: 275 INNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSF 334
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRN 362
N + + L + SL L+ + N
Sbjct: 335 NNLTALHPRVLKPLSSLIHLQANSN 359
Score = 88.6 bits (210), Expect = 7e-17
Identities = 76/271 (28%), Positives = 130/271 (47%), Gaps = 7/271 (2%)
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN-NLFSQSLKYIDISYCNILQ 273
L+++ ++ +N +EL L SL L + N+ L + A L +++ ++ L
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 274 PNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
P + KG +LR L +N V ++ F + ++YL+L N + L TF G+ L+
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS---MSVTILDMSSCELNTIG 389
LDLS N I I E + +L L L N L++V S+ L +S + I
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 390 KDSLEGLQSIVELDLSQNLLSYIP-DSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTS 447
+ +GL ++ L L + + + D S N LK+L L++N + ++N+ TF +L L
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 448 LSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L + NR I +F + L+ L+LS N
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFN 335
Score = 86.2 bits (204), Expect = 4e-16
Identities = 77/292 (26%), Positives = 131/292 (44%), Gaps = 13/292 (4%)
Query: 211 SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--RLE--LASSANNLFSQSLKYIDI 266
SL +L++ N + + + L L L ++NN+ RL+ + NL + L+Y +
Sbjct: 85 SLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQV 144
Query: 267 SYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRG 326
S+ + + S++ L N + L S F L LDLSNNNI + F+
Sbjct: 145 SF--VPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQH 202
Query: 327 LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD---MSSC 383
L+ L L L N + +P ++ + SL +L LS N + + + L+ + +
Sbjct: 203 LENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNS 262
Query: 384 ELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYNRISSINNLTFFM 441
+ + +D G+ ++ L LS N L + S L YL L+ NRI SI+N TF
Sbjct: 263 RIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFEN 322
Query: 442 LNR-LTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDF 492
+ L L++ N T + R + + L + N W C+C +RD+
Sbjct: 323 MGASLKILNLSFNNLTALHPRVLKPLSSLIH-LQANSNPWECNCKLLGLRDW 373
Score = 83.8 bits (198), Expect = 2e-15
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 9/230 (3%)
Query: 187 GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE---LTSLNHNELMFLPSLTHLKMSN 243
GL+N+R L L +N + + + + L S+ N + LT L + + +L L +SN
Sbjct: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189
Query: 244 NYRLELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFA 301
N L ++ S +L + + Y+ + + N + SLR+ L+HN + ++ AF
Sbjct: 190 NNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK 249
Query: 302 NNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR 361
LEYL L N+ I ++ D F G+ LKHL LS N++ + D+ + +L LKL R
Sbjct: 250 GLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDR 309
Query: 362 NYLSRVGH--LRSM--SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
N + + + +M S+ IL++S L + L+ L S++ L + N
Sbjct: 310 NRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
>AK123022-1|BAC85517.1| 622|Homo sapiens protein ( Homo sapiens
cDNA FLJ41026 fis, clone BRAMY2004771, weakly similar
to CHONDROADHERIN PRECURSOR. ).
Length = 622
Score = 91.5 bits (217), Expect = 1e-17
Identities = 81/280 (28%), Positives = 136/280 (48%), Gaps = 17/280 (6%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHL---KMSNNYRLELASSANNLFSQSLKYI---- 264
LR V C L L H E++ S+ L + N L L+S N F +S ++
Sbjct: 11 LRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKN-FPESTVFLYLTG 69
Query: 265 -DISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+ISY N + L G SL L+++ + Y+ AF L +L L+NN I L
Sbjct: 70 NNISYIN--ESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGI 127
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDM 380
F+GL L++L L +N+++ +P ++ S+ L L RN L+ +G + +++ ILD+
Sbjct: 128 FKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDL 187
Query: 381 SSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYNRISSINNLT 438
S+ + I + + L+++ L L N L+ +P + +L+ L+L++N I +I
Sbjct: 188 SNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA 247
Query: 439 FFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
F L L L + +R + R F N L+ L LS N
Sbjct: 248 FKGLANLEYLLLKNSRIRNVTRDGFSGIN-NLKHLILSHN 286
Score = 89.0 bits (211), Expect = 5e-17
Identities = 86/325 (26%), Positives = 149/325 (45%), Gaps = 17/325 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLPDNA 104
I+C GL+ IP L ++ N + ES L+ LH+LV L + ++ + + A
Sbjct: 44 INCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKA 103
Query: 105 LYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRP 164
L L L L+ N+ L+P + +L+ L L +N+ + +L+
Sbjct: 104 FVQLRHLYFLFLNNNFIK---RLDPG-IFKGLLNLRNLYLQYNQVSFVPRGVFNDLV--- 156
Query: 165 SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCE 221
S++ L L + ++ G G++ +R+L L+ N +LRI +L L++ +
Sbjct: 157 SVQYLNLQRNRL-TVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNN 215
Query: 222 LTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC---NILQPNLKG 278
LT + N L SL L +S+N +E +L+Y+ + N+ + G
Sbjct: 216 LTKVPSNAFEVLKSLRRLSLSHN-PIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSG 274
Query: 279 FPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL-KMLKHLDLSW 337
+L+ IL+HN + L S+ F+ L YL L N I S+ DTF + LK L+LS+
Sbjct: 275 INNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSF 334
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRN 362
N + + L + SL L+ + N
Sbjct: 335 NNLTALHPRVLKPLSSLIHLQANSN 359
Score = 88.6 bits (210), Expect = 7e-17
Identities = 76/271 (28%), Positives = 130/271 (47%), Gaps = 7/271 (2%)
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN-NLFSQSLKYIDISYCNILQ 273
L+++ ++ +N +EL L SL L + N+ L + A L +++ ++ L
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 274 PNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
P + KG +LR L +N V ++ F + ++YL+L N + L TF G+ L+
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS---MSVTILDMSSCELNTIG 389
LDLS N I I E + +L L L N L++V S+ L +S + I
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 390 KDSLEGLQSIVELDLSQNLLSYIP-DSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTS 447
+ +GL ++ L L + + + D S N LK+L L++N + ++N+ TF +L L
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 448 LSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L + NR I +F + L+ L+LS N
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFN 335
Score = 86.2 bits (204), Expect = 4e-16
Identities = 77/292 (26%), Positives = 131/292 (44%), Gaps = 13/292 (4%)
Query: 211 SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--RLE--LASSANNLFSQSLKYIDI 266
SL +L++ N + + + L L L ++NN+ RL+ + NL + L+Y +
Sbjct: 85 SLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQV 144
Query: 267 SYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRG 326
S+ + + S++ L N + L S F L LDLSNNNI + F+
Sbjct: 145 SF--VPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQH 202
Query: 327 LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD---MSSC 383
L+ L L L N + +P ++ + SL +L LS N + + + L+ + +
Sbjct: 203 LENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNS 262
Query: 384 ELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYNRISSINNLTFFM 441
+ + +D G+ ++ L LS N L + S L YL L+ NRI SI+N TF
Sbjct: 263 RIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFEN 322
Query: 442 LNR-LTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDF 492
+ L L++ N T + R + + L + N W C+C +RD+
Sbjct: 323 MGASLKILNLSFNNLTALHPRVLKPLSSLIH-LQANSNPWECNCKLLGLRDW 373
Score = 83.8 bits (198), Expect = 2e-15
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 9/230 (3%)
Query: 187 GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE---LTSLNHNELMFLPSLTHLKMSN 243
GL+N+R L L +N + + + + L S+ N + LT L + + +L L +SN
Sbjct: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189
Query: 244 NYRLELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFA 301
N L ++ S +L + + Y+ + + N + SLR+ L+HN + ++ AF
Sbjct: 190 NNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK 249
Query: 302 NNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR 361
LEYL L N+ I ++ D F G+ LKHL LS N++ + D+ + +L LKL R
Sbjct: 250 GLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDR 309
Query: 362 NYLSRVGH--LRSM--SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
N + + + +M S+ IL++S L + L+ L S++ L + N
Sbjct: 310 NRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
>BC057786-1|AAH57786.1| 512|Homo sapiens podocan-like 1 protein.
Length = 512
Score = 91.1 bits (216), Expect = 1e-17
Identities = 112/433 (25%), Positives = 199/433 (45%), Gaps = 33/433 (7%)
Query: 38 RCNLDKTD-IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSN 95
RC+ + D +DC L P+ + L++ NN+ + P LSRL L L++ +N
Sbjct: 49 RCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNN 108
Query: 96 QL--KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
+ +GLPD A +LT L+ L ++ N L++ P LP + L++ DL+ N+ +
Sbjct: 109 LISSEGLPDEAFESLTQLQHLCVAHNK----LSVAPQ--FLPRS-LRVADLAANQVMEIF 161
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSP--LSGLINIRVLKLNFNPLLRIQNLISSS 211
L E +P+L ++ L + ++++ G P G I L L+ N L + + S
Sbjct: 162 PLTFGE---KPALRSVYLHNNQLSNA-GLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPS 217
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCN 270
L L + N ++ + L L L + +N + A SL+Y+D+S+ N
Sbjct: 218 LERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSH-N 276
Query: 271 ILQPNLKGFP-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS--LRYDTFRGL 327
L G P +L L N +R +E+ L YL L +N + S L R L
Sbjct: 277 QLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPL 336
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRNYLSRVGH---LRSMSVTILDMSSC 383
+ L L L N + +P +P L L L N+++ +G + + +T L+++
Sbjct: 337 RGLHTLHLYGNGLDRVPP----ALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYN 392
Query: 384 ELNT--IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFM 441
L + + + L+++ LDL+ N L+ +P + + L+ L L N++ +
Sbjct: 393 RLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG-LRTLQLQRNQLRMLEPEPLAG 451
Query: 442 LNRLTSLSVVGNR 454
L++L LS+ NR
Sbjct: 452 LDQLRELSLAHNR 464
>BC113617-1|AAI13618.1| 757|Homo sapiens relaxin/insulin-like
family peptide receptor 1 protein.
Length = 757
Score = 90.2 bits (214), Expect = 2e-17
Identities = 62/193 (32%), Positives = 101/193 (52%), Gaps = 6/193 (3%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SL K L+HN + +L+ F + LE+L + +N+++ + TF GL L L L
Sbjct: 171 RGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLM 230
Query: 337 WNEIAVIPEDSLLE-MPSLTQLKLSRNYLSRVGHLRSMS---VTILDMSSCELNTIGKDS 392
N + +P+ L + MP L L L N++ + +L +S +T+L M ++N + +++
Sbjct: 231 NNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENT 290
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
LQ + ELDL N + +P I + L LNL+YN I I F L +L SLS+
Sbjct: 291 FAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSL 350
Query: 451 VGNRFTMIWRRSF 463
G + I +R F
Sbjct: 351 EGIEISNIQQRMF 363
Score = 67.7 bits (158), Expect = 1e-10
Identities = 62/213 (29%), Positives = 93/213 (43%), Gaps = 29/213 (13%)
Query: 273 QPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ NL+ PS+ + L N++R L + F N +L+ L L NN I S+ FRGL
Sbjct: 115 ETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 174
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI 388
L L LS N I + ++ L L + N+LSR I
Sbjct: 175 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSR---------------------I 213
Query: 389 GKDSLEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRL 445
+ GL S++ L L N+L+ +PD L +L+L N I ++ NLTF + L
Sbjct: 214 SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNL 273
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
T L + N+ + +F L+ LDL N
Sbjct: 274 TVLVMRKNKINHLNENTFAPLQK-LDELDLGSN 305
Score = 48.8 bits (111), Expect = 7e-05
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 7/208 (3%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL---FVSNCEL 222
L+ L L + +I SI + GL ++ L L+ N + ++ + L L + + L
Sbjct: 152 LQKLYLQNNKITSISIYA-FRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 210
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPNLKGF 279
+ ++ L SL L + NN L L ++D+ N+
Sbjct: 211 SRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISC 270
Query: 280 PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE 339
+L ++ N + +L N FA +L+ LDL +N I +L F+ LK L L+LS+N
Sbjct: 271 SNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNP 330
Query: 340 IAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
I I + + L L L +S +
Sbjct: 331 IQKIQANQFDYLVKLKSLSLEGIEISNI 358
Score = 48.8 bits (111), Expect = 7e-05
Identities = 49/194 (25%), Positives = 84/194 (43%), Gaps = 3/194 (1%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCN 270
L+ L++ N ++TS++ L SLT L +S+N L +L I+ ++ +
Sbjct: 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLS 211
Query: 271 -ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNT-ELEYLDLSNNNIASLRYDTFRGLK 328
I P G SL +L +N++ L + L +LDL N+I +LR TF
Sbjct: 212 RISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCS 271
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI 388
L L + N+I + E++ + L +L L N + + L + L + N I
Sbjct: 272 NLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPI 331
Query: 389 GKDSLEGLQSIVEL 402
K +V+L
Sbjct: 332 QKIQANQFDYLVKL 345
Score = 40.3 bits (90), Expect = 0.024
Identities = 69/308 (22%), Positives = 126/308 (40%), Gaps = 36/308 (11%)
Query: 30 IGDLCFLCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLV 88
+G + C C ++DC L +P+ + VT +++ N K P + H+L
Sbjct: 97 VGSVPVQCLCQ--GLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQ 153
Query: 89 NLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNK 148
L + +N++ + A L +L L LS N L P V L+ L + N
Sbjct: 154 KLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITF---LKPG-VFEDLHRLEWLIIEDNH 209
Query: 149 FQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLI 208
+ ++ SL L+L + + + + + + L L N + ++NL
Sbjct: 210 ---LSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLT 266
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLP--SLTHLKMSNNYRLELASSANNLFSQSLKYID 265
S +L V +NH NE F P L L + +N ++E + L + LK +
Sbjct: 267 FISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN-KIE---NLPPLIFKDLK--E 320
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+S N L++N ++ +++N F +L+ L L I++++ FR
Sbjct: 321 LSQLN----------------LSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFR 364
Query: 326 GLKMLKHL 333
L L H+
Sbjct: 365 PLMNLSHI 372
Score = 35.5 bits (78), Expect = 0.70
Identities = 41/157 (26%), Positives = 72/157 (45%), Gaps = 20/157 (12%)
Query: 64 VTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
+T L + N+ E+ + L L LD+ SN+++ LP +L L LNLS N
Sbjct: 273 LTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ 332
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH-- 180
+ N D L +K+ LS + + N+ Q+ + RP + L H
Sbjct: 333 K-IQANQFDYL-----VKLKSLSLEGIE-ISNI--QQRMFRPLMN---LSHIYFKKFQYC 380
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFV 217
G +P ++R K N + + ++NL++S ++ +FV
Sbjct: 381 GYAP-----HVRSCKPNTDGISSLENLLASIIQRVFV 412
>BC112142-1|AAI12143.1| 757|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 7 protein.
Length = 757
Score = 90.2 bits (214), Expect = 2e-17
Identities = 62/193 (32%), Positives = 101/193 (52%), Gaps = 6/193 (3%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SL K L+HN + +L+ F + LE+L + +N+++ + TF GL L L L
Sbjct: 171 RGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLM 230
Query: 337 WNEIAVIPEDSLLE-MPSLTQLKLSRNYLSRVGHLRSMS---VTILDMSSCELNTIGKDS 392
N + +P+ L + MP L L L N++ + +L +S +T+L M ++N + +++
Sbjct: 231 NNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENT 290
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
LQ + ELDL N + +P I + L LNL+YN I I F L +L SLS+
Sbjct: 291 FAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSL 350
Query: 451 VGNRFTMIWRRSF 463
G + I +R F
Sbjct: 351 EGIEISNIQQRMF 363
Score = 67.7 bits (158), Expect = 1e-10
Identities = 62/213 (29%), Positives = 93/213 (43%), Gaps = 29/213 (13%)
Query: 273 QPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ NL+ PS+ + L N++R L + F N +L+ L L NN I S+ FRGL
Sbjct: 115 ETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 174
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI 388
L L LS N I + ++ L L + N+LSR I
Sbjct: 175 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSR---------------------I 213
Query: 389 GKDSLEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRL 445
+ GL S++ L L N+L+ +PD L +L+L N I ++ NLTF + L
Sbjct: 214 SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNL 273
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
T L + N+ + +F L+ LDL N
Sbjct: 274 TVLVMRKNKINHLNENTFAPLQK-LDELDLGSN 305
Score = 48.8 bits (111), Expect = 7e-05
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 7/208 (3%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL---FVSNCEL 222
L+ L L + +I SI + GL ++ L L+ N + ++ + L L + + L
Sbjct: 152 LQKLYLQNNKITSISIYA-FRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 210
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPNLKGF 279
+ ++ L SL L + NN L L ++D+ N+
Sbjct: 211 SRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISC 270
Query: 280 PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE 339
+L ++ N + +L N FA +L+ LDL +N I +L F+ LK L L+LS+N
Sbjct: 271 SNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNP 330
Query: 340 IAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
I I + + L L L +S +
Sbjct: 331 IQKIQANQFDYLVKLKSLSLEGIEISNI 358
Score = 48.8 bits (111), Expect = 7e-05
Identities = 49/194 (25%), Positives = 84/194 (43%), Gaps = 3/194 (1%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCN 270
L+ L++ N ++TS++ L SLT L +S+N L +L I+ ++ +
Sbjct: 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLS 211
Query: 271 -ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNT-ELEYLDLSNNNIASLRYDTFRGLK 328
I P G SL +L +N++ L + L +LDL N+I +LR TF
Sbjct: 212 RISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCS 271
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI 388
L L + N+I + E++ + L +L L N + + L + L + N I
Sbjct: 272 NLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPI 331
Query: 389 GKDSLEGLQSIVEL 402
K +V+L
Sbjct: 332 QKIQANQFDYLVKL 345
Score = 40.3 bits (90), Expect = 0.024
Identities = 69/308 (22%), Positives = 126/308 (40%), Gaps = 36/308 (11%)
Query: 30 IGDLCFLCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLV 88
+G + C C ++DC L +P+ + VT +++ N K P + H+L
Sbjct: 97 VGSVPVQCLCQ--GLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQ 153
Query: 89 NLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNK 148
L + +N++ + A L +L L LS N L P V L+ L + N
Sbjct: 154 KLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITF---LKPG-VFEDLHRLEWLIIEDNH 209
Query: 149 FQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLI 208
+ ++ SL L+L + + + + + + L L N + ++NL
Sbjct: 210 ---LSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLT 266
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLP--SLTHLKMSNNYRLELASSANNLFSQSLKYID 265
S +L V +NH NE F P L L + +N ++E + L + LK +
Sbjct: 267 FISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN-KIE---NLPPLIFKDLK--E 320
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+S N L++N ++ +++N F +L+ L L I++++ FR
Sbjct: 321 LSQLN----------------LSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFR 364
Query: 326 GLKMLKHL 333
L L H+
Sbjct: 365 PLMNLSHI 372
Score = 35.5 bits (78), Expect = 0.70
Identities = 41/157 (26%), Positives = 72/157 (45%), Gaps = 20/157 (12%)
Query: 64 VTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
+T L + N+ E+ + L L LD+ SN+++ LP +L L LNLS N
Sbjct: 273 LTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ 332
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH-- 180
+ N D L +K+ LS + + N+ Q+ + RP + L H
Sbjct: 333 K-IQANQFDYL-----VKLKSLSLEGIE-ISNI--QQRMFRPLMN---LSHIYFKKFQYC 380
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFV 217
G +P ++R K N + + ++NL++S ++ +FV
Sbjct: 381 GYAP-----HVRSCKPNTDGISSLENLLASIIQRVFV 412
>AY899850-1|AAX85198.1| 724|Homo sapiens LGR7.10 protein.
Length = 724
Score = 90.2 bits (214), Expect = 2e-17
Identities = 62/193 (32%), Positives = 101/193 (52%), Gaps = 6/193 (3%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SL K L+HN + +L+ F + LE+L + +N+++ + TF GL L L L
Sbjct: 138 RGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLM 197
Query: 337 WNEIAVIPEDSLLE-MPSLTQLKLSRNYLSRVGHLRSMS---VTILDMSSCELNTIGKDS 392
N + +P+ L + MP L L L N++ + +L +S +T+L M ++N + +++
Sbjct: 198 NNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENT 257
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
LQ + ELDL N + +P I + L LNL+YN I I F L +L SLS+
Sbjct: 258 FAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSL 317
Query: 451 VGNRFTMIWRRSF 463
G + I +R F
Sbjct: 318 EGIEISNIQQRMF 330
Score = 67.7 bits (158), Expect = 1e-10
Identities = 62/213 (29%), Positives = 93/213 (43%), Gaps = 29/213 (13%)
Query: 273 QPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ NL+ PS+ + L N++R L + F N +L+ L L NN I S+ FRGL
Sbjct: 82 ETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 141
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI 388
L L LS N I + ++ L L + N+LSR I
Sbjct: 142 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSR---------------------I 180
Query: 389 GKDSLEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRL 445
+ GL S++ L L N+L+ +PD L +L+L N I ++ NLTF + L
Sbjct: 181 SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNL 240
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
T L + N+ + +F L+ LDL N
Sbjct: 241 TVLVMRKNKINHLNENTFAPLQK-LDELDLGSN 272
Score = 48.8 bits (111), Expect = 7e-05
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 7/208 (3%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL---FVSNCEL 222
L+ L L + +I SI + GL ++ L L+ N + ++ + L L + + L
Sbjct: 119 LQKLYLQNNKITSISIYA-FRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 177
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPNLKGF 279
+ ++ L SL L + NN L L ++D+ N+
Sbjct: 178 SRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISC 237
Query: 280 PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE 339
+L ++ N + +L N FA +L+ LDL +N I +L F+ LK L L+LS+N
Sbjct: 238 SNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNP 297
Query: 340 IAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
I I + + L L L +S +
Sbjct: 298 IQKIQANQFDYLVKLKSLSLEGIEISNI 325
Score = 48.8 bits (111), Expect = 7e-05
Identities = 49/194 (25%), Positives = 84/194 (43%), Gaps = 3/194 (1%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCN 270
L+ L++ N ++TS++ L SLT L +S+N L +L I+ ++ +
Sbjct: 119 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLS 178
Query: 271 -ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNT-ELEYLDLSNNNIASLRYDTFRGLK 328
I P G SL +L +N++ L + L +LDL N+I +LR TF
Sbjct: 179 RISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCS 238
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI 388
L L + N+I + E++ + L +L L N + + L + L + N I
Sbjct: 239 NLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPI 298
Query: 389 GKDSLEGLQSIVEL 402
K +V+L
Sbjct: 299 QKIQANQFDYLVKL 312
Score = 40.3 bits (90), Expect = 0.024
Identities = 69/308 (22%), Positives = 126/308 (40%), Gaps = 36/308 (11%)
Query: 30 IGDLCFLCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLV 88
+G + C C ++DC L +P+ + VT +++ N K P + H+L
Sbjct: 64 VGSVPVQCLCQ--GLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQ 120
Query: 89 NLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNK 148
L + +N++ + A L +L L LS N L P V L+ L + N
Sbjct: 121 KLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITF---LKPG-VFEDLHRLEWLIIEDNH 176
Query: 149 FQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLI 208
+ ++ SL L+L + + + + + + L L N + ++NL
Sbjct: 177 ---LSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLT 233
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLP--SLTHLKMSNNYRLELASSANNLFSQSLKYID 265
S +L V +NH NE F P L L + +N ++E + L + LK +
Sbjct: 234 FISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN-KIE---NLPPLIFKDLK--E 287
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+S N L++N ++ +++N F +L+ L L I++++ FR
Sbjct: 288 LSQLN----------------LSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFR 331
Query: 326 GLKMLKHL 333
L L H+
Sbjct: 332 PLMNLSHI 339
Score = 35.5 bits (78), Expect = 0.70
Identities = 41/157 (26%), Positives = 72/157 (45%), Gaps = 20/157 (12%)
Query: 64 VTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
+T L + N+ E+ + L L LD+ SN+++ LP +L L LNLS N
Sbjct: 240 LTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ 299
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH-- 180
+ N D L +K+ LS + + N+ Q+ + RP + L H
Sbjct: 300 K-IQANQFDYL-----VKLKSLSLEGIE-ISNI--QQRMFRPLMN---LSHIYFKKFQYC 347
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFV 217
G +P ++R K N + + ++NL++S ++ +FV
Sbjct: 348 GYAP-----HVRSCKPNTDGISSLENLLASIIQRVFV 379
>AF190500-1|AAG17167.1| 757|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 7 protein.
Length = 757
Score = 90.2 bits (214), Expect = 2e-17
Identities = 62/193 (32%), Positives = 101/193 (52%), Gaps = 6/193 (3%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SL K L+HN + +L+ F + LE+L + +N+++ + TF GL L L L
Sbjct: 171 RGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLM 230
Query: 337 WNEIAVIPEDSLLE-MPSLTQLKLSRNYLSRVGHLRSMS---VTILDMSSCELNTIGKDS 392
N + +P+ L + MP L L L N++ + +L +S +T+L M ++N + +++
Sbjct: 231 NNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENT 290
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
LQ + ELDL N + +P I + L LNL+YN I I F L +L SLS+
Sbjct: 291 FAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSL 350
Query: 451 VGNRFTMIWRRSF 463
G + I +R F
Sbjct: 351 EGIEISNIQQRMF 363
Score = 67.7 bits (158), Expect = 1e-10
Identities = 62/213 (29%), Positives = 93/213 (43%), Gaps = 29/213 (13%)
Query: 273 QPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ NL+ PS+ + L N++R L + F N +L+ L L NN I S+ FRGL
Sbjct: 115 ETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 174
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI 388
L L LS N I + ++ L L + N+LSR I
Sbjct: 175 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSR---------------------I 213
Query: 389 GKDSLEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRL 445
+ GL S++ L L N+L+ +PD L +L+L N I ++ NLTF + L
Sbjct: 214 SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNL 273
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
T L + N+ + +F L+ LDL N
Sbjct: 274 TVLVMRKNKINHLNENTFAPLQK-LDELDLGSN 305
Score = 48.8 bits (111), Expect = 7e-05
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 7/208 (3%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL---FVSNCEL 222
L+ L L + +I SI + GL ++ L L+ N + ++ + L L + + L
Sbjct: 152 LQKLYLQNNKITSISIYA-FRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 210
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPNLKGF 279
+ ++ L SL L + NN L L ++D+ N+
Sbjct: 211 SRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISC 270
Query: 280 PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE 339
+L ++ N + +L N FA +L+ LDL +N I +L F+ LK L L+LS+N
Sbjct: 271 SNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNP 330
Query: 340 IAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
I I + + L L L +S +
Sbjct: 331 IQKIQANQFDYLVKLKSLSLEGIEISNI 358
Score = 48.8 bits (111), Expect = 7e-05
Identities = 49/194 (25%), Positives = 84/194 (43%), Gaps = 3/194 (1%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCN 270
L+ L++ N ++TS++ L SLT L +S+N L +L I+ ++ +
Sbjct: 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLS 211
Query: 271 -ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNT-ELEYLDLSNNNIASLRYDTFRGLK 328
I P G SL +L +N++ L + L +LDL N+I +LR TF
Sbjct: 212 RISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCS 271
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI 388
L L + N+I + E++ + L +L L N + + L + L + N I
Sbjct: 272 NLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPI 331
Query: 389 GKDSLEGLQSIVEL 402
K +V+L
Sbjct: 332 QKIQANQFDYLVKL 345
Score = 40.3 bits (90), Expect = 0.024
Identities = 69/308 (22%), Positives = 126/308 (40%), Gaps = 36/308 (11%)
Query: 30 IGDLCFLCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLV 88
+G + C C ++DC L +P+ + VT +++ N K P + H+L
Sbjct: 97 VGSVPVQCLCQ--GLELDCDETNLRAVPS-VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQ 153
Query: 89 NLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNK 148
L + +N++ + A L +L L LS N L P V L+ L + N
Sbjct: 154 KLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITF---LKPG-VFEDLHRLEWLIIEDNH 209
Query: 149 FQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLI 208
+ ++ SL L+L + + + + + + L L N + ++NL
Sbjct: 210 ---LSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLT 266
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLP--SLTHLKMSNNYRLELASSANNLFSQSLKYID 265
S +L V +NH NE F P L L + +N ++E + L + LK +
Sbjct: 267 FISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN-KIE---NLPPLIFKDLK--E 320
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+S N L++N ++ +++N F +L+ L L I++++ FR
Sbjct: 321 LSQLN----------------LSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFR 364
Query: 326 GLKMLKHL 333
L L H+
Sbjct: 365 PLMNLSHI 372
Score = 35.5 bits (78), Expect = 0.70
Identities = 41/157 (26%), Positives = 72/157 (45%), Gaps = 20/157 (12%)
Query: 64 VTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
+T L + N+ E+ + L L LD+ SN+++ LP +L L LNLS N
Sbjct: 273 LTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ 332
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH-- 180
+ N D L +K+ LS + + N+ Q+ + RP + L H
Sbjct: 333 K-IQANQFDYL-----VKLKSLSLEGIE-ISNI--QQRMFRPLMN---LSHIYFKKFQYC 380
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFV 217
G +P ++R K N + + ++NL++S ++ +FV
Sbjct: 381 GYAP-----HVRSCKPNTDGISSLENLLASIIQRVFV 412
>AB208943-1|BAD92180.1| 627|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 7 variant
protein.
Length = 627
Score = 90.2 bits (214), Expect = 2e-17
Identities = 62/193 (32%), Positives = 101/193 (52%), Gaps = 6/193 (3%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SL K L+HN + +L+ F + LE+L + +N+++ + TF GL L L L
Sbjct: 41 RGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLM 100
Query: 337 WNEIAVIPEDSLLE-MPSLTQLKLSRNYLSRVGHLRSMS---VTILDMSSCELNTIGKDS 392
N + +P+ L + MP L L L N++ + +L +S +T+L M ++N + +++
Sbjct: 101 NNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENT 160
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
LQ + ELDL N + +P I + L LNL+YN I I F L +L SLS+
Sbjct: 161 FAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSL 220
Query: 451 VGNRFTMIWRRSF 463
G + I +R F
Sbjct: 221 EGIEISNIQQRMF 233
Score = 51.6 bits (118), Expect = 1e-05
Identities = 50/171 (29%), Positives = 72/171 (42%), Gaps = 25/171 (14%)
Query: 311 LSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL 370
L NN I S+ FRGL L L LS N I + ++ L L + N+LSR
Sbjct: 27 LQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSR---- 82
Query: 371 RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLN 427
I + GL S++ L L N+L+ +PD L +L+L
Sbjct: 83 -----------------ISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLE 125
Query: 428 YNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
N I ++ NLTF + LT L + N+ + +F L+ LDL N
Sbjct: 126 GNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQK-LDELDLGSN 175
Score = 46.8 bits (106), Expect = 3e-04
Identities = 40/159 (25%), Positives = 66/159 (41%), Gaps = 3/159 (1%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---Y 268
L L + + L+ ++ L SL L + NN L L ++D+
Sbjct: 70 LEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHI 129
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
N+ +L ++ N + +L N FA +L+ LDL +N I +L F+ LK
Sbjct: 130 HNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLK 189
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L+LS+N I I + + L L L +S +
Sbjct: 190 ELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNI 228
Score = 46.4 bits (105), Expect = 4e-04
Identities = 49/202 (24%), Positives = 87/202 (43%), Gaps = 3/202 (1%)
Query: 204 IQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLK 262
+++L+ S ++ N ++TS++ L SLT L +S+N L +L
Sbjct: 14 LKSLLYHSRNLGYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWL 73
Query: 263 YIDISYCN-ILQPNLKGFPSLRKAILNHNMVRYLESNAFANN-TELEYLDLSNNNIASLR 320
I+ ++ + I P G SL +L +N++ L + L +LDL N+I +LR
Sbjct: 74 IIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLR 133
Query: 321 YDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDM 380
TF L L + N+I + E++ + L +L L N + + L + L
Sbjct: 134 NLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQ 193
Query: 381 SSCELNTIGKDSLEGLQSIVEL 402
+ N I K +V+L
Sbjct: 194 LNLSYNPIQKIQANQFDYLVKL 215
Score = 41.1 bits (92), Expect = 0.014
Identities = 58/237 (24%), Positives = 93/237 (39%), Gaps = 19/237 (8%)
Query: 64 VTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
+TKL +S+N T P LH L L I N L + Y L +L +L L N
Sbjct: 46 LTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL- 104
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGR 182
+ L P +P H LDL N NL N + +L L++ +IN ++
Sbjct: 105 TRLPDKPLCQHMPRLHW--LDLEGNHIH---NLRNLTFISCSNLTVLVMRKNKINHLN-E 158
Query: 183 SPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
+ + L + L L N + + LI L+ L N + + L LK
Sbjct: 159 NTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSL 218
Query: 243 NNYRLELASSANNLFS--QSLKYI---DISYCNI------LQPNLKGFPSLRKAILN 288
+ +E+++ +F +L +I YC +PN G SL +++
Sbjct: 219 SLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLVS 275
Score = 34.3 bits (75), Expect = 1.6
Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 20/157 (12%)
Query: 64 VTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
+T L + N+ E+ + L L LD+ SN+++ LP +L L LNLS N
Sbjct: 143 LTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQ 202
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH-- 180
+ N D L +K+ LS + + N+ Q+ + RP + L H
Sbjct: 203 K-IQANQFDYL-----VKLKSLSLEGIE-ISNI--QQRMFRPLMN---LSHIYFKKFQYC 250
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFV 217
G +P ++R K N + + ++NL+ S ++ +FV
Sbjct: 251 GYAP-----HVRSCKPNTDGISSLENLLVSIIQRVFV 282
>AY358114-1|AAQ88481.1| 606|Homo sapiens Tango hlg protein.
Length = 606
Score = 89.4 bits (212), Expect = 4e-17
Identities = 86/335 (25%), Positives = 154/335 (45%), Gaps = 14/335 (4%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ + C RR L IP G+ ++ L++S N PE L +D+S N
Sbjct: 32 CECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDN 91
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + A NL L L L N L L P V ++L LD+S NK + +
Sbjct: 92 IIANVEPGAFNNLFNLRSLRLKGNR----LKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
Q+L +L++L + ++ I R+ SGL+++ L L L + S LRSL
Sbjct: 148 MFQDL---HNLKSLEVGDNDLVYISHRA-FSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203
Query: 216 FVSNCELTSLNHNELMFLPSLTHLK-MSNNY-RLELASSANNLFSQSLKYIDISYCNI-L 272
+ + ++N+ + L HLK + +Y L AN+L+ +L + ++ N+
Sbjct: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263
Query: 273 QPNL--KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L K L L++N + +E+ F++ L+ L + + ++ +F+GL+ L
Sbjct: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFL 323
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L++S N + + E+ +L L ++ N L+
Sbjct: 324 RVLNVSQNLLETLEENVFSSPRALEVLSINNNPLA 358
Score = 72.9 bits (171), Expect = 4e-12
Identities = 76/291 (26%), Positives = 133/291 (45%), Gaps = 18/291 (6%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFS- 258
L+ I I + L +S L S+N E + P L + +S+N + A NNLF+
Sbjct: 48 LIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNL 107
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+SL+ + G +L K ++ N + L F + L+ L++ +N++
Sbjct: 108 RSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVY 167
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS--------RVGHL 370
+ + F GL L+ L L + +P ++L + SL L L ++ R+ HL
Sbjct: 168 ISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHL 227
Query: 371 RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNY 428
+ + + + L+ + +SL GL ++ L ++ LS +P + L +LNL+Y
Sbjct: 228 KHLEIDYWPL----LDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSY 282
Query: 429 NRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N IS+I F L RL L +VG + I S F +L L++S N+
Sbjct: 283 NPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHS-FQGLRFLRVLNVSQNL 332
Score = 62.9 bits (146), Expect = 4e-09
Identities = 81/329 (24%), Positives = 153/329 (46%), Gaps = 23/329 (6%)
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
KILDLS N+ +++ +E + P LE + L I ++ + + L N+R L+L N
Sbjct: 60 KILDLSKNRLKSVNP---EEFISYPLLEEIDLSDNIIANVEPGA-FNNLFNLRSLRLKGN 115
Query: 200 PLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNL 256
L + + S+L L +S ++ L L +L L++ +N +L ++
Sbjct: 116 RLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDN---DLVYISHRA 172
Query: 257 FSQ--SLKYIDISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDL 311
FS SL+ + + CN+ + LR I L H + + AF L++L++
Sbjct: 173 FSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEI 232
Query: 312 SNNNIASLR-YDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--G 368
+ + ++ GL L L ++ ++ +P + + LT L LS N +S + G
Sbjct: 233 DYWPLLDMMPANSLYGLN-LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAG 291
Query: 369 HLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLN 425
+ + L + +L TI S +GL+ + L++SQNLL + +++ S L+ L+
Sbjct: 292 MFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLS 351
Query: 426 LNYNRISSINNLTFFMLNRLTSLSVVGNR 454
+N N ++ L ++L R +L G +
Sbjct: 352 INNNPLACDCRL-LWILQRQPTLQFGGQQ 379
>AL353746-1|CAC22713.1| 606|Homo sapiens leucine rich repeat
neuronal 6C protein.
Length = 606
Score = 89.4 bits (212), Expect = 4e-17
Identities = 86/335 (25%), Positives = 154/335 (45%), Gaps = 14/335 (4%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ + C RR L IP G+ ++ L++S N PE L +D+S N
Sbjct: 32 CECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDN 91
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + A NL L L L N L L P V ++L LD+S NK + +
Sbjct: 92 IIANVEPGAFNNLFNLRSLRLKGNR----LKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
Q+L +L++L + ++ I R+ SGL+++ L L L + S LRSL
Sbjct: 148 MFQDL---HNLKSLEVGDNDLVYISHRA-FSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203
Query: 216 FVSNCELTSLNHNELMFLPSLTHLK-MSNNY-RLELASSANNLFSQSLKYIDISYCNI-L 272
+ + ++N+ + L HLK + +Y L AN+L+ +L + ++ N+
Sbjct: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263
Query: 273 QPNL--KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L K L L++N + +E+ F++ L+ L + + ++ +F+GL+ L
Sbjct: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFL 323
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L++S N + + E+ +L L ++ N L+
Sbjct: 324 RVLNVSQNLLETLEENVFSSPRALEVLSINNNPLA 358
Score = 72.9 bits (171), Expect = 4e-12
Identities = 76/291 (26%), Positives = 133/291 (45%), Gaps = 18/291 (6%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFS- 258
L+ I I + L +S L S+N E + P L + +S+N + A NNLF+
Sbjct: 48 LIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNL 107
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+SL+ + G +L K ++ N + L F + L+ L++ +N++
Sbjct: 108 RSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVY 167
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS--------RVGHL 370
+ + F GL L+ L L + +P ++L + SL L L ++ R+ HL
Sbjct: 168 ISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHL 227
Query: 371 RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNY 428
+ + + + L+ + +SL GL ++ L ++ LS +P + L +LNL+Y
Sbjct: 228 KHLEIDYWPL----LDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSY 282
Query: 429 NRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N IS+I F L RL L +VG + I S F +L L++S N+
Sbjct: 283 NPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHS-FQGLRFLRVLNVSQNL 332
Score = 62.9 bits (146), Expect = 4e-09
Identities = 81/329 (24%), Positives = 153/329 (46%), Gaps = 23/329 (6%)
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
KILDLS N+ +++ +E + P LE + L I ++ + + L N+R L+L N
Sbjct: 60 KILDLSKNRLKSVNP---EEFISYPLLEEIDLSDNIIANVEPGA-FNNLFNLRSLRLKGN 115
Query: 200 PLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNL 256
L + + S+L L +S ++ L L +L L++ +N +L ++
Sbjct: 116 RLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDN---DLVYISHRA 172
Query: 257 FSQ--SLKYIDISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDL 311
FS SL+ + + CN+ + LR I L H + + AF L++L++
Sbjct: 173 FSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEI 232
Query: 312 SNNNIASLR-YDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--G 368
+ + ++ GL L L ++ ++ +P + + LT L LS N +S + G
Sbjct: 233 DYWPLLDMMPANSLYGLN-LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAG 291
Query: 369 HLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLN 425
+ + L + +L TI S +GL+ + L++SQNLL + +++ S L+ L+
Sbjct: 292 MFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLS 351
Query: 426 LNYNRISSINNLTFFMLNRLTSLSVVGNR 454
+N N ++ L ++L R +L G +
Sbjct: 352 INNNPLACDCRL-LWILQRQPTLQFGGQQ 379
>AK056372-1|BAB71167.1| 606|Homo sapiens protein ( Homo sapiens
cDNA FLJ31810 fis, clone NT2RI2009289, weakly similar to
CARBOXYPEPTIDASE N 83 KD CHAIN. ).
Length = 606
Score = 89.4 bits (212), Expect = 4e-17
Identities = 86/335 (25%), Positives = 154/335 (45%), Gaps = 14/335 (4%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ + C RR L IP G+ ++ L++S N PE L +D+S N
Sbjct: 32 CECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDN 91
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + A NL L L L N L L P V ++L LD+S NK + +
Sbjct: 92 IIANVEPGAFNNLFNLRSLRLKGNR----LKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
Q+L +L++L + ++ I R+ SGL+++ L L L + S LRSL
Sbjct: 148 MFQDL---HNLKSLEVGDNDLVYISHRA-FSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203
Query: 216 FVSNCELTSLNHNELMFLPSLTHLK-MSNNY-RLELASSANNLFSQSLKYIDISYCNI-L 272
+ + ++N+ + L HLK + +Y L AN+L+ +L + ++ N+
Sbjct: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263
Query: 273 QPNL--KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L K L L++N + +E+ F++ L+ L + + ++ +F+GL+ L
Sbjct: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFL 323
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L++S N + + E+ +L L ++ N L+
Sbjct: 324 RVLNVSQNLLETLEENVFSSPRALEVLSINNNPLA 358
Score = 72.9 bits (171), Expect = 4e-12
Identities = 76/291 (26%), Positives = 133/291 (45%), Gaps = 18/291 (6%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFS- 258
L+ I I + L +S L S+N E + P L + +S+N + A NNLF+
Sbjct: 48 LIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNL 107
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+SL+ + G +L K ++ N + L F + L+ L++ +N++
Sbjct: 108 RSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVY 167
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS--------RVGHL 370
+ + F GL L+ L L + +P ++L + SL L L ++ R+ HL
Sbjct: 168 ISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHL 227
Query: 371 RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNY 428
+ + + + L+ + +SL GL ++ L ++ LS +P + L +LNL+Y
Sbjct: 228 KHLEIDYWPL----LDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSY 282
Query: 429 NRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N IS+I F L RL L +VG + I S F +L L++S N+
Sbjct: 283 NPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHS-FQGLRFLRVLNVSQNL 332
Score = 62.9 bits (146), Expect = 4e-09
Identities = 81/329 (24%), Positives = 153/329 (46%), Gaps = 23/329 (6%)
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
KILDLS N+ +++ +E + P LE + L I ++ + + L N+R L+L N
Sbjct: 60 KILDLSKNRLKSVNP---EEFISYPLLEEIDLSDNIIANVEPGA-FNNLFNLRSLRLKGN 115
Query: 200 PLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNL 256
L + + S+L L +S ++ L L +L L++ +N +L ++
Sbjct: 116 RLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDN---DLVYISHRA 172
Query: 257 FSQ--SLKYIDISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDL 311
FS SL+ + + CN+ + LR I L H + + AF L++L++
Sbjct: 173 FSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEI 232
Query: 312 SNNNIASLR-YDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--G 368
+ + ++ GL L L ++ ++ +P + + LT L LS N +S + G
Sbjct: 233 DYWPLLDMMPANSLYGLN-LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAG 291
Query: 369 HLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLN 425
+ + L + +L TI S +GL+ + L++SQNLL + +++ S L+ L+
Sbjct: 292 MFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLS 351
Query: 426 LNYNRISSINNLTFFMLNRLTSLSVVGNR 454
+N N ++ L ++L R +L G +
Sbjct: 352 INNNPLACDCRL-LWILQRQPTLQFGGQQ 379
>BC099650-1|AAH99650.1| 907|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 5 protein.
Length = 907
Score = 89.0 bits (211), Expect = 5e-17
Identities = 110/423 (26%), Positives = 189/423 (44%), Gaps = 37/423 (8%)
Query: 61 GLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
G + +++ S+ ++ P +LS + LD+S N + L N L +L LE L L+ N
Sbjct: 44 GRMLLRVDCSDLGLSELPSNLSVFTSY--LDLSMNNISQLLPNPLPSLRFLEELRLAGNA 101
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
L P LK+L L N+ + + A Q L SL++L LD I+ +
Sbjct: 102 ----LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLR---SLQSLRLDANHISYVP 154
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLK 240
S SGL ++R L L+ N L I SL +L L ++H +L+ L
Sbjct: 155 P-SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
Query: 241 MSNNYRLELASSANNLFS--QSLKYIDISYCNILQ-PN-LKGFPSLRKAILNHNMVRYLE 296
+ + + + S F SL+ +D++Y N+ + P ++ +L++ + N +R +
Sbjct: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273
Query: 297 SNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQ 356
AF N L + +N I + F+ L L+ L L+ + E P LT
Sbjct: 274 EKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG-------ASQITEFPDLTG 326
Query: 357 LKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI 416
+L S+++T +++++ + L ++ LDLS NLL +P
Sbjct: 327 ----------TANLESLTLT-----GAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFS 371
Query: 417 SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
L+ ++L +N I I TF L L SL++ N+ +I + F + P L +LDLS
Sbjct: 372 VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII-HPNAFSTLPSLIKLDLS 430
Query: 477 DNM 479
N+
Sbjct: 431 SNL 433
Score = 87.0 bits (206), Expect = 2e-16
Identities = 96/346 (27%), Positives = 160/346 (46%), Gaps = 45/346 (13%)
Query: 53 LTDIPNGL--GLQVTK-LNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT IP G GL K L + NN+ P E+L L +L +L + +N + +P + L
Sbjct: 102 LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL 161
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
+L L L D+ L P + L+ + L+ NK + + A +L +
Sbjct: 162 HSLRHLWLD----DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFG------NLSS 211
Query: 169 LILDHCEINSIH--GRSPLSGLINIRVLKLNFNPLLRIQNLI------------SSSLRS 214
L++ H N IH G+ GL ++ L LN+N L I S+++RS
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRS 271
Query: 215 L----FVSNCELTSLNH--NELMF--------LPSLTHLKMSNNYRL-ELASSANNLFSQ 259
+ FV N L +++ N + F LP L L ++ ++ E +
Sbjct: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLE 331
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ Q P+L+ L++N++ L S F+ +L+ +DL +N I +
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEI 389
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ DTF+ L L+ L+L+WN+IA+I ++ +PSL +L LS N LS
Sbjct: 390 KVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435
Score = 80.2 bits (189), Expect = 2e-14
Identities = 108/407 (26%), Positives = 176/407 (43%), Gaps = 36/407 (8%)
Query: 37 CRCNLDKT---DIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDI 92
C C D +DCS GL+++P+ L + + L++S N ++ P L L L L +
Sbjct: 38 CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRL 97
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYF-----DSWLNLNPNDVL-LPATHLKILDLS- 145
+ N L +P A L +L+VL L N ++ NL L L A H+ + S
Sbjct: 98 AGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSC 157
Query: 146 FNKFQTMGNL-----ANQELLIRP--SLETLILDHCEINSIHGRSPLS--GLINIRVLKL 196
F+ ++ +L A E+ ++ SL L +N IH + L ++ VL L
Sbjct: 158 FSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHL 217
Query: 197 NFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS----LTHLKMSNNYRLELASS 252
+ N + + L SL E LN+N L P+ L++LK + + S
Sbjct: 218 HNNRIHSLGKKCFDGLHSL-----ETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSI 272
Query: 253 ANNLFSQSLKYIDIS-YCNILQ----PNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
F + I I Y N +Q + P LR LN + E LE
Sbjct: 273 PEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLN-GASQITEFPDLTGTANLE 331
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L+ I+SL L L+ LDLS+N + +P S+ + L+ + Y +V
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKV 391
Query: 368 GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
+ + S+ L+++ ++ I ++ L S+++LDLS NLLS P
Sbjct: 392 DTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP 438
Score = 66.5 bits (155), Expect = 3e-10
Identities = 80/296 (27%), Positives = 133/296 (44%), Gaps = 22/296 (7%)
Query: 67 LNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+ ++ N+ P+ + L +LV L + +N++ L L +LE L+L+ N D +
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF- 249
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
P + ++LK L N +++ A + PSL T+ I + GRS
Sbjct: 250 ---PT-AIRTLSNLKELGFHSNNIRSIPEKA---FVGNPSLITIHFYDNPIQFV-GRSAF 301
Query: 186 SGLINIRVLKLN-FNPLLRIQNLI-SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L +R L LN + + +L +++L SL ++ +++SL LP+L L +S
Sbjct: 302 QHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSY 361
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFP---SLRKAILNHNMVRYLESNAF 300
N +L S + Q L+ ID+ + I + + F SLR L N + + NAF
Sbjct: 362 NLLEDLPSFS---VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 418
Query: 301 ANNTELEYLDLSNNNIASLRYDTFRGLKMLK----HLDLSWNEIAVIPEDSLLEMP 352
+ L LDLS+N ++S GL LK H S PE ++EMP
Sbjct: 419 STLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMP 474
Score = 46.4 bits (105), Expect = 4e-04
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 14/175 (8%)
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
++Q+ PD L LE L L+ S P V +L++LDLS+N + +
Sbjct: 315 ASQITEFPD--LTGTANLESLTLTGAQISSL----PQTVCNQLPNLQVLDLSYNLLEDLP 368
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + + L+ + L H EI I + L+++R L L +N + I S+L
Sbjct: 369 SFS-----VCQKLQKIDLRHNEIYEIKVDT-FQQLLSLRSLNLAWNKIAIIHPNAFSTLP 422
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
SL + L+ + L LTHLK++ N+ L+ S+ N LK I++ Y
Sbjct: 423 SLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENF--PELKVIEMPY 475
Score = 35.5 bits (78), Expect = 0.70
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 1/53 (1%)
Query: 62 LQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEV 113
L + LN++ N+ P + S L +L+ LD+SSN L P L+ LT L++
Sbjct: 398 LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKL 450
>BC096324-1|AAH96324.1| 907|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 5 protein.
Length = 907
Score = 89.0 bits (211), Expect = 5e-17
Identities = 110/423 (26%), Positives = 189/423 (44%), Gaps = 37/423 (8%)
Query: 61 GLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
G + +++ S+ ++ P +LS + LD+S N + L N L +L LE L L+ N
Sbjct: 44 GRMLLRVDCSDLGLSELPSNLSVFTSY--LDLSMNNISQLLPNPLPSLRFLEELRLAGNA 101
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
L P LK+L L N+ + + A Q L SL++L LD I+ +
Sbjct: 102 ----LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLR---SLQSLRLDANHISYVP 154
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLK 240
S SGL ++R L L+ N L I SL +L L ++H +L+ L
Sbjct: 155 P-SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
Query: 241 MSNNYRLELASSANNLFS--QSLKYIDISYCNILQ-PN-LKGFPSLRKAILNHNMVRYLE 296
+ + + + S F SL+ +D++Y N+ + P ++ +L++ + N +R +
Sbjct: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273
Query: 297 SNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQ 356
AF N L + +N I + F+ L L+ L L+ + E P LT
Sbjct: 274 EKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG-------ASQITEFPDLTG 326
Query: 357 LKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI 416
+L S+++T +++++ + L ++ LDLS NLL +P
Sbjct: 327 ----------TANLESLTLT-----GAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFS 371
Query: 417 SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
L+ ++L +N I I TF L L SL++ N+ +I + F + P L +LDLS
Sbjct: 372 VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII-HPNAFSTLPSLIKLDLS 430
Query: 477 DNM 479
N+
Sbjct: 431 SNL 433
Score = 87.0 bits (206), Expect = 2e-16
Identities = 96/346 (27%), Positives = 160/346 (46%), Gaps = 45/346 (13%)
Query: 53 LTDIPNGL--GLQVTK-LNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT IP G GL K L + NN+ P E+L L +L +L + +N + +P + L
Sbjct: 102 LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL 161
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
+L L L D+ L P + L+ + L+ NK + + A +L +
Sbjct: 162 HSLRHLWLD----DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFG------NLSS 211
Query: 169 LILDHCEINSIH--GRSPLSGLINIRVLKLNFNPLLRIQNLI------------SSSLRS 214
L++ H N IH G+ GL ++ L LN+N L I S+++RS
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRS 271
Query: 215 L----FVSNCELTSLNH--NELMF--------LPSLTHLKMSNNYRL-ELASSANNLFSQ 259
+ FV N L +++ N + F LP L L ++ ++ E +
Sbjct: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLE 331
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ Q P+L+ L++N++ L S F+ +L+ +DL +N I +
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEI 389
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ DTF+ L L+ L+L+WN+IA+I ++ +PSL +L LS N LS
Sbjct: 390 KVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435
Score = 80.2 bits (189), Expect = 2e-14
Identities = 108/407 (26%), Positives = 176/407 (43%), Gaps = 36/407 (8%)
Query: 37 CRCNLDKT---DIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDI 92
C C D +DCS GL+++P+ L + + L++S N ++ P L L L L +
Sbjct: 38 CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRL 97
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYF-----DSWLNLNPNDVL-LPATHLKILDLS- 145
+ N L +P A L +L+VL L N ++ NL L L A H+ + S
Sbjct: 98 AGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSC 157
Query: 146 FNKFQTMGNL-----ANQELLIRP--SLETLILDHCEINSIHGRSPLS--GLINIRVLKL 196
F+ ++ +L A E+ ++ SL L +N IH + L ++ VL L
Sbjct: 158 FSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHL 217
Query: 197 NFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS----LTHLKMSNNYRLELASS 252
+ N + + L SL E LN+N L P+ L++LK + + S
Sbjct: 218 HNNRIHSLGKKCFDGLHSL-----ETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSI 272
Query: 253 ANNLFSQSLKYIDIS-YCNILQ----PNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
F + I I Y N +Q + P LR LN + E LE
Sbjct: 273 PEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLN-GASQITEFPDLTGTANLE 331
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L+ I+SL L L+ LDLS+N + +P S+ + L+ + Y +V
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKV 391
Query: 368 GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
+ + S+ L+++ ++ I ++ L S+++LDLS NLLS P
Sbjct: 392 DTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP 438
Score = 66.5 bits (155), Expect = 3e-10
Identities = 80/296 (27%), Positives = 133/296 (44%), Gaps = 22/296 (7%)
Query: 67 LNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+ ++ N+ P+ + L +LV L + +N++ L L +LE L+L+ N D +
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF- 249
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
P + ++LK L N +++ A + PSL T+ I + GRS
Sbjct: 250 ---PT-AIRTLSNLKELGFHSNNIRSIPEKA---FVGNPSLITIHFYDNPIQFV-GRSAF 301
Query: 186 SGLINIRVLKLN-FNPLLRIQNLI-SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L +R L LN + + +L +++L SL ++ +++SL LP+L L +S
Sbjct: 302 QHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSY 361
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFP---SLRKAILNHNMVRYLESNAF 300
N +L S + Q L+ ID+ + I + + F SLR L N + + NAF
Sbjct: 362 NLLEDLPSFS---VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 418
Query: 301 ANNTELEYLDLSNNNIASLRYDTFRGLKMLK----HLDLSWNEIAVIPEDSLLEMP 352
+ L LDLS+N ++S GL LK H S PE ++EMP
Sbjct: 419 STLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMP 474
Score = 46.4 bits (105), Expect = 4e-04
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 14/175 (8%)
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
++Q+ PD L LE L L+ S P V +L++LDLS+N + +
Sbjct: 315 ASQITEFPD--LTGTANLESLTLTGAQISSL----PQTVCNQLPNLQVLDLSYNLLEDLP 368
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + + L+ + L H EI I + L+++R L L +N + I S+L
Sbjct: 369 SFS-----VCQKLQKIDLRHNEIYEIKVDT-FQQLLSLRSLNLAWNKIAIIHPNAFSTLP 422
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
SL + L+ + L LTHLK++ N+ L+ S+ N LK I++ Y
Sbjct: 423 SLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENF--PELKVIEMPY 475
Score = 35.5 bits (78), Expect = 0.70
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 1/53 (1%)
Query: 62 LQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEV 113
L + LN++ N+ P + S L +L+ LD+SSN L P L+ LT L++
Sbjct: 398 LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKL 450
>AF062006-1|AAC28019.1| 907|Homo sapiens orphan G protein-coupled
receptor HG38 protein.
Length = 907
Score = 89.0 bits (211), Expect = 5e-17
Identities = 110/423 (26%), Positives = 189/423 (44%), Gaps = 37/423 (8%)
Query: 61 GLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
G + +++ S+ ++ P +LS + LD+S N + L N L +L LE L L+ N
Sbjct: 44 GRMLLRVDCSDLGLSELPSNLSVFTSY--LDLSMNNISQLLPNPLPSLRFLEELRLAGNA 101
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
L P LK+L L N+ + + A Q L SL++L LD I+ +
Sbjct: 102 ----LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLR---SLQSLRLDANHISYVP 154
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLK 240
S SGL ++R L L+ N L I SL +L L ++H +L+ L
Sbjct: 155 P-SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
Query: 241 MSNNYRLELASSANNLFS--QSLKYIDISYCNILQ-PN-LKGFPSLRKAILNHNMVRYLE 296
+ + + + S F SL+ +D++Y N+ + P ++ +L++ + N +R +
Sbjct: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273
Query: 297 SNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQ 356
AF N L + +N I + F+ L L+ L L+ + E P LT
Sbjct: 274 EKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG-------ASQITEFPDLTG 326
Query: 357 LKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI 416
+L S+++T +++++ + L ++ LDLS NLL +P
Sbjct: 327 ----------TANLESLTLT-----GAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFS 371
Query: 417 SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
L+ ++L +N I I TF L L SL++ N+ +I + F + P L +LDLS
Sbjct: 372 VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII-HPNAFSTLPSLIKLDLS 430
Query: 477 DNM 479
N+
Sbjct: 431 SNL 433
Score = 87.0 bits (206), Expect = 2e-16
Identities = 96/346 (27%), Positives = 160/346 (46%), Gaps = 45/346 (13%)
Query: 53 LTDIPNGL--GLQVTK-LNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT IP G GL K L + NN+ P E+L L +L +L + +N + +P + L
Sbjct: 102 LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL 161
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
+L L L D+ L P + L+ + L+ NK + + A +L +
Sbjct: 162 HSLRHLWLD----DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFG------NLSS 211
Query: 169 LILDHCEINSIH--GRSPLSGLINIRVLKLNFNPLLRIQNLI------------SSSLRS 214
L++ H N IH G+ GL ++ L LN+N L I S+++RS
Sbjct: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRS 271
Query: 215 L----FVSNCELTSLNH--NELMF--------LPSLTHLKMSNNYRL-ELASSANNLFSQ 259
+ FV N L +++ N + F LP L L ++ ++ E +
Sbjct: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLE 331
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ Q P+L+ L++N++ L S F+ +L+ +DL +N I +
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEI 389
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ DTF+ L L+ L+L+WN+IA+I ++ +PSL +L LS N LS
Sbjct: 390 KVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435
Score = 80.2 bits (189), Expect = 2e-14
Identities = 108/407 (26%), Positives = 176/407 (43%), Gaps = 36/407 (8%)
Query: 37 CRCNLDKT---DIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDI 92
C C D +DCS GL+++P+ L + + L++S N ++ P L L L L +
Sbjct: 38 CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRL 97
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYF-----DSWLNLNPNDVL-LPATHLKILDLS- 145
+ N L +P A L +L+VL L N ++ NL L L A H+ + S
Sbjct: 98 AGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSC 157
Query: 146 FNKFQTMGNL-----ANQELLIRP--SLETLILDHCEINSIHGRSPLS--GLINIRVLKL 196
F+ ++ +L A E+ ++ SL L +N IH + L ++ VL L
Sbjct: 158 FSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHL 217
Query: 197 NFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS----LTHLKMSNNYRLELASS 252
+ N + + L SL E LN+N L P+ L++LK + + S
Sbjct: 218 HNNRIHSLGKKCFDGLHSL-----ETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSI 272
Query: 253 ANNLFSQSLKYIDIS-YCNILQ----PNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
F + I I Y N +Q + P LR LN + E LE
Sbjct: 273 PEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLN-GASQITEFPDLTGTANLE 331
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L+ I+SL L L+ LDLS+N + +P S+ + L+ + Y +V
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKV 391
Query: 368 GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
+ + S+ L+++ ++ I ++ L S+++LDLS NLLS P
Sbjct: 392 DTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP 438
Score = 66.5 bits (155), Expect = 3e-10
Identities = 80/296 (27%), Positives = 133/296 (44%), Gaps = 22/296 (7%)
Query: 67 LNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+ ++ N+ P+ + L +LV L + +N++ L L +LE L+L+ N D +
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF- 249
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
P + ++LK L N +++ A + PSL T+ I + GRS
Sbjct: 250 ---PT-AIRTLSNLKELGFHSNNIRSIPEKA---FVGNPSLITIHFYDNPIQFV-GRSAF 301
Query: 186 SGLINIRVLKLN-FNPLLRIQNLI-SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L +R L LN + + +L +++L SL ++ +++SL LP+L L +S
Sbjct: 302 QHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSY 361
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFP---SLRKAILNHNMVRYLESNAF 300
N +L S + Q L+ ID+ + I + + F SLR L N + + NAF
Sbjct: 362 NLLEDLPSFS---VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 418
Query: 301 ANNTELEYLDLSNNNIASLRYDTFRGLKMLK----HLDLSWNEIAVIPEDSLLEMP 352
+ L LDLS+N ++S GL LK H S PE ++EMP
Sbjct: 419 STLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMP 474
Score = 46.4 bits (105), Expect = 4e-04
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 14/175 (8%)
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
++Q+ PD L LE L L+ S P V +L++LDLS+N + +
Sbjct: 315 ASQITEFPD--LTGTANLESLTLTGAQISSL----PQTVCNQLPNLQVLDLSYNLLEDLP 368
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + + L+ + L H EI I + L+++R L L +N + I S+L
Sbjct: 369 SFS-----VCQKLQKIDLRHNEIYEIKVDT-FQQLLSLRSLNLAWNKIAIIHPNAFSTLP 422
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
SL + L+ + L LTHLK++ N+ L+ S+ N LK I++ Y
Sbjct: 423 SLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENF--PELKVIEMPY 475
Score = 35.5 bits (78), Expect = 0.70
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 1/53 (1%)
Query: 62 LQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEV 113
L + LN++ N+ P + S L +L+ LD+SSN L P L+ LT L++
Sbjct: 398 LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKL 450
>BC126171-1|AAI26172.1| 1119|Homo sapiens leucine-rich repeats and
immunoglobulin-like domains 3 protein.
Length = 1119
Score = 88.6 bits (210), Expect = 7e-17
Identities = 94/350 (26%), Positives = 164/350 (46%), Gaps = 21/350 (6%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
LDLS N+ + + L SL + L++ E+ +I P+S NI +L L N +
Sbjct: 79 LDLSHNRLSFIKASSMSHL---QSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRI 133
Query: 202 LRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLT--HLKMSNNYRLELASSANNLFS 258
+ I +SL +L+S N +EL P+L +L +++N + + +
Sbjct: 134 VEILPEHLKEFQSL--ETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLA 191
Query: 259 QSLKYIDISYCNI--LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+L + ++ I + P + P L+ LN N ++ ++ F L+ L + N +
Sbjct: 192 NTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 251
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLR---SM 373
L F GL ++ L L N + I + L + L +L LS+N ++R+
Sbjct: 252 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 311
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
++ LD++ L+ + S GL + L + N +SYI D ++LK L+L N I
Sbjct: 312 KLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI 371
Query: 432 S-SINNL--TFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
S +I ++ F L++L L + GNR I +++F + LE LDLSDN
Sbjct: 372 SWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDA-LEHLDLSDN 420
Score = 82.2 bits (194), Expect = 6e-15
Identities = 101/408 (24%), Positives = 185/408 (45%), Gaps = 25/408 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
CRC D +DCSR+ L +P L V +L++S+N + S+S L +L + +++N
Sbjct: 51 CRCLGDL--LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNN 108
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+L+ +P+ + + +L+L+ N + + P + L L+ LDLS N +
Sbjct: 109 ELETIPNLGPVSAN-ITLLSLAGNRI---VEILP-EHLKEFQSLETLDLSSNNISEL--- 160
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISS--SL 212
Q L+ L L+ + S+ L N + VLKLN N + I + L
Sbjct: 161 --QTAFPALQLKYLYLNSNRVTSME-PGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQL 217
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN-NLFSQSLKYID-ISYCN 270
+ L ++ ++ +++ L +L LKM N +L A L + + +D +
Sbjct: 218 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 277
Query: 271 ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
I + L G L++ L+ N + + +A+ +L LDL+ N+++ L +F GL +L
Sbjct: 278 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 337
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD------MSSCE 384
L + N ++ I + + + SL L L N +S + + + LD +
Sbjct: 338 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNR 397
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRIS 432
+ +I K + GL ++ LDLS N + + + S K L+ N S
Sbjct: 398 IRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSS 445
Score = 71.3 bits (167), Expect = 1e-11
Identities = 91/350 (26%), Positives = 156/350 (44%), Gaps = 35/350 (10%)
Query: 45 DIDCSRRGLTDIPN--GLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLP 101
++ + L IPN + +T L+++ N + PE L +L LD+SSN + L
Sbjct: 102 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 161
Query: 102 D-------NALYNLTALEVLNLSRNYFDSWLN------LNPNDV-LLPATHLKI-----L 142
LY L + V ++ YFD+ N LN N + +P K+ L
Sbjct: 162 TAFPALQLKYLY-LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL 220
Query: 143 DLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
+L+ NK + + L Q L +L++L + + + + GL N+ +L+L+ N L
Sbjct: 221 ELNRNKIKNVDGLTFQGL---GALKSLKMQRNGVTKLMDGA-FWGLSNMEILQLDHNNLT 276
Query: 203 RIQN--LISS-SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--RLELASSANNLF 257
I L L+ L +S + ++ + F L+ L ++ N+ RL+ +S
Sbjct: 277 EITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL 336
Query: 258 SQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRY-LE--SNAFANNTELEYLDLSNN 314
+L + I +G SL+ L +N + + +E + AF+ +L L L N
Sbjct: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 396
Query: 315 NIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
I S+ F GL L+HLDLS N I + ++ +M L QL L+ + L
Sbjct: 397 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 35.5 bits (78), Expect = 0.70
Identities = 29/80 (36%), Positives = 42/80 (52%), Gaps = 3/80 (3%)
Query: 357 LKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPD-- 414
L SR L+R+ V LD+S L+ I S+ LQS+ E+ L+ N L IP+
Sbjct: 58 LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG 117
Query: 415 SISSNTLKYLNLNYNRISSI 434
+S+N + L+L NRI I
Sbjct: 118 PVSAN-ITLLSLAGNRIVEI 136
>BC126169-1|AAI26170.1| 1119|Homo sapiens leucine-rich repeats and
immunoglobulin-like domains 3 protein.
Length = 1119
Score = 88.6 bits (210), Expect = 7e-17
Identities = 94/350 (26%), Positives = 164/350 (46%), Gaps = 21/350 (6%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
LDLS N+ + + L SL + L++ E+ +I P+S NI +L L N +
Sbjct: 79 LDLSHNRLSFIKASSMSHL---QSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRI 133
Query: 202 LRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLT--HLKMSNNYRLELASSANNLFS 258
+ I +SL +L+S N +EL P+L +L +++N + + +
Sbjct: 134 VEILPEHLKEFQSL--ETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLA 191
Query: 259 QSLKYIDISYCNI--LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+L + ++ I + P + P L+ LN N ++ ++ F L+ L + N +
Sbjct: 192 NTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 251
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLR---SM 373
L F GL ++ L L N + I + L + L +L LS+N ++R+
Sbjct: 252 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 311
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
++ LD++ L+ + S GL + L + N +SYI D ++LK L+L N I
Sbjct: 312 KLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI 371
Query: 432 S-SINNL--TFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
S +I ++ F L++L L + GNR I +++F + LE LDLSDN
Sbjct: 372 SWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDA-LEHLDLSDN 420
Score = 82.2 bits (194), Expect = 6e-15
Identities = 101/408 (24%), Positives = 185/408 (45%), Gaps = 25/408 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
CRC D +DCSR+ L +P L V +L++S+N + S+S L +L + +++N
Sbjct: 51 CRCLGDL--LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNN 108
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+L+ +P+ + + +L+L+ N + + P + L L+ LDLS N +
Sbjct: 109 ELETIPNLGPVSAN-ITLLSLAGNRI---VEILP-EHLKEFQSLETLDLSSNNISEL--- 160
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISS--SL 212
Q L+ L L+ + S+ L N + VLKLN N + I + L
Sbjct: 161 --QTAFPALQLKYLYLNSNRVTSME-PGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQL 217
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN-NLFSQSLKYID-ISYCN 270
+ L ++ ++ +++ L +L LKM N +L A L + + +D +
Sbjct: 218 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 277
Query: 271 ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
I + L G L++ L+ N + + +A+ +L LDL+ N+++ L +F GL +L
Sbjct: 278 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 337
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD------MSSCE 384
L + N ++ I + + + SL L L N +S + + + LD +
Sbjct: 338 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNR 397
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRIS 432
+ +I K + GL ++ LDLS N + + + S K L+ N S
Sbjct: 398 IRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSS 445
Score = 71.3 bits (167), Expect = 1e-11
Identities = 91/350 (26%), Positives = 156/350 (44%), Gaps = 35/350 (10%)
Query: 45 DIDCSRRGLTDIPN--GLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLP 101
++ + L IPN + +T L+++ N + PE L +L LD+SSN + L
Sbjct: 102 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 161
Query: 102 D-------NALYNLTALEVLNLSRNYFDSWLN------LNPNDV-LLPATHLKI-----L 142
LY L + V ++ YFD+ N LN N + +P K+ L
Sbjct: 162 TAFPALQLKYLY-LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL 220
Query: 143 DLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
+L+ NK + + L Q L +L++L + + + + GL N+ +L+L+ N L
Sbjct: 221 ELNRNKIKNVDGLTFQGL---GALKSLKMQRNGVTKLMDGA-FWGLSNMEILQLDHNNLT 276
Query: 203 RIQN--LISS-SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--RLELASSANNLF 257
I L L+ L +S + ++ + F L+ L ++ N+ RL+ +S
Sbjct: 277 EITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL 336
Query: 258 SQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRY-LE--SNAFANNTELEYLDLSNN 314
+L + I +G SL+ L +N + + +E + AF+ +L L L N
Sbjct: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 396
Query: 315 NIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
I S+ F GL L+HLDLS N I + ++ +M L QL L+ + L
Sbjct: 397 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 35.5 bits (78), Expect = 0.70
Identities = 29/80 (36%), Positives = 42/80 (52%), Gaps = 3/80 (3%)
Query: 357 LKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPD-- 414
L SR L+R+ V LD+S L+ I S+ LQS+ E+ L+ N L IP+
Sbjct: 58 LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG 117
Query: 415 SISSNTLKYLNLNYNRISSI 434
+S+N + L+L NRI I
Sbjct: 118 PVSAN-ITLLSLAGNRIVEI 136
>AY505340-1|AAR98629.1| 1119|Homo sapiens leucine-rich and
immunoglobulin-like domains 3 protein.
Length = 1119
Score = 88.6 bits (210), Expect = 7e-17
Identities = 94/350 (26%), Positives = 164/350 (46%), Gaps = 21/350 (6%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
LDLS N+ + + L SL + L++ E+ +I P+S NI +L L N +
Sbjct: 79 LDLSHNRLSFIKASSMSHL---QSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRI 133
Query: 202 LRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLT--HLKMSNNYRLELASSANNLFS 258
+ I +SL +L+S N +EL P+L +L +++N + + +
Sbjct: 134 VEILPEHLKEFQSL--ETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLA 191
Query: 259 QSLKYIDISYCNI--LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+L + ++ I + P + P L+ LN N ++ ++ F L+ L + N +
Sbjct: 192 NTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 251
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLR---SM 373
L F GL ++ L L N + I + L + L +L LS+N ++R+
Sbjct: 252 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 311
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
++ LD++ L+ + S GL + L + N +SYI D ++LK L+L N I
Sbjct: 312 KLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI 371
Query: 432 S-SINNL--TFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
S +I ++ F L++L L + GNR I +++F + LE LDLSDN
Sbjct: 372 SWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDA-LEHLDLSDN 420
Score = 82.2 bits (194), Expect = 6e-15
Identities = 101/408 (24%), Positives = 185/408 (45%), Gaps = 25/408 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
CRC D +DCSR+ L +P L V +L++S+N + S+S L +L + +++N
Sbjct: 51 CRCLGDL--LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNN 108
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+L+ +P+ + + +L+L+ N + + P + L L+ LDLS N +
Sbjct: 109 ELETIPNLGPVSAN-ITLLSLAGNRI---VEILP-EHLKEFQSLETLDLSSNNISEL--- 160
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISS--SL 212
Q L+ L L+ + S+ L N + VLKLN N + I + L
Sbjct: 161 --QTAFPALQLKYLYLNSNRVTSME-PGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQL 217
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN-NLFSQSLKYID-ISYCN 270
+ L ++ ++ +++ L +L LKM N +L A L + + +D +
Sbjct: 218 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 277
Query: 271 ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
I + L G L++ L+ N + + +A+ +L LDL+ N+++ L +F GL +L
Sbjct: 278 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 337
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD------MSSCE 384
L + N ++ I + + + SL L L N +S + + + LD +
Sbjct: 338 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNR 397
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRIS 432
+ +I K + GL ++ LDLS N + + + S K L+ N S
Sbjct: 398 IRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSS 445
Score = 71.3 bits (167), Expect = 1e-11
Identities = 91/350 (26%), Positives = 156/350 (44%), Gaps = 35/350 (10%)
Query: 45 DIDCSRRGLTDIPN--GLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLP 101
++ + L IPN + +T L+++ N + PE L +L LD+SSN + L
Sbjct: 102 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 161
Query: 102 D-------NALYNLTALEVLNLSRNYFDSWLN------LNPNDV-LLPATHLKI-----L 142
LY L + V ++ YFD+ N LN N + +P K+ L
Sbjct: 162 TAFPALQLKYLY-LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL 220
Query: 143 DLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
+L+ NK + + L Q L +L++L + + + + GL N+ +L+L+ N L
Sbjct: 221 ELNRNKIKNVDGLTFQGL---GALKSLKMQRNGVTKLMDGA-FWGLSNMEILQLDHNNLT 276
Query: 203 RIQN--LISS-SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--RLELASSANNLF 257
I L L+ L +S + ++ + F L+ L ++ N+ RL+ +S
Sbjct: 277 EITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL 336
Query: 258 SQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRY-LE--SNAFANNTELEYLDLSNN 314
+L + I +G SL+ L +N + + +E + AF+ +L L L N
Sbjct: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 396
Query: 315 NIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
I S+ F GL L+HLDLS N I + ++ +M L QL L+ + L
Sbjct: 397 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 35.5 bits (78), Expect = 0.70
Identities = 29/80 (36%), Positives = 42/80 (52%), Gaps = 3/80 (3%)
Query: 357 LKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPD-- 414
L SR L+R+ V LD+S L+ I S+ LQS+ E+ L+ N L IP+
Sbjct: 58 LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG 117
Query: 415 SISSNTLKYLNLNYNRISSI 434
+S+N + L+L NRI I
Sbjct: 118 PVSAN-ITLLSLAGNRIVEI 136
>AY358295-1|AAQ88662.1| 1059|Homo sapiens SAPS287 protein.
Length = 1059
Score = 88.6 bits (210), Expect = 7e-17
Identities = 102/413 (24%), Positives = 185/413 (44%), Gaps = 39/413 (9%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
SL L ++ D+S N+L + +++ +L +L + L+ N ++ NL P + ++
Sbjct: 9 SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGP-----VSANI 63
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+L L+ N+ + + + L SLETL L I+ + P + ++ L LN N
Sbjct: 64 TLLSLAGNR---IVEILPEHLKEFQSLETLDLSSNNISELQTAFP---ALQLKYLYLNSN 117
Query: 200 PLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ 259
+ ++ +L + + + LN N + +P K+ LEL +
Sbjct: 118 RVTSMEPGYFDNLANTLL----VLKLNRNRISAIPP-KMFKLPQLQHLELNRN------- 165
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
+K +D +G +L+ + N V L AF + +E L L +NN+ +
Sbjct: 166 KIKNVD-------GLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI 218
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD 379
GL ML+ L LS N I I D+ L++L L+ N+LSR+ + +++L+
Sbjct: 219 TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN 278
Query: 380 ---MSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-----NTLKYLNLNYNRI 431
+ + ++ I + GL S+ LDL N +S+ + ++ + L+ L L NRI
Sbjct: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
Query: 432 SSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
SI F L+ L L + N M + + F L++L L+ + CDC
Sbjct: 339 RSITKKAFTGLDALEHLDLSDNAI-MSLQGNAFSQMKKLQQLHLNTSSLLCDC 390
Score = 71.3 bits (167), Expect = 1e-11
Identities = 91/350 (26%), Positives = 156/350 (44%), Gaps = 35/350 (10%)
Query: 45 DIDCSRRGLTDIPN--GLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLP 101
++ + L IPN + +T L+++ N + PE L +L LD+SSN + L
Sbjct: 42 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 101
Query: 102 D-------NALYNLTALEVLNLSRNYFDSWLN------LNPNDV-LLPATHLKI-----L 142
LY L + V ++ YFD+ N LN N + +P K+ L
Sbjct: 102 TAFPALQLKYLY-LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL 160
Query: 143 DLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
+L+ NK + + L Q L +L++L + + + + GL N+ +L+L+ N L
Sbjct: 161 ELNRNKIKNVDGLTFQGL---GALKSLKMQRNGVTKLMDGA-FWGLSNMEILQLDHNNLT 216
Query: 203 RIQN--LISS-SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--RLELASSANNLF 257
I L L+ L +S + ++ + F L+ L ++ N+ RL+ +S
Sbjct: 217 EITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL 276
Query: 258 SQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRY-LE--SNAFANNTELEYLDLSNN 314
+L + I +G SL+ L +N + + +E + AF+ +L L L N
Sbjct: 277 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 336
Query: 315 NIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
I S+ F GL L+HLDLS N I + ++ +M L QL L+ + L
Sbjct: 337 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
>AY358288-1|AAQ88655.1| 1119|Homo sapiens SAPS287 protein.
Length = 1119
Score = 88.6 bits (210), Expect = 7e-17
Identities = 94/350 (26%), Positives = 164/350 (46%), Gaps = 21/350 (6%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
LDLS N+ + + L SL + L++ E+ +I P+S NI +L L N +
Sbjct: 79 LDLSHNRLSFIKASSMSHL---QSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRI 133
Query: 202 LRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLT--HLKMSNNYRLELASSANNLFS 258
+ I +SL +L+S N +EL P+L +L +++N + + +
Sbjct: 134 VEILPEHLKEFQSL--ETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLA 191
Query: 259 QSLKYIDISYCNI--LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+L + ++ I + P + P L+ LN N ++ ++ F L+ L + N +
Sbjct: 192 NTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 251
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLR---SM 373
L F GL ++ L L N + I + L + L +L LS+N ++R+
Sbjct: 252 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 311
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
++ LD++ L+ + S GL + L + N +SYI D ++LK L+L N I
Sbjct: 312 KLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI 371
Query: 432 S-SINNL--TFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
S +I ++ F L++L L + GNR I +++F + LE LDLSDN
Sbjct: 372 SWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDA-LEHLDLSDN 420
Score = 82.2 bits (194), Expect = 6e-15
Identities = 101/408 (24%), Positives = 185/408 (45%), Gaps = 25/408 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
CRC D +DCSR+ L +P L V +L++S+N + S+S L +L + +++N
Sbjct: 51 CRCLGDL--LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNN 108
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+L+ +P+ + + +L+L+ N + + P + L L+ LDLS N +
Sbjct: 109 ELETIPNLGPVSAN-ITLLSLAGNRI---VEILP-EHLKEFQSLETLDLSSNNISEL--- 160
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISS--SL 212
Q L+ L L+ + S+ L N + VLKLN N + I + L
Sbjct: 161 --QTAFPALQLKYLYLNSNRVTSME-PGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQL 217
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN-NLFSQSLKYID-ISYCN 270
+ L ++ ++ +++ L +L LKM N +L A L + + +D +
Sbjct: 218 QHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE 277
Query: 271 ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
I + L G L++ L+ N + + +A+ +L LDL+ N+++ L +F GL +L
Sbjct: 278 ITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLL 337
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD------MSSCE 384
L + N ++ I + + + SL L L N +S + + + LD +
Sbjct: 338 NTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNR 397
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRIS 432
+ +I K + GL ++ LDLS N + + + S K L+ N S
Sbjct: 398 IRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSS 445
Score = 71.3 bits (167), Expect = 1e-11
Identities = 91/350 (26%), Positives = 156/350 (44%), Gaps = 35/350 (10%)
Query: 45 DIDCSRRGLTDIPN--GLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLP 101
++ + L IPN + +T L+++ N + PE L +L LD+SSN + L
Sbjct: 102 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ 161
Query: 102 D-------NALYNLTALEVLNLSRNYFDSWLN------LNPNDV-LLPATHLKI-----L 142
LY L + V ++ YFD+ N LN N + +P K+ L
Sbjct: 162 TAFPALQLKYLY-LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL 220
Query: 143 DLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
+L+ NK + + L Q L +L++L + + + + GL N+ +L+L+ N L
Sbjct: 221 ELNRNKIKNVDGLTFQGL---GALKSLKMQRNGVTKLMDGA-FWGLSNMEILQLDHNNLT 276
Query: 203 RIQN--LISS-SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--RLELASSANNLF 257
I L L+ L +S + ++ + F L+ L ++ N+ RL+ +S
Sbjct: 277 EITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL 336
Query: 258 SQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRY-LE--SNAFANNTELEYLDLSNN 314
+L + I +G SL+ L +N + + +E + AF+ +L L L N
Sbjct: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 396
Query: 315 NIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
I S+ F GL L+HLDLS N I + ++ +M L QL L+ + L
Sbjct: 397 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 35.5 bits (78), Expect = 0.70
Identities = 29/80 (36%), Positives = 42/80 (52%), Gaps = 3/80 (3%)
Query: 357 LKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPD-- 414
L SR L+R+ V LD+S L+ I S+ LQS+ E+ L+ N L IP+
Sbjct: 58 LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG 117
Query: 415 SISSNTLKYLNLNYNRISSI 434
+S+N + L+L NRI I
Sbjct: 118 PVSAN-ITLLSLAGNRIVEI 136
>AL356953-1|CAI15927.1| 967|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 6 protein.
Length = 967
Score = 88.2 bits (209), Expect = 9e-17
Identities = 104/408 (25%), Positives = 175/408 (42%), Gaps = 19/408 (4%)
Query: 37 CRCNLD--KTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDIS 93
C C D DCS GL+ +P L L++S N T+ P L L L +S
Sbjct: 39 CHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLS 98
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
N L +P A L +L++L L N L P + L L+ L L N +
Sbjct: 99 GNHLSHIPGQAFSGLYSLKILMLQNNQ----LGGIPAEALWELPSLQSLRLDANLISLVP 154
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + L SL L LD + I R+ L+ L ++ + L N + I + +L
Sbjct: 155 ERSFEGL---SSLRHLWLDDNALTEIPVRA-LNNLPALQAMTLALNRISHIPDYAFQNLT 210
Query: 214 SLFV---SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYC 269
SL V N + L + L +L L ++ N E + L Q L + + +
Sbjct: 211 SLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIK 270
Query: 270 NILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKM 329
I + G P L+ N ++++ +AF +L L L N + + +G
Sbjct: 271 AIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGTTS 329
Query: 330 LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL-RSMSVTILDMSSCELNTI 388
L+ L L+ I ++P ++P L L+LS N + + L R + + + + I
Sbjct: 330 LEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEI 389
Query: 389 GKDSLEGLQSIVELDLSQNLLSYI-PDSISS-NTLKYLNLNYNRISSI 434
G D+ L S+ LDLS N + I P++ S+ ++L L+L N+++++
Sbjct: 390 GADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL 437
Score = 84.2 bits (199), Expect = 2e-15
Identities = 106/384 (27%), Positives = 169/384 (44%), Gaps = 32/384 (8%)
Query: 46 IDCSRRGLTDIPNGLGLQVT---KLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLP 101
+D S LT++ GL + +L +S N + P ++ S L++L L + +NQL G+P
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
AL+ L +L+ L L N ++L P + L+ L L N + A L
Sbjct: 131 AEALWELPSLQSLRLDANL----ISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL- 185
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE 221
P+L+ + L I+ I + L ++ VL L+ N RIQ+L + S L N E
Sbjct: 186 --PALQAMTLALNRISHIPDYA-FQNLTSLVVLHLHNN---RIQHLGTHSFEGL--HNLE 237
Query: 222 LTSLNHNELMFLP-------SLTHLKMSNNYRLELASSA--NNLFSQSLKYIDISYCNIL 272
LN+N+L P L L NN + A N Q++ + D +
Sbjct: 238 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 297
Query: 273 QPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
+ + P L LN M E T LE L L+ I L + L L+
Sbjct: 298 RSAFQYLPKLHTLSLNGAM-DIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRV 356
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIG 389
L+LS N+I +P SL L ++ L N + +G + S+ LD+S + +I
Sbjct: 357 LELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIH 414
Query: 390 KDSLEGLQSIVELDLSQNLLSYIP 413
++ L S+V+LDL+ N L+ +P
Sbjct: 415 PEAFSTLHSLVKLDLTDNQLTTLP 438
Score = 72.1 bits (169), Expect = 7e-12
Identities = 65/251 (25%), Positives = 110/251 (43%), Gaps = 5/251 (1%)
Query: 233 LPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMV 292
L + L M+N L+ + F + L+ +I G SL+ +L +N +
Sbjct: 67 LTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 126
Query: 293 RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP 352
+ + A L+ L L N I+ + +F GL L+HL L N + IP +L +P
Sbjct: 127 GGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP 186
Query: 353 SLTQLKLSRNYLSRVGHLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLL 409
+L + L+ N +S + ++T +L + + + +G S EGL ++ LDL+ N L
Sbjct: 187 ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 246
Query: 410 SYIPDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNP 468
P +I + L+ L + N I +I F L ++ N + RS F P
Sbjct: 247 QEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFV-GRSAFQYLP 305
Query: 469 YLERLDLSDNM 479
L L L+ M
Sbjct: 306 KLHTLSLNGAM 316
Score = 65.7 bits (153), Expect = 6e-10
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 17/298 (5%)
Query: 69 ISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL 127
+ +N T+ P +L+ L L + ++ N++ +PD A NLT+L VL+L N L
Sbjct: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH-LGT 227
Query: 128 NPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSG 187
+ + L +L+ LDL++NK Q +A + L L+ L + I +I ++ +
Sbjct: 228 HSFEGL---HNLETLDLNYNKLQEFP-VAIRTL---GRLQELGFHNNNIKAIPEKAFMGN 280
Query: 188 LINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
+ ++ + NP+ + L L + +++ E L T L++ R
Sbjct: 281 PL-LQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRA 338
Query: 248 ELASSANNLFSQ--SLKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNT 304
+ + + Q L+ +++S+ I + P+L L + L HN + + ++ F+ +
Sbjct: 339 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLS 398
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
L+ LDLS N I S+ + F L L LDL+ N++ +P L + L LKL N
Sbjct: 399 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 453
Score = 60.9 bits (141), Expect = 2e-08
Identities = 68/271 (25%), Positives = 116/271 (42%), Gaps = 12/271 (4%)
Query: 194 LKLNFNPLLRIQNLISS---SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELA 250
L+L+ N L I S SL+ L + N +L + L LPSL L++ N + L
Sbjct: 95 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANL-ISLV 153
Query: 251 SSANNLFSQSLKYI---DISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
+ SL+++ D + I L P+L+ L N + ++ AF N T L
Sbjct: 154 PERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLV 213
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L NN I L +F GL L+ LDL++N++ P ++ + L +L N + +
Sbjct: 214 VLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAI 272
Query: 368 GHLRSMSVTILD---MSSCELNTIGKDSLEGLQSIVELDLSQNL-LSYIPDSISSNTLKY 423
M +L + +G+ + + L + L L+ + + PD + +L+
Sbjct: 273 PEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEI 332
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNR 454
L L I + + L RL L + N+
Sbjct: 333 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 363
Score = 49.6 bits (113), Expect = 4e-05
Identities = 52/188 (27%), Positives = 89/188 (47%), Gaps = 16/188 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
L +LH L +L+ + ++ PD L T+LE+L L+R + + L P+ + L+
Sbjct: 304 LPKLHTL-SLN-GAMDIQEFPD--LKGTTSLEILTLTR----AGIRLLPSGMCQQLPRLR 355
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
+L+LS N+ + + +L + LE + L H I I G S L +++ L L++N
Sbjct: 356 VLELSHNQIEELPSLHRCQ-----KLEEIGLQHNRIWEI-GADTFSQLSSLQALDLSWNA 409
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
+ I S+L SL + L L L L HLK+ N L A S ++
Sbjct: 410 IRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF--PK 467
Query: 261 LKYIDISY 268
L+ +++ Y
Sbjct: 468 LRILEVPY 475
>BC094737-1|AAH94737.1| 904|Homo sapiens toll-like receptor 3
protein.
Length = 904
Score = 87.8 bits (208), Expect = 1e-16
Identities = 131/501 (26%), Positives = 218/501 (43%), Gaps = 73/501 (14%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQL-KGLPDNALYNLTALEVLNLSRNYFDS 123
KL +S+N+ +F P + L L +++ QL L + L + NLS +
Sbjct: 201 KLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
Query: 124 WLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRS 183
N + L T+L +LDLS+N +GN + L P LE L++ I + S
Sbjct: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWL---PQLEYFFLEYNNIQHLFSHS 317
Query: 184 PLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L GL N+R L L S +S L ++ +L L HL M +
Sbjct: 318 -LHGLFNVRYLNLK------------RSFTKQSISLASLPKIDDFSFQWLKCLEHLNMED 364
Query: 244 NYRLELASSANNLFSQ--SLKYIDIS--YCNILQPNLKGFPSLRKA---ILN--HNMVRY 294
N ++ +N+F+ +LKY+ +S + ++ + F SL + ILN N +
Sbjct: 365 N---DIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISK 421
Query: 295 LESNAFANNTELEYLDLSNNNIAS-LRYDTFRGLKML--------KHLDLSWNEIAVIPE 345
+ES+AF+ LE LDL N I L +RGL+ + K+L L+ N A++P
Sbjct: 422 IESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
Query: 346 DSLLEM-----------PS-------LTQLKLSRNYLSRVGH--LRSMS-VTILDMSSCE 384
L + PS LT L LS N ++ + L + + ILD+
Sbjct: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
Query: 385 LNTIGKDS--------LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSI 434
L + K + L+GL + L+L N + IP + + LK ++L N ++++
Sbjct: 542 LARLWKHANPGGPIYFLKGLSHLHILNLESNGFNEIPVEVFKDLFELKIIDLGLNNLNTL 601
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F L SL++ N T + ++ F + L LD+ N + C C E++ F +
Sbjct: 602 PASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTC--ESIAWFVN 659
Query: 495 FVT-LEPNKKEESFNLICNSP 514
++ N E S + +CN+P
Sbjct: 660 WINETHTNIPELSSHYLCNTP 680
Score = 81.4 bits (192), Expect = 1e-14
Identities = 115/453 (25%), Positives = 194/453 (42%), Gaps = 50/453 (11%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C + DCS LT +P+ L +T LN+++N+ + P + +R L +LD+ N
Sbjct: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ L L L+VLNL N L+ + T+L L L N Q +
Sbjct: 87 ISKLEPELCQKLPMLKVLNLQHNE----LSQLSDKTFAFCTNLTELHLMSNSIQ---KIK 139
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
N + + +L TL L H ++S + + L N++ L L+ N +IQ L S L
Sbjct: 140 NNPFVKQKNLITLDLSHNGLSSTKLGTQVQ-LENLQELLLSNN---KIQALKSEELDIFA 195
Query: 217 VSNCELTSLNHNELM-FLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQ 273
S+ + L+ N++ F P H + LF L + + S L
Sbjct: 196 NSSLKKLELSSNQIKEFSPGCFH-------------AIGRLFGLFLNNVQLGPSLTEKLC 242
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANN--TELEYLDLSNNNIASLRYDTFRGLKMLK 331
L S+R L+++ + + F T L LDLS NN+ + D+F L L+
Sbjct: 243 LELAN-TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLE 301
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKD 391
+ L +N I + SL + ++ L L R++ T +S L I
Sbjct: 302 YFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSF------------TKQSISLASLPKIDDF 349
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNL--NYNRISSINNLTFFML--NRL 445
S + L+ + L++ N + I ++ + LKYL+L ++ + ++ N TF L + L
Sbjct: 350 SFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 409
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L++ N+ + I F +LE LDL N
Sbjct: 410 HILNLTKNKISKI-ESDAFSWLGHLEVLDLGLN 441
Score = 64.5 bits (150), Expect = 1e-09
Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 22/283 (7%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-----SLTHLKMSNNYRLELASSANN 255
LL L +SS VS+ E+ +H +L +P ++T L +++N L ++
Sbjct: 14 LLPFGMLCASSTTKCTVSH-EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFT 72
Query: 256 LFSQSLKYIDISYCNI--LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
+SQ L +D+ + I L+P L + P L+ L HN + L FA T L L L
Sbjct: 73 RYSQ-LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLM 131
Query: 313 NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL-----SRV 367
+N+I ++ + F K L LDLS N ++ + +++ +L +L LS N + +
Sbjct: 132 SNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEEL 191
Query: 368 GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL-----DLSQNLLSYIPDSISSNTLK 422
+ S+ L++SS ++ + + L L +L + +++ +++
Sbjct: 192 DIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIR 251
Query: 423 YLNLNYNRISSINNLTFFML--NRLTSLSVVGNRFTMIWRRSF 463
L+L+ +++S+ +N TF L LT L + N ++ SF
Sbjct: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSF 294
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 6/108 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+ +R +P+ L + ++ + N + + P L NL LD+S+N + + D+ L
Sbjct: 469 LQLTRNSFALVPSLQRLMLRRVALKNVDSS--PSPFQPLRNLTILDLSNNNIANINDDML 526
Query: 106 YNLTALEVLNLSRNYFDS-WLNLNPND---VLLPATHLKILDLSFNKF 149
L LE+L+L N W + NP L +HL IL+L N F
Sbjct: 527 EGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGF 574
>U88879-1|AAC34134.1| 904|Homo sapiens Toll-like receptor 3
protein.
Length = 904
Score = 87.4 bits (207), Expect = 2e-16
Identities = 131/501 (26%), Positives = 217/501 (43%), Gaps = 73/501 (14%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQL-KGLPDNALYNLTALEVLNLSRNYFDS 123
KL +S+N+ +F P + L L +++ QL L + L + NLS +
Sbjct: 201 KLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
Query: 124 WLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRS 183
N + L T+L +LDLS+N +GN + L P LE L++ I + S
Sbjct: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWL---PQLEYFFLEYNNIQHLFSHS 317
Query: 184 PLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L GL N+R L L S +S L ++ +L L HL M +
Sbjct: 318 -LHGLFNVRYLNLK------------RSFTKQSISLASLPKIDDFSFQWLKCLEHLNMED 364
Query: 244 NYRLELASSANNLFSQ--SLKYIDIS--YCNILQPNLKGFPSLRKA---ILN--HNMVRY 294
N ++ +N+F+ +LKY+ +S + ++ + F SL + ILN N +
Sbjct: 365 N---DIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISK 421
Query: 295 LESNAFANNTELEYLDLSNNNIAS-LRYDTFRGLKML--------KHLDLSWNEIAVIPE 345
+ES+AF+ LE LDL N I L +RGL+ + K+L L+ N A++P
Sbjct: 422 IESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
Query: 346 DSLLEM-----------PS-------LTQLKLSRNYLSRVGH--LRSMS-VTILDMSSCE 384
L + PS LT L LS N ++ + L + + ILD+
Sbjct: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
Query: 385 LNTIGKDS--------LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSI 434
L + K + L+GL + L+L N IP + + LK ++L N ++++
Sbjct: 542 LARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTL 601
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F L SL++ N T + ++ F + L LD+ N + C C E++ F +
Sbjct: 602 PASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTC--ESIAWFVN 659
Query: 495 FVT-LEPNKKEESFNLICNSP 514
++ N E S + +CN+P
Sbjct: 660 WINETHTNIPELSSHYLCNTP 680
Score = 81.4 bits (192), Expect = 1e-14
Identities = 115/453 (25%), Positives = 194/453 (42%), Gaps = 50/453 (11%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C + DCS LT +P+ L +T LN+++N+ + P + +R L +LD+ N
Sbjct: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ L L L+VLNL N L+ + T+L L L N Q +
Sbjct: 87 ISKLEPELCQKLPMLKVLNLQHNE----LSQLSDKTFAFCTNLTELHLMSNSIQ---KIK 139
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
N + + +L TL L H ++S + + L N++ L L+ N +IQ L S L
Sbjct: 140 NNPFVKQKNLITLDLSHNGLSSTKLGTQVQ-LENLQELLLSNN---KIQALKSEELDIFA 195
Query: 217 VSNCELTSLNHNELM-FLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQ 273
S+ + L+ N++ F P H + LF L + + S L
Sbjct: 196 NSSLKKLELSSNQIKEFSPGCFH-------------AIGRLFGLFLNNVQLGPSLTEKLC 242
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANN--TELEYLDLSNNNIASLRYDTFRGLKMLK 331
L S+R L+++ + + F T L LDLS NN+ + D+F L L+
Sbjct: 243 LELAN-TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLE 301
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKD 391
+ L +N I + SL + ++ L L R++ T +S L I
Sbjct: 302 YFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSF------------TKQSISLASLPKIDDF 349
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNL--NYNRISSINNLTFFML--NRL 445
S + L+ + L++ N + I ++ + LKYL+L ++ + ++ N TF L + L
Sbjct: 350 SFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 409
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L++ N+ + I F +LE LDL N
Sbjct: 410 HILNLTKNKISKI-ESDAFSWLGHLEVLDLGLN 441
Score = 64.5 bits (150), Expect = 1e-09
Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 22/283 (7%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-----SLTHLKMSNNYRLELASSANN 255
LL L +SS VS+ E+ +H +L +P ++T L +++N L ++
Sbjct: 14 LLPFGMLCASSTTKCTVSH-EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFT 72
Query: 256 LFSQSLKYIDISYCNI--LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
+SQ L +D+ + I L+P L + P L+ L HN + L FA T L L L
Sbjct: 73 RYSQ-LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLM 131
Query: 313 NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL-----SRV 367
+N+I ++ + F K L LDLS N ++ + +++ +L +L LS N + +
Sbjct: 132 SNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEEL 191
Query: 368 GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL-----DLSQNLLSYIPDSISSNTLK 422
+ S+ L++SS ++ + + L L +L + +++ +++
Sbjct: 192 DIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIR 251
Query: 423 YLNLNYNRISSINNLTFFML--NRLTSLSVVGNRFTMIWRRSF 463
L+L+ +++S+ +N TF L LT L + N ++ SF
Sbjct: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSF 294
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 6/108 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+ +R +P+ L + ++ + N + + P L NL LD+S+N + + D+ L
Sbjct: 469 LQLTRNSFALVPSLQRLMLRRVALKNVDSS--PSPFQPLRNLTILDLSNNNIANINDDML 526
Query: 106 YNLTALEVLNLSRNYFDS-WLNLNPND---VLLPATHLKILDLSFNKF 149
L LE+L+L N W + NP L +HL IL+L N F
Sbjct: 527 EGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGF 574
>DQ445682-1|ABE01399.1| 904|Homo sapiens Toll-like receptor 3
isoform NT2-N protein.
Length = 904
Score = 87.4 bits (207), Expect = 2e-16
Identities = 131/501 (26%), Positives = 217/501 (43%), Gaps = 73/501 (14%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQL-KGLPDNALYNLTALEVLNLSRNYFDS 123
KL +S+N+ +F P + L L +++ QL L + L + NLS +
Sbjct: 201 KLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
Query: 124 WLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRS 183
N + L T+L +LDLS+N +GN + L P LE L++ I + S
Sbjct: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWL---PQLEYFFLEYNNIQHLFSHS 317
Query: 184 PLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L GL N+R L L S +S L ++ +L L HL M +
Sbjct: 318 -LHGLFNVRYLNLK------------RSFTKQSISLASLPKIDDFSFQWLKCLEHLNMED 364
Query: 244 NYRLELASSANNLFSQ--SLKYIDIS--YCNILQPNLKGFPSLRKA---ILN--HNMVRY 294
N ++ +N+F+ +LKY+ +S + ++ + F SL + ILN N +
Sbjct: 365 N---DIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISK 421
Query: 295 LESNAFANNTELEYLDLSNNNIAS-LRYDTFRGLKML--------KHLDLSWNEIAVIPE 345
+ES+AF+ LE LDL N I L +RGL+ + K+L L+ N A++P
Sbjct: 422 IESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
Query: 346 DSLLEM-----------PS-------LTQLKLSRNYLSRVGH--LRSMS-VTILDMSSCE 384
L + PS LT L LS N ++ + L + + ILD+
Sbjct: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
Query: 385 LNTIGKDS--------LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSI 434
L + K + L+GL + L+L N IP + + LK ++L N ++++
Sbjct: 542 LARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTL 601
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F L SL++ N T + ++ F + L LD+ N + C C E++ F +
Sbjct: 602 PASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTC--ESIAWFVN 659
Query: 495 FVT-LEPNKKEESFNLICNSP 514
++ N E S + +CN+P
Sbjct: 660 WINETHTNIPELSSHYLCNTP 680
Score = 81.4 bits (192), Expect = 1e-14
Identities = 115/453 (25%), Positives = 194/453 (42%), Gaps = 50/453 (11%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C + DCS LT +P+ L +T LN+++N+ + P + +R L +LD+ N
Sbjct: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ L L L+VLNL N L+ + T+L L L N Q +
Sbjct: 87 ISKLEPELCQKLPMLKVLNLQHNE----LSQLSDKTFAFCTNLTELHLMSNSIQ---KIK 139
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
N + + +L TL L H ++S + + L N++ L L+ N +IQ L S L
Sbjct: 140 NNPFVKQKNLITLDLSHNGLSSTKLGTQVQ-LENLQELLLSNN---KIQALKSEELDIFA 195
Query: 217 VSNCELTSLNHNELM-FLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQ 273
S+ + L+ N++ F P H + LF L + + S L
Sbjct: 196 NSSLKKLELSSNQIKEFSPGCFH-------------AIGRLFGLFLNNVQLGPSLTEKLC 242
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANN--TELEYLDLSNNNIASLRYDTFRGLKMLK 331
L S+R L+++ + + F T L LDLS NN+ + D+F L L+
Sbjct: 243 LELAN-TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLE 301
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKD 391
+ L +N I + SL + ++ L L R++ T +S L I
Sbjct: 302 YFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSF------------TKQSISLASLPKIDDF 349
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNL--NYNRISSINNLTFFML--NRL 445
S + L+ + L++ N + I ++ + LKYL+L ++ + ++ N TF L + L
Sbjct: 350 SFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 409
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L++ N+ + I F +LE LDL N
Sbjct: 410 HILNLTKNKISKI-ESDAFSWLGHLEVLDLGLN 441
Score = 64.5 bits (150), Expect = 1e-09
Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 22/283 (7%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-----SLTHLKMSNNYRLELASSANN 255
LL L +SS VS+ E+ +H +L +P ++T L +++N L ++
Sbjct: 14 LLPFGMLCASSTTKCTVSH-EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFT 72
Query: 256 LFSQSLKYIDISYCNI--LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
+SQ L +D+ + I L+P L + P L+ L HN + L FA T L L L
Sbjct: 73 RYSQ-LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLM 131
Query: 313 NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL-----SRV 367
+N+I ++ + F K L LDLS N ++ + +++ +L +L LS N + +
Sbjct: 132 SNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEEL 191
Query: 368 GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL-----DLSQNLLSYIPDSISSNTLK 422
+ S+ L++SS ++ + + L L +L + +++ +++
Sbjct: 192 DIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIR 251
Query: 423 YLNLNYNRISSINNLTFFML--NRLTSLSVVGNRFTMIWRRSF 463
L+L+ +++S+ +N TF L LT L + N ++ SF
Sbjct: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSF 294
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 6/108 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+ +R +P+ L + ++ + N + + P L NL LD+S+N + + D+ L
Sbjct: 469 LQLTRNSFALVPSLQRLMLRRVALKNVDSS--PSPFQPLRNLTILDLSNNNIANINDDML 526
Query: 106 YNLTALEVLNLSRNYFDS-WLNLNPND---VLLPATHLKILDLSFNKF 149
L LE+L+L N W + NP L +HL IL+L N F
Sbjct: 527 EGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGF 574
>BC096335-1|AAH96335.1| 904|Homo sapiens toll-like receptor 3
protein.
Length = 904
Score = 87.4 bits (207), Expect = 2e-16
Identities = 131/501 (26%), Positives = 217/501 (43%), Gaps = 73/501 (14%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQL-KGLPDNALYNLTALEVLNLSRNYFDS 123
KL +S+N+ +F P + L L +++ QL L + L + NLS +
Sbjct: 201 KLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
Query: 124 WLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRS 183
N + L T+L +LDLS+N +GN + L P LE L++ I + S
Sbjct: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWL---PQLEYFFLEYNNIQHLFSHS 317
Query: 184 PLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L GL N+R L L S +S L ++ +L L HL M +
Sbjct: 318 -LHGLFNVRYLNLK------------RSFTKQSISLASLPKIDDFSFQWLKCLEHLNMED 364
Query: 244 NYRLELASSANNLFSQ--SLKYIDIS--YCNILQPNLKGFPSLRKA---ILN--HNMVRY 294
N ++ +N+F+ +LKY+ +S + ++ + F SL + ILN N +
Sbjct: 365 N---DIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISK 421
Query: 295 LESNAFANNTELEYLDLSNNNIAS-LRYDTFRGLKML--------KHLDLSWNEIAVIPE 345
+ES+AF+ LE LDL N I L +RGL+ + K+L L+ N A++P
Sbjct: 422 IESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
Query: 346 DSLLEM-----------PS-------LTQLKLSRNYLSRVGH--LRSMS-VTILDMSSCE 384
L + PS LT L LS N ++ + L + + ILD+
Sbjct: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
Query: 385 LNTIGKDS--------LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSI 434
L + K + L+GL + L+L N IP + + LK ++L N ++++
Sbjct: 542 LARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTL 601
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F L SL++ N T + ++ F + L LD+ N + C C E++ F +
Sbjct: 602 PASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTC--ESIAWFVN 659
Query: 495 FVT-LEPNKKEESFNLICNSP 514
++ N E S + +CN+P
Sbjct: 660 WINETHTNIPELSSHYLCNTP 680
Score = 81.4 bits (192), Expect = 1e-14
Identities = 115/453 (25%), Positives = 194/453 (42%), Gaps = 50/453 (11%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C + DCS LT +P+ L +T LN+++N+ + P + +R L +LD+ N
Sbjct: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ L L L+VLNL N L+ + T+L L L N Q +
Sbjct: 87 ISKLEPELCQKLPMLKVLNLQHNE----LSQLSDKTFAFCTNLTELHLMSNSIQ---KIK 139
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
N + + +L TL L H ++S + + L N++ L L+ N +IQ L S L
Sbjct: 140 NNPFVKQKNLITLDLSHNGLSSTKLGTQVQ-LENLQELLLSNN---KIQALKSEELDIFA 195
Query: 217 VSNCELTSLNHNELM-FLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQ 273
S+ + L+ N++ F P H + LF L + + S L
Sbjct: 196 NSSLKKLELSSNQIKEFSPGCFH-------------AIGRLFGLFLNNVQLGPSLTEKLC 242
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANN--TELEYLDLSNNNIASLRYDTFRGLKMLK 331
L S+R L+++ + + F T L LDLS NN+ + D+F L L+
Sbjct: 243 LELAN-TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLE 301
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKD 391
+ L +N I + SL + ++ L L R++ T +S L I
Sbjct: 302 YFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSF------------TKQSISLASLPKIDDF 349
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNL--NYNRISSINNLTFFML--NRL 445
S + L+ + L++ N + I ++ + LKYL+L ++ + ++ N TF L + L
Sbjct: 350 SFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 409
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L++ N+ + I F +LE LDL N
Sbjct: 410 HILNLTKNKISKI-ESDAFSWLGHLEVLDLGLN 441
Score = 64.5 bits (150), Expect = 1e-09
Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 22/283 (7%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-----SLTHLKMSNNYRLELASSANN 255
LL L +SS VS+ E+ +H +L +P ++T L +++N L ++
Sbjct: 14 LLPFGMLCASSTTKCTVSH-EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFT 72
Query: 256 LFSQSLKYIDISYCNI--LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
+SQ L +D+ + I L+P L + P L+ L HN + L FA T L L L
Sbjct: 73 RYSQ-LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLM 131
Query: 313 NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL-----SRV 367
+N+I ++ + F K L LDLS N ++ + +++ +L +L LS N + +
Sbjct: 132 SNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEEL 191
Query: 368 GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL-----DLSQNLLSYIPDSISSNTLK 422
+ S+ L++SS ++ + + L L +L + +++ +++
Sbjct: 192 DIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIR 251
Query: 423 YLNLNYNRISSINNLTFFML--NRLTSLSVVGNRFTMIWRRSF 463
L+L+ +++S+ +N TF L LT L + N ++ SF
Sbjct: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSF 294
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 6/108 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+ +R +P+ L + ++ + N + + P L NL LD+S+N + + D+ L
Sbjct: 469 LQLTRNSFALVPSLQRLMLRRVALKNVDSS--PSPFQPLRNLTILDLSNNNIANINDDML 526
Query: 106 YNLTALEVLNLSRNYFDS-WLNLNPND---VLLPATHLKILDLSFNKF 149
L LE+L+L N W + NP L +HL IL+L N F
Sbjct: 527 EGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGF 574
>BC096334-1|AAH96334.1| 904|Homo sapiens toll-like receptor 3
protein.
Length = 904
Score = 87.4 bits (207), Expect = 2e-16
Identities = 131/501 (26%), Positives = 217/501 (43%), Gaps = 73/501 (14%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQL-KGLPDNALYNLTALEVLNLSRNYFDS 123
KL +S+N+ +F P + L L +++ QL L + L + NLS +
Sbjct: 201 KLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
Query: 124 WLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRS 183
N + L T+L +LDLS+N +GN + L P LE L++ I + S
Sbjct: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWL---PQLEYFFLEYNNIQHLFSHS 317
Query: 184 PLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L GL N+R L L S +S L ++ +L L HL M +
Sbjct: 318 -LHGLFNVRYLNLK------------RSFTKQSISLASLPKIDDFSFQWLKCLEHLNMED 364
Query: 244 NYRLELASSANNLFSQ--SLKYIDIS--YCNILQPNLKGFPSLRKA---ILN--HNMVRY 294
N ++ +N+F+ +LKY+ +S + ++ + F SL + ILN N +
Sbjct: 365 N---DIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISK 421
Query: 295 LESNAFANNTELEYLDLSNNNIAS-LRYDTFRGLKML--------KHLDLSWNEIAVIPE 345
+ES+AF+ LE LDL N I L +RGL+ + K+L L+ N A++P
Sbjct: 422 IESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
Query: 346 DSLLEM-----------PS-------LTQLKLSRNYLSRVGH--LRSMS-VTILDMSSCE 384
L + PS LT L LS N ++ + L + + ILD+
Sbjct: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
Query: 385 LNTIGKDS--------LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSI 434
L + K + L+GL + L+L N IP + + LK ++L N ++++
Sbjct: 542 LARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTL 601
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F L SL++ N T + ++ F + L LD+ N + C C E++ F +
Sbjct: 602 PASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTC--ESIAWFVN 659
Query: 495 FVT-LEPNKKEESFNLICNSP 514
++ N E S + +CN+P
Sbjct: 660 WINETHTNIPELSSHYLCNTP 680
Score = 81.4 bits (192), Expect = 1e-14
Identities = 115/453 (25%), Positives = 194/453 (42%), Gaps = 50/453 (11%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C + DCS LT +P+ L +T LN+++N+ + P + +R L +LD+ N
Sbjct: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ L L L+VLNL N L+ + T+L L L N Q +
Sbjct: 87 ISKLEPELCQKLPMLKVLNLQHNE----LSQLSDKTFAFCTNLTELHLMSNSIQ---KIK 139
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
N + + +L TL L H ++S + + L N++ L L+ N +IQ L S L
Sbjct: 140 NNPFVKQKNLITLDLSHNGLSSTKLGTQVQ-LENLQELLLSNN---KIQALKSEELDIFA 195
Query: 217 VSNCELTSLNHNELM-FLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQ 273
S+ + L+ N++ F P H + LF L + + S L
Sbjct: 196 NSSLKKLELSSNQIKEFSPGCFH-------------AIGRLFGLFLNNVQLGPSLTEKLC 242
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANN--TELEYLDLSNNNIASLRYDTFRGLKMLK 331
L S+R L+++ + + F T L LDLS NN+ + D+F L L+
Sbjct: 243 LELAN-TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLE 301
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKD 391
+ L +N I + SL + ++ L L R++ T +S L I
Sbjct: 302 YFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSF------------TKQSISLASLPKIDDF 349
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNL--NYNRISSINNLTFFML--NRL 445
S + L+ + L++ N + I ++ + LKYL+L ++ + ++ N TF L + L
Sbjct: 350 SFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 409
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L++ N+ + I F +LE LDL N
Sbjct: 410 HILNLTKNKISKI-ESDAFSWLGHLEVLDLGLN 441
Score = 64.5 bits (150), Expect = 1e-09
Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 22/283 (7%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-----SLTHLKMSNNYRLELASSANN 255
LL L +SS VS+ E+ +H +L +P ++T L +++N L ++
Sbjct: 14 LLPFGMLCASSTTKCTVSH-EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFT 72
Query: 256 LFSQSLKYIDISYCNI--LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
+SQ L +D+ + I L+P L + P L+ L HN + L FA T L L L
Sbjct: 73 RYSQ-LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLM 131
Query: 313 NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL-----SRV 367
+N+I ++ + F K L LDLS N ++ + +++ +L +L LS N + +
Sbjct: 132 SNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEEL 191
Query: 368 GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL-----DLSQNLLSYIPDSISSNTLK 422
+ S+ L++SS ++ + + L L +L + +++ +++
Sbjct: 192 DIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIR 251
Query: 423 YLNLNYNRISSINNLTFFML--NRLTSLSVVGNRFTMIWRRSF 463
L+L+ +++S+ +N TF L LT L + N ++ SF
Sbjct: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSF 294
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 6/108 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+ +R +P+ L + ++ + N + + P L NL LD+S+N + + D+ L
Sbjct: 469 LQLTRNSFALVPSLQRLMLRRVALKNVDSS--PSPFQPLRNLTILDLSNNNIANINDDML 526
Query: 106 YNLTALEVLNLSRNYFDS-WLNLNPND---VLLPATHLKILDLSFNKF 149
L LE+L+L N W + NP L +HL IL+L N F
Sbjct: 527 EGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGF 574
>BC096333-1|AAH96333.1| 904|Homo sapiens toll-like receptor 3
protein.
Length = 904
Score = 87.4 bits (207), Expect = 2e-16
Identities = 131/501 (26%), Positives = 217/501 (43%), Gaps = 73/501 (14%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQL-KGLPDNALYNLTALEVLNLSRNYFDS 123
KL +S+N+ +F P + L L +++ QL L + L + NLS +
Sbjct: 201 KLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
Query: 124 WLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRS 183
N + L T+L +LDLS+N +GN + L P LE L++ I + S
Sbjct: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWL---PQLEYFFLEYNNIQHLFSHS 317
Query: 184 PLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L GL N+R L L S +S L ++ +L L HL M +
Sbjct: 318 -LHGLFNVRYLNLK------------RSFTKQSISLASLPKIDDFSFQWLKCLEHLNMED 364
Query: 244 NYRLELASSANNLFSQ--SLKYIDIS--YCNILQPNLKGFPSLRKA---ILN--HNMVRY 294
N ++ +N+F+ +LKY+ +S + ++ + F SL + ILN N +
Sbjct: 365 N---DIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISK 421
Query: 295 LESNAFANNTELEYLDLSNNNIAS-LRYDTFRGLKML--------KHLDLSWNEIAVIPE 345
+ES+AF+ LE LDL N I L +RGL+ + K+L L+ N A++P
Sbjct: 422 IESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
Query: 346 DSLLEM-----------PS-------LTQLKLSRNYLSRVGH--LRSMS-VTILDMSSCE 384
L + PS LT L LS N ++ + L + + ILD+
Sbjct: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
Query: 385 LNTIGKDS--------LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSI 434
L + K + L+GL + L+L N IP + + LK ++L N ++++
Sbjct: 542 LARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTL 601
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F L SL++ N T + ++ F + L LD+ N + C C E++ F +
Sbjct: 602 PASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTC--ESIAWFVN 659
Query: 495 FVT-LEPNKKEESFNLICNSP 514
++ N E S + +CN+P
Sbjct: 660 WINETHTNIPELSSHYLCNTP 680
Score = 81.4 bits (192), Expect = 1e-14
Identities = 115/453 (25%), Positives = 194/453 (42%), Gaps = 50/453 (11%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C + DCS LT +P+ L +T LN+++N+ + P + +R L +LD+ N
Sbjct: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ L L L+VLNL N L+ + T+L L L N Q +
Sbjct: 87 ISKLEPELCQKLPMLKVLNLQHNE----LSQLSDKTFAFCTNLTELHLMSNSIQ---KIK 139
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
N + + +L TL L H ++S + + L N++ L L+ N +IQ L S L
Sbjct: 140 NNPFVKQKNLITLDLSHNGLSSTKLGTQVQ-LENLQELLLSNN---KIQALKSEELDIFA 195
Query: 217 VSNCELTSLNHNELM-FLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQ 273
S+ + L+ N++ F P H + LF L + + S L
Sbjct: 196 NSSLKKLELSSNQIKEFSPGCFH-------------AIGRLFGLFLNNVQLGPSLTEKLC 242
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANN--TELEYLDLSNNNIASLRYDTFRGLKMLK 331
L S+R L+++ + + F T L LDLS NN+ + D+F L L+
Sbjct: 243 LELAN-TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLE 301
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKD 391
+ L +N I + SL + ++ L L R++ T +S L I
Sbjct: 302 YFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSF------------TKQSISLASLPKIDDF 349
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNL--NYNRISSINNLTFFML--NRL 445
S + L+ + L++ N + I ++ + LKYL+L ++ + ++ N TF L + L
Sbjct: 350 SFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 409
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L++ N+ + I F +LE LDL N
Sbjct: 410 HILNLTKNKISKI-ESDAFSWLGHLEVLDLGLN 441
Score = 64.5 bits (150), Expect = 1e-09
Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 22/283 (7%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-----SLTHLKMSNNYRLELASSANN 255
LL L +SS VS+ E+ +H +L +P ++T L +++N L ++
Sbjct: 14 LLPFGMLCASSTTKCTVSH-EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFT 72
Query: 256 LFSQSLKYIDISYCNI--LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
+SQ L +D+ + I L+P L + P L+ L HN + L FA T L L L
Sbjct: 73 RYSQ-LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLM 131
Query: 313 NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL-----SRV 367
+N+I ++ + F K L LDLS N ++ + +++ +L +L LS N + +
Sbjct: 132 SNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEEL 191
Query: 368 GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL-----DLSQNLLSYIPDSISSNTLK 422
+ S+ L++SS ++ + + L L +L + +++ +++
Sbjct: 192 DIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIR 251
Query: 423 YLNLNYNRISSINNLTFFML--NRLTSLSVVGNRFTMIWRRSF 463
L+L+ +++S+ +N TF L LT L + N ++ SF
Sbjct: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSF 294
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 6/108 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+ +R +P+ L + ++ + N + + P L NL LD+S+N + + D+ L
Sbjct: 469 LQLTRNSFALVPSLQRLMLRRVALKNVDSS--PSPFQPLRNLTILDLSNNNIANINDDML 526
Query: 106 YNLTALEVLNLSRNYFDS-WLNLNPND---VLLPATHLKILDLSFNKF 149
L LE+L+L N W + NP L +HL IL+L N F
Sbjct: 527 EGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGF 574
>BC059372-1|AAH59372.1| 870|Homo sapiens TLR3 protein protein.
Length = 870
Score = 87.4 bits (207), Expect = 2e-16
Identities = 131/501 (26%), Positives = 217/501 (43%), Gaps = 73/501 (14%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQL-KGLPDNALYNLTALEVLNLSRNYFDS 123
KL +S+N+ +F P + L L +++ QL L + L + NLS +
Sbjct: 201 KLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
Query: 124 WLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRS 183
N + L T+L +LDLS+N +GN + L P LE L++ I + S
Sbjct: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWL---PQLEYFFLEYNNIQHLFSHS 317
Query: 184 PLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L GL N+R L L S +S L ++ +L L HL M +
Sbjct: 318 -LHGLFNVRYLNLK------------RSFTKQSISLASLPKIDDFSFQWLKCLEHLNMED 364
Query: 244 NYRLELASSANNLFSQ--SLKYIDIS--YCNILQPNLKGFPSLRKA---ILN--HNMVRY 294
N ++ +N+F+ +LKY+ +S + ++ + F SL + ILN N +
Sbjct: 365 N---DIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISK 421
Query: 295 LESNAFANNTELEYLDLSNNNIAS-LRYDTFRGLKML--------KHLDLSWNEIAVIPE 345
+ES+AF+ LE LDL N I L +RGL+ + K+L L+ N A++P
Sbjct: 422 IESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
Query: 346 DSLLEM-----------PS-------LTQLKLSRNYLSRVGH--LRSMS-VTILDMSSCE 384
L + PS LT L LS N ++ + L + + ILD+
Sbjct: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
Query: 385 LNTIGKDS--------LEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSI 434
L + K + L+GL + L+L N IP + + LK ++L N ++++
Sbjct: 542 LARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTL 601
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F L SL++ N T + ++ F + L LD+ N + C C E++ F +
Sbjct: 602 PASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTC--ESIAWFVN 659
Query: 495 FVT-LEPNKKEESFNLICNSP 514
++ N E S + +CN+P
Sbjct: 660 WINETHTNIPELSSHYLCNTP 680
Score = 81.4 bits (192), Expect = 1e-14
Identities = 115/453 (25%), Positives = 194/453 (42%), Gaps = 50/453 (11%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C + DCS LT +P+ L +T LN+++N+ + P + +R L +LD+ N
Sbjct: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ L L L+VLNL N L+ + T+L L L N Q +
Sbjct: 87 ISKLEPELCQKLPMLKVLNLQHNE----LSQLSDKTFAFCTNLTELHLMSNSIQ---KIK 139
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
N + + +L TL L H ++S + + L N++ L L+ N +IQ L S L
Sbjct: 140 NNPFVKQKNLITLDLSHNGLSSTKLGTQVQ-LENLQELLLSNN---KIQALKSEELDIFA 195
Query: 217 VSNCELTSLNHNELM-FLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQ 273
S+ + L+ N++ F P H + LF L + + S L
Sbjct: 196 NSSLKKLELSSNQIKEFSPGCFH-------------AIGRLFGLFLNNVQLGPSLTEKLC 242
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANN--TELEYLDLSNNNIASLRYDTFRGLKMLK 331
L S+R L+++ + + F T L LDLS NN+ + D+F L L+
Sbjct: 243 LELAN-TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLE 301
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKD 391
+ L +N I + SL + ++ L L R++ T +S L I
Sbjct: 302 YFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSF------------TKQSISLASLPKIDDF 349
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNL--NYNRISSINNLTFFML--NRL 445
S + L+ + L++ N + I ++ + LKYL+L ++ + ++ N TF L + L
Sbjct: 350 SFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 409
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L++ N+ + I F +LE LDL N
Sbjct: 410 HILNLTKNKISKI-ESDAFSWLGHLEVLDLGLN 441
Score = 64.5 bits (150), Expect = 1e-09
Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 22/283 (7%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-----SLTHLKMSNNYRLELASSANN 255
LL L +SS VS+ E+ +H +L +P ++T L +++N L ++
Sbjct: 14 LLPFGMLCASSTTKCTVSH-EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFT 72
Query: 256 LFSQSLKYIDISYCNI--LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
+SQ L +D+ + I L+P L + P L+ L HN + L FA T L L L
Sbjct: 73 RYSQ-LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLM 131
Query: 313 NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL-----SRV 367
+N+I ++ + F K L LDLS N ++ + +++ +L +L LS N + +
Sbjct: 132 SNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEEL 191
Query: 368 GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL-----DLSQNLLSYIPDSISSNTLK 422
+ S+ L++SS ++ + + L L +L + +++ +++
Sbjct: 192 DIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIR 251
Query: 423 YLNLNYNRISSINNLTFFML--NRLTSLSVVGNRFTMIWRRSF 463
L+L+ +++S+ +N TF L LT L + N ++ SF
Sbjct: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSF 294
Score = 44.8 bits (101), Expect = 0.001
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 6/108 (5%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+ +R +P+ L + ++ + N + + P L NL LD+S+N + + D+ L
Sbjct: 469 LQLTRNSFALVPSLQRLMLRRVALKNVDSS--PSPFQPLRNLTILDLSNNNIANINDDML 526
Query: 106 YNLTALEVLNLSRNYFDS-WLNLNPND---VLLPATHLKILDLSFNKF 149
L LE+L+L N W + NP L +HL IL+L N F
Sbjct: 527 EGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGF 574
>BC034947-1|AAH34947.1| 716|Homo sapiens leucine rich repeat
neuronal 1 protein.
Length = 716
Score = 87.4 bits (207), Expect = 2e-16
Identities = 86/332 (25%), Positives = 156/332 (46%), Gaps = 19/332 (5%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
+ T +DC+ LT IP+ L L + +N K + L +L NL LD S N +
Sbjct: 52 EATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIK 111
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
+ L NLT L L+L N + D+ ++L+ L ++ N+ T+ A L
Sbjct: 112 EVGLANLTQLTTLHLEENQITEMTDYCLQDL----SNLQELYINHNQISTISAHAFAGL- 166
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNL---ISSSLRSLFVS 218
+L L L+ ++ I R N+ +L + NP++ I ++ ++LRSL ++
Sbjct: 167 --KNLLRLHLNSNKLKVIDSRW-FDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLA 223
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPN 275
LT + N L+ L SL L +N +++ A SLK++D++ I + +
Sbjct: 224 GMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKV-PSLKFLDLNKNPIHKIQEGD 282
Query: 276 LKGFPSLRKAILNHNMVRYLESNAFA--NNTELEYLDLSNN-NIASLRYDTFRGLKMLKH 332
K L++ +N NM + + +A N EL L+ +NN ++ + FR + L+
Sbjct: 283 FKNMLRLKELGIN-NMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALES 341
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
L L+ N + I + ++ +P+L ++ + N L
Sbjct: 342 LMLNNNALNAIYQKTVESLPNLREISIHSNPL 373
Score = 71.7 bits (168), Expect = 9e-12
Identities = 76/315 (24%), Positives = 141/315 (44%), Gaps = 14/315 (4%)
Query: 182 RSPLSGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHL 239
R P + + +VL L N + + + + +L L S T++ L L LT L
Sbjct: 65 RIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTL 124
Query: 240 KMSNNYRLELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLES 297
+ N E+ +L + YI+ + + + + G +L + LN N ++ ++S
Sbjct: 125 HLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDS 184
Query: 298 NAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQL 357
F + LE L + N + + F+ L L+ L L+ + IP ++L+ + SL L
Sbjct: 185 RWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESL 244
Query: 358 KLSRNYLSRVGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQ--NLLS-- 410
N L +V L + S+ LD++ ++ I + + + + EL ++ L+S
Sbjct: 245 SFYDNKLVKVPQLALQKVPSLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVD 304
Query: 411 -YIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPY 469
Y D++ T K N ++S I+ L F + L SL + N I++++ +S P
Sbjct: 305 RYALDNLPELT-KLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTV-ESLPN 362
Query: 470 LERLDLSDNMWRCDC 484
L + + N RCDC
Sbjct: 363 LREISIHSNPLRCDC 377
Score = 60.5 bits (140), Expect = 2e-08
Identities = 70/286 (24%), Positives = 125/286 (43%), Gaps = 9/286 (3%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS-NNY-RLELASSANNLFS 258
L RI + +SS + L + + + +EL L +LT L S NN+ ++ AN
Sbjct: 63 LTRIPSNLSSDTQVLLLQSNNIAK-TVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQL 121
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+L + + L+ +L++ +NHN + + ++AFA L L L++N +
Sbjct: 122 TTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKV 181
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTIL 378
+ F L+ L + N + I + + + +L L L+ YL+ + + + L
Sbjct: 182 IDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSL 241
Query: 379 DMSSCELNTIGKD---SLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRIS--- 432
+ S N + K +L+ + S+ LDL++N + I + N L+ L N +
Sbjct: 242 ESLSFYDNKLVKVPQLALQKVPSLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELV 301
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
S++ L LT L N R F S P LE L L++N
Sbjct: 302 SVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNN 347
>AY358312-1|AAQ88679.1| 716|Homo sapiens NLRR protein.
Length = 716
Score = 86.2 bits (204), Expect = 4e-16
Identities = 85/332 (25%), Positives = 156/332 (46%), Gaps = 19/332 (5%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
+ T +DC+ LT IP+ L L + +N K + L +L NL LD S N +
Sbjct: 52 EATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIK 111
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
+ L NLT L L+L N + D+ ++L+ L ++ N+ T+ A L
Sbjct: 112 EVGLANLTQLTTLHLEENQITEMTDYCLQDL----SNLQELYINHNQISTISAHAFAGL- 166
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNL---ISSSLRSLFVS 218
+L L L+ ++ I R N+ +L + NP++ I ++ ++LRSL ++
Sbjct: 167 --KNLLRLHLNSNKLKVIDSRW-FDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLA 223
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPN 275
LT + N L+ L SL L +N +++ A +LK++D++ I + +
Sbjct: 224 GMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKV-PNLKFLDLNKNPIHKIQEGD 282
Query: 276 LKGFPSLRKAILNHNMVRYLESNAFA--NNTELEYLDLSNN-NIASLRYDTFRGLKMLKH 332
K L++ +N NM + + +A N EL L+ +NN ++ + FR + L+
Sbjct: 283 FKNMLRLKELGIN-NMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALES 341
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
L L+ N + I + ++ +P+L ++ + N L
Sbjct: 342 LMLNNNALNAIYQKTVESLPNLREISIHSNPL 373
Score = 70.9 bits (166), Expect = 2e-11
Identities = 76/315 (24%), Positives = 139/315 (44%), Gaps = 14/315 (4%)
Query: 182 RSPLSGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHL 239
R P + + +VL L N + + + + +L L S T++ L L LT L
Sbjct: 65 RIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTL 124
Query: 240 KMSNNYRLELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLES 297
+ N E+ +L + YI+ + + + + G +L + LN N ++ ++S
Sbjct: 125 HLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDS 184
Query: 298 NAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQL 357
F + LE L + N + + F+ L L+ L L+ + IP ++L+ + SL L
Sbjct: 185 RWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESL 244
Query: 358 KLSRNYLSRVGHLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQ--NLLS-- 410
N L +V L V LD++ ++ I + + + + EL ++ L+S
Sbjct: 245 SFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVD 304
Query: 411 -YIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPY 469
Y D++ T K N ++S I+ L F + L SL + N I++++ +S P
Sbjct: 305 RYALDNLPELT-KLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTV-ESLPN 362
Query: 470 LERLDLSDNMWRCDC 484
L + + N RCDC
Sbjct: 363 LREISIHSNPLRCDC 377
Score = 59.7 bits (138), Expect = 4e-08
Identities = 70/286 (24%), Positives = 122/286 (42%), Gaps = 9/286 (3%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS-NNY-RLELASSANNLFS 258
L RI + +SS + L + + + +EL L +LT L S NN+ ++ AN
Sbjct: 63 LTRIPSNLSSDTQVLLLQSNNIAK-TVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQL 121
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+L + + L+ +L++ +NHN + + ++AFA L L L++N +
Sbjct: 122 TTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKV 181
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTIL 378
+ F L+ L + N + I + + + +L L L+ YL+ + + + L
Sbjct: 182 IDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSL 241
Query: 379 DMSSCELNTIGKDSLEGLQSIVE---LDLSQNLLSYIPDSISSNTLKYLNLNYNRIS--- 432
+ S N + K LQ + LDL++N + I + N L+ L N +
Sbjct: 242 ESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELV 301
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
S++ L LT L N R F S P LE L L++N
Sbjct: 302 SVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNN 347
>AF061444-1|AAC77911.1| 907|Homo sapiens G protein-coupled receptor
LGR5 protein.
Length = 907
Score = 86.2 bits (204), Expect = 4e-16
Identities = 109/423 (25%), Positives = 188/423 (44%), Gaps = 37/423 (8%)
Query: 61 GLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
G + +++ S+ ++ P +LS + LD+S N + L N L +L LE L L+ N
Sbjct: 44 GRMLLRVDCSDLGLSELPSNLSVFTSY--LDLSMNNISQLLPNPLPSLHFLEELRLAGNA 101
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
L P LK+L L N+ + + A Q L SL++L LD I+ +
Sbjct: 102 ----LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLR---SLQSLRLDANHISYVP 154
Query: 181 GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLK 240
S SGL ++R L L+ N L I SL +L L ++H +L+
Sbjct: 155 P-SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSWV 213
Query: 241 MSNNYRLELASSANNLFS--QSLKYIDISYCNILQ-PN-LKGFPSLRKAILNHNMVRYLE 296
+ + + + S F SL+ +D++Y N+ + P ++ +L++ + N +R +
Sbjct: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273
Query: 297 SNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQ 356
AF N L + +N I + F+ L L+ L L+ + E P LT
Sbjct: 274 EKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG-------ASQITEFPDLTG 326
Query: 357 LKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI 416
+L S+++T +++++ + L ++ LDLS NLL +P
Sbjct: 327 ----------TANLESLTLT-----GAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFS 371
Query: 417 SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
L+ ++L +N I I TF L L SL++ N+ +I + F + P L +LDLS
Sbjct: 372 VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII-HPNAFSTLPSLIKLDLS 430
Query: 477 DNM 479
N+
Sbjct: 431 SNL 433
Score = 84.6 bits (200), Expect = 1e-15
Identities = 95/346 (27%), Positives = 159/346 (45%), Gaps = 45/346 (13%)
Query: 53 LTDIPNGL--GLQVTK-LNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT IP G GL K L + NN+ P E+L L +L +L + +N + +P + L
Sbjct: 102 LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL 161
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
+L L L D+ L P + L+ + L+ NK + + A +L +
Sbjct: 162 HSLRHLWLD----DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFG------NLSS 211
Query: 169 LILDHCEINSIH--GRSPLSGLINIRVLKLNFNPLLRIQNLI------------SSSLRS 214
++ H N IH G+ GL ++ L LN+N L I S+++RS
Sbjct: 212 WVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRS 271
Query: 215 L----FVSNCELTSLNH--NELMF--------LPSLTHLKMSNNYRL-ELASSANNLFSQ 259
+ FV N L +++ N + F LP L L ++ ++ E +
Sbjct: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLE 331
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ Q P+L+ L++N++ L S F+ +L+ +DL +N I +
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEI 389
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ DTF+ L L+ L+L+WN+IA+I ++ +PSL +L LS N LS
Sbjct: 390 KVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435
Score = 81.4 bits (192), Expect = 1e-14
Identities = 109/407 (26%), Positives = 176/407 (43%), Gaps = 36/407 (8%)
Query: 37 CRCNLDKT---DIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDI 92
C C D +DCS GL+++P+ L + + L++S N ++ P L LH L L +
Sbjct: 38 CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLHFLEELRL 97
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYF-----DSWLNLNPNDVL-LPATHLKILDLS- 145
+ N L +P A L +L+VL L N ++ NL L L A H+ + S
Sbjct: 98 AGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSC 157
Query: 146 FNKFQTMGNL-----ANQELLIRP--SLETLILDHCEINSIHGRSPLS--GLINIRVLKL 196
F+ ++ +L A E+ ++ SL L +N IH + L + VL L
Sbjct: 158 FSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSWVVLHL 217
Query: 197 NFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS----LTHLKMSNNYRLELASS 252
+ N + + L SL E LN+N L P+ L++LK + + S
Sbjct: 218 HNNRIHSLGKKCFDGLHSL-----ETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSI 272
Query: 253 ANNLFSQSLKYIDIS-YCNILQ----PNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
F + I I Y N +Q + P LR LN + E LE
Sbjct: 273 PEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLN-GASQITEFPDLTGTANLE 331
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L+ I+SL L L+ LDLS+N + +P S+ + L+ + Y +V
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKV 391
Query: 368 GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
+ + S+ L+++ ++ I ++ L S+++LDLS NLLS P
Sbjct: 392 DTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP 438
Score = 64.1 bits (149), Expect = 2e-09
Identities = 79/296 (26%), Positives = 132/296 (44%), Gaps = 22/296 (7%)
Query: 67 LNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+ ++ N+ P+ + L + V L + +N++ L L +LE L+L+ N D +
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSWVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF- 249
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
P + ++LK L N +++ A + PSL T+ I + GRS
Sbjct: 250 ---PT-AIRTLSNLKELGFHSNNIRSIPEKA---FVGNPSLITIHFYDNPIQFV-GRSAF 301
Query: 186 SGLINIRVLKLN-FNPLLRIQNLI-SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L +R L LN + + +L +++L SL ++ +++SL LP+L L +S
Sbjct: 302 QHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSY 361
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFP---SLRKAILNHNMVRYLESNAF 300
N +L S + Q L+ ID+ + I + + F SLR L N + + NAF
Sbjct: 362 NLLEDLPSFS---VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 418
Query: 301 ANNTELEYLDLSNNNIASLRYDTFRGLKMLK----HLDLSWNEIAVIPEDSLLEMP 352
+ L LDLS+N ++S GL LK H S PE ++EMP
Sbjct: 419 STLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMP 474
Score = 46.4 bits (105), Expect = 4e-04
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 14/175 (8%)
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
++Q+ PD L LE L L+ S P V +L++LDLS+N + +
Sbjct: 315 ASQITEFPD--LTGTANLESLTLTGAQISSL----PQTVCNQLPNLQVLDLSYNLLEDLP 368
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + + L+ + L H EI I + L+++R L L +N + I S+L
Sbjct: 369 SFS-----VCQKLQKIDLRHNEIYEIKVDT-FQQLLSLRSLNLAWNKIAIIHPNAFSTLP 422
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
SL + L+ + L LTHLK++ N+ L+ S+ N LK I++ Y
Sbjct: 423 SLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENF--PELKVIEMPY 475
Score = 35.5 bits (78), Expect = 0.70
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 1/53 (1%)
Query: 62 LQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEV 113
L + LN++ N+ P + S L +L+ LD+SSN L P L+ LT L++
Sbjct: 398 LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKL 450
>AB074161-1|BAE45733.1| 716|Homo sapiens neuronal leucine-rich
repeat protein-1 protein.
Length = 716
Score = 86.2 bits (204), Expect = 4e-16
Identities = 85/332 (25%), Positives = 156/332 (46%), Gaps = 19/332 (5%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
+ T +DC+ LT IP+ L L + +N K + L +L NL LD S N +
Sbjct: 52 EATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIK 111
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
+ L NLT L L+L N + D+ ++L+ L ++ N+ T+ A L
Sbjct: 112 EVGLANLTQLTTLHLEENQITEMTDYCLQDL----SNLQELYINHNQISTISAHAFAGL- 166
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNL---ISSSLRSLFVS 218
+L L L+ ++ I R N+ +L + NP++ I ++ ++LRSL ++
Sbjct: 167 --KNLLRLHLNSNKLKVIDSRW-FDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLA 223
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPN 275
LT + N L+ L SL L +N +++ A +LK++D++ I + +
Sbjct: 224 GMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKV-PNLKFLDLNKNPIHKIQEGD 282
Query: 276 LKGFPSLRKAILNHNMVRYLESNAFA--NNTELEYLDLSNN-NIASLRYDTFRGLKMLKH 332
K L++ +N NM + + +A N EL L+ +NN ++ + FR + L+
Sbjct: 283 FKNMLRLKELGIN-NMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALES 341
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
L L+ N + I + ++ +P+L ++ + N L
Sbjct: 342 LMLNNNALNAIYQKTVESLPNLREISIHSNPL 373
Score = 70.9 bits (166), Expect = 2e-11
Identities = 76/315 (24%), Positives = 139/315 (44%), Gaps = 14/315 (4%)
Query: 182 RSPLSGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHL 239
R P + + +VL L N + + + + +L L S T++ L L LT L
Sbjct: 65 RIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTL 124
Query: 240 KMSNNYRLELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLES 297
+ N E+ +L + YI+ + + + + G +L + LN N ++ ++S
Sbjct: 125 HLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDS 184
Query: 298 NAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQL 357
F + LE L + N + + F+ L L+ L L+ + IP ++L+ + SL L
Sbjct: 185 RWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESL 244
Query: 358 KLSRNYLSRVGHLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQ--NLLS-- 410
N L +V L V LD++ ++ I + + + + EL ++ L+S
Sbjct: 245 SFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVD 304
Query: 411 -YIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPY 469
Y D++ T K N ++S I+ L F + L SL + N I++++ +S P
Sbjct: 305 RYALDNLPELT-KLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTV-ESLPN 362
Query: 470 LERLDLSDNMWRCDC 484
L + + N RCDC
Sbjct: 363 LREISIHSNPLRCDC 377
Score = 59.7 bits (138), Expect = 4e-08
Identities = 70/286 (24%), Positives = 122/286 (42%), Gaps = 9/286 (3%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS-NNY-RLELASSANNLFS 258
L RI + +SS + L + + + +EL L +LT L S NN+ ++ AN
Sbjct: 63 LTRIPSNLSSDTQVLLLQSNNIAK-TVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQL 121
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+L + + L+ +L++ +NHN + + ++AFA L L L++N +
Sbjct: 122 TTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKV 181
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTIL 378
+ F L+ L + N + I + + + +L L L+ YL+ + + + L
Sbjct: 182 IDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSL 241
Query: 379 DMSSCELNTIGKDSLEGLQSIVE---LDLSQNLLSYIPDSISSNTLKYLNLNYNRIS--- 432
+ S N + K LQ + LDL++N + I + N L+ L N +
Sbjct: 242 ESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELV 301
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
S++ L LT L N R F S P LE L L++N
Sbjct: 302 SVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNN 347
>AB049405-1|BAB39854.1| 928|Homo sapiens VTS20631 protein.
Length = 928
Score = 86.2 bits (204), Expect = 4e-16
Identities = 101/396 (25%), Positives = 172/396 (43%), Gaps = 17/396 (4%)
Query: 47 DCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNAL 105
DCS GL+ +P L L++S N T+ P L L L +S N L +P A
Sbjct: 12 DCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAF 71
Query: 106 YNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPS 165
L +L++L L N L P + L L+ L L N + + + L S
Sbjct: 72 SGLYSLKILMLQNNQ----LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL---SS 124
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFV---SNCEL 222
L L LD + I R+ L+ L ++ + L N + I + +L SL V N +
Sbjct: 125 LRHLWLDDNALTEIPVRA-LNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRI 183
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS-QSLKYIDISYCNILQPNLKGFPS 281
L + L +L L ++ N E + L Q L + + + I + G P
Sbjct: 184 QHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPL 243
Query: 282 LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIA 341
L+ N ++++ +AF +L L L N + + +G L+ L L+ I
Sbjct: 244 LQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGTTSLEILTLTRAGIR 302
Query: 342 VIPEDSLLEMPSLTQLKLSRNYLSRVGHL-RSMSVTILDMSSCELNTIGKDSLEGLQSIV 400
++P ++P L L+LS N + + L R + + + + IG D+ L S+
Sbjct: 303 LLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ 362
Query: 401 ELDLSQNLLSYI-PDSISS-NTLKYLNLNYNRISSI 434
LDLS N + I P++ S+ ++L L+L N+++++
Sbjct: 363 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL 398
Score = 84.2 bits (199), Expect = 2e-15
Identities = 106/384 (27%), Positives = 169/384 (44%), Gaps = 32/384 (8%)
Query: 46 IDCSRRGLTDIPNGLGLQVT---KLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLP 101
+D S LT++ GL + +L +S N + P ++ S L++L L + +NQL G+P
Sbjct: 32 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 91
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
AL+ L +L+ L L N ++L P + L+ L L N + A L
Sbjct: 92 AEALWELPSLQSLRLDANL----ISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL- 146
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE 221
P+L+ + L I+ I + L ++ VL L+ N RIQ+L + S L N E
Sbjct: 147 --PALQAMTLALNRISHIPDYA-FQNLTSLVVLHLHNN---RIQHLGTHSFEGL--HNLE 198
Query: 222 LTSLNHNELMFLP-------SLTHLKMSNNYRLELASSA--NNLFSQSLKYIDISYCNIL 272
LN+N+L P L L NN + A N Q++ + D +
Sbjct: 199 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 258
Query: 273 QPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
+ + P L LN M E T LE L L+ I L + L L+
Sbjct: 259 RSAFQYLPKLHTLSLNGAM-DIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRV 317
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIG 389
L+LS N+I +P SL L ++ L N + +G + S+ LD+S + +I
Sbjct: 318 LELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIH 375
Query: 390 KDSLEGLQSIVELDLSQNLLSYIP 413
++ L S+V+LDL+ N L+ +P
Sbjct: 376 PEAFSTLHSLVKLDLTDNQLTTLP 399
Score = 72.1 bits (169), Expect = 7e-12
Identities = 65/251 (25%), Positives = 110/251 (43%), Gaps = 5/251 (1%)
Query: 233 LPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMV 292
L + L M+N L+ + F + L+ +I G SL+ +L +N +
Sbjct: 28 LTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 87
Query: 293 RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP 352
+ + A L+ L L N I+ + +F GL L+HL L N + IP +L +P
Sbjct: 88 GGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP 147
Query: 353 SLTQLKLSRNYLSRVGHLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLL 409
+L + L+ N +S + ++T +L + + + +G S EGL ++ LDL+ N L
Sbjct: 148 ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 207
Query: 410 SYIPDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNP 468
P +I + L+ L + N I +I F L ++ N + RS F P
Sbjct: 208 QEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFV-GRSAFQYLP 266
Query: 469 YLERLDLSDNM 479
L L L+ M
Sbjct: 267 KLHTLSLNGAM 277
Score = 65.7 bits (153), Expect = 6e-10
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 17/298 (5%)
Query: 69 ISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL 127
+ +N T+ P +L+ L L + ++ N++ +PD A NLT+L VL+L N L
Sbjct: 130 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH-LGT 188
Query: 128 NPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSG 187
+ + L +L+ LDL++NK Q +A + L L+ L + I +I ++ +
Sbjct: 189 HSFEGL---HNLETLDLNYNKLQEFP-VAIRTL---GRLQELGFHNNNIKAIPEKAFMGN 241
Query: 188 LINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
+ ++ + NP+ + L L + +++ E L T L++ R
Sbjct: 242 PL-LQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRA 299
Query: 248 ELASSANNLFSQ--SLKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNT 304
+ + + Q L+ +++S+ I + P+L L + L HN + + ++ F+ +
Sbjct: 300 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLS 359
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
L+ LDLS N I S+ + F L L LDL+ N++ +P L + L LKL N
Sbjct: 360 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 414
Score = 60.9 bits (141), Expect = 2e-08
Identities = 68/271 (25%), Positives = 116/271 (42%), Gaps = 12/271 (4%)
Query: 194 LKLNFNPLLRIQNLISS---SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELA 250
L+L+ N L I S SL+ L + N +L + L LPSL L++ N + L
Sbjct: 56 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANL-ISLV 114
Query: 251 SSANNLFSQSLKYI---DISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
+ SL+++ D + I L P+L+ L N + ++ AF N T L
Sbjct: 115 PERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLV 174
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L NN I L +F GL L+ LDL++N++ P ++ + L +L N + +
Sbjct: 175 VLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAI 233
Query: 368 GHLRSMSVTILD---MSSCELNTIGKDSLEGLQSIVELDLSQNL-LSYIPDSISSNTLKY 423
M +L + +G+ + + L + L L+ + + PD + +L+
Sbjct: 234 PEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEI 293
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNR 454
L L I + + L RL L + N+
Sbjct: 294 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 324
Score = 49.6 bits (113), Expect = 4e-05
Identities = 52/188 (27%), Positives = 89/188 (47%), Gaps = 16/188 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
L +LH L +L+ + ++ PD L T+LE+L L+R + + L P+ + L+
Sbjct: 265 LPKLHTL-SLN-GAMDIQEFPD--LKGTTSLEILTLTR----AGIRLLPSGMCQQLPRLR 316
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
+L+LS N+ + + +L + LE + L H I I G S L +++ L L++N
Sbjct: 317 VLELSHNQIEELPSLHRCQ-----KLEEIGLQHNRIWEI-GADTFSQLSSLQALDLSWNA 370
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
+ I S+L SL + L L L L HLK+ N L A S ++
Sbjct: 371 IRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF--PK 428
Query: 261 LKYIDISY 268
L+ +++ Y
Sbjct: 429 LRILEVPY 436
>AB040930-1|BAA96021.1| 730|Homo sapiens KIAA1497 protein protein.
Length = 730
Score = 86.2 bits (204), Expect = 4e-16
Identities = 85/332 (25%), Positives = 156/332 (46%), Gaps = 19/332 (5%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
+ T +DC+ LT IP+ L L + +N K + L +L NL LD S N +
Sbjct: 66 EATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIK 125
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
+ L NLT L L+L N + D+ ++L+ L ++ N+ T+ A L
Sbjct: 126 EVGLANLTQLTTLHLEENQITEMTDYCLQDL----SNLQELYINHNQISTISAHAFAGL- 180
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNL---ISSSLRSLFVS 218
+L L L+ ++ I R N+ +L + NP++ I ++ ++LRSL ++
Sbjct: 181 --KNLLRLHLNSNKLKVIDSRW-FDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLA 237
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPN 275
LT + N L+ L SL L +N +++ A +LK++D++ I + +
Sbjct: 238 GMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKV-PNLKFLDLNKNPIHKIQEGD 296
Query: 276 LKGFPSLRKAILNHNMVRYLESNAFA--NNTELEYLDLSNN-NIASLRYDTFRGLKMLKH 332
K L++ +N NM + + +A N EL L+ +NN ++ + FR + L+
Sbjct: 297 FKNMLRLKELGIN-NMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALES 355
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
L L+ N + I + ++ +P+L ++ + N L
Sbjct: 356 LMLNNNALNAIYQKTVESLPNLREISIHSNPL 387
Score = 70.9 bits (166), Expect = 2e-11
Identities = 76/315 (24%), Positives = 139/315 (44%), Gaps = 14/315 (4%)
Query: 182 RSPLSGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHL 239
R P + + +VL L N + + + + +L L S T++ L L LT L
Sbjct: 79 RIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTL 138
Query: 240 KMSNNYRLELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLES 297
+ N E+ +L + YI+ + + + + G +L + LN N ++ ++S
Sbjct: 139 HLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDS 198
Query: 298 NAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQL 357
F + LE L + N + + F+ L L+ L L+ + IP ++L+ + SL L
Sbjct: 199 RWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESL 258
Query: 358 KLSRNYLSRVGHLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQ--NLLS-- 410
N L +V L V LD++ ++ I + + + + EL ++ L+S
Sbjct: 259 SFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVD 318
Query: 411 -YIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPY 469
Y D++ T K N ++S I+ L F + L SL + N I++++ +S P
Sbjct: 319 RYALDNLPELT-KLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTV-ESLPN 376
Query: 470 LERLDLSDNMWRCDC 484
L + + N RCDC
Sbjct: 377 LREISIHSNPLRCDC 391
Score = 59.7 bits (138), Expect = 4e-08
Identities = 70/286 (24%), Positives = 122/286 (42%), Gaps = 9/286 (3%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS-NNY-RLELASSANNLFS 258
L RI + +SS + L + + + +EL L +LT L S NN+ ++ AN
Sbjct: 77 LTRIPSNLSSDTQVLLLQSNNIAK-TVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQL 135
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+L + + L+ +L++ +NHN + + ++AFA L L L++N +
Sbjct: 136 TTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKV 195
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTIL 378
+ F L+ L + N + I + + + +L L L+ YL+ + + + L
Sbjct: 196 IDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSL 255
Query: 379 DMSSCELNTIGKDSLEGLQSIVE---LDLSQNLLSYIPDSISSNTLKYLNLNYNRIS--- 432
+ S N + K LQ + LDL++N + I + N L+ L N +
Sbjct: 256 ESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELV 315
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
S++ L LT L N R F S P LE L L++N
Sbjct: 316 SVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNN 361
>BC047905-1|AAH47905.2| 915|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 6 protein.
Length = 915
Score = 85.8 bits (203), Expect = 5e-16
Identities = 108/397 (27%), Positives = 175/397 (44%), Gaps = 32/397 (8%)
Query: 33 LCFLCRCNLDKTDIDCSRRGLTDIPNGLGLQVT---KLNISNNEFTKFP-ESLSRLHNLV 88
L +C+ ++ + D S LT++ GL + +L +S N + P ++ S L++L
Sbjct: 6 LTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLK 65
Query: 89 NLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNK 148
L + +NQL G+P AL+ L +L+ L L N ++L P + L+ L L N
Sbjct: 66 ILMLQNNQLGGIPAEALWELPSLQSLRLDANL----ISLVPERSFEGLSSLRHLWLDDNA 121
Query: 149 FQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLI 208
+ A L P+L+ + L I+ I + L ++ VL L+ N RIQ+L
Sbjct: 122 LTEIPVRALNNL---PALQAMTLALNRISHIPDYA-FQNLTSLVVLHLHNN---RIQHLG 174
Query: 209 SSSLRSLFVSNCELTSLNHNELMFLP-------SLTHLKMSNNYRLELASSA--NNLFSQ 259
+ S L N E LN+N+L P L L NN + A N Q
Sbjct: 175 THSFEGL--HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQ 232
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
++ + D + + + P L LN M E T LE L L+ I L
Sbjct: 233 TIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAM-DIQEFPDLKGTTSLEILTLTRAGIRLL 291
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVT 376
+ L L+ L+LS N+I +P SL L ++ L N + +G + S+
Sbjct: 292 PSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ 349
Query: 377 ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
LD+S + +I ++ L S+V+LDL+ N L+ +P
Sbjct: 350 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 386
Score = 72.5 bits (170), Expect = 5e-12
Identities = 65/255 (25%), Positives = 112/255 (43%), Gaps = 5/255 (1%)
Query: 229 ELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN 288
++ + S L M+N L+ + F + L+ +I G SL+ +L
Sbjct: 11 QVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQ 70
Query: 289 HNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
+N + + + A L+ L L N I+ + +F GL L+HL L N + IP +L
Sbjct: 71 NNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRAL 130
Query: 349 LEMPSLTQLKLSRNYLSRVGHLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+P+L + L+ N +S + ++T +L + + + +G S EGL ++ LDL+
Sbjct: 131 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLN 190
Query: 406 QNLLSYIPDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFF 464
N L P +I + L+ L + N I +I F L ++ N + RS F
Sbjct: 191 YNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFV-GRSAF 249
Query: 465 DSNPYLERLDLSDNM 479
P L L L+ M
Sbjct: 250 QYLPKLHTLSLNGAM 264
Score = 65.7 bits (153), Expect = 6e-10
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 17/298 (5%)
Query: 69 ISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL 127
+ +N T+ P +L+ L L + ++ N++ +PD A NLT+L VL+L N L
Sbjct: 117 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH-LGT 175
Query: 128 NPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSG 187
+ + L +L+ LDL++NK Q +A + L L+ L + I +I ++ +
Sbjct: 176 HSFEGL---HNLETLDLNYNKLQEFP-VAIRTL---GRLQELGFHNNNIKAIPEKAFMGN 228
Query: 188 LINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
+ ++ + NP+ + L L + +++ E L T L++ R
Sbjct: 229 PL-LQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRA 286
Query: 248 ELASSANNLFSQ--SLKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNT 304
+ + + Q L+ +++S+ I + P+L L + L HN + + ++ F+ +
Sbjct: 287 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLS 346
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
L+ LDLS N I S+ + F L L LDL+ N++ +P L + L LKL N
Sbjct: 347 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
Score = 49.6 bits (113), Expect = 4e-05
Identities = 52/188 (27%), Positives = 89/188 (47%), Gaps = 16/188 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
L +LH L +L+ + ++ PD L T+LE+L L+R + + L P+ + L+
Sbjct: 252 LPKLHTL-SLN-GAMDIQEFPD--LKGTTSLEILTLTR----AGIRLLPSGMCQQLPRLR 303
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
+L+LS N+ + + +L + LE + L H I I G S L +++ L L++N
Sbjct: 304 VLELSHNQIEELPSLHRCQ-----KLEEIGLQHNRIWEI-GADTFSQLSSLQALDLSWNA 357
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
+ I S+L SL + L L L L HLK+ N L A S ++
Sbjct: 358 IRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF--PK 415
Query: 261 LKYIDISY 268
L+ +++ Y
Sbjct: 416 LRILEVPY 423
>AY358119-1|AAQ88486.1| 915|Homo sapiens gonadotropin receptor
protein.
Length = 915
Score = 85.8 bits (203), Expect = 5e-16
Identities = 108/397 (27%), Positives = 175/397 (44%), Gaps = 32/397 (8%)
Query: 33 LCFLCRCNLDKTDIDCSRRGLTDIPNGLGLQVT---KLNISNNEFTKFP-ESLSRLHNLV 88
L +C+ ++ + D S LT++ GL + +L +S N + P ++ S L++L
Sbjct: 6 LTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLK 65
Query: 89 NLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNK 148
L + +NQL G+P AL+ L +L+ L L N ++L P + L+ L L N
Sbjct: 66 ILMLQNNQLGGIPAEALWELPSLQSLRLDANL----ISLVPERSFEGLSSLRHLWLDDNA 121
Query: 149 FQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLI 208
+ A L P+L+ + L I+ I + L ++ VL L+ N RIQ+L
Sbjct: 122 LTEIPVRALNNL---PALQAMTLALNRISHIPDYA-FQNLTSLVVLHLHNN---RIQHLG 174
Query: 209 SSSLRSLFVSNCELTSLNHNELMFLP-------SLTHLKMSNNYRLELASSA--NNLFSQ 259
+ S L N E LN+N+L P L L NN + A N Q
Sbjct: 175 THSFEGL--HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQ 232
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
++ + D + + + P L LN M E T LE L L+ I L
Sbjct: 233 TIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAM-DIQEFPDLKGTTSLEILTLTRAGIRLL 291
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVT 376
+ L L+ L+LS N+I +P SL L ++ L N + +G + S+
Sbjct: 292 PSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ 349
Query: 377 ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
LD+S + +I ++ L S+V+LDL+ N L+ +P
Sbjct: 350 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 386
Score = 72.5 bits (170), Expect = 5e-12
Identities = 65/255 (25%), Positives = 112/255 (43%), Gaps = 5/255 (1%)
Query: 229 ELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN 288
++ + S L M+N L+ + F + L+ +I G SL+ +L
Sbjct: 11 QVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQ 70
Query: 289 HNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
+N + + + A L+ L L N I+ + +F GL L+HL L N + IP +L
Sbjct: 71 NNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRAL 130
Query: 349 LEMPSLTQLKLSRNYLSRVGHLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+P+L + L+ N +S + ++T +L + + + +G S EGL ++ LDL+
Sbjct: 131 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLN 190
Query: 406 QNLLSYIPDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFF 464
N L P +I + L+ L + N I +I F L ++ N + RS F
Sbjct: 191 YNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFV-GRSAF 249
Query: 465 DSNPYLERLDLSDNM 479
P L L L+ M
Sbjct: 250 QYLPKLHTLSLNGAM 264
Score = 65.7 bits (153), Expect = 6e-10
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 17/298 (5%)
Query: 69 ISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL 127
+ +N T+ P +L+ L L + ++ N++ +PD A NLT+L VL+L N L
Sbjct: 117 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH-LGT 175
Query: 128 NPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSG 187
+ + L +L+ LDL++NK Q +A + L L+ L + I +I ++ +
Sbjct: 176 HSFEGL---HNLETLDLNYNKLQEFP-VAIRTL---GRLQELGFHNNNIKAIPEKAFMGN 228
Query: 188 LINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
+ ++ + NP+ + L L + +++ E L T L++ R
Sbjct: 229 PL-LQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRA 286
Query: 248 ELASSANNLFSQ--SLKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNT 304
+ + + Q L+ +++S+ I + P+L L + L HN + + ++ F+ +
Sbjct: 287 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLS 346
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
L+ LDLS N I S+ + F L L LDL+ N++ +P L + L LKL N
Sbjct: 347 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
Score = 49.6 bits (113), Expect = 4e-05
Identities = 52/188 (27%), Positives = 89/188 (47%), Gaps = 16/188 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
L +LH L +L+ + ++ PD L T+LE+L L+R + + L P+ + L+
Sbjct: 252 LPKLHTL-SLN-GAMDIQEFPD--LKGTTSLEILTLTR----AGIRLLPSGMCQQLPRLR 303
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
+L+LS N+ + + +L + LE + L H I I G S L +++ L L++N
Sbjct: 304 VLELSHNQIEELPSLHRCQ-----KLEEIGLQHNRIWEI-GADTFSQLSSLQALDLSWNA 357
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
+ I S+L SL + L L L L HLK+ N L A S ++
Sbjct: 358 IRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF--PK 415
Query: 261 LKYIDISY 268
L+ +++ Y
Sbjct: 416 LRILEVPY 423
>AL356953-3|CAI15929.1| 915|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 6 protein.
Length = 915
Score = 85.8 bits (203), Expect = 5e-16
Identities = 108/397 (27%), Positives = 175/397 (44%), Gaps = 32/397 (8%)
Query: 33 LCFLCRCNLDKTDIDCSRRGLTDIPNGLGLQVT---KLNISNNEFTKFP-ESLSRLHNLV 88
L +C+ ++ + D S LT++ GL + +L +S N + P ++ S L++L
Sbjct: 6 LTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLK 65
Query: 89 NLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNK 148
L + +NQL G+P AL+ L +L+ L L N ++L P + L+ L L N
Sbjct: 66 ILMLQNNQLGGIPAEALWELPSLQSLRLDANL----ISLVPERSFEGLSSLRHLWLDDNA 121
Query: 149 FQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLI 208
+ A L P+L+ + L I+ I + L ++ VL L+ N RIQ+L
Sbjct: 122 LTEIPVRALNNL---PALQAMTLALNRISHIPDYA-FQNLTSLVVLHLHNN---RIQHLG 174
Query: 209 SSSLRSLFVSNCELTSLNHNELMFLP-------SLTHLKMSNNYRLELASSA--NNLFSQ 259
+ S L N E LN+N+L P L L NN + A N Q
Sbjct: 175 THSFEGL--HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQ 232
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
++ + D + + + P L LN M E T LE L L+ I L
Sbjct: 233 TIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAM-DIQEFPDLKGTTSLEILTLTRAGIRLL 291
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVT 376
+ L L+ L+LS N+I +P SL L ++ L N + +G + S+
Sbjct: 292 PSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ 349
Query: 377 ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
LD+S + +I ++ L S+V+LDL+ N L+ +P
Sbjct: 350 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 386
Score = 72.5 bits (170), Expect = 5e-12
Identities = 65/255 (25%), Positives = 112/255 (43%), Gaps = 5/255 (1%)
Query: 229 ELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN 288
++ + S L M+N L+ + F + L+ +I G SL+ +L
Sbjct: 11 QVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQ 70
Query: 289 HNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
+N + + + A L+ L L N I+ + +F GL L+HL L N + IP +L
Sbjct: 71 NNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRAL 130
Query: 349 LEMPSLTQLKLSRNYLSRVGHLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+P+L + L+ N +S + ++T +L + + + +G S EGL ++ LDL+
Sbjct: 131 NNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLN 190
Query: 406 QNLLSYIPDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFF 464
N L P +I + L+ L + N I +I F L ++ N + RS F
Sbjct: 191 YNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFV-GRSAF 249
Query: 465 DSNPYLERLDLSDNM 479
P L L L+ M
Sbjct: 250 QYLPKLHTLSLNGAM 264
Score = 65.7 bits (153), Expect = 6e-10
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 17/298 (5%)
Query: 69 ISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL 127
+ +N T+ P +L+ L L + ++ N++ +PD A NLT+L VL+L N L
Sbjct: 117 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH-LGT 175
Query: 128 NPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSG 187
+ + L +L+ LDL++NK Q +A + L L+ L + I +I ++ +
Sbjct: 176 HSFEGL---HNLETLDLNYNKLQEFP-VAIRTL---GRLQELGFHNNNIKAIPEKAFMGN 228
Query: 188 LINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
+ ++ + NP+ + L L + +++ E L T L++ R
Sbjct: 229 PL-LQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRA 286
Query: 248 ELASSANNLFSQ--SLKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNT 304
+ + + Q L+ +++S+ I + P+L L + L HN + + ++ F+ +
Sbjct: 287 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLS 346
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
L+ LDLS N I S+ + F L L LDL+ N++ +P L + L LKL N
Sbjct: 347 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
Score = 49.6 bits (113), Expect = 4e-05
Identities = 52/188 (27%), Positives = 89/188 (47%), Gaps = 16/188 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
L +LH L +L+ + ++ PD L T+LE+L L+R + + L P+ + L+
Sbjct: 252 LPKLHTL-SLN-GAMDIQEFPD--LKGTTSLEILTLTR----AGIRLLPSGMCQQLPRLR 303
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
+L+LS N+ + + +L + LE + L H I I G S L +++ L L++N
Sbjct: 304 VLELSHNQIEELPSLHRCQ-----KLEEIGLQHNRIWEI-GADTFSQLSSLQALDLSWNA 357
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
+ I S+L SL + L L L L HLK+ N L A S ++
Sbjct: 358 IRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF--PK 415
Query: 261 LKYIDISY 268
L+ +++ Y
Sbjct: 416 LRILEVPY 423
>J05158-1|AAA51921.2| 545|Homo sapiens carboxypeptidase N precursor
protein.
Length = 545
Score = 83.4 bits (197), Expect = 3e-15
Identities = 88/309 (28%), Positives = 134/309 (43%), Gaps = 35/309 (11%)
Query: 186 SGLINIRVLKLNFNPLLRI-QNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
S L ++ L LNFN L + + L ++L SL + +L +L +F P LTHLK
Sbjct: 118 SNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRR--LFQP-LTHLKTL 174
Query: 243 NNYRLELASSANNLFS-----QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLES 297
N + LA LF Q+LK + + + Q SL++ L+ N + L
Sbjct: 175 NLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPP 234
Query: 298 NAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQL 357
F+ LE L L N I L F L L L L WN + V+P P L L
Sbjct: 235 QVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGL 294
Query: 358 KLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSIS 417
L+ N +L T+ + + L ++ L LS N ++++P I
Sbjct: 295 SLTHN---------------------QLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIF 333
Query: 418 SNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDL 475
+ L L L N +++++ F L++L LS+ N+ T + FD+N L L L
Sbjct: 334 RDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL-PEGIFDTNYNLFNLAL 392
Query: 476 SDNMWRCDC 484
N W+CDC
Sbjct: 393 HGNPWQCDC 401
Score = 70.5 bits (165), Expect = 2e-11
Identities = 61/212 (28%), Positives = 96/212 (45%), Gaps = 9/212 (4%)
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+ L+ S+ N+ SL K LN NM+ L F + LE L L N + +
Sbjct: 100 EDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQA 159
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-----GHLRSM 373
L F+ L LK L+L+ N +A +PE+ + SL LKLS N LS + G L S+
Sbjct: 160 LPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSL 219
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
LD S ++ + L + L L +N ++++P SI S L +L+L +N +
Sbjct: 220 QELFLD--SNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNML 277
Query: 432 SSINNLTFFMLNRLTSLSVVGNRFTMIWRRSF 463
+ F L LS+ N+ + +F
Sbjct: 278 RVLPAGLFAHTPCLVGLSLTHNQLETVAEGTF 309
Score = 68.1 bits (159), Expect = 1e-10
Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 17/378 (4%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL 97
C+ ++ CS L +P + + FT + NL + + QL
Sbjct: 26 CDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQL 85
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLAN 157
+A L LE L ++ + S+LNL+ N + T L L L+FN + +
Sbjct: 86 CQFRPDAFGGLPRLEDLEVTGS---SFLNLSTN-IFSNLTSLGKLTLNFNMLEALPEGLF 141
Query: 158 QELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS---SSLRS 214
Q L +LE+L L ++ ++ R L +++ L L N L ++ + +SL++
Sbjct: 142 QHLA---ALESLHLQGNQLQALPRRL-FQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQT 197
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCNILQ 273
L +SN L+ L L SL L + +N EL + LF ++ + L
Sbjct: 198 LKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLP 257
Query: 274 PNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
++ +L L NM+R L + FA+ L L L++N + ++ TF L L+
Sbjct: 258 LSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRS 317
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIG 389
L LS+N I +P ++ L +L L N L+ + +++S + +L +S +L T+
Sbjct: 318 LMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLP 377
Query: 390 KDSLEGLQSIVELDLSQN 407
+ + ++ L L N
Sbjct: 378 EGIFDTNYNLFNLALHGN 395
>BC050445-1|AAH50445.1| 582|Homo sapiens soc-2 suppressor of clear
homolog (C. elegans) protein.
Length = 582
Score = 83.4 bits (197), Expect = 3e-15
Identities = 116/448 (25%), Positives = 208/448 (46%), Gaps = 40/448 (8%)
Query: 46 IDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
+D S+R + +P+ + Q+T+L + +N+ P + L NL+ L +S N L LPD
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD- 163
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIR 163
+L NL L +L+L N L P+ V+ L L L FN+ T+ +++
Sbjct: 164 SLDNLKKLRMLDLRHNK----LREIPS-VVYRLDSLTTLYLRFNRITTV----EKDIKNL 214
Query: 164 PSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELT 223
L L + +I + + + L N+ L + N L + I + + ++N +
Sbjct: 215 SKLSMLSIRENKIKQL--PAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ---ITNLD-- 267
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSL-KYIDISYCNILQPNLKGFP-S 281
L HNEL+ LP T +S+ RL L + + +SL K + N+ N+ P S
Sbjct: 268 -LQHNELLDLPD-TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPES 325
Query: 282 LRKAILNHNMVRYLESNAF--------ANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L +++ N + L N F + + + L++ +N I + + F K+L L
Sbjct: 326 LLSSLVKLNSLT-LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKL 384
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMSSCELNTIGKD 391
++ N++ +P D S+ +L L+ N L+++ S +S+ +L +S+ L +
Sbjct: 385 NMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL-PH 442
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L L+ + ELDL +N L +P+ I+ L+ L L N+++++ + N LT L +
Sbjct: 443 GLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN-LTHLGL 501
Query: 451 VGNRFTMIWRRSFFDSNPYLERLDLSDN 478
N T + N LE L L+DN
Sbjct: 502 GENLLTHLPEEIGTLEN--LEELYLNDN 527
Score = 75.8 bits (178), Expect = 5e-13
Identities = 102/419 (24%), Positives = 184/419 (43%), Gaps = 22/419 (5%)
Query: 66 KLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+L++S P S+ L L L + SN+L+ LP + L L L LS N S
Sbjct: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE-VGCLVNLMTLALSENSLTSL- 161
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
D L L++LDL NK + + ++ + SL TL L I ++ +
Sbjct: 162 ----PDSLDNLKKLRMLDLRHNKLREIPSVVYR----LDSLTTLYLRFNRITTV--EKDI 211
Query: 186 SGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L + +L + N + ++ I +L +L V++ +L L E+ +T+L + +
Sbjct: 212 KNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQH 270
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANN 303
N L+L + NL S S + + + + +L +L + L +N + L + ++
Sbjct: 271 NELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY 363
+L L L+ N + L++ N I IP L++L + N
Sbjct: 331 VKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQ 390
Query: 364 LSR--VGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NT 420
L+ + S+ L++++ +L I +D + GL S+ L LS NLL +P + +
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPED-VSGLVSLEVLILSNNLLKKLPHGLGNLRK 449
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
L+ L+L N++ S+ N + L L L + N+ T + R +N L L L +N+
Sbjct: 450 LRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN--LTHLGLGENL 505
Score = 59.3 bits (137), Expect = 5e-08
Identities = 65/267 (24%), Positives = 120/267 (44%), Gaps = 23/267 (8%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T++D L D+P+ +G +++L + N + P SL++ L L++ +N + LP
Sbjct: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLP 323
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPND----VLLPATHLKILDLSFNKFQ-----TM 152
++ L +L L L L+RN F + P+ L H +I + F F +
Sbjct: 324 ESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSK 383
Query: 153 GNLANQELLIRP-------SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
N+ + +L P S+ L L ++ I +SGL+++ VL L+ N L ++
Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKI--PEDVSGLVSLEVLILSNNLLKKLP 441
Query: 206 NLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
+ + + LR L + +L SL NE+ +L L L ++NN L +L + +
Sbjct: 442 HGLGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLG 500
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHN 290
+ + L + +L + LN N
Sbjct: 501 LGENLLTHLPEEIGTLENLEELYLNDN 527
Score = 55.6 bits (128), Expect = 6e-07
Identities = 64/205 (31%), Positives = 94/205 (45%), Gaps = 27/205 (13%)
Query: 53 LTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTA 110
LT +P G + +LN++ N+ TK PE +S L +L L +S+N LK LP + L NL
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP-HGLGNLRK 449
Query: 111 LEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM----GNLANQELLIRPSL 166
L L+L N +S PN++ L+ L L+ N+ T+ G+L N L L
Sbjct: 450 LRELDLEENKLESL----PNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN---LTHLGL 501
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLR---IQNLISSSLRSLFVSNCELT 223
+L H + L N+ L LN NP L + + S L + + NC L+
Sbjct: 502 GENLLTHLP-------EEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Query: 224 SLNHNELMFLPS--LTHLKMSNNYR 246
L + PS + LKM YR
Sbjct: 555 HLPPQIVAGGPSFIIQFLKMQGPYR 579
>BC031569-1|AAH31569.2| 545|Homo sapiens carboxypeptidase N,
polypeptide 2 protein.
Length = 545
Score = 83.4 bits (197), Expect = 3e-15
Identities = 88/309 (28%), Positives = 134/309 (43%), Gaps = 35/309 (11%)
Query: 186 SGLINIRVLKLNFNPLLRI-QNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
S L ++ L LNFN L + + L ++L SL + +L +L +F P LTHLK
Sbjct: 118 SNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRR--LFQP-LTHLKTL 174
Query: 243 NNYRLELASSANNLFS-----QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLES 297
N + LA LF Q+LK + + + Q SL++ L+ N + L
Sbjct: 175 NLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPP 234
Query: 298 NAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQL 357
F+ LE L L N I L F L L L L WN + V+P P L L
Sbjct: 235 QVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGL 294
Query: 358 KLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSIS 417
L+ N +L T+ + + L ++ L LS N ++++P I
Sbjct: 295 SLTHN---------------------QLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIF 333
Query: 418 SNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDL 475
+ L L L N +++++ F L++L LS+ N+ T + FD+N L L L
Sbjct: 334 RDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL-PEGIFDTNYNLFNLAL 392
Query: 476 SDNMWRCDC 484
N W+CDC
Sbjct: 393 HGNPWQCDC 401
Score = 70.5 bits (165), Expect = 2e-11
Identities = 61/212 (28%), Positives = 96/212 (45%), Gaps = 9/212 (4%)
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+ L+ S+ N+ SL K LN NM+ L F + LE L L N + +
Sbjct: 100 EDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQA 159
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-----GHLRSM 373
L F+ L LK L+L+ N +A +PE+ + SL LKLS N LS + G L S+
Sbjct: 160 LPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSL 219
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
LD S ++ + L + L L +N ++++P SI S L +L+L +N +
Sbjct: 220 QELFLD--SNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNML 277
Query: 432 SSINNLTFFMLNRLTSLSVVGNRFTMIWRRSF 463
+ F L LS+ N+ + +F
Sbjct: 278 RVLPAGLFAHTPCLVGLSLTHNQLETVAEGTF 309
Score = 68.1 bits (159), Expect = 1e-10
Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 17/378 (4%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL 97
C+ ++ CS L +P + + FT + NL + + QL
Sbjct: 26 CDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQL 85
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLAN 157
+A L LE L ++ + S+LNL+ N + T L L L+FN + +
Sbjct: 86 CQFRPDAFGGLPRLEDLEVTGS---SFLNLSTN-IFSNLTSLGKLTLNFNMLEALPEGLF 141
Query: 158 QELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS---SSLRS 214
Q L +LE+L L ++ ++ R L +++ L L N L ++ + +SL++
Sbjct: 142 QHLA---ALESLHLQGNQLQALPRRL-FQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQT 197
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCNILQ 273
L +SN L+ L L SL L + +N EL + LF ++ + L
Sbjct: 198 LKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLP 257
Query: 274 PNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
++ +L L NM+R L + FA+ L L L++N + ++ TF L L+
Sbjct: 258 LSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRS 317
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIG 389
L LS+N I +P ++ L +L L N L+ + +++S + +L +S +L T+
Sbjct: 318 LMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLP 377
Query: 390 KDSLEGLQSIVELDLSQN 407
+ + ++ L L N
Sbjct: 378 EGIFDTNYNLFNLALHGN 395
>AL158163-2|CAH72812.1| 582|Homo sapiens soc-2 suppressor of clear
homolog (C. elegans) protein.
Length = 582
Score = 83.4 bits (197), Expect = 3e-15
Identities = 116/448 (25%), Positives = 208/448 (46%), Gaps = 40/448 (8%)
Query: 46 IDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
+D S+R + +P+ + Q+T+L + +N+ P + L NL+ L +S N L LPD
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD- 163
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIR 163
+L NL L +L+L N L P+ V+ L L L FN+ T+ +++
Sbjct: 164 SLDNLKKLRMLDLRHNK----LREIPS-VVYRLDSLTTLYLRFNRITTV----EKDIKNL 214
Query: 164 PSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELT 223
L L + +I + + + L N+ L + N L + I + + ++N +
Sbjct: 215 SKLSMLSIRENKIKQL--PAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ---ITNLD-- 267
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSL-KYIDISYCNILQPNLKGFP-S 281
L HNEL+ LP T +S+ RL L + + +SL K + N+ N+ P S
Sbjct: 268 -LQHNELLDLPD-TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPES 325
Query: 282 LRKAILNHNMVRYLESNAF--------ANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L +++ N + L N F + + + L++ +N I + + F K+L L
Sbjct: 326 LLSSLVKLNSLT-LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKL 384
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMSSCELNTIGKD 391
++ N++ +P D S+ +L L+ N L+++ S +S+ +L +S+ L +
Sbjct: 385 NMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL-PH 442
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L L+ + ELDL +N L +P+ I+ L+ L L N+++++ + N LT L +
Sbjct: 443 GLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN-LTHLGL 501
Query: 451 VGNRFTMIWRRSFFDSNPYLERLDLSDN 478
N T + N LE L L+DN
Sbjct: 502 GENLLTHLPEEIGTLEN--LEELYLNDN 527
Score = 75.8 bits (178), Expect = 5e-13
Identities = 102/419 (24%), Positives = 184/419 (43%), Gaps = 22/419 (5%)
Query: 66 KLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+L++S P S+ L L L + SN+L+ LP + L L L LS N S
Sbjct: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE-VGCLVNLMTLALSENSLTSL- 161
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
D L L++LDL NK + + ++ + SL TL L I ++ +
Sbjct: 162 ----PDSLDNLKKLRMLDLRHNKLREIPSVVYR----LDSLTTLYLRFNRITTV--EKDI 211
Query: 186 SGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L + +L + N + ++ I +L +L V++ +L L E+ +T+L + +
Sbjct: 212 KNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQH 270
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANN 303
N L+L + NL S S + + + + +L +L + L +N + L + ++
Sbjct: 271 NELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY 363
+L L L+ N + L++ N I IP L++L + N
Sbjct: 331 VKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQ 390
Query: 364 LSR--VGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NT 420
L+ + S+ L++++ +L I +D + GL S+ L LS NLL +P + +
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPED-VSGLVSLEVLILSNNLLKKLPHGLGNLRK 449
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
L+ L+L N++ S+ N + L L L + N+ T + R +N L L L +N+
Sbjct: 450 LRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN--LTHLGLGENL 505
Score = 59.3 bits (137), Expect = 5e-08
Identities = 65/267 (24%), Positives = 120/267 (44%), Gaps = 23/267 (8%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T++D L D+P+ +G +++L + N + P SL++ L L++ +N + LP
Sbjct: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLP 323
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPND----VLLPATHLKILDLSFNKFQ-----TM 152
++ L +L L L L+RN F + P+ L H +I + F F +
Sbjct: 324 ESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSK 383
Query: 153 GNLANQELLIRP-------SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
N+ + +L P S+ L L ++ I +SGL+++ VL L+ N L ++
Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKI--PEDVSGLVSLEVLILSNNLLKKLP 441
Query: 206 NLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
+ + + LR L + +L SL NE+ +L L L ++NN L +L + +
Sbjct: 442 HGLGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLG 500
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHN 290
+ + L + +L + LN N
Sbjct: 501 LGENLLTHLPEEIGTLENLEELYLNDN 527
Score = 55.6 bits (128), Expect = 6e-07
Identities = 64/205 (31%), Positives = 94/205 (45%), Gaps = 27/205 (13%)
Query: 53 LTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTA 110
LT +P G + +LN++ N+ TK PE +S L +L L +S+N LK LP + L NL
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP-HGLGNLRK 449
Query: 111 LEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM----GNLANQELLIRPSL 166
L L+L N +S PN++ L+ L L+ N+ T+ G+L N L L
Sbjct: 450 LRELDLEENKLESL----PNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN---LTHLGL 501
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLR---IQNLISSSLRSLFVSNCELT 223
+L H + L N+ L LN NP L + + S L + + NC L+
Sbjct: 502 GENLLTHLP-------EEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Query: 224 SLNHNELMFLPS--LTHLKMSNNYR 246
L + PS + LKM YR
Sbjct: 555 HLPPQIVAGGPSFIIQFLKMQGPYR 579
>AF068920-1|AAC39856.1| 582|Homo sapiens Ras-binding protein SUR-8
protein.
Length = 582
Score = 83.4 bits (197), Expect = 3e-15
Identities = 116/448 (25%), Positives = 208/448 (46%), Gaps = 40/448 (8%)
Query: 46 IDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
+D S+R + +P+ + Q+T+L + +N+ P + L NL+ L +S N L LPD
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD- 163
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIR 163
+L NL L +L+L N L P+ V+ L L L FN+ T+ +++
Sbjct: 164 SLDNLKKLRMLDLRHNK----LREIPS-VVYRLDSLTTLYLRFNRITTV----EKDIKNL 214
Query: 164 PSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELT 223
L L + +I + + + L N+ L + N L + I + + ++N +
Sbjct: 215 SKLSMLSIRENKIKQL--PAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ---ITNLD-- 267
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSL-KYIDISYCNILQPNLKGFP-S 281
L HNEL+ LP T +S+ RL L + + +SL K + N+ N+ P S
Sbjct: 268 -LQHNELLDLPD-TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPES 325
Query: 282 LRKAILNHNMVRYLESNAF--------ANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L +++ N + L N F + + + L++ +N I + + F K+L L
Sbjct: 326 LLSSLVKLNSLT-LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKL 384
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMSSCELNTIGKD 391
++ N++ +P D S+ +L L+ N L+++ S +S+ +L +S+ L +
Sbjct: 385 NMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL-PH 442
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L L+ + ELDL +N L +P+ I+ L+ L L N+++++ + N LT L +
Sbjct: 443 GLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN-LTHLGL 501
Query: 451 VGNRFTMIWRRSFFDSNPYLERLDLSDN 478
N T + N LE L L+DN
Sbjct: 502 GENLLTHLPEEIGTLEN--LEELYLNDN 527
Score = 75.8 bits (178), Expect = 5e-13
Identities = 102/419 (24%), Positives = 184/419 (43%), Gaps = 22/419 (5%)
Query: 66 KLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+L++S P S+ L L L + SN+L+ LP + L L L LS N S
Sbjct: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE-VGCLVNLMTLALSENSLTSL- 161
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
D L L++LDL NK + + ++ + SL TL L I ++ +
Sbjct: 162 ----PDSLDNLKKLRMLDLRHNKLREIPSVVYR----LDSLTTLYLRFNRITTV--EKDI 211
Query: 186 SGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L + +L + N + ++ I +L +L V++ +L L E+ +T+L + +
Sbjct: 212 KNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQH 270
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANN 303
N L+L + NL S S + + + + +L +L + L +N + L + ++
Sbjct: 271 NELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY 363
+L L L+ N + L++ N I IP L++L + N
Sbjct: 331 VKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQ 390
Query: 364 LSR--VGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NT 420
L+ + S+ L++++ +L I +D + GL S+ L LS NLL +P + +
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPED-VSGLVSLEVLILSNNLLKKLPHGLGNLRK 449
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
L+ L+L N++ S+ N + L L L + N+ T + R +N L L L +N+
Sbjct: 450 LRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN--LTHLGLGENL 505
Score = 59.3 bits (137), Expect = 5e-08
Identities = 65/267 (24%), Positives = 120/267 (44%), Gaps = 23/267 (8%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T++D L D+P+ +G +++L + N + P SL++ L L++ +N + LP
Sbjct: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLP 323
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPND----VLLPATHLKILDLSFNKFQ-----TM 152
++ L +L L L L+RN F + P+ L H +I + F F +
Sbjct: 324 ESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSK 383
Query: 153 GNLANQELLIRP-------SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
N+ + +L P S+ L L ++ I +SGL+++ VL L+ N L ++
Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKI--PEDVSGLVSLEVLILSNNLLKKLP 441
Query: 206 NLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
+ + + LR L + +L SL NE+ +L L L ++NN L +L + +
Sbjct: 442 HGLGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLG 500
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHN 290
+ + L + +L + LN N
Sbjct: 501 LGENLLTHLPEEIGTLENLEELYLNDN 527
Score = 55.6 bits (128), Expect = 6e-07
Identities = 64/205 (31%), Positives = 94/205 (45%), Gaps = 27/205 (13%)
Query: 53 LTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTA 110
LT +P G + +LN++ N+ TK PE +S L +L L +S+N LK LP + L NL
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP-HGLGNLRK 449
Query: 111 LEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM----GNLANQELLIRPSL 166
L L+L N +S PN++ L+ L L+ N+ T+ G+L N L L
Sbjct: 450 LRELDLEENKLESL----PNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN---LTHLGL 501
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLR---IQNLISSSLRSLFVSNCELT 223
+L H + L N+ L LN NP L + + S L + + NC L+
Sbjct: 502 GENLLTHLP-------EEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Query: 224 SLNHNELMFLPS--LTHLKMSNNYR 246
L + PS + LKM YR
Sbjct: 555 HLPPQIVAGGPSFIIQFLKMQGPYR 579
>AF054828-1|AAC25698.1| 582|Homo sapiens leucine-rich repeat
protein SHOC-2 protein.
Length = 582
Score = 83.4 bits (197), Expect = 3e-15
Identities = 116/448 (25%), Positives = 208/448 (46%), Gaps = 40/448 (8%)
Query: 46 IDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
+D S+R + +P+ + Q+T+L + +N+ P + L NL+ L +S N L LPD
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD- 163
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIR 163
+L NL L +L+L N L P+ V+ L L L FN+ T+ +++
Sbjct: 164 SLDNLKKLRMLDLRHNK----LREIPS-VVYRLDSLTTLYLRFNRITTV----EKDIKNL 214
Query: 164 PSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELT 223
L L + +I + + + L N+ L + N L + I + + ++N +
Sbjct: 215 SKLSMLSIRENKIKQL--PAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ---ITNLD-- 267
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSL-KYIDISYCNILQPNLKGFP-S 281
L HNEL+ LP T +S+ RL L + + +SL K + N+ N+ P S
Sbjct: 268 -LQHNELLDLPD-TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPES 325
Query: 282 LRKAILNHNMVRYLESNAF--------ANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L +++ N + L N F + + + L++ +N I + + F K+L L
Sbjct: 326 LLSSLVKLNSLT-LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKL 384
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMSSCELNTIGKD 391
++ N++ +P D S+ +L L+ N L+++ S +S+ +L +S+ L +
Sbjct: 385 NMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL-PH 442
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L L+ + ELDL +N L +P+ I+ L+ L L N+++++ + N LT L +
Sbjct: 443 GLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN-LTHLGL 501
Query: 451 VGNRFTMIWRRSFFDSNPYLERLDLSDN 478
N T + N LE L L+DN
Sbjct: 502 GENLLTHLPEEIGTLEN--LEELYLNDN 527
Score = 75.8 bits (178), Expect = 5e-13
Identities = 102/419 (24%), Positives = 184/419 (43%), Gaps = 22/419 (5%)
Query: 66 KLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+L++S P S+ L L L + SN+L+ LP + L L L LS N S
Sbjct: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE-VGCLVNLMTLALSENSLTSL- 161
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
D L L++LDL NK + + ++ + SL TL L I ++ +
Sbjct: 162 ----PDSLDNLKKLRMLDLRHNKLREIPSVVYR----LDSLTTLYLRFNRITTV--EKDI 211
Query: 186 SGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L + +L + N + ++ I +L +L V++ +L L E+ +T+L + +
Sbjct: 212 KNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQH 270
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANN 303
N L+L + NL S S + + + + +L +L + L +N + L + ++
Sbjct: 271 NELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY 363
+L L L+ N + L++ N I IP L++L + N
Sbjct: 331 VKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQ 390
Query: 364 LSR--VGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NT 420
L+ + S+ L++++ +L I +D + GL S+ L LS NLL +P + +
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPED-VSGLVSLEVLILSNNLLKKLPHGLGNLRK 449
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
L+ L+L N++ S+ N + L L L + N+ T + R +N L L L +N+
Sbjct: 450 LRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN--LTHLGLGENL 505
Score = 59.3 bits (137), Expect = 5e-08
Identities = 65/267 (24%), Positives = 120/267 (44%), Gaps = 23/267 (8%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T++D L D+P+ +G +++L + N + P SL++ L L++ +N + LP
Sbjct: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLP 323
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPND----VLLPATHLKILDLSFNKFQ-----TM 152
++ L +L L L L+RN F + P+ L H +I + F F +
Sbjct: 324 ESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSK 383
Query: 153 GNLANQELLIRP-------SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
N+ + +L P S+ L L ++ I +SGL+++ VL L+ N L ++
Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKI--PEDVSGLVSLEVLILSNNLLKKLP 441
Query: 206 NLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
+ + + LR L + +L SL NE+ +L L L ++NN L +L + +
Sbjct: 442 HGLGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLG 500
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHN 290
+ + L + +L + LN N
Sbjct: 501 LGENLLTHLPEEIGTLENLEELYLNDN 527
Score = 55.6 bits (128), Expect = 6e-07
Identities = 64/205 (31%), Positives = 94/205 (45%), Gaps = 27/205 (13%)
Query: 53 LTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTA 110
LT +P G + +LN++ N+ TK PE +S L +L L +S+N LK LP + L NL
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP-HGLGNLRK 449
Query: 111 LEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM----GNLANQELLIRPSL 166
L L+L N +S PN++ L+ L L+ N+ T+ G+L N L L
Sbjct: 450 LRELDLEENKLESL----PNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN---LTHLGL 501
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLR---IQNLISSSLRSLFVSNCELT 223
+L H + L N+ L LN NP L + + S L + + NC L+
Sbjct: 502 GENLLTHLP-------EEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Query: 224 SLNHNELMFLPS--LTHLKMSNNYR 246
L + PS + LKM YR
Sbjct: 555 HLPPQIVAGGPSFIIQFLKMQGPYR 579
>AB020669-1|BAA74885.2| 584|Homo sapiens KIAA0862 protein protein.
Length = 584
Score = 83.4 bits (197), Expect = 3e-15
Identities = 116/448 (25%), Positives = 208/448 (46%), Gaps = 40/448 (8%)
Query: 46 IDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
+D S+R + +P+ + Q+T+L + +N+ P + L NL+ L +S N L LPD
Sbjct: 107 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD- 165
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIR 163
+L NL L +L+L N L P+ V+ L L L FN+ T+ +++
Sbjct: 166 SLDNLKKLRMLDLRHNK----LREIPS-VVYRLDSLTTLYLRFNRITTV----EKDIKNL 216
Query: 164 PSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELT 223
L L + +I + + + L N+ L + N L + I + + ++N +
Sbjct: 217 SKLSMLSIRENKIKQL--PAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ---ITNLD-- 269
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSL-KYIDISYCNILQPNLKGFP-S 281
L HNEL+ LP T +S+ RL L + + +SL K + N+ N+ P S
Sbjct: 270 -LQHNELLDLPD-TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPES 327
Query: 282 LRKAILNHNMVRYLESNAF--------ANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L +++ N + L N F + + + L++ +N I + + F K+L L
Sbjct: 328 LLSSLVKLNSLT-LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKL 386
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMSSCELNTIGKD 391
++ N++ +P D S+ +L L+ N L+++ S +S+ +L +S+ L +
Sbjct: 387 NMKDNQLTSLPLD-FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL-PH 444
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L L+ + ELDL +N L +P+ I+ L+ L L N+++++ + N LT L +
Sbjct: 445 GLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN-LTHLGL 503
Query: 451 VGNRFTMIWRRSFFDSNPYLERLDLSDN 478
N T + N LE L L+DN
Sbjct: 504 GENLLTHLPEEIGTLEN--LEELYLNDN 529
Score = 75.8 bits (178), Expect = 5e-13
Identities = 102/419 (24%), Positives = 184/419 (43%), Gaps = 22/419 (5%)
Query: 66 KLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
+L++S P S+ L L L + SN+L+ LP + L L L LS N S
Sbjct: 106 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE-VGCLVNLMTLALSENSLTSL- 163
Query: 126 NLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPL 185
D L L++LDL NK + + ++ + SL TL L I ++ +
Sbjct: 164 ----PDSLDNLKKLRMLDLRHNKLREIPSVVYR----LDSLTTLYLRFNRITTV--EKDI 213
Query: 186 SGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSN 243
L + +L + N + ++ I +L +L V++ +L L E+ +T+L + +
Sbjct: 214 KNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHL-PKEIGNCTQITNLDLQH 272
Query: 244 NYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANN 303
N L+L + NL S S + + + + +L +L + L +N + L + ++
Sbjct: 273 NELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 332
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY 363
+L L L+ N + L++ N I IP L++L + N
Sbjct: 333 VKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQ 392
Query: 364 LSR--VGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NT 420
L+ + S+ L++++ +L I +D + GL S+ L LS NLL +P + +
Sbjct: 393 LTSLPLDFGTWTSMVELNLATNQLTKIPED-VSGLVSLEVLILSNNLLKKLPHGLGNLRK 451
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
L+ L+L N++ S+ N + L L L + N+ T + R +N L L L +N+
Sbjct: 452 LRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN--LTHLGLGENL 507
Score = 59.3 bits (137), Expect = 5e-08
Identities = 65/267 (24%), Positives = 120/267 (44%), Gaps = 23/267 (8%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T++D L D+P+ +G +++L + N + P SL++ L L++ +N + LP
Sbjct: 266 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLP 325
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPND----VLLPATHLKILDLSFNKFQ-----TM 152
++ L +L L L L+RN F + P+ L H +I + F F +
Sbjct: 326 ESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSK 385
Query: 153 GNLANQELLIRP-------SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
N+ + +L P S+ L L ++ I +SGL+++ VL L+ N L ++
Sbjct: 386 LNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKI--PEDVSGLVSLEVLILSNNLLKKLP 443
Query: 206 NLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
+ + + LR L + +L SL NE+ +L L L ++NN L +L + +
Sbjct: 444 HGLGNLRKLRELDLEENKLESL-PNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLG 502
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHN 290
+ + L + +L + LN N
Sbjct: 503 LGENLLTHLPEEIGTLENLEELYLNDN 529
Score = 56.4 bits (130), Expect = 3e-07
Identities = 64/205 (31%), Positives = 95/205 (46%), Gaps = 27/205 (13%)
Query: 53 LTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTA 110
LT +P G + +LN++ N+ TK PE +S L +L L +S+N LK LP + L NL
Sbjct: 393 LTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP-HGLGNLRK 451
Query: 111 LEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM----GNLANQELLIRPSL 166
L L+L N +S PN++ L+ L L+ N+ T+ G+L N L L
Sbjct: 452 LRELDLEENKLESL----PNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLTN---LTHLGL 503
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLR---IQNLISSSLRSLFVSNCELT 223
+L H + L N+ L LN NP L ++ + S L + + NC L+
Sbjct: 504 GENLLTHLP-------EEIGTLENLEELYLNDNPNLHSLPLELALCSKLSIMSIENCPLS 556
Query: 224 SLNHNELMFLPS--LTHLKMSNNYR 246
L + PS + LKM YR
Sbjct: 557 HLPPQIVAGGPSFIIQFLKMQGPYR 581
>BC042334-1|AAH42334.2| 545|Homo sapiens carboxypeptidase N,
polypeptide 2 protein.
Length = 545
Score = 82.6 bits (195), Expect = 5e-15
Identities = 88/309 (28%), Positives = 133/309 (43%), Gaps = 35/309 (11%)
Query: 186 SGLINIRVLKLNFNPLLRI-QNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
S L ++ L LNFN L + + L ++L SL + L +L +F P LTHLK
Sbjct: 118 SNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNRLQALPRR--LFQP-LTHLKTL 174
Query: 243 NNYRLELASSANNLFS-----QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLES 297
N + LA LF Q+LK + + + Q SL++ L+ N + L
Sbjct: 175 NLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPP 234
Query: 298 NAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQL 357
F+ LE L L N I L F L L L L WN + V+P P L L
Sbjct: 235 QVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGL 294
Query: 358 KLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSIS 417
L+ N +L T+ + + L ++ L LS N ++++P I
Sbjct: 295 SLTHN---------------------QLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIF 333
Query: 418 SNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDL 475
+ L L L N +++++ F L++L LS+ N+ T + FD+N L L L
Sbjct: 334 RDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL-PEGIFDTNYNLFNLAL 392
Query: 476 SDNMWRCDC 484
N W+CDC
Sbjct: 393 HGNPWQCDC 401
Score = 70.5 bits (165), Expect = 2e-11
Identities = 61/212 (28%), Positives = 96/212 (45%), Gaps = 9/212 (4%)
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+ L+ S+ N+ SL K LN NM+ L F + LE L L N + +
Sbjct: 100 EDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNRLQA 159
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-----GHLRSM 373
L F+ L LK L+L+ N +A +PE+ + SL LKLS N LS + G L S+
Sbjct: 160 LPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSL 219
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRI 431
LD S ++ + L + L L +N ++++P SI S L +L+L +N +
Sbjct: 220 QELFLD--SNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNML 277
Query: 432 SSINNLTFFMLNRLTSLSVVGNRFTMIWRRSF 463
+ F L LS+ N+ + +F
Sbjct: 278 RVLPAGLFAHTPCLVGLSLTHNQLETVAEGTF 309
Score = 67.3 bits (157), Expect = 2e-10
Identities = 91/378 (24%), Positives = 163/378 (43%), Gaps = 17/378 (4%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL 97
C+ ++ CS L +P + + FT + NL + + QL
Sbjct: 26 CDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQL 85
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLAN 157
+A L LE L ++ + S+LNL+ N + T L L L+FN + +
Sbjct: 86 CQFRPDAFGGLPRLEDLEVTGS---SFLNLSTN-IFSNLTSLGKLTLNFNMLEALPEGLF 141
Query: 158 QELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS---SSLRS 214
Q L +LE+L L + ++ R L +++ L L N L ++ + +SL++
Sbjct: 142 QHLA---ALESLHLQGNRLQALPRRL-FQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQT 197
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCNILQ 273
L +SN L+ L L SL L + +N EL + LF ++ + L
Sbjct: 198 LKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLP 257
Query: 274 PNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
++ +L L NM+R L + FA+ L L L++N + ++ TF L L+
Sbjct: 258 LSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRS 317
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIG 389
L LS+N I +P ++ L +L L N L+ + +++S + +L +S +L T+
Sbjct: 318 LMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLP 377
Query: 390 KDSLEGLQSIVELDLSQN 407
+ + ++ L L N
Sbjct: 378 EGIFDTNYNLFNLALHGN 395
>BC018370-1|AAH18370.1| 674|Homo sapiens fibronectin leucine rich
transmembrane protein 1 protein.
Length = 674
Score = 82.2 bits (194), Expect = 6e-15
Identities = 80/269 (29%), Positives = 120/269 (44%), Gaps = 15/269 (5%)
Query: 259 QSLKY-IDISYCNILQPNLKGFP-----SLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
Q LK +++ + + +L FP SLR+ L N VR + ++ A LE L L
Sbjct: 100 QDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLD 159
Query: 313 NNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPED--SLLEMPSLTQLKLSRNYLSRVG 368
+N+++ S+ D F K LK L LS N ++ IP LE L ++S L
Sbjct: 160 DNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFK 219
Query: 369 HLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNY 428
L S+ +LD + I D+ LQ++ EL L +N L+ P ++ S L+ L L
Sbjct: 220 GLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQD 279
Query: 429 NRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDEN 488
N IS I T + L L + N T + R FD L +L L +N W C C+
Sbjct: 280 NAISHIPYNTLAKMRELERLDLSNNNLTTL-PRGLFDDLGNLAQLLLRNNPWFCGCNLMW 338
Query: 489 MRDFYDFVTLEPNKKEESFNLICNSPANV 517
+RD+ N + L+C P V
Sbjct: 339 LRDWVKARAAVVNVR----GLMCQGPEKV 363
Score = 62.1 bits (144), Expect = 7e-09
Identities = 68/250 (27%), Positives = 115/250 (46%), Gaps = 16/250 (6%)
Query: 168 TLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
TL L + +IN+ L +N++V+ L N L + SLR L + + + ++
Sbjct: 85 TLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIAR 144
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLF--SQSLKYIDISYCNILQPNLKGFP-SLRK 284
+ L +P L L + +N + S + F S+ LK + +S N L G P +L +
Sbjct: 145 DSLARIPLLEKLHLDDN-SVSTVSIEEDAFADSKQLKLLFLSR-NHLSSIPSGLPHTLEE 202
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY--DTFRGLKMLKHLDLSWNEIAV 342
L+ N + + +AF L L L N +A+ R DTF L+ L L L N +A
Sbjct: 203 LRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAA 262
Query: 343 IPEDSLLEMPS--LTQLKLSRNYLSRVGH---LRSMSVTILDMSSCELNTIGKDSLEGLQ 397
P L +PS L +L L N +S + + + + LD+S+ L T+ + + L
Sbjct: 263 PP----LNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 318
Query: 398 SIVELDLSQN 407
++ +L L N
Sbjct: 319 NLAQLLLRNN 328
Score = 58.8 bits (136), Expect = 7e-08
Identities = 83/308 (26%), Positives = 132/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ RGLT IP + T L + NN+
Sbjct: 57 VCRC--DNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINN------------------- 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L ++V+ L N D + + LP + L+ L L N +T +
Sbjct: 96 --AGIPQD-LKTKVNVQVIYLYENDLDEF------PINLPRS-LRELHLQDNNVRT---I 142
Query: 156 ANQELLIRPSLETLILDHCEINSIH-GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
A L P LE L LD ++++ + +++L L+ N L I + + +L
Sbjct: 143 ARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEE 202
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNIL 272
L + + ++++ + L SL L + N L A++ FS Q+L + + ++
Sbjct: 203 LRLDDNRISTIPLHAFKGLNSLRRLVLDGNL-LANQRIADDTFSRLQNLTELSLVRNSLA 261
Query: 273 QPNLKGFPS--LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L PS L+K L N + ++ N A ELE LDLSNNN+ +L F L L
Sbjct: 262 APPLN-LPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNL 320
Query: 331 KHLDLSWN 338
L L N
Sbjct: 321 AQLLLRNN 328
Score = 32.7 bits (71), Expect = 4.9
Identities = 25/86 (29%), Positives = 39/86 (45%), Gaps = 2/86 (2%)
Query: 44 TDIDCSRRGLTDIPNGL-GLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLP 101
T++ R L P L + KL + +N + P +L+++ L LD+S+N L LP
Sbjct: 251 TELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLP 310
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNL 127
+L L L L N + NL
Sbjct: 311 RGLFDDLGNLAQLLLRNNPWFCGCNL 336
>BC008586-1|AAH08586.1| 602|Homo sapiens leucine rich repeat
containing 40 protein.
Length = 602
Score = 82.2 bits (194), Expect = 6e-15
Identities = 113/438 (25%), Positives = 200/438 (45%), Gaps = 45/438 (10%)
Query: 42 DKTDIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKG 99
D T + S L + + L L +T L+I +N+ T P ++ L NL L++S N+LK
Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 100 LPDNALYNLTALEVLNLSRNYF----DSWLNL-NPNDVLLPATHLKILDLSFNKFQTMG- 153
LP+ + NL L+ L L N + + L N D+ L HL + SF+ ++
Sbjct: 143 LPEE-ITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 154 -NLANQELLIRPS----LETLILDHCEINSIHGRSP-LSGLINIRVLKLNFNPLLRIQNL 207
NL++ EL P+ ++ L C N + P L+G+ ++ +L L N L +
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF 261
Query: 208 ISSS-LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI 266
S S L+ L V ++ L L L S+ L + +N + + +SL+ +D+
Sbjct: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEI--ILLRSLERLDL 319
Query: 267 SYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNTE--LEYL------------DL 311
S +I P G L+ L N +R + + T+ L+YL +
Sbjct: 320 SNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSES 379
Query: 312 SNNNIASLRYDT---FRGLKMLKHLDLSWNEIAVIPEDSLLEMPS--LTQLKLSRNYL-- 364
+ +L ++ + LK LD S + +IP++ + S +T + S+N L
Sbjct: 380 ATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCE 439
Query: 365 --SRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT-L 421
R+ L+ M V+ +D+S +L+ I + L LQ + LDL N L+ +P+ + S L
Sbjct: 440 IPKRMVELKEM-VSDVDLSFNKLSFISLE-LCVLQKLTFLDLRNNFLNSLPEEMESLVRL 497
Query: 422 KYLNLNYNRISSINNLTF 439
+ +NL++NR + + +
Sbjct: 498 QTINLSFNRFKMLPEVLY 515
Score = 72.9 bits (171), Expect = 4e-12
Identities = 106/428 (24%), Positives = 197/428 (46%), Gaps = 38/428 (8%)
Query: 41 LDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGL 100
L ++ C G + N + L++SNN T P S S L +LV L++SSN+LK L
Sbjct: 158 LQHNELTCISEGFEQLSN-----LEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSL 212
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
P + + L+ L+ + N ++ + P L L++L L NK + + + L
Sbjct: 213 PAE-INRMKRLKHLDCNSNLLET---IPPE--LAGMESLELLYLRRNKLRFLPEFPSCSL 266
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN--LISSSLRSLFVS 218
L+ L + +I + L L +I VL L N L + + ++ SL L +S
Sbjct: 267 -----LKELHVGENQIEMLEAEH-LKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLS 320
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLK- 277
N +++SL ++ L +L HLK L + + S+ + + + Y L+ +K
Sbjct: 321 NNDISSLPYS----LGNL-HLKFLALEGNPLRTIRREIISKGTQEV-LKY---LRSKIKD 371
Query: 278 GFPSLRKAILNHNMVRYLES--NAFANNTELEYLDLSNNNIASLRYDTFRGLK--MLKHL 333
PS ++ M ES N A T L+ LD S+ + + F +K ++ +
Sbjct: 372 DGPSQSESATETAMTLPSESRVNIHAIIT-LKILDYSDKQATLIPDEVFDAVKSNIVTSI 430
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM--SVTILDMSSCELNTIGKD 391
+ S N++ IP+ + ++ + LS N LS + + +T LD+ + LN++ +
Sbjct: 431 NFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSL-PE 489
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSI-SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
+E L + ++LS N +P+ + TL+ + ++ N++ S++ M+ LT+L +
Sbjct: 490 EMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDL 549
Query: 451 VGNRFTMI 458
N I
Sbjct: 550 QNNDLLQI 557
Score = 48.4 bits (110), Expect = 9e-05
Identities = 70/303 (23%), Positives = 133/303 (43%), Gaps = 33/303 (10%)
Query: 66 KLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L++ N+ E L L++++ LD+ N+LK +PD + L +LE L+LS N
Sbjct: 269 ELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL-LRSLERLDLSNN----- 322
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMG----NLANQELL--IR-------PSLETLIL 171
+++ L HLK L L N +T+ + QE+L +R PS
Sbjct: 323 -DISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESAT 381
Query: 172 DHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELM 231
+ R + +I +++L + I + + +++S V++ + N+L
Sbjct: 382 ETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSK---NQLC 438
Query: 232 FLPS-LTHLK-MSNNYRLELAS----SANNLFSQSLKYIDI--SYCNILQPNLKGFPSLR 283
+P + LK M ++ L S Q L ++D+ ++ N L ++ L+
Sbjct: 439 EIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQ 498
Query: 284 KAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVI 343
L+ N + L + T LE + +SNN + S+ + ++ L LDL N++ I
Sbjct: 499 TINLSFNRFKMLPEVLYRIFT-LETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQI 557
Query: 344 PED 346
P +
Sbjct: 558 PPE 560
Score = 44.0 bits (99), Expect = 0.002
Identities = 41/182 (22%), Positives = 86/182 (47%), Gaps = 13/182 (7%)
Query: 79 ESLSRLHNLVNL---DISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLP 135
ES +H ++ L D S Q +PD +++ ++ S N+ + L P ++
Sbjct: 390 ESRVNIHAIITLKILDYSDKQATLIPDE-VFDAVKSNIVT-SINFSKNQLCEIPKRMVEL 447
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
+ +DLSFNK + + EL + L L L + +NS+ + L+ ++ +
Sbjct: 448 KEMVSDVDLSFNKL----SFISLELCVLQKLTFLDLRNNFLNSLP--EEMESLVRLQTIN 501
Query: 196 LNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA 253
L+FN + ++ +L ++ +SN ++ S++ ++ + +LT L + NN L++
Sbjct: 502 LSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPEL 561
Query: 254 NN 255
N
Sbjct: 562 GN 563
>BC003407-1|AAH03407.2| 581|Homo sapiens LRRC40 protein protein.
Length = 581
Score = 82.2 bits (194), Expect = 6e-15
Identities = 113/438 (25%), Positives = 200/438 (45%), Gaps = 45/438 (10%)
Query: 42 DKTDIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKG 99
D T + S L + + L L +T L+I +N+ T P ++ L NL L++S N+LK
Sbjct: 62 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 121
Query: 100 LPDNALYNLTALEVLNLSRNYF----DSWLNL-NPNDVLLPATHLKILDLSFNKFQTMG- 153
LP+ + NL L+ L L N + + L N D+ L HL + SF+ ++
Sbjct: 122 LPEE-ITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 180
Query: 154 -NLANQELLIRPS----LETLILDHCEINSIHGRSP-LSGLINIRVLKLNFNPLLRIQNL 207
NL++ EL P+ ++ L C N + P L+G+ ++ +L L N L +
Sbjct: 181 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF 240
Query: 208 ISSS-LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI 266
S S L+ L V ++ L L L S+ L + +N + + +SL+ +D+
Sbjct: 241 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEI--ILLRSLERLDL 298
Query: 267 SYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNTE--LEYL------------DL 311
S +I P G L+ L N +R + + T+ L+YL +
Sbjct: 299 SNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSES 358
Query: 312 SNNNIASLRYDT---FRGLKMLKHLDLSWNEIAVIPEDSLLEMPS--LTQLKLSRNYL-- 364
+ +L ++ + LK LD S + +IP++ + S +T + S+N L
Sbjct: 359 ATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCE 418
Query: 365 --SRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT-L 421
R+ L+ M V+ +D+S +L+ I + L LQ + LDL N L+ +P+ + S L
Sbjct: 419 IPKRMVELKEM-VSDVDLSFNKLSFISLE-LCVLQKLTFLDLRNNFLNSLPEEMESLVRL 476
Query: 422 KYLNLNYNRISSINNLTF 439
+ +NL++NR + + +
Sbjct: 477 QTINLSFNRFKMLPEVLY 494
Score = 72.9 bits (171), Expect = 4e-12
Identities = 106/428 (24%), Positives = 197/428 (46%), Gaps = 38/428 (8%)
Query: 41 LDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGL 100
L ++ C G + N + L++SNN T P S S L +LV L++SSN+LK L
Sbjct: 137 LQHNELTCISEGFEQLSN-----LEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSL 191
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
P + + L+ L+ + N ++ + P L L++L L NK + + + L
Sbjct: 192 PAE-INRMKRLKHLDCNSNLLET---IPPE--LAGMESLELLYLRRNKLRFLPEFPSCSL 245
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN--LISSSLRSLFVS 218
L+ L + +I + L L +I VL L N L + + ++ SL L +S
Sbjct: 246 -----LKELHVGENQIEMLEAEH-LKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLS 299
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLK- 277
N +++SL ++ L +L HLK L + + S+ + + + Y L+ +K
Sbjct: 300 NNDISSLPYS----LGNL-HLKFLALEGNPLRTIRREIISKGTQEV-LKY---LRSKIKD 350
Query: 278 GFPSLRKAILNHNMVRYLES--NAFANNTELEYLDLSNNNIASLRYDTFRGLK--MLKHL 333
PS ++ M ES N A T L+ LD S+ + + F +K ++ +
Sbjct: 351 DGPSQSESATETAMTLPSESRVNIHAIIT-LKILDYSDKQATLIPDEVFDAVKSNIVTSI 409
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM--SVTILDMSSCELNTIGKD 391
+ S N++ IP+ + ++ + LS N LS + + +T LD+ + LN++ +
Sbjct: 410 NFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSL-PE 468
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSI-SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
+E L + ++LS N +P+ + TL+ + ++ N++ S++ M+ LT+L +
Sbjct: 469 EMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDL 528
Query: 451 VGNRFTMI 458
N I
Sbjct: 529 QNNDLLQI 536
Score = 48.4 bits (110), Expect = 9e-05
Identities = 70/303 (23%), Positives = 133/303 (43%), Gaps = 33/303 (10%)
Query: 66 KLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L++ N+ E L L++++ LD+ N+LK +PD + L +LE L+LS N
Sbjct: 248 ELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL-LRSLERLDLSNN----- 301
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMG----NLANQELL--IR-------PSLETLIL 171
+++ L HLK L L N +T+ + QE+L +R PS
Sbjct: 302 -DISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESAT 360
Query: 172 DHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELM 231
+ R + +I +++L + I + + +++S V++ + N+L
Sbjct: 361 ETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSK---NQLC 417
Query: 232 FLPS-LTHLK-MSNNYRLELAS----SANNLFSQSLKYIDI--SYCNILQPNLKGFPSLR 283
+P + LK M ++ L S Q L ++D+ ++ N L ++ L+
Sbjct: 418 EIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQ 477
Query: 284 KAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVI 343
L+ N + L + T LE + +SNN + S+ + ++ L LDL N++ I
Sbjct: 478 TINLSFNRFKMLPEVLYRIFT-LETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQI 536
Query: 344 PED 346
P +
Sbjct: 537 PPE 539
Score = 44.0 bits (99), Expect = 0.002
Identities = 41/182 (22%), Positives = 86/182 (47%), Gaps = 13/182 (7%)
Query: 79 ESLSRLHNLVNL---DISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLP 135
ES +H ++ L D S Q +PD +++ ++ S N+ + L P ++
Sbjct: 369 ESRVNIHAIITLKILDYSDKQATLIPDE-VFDAVKSNIVT-SINFSKNQLCEIPKRMVEL 426
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
+ +DLSFNK + + EL + L L L + +NS+ + L+ ++ +
Sbjct: 427 KEMVSDVDLSFNKL----SFISLELCVLQKLTFLDLRNNFLNSLP--EEMESLVRLQTIN 480
Query: 196 LNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA 253
L+FN + ++ +L ++ +SN ++ S++ ++ + +LT L + NN L++
Sbjct: 481 LSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPEL 540
Query: 254 NN 255
N
Sbjct: 541 GN 542
>AY358308-1|AAQ88675.1| 674|Homo sapiens FLRT1 protein.
Length = 674
Score = 82.2 bits (194), Expect = 6e-15
Identities = 80/269 (29%), Positives = 120/269 (44%), Gaps = 15/269 (5%)
Query: 259 QSLKY-IDISYCNILQPNLKGFP-----SLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
Q LK +++ + + +L FP SLR+ L N VR + ++ A LE L L
Sbjct: 100 QDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLD 159
Query: 313 NNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPED--SLLEMPSLTQLKLSRNYLSRVG 368
+N+++ S+ D F K LK L LS N ++ IP LE L ++S L
Sbjct: 160 DNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFK 219
Query: 369 HLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNY 428
L S+ +LD + I D+ LQ++ EL L +N L+ P ++ S L+ L L
Sbjct: 220 GLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQD 279
Query: 429 NRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDEN 488
N IS I T + L L + N T + R FD L +L L +N W C C+
Sbjct: 280 NAISHIPYNTLAKMRELERLDLSNNNLTTL-PRGLFDDLGNLAQLLLRNNPWFCGCNLMW 338
Query: 489 MRDFYDFVTLEPNKKEESFNLICNSPANV 517
+RD+ N + L+C P V
Sbjct: 339 LRDWVKARAAVVNVR----GLMCQGPEKV 363
Score = 62.1 bits (144), Expect = 7e-09
Identities = 68/250 (27%), Positives = 115/250 (46%), Gaps = 16/250 (6%)
Query: 168 TLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
TL L + +IN+ L +N++V+ L N L + SLR L + + + ++
Sbjct: 85 TLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIAR 144
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLF--SQSLKYIDISYCNILQPNLKGFP-SLRK 284
+ L +P L L + +N + S + F S+ LK + +S N L G P +L +
Sbjct: 145 DSLARIPLLEKLHLDDN-SVSTVSIEEDAFADSKQLKLLFLSR-NHLSSIPSGLPHTLEE 202
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY--DTFRGLKMLKHLDLSWNEIAV 342
L+ N + + +AF L L L N +A+ R DTF L+ L L L N +A
Sbjct: 203 LRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAA 262
Query: 343 IPEDSLLEMPS--LTQLKLSRNYLSRVGH---LRSMSVTILDMSSCELNTIGKDSLEGLQ 397
P L +PS L +L L N +S + + + + LD+S+ L T+ + + L
Sbjct: 263 PP----LNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 318
Query: 398 SIVELDLSQN 407
++ +L L N
Sbjct: 319 NLAQLLLRNN 328
Score = 58.8 bits (136), Expect = 7e-08
Identities = 83/308 (26%), Positives = 132/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ RGLT IP + T L + NN+
Sbjct: 57 VCRC--DNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINN------------------- 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L ++V+ L N D + + LP + L+ L L N +T +
Sbjct: 96 --AGIPQD-LKTKVNVQVIYLYENDLDEF------PINLPRS-LRELHLQDNNVRT---I 142
Query: 156 ANQELLIRPSLETLILDHCEINSIH-GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
A L P LE L LD ++++ + +++L L+ N L I + + +L
Sbjct: 143 ARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEE 202
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNIL 272
L + + ++++ + L SL L + N L A++ FS Q+L + + ++
Sbjct: 203 LRLDDNRISTIPLHAFKGLNSLRRLVLDGNL-LANQRIADDTFSRLQNLTELSLVRNSLA 261
Query: 273 QPNLKGFPS--LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L PS L+K L N + ++ N A ELE LDLSNNN+ +L F L L
Sbjct: 262 APPLN-LPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNL 320
Query: 331 KHLDLSWN 338
L L N
Sbjct: 321 AQLLLRNN 328
Score = 32.7 bits (71), Expect = 4.9
Identities = 25/86 (29%), Positives = 39/86 (45%), Gaps = 2/86 (2%)
Query: 44 TDIDCSRRGLTDIPNGL-GLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLP 101
T++ R L P L + KL + +N + P +L+++ L LD+S+N L LP
Sbjct: 251 TELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLP 310
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNL 127
+L L L L N + NL
Sbjct: 311 RGLFDDLGNLAQLLLRNNPWFCGCNL 336
>AL353771-3|CAI22332.1| 602|Homo sapiens leucine rich repeat
containing 40 protein.
Length = 602
Score = 82.2 bits (194), Expect = 6e-15
Identities = 113/438 (25%), Positives = 200/438 (45%), Gaps = 45/438 (10%)
Query: 42 DKTDIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKG 99
D T + S L + + L L +T L+I +N+ T P ++ L NL L++S N+LK
Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 100 LPDNALYNLTALEVLNLSRNYF----DSWLNL-NPNDVLLPATHLKILDLSFNKFQTMG- 153
LP+ + NL L+ L L N + + L N D+ L HL + SF+ ++
Sbjct: 143 LPEE-ITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 154 -NLANQELLIRPS----LETLILDHCEINSIHGRSP-LSGLINIRVLKLNFNPLLRIQNL 207
NL++ EL P+ ++ L C N + P L+G+ ++ +L L N L +
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF 261
Query: 208 ISSS-LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI 266
S S L+ L V ++ L L L S+ L + +N + + +SL+ +D+
Sbjct: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEI--ILLRSLERLDL 319
Query: 267 SYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNTE--LEYL------------DL 311
S +I P G L+ L N +R + + T+ L+YL +
Sbjct: 320 SNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSES 379
Query: 312 SNNNIASLRYDT---FRGLKMLKHLDLSWNEIAVIPEDSLLEMPS--LTQLKLSRNYL-- 364
+ +L ++ + LK LD S + +IP++ + S +T + S+N L
Sbjct: 380 ATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCE 439
Query: 365 --SRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT-L 421
R+ L+ M V+ +D+S +L+ I + L LQ + LDL N L+ +P+ + S L
Sbjct: 440 IPKRMVELKEM-VSDVDLSFNKLSFISLE-LCVLQKLTFLDLRNNFLNSLPEEMESLVRL 497
Query: 422 KYLNLNYNRISSINNLTF 439
+ +NL++NR + + +
Sbjct: 498 QTINLSFNRFKMLPEVLY 515
Score = 72.9 bits (171), Expect = 4e-12
Identities = 106/428 (24%), Positives = 197/428 (46%), Gaps = 38/428 (8%)
Query: 41 LDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGL 100
L ++ C G + N + L++SNN T P S S L +LV L++SSN+LK L
Sbjct: 158 LQHNELTCISEGFEQLSN-----LEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSL 212
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
P + + L+ L+ + N ++ + P L L++L L NK + + + L
Sbjct: 213 PAE-INRMKRLKHLDCNSNLLET---IPPE--LAGMESLELLYLRRNKLRFLPEFPSCSL 266
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN--LISSSLRSLFVS 218
L+ L + +I + L L +I VL L N L + + ++ SL L +S
Sbjct: 267 -----LKELHVGENQIEMLEAEH-LKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLS 320
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLK- 277
N +++SL ++ L +L HLK L + + S+ + + + Y L+ +K
Sbjct: 321 NNDISSLPYS----LGNL-HLKFLALEGNPLRTIRREIISKGTQEV-LKY---LRSKIKD 371
Query: 278 GFPSLRKAILNHNMVRYLES--NAFANNTELEYLDLSNNNIASLRYDTFRGLK--MLKHL 333
PS ++ M ES N A T L+ LD S+ + + F +K ++ +
Sbjct: 372 DGPSQSESATETAMTLPSESRVNIHAIIT-LKILDYSDKQATLIPDEVFDAVKSNIVTSI 430
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM--SVTILDMSSCELNTIGKD 391
+ S N++ IP+ + ++ + LS N LS + + +T LD+ + LN++ +
Sbjct: 431 NFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSL-PE 489
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSI-SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
+E L + ++LS N +P+ + TL+ + ++ N++ S++ M+ LT+L +
Sbjct: 490 EMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDL 549
Query: 451 VGNRFTMI 458
N I
Sbjct: 550 QNNDLLQI 557
Score = 48.4 bits (110), Expect = 9e-05
Identities = 70/303 (23%), Positives = 133/303 (43%), Gaps = 33/303 (10%)
Query: 66 KLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L++ N+ E L L++++ LD+ N+LK +PD + L +LE L+LS N
Sbjct: 269 ELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL-LRSLERLDLSNN----- 322
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMG----NLANQELL--IR-------PSLETLIL 171
+++ L HLK L L N +T+ + QE+L +R PS
Sbjct: 323 -DISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESAT 381
Query: 172 DHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELM 231
+ R + +I +++L + I + + +++S V++ + N+L
Sbjct: 382 ETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSK---NQLC 438
Query: 232 FLPS-LTHLK-MSNNYRLELAS----SANNLFSQSLKYIDI--SYCNILQPNLKGFPSLR 283
+P + LK M ++ L S Q L ++D+ ++ N L ++ L+
Sbjct: 439 EIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQ 498
Query: 284 KAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVI 343
L+ N + L + T LE + +SNN + S+ + ++ L LDL N++ I
Sbjct: 499 TINLSFNRFKMLPEVLYRIFT-LETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQI 557
Query: 344 PED 346
P +
Sbjct: 558 PPE 560
Score = 44.0 bits (99), Expect = 0.002
Identities = 41/182 (22%), Positives = 86/182 (47%), Gaps = 13/182 (7%)
Query: 79 ESLSRLHNLVNL---DISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLP 135
ES +H ++ L D S Q +PD +++ ++ S N+ + L P ++
Sbjct: 390 ESRVNIHAIITLKILDYSDKQATLIPDE-VFDAVKSNIVT-SINFSKNQLCEIPKRMVEL 447
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
+ +DLSFNK + + EL + L L L + +NS+ + L+ ++ +
Sbjct: 448 KEMVSDVDLSFNKL----SFISLELCVLQKLTFLDLRNNFLNSLP--EEMESLVRLQTIN 501
Query: 196 LNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA 253
L+FN + ++ +L ++ +SN ++ S++ ++ + +LT L + NN L++
Sbjct: 502 LSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPEL 561
Query: 254 NN 255
N
Sbjct: 562 GN 563
>AK022951-1|BAB14326.1| 602|Homo sapiens protein ( Homo sapiens
cDNA FLJ12889 fis, clone NT2RP2004098, weakly similar to
ADENYLATE CYCLASE (EC 4.6.1.1). ).
Length = 602
Score = 82.2 bits (194), Expect = 6e-15
Identities = 113/438 (25%), Positives = 200/438 (45%), Gaps = 45/438 (10%)
Query: 42 DKTDIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKG 99
D T + S L + + L L +T L+I +N+ T P ++ L NL L++S N+LK
Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 100 LPDNALYNLTALEVLNLSRNYF----DSWLNL-NPNDVLLPATHLKILDLSFNKFQTMG- 153
LP+ + NL L+ L L N + + L N D+ L HL + SF+ ++
Sbjct: 143 LPEE-ITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 154 -NLANQELLIRPS----LETLILDHCEINSIHGRSP-LSGLINIRVLKLNFNPLLRIQNL 207
NL++ EL P+ ++ L C N + P L+G+ ++ +L L N L +
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF 261
Query: 208 ISSS-LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI 266
S S L+ L V ++ L L L S+ L + +N + + +SL+ +D+
Sbjct: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEI--ILLRSLERLDL 319
Query: 267 SYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNTE--LEYL------------DL 311
S +I P G L+ L N +R + + T+ L+YL +
Sbjct: 320 SNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSES 379
Query: 312 SNNNIASLRYDT---FRGLKMLKHLDLSWNEIAVIPEDSLLEMPS--LTQLKLSRNYL-- 364
+ +L ++ + LK LD S + +IP++ + S +T + S+N L
Sbjct: 380 ATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCE 439
Query: 365 --SRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT-L 421
R+ L+ M V+ +D+S +L+ I + L LQ + LDL N L+ +P+ + S L
Sbjct: 440 IPKRMVELKEM-VSDVDLSFNKLSFISLE-LCVLQKLTFLDLRNNFLNSLPEEMESLVRL 497
Query: 422 KYLNLNYNRISSINNLTF 439
+ +NL++NR + + +
Sbjct: 498 QTINLSFNRFKMLPEVLY 515
Score = 72.9 bits (171), Expect = 4e-12
Identities = 106/428 (24%), Positives = 197/428 (46%), Gaps = 38/428 (8%)
Query: 41 LDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGL 100
L ++ C G + N + L++SNN T P S S L +LV L++SSN+LK L
Sbjct: 158 LQHNELTCISEGFEQLSN-----LEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSL 212
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
P + + L+ L+ + N ++ + P L L++L L NK + + + L
Sbjct: 213 PAE-INRMKRLKHLDCNSNLLET---IPPE--LAGMESLELLYLRRNKLRFLPEFPSCSL 266
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN--LISSSLRSLFVS 218
L+ L + +I + L L +I VL L N L + + ++ SL L +S
Sbjct: 267 -----LKELHVGENQIEMLEAEH-LKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLS 320
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLK- 277
N +++SL ++ L +L HLK L + + S+ + + + Y L+ +K
Sbjct: 321 NNDISSLPYS----LGNL-HLKFLALEGNPLRTIRREIISKGTQEV-LKY---LRSKIKD 371
Query: 278 GFPSLRKAILNHNMVRYLES--NAFANNTELEYLDLSNNNIASLRYDTFRGLK--MLKHL 333
PS ++ M ES N A T L+ LD S+ + + F +K ++ +
Sbjct: 372 DGPSQSESATETAMTLPSESRVNIHAIIT-LKILDYSDKQATLIPDEVFDAVKSNIVTSI 430
Query: 334 DLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM--SVTILDMSSCELNTIGKD 391
+ S N++ IP+ + ++ + LS N LS + + +T LD+ + LN++ +
Sbjct: 431 NFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSL-PE 489
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSI-SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
+E L + ++LS N +P+ + TL+ + ++ N++ S++ M+ LT+L +
Sbjct: 490 EMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDL 549
Query: 451 VGNRFTMI 458
N I
Sbjct: 550 QNNDLLQI 557
Score = 48.4 bits (110), Expect = 9e-05
Identities = 70/303 (23%), Positives = 133/303 (43%), Gaps = 33/303 (10%)
Query: 66 KLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L++ N+ E L L++++ LD+ N+LK +PD + L +LE L+LS N
Sbjct: 269 ELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL-LRSLERLDLSNN----- 322
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMG----NLANQELL--IR-------PSLETLIL 171
+++ L HLK L L N +T+ + QE+L +R PS
Sbjct: 323 -DISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESAT 381
Query: 172 DHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELM 231
+ R + +I +++L + I + + +++S V++ + N+L
Sbjct: 382 ETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSK---NQLC 438
Query: 232 FLPS-LTHLK-MSNNYRLELAS----SANNLFSQSLKYIDI--SYCNILQPNLKGFPSLR 283
+P + LK M ++ L S Q L ++D+ ++ N L ++ L+
Sbjct: 439 EIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQ 498
Query: 284 KAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVI 343
L+ N + L + T LE + +SNN + S+ + ++ L LDL N++ I
Sbjct: 499 TINLSFNRFKMLPEVLYRIFT-LETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQI 557
Query: 344 PED 346
P +
Sbjct: 558 PPE 560
Score = 44.0 bits (99), Expect = 0.002
Identities = 41/182 (22%), Positives = 86/182 (47%), Gaps = 13/182 (7%)
Query: 79 ESLSRLHNLVNL---DISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLP 135
ES +H ++ L D S Q +PD +++ ++ S N+ + L P ++
Sbjct: 390 ESRVNIHAIITLKILDYSDKQATLIPDE-VFDAVKSNIVT-SINFSKNQLCEIPKRMVEL 447
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
+ +DLSFNK + + EL + L L L + +NS+ + L+ ++ +
Sbjct: 448 KEMVSDVDLSFNKL----SFISLELCVLQKLTFLDLRNNFLNSLP--EEMESLVRLQTIN 501
Query: 196 LNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA 253
L+FN + ++ +L ++ +SN ++ S++ ++ + +LT L + NN L++
Sbjct: 502 LSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPEL 561
Query: 254 NN 255
N
Sbjct: 562 GN 563
>AF169675-1|AAF28459.1| 674|Homo sapiens leucine-rich repeat
transmembrane protein FLRT1 protein.
Length = 674
Score = 82.2 bits (194), Expect = 6e-15
Identities = 80/269 (29%), Positives = 120/269 (44%), Gaps = 15/269 (5%)
Query: 259 QSLKY-IDISYCNILQPNLKGFP-----SLRKAILNHNMVRYLESNAFANNTELEYLDLS 312
Q LK +++ + + +L FP SLR+ L N VR + ++ A LE L L
Sbjct: 100 QDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLD 159
Query: 313 NNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPED--SLLEMPSLTQLKLSRNYLSRVG 368
+N+++ S+ D F K LK L LS N ++ IP LE L ++S L
Sbjct: 160 DNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFK 219
Query: 369 HLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNY 428
L S+ +LD + I D+ LQ++ EL L +N L+ P ++ S L+ L L
Sbjct: 220 GLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQD 279
Query: 429 NRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDEN 488
N IS I T + L L + N T + R FD L +L L +N W C C+
Sbjct: 280 NAISHIPYNTLAKMRELERLDLSNNNLTTL-PRGLFDDLGNLAQLLLRNNPWFCGCNLMW 338
Query: 489 MRDFYDFVTLEPNKKEESFNLICNSPANV 517
+RD+ N + L+C P V
Sbjct: 339 LRDWVKARAAVVNVR----GLMCQGPEKV 363
Score = 62.1 bits (144), Expect = 7e-09
Identities = 68/250 (27%), Positives = 115/250 (46%), Gaps = 16/250 (6%)
Query: 168 TLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
TL L + +IN+ L +N++V+ L N L + SLR L + + + ++
Sbjct: 85 TLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIAR 144
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLF--SQSLKYIDISYCNILQPNLKGFP-SLRK 284
+ L +P L L + +N + S + F S+ LK + +S N L G P +L +
Sbjct: 145 DSLARIPLLEKLHLDDN-SVSTVSIEEDAFADSKQLKLLFLSR-NHLSSIPSGLPHTLEE 202
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY--DTFRGLKMLKHLDLSWNEIAV 342
L+ N + + +AF L L L N +A+ R DTF L+ L L L N +A
Sbjct: 203 LRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAA 262
Query: 343 IPEDSLLEMPS--LTQLKLSRNYLSRVGH---LRSMSVTILDMSSCELNTIGKDSLEGLQ 397
P L +PS L +L L N +S + + + + LD+S+ L T+ + + L
Sbjct: 263 PP----LNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 318
Query: 398 SIVELDLSQN 407
++ +L L N
Sbjct: 319 NLAQLLLRNN 328
Score = 58.8 bits (136), Expect = 7e-08
Identities = 83/308 (26%), Positives = 132/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ RGLT IP + T L + NN+
Sbjct: 57 VCRC--DNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINN------------------- 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L ++V+ L N D + + LP + L+ L L N +T +
Sbjct: 96 --AGIPQD-LKTKVNVQVIYLYENDLDEF------PINLPRS-LRELHLQDNNVRT---I 142
Query: 156 ANQELLIRPSLETLILDHCEINSIH-GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
A L P LE L LD ++++ + +++L L+ N L I + + +L
Sbjct: 143 ARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEE 202
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNIL 272
L + + ++++ + L SL L + N L A++ FS Q+L + + ++
Sbjct: 203 LRLDDNRISTIPLHAFKGLNSLRRLVLDGNL-LANQRIADDTFSRLQNLTELSLVRNSLA 261
Query: 273 QPNLKGFPS--LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L PS L+K L N + ++ N A ELE LDLSNNN+ +L F L L
Sbjct: 262 APPLN-LPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNL 320
Query: 331 KHLDLSWN 338
L L N
Sbjct: 321 AQLLLRNN 328
Score = 32.7 bits (71), Expect = 4.9
Identities = 25/86 (29%), Positives = 39/86 (45%), Gaps = 2/86 (2%)
Query: 44 TDIDCSRRGLTDIPNGL-GLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLP 101
T++ R L P L + KL + +N + P +L+++ L LD+S+N L LP
Sbjct: 251 TELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLP 310
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNL 127
+L L L L N + NL
Sbjct: 311 RGLFDDLGNLAQLLLRNNPWFCGCNL 336
>BC035133-1|AAH35133.1| 708|Homo sapiens leucine rich repeat
neuronal 3 protein.
Length = 708
Score = 81.8 bits (193), Expect = 8e-15
Identities = 75/307 (24%), Positives = 145/307 (47%), Gaps = 14/307 (4%)
Query: 190 NIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
N ++L L N + +I+ +L SL +S L+S+ + + +P L + + N
Sbjct: 70 NTQILLLQTNNIAKIEYSTDFPVNLTSLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
Query: 248 ELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
EL + L + YI+ + + + P G +L + LN N ++ + S F
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N I ++ F+ L L+ L ++ + IP+++L+ + +L + N L
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 366 RVGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP-DSISSNTL 421
+V H+ + +++ LD++ +N I + + + EL ++ N+ I DS++ + L
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGIN-NMPELISIDSLAVDNL 308
Query: 422 KYLN----LNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSD 477
L N R+S I+ FF L +L SL + N + ++ + +S P L+ + +
Sbjct: 309 PDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTI-ESLPNLKEISIHS 367
Query: 478 NMWRCDC 484
N RCDC
Sbjct: 368 NPIRCDC 374
Score = 59.3 bits (137), Expect = 5e-08
Identities = 72/295 (24%), Positives = 135/295 (45%), Gaps = 20/295 (6%)
Query: 54 TDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALE 112
TD P + +T L++S N + ++ ++ L+++ + N+L LP+ L L+ L+
Sbjct: 88 TDFP----VNLTSLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQ 143
Query: 113 VLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD 172
L ++ N + ++P + +L L L+ N+ Q + + L P+LE L++
Sbjct: 144 ELYINHNLLST---ISPG-AFIGLHNLLRLHLNSNRLQMINSKWFDAL---PNLEILMIG 196
Query: 173 HCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN--LIS-SSLRSLFVSNCELTSLNHNE 229
I I + LIN+R L + L I + L+ +L S+ + L + H
Sbjct: 197 ENPIIRIKDMN-FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
Query: 230 LMFLPSLTHLKMSNN--YRLELASSANNLFSQSLKYIDI-SYCNILQPNLKGFPSLRK-A 285
L + +L L ++ N R+ +N L + L ++ +I + P LRK
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
Query: 286 ILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
N+ + Y+ NAF +LE L L++N +++L + T L LK + + N I
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPI 370
Score = 44.4 bits (100), Expect = 0.002
Identities = 61/254 (24%), Positives = 119/254 (46%), Gaps = 23/254 (9%)
Query: 53 LTDIPNGLGLQVTKLN---ISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT++P +++ L I++N + P + LHNL+ L ++SN+L+ + L
Sbjct: 128 LTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDAL 187
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
LE+L + N ++N P +L+ L ++ + + + L+ +LE+
Sbjct: 188 PNLEILMIGENPIIRIKDMN----FKPLINLRSLVIA---GINLTEIPDNALVGLENLES 240
Query: 169 L-ILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSS---LRSLFVSNC-ELT 223
+ D+ I H L ++N++ L LN NP+ RI+ S+ L+ L ++N EL
Sbjct: 241 ISFYDNRLIKVPH--VALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELI 298
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS----QSLKYIDISYCNILQPNLKGF 279
S++ + LP L ++ +NN RL N F +SL + + ++
Sbjct: 299 SIDSLAVDNLPDLRKIEATNNPRLSYI-HPNAFFRLPKLESLMLNSNALSALYHGTIESL 357
Query: 280 PSLRKAILNHNMVR 293
P+L++ ++ N +R
Sbjct: 358 PNLKEISIHSNPIR 371
>CR457397-1|CAG33678.1| 708|Homo sapiens LRRN3 protein.
Length = 708
Score = 80.2 bits (189), Expect = 2e-14
Identities = 74/307 (24%), Positives = 144/307 (46%), Gaps = 14/307 (4%)
Query: 190 NIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
N ++L L N + +I+ +L L +S L+S+ + + +P L + + N
Sbjct: 70 NTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
Query: 248 ELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
EL + L + YI+ + + + P G +L + LN N ++ + S F
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N I ++ F+ L L+ L ++ + IP+++L+ + +L + N L
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 366 RVGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP-DSISSNTL 421
+V H+ + +++ LD++ +N I + + + EL ++ N+ I DS++ + L
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGIN-NMPELISIDSLAVDNL 308
Query: 422 KYLN----LNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSD 477
L N R+S I+ FF L +L SL + N + ++ + +S P L+ + +
Sbjct: 309 PDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTI-ESLPNLKEISIHS 367
Query: 478 NMWRCDC 484
N RCDC
Sbjct: 368 NPIRCDC 374
Score = 58.4 bits (135), Expect = 9e-08
Identities = 72/295 (24%), Positives = 135/295 (45%), Gaps = 20/295 (6%)
Query: 54 TDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALE 112
TD P + +T L++S N + ++ ++ L+++ + N+L LP+ L L+ L+
Sbjct: 88 TDFP----VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQ 143
Query: 113 VLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD 172
L ++ N + ++P + +L L L+ N+ Q + + L P+LE L++
Sbjct: 144 ELYINHNLLST---ISPG-AFIGLHNLLRLHLNSNRLQMINSKWFDAL---PNLEILMIG 196
Query: 173 HCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN--LIS-SSLRSLFVSNCELTSLNHNE 229
I I + LIN+R L + L I + L+ +L S+ + L + H
Sbjct: 197 ENPIIRIKDMN-FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
Query: 230 LMFLPSLTHLKMSNN--YRLELASSANNLFSQSLKYIDI-SYCNILQPNLKGFPSLRK-A 285
L + +L L ++ N R+ +N L + L ++ +I + P LRK
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
Query: 286 ILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
N+ + Y+ NAF +LE L L++N +++L + T L LK + + N I
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPI 370
Score = 44.4 bits (100), Expect = 0.002
Identities = 61/254 (24%), Positives = 119/254 (46%), Gaps = 23/254 (9%)
Query: 53 LTDIPNGLGLQVTKLN---ISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT++P +++ L I++N + P + LHNL+ L ++SN+L+ + L
Sbjct: 128 LTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDAL 187
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
LE+L + N ++N P +L+ L ++ + + + L+ +LE+
Sbjct: 188 PNLEILMIGENPIIRIKDMN----FKPLINLRSLVIA---GINLTEIPDNALVGLENLES 240
Query: 169 L-ILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSS---LRSLFVSNC-ELT 223
+ D+ I H L ++N++ L LN NP+ RI+ S+ L+ L ++N EL
Sbjct: 241 ISFYDNRLIKVPH--VALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELI 298
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS----QSLKYIDISYCNILQPNLKGF 279
S++ + LP L ++ +NN RL N F +SL + + ++
Sbjct: 299 SIDSLAVDNLPDLRKIEATNNPRLSYI-HPNAFFRLPKLESLMLNSNALSALYHGTIESL 357
Query: 280 PSLRKAILNHNMVR 293
P+L++ ++ N +R
Sbjct: 358 PNLKEISIHSNPIR 371
>AY358280-1|AAQ88647.1| 708|Homo sapiens LRRN3 protein.
Length = 708
Score = 80.2 bits (189), Expect = 2e-14
Identities = 74/307 (24%), Positives = 144/307 (46%), Gaps = 14/307 (4%)
Query: 190 NIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
N ++L L N + +I+ +L L +S L+S+ + + +P L + + N
Sbjct: 70 NTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
Query: 248 ELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
EL + L + YI+ + + + P G +L + LN N ++ + S F
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N I ++ F+ L L+ L ++ + IP+++L+ + +L + N L
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 366 RVGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP-DSISSNTL 421
+V H+ + +++ LD++ +N I + + + EL ++ N+ I DS++ + L
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGIN-NMPELISIDSLAVDNL 308
Query: 422 KYLN----LNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSD 477
L N R+S I+ FF L +L SL + N + ++ + +S P L+ + +
Sbjct: 309 PDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTI-ESLPNLKEISIHS 367
Query: 478 NMWRCDC 484
N RCDC
Sbjct: 368 NPIRCDC 374
Score = 58.4 bits (135), Expect = 9e-08
Identities = 72/295 (24%), Positives = 135/295 (45%), Gaps = 20/295 (6%)
Query: 54 TDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALE 112
TD P + +T L++S N + ++ ++ L+++ + N+L LP+ L L+ L+
Sbjct: 88 TDFP----VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQ 143
Query: 113 VLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD 172
L ++ N + ++P + +L L L+ N+ Q + + L P+LE L++
Sbjct: 144 ELYINHNLLST---ISPG-AFIGLHNLLRLHLNSNRLQMINSKWFDAL---PNLEILMIG 196
Query: 173 HCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN--LIS-SSLRSLFVSNCELTSLNHNE 229
I I + LIN+R L + L I + L+ +L S+ + L + H
Sbjct: 197 ENPIIRIKDMN-FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
Query: 230 LMFLPSLTHLKMSNN--YRLELASSANNLFSQSLKYIDI-SYCNILQPNLKGFPSLRK-A 285
L + +L L ++ N R+ +N L + L ++ +I + P LRK
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
Query: 286 ILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
N+ + Y+ NAF +LE L L++N +++L + T L LK + + N I
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPI 370
Score = 44.4 bits (100), Expect = 0.002
Identities = 61/254 (24%), Positives = 119/254 (46%), Gaps = 23/254 (9%)
Query: 53 LTDIPNGLGLQVTKLN---ISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT++P +++ L I++N + P + LHNL+ L ++SN+L+ + L
Sbjct: 128 LTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDAL 187
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
LE+L + N ++N P +L+ L ++ + + + L+ +LE+
Sbjct: 188 PNLEILMIGENPIIRIKDMN----FKPLINLRSLVIA---GINLTEIPDNALVGLENLES 240
Query: 169 L-ILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSS---LRSLFVSNC-ELT 223
+ D+ I H L ++N++ L LN NP+ RI+ S+ L+ L ++N EL
Sbjct: 241 ISFYDNRLIKVPH--VALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELI 298
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS----QSLKYIDISYCNILQPNLKGF 279
S++ + LP L ++ +NN RL N F +SL + + ++
Sbjct: 299 SIDSLAVDNLPDLRKIEATNNPRLSYI-HPNAFFRLPKLESLMLNSNALSALYHGTIESL 357
Query: 280 PSLRKAILNHNMVR 293
P+L++ ++ N +R
Sbjct: 358 PNLKEISIHSNPIR 371
>AF134481-1|AAP97258.1| 708|Homo sapiens leucine-rich repeat
protein protein.
Length = 708
Score = 80.2 bits (189), Expect = 2e-14
Identities = 74/307 (24%), Positives = 144/307 (46%), Gaps = 14/307 (4%)
Query: 190 NIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
N ++L L N + +I+ +L L +S L+S+ + + +P L + + N
Sbjct: 70 NTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
Query: 248 ELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
EL + L + YI+ + + + P G +L + LN N ++ + S F
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N I ++ F+ L L+ L ++ + IP+++L+ + +L + N L
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 366 RVGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP-DSISSNTL 421
+V H+ + +++ LD++ +N I + + + EL ++ N+ I DS++ + L
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGIN-NMPELISIDSLAVDNL 308
Query: 422 KYLN----LNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSD 477
L N R+S I+ FF L +L SL + N + ++ + +S P L+ + +
Sbjct: 309 PDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTI-ESLPNLKEISIHS 367
Query: 478 NMWRCDC 484
N RCDC
Sbjct: 368 NPIRCDC 374
Score = 58.4 bits (135), Expect = 9e-08
Identities = 72/295 (24%), Positives = 135/295 (45%), Gaps = 20/295 (6%)
Query: 54 TDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALE 112
TD P + +T L++S N + ++ ++ L+++ + N+L LP+ L L+ L+
Sbjct: 88 TDFP----VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQ 143
Query: 113 VLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD 172
L ++ N + ++P + +L L L+ N+ Q + + L P+LE L++
Sbjct: 144 ELYINHNLLST---ISPG-AFIGLHNLLRLHLNSNRLQMINSKWFDAL---PNLEILMIG 196
Query: 173 HCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN--LIS-SSLRSLFVSNCELTSLNHNE 229
I I + LIN+R L + L I + L+ +L S+ + L + H
Sbjct: 197 ENPIIRIKDMN-FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
Query: 230 LMFLPSLTHLKMSNN--YRLELASSANNLFSQSLKYIDI-SYCNILQPNLKGFPSLRK-A 285
L + +L L ++ N R+ +N L + L ++ +I + P LRK
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
Query: 286 ILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
N+ + Y+ NAF +LE L L++N +++L + T L LK + + N I
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPI 370
Score = 44.4 bits (100), Expect = 0.002
Identities = 61/254 (24%), Positives = 119/254 (46%), Gaps = 23/254 (9%)
Query: 53 LTDIPNGLGLQVTKLN---ISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT++P +++ L I++N + P + LHNL+ L ++SN+L+ + L
Sbjct: 128 LTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDAL 187
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
LE+L + N ++N P +L+ L ++ + + + L+ +LE+
Sbjct: 188 PNLEILMIGENPIIRIKDMN----FKPLINLRSLVIA---GINLTEIPDNALVGLENLES 240
Query: 169 L-ILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSS---LRSLFVSNC-ELT 223
+ D+ I H L ++N++ L LN NP+ RI+ S+ L+ L ++N EL
Sbjct: 241 ISFYDNRLIKVPH--VALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELI 298
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS----QSLKYIDISYCNILQPNLKGF 279
S++ + LP L ++ +NN RL N F +SL + + ++
Sbjct: 299 SIDSLAVDNLPDLRKIEATNNPRLSYI-HPNAFFRLPKLESLMLNSNALSALYHGTIESL 357
Query: 280 PSLRKAILNHNMVR 293
P+L++ ++ N +R
Sbjct: 358 PNLKEISIHSNPIR 371
>AB060967-1|BAB47184.1| 708|Homo sapiens neuronal leucine-rich
repeat protein-3 protein.
Length = 708
Score = 80.2 bits (189), Expect = 2e-14
Identities = 74/307 (24%), Positives = 144/307 (46%), Gaps = 14/307 (4%)
Query: 190 NIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
N ++L L N + +I+ +L L +S L+S+ + + +P L + + N
Sbjct: 70 NTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129
Query: 248 ELASSA-NNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
EL + L + YI+ + + + P G +L + LN N ++ + S F
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPN 189
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N I ++ F+ L L+ L ++ + IP+++L+ + +L + N L
Sbjct: 190 LEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 366 RVGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP-DSISSNTL 421
+V H+ + +++ LD++ +N I + + + EL ++ N+ I DS++ + L
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGIN-NMPELISIDSLAVDNL 308
Query: 422 KYLN----LNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSD 477
L N R+S I+ FF L +L SL + N + ++ + +S P L+ + +
Sbjct: 309 PDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTI-ESLPNLKEISIHS 367
Query: 478 NMWRCDC 484
N RCDC
Sbjct: 368 NPIRCDC 374
Score = 58.4 bits (135), Expect = 9e-08
Identities = 72/295 (24%), Positives = 135/295 (45%), Gaps = 20/295 (6%)
Query: 54 TDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALE 112
TD P + +T L++S N + ++ ++ L+++ + N+L LP+ L L+ L+
Sbjct: 88 TDFP----VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQ 143
Query: 113 VLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD 172
L ++ N + ++P + +L L L+ N+ Q + + L P+LE L++
Sbjct: 144 ELYINHNLLST---ISPG-AFIGLHNLLRLHLNSNRLQMINSKWFDAL---PNLEILMIG 196
Query: 173 HCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN--LIS-SSLRSLFVSNCELTSLNHNE 229
I I + LIN+R L + L I + L+ +L S+ + L + H
Sbjct: 197 ENPIIRIKDMN-FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVA 255
Query: 230 LMFLPSLTHLKMSNN--YRLELASSANNLFSQSLKYIDI-SYCNILQPNLKGFPSLRK-A 285
L + +L L ++ N R+ +N L + L ++ +I + P LRK
Sbjct: 256 LQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIE 315
Query: 286 ILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
N+ + Y+ NAF +LE L L++N +++L + T L LK + + N I
Sbjct: 316 ATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPI 370
Score = 44.4 bits (100), Expect = 0.002
Identities = 61/254 (24%), Positives = 119/254 (46%), Gaps = 23/254 (9%)
Query: 53 LTDIPNGLGLQVTKLN---ISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT++P +++ L I++N + P + LHNL+ L ++SN+L+ + L
Sbjct: 128 LTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDAL 187
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLET 168
LE+L + N ++N P +L+ L ++ + + + L+ +LE+
Sbjct: 188 PNLEILMIGENPIIRIKDMN----FKPLINLRSLVIA---GINLTEIPDNALVGLENLES 240
Query: 169 L-ILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSS---LRSLFVSNC-ELT 223
+ D+ I H L ++N++ L LN NP+ RI+ S+ L+ L ++N EL
Sbjct: 241 ISFYDNRLIKVPH--VALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELI 298
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS----QSLKYIDISYCNILQPNLKGF 279
S++ + LP L ++ +NN RL N F +SL + + ++
Sbjct: 299 SIDSLAVDNLPDLRKIEATNNPRLSYI-HPNAFFRLPKLESLMLNSNALSALYHGTIESL 357
Query: 280 PSLRKAILNHNMVR 293
P+L++ ++ N +R
Sbjct: 358 PNLKEISIHSNPIR 371
>BC073974-1|AAH73974.1| 359|Homo sapiens chondroadherin protein.
Length = 359
Score = 79.4 bits (187), Expect = 4e-14
Identities = 72/268 (26%), Positives = 122/268 (45%), Gaps = 14/268 (5%)
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNA 299
NN+ + A+S + +L + + +C I + F L++ I L+HN +R L + A
Sbjct: 61 NNFPVLAANSFRAM--PNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGA 118
Query: 300 FANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKL 359
F + TEL YL L +N + L L L L L+ N+I + + L L L
Sbjct: 119 FDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYL 178
Query: 360 SRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI 416
S N LS + G L + ++ + +L++ +L L+ + EL LS N L IPD+
Sbjct: 179 SENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNA 238
Query: 417 SSNTLKYLN---LNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERL 473
+ +YL L+ + ++ F + L + + NR + FDS LE L
Sbjct: 239 FQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDS---LETL 295
Query: 474 DLSDNMWRCDCSDENMRDFYDFVTLEPN 501
L++N W+C C +R + + P+
Sbjct: 296 ALTNNPWKCTCQLRGLRRWLEAKASRPD 323
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/285 (25%), Positives = 120/285 (42%), Gaps = 18/285 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ D + C + GL IP + + LN+ N F S + NLV+L +
Sbjct: 27 CHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHC 85
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
Q++ + A L L L LS N L D L T L L L NK +
Sbjct: 86 QIREVAAGAFRGLKQLIYLYLSHNDI-RVLRAGAFDDL---TELTYLYLDHNKVTELPRG 141
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
L+ +L L L++ +I + G ++R L L+ N L +Q + +L
Sbjct: 142 LLSPLV---NLFILQLNNNKIRELRA-GAFQGAKDLRWLYLSENALSSLQPGALDDVENL 197
Query: 216 ---FVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL 272
V +L+S L L + LK+S+N + +A F + L+ + + N+
Sbjct: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLE 257
Query: 273 QPN---LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+ + G +L+ L +N + L SN F ++ LE L L+NN
Sbjct: 258 KFSDGAFLGVTTLKHVHLENNRLNQLPSN-FPFDS-LETLALTNN 300
Score = 46.4 bits (105), Expect = 4e-04
Identities = 68/254 (26%), Positives = 109/254 (42%), Gaps = 38/254 (14%)
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
K+L+L N F LA P+L +L L HC+I + GL + L L+ N
Sbjct: 54 KLLNLQRNNFPV---LAANSFRAMPNLVSLHLQHCQIREV-AAGAFRGLKQLIYLYLSHN 109
Query: 200 PL--LRIQNLIS-SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNL 256
+ LR + L L++ + ++T L L L +L L+++NN EL + A
Sbjct: 110 DIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQ- 168
Query: 257 FSQSLKYIDISY--CNILQPN-----------------LKGFPS--------LRKAILNH 289
++ L+++ +S + LQP L +PS + + L+H
Sbjct: 169 GAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSH 228
Query: 290 NMVRYLESNAFAN-NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
N ++ + NAF + LE L L N N+ F G+ LKH+ L N + +P S
Sbjct: 229 NPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLP--SN 286
Query: 349 LEMPSLTQLKLSRN 362
SL L L+ N
Sbjct: 287 FPFDSLETLALTNN 300
>BC036360-1|AAH36360.1| 359|Homo sapiens chondroadherin protein.
Length = 359
Score = 79.4 bits (187), Expect = 4e-14
Identities = 72/268 (26%), Positives = 122/268 (45%), Gaps = 14/268 (5%)
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNA 299
NN+ + A+S + +L + + +C I + F L++ I L+HN +R L + A
Sbjct: 61 NNFPVLAANSFRAM--PNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGA 118
Query: 300 FANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKL 359
F + TEL YL L +N + L L L L L+ N+I + + L L L
Sbjct: 119 FDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYL 178
Query: 360 SRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI 416
S N LS + G L + ++ + +L++ +L L+ + EL LS N L IPD+
Sbjct: 179 SENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNA 238
Query: 417 SSNTLKYLN---LNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERL 473
+ +YL L+ + ++ F + L + + NR + FDS LE L
Sbjct: 239 FQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDS---LETL 295
Query: 474 DLSDNMWRCDCSDENMRDFYDFVTLEPN 501
L++N W+C C +R + + P+
Sbjct: 296 ALTNNPWKCTCQLRGLRRWLEAKASRPD 323
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/285 (25%), Positives = 120/285 (42%), Gaps = 18/285 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ D + C + GL IP + + LN+ N F S + NLV+L +
Sbjct: 27 CHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHC 85
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
Q++ + A L L L LS N L D L T L L L NK +
Sbjct: 86 QIREVAAGAFRGLKQLIYLYLSHNDI-RVLRAGAFDDL---TELTYLYLDHNKVTELPRG 141
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
L+ +L L L++ +I + G ++R L L+ N L +Q + +L
Sbjct: 142 LLSPLV---NLFILQLNNNKIRELRA-GAFQGAKDLRWLYLSENALSSLQPGALDDVENL 197
Query: 216 ---FVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL 272
V +L+S L L + LK+S+N + +A F + L+ + + N+
Sbjct: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLE 257
Query: 273 QPN---LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+ + G +L+ L +N + L SN F ++ LE L L+NN
Sbjct: 258 KFSDGAFLGVTTLKHVHLENNRLNQLPSN-FPFDS-LETLALTNN 300
Score = 46.4 bits (105), Expect = 4e-04
Identities = 68/254 (26%), Positives = 109/254 (42%), Gaps = 38/254 (14%)
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
K+L+L N F LA P+L +L L HC+I + GL + L L+ N
Sbjct: 54 KLLNLQRNNFPV---LAANSFRAMPNLVSLHLQHCQIREV-AAGAFRGLKQLIYLYLSHN 109
Query: 200 PL--LRIQNLIS-SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNL 256
+ LR + L L++ + ++T L L L +L L+++NN EL + A
Sbjct: 110 DIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQ- 168
Query: 257 FSQSLKYIDISY--CNILQPN-----------------LKGFPS--------LRKAILNH 289
++ L+++ +S + LQP L +PS + + L+H
Sbjct: 169 GAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSH 228
Query: 290 NMVRYLESNAFAN-NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
N ++ + NAF + LE L L N N+ F G+ LKH+ L N + +P S
Sbjct: 229 NPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLP--SN 286
Query: 349 LEMPSLTQLKLSRN 362
SL L L+ N
Sbjct: 287 FPFDSLETLALTNN 300
>AF371328-1|AAK51556.1| 359|Homo sapiens chondroadherin protein.
Length = 359
Score = 79.4 bits (187), Expect = 4e-14
Identities = 72/268 (26%), Positives = 122/268 (45%), Gaps = 14/268 (5%)
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNA 299
NN+ + A+S + +L + + +C I + F L++ I L+HN +R L + A
Sbjct: 61 NNFPVLAANSFRAM--PNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGA 118
Query: 300 FANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKL 359
F + TEL YL L +N + L L L L L+ N+I + + L L L
Sbjct: 119 FDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYL 178
Query: 360 SRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI 416
S N LS + G L + ++ + +L++ +L L+ + EL LS N L IPD+
Sbjct: 179 SENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNA 238
Query: 417 SSNTLKYLN---LNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERL 473
+ +YL L+ + ++ F + L + + NR + FDS LE L
Sbjct: 239 FQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDS---LETL 295
Query: 474 DLSDNMWRCDCSDENMRDFYDFVTLEPN 501
L++N W+C C +R + + P+
Sbjct: 296 ALTNNPWKCTCQLRGLRRWLEAKASRPD 323
Score = 48.8 bits (111), Expect = 7e-05
Identities = 74/285 (25%), Positives = 120/285 (42%), Gaps = 18/285 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ D + C + GL IP + + LN+ N F S + NLV+L +
Sbjct: 27 CHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHC 85
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
Q++ + A L L L LS N L D L T L L L NK +
Sbjct: 86 QIREVAAGAFRGLKQLIYLYLSHNDI-RVLRAGAFDDL---TELTYLYLDHNKVTELPRG 141
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
L+ +L L L++ +I + G ++R L L+ N L +Q + +L
Sbjct: 142 LLSPLV---NLFILQLNNNKIRELRA-GAFQGAKDLRWLYLSENALSSLQPGALDDVENL 197
Query: 216 ---FVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL 272
V +L+S L L + LK+S+N + +A F + L+ + + N+
Sbjct: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLE 257
Query: 273 QPN---LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+ + G +L+ L +N + L SN F ++ LE L L+NN
Sbjct: 258 KFSDGAFLGVTTLKHVHLENNRLNQLPSN-FPFDS-LETLALTNN 300
Score = 46.4 bits (105), Expect = 4e-04
Identities = 68/254 (26%), Positives = 109/254 (42%), Gaps = 38/254 (14%)
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
K+L+L N F LA P+L +L L HC+I + GL + L L+ N
Sbjct: 54 KLLNLQRNNFPV---LAANSFRAMPNLVSLHLQHCQIREV-AAGAFRGLKQLIYLYLSHN 109
Query: 200 PL--LRIQNLIS-SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNL 256
+ LR + L L++ + ++T L L L +L L+++NN EL + A
Sbjct: 110 DIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQ- 168
Query: 257 FSQSLKYIDISY--CNILQPN-----------------LKGFPS--------LRKAILNH 289
++ L+++ +S + LQP L +PS + + L+H
Sbjct: 169 GAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSH 228
Query: 290 NMVRYLESNAFAN-NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
N ++ + NAF + LE L L N N+ F G+ LKH+ L N + +P S
Sbjct: 229 NPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLP--SN 286
Query: 349 LEMPSLTQLKLSRN 362
SL L L+ N
Sbjct: 287 FPFDSLETLALTNN 300
>BC117370-1|AAI17371.1| 1065|Homo sapiens leucine-rich repeats and
immunoglobulin-like domains 2 protein.
Length = 1065
Score = 79.0 bits (186), Expect = 6e-14
Identities = 87/310 (28%), Positives = 154/310 (49%), Gaps = 25/310 (8%)
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-------SLT 237
LSGL+ L+F+ N +S+ SL + +N+NEL +P ++T
Sbjct: 69 LSGLLPPDTAILDFS-----HNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNIT 123
Query: 238 HLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN--HNMVRYL 295
L + +N E+ + A F +L+ +D+S I + FP ++ LN +N + L
Sbjct: 124 LLSLVHNIIPEINAQALQ-FYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTL 182
Query: 296 ESNAFAN-NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
E+ F N ++ L + L+ N ++ + F+ L L+ L+L N I ++ + + SL
Sbjct: 183 EAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSL 241
Query: 355 TQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSY 411
LK+ RN +S++ G + ++ L++ L + K L GL+ + +L +SQN +
Sbjct: 242 RSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIER 301
Query: 412 I-PDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSF-FDSNP 468
I PD+ L L+L+YN+++ ++ F L+ L L++ NR T I F F SN
Sbjct: 302 ISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN- 360
Query: 469 YLERLDLSDN 478
L+ LDL +N
Sbjct: 361 -LQTLDLRNN 369
Score = 74.5 bits (175), Expect = 1e-12
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 15/246 (6%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SLR + N + L+ AF +E L+L +NN+ + GL+ML+ L +S
Sbjct: 236 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVS 295
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD---MSSCELNTIGKDSL 393
N I I D+ L++L LS N L+R+ + +++L+ + + I
Sbjct: 296 QNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVF 355
Query: 394 EGLQSIVELDLSQNLLSYIPDSISS-----NTLKYLNLNYNRISSINNLTFFMLNRLTSL 448
L ++ LDL N +S+ + S +L L L N+I SI F L L L
Sbjct: 356 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHL 415
Query: 449 SVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFN 508
+ N I +F S +L+ L L+ + CDC + + + L N + S N
Sbjct: 416 DLNNNAIMSIQENAF--SQTHLKELILNTSSLLCDCHLKWLLQW-----LVDNNFQHSVN 468
Query: 509 LICNSP 514
+ C P
Sbjct: 469 VSCAHP 474
Score = 69.7 bits (163), Expect = 3e-11
Identities = 89/336 (26%), Positives = 142/336 (42%), Gaps = 39/336 (11%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF 121
LQ K+N NE T+ P N+ L + N + + AL ALE L+LS N
Sbjct: 99 LQEVKMNY--NELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
Query: 122 DSWLNLNPNDVLLPATHLKILDLSFNKFQTM-----GNLANQELLIR------------- 163
+ P LK L+LS N+ T+ NL++ L+++
Sbjct: 157 SEIKTSS-----FPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKI 211
Query: 164 ---PSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFV 217
P L+ L L I + G + GL ++R LK+ N + ++++ +++ L +
Sbjct: 212 FKLPHLQFLELKRNRIKIVEGLT-FQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELEL 270
Query: 218 SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL---QP 274
+ LT +N L L L L +S N +E S F Q L +D+SY + +
Sbjct: 271 EHNNLTRVNKGWLYGLRMLQQLYVSQN-AIERISPDAWEFCQRLSELDLSYNQLTRLDES 329
Query: 275 NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD---TFRGLKMLK 331
G L + L N V ++ F + L+ LDL NN I+ D F GL L
Sbjct: 330 AFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLT 389
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L N+I I + + + + SL L L+ N + +
Sbjct: 390 KLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSI 425
Score = 51.6 bits (118), Expect = 1e-05
Identities = 69/259 (26%), Positives = 117/259 (45%), Gaps = 22/259 (8%)
Query: 45 DIDCSRRGLTDIPNG--LGLQVTK-LNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGL 100
+++ LT + G GL++ + L +S N + P++ L LD+S NQL L
Sbjct: 267 ELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRL 326
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
++A L+ LE LNL D+ + + V ++L+ LDL N+ A++
Sbjct: 327 DESAFVGLSLLERLNLG----DNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAF 382
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ-NLISSS-LRSLFVS 218
SL LIL +I SI + GL ++ L LN N ++ IQ N S + L+ L ++
Sbjct: 383 AGLTSLTKLILQGNQIKSI-TKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILN 441
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANN---LFSQSLKYIDIS--YC-NIL 272
L H L L + NN++ + S + L QS+ +D+ C + L
Sbjct: 442 TSSLLCDCH-----LKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFL 496
Query: 273 QPNLKGFPSLRKAILNHNM 291
+P ++ P A+ N+
Sbjct: 497 KPQIRTHPETIIALRGMNV 515
>BC117368-1|AAI17369.1| 1065|Homo sapiens leucine-rich repeats and
immunoglobulin-like domains 2 protein.
Length = 1065
Score = 79.0 bits (186), Expect = 6e-14
Identities = 87/310 (28%), Positives = 154/310 (49%), Gaps = 25/310 (8%)
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-------SLT 237
LSGL+ L+F+ N +S+ SL + +N+NEL +P ++T
Sbjct: 69 LSGLLPPDTAILDFS-----HNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNIT 123
Query: 238 HLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN--HNMVRYL 295
L + +N E+ + A F +L+ +D+S I + FP ++ LN +N + L
Sbjct: 124 LLSLVHNIIPEINAQALQ-FYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTL 182
Query: 296 ESNAFAN-NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
E+ F N ++ L + L+ N ++ + F+ L L+ L+L N I ++ + + SL
Sbjct: 183 EAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSL 241
Query: 355 TQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSY 411
LK+ RN +S++ G + ++ L++ L + K L GL+ + +L +SQN +
Sbjct: 242 RSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIER 301
Query: 412 I-PDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSF-FDSNP 468
I PD+ L L+L+YN+++ ++ F L+ L L++ NR T I F F SN
Sbjct: 302 ISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN- 360
Query: 469 YLERLDLSDN 478
L+ LDL +N
Sbjct: 361 -LQTLDLRNN 369
Score = 74.5 bits (175), Expect = 1e-12
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 15/246 (6%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SLR + N + L+ AF +E L+L +NN+ + GL+ML+ L +S
Sbjct: 236 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVS 295
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD---MSSCELNTIGKDSL 393
N I I D+ L++L LS N L+R+ + +++L+ + + I
Sbjct: 296 QNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVF 355
Query: 394 EGLQSIVELDLSQNLLSYIPDSISS-----NTLKYLNLNYNRISSINNLTFFMLNRLTSL 448
L ++ LDL N +S+ + S +L L L N+I SI F L L L
Sbjct: 356 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHL 415
Query: 449 SVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFN 508
+ N I +F S +L+ L L+ + CDC + + + L N + S N
Sbjct: 416 DLNNNAIMSIQENAF--SQTHLKELILNTSSLLCDCHLKWLLQW-----LVDNNFQHSVN 468
Query: 509 LICNSP 514
+ C P
Sbjct: 469 VSCAHP 474
Score = 69.7 bits (163), Expect = 3e-11
Identities = 89/336 (26%), Positives = 142/336 (42%), Gaps = 39/336 (11%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF 121
LQ K+N NE T+ P N+ L + N + + AL ALE L+LS N
Sbjct: 99 LQEVKMNY--NELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
Query: 122 DSWLNLNPNDVLLPATHLKILDLSFNKFQTM-----GNLANQELLIR------------- 163
+ P LK L+LS N+ T+ NL++ L+++
Sbjct: 157 SEIKTSS-----FPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKI 211
Query: 164 ---PSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFV 217
P L+ L L I + G + GL ++R LK+ N + ++++ +++ L +
Sbjct: 212 FKLPHLQFLELKRNRIKIVEGLT-FQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELEL 270
Query: 218 SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL---QP 274
+ LT +N L L L L +S N +E S F Q L +D+SY + +
Sbjct: 271 EHNNLTRVNKGWLYGLRMLQQLYVSQN-AIERISPDAWEFCQRLSELDLSYNQLTRLDES 329
Query: 275 NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD---TFRGLKMLK 331
G L + L N V ++ F + L+ LDL NN I+ D F GL L
Sbjct: 330 AFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLT 389
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L N+I I + + + + SL L L+ N + +
Sbjct: 390 KLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSI 425
Score = 51.6 bits (118), Expect = 1e-05
Identities = 69/259 (26%), Positives = 117/259 (45%), Gaps = 22/259 (8%)
Query: 45 DIDCSRRGLTDIPNG--LGLQVTK-LNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGL 100
+++ LT + G GL++ + L +S N + P++ L LD+S NQL L
Sbjct: 267 ELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRL 326
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
++A L+ LE LNL D+ + + V ++L+ LDL N+ A++
Sbjct: 327 DESAFVGLSLLERLNLG----DNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAF 382
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ-NLISSS-LRSLFVS 218
SL LIL +I SI + GL ++ L LN N ++ IQ N S + L+ L ++
Sbjct: 383 AGLTSLTKLILQGNQIKSI-TKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILN 441
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANN---LFSQSLKYIDIS--YC-NIL 272
L H L L + NN++ + S + L QS+ +D+ C + L
Sbjct: 442 TSSLLCDCH-----LKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFL 496
Query: 273 QPNLKGFPSLRKAILNHNM 291
+P ++ P A+ N+
Sbjct: 497 KPQIRTHPETIIALRGMNV 515
>AL357055-1|CAH73254.1| 1065|Homo sapiens leucine-rich repeats and
immunoglobulin-like domains 2 protein.
Length = 1065
Score = 79.0 bits (186), Expect = 6e-14
Identities = 87/310 (28%), Positives = 154/310 (49%), Gaps = 25/310 (8%)
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-------SLT 237
LSGL+ L+F+ N +S+ SL + +N+NEL +P ++T
Sbjct: 69 LSGLLPPDTAILDFS-----HNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNIT 123
Query: 238 HLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN--HNMVRYL 295
L + +N E+ + A F +L+ +D+S I + FP ++ LN +N + L
Sbjct: 124 LLSLVHNIIPEINAQALQ-FYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTL 182
Query: 296 ESNAFAN-NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
E+ F N ++ L + L+ N ++ + F+ L L+ L+L N I ++ + + SL
Sbjct: 183 EAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSL 241
Query: 355 TQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSY 411
LK+ RN +S++ G + ++ L++ L + K L GL+ + +L +SQN +
Sbjct: 242 RSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIER 301
Query: 412 I-PDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSF-FDSNP 468
I PD+ L L+L+YN+++ ++ F L+ L L++ NR T I F F SN
Sbjct: 302 ISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN- 360
Query: 469 YLERLDLSDN 478
L+ LDL +N
Sbjct: 361 -LQTLDLRNN 369
Score = 74.5 bits (175), Expect = 1e-12
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 15/246 (6%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SLR + N + L+ AF +E L+L +NN+ + GL+ML+ L +S
Sbjct: 236 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVS 295
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD---MSSCELNTIGKDSL 393
N I I D+ L++L LS N L+R+ + +++L+ + + I
Sbjct: 296 QNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVF 355
Query: 394 EGLQSIVELDLSQNLLSYIPDSISS-----NTLKYLNLNYNRISSINNLTFFMLNRLTSL 448
L ++ LDL N +S+ + S +L L L N+I SI F L L L
Sbjct: 356 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHL 415
Query: 449 SVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFN 508
+ N I +F S +L+ L L+ + CDC + + + L N + S N
Sbjct: 416 DLNNNAIMSIQENAF--SQTHLKELILNTSSLLCDCHLKWLLQW-----LVDNNFQHSVN 468
Query: 509 LICNSP 514
+ C P
Sbjct: 469 VSCAHP 474
Score = 69.7 bits (163), Expect = 3e-11
Identities = 89/336 (26%), Positives = 142/336 (42%), Gaps = 39/336 (11%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF 121
LQ K+N NE T+ P N+ L + N + + AL ALE L+LS N
Sbjct: 99 LQEVKMNY--NELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
Query: 122 DSWLNLNPNDVLLPATHLKILDLSFNKFQTM-----GNLANQELLIR------------- 163
+ P LK L+LS N+ T+ NL++ L+++
Sbjct: 157 SEIKTSS-----FPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKI 211
Query: 164 ---PSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFV 217
P L+ L L I + G + GL ++R LK+ N + ++++ +++ L +
Sbjct: 212 FKLPHLQFLELKRNRIKIVEGLT-FQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELEL 270
Query: 218 SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL---QP 274
+ LT +N L L L L +S N +E S F Q L +D+SY + +
Sbjct: 271 EHNNLTRVNKGWLYGLRMLQQLYVSQN-AIERISPDAWEFCQRLSELDLSYNQLTRLDES 329
Query: 275 NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD---TFRGLKMLK 331
G L + L N V ++ F + L+ LDL NN I+ D F GL L
Sbjct: 330 AFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLT 389
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L N+I I + + + + SL L L+ N + +
Sbjct: 390 KLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSI 425
Score = 51.6 bits (118), Expect = 1e-05
Identities = 69/259 (26%), Positives = 117/259 (45%), Gaps = 22/259 (8%)
Query: 45 DIDCSRRGLTDIPNG--LGLQVTK-LNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGL 100
+++ LT + G GL++ + L +S N + P++ L LD+S NQL L
Sbjct: 267 ELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRL 326
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
++A L+ LE LNL D+ + + V ++L+ LDL N+ A++
Sbjct: 327 DESAFVGLSLLERLNLG----DNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAF 382
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ-NLISSS-LRSLFVS 218
SL LIL +I SI + GL ++ L LN N ++ IQ N S + L+ L ++
Sbjct: 383 AGLTSLTKLILQGNQIKSI-TKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILN 441
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANN---LFSQSLKYIDIS--YC-NIL 272
L H L L + NN++ + S + L QS+ +D+ C + L
Sbjct: 442 TSSLLCDCH-----LKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFL 496
Query: 273 QPNLKGFPSLRKAILNHNM 291
+P ++ P A+ N+
Sbjct: 497 KPQIRTHPETIIALRGMNV 515
>AB018349-1|BAA34526.2| 1073|Homo sapiens KIAA0806 protein protein.
Length = 1073
Score = 79.0 bits (186), Expect = 6e-14
Identities = 87/310 (28%), Positives = 154/310 (49%), Gaps = 25/310 (8%)
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLP-------SLT 237
LSGL+ L+F+ N +S+ SL + +N+NEL +P ++T
Sbjct: 77 LSGLLPPDTAILDFS-----HNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNIT 131
Query: 238 HLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN--HNMVRYL 295
L + +N E+ + A F +L+ +D+S I + FP ++ LN +N + L
Sbjct: 132 LLSLVHNIIPEINAQALQ-FYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTL 190
Query: 296 ESNAFAN-NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
E+ F N ++ L + L+ N ++ + F+ L L+ L+L N I ++ + + SL
Sbjct: 191 EAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSL 249
Query: 355 TQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSY 411
LK+ RN +S++ G + ++ L++ L + K L GL+ + +L +SQN +
Sbjct: 250 RSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIER 309
Query: 412 I-PDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSF-FDSNP 468
I PD+ L L+L+YN+++ ++ F L+ L L++ NR T I F F SN
Sbjct: 310 ISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN- 368
Query: 469 YLERLDLSDN 478
L+ LDL +N
Sbjct: 369 -LQTLDLRNN 377
Score = 74.5 bits (175), Expect = 1e-12
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 15/246 (6%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SLR + N + L+ AF +E L+L +NN+ + GL+ML+ L +S
Sbjct: 244 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVS 303
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD---MSSCELNTIGKDSL 393
N I I D+ L++L LS N L+R+ + +++L+ + + I
Sbjct: 304 QNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVF 363
Query: 394 EGLQSIVELDLSQNLLSYIPDSISS-----NTLKYLNLNYNRISSINNLTFFMLNRLTSL 448
L ++ LDL N +S+ + S +L L L N+I SI F L L L
Sbjct: 364 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHL 423
Query: 449 SVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFN 508
+ N I +F S +L+ L L+ + CDC + + + L N + S N
Sbjct: 424 DLNNNAIMSIQENAF--SQTHLKELILNTSSLLCDCHLKWLLQW-----LVDNNFQHSVN 476
Query: 509 LICNSP 514
+ C P
Sbjct: 477 VSCAHP 482
Score = 69.7 bits (163), Expect = 3e-11
Identities = 89/336 (26%), Positives = 142/336 (42%), Gaps = 39/336 (11%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF 121
LQ K+N NE T+ P N+ L + N + + AL ALE L+LS N
Sbjct: 107 LQEVKMNY--NELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 164
Query: 122 DSWLNLNPNDVLLPATHLKILDLSFNKFQTM-----GNLANQELLIR------------- 163
+ P LK L+LS N+ T+ NL++ L+++
Sbjct: 165 SEIKTSS-----FPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKI 219
Query: 164 ---PSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFV 217
P L+ L L I + G + GL ++R LK+ N + ++++ +++ L +
Sbjct: 220 FKLPHLQFLELKRNRIKIVEGLT-FQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELEL 278
Query: 218 SNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL---QP 274
+ LT +N L L L L +S N +E S F Q L +D+SY + +
Sbjct: 279 EHNNLTRVNKGWLYGLRMLQQLYVSQN-AIERISPDAWEFCQRLSELDLSYNQLTRLDES 337
Query: 275 NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD---TFRGLKMLK 331
G L + L N V ++ F + L+ LDL NN I+ D F GL L
Sbjct: 338 AFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLT 397
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L N+I I + + + + SL L L+ N + +
Sbjct: 398 KLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSI 433
Score = 51.6 bits (118), Expect = 1e-05
Identities = 69/259 (26%), Positives = 117/259 (45%), Gaps = 22/259 (8%)
Query: 45 DIDCSRRGLTDIPNG--LGLQVTK-LNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGL 100
+++ LT + G GL++ + L +S N + P++ L LD+S NQL L
Sbjct: 275 ELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRL 334
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
++A L+ LE LNL D+ + + V ++L+ LDL N+ A++
Sbjct: 335 DESAFVGLSLLERLNLG----DNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAF 390
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ-NLISSS-LRSLFVS 218
SL LIL +I SI + GL ++ L LN N ++ IQ N S + L+ L ++
Sbjct: 391 AGLTSLTKLILQGNQIKSI-TKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILN 449
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANN---LFSQSLKYIDIS--YC-NIL 272
L H L L + NN++ + S + L QS+ +D+ C + L
Sbjct: 450 TSSLLCDCH-----LKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFL 504
Query: 273 QPNLKGFPSLRKAILNHNM 291
+P ++ P A+ N+
Sbjct: 505 KPQIRTHPETIIALRGMNV 523
>BC033651-1|AAH33651.1| 1049|Homo sapiens toll-like receptor 7
protein.
Length = 1049
Score = 78.2 bits (184), Expect = 1e-13
Identities = 114/412 (27%), Positives = 182/412 (44%), Gaps = 51/412 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNA 104
+DC+ + LT+IP G+ T L ++ N P S RL +LV +D N + +P +
Sbjct: 49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP-IPLGS 107
Query: 105 LYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRP 164
N+ ++ L + F T+LK L L N+ L + P
Sbjct: 108 KNNM-CIKRLQIKPRSFSG------------LTYLKSLYLDGNQ------LLEIPQGLPP 148
Query: 165 SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS---LFVSNCE 221
SL+ L L+ I SI + L+ L NI +L L N R +S S+ L ++ +
Sbjct: 149 SLQLLSLEANNIFSIR-KENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLK 207
Query: 222 LTSLNHNELMFLPS-----LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ SL N + +P+ LT L + NN ++ N +Q L+ +D+S N +
Sbjct: 208 VLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQ-LQILDLSG-NCPRCYN 265
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
FP A +N + NAF TEL+ L L +N++ + F+ + L+ LDLS
Sbjct: 266 APFPC---APCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLS 322
Query: 337 WNEIAVIPEDS--LLEMPSLTQLKLSRNYLSRV-----------GHLRSMSV-TILDMSS 382
N +A D+ L +PSL QL LS N+ +V L+S+ + I
Sbjct: 323 QNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVF 382
Query: 383 CELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRIS 432
EL + L LQ++ LDL N + S+ LK ++L+ N+IS
Sbjct: 383 KELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKIS 434
Score = 55.6 bits (128), Expect = 6e-07
Identities = 120/468 (25%), Positives = 194/468 (41%), Gaps = 63/468 (13%)
Query: 71 NNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNP 129
NN + P + L L L + SN L+ +P N+ L+ L+LS+N+ +
Sbjct: 275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK 334
Query: 130 NDVLLPATHLKILDLSFN----KFQTMGNLANQELLIRPSLETLILDHCEINSIHG--RS 183
LP+ L LDLSFN ++ NL+ Q SL+ L + + S
Sbjct: 335 FLHFLPS--LIQLDLSFNFELQVYRASMNLS-QAFSSLKSLKILRIRGYVFKELKSFNLS 391
Query: 184 PLSGLINIRVLKLNFNPLLRIQNL------------------ISSSLRSLFVSNCE--LT 223
PL L N+ VL L N ++I NL IS S S V C T
Sbjct: 392 PLHNLQNLEVLDLGTN-FIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNART 450
Query: 224 SLNHNELMFLPSLTHL---KMSNNYRLELASSANNLFSQSL-KY---IDISYCNILQPNL 276
S+ E L L + K + + R + ++ ++S KY +D+S +I
Sbjct: 451 SVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKS 510
Query: 277 KGFPSLR--KAI-LNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
F L K + L+ N++ + L + F EL YLD SNN + L F L L+
Sbjct: 511 SDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEV 570
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQ-LKLSRNYL--------SRVGHLRSMSVTILDMSSC 383
LD+S N + + M + T+ LK+ + + S + S S+ L+
Sbjct: 571 LDISSNS-HYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGN 629
Query: 384 ELNTIGKDS-------LEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISS 433
L+ + ++ + L + ELD+S+N LS++P + LK L+L N + S
Sbjct: 630 HLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKS 689
Query: 434 INNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWR 481
+ L L +L + N+ T + R + + L+ L L +N R
Sbjct: 690 FSWKKLQCLKNLETLDLSHNQLTTVPER-LSNCSRSLKNLILKNNQIR 736
Score = 54.8 bits (126), Expect = 1e-06
Identities = 74/271 (27%), Positives = 120/271 (44%), Gaps = 27/271 (9%)
Query: 210 SSLRSLFVS-NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
S L+ L +S N +LN +E L L +L SNN RL+L S L+ +DIS
Sbjct: 517 SFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNN-RLDLLHSTAFEELHKLEVLDISS 575
Query: 269 -CNILQPN--------LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
+ Q K L+K ++N N + S + + L L+ N++ L
Sbjct: 576 NSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESES-LRTLEFRGNHLDVL 634
Query: 320 ------RY-DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRNYLSRVGHLR 371
RY F+ L L+ LD+S N ++ +P MP +L L L++N L +
Sbjct: 635 WREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKK 694
Query: 372 SM---SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNL 426
++ LD+S +L T+ + +S+ L L N + + + L+YL+L
Sbjct: 695 LQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDL 754
Query: 427 NYNRISSINNLTF--FMLNRLTSLSVVGNRF 455
+ N+I I +F +LN L L + NRF
Sbjct: 755 SSNKIQMIQKTSFPENVLNNLKMLLLHHNRF 785
Score = 51.2 bits (117), Expect = 1e-05
Identities = 87/338 (25%), Positives = 144/338 (42%), Gaps = 28/338 (8%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + + +L+ L+ LNLS N LN P L+ LD S N+
Sbjct: 498 LDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLN---GSEFQPLAELRYLDFSNNRL 554
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRI--Q 205
+ + A +EL L+ H + I H + L ++ L +N N + +
Sbjct: 555 DLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSR 614
Query: 206 NLISSSLRSLFVSNCELTSL-----NHNELMF--LPSLTHLKMSNNYRLELASSANNLFS 258
+ S SLR+L L L N +F L L L +S N L S +
Sbjct: 615 TMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMP 674
Query: 259 QSLKYIDISYCNILQ---PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNN 315
+LK + ++ + L+ +L L+HN + + + L+ L L NN
Sbjct: 675 PNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQ 734
Query: 316 IASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLE--MPSLTQLKLSRN-YLSR------ 366
I SL + L++LDLS N+I +I + S E + +L L L N +L
Sbjct: 735 IRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWF 794
Query: 367 VGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDL 404
V + VTI +++ ++ +G + +G QS++ LDL
Sbjct: 795 VWWVNHTEVTIPYLAT-DVTCVGPGAHKG-QSVISLDL 830
>AY358292-1|AAQ88659.1| 1049|Homo sapiens TLR7 protein.
Length = 1049
Score = 78.2 bits (184), Expect = 1e-13
Identities = 114/412 (27%), Positives = 182/412 (44%), Gaps = 51/412 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNA 104
+DC+ + LT+IP G+ T L ++ N P S RL +LV +D N + +P +
Sbjct: 49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP-IPLGS 107
Query: 105 LYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRP 164
N+ ++ L + F T+LK L L N+ L + P
Sbjct: 108 KNNM-CIKRLQIKPRSFSG------------LTYLKSLYLDGNQ------LLEIPQGLPP 148
Query: 165 SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS---LFVSNCE 221
SL+ L L+ I SI + L+ L NI +L L N R +S S+ L ++ +
Sbjct: 149 SLQLLSLEANNIFSIR-KENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLK 207
Query: 222 LTSLNHNELMFLPS-----LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ SL N + +P+ LT L + NN ++ N +Q L+ +D+S N +
Sbjct: 208 VLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQ-LQILDLSG-NCPRCYN 265
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
FP A +N + NAF TEL+ L L +N++ + F+ + L+ LDLS
Sbjct: 266 APFPC---APCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLS 322
Query: 337 WNEIAVIPEDS--LLEMPSLTQLKLSRNYLSRV-----------GHLRSMSV-TILDMSS 382
N +A D+ L +PSL QL LS N+ +V L+S+ + I
Sbjct: 323 QNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVF 382
Query: 383 CELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRIS 432
EL + L LQ++ LDL N + S+ LK ++L+ N+IS
Sbjct: 383 KELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKIS 434
Score = 55.6 bits (128), Expect = 6e-07
Identities = 120/468 (25%), Positives = 194/468 (41%), Gaps = 63/468 (13%)
Query: 71 NNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNP 129
NN + P + L L L + SN L+ +P N+ L+ L+LS+N+ +
Sbjct: 275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK 334
Query: 130 NDVLLPATHLKILDLSFN----KFQTMGNLANQELLIRPSLETLILDHCEINSIHG--RS 183
LP+ L LDLSFN ++ NL+ Q SL+ L + + S
Sbjct: 335 FLHFLPS--LIQLDLSFNFELQVYRASMNLS-QAFSSLKSLKILRIRGYVFKELKSFNLS 391
Query: 184 PLSGLINIRVLKLNFNPLLRIQNL------------------ISSSLRSLFVSNCE--LT 223
PL L N+ VL L N ++I NL IS S S V C T
Sbjct: 392 PLHNLQNLEVLDLGTN-FIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNART 450
Query: 224 SLNHNELMFLPSLTHL---KMSNNYRLELASSANNLFSQSL-KY---IDISYCNILQPNL 276
S+ E L L + K + + R + ++ ++S KY +D+S +I
Sbjct: 451 SVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKS 510
Query: 277 KGFPSLR--KAI-LNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
F L K + L+ N++ + L + F EL YLD SNN + L F L L+
Sbjct: 511 SDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEV 570
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQ-LKLSRNYL--------SRVGHLRSMSVTILDMSSC 383
LD+S N + + M + T+ LK+ + + S + S S+ L+
Sbjct: 571 LDISSNS-HYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGN 629
Query: 384 ELNTIGKDS-------LEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISS 433
L+ + ++ + L + ELD+S+N LS++P + LK L+L N + S
Sbjct: 630 HLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKS 689
Query: 434 INNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWR 481
+ L L +L + N+ T + R + + L+ L L +N R
Sbjct: 690 FSWKKLQCLKNLETLDLSHNQLTTVPER-LSNCSRSLKNLILKNNQIR 736
Score = 54.8 bits (126), Expect = 1e-06
Identities = 74/271 (27%), Positives = 120/271 (44%), Gaps = 27/271 (9%)
Query: 210 SSLRSLFVS-NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
S L+ L +S N +LN +E L L +L SNN RL+L S L+ +DIS
Sbjct: 517 SFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNN-RLDLLHSTAFEELHKLEVLDISS 575
Query: 269 -CNILQPN--------LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
+ Q K L+K ++N N + S + + L L+ N++ L
Sbjct: 576 NSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESES-LRTLEFRGNHLDVL 634
Query: 320 ------RY-DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRNYLSRVGHLR 371
RY F+ L L+ LD+S N ++ +P MP +L L L++N L +
Sbjct: 635 WREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKK 694
Query: 372 SM---SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNL 426
++ LD+S +L T+ + +S+ L L N + + + L+YL+L
Sbjct: 695 LQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDL 754
Query: 427 NYNRISSINNLTF--FMLNRLTSLSVVGNRF 455
+ N+I I +F +LN L L + NRF
Sbjct: 755 SSNKIQMIQKTSFPENVLNNLKMLLLHHNRF 785
Score = 51.2 bits (117), Expect = 1e-05
Identities = 87/338 (25%), Positives = 144/338 (42%), Gaps = 28/338 (8%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + + +L+ L+ LNLS N LN P L+ LD S N+
Sbjct: 498 LDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLN---GSEFQPLAELRYLDFSNNRL 554
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRI--Q 205
+ + A +EL L+ H + I H + L ++ L +N N + +
Sbjct: 555 DLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSR 614
Query: 206 NLISSSLRSLFVSNCELTSL-----NHNELMF--LPSLTHLKMSNNYRLELASSANNLFS 258
+ S SLR+L L L N +F L L L +S N L S +
Sbjct: 615 TMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMP 674
Query: 259 QSLKYIDISYCNILQ---PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNN 315
+LK + ++ + L+ +L L+HN + + + L+ L L NN
Sbjct: 675 PNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQ 734
Query: 316 IASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLE--MPSLTQLKLSRN-YLSR------ 366
I SL + L++LDLS N+I +I + S E + +L L L N +L
Sbjct: 735 IRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWF 794
Query: 367 VGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDL 404
V + VTI +++ ++ +G + +G QS++ LDL
Sbjct: 795 VWWVNHTEVTIPYLAT-DVTCVGPGAHKG-QSVISLDL 830
>AF245702-1|AAF78035.1| 1049|Homo sapiens toll-like receptor 7
protein.
Length = 1049
Score = 78.2 bits (184), Expect = 1e-13
Identities = 114/412 (27%), Positives = 182/412 (44%), Gaps = 51/412 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNA 104
+DC+ + LT+IP G+ T L ++ N P S RL +LV +D N + +P +
Sbjct: 49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP-IPLGS 107
Query: 105 LYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRP 164
N+ ++ L + F T+LK L L N+ L + P
Sbjct: 108 KNNM-CIKRLQIKPRSFSG------------LTYLKSLYLDGNQ------LLEIPQGLPP 148
Query: 165 SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS---LFVSNCE 221
SL+ L L+ I SI + L+ L NI +L L N R +S S+ L ++ +
Sbjct: 149 SLQLLSLEANNIFSIR-KENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLK 207
Query: 222 LTSLNHNELMFLPS-----LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ SL N + +P+ LT L + NN ++ N +Q L+ +D+S N +
Sbjct: 208 VLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQ-LQILDLSG-NCPRCYN 265
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
FP A +N + NAF TEL+ L L +N++ + F+ + L+ LDLS
Sbjct: 266 APFPC---APCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLS 322
Query: 337 WNEIAVIPEDS--LLEMPSLTQLKLSRNYLSRV-----------GHLRSMSV-TILDMSS 382
N +A D+ L +PSL QL LS N+ +V L+S+ + I
Sbjct: 323 QNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVF 382
Query: 383 CELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRIS 432
EL + L LQ++ LDL N + S+ LK ++L+ N+IS
Sbjct: 383 KELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKIS 434
Score = 56.0 bits (129), Expect = 5e-07
Identities = 78/283 (27%), Positives = 123/283 (43%), Gaps = 18/283 (6%)
Query: 210 SSLRSLFVS-NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
S L+ L +S N +LN +E L L +L SNN RL+L S L+ +DIS
Sbjct: 517 SFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNN-RLDLLHSTAFEELHKLEVLDIS- 574
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
N +G + N +++ L N+ ++ SLR FRG
Sbjct: 575 SNSHYFQSEGITHMLNFTKNLKVLQKL----MMNDNDISSSTSRTMESESLRTLEFRG-- 628
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMSVTILDMSSCE-- 384
HLD+ W E + L +L +S+N LS + G M + ++S +
Sbjct: 629 --NHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNG 686
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSIS--SNTLKYLNLNYNRISSINNLTFFML 442
L + L+ L+++ LDLS N L+ +P+ +S S + K L L N+I S
Sbjct: 687 LKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSHKNLILKNNQIRSPTKYFLQDA 746
Query: 443 NRLTSLSVVGNRFTMIWRRSFFDS-NPYLERLDLSDNMWRCDC 484
+L L + N+ MI + SF ++ L+ L L N + C C
Sbjct: 747 FQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTC 789
Score = 54.4 bits (125), Expect = 1e-06
Identities = 115/448 (25%), Positives = 185/448 (41%), Gaps = 62/448 (13%)
Query: 71 NNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNP 129
NN + P + L L L + SN L+ +P N+ L+ L+LS+N+ +
Sbjct: 275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK 334
Query: 130 NDVLLPATHLKILDLSFN----KFQTMGNLANQELLIRPSLETLILDHCEINSIHG--RS 183
LP+ L LDLSFN ++ NL+ Q SL+ L + + S
Sbjct: 335 FLHFLPS--LIQLDLSFNFELQVYRASMNLS-QAFSSLKSLKILRIRGYVFKELKSFNLS 391
Query: 184 PLSGLINIRVLKLNFNPLLRIQNL------------------ISSSLRSLFVSNCE--LT 223
PL L N+ VL L N ++I NL IS S S V C T
Sbjct: 392 PLHNLQNLEVLDLGTN-FIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNART 450
Query: 224 SLNHNELMFLPSLTHL---KMSNNYRLELASSANNLFSQSL-KY---IDISYCNILQPNL 276
S+ E L L + K + + R + ++ ++S KY +D+S +I
Sbjct: 451 SVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKS 510
Query: 277 KGFPSLR--KAI-LNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
F L K + L+ N++ + L + F EL YLD SNN + L F L L+
Sbjct: 511 SDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEV 570
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQ-LKLSRNYL--------SRVGHLRSMSVTILDMSSC 383
LD+S N + + M + T+ LK+ + + S + S S+ L+
Sbjct: 571 LDISSNS-HYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGN 629
Query: 384 ELNTIGKDS-------LEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISS 433
L+ + ++ + L + ELD+S+N LS++P + LK L+L N + S
Sbjct: 630 HLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKS 689
Query: 434 INNLTFFMLNRLTSLSVVGNRFTMIWRR 461
+ L L +L + N+ T + R
Sbjct: 690 FSWKKLQCLKNLETLDLSHNQLTTVPER 717
Score = 33.1 bits (72), Expect = 3.7
Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 5/85 (5%)
Query: 67 LNISNNEFTKFPESLSRL-HNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
L++S+N+ T PE LS + NL + +NQ++ L + L L+LS N
Sbjct: 704 LDLSHNQLTTVPERLSNCSRSHKNLILKNNQIRSPTKYFLQDAFQLRYLDLSSNKIQMIQ 763
Query: 126 NLN-PNDVLLPATHLKILDLSFNKF 149
+ P +VL +LK+L L N+F
Sbjct: 764 KTSFPENVL---NNLKMLLLHHNRF 785
>AF240467-1|AAF60188.1| 1049|Homo sapiens toll-like receptor 7
protein.
Length = 1049
Score = 78.2 bits (184), Expect = 1e-13
Identities = 114/412 (27%), Positives = 182/412 (44%), Gaps = 51/412 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNA 104
+DC+ + LT+IP G+ T L ++ N P S RL +LV +D N + +P +
Sbjct: 49 VDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVP-IPLGS 107
Query: 105 LYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRP 164
N+ ++ L + F T+LK L L N+ L + P
Sbjct: 108 KNNM-CIKRLQIKPRSFSG------------LTYLKSLYLDGNQ------LLEIPQGLPP 148
Query: 165 SLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS---LFVSNCE 221
SL+ L L+ I SI + L+ L NI +L L N R +S S+ L ++ +
Sbjct: 149 SLQLLSLEANNIFSIR-KENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLK 207
Query: 222 LTSLNHNELMFLPS-----LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ SL N + +P+ LT L + NN ++ N +Q L+ +D+S N +
Sbjct: 208 VLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQ-LQILDLSG-NCPRCYN 265
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
FP A +N + NAF TEL+ L L +N++ + F+ + L+ LDLS
Sbjct: 266 APFPC---APCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLS 322
Query: 337 WNEIAVIPEDS--LLEMPSLTQLKLSRNYLSRV-----------GHLRSMSV-TILDMSS 382
N +A D+ L +PSL QL LS N+ +V L+S+ + I
Sbjct: 323 QNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVF 382
Query: 383 CELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRIS 432
EL + L LQ++ LDL N + S+ LK ++L+ N+IS
Sbjct: 383 KELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKIS 434
Score = 55.6 bits (128), Expect = 6e-07
Identities = 120/468 (25%), Positives = 194/468 (41%), Gaps = 63/468 (13%)
Query: 71 NNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNP 129
NN + P + L L L + SN L+ +P N+ L+ L+LS+N+ +
Sbjct: 275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK 334
Query: 130 NDVLLPATHLKILDLSFN----KFQTMGNLANQELLIRPSLETLILDHCEINSIHG--RS 183
LP+ L LDLSFN ++ NL+ Q SL+ L + + S
Sbjct: 335 FLHFLPS--LIQLDLSFNFELQVYRASMNLS-QAFSSLKSLKILRIRGYVFKELKSFNLS 391
Query: 184 PLSGLINIRVLKLNFNPLLRIQNL------------------ISSSLRSLFVSNCE--LT 223
PL L N+ VL L N ++I NL IS S S V C T
Sbjct: 392 PLHNLQNLEVLDLGTN-FIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNART 450
Query: 224 SLNHNELMFLPSLTHL---KMSNNYRLELASSANNLFSQSL-KY---IDISYCNILQPNL 276
S+ E L L + K + + R + ++ ++S KY +D+S +I
Sbjct: 451 SVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKS 510
Query: 277 KGFPSLR--KAI-LNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
F L K + L+ N++ + L + F EL YLD SNN + L F L L+
Sbjct: 511 SDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEV 570
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQ-LKLSRNYL--------SRVGHLRSMSVTILDMSSC 383
LD+S N + + M + T+ LK+ + + S + S S+ L+
Sbjct: 571 LDISSNS-HYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGN 629
Query: 384 ELNTIGKDS-------LEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISS 433
L+ + ++ + L + ELD+S+N LS++P + LK L+L N + S
Sbjct: 630 HLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKS 689
Query: 434 INNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWR 481
+ L L +L + N+ T + R + + L+ L L +N R
Sbjct: 690 FSWKKLQCLKNLETLDLSHNQLTTVPER-LSNCSRSLKNLILKNNQIR 736
Score = 54.8 bits (126), Expect = 1e-06
Identities = 74/271 (27%), Positives = 120/271 (44%), Gaps = 27/271 (9%)
Query: 210 SSLRSLFVS-NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
S L+ L +S N +LN +E L L +L SNN RL+L S L+ +DIS
Sbjct: 517 SFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNN-RLDLLHSTAFEELHKLEVLDISS 575
Query: 269 -CNILQPN--------LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
+ Q K L+K ++N N + S + + L L+ N++ L
Sbjct: 576 NSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESES-LRTLEFRGNHLDVL 634
Query: 320 ------RY-DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRNYLSRVGHLR 371
RY F+ L L+ LD+S N ++ +P MP +L L L++N L +
Sbjct: 635 WREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKK 694
Query: 372 SM---SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNL 426
++ LD+S +L T+ + +S+ L L N + + + L+YL+L
Sbjct: 695 LQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDL 754
Query: 427 NYNRISSINNLTF--FMLNRLTSLSVVGNRF 455
+ N+I I +F +LN L L + NRF
Sbjct: 755 SSNKIQMIQKTSFPENVLNNLKMLLLHHNRF 785
Score = 51.2 bits (117), Expect = 1e-05
Identities = 87/338 (25%), Positives = 144/338 (42%), Gaps = 28/338 (8%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + + +L+ L+ LNLS N LN P L+ LD S N+
Sbjct: 498 LDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLN---GSEFQPLAELRYLDFSNNRL 554
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRI--Q 205
+ + A +EL L+ H + I H + L ++ L +N N + +
Sbjct: 555 DLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSR 614
Query: 206 NLISSSLRSLFVSNCELTSL-----NHNELMF--LPSLTHLKMSNNYRLELASSANNLFS 258
+ S SLR+L L L N +F L L L +S N L S +
Sbjct: 615 TMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMP 674
Query: 259 QSLKYIDISYCNILQ---PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNN 315
+LK + ++ + L+ +L L+HN + + + L+ L L NN
Sbjct: 675 PNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQ 734
Query: 316 IASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLE--MPSLTQLKLSRN-YLSR------ 366
I SL + L++LDLS N+I +I + S E + +L L L N +L
Sbjct: 735 IRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWF 794
Query: 367 VGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDL 404
V + VTI +++ ++ +G + +G QS++ LDL
Sbjct: 795 VWWVNHTEVTIPYLAT-DVTCVGPGAHKG-QSVISLDL 830
>AB023148-1|BAA76775.2| 1258|Homo sapiens KIAA0931 protein protein.
Length = 1258
Score = 78.2 bits (184), Expect = 1e-13
Identities = 102/360 (28%), Positives = 161/360 (44%), Gaps = 38/360 (10%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T+++ S G D+P+ +G L + L + N T PE L L L +L IS N +P
Sbjct: 327 TELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIP 386
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM--GNLANQE 159
+ LT L+ + ++ N + LNL VL H+K +DL N +TM NL +
Sbjct: 387 E-VYEKLTMLDRVVMAGNCLEV-LNLG---VLNRMNHIKHVDLRMNHLKTMVIENLEGNK 441
Query: 160 LLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSN 219
+ L L + LS L ++ L N LR L SLR+L+ S+
Sbjct: 442 HITHVDLRDNRLTDLD---------LSSLCSLEQLHCGRNQ-LRELTLSGFSLRTLYASS 491
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQP---NL 276
LT++N + L LT L +S N LE ++ ++ +D+SY N+L +
Sbjct: 492 NRLTAVNVYPVPSL--LTFLDLSRNL-LECVPDW-ACEAKKIEVLDVSY-NLLTEVPVRI 546
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTF-------RGLKM 329
SLRK +L HN V+ L + + LE LDL +N + L F L+
Sbjct: 547 LSSLSLRKLMLGHNHVQNLPT--LVEHIPLEVLDLQHNALTRLPDTLFSKALNKLNKLEQ 604
Query: 330 LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM-SVTILDMSSCELNTI 388
L+ L+LS N++ IP ++ L L N +S + + + +D+S +L I
Sbjct: 605 LEELNLSGNKLKTIP-TTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEI 663
Score = 64.1 bits (149), Expect = 2e-09
Identities = 68/262 (25%), Positives = 122/262 (46%), Gaps = 16/262 (6%)
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
+++++ S L GL N+ KL P+L + S+L L +S C +++ L +
Sbjct: 294 LDTLYKFSQLKGL-NLSHNKLGLFPILLCE---ISTLTELNLS-CNGFHDLPSQIGNLLN 348
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNL-KGFPSLRKAILNHNMVR 293
L L + N+ L NL Q L + IS+ N Q P + + L + ++ N +
Sbjct: 349 LQTLCLDGNFLTTLPEELGNL--QQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLE 406
Query: 294 YLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPS 353
L ++++DL N++ ++ + G K + H+DL N + + SL S
Sbjct: 407 VLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLC---S 463
Query: 354 LTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIP 413
L QL RN L + L S+ L SS L + + L + LDLS+NLL +P
Sbjct: 464 LEQLHCGRNQLREL-TLSGFSLRTLYASSNRLTAVNVYPVPSL--LTFLDLSRNLLECVP 520
Query: 414 D-SISSNTLKYLNLNYNRISSI 434
D + + ++ L+++YN ++ +
Sbjct: 521 DWACEAKKIEVLDVSYNLLTEV 542
Score = 55.6 bits (128), Expect = 6e-07
Identities = 94/379 (24%), Positives = 163/379 (43%), Gaps = 50/379 (13%)
Query: 63 QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
Q+ LN+S+N+ FP L + L L++S N LP + + NL L+ L L N+
Sbjct: 302 QLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLP-SQIGNLLNLQTLCLDGNF-- 358
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGR 182
L P + L L L +SFN F + + + ++ ++ +C
Sbjct: 359 --LTTLPEE-LGNLQQLSSLGISFNNFSQIPEVYEKLTMLD---RVVMAGNC-------- 404
Query: 183 SPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
+ V LN L R+ ++ LR + + +L N+ +TH+ +
Sbjct: 405 --------LEV--LNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNK-----HITHVDLR 449
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFAN 302
+N +L S+ SL+ + + + L GF SLR + N R N +
Sbjct: 450 DNRLTDLDLSS----LCSLEQLHCGRNQLRELTLSGF-SLRTLYASSN--RLTAVNVYPV 502
Query: 303 NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
+ L +LDLS N + + D K ++ LD+S+N + +P +L SL +L L N
Sbjct: 503 PSLLTFLDLSRNLLECVP-DWACEAKKIEVLDVSYNLLTEVPV-RILSSLSLRKLMLGHN 560
Query: 363 YLSRVGHL-RSMSVTILDMSSCELNTI-------GKDSLEGLQSIVELDLSQNLLSYIPD 414
++ + L + + +LD+ L + + L L+ + EL+LS N L IP
Sbjct: 561 HVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNKLNKLEQLEELNLSGNKLKTIPT 620
Query: 415 SISS-NTLKYLNLNYNRIS 432
+I++ L L + N IS
Sbjct: 621 TIANCKRLHTLVAHSNNIS 639
>Z23091-1|CAA80637.1| 560|Homo sapiens platelet glycoprotein V
precursor protein.
Length = 560
Score = 77.8 bits (183), Expect = 1e-13
Identities = 98/352 (27%), Positives = 157/352 (44%), Gaps = 30/352 (8%)
Query: 139 LKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNF 198
LK L LS NK + ++++ LE L LDH + I ++ L+N++ L LN
Sbjct: 100 LKTLRLSRNKITHLPGALLDKMVL---LEQLFLDHNALRGID-QNMFQKLVNLQELALNQ 155
Query: 199 NPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS 258
N L + + +SL + + N +L L+ N L LP + RL L S N L S
Sbjct: 156 NQL----DFLPASLFTN-LENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHS--NRLVS 208
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+D N L +L + + N +R + AF L L LS N++A
Sbjct: 209 -----LDSGLLNSLG-------ALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAF 256
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-V 375
L F L L L N +A +P EM L +L L+R L + R++S +
Sbjct: 257 LPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRL 316
Query: 376 TILDMS-SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRIS 432
L ++ S L+ + + + +GL + L L N L+ +PD + L+ ++L NR+
Sbjct: 317 RYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLR 376
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
++ F L+ L S+ + N+ + F + P L + L N WRCDC
Sbjct: 377 ALPRALFRNLSSLESVQLDHNQLETL-PGDVFGALPRLTEVLLGHNSWRCDC 427
Score = 73.3 bits (172), Expect = 3e-12
Identities = 95/355 (26%), Positives = 161/355 (45%), Gaps = 40/355 (11%)
Query: 62 LQVTKLNISNNEFTKFPESL-SRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
+++ L +S N+ T P +L ++ L L + N L+G+ N L L+ L L++N
Sbjct: 98 IKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQ 157
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
D P + +LK+LDLS N + +L L + LE L+L + S+
Sbjct: 158 LD----FLPASLFTNLENLKLLDLSGNN---LTHLPKGLLGAQAKLERLLLHSNRLVSLD 210
Query: 181 GRSPLSGLINI--RVLKLNFNPLLRIQNLISSSLRSLF--VSNCELTSLNHNELMFLPSL 236
SGL+N + +L F+ +N I S F + N +L+ N L FLPS
Sbjct: 211 -----SGLLNSLGALTELQFH-----RNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
Query: 237 THLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLE 296
L +++ L L + LF L + +L + G L++ LN +R L
Sbjct: 261 LFL---HSHNLTLLT----LFENPLAELP----GVLFGEMGG---LQELWLNRTQLRTLP 306
Query: 297 SNAFANNTELEYLDLS-NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLT 355
+ AF N + L YL ++ + +++L F+GL L+ L L N + +P+ L + L
Sbjct: 307 AAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLR 366
Query: 356 QLKLSRNYLSRVGH--LRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
Q+ L RN L + R++ S+ + + +L T+ D L + E+ L N
Sbjct: 367 QVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Score = 54.0 bits (124), Expect = 2e-06
Identities = 55/246 (22%), Positives = 109/246 (44%), Gaps = 7/246 (2%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCN 270
L+ L +S+ ++++ L L L++S N L + + + ++D +
Sbjct: 76 LQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALR 135
Query: 271 ILQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKM 329
+ N+ + +L++ LN N + +L ++ F N L+ LDLS NN+ L
Sbjct: 136 GIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAK 195
Query: 330 LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSCELN 386
L+ L L N + + L + +LT+L+ RN++ + R +++ L +S L
Sbjct: 196 LERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLA 255
Query: 387 TIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNR 444
+ ++ L L +N L+ +P + L+ L LN ++ ++ F L+R
Sbjct: 256 FLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSR 315
Query: 445 LTSLSV 450
L L V
Sbjct: 316 LRYLGV 321
Score = 50.0 bits (114), Expect = 3e-05
Identities = 41/160 (25%), Positives = 79/160 (49%), Gaps = 5/160 (3%)
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY 363
T L ++ L L+ +F G+ +L+ L +S + I+ + + ++ L L+LSRN
Sbjct: 50 TNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNK 109
Query: 364 LSRV-GHLRSMSVTI--LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN- 419
++ + G L V + L + L I ++ + L ++ EL L+QN L ++P S+ +N
Sbjct: 110 ITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNL 169
Query: 420 -TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
LK L+L+ N ++ + +L L + NR +
Sbjct: 170 ENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSL 209
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/82 (30%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 52 GLTDIPNGL--GL-QVTKLNISNNEFTKFPESLSR-LHNLVNLDISSNQLKGLPDNALYN 107
GLT +P+GL GL ++ ++++ N P +L R L +L ++ + NQL+ LP +
Sbjct: 350 GLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGA 409
Query: 108 LTALEVLNLSRNYFDSWLNLNP 129
L L + L N + L P
Sbjct: 410 LPRLTEVLLGHNSWRCDCGLGP 431
>L11238-1|AAA03069.1| 560|Homo sapiens platelet membrane
glycoprotein V protein.
Length = 560
Score = 77.8 bits (183), Expect = 1e-13
Identities = 98/352 (27%), Positives = 157/352 (44%), Gaps = 30/352 (8%)
Query: 139 LKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNF 198
LK L LS NK + ++++ LE L LDH + I ++ L+N++ L LN
Sbjct: 100 LKTLRLSRNKITHLPGALLDKMVL---LEQLFLDHNALRGID-QNMFQKLVNLQELALNQ 155
Query: 199 NPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS 258
N L + + +SL + + N +L L+ N L LP + RL L S N L S
Sbjct: 156 NQL----DFLPASLFTN-LENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHS--NRLVS 208
Query: 259 QSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIAS 318
+D N L +L + + N +R + AF L L LS N++A
Sbjct: 209 -----LDSGLLNSLG-------ALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAF 256
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-V 375
L F L L L N +A +P EM L +L L+R L + R++S +
Sbjct: 257 LPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRL 316
Query: 376 TILDMS-SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRIS 432
L ++ S L+ + + + +GL + L L N L+ +PD + L+ ++L NR+
Sbjct: 317 RYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLR 376
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
++ F L+ L S+ + N+ + F + P L + L N WRCDC
Sbjct: 377 ALPRALFRNLSSLESVQLDHNQLETL-PGDVFGALPRLTEVLLGHNSWRCDC 427
Score = 73.3 bits (172), Expect = 3e-12
Identities = 95/355 (26%), Positives = 161/355 (45%), Gaps = 40/355 (11%)
Query: 62 LQVTKLNISNNEFTKFPESL-SRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
+++ L +S N+ T P +L ++ L L + N L+G+ N L L+ L L++N
Sbjct: 98 IKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQ 157
Query: 121 FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
D P + +LK+LDLS N + +L L + LE L+L + S+
Sbjct: 158 LD----FLPASLFTNLENLKLLDLSGNN---LTHLPKGLLGAQAKLERLLLHSNRLVSLD 210
Query: 181 GRSPLSGLINI--RVLKLNFNPLLRIQNLISSSLRSLF--VSNCELTSLNHNELMFLPSL 236
SGL+N + +L F+ +N I S F + N +L+ N L FLPS
Sbjct: 211 -----SGLLNSLGALTELQFH-----RNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
Query: 237 THLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLE 296
L +++ L L + LF L + +L + G L++ LN +R L
Sbjct: 261 LFL---HSHNLTLLT----LFENPLAELP----GVLFGEMGG---LQELWLNRTQLRTLP 306
Query: 297 SNAFANNTELEYLDLS-NNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLT 355
+ AF N + L YL ++ + +++L F+GL L+ L L N + +P+ L + L
Sbjct: 307 AAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLR 366
Query: 356 QLKLSRNYLSRVGH--LRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
Q+ L RN L + R++ S+ + + +L T+ D L + E+ L N
Sbjct: 367 QVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Score = 54.0 bits (124), Expect = 2e-06
Identities = 55/246 (22%), Positives = 109/246 (44%), Gaps = 7/246 (2%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCN 270
L+ L +S+ ++++ L L L++S N L + + + ++D +
Sbjct: 76 LQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALR 135
Query: 271 ILQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKM 329
+ N+ + +L++ LN N + +L ++ F N L+ LDLS NN+ L
Sbjct: 136 GIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAK 195
Query: 330 LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSCELN 386
L+ L L N + + L + +LT+L+ RN++ + R +++ L +S L
Sbjct: 196 LERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLA 255
Query: 387 TIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNR 444
+ ++ L L +N L+ +P + L+ L LN ++ ++ F L+R
Sbjct: 256 FLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSR 315
Query: 445 LTSLSV 450
L L V
Sbjct: 316 LRYLGV 321
Score = 50.0 bits (114), Expect = 3e-05
Identities = 41/160 (25%), Positives = 79/160 (49%), Gaps = 5/160 (3%)
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY 363
T L ++ L L+ +F G+ +L+ L +S + I+ + + ++ L L+LSRN
Sbjct: 50 TNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNK 109
Query: 364 LSRV-GHLRSMSVTI--LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN- 419
++ + G L V + L + L I ++ + L ++ EL L+QN L ++P S+ +N
Sbjct: 110 ITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNL 169
Query: 420 -TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
LK L+L+ N ++ + +L L + NR +
Sbjct: 170 ENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSL 209
Score = 33.9 bits (74), Expect = 2.1
Identities = 25/82 (30%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 52 GLTDIPNGL--GL-QVTKLNISNNEFTKFPESLSR-LHNLVNLDISSNQLKGLPDNALYN 107
GLT +P+GL GL ++ ++++ N P +L R L +L ++ + NQL+ LP +
Sbjct: 350 GLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGA 409
Query: 108 LTALEVLNLSRNYFDSWLNLNP 129
L L + L N + L P
Sbjct: 410 LPRLTEVLLGHNSWRCDCGLGP 431
>BC028292-1|AAH28292.1| 402|Homo sapiens PODN protein protein.
Length = 402
Score = 77.8 bits (183), Expect = 1e-13
Identities = 88/314 (28%), Positives = 143/314 (45%), Gaps = 26/314 (8%)
Query: 188 LINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRL 247
L ++ L L+ N L R+ + SL L + + S++ N L + SL +L + +N
Sbjct: 76 LSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLR 135
Query: 248 ELASSANNLFSQSLKYIDIS--YCNILQPNLKGFPS-LRKAILNHNMVRYLESNAFANNT 304
E + L Q LK + Y N L+ G P +R ++ HN + + FA
Sbjct: 136 E--QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTY 193
Query: 305 ELEYLDLSNNNIAS--LRYDTFRGLKMLKHLDLSWNEIAVIPED-----SLLEMPSLTQL 357
LE L+LS N I S + D FR L++L+ LDLS N + +P +L++
Sbjct: 194 FLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELA 253
Query: 358 KLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSIS 417
L+R L+ + LR + +T + S +G + L + LD++ N L+ IP+ +
Sbjct: 254 ALARGALAGMAQLRELYLTSNRLRS---RALGPRAWVDLAHLQLLDIAGNQLTEIPEGL- 309
Query: 418 SNTLKYLNLNYNRISSI--------NNL--TFFMLNRLTSLSVVGNRFTMIWRRSFFDSN 467
+L+YL L N+IS++ NL F N+L SVV + F + D
Sbjct: 310 PESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIE 369
Query: 468 PYLERLDLSDNMWR 481
LE D+S + R
Sbjct: 370 GNLEFGDISKDRGR 383
Score = 70.1 bits (164), Expect = 3e-11
Identities = 93/325 (28%), Positives = 153/325 (47%), Gaps = 26/325 (8%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL--KGLPDNALYNLT 109
L +P L + KL++ NN+ K P + S L +L L + +N L +GL + + L+
Sbjct: 18 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 77
Query: 110 ALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETL 169
+LE L+LS N NL+ LP + L +L L N +++ AN IR SLE L
Sbjct: 78 SLEYLDLSSN------NLSRVPAGLPRS-LVLLHLEKNAIRSVD--ANVLTPIR-SLEYL 127
Query: 170 ILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNH 227
+L ++ G PL+ GL + + L N L R+ + + +R+L + + ++T +
Sbjct: 128 LLHSNQLRE-QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 186
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNILQPNLKGFP-SLRK 284
+ L L +S N R+ + F + L+ +D+S N L G P ++
Sbjct: 187 EDFATTYFLEELNLSYN-RITSPQVHRDAFRKLRLLRSLDLS-GNRLHTLPPGLPRNVHV 244
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIAS--LRYDTFRGLKMLKHLDLSWNEIAV 342
+ N + L A A +L L L++N + S L + L L+ LD++ N++
Sbjct: 245 LKVKRNELAALARGALAGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTE 304
Query: 343 IPEDSLLEMPSLTQLKLSRNYLSRV 367
IPE L E SL L L N +S V
Sbjct: 305 IPE-GLPE--SLEYLYLQNNKISAV 326
Score = 52.8 bits (121), Expect = 4e-06
Identities = 105/405 (25%), Positives = 175/405 (43%), Gaps = 56/405 (13%)
Query: 64 VTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF-D 122
V L +S+N P+ L L L + +N+L+ +P A L++L L L NY D
Sbjct: 8 VEVLILSSNFLRHVPKHLPPA--LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD 65
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGR 182
L+ N+ + L+ LDLS N NL+ + SL L L+ I S+
Sbjct: 66 EGLD---NETFWKLSSLEYLDLSSN------NLSRVPAGLPRSLVLLHLEKNAIRSVDA- 115
Query: 183 SPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
+ L+ + ++ L L+ N LR Q + + + L L +N L +PS ++
Sbjct: 116 NVLTPIRSLEYLLLHSNQ-LREQGIHPLAFQGL--KRLHTVHLYNNALERVPSGLPRRVR 172
Query: 243 NNYRL--ELASSANNLFSQS--LKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESN 298
L ++ F+ + L+ +++SY I P + +
Sbjct: 173 TLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQ-------------------VHRD 213
Query: 299 AFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLK 358
AF L LDLS N + +L R + +LK + NE+A + +L M L +L
Sbjct: 214 AFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK---VKRNELAALARGALAGMAQLRELY 270
Query: 359 LSRNYL-SRVGHLRS----MSVTILDMSSCELNTIGKDSLEGL-QSIVELDLSQNLLSYI 412
L+ N L SR R+ + +LD++ +L I EGL +S+ L L N +S +
Sbjct: 271 LTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP----EGLPESLEYLYLQNNKISAV 326
Query: 413 PDSISSNT--LKYLNLNYNR--ISSINNLTFFMLNRLTSLSVVGN 453
P + +T LK + L +N+ + S+ + F L L L + GN
Sbjct: 327 PANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 371
Score = 49.6 bits (113), Expect = 4e-05
Identities = 56/182 (30%), Positives = 87/182 (47%), Gaps = 11/182 (6%)
Query: 281 SLRKAILNHNMV--RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
SLR+ L +N + L++ F + LEYLDLS+NN++ + R L +L HL+ N
Sbjct: 52 SLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLL-HLEK--N 108
Query: 339 EIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-H-LRSMSVTILDMSSCELNTIGKDSLEGL 396
I + + L + SL L L N L G H L + L N + +
Sbjct: 109 AIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLP 168
Query: 397 QSIVELDLSQNLLSYI--PDSISSNTLKYLNLNYNRISS--INNLTFFMLNRLTSLSVVG 452
+ + L + N ++ I D ++ L+ LNL+YNRI+S ++ F L L SL + G
Sbjct: 169 RRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSG 228
Query: 453 NR 454
NR
Sbjct: 229 NR 230
Score = 32.7 bits (71), Expect = 4.9
Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLK--GLPD 102
+D + LT+IP GL + L + NN+ + P + NL + + N+L + D
Sbjct: 295 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 354
Query: 103 NALYNLTALEVLNLSRN 119
+A L L+VL++ N
Sbjct: 355 SAFRRLKHLQVLDIEGN 371
>U96769-1|AAC13410.1| 359|Homo sapiens chondroadherin protein.
Length = 359
Score = 77.4 bits (182), Expect = 2e-13
Identities = 71/268 (26%), Positives = 121/268 (45%), Gaps = 14/268 (5%)
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNA 299
NN+ + A+S + +L + + +C I + F L++ I L+HN +R + + A
Sbjct: 61 NNFPVLAANSFRAM--PNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVVRAGA 118
Query: 300 FANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKL 359
F + TEL YL L +N + L L L L L+ N+I + L L L
Sbjct: 119 FDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGPFQGAKDLRWLYL 178
Query: 360 SRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI 416
S N LS + G L + ++ + +L++ +L L+ + EL LS N L IPD+
Sbjct: 179 SENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNA 238
Query: 417 SSNTLKYLN---LNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERL 473
+ +YL L+ + ++ F + L + + NR + FDS LE L
Sbjct: 239 FQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDS---LETL 295
Query: 474 DLSDNMWRCDCSDENMRDFYDFVTLEPN 501
L++N W+C C +R + + P+
Sbjct: 296 ALTNNPWKCTCQLRGLRRWLEAKASRPD 323
Score = 50.8 bits (116), Expect = 2e-05
Identities = 74/285 (25%), Positives = 121/285 (42%), Gaps = 18/285 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ D + C + GL IP + + LN+ N F S + NLV+L +
Sbjct: 27 CHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHC 85
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
Q++ + A L L L LS N + D L T L L L NK +
Sbjct: 86 QIREVAAGAFRGLKQLIYLYLSHNDI-RVVRAGAFDDL---TELTYLYLDHNKVTELPRG 141
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
L+ +L L L++ +I + P G ++R L L+ N L +Q + +L
Sbjct: 142 LLSPLV---NLFILQLNNNKIRELRA-GPFQGAKDLRWLYLSENALSSLQPGALDDVENL 197
Query: 216 ---FVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL 272
V +L+S L L + LK+S+N + +A F + L+ + + N+
Sbjct: 198 AKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLE 257
Query: 273 QPN---LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+ + G +L+ L +N + L SN F ++ LE L L+NN
Sbjct: 258 KFSDGAFLGVTTLKHVHLENNRLNQLPSN-FPFDS-LETLALTNN 300
Score = 45.6 bits (103), Expect = 7e-04
Identities = 72/272 (26%), Positives = 118/272 (43%), Gaps = 46/272 (16%)
Query: 112 EVLNLSRNYFD----SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA------NQELL 161
++LNL RN F + PN V L H +I +++ F+ + L N +
Sbjct: 54 KLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRV 113
Query: 162 IRPS-------LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSS 211
+R L L LDH ++ + R LS L+N+ +L+LN N + ++ +
Sbjct: 114 VRAGAFDDLTELTYLYLDHNKVTELP-RGLLSPLVNLFILQLNNNKIRELRAGPFQGAKD 172
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI 271
LR L++S L+SL L + +L + N +L+S + S+ L+ ++
Sbjct: 173 LRWLYLSENALSSLQPGALDDVENLAKFHVDRN---QLSSYPSAALSK-LRVVE------ 222
Query: 272 LQPNLKGFPSLRKAILNHNMVRYLESNAFAN-NTELEYLDLSNNNIASLRYDTFRGLKML 330
LK L+HN ++ + NAF + LE L L N N+ F G+ L
Sbjct: 223 ---ELK---------LSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTL 270
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
KH+ L N + +P S SL L L+ N
Sbjct: 271 KHVHLENNRLNQLP--SNFPFDSLETLALTNN 300
>BC113717-1|AAI13718.1| 581|Homo sapiens leucine rich repeat
transmembrane neuronal 3 protein.
Length = 581
Score = 77.4 bits (182), Expect = 2e-13
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 7/224 (3%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL+Y + Q KG L L+HN + ++ NAF L+ L LS+N I+
Sbjct: 67 SLRYNSLQKLKYNQ--FKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVT 376
+TFR + L++LDLS+N++ + + + L L L N L + ++
Sbjct: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
Query: 377 ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSI 434
+LD+ + ++ ++ G+ + EL L N S + ++ +L+ L L +N+IS I
Sbjct: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
+ + L L + GN S F P L+RL+L N
Sbjct: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSN 288
Score = 75.4 bits (177), Expect = 7e-13
Identities = 72/270 (26%), Positives = 122/270 (45%), Gaps = 13/270 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D ++ + + N G L++ IL+ N + Y +N F T L LDLS N + SL
Sbjct: 91 YLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMS 381
+ FRGL+ L L L N + IP + +L L L N + + + L
Sbjct: 151 EQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKEL 210
Query: 382 SCELNTIGKDSL---EGLQSIVELDLSQNLLSYIPDSIS--SNTLKYLNLNYNRISSINN 436
E N K +L L S+ L L N +S I ++S ++L+ L+L+ N I + +
Sbjct: 211 HLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSG 270
Query: 437 LTFFM-LNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDF 495
+ F + L L++ N+ T I + DS L + L+ N+W C N+ ++
Sbjct: 271 PSVFQCVPNLQRLNLDSNKLTFI-GQEILDSWISLNDISLAGNIWEC---SRNICSLVNW 326
Query: 496 VTLEPNKKEESFNLICNSPANVNTQTWLEA 525
+ +E + +IC SP + ++A
Sbjct: 327 LKSFKGLRENT--IICASPKELQGVNVIDA 354
Score = 71.7 bits (168), Expect = 9e-12
Identities = 51/155 (32%), Positives = 80/155 (51%), Gaps = 5/155 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
L L N++ L+Y+ F+GL L L L N I+ I E++ + L +L LS N +S
Sbjct: 66 LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
Query: 369 HLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKY 423
+ VT LD+S +L+++G + GL+ ++ L L N L IP I L+
Sbjct: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
L+L YNRI S+ F + RL L + N+F+ +
Sbjct: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKL 220
Score = 53.6 bits (123), Expect = 2e-06
Identities = 64/286 (22%), Positives = 128/286 (44%), Gaps = 19/286 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSN 95
CRC + + C + L +IP+ + L++ N K L+ L L + N
Sbjct: 38 CRC--EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + +NA + L+ L LS N +LN + P T+L+ LDLS+N+ ++G
Sbjct: 96 HISNIDENAFNGIRRLKELILSSNRISYFLN----NTFRPVTNLRNLDLSYNQLHSLG-- 149
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI-QNLISSSLR- 213
+++ L +L L + +I R N+ +L L +N + + +N+ + +R
Sbjct: 150 -SEQFRGLRKLLSLHLRSNSLRTIPVRI-FQDCRNLELLDLGYNRIRSLARNVFAGMIRL 207
Query: 214 -SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI- 271
L + + + + LN L SL +L + N ++ + + SL+ +D+S I
Sbjct: 208 KELHLEHNQFSKLNLALFPRLVSLQNLYLQWN-KISVIGQTMSWTWSSLQRLDLSGNEIE 266
Query: 272 --LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
P++ + P+L++ L+ N + ++ + L + L+ N
Sbjct: 267 AFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
>BC113715-1|AAI13716.1| 581|Homo sapiens leucine rich repeat
transmembrane neuronal 3 protein.
Length = 581
Score = 77.4 bits (182), Expect = 2e-13
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 7/224 (3%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL+Y + Q KG L L+HN + ++ NAF L+ L LS+N I+
Sbjct: 67 SLRYNSLQKLKYNQ--FKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVT 376
+TFR + L++LDLS+N++ + + + L L L N L + ++
Sbjct: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
Query: 377 ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSI 434
+LD+ + ++ ++ G+ + EL L N S + ++ +L+ L L +N+IS I
Sbjct: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
+ + L L + GN S F P L+RL+L N
Sbjct: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSN 288
Score = 75.4 bits (177), Expect = 7e-13
Identities = 72/270 (26%), Positives = 122/270 (45%), Gaps = 13/270 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D ++ + + N G L++ IL+ N + Y +N F T L LDLS N + SL
Sbjct: 91 YLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMS 381
+ FRGL+ L L L N + IP + +L L L N + + + L
Sbjct: 151 EQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKEL 210
Query: 382 SCELNTIGKDSL---EGLQSIVELDLSQNLLSYIPDSIS--SNTLKYLNLNYNRISSINN 436
E N K +L L S+ L L N +S I ++S ++L+ L+L+ N I + +
Sbjct: 211 HLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSG 270
Query: 437 LTFFM-LNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDF 495
+ F + L L++ N+ T I + DS L + L+ N+W C N+ ++
Sbjct: 271 PSVFQCVPNLQRLNLDSNKLTFI-GQEILDSWISLNDISLAGNIWEC---SRNICSLVNW 326
Query: 496 VTLEPNKKEESFNLICNSPANVNTQTWLEA 525
+ +E + +IC SP + ++A
Sbjct: 327 LKSFKGLRENT--IICASPKELQGVNVIDA 354
Score = 71.7 bits (168), Expect = 9e-12
Identities = 51/155 (32%), Positives = 80/155 (51%), Gaps = 5/155 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
L L N++ L+Y+ F+GL L L L N I+ I E++ + L +L LS N +S
Sbjct: 66 LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
Query: 369 HLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKY 423
+ VT LD+S +L+++G + GL+ ++ L L N L IP I L+
Sbjct: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
L+L YNRI S+ F + RL L + N+F+ +
Sbjct: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKL 220
Score = 53.6 bits (123), Expect = 2e-06
Identities = 64/286 (22%), Positives = 128/286 (44%), Gaps = 19/286 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSN 95
CRC + + C + L +IP+ + L++ N K L+ L L + N
Sbjct: 38 CRC--EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + +NA + L+ L LS N +LN + P T+L+ LDLS+N+ ++G
Sbjct: 96 HISNIDENAFNGIRRLKELILSSNRISYFLN----NTFRPVTNLRNLDLSYNQLHSLG-- 149
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI-QNLISSSLR- 213
+++ L +L L + +I R N+ +L L +N + + +N+ + +R
Sbjct: 150 -SEQFRGLRKLLSLHLRSNSLRTIPVRI-FQDCRNLELLDLGYNRIRSLARNVFAGMIRL 207
Query: 214 -SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI- 271
L + + + + LN L SL +L + N ++ + + SL+ +D+S I
Sbjct: 208 KELHLEHNQFSKLNLALFPRLVSLQNLYLQWN-KISVIGQTMSWTWSSLQRLDLSGNEIE 266
Query: 272 --LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
P++ + P+L++ L+ N + ++ + L + L+ N
Sbjct: 267 AFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
>BC111492-1|AAI11493.1| 581|Homo sapiens leucine rich repeat
transmembrane neuronal 3 protein.
Length = 581
Score = 77.4 bits (182), Expect = 2e-13
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 7/224 (3%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL+Y + Q KG L L+HN + ++ NAF L+ L LS+N I+
Sbjct: 67 SLRYNSLQKLKYNQ--FKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVT 376
+TFR + L++LDLS+N++ + + + L L L N L + ++
Sbjct: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
Query: 377 ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSI 434
+LD+ + ++ ++ G+ + EL L N S + ++ +L+ L L +N+IS I
Sbjct: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
+ + L L + GN S F P L+RL+L N
Sbjct: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSN 288
Score = 75.4 bits (177), Expect = 7e-13
Identities = 72/270 (26%), Positives = 122/270 (45%), Gaps = 13/270 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D ++ + + N G L++ IL+ N + Y +N F T L LDLS N + SL
Sbjct: 91 YLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMS 381
+ FRGL+ L L L N + IP + +L L L N + + + L
Sbjct: 151 EQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKEL 210
Query: 382 SCELNTIGKDSL---EGLQSIVELDLSQNLLSYIPDSIS--SNTLKYLNLNYNRISSINN 436
E N K +L L S+ L L N +S I ++S ++L+ L+L+ N I + +
Sbjct: 211 HLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSG 270
Query: 437 LTFFM-LNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDF 495
+ F + L L++ N+ T I + DS L + L+ N+W C N+ ++
Sbjct: 271 PSVFQCVPNLQRLNLDSNKLTFI-GQEILDSWISLNDISLAGNIWEC---SRNICSLVNW 326
Query: 496 VTLEPNKKEESFNLICNSPANVNTQTWLEA 525
+ +E + +IC SP + ++A
Sbjct: 327 LKSFKGLRENT--IICASPKELQGVNVIDA 354
Score = 71.7 bits (168), Expect = 9e-12
Identities = 51/155 (32%), Positives = 80/155 (51%), Gaps = 5/155 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
L L N++ L+Y+ F+GL L L L N I+ I E++ + L +L LS N +S
Sbjct: 66 LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
Query: 369 HLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKY 423
+ VT LD+S +L+++G + GL+ ++ L L N L IP I L+
Sbjct: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
L+L YNRI S+ F + RL L + N+F+ +
Sbjct: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKL 220
Score = 53.6 bits (123), Expect = 2e-06
Identities = 64/286 (22%), Positives = 128/286 (44%), Gaps = 19/286 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSN 95
CRC + + C + L +IP+ + L++ N K L+ L L + N
Sbjct: 38 CRC--EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + +NA + L+ L LS N +LN + P T+L+ LDLS+N+ ++G
Sbjct: 96 HISNIDENAFNGIRRLKELILSSNRISYFLN----NTFRPVTNLRNLDLSYNQLHSLG-- 149
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI-QNLISSSLR- 213
+++ L +L L + +I R N+ +L L +N + + +N+ + +R
Sbjct: 150 -SEQFRGLRKLLSLHLRSNSLRTIPVRI-FQDCRNLELLDLGYNRIRSLARNVFAGMIRL 207
Query: 214 -SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI- 271
L + + + + LN L SL +L + N ++ + + SL+ +D+S I
Sbjct: 208 KELHLEHNQFSKLNLALFPRLVSLQNLYLQWN-KISVIGQTMSWTWSSLQRLDLSGNEIE 266
Query: 272 --LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
P++ + P+L++ L+ N + ++ + L + L+ N
Sbjct: 267 AFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
>BC068558-1|AAH68558.1| 614|Homo sapiens LINGO1 protein protein.
Length = 614
Score = 77.4 bits (182), Expect = 2e-13
Identities = 70/279 (25%), Positives = 130/279 (46%), Gaps = 10/279 (3%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDI 266
I + R L + + +LN +E P L L+++ N + A NNLF+ +
Sbjct: 63 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRS 122
Query: 267 SYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+ ++ + G +L K ++ N + L F + L L++ +N++ + + F
Sbjct: 123 NRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLRSLEVGDNDLVYISHRAFS 182
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR---NYLSRVGHLRSMSVTILDMSS 382
GL L+ L L + IP ++L + L L+L N + R + +L++S
Sbjct: 183 GLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISH 242
Query: 383 CE-LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTF 439
L+T+ + L GL ++ L ++ L+ +P + L++LNL+YNRIS+I
Sbjct: 243 WPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNRISTIEGSML 301
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L RL + +VG + ++ +F N YL L++S N
Sbjct: 302 HELLRLQEIQLVGGQLAVVEPYAFRGLN-YLRVLNVSGN 339
Score = 70.1 bits (164), Expect = 3e-11
Identities = 80/333 (24%), Positives = 139/333 (41%), Gaps = 14/333 (4%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSNQL 97
C+ + C R+ +P G+ + L++ N T + + +L L+++ N +
Sbjct: 42 CSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIV 101
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLAN 157
+ A NL L L L N L L P V ++L LD+S NK + +
Sbjct: 102 SAVEPGAFNNLFNLRTLGLRSNR----LKLIPLGVFTGLSNLTKLDISENKIVILLDYMF 157
Query: 158 QELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFV 217
Q+L SLE + D+ + H SGL ++ L L L I S L L V
Sbjct: 158 QDLYNLRSLE--VGDNDLVYISH--RAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIV 213
Query: 218 SNCELTSLNHNELMFLPSLTHLKM--SNNYRLELASSANNLFSQSLKYIDISYCNILQ-P 274
++N L LK+ +++ + N L+ +L + I++CN+ P
Sbjct: 214 LRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVP 273
Query: 275 NL--KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
L + LR L++N + +E + L+ + L +A + FRGL L+
Sbjct: 274 YLAVRHLVYLRFLNLSYNRISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRV 333
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
L++S N++ + E + +L L L N L+
Sbjct: 334 LNVSGNQLTTLEESVFHSVGNLETLILDSNPLA 366
>AY358315-1|AAQ88681.1| 513|Homo sapiens GFNV803 protein.
Length = 513
Score = 77.4 bits (182), Expect = 2e-13
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 7/224 (3%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL+Y + Q KG L L+HN + ++ NAF L+ L LS+N I+
Sbjct: 67 SLRYNSLQKLKYNQ--FKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVT 376
+TFR + L++LDLS+N++ + + + L L L N L + ++
Sbjct: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
Query: 377 ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSI 434
+LD+ + ++ ++ G+ + EL L N S + ++ +L+ L L +N+IS I
Sbjct: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
+ + L L + GN S F P L+RL+L N
Sbjct: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSN 288
Score = 75.4 bits (177), Expect = 7e-13
Identities = 72/270 (26%), Positives = 122/270 (45%), Gaps = 13/270 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D ++ + + N G L++ IL+ N + Y +N F T L LDLS N + SL
Sbjct: 91 YLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMS 381
+ FRGL+ L L L N + IP + +L L L N + + + L
Sbjct: 151 EQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKEL 210
Query: 382 SCELNTIGKDSL---EGLQSIVELDLSQNLLSYIPDSIS--SNTLKYLNLNYNRISSINN 436
E N K +L L S+ L L N +S I ++S ++L+ L+L+ N I + +
Sbjct: 211 HLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSG 270
Query: 437 LTFFM-LNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDF 495
+ F + L L++ N+ T I + DS L + L+ N+W C N+ ++
Sbjct: 271 PSVFQCVPNLQRLNLDSNKLTFI-GQEILDSWISLNDISLAGNIWEC---SRNICSLVNW 326
Query: 496 VTLEPNKKEESFNLICNSPANVNTQTWLEA 525
+ +E + +IC SP + ++A
Sbjct: 327 LKSFKGLRENT--IICASPKELQGVNVIDA 354
Score = 71.7 bits (168), Expect = 9e-12
Identities = 51/155 (32%), Positives = 80/155 (51%), Gaps = 5/155 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
L L N++ L+Y+ F+GL L L L N I+ I E++ + L +L LS N +S
Sbjct: 66 LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
Query: 369 HLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKY 423
+ VT LD+S +L+++G + GL+ ++ L L N L IP I L+
Sbjct: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
L+L YNRI S+ F + RL L + N+F+ +
Sbjct: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKL 220
Score = 53.6 bits (123), Expect = 2e-06
Identities = 64/286 (22%), Positives = 128/286 (44%), Gaps = 19/286 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSN 95
CRC + + C + L +IP+ + L++ N K L+ L L + N
Sbjct: 38 CRC--EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + +NA + L+ L LS N +LN + P T+L+ LDLS+N+ ++G
Sbjct: 96 HISNIDENAFNGIRRLKELILSSNRISYFLN----NTFRPVTNLRNLDLSYNQLHSLG-- 149
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI-QNLISSSLR- 213
+++ L +L L + +I R N+ +L L +N + + +N+ + +R
Sbjct: 150 -SEQFRGLRKLLSLHLRSNSLRTIPVRI-FQDCRNLELLDLGYNRIRSLARNVFAGMIRL 207
Query: 214 -SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI- 271
L + + + + LN L SL +L + N ++ + + SL+ +D+S I
Sbjct: 208 KELHLEHNQFSKLNLALFPRLVSLQNLYLQWN-KISVIGQTMSWTWSSLQRLDLSGNEIE 266
Query: 272 --LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
P++ + P+L++ L+ N + ++ + L + L+ N
Sbjct: 267 AFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
>AY182028-1|AAO67549.1| 513|Homo sapiens leucine-rich repeat
transmembrane neuronal 3 protein protein.
Length = 513
Score = 77.4 bits (182), Expect = 2e-13
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 7/224 (3%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL+Y + Q KG L L+HN + ++ NAF L+ L LS+N I+
Sbjct: 67 SLRYNSLQKLKYNQ--FKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVT 376
+TFR + L++LDLS+N++ + + + L L L N L + ++
Sbjct: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
Query: 377 ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSI 434
+LD+ + ++ ++ G+ + EL L N S + ++ +L+ L L +N+IS I
Sbjct: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
Query: 435 NNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
+ + L L + GN S F P L+RL+L N
Sbjct: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSN 288
Score = 75.4 bits (177), Expect = 7e-13
Identities = 72/270 (26%), Positives = 122/270 (45%), Gaps = 13/270 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D ++ + + N G L++ IL+ N + Y +N F T L LDLS N + SL
Sbjct: 91 YLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMS 381
+ FRGL+ L L L N + IP + +L L L N + + + L
Sbjct: 151 EQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKEL 210
Query: 382 SCELNTIGKDSL---EGLQSIVELDLSQNLLSYIPDSIS--SNTLKYLNLNYNRISSINN 436
E N K +L L S+ L L N +S I ++S ++L+ L+L+ N I + +
Sbjct: 211 HLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSG 270
Query: 437 LTFFM-LNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDF 495
+ F + L L++ N+ T I + DS L + L+ N+W C N+ ++
Sbjct: 271 PSVFQCVPNLQRLNLDSNKLTFI-GQEILDSWISLNDISLAGNIWEC---SRNICSLVNW 326
Query: 496 VTLEPNKKEESFNLICNSPANVNTQTWLEA 525
+ +E + +IC SP + ++A
Sbjct: 327 LKSFKGLRENT--IICASPKELQGVNVIDA 354
Score = 71.7 bits (168), Expect = 9e-12
Identities = 51/155 (32%), Positives = 80/155 (51%), Gaps = 5/155 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
L L N++ L+Y+ F+GL L L L N I+ I E++ + L +L LS N +S
Sbjct: 66 LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
Query: 369 HLRSMSVT---ILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKY 423
+ VT LD+S +L+++G + GL+ ++ L L N L IP I L+
Sbjct: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
L+L YNRI S+ F + RL L + N+F+ +
Sbjct: 186 LDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKL 220
Score = 53.6 bits (123), Expect = 2e-06
Identities = 64/286 (22%), Positives = 128/286 (44%), Gaps = 19/286 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSN 95
CRC + + C + L +IP+ + L++ N K L+ L L + N
Sbjct: 38 CRC--EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + +NA + L+ L LS N +LN + P T+L+ LDLS+N+ ++G
Sbjct: 96 HISNIDENAFNGIRRLKELILSSNRISYFLN----NTFRPVTNLRNLDLSYNQLHSLG-- 149
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI-QNLISSSLR- 213
+++ L +L L + +I R N+ +L L +N + + +N+ + +R
Sbjct: 150 -SEQFRGLRKLLSLHLRSNSLRTIPVRI-FQDCRNLELLDLGYNRIRSLARNVFAGMIRL 207
Query: 214 -SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI- 271
L + + + + LN L SL +L + N ++ + + SL+ +D+S I
Sbjct: 208 KELHLEHNQFSKLNLALFPRLVSLQNLYLQWN-KISVIGQTMSWTWSSLQRLDLSGNEIE 266
Query: 272 --LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
P++ + P+L++ L+ N + ++ + L + L+ N
Sbjct: 267 AFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGN 312
>BC126410-1|AAI26411.1| 516|Homo sapiens leucine rich repeat
transmembrane neuronal 2 protein.
Length = 516
Score = 76.2 bits (179), Expect = 4e-13
Identities = 60/197 (30%), Positives = 101/197 (51%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L HN + LE + FA+ ++L +L L +N I++++ D F+GL LK L LS N+I +P
Sbjct: 68 LRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNT 127
Query: 347 SLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ ++ +L L LS N LS + + L + S L TI +S+ LD
Sbjct: 128 TFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLD 187
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
LS N L + + + +K L+L +N+++ IN F L+ L +L + N+ + +
Sbjct: 188 LSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCG 247
Query: 462 SFFDSNPYLERLDLSDN 478
+ LE+LDL+ N
Sbjct: 248 MEWTWGT-LEKLDLTGN 263
Score = 74.5 bits (175), Expect = 1e-12
Identities = 82/315 (26%), Positives = 137/315 (43%), Gaps = 19/315 (6%)
Query: 239 LKMSNNYRLELASSANNLFSQSLKYIDISY---CNILQPNLKGFPSLRKAILNHNMVRYL 295
L + +N+ EL FSQ L ++ + + + + +G L++ IL+ N + YL
Sbjct: 66 LSLRHNHITELERDQFASFSQ-LTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYL 124
Query: 296 ESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLT 355
+ F L+ LDLS N ++SL + F GL+ L+ L L N + IP + SL
Sbjct: 125 PNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLE 184
Query: 356 QLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYI 412
L LS N L+R G + + L + +L I L S+ L L N +S +
Sbjct: 185 FLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNL 244
Query: 413 PDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYL 470
+ + TL+ L+L N I +I+ F + L L + N+ + +S L
Sbjct: 245 TCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSL-DSKILNSLRSL 303
Query: 471 ERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANVNTQTWLEACY--- 527
+ LS N+W C + ++ + E S ++C+SP + + L+A +
Sbjct: 304 TTVGLSGNLWECSA---RICALASWLGSFQGRWEHS--ILCHSPDHTQGEDILDAVHGFQ 358
Query: 528 FTWN-PTEKTANADT 541
WN T T A T
Sbjct: 359 LCWNLSTTVTVMATT 373
Score = 52.8 bits (121), Expect = 4e-06
Identities = 74/302 (24%), Positives = 126/302 (41%), Gaps = 28/302 (9%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C +K C +G +PN L++ +N T+ + + L L + NQ
Sbjct: 37 KCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQ 96
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ + ++A L L+ L LS N + PN +L+ LDLSFN+ ++
Sbjct: 97 ISTVKEDAFQGLYKLKELILSSNK----IFYLPNTTFTQLINLQNLDLSFNQLSSL---- 148
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
+ EL L L H NS+ P+ + R L+ R+++L + L
Sbjct: 149 HPELFY--GLRKLQTLHLRSNSLR-TIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGL- 204
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ EL L HN+ LT + ++ RL SS + LF Q K +++ C +
Sbjct: 205 IKLREL-HLEHNQ------LTKINFAHFLRL---SSLHTLFLQWNKISNLT-CGMEWT-- 251
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+ +L K L N ++ ++ F L+ L + NN + SL L+ L + LS
Sbjct: 252 --WGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLS 309
Query: 337 WN 338
N
Sbjct: 310 GN 311
>BC126408-1|AAI26409.1| 516|Homo sapiens leucine rich repeat
transmembrane neuronal 2 protein.
Length = 516
Score = 76.2 bits (179), Expect = 4e-13
Identities = 60/197 (30%), Positives = 101/197 (51%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L HN + LE + FA+ ++L +L L +N I++++ D F+GL LK L LS N+I +P
Sbjct: 68 LRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNT 127
Query: 347 SLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ ++ +L L LS N LS + + L + S L TI +S+ LD
Sbjct: 128 TFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLD 187
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
LS N L + + + +K L+L +N+++ IN F L+ L +L + N+ + +
Sbjct: 188 LSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCG 247
Query: 462 SFFDSNPYLERLDLSDN 478
+ LE+LDL+ N
Sbjct: 248 MEWTWGT-LEKLDLTGN 263
Score = 74.5 bits (175), Expect = 1e-12
Identities = 82/315 (26%), Positives = 137/315 (43%), Gaps = 19/315 (6%)
Query: 239 LKMSNNYRLELASSANNLFSQSLKYIDISY---CNILQPNLKGFPSLRKAILNHNMVRYL 295
L + +N+ EL FSQ L ++ + + + + +G L++ IL+ N + YL
Sbjct: 66 LSLRHNHITELERDQFASFSQ-LTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYL 124
Query: 296 ESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLT 355
+ F L+ LDLS N ++SL + F GL+ L+ L L N + IP + SL
Sbjct: 125 PNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLE 184
Query: 356 QLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYI 412
L LS N L+R G + + L + +L I L S+ L L N +S +
Sbjct: 185 FLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNL 244
Query: 413 PDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYL 470
+ + TL+ L+L N I +I+ F + L L + N+ + +S L
Sbjct: 245 TCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSL-DSKILNSLRSL 303
Query: 471 ERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANVNTQTWLEACY--- 527
+ LS N+W C + ++ + E S ++C+SP + + L+A +
Sbjct: 304 TTVGLSGNLWECSA---RICALASWLGSFQGRWEHS--ILCHSPDHTQGEDILDAVHGFQ 358
Query: 528 FTWN-PTEKTANADT 541
WN T T A T
Sbjct: 359 LCWNLSTTVTVMATT 373
Score = 52.8 bits (121), Expect = 4e-06
Identities = 74/302 (24%), Positives = 126/302 (41%), Gaps = 28/302 (9%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C +K C +G +PN L++ +N T+ + + L L + NQ
Sbjct: 37 KCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQ 96
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ + ++A L L+ L LS N + PN +L+ LDLSFN+ ++
Sbjct: 97 ISTVKEDAFQGLYKLKELILSSNK----IFYLPNTTFTQLINLQNLDLSFNQLSSL---- 148
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
+ EL L L H NS+ P+ + R L+ R+++L + L
Sbjct: 149 HPELFY--GLRKLQTLHLRSNSLR-TIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGL- 204
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ EL L HN+ LT + ++ RL SS + LF Q K +++ C +
Sbjct: 205 IKLREL-HLEHNQ------LTKINFAHFLRL---SSLHTLFLQWNKISNLT-CGMEWT-- 251
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+ +L K L N ++ ++ F L+ L + NN + SL L+ L + LS
Sbjct: 252 --WGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLS 309
Query: 337 WN 338
N
Sbjct: 310 GN 311
>AY182026-1|AAO67547.1| 516|Homo sapiens leucine-rich repeat
transmembrane neuronal 2 protein protein.
Length = 516
Score = 76.2 bits (179), Expect = 4e-13
Identities = 60/197 (30%), Positives = 101/197 (51%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L HN + LE + FA+ ++L +L L +N I++++ D F+GL LK L LS N+I +P
Sbjct: 68 LRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNT 127
Query: 347 SLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ ++ +L L LS N LS + + L + S L TI +S+ LD
Sbjct: 128 TFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLD 187
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
LS N L + + + +K L+L +N+++ IN F L+ L +L + N+ + +
Sbjct: 188 LSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCG 247
Query: 462 SFFDSNPYLERLDLSDN 478
+ LE+LDL+ N
Sbjct: 248 MEWTWGT-LEKLDLTGN 263
Score = 74.5 bits (175), Expect = 1e-12
Identities = 82/315 (26%), Positives = 137/315 (43%), Gaps = 19/315 (6%)
Query: 239 LKMSNNYRLELASSANNLFSQSLKYIDISY---CNILQPNLKGFPSLRKAILNHNMVRYL 295
L + +N+ EL FSQ L ++ + + + + +G L++ IL+ N + YL
Sbjct: 66 LSLRHNHITELERDQFASFSQ-LTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYL 124
Query: 296 ESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLT 355
+ F L+ LDLS N ++SL + F GL+ L+ L L N + IP + SL
Sbjct: 125 PNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLE 184
Query: 356 QLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYI 412
L LS N L+R G + + L + +L I L S+ L L N +S +
Sbjct: 185 FLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNL 244
Query: 413 PDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYL 470
+ + TL+ L+L N I +I+ F + L L + N+ + +S L
Sbjct: 245 TCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSL-DSKILNSLRSL 303
Query: 471 ERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANVNTQTWLEACY--- 527
+ LS N+W C + ++ + E S ++C+SP + + L+A +
Sbjct: 304 TTVGLSGNLWECSA---RICALASWLGSFQGRWEHS--ILCHSPDHTQGEDILDAVHGFQ 358
Query: 528 FTWN-PTEKTANADT 541
WN T T A T
Sbjct: 359 LCWNLSTTVTVMATT 373
Score = 52.8 bits (121), Expect = 4e-06
Identities = 74/302 (24%), Positives = 126/302 (41%), Gaps = 28/302 (9%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C +K C +G +PN L++ +N T+ + + L L + NQ
Sbjct: 37 KCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQ 96
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ + ++A L L+ L LS N + PN +L+ LDLSFN+ ++
Sbjct: 97 ISTVKEDAFQGLYKLKELILSSNK----IFYLPNTTFTQLINLQNLDLSFNQLSSL---- 148
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
+ EL L L H NS+ P+ + R L+ R+++L + L
Sbjct: 149 HPELFY--GLRKLQTLHLRSNSLR-TIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGL- 204
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ EL L HN+ LT + ++ RL SS + LF Q K +++ C +
Sbjct: 205 IKLREL-HLEHNQ------LTKINFAHFLRL---SSLHTLFLQWNKISNLT-CGMEWT-- 251
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+ +L K L N ++ ++ F L+ L + NN + SL L+ L + LS
Sbjct: 252 --WGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLS 309
Query: 337 WN 338
N
Sbjct: 310 GN 311
>AB007876-1|BAA24846.2| 529|Homo sapiens KIAA0416 protein.
Length = 529
Score = 76.2 bits (179), Expect = 4e-13
Identities = 60/197 (30%), Positives = 101/197 (51%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L HN + LE + FA+ ++L +L L +N I++++ D F+GL LK L LS N+I +P
Sbjct: 81 LRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNT 140
Query: 347 SLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ ++ +L L LS N LS + + L + S L TI +S+ LD
Sbjct: 141 TFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLD 200
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
LS N L + + + +K L+L +N+++ IN F L+ L +L + N+ + +
Sbjct: 201 LSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCG 260
Query: 462 SFFDSNPYLERLDLSDN 478
+ LE+LDL+ N
Sbjct: 261 MEWTWGT-LEKLDLTGN 276
Score = 74.5 bits (175), Expect = 1e-12
Identities = 82/315 (26%), Positives = 137/315 (43%), Gaps = 19/315 (6%)
Query: 239 LKMSNNYRLELASSANNLFSQSLKYIDISY---CNILQPNLKGFPSLRKAILNHNMVRYL 295
L + +N+ EL FSQ L ++ + + + + +G L++ IL+ N + YL
Sbjct: 79 LSLRHNHITELERDQFASFSQ-LTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYL 137
Query: 296 ESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLT 355
+ F L+ LDLS N ++SL + F GL+ L+ L L N + IP + SL
Sbjct: 138 PNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLE 197
Query: 356 QLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYI 412
L LS N L+R G + + L + +L I L S+ L L N +S +
Sbjct: 198 FLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNL 257
Query: 413 PDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYL 470
+ + TL+ L+L N I +I+ F + L L + N+ + +S L
Sbjct: 258 TCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSL-DSKILNSLRSL 316
Query: 471 ERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANVNTQTWLEACY--- 527
+ LS N+W C + ++ + E S ++C+SP + + L+A +
Sbjct: 317 TTVGLSGNLWECSA---RICALASWLGSFQGRWEHS--ILCHSPDHTQGEDILDAVHGFQ 371
Query: 528 FTWN-PTEKTANADT 541
WN T T A T
Sbjct: 372 LCWNLSTTVTVMATT 386
Score = 52.8 bits (121), Expect = 4e-06
Identities = 74/302 (24%), Positives = 126/302 (41%), Gaps = 28/302 (9%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQ 96
+C +K C +G +PN L++ +N T+ + + L L + NQ
Sbjct: 50 KCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQ 109
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ + ++A L L+ L LS N + PN +L+ LDLSFN+ ++
Sbjct: 110 ISTVKEDAFQGLYKLKELILSSNK----IFYLPNTTFTQLINLQNLDLSFNQLSSL---- 161
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
+ EL L L H NS+ P+ + R L+ R+++L + L
Sbjct: 162 HPELFY--GLRKLQTLHLRSNSLR-TIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGL- 217
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ EL L HN+ LT + ++ RL SS + LF Q K +++ C +
Sbjct: 218 IKLREL-HLEHNQ------LTKINFAHFLRL---SSLHTLFLQWNKISNLT-CGMEWT-- 264
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+ +L K L N ++ ++ F L+ L + NN + SL L+ L + LS
Sbjct: 265 --WGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLS 322
Query: 337 WN 338
N
Sbjct: 323 GN 324
>BC011057-1|AAH11057.2| 620|Homo sapiens leucine rich repeat and Ig
domain containing 1 protein.
Length = 620
Score = 74.9 bits (176), Expect = 9e-13
Identities = 69/279 (24%), Positives = 130/279 (46%), Gaps = 10/279 (3%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDI 266
I + R L + + +LN +E P L L+++ N + A NNLF+ +
Sbjct: 69 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRS 128
Query: 267 SYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+ ++ + G +L K ++ N + L F + L+ L++ +N++ + + F
Sbjct: 129 NRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFS 188
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR---NYLSRVGHLRSMSVTILDMSS 382
GL L+ L L + IP ++L + L L+L N + R + +L++S
Sbjct: 189 GLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISH 248
Query: 383 CE-LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTF 439
L+T+ + L GL ++ L ++ L+ +P + L++LNL+YN IS+I
Sbjct: 249 WPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSML 307
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L RL + +VG + ++ +F N YL L++S N
Sbjct: 308 HELLRLQEIQLVGGQLAVVEPYAFRGLN-YLRVLNVSGN 345
Score = 73.7 bits (173), Expect = 2e-12
Identities = 81/335 (24%), Positives = 140/335 (41%), Gaps = 14/335 (4%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSN 95
C C+ + C R+ +P G+ + L++ N T + + +L L+++ N
Sbjct: 46 CECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNEN 105
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + A NL L L L N L L P V ++L LD+S NK + +
Sbjct: 106 IVSAVEPGAFNNLFNLRTLGLRSNR----LKLIPLGVFTGLSNLTKLDISENKIVILLDY 161
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
Q+L SLE + D+ + H SGL ++ L L L I S L L
Sbjct: 162 MFQDLYNLKSLE--VGDNDLVYISH--RAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGL 217
Query: 216 FVSNCELTSLNHNELMFLPSLTHLKM--SNNYRLELASSANNLFSQSLKYIDISYCNILQ 273
V ++N L LK+ +++ + N L+ +L + I++CN+
Sbjct: 218 IVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTA 277
Query: 274 -PNL--KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L + LR L++N + +E + L+ + L +A + FRGL L
Sbjct: 278 VPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYL 337
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L++S N++ + E + +L L L N L+
Sbjct: 338 RVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLA 372
>AY358284-1|AAQ88651.1| 620|Homo sapiens QVSK201 protein.
Length = 620
Score = 74.9 bits (176), Expect = 9e-13
Identities = 69/279 (24%), Positives = 130/279 (46%), Gaps = 10/279 (3%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDI 266
I + R L + + +LN +E P L L+++ N + A NNLF+ +
Sbjct: 69 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRS 128
Query: 267 SYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+ ++ + G +L K ++ N + L F + L+ L++ +N++ + + F
Sbjct: 129 NRLKLIPLGVFTGLSNLTKQDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFS 188
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR---NYLSRVGHLRSMSVTILDMSS 382
GL L+ L L + IP ++L + L L+L N + R + +L++S
Sbjct: 189 GLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISH 248
Query: 383 CE-LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTF 439
L+T+ + L GL ++ L ++ L+ +P + L++LNL+YN IS+I
Sbjct: 249 WPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSML 307
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L RL + +VG + ++ +F N YL L++S N
Sbjct: 308 HELLRLQEIQLVGGQLAVVEPYAFRGLN-YLRVLNVSGN 345
Score = 70.9 bits (166), Expect = 2e-11
Identities = 80/335 (23%), Positives = 139/335 (41%), Gaps = 14/335 (4%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSN 95
C C+ + C R+ +P G+ + L++ N T + + +L L+++ N
Sbjct: 46 CECSAQDRAVLCHRKCFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNEN 105
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + A NL L L L N L L P V ++L D+S NK + +
Sbjct: 106 IVSAVEPGAFNNLFNLRTLGLRSNR----LKLIPLGVFTGLSNLTKQDISENKIVILLDY 161
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
Q+L SLE + D+ + H SGL ++ L L L I S L L
Sbjct: 162 MFQDLYNLKSLE--VGDNDLVYISH--RAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGL 217
Query: 216 FVSNCELTSLNHNELMFLPSLTHLKM--SNNYRLELASSANNLFSQSLKYIDISYCNILQ 273
V ++N L LK+ +++ + N L+ +L + I++CN+
Sbjct: 218 IVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTA 277
Query: 274 -PNL--KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L + LR L++N + +E + L+ + L +A + FRGL L
Sbjct: 278 VPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYL 337
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L++S N++ + E + +L L L N L+
Sbjct: 338 RVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLA 372
>AY324320-1|AAQ97216.1| 620|Homo sapiens leucine-rich repeat
neuronal 6A protein.
Length = 620
Score = 74.9 bits (176), Expect = 9e-13
Identities = 69/279 (24%), Positives = 130/279 (46%), Gaps = 10/279 (3%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDI 266
I + R L + + +LN +E P L L+++ N + A NNLF+ +
Sbjct: 69 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRS 128
Query: 267 SYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+ ++ + G +L K ++ N + L F + L+ L++ +N++ + + F
Sbjct: 129 NRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFS 188
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR---NYLSRVGHLRSMSVTILDMSS 382
GL L+ L L + IP ++L + L L+L N + R + +L++S
Sbjct: 189 GLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISH 248
Query: 383 CE-LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTF 439
L+T+ + L GL ++ L ++ L+ +P + L++LNL+YN IS+I
Sbjct: 249 WPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSML 307
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L RL + +VG + ++ +F N YL L++S N
Sbjct: 308 HELLRLQEIQLVGGQLAVVEPYAFRGLN-YLRVLNVSGN 345
Score = 73.7 bits (173), Expect = 2e-12
Identities = 81/335 (24%), Positives = 140/335 (41%), Gaps = 14/335 (4%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSN 95
C C+ + C R+ +P G+ + L++ N T + + +L L+++ N
Sbjct: 46 CECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNEN 105
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + A NL L L L N L L P V ++L LD+S NK + +
Sbjct: 106 IVSAVEPGAFNNLFNLRTLGLRSNR----LKLIPLGVFTGLSNLTKLDISENKIVILLDY 161
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
Q+L SLE + D+ + H SGL ++ L L L I S L L
Sbjct: 162 MFQDLYNLKSLE--VGDNDLVYISH--RAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGL 217
Query: 216 FVSNCELTSLNHNELMFLPSLTHLKM--SNNYRLELASSANNLFSQSLKYIDISYCNILQ 273
V ++N L LK+ +++ + N L+ +L + I++CN+
Sbjct: 218 IVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTA 277
Query: 274 -PNL--KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L + LR L++N + +E + L+ + L +A + FRGL L
Sbjct: 278 VPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYL 337
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L++S N++ + E + +L L L N L+
Sbjct: 338 RVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLA 372
>AL834260-1|CAD38935.1| 577|Homo sapiens hypothetical protein
protein.
Length = 577
Score = 74.9 bits (176), Expect = 9e-13
Identities = 69/279 (24%), Positives = 130/279 (46%), Gaps = 10/279 (3%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDI 266
I + R L + + +LN +E P L L+++ N + A NNLF+ +
Sbjct: 26 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRS 85
Query: 267 SYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+ ++ + G +L K ++ N + L F + L+ L++ +N++ + + F
Sbjct: 86 NRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFS 145
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR---NYLSRVGHLRSMSVTILDMSS 382
GL L+ L L + IP ++L + L L+L N + R + +L++S
Sbjct: 146 GLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISH 205
Query: 383 CE-LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTF 439
L+T+ + L GL ++ L ++ L+ +P + L++LNL+YN IS+I
Sbjct: 206 WPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSML 264
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L RL + +VG + ++ +F N YL L++S N
Sbjct: 265 HELLRLQEIQLVGGQLAVVEPYAFRGLN-YLRVLNVSGN 302
Score = 73.7 bits (173), Expect = 2e-12
Identities = 81/335 (24%), Positives = 140/335 (41%), Gaps = 14/335 (4%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSN 95
C C+ + C R+ +P G+ + L++ N T + + +L L+++ N
Sbjct: 3 CECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNEN 62
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + A NL L L L N L L P V ++L LD+S NK + +
Sbjct: 63 IVSAVEPGAFNNLFNLRTLGLRSNR----LKLIPLGVFTGLSNLTKLDISENKIVILLDY 118
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
Q+L SLE + D+ + H SGL ++ L L L I S L L
Sbjct: 119 MFQDLYNLKSLE--VGDNDLVYISH--RAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGL 174
Query: 216 FVSNCELTSLNHNELMFLPSLTHLKM--SNNYRLELASSANNLFSQSLKYIDISYCNILQ 273
V ++N L LK+ +++ + N L+ +L + I++CN+
Sbjct: 175 IVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTA 234
Query: 274 -PNL--KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
P L + LR L++N + +E + L+ + L +A + FRGL L
Sbjct: 235 VPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYL 294
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L++S N++ + E + +L L L N L+
Sbjct: 295 RVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLA 329
>AB016816-1|BAA74737.1| 1052|Homo sapiens MASL1 protein.
Length = 1052
Score = 74.9 bits (176), Expect = 9e-13
Identities = 90/309 (29%), Positives = 143/309 (46%), Gaps = 26/309 (8%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNI---SNNEFTKFPESLSRL-HNLVNLDISSNQLKGLP 101
++ GL ++P GLG + L + N F + P +++ L H+L LD+S N+L L
Sbjct: 68 LNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALG 127
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
+ L L LNLS N L P L HL+ LD+SFN+ + + L
Sbjct: 128 AEVVSALRELRKLNLSHNQ----LPALPAQ-LGALAHLEELDVSFNRLAHLPD----SLS 178
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSN 219
L TL +DH ++ + + L L+ + L ++ N L + IS+ +L+ L++S
Sbjct: 179 CLSRLRTLDVDHNQLTAFPRQ--LLQLVALEELDVSSNRLRGLPEDISALRALKILWLSG 236
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ---PNL 276
EL +L L SL L + NN L + + L Q LK +++S N+ + L
Sbjct: 237 AELGTLPAG-FCELASLESLMLDNNGLQALPAQFSCL--QRLKMLNLS-SNLFEEFPAAL 292
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
L + L+ N + + S + L L L NN I L D+ L L+ L L
Sbjct: 293 LPLAGLEELYLSRNQLTSVPS-LISGLGRLLTLWLDNNRIRYLP-DSIVELTGLEELVLQ 350
Query: 337 WNEIAVIPE 345
N+IAV+P+
Sbjct: 351 GNQIAVLPD 359
Score = 55.6 bits (128), Expect = 6e-07
Identities = 99/354 (27%), Positives = 156/354 (44%), Gaps = 61/354 (17%)
Query: 82 SRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKI 141
+ L ++ L++ +N L+ +P+ L +L VL L RN F P V HL
Sbjct: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARL----PPAVAELGHHLTE 115
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
LD+S N+ +G A +R L L L H ++ ++ + L L ++ L ++FN L
Sbjct: 116 LDVSHNRLTALG--AEVVSALR-ELRKLNLSHNQLPALPAQ--LGALAHLEELDVSFNRL 170
Query: 202 LRIQNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ 259
+ + +S S LR+L V + +LT+ +L+ L +L L +S+N L + L +
Sbjct: 171 AHLPDSLSCLSRLRTLDVDHNQLTAFPR-QLLQLVALEELDVSSNRLRGLPEDISAL--R 227
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
+LK + +S L P+ F LE L L NN + +L
Sbjct: 228 ALKILWLSGAE-----LGTLPA-----------------GFCELASLESLMLDNNGLQAL 265
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD 379
F L+ LK L+LS N P +LL + L +L LSRN L+ V L
Sbjct: 266 PAQ-FSCLQRLKMLNLSSNLFEEFPA-ALLPLAGLEELYLSRNQLTSVPSL--------- 314
Query: 380 MSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT-LKYLNLNYNRIS 432
+ GL ++ L L N + Y+PDSI T L+ L L N+I+
Sbjct: 315 -------------ISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIA 355
Score = 54.8 bits (126), Expect = 1e-06
Identities = 57/203 (28%), Positives = 97/203 (47%), Gaps = 8/203 (3%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
SLR +L N L L LD+S+N + +L + L+ L+ L+LS N++
Sbjct: 88 SLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQL 147
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRV-GHLRSMS-VTILDMSSCELNTIGKDSLEGLQS 398
+P L + L +L +S N L+ + L +S + LD+ +L + L+ L +
Sbjct: 148 PALPA-QLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQ-LVA 205
Query: 399 IVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTM 457
+ ELD+S N L +P+ IS+ LK L L+ + ++ F L L SL + N
Sbjct: 206 LEELDVSSNRLRGLPEDISALRALKILWLSGAELGTL-PAGFCELASLESLMLDNNGLQA 264
Query: 458 IWRRSFFDSNPYLERLDLSDNMW 480
+ + F L+ L+LS N++
Sbjct: 265 L--PAQFSCLQRLKMLNLSSNLF 285
Score = 52.4 bits (120), Expect = 6e-06
Identities = 74/317 (23%), Positives = 138/317 (43%), Gaps = 24/317 (7%)
Query: 44 TDIDCSRRGLT----DIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKG 99
T++D S LT ++ + L ++ KLN+S+N+ P L L +L LD+S N+L
Sbjct: 114 TELDVSHNRLTALGAEVVSALR-ELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAH 172
Query: 100 LPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQE 159
LPD +L L+ L L++ N ++ P LL L+ LD+S N+ + + ++
Sbjct: 173 LPD-SLSCLSRLRTLDVDHNQLTAF----PRQ-LLQLVALEELDVSSNRLRGL----PED 222
Query: 160 LLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSN 219
+ +L+ L L E+ ++ + L ++ L L+ N L + S L+ L + N
Sbjct: 223 ISALRALKILWLSGAELGTL--PAGFCELASLESLMLDNNGLQALPAQF-SCLQRLKMLN 279
Query: 220 CELTSLNHNELMFLP--SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLK 277
LP L L +S N + S + L ++D + L ++
Sbjct: 280 LSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIV 339
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT-FRGLKMLK--HLD 334
L + +L N + L + F + + + +N + Y+ +G+ + +
Sbjct: 340 ELTGLEELVLQGNQIAVLPDH-FGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKE 398
Query: 335 LSWNEIAVIPEDSLLEM 351
L+ ++ AV P LL M
Sbjct: 399 LAHSQPAVQPRLKLLLM 415
>BC131897-1|AAI31898.1| 420|Homo sapiens LRRC4B protein protein.
Length = 420
Score = 74.5 bits (175), Expect = 1e-12
Identities = 62/204 (30%), Positives = 94/204 (46%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N+VR +E AF L L+L +N + ++ F L L+ L L N I IP
Sbjct: 117 LSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L Y+S +++ L++ C L I +L L + EL
Sbjct: 177 AFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDI--PNLTALVRLEEL 234
Query: 403 DLSQNLLSYI-PDSISSNT-LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
+LS N L I P S T L+ L L + ++++I F L L L++ N M
Sbjct: 235 ELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNL-MSLP 293
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F LER+ L+ N W C+C
Sbjct: 294 HDLFTPLHRLERVHLNHNPWHCNC 317
Score = 62.1 bits (144), Expect = 7e-09
Identities = 66/261 (25%), Positives = 113/261 (43%), Gaps = 17/261 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ + + C+RR L ++P + + LN+ N ++ L +L L +S N
Sbjct: 61 CSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKN 120
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
++ + A L +L L L FD+ L P + L+ L L N +++ +
Sbjct: 121 LVRKIEVGAFNGLPSLNTLEL----FDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS-SSLRS 214
A + PSL L L + + GL+N+R L L L I NL + L
Sbjct: 177 AFNRV---PSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEE 233
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNIL 272
L +S L + L SL L + + ++A+ N F +SL+ +++S+ N++
Sbjct: 234 LELSGNRLDLIRPGSFQGLTSLRKLWLMH---AQVATIERNAFDDLKSLEELNLSHNNLM 290
Query: 273 Q-PNLKGFP--SLRKAILNHN 290
P+ P L + LNHN
Sbjct: 291 SLPHDLFTPLHRLERVHLNHN 311
Score = 61.3 bits (142), Expect = 1e-08
Identities = 64/224 (28%), Positives = 104/224 (46%), Gaps = 8/224 (3%)
Query: 119 NYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINS 178
N ++ + + D HL+IL LS N + + A L PSL TL L + +
Sbjct: 92 NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGL---PSLNTLELFDNRLTT 148
Query: 179 IHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNC-ELTSLNHNELMFLPSLT 237
+ ++ L +R L L NP+ I + + + SL + EL L + L
Sbjct: 149 VPTQA-FEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLV 207
Query: 238 HLKMSNNYRLELASSANNLFSQSLKYIDIS--YCNILQP-NLKGFPSLRKAILNHNMVRY 294
+L+ N L N L+ +++S ++++P + +G SLRK L H V
Sbjct: 208 NLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVAT 267
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+E NAF + LE L+LS+NN+ SL +D F L L+ + L+ N
Sbjct: 268 IERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
Score = 58.8 bits (136), Expect = 7e-08
Identities = 52/162 (32%), Positives = 77/162 (47%), Gaps = 8/162 (4%)
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
YL+L N I +R DTF+ L+ L+ L LS N + I + +PSL L+L N L+ V
Sbjct: 90 YLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTV 149
Query: 368 ---GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQ-NLLSYIPDSISSN--TL 421
+ L + + + +I + + S+ LDL + L YI ++ L
Sbjct: 150 PTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNL 209
Query: 422 KYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSF 463
+YLNL + I NLT L RL L + GNR +I SF
Sbjct: 210 RYLNLGMCNLKDIPNLT--ALVRLEELELSGNRLDLIRPGSF 249
>BC032460-1|AAH32460.1| 634|Homo sapiens Unknown (protein for
IMAGE:5200456) protein.
Length = 634
Score = 74.5 bits (175), Expect = 1e-12
Identities = 62/204 (30%), Positives = 94/204 (46%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N+VR +E AF L L+L +N + ++ F L L+ L L N I IP
Sbjct: 117 LSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L Y+S +++ L++ C L I +L L + EL
Sbjct: 177 AFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDI--PNLTALVRLEEL 234
Query: 403 DLSQNLLSYI-PDSISSNT-LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
+LS N L I P S T L+ L L + ++++I F L L L++ N M
Sbjct: 235 ELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNL-MSLP 293
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F LER+ L+ N W C+C
Sbjct: 294 HDLFTPLHRLERVHLNHNPWHCNC 317
Score = 62.1 bits (144), Expect = 7e-09
Identities = 66/261 (25%), Positives = 113/261 (43%), Gaps = 17/261 (6%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSN 95
C C+ + + C+RR L ++P + + LN+ N ++ L +L L +S N
Sbjct: 61 CSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKN 120
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
++ + A L +L L L FD+ L P + L+ L L N +++ +
Sbjct: 121 LVRKIEVGAFNGLPSLNTLEL----FDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS-SSLRS 214
A + PSL L L + + GL+N+R L L L I NL + L
Sbjct: 177 AFNRV---PSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEE 233
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNIL 272
L +S L + L SL L + + ++A+ N F +SL+ +++S+ N++
Sbjct: 234 LELSGNRLDLIRPGSFQGLTSLRKLWLMH---AQVATIERNAFDDLKSLEELNLSHNNLM 290
Query: 273 Q-PNLKGFP--SLRKAILNHN 290
P+ P L + LNHN
Sbjct: 291 SLPHDLFTPLHRLERVHLNHN 311
Score = 61.3 bits (142), Expect = 1e-08
Identities = 64/224 (28%), Positives = 104/224 (46%), Gaps = 8/224 (3%)
Query: 119 NYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINS 178
N ++ + + D HL+IL LS N + + A L PSL TL L + +
Sbjct: 92 NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGL---PSLNTLELFDNRLTT 148
Query: 179 IHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNC-ELTSLNHNELMFLPSLT 237
+ ++ L +R L L NP+ I + + + SL + EL L + L
Sbjct: 149 VPTQA-FEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLV 207
Query: 238 HLKMSNNYRLELASSANNLFSQSLKYIDIS--YCNILQP-NLKGFPSLRKAILNHNMVRY 294
+L+ N L N L+ +++S ++++P + +G SLRK L H V
Sbjct: 208 NLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVAT 267
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+E NAF + LE L+LS+NN+ SL +D F L L+ + L+ N
Sbjct: 268 IERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
Score = 58.8 bits (136), Expect = 7e-08
Identities = 52/162 (32%), Positives = 77/162 (47%), Gaps = 8/162 (4%)
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
YL+L N I +R DTF+ L+ L+ L LS N + I + +PSL L+L N L+ V
Sbjct: 90 YLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTV 149
Query: 368 ---GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQ-NLLSYIPDSISSN--TL 421
+ L + + + +I + + S+ LDL + L YI ++ L
Sbjct: 150 PTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNL 209
Query: 422 KYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSF 463
+YLNL + I NLT L RL L + GNR +I SF
Sbjct: 210 RYLNLGMCNLKDIPNLT--ALVRLEELELSGNRLDLIRPGSF 249
>BC101077-1|AAI01078.1| 1041|Homo sapiens toll-like receptor 8
protein.
Length = 1041
Score = 73.7 bits (173), Expect = 2e-12
Identities = 120/501 (23%), Positives = 215/501 (42%), Gaps = 67/501 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL--- 97
D +CS R L ++P +G VT+L++S+N T ES L NL ++++ N
Sbjct: 43 DSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH 102
Query: 98 ----KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
G+ N L N+T LNL +N + L N + + +LS + +
Sbjct: 103 QNGNPGIQSNGL-NITDGAFLNL-KNLRELLLEDNQLPQIPSGLPESLTELSLIQ-NNIY 159
Query: 154 NLANQELLIRPSLETLILD-HCEINSIHGRSPLSG-----LINIRVLKLNFNPLLRIQNL 207
N+ + + +L+ L L +C N + ++ + L N+ +L L+FN L +
Sbjct: 160 NITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPK 219
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN-----------YRLELASSAN-N 255
+ SSLR LF+SN ++ ++ + L +LT L +S N + +S N +
Sbjct: 220 LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINID 279
Query: 256 LFS----QSLKYIDISYCNILQPN---LKGFPSLRKAILNHN-MVRYLESNAFANN-TEL 306
F+ L+Y+++S ++ + N K P L+ L N +V + S AF L
Sbjct: 280 RFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRL 339
Query: 307 EYLDLSNNNIASLRYD------TFRGLKMLKHLDLSWNEIAVIPEDS---LLEMPSLTQL 357
E LDLS N I F L L+ L L + ED L+++P+L+ +
Sbjct: 340 EILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTI 399
Query: 358 KLSRNYLSRVGH--LRSMS-VTILDMSSCELNTIGKDSLEGL--------------QSIV 400
L N++ ++ ++ S + I+ +S ++ + KD+ + +
Sbjct: 400 NLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF 459
Query: 401 ELDLSQNLLSYIPDSISSNTLKY---LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTM 457
E D N + I Y L+L+ N I I F L + L++ N
Sbjct: 460 EFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 519
Query: 458 IWRRSFFDSNPYLERLDLSDN 478
+ + F + P+++ LDL++N
Sbjct: 520 VLSGTEFSAIPHVKYLDLTNN 540
Score = 64.1 bits (149), Expect = 2e-09
Identities = 131/476 (27%), Positives = 196/476 (41%), Gaps = 70/476 (14%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLK------ 98
+ S L+ +P L + KL +SN + E L NL LD+S N +
Sbjct: 206 LSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPF 265
Query: 99 -------GLPDN----ALYNLTALEVLNLS----RNYFDSWLNLNPNDVLLPATHLKILD 143
G N A NLT L LNLS R +W P HLK+LD
Sbjct: 266 PCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMP--------HLKVLD 317
Query: 144 LSFNKFQTMGNLANQELL-IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
L FN +G +A+ L + P LE L L N I G P INI NF+ LL
Sbjct: 318 LEFNYL--VGEIASGAFLTMLPRLEILDLS---FNYIKGSYPQH--INI---SRNFSKLL 367
Query: 203 RIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLK 262
++ L LR EL + LM LP+L+ + + N+ ++ FS +L+
Sbjct: 368 SLRAL---HLRGYVFQ--ELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFS-NLE 421
Query: 263 YIDISYCNILQPNLKGFPSLRKAILNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRY 321
I +S N + P +K R++ N + R++ +T+ E+ SN +
Sbjct: 422 IIYLSE-NRISPLVK---DTRQSYANSSSFQRHIRKR---RSTDFEFDPHSNFYHFTRPL 474
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMS----VTI 377
+ K LDLS N I I + +P + L LS N ++V S V
Sbjct: 475 IKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKY 534
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNL-------LSYIPDSISSNT-LKYLNLNYN 429
LD+++ L+ +L L + LDLS N +++ + I + T LK LNL++N
Sbjct: 535 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHN 594
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
I ++ + L L GNR ++W D N Y+ N+ R D S
Sbjct: 595 NIYTLTDKYNLESKSLVELVFSGNRLDILWND---DDNRYISIFKGLKNLTRLDLS 647
Score = 63.7 bits (148), Expect = 2e-09
Identities = 100/415 (24%), Positives = 189/415 (45%), Gaps = 36/415 (8%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+ L L L++SS L+ + N+ L+VL+L NY + +LP L
Sbjct: 282 AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP--RL 339
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ILDLSFN + G+ Q + I + L+ + ++H L G + + + +F
Sbjct: 340 EILDLSFNYIK--GSYP-QHINISRNFSKLL----SLRALH----LRGYVFQELREDDFQ 388
Query: 200 PLLRIQNLISSSLRSLFVSNCELT---SLNHNELMFLPSLTHLKMSNNYRLELASSAN-N 255
PL+++ NL + +L F+ + + ++ E+++L + + R A+S++
Sbjct: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 448
Query: 256 LFSQSLKYIDI------SYCNILQPNLKG-FPSLRKAI-LNHNMVRYLESNAFANNTELE 307
+ + D ++ + +P +K + KA+ L+ N + ++ N F N ++
Sbjct: 449 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA 508
Query: 308 YLDLSNNNIASLRYDT-FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN-YLS 365
L+LS N+ A + T F + +K+LDL+ N + +L E+ L L LS N +
Sbjct: 509 CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYF 568
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL- 424
R+ + I + ++ ++ + +++ L L+ S++L+ + S N L L
Sbjct: 569 RIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE-SKSLVELV---FSGNRLDILW 624
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N + NR SI F L LT L + NR I +F + L L ++DNM
Sbjct: 625 NDDDNRYISI----FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM 675
Score = 62.9 bits (146), Expect = 4e-09
Identities = 115/446 (25%), Positives = 184/446 (41%), Gaps = 41/446 (9%)
Query: 63 QVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKG-LPDNA-LYNLTALEVLNLSRN 119
Q+ LN+S+ K + + +L LD+ N L G + A L L LE+L+LS N
Sbjct: 288 QLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN 347
Query: 120 Y----FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
Y + +N++ N L + L+ L L FQ + Q L+ P+L T+ L
Sbjct: 348 YIKGSYPQHINISRNFSKLLS--LRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINF 405
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
I I + N+ ++ L+ N RI L+ + +S S+ +
Sbjct: 406 IKQIDFKL-FQNFSNLEIIYLSEN---RISPLVKDTRQSYANSSSFQRHIRKRRSTDFEF 461
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI--LQPN-LKGFPSLRKAILNHNM- 291
H SN Y + K +D+S +I + PN + P + L+ N
Sbjct: 462 DPH---SNFYHFTRPLIKPQCAAYG-KALDLSLNSIFFIGPNQFENLPDIACLNLSANSN 517
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE----IAVIPE-- 345
+ L F+ ++YLDL+NN + L L+ LDLS+N IA +
Sbjct: 518 AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHL 577
Query: 346 DSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDS-------LEG 395
+ + +L L LS N + + +L S S+ L S L+ + D +G
Sbjct: 578 EFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKG 637
Query: 396 LQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
L+++ LDLS N L +IP+ N +L L++N N + N RL L + G
Sbjct: 638 LKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRG 697
Query: 453 NRFTMIWRRSFFDSNPYLERLDLSDN 478
N+ + S D L L LS N
Sbjct: 698 NKLLFL-TDSLSDFTSSLRTLLLSHN 722
Score = 60.5 bits (140), Expect = 2e-08
Identities = 87/303 (28%), Positives = 124/303 (40%), Gaps = 24/303 (7%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + N NL + LNLS N L+ + H+K LDL+ N+
Sbjct: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAI---PHVKYLDLTNNRL 542
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRIQ-- 205
A EL L+ H I + H + N++VL L+ N + +
Sbjct: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
Query: 206 -NLISSSLRSLFVSNCELTSL-NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
NL S SL L S L L N ++ ++ LK N RL+L S N L K+
Sbjct: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLK--NLTRLDL--SLNRL-----KH 653
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
I N NL SL + +N NM+++ LE LDL N + L
Sbjct: 654 IP----NEAFLNLPA--SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL 707
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSC 383
L+ L LS N I+ +P L E+ SL L LS N L + + T +S
Sbjct: 708 SDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 767
Query: 384 ELN 386
EL+
Sbjct: 768 ELH 770
Score = 55.6 bits (128), Expect = 6e-07
Identities = 74/265 (27%), Positives = 122/265 (46%), Gaps = 21/265 (7%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN--YFDSW 124
L+ ++N S + ++ LD+++N+L +AL L+ LEVL+LS N YF
Sbjct: 512 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA 571
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEI----NSIH 180
+ + + T+LK+L+LS N T+ + N E SL L+ + N
Sbjct: 572 GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE---SKSLVELVFSGNRLDILWNDDD 628
Query: 181 GR--SPLSGLINIRVLKLNFNPLLRIQN----LISSSLRSLFVSNCELTSLNHNELMFLP 234
R S GL N+ L L+ N L I N + +SL L +++ L N L P
Sbjct: 629 NRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFP 688
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PN--LKGFPSLRKAILNHNM 291
L L + N L L S ++ F+ SL+ + +S+ I P+ L SL+ L+ N+
Sbjct: 689 RLELLDLRGNKLLFLTDSLSD-FTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 747
Query: 292 VRYLESNAF--ANNTELEYLDLSNN 314
++ + +A T+L L+L N
Sbjct: 748 LKTINKSALETKTTTKLSMLELHGN 772
Score = 42.3 bits (95), Expect = 0.006
Identities = 74/288 (25%), Positives = 127/288 (44%), Gaps = 21/288 (7%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
A + K LDLS N +G + L P + L L + + S + +++ L
Sbjct: 480 AAYGKALDLSLNSIFFIGPNQFENL---PDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 536
Query: 196 LNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLTH-LKMSNNY-RLELAS- 251
L N L N +S+L L S+ E+ L++N F + +TH L+ N+ L++ +
Sbjct: 537 LT-NNRLDFDN--ASALTEL--SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNL 591
Query: 252 SANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL 311
S NN+++ + KY ++ ++++ G + + N + RY+ + F L LDL
Sbjct: 592 SHNNIYTLTDKY-NLESKSLVELVFSG--NRLDILWNDDDNRYI--SIFKGLKNLTRLDL 646
Query: 312 SNNNIASLRYDTFRGLKM-LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL 370
S N + + + F L L L ++ N + L + P L L L N L +
Sbjct: 647 SLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDS 706
Query: 371 RS---MSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS 415
S S+ L +S ++ + L + S+ LDLS NLL I S
Sbjct: 707 LSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 754
>BC101076-1|AAI01077.1| 1041|Homo sapiens toll-like receptor 8
protein.
Length = 1041
Score = 73.7 bits (173), Expect = 2e-12
Identities = 120/501 (23%), Positives = 215/501 (42%), Gaps = 67/501 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL--- 97
D +CS R L ++P +G VT+L++S+N T ES L NL ++++ N
Sbjct: 43 DSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH 102
Query: 98 ----KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
G+ N L N+T LNL +N + L N + + +LS + +
Sbjct: 103 QNGNPGIQSNGL-NITDGAFLNL-KNLRELLLEDNQLPQIPSGLPESLTELSLIQ-NNIY 159
Query: 154 NLANQELLIRPSLETLILD-HCEINSIHGRSPLSG-----LINIRVLKLNFNPLLRIQNL 207
N+ + + +L+ L L +C N + ++ + L N+ +L L+FN L +
Sbjct: 160 NITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPK 219
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN-----------YRLELASSAN-N 255
+ SSLR LF+SN ++ ++ + L +LT L +S N + +S N +
Sbjct: 220 LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINID 279
Query: 256 LFS----QSLKYIDISYCNILQPN---LKGFPSLRKAILNHN-MVRYLESNAFANN-TEL 306
F+ L+Y+++S ++ + N K P L+ L N +V + S AF L
Sbjct: 280 RFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRL 339
Query: 307 EYLDLSNNNIASLRYD------TFRGLKMLKHLDLSWNEIAVIPEDS---LLEMPSLTQL 357
E LDLS N I F L L+ L L + ED L+++P+L+ +
Sbjct: 340 EILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTI 399
Query: 358 KLSRNYLSRVGH--LRSMS-VTILDMSSCELNTIGKDSLEGL--------------QSIV 400
L N++ ++ ++ S + I+ +S ++ + KD+ + +
Sbjct: 400 NLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF 459
Query: 401 ELDLSQNLLSYIPDSISSNTLKY---LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTM 457
E D N + I Y L+L+ N I I F L + L++ N
Sbjct: 460 EFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 519
Query: 458 IWRRSFFDSNPYLERLDLSDN 478
+ + F + P+++ LDL++N
Sbjct: 520 VLSGTEFSAIPHVKYLDLTNN 540
Score = 64.1 bits (149), Expect = 2e-09
Identities = 131/476 (27%), Positives = 196/476 (41%), Gaps = 70/476 (14%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLK------ 98
+ S L+ +P L + KL +SN + E L NL LD+S N +
Sbjct: 206 LSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPF 265
Query: 99 -------GLPDN----ALYNLTALEVLNLS----RNYFDSWLNLNPNDVLLPATHLKILD 143
G N A NLT L LNLS R +W P HLK+LD
Sbjct: 266 PCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMP--------HLKVLD 317
Query: 144 LSFNKFQTMGNLANQELL-IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
L FN +G +A+ L + P LE L L N I G P INI NF+ LL
Sbjct: 318 LEFNYL--VGEIASGAFLTMLPRLEILDLS---FNYIKGSYPQH--INI---SRNFSKLL 367
Query: 203 RIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLK 262
++ L LR EL + LM LP+L+ + + N+ ++ FS +L+
Sbjct: 368 SLRAL---HLRGYVFQ--ELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFS-NLE 421
Query: 263 YIDISYCNILQPNLKGFPSLRKAILNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRY 321
I +S N + P +K R++ N + R++ +T+ E+ SN +
Sbjct: 422 IIYLSE-NRISPLVK---DTRQSYANSSSFQRHIRKR---RSTDFEFDPHSNFYHFTRPL 474
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMS----VTI 377
+ K LDLS N I I + +P + L LS N ++V S V
Sbjct: 475 IKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKY 534
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNL-------LSYIPDSISSNT-LKYLNLNYN 429
LD+++ L+ +L L + LDLS N +++ + I + T LK LNL++N
Sbjct: 535 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHN 594
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
I ++ + L L GNR ++W D N Y+ N+ R D S
Sbjct: 595 NIYTLTDKYNLESKSLVELVFSGNRLDILWND---DDNRYISIFKGLKNLTRLDLS 647
Score = 63.7 bits (148), Expect = 2e-09
Identities = 100/415 (24%), Positives = 189/415 (45%), Gaps = 36/415 (8%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+ L L L++SS L+ + N+ L+VL+L NY + +LP L
Sbjct: 282 AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP--RL 339
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ILDLSFN + G+ Q + I + L+ + ++H L G + + + +F
Sbjct: 340 EILDLSFNYIK--GSYP-QHINISRNFSKLL----SLRALH----LRGYVFQELREDDFQ 388
Query: 200 PLLRIQNLISSSLRSLFVSNCELT---SLNHNELMFLPSLTHLKMSNNYRLELASSAN-N 255
PL+++ NL + +L F+ + + ++ E+++L + + R A+S++
Sbjct: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 448
Query: 256 LFSQSLKYIDI------SYCNILQPNLKG-FPSLRKAI-LNHNMVRYLESNAFANNTELE 307
+ + D ++ + +P +K + KA+ L+ N + ++ N F N ++
Sbjct: 449 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA 508
Query: 308 YLDLSNNNIASLRYDT-FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN-YLS 365
L+LS N+ A + T F + +K+LDL+ N + +L E+ L L LS N +
Sbjct: 509 CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYF 568
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL- 424
R+ + I + ++ ++ + +++ L L+ S++L+ + S N L L
Sbjct: 569 RIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE-SKSLVELV---FSGNRLDILW 624
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N + NR SI F L LT L + NR I +F + L L ++DNM
Sbjct: 625 NDDDNRYISI----FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM 675
Score = 62.9 bits (146), Expect = 4e-09
Identities = 115/446 (25%), Positives = 184/446 (41%), Gaps = 41/446 (9%)
Query: 63 QVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKG-LPDNA-LYNLTALEVLNLSRN 119
Q+ LN+S+ K + + +L LD+ N L G + A L L LE+L+LS N
Sbjct: 288 QLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN 347
Query: 120 Y----FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
Y + +N++ N L + L+ L L FQ + Q L+ P+L T+ L
Sbjct: 348 YIKGSYPQHINISRNFSKLLS--LRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINF 405
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
I I + N+ ++ L+ N RI L+ + +S S+ +
Sbjct: 406 IKQIDFKL-FQNFSNLEIIYLSEN---RISPLVKDTRQSYANSSSFQRHIRKRRSTDFEF 461
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI--LQPN-LKGFPSLRKAILNHNM- 291
H SN Y + K +D+S +I + PN + P + L+ N
Sbjct: 462 DPH---SNFYHFTRPLIKPQCAAYG-KALDLSLNSIFFIGPNQFENLPDIACLNLSANSN 517
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE----IAVIPE-- 345
+ L F+ ++YLDL+NN + L L+ LDLS+N IA +
Sbjct: 518 AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHL 577
Query: 346 DSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDS-------LEG 395
+ + +L L LS N + + +L S S+ L S L+ + D +G
Sbjct: 578 EFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKG 637
Query: 396 LQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
L+++ LDLS N L +IP+ N +L L++N N + N RL L + G
Sbjct: 638 LKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRG 697
Query: 453 NRFTMIWRRSFFDSNPYLERLDLSDN 478
N+ + S D L L LS N
Sbjct: 698 NKLLFL-TDSLSDFTSSLRTLLLSHN 722
Score = 60.5 bits (140), Expect = 2e-08
Identities = 87/303 (28%), Positives = 124/303 (40%), Gaps = 24/303 (7%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + N NL + LNLS N L+ + H+K LDL+ N+
Sbjct: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAI---PHVKYLDLTNNRL 542
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRIQ-- 205
A EL L+ H I + H + N++VL L+ N + +
Sbjct: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
Query: 206 -NLISSSLRSLFVSNCELTSL-NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
NL S SL L S L L N ++ ++ LK N RL+L S N L K+
Sbjct: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLK--NLTRLDL--SLNRL-----KH 653
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
I N NL SL + +N NM+++ LE LDL N + L
Sbjct: 654 IP----NEAFLNLPA--SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL 707
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSC 383
L+ L LS N I+ +P L E+ SL L LS N L + + T +S
Sbjct: 708 SDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 767
Query: 384 ELN 386
EL+
Sbjct: 768 ELH 770
Score = 55.6 bits (128), Expect = 6e-07
Identities = 74/265 (27%), Positives = 122/265 (46%), Gaps = 21/265 (7%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN--YFDSW 124
L+ ++N S + ++ LD+++N+L +AL L+ LEVL+LS N YF
Sbjct: 512 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA 571
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEI----NSIH 180
+ + + T+LK+L+LS N T+ + N E SL L+ + N
Sbjct: 572 GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE---SKSLVELVFSGNRLDILWNDDD 628
Query: 181 GR--SPLSGLINIRVLKLNFNPLLRIQN----LISSSLRSLFVSNCELTSLNHNELMFLP 234
R S GL N+ L L+ N L I N + +SL L +++ L N L P
Sbjct: 629 NRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFP 688
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PN--LKGFPSLRKAILNHNM 291
L L + N L L S ++ F+ SL+ + +S+ I P+ L SL+ L+ N+
Sbjct: 689 RLELLDLRGNKLLFLTDSLSD-FTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 747
Query: 292 VRYLESNAF--ANNTELEYLDLSNN 314
++ + +A T+L L+L N
Sbjct: 748 LKTINKSALETKTTTKLSMLELHGN 772
Score = 42.3 bits (95), Expect = 0.006
Identities = 74/288 (25%), Positives = 127/288 (44%), Gaps = 21/288 (7%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
A + K LDLS N +G + L P + L L + + S + +++ L
Sbjct: 480 AAYGKALDLSLNSIFFIGPNQFENL---PDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 536
Query: 196 LNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLTH-LKMSNNY-RLELAS- 251
L N L N +S+L L S+ E+ L++N F + +TH L+ N+ L++ +
Sbjct: 537 LT-NNRLDFDN--ASALTEL--SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNL 591
Query: 252 SANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL 311
S NN+++ + KY ++ ++++ G + + N + RY+ + F L LDL
Sbjct: 592 SHNNIYTLTDKY-NLESKSLVELVFSG--NRLDILWNDDDNRYI--SIFKGLKNLTRLDL 646
Query: 312 SNNNIASLRYDTFRGLKM-LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL 370
S N + + + F L L L ++ N + L + P L L L N L +
Sbjct: 647 SLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDS 706
Query: 371 RS---MSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS 415
S S+ L +S ++ + L + S+ LDLS NLL I S
Sbjct: 707 LSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 754
>BC101075-1|AAI01076.1| 1041|Homo sapiens toll-like receptor 8
protein.
Length = 1041
Score = 73.7 bits (173), Expect = 2e-12
Identities = 120/501 (23%), Positives = 215/501 (42%), Gaps = 67/501 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL--- 97
D +CS R L ++P +G VT+L++S+N T ES L NL ++++ N
Sbjct: 43 DSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH 102
Query: 98 ----KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
G+ N L N+T LNL +N + L N + + +LS + +
Sbjct: 103 QNGNPGIQSNGL-NITDGAFLNL-KNLRELLLEDNQLPQIPSGLPESLTELSLIQ-NNIY 159
Query: 154 NLANQELLIRPSLETLILD-HCEINSIHGRSPLSG-----LINIRVLKLNFNPLLRIQNL 207
N+ + + +L+ L L +C N + ++ + L N+ +L L+FN L +
Sbjct: 160 NITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPK 219
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN-----------YRLELASSAN-N 255
+ SSLR LF+SN ++ ++ + L +LT L +S N + +S N +
Sbjct: 220 LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINID 279
Query: 256 LFS----QSLKYIDISYCNILQPN---LKGFPSLRKAILNHN-MVRYLESNAFANN-TEL 306
F+ L+Y+++S ++ + N K P L+ L N +V + S AF L
Sbjct: 280 RFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRL 339
Query: 307 EYLDLSNNNIASLRYD------TFRGLKMLKHLDLSWNEIAVIPEDS---LLEMPSLTQL 357
E LDLS N I F L L+ L L + ED L+++P+L+ +
Sbjct: 340 EILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTI 399
Query: 358 KLSRNYLSRVGH--LRSMS-VTILDMSSCELNTIGKDSLEGL--------------QSIV 400
L N++ ++ ++ S + I+ +S ++ + KD+ + +
Sbjct: 400 NLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF 459
Query: 401 ELDLSQNLLSYIPDSISSNTLKY---LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTM 457
E D N + I Y L+L+ N I I F L + L++ N
Sbjct: 460 EFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 519
Query: 458 IWRRSFFDSNPYLERLDLSDN 478
+ + F + P+++ LDL++N
Sbjct: 520 VLSGTEFSAIPHVKYLDLTNN 540
Score = 64.1 bits (149), Expect = 2e-09
Identities = 131/476 (27%), Positives = 196/476 (41%), Gaps = 70/476 (14%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLK------ 98
+ S L+ +P L + KL +SN + E L NL LD+S N +
Sbjct: 206 LSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPF 265
Query: 99 -------GLPDN----ALYNLTALEVLNLS----RNYFDSWLNLNPNDVLLPATHLKILD 143
G N A NLT L LNLS R +W P HLK+LD
Sbjct: 266 PCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMP--------HLKVLD 317
Query: 144 LSFNKFQTMGNLANQELL-IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
L FN +G +A+ L + P LE L L N I G P INI NF+ LL
Sbjct: 318 LEFNYL--VGEIASGAFLTMLPRLEILDLS---FNYIKGSYPQH--INI---SRNFSKLL 367
Query: 203 RIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLK 262
++ L LR EL + LM LP+L+ + + N+ ++ FS +L+
Sbjct: 368 SLRAL---HLRGYVFQ--ELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFS-NLE 421
Query: 263 YIDISYCNILQPNLKGFPSLRKAILNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRY 321
I +S N + P +K R++ N + R++ +T+ E+ SN +
Sbjct: 422 IIYLSE-NRISPLVK---DTRQSYANSSSFQRHIRKR---RSTDFEFDPHSNFYHFTRPL 474
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMS----VTI 377
+ K LDLS N I I + +P + L LS N ++V S V
Sbjct: 475 IKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKY 534
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNL-------LSYIPDSISSNT-LKYLNLNYN 429
LD+++ L+ +L L + LDLS N +++ + I + T LK LNL++N
Sbjct: 535 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHN 594
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
I ++ + L L GNR ++W D N Y+ N+ R D S
Sbjct: 595 NIYTLTDKYNLESKSLVELVFSGNRLDILWND---DDNRYISIFKGLKNLTRLDLS 647
Score = 63.7 bits (148), Expect = 2e-09
Identities = 100/415 (24%), Positives = 189/415 (45%), Gaps = 36/415 (8%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+ L L L++SS L+ + N+ L+VL+L NY + +LP L
Sbjct: 282 AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP--RL 339
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ILDLSFN + G+ Q + I + L+ + ++H L G + + + +F
Sbjct: 340 EILDLSFNYIK--GSYP-QHINISRNFSKLL----SLRALH----LRGYVFQELREDDFQ 388
Query: 200 PLLRIQNLISSSLRSLFVSNCELT---SLNHNELMFLPSLTHLKMSNNYRLELASSAN-N 255
PL+++ NL + +L F+ + + ++ E+++L + + R A+S++
Sbjct: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 448
Query: 256 LFSQSLKYIDI------SYCNILQPNLKG-FPSLRKAI-LNHNMVRYLESNAFANNTELE 307
+ + D ++ + +P +K + KA+ L+ N + ++ N F N ++
Sbjct: 449 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA 508
Query: 308 YLDLSNNNIASLRYDT-FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN-YLS 365
L+LS N+ A + T F + +K+LDL+ N + +L E+ L L LS N +
Sbjct: 509 CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYF 568
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL- 424
R+ + I + ++ ++ + +++ L L+ S++L+ + S N L L
Sbjct: 569 RIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE-SKSLVELV---FSGNRLDILW 624
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N + NR SI F L LT L + NR I +F + L L ++DNM
Sbjct: 625 NDDDNRYISI----FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM 675
Score = 62.9 bits (146), Expect = 4e-09
Identities = 115/446 (25%), Positives = 184/446 (41%), Gaps = 41/446 (9%)
Query: 63 QVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKG-LPDNA-LYNLTALEVLNLSRN 119
Q+ LN+S+ K + + +L LD+ N L G + A L L LE+L+LS N
Sbjct: 288 QLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN 347
Query: 120 Y----FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
Y + +N++ N L + L+ L L FQ + Q L+ P+L T+ L
Sbjct: 348 YIKGSYPQHINISRNFSKLLS--LRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINF 405
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
I I + N+ ++ L+ N RI L+ + +S S+ +
Sbjct: 406 IKQIDFKL-FQNFSNLEIIYLSEN---RISPLVKDTRQSYANSSSFQRHIRKRRSTDFEF 461
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI--LQPN-LKGFPSLRKAILNHNM- 291
H SN Y + K +D+S +I + PN + P + L+ N
Sbjct: 462 DPH---SNFYHFTRPLIKPQCAAYG-KALDLSLNSIFFIGPNQFENLPDIACLNLSANSN 517
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE----IAVIPE-- 345
+ L F+ ++YLDL+NN + L L+ LDLS+N IA +
Sbjct: 518 AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHL 577
Query: 346 DSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDS-------LEG 395
+ + +L L LS N + + +L S S+ L S L+ + D +G
Sbjct: 578 EFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKG 637
Query: 396 LQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
L+++ LDLS N L +IP+ N +L L++N N + N RL L + G
Sbjct: 638 LKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRG 697
Query: 453 NRFTMIWRRSFFDSNPYLERLDLSDN 478
N+ + S D L L LS N
Sbjct: 698 NKLLFL-TDSLSDFTSSLRTLLLSHN 722
Score = 60.5 bits (140), Expect = 2e-08
Identities = 87/303 (28%), Positives = 124/303 (40%), Gaps = 24/303 (7%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + N NL + LNLS N L+ + H+K LDL+ N+
Sbjct: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAI---PHVKYLDLTNNRL 542
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRIQ-- 205
A EL L+ H I + H + N++VL L+ N + +
Sbjct: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
Query: 206 -NLISSSLRSLFVSNCELTSL-NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
NL S SL L S L L N ++ ++ LK N RL+L S N L K+
Sbjct: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLK--NLTRLDL--SLNRL-----KH 653
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
I N NL SL + +N NM+++ LE LDL N + L
Sbjct: 654 IP----NEAFLNLPA--SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL 707
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSC 383
L+ L LS N I+ +P L E+ SL L LS N L + + T +S
Sbjct: 708 SDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 767
Query: 384 ELN 386
EL+
Sbjct: 768 ELH 770
Score = 55.6 bits (128), Expect = 6e-07
Identities = 74/265 (27%), Positives = 122/265 (46%), Gaps = 21/265 (7%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN--YFDSW 124
L+ ++N S + ++ LD+++N+L +AL L+ LEVL+LS N YF
Sbjct: 512 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA 571
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEI----NSIH 180
+ + + T+LK+L+LS N T+ + N E SL L+ + N
Sbjct: 572 GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE---SKSLVELVFSGNRLDILWNDDD 628
Query: 181 GR--SPLSGLINIRVLKLNFNPLLRIQN----LISSSLRSLFVSNCELTSLNHNELMFLP 234
R S GL N+ L L+ N L I N + +SL L +++ L N L P
Sbjct: 629 NRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFP 688
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PN--LKGFPSLRKAILNHNM 291
L L + N L L S ++ F+ SL+ + +S+ I P+ L SL+ L+ N+
Sbjct: 689 RLELLDLRGNKLLFLTDSLSD-FTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 747
Query: 292 VRYLESNAF--ANNTELEYLDLSNN 314
++ + +A T+L L+L N
Sbjct: 748 LKTINKSALETKTTTKLSMLELHGN 772
Score = 42.3 bits (95), Expect = 0.006
Identities = 74/288 (25%), Positives = 127/288 (44%), Gaps = 21/288 (7%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
A + K LDLS N +G + L P + L L + + S + +++ L
Sbjct: 480 AAYGKALDLSLNSIFFIGPNQFENL---PDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 536
Query: 196 LNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLTH-LKMSNNY-RLELAS- 251
L N L N +S+L L S+ E+ L++N F + +TH L+ N+ L++ +
Sbjct: 537 LT-NNRLDFDN--ASALTEL--SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNL 591
Query: 252 SANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL 311
S NN+++ + KY ++ ++++ G + + N + RY+ + F L LDL
Sbjct: 592 SHNNIYTLTDKY-NLESKSLVELVFSG--NRLDILWNDDDNRYI--SIFKGLKNLTRLDL 646
Query: 312 SNNNIASLRYDTFRGLKM-LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL 370
S N + + + F L L L ++ N + L + P L L L N L +
Sbjct: 647 SLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDS 706
Query: 371 RS---MSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS 415
S S+ L +S ++ + L + S+ LDLS NLL I S
Sbjct: 707 LSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 754
>BC101074-1|AAI01075.1| 1041|Homo sapiens toll-like receptor 8
protein.
Length = 1041
Score = 73.7 bits (173), Expect = 2e-12
Identities = 120/501 (23%), Positives = 215/501 (42%), Gaps = 67/501 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL--- 97
D +CS R L ++P +G VT+L++S+N T ES L NL ++++ N
Sbjct: 43 DSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH 102
Query: 98 ----KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
G+ N L N+T LNL +N + L N + + +LS + +
Sbjct: 103 QNGNPGIQSNGL-NITDGAFLNL-KNLRELLLEDNQLPQIPSGLPESLTELSLIQ-NNIY 159
Query: 154 NLANQELLIRPSLETLILD-HCEINSIHGRSPLSG-----LINIRVLKLNFNPLLRIQNL 207
N+ + + +L+ L L +C N + ++ + L N+ +L L+FN L +
Sbjct: 160 NITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPK 219
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN-----------YRLELASSAN-N 255
+ SSLR LF+SN ++ ++ + L +LT L +S N + +S N +
Sbjct: 220 LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINID 279
Query: 256 LFS----QSLKYIDISYCNILQPN---LKGFPSLRKAILNHN-MVRYLESNAFANN-TEL 306
F+ L+Y+++S ++ + N K P L+ L N +V + S AF L
Sbjct: 280 RFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRL 339
Query: 307 EYLDLSNNNIASLRYD------TFRGLKMLKHLDLSWNEIAVIPEDS---LLEMPSLTQL 357
E LDLS N I F L L+ L L + ED L+++P+L+ +
Sbjct: 340 EILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTI 399
Query: 358 KLSRNYLSRVGH--LRSMS-VTILDMSSCELNTIGKDSLEGL--------------QSIV 400
L N++ ++ ++ S + I+ +S ++ + KD+ + +
Sbjct: 400 NLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF 459
Query: 401 ELDLSQNLLSYIPDSISSNTLKY---LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTM 457
E D N + I Y L+L+ N I I F L + L++ N
Sbjct: 460 EFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 519
Query: 458 IWRRSFFDSNPYLERLDLSDN 478
+ + F + P+++ LDL++N
Sbjct: 520 VLSGTEFSAIPHVKYLDLTNN 540
Score = 64.1 bits (149), Expect = 2e-09
Identities = 131/476 (27%), Positives = 196/476 (41%), Gaps = 70/476 (14%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLK------ 98
+ S L+ +P L + KL +SN + E L NL LD+S N +
Sbjct: 206 LSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPF 265
Query: 99 -------GLPDN----ALYNLTALEVLNLS----RNYFDSWLNLNPNDVLLPATHLKILD 143
G N A NLT L LNLS R +W P HLK+LD
Sbjct: 266 PCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMP--------HLKVLD 317
Query: 144 LSFNKFQTMGNLANQELL-IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
L FN +G +A+ L + P LE L L N I G P INI NF+ LL
Sbjct: 318 LEFNYL--VGEIASGAFLTMLPRLEILDLS---FNYIKGSYPQH--INI---SRNFSKLL 367
Query: 203 RIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLK 262
++ L LR EL + LM LP+L+ + + N+ ++ FS +L+
Sbjct: 368 SLRAL---HLRGYVFQ--ELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFS-NLE 421
Query: 263 YIDISYCNILQPNLKGFPSLRKAILNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRY 321
I +S N + P +K R++ N + R++ +T+ E+ SN +
Sbjct: 422 IIYLSE-NRISPLVK---DTRQSYANSSSFQRHIRKR---RSTDFEFDPHSNFYHFTRPL 474
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMS----VTI 377
+ K LDLS N I I + +P + L LS N ++V S V
Sbjct: 475 IKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKY 534
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNL-------LSYIPDSISSNT-LKYLNLNYN 429
LD+++ L+ +L L + LDLS N +++ + I + T LK LNL++N
Sbjct: 535 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHN 594
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
I ++ + L L GNR ++W D N Y+ N+ R D S
Sbjct: 595 NIYTLTDKYNLESKSLVELVFSGNRLDILWND---DDNRYISIFKGLKNLTRLDLS 647
Score = 63.7 bits (148), Expect = 2e-09
Identities = 100/415 (24%), Positives = 189/415 (45%), Gaps = 36/415 (8%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+ L L L++SS L+ + N+ L+VL+L NY + +LP L
Sbjct: 282 AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP--RL 339
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ILDLSFN + G+ Q + I + L+ + ++H L G + + + +F
Sbjct: 340 EILDLSFNYIK--GSYP-QHINISRNFSKLL----SLRALH----LRGYVFQELREDDFQ 388
Query: 200 PLLRIQNLISSSLRSLFVSNCELT---SLNHNELMFLPSLTHLKMSNNYRLELASSAN-N 255
PL+++ NL + +L F+ + + ++ E+++L + + R A+S++
Sbjct: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 448
Query: 256 LFSQSLKYIDI------SYCNILQPNLKG-FPSLRKAI-LNHNMVRYLESNAFANNTELE 307
+ + D ++ + +P +K + KA+ L+ N + ++ N F N ++
Sbjct: 449 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA 508
Query: 308 YLDLSNNNIASLRYDT-FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN-YLS 365
L+LS N+ A + T F + +K+LDL+ N + +L E+ L L LS N +
Sbjct: 509 CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYF 568
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL- 424
R+ + I + ++ ++ + +++ L L+ S++L+ + S N L L
Sbjct: 569 RIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE-SKSLVELV---FSGNRLDILW 624
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N + NR SI F L LT L + NR I +F + L L ++DNM
Sbjct: 625 NDDDNRYISI----FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM 675
Score = 62.9 bits (146), Expect = 4e-09
Identities = 115/446 (25%), Positives = 184/446 (41%), Gaps = 41/446 (9%)
Query: 63 QVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKG-LPDNA-LYNLTALEVLNLSRN 119
Q+ LN+S+ K + + +L LD+ N L G + A L L LE+L+LS N
Sbjct: 288 QLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN 347
Query: 120 Y----FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
Y + +N++ N L + L+ L L FQ + Q L+ P+L T+ L
Sbjct: 348 YIKGSYPQHINISRNFSKLLS--LRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINF 405
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
I I + N+ ++ L+ N RI L+ + +S S+ +
Sbjct: 406 IKQIDFKL-FQNFSNLEIIYLSEN---RISPLVKDTRQSYANSSSFQRHIRKRRSTDFEF 461
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI--LQPN-LKGFPSLRKAILNHNM- 291
H SN Y + K +D+S +I + PN + P + L+ N
Sbjct: 462 DPH---SNFYHFTRPLIKPQCAAYG-KALDLSLNSIFFIGPNQFENLPDIACLNLSANSN 517
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE----IAVIPE-- 345
+ L F+ ++YLDL+NN + L L+ LDLS+N IA +
Sbjct: 518 AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHL 577
Query: 346 DSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDS-------LEG 395
+ + +L L LS N + + +L S S+ L S L+ + D +G
Sbjct: 578 EFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKG 637
Query: 396 LQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
L+++ LDLS N L +IP+ N +L L++N N + N RL L + G
Sbjct: 638 LKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRG 697
Query: 453 NRFTMIWRRSFFDSNPYLERLDLSDN 478
N+ + S D L L LS N
Sbjct: 698 NKLLFL-TDSLSDFTSSLRTLLLSHN 722
Score = 60.5 bits (140), Expect = 2e-08
Identities = 87/303 (28%), Positives = 124/303 (40%), Gaps = 24/303 (7%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + N NL + LNLS N L+ + H+K LDL+ N+
Sbjct: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAI---PHVKYLDLTNNRL 542
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRIQ-- 205
A EL L+ H I + H + N++VL L+ N + +
Sbjct: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
Query: 206 -NLISSSLRSLFVSNCELTSL-NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
NL S SL L S L L N ++ ++ LK N RL+L S N L K+
Sbjct: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLK--NLTRLDL--SLNRL-----KH 653
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
I N NL SL + +N NM+++ LE LDL N + L
Sbjct: 654 IP----NEAFLNLPA--SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL 707
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSC 383
L+ L LS N I+ +P L E+ SL L LS N L + + T +S
Sbjct: 708 SDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 767
Query: 384 ELN 386
EL+
Sbjct: 768 ELH 770
Score = 55.6 bits (128), Expect = 6e-07
Identities = 74/265 (27%), Positives = 122/265 (46%), Gaps = 21/265 (7%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN--YFDSW 124
L+ ++N S + ++ LD+++N+L +AL L+ LEVL+LS N YF
Sbjct: 512 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA 571
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEI----NSIH 180
+ + + T+LK+L+LS N T+ + N E SL L+ + N
Sbjct: 572 GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE---SKSLVELVFSGNRLDILWNDDD 628
Query: 181 GR--SPLSGLINIRVLKLNFNPLLRIQN----LISSSLRSLFVSNCELTSLNHNELMFLP 234
R S GL N+ L L+ N L I N + +SL L +++ L N L P
Sbjct: 629 NRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFP 688
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PN--LKGFPSLRKAILNHNM 291
L L + N L L S ++ F+ SL+ + +S+ I P+ L SL+ L+ N+
Sbjct: 689 RLELLDLRGNKLLFLTDSLSD-FTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 747
Query: 292 VRYLESNAF--ANNTELEYLDLSNN 314
++ + +A T+L L+L N
Sbjct: 748 LKTINKSALETKTTTKLSMLELHGN 772
Score = 42.3 bits (95), Expect = 0.006
Identities = 74/288 (25%), Positives = 127/288 (44%), Gaps = 21/288 (7%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
A + K LDLS N +G + L P + L L + + S + +++ L
Sbjct: 480 AAYGKALDLSLNSIFFIGPNQFENL---PDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 536
Query: 196 LNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLTH-LKMSNNY-RLELAS- 251
L N L N +S+L L S+ E+ L++N F + +TH L+ N+ L++ +
Sbjct: 537 LT-NNRLDFDN--ASALTEL--SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNL 591
Query: 252 SANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL 311
S NN+++ + KY ++ ++++ G + + N + RY+ + F L LDL
Sbjct: 592 SHNNIYTLTDKY-NLESKSLVELVFSG--NRLDILWNDDDNRYI--SIFKGLKNLTRLDL 646
Query: 312 SNNNIASLRYDTFRGLKM-LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL 370
S N + + + F L L L ++ N + L + P L L L N L +
Sbjct: 647 SLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDS 706
Query: 371 RS---MSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS 415
S S+ L +S ++ + L + S+ LDLS NLL I S
Sbjct: 707 LSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 754
>AF245703-1|AAF78036.1| 1041|Homo sapiens toll-like receptor 8
protein.
Length = 1041
Score = 73.7 bits (173), Expect = 2e-12
Identities = 120/501 (23%), Positives = 215/501 (42%), Gaps = 67/501 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL--- 97
D +CS R L ++P +G VT+L++S+N T ES L NL ++++ N
Sbjct: 43 DSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH 102
Query: 98 ----KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
G+ N L N+T LNL +N + L N + + +LS + +
Sbjct: 103 QNGNPGIQSNGL-NITDGAFLNL-KNLRELLLEDNQLPQIPSGLPESLTELSLIQ-NNIY 159
Query: 154 NLANQELLIRPSLETLILD-HCEINSIHGRSPLSG-----LINIRVLKLNFNPLLRIQNL 207
N+ + + +L+ L L +C N + ++ + L N+ +L L+FN L +
Sbjct: 160 NITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPK 219
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN-----------YRLELASSAN-N 255
+ SSLR LF+SN ++ ++ + L +LT L +S N + +S N +
Sbjct: 220 LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINID 279
Query: 256 LFS----QSLKYIDISYCNILQPN---LKGFPSLRKAILNHN-MVRYLESNAFANN-TEL 306
F+ L+Y+++S ++ + N K P L+ L N +V + S AF L
Sbjct: 280 RFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRL 339
Query: 307 EYLDLSNNNIASLRYD------TFRGLKMLKHLDLSWNEIAVIPEDS---LLEMPSLTQL 357
E LDLS N I F L L+ L L + ED L+++P+L+ +
Sbjct: 340 EILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTI 399
Query: 358 KLSRNYLSRVGH--LRSMS-VTILDMSSCELNTIGKDSLEGL--------------QSIV 400
L N++ ++ ++ S + I+ +S ++ + KD+ + +
Sbjct: 400 NLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF 459
Query: 401 ELDLSQNLLSYIPDSISSNTLKY---LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTM 457
E D N + I Y L+L+ N I I F L + L++ N
Sbjct: 460 EFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 519
Query: 458 IWRRSFFDSNPYLERLDLSDN 478
+ + F + P+++ LDL++N
Sbjct: 520 VLSGTEFSAIPHVKYLDLTNN 540
Score = 64.1 bits (149), Expect = 2e-09
Identities = 131/476 (27%), Positives = 196/476 (41%), Gaps = 70/476 (14%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLK------ 98
+ S L+ +P L + KL +SN + E L NL LD+S N +
Sbjct: 206 LSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPF 265
Query: 99 -------GLPDN----ALYNLTALEVLNLS----RNYFDSWLNLNPNDVLLPATHLKILD 143
G N A NLT L LNLS R +W P HLK+LD
Sbjct: 266 PCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMP--------HLKVLD 317
Query: 144 LSFNKFQTMGNLANQELL-IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
L FN +G +A+ L + P LE L L N I G P INI NF+ LL
Sbjct: 318 LEFNYL--VGEIASGAFLTMLPRLEILDLS---FNYIKGSYPQH--INI---SRNFSKLL 367
Query: 203 RIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLK 262
++ L LR EL + LM LP+L+ + + N+ ++ FS +L+
Sbjct: 368 SLRAL---HLRGYVFQ--ELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFS-NLE 421
Query: 263 YIDISYCNILQPNLKGFPSLRKAILNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRY 321
I +S N + P +K R++ N + R++ +T+ E+ SN +
Sbjct: 422 IIYLSE-NRISPLVK---DTRQSYANSSSFQRHIRKR---RSTDFEFDPHSNFYHFTRPL 474
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMS----VTI 377
+ K LDLS N I I + +P + L LS N ++V S V
Sbjct: 475 IKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKY 534
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNL-------LSYIPDSISSNT-LKYLNLNYN 429
LD+++ L+ +L L + LDLS N +++ + I + T LK LNL++N
Sbjct: 535 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHN 594
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
I ++ + L L GNR ++W D N Y+ N+ R D S
Sbjct: 595 NIYTLTDKYNLESKSLVELVFSGNRLDILWND---DDNRYISIFKGLKNLTRLDLS 647
Score = 63.7 bits (148), Expect = 2e-09
Identities = 100/415 (24%), Positives = 189/415 (45%), Gaps = 36/415 (8%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+ L L L++SS L+ + N+ L+VL+L NY + +LP L
Sbjct: 282 AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP--RL 339
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ILDLSFN + G+ Q + I + L+ + ++H L G + + + +F
Sbjct: 340 EILDLSFNYIK--GSYP-QHINISRNFSKLL----SLRALH----LRGYVFQELREDDFQ 388
Query: 200 PLLRIQNLISSSLRSLFVSNCELT---SLNHNELMFLPSLTHLKMSNNYRLELASSAN-N 255
PL+++ NL + +L F+ + + ++ E+++L + + R A+S++
Sbjct: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 448
Query: 256 LFSQSLKYIDI------SYCNILQPNLKG-FPSLRKAI-LNHNMVRYLESNAFANNTELE 307
+ + D ++ + +P +K + KA+ L+ N + ++ N F N ++
Sbjct: 449 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA 508
Query: 308 YLDLSNNNIASLRYDT-FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN-YLS 365
L+LS N+ A + T F + +K+LDL+ N + +L E+ L L LS N +
Sbjct: 509 CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYF 568
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL- 424
R+ + I + ++ ++ + +++ L L+ S++L+ + S N L L
Sbjct: 569 RIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE-SKSLVELV---FSGNRLDILW 624
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N + NR SI F L LT L + NR I +F + L L ++DNM
Sbjct: 625 NDDDNRYISI----FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM 675
Score = 62.9 bits (146), Expect = 4e-09
Identities = 115/446 (25%), Positives = 184/446 (41%), Gaps = 41/446 (9%)
Query: 63 QVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKG-LPDNA-LYNLTALEVLNLSRN 119
Q+ LN+S+ K + + +L LD+ N L G + A L L LE+L+LS N
Sbjct: 288 QLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN 347
Query: 120 Y----FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
Y + +N++ N L + L+ L L FQ + Q L+ P+L T+ L
Sbjct: 348 YIKGSYPQHINISRNFSKLLS--LRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINF 405
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
I I + N+ ++ L+ N RI L+ + +S S+ +
Sbjct: 406 IKQIDFKL-FQNFSNLEIIYLSEN---RISPLVKDTRQSYANSSSFQRHIRKRRSTDFEF 461
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI--LQPN-LKGFPSLRKAILNHNM- 291
H SN Y + K +D+S +I + PN + P + L+ N
Sbjct: 462 DPH---SNFYHFTRPLIKPQCAAYG-KALDLSLNSIFFIGPNQFENLPDIACLNLSANSN 517
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE----IAVIPE-- 345
+ L F+ ++YLDL+NN + L L+ LDLS+N IA +
Sbjct: 518 AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHL 577
Query: 346 DSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDS-------LEG 395
+ + +L L LS N + + +L S S+ L S L+ + D +G
Sbjct: 578 EFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKG 637
Query: 396 LQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
L+++ LDLS N L +IP+ N +L L++N N + N RL L + G
Sbjct: 638 LKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRG 697
Query: 453 NRFTMIWRRSFFDSNPYLERLDLSDN 478
N+ + S D L L LS N
Sbjct: 698 NKLLFL-TDSLSDFTSSLRTLLLSHN 722
Score = 60.5 bits (140), Expect = 2e-08
Identities = 87/303 (28%), Positives = 124/303 (40%), Gaps = 24/303 (7%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + N NL + LNLS N L+ + H+K LDL+ N+
Sbjct: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAI---PHVKYLDLTNNRL 542
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRIQ-- 205
A EL L+ H I + H + N++VL L+ N + +
Sbjct: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
Query: 206 -NLISSSLRSLFVSNCELTSL-NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
NL S SL L S L L N ++ ++ LK N RL+L S N L K+
Sbjct: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLK--NLTRLDL--SLNRL-----KH 653
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
I N NL SL + +N NM+++ LE LDL N + L
Sbjct: 654 IP----NEAFLNLPA--SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL 707
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSC 383
L+ L LS N I+ +P L E+ SL L LS N L + + T +S
Sbjct: 708 SDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 767
Query: 384 ELN 386
EL+
Sbjct: 768 ELH 770
Score = 55.6 bits (128), Expect = 6e-07
Identities = 74/265 (27%), Positives = 122/265 (46%), Gaps = 21/265 (7%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN--YFDSW 124
L+ ++N S + ++ LD+++N+L +AL L+ LEVL+LS N YF
Sbjct: 512 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA 571
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEI----NSIH 180
+ + + T+LK+L+LS N T+ + N E SL L+ + N
Sbjct: 572 GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE---SKSLVELVFSGNRLDILWNDDD 628
Query: 181 GR--SPLSGLINIRVLKLNFNPLLRIQN----LISSSLRSLFVSNCELTSLNHNELMFLP 234
R S GL N+ L L+ N L I N + +SL L +++ L N L P
Sbjct: 629 NRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFP 688
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PN--LKGFPSLRKAILNHNM 291
L L + N L L S ++ F+ SL+ + +S+ I P+ L SL+ L+ N+
Sbjct: 689 RLELLDLRGNKLLFLTDSLSD-FTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 747
Query: 292 VRYLESNAF--ANNTELEYLDLSNN 314
++ + +A T+L L+L N
Sbjct: 748 LKTINKSALETKTTTKLSMLELHGN 772
Score = 42.3 bits (95), Expect = 0.006
Identities = 74/288 (25%), Positives = 127/288 (44%), Gaps = 21/288 (7%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
A + K LDLS N +G + L P + L L + + S + +++ L
Sbjct: 480 AAYGKALDLSLNSIFFIGPNQFENL---PDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 536
Query: 196 LNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLTH-LKMSNNY-RLELAS- 251
L N L N +S+L L S+ E+ L++N F + +TH L+ N+ L++ +
Sbjct: 537 LT-NNRLDFDN--ASALTEL--SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNL 591
Query: 252 SANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL 311
S NN+++ + KY ++ ++++ G + + N + RY+ + F L LDL
Sbjct: 592 SHNNIYTLTDKY-NLESKSLVELVFSG--NRLDILWNDDDNRYI--SIFKGLKNLTRLDL 646
Query: 312 SNNNIASLRYDTFRGLKM-LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL 370
S N + + + F L L L ++ N + L + P L L L N L +
Sbjct: 647 SLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDS 706
Query: 371 RS---MSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS 415
S S+ L +S ++ + L + S+ LDLS NLL I S
Sbjct: 707 LSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 754
>DQ084201-1|AAY86708.1| 640|Homo sapiens netrin-G1 ligand splice
variant 3 protein.
Length = 640
Score = 73.3 bits (172), Expect = 3e-12
Identities = 62/204 (30%), Positives = 94/204 (46%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N +R +E AF L L+L +N + ++ F L LK L L N I IP
Sbjct: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTISNGAFVYLSKLKELWLRNNPIESIPSY 166
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L +Y+S ++ L+++ C L I +L L + EL
Sbjct: 167 AFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREI--PNLTPLIKLDEL 224
Query: 403 DLSQNLLSYI-PDSISSNT-LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
DLS N LS I P S L+ L + ++I I F L L +++ N T++
Sbjct: 225 DLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLL-P 283
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F +LER+ L N W C+C
Sbjct: 284 HDLFTPLHHLERIHLHHNPWSCNC 307
Score = 69.3 bits (162), Expect = 5e-11
Identities = 54/196 (27%), Positives = 98/196 (50%), Gaps = 5/196 (2%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N ++ ++ N+F + LE L LS N+I ++ F GL L L+L N + I
Sbjct: 83 LHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTISNG 142
Query: 347 SLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSCE-LNTIGKDSLEGLQSIVEL 402
+ + + L +L L N + + R S+ LD+ + L+ I + + EGL ++ L
Sbjct: 143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYL 202
Query: 403 DLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRS 462
+L+ L IP+ L L+L+ N +S+I +F L L L ++ ++ +I R+
Sbjct: 203 NLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVI-ERN 261
Query: 463 FFDSNPYLERLDLSDN 478
FD+ L ++L+ N
Sbjct: 262 AFDNLQSLVEINLAHN 277
Score = 66.9 bits (156), Expect = 2e-10
Identities = 63/250 (25%), Positives = 114/250 (45%), Gaps = 8/250 (3%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
+T+ ++L+L N+ Q + N +R LE L L I +I +GL N+ L+
Sbjct: 75 STNTRLLNLHENQIQIIK--VNSFKHLR-HLEILQLSRNHIRTIE-IGAFNGLANLNTLE 130
Query: 196 LNFNPLLRIQN---LISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASS 252
L N L I N + S L+ L++ N + S+ +PSL L + RL S
Sbjct: 131 LFDNRLTTISNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISE 190
Query: 253 ANNLFSQSLKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL 311
+L+Y++++ CN+ + PNL L + L+ N + + +F L+ L +
Sbjct: 191 GAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWM 250
Query: 312 SNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLR 371
+ I + + F L+ L ++L+ N + ++P D + L ++ L N S +
Sbjct: 251 IQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWSCNCDIL 310
Query: 372 SMSVTILDMS 381
+S I DM+
Sbjct: 311 WLSWWIKDMA 320
Score = 64.5 bits (150), Expect = 1e-09
Identities = 60/237 (25%), Positives = 114/237 (48%), Gaps = 10/237 (4%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ- 259
L + + IS++ R L + ++ + N L L L++S N+ + A N +
Sbjct: 67 LREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANL 126
Query: 260 -SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIA 317
+L+ D I L++ L +N + + S AF L LDL ++
Sbjct: 127 NTLELFDNRLTTISNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLS 186
Query: 318 SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS--RVGHLRS-MS 374
+ F GL L++L+L+ + IP +L + L +L LS N+LS R G + M
Sbjct: 187 YISEGAFEGLSNLRYLNLAMCNLREIP--NLTPLIKLDELDLSGNHLSAIRPGSFQGLMH 244
Query: 375 VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYN 429
+ L M ++ I +++ + LQS+VE++L+ N L+ +P + + + L+ ++L++N
Sbjct: 245 LQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
Score = 61.3 bits (142), Expect = 1e-08
Identities = 70/261 (26%), Positives = 112/261 (42%), Gaps = 15/261 (5%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISS 94
+C C+ + + C R+ L ++P+G+ LN+ N+ S L +L L +S
Sbjct: 50 VCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSR 109
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N ++ + A L L L L FD+ L N + + LK L L N +++ +
Sbjct: 110 NHIRTIEIGAFNGLANLNTLEL----FDNRLTTISNGAFVYLSKLKELWLRNNPIESIPS 165
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS-SSLR 213
A + PSL L L + S GL N+R L L L I NL L
Sbjct: 166 YAFNRI---PSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLD 222
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCNI- 271
L +S L+++ L L L M + + +A +NL QSL I++++ N+
Sbjct: 223 ELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNL--QSLVEINLAHNNLT 280
Query: 272 LQPNLKGFP--SLRKAILNHN 290
L P+ P L + L+HN
Sbjct: 281 LLPHDLFTPLHHLERIHLHHN 301
>BC110058-1|AAI10059.1| 518|Homo sapiens leucine rich repeat
transmembrane neuronal 4 protein.
Length = 518
Score = 73.3 bits (172), Expect = 3e-12
Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N ++ L+SN FA +L +L L +N I+S+ D F+G++ LK L LS N+I +
Sbjct: 68 LRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNK 127
Query: 347 SLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ +P+L L LS N L + + + + IL + S L T+ + +++ LD
Sbjct: 128 TFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLD 187
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L N L + + + LK L+L +N+ S IN F L L S+ + NR I +
Sbjct: 188 LGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG 247
Query: 462 SFFDSNPYLERLDLSDN 478
+ + L LDLS N
Sbjct: 248 LTWTWSS-LHNLDLSGN 263
Score = 70.1 bits (164), Expect = 3e-11
Identities = 55/175 (31%), Positives = 87/175 (49%), Gaps = 10/175 (5%)
Query: 294 YLESNAFANNTE-----LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
Y ES+AFA+ E + L L N+I L+ + F GL L L L N I+ + ED+
Sbjct: 46 YCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAF 105
Query: 349 LEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+ L +L LS N YL ++ LD+S +L T+ + +GL+ ++ L L
Sbjct: 106 QGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLR 165
Query: 406 QNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
N L +P + L +L+L YNR+ S++ F L +L L + N+F+ I
Sbjct: 166 SNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKI 220
Score = 69.7 bits (163), Expect = 3e-11
Identities = 68/261 (26%), Positives = 118/261 (45%), Gaps = 12/261 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D +Y + + + +G L++ IL+ N + YL + F L LDLS N + +L+
Sbjct: 91 YLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTIL 378
+ F+GL+ L L L N + +P + +L L L N LSR + + L
Sbjct: 151 EQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKEL 210
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINN 436
+ + + I L ++ + L N + I + + ++L L+L+ N I I
Sbjct: 211 HLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEP 270
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFV 496
TF L L L++ N+ T I + + ++ L + LS NMW +CS FY
Sbjct: 271 GTFKCLPNLQKLNLDSNKLTNISQET-VNAWISLISITLSGNMW--ECSRSICPLFYWLK 327
Query: 497 TLEPNKKEESFNLICNSPANV 517
+ NK+ +IC P ++
Sbjct: 328 NFKGNKES---TMICAGPKHI 345
Score = 53.2 bits (122), Expect = 3e-06
Identities = 71/288 (24%), Positives = 124/288 (43%), Gaps = 24/288 (8%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSN 95
CRC D + C DIP + L++ N K + + L+ L+ L + N
Sbjct: 38 CRC--DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + ++A + L+ L LS N ++L+ N P +L+ LDLS+NK QT L
Sbjct: 96 YISSVDEDAFQGIRRLKELILSSNKI-TYLH---NKTFHPVPNLRNLDLSYNKLQT---L 148
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPL---SGLINIRVLKLNFNPLLRI-QNLISS- 210
+++ L LI+ H NS+ P+ N+ L L +N L + +N +
Sbjct: 149 QSEQF---KGLRKLIILHLRSNSLK-TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGL 204
Query: 211 -SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + + + +N L +L + + N R+ S SL +D+S
Sbjct: 205 LKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWN-RIRSISQGLTWTWSSLHNLDLSGN 263
Query: 270 NI--LQP-NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+I ++P K P+L+K L+ N + + L + LS N
Sbjct: 264 DIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
>BC107493-1|AAI07494.1| 699|Homo sapiens extracellular matrix
protein 2, female organ and adipocyte specific protein.
Length = 699
Score = 73.3 bits (172), Expect = 3e-12
Identities = 93/343 (27%), Positives = 148/343 (43%), Gaps = 30/343 (8%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL 97
C+L I C LT IP Q+T L ++ N P E+ + L NL LD+S N +
Sbjct: 320 CSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNI 379
Query: 98 --KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG-- 153
G+ A L L LN+ N NL LP+T L+ L ++ N Q +
Sbjct: 380 TSSGIGPKAFKLLKKLMRLNMDGN------NLIQIPSQLPST-LEELKVNENNLQAIDEE 432
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+L++ L+ LE L +N + PL L +R+ K N I + S+
Sbjct: 433 SLSDLNQLVTLELEGNNLSEANVNPL-AFKPLKSLAYLRLGK---NKFRIIPQGLPGSIE 488
Query: 214 SLFVSNCELTSL-----NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
L++ N ++ + NH + + L + K+ N LA + ++L+ ID+SY
Sbjct: 489 ELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAW----INQENLESIDLSY 544
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFAN-NTELEYLDLSNNNIASLRYD--TFR 325
+ SL +L N + + F + LEYL LS N +A D +F
Sbjct: 545 NKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFY 604
Query: 326 G-LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
G L+ L L N++ IP + EM +L L+L+ N + +
Sbjct: 605 GAYHSLRELFLDHNDLKSIP-PGIQEMKALHFLRLNNNKIRNI 646
Score = 48.0 bits (109), Expect = 1e-04
Identities = 33/108 (30%), Positives = 56/108 (51%), Gaps = 2/108 (1%)
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI--AVIPEDSLLEMPSLTQLKLSRN 362
++ L+L+ N+IAS+ + F GL L+ LDLS N I + I + + L +L + N
Sbjct: 344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGN 403
Query: 363 YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLS 410
L ++ ++ L ++ L I ++SL L +V L+L N LS
Sbjct: 404 NLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 451
Score = 46.8 bits (106), Expect = 3e-04
Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 20/124 (16%)
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDS 392
L+L+ N IA IP+++ +P+L +L LS+N ++ G IG +
Sbjct: 348 LELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSG-------------------IGPKA 388
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
+ L+ ++ L++ N L IP + S TL+ L +N N + +I+ + LN+L +L + G
Sbjct: 389 FKLLKKLMRLNMDGNNLIQIPSQLPS-TLEELKVNENNLQAIDEESLSDLNQLVTLELEG 447
Query: 453 NRFT 456
N +
Sbjct: 448 NNLS 451
>BC099738-1|AAH99738.1| 518|Homo sapiens leucine rich repeat
transmembrane neuronal 4 protein.
Length = 518
Score = 73.3 bits (172), Expect = 3e-12
Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N ++ L+SN FA +L +L L +N I+S+ D F+G++ LK L LS N+I +
Sbjct: 68 LRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNK 127
Query: 347 SLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ +P+L L LS N L + + + + IL + S L T+ + +++ LD
Sbjct: 128 TFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLD 187
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L N L + + + LK L+L +N+ S IN F L L S+ + NR I +
Sbjct: 188 LGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG 247
Query: 462 SFFDSNPYLERLDLSDN 478
+ + L LDLS N
Sbjct: 248 LTWTWSS-LHNLDLSGN 263
Score = 70.1 bits (164), Expect = 3e-11
Identities = 55/175 (31%), Positives = 87/175 (49%), Gaps = 10/175 (5%)
Query: 294 YLESNAFANNTE-----LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
Y ES+AFA+ E + L L N+I L+ + F GL L L L N I+ + ED+
Sbjct: 46 YCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAF 105
Query: 349 LEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+ L +L LS N YL ++ LD+S +L T+ + +GL+ ++ L L
Sbjct: 106 QGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLR 165
Query: 406 QNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
N L +P + L +L+L YNR+ S++ F L +L L + N+F+ I
Sbjct: 166 SNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKI 220
Score = 69.7 bits (163), Expect = 3e-11
Identities = 68/261 (26%), Positives = 118/261 (45%), Gaps = 12/261 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D +Y + + + +G L++ IL+ N + YL + F L LDLS N + +L+
Sbjct: 91 YLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTIL 378
+ F+GL+ L L L N + +P + +L L L N LSR + + L
Sbjct: 151 EQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKEL 210
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINN 436
+ + + I L ++ + L N + I + + ++L L+L+ N I I
Sbjct: 211 HLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEP 270
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFV 496
TF L L L++ N+ T I + + ++ L + LS NMW +CS FY
Sbjct: 271 GTFKCLPNLQKLNLDSNKLTNISQET-VNAWISLISITLSGNMW--ECSRSICPLFYWLK 327
Query: 497 TLEPNKKEESFNLICNSPANV 517
+ NK+ +IC P ++
Sbjct: 328 NFKGNKES---TMICAGPKHI 345
Score = 53.2 bits (122), Expect = 3e-06
Identities = 71/288 (24%), Positives = 124/288 (43%), Gaps = 24/288 (8%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSN 95
CRC D + C DIP + L++ N K + + L+ L+ L + N
Sbjct: 38 CRC--DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + ++A + L+ L LS N ++L+ N P +L+ LDLS+NK QT L
Sbjct: 96 YISSVDEDAFQGIRRLKELILSSNKI-TYLH---NKTFHPVPNLRNLDLSYNKLQT---L 148
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPL---SGLINIRVLKLNFNPLLRI-QNLISS- 210
+++ L LI+ H NS+ P+ N+ L L +N L + +N +
Sbjct: 149 QSEQF---KGLRKLIILHLRSNSLK-TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGL 204
Query: 211 -SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + + + +N L +L + + N R+ S SL +D+S
Sbjct: 205 LKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWN-RIRSISQGLTWTWSSLHNLDLSGN 263
Query: 270 NI--LQP-NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+I ++P K P+L+K L+ N + + L + LS N
Sbjct: 264 DIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
>BC098301-1|AAH98301.1| 519|Homo sapiens LRRTM4 protein protein.
Length = 519
Score = 73.3 bits (172), Expect = 3e-12
Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N ++ L+SN FA +L +L L +N I+S+ D F+G++ LK L LS N+I +
Sbjct: 69 LRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNK 128
Query: 347 SLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ +P+L L LS N L + + + + IL + S L T+ + +++ LD
Sbjct: 129 TFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLD 188
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L N L + + + LK L+L +N+ S IN F L L S+ + NR I +
Sbjct: 189 LGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG 248
Query: 462 SFFDSNPYLERLDLSDN 478
+ + L LDLS N
Sbjct: 249 LTWTWSS-LHNLDLSGN 264
Score = 70.1 bits (164), Expect = 3e-11
Identities = 55/175 (31%), Positives = 87/175 (49%), Gaps = 10/175 (5%)
Query: 294 YLESNAFANNTE-----LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
Y ES+AFA+ E + L L N+I L+ + F GL L L L N I+ + ED+
Sbjct: 47 YCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAF 106
Query: 349 LEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+ L +L LS N YL ++ LD+S +L T+ + +GL+ ++ L L
Sbjct: 107 QGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLR 166
Query: 406 QNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
N L +P + L +L+L YNR+ S++ F L +L L + N+F+ I
Sbjct: 167 SNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKI 221
Score = 69.7 bits (163), Expect = 3e-11
Identities = 68/261 (26%), Positives = 118/261 (45%), Gaps = 12/261 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D +Y + + + +G L++ IL+ N + YL + F L LDLS N + +L+
Sbjct: 92 YLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQS 151
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTIL 378
+ F+GL+ L L L N + +P + +L L L N LSR + + L
Sbjct: 152 EQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKEL 211
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINN 436
+ + + I L ++ + L N + I + + ++L L+L+ N I I
Sbjct: 212 HLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEP 271
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFV 496
TF L L L++ N+ T I + + ++ L + LS NMW +CS FY
Sbjct: 272 GTFKCLPNLQKLNLDSNKLTNISQET-VNAWISLISITLSGNMW--ECSRSICPLFYWLK 328
Query: 497 TLEPNKKEESFNLICNSPANV 517
+ NK+ +IC P ++
Sbjct: 329 NFKGNKES---TMICAGPKHI 346
Score = 53.2 bits (122), Expect = 3e-06
Identities = 71/288 (24%), Positives = 124/288 (43%), Gaps = 24/288 (8%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSN 95
CRC D + C DIP + L++ N K + + L+ L+ L + N
Sbjct: 39 CRC--DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN 96
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + ++A + L+ L LS N ++L+ N P +L+ LDLS+NK QT L
Sbjct: 97 YISSVDEDAFQGIRRLKELILSSNKI-TYLH---NKTFHPVPNLRNLDLSYNKLQT---L 149
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPL---SGLINIRVLKLNFNPLLRI-QNLISS- 210
+++ L LI+ H NS+ P+ N+ L L +N L + +N +
Sbjct: 150 QSEQF---KGLRKLIILHLRSNSLK-TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGL 205
Query: 211 -SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + + + +N L +L + + N R+ S SL +D+S
Sbjct: 206 LKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWN-RIRSISQGLTWTWSSLHNLDLSGN 264
Query: 270 NI--LQP-NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+I ++P K P+L+K L+ N + + L + LS N
Sbjct: 265 DIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 312
>BC098267-1|AAH98267.1| 519|Homo sapiens LRRTM4 protein protein.
Length = 519
Score = 73.3 bits (172), Expect = 3e-12
Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N ++ L+SN FA +L +L L +N I+S+ D F+G++ LK L LS N+I +
Sbjct: 69 LRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNK 128
Query: 347 SLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ +P+L L LS N L + + + + IL + S L T+ + +++ LD
Sbjct: 129 TFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLD 188
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L N L + + + LK L+L +N+ S IN F L L S+ + NR I +
Sbjct: 189 LGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG 248
Query: 462 SFFDSNPYLERLDLSDN 478
+ + L LDLS N
Sbjct: 249 LTWTWSS-LHNLDLSGN 264
Score = 70.1 bits (164), Expect = 3e-11
Identities = 55/175 (31%), Positives = 87/175 (49%), Gaps = 10/175 (5%)
Query: 294 YLESNAFANNTE-----LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
Y ES+AFA+ E + L L N+I L+ + F GL L L L N I+ + ED+
Sbjct: 47 YCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAF 106
Query: 349 LEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+ L +L LS N YL ++ LD+S +L T+ + +GL+ ++ L L
Sbjct: 107 QGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLR 166
Query: 406 QNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
N L +P + L +L+L YNR+ S++ F L +L L + N+F+ I
Sbjct: 167 SNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKI 221
Score = 69.7 bits (163), Expect = 3e-11
Identities = 68/261 (26%), Positives = 118/261 (45%), Gaps = 12/261 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D +Y + + + +G L++ IL+ N + YL + F L LDLS N + +L+
Sbjct: 92 YLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQS 151
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTIL 378
+ F+GL+ L L L N + +P + +L L L N LSR + + L
Sbjct: 152 EQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKEL 211
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINN 436
+ + + I L ++ + L N + I + + ++L L+L+ N I I
Sbjct: 212 HLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEP 271
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFV 496
TF L L L++ N+ T I + + ++ L + LS NMW +CS FY
Sbjct: 272 GTFKCLPNLQKLNLDSNKLTNISQET-VNAWISLISITLSGNMW--ECSRSICPLFYWLK 328
Query: 497 TLEPNKKEESFNLICNSPANV 517
+ NK+ +IC P ++
Sbjct: 329 NFKGNKES---TMICAGPKHI 346
Score = 53.2 bits (122), Expect = 3e-06
Identities = 71/288 (24%), Positives = 124/288 (43%), Gaps = 24/288 (8%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSN 95
CRC D + C DIP + L++ N K + + L+ L+ L + N
Sbjct: 39 CRC--DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN 96
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + ++A + L+ L LS N ++L+ N P +L+ LDLS+NK QT L
Sbjct: 97 YISSVDEDAFQGIRRLKELILSSNKI-TYLH---NKTFHPVPNLRNLDLSYNKLQT---L 149
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPL---SGLINIRVLKLNFNPLLRI-QNLISS- 210
+++ L LI+ H NS+ P+ N+ L L +N L + +N +
Sbjct: 150 QSEQF---KGLRKLIILHLRSNSLK-TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGL 205
Query: 211 -SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + + + +N L +L + + N R+ S SL +D+S
Sbjct: 206 LKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWN-RIRSISQGLTWTWSSLHNLDLSGN 264
Query: 270 NI--LQP-NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+I ++P K P+L+K L+ N + + L + LS N
Sbjct: 265 DIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 312
>BC041374-1|AAH41374.3| 640|Homo sapiens LRRC4C protein protein.
Length = 640
Score = 73.3 bits (172), Expect = 3e-12
Identities = 62/204 (30%), Positives = 94/204 (46%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N +R +E AF L L+L +N + ++ F L LK L L N I IP
Sbjct: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L +Y+S ++ L+++ C L I +L L + EL
Sbjct: 167 AFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREI--PNLTPLIKLDEL 224
Query: 403 DLSQNLLSYI-PDSISSNT-LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
DLS N LS I P S L+ L + ++I I F L L +++ N T++
Sbjct: 225 DLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLL-P 283
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F +LER+ L N W C+C
Sbjct: 284 HDLFTPLHHLERIHLHHNPWNCNC 307
Score = 72.5 bits (170), Expect = 5e-12
Identities = 55/196 (28%), Positives = 99/196 (50%), Gaps = 5/196 (2%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N ++ ++ N+F + LE L LS N+I ++ F GL L L+L N + IP
Sbjct: 83 LHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNG 142
Query: 347 SLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSCE-LNTIGKDSLEGLQSIVEL 402
+ + + L +L L N + + R S+ LD+ + L+ I + + EGL ++ L
Sbjct: 143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYL 202
Query: 403 DLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRS 462
+L+ L IP+ L L+L+ N +S+I +F L L L ++ ++ +I R+
Sbjct: 203 NLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVI-ERN 261
Query: 463 FFDSNPYLERLDLSDN 478
FD+ L ++L+ N
Sbjct: 262 AFDNLQSLVEINLAHN 277
Score = 64.5 bits (150), Expect = 1e-09
Identities = 71/261 (27%), Positives = 113/261 (43%), Gaps = 15/261 (5%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISS 94
+C C+ + + C R+ L ++P+G+ LN+ N+ S L +L L +S
Sbjct: 50 VCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSR 109
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N ++ + A L L L L FD+ L PN + + LK L L N +++ +
Sbjct: 110 NHIRTIEIGAFNGLANLNTLEL----FDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPS 165
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS-SSLR 213
A + PSL L L + S GL N+R L L L I NL L
Sbjct: 166 YAFNRI---PSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLD 222
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCNI- 271
L +S L+++ L L L M + + +A +NL QSL I++++ N+
Sbjct: 223 ELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNL--QSLVEINLAHNNLT 280
Query: 272 LQPNLKGFP--SLRKAILNHN 290
L P+ P L + L+HN
Sbjct: 281 LLPHDLFTPLHHLERIHLHHN 301
Score = 64.1 bits (149), Expect = 2e-09
Identities = 60/237 (25%), Positives = 114/237 (48%), Gaps = 10/237 (4%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ- 259
L + + IS++ R L + ++ + N L L L++S N+ + A N +
Sbjct: 67 LREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANL 126
Query: 260 -SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIA 317
+L+ D I L++ L +N + + S AF L LDL ++
Sbjct: 127 NTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLS 186
Query: 318 SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS--RVGHLRS-MS 374
+ F GL L++L+L+ + IP +L + L +L LS N+LS R G + M
Sbjct: 187 YISEGAFEGLSNLRYLNLAMCNLREIP--NLTPLIKLDELDLSGNHLSAIRPGSFQGLMH 244
Query: 375 VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYN 429
+ L M ++ I +++ + LQS+VE++L+ N L+ +P + + + L+ ++L++N
Sbjct: 245 LQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
Score = 53.2 bits (122), Expect = 3e-06
Identities = 60/231 (25%), Positives = 103/231 (44%), Gaps = 32/231 (13%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
+T+ ++L+L N+ Q + N +R LE L L I +I +GL N+ L+
Sbjct: 75 STNTRLLNLHENQIQIIK--VNSFKHLR-HLEILQLSRNHIRTIE-IGAFNGLANLNTLE 130
Query: 196 LNFNPLLRIQN---LISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASS 252
L N L I N + S L+ L++ N + S+ +PSL L + RL S
Sbjct: 131 LFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISE 190
Query: 253 ANNLFSQSLKYIDISYCNILQ-PNL------------------------KGFPSLRKAIL 287
+L+Y++++ CN+ + PNL +G L+K +
Sbjct: 191 GAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWM 250
Query: 288 NHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+ ++ +E NAF N L ++L++NN+ L +D F L L+ + L N
Sbjct: 251 IQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
>AY358324-1|AAQ88690.1| 590|Homo sapiens GFHL3075 protein.
Length = 590
Score = 73.3 bits (172), Expect = 3e-12
Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N ++ L+SN FA +L +L L +N I+S+ D F+G++ LK L LS N+I +
Sbjct: 68 LRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNK 127
Query: 347 SLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ +P+L L LS N L + + + + IL + S L T+ + +++ LD
Sbjct: 128 TFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLD 187
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L N L + + + LK L+L +N+ S IN F L L S+ + NR I +
Sbjct: 188 LGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG 247
Query: 462 SFFDSNPYLERLDLSDN 478
+ + L LDLS N
Sbjct: 248 LTWTWSS-LHNLDLSGN 263
Score = 70.1 bits (164), Expect = 3e-11
Identities = 55/175 (31%), Positives = 87/175 (49%), Gaps = 10/175 (5%)
Query: 294 YLESNAFANNTE-----LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
Y ES+AFA+ E + L L N+I L+ + F GL L L L N I+ + ED+
Sbjct: 46 YCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAF 105
Query: 349 LEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+ L +L LS N YL ++ LD+S +L T+ + +GL+ ++ L L
Sbjct: 106 QGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLR 165
Query: 406 QNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
N L +P + L +L+L YNR+ S++ F L +L L + N+F+ I
Sbjct: 166 SNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKI 220
Score = 69.7 bits (163), Expect = 3e-11
Identities = 68/261 (26%), Positives = 118/261 (45%), Gaps = 12/261 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D +Y + + + +G L++ IL+ N + YL + F L LDLS N + +L+
Sbjct: 91 YLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTIL 378
+ F+GL+ L L L N + +P + +L L L N LSR + + L
Sbjct: 151 EQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKEL 210
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINN 436
+ + + I L ++ + L N + I + + ++L L+L+ N I I
Sbjct: 211 HLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEP 270
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFV 496
TF L L L++ N+ T I + + ++ L + LS NMW +CS FY
Sbjct: 271 GTFKCLPNLQKLNLDSNKLTNISQET-VNAWISLISITLSGNMW--ECSRSICPLFYWLK 327
Query: 497 TLEPNKKEESFNLICNSPANV 517
+ NK+ +IC P ++
Sbjct: 328 NFKGNKES---TMICAGPKHI 345
Score = 53.2 bits (122), Expect = 3e-06
Identities = 71/288 (24%), Positives = 124/288 (43%), Gaps = 24/288 (8%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSN 95
CRC D + C DIP + L++ N K + + L+ L+ L + N
Sbjct: 38 CRC--DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + ++A + L+ L LS N ++L+ N P +L+ LDLS+NK QT L
Sbjct: 96 YISSVDEDAFQGIRRLKELILSSNKI-TYLH---NKTFHPVPNLRNLDLSYNKLQT---L 148
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPL---SGLINIRVLKLNFNPLLRI-QNLISS- 210
+++ L LI+ H NS+ P+ N+ L L +N L + +N +
Sbjct: 149 QSEQF---KGLRKLIILHLRSNSLK-TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGL 204
Query: 211 -SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + + + +N L +L + + N R+ S SL +D+S
Sbjct: 205 LKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWN-RIRSISQGLTWTWSSLHNLDLSGN 263
Query: 270 NI--LQP-NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+I ++P K P+L+K L+ N + + L + LS N
Sbjct: 264 DIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
>AY358296-1|AAQ88663.1| 1041|Homo sapiens TLR8 protein.
Length = 1041
Score = 73.3 bits (172), Expect = 3e-12
Identities = 120/501 (23%), Positives = 215/501 (42%), Gaps = 67/501 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL--- 97
D +CS R L ++P +G VT+L++S+N T ES L NL ++++ N
Sbjct: 43 DSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH 102
Query: 98 ----KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
G+ N L N+T LNL +N + L N + + +LS + +
Sbjct: 103 QNGNPGIQSNGL-NITDGAFLNL-KNLRELLLEDNQLPQIPSGLPESLTELSLIQ-NNIY 159
Query: 154 NLANQELLIRPSLETLILD-HCEINSIHGRSPLSG-----LINIRVLKLNFNPLLRIQNL 207
N+ + + +L+ L L +C N + ++ + L N+ +L L+FN L +
Sbjct: 160 NITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPK 219
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN-----------YRLELASSAN-N 255
+ SSLR LF+SN ++ ++ + L +LT L +S N + +S N +
Sbjct: 220 LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINID 279
Query: 256 LFS----QSLKYIDISYCNILQPN---LKGFPSLRKAILNHN-MVRYLESNAFANN-TEL 306
F+ L+Y+++S ++ + N K P L+ L N +V + S AF L
Sbjct: 280 RFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIVSGAFLTMLPRL 339
Query: 307 EYLDLSNNNIASLRYD------TFRGLKMLKHLDLSWNEIAVIPEDS---LLEMPSLTQL 357
E LDLS N I F L L+ L L + ED L+++P+L+ +
Sbjct: 340 EILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTI 399
Query: 358 KLSRNYLSRVGH--LRSMS-VTILDMSSCELNTIGKDSLEGL--------------QSIV 400
L N++ ++ ++ S + I+ +S ++ + KD+ + +
Sbjct: 400 NLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF 459
Query: 401 ELDLSQNLLSYIPDSISSNTLKY---LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTM 457
E D N + I Y L+L+ N I I F L + L++ N
Sbjct: 460 EFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 519
Query: 458 IWRRSFFDSNPYLERLDLSDN 478
+ + F + P+++ LDL++N
Sbjct: 520 VLSGTEFSAIPHVKYLDLTNN 540
Score = 63.3 bits (147), Expect = 3e-09
Identities = 100/415 (24%), Positives = 189/415 (45%), Gaps = 36/415 (8%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+ L L L++SS L+ + N+ L+VL+L NY + +LP L
Sbjct: 282 AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIVSGAFLTMLP--RL 339
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ILDLSFN + G+ Q + I + L+ + ++H L G + + + +F
Sbjct: 340 EILDLSFNYIK--GSYP-QHINISRNFSKLL----SLRALH----LRGYVFQELREDDFQ 388
Query: 200 PLLRIQNLISSSLRSLFVSNCELT---SLNHNELMFLPSLTHLKMSNNYRLELASSAN-N 255
PL+++ NL + +L F+ + + ++ E+++L + + R A+S++
Sbjct: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 448
Query: 256 LFSQSLKYIDI------SYCNILQPNLKG-FPSLRKAI-LNHNMVRYLESNAFANNTELE 307
+ + D ++ + +P +K + KA+ L+ N + ++ N F N ++
Sbjct: 449 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA 508
Query: 308 YLDLSNNNIASLRYDT-FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN-YLS 365
L+LS N+ A + T F + +K+LDL+ N + +L E+ L L LS N +
Sbjct: 509 CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYF 568
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL- 424
R+ + I + ++ ++ + +++ L L+ S++L+ + S N L L
Sbjct: 569 RIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE-SKSLVELV---FSGNRLDILW 624
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N + NR SI F L LT L + NR I +F + L L ++DNM
Sbjct: 625 NDDDNRYISI----FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM 675
Score = 62.5 bits (145), Expect = 5e-09
Identities = 130/476 (27%), Positives = 195/476 (40%), Gaps = 70/476 (14%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLK------ 98
+ S L+ +P L + KL +SN + E L NL LD+S N +
Sbjct: 206 LSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPF 265
Query: 99 -------GLPDN----ALYNLTALEVLNLS----RNYFDSWLNLNPNDVLLPATHLKILD 143
G N A NLT L LNLS R +W P HLK+LD
Sbjct: 266 PCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMP--------HLKVLD 317
Query: 144 LSFNKFQTMGNLANQELL-IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLL 202
L FN +G + + L + P LE L L N I G P INI NF+ LL
Sbjct: 318 LEFNYL--VGEIVSGAFLTMLPRLEILDLS---FNYIKGSYPQH--INI---SRNFSKLL 367
Query: 203 RIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLK 262
++ L LR EL + LM LP+L+ + + N+ ++ FS +L+
Sbjct: 368 SLRAL---HLRGYVFQ--ELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFS-NLE 421
Query: 263 YIDISYCNILQPNLKGFPSLRKAILNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRY 321
I +S N + P +K R++ N + R++ +T+ E+ SN +
Sbjct: 422 IIYLSE-NRISPLVK---DTRQSYANSSSFQRHIRKR---RSTDFEFDPHSNFYHFTRPL 474
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMS----VTI 377
+ K LDLS N I I + +P + L LS N ++V S V
Sbjct: 475 IKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKY 534
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNL-------LSYIPDSISSNT-LKYLNLNYN 429
LD+++ L+ +L L + LDLS N +++ + I + T LK LNL++N
Sbjct: 535 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHN 594
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
I ++ + L L GNR ++W D N Y+ N+ R D S
Sbjct: 595 NIYTLTDKYNLESKSLVELVFSGNRLDILWND---DDNRYISIFKGLKNLTRLDLS 647
Score = 62.5 bits (145), Expect = 5e-09
Identities = 114/446 (25%), Positives = 183/446 (41%), Gaps = 41/446 (9%)
Query: 63 QVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKG--LPDNALYNLTALEVLNLSRN 119
Q+ LN+S+ K + + +L LD+ N L G + L L LE+L+LS N
Sbjct: 288 QLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIVSGAFLTMLPRLEILDLSFN 347
Query: 120 Y----FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
Y + +N++ N L + L+ L L FQ + Q L+ P+L T+ L
Sbjct: 348 YIKGSYPQHINISRNFSKLLS--LRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINF 405
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
I I + N+ ++ L+ N RI L+ + +S S+ +
Sbjct: 406 IKQIDFKL-FQNFSNLEIIYLSEN---RISPLVKDTRQSYANSSSFQRHIRKRRSTDFEF 461
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI--LQPN-LKGFPSLRKAILNHNM- 291
H SN Y + K +D+S +I + PN + P + L+ N
Sbjct: 462 DPH---SNFYHFTRPLIKPQCAAYG-KALDLSLNSIFFIGPNQFENLPDIACLNLSANSN 517
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE----IAVIPE-- 345
+ L F+ ++YLDL+NN + L L+ LDLS+N IA +
Sbjct: 518 AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHL 577
Query: 346 DSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDS-------LEG 395
+ + +L L LS N + + +L S S+ L S L+ + D +G
Sbjct: 578 EFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKG 637
Query: 396 LQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
L+++ LDLS N L +IP+ N +L L++N N + N RL L + G
Sbjct: 638 LKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRG 697
Query: 453 NRFTMIWRRSFFDSNPYLERLDLSDN 478
N+ + S D L L LS N
Sbjct: 698 NKLLFL-TDSLSDFTSSLRTLLLSHN 722
Score = 60.5 bits (140), Expect = 2e-08
Identities = 87/303 (28%), Positives = 124/303 (40%), Gaps = 24/303 (7%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + N NL + LNLS N L+ + H+K LDL+ N+
Sbjct: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAI---PHVKYLDLTNNRL 542
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRIQ-- 205
A EL L+ H I + H + N++VL L+ N + +
Sbjct: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
Query: 206 -NLISSSLRSLFVSNCELTSL-NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
NL S SL L S L L N ++ ++ LK N RL+L S N L K+
Sbjct: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLK--NLTRLDL--SLNRL-----KH 653
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
I N NL SL + +N NM+++ LE LDL N + L
Sbjct: 654 IP----NEAFLNLPA--SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL 707
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSC 383
L+ L LS N I+ +P L E+ SL L LS N L + + T +S
Sbjct: 708 SDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 767
Query: 384 ELN 386
EL+
Sbjct: 768 ELH 770
Score = 55.6 bits (128), Expect = 6e-07
Identities = 74/265 (27%), Positives = 122/265 (46%), Gaps = 21/265 (7%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN--YFDSW 124
L+ ++N S + ++ LD+++N+L +AL L+ LEVL+LS N YF
Sbjct: 512 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA 571
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEI----NSIH 180
+ + + T+LK+L+LS N T+ + N E SL L+ + N
Sbjct: 572 GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE---SKSLVELVFSGNRLDILWNDDD 628
Query: 181 GR--SPLSGLINIRVLKLNFNPLLRIQN----LISSSLRSLFVSNCELTSLNHNELMFLP 234
R S GL N+ L L+ N L I N + +SL L +++ L N L P
Sbjct: 629 NRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFP 688
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PN--LKGFPSLRKAILNHNM 291
L L + N L L S ++ F+ SL+ + +S+ I P+ L SL+ L+ N+
Sbjct: 689 RLELLDLRGNKLLFLTDSLSD-FTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 747
Query: 292 VRYLESNAF--ANNTELEYLDLSNN 314
++ + +A T+L L+L N
Sbjct: 748 LKTINKSALETKTTTKLSMLELHGN 772
Score = 42.3 bits (95), Expect = 0.006
Identities = 74/288 (25%), Positives = 127/288 (44%), Gaps = 21/288 (7%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
A + K LDLS N +G + L P + L L + + S + +++ L
Sbjct: 480 AAYGKALDLSLNSIFFIGPNQFENL---PDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 536
Query: 196 LNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLTH-LKMSNNY-RLELAS- 251
L N L N +S+L L S+ E+ L++N F + +TH L+ N+ L++ +
Sbjct: 537 LT-NNRLDFDN--ASALTEL--SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNL 591
Query: 252 SANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL 311
S NN+++ + KY ++ ++++ G + + N + RY+ + F L LDL
Sbjct: 592 SHNNIYTLTDKY-NLESKSLVELVFSG--NRLDILWNDDDNRYI--SIFKGLKNLTRLDL 646
Query: 312 SNNNIASLRYDTFRGLKM-LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL 370
S N + + + F L L L ++ N + L + P L L L N L +
Sbjct: 647 SLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDS 706
Query: 371 RS---MSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS 415
S S+ L +S ++ + L + S+ LDLS NLL I S
Sbjct: 707 LSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 754
>AY358293-1|AAQ88660.1| 640|Homo sapiens LNKM292 protein.
Length = 640
Score = 73.3 bits (172), Expect = 3e-12
Identities = 62/204 (30%), Positives = 94/204 (46%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N +R +E AF L L+L +N + ++ F L LK L L N I IP
Sbjct: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L +Y+S ++ L+++ C L I +L L + EL
Sbjct: 167 AFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREI--PNLTPLIKLDEL 224
Query: 403 DLSQNLLSYI-PDSISSNT-LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
DLS N LS I P S L+ L + ++I I F L L +++ N T++
Sbjct: 225 DLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLL-P 283
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F +LER+ L N W C+C
Sbjct: 284 HDLFTPLHHLERIHLHHNPWNCNC 307
Score = 72.5 bits (170), Expect = 5e-12
Identities = 55/196 (28%), Positives = 99/196 (50%), Gaps = 5/196 (2%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N ++ ++ N+F + LE L LS N+I ++ F GL L L+L N + IP
Sbjct: 83 LHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNG 142
Query: 347 SLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSCE-LNTIGKDSLEGLQSIVEL 402
+ + + L +L L N + + R S+ LD+ + L+ I + + EGL ++ L
Sbjct: 143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYL 202
Query: 403 DLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRS 462
+L+ L IP+ L L+L+ N +S+I +F L L L ++ ++ +I R+
Sbjct: 203 NLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVI-ERN 261
Query: 463 FFDSNPYLERLDLSDN 478
FD+ L ++L+ N
Sbjct: 262 AFDNLQSLVEINLAHN 277
Score = 64.5 bits (150), Expect = 1e-09
Identities = 71/261 (27%), Positives = 113/261 (43%), Gaps = 15/261 (5%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISS 94
+C C+ + + C R+ L ++P+G+ LN+ N+ S L +L L +S
Sbjct: 50 VCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSR 109
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N ++ + A L L L L FD+ L PN + + LK L L N +++ +
Sbjct: 110 NHIRTIEIGAFNGLANLNTLEL----FDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPS 165
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS-SSLR 213
A + PSL L L + S GL N+R L L L I NL L
Sbjct: 166 YAFNRI---PSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLD 222
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCNI- 271
L +S L+++ L L L M + + +A +NL QSL I++++ N+
Sbjct: 223 ELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNL--QSLVEINLAHNNLT 280
Query: 272 LQPNLKGFP--SLRKAILNHN 290
L P+ P L + L+HN
Sbjct: 281 LLPHDLFTPLHHLERIHLHHN 301
Score = 64.1 bits (149), Expect = 2e-09
Identities = 60/237 (25%), Positives = 114/237 (48%), Gaps = 10/237 (4%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ- 259
L + + IS++ R L + ++ + N L L L++S N+ + A N +
Sbjct: 67 LREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANL 126
Query: 260 -SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIA 317
+L+ D I L++ L +N + + S AF L LDL ++
Sbjct: 127 NTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLS 186
Query: 318 SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS--RVGHLRS-MS 374
+ F GL L++L+L+ + IP +L + L +L LS N+LS R G + M
Sbjct: 187 YISEGAFEGLSNLRYLNLAMCNLREIP--NLTPLIKLDELDLSGNHLSAIRPGSFQGLMH 244
Query: 375 VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYN 429
+ L M ++ I +++ + LQS+VE++L+ N L+ +P + + + L+ ++L++N
Sbjct: 245 LQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
Score = 53.2 bits (122), Expect = 3e-06
Identities = 60/231 (25%), Positives = 103/231 (44%), Gaps = 32/231 (13%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
+T+ ++L+L N+ Q + N +R LE L L I +I +GL N+ L+
Sbjct: 75 STNTRLLNLHENQIQIIK--VNSFKHLR-HLEILQLSRNHIRTIE-IGAFNGLANLNTLE 130
Query: 196 LNFNPLLRIQN---LISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASS 252
L N L I N + S L+ L++ N + S+ +PSL L + RL S
Sbjct: 131 LFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISE 190
Query: 253 ANNLFSQSLKYIDISYCNILQ-PNL------------------------KGFPSLRKAIL 287
+L+Y++++ CN+ + PNL +G L+K +
Sbjct: 191 GAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWM 250
Query: 288 NHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+ ++ +E NAF N L ++L++NN+ L +D F L L+ + L N
Sbjct: 251 IQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
>AY182030-1|AAO67551.1| 518|Homo sapiens leucine-rich repeat
transmembrane neuronal 4 protein protein.
Length = 518
Score = 73.3 bits (172), Expect = 3e-12
Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N ++ L+SN FA +L +L L +N I+S+ D F+G++ LK L LS N+I +
Sbjct: 68 LRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNK 127
Query: 347 SLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ +P+L L LS N L + + + + IL + S L T+ + +++ LD
Sbjct: 128 TFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLD 187
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L N L + + + LK L+L +N+ S IN F L L S+ + NR I +
Sbjct: 188 LGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG 247
Query: 462 SFFDSNPYLERLDLSDN 478
+ + L LDLS N
Sbjct: 248 LTWTWSS-LHNLDLSGN 263
Score = 70.1 bits (164), Expect = 3e-11
Identities = 55/175 (31%), Positives = 87/175 (49%), Gaps = 10/175 (5%)
Query: 294 YLESNAFANNTE-----LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
Y ES+AFA+ E + L L N+I L+ + F GL L L L N I+ + ED+
Sbjct: 46 YCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAF 105
Query: 349 LEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+ L +L LS N YL ++ LD+S +L T+ + +GL+ ++ L L
Sbjct: 106 QGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLR 165
Query: 406 QNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
N L +P + L +L+L YNR+ S++ F L +L L + N+F+ I
Sbjct: 166 SNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKI 220
Score = 69.7 bits (163), Expect = 3e-11
Identities = 68/261 (26%), Positives = 118/261 (45%), Gaps = 12/261 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D +Y + + + +G L++ IL+ N + YL + F L LDLS N + +L+
Sbjct: 91 YLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTIL 378
+ F+GL+ L L L N + +P + +L L L N LSR + + L
Sbjct: 151 EQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKEL 210
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINN 436
+ + + I L ++ + L N + I + + ++L L+L+ N I I
Sbjct: 211 HLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEP 270
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFV 496
TF L L L++ N+ T I + + ++ L + LS NMW +CS FY
Sbjct: 271 GTFKCLPNLQKLNLDSNKLTNISQET-VNAWISLISITLSGNMW--ECSRSICPLFYWLK 327
Query: 497 TLEPNKKEESFNLICNSPANV 517
+ NK+ +IC P ++
Sbjct: 328 NFKGNKES---TMICAGPKHI 345
Score = 53.2 bits (122), Expect = 3e-06
Identities = 71/288 (24%), Positives = 124/288 (43%), Gaps = 24/288 (8%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSN 95
CRC D + C DIP + L++ N K + + L+ L+ L + N
Sbjct: 38 CRC--DGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + ++A + L+ L LS N ++L+ N P +L+ LDLS+NK QT L
Sbjct: 96 YISSVDEDAFQGIRRLKELILSSNKI-TYLH---NKTFHPVPNLRNLDLSYNKLQT---L 148
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPL---SGLINIRVLKLNFNPLLRI-QNLISS- 210
+++ L LI+ H NS+ P+ N+ L L +N L + +N +
Sbjct: 149 QSEQF---KGLRKLIILHLRSNSLK-TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGL 204
Query: 211 -SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + + + +N L +L + + N R+ S SL +D+S
Sbjct: 205 LKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWN-RIRSISQGLTWTWSSLHNLDLSGN 263
Query: 270 NI--LQP-NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+I ++P K P+L+K L+ N + + L + LS N
Sbjct: 264 DIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
>AL157827-4|CAI12589.1| 699|Homo sapiens extracellular matrix
protein 2, female organ and adipocyte specific protein.
Length = 699
Score = 73.3 bits (172), Expect = 3e-12
Identities = 93/343 (27%), Positives = 148/343 (43%), Gaps = 30/343 (8%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL 97
C+L I C LT IP Q+T L ++ N P E+ + L NL LD+S N +
Sbjct: 320 CSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNI 379
Query: 98 --KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG-- 153
G+ A L L LN+ N NL LP+T L+ L ++ N Q +
Sbjct: 380 TSSGIGPKAFKLLKKLMRLNMDGN------NLIQIPSQLPST-LEELKVNENNLQAIDEE 432
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+L++ L+ LE L +N + PL L +R+ K N I + S+
Sbjct: 433 SLSDLNQLVTLELEGNNLSEANVNPL-AFKPLKSLAYLRLGK---NKFRIIPQGLPGSIE 488
Query: 214 SLFVSNCELTSL-----NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
L++ N ++ + NH + + L + K+ N LA + ++L+ ID+SY
Sbjct: 489 ELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAW----INQENLESIDLSY 544
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFAN-NTELEYLDLSNNNIASLRYD--TFR 325
+ SL +L N + + F + LEYL LS N +A D +F
Sbjct: 545 NKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFY 604
Query: 326 G-LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
G L+ L L N++ IP + EM +L L+L+ N + +
Sbjct: 605 GAYHSLRELFLDHNDLKSIP-PGIQEMKALHFLRLNNNKIRNI 646
Score = 48.0 bits (109), Expect = 1e-04
Identities = 33/108 (30%), Positives = 56/108 (51%), Gaps = 2/108 (1%)
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI--AVIPEDSLLEMPSLTQLKLSRN 362
++ L+L+ N+IAS+ + F GL L+ LDLS N I + I + + L +L + N
Sbjct: 344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGN 403
Query: 363 YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLS 410
L ++ ++ L ++ L I ++SL L +V L+L N LS
Sbjct: 404 NLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 451
Score = 46.8 bits (106), Expect = 3e-04
Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 20/124 (16%)
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDS 392
L+L+ N IA IP+++ +P+L +L LS+N ++ G IG +
Sbjct: 348 LELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSG-------------------IGPKA 388
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
+ L+ ++ L++ N L IP + S TL+ L +N N + +I+ + LN+L +L + G
Sbjct: 389 FKLLKKLMRLNMDGNNLIQIPSQLPS-TLEELKVNENNLQAIDEESLSDLNQLVTLELEG 447
Query: 453 NRFT 456
N +
Sbjct: 448 NNLS 451
>AL137848-1|CAI16693.1| 699|Homo sapiens extracellular matrix
protein 2, female organ and adipocyte specific protein.
Length = 699
Score = 73.3 bits (172), Expect = 3e-12
Identities = 93/343 (27%), Positives = 148/343 (43%), Gaps = 30/343 (8%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL 97
C+L I C LT IP Q+T L ++ N P E+ + L NL LD+S N +
Sbjct: 320 CSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNI 379
Query: 98 --KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG-- 153
G+ A L L LN+ N NL LP+T L+ L ++ N Q +
Sbjct: 380 TSSGIGPKAFKLLKKLMRLNMDGN------NLIQIPSQLPST-LEELKVNENNLQAIDEE 432
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+L++ L+ LE L +N + PL L +R+ K N I + S+
Sbjct: 433 SLSDLNQLVTLELEGNNLSEANVNPL-AFKPLKSLAYLRLGK---NKFRIIPQGLPGSIE 488
Query: 214 SLFVSNCELTSL-----NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
L++ N ++ + NH + + L + K+ N LA + ++L+ ID+SY
Sbjct: 489 ELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAW----INQENLESIDLSY 544
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFAN-NTELEYLDLSNNNIASLRYD--TFR 325
+ SL +L N + + F + LEYL LS N +A D +F
Sbjct: 545 NKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFY 604
Query: 326 G-LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
G L+ L L N++ IP + EM +L L+L+ N + +
Sbjct: 605 GAYHSLRELFLDHNDLKSIP-PGIQEMKALHFLRLNNNKIRNI 646
Score = 48.0 bits (109), Expect = 1e-04
Identities = 33/108 (30%), Positives = 56/108 (51%), Gaps = 2/108 (1%)
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI--AVIPEDSLLEMPSLTQLKLSRN 362
++ L+L+ N+IAS+ + F GL L+ LDLS N I + I + + L +L + N
Sbjct: 344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGN 403
Query: 363 YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLS 410
L ++ ++ L ++ L I ++SL L +V L+L N LS
Sbjct: 404 NLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 451
Score = 46.8 bits (106), Expect = 3e-04
Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 20/124 (16%)
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDS 392
L+L+ N IA IP+++ +P+L +L LS+N ++ G IG +
Sbjct: 348 LELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSG-------------------IGPKA 388
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
+ L+ ++ L++ N L IP + S TL+ L +N N + +I+ + LN+L +L + G
Sbjct: 389 FKLLKKLMRLNMDGNNLIQIPSQLPS-TLEELKVNENNLQAIDEESLSDLNQLVTLELEG 447
Query: 453 NRFT 456
N +
Sbjct: 448 NNLS 451
>AK126961-1|BAC86764.1| 518|Homo sapiens protein ( Homo sapiens
cDNA FLJ45014 fis, clone BRAWH3014609. ).
Length = 518
Score = 73.3 bits (172), Expect = 3e-12
Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 6/197 (3%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N ++ L+SN FA +L +L L +N I+S+ D F+G++ LK L LS N+I +
Sbjct: 68 LRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNK 127
Query: 347 SLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELD 403
+ +P+L L LS N L + + + + IL + S L T+ + +++ LD
Sbjct: 128 TFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLD 187
Query: 404 LSQNLLSYIPDSISSNTLKY--LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L N L + + + LK L+L +N+ S IN F L L S+ + NR I +
Sbjct: 188 LGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQG 247
Query: 462 SFFDSNPYLERLDLSDN 478
+ + L LDLS N
Sbjct: 248 LTWTWSS-LHNLDLSGN 263
Score = 69.7 bits (163), Expect = 3e-11
Identities = 55/175 (31%), Positives = 86/175 (49%), Gaps = 10/175 (5%)
Query: 294 YLESNAFANNTE-----LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSL 348
Y ES+AFA E + L L N+I L+ + F GL L L L N I+ + ED+
Sbjct: 46 YCESHAFAGIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAF 105
Query: 349 LEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
+ L +L LS N YL ++ LD+S +L T+ + +GL+ ++ L L
Sbjct: 106 QGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLR 165
Query: 406 QNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMI 458
N L +P + L +L+L YNR+ S++ F L +L L + N+F+ I
Sbjct: 166 SNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKI 220
Score = 69.7 bits (163), Expect = 3e-11
Identities = 68/261 (26%), Positives = 118/261 (45%), Gaps = 12/261 (4%)
Query: 263 YIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRY 321
Y+D +Y + + + +G L++ IL+ N + YL + F L LDLS N + +L+
Sbjct: 91 YLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQS 150
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTIL 378
+ F+GL+ L L L N + +P + +L L L N LSR + + L
Sbjct: 151 EQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKEL 210
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINN 436
+ + + I L ++ + L N + I + + ++L L+L+ N I I
Sbjct: 211 HLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEP 270
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFV 496
TF L L L++ N+ T I + + ++ L + LS NMW +CS FY
Sbjct: 271 GTFKCLPNLQKLNLDSNKLTNISQET-VNAWISLISITLSGNMW--ECSRSICPLFYWLK 327
Query: 497 TLEPNKKEESFNLICNSPANV 517
+ NK+ +IC P ++
Sbjct: 328 NFKGNKES---TMICAGPKHI 345
Score = 50.4 bits (115), Expect = 2e-05
Identities = 70/288 (24%), Positives = 123/288 (42%), Gaps = 24/288 (8%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSN 95
CRC D + C IP + L++ N K + + L+ L+ L + N
Sbjct: 38 CRC--DGKIVYCESHAFAGIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN 95
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
+ + ++A + L+ L LS N ++L+ N P +L+ LDLS+NK QT L
Sbjct: 96 YISSVDEDAFQGIRRLKELILSSNKI-TYLH---NKTFHPVPNLRNLDLSYNKLQT---L 148
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPL---SGLINIRVLKLNFNPLLRI-QNLISS- 210
+++ L LI+ H NS+ P+ N+ L L +N L + +N +
Sbjct: 149 QSEQF---KGLRKLIILHLRSNSLK-TVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGL 204
Query: 211 -SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + + + +N L +L + + N R+ S SL +D+S
Sbjct: 205 LKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWN-RIRSISQGLTWTWSSLHNLDLSGN 263
Query: 270 NI--LQP-NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNN 314
+I ++P K P+L+K L+ N + + L + LS N
Sbjct: 264 DIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
>AB046800-1|BAB13406.1| 640|Homo sapiens KIAA1580 protein protein.
Length = 640
Score = 73.3 bits (172), Expect = 3e-12
Identities = 62/204 (30%), Positives = 94/204 (46%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N +R +E AF L L+L +N + ++ F L LK L L N I IP
Sbjct: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L +Y+S ++ L+++ C L I +L L + EL
Sbjct: 167 AFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREI--PNLTPLIKLDEL 224
Query: 403 DLSQNLLSYI-PDSISSNT-LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
DLS N LS I P S L+ L + ++I I F L L +++ N T++
Sbjct: 225 DLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLL-P 283
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F +LER+ L N W C+C
Sbjct: 284 HDLFTPLHHLERIHLHHNPWNCNC 307
Score = 72.5 bits (170), Expect = 5e-12
Identities = 55/196 (28%), Positives = 99/196 (50%), Gaps = 5/196 (2%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N ++ ++ N+F + LE L LS N+I ++ F GL L L+L N + IP
Sbjct: 83 LHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNG 142
Query: 347 SLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSCE-LNTIGKDSLEGLQSIVEL 402
+ + + L +L L N + + R S+ LD+ + L+ I + + EGL ++ L
Sbjct: 143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYL 202
Query: 403 DLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRS 462
+L+ L IP+ L L+L+ N +S+I +F L L L ++ ++ +I R+
Sbjct: 203 NLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVI-ERN 261
Query: 463 FFDSNPYLERLDLSDN 478
FD+ L ++L+ N
Sbjct: 262 AFDNLQSLVEINLAHN 277
Score = 64.5 bits (150), Expect = 1e-09
Identities = 71/261 (27%), Positives = 113/261 (43%), Gaps = 15/261 (5%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISS 94
+C C+ + + C R+ L ++P+G+ LN+ N+ S L +L L +S
Sbjct: 50 VCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSR 109
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N ++ + A L L L L FD+ L PN + + LK L L N +++ +
Sbjct: 110 NHIRTIEIGAFNGLANLNTLEL----FDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPS 165
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS-SSLR 213
A + PSL L L + S GL N+R L L L I NL L
Sbjct: 166 YAFNRI---PSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLD 222
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCNI- 271
L +S L+++ L L L M + + +A +NL QSL I++++ N+
Sbjct: 223 ELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNL--QSLVEINLAHNNLT 280
Query: 272 LQPNLKGFP--SLRKAILNHN 290
L P+ P L + L+HN
Sbjct: 281 LLPHDLFTPLHHLERIHLHHN 301
Score = 64.1 bits (149), Expect = 2e-09
Identities = 60/237 (25%), Positives = 114/237 (48%), Gaps = 10/237 (4%)
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ- 259
L + + IS++ R L + ++ + N L L L++S N+ + A N +
Sbjct: 67 LREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANL 126
Query: 260 -SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIA 317
+L+ D I L++ L +N + + S AF L LDL ++
Sbjct: 127 NTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLS 186
Query: 318 SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS--RVGHLRS-MS 374
+ F GL L++L+L+ + IP +L + L +L LS N+LS R G + M
Sbjct: 187 YISEGAFEGLSNLRYLNLAMCNLREIP--NLTPLIKLDELDLSGNHLSAIRPGSFQGLMH 244
Query: 375 VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYN 429
+ L M ++ I +++ + LQS+VE++L+ N L+ +P + + + L+ ++L++N
Sbjct: 245 LQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
Score = 53.2 bits (122), Expect = 3e-06
Identities = 60/231 (25%), Positives = 103/231 (44%), Gaps = 32/231 (13%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
+T+ ++L+L N+ Q + N +R LE L L I +I +GL N+ L+
Sbjct: 75 STNTRLLNLHENQIQIIK--VNSFKHLR-HLEILQLSRNHIRTIE-IGAFNGLANLNTLE 130
Query: 196 LNFNPLLRIQN---LISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASS 252
L N L I N + S L+ L++ N + S+ +PSL L + RL S
Sbjct: 131 LFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISE 190
Query: 253 ANNLFSQSLKYIDISYCNILQ-PNL------------------------KGFPSLRKAIL 287
+L+Y++++ CN+ + PNL +G L+K +
Sbjct: 191 GAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWM 250
Query: 288 NHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+ ++ +E NAF N L ++L++NN+ L +D F L L+ + L N
Sbjct: 251 IQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
>AB011792-1|BAA33958.1| 699|Homo sapiens extracellular matrix
protein protein.
Length = 699
Score = 73.3 bits (172), Expect = 3e-12
Identities = 93/343 (27%), Positives = 148/343 (43%), Gaps = 30/343 (8%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL 97
C+L I C LT IP Q+T L ++ N P E+ + L NL LD+S N +
Sbjct: 320 CSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNI 379
Query: 98 --KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG-- 153
G+ A L L LN+ N NL LP+T L+ L ++ N Q +
Sbjct: 380 TSSGIGPKAFKLLKKLMRLNMDGN------NLIQIPSQLPST-LEELKVNENNLQAIDEE 432
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+L++ L+ LE L +N + PL L +R+ K N I + S+
Sbjct: 433 SLSDLNQLVTLELEGNNLSEANVNPL-AFKPLKSLAYLRLGK---NKFRIIPQGLPGSIE 488
Query: 214 SLFVSNCELTSL-----NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
L++ N ++ + NH + + L + K+ N LA + ++L+ ID+SY
Sbjct: 489 ELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAW----INQENLESIDLSY 544
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFAN-NTELEYLDLSNNNIASLRYD--TFR 325
+ SL +L N + + F + LEYL LS N +A D +F
Sbjct: 545 NKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFY 604
Query: 326 G-LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
G L+ L L N++ IP + EM +L L+L+ N + +
Sbjct: 605 GAYHSLRELFLDHNDLKSIP-PGIQEMKALHFLRLNNNKIRNI 646
Score = 48.0 bits (109), Expect = 1e-04
Identities = 33/108 (30%), Positives = 56/108 (51%), Gaps = 2/108 (1%)
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI--AVIPEDSLLEMPSLTQLKLSRN 362
++ L+L+ N+IAS+ + F GL L+ LDLS N I + I + + L +L + N
Sbjct: 344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGN 403
Query: 363 YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLS 410
L ++ ++ L ++ L I ++SL L +V L+L N LS
Sbjct: 404 NLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 451
Score = 46.8 bits (106), Expect = 3e-04
Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 20/124 (16%)
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDS 392
L+L+ N IA IP+++ +P+L +L LS+N ++ G IG +
Sbjct: 348 LELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSG-------------------IGPKA 388
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
+ L+ ++ L++ N L IP + S TL+ L +N N + +I+ + LN+L +L + G
Sbjct: 389 FKLLKKLMRLNMDGNNLIQIPSQLPS-TLEELKVNENNLQAIDEESLSDLNQLVTLELEG 447
Query: 453 NRFT 456
N +
Sbjct: 448 NNLS 451
>BX537976-1|CAD97940.1| 693|Homo sapiens hypothetical protein
protein.
Length = 693
Score = 72.9 bits (171), Expect = 4e-12
Identities = 96/352 (27%), Positives = 151/352 (42%), Gaps = 30/352 (8%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL 97
C+L I C LT IP Q+T L ++ N P E+ + L NL LD+S N +
Sbjct: 348 CSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNI 407
Query: 98 --KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG-- 153
G+ A L L LN+ N NL LP+T L+ L ++ N Q +
Sbjct: 408 TSSGIGPKAFKLLKKLMRLNMDGN------NLIQIPSQLPST-LEELKVNENNLQAIDEE 460
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+L++ L+ LE L +N + PL L +R+ K N I + S+
Sbjct: 461 SLSDLNQLVTLELEGNNLSEANVNPL-AFKPLKSLAYLRLGK---NKFRIIPQGLPGSIE 516
Query: 214 SLFVSNCELTSL-----NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
L++ N ++ + NH + + L + K+ N LA + ++L+ ID+SY
Sbjct: 517 ELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAW----INQENLESIDLSY 572
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFAN-NTELEYLDLSNNNIASLRYD--TFR 325
+ SL +L N + + F + LEYL LS N +A D +F
Sbjct: 573 NKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFY 632
Query: 326 G-LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVT 376
G L+ L L N++ IP + EM +L L+L+ N + V +VT
Sbjct: 633 GAYHSLRELFLDHNDLKSIP-PGIQEMKALHFLRLNNNKIRCVSDAVLETVT 683
Score = 62.5 bits (145), Expect = 5e-09
Identities = 62/268 (23%), Positives = 123/268 (45%), Gaps = 16/268 (5%)
Query: 182 RSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKM 241
R P ++ R + L +I L + + SL ++ + S+ LP+L L +
Sbjct: 343 RLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDL 402
Query: 242 SNNYRLE--LASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA 299
S N + A L + ++ +++ N++Q + +L + +N N ++ ++ +
Sbjct: 403 SKNNITSSGIGPKAFKLLKKLMR-LNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEES 461
Query: 300 FANNTELEYLDLSNNNIASLRYD--TFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQ 356
++ +L L+L NN++ + F+ LK L +L L N+ +IP+ +P S+ +
Sbjct: 462 LSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQG----LPGSIEE 517
Query: 357 LKLSRNYLSRV-----GHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSY 411
L L N + + H R ++V +L + E N I + +++ +DLS N L +
Sbjct: 518 LYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYH 577
Query: 412 IPDSISSNTLKYLNLNYNRISSINNLTF 439
+P S +L +L L N+I I F
Sbjct: 578 VP-SYLPKSLLHLVLLGNQIERIPGYVF 604
Score = 46.8 bits (106), Expect = 3e-04
Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 20/124 (16%)
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDS 392
L+L+ N IA IP+++ +P+L +L LS+N ++ G IG +
Sbjct: 376 LELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSG-------------------IGPKA 416
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
+ L+ ++ L++ N L IP + S TL+ L +N N + +I+ + LN+L +L + G
Sbjct: 417 FKLLKKLMRLNMDGNNLIQIPSQLPS-TLEELKVNENNLQAIDEESLSDLNQLVTLELEG 475
Query: 453 NRFT 456
N +
Sbjct: 476 NNLS 479
>U80184-1|AAC02796.1| 1269|Homo sapiens FLII protein.
Length = 1269
Score = 72.5 bits (170), Expect = 5e-12
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 29/257 (11%)
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
+ + ++R LKLN L + +++ L L VS+ LT+L H EL LPSL +
Sbjct: 29 VKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTL-HGELSSLPSLRAIVAR 87
Query: 243 NNYRLELASSANNLFS-QSLKYIDISYCNILQ--PNLKGFPSLRKAILNHNMVRYLESNA 299
N L+ + +++F L +D+S+ + + L+ ++ L+HN + + +
Sbjct: 88 AN-SLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL 146
Query: 300 FANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKL 359
F N T+L YLDLS N + SL R L L+ L L+ N + L ++P++T L+
Sbjct: 147 FINLTDLLYLDLSENRLESLP-PQMRRLVHLQTLVLNGNPLL---HAQLRQLPAMTALQT 202
Query: 360 SRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI-SS 418
HLRS T ++ + SLEGL ++ ++DLS N L+ +P+ + +
Sbjct: 203 L--------HLRSTQRTQSNLPT---------SLEGLSNLADVDLSCNDLTRVPECLYTL 245
Query: 419 NTLKYLNLNYNRISSIN 435
+L+ LNL+ N+I+ ++
Sbjct: 246 PSLRRLNLSSNQITELS 262
Score = 60.9 bits (141), Expect = 2e-08
Identities = 73/274 (26%), Positives = 120/274 (43%), Gaps = 19/274 (6%)
Query: 78 PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT 137
P+ + +L +L LD+S NQL P L N + VLNLS N D+ PN + + T
Sbjct: 97 PDDIFKLDDLSVLDLSHNQLTECP-RELENAKNMLVLNLSHNSIDT----IPNQLFINLT 151
Query: 138 HLKILDLSFNKFQTMGNLANQELLIRPSLETLILD-----HCEINSIHGRSPLSGLINIR 192
L LDLS N+ +++ L+ L+TL+L+ H ++ + + L L
Sbjct: 152 DLLYLDLSENRLESLP--PQMRRLVH--LQTLVLNGNPLLHAQLRQLPAMTALQTLHLRS 207
Query: 193 VLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASS 252
+ N ++ L S+L + +S +LT + L LPSL L +S+N EL+
Sbjct: 208 TQRTQSNLPTSLEGL--SNLADVDLSCNDLTRVPEC-LYTLPSLRRLNLSSNQITELSLC 264
Query: 253 ANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLE-SNAFANNTELEYLDL 311
+ + + L + L+K LN N + + + T LE
Sbjct: 265 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMA 324
Query: 312 SNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPE 345
+NNN+ + R K L+ L L+ N + +PE
Sbjct: 325 ANNNLELVPESLCRCPK-LRKLVLNKNHLVTLPE 357
Score = 60.5 bits (140), Expect = 2e-08
Identities = 77/275 (28%), Positives = 130/275 (47%), Gaps = 37/275 (13%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLN 126
L++S+N+ T+ P L N++ L++S N + +P+ NLT L L+LS N +S
Sbjct: 109 LDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLES--- 165
Query: 127 LNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLS 186
L P + HL+ L L+ N + + ++L +L+TL L + + + L
Sbjct: 166 LPPQ--MRRLVHLQTLVLNGN---PLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 220
Query: 187 GLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELT---------------SLNHNE 229
GL N+ + L+ N L R+ + + SLR L +S+ ++T +L+ N+
Sbjct: 221 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280
Query: 230 LMFLPS----LTHLK--MSNNYRLE---LASSANNLFSQSLKYIDISYCNILQPNLKGFP 280
L LPS L+ LK N+ +L+ L S L + + ++ +L P
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340
Query: 281 SLRKAILNHN-MVRYLESNAFANNTELEYLDLSNN 314
LRK +LN N +V E+ F TE+E LD+ N
Sbjct: 341 KLRKLVLNKNHLVTLPEAIHFL--TEIEVLDVREN 373
Score = 48.8 bits (111), Expect = 7e-05
Identities = 43/151 (28%), Positives = 73/151 (48%), Gaps = 6/151 (3%)
Query: 309 LDLSNNNIASLRY-DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
+DLS N+ + + + + L+ L L+ + +PE+ L + L L +S N L+ +
Sbjct: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEE-LAALQKLEHLSVSHNNLTTL 71
Query: 368 -GHLRSM-SVTILDMSSCELNTIG-KDSLEGLQSIVELDLSQNLLSYIPDSI-SSNTLKY 423
G L S+ S+ + + L G D + L + LDLS N L+ P + ++ +
Sbjct: 72 HGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLV 131
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNR 454
LNL++N I +I N F L L L + NR
Sbjct: 132 LNLSHNSIDTIPNQLFINLTDLLYLDLSENR 162
Score = 41.5 bits (93), Expect = 0.011
Identities = 26/80 (32%), Positives = 45/80 (56%), Gaps = 3/80 (3%)
Query: 45 DIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPD 102
D+D S LT +P L + +LN+S+N+ T+ + + ++ L++S NQL LP
Sbjct: 227 DVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLP- 285
Query: 103 NALYNLTALEVLNLSRNYFD 122
+A+ L+ L+ L L+ N D
Sbjct: 286 SAICKLSKLKKLYLNSNKLD 305
Score = 35.1 bits (77), Expect = 0.92
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 3/60 (5%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQL--KGLPDNALYNLTALEVLNLSRN 119
+ V LN+S N+ T P ++ +L L L ++SN+L GLP + + LT LE + N
Sbjct: 269 VHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLP-SGIGKLTNLEEFMAANN 327
>U01184-1|AAC03568.1| 1268|Homo sapiens flightless-I homolog
protein.
Length = 1268
Score = 72.5 bits (170), Expect = 5e-12
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 29/257 (11%)
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
+ + ++R LKLN L + +++ L L VS+ LT+L H EL LPSL +
Sbjct: 28 VKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTL-HGELSSLPSLRAIVAR 86
Query: 243 NNYRLELASSANNLFS-QSLKYIDISYCNILQ--PNLKGFPSLRKAILNHNMVRYLESNA 299
N L+ + +++F L +D+S+ + + L+ ++ L+HN + + +
Sbjct: 87 AN-SLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL 145
Query: 300 FANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKL 359
F N T+L YLDLS N + SL R L L+ L L+ N + L ++P++T L+
Sbjct: 146 FINLTDLLYLDLSENRLESLP-PQMRRLVHLQTLVLNGNPLL---HAQLRQLPAMTALQT 201
Query: 360 SRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI-SS 418
HLRS T ++ + SLEGL ++ ++DLS N L+ +P+ + +
Sbjct: 202 L--------HLRSTQRTQSNLPT---------SLEGLSNLADVDLSCNDLTRVPECLYTL 244
Query: 419 NTLKYLNLNYNRISSIN 435
+L+ LNL+ N+I+ ++
Sbjct: 245 PSLRRLNLSSNQITELS 261
Score = 60.9 bits (141), Expect = 2e-08
Identities = 73/274 (26%), Positives = 120/274 (43%), Gaps = 19/274 (6%)
Query: 78 PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT 137
P+ + +L +L LD+S NQL P L N + VLNLS N D+ PN + + T
Sbjct: 96 PDDIFKLDDLSVLDLSHNQLTECP-RELENAKNMLVLNLSHNSIDT----IPNQLFINLT 150
Query: 138 HLKILDLSFNKFQTMGNLANQELLIRPSLETLILD-----HCEINSIHGRSPLSGLINIR 192
L LDLS N+ +++ L+ L+TL+L+ H ++ + + L L
Sbjct: 151 DLLYLDLSENRLESLP--PQMRRLVH--LQTLVLNGNPLLHAQLRQLPAMTALQTLHLRS 206
Query: 193 VLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASS 252
+ N ++ L S+L + +S +LT + L LPSL L +S+N EL+
Sbjct: 207 TQRTQSNLPTSLEGL--SNLADVDLSCNDLTRVPEC-LYTLPSLRRLNLSSNQITELSLC 263
Query: 253 ANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLE-SNAFANNTELEYLDL 311
+ + + L + L+K LN N + + + T LE
Sbjct: 264 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMA 323
Query: 312 SNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPE 345
+NNN+ + R K L+ L L+ N + +PE
Sbjct: 324 ANNNLELVPESLCRCPK-LRKLVLNKNHLVTLPE 356
Score = 60.5 bits (140), Expect = 2e-08
Identities = 77/275 (28%), Positives = 130/275 (47%), Gaps = 37/275 (13%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLN 126
L++S+N+ T+ P L N++ L++S N + +P+ NLT L L+LS N +S
Sbjct: 108 LDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLES--- 164
Query: 127 LNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLS 186
L P + HL+ L L+ N + + ++L +L+TL L + + + L
Sbjct: 165 LPPQ--MRRLVHLQTLVLNGN---PLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 219
Query: 187 GLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELT---------------SLNHNE 229
GL N+ + L+ N L R+ + + SLR L +S+ ++T +L+ N+
Sbjct: 220 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 279
Query: 230 LMFLPS----LTHLK--MSNNYRLE---LASSANNLFSQSLKYIDISYCNILQPNLKGFP 280
L LPS L+ LK N+ +L+ L S L + + ++ +L P
Sbjct: 280 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 339
Query: 281 SLRKAILNHN-MVRYLESNAFANNTELEYLDLSNN 314
LRK +LN N +V E+ F TE+E LD+ N
Sbjct: 340 KLRKLVLNKNHLVTLPEAIHFL--TEIEVLDVREN 372
Score = 48.8 bits (111), Expect = 7e-05
Identities = 43/151 (28%), Positives = 73/151 (48%), Gaps = 6/151 (3%)
Query: 309 LDLSNNNIASLRY-DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
+DLS N+ + + + + L+ L L+ + +PE+ L + L L +S N L+ +
Sbjct: 12 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEE-LAALQKLEHLSVSHNNLTTL 70
Query: 368 -GHLRSM-SVTILDMSSCELNTIG-KDSLEGLQSIVELDLSQNLLSYIPDSI-SSNTLKY 423
G L S+ S+ + + L G D + L + LDLS N L+ P + ++ +
Sbjct: 71 HGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLV 130
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNR 454
LNL++N I +I N F L L L + NR
Sbjct: 131 LNLSHNSIDTIPNQLFINLTDLLYLDLSENR 161
Score = 41.5 bits (93), Expect = 0.011
Identities = 26/80 (32%), Positives = 45/80 (56%), Gaps = 3/80 (3%)
Query: 45 DIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPD 102
D+D S LT +P L + +LN+S+N+ T+ + + ++ L++S NQL LP
Sbjct: 226 DVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLP- 284
Query: 103 NALYNLTALEVLNLSRNYFD 122
+A+ L+ L+ L L+ N D
Sbjct: 285 SAICKLSKLKKLYLNSNKLD 304
Score = 35.1 bits (77), Expect = 0.92
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 3/60 (5%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQL--KGLPDNALYNLTALEVLNLSRN 119
+ V LN+S N+ T P ++ +L L L ++SN+L GLP + + LT LE + N
Sbjct: 268 VHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLP-SGIGKLTNLEEFMAANN 326
>BC109118-1|AAI09119.1| 858|Homo sapiens TLR5 protein protein.
Length = 858
Score = 72.5 bits (170), Expect = 5e-12
Identities = 112/437 (25%), Positives = 202/437 (46%), Gaps = 47/437 (10%)
Query: 64 VTKLNISNNEFTKF--PESLSRLHNLVNLDISSNQLKGLPDNALYNLTA--LEVLNLSRN 119
+T+L++S N+ S +L++L ++D SSNQ+ + ++ L L L +L+ N
Sbjct: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAAN 206
Query: 120 YFDSWLNLNPNDVLLPATH--LKILDLSFNKFQT--MGNLANQELLIRPSLETLILDHCE 175
S ++++ + P + L+ILD+S N + GN +N + + +LIL H
Sbjct: 207 SLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNA--ISKSQAFSLILAH-- 262
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
H G NI+ N L SS+R L +S+ + SLN L
Sbjct: 263 ----HIMGAGFGFHNIKDPDQN-----TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKD 313
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL----QPNLKGFPSLRKAILNHNM 291
L L ++ N ++A A +L+ +++SY N+L N G P + L N
Sbjct: 314 LKVLNLAYNKINKIADEAFYGLD-NLQVLNLSY-NLLGELYSSNFYGLPKVAYIDLQKNH 371
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL-E 350
+ ++ F +L+ LDL +N + ++ + + + + LS N++ +P+ +L
Sbjct: 372 IAIIQDQTFKFLEKLQTLDLRDNALTTIHF-----IPSIPDIFLSGNKLVTLPKINLTAN 426
Query: 351 MPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKD--SLEGL---QSIVE 401
+ L++ +L +L RV HL+ + + SSC + + SLE L +++++
Sbjct: 427 LIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQ 486
Query: 402 LDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L L + + +S L+ L LN+N ++S+ F L L LS+ NR T++
Sbjct: 487 LAWETELCWDVFEGLSH--LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL--- 541
Query: 462 SFFDSNPYLERLDLSDN 478
S D LE LD+S N
Sbjct: 542 SHNDLPANLEILDISRN 558
Score = 66.9 bits (156), Expect = 2e-10
Identities = 54/216 (25%), Positives = 105/216 (48%), Gaps = 7/216 (3%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
S+R L+H V L S F +L+ L+L+ N I + + F GL L+ L+LS+N +
Sbjct: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD-MSSCELNTIGKDSLEGLQSI 399
+ + +P + + L +N+++ + + + L+ + + +L ++ + SI
Sbjct: 349 GELYSSNFYGLPKVAYIDLQKNHIAII---QDQTFKFLEKLQTLDLRDNALTTIHFIPSI 405
Query: 400 VELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFM-LNRLTSLSVVGNRFTMI 458
++ LS N L +P + T ++L+ NR+ +++ L F + + L L + NRF+
Sbjct: 406 PDIFLSGNKLVTLPKI--NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSC 463
Query: 459 WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
NP LE+L L +NM + E D ++
Sbjct: 464 SGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499
Score = 46.4 bits (105), Expect = 4e-04
Identities = 69/267 (25%), Positives = 115/267 (43%), Gaps = 23/267 (8%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLN----PN--DVLLPAT 137
L +L L+++ N++ + D A Y L L+VLNLS N + N P + L
Sbjct: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370
Query: 138 HLKIL-DLSF---NKFQTMGNLANQELLIR--PSLETLILDHCEINSIHGRSPLSGLINI 191
H+ I+ D +F K QT+ N I PS+ + L ++ ++ + + LI++
Sbjct: 371 HIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHL 430
Query: 192 RVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNEL-MFLPSLTHLKMSNN-----Y 245
+L +L L L+ L ++ +S + ++ PSL L + N +
Sbjct: 431 SENRLENLDILYFL-LRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAW 489
Query: 246 RLELASSA-NNLFSQSLKYIDISYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANN 303
EL L + Y++ +Y N L P + +LR LN N + L N N
Sbjct: 490 ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPAN 549
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKML 330
LE LD+S N + + D F L +L
Sbjct: 550 --LEILDISRNQLLAPNPDVFVSLSVL 574
Score = 40.3 bits (90), Expect = 0.024
Identities = 66/254 (25%), Positives = 109/254 (42%), Gaps = 20/254 (7%)
Query: 67 LNISNNEFTK-FPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
LN+S N + + + L + +D+ N + + D L L+ L+L N + +
Sbjct: 341 LNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTT-I 399
Query: 126 NLNPN--DVLLPATHLKIL---DLSFNKFQTMGN-LANQELL---IR-PSLETLILDHCE 175
+ P+ D+ L L L +L+ N N L N ++L +R P L+ LIL+
Sbjct: 400 HFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNR 459
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPL-LRIQNLISSSLRSLFVSNCELTSLNHNELMFLP 234
+S G S ++ L L N L L + + + +S+ ++ LNHN L LP
Sbjct: 460 FSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE-GLSHLQVLYLNHNYLNSLP 518
Query: 235 S--LTHLKMSNNYRLE---LASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNH 289
+HL L L ++N +L+ +DIS +L PN F SL + H
Sbjct: 519 PGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITH 578
Query: 290 N-MVRYLESNAFAN 302
N + E + F N
Sbjct: 579 NKFICECELSTFIN 592
Score = 39.5 bits (88), Expect = 0.043
Identities = 55/225 (24%), Positives = 108/225 (48%), Gaps = 27/225 (12%)
Query: 268 YCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL-SNNNIASLRYDTFR 325
+CN+ Q P + + + +L+ N +R + +++F +L+ L+L S ++ + FR
Sbjct: 35 FCNLTQVPQVLN--TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFR 92
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS----RVGHLRSM-SVTILDM 380
L L+ LDL ++I + D+ + L +L+L LS + G+ R++ ++T LD+
Sbjct: 93 NLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDL 152
Query: 381 SSCELNTIG-KDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTF 439
S ++ ++ S L S+ +D S N + + + + L+ L L+F
Sbjct: 153 SKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCE----HELEPLQGK--------TLSF 200
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFD-SNPYLERLDLSDNMWRCD 483
F L + + + +R ++ W + N LE LD+S N W D
Sbjct: 201 FSL----AANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVD 241
>BC032667-1|AAH32667.1| 352|Homo sapiens keratocan protein.
Length = 352
Score = 72.5 bits (170), Expect = 5e-12
Identities = 72/262 (27%), Positives = 134/262 (51%), Gaps = 25/262 (9%)
Query: 268 YCNILQPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIAS--LRY 321
YC LK P++ I L +N++ + F N T+L +++L+ N I + +
Sbjct: 57 YCE--NRGLKEIPAIPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEK 114
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRNYLSRV--GHLRSM-SVTI 377
LK L L L NE+ +P +P SL QL+L+RN +SR+ G ++ ++T+
Sbjct: 115 GALSQLKKLLFLFLEDNELEEVPSP----LPRSLEQLQLARNKVSRIPQGTFSNLENLTL 170
Query: 378 LDMSSCEL--NTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSIN 435
LD+ + +L N +D+ +GL+++++L++++N L +P + +NT++ L L+ N I I
Sbjct: 171 LDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQ-LFLDNNSIEGIP 229
Query: 436 NLTFFMLNRLTSLSVVGNRFTMIWRRS-FFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F ++ ++ L + N+ + S FD + L+ L LS N +
Sbjct: 230 ENYFNVIPKVAFLRLNHNKLSDEGLPSRGFDVSSILD-LQLSHNQL---TKVPRISAHLQ 285
Query: 495 FVTLEPNK-KEESFNLICNSPA 515
+ L+ NK K + ++IC SP+
Sbjct: 286 HLHLDHNKIKSVNVSVICPSPS 307
>BC025300-1|AAH25300.1| 1269|Homo sapiens flightless I homolog
(Drosophila) protein.
Length = 1269
Score = 72.5 bits (170), Expect = 5e-12
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 29/257 (11%)
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
+ + ++R LKLN L + +++ L L VS+ LT+L H EL LPSL +
Sbjct: 29 VKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTL-HGELSSLPSLRAIVAR 87
Query: 243 NNYRLELASSANNLFS-QSLKYIDISYCNILQ--PNLKGFPSLRKAILNHNMVRYLESNA 299
N L+ + +++F L +D+S+ + + L+ ++ L+HN + + +
Sbjct: 88 AN-SLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL 146
Query: 300 FANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKL 359
F N T+L YLDLS N + SL R L L+ L L+ N + L ++P++T L+
Sbjct: 147 FINLTDLLYLDLSENRLESLP-PQMRRLVHLQTLVLNGNPLL---HAQLRQLPAMTALQT 202
Query: 360 SRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI-SS 418
HLRS T ++ + SLEGL ++ ++DLS N L+ +P+ + +
Sbjct: 203 L--------HLRSTQRTQSNLPT---------SLEGLSNLADVDLSCNDLTRVPECLYTL 245
Query: 419 NTLKYLNLNYNRISSIN 435
+L+ LNL+ N+I+ ++
Sbjct: 246 PSLRRLNLSSNQITELS 262
Score = 60.9 bits (141), Expect = 2e-08
Identities = 73/274 (26%), Positives = 120/274 (43%), Gaps = 19/274 (6%)
Query: 78 PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT 137
P+ + +L +L LD+S NQL P L N + VLNLS N D+ PN + + T
Sbjct: 97 PDDIFKLDDLSVLDLSHNQLTECP-RELENAKNMLVLNLSHNSIDT----IPNQLFINLT 151
Query: 138 HLKILDLSFNKFQTMGNLANQELLIRPSLETLILD-----HCEINSIHGRSPLSGLINIR 192
L LDLS N+ +++ L+ L+TL+L+ H ++ + + L L
Sbjct: 152 DLLYLDLSENRLESLP--PQMRRLVH--LQTLVLNGNPLLHAQLRQLPAMTALQTLHLRS 207
Query: 193 VLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASS 252
+ N ++ L S+L + +S +LT + L LPSL L +S+N EL+
Sbjct: 208 TQRTQSNLPTSLEGL--SNLADVDLSCNDLTRVPEC-LYTLPSLRRLNLSSNQITELSLC 264
Query: 253 ANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLE-SNAFANNTELEYLDL 311
+ + + L + L+K LN N + + + T LE
Sbjct: 265 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMA 324
Query: 312 SNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPE 345
+NNN+ + R K L+ L L+ N + +PE
Sbjct: 325 ANNNLELVPESLCRCPK-LRKLVLNKNHLVTLPE 357
Score = 60.5 bits (140), Expect = 2e-08
Identities = 77/275 (28%), Positives = 130/275 (47%), Gaps = 37/275 (13%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLN 126
L++S+N+ T+ P L N++ L++S N + +P+ NLT L L+LS N +S
Sbjct: 109 LDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLES--- 165
Query: 127 LNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLS 186
L P + HL+ L L+ N + + ++L +L+TL L + + + L
Sbjct: 166 LPPQ--MRRLVHLQTLVLNGN---PLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 220
Query: 187 GLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELT---------------SLNHNE 229
GL N+ + L+ N L R+ + + SLR L +S+ ++T +L+ N+
Sbjct: 221 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280
Query: 230 LMFLPS----LTHLK--MSNNYRLE---LASSANNLFSQSLKYIDISYCNILQPNLKGFP 280
L LPS L+ LK N+ +L+ L S L + + ++ +L P
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340
Query: 281 SLRKAILNHN-MVRYLESNAFANNTELEYLDLSNN 314
LRK +LN N +V E+ F TE+E LD+ N
Sbjct: 341 KLRKLVLNKNHLVTLPEAIHFL--TEIEVLDVREN 373
Score = 48.8 bits (111), Expect = 7e-05
Identities = 43/151 (28%), Positives = 73/151 (48%), Gaps = 6/151 (3%)
Query: 309 LDLSNNNIASLRY-DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
+DLS N+ + + + + L+ L L+ + +PE+ L + L L +S N L+ +
Sbjct: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEE-LAALQKLEHLSVSHNNLTTL 71
Query: 368 -GHLRSM-SVTILDMSSCELNTIG-KDSLEGLQSIVELDLSQNLLSYIPDSI-SSNTLKY 423
G L S+ S+ + + L G D + L + LDLS N L+ P + ++ +
Sbjct: 72 HGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLV 131
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNR 454
LNL++N I +I N F L L L + NR
Sbjct: 132 LNLSHNSIDTIPNQLFINLTDLLYLDLSENR 162
Score = 41.5 bits (93), Expect = 0.011
Identities = 26/80 (32%), Positives = 45/80 (56%), Gaps = 3/80 (3%)
Query: 45 DIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPD 102
D+D S LT +P L + +LN+S+N+ T+ + + ++ L++S NQL LP
Sbjct: 227 DVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLP- 285
Query: 103 NALYNLTALEVLNLSRNYFD 122
+A+ L+ L+ L L+ N D
Sbjct: 286 SAICKLSKLKKLYLNSNKLD 305
Score = 35.1 bits (77), Expect = 0.92
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 3/60 (5%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQL--KGLPDNALYNLTALEVLNLSRN 119
+ V LN+S N+ T P ++ +L L L ++SN+L GLP + + LT LE + N
Sbjct: 269 VHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLP-SGIGKLTNLEEFMAANN 327
>AY250221-1|AAP82838.1| 420|Homo sapiens nogo receptor-like 3
protein.
Length = 420
Score = 72.5 bits (170), Expect = 5e-12
Identities = 63/211 (29%), Positives = 103/211 (48%), Gaps = 9/211 (4%)
Query: 280 PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE 339
PS ++ L +N++R L + F +N L L L +NN++++ TFR L+ L+ LDL N
Sbjct: 60 PSTQRLFLQNNLIRTLRPSTFGSN--LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNR 117
Query: 340 -IAVIPEDSLLEMPSLTQLKLSRNYLSRV-GHL-RSM-SVTILDMSSCELNTIGKDSLEG 395
+ + D+ + L L L R LS + G++ R + S+ L + L + D
Sbjct: 118 HLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFAD 177
Query: 396 LQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
L ++ L L N L + + + +L L L+ NR+ ++ F L+RLT L + N
Sbjct: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237
Query: 454 RFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
+ + D P LE L L+ N W CDC
Sbjct: 238 SLASLPGEALADL-PSLEFLRLNANPWACDC 267
Score = 58.4 bits (135), Expect = 9e-08
Identities = 58/215 (26%), Positives = 99/215 (46%), Gaps = 9/215 (4%)
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
N ++ L + PS + L L + I ++ + S L+ + + N + + +L
Sbjct: 50 NFSSVPLSLPPSTQRLFLQNNLIRTLRPSTFGSNLLTLWLFSNNLSTIYPGTFRHLQALE 109
Query: 214 SLFVS-NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ--SLKYIDISYCN 270
L + N L SL + L L L + YR +L+S N+F SL+Y+ + +
Sbjct: 110 ELDLGDNRHLRSLEPDTFQGLERLQSLHL---YRCQLSSLPGNIFRGLVSLQYLYLQENS 166
Query: 271 IL--QPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL 327
+L Q +L +L L+ N +R L + F L+ L L N + + FRGL
Sbjct: 167 LLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGL 226
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
L L L N +A +P ++L ++PSL L+L+ N
Sbjct: 227 SRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Score = 50.4 bits (115), Expect = 2e-05
Identities = 51/179 (28%), Positives = 82/179 (45%), Gaps = 9/179 (5%)
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPN-LKGFPSLRKAILNHNM 291
LT SNN + +L Q+L+ +D+ + L+P+ +G L+ L
Sbjct: 85 LTLWLFSNNLSTIYPGTFRHL--QALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQ 142
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ L N F L+YL L N++ L+ D F L L HL L N + ++ E +
Sbjct: 143 LSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGL 202
Query: 352 PSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
SL +L L N L V R +S +TIL + + L ++ ++L L S+ L L+ N
Sbjct: 203 GSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Score = 37.9 bits (84), Expect = 0.13
Identities = 66/262 (25%), Positives = 107/262 (40%), Gaps = 41/262 (15%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISS 94
LC C + C + +P L +L + NN T P + NL+ L + S
Sbjct: 34 LCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPSTFG--SNLLTLWLFS 91
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N L + +L ALE L+L N HL+ L+ + FQ +
Sbjct: 92 NNLSTIYPGTFRHLQALEELDLGDN-----------------RHLRSLEP--DTFQGLER 132
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
L ++L L C+++S+ G + GL++++ L L N LL +Q+ + + L +
Sbjct: 133 L-----------QSLHLYRCQLSSLPG-NIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
Query: 215 ---LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA--NNLFSQSLKYI-DISY 268
LF+ L L + L SL L + N RL+ A L ++ Y+ + S
Sbjct: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGN-RLQGVHRAAFRGLSRLTILYLFNNSL 239
Query: 269 CNILQPNLKGFPSLRKAILNHN 290
++ L PSL LN N
Sbjct: 240 ASLPGEALADLPSLEFLRLNAN 261
Score = 33.1 bits (72), Expect = 3.7
Identities = 35/118 (29%), Positives = 47/118 (39%), Gaps = 4/118 (3%)
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFM 441
SC+ N L S L L NL+ + S + L L L N +S+I TF
Sbjct: 45 SCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPSTFGSNLLTLWLFSNNLSTIYPGTFRH 104
Query: 442 LNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLE 499
L L L + NR F LERL S +++RC S F V+L+
Sbjct: 105 LQALEELDLGDNRHLRSLEPDTFQG---LERLQ-SLHLYRCQLSSLPGNIFRGLVSLQ 158
>AL929091-1|CAM28378.1| 858|Homo sapiens toll-like receptor 5
protein.
Length = 858
Score = 72.5 bits (170), Expect = 5e-12
Identities = 112/437 (25%), Positives = 202/437 (46%), Gaps = 47/437 (10%)
Query: 64 VTKLNISNNEFTKF--PESLSRLHNLVNLDISSNQLKGLPDNALYNLTA--LEVLNLSRN 119
+T+L++S N+ S +L++L ++D SSNQ+ + ++ L L L +L+ N
Sbjct: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAAN 206
Query: 120 YFDSWLNLNPNDVLLPATH--LKILDLSFNKFQT--MGNLANQELLIRPSLETLILDHCE 175
S ++++ + P + L+ILD+S N + GN +N + + +LIL H
Sbjct: 207 SLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNA--ISKSQAFSLILAH-- 262
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
H G NI+ N L SS+R L +S+ + SLN L
Sbjct: 263 ----HIMGAGFGFHNIKDPDQN-----TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKD 313
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL----QPNLKGFPSLRKAILNHNM 291
L L ++ N ++A A +L+ +++SY N+L N G P + L N
Sbjct: 314 LKVLNLAYNKINKIADEAFYGLD-NLQVLNLSY-NLLGELYSSNFYGLPKVAYIDLQKNH 371
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL-E 350
+ ++ F +L+ LDL +N + ++ + + + + LS N++ +P+ +L
Sbjct: 372 IAIIQDQTFKFLEKLQTLDLRDNALTTIHF-----IPSIPDIFLSGNKLVTLPKINLTAN 426
Query: 351 MPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKD--SLEGL---QSIVE 401
+ L++ +L +L RV HL+ + + SSC + + SLE L +++++
Sbjct: 427 LIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQ 486
Query: 402 LDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L L + + +S L+ L LN+N ++S+ F L L LS+ NR T++
Sbjct: 487 LAWETELCWDVFEGLSH--LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL--- 541
Query: 462 SFFDSNPYLERLDLSDN 478
S D LE LD+S N
Sbjct: 542 SHNDLPANLEILDISRN 558
Score = 66.9 bits (156), Expect = 2e-10
Identities = 54/216 (25%), Positives = 105/216 (48%), Gaps = 7/216 (3%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
S+R L+H V L S F +L+ L+L+ N I + + F GL L+ L+LS+N +
Sbjct: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD-MSSCELNTIGKDSLEGLQSI 399
+ + +P + + L +N+++ + + + L+ + + +L ++ + SI
Sbjct: 349 GELYSSNFYGLPKVAYIDLQKNHIAII---QDQTFKFLEKLQTLDLRDNALTTIHFIPSI 405
Query: 400 VELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFM-LNRLTSLSVVGNRFTMI 458
++ LS N L +P + T ++L+ NR+ +++ L F + + L L + NRF+
Sbjct: 406 PDIFLSGNKLVTLPKI--NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSC 463
Query: 459 WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
NP LE+L L +NM + E D ++
Sbjct: 464 SGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499
Score = 46.4 bits (105), Expect = 4e-04
Identities = 69/267 (25%), Positives = 115/267 (43%), Gaps = 23/267 (8%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLN----PN--DVLLPAT 137
L +L L+++ N++ + D A Y L L+VLNLS N + N P + L
Sbjct: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370
Query: 138 HLKIL-DLSF---NKFQTMGNLANQELLIR--PSLETLILDHCEINSIHGRSPLSGLINI 191
H+ I+ D +F K QT+ N I PS+ + L ++ ++ + + LI++
Sbjct: 371 HIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHL 430
Query: 192 RVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNEL-MFLPSLTHLKMSNN-----Y 245
+L +L L L+ L ++ +S + ++ PSL L + N +
Sbjct: 431 SENRLENLDILYFL-LRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAW 489
Query: 246 RLELASSA-NNLFSQSLKYIDISYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANN 303
EL L + Y++ +Y N L P + +LR LN N + L N N
Sbjct: 490 ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPAN 549
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKML 330
LE LD+S N + + D F L +L
Sbjct: 550 --LEILDISRNQLLAPNPDVFVSLSVL 574
Score = 40.3 bits (90), Expect = 0.024
Identities = 66/254 (25%), Positives = 109/254 (42%), Gaps = 20/254 (7%)
Query: 67 LNISNNEFTK-FPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
LN+S N + + + L + +D+ N + + D L L+ L+L N + +
Sbjct: 341 LNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTT-I 399
Query: 126 NLNPN--DVLLPATHLKIL---DLSFNKFQTMGN-LANQELL---IR-PSLETLILDHCE 175
+ P+ D+ L L L +L+ N N L N ++L +R P L+ LIL+
Sbjct: 400 HFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNR 459
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPL-LRIQNLISSSLRSLFVSNCELTSLNHNELMFLP 234
+S G S ++ L L N L L + + + +S+ ++ LNHN L LP
Sbjct: 460 FSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE-GLSHLQVLYLNHNYLNSLP 518
Query: 235 S--LTHLKMSNNYRLE---LASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNH 289
+HL L L ++N +L+ +DIS +L PN F SL + H
Sbjct: 519 PGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITH 578
Query: 290 N-MVRYLESNAFAN 302
N + E + F N
Sbjct: 579 NKFICECELSTFIN 592
Score = 39.5 bits (88), Expect = 0.043
Identities = 55/225 (24%), Positives = 108/225 (48%), Gaps = 27/225 (12%)
Query: 268 YCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL-SNNNIASLRYDTFR 325
+CN+ Q P + + + +L+ N +R + +++F +L+ L+L S ++ + FR
Sbjct: 35 FCNLTQVPQVLN--TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFR 92
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS----RVGHLRSM-SVTILDM 380
L L+ LDL ++I + D+ + L +L+L LS + G+ R++ ++T LD+
Sbjct: 93 NLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDL 152
Query: 381 SSCELNTIG-KDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTF 439
S ++ ++ S L S+ +D S N + + + + L+ L L+F
Sbjct: 153 SKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCE----HELEPLQGK--------TLSF 200
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFD-SNPYLERLDLSDNMWRCD 483
F L + + + +R ++ W + N LE LD+S N W D
Sbjct: 201 FSL----AANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVD 241
>AF205403-1|AAF69126.1| 352|Homo sapiens keratocan protein.
Length = 352
Score = 72.5 bits (170), Expect = 5e-12
Identities = 72/262 (27%), Positives = 134/262 (51%), Gaps = 25/262 (9%)
Query: 268 YCNILQPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIAS--LRY 321
YC LK P++ I L +N++ + F N T+L +++L+ N I + +
Sbjct: 57 YCE--NRGLKEIPAIPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEK 114
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRNYLSRV--GHLRSM-SVTI 377
LK L L L NE+ +P +P SL QL+L+RN +SR+ G ++ ++T+
Sbjct: 115 GALSQLKKLLFLFLEDNELEEVPSP----LPRSLEQLQLARNKVSRIPQGTFSNLENLTL 170
Query: 378 LDMSSCEL--NTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSIN 435
LD+ + +L N +D+ +GL+++++L++++N L +P + +NT++ L L+ N I I
Sbjct: 171 LDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQ-LFLDNNSIEGIP 229
Query: 436 NLTFFMLNRLTSLSVVGNRFTMIWRRS-FFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F ++ ++ L + N+ + S FD + L+ L LS N +
Sbjct: 230 ENYFNVIPKVAFLRLNHNKLSDEGLPSRGFDVSSILD-LQLSHNQL---TKVPRISAHLQ 285
Query: 495 FVTLEPNK-KEESFNLICNSPA 515
+ L+ NK K + ++IC SP+
Sbjct: 286 HLHLDHNKIKSVNVSVICPSPS 307
>AF065988-1|AAC17741.1| 352|Homo sapiens keratocan protein.
Length = 352
Score = 72.5 bits (170), Expect = 5e-12
Identities = 72/262 (27%), Positives = 134/262 (51%), Gaps = 25/262 (9%)
Query: 268 YCNILQPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIAS--LRY 321
YC LK P++ I L +N++ + F N T+L +++L+ N I + +
Sbjct: 57 YCE--NRGLKEIPAIPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEK 114
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRNYLSRV--GHLRSM-SVTI 377
LK L L L NE+ +P +P SL QL+L+RN +SR+ G ++ ++T+
Sbjct: 115 GALSQLKKLLFLFLEDNELEEVPSP----LPRSLEQLQLARNKVSRIPQGTFSNLENLTL 170
Query: 378 LDMSSCEL--NTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSIN 435
LD+ + +L N +D+ +GL+++++L++++N L +P + +NT++ L L+ N I I
Sbjct: 171 LDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQ-LFLDNNSIEGIP 229
Query: 436 NLTFFMLNRLTSLSVVGNRFTMIWRRS-FFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F ++ ++ L + N+ + S FD + L+ L LS N +
Sbjct: 230 ENYFNVIPKVAFLRLNHNKLSDEGLPSRGFDVSSILD-LQLSHNQL---TKVPRISAHLQ 285
Query: 495 FVTLEPNK-KEESFNLICNSPA 515
+ L+ NK K + ++IC SP+
Sbjct: 286 HLHLDHNKIKSVNVSVICPSPS 307
>AF063301-1|AAC16390.1| 352|Homo sapiens keratan sulfate
proteoglycan protein.
Length = 352
Score = 72.5 bits (170), Expect = 5e-12
Identities = 72/262 (27%), Positives = 134/262 (51%), Gaps = 25/262 (9%)
Query: 268 YCNILQPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIAS--LRY 321
YC LK P++ I L +N++ + F N T+L +++L+ N I + +
Sbjct: 57 YCE--NRGLKEIPAIPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEK 114
Query: 322 DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRNYLSRV--GHLRSM-SVTI 377
LK L L L NE+ +P +P SL QL+L+RN +SR+ G ++ ++T+
Sbjct: 115 GALSQLKKLLFLFLEDNELEEVPSP----LPRSLEQLQLARNKVSRIPQGTFSNLENLTL 170
Query: 378 LDMSSCEL--NTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSIN 435
LD+ + +L N +D+ +GL+++++L++++N L +P + +NT++ L L+ N I I
Sbjct: 171 LDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQ-LFLDNNSIEGIP 229
Query: 436 NLTFFMLNRLTSLSVVGNRFTMIWRRS-FFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
F ++ ++ L + N+ + S FD + L+ L LS N +
Sbjct: 230 ENYFNVIPKVAFLRLNHNKLSDEGLPSRGFDVSSILD-LQLSHNQL---TKVPRISAHLQ 285
Query: 495 FVTLEPNK-KEESFNLICNSPA 515
+ L+ NK K + ++IC SP+
Sbjct: 286 HLHLDHNKIKSVNVSVICPSPS 307
>AB208864-1|BAD92101.1| 1101|Homo sapiens flightless I homolog
variant protein.
Length = 1101
Score = 72.5 bits (170), Expect = 5e-12
Identities = 74/257 (28%), Positives = 131/257 (50%), Gaps = 29/257 (11%)
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
+ + ++R LKLN L + +++ L L VS+ LT+L H EL LPSL +
Sbjct: 16 VKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTL-HGELSSLPSLRAIVAR 74
Query: 243 NNYRLELASSANNLFS-QSLKYIDISYCNILQ--PNLKGFPSLRKAILNHNMVRYLESNA 299
N L+ + +++F L +D+S+ + + L+ ++ L+HN + + +
Sbjct: 75 AN-SLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL 133
Query: 300 FANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKL 359
F N T+L YLDLS N + SL R L L+ L L+ N + L ++P++T L+
Sbjct: 134 FINLTDLLYLDLSENRLESLP-PQMRRLVHLQTLVLNGNPLL---HAQLRQLPAMTALQT 189
Query: 360 SRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI-SS 418
HLRS T ++ + SLEGL ++ ++DLS N L+ +P+ + +
Sbjct: 190 L--------HLRSTQRTQSNLPT---------SLEGLSNLADVDLSCNDLTRVPECLYTL 232
Query: 419 NTLKYLNLNYNRISSIN 435
+L+ LNL+ N+I+ ++
Sbjct: 233 PSLRRLNLSSNQITELS 249
Score = 60.9 bits (141), Expect = 2e-08
Identities = 73/274 (26%), Positives = 120/274 (43%), Gaps = 19/274 (6%)
Query: 78 PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT 137
P+ + +L +L LD+S NQL P L N + VLNLS N D+ PN + + T
Sbjct: 84 PDDIFKLDDLSVLDLSHNQLTECP-RELENAKNMLVLNLSHNSIDT----IPNQLFINLT 138
Query: 138 HLKILDLSFNKFQTMGNLANQELLIRPSLETLILD-----HCEINSIHGRSPLSGLINIR 192
L LDLS N+ +++ L+ L+TL+L+ H ++ + + L L
Sbjct: 139 DLLYLDLSENRLESLP--PQMRRLVH--LQTLVLNGNPLLHAQLRQLPAMTALQTLHLRS 194
Query: 193 VLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASS 252
+ N ++ L S+L + +S +LT + L LPSL L +S+N EL+
Sbjct: 195 TQRTQSNLPTSLEGL--SNLADVDLSCNDLTRVPEC-LYTLPSLRRLNLSSNQITELSLC 251
Query: 253 ANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLE-SNAFANNTELEYLDL 311
+ + + L + L+K LN N + + + T LE
Sbjct: 252 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMA 311
Query: 312 SNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPE 345
+NNN+ + R K L+ L L+ N + +PE
Sbjct: 312 ANNNLELVPESLCRCPK-LRKLVLNKNHLVTLPE 344
Score = 60.5 bits (140), Expect = 2e-08
Identities = 77/275 (28%), Positives = 130/275 (47%), Gaps = 37/275 (13%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLN 126
L++S+N+ T+ P L N++ L++S N + +P+ NLT L L+LS N +S
Sbjct: 96 LDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLES--- 152
Query: 127 LNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLS 186
L P + HL+ L L+ N + + ++L +L+TL L + + + L
Sbjct: 153 LPPQ--MRRLVHLQTLVLNGN---PLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 207
Query: 187 GLINIRVLKLNFNPLLRIQNLISS--SLRSLFVSNCELT---------------SLNHNE 229
GL N+ + L+ N L R+ + + SLR L +S+ ++T +L+ N+
Sbjct: 208 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 267
Query: 230 LMFLPS----LTHLK--MSNNYRLE---LASSANNLFSQSLKYIDISYCNILQPNLKGFP 280
L LPS L+ LK N+ +L+ L S L + + ++ +L P
Sbjct: 268 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 327
Query: 281 SLRKAILNHN-MVRYLESNAFANNTELEYLDLSNN 314
LRK +LN N +V E+ F TE+E LD+ N
Sbjct: 328 KLRKLVLNKNHLVTLPEAIHFL--TEIEVLDVREN 360
Score = 48.4 bits (110), Expect = 9e-05
Identities = 43/150 (28%), Positives = 72/150 (48%), Gaps = 6/150 (4%)
Query: 310 DLSNNNIASLRY-DTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV- 367
DLS N+ + + + + L+ L L+ + +PE+ L + L L +S N L+ +
Sbjct: 1 DLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEE-LAALQKLEHLSVSHNNLTTLH 59
Query: 368 GHLRSM-SVTILDMSSCELNTIG-KDSLEGLQSIVELDLSQNLLSYIPDSI-SSNTLKYL 424
G L S+ S+ + + L G D + L + LDLS N L+ P + ++ + L
Sbjct: 60 GELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 119
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNR 454
NL++N I +I N F L L L + NR
Sbjct: 120 NLSHNSIDTIPNQLFINLTDLLYLDLSENR 149
Score = 41.5 bits (93), Expect = 0.011
Identities = 26/80 (32%), Positives = 45/80 (56%), Gaps = 3/80 (3%)
Query: 45 DIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPD 102
D+D S LT +P L + +LN+S+N+ T+ + + ++ L++S NQL LP
Sbjct: 214 DVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLP- 272
Query: 103 NALYNLTALEVLNLSRNYFD 122
+A+ L+ L+ L L+ N D
Sbjct: 273 SAICKLSKLKKLYLNSNKLD 292
Score = 35.1 bits (77), Expect = 0.92
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 3/60 (5%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQL--KGLPDNALYNLTALEVLNLSRN 119
+ V LN+S N+ T P ++ +L L L ++SN+L GLP + + LT LE + N
Sbjct: 256 VHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLP-SGIGKLTNLEEFMAANN 314
>AB060695-1|BAB43955.1| 858|Homo sapiens Toll-like receptor 5
protein.
Length = 858
Score = 72.5 bits (170), Expect = 5e-12
Identities = 112/437 (25%), Positives = 202/437 (46%), Gaps = 47/437 (10%)
Query: 64 VTKLNISNNEFTKF--PESLSRLHNLVNLDISSNQLKGLPDNALYNLTA--LEVLNLSRN 119
+T+L++S N+ S +L++L ++D SSNQ+ + ++ L L L +L+ N
Sbjct: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAAN 206
Query: 120 YFDSWLNLNPNDVLLPATH--LKILDLSFNKFQT--MGNLANQELLIRPSLETLILDHCE 175
S ++++ + P + L+ILD+S N + GN +N + + +LIL H
Sbjct: 207 SLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNA--ISKSQAFSLILAH-- 262
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
H G NI+ N L SS+R L +S+ + SLN L
Sbjct: 263 ----HIMGAGFGFHNIKDPDQN-----TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKD 313
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL----QPNLKGFPSLRKAILNHNM 291
L L ++ N ++A A +L+ +++SY N+L N G P + L N
Sbjct: 314 LKVLNLAYNKINKIADEAFYGLD-NLQVLNLSY-NLLGELYSSNFYGLPKVAYIDLQKNH 371
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL-E 350
+ ++ F +L+ LDL +N + ++ + + + + LS N++ +P+ +L
Sbjct: 372 IAIIQDQTFKFLEKLQTLDLRDNALTTIHF-----IPSIPDIFLSGNKLVTLPKINLTAN 426
Query: 351 MPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKD--SLEGL---QSIVE 401
+ L++ +L +L RV HL+ + + SSC + + SLE L +++++
Sbjct: 427 LIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQ 486
Query: 402 LDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L L + + +S L+ L LN+N ++S+ F L L LS+ NR T++
Sbjct: 487 LAWETELCWDVFEGLSH--LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL--- 541
Query: 462 SFFDSNPYLERLDLSDN 478
S D LE LD+S N
Sbjct: 542 SHNDLPANLEILDISRN 558
Score = 66.9 bits (156), Expect = 2e-10
Identities = 54/216 (25%), Positives = 105/216 (48%), Gaps = 7/216 (3%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
S+R L+H V L S F +L+ L+L+ N I + + F GL L+ L+LS+N +
Sbjct: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD-MSSCELNTIGKDSLEGLQSI 399
+ + +P + + L +N+++ + + + L+ + + +L ++ + SI
Sbjct: 349 GELYSSNFYGLPKVAYIDLQKNHIAII---QDQTFKFLEKLQTLDLRDNALTTIHFIPSI 405
Query: 400 VELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFM-LNRLTSLSVVGNRFTMI 458
++ LS N L +P + T ++L+ NR+ +++ L F + + L L + NRF+
Sbjct: 406 PDIFLSGNKLVTLPKI--NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSC 463
Query: 459 WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
NP LE+L L +NM + E D ++
Sbjct: 464 SGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499
Score = 46.4 bits (105), Expect = 4e-04
Identities = 69/267 (25%), Positives = 115/267 (43%), Gaps = 23/267 (8%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLN----PN--DVLLPAT 137
L +L L+++ N++ + D A Y L L+VLNLS N + N P + L
Sbjct: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370
Query: 138 HLKIL-DLSF---NKFQTMGNLANQELLIR--PSLETLILDHCEINSIHGRSPLSGLINI 191
H+ I+ D +F K QT+ N I PS+ + L ++ ++ + + LI++
Sbjct: 371 HIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHL 430
Query: 192 RVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNEL-MFLPSLTHLKMSNN-----Y 245
+L +L L L+ L ++ +S + ++ PSL L + N +
Sbjct: 431 SENRLENLDILYFL-LRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAW 489
Query: 246 RLELASSA-NNLFSQSLKYIDISYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANN 303
EL L + Y++ +Y N L P + +LR LN N + L N N
Sbjct: 490 ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPAN 549
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKML 330
LE LD+S N + + D F L +L
Sbjct: 550 --LEILDISRNQLLAPNPDVFVSLSVL 574
Score = 40.3 bits (90), Expect = 0.024
Identities = 66/254 (25%), Positives = 109/254 (42%), Gaps = 20/254 (7%)
Query: 67 LNISNNEFTK-FPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWL 125
LN+S N + + + L + +D+ N + + D L L+ L+L N + +
Sbjct: 341 LNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTT-I 399
Query: 126 NLNPN--DVLLPATHLKIL---DLSFNKFQTMGN-LANQELL---IR-PSLETLILDHCE 175
+ P+ D+ L L L +L+ N N L N ++L +R P L+ LIL+
Sbjct: 400 HFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNR 459
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPL-LRIQNLISSSLRSLFVSNCELTSLNHNELMFLP 234
+S G S ++ L L N L L + + + +S+ ++ LNHN L LP
Sbjct: 460 FSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE-GLSHLQVLYLNHNYLNSLP 518
Query: 235 S--LTHLKMSNNYRLE---LASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNH 289
+HL L L ++N +L+ +DIS +L PN F SL + H
Sbjct: 519 PGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITH 578
Query: 290 N-MVRYLESNAFAN 302
N + E + F N
Sbjct: 579 NKFICECELSTFIN 592
Score = 39.5 bits (88), Expect = 0.043
Identities = 55/225 (24%), Positives = 108/225 (48%), Gaps = 27/225 (12%)
Query: 268 YCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL-SNNNIASLRYDTFR 325
+CN+ Q P + + + +L+ N +R + +++F +L+ L+L S ++ + FR
Sbjct: 35 FCNLTQVPQVLN--TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFR 92
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS----RVGHLRSM-SVTILDM 380
L L+ LDL ++I + D+ + L +L+L LS + G+ R++ ++T LD+
Sbjct: 93 NLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDL 152
Query: 381 SSCELNTIG-KDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTF 439
S ++ ++ S L S+ +D S N + + + + L+ L L+F
Sbjct: 153 SKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCE----HELEPLQGK--------TLSF 200
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFD-SNPYLERLDLSDNMWRCD 483
F L + + + +R ++ W + N LE LD+S N W D
Sbjct: 201 FSL----AANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVD 241
>DQ084202-1|AAY86709.1| 640|Homo sapiens netrin-G1 ligand splice
variant 4 protein.
Length = 640
Score = 72.1 bits (169), Expect = 7e-12
Identities = 62/204 (30%), Positives = 94/204 (46%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L+ N +R +E AF L+L +N +A++ F L LK L L N I IP
Sbjct: 107 LSRNHIRTIEIGAFNGPANPNTLELFDNRLATIPNGAFVYLSKLKELWLRNNPIESIPSY 166
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L +Y+S ++ L+++ C L I +L L + EL
Sbjct: 167 AFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREI--PNLTPLIKLDEL 224
Query: 403 DLSQNLLSYI-PDSISSNT-LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
DLS N LS I P S L+ L + ++I I F L L +++ N T++
Sbjct: 225 DLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIRVIERNAFDNLQSLVEINLAHNNLTLL-P 283
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F +LER+ L N W C+C
Sbjct: 284 HDLFTPLHHLERIHLHHNPWNCNC 307
Score = 70.5 bits (165), Expect = 2e-11
Identities = 59/216 (27%), Positives = 107/216 (49%), Gaps = 10/216 (4%)
Query: 272 LQPNLKGFP-----SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRG 326
++ NL+G P + R L+ N ++ ++ N+F + LE L LS N+I ++ F G
Sbjct: 63 VRKNLRGVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNG 122
Query: 327 LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSC 383
L+L N +A IP + + + L +L L N + + R S+ LD+
Sbjct: 123 PANPNTLELFDNRLATIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGEL 182
Query: 384 E-LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFML 442
+ L+ I + + EGL ++ L+L+ L IP+ L L+L+ N +S+I +F L
Sbjct: 183 KRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGL 242
Query: 443 NRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L L ++ ++ +I R+ FD+ L ++L+ N
Sbjct: 243 MHLQKLWMIQSQIRVI-ERNAFDNLQSLVEINLAHN 277
Score = 64.5 bits (150), Expect = 1e-09
Identities = 58/230 (25%), Positives = 111/230 (48%), Gaps = 10/230 (4%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--RLELASSANNLFSQSLKYID 265
IS++ R L + ++ + N L L L++S N+ +E+ + +L+ D
Sbjct: 74 ISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGPANPNTLELFD 133
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIASLRYDTF 324
I L++ L +N + + S AF L LDL ++ + F
Sbjct: 134 NRLATIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAF 193
Query: 325 RGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS--RVGHLRS-MSVTILDMS 381
GL L++L+L+ + IP +L + L +L LS N+LS R G + M + L M
Sbjct: 194 EGLSNLRYLNLAMCNLREIP--NLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMI 251
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS--NTLKYLNLNYN 429
++ I +++ + LQS+VE++L+ N L+ +P + + + L+ ++L++N
Sbjct: 252 QSQIRVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
Score = 58.0 bits (134), Expect = 1e-07
Identities = 69/261 (26%), Positives = 111/261 (42%), Gaps = 15/261 (5%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISS 94
+C C+ + + C R+ L +P+G+ LN+ N+ S L +L L +S
Sbjct: 50 VCSCSNQFSKVICVRKNLRGVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSR 109
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N ++ + A L L FD+ L PN + + LK L L N +++ +
Sbjct: 110 NHIRTIEIGAFNGPANPNTLEL----FDNRLATIPNGAFVYLSKLKELWLRNNPIESIPS 165
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS-SSLR 213
A + PSL L L + S GL N+R L L L I NL L
Sbjct: 166 YAFNRI---PSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLD 222
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKM-SNNYRLELASSANNLFSQSLKYIDISYCNI- 271
L +S L+++ L L L M + R+ ++ +NL QSL I++++ N+
Sbjct: 223 ELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIRVIERNAFDNL--QSLVEINLAHNNLT 280
Query: 272 LQPNLKGFP--SLRKAILNHN 290
L P+ P L + L+HN
Sbjct: 281 LLPHDLFTPLHHLERIHLHHN 301
Score = 50.4 bits (115), Expect = 2e-05
Identities = 72/276 (26%), Positives = 122/276 (44%), Gaps = 30/276 (10%)
Query: 63 QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
Q +K+ P+ +S L+NL NQ++ + N+ +L LE+L LSRN+
Sbjct: 56 QFSKVICVRKNLRGVPDGISTNTRLLNLH--ENQIQIIKVNSFKHLRHLEILQLSRNHIR 113
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGR 182
+ N P T L+L N+ T+ N A + L+ L L + I SI
Sbjct: 114 TIEIGAFNGPANPNT----LELFDNRLATIPNGA---FVYLSKLKELWLRNNPIESIPSY 166
Query: 183 SPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMS 242
+ + + ++R +L+ L R+ + + L SN +L L +P+LT L
Sbjct: 167 A-FNRIPSLR--RLDLGELKRLSYISEGAFEGL--SNLRYLNLAMCNLREIPNLTPLIKL 221
Query: 243 NNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFAN 302
+ EL S N+L + I + +G L+K + + +R +E NAF N
Sbjct: 222 D----ELDLSGNHLSA------------IRPGSFQGLMHLQKLWMIQSQIRVIERNAFDN 265
Query: 303 NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
L ++L++NN+ L +D F L L+ + L N
Sbjct: 266 LQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
>BC117276-1|AAI17277.1| 420|Homo sapiens reticulon 4 receptor-like
2 protein.
Length = 420
Score = 72.1 bits (169), Expect = 7e-12
Identities = 63/211 (29%), Positives = 102/211 (48%), Gaps = 9/211 (4%)
Query: 280 PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE 339
PS ++ L +N++R L F +N L L L +NN++++ TFR L+ L+ LDL N
Sbjct: 60 PSTQRLFLQNNLIRTLRPGTFGSN--LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNR 117
Query: 340 -IAVIPEDSLLEMPSLTQLKLSRNYLSRV-GHL-RSM-SVTILDMSSCELNTIGKDSLEG 395
+ + D+ + L L L R LS + G++ R + S+ L + L + D
Sbjct: 118 HLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFAD 177
Query: 396 LQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
L ++ L L N L + + + +L L L+ NR+ ++ F L+RLT L + N
Sbjct: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237
Query: 454 RFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
+ + D P LE L L+ N W CDC
Sbjct: 238 SLASLPGEALADL-PSLEFLRLNANPWACDC 267
Score = 58.0 bits (134), Expect = 1e-07
Identities = 58/215 (26%), Positives = 99/215 (46%), Gaps = 9/215 (4%)
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
N ++ L + PS + L L + I ++ + S L+ + + N + + +L
Sbjct: 50 NFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALE 109
Query: 214 SLFVS-NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ--SLKYIDISYCN 270
L + N L SL + L L L + YR +L+S N+F SL+Y+ + +
Sbjct: 110 ELDLGDNRHLRSLEPDTFQGLERLQSLHL---YRCQLSSLPGNIFRGLVSLQYLYLQENS 166
Query: 271 IL--QPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL 327
+L Q +L +L L+ N +R L + F L+ L L N + + FRGL
Sbjct: 167 LLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGL 226
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
L L L N +A +P ++L ++PSL L+L+ N
Sbjct: 227 SRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Score = 50.4 bits (115), Expect = 2e-05
Identities = 51/179 (28%), Positives = 82/179 (45%), Gaps = 9/179 (5%)
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPN-LKGFPSLRKAILNHNM 291
LT SNN + +L Q+L+ +D+ + L+P+ +G L+ L
Sbjct: 85 LTLWLFSNNLSTIYPGTFRHL--QALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQ 142
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ L N F L+YL L N++ L+ D F L L HL L N + ++ E +
Sbjct: 143 LSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGL 202
Query: 352 PSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
SL +L L N L V R +S +TIL + + L ++ ++L L S+ L L+ N
Sbjct: 203 GSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Score = 37.1 bits (82), Expect = 0.23
Identities = 66/262 (25%), Positives = 107/262 (40%), Gaps = 41/262 (15%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISS 94
LC C + C + +P L +L + NN T P + NL+ L + S
Sbjct: 34 LCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFS 91
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N L + +L ALE L+L N HL+ L+ + FQ +
Sbjct: 92 NNLSTIYPGTFRHLQALEELDLGDN-----------------RHLRSLEP--DTFQGLER 132
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
L ++L L C+++S+ G + GL++++ L L N LL +Q+ + + L +
Sbjct: 133 L-----------QSLHLYRCQLSSLPG-NIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
Query: 215 ---LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA--NNLFSQSLKYI-DISY 268
LF+ L L + L SL L + N RL+ A L ++ Y+ + S
Sbjct: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGN-RLQGVHRAAFRGLSRLTILYLFNNSL 239
Query: 269 CNILQPNLKGFPSLRKAILNHN 290
++ L PSL LN N
Sbjct: 240 ASLPGEALADLPSLEFLRLNAN 261
Score = 32.3 bits (70), Expect = 6.5
Identities = 37/119 (31%), Positives = 49/119 (41%), Gaps = 6/119 (5%)
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYI-PDSISSNTLKYLNLNYNRISSINNLTFF 440
SC+ N L S L L NL+ + P + SN L L L N +S+I TF
Sbjct: 45 SCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLT-LWLFSNNLSTIYPGTFR 103
Query: 441 MLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLE 499
L L L + NR F LERL S +++RC S F V+L+
Sbjct: 104 HLQALEELDLGDNRHLRSLEPDTFQG---LERLQ-SLHLYRCQLSSLPGNIFRGLVSLQ 158
>BC113673-1|AAI13674.1| 420|Homo sapiens reticulon 4 receptor-like
2 protein.
Length = 420
Score = 72.1 bits (169), Expect = 7e-12
Identities = 63/211 (29%), Positives = 102/211 (48%), Gaps = 9/211 (4%)
Query: 280 PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE 339
PS ++ L +N++R L F +N L L L +NN++++ TFR L+ L+ LDL N
Sbjct: 60 PSTQRLFLQNNLIRTLRPGTFGSN--LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNR 117
Query: 340 -IAVIPEDSLLEMPSLTQLKLSRNYLSRV-GHL-RSM-SVTILDMSSCELNTIGKDSLEG 395
+ + D+ + L L L R LS + G++ R + S+ L + L + D
Sbjct: 118 HLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFAD 177
Query: 396 LQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
L ++ L L N L + + + +L L L+ NR+ ++ F L+RLT L + N
Sbjct: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237
Query: 454 RFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
+ + D P LE L L+ N W CDC
Sbjct: 238 SLASLPGEALADL-PSLEFLRLNANPWACDC 267
Score = 58.0 bits (134), Expect = 1e-07
Identities = 58/215 (26%), Positives = 99/215 (46%), Gaps = 9/215 (4%)
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
N ++ L + PS + L L + I ++ + S L+ + + N + + +L
Sbjct: 50 NFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALE 109
Query: 214 SLFVS-NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ--SLKYIDISYCN 270
L + N L SL + L L L + YR +L+S N+F SL+Y+ + +
Sbjct: 110 ELDLGDNRHLRSLEPDTFQGLERLQSLHL---YRCQLSSLPGNIFRGLVSLQYLYLQENS 166
Query: 271 IL--QPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL 327
+L Q +L +L L+ N +R L + F L+ L L N + + FRGL
Sbjct: 167 LLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGL 226
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
L L L N +A +P ++L ++PSL L+L+ N
Sbjct: 227 SRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Score = 50.4 bits (115), Expect = 2e-05
Identities = 51/179 (28%), Positives = 82/179 (45%), Gaps = 9/179 (5%)
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPN-LKGFPSLRKAILNHNM 291
LT SNN + +L Q+L+ +D+ + L+P+ +G L+ L
Sbjct: 85 LTLWLFSNNLSTIYPGTFRHL--QALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQ 142
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ L N F L+YL L N++ L+ D F L L HL L N + ++ E +
Sbjct: 143 LSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGL 202
Query: 352 PSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
SL +L L N L V R +S +TIL + + L ++ ++L L S+ L L+ N
Sbjct: 203 GSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Score = 37.1 bits (82), Expect = 0.23
Identities = 66/262 (25%), Positives = 107/262 (40%), Gaps = 41/262 (15%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISS 94
LC C + C + +P L +L + NN T P + NL+ L + S
Sbjct: 34 LCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFS 91
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N L + +L ALE L+L N HL+ L+ + FQ +
Sbjct: 92 NNLSTIYPGTFRHLQALEELDLGDN-----------------RHLRSLEP--DTFQGLER 132
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
L ++L L C+++S+ G + GL++++ L L N LL +Q+ + + L +
Sbjct: 133 L-----------QSLHLYRCQLSSLPG-NIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
Query: 215 ---LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA--NNLFSQSLKYI-DISY 268
LF+ L L + L SL L + N RL+ A L ++ Y+ + S
Sbjct: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGN-RLQGVHRAAFRGLSRLTILYLFNNSL 239
Query: 269 CNILQPNLKGFPSLRKAILNHN 290
++ L PSL LN N
Sbjct: 240 ASLPGEALADLPSLEFLRLNAN 261
Score = 32.3 bits (70), Expect = 6.5
Identities = 37/119 (31%), Positives = 49/119 (41%), Gaps = 6/119 (5%)
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYI-PDSISSNTLKYLNLNYNRISSINNLTFF 440
SC+ N L S L L NL+ + P + SN L L L N +S+I TF
Sbjct: 45 SCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLT-LWLFSNNLSTIYPGTFR 103
Query: 441 MLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLE 499
L L L + NR F LERL S +++RC S F V+L+
Sbjct: 104 HLQALEELDLGDNRHLRSLEPDTFQG---LERLQ-SLHLYRCQLSSLPGNIFRGLVSLQ 158
>AF532858-1|AAP21835.1| 420|Homo sapiens Nogo-66 receptor homolog-1
protein.
Length = 420
Score = 72.1 bits (169), Expect = 7e-12
Identities = 63/211 (29%), Positives = 102/211 (48%), Gaps = 9/211 (4%)
Query: 280 PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE 339
PS ++ L +N++R L F +N L L L +NN++++ TFR L+ L+ LDL N
Sbjct: 60 PSTQRLFLQNNLIRTLRPGTFGSN--LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNR 117
Query: 340 -IAVIPEDSLLEMPSLTQLKLSRNYLSRV-GHL-RSM-SVTILDMSSCELNTIGKDSLEG 395
+ + D+ + L L L R LS + G++ R + S+ L + L + D
Sbjct: 118 HLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFAD 177
Query: 396 LQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
L ++ L L N L + + + +L L L+ NR+ ++ F L+RLT L + N
Sbjct: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237
Query: 454 RFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
+ + D P LE L L+ N W CDC
Sbjct: 238 SLASLPGEALADL-PSLEFLRLNANPWACDC 267
Score = 58.0 bits (134), Expect = 1e-07
Identities = 58/215 (26%), Positives = 99/215 (46%), Gaps = 9/215 (4%)
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
N ++ L + PS + L L + I ++ + S L+ + + N + + +L
Sbjct: 50 NFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALE 109
Query: 214 SLFVS-NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ--SLKYIDISYCN 270
L + N L SL + L L L + YR +L+S N+F SL+Y+ + +
Sbjct: 110 ELDLGDNRHLRSLEPDTFQGLERLQSLHL---YRCQLSSLPGNIFRGLVSLQYLYLQENS 166
Query: 271 IL--QPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL 327
+L Q +L +L L+ N +R L + F L+ L L N + + FRGL
Sbjct: 167 LLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGL 226
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
L L L N +A +P ++L ++PSL L+L+ N
Sbjct: 227 SRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Score = 50.4 bits (115), Expect = 2e-05
Identities = 51/179 (28%), Positives = 82/179 (45%), Gaps = 9/179 (5%)
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPN-LKGFPSLRKAILNHNM 291
LT SNN + +L Q+L+ +D+ + L+P+ +G L+ L
Sbjct: 85 LTLWLFSNNLSTIYPGTFRHL--QALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQ 142
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ L N F L+YL L N++ L+ D F L L HL L N + ++ E +
Sbjct: 143 LSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGL 202
Query: 352 PSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
SL +L L N L V R +S +TIL + + L ++ ++L L S+ L L+ N
Sbjct: 203 GSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Score = 37.1 bits (82), Expect = 0.23
Identities = 66/262 (25%), Positives = 107/262 (40%), Gaps = 41/262 (15%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISS 94
LC C + C + +P L +L + NN T P + NL+ L + S
Sbjct: 34 LCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFS 91
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N L + +L ALE L+L N HL+ L+ + FQ +
Sbjct: 92 NNLSTIYPGTFRHLQALEELDLGDN-----------------RHLRSLEP--DTFQGLER 132
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
L ++L L C+++S+ G + GL++++ L L N LL +Q+ + + L +
Sbjct: 133 L-----------QSLHLYRCQLSSLPG-NIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
Query: 215 ---LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA--NNLFSQSLKYI-DISY 268
LF+ L L + L SL L + N RL+ A L ++ Y+ + S
Sbjct: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGN-RLQGVHRAAFRGLSRLTILYLFNNSL 239
Query: 269 CNILQPNLKGFPSLRKAILNHN 290
++ L PSL LN N
Sbjct: 240 ASLPGEALADLPSLEFLRLNAN 261
Score = 32.3 bits (70), Expect = 6.5
Identities = 37/119 (31%), Positives = 49/119 (41%), Gaps = 6/119 (5%)
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYI-PDSISSNTLKYLNLNYNRISSINNLTFF 440
SC+ N L S L L NL+ + P + SN L L L N +S+I TF
Sbjct: 45 SCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLT-LWLFSNNLSTIYPGTFR 103
Query: 441 MLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLE 499
L L L + NR F LERL S +++RC S F V+L+
Sbjct: 104 HLQALEELDLGDNRHLRSLEPDTFQG---LERLQ-SLHLYRCQLSSLPGNIFRGLVSLQ 158
>BC130290-1|AAI30291.1| 660|Homo sapiens fibronectin leucine rich
transmembrane protein 2 protein.
Length = 660
Score = 71.7 bits (168), Expect = 9e-12
Identities = 75/306 (24%), Positives = 134/306 (43%), Gaps = 17/306 (5%)
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF 279
C SL L +T L + NN ++ A L + + Y N L
Sbjct: 49 CNERSLTSVPLGIPEGVTVLYLHNN-QINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNL 107
Query: 280 P-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD--TFRGLKMLKHLDLS 336
P ++R L N ++ + A A +LE L L +N+I+++ + FR LK L LS
Sbjct: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLS 167
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI-GKDSLEG 395
N ++ +P ++ L +L++ N ++ + + ++T L+ + N + K EG
Sbjct: 168 KNHLSSVPVGLPVD---LQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEG 224
Query: 396 ----LQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
L + E + +N LS+ P + L L L N+I+ I F L +L L +
Sbjct: 225 TFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDIS 284
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLIC 511
N+ M+ + FD+ L++L +N W CDCS + + ++ ++ N + +C
Sbjct: 285 NNQLRML-TQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVR----GFMC 339
Query: 512 NSPANV 517
P V
Sbjct: 340 QGPEQV 345
Score = 63.3 bits (147), Expect = 3e-09
Identities = 77/300 (25%), Positives = 129/300 (43%), Gaps = 35/300 (11%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK--FPESLSRLHNLVNLDIS 93
+CRC D+ + C+ R LT +P G+ VT L + NN+ FP L + ++ + +
Sbjct: 39 VCRC--DRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLY 96
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
NQL P N N + VL+L N + L L+ L L N T+G
Sbjct: 97 GNQLDEFPMNLPKN---VRVLHLQENN----IQTISRAALAQLLKLEELHLDDNSISTVG 149
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + SL+ L L ++S+ P+ ++++ L+++ N + I ++ +L
Sbjct: 150 -VEDGAFREAISLKLLFLSKNHLSSV----PVGLPVDLQELRVDENRIAVISDMAFQNLT 204
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ 273
SL E ++ N L+ + S+ +L+ S N S
Sbjct: 205 SL-----ERLIVDGN-LLTNKGIAEGTFSHLTKLKEFSIVRNSLSHP------------P 246
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
P+L G L + L N + ++ AF+N +LE LD+SNN + L F L LK L
Sbjct: 247 PDLPG-THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQL 305
Score = 36.7 bits (81), Expect = 0.30
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
Query: 50 RRGLTDIPNGL-GLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYN 107
R L+ P L G + +L + +N+ P + S L L LDIS+NQL+ L N
Sbjct: 239 RNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDN 298
Query: 108 LTALEVLNLSRN 119
L+ L+ L N
Sbjct: 299 LSNLKQLTARNN 310
>BC126249-1|AAI26250.1| 660|Homo sapiens fibronectin leucine rich
transmembrane protein 2 protein.
Length = 660
Score = 71.7 bits (168), Expect = 9e-12
Identities = 75/306 (24%), Positives = 134/306 (43%), Gaps = 17/306 (5%)
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF 279
C SL L +T L + NN ++ A L + + Y N L
Sbjct: 49 CNERSLTSVPLGIPEGVTVLYLHNN-QINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNL 107
Query: 280 P-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD--TFRGLKMLKHLDLS 336
P ++R L N ++ + A A +LE L L +N+I+++ + FR LK L LS
Sbjct: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLS 167
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI-GKDSLEG 395
N ++ +P ++ L +L++ N ++ + + ++T L+ + N + K EG
Sbjct: 168 KNHLSSVPVGLPVD---LQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEG 224
Query: 396 ----LQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
L + E + +N LS+ P + L L L N+I+ I F L +L L +
Sbjct: 225 TFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDIS 284
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLIC 511
N+ M+ + FD+ L++L +N W CDCS + + ++ ++ N + +C
Sbjct: 285 NNQLRML-TQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVR----GFMC 339
Query: 512 NSPANV 517
P V
Sbjct: 340 QGPEQV 345
Score = 63.3 bits (147), Expect = 3e-09
Identities = 77/300 (25%), Positives = 129/300 (43%), Gaps = 35/300 (11%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK--FPESLSRLHNLVNLDIS 93
+CRC D+ + C+ R LT +P G+ VT L + NN+ FP L + ++ + +
Sbjct: 39 VCRC--DRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLY 96
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
NQL P N N + VL+L N + L L+ L L N T+G
Sbjct: 97 GNQLDEFPMNLPKN---VRVLHLQENN----IQTISRAALAQLLKLEELHLDDNSISTVG 149
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + SL+ L L ++S+ P+ ++++ L+++ N + I ++ +L
Sbjct: 150 -VEDGAFREAISLKLLFLSKNHLSSV----PVGLPVDLQELRVDENRIAVISDMAFQNLT 204
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ 273
SL E ++ N L+ + S+ +L+ S N S
Sbjct: 205 SL-----ERLIVDGN-LLTNKGIAEGTFSHLTKLKEFSIVRNSLSHP------------P 246
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
P+L G L + L N + ++ AF+N +LE LD+SNN + L F L LK L
Sbjct: 247 PDLPG-THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQL 305
Score = 36.7 bits (81), Expect = 0.30
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
Query: 50 RRGLTDIPNGL-GLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYN 107
R L+ P L G + +L + +N+ P + S L L LDIS+NQL+ L N
Sbjct: 239 RNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDN 298
Query: 108 LTALEVLNLSRN 119
L+ L+ L N
Sbjct: 299 LSNLKQLTARNN 310
>BC109119-1|AAI09120.1| 858|Homo sapiens TLR5 protein protein.
Length = 858
Score = 71.7 bits (168), Expect = 9e-12
Identities = 112/437 (25%), Positives = 201/437 (45%), Gaps = 47/437 (10%)
Query: 64 VTKLNISNNEFTKF--PESLSRLHNLVNLDISSNQLKGLPDNALYNLTA--LEVLNLSRN 119
+T+L++S N+ S +L++L ++D SSNQ+ + ++ L L L +L+ N
Sbjct: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAAN 206
Query: 120 YFDSWLNLNPNDVLLPATH--LKILDLSFNKFQT--MGNLANQELLIRPSLETLILDHCE 175
S ++++ + P + L+ILD+S N + GN +N + + +LIL H
Sbjct: 207 SLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNA--ISKSQAFSLILAH-- 262
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
H G NI+ N L SS+R L +S+ + SLN L
Sbjct: 263 ----HIMGAGFGFHNIKDPDQN-----TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKD 313
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL----QPNLKGFPSLRKAILNHNM 291
L L ++ N ++A A +L+ +++SY N+L N G P + L N
Sbjct: 314 LKVLNLAYNKINKIADEAFYGLD-NLQVLNLSY-NLLGELYSSNFYGLPKVAYIDLQKNH 371
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL-E 350
+ ++ F +L LDL +N + ++ + + + + LS N++ +P+ +L
Sbjct: 372 IAIIQDQTFKFLEKLRTLDLRDNALTTIHF-----IPSIPDIFLSGNKLVTLPKINLTAN 426
Query: 351 MPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKD--SLEGL---QSIVE 401
+ L++ +L +L RV HL+ + + SSC + + SLE L +++++
Sbjct: 427 LIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQ 486
Query: 402 LDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L L + + +S L+ L LN+N ++S+ F L L LS+ NR T++
Sbjct: 487 LAWETELCWDVFEGLSH--LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL--- 541
Query: 462 SFFDSNPYLERLDLSDN 478
S D LE LD+S N
Sbjct: 542 SHNDLPANLEILDISRN 558
Score = 66.5 bits (155), Expect = 3e-10
Identities = 54/216 (25%), Positives = 105/216 (48%), Gaps = 7/216 (3%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
S+R L+H V L S F +L+ L+L+ N I + + F GL L+ L+LS+N +
Sbjct: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD-MSSCELNTIGKDSLEGLQSI 399
+ + +P + + L +N+++ + + + L+ + + +L ++ + SI
Sbjct: 349 GELYSSNFYGLPKVAYIDLQKNHIAII---QDQTFKFLEKLRTLDLRDNALTTIHFIPSI 405
Query: 400 VELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFM-LNRLTSLSVVGNRFTMI 458
++ LS N L +P + T ++L+ NR+ +++ L F + + L L + NRF+
Sbjct: 406 PDIFLSGNKLVTLPKI--NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSC 463
Query: 459 WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
NP LE+L L +NM + E D ++
Sbjct: 464 SGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499
Score = 44.8 bits (101), Expect = 0.001
Identities = 68/267 (25%), Positives = 114/267 (42%), Gaps = 23/267 (8%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLN----PNDVL--LPAT 137
L +L L+++ N++ + D A Y L L+VLNLS N + N P L
Sbjct: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370
Query: 138 HLKIL-DLSFN---KFQTMGNLANQELLIR--PSLETLILDHCEINSIHGRSPLSGLINI 191
H+ I+ D +F K +T+ N I PS+ + L ++ ++ + + LI++
Sbjct: 371 HIAIIQDQTFKFLEKLRTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHL 430
Query: 192 RVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFL-PSLTHLKMSNN-----Y 245
+L +L L L+ L ++ +S + ++ PSL L + N +
Sbjct: 431 SENRLENLDILYFL-LRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAW 489
Query: 246 RLELASSA-NNLFSQSLKYIDISYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANN 303
EL L + Y++ +Y N L P + +LR LN N + L N N
Sbjct: 490 ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPAN 549
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKML 330
LE LD+S N + + D F L +L
Sbjct: 550 --LEILDISRNQLLAPNPDVFVSLSVL 574
Score = 39.5 bits (88), Expect = 0.043
Identities = 55/225 (24%), Positives = 108/225 (48%), Gaps = 27/225 (12%)
Query: 268 YCNILQ-PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL-SNNNIASLRYDTFR 325
+CN+ Q P + + + +L+ N +R + +++F +L+ L+L S ++ + FR
Sbjct: 35 FCNLTQVPQVLN--TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFR 92
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS----RVGHLRSM-SVTILDM 380
L L+ LDL ++I + D+ + L +L+L LS + G+ R++ ++T LD+
Sbjct: 93 NLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDL 152
Query: 381 SSCELNTIG-KDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTF 439
S ++ ++ S L S+ +D S N + + + + L+ L L+F
Sbjct: 153 SKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCE----HELEPLQGK--------TLSF 200
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFD-SNPYLERLDLSDNMWRCD 483
F L + + + +R ++ W + N LE LD+S N W D
Sbjct: 201 FSL----AANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVD 241
Score = 39.5 bits (88), Expect = 0.043
Identities = 63/218 (28%), Positives = 99/218 (45%), Gaps = 30/218 (13%)
Query: 86 NLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLS 145
++ ++ +S N+L LP NLTA +++LS N + NL+ LL HL+IL L+
Sbjct: 404 SIPDIFLSGNKLVTLPK---INLTA-NLIHLSENRLE---NLDILYFLLRVPHLQILILN 456
Query: 146 FNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
N+F + +Q PSLE L L G + L + F L
Sbjct: 457 QNRFSSCSG--DQTPSENPSLEQLFL---------GENMLQLAWETELCWDVFEGL---- 501
Query: 206 NLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYID 265
S L+ L++++ L SL L +L L +++N RL + S +N +L+ +D
Sbjct: 502 ----SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN-RLTVLS--HNDLPANLEILD 554
Query: 266 ISYCNILQPNLKGFPSLRKAILNHN-MVRYLESNAFAN 302
IS +L PN F SL + HN + E + F N
Sbjct: 555 ISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFIN 592
>BC020870-1|AAH20870.1| 649|Homo sapiens fibronectin leucine rich
transmembrane protein 3 protein.
Length = 649
Score = 71.7 bits (168), Expect = 9e-12
Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 23/292 (7%)
Query: 237 THLKMSNNY--RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-LNHNMVR 293
T L + NN + S NL Y+ Y N L P K + L N +R
Sbjct: 61 TTLYLQNNQINNAGIPSDLKNLLKVERIYL---YHNSLDEFPTNLPKYVKELHLQENNIR 117
Query: 294 YLESNAFANNTELEYLDLSNNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ ++ + LE L L +N+++ S+ FR L+ L LS N ++ IP +
Sbjct: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWG----L 173
Query: 352 P-SLTQLKLSRNYLSRVGH-----LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
P ++ +L+L N +S + L S+ +LD + + +G L ++ EL L
Sbjct: 174 PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLV 233
Query: 406 QNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFD 465
+N L+ P ++ L+ L L N I+ + F L +L L + N + + + FD
Sbjct: 234 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL-PQGIFD 292
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANV 517
+ +L L +N W C C + +RD+ + ++ N + L+C +P V
Sbjct: 293 DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVR----GLMCQAPEKV 340
Score = 55.2 bits (127), Expect = 8e-07
Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ R LT IP G+ T L + NN+
Sbjct: 34 VCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN------------------- 72
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L NL +E + L N D + P + LP ++K L L N +T +
Sbjct: 73 --AGIPSD-LKNLLKVERIYLYHNSLDEF----PTN--LPK-YVKELHLQENNIRT---I 119
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISSSLRS 214
L P LE L LD ++++ N +R+L L+ N L I + ++
Sbjct: 120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEE 179
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC-NILQ 273
L + + +++++ L L SL L + N L + +F + ++S N L
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNL-LNNHGLGDKVFFNLVNLTELSLVRNSLT 238
Query: 274 P---NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
NL G +LRK L N + + NAF+ +L LD+SNNN+++L F L +
Sbjct: 239 AAPVNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 297
Query: 331 KHLDLSWN 338
L L N
Sbjct: 298 TQLILRNN 305
>AY358319-1|AAQ88685.1| 649|Homo sapiens FLRT3 protein.
Length = 649
Score = 71.7 bits (168), Expect = 9e-12
Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 23/292 (7%)
Query: 237 THLKMSNNY--RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-LNHNMVR 293
T L + NN + S NL Y+ Y N L P K + L N +R
Sbjct: 61 TTLYLQNNQINNAGIPSDLKNLLKVERIYL---YHNSLDEFPTNLPKYVKELHLQENNIR 117
Query: 294 YLESNAFANNTELEYLDLSNNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ ++ + LE L L +N+++ S+ FR L+ L LS N ++ IP +
Sbjct: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWG----L 173
Query: 352 P-SLTQLKLSRNYLSRVGH-----LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
P ++ +L+L N +S + L S+ +LD + + +G L ++ EL L
Sbjct: 174 PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLV 233
Query: 406 QNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFD 465
+N L+ P ++ L+ L L N I+ + F L +L L + N + + + FD
Sbjct: 234 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL-PQGIFD 292
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANV 517
+ +L L +N W C C + +RD+ + ++ N + L+C +P V
Sbjct: 293 DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVR----GLMCQAPEKV 340
Score = 55.2 bits (127), Expect = 8e-07
Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ R LT IP G+ T L + NN+
Sbjct: 34 VCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN------------------- 72
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L NL +E + L N D + P + LP ++K L L N +T +
Sbjct: 73 --AGIPSD-LKNLLKVERIYLYHNSLDEF----PTN--LPK-YVKELHLQENNIRT---I 119
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISSSLRS 214
L P LE L LD ++++ N +R+L L+ N L I + ++
Sbjct: 120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEE 179
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC-NILQ 273
L + + +++++ L L SL L + N L + +F + ++S N L
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNL-LNNHGLGDKVFFNLVNLTELSLVRNSLT 238
Query: 274 P---NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
NL G +LRK L N + + NAF+ +L LD+SNNN+++L F L +
Sbjct: 239 AAPVNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 297
Query: 331 KHLDLSWN 338
L L N
Sbjct: 298 TQLILRNN 305
>AY358287-1|AAQ88654.1| 660|Homo sapiens FLRT2 protein.
Length = 660
Score = 71.7 bits (168), Expect = 9e-12
Identities = 75/306 (24%), Positives = 134/306 (43%), Gaps = 17/306 (5%)
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF 279
C SL L +T L + NN ++ A L + + Y N L
Sbjct: 49 CNERSLTSVPLGIPEGVTVLYLHNN-QINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNL 107
Query: 280 P-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD--TFRGLKMLKHLDLS 336
P ++R L N ++ + A A +LE L L +N+I+++ + FR LK L LS
Sbjct: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLS 167
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI-GKDSLEG 395
N ++ +P ++ L +L++ N ++ + + ++T L+ + N + K EG
Sbjct: 168 KNHLSSVPVGLPVD---LQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEG 224
Query: 396 ----LQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
L + E + +N LS+ P + L L L N+I+ I F L +L L +
Sbjct: 225 TFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDIS 284
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLIC 511
N+ M+ + FD+ L++L +N W CDCS + + ++ ++ N + +C
Sbjct: 285 NNQLRML-TQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVR----GFMC 339
Query: 512 NSPANV 517
P V
Sbjct: 340 QGPEQV 345
Score = 63.3 bits (147), Expect = 3e-09
Identities = 77/300 (25%), Positives = 129/300 (43%), Gaps = 35/300 (11%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK--FPESLSRLHNLVNLDIS 93
+CRC D+ + C+ R LT +P G+ VT L + NN+ FP L + ++ + +
Sbjct: 39 VCRC--DRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLY 96
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
NQL P N N + VL+L N + L L+ L L N T+G
Sbjct: 97 GNQLDEFPMNLPKN---VRVLHLQENN----IQTISRAALAQLLKLEELHLDDNSISTVG 149
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + SL+ L L ++S+ P+ ++++ L+++ N + I ++ +L
Sbjct: 150 -VEDGAFREAISLKLLFLSKNHLSSV----PVGLPVDLQELRVDENRIAVISDMAFQNLT 204
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ 273
SL E ++ N L+ + S+ +L+ S N S
Sbjct: 205 SL-----ERLIVDGN-LLTNKGIAEGTFSHLTKLKEFSIVRNSLSHP------------P 246
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
P+L G L + L N + ++ AF+N +LE LD+SNN + L F L LK L
Sbjct: 247 PDLPG-THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQL 305
Score = 36.7 bits (81), Expect = 0.30
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
Query: 50 RRGLTDIPNGL-GLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYN 107
R L+ P L G + +L + +N+ P + S L L LDIS+NQL+ L N
Sbjct: 239 RNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDN 298
Query: 108 LTALEVLNLSRN 119
L+ L+ L N
Sbjct: 299 LSNLKQLTARNN 310
>AL132826-1|CAB86687.1| 649|Homo sapiens fibronectin leucine rich
transmembrane protein 3 protein.
Length = 649
Score = 71.7 bits (168), Expect = 9e-12
Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 23/292 (7%)
Query: 237 THLKMSNNY--RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-LNHNMVR 293
T L + NN + S NL Y+ Y N L P K + L N +R
Sbjct: 61 TTLYLQNNQINNAGIPSDLKNLLKVERIYL---YHNSLDEFPTNLPKYVKELHLQENNIR 117
Query: 294 YLESNAFANNTELEYLDLSNNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ ++ + LE L L +N+++ S+ FR L+ L LS N ++ IP +
Sbjct: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWG----L 173
Query: 352 P-SLTQLKLSRNYLSRVGH-----LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
P ++ +L+L N +S + L S+ +LD + + +G L ++ EL L
Sbjct: 174 PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLV 233
Query: 406 QNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFD 465
+N L+ P ++ L+ L L N I+ + F L +L L + N + + + FD
Sbjct: 234 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL-PQGIFD 292
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANV 517
+ +L L +N W C C + +RD+ + ++ N + L+C +P V
Sbjct: 293 DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVR----GLMCQAPEKV 340
Score = 55.2 bits (127), Expect = 8e-07
Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ R LT IP G+ T L + NN+
Sbjct: 34 VCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN------------------- 72
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L NL +E + L N D + P + LP ++K L L N +T +
Sbjct: 73 --AGIPSD-LKNLLKVERIYLYHNSLDEF----PTN--LPK-YVKELHLQENNIRT---I 119
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISSSLRS 214
L P LE L LD ++++ N +R+L L+ N L I + ++
Sbjct: 120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEE 179
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC-NILQ 273
L + + +++++ L L SL L + N L + +F + ++S N L
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNL-LNNHGLGDKVFFNLVNLTELSLVRNSLT 238
Query: 274 P---NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
NL G +LRK L N + + NAF+ +L LD+SNNN+++L F L +
Sbjct: 239 AAPVNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 297
Query: 331 KHLDLSWN 338
L L N
Sbjct: 298 TQLILRNN 305
>AK074909-1|BAC11284.1| 649|Homo sapiens protein ( Homo sapiens
cDNA FLJ90428 fis, clone NT2RP3000616, highly similar to
Leucine-rich repeat transmembrane protein FLRT3
precursor. ).
Length = 649
Score = 71.7 bits (168), Expect = 9e-12
Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 23/292 (7%)
Query: 237 THLKMSNNY--RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-LNHNMVR 293
T L + NN + S NL Y+ Y N L P K + L N +R
Sbjct: 61 TTLYLQNNQINNAGIPSDLKNLLKVERIYL---YHNSLDEFPTNLPKYVKELHLQENNIR 117
Query: 294 YLESNAFANNTELEYLDLSNNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ ++ + LE L L +N+++ S+ FR L+ L LS N ++ IP +
Sbjct: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWG----L 173
Query: 352 P-SLTQLKLSRNYLSRVGH-----LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
P ++ +L+L N +S + L S+ +LD + + +G L ++ EL L
Sbjct: 174 PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLV 233
Query: 406 QNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFD 465
+N L+ P ++ L+ L L N I+ + F L +L L + N + + + FD
Sbjct: 234 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL-PQGIFD 292
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANV 517
+ +L L +N W C C + +RD+ + ++ N + L+C +P V
Sbjct: 293 DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVR----GLMCQAPEKV 340
Score = 55.2 bits (127), Expect = 8e-07
Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ R LT IP G+ T L + NN+
Sbjct: 34 VCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN------------------- 72
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L NL +E + L N D + P + LP ++K L L N +T +
Sbjct: 73 --AGIPSD-LKNLLKVERIYLYHNSLDEF----PTN--LPK-YVKELHLQENNIRT---I 119
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISSSLRS 214
L P LE L LD ++++ N +R+L L+ N L I + ++
Sbjct: 120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEE 179
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC-NILQ 273
L + + +++++ L L SL L + N L + +F + ++S N L
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNL-LNNHGLGDKVFFNLVNLTELSLVRNSLT 238
Query: 274 P---NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
NL G +LRK L N + + NAF+ +L LD+SNNN+++L F L +
Sbjct: 239 AAPVNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 297
Query: 331 KHLDLSWN 338
L L N
Sbjct: 298 TQLILRNN 305
>AK074883-1|BAC11265.1| 627|Homo sapiens protein ( Homo sapiens
cDNA FLJ90402 fis, clone NT2RP2006004, highly similar to
Leucine-rich repeat transmembrane protein FLRT3
precursor. ).
Length = 627
Score = 71.7 bits (168), Expect = 9e-12
Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 23/292 (7%)
Query: 237 THLKMSNNY--RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-LNHNMVR 293
T L + NN + S NL Y+ Y N L P K + L N +R
Sbjct: 61 TTLYLQNNQINNAGIPSDLKNLLKVERIYL---YHNSLDEFPTNLPKYVKELHLQENNIR 117
Query: 294 YLESNAFANNTELEYLDLSNNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ ++ + LE L L +N+++ S+ FR L+ L LS N ++ IP +
Sbjct: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWG----L 173
Query: 352 P-SLTQLKLSRNYLSRVGH-----LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
P ++ +L+L N +S + L S+ +LD + + +G L ++ EL L
Sbjct: 174 PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLV 233
Query: 406 QNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFD 465
+N L+ P ++ L+ L L N I+ + F L +L L + N + + + FD
Sbjct: 234 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL-PQGIFD 292
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANV 517
+ +L L +N W C C + +RD+ + ++ N + L+C +P V
Sbjct: 293 DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVR----GLMCQAPEKV 340
Score = 55.2 bits (127), Expect = 8e-07
Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ R LT IP G+ T L + NN+
Sbjct: 34 VCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN------------------- 72
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L NL +E + L N D + P + LP ++K L L N +T +
Sbjct: 73 --AGIPSD-LKNLLKVERIYLYHNSLDEF----PTN--LPK-YVKELHLQENNIRT---I 119
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISSSLRS 214
L P LE L LD ++++ N +R+L L+ N L I + ++
Sbjct: 120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEE 179
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC-NILQ 273
L + + +++++ L L SL L + N L + +F + ++S N L
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNL-LNNHGLGDKVFFNLVNLTELSLVRNSLT 238
Query: 274 P---NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
NL G +LRK L N + + NAF+ +L LD+SNNN+++L F L +
Sbjct: 239 AAPVNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 297
Query: 331 KHLDLSWN 338
L L N
Sbjct: 298 TQLILRNN 305
>AK027694-1|BAB55303.1| 623|Homo sapiens protein ( Homo sapiens
cDNA FLJ14788 fis, clone NT2RP4000925, weakly similar to
FIBROMODULIN PRECURSOR. ).
Length = 623
Score = 71.7 bits (168), Expect = 9e-12
Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 23/292 (7%)
Query: 237 THLKMSNNY--RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-LNHNMVR 293
T L + NN + S NL Y+ Y N L P K + L N +R
Sbjct: 35 TTLYLQNNQINNAGIPSDLKNLLKVERIYL---YHNSLDEFPTNLPKYVKELHLQENNIR 91
Query: 294 YLESNAFANNTELEYLDLSNNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ ++ + LE L L +N+++ S+ FR L+ L LS N ++ IP +
Sbjct: 92 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWG----L 147
Query: 352 P-SLTQLKLSRNYLSRVGH-----LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
P ++ +L+L N +S + L S+ +LD + + +G L ++ EL L
Sbjct: 148 PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLV 207
Query: 406 QNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFD 465
+N L+ P ++ L+ L L N I+ + F L +L L + N + + + FD
Sbjct: 208 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL-PQGIFD 266
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANV 517
+ +L L +N W C C + +RD+ + ++ N + L+C +P V
Sbjct: 267 DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVR----GLMCQAPEKV 314
Score = 55.2 bits (127), Expect = 8e-07
Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ R LT IP G+ T L + NN+
Sbjct: 8 VCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN------------------- 46
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L NL +E + L N D + P + LP ++K L L N +T +
Sbjct: 47 --AGIPSD-LKNLLKVERIYLYHNSLDEF----PTN--LPK-YVKELHLQENNIRT---I 93
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISSSLRS 214
L P LE L LD ++++ N +R+L L+ N L I + ++
Sbjct: 94 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEE 153
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC-NILQ 273
L + + +++++ L L SL L + N L + +F + ++S N L
Sbjct: 154 LRLDDNRISTISSPSLQGLTSLKRLVLDGNL-LNNHGLGDKVFFNLVNLTELSLVRNSLT 212
Query: 274 P---NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
NL G +LRK L N + + NAF+ +L LD+SNNN+++L F L +
Sbjct: 213 AAPVNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 271
Query: 331 KHLDLSWN 338
L L N
Sbjct: 272 TQLILRNN 279
>AK027297-1|BAB55023.1| 649|Homo sapiens protein ( Homo sapiens
cDNA FLJ14391 fis, clone HEMBA1003077, weakly similar to
SLIT PROTEIN PRECURSOR. ).
Length = 649
Score = 71.7 bits (168), Expect = 9e-12
Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 23/292 (7%)
Query: 237 THLKMSNNY--RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-LNHNMVR 293
T L + NN + S NL Y+ Y N L P K + L N +R
Sbjct: 61 TTLYLQNNQINNAGIPSDLKNLLKVERIYL---YHNSLDEFPTNLPKYVKELHLQENNIR 117
Query: 294 YLESNAFANNTELEYLDLSNNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ ++ + LE L L +N+++ S+ FR L+ L LS N ++ IP +
Sbjct: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWG----L 173
Query: 352 P-SLTQLKLSRNYLSRVGH-----LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
P ++ +L+L N +S + L S+ +LD + + +G L ++ EL L
Sbjct: 174 PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLV 233
Query: 406 QNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFD 465
+N L+ P ++ L+ L L N I+ + F L +L L + N + + + FD
Sbjct: 234 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL-PQGIFD 292
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANV 517
+ +L L +N W C C + +RD+ + ++ N + L+C +P V
Sbjct: 293 DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVR----GLMCQAPEKV 340
Score = 55.2 bits (127), Expect = 8e-07
Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ R LT IP G+ T L + NN+
Sbjct: 34 VCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN------------------- 72
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L NL +E + L N D + P + LP ++K L L N +T +
Sbjct: 73 --AGIPSD-LKNLLKVERIYLYHNSLDEF----PTN--LPK-YVKELHLQENNIRT---I 119
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISSSLRS 214
L P LE L LD ++++ N +R+L L+ N L I + ++
Sbjct: 120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEE 179
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC-NILQ 273
L + + +++++ L L SL L + N L + +F + ++S N L
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNL-LNNHGLGDKVFFNLVNLTELSLVRNSLT 238
Query: 274 P---NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
NL G +LRK L N + + NAF+ +L LD+SNNN+++L F L +
Sbjct: 239 AAPVNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 297
Query: 331 KHLDLSWN 338
L L N
Sbjct: 298 TQLILRNN 305
>AF246971-1|AAF64061.1| 1059|Homo sapiens Toll-like receptor 8
protein.
Length = 1059
Score = 71.7 bits (168), Expect = 9e-12
Identities = 117/501 (23%), Positives = 214/501 (42%), Gaps = 67/501 (13%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL--- 97
D +CS R L ++P +G VT+L++S+N T ES L NL ++++ N
Sbjct: 61 DSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH 120
Query: 98 ----KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
G+ N L N+T LNL +N + L N + + +LS + +
Sbjct: 121 QNGNPGIQSNGL-NITDGAFLNL-KNLRELLLEDNQLPQIPSGLPESLTELSLIQ-NNIY 177
Query: 154 NLANQELLIRPSLETLILD-HCEINSIHGRSPLSG-----LINIRVLKLNFNPLLRIQNL 207
N+ + + +L+ L L +C N + ++ + L N+ +L L+FN L +
Sbjct: 178 NITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVSPK 237
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN-----------YRLELASSAN-N 255
+ SSLR LF+SN ++ ++ + L +LT L +S N + +S N +
Sbjct: 238 LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINID 297
Query: 256 LFS----QSLKYIDISYCNILQPN---LKGFPSLRKAILNHN-MVRYLESNAFANN-TEL 306
F+ L+Y+++S ++ + N K P L+ L N +V + S AF L
Sbjct: 298 RFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRL 357
Query: 307 EYLDLSNNNI---------ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQL 357
E LDLS N I S + L+ L + E+ L+++P+L+ +
Sbjct: 358 EILDLSFNYIKGSYPQHINISRNFSKPLSLRALHLRGYVFQELREDDFQPLMQLPNLSTI 417
Query: 358 KLSRNYLSRVGH--LRSMS-VTILDMSSCELNTIGKDSLEGL--------------QSIV 400
L N++ ++ ++ S + I+ +S ++ + KD+ + +
Sbjct: 418 NLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF 477
Query: 401 ELDLSQNLLSYIPDSISSNTLKY---LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTM 457
E D N + I Y L+L+ N I I F L + L++ N
Sbjct: 478 EFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 537
Query: 458 IWRRSFFDSNPYLERLDLSDN 478
+ + F + P+++ LDL++N
Sbjct: 538 VLSGTEFSAIPHVKYLDLTNN 558
Score = 62.5 bits (145), Expect = 5e-09
Identities = 114/446 (25%), Positives = 182/446 (40%), Gaps = 41/446 (9%)
Query: 63 QVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKG-LPDNA-LYNLTALEVLNLSRN 119
Q+ LN+S+ K + + +L LD+ N L G + A L L LE+L+LS N
Sbjct: 306 QLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN 365
Query: 120 Y----FDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
Y + +N++ N L+ L L FQ + Q L+ P+L T+ L
Sbjct: 366 YIKGSYPQHINISRN--FSKPLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINF 423
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
I I + N+ ++ L+ N RI L+ + +S S+ +
Sbjct: 424 IKQIDFKL-FQNFSNLEIIYLSEN---RISPLVKDTRQSYANSSSFQRHIRKRRSTDFEF 479
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI--LQPN-LKGFPSLRKAILNHNM- 291
H SN Y + K +D+S +I + PN + P + L+ N
Sbjct: 480 DPH---SNFYHFTRPLIKPQCAAYG-KALDLSLNSIFFIGPNQFENLPDIACLNLSANSN 535
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNE----IAVIPE-- 345
+ L F+ ++YLDL+NN + L L+ LDLS+N IA +
Sbjct: 536 AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHL 595
Query: 346 DSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDS-------LEG 395
+ + +L L LS N + + +L S S+ L S L+ + D +G
Sbjct: 596 EFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKG 655
Query: 396 LQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
L+++ LDLS N L +IP+ N +L L++N N + N RL L + G
Sbjct: 656 LKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRG 715
Query: 453 NRFTMIWRRSFFDSNPYLERLDLSDN 478
N+ + S D L L LS N
Sbjct: 716 NKLLFL-TDSLSDFTSSLRTLLLSHN 740
Score = 61.7 bits (143), Expect = 9e-09
Identities = 100/415 (24%), Positives = 187/415 (45%), Gaps = 36/415 (8%)
Query: 80 SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHL 139
+ L L L++SS L+ + N+ L+VL+L NY + +LP L
Sbjct: 300 AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP--RL 357
Query: 140 KILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN 199
+ILDLSFN + G+ + R + L L ++H L G + + + +F
Sbjct: 358 EILDLSFNYIK--GSYPQHINISRNFSKPLSL-----RALH----LRGYVFQELREDDFQ 406
Query: 200 PLLRIQNLISSSLRSLFVSNCELT---SLNHNELMFLPSLTHLKMSNNYRLELASSAN-N 255
PL+++ NL + +L F+ + + ++ E+++L + + R A+S++
Sbjct: 407 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 466
Query: 256 LFSQSLKYIDI------SYCNILQPNLKG-FPSLRKAI-LNHNMVRYLESNAFANNTELE 307
+ + D ++ + +P +K + KA+ L+ N + ++ N F N ++
Sbjct: 467 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA 526
Query: 308 YLDLSNNNIASLRYDT-FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN-YLS 365
L+LS N+ A + T F + +K+LDL+ N + +L E+ L L LS N +
Sbjct: 527 CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYF 586
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL- 424
R+ + I + ++ ++ + +++ L L+ S++L+ + S N L L
Sbjct: 587 RIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE-SKSLVELV---FSGNRLDILW 642
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
N + NR SI F L LT L + NR I +F + L L ++DNM
Sbjct: 643 NDDDNRYISI----FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM 693
Score = 60.9 bits (141), Expect = 2e-08
Identities = 112/400 (28%), Positives = 169/400 (42%), Gaps = 52/400 (13%)
Query: 104 ALYNLTALEVLNLS----RNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQE 159
A NLT L LNLS R +W P HLK+LDL FN +G +A+
Sbjct: 300 AFQNLTQLRYLNLSSTSLRKINAAWFKNMP--------HLKVLDLEFNYL--VGEIASGA 349
Query: 160 LL-IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVS 218
L + P LE L L N I G P INI NF+ L ++ L LR
Sbjct: 350 FLTMLPRLEILDLS---FNYIKGSYPQH--INI---SRNFSKPLSLRAL---HLRGYVFQ 398
Query: 219 NCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKG 278
EL + LM LP+L+ + + N+ ++ FS +L+ I +S N + P +K
Sbjct: 399 --ELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFS-NLEIIYLSE-NRISPLVK- 453
Query: 279 FPSLRKAILNHNMV-RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
R++ N + R++ +T+ E+ SN + + K LDLS
Sbjct: 454 --DTRQSYANSSSFQRHIRKR---RSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSL 508
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMS----VTILDMSSCELNTIGKDSL 393
N I I + +P + L LS N ++V S V LD+++ L+ +L
Sbjct: 509 NSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASAL 568
Query: 394 EGLQSIVELDLSQNL-------LSYIPDSISSNT-LKYLNLNYNRISSINNLTFFMLNRL 445
L + LDLS N +++ + I + T LK LNL++N I ++ + L
Sbjct: 569 TELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSL 628
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
L GNR ++W D N Y+ N+ R D S
Sbjct: 629 VELVFSGNRLDILWND---DDNRYISIFKGLKNLTRLDLS 665
Score = 60.5 bits (140), Expect = 2e-08
Identities = 87/303 (28%), Positives = 124/303 (40%), Gaps = 24/303 (7%)
Query: 90 LDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKF 149
LD+S N + + N NL + LNLS N L+ + H+K LDL+ N+
Sbjct: 504 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAI---PHVKYLDLTNNRL 560
Query: 150 QTMGNLANQELLIRPSLETLILDHC-EINSI-HGRSPLSGLINIRVLKLNFNPLLRIQ-- 205
A EL L+ H I + H + N++VL L+ N + +
Sbjct: 561 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 620
Query: 206 -NLISSSLRSLFVSNCELTSL-NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY 263
NL S SL L S L L N ++ ++ LK N RL+L S N L K+
Sbjct: 621 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLK--NLTRLDL--SLNRL-----KH 671
Query: 264 IDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
I N NL SL + +N NM+++ LE LDL N + L
Sbjct: 672 IP----NEAFLNLPA--SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL 725
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSC 383
L+ L LS N I+ +P L E+ SL L LS N L + + T +S
Sbjct: 726 SDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 785
Query: 384 ELN 386
EL+
Sbjct: 786 ELH 788
Score = 55.6 bits (128), Expect = 6e-07
Identities = 74/265 (27%), Positives = 122/265 (46%), Gaps = 21/265 (7%)
Query: 67 LNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN--YFDSW 124
L+ ++N S + ++ LD+++N+L +AL L+ LEVL+LS N YF
Sbjct: 530 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA 589
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEI----NSIH 180
+ + + T+LK+L+LS N T+ + N E SL L+ + N
Sbjct: 590 GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE---SKSLVELVFSGNRLDILWNDDD 646
Query: 181 GR--SPLSGLINIRVLKLNFNPLLRIQN----LISSSLRSLFVSNCELTSLNHNELMFLP 234
R S GL N+ L L+ N L I N + +SL L +++ L N L P
Sbjct: 647 NRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFP 706
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PN--LKGFPSLRKAILNHNM 291
L L + N L L S ++ F+ SL+ + +S+ I P+ L SL+ L+ N+
Sbjct: 707 RLELLDLRGNKLLFLTDSLSD-FTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 765
Query: 292 VRYLESNAF--ANNTELEYLDLSNN 314
++ + +A T+L L+L N
Sbjct: 766 LKTINKSALETKTTTKLSMLELHGN 790
Score = 42.3 bits (95), Expect = 0.006
Identities = 74/288 (25%), Positives = 127/288 (44%), Gaps = 21/288 (7%)
Query: 136 ATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLK 195
A + K LDLS N +G + L P + L L + + S + +++ L
Sbjct: 498 AAYGKALDLSLNSIFFIGPNQFENL---PDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 554
Query: 196 LNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMF-LPSLTH-LKMSNNY-RLELAS- 251
L N L N +S+L L S+ E+ L++N F + +TH L+ N+ L++ +
Sbjct: 555 LT-NNRLDFDN--ASALTEL--SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNL 609
Query: 252 SANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDL 311
S NN+++ + KY ++ ++++ G + + N + RY+ + F L LDL
Sbjct: 610 SHNNIYTLTDKY-NLESKSLVELVFSG--NRLDILWNDDDNRYI--SIFKGLKNLTRLDL 664
Query: 312 SNNNIASLRYDTFRGLKM-LKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHL 370
S N + + + F L L L ++ N + L + P L L L N L +
Sbjct: 665 SLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDS 724
Query: 371 RS---MSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS 415
S S+ L +S ++ + L + S+ LDLS NLL I S
Sbjct: 725 LSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 772
>AF169677-1|AAF28461.1| 649|Homo sapiens leucine-rich repeat
transmembrane protein FLRT3 protein.
Length = 649
Score = 71.7 bits (168), Expect = 9e-12
Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 23/292 (7%)
Query: 237 THLKMSNNY--RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-LNHNMVR 293
T L + NN + S NL Y+ Y N L P K + L N +R
Sbjct: 61 TTLYLQNNQINNAGIPSDLKNLLKVERIYL---YHNSLDEFPTNLPKYVKELHLQENNIR 117
Query: 294 YLESNAFANNTELEYLDLSNNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ ++ + LE L L +N+++ S+ FR L+ L LS N ++ IP +
Sbjct: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWG----L 173
Query: 352 P-SLTQLKLSRNYLSRVGH-----LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
P ++ +L+L N +S + L S+ +LD + + +G L ++ EL L
Sbjct: 174 PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLV 233
Query: 406 QNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFD 465
+N L+ P ++ L+ L L N I+ + F L +L L + N + + + FD
Sbjct: 234 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL-PQGIFD 292
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANV 517
+ +L L +N W C C + +RD+ + ++ N + L+C +P V
Sbjct: 293 DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVR----GLMCQAPEKV 340
Score = 55.2 bits (127), Expect = 8e-07
Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ R LT IP G+ T L + NN+
Sbjct: 34 VCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN------------------- 72
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L NL +E + L N D + P + LP ++K L L N +T +
Sbjct: 73 --AGIPSD-LKNLLKVERIYLYHNSLDEF----PTN--LPK-YVKELHLQENNIRT---I 119
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISSSLRS 214
L P LE L LD ++++ N +R+L L+ N L I + ++
Sbjct: 120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEE 179
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC-NILQ 273
L + + +++++ L L SL L + N L + +F + ++S N L
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNL-LNNHGLGDKVFFNLVNLTELSLVRNSLT 238
Query: 274 P---NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
NL G +LRK L N + + NAF+ +L LD+SNNN+++L F L +
Sbjct: 239 AAPVNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 297
Query: 331 KHLDLSWN 338
L L N
Sbjct: 298 TQLILRNN 305
>AF169676-1|AAF28460.1| 660|Homo sapiens leucine-rich repeat
transmembrane protein FLRT2 protein.
Length = 660
Score = 71.7 bits (168), Expect = 9e-12
Identities = 75/306 (24%), Positives = 134/306 (43%), Gaps = 17/306 (5%)
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF 279
C SL L +T L + NN ++ A L + + Y N L
Sbjct: 49 CNERSLTSVPLGIPEGVTVLYLHNN-QINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNL 107
Query: 280 P-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD--TFRGLKMLKHLDLS 336
P ++R L N ++ + A A +LE L L +N+I+++ + FR LK L LS
Sbjct: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLS 167
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI-GKDSLEG 395
N ++ +P ++ L +L++ N ++ + + ++T L+ + N + K EG
Sbjct: 168 KNHLSSVPVGLPVD---LQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEG 224
Query: 396 ----LQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
L + E + +N LS+ P + L L L N+I+ I F L +L L +
Sbjct: 225 TFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDIS 284
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLIC 511
N+ M+ + FD+ L++L +N W CDCS + + ++ ++ N + +C
Sbjct: 285 NNQLRML-TQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVR----GFMC 339
Query: 512 NSPANV 517
P V
Sbjct: 340 QGPEQV 345
Score = 63.3 bits (147), Expect = 3e-09
Identities = 77/300 (25%), Positives = 129/300 (43%), Gaps = 35/300 (11%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK--FPESLSRLHNLVNLDIS 93
+CRC D+ + C+ R LT +P G+ VT L + NN+ FP L + ++ + +
Sbjct: 39 VCRC--DRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLY 96
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
NQL P N N + VL+L N + L L+ L L N T+G
Sbjct: 97 GNQLDEFPMNLPKN---VRVLHLQENN----IQTISRAALAQLLKLEELHLDDNSISTVG 149
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + SL+ L L ++S+ P+ ++++ L+++ N + I ++ +L
Sbjct: 150 -VEDGAFREAISLKLLFLSKNHLSSV----PVGLPVDLQELRVDENRIAVISDMAFQNLT 204
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ 273
SL E ++ N L+ + S+ +L+ S N S
Sbjct: 205 SL-----ERLIVDGN-LLTNKGIAEGTFSHLTKLKEFSIVRNSLSHP------------P 246
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
P+L G L + L N + ++ AF+N +LE LD+SNN + L F L LK L
Sbjct: 247 PDLPG-THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQL 305
Score = 36.7 bits (81), Expect = 0.30
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
Query: 50 RRGLTDIPNGL-GLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYN 107
R L+ P L G + +L + +N+ P + S L L LDIS+NQL+ L N
Sbjct: 239 RNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDN 298
Query: 108 LTALEVLNLSRN 119
L+ L+ L N
Sbjct: 299 LSNLKQLTARNN 310
>AB040902-1|BAA95993.1| 662|Homo sapiens KIAA1469 protein protein.
Length = 662
Score = 71.7 bits (168), Expect = 9e-12
Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 23/292 (7%)
Query: 237 THLKMSNNY--RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-LNHNMVR 293
T L + NN + S NL Y+ Y N L P K + L N +R
Sbjct: 74 TTLYLQNNQINNAGIPSDLKNLLKVERIYL---YHNSLDEFPTNLPKYVKELHLQENNIR 130
Query: 294 YLESNAFANNTELEYLDLSNNNIA--SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEM 351
+ ++ + LE L L +N+++ S+ FR L+ L LS N ++ IP +
Sbjct: 131 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWG----L 186
Query: 352 P-SLTQLKLSRNYLSRVGH-----LRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
P ++ +L+L N +S + L S+ +LD + + +G L ++ EL L
Sbjct: 187 PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLV 246
Query: 406 QNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFD 465
+N L+ P ++ L+ L L N I+ + F L +L L + N + + + FD
Sbjct: 247 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL-PQGIFD 305
Query: 466 SNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLICNSPANV 517
+ +L L +N W C C + +RD+ + ++ N + L+C +P V
Sbjct: 306 DLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVR----GLMCQAPEKV 353
Score = 55.2 bits (127), Expect = 8e-07
Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 41/308 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSN 95
+CRC D I C+ R LT IP G+ T L + NN+
Sbjct: 47 VCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN------------------- 85
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
G+P + L NL +E + L N D + P + LP ++K L L N +T +
Sbjct: 86 --AGIPSD-LKNLLKVERIYLYHNSLDEF----PTN--LPK-YVKELHLQENNIRT---I 132
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLIN-IRVLKLNFNPLLRIQNLISSSLRS 214
L P LE L LD ++++ N +R+L L+ N L I + ++
Sbjct: 133 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEE 192
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC-NILQ 273
L + + +++++ L L SL L + N L + +F + ++S N L
Sbjct: 193 LRLDDNRISTISSPSLQGLTSLKRLVLDGNL-LNNHGLGDKVFFNLVNLTELSLVRNSLT 251
Query: 274 P---NLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
NL G +LRK L N + + NAF+ +L LD+SNNN+++L F L +
Sbjct: 252 AAPVNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 310
Query: 331 KHLDLSWN 338
L L N
Sbjct: 311 TQLILRNN 318
>AB007865-1|BAA23701.2| 706|Homo sapiens KIAA0405 protein.
Length = 706
Score = 71.7 bits (168), Expect = 9e-12
Identities = 75/306 (24%), Positives = 134/306 (43%), Gaps = 17/306 (5%)
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF 279
C SL L +T L + NN ++ A L + + Y N L
Sbjct: 95 CNERSLTSVPLGIPEGVTVLYLHNN-QINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNL 153
Query: 280 P-SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD--TFRGLKMLKHLDLS 336
P ++R L N ++ + A A +LE L L +N+I+++ + FR LK L LS
Sbjct: 154 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLS 213
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI-GKDSLEG 395
N ++ +P ++ L +L++ N ++ + + ++T L+ + N + K EG
Sbjct: 214 KNHLSSVPVGLPVD---LQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEG 270
Query: 396 ----LQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
L + E + +N LS+ P + L L L N+I+ I F L +L L +
Sbjct: 271 TFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDIS 330
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLIC 511
N+ M+ + FD+ L++L +N W CDCS + + ++ ++ N + +C
Sbjct: 331 NNQLRML-TQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVR----GFMC 385
Query: 512 NSPANV 517
P V
Sbjct: 386 QGPEQV 391
Score = 63.3 bits (147), Expect = 3e-09
Identities = 77/300 (25%), Positives = 129/300 (43%), Gaps = 35/300 (11%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTK--FPESLSRLHNLVNLDIS 93
+CRC D+ + C+ R LT +P G+ VT L + NN+ FP L + ++ + +
Sbjct: 85 VCRC--DRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLY 142
Query: 94 SNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG 153
NQL P N N + VL+L N + L L+ L L N T+G
Sbjct: 143 GNQLDEFPMNLPKN---VRVLHLQENN----IQTISRAALAQLLKLEELHLDDNSISTVG 195
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+ + SL+ L L ++S+ P+ ++++ L+++ N + I ++ +L
Sbjct: 196 -VEDGAFREAISLKLLFLSKNHLSSV----PVGLPVDLQELRVDENRIAVISDMAFQNLT 250
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ 273
SL E ++ N L+ + S+ +L+ S N S
Sbjct: 251 SL-----ERLIVDGN-LLTNKGIAEGTFSHLTKLKEFSIVRNSLSHP------------P 292
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
P+L G L + L N + ++ AF+N +LE LD+SNN + L F L LK L
Sbjct: 293 PDLPG-THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQL 351
Score = 36.7 bits (81), Expect = 0.30
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
Query: 50 RRGLTDIPNGL-GLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYN 107
R L+ P L G + +L + +N+ P + S L L LDIS+NQL+ L N
Sbjct: 285 RNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDN 344
Query: 108 LTALEVLNLSRN 119
L+ L+ L N
Sbjct: 345 LSNLKQLTARNN 356
>AF051151-1|AAC34376.1| 858|Homo sapiens Toll/interleukin-1
receptor-like protein 3 protein.
Length = 858
Score = 71.3 bits (167), Expect = 1e-11
Identities = 111/437 (25%), Positives = 202/437 (46%), Gaps = 47/437 (10%)
Query: 64 VTKLNISNNEFTKF--PESLSRLHNLVNLDISSNQLKGLPDNALYNLTA--LEVLNLSRN 119
+T+L++S N+ S +L++L ++D SSNQ+ + ++ L L L +L+ N
Sbjct: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAAN 206
Query: 120 YFDSWLNLNPNDVLLPATH--LKILDLSFNKFQT--MGNLANQELLIRPSLETLILDHCE 175
S ++++ + P + L+I+D+S N + GN +N + + +LIL H
Sbjct: 207 SLYSRVSVDWGKCMNPFRNMVLEIVDVSGNGWTVDITGNFSNA--ISKSQAFSLILAH-- 262
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPS 235
H G NI+ N L SS+R L +S+ + SLN L
Sbjct: 263 ----HIMGAGFGFHNIKDPDQN-----TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKD 313
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNIL----QPNLKGFPSLRKAILNHNM 291
L L ++ N ++A A +L+ +++SY N+L N G P + L N
Sbjct: 314 LKVLNLAYNKINKIADEAFYGLD-NLQVLNLSY-NLLGELCSSNFYGLPKVAYIDLQKNH 371
Query: 292 VRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL-E 350
+ ++ F +L+ LDL +N + ++ + + + + LS N++ +P+ +L
Sbjct: 372 IAIIQDQTFKFLEKLQTLDLRDNALTTIHF-----IPSIPDIFLSGNKLVTLPKINLTAN 426
Query: 351 MPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKD--SLEGL---QSIVE 401
+ L++ +L +L RV HL+ + + SSC + + SLE L +++++
Sbjct: 427 LIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQ 486
Query: 402 LDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRR 461
L L + + +S L+ L LN+N ++S+ F L L LS+ NR T++
Sbjct: 487 LAWETELCWDVFEGLSH--LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL--- 541
Query: 462 SFFDSNPYLERLDLSDN 478
S D LE LD+S N
Sbjct: 542 SHNDLPANLEILDISRN 558
Score = 66.9 bits (156), Expect = 2e-10
Identities = 54/216 (25%), Positives = 105/216 (48%), Gaps = 7/216 (3%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
S+R L+H V L S F +L+ L+L+ N I + + F GL L+ L+LS+N +
Sbjct: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILD-MSSCELNTIGKDSLEGLQSI 399
+ + +P + + L +N+++ + + + L+ + + +L ++ + SI
Sbjct: 349 GELCSSNFYGLPKVAYIDLQKNHIAII---QDQTFKFLEKLQTLDLRDNALTTIHFIPSI 405
Query: 400 VELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFM-LNRLTSLSVVGNRFTMI 458
++ LS N L +P + T ++L+ NR+ +++ L F + + L L + NRF+
Sbjct: 406 PDIFLSGNKLVTLPKI--NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSC 463
Query: 459 WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
NP LE+L L +NM + E D ++
Sbjct: 464 SGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499
Score = 46.4 bits (105), Expect = 4e-04
Identities = 69/267 (25%), Positives = 115/267 (43%), Gaps = 23/267 (8%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLN----PN--DVLLPAT 137
L +L L+++ N++ + D A Y L L+VLNLS N + N P + L
Sbjct: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELCSSNFYGLPKVAYIDLQKN 370
Query: 138 HLKIL-DLSF---NKFQTMGNLANQELLIR--PSLETLILDHCEINSIHGRSPLSGLINI 191
H+ I+ D +F K QT+ N I PS+ + L ++ ++ + + LI++
Sbjct: 371 HIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHL 430
Query: 192 RVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNEL-MFLPSLTHLKMSNN-----Y 245
+L +L L L+ L ++ +S + ++ PSL L + N +
Sbjct: 431 SENRLENLDILYFL-LRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAW 489
Query: 246 RLELASSA-NNLFSQSLKYIDISYCNILQPNL-KGFPSLRKAILNHNMVRYLESNAFANN 303
EL L + Y++ +Y N L P + +LR LN N + L N N
Sbjct: 490 ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPAN 549
Query: 304 TELEYLDLSNNNIASLRYDTFRGLKML 330
LE LD+S N + + D F L +L
Sbjct: 550 --LEILDISRNQLLAPNPDVFVSLSVL 574
Score = 39.5 bits (88), Expect = 0.043
Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 10/111 (9%)
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI--AVIPEDSLLEMP 352
++ AF N L LDL ++ I L D F+GL L L L + + AV+ + +
Sbjct: 86 IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLK 145
Query: 353 SLTQLKLSRNYLSRV------GHLRSMSVTILDMSSCELNTIGKDSLEGLQ 397
+LT+L LS+N + + G L S+ +D SS ++ + + LE LQ
Sbjct: 146 ALTRLDLSKNQIRSLYLHPSFGKLNSLK--SIDFSSNQIFLVCEHELEPLQ 194
Score = 39.5 bits (88), Expect = 0.043
Identities = 63/218 (28%), Positives = 99/218 (45%), Gaps = 30/218 (13%)
Query: 86 NLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLS 145
++ ++ +S N+L LP NLTA +++LS N + NL+ LL HL+IL L+
Sbjct: 404 SIPDIFLSGNKLVTLPK---INLTA-NLIHLSENRLE---NLDILYFLLRVPHLQILILN 456
Query: 146 FNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQ 205
N+F + +Q PSLE L L G + L + F L
Sbjct: 457 QNRFSSCSG--DQTPSENPSLEQLFL---------GENMLQLAWETELCWDVFEGL---- 501
Query: 206 NLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYID 265
S L+ L++++ L SL L +L L +++N RL + S +N +L+ +D
Sbjct: 502 ----SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN-RLTVLS--HNDLPANLEILD 554
Query: 266 ISYCNILQPNLKGFPSLRKAILNHN-MVRYLESNAFAN 302
IS +L PN F SL + HN + E + F N
Sbjct: 555 ISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFIN 592
Score = 33.9 bits (74), Expect = 2.1
Identities = 37/141 (26%), Positives = 64/141 (45%), Gaps = 9/141 (6%)
Query: 327 LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY----LSRVGHLRSMSVTILDMSS 382
L + L LS+N I + S + L L+L Y + + ++ ILD+ S
Sbjct: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGS 104
Query: 383 CELNTIGKDSLEGLQSIVELDLSQNLLS--YIPDSISSN--TLKYLNLNYNRISSIN-NL 437
++ + D+ +GL + EL L LS + D N L L+L+ N+I S+ +
Sbjct: 105 SKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHP 164
Query: 438 TFFMLNRLTSLSVVGNRFTMI 458
+F LN L S+ N+ ++
Sbjct: 165 SFGKLNSLKSIDFSSNQIFLV 185
>U93091-1|AAC80227.1| 839|Homo sapiens Toll protein homolog
protein.
Length = 839
Score = 70.9 bits (166), Expect = 2e-11
Identities = 102/404 (25%), Positives = 185/404 (45%), Gaps = 49/404 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNN--EFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
++ + L + P G + +LN+++N + K PE S L NL +LD+SSN+++ +
Sbjct: 134 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCT 193
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT--HLKILDLSF-NKFQTMGNLANQ-E 159
L L + +LNLS + L+LNP + + P +++ L+ N F ++ + +
Sbjct: 194 DLRVLHQMPLLNLSLD-----LSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQ 248
Query: 160 LLIRPSLETLILDHC--EIN-SIHGRSPLSGLINIRV-------LKLNFNPLLRIQNLIS 209
L + L+L E N +S L GL N+ + L + ++ + N ++
Sbjct: 249 GLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLT 308
Query: 210 S----SLRSLFVSNCELTSLN----HNELMFLP--SLTHLKMSNNYRLELASS-ANNLFS 258
+ SL S+ + + S N H EL+ LK+ + RL S+ N FS
Sbjct: 309 NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFS 368
Query: 259 Q----SLKYIDIS-----YCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
+ SL+++D+S + + G SL+ L+ N V + SN F +LE+L
Sbjct: 369 EVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHL 427
Query: 310 DLSNNNIASL-RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLS-----RNY 363
D ++N+ + + F L+ L +LD+S V + SL LK++ N+
Sbjct: 428 DFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENF 487
Query: 364 LSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
L + ++T LD+S C+L + + L S+ L++S N
Sbjct: 488 LPDI-FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 530
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 35 FLCRCNLDKTDIDCS--RRGLTDIPNGLG-LQVTKLNISNNEFTKFPESLSRLHNLVNLD 91
FL NL DI + R I NGL L+V K+ ++ + P+ + L NL LD
Sbjct: 443 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD 502
Query: 92 ISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQT 151
+S QL+ L A +L++L+VLN+S N F S L+ P L L++LD S N T
Sbjct: 503 LSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFS-LDTFPYKCL---NSLQVLDYSLNHIMT 558
Score = 48.4 bits (110), Expect = 9e-05
Identities = 96/406 (23%), Positives = 172/406 (42%), Gaps = 36/406 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
LS L LV ++ + L+ P + +L L+ LN++ N S+ + T+L+
Sbjct: 125 LSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLIQSF---KLPEYFSNLTNLE 178
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
LDLS NK Q++ + +L + L L LD +N ++ P IR+ KL
Sbjct: 179 HLDLSSNKIQSI-YCTDLRVLHQMPLLNLSLD-LSLNPMNFIQP-GAFKEIRLHKLTLRN 235
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
N++ + ++ L L + L+ L + N S+ L + +
Sbjct: 236 NFDSLNVMKTCIQGL-------AGLEVHRLV----LGEFRNEGNLEKFDKSALEGLCNLT 284
Query: 261 LKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA--FANNTELEYLDLSNNNIAS 318
++ ++Y + ++ + + + ++V F+ N ++L+L N
Sbjct: 285 IEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFG- 343
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-----HLRSM 373
++ T + LK LK L + N+ S +++PSL L LSRN LS G +
Sbjct: 344 -QFPTLK-LKSLKRLTFTSNKGG--NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTT 399
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS---ISSNTLKYLNLNYNR 430
S+ LD+S + T+ + L GL+ + LD + L + + +S L YL++++
Sbjct: 400 SLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 458
Query: 431 ISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
N F L+ L L + GN F + F L LDLS
Sbjct: 459 TRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLS 504
Score = 47.2 bits (107), Expect = 2e-04
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAI---LNHN 290
SL +L +S N + ++S N L + L+++D + N+ Q + F SLR I ++H
Sbjct: 400 SLKYLDLSFNGVITMSS--NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHT 457
Query: 291 MVRYLESNAFANNTELEYLDLSNNNIA-SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
R + F + LE L ++ N+ + D F L+ L LDLS ++ + +
Sbjct: 458 HTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 517
Query: 350 EMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGL-QSIVELDLS 405
+ SL L +S N L + S+ +LD S + T K L+ S+ L+L+
Sbjct: 518 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 577
Query: 406 QN 407
QN
Sbjct: 578 QN 579
Score = 46.8 bits (106), Expect = 3e-04
Identities = 77/281 (27%), Positives = 124/281 (44%), Gaps = 19/281 (6%)
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL-NPNDVLLPATHLKILD-LSFNKFQTM 152
N L + +L ++T V + S N+ L L N P LK L L+F
Sbjct: 305 NCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NK 362
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQN--LI 208
G A E+ + PSLE L L + S G S G +++ L L+FN ++ + + L
Sbjct: 363 GGNAFSEVDL-PSLEFLDLSRNGL-SFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG 420
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLPSLTHLKMSNNY-RLELASSANNLFS-QSLKYID 265
L L + L ++ + + L +L +L +S+ + R+ N L S + LK
Sbjct: 421 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 480
Query: 266 ISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD 322
S+ P++ F LR L+ + L AF + + L+ L++S+NN SL
Sbjct: 481 NSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 538
Query: 323 TFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRN 362
++ L L+ LD S N I + L P SL L L++N
Sbjct: 539 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 579
Score = 44.0 bits (99), Expect = 0.002
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 74 FTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVL 133
F K P++L + NLD+S N L+ L + ++ L+VL+LSR + +
Sbjct: 45 FYKIPDNLP--FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR----CEIQTIEDGAY 98
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
+HL L L+ N Q++ A L SL+ L+ + S+ P+ L ++
Sbjct: 99 QSLSHLSTLILTGNPIQSLALGAFSGL---SSLQKLVAVETNLASLE-NFPIGHLKTLKE 154
Query: 194 LKLNFNPL--LRIQNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL 249
L + N + ++ S ++L L +S+ ++ S+ +L L + L +S L+L
Sbjct: 155 LNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS----LDL 210
Query: 250 ASSANNLFSQSLKYIDISYCNI-LQPNLKGFPSLRKAI--LNHNMVRYLESNAFANNTEL 306
+ + N F Q + +I + L+ N ++ I L V L F N L
Sbjct: 211 SLNPMN-FIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNL 269
Query: 307 EYLDLSN-NNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
E D S + +L + FR + +LD + + S + S+T ++ +++
Sbjct: 270 EKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVT-IERVKDFSY 328
Query: 366 RVG--HLRSMSVTILDMSSCELNTIGK---DSLEG--------LQSIVELDLSQNLLSY- 411
G HL ++ + +L ++ + S +G L S+ LDLS+N LS+
Sbjct: 329 NFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK 388
Query: 412 ---IPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNP 468
+ +LKYL+L++N + ++++ F L +L L + + S F S
Sbjct: 389 GCCSQSDFGTTSLKYLDLSFNGVITMSS-NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLR 447
Query: 469 YLERLDLS 476
L LD+S
Sbjct: 448 NLIYLDIS 455
>U88880-1|AAC34135.1| 799|Homo sapiens Toll-like receptor 4
protein.
Length = 799
Score = 70.9 bits (166), Expect = 2e-11
Identities = 102/404 (25%), Positives = 185/404 (45%), Gaps = 49/404 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNN--EFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
++ + L + P G + +LN+++N + K PE S L NL +LD+SSN+++ +
Sbjct: 94 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCT 153
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT--HLKILDLSF-NKFQTMGNLANQ-E 159
L L + +LNLS + L+LNP + + P +++ L+ N F ++ + +
Sbjct: 154 DLRVLHQMPLLNLSLD-----LSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQ 208
Query: 160 LLIRPSLETLILDHC--EIN-SIHGRSPLSGLINIRV-------LKLNFNPLLRIQNLIS 209
L + L+L E N +S L GL N+ + L + ++ + N ++
Sbjct: 209 GLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLT 268
Query: 210 S----SLRSLFVSNCELTSLN----HNELMFLP--SLTHLKMSNNYRLELASS-ANNLFS 258
+ SL S+ + + S N H EL+ LK+ + RL S+ N FS
Sbjct: 269 NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFS 328
Query: 259 Q----SLKYIDIS-----YCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
+ SL+++D+S + + G SL+ L+ N V + SN F +LE+L
Sbjct: 329 EVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHL 387
Query: 310 DLSNNNIASL-RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLS-----RNY 363
D ++N+ + + F L+ L +LD+S V + SL LK++ N+
Sbjct: 388 DFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENF 447
Query: 364 LSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
L + ++T LD+S C+L + + L S+ L++S N
Sbjct: 448 LPDI-FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 490
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 35 FLCRCNLDKTDIDCS--RRGLTDIPNGLG-LQVTKLNISNNEFTKFPESLSRLHNLVNLD 91
FL NL DI + R I NGL L+V K+ ++ + P+ + L NL LD
Sbjct: 403 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD 462
Query: 92 ISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQT 151
+S QL+ L A +L++L+VLN+S N F S L+ P L L++LD S N T
Sbjct: 463 LSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFS-LDTFPYKCL---NSLQVLDYSLNHIMT 518
Score = 48.4 bits (110), Expect = 9e-05
Identities = 96/406 (23%), Positives = 172/406 (42%), Gaps = 36/406 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
LS L LV ++ + L+ P + +L L+ LN++ N S+ + T+L+
Sbjct: 85 LSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLIQSF---KLPEYFSNLTNLE 138
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
LDLS NK Q++ + +L + L L LD +N ++ P IR+ KL
Sbjct: 139 HLDLSSNKIQSI-YCTDLRVLHQMPLLNLSLD-LSLNPMNFIQP-GAFKEIRLHKLTLRN 195
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
N++ + ++ L L + L+ L + N S+ L + +
Sbjct: 196 NFDSLNVMKTCIQGL-------AGLEVHRLV----LGEFRNEGNLEKFDKSALEGLCNLT 244
Query: 261 LKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA--FANNTELEYLDLSNNNIAS 318
++ ++Y + ++ + + + ++V F+ N ++L+L N
Sbjct: 245 IEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFG- 303
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-----HLRSM 373
++ T + LK LK L + N+ S +++PSL L LSRN LS G +
Sbjct: 304 -QFPTLK-LKSLKRLTFTSNKGG--NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTT 359
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS---ISSNTLKYLNLNYNR 430
S+ LD+S + T+ + L GL+ + LD + L + + +S L YL++++
Sbjct: 360 SLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 418
Query: 431 ISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
N F L+ L L + GN F + F L LDLS
Sbjct: 419 TRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLS 464
Score = 47.2 bits (107), Expect = 2e-04
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAI---LNHN 290
SL +L +S N + ++S N L + L+++D + N+ Q + F SLR I ++H
Sbjct: 360 SLKYLDLSFNGVITMSS--NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHT 417
Query: 291 MVRYLESNAFANNTELEYLDLSNNNIA-SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
R + F + LE L ++ N+ + D F L+ L LDLS ++ + +
Sbjct: 418 HTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 477
Query: 350 EMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGL-QSIVELDLS 405
+ SL L +S N L + S+ +LD S + T K L+ S+ L+L+
Sbjct: 478 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 537
Query: 406 QN 407
QN
Sbjct: 538 QN 539
Score = 46.8 bits (106), Expect = 3e-04
Identities = 77/281 (27%), Positives = 124/281 (44%), Gaps = 19/281 (6%)
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL-NPNDVLLPATHLKILD-LSFNKFQTM 152
N L + +L ++T V + S N+ L L N P LK L L+F
Sbjct: 265 NCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NK 322
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQN--LI 208
G A E+ + PSLE L L + S G S G +++ L L+FN ++ + + L
Sbjct: 323 GGNAFSEVDL-PSLEFLDLSRNGL-SFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG 380
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLPSLTHLKMSNNY-RLELASSANNLFS-QSLKYID 265
L L + L ++ + + L +L +L +S+ + R+ N L S + LK
Sbjct: 381 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 440
Query: 266 ISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD 322
S+ P++ F LR L+ + L AF + + L+ L++S+NN SL
Sbjct: 441 NSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 498
Query: 323 TFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRN 362
++ L L+ LD S N I + L P SL L L++N
Sbjct: 499 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 539
Score = 44.0 bits (99), Expect = 0.002
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 74 FTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVL 133
F K P++L + NLD+S N L+ L + ++ L+VL+LSR + +
Sbjct: 5 FYKIPDNLP--FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR----CEIQTIEDGAY 58
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
+HL L L+ N Q++ A L SL+ L+ + S+ P+ L ++
Sbjct: 59 QSLSHLSTLILTGNPIQSLALGAFSGL---SSLQKLVAVETNLASLE-NFPIGHLKTLKE 114
Query: 194 LKLNFNPL--LRIQNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL 249
L + N + ++ S ++L L +S+ ++ S+ +L L + L +S L+L
Sbjct: 115 LNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS----LDL 170
Query: 250 ASSANNLFSQSLKYIDISYCNI-LQPNLKGFPSLRKAI--LNHNMVRYLESNAFANNTEL 306
+ + N F Q + +I + L+ N ++ I L V L F N L
Sbjct: 171 SLNPMN-FIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNL 229
Query: 307 EYLDLSN-NNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
E D S + +L + FR + +LD + + S + S+T ++ +++
Sbjct: 230 EKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVT-IERVKDFSY 288
Query: 366 RVG--HLRSMSVTILDMSSCELNTIGK---DSLEG--------LQSIVELDLSQNLLSY- 411
G HL ++ + +L ++ + S +G L S+ LDLS+N LS+
Sbjct: 289 NFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK 348
Query: 412 ---IPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNP 468
+ +LKYL+L++N + ++++ F L +L L + + S F S
Sbjct: 349 GCCSQSDFGTTSLKYLDLSFNGVITMSS-NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLR 407
Query: 469 YLERLDLS 476
L LD+S
Sbjct: 408 NLIYLDIS 415
>BC117422-1|AAI17423.1| 839|Homo sapiens toll-like receptor 4
protein.
Length = 839
Score = 70.9 bits (166), Expect = 2e-11
Identities = 102/404 (25%), Positives = 185/404 (45%), Gaps = 49/404 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNN--EFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
++ + L + P G + +LN+++N + K PE S L NL +LD+SSN+++ +
Sbjct: 134 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCT 193
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT--HLKILDLSF-NKFQTMGNLANQ-E 159
L L + +LNLS + L+LNP + + P +++ L+ N F ++ + +
Sbjct: 194 DLRVLHQMPLLNLSLD-----LSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQ 248
Query: 160 LLIRPSLETLILDHC--EIN-SIHGRSPLSGLINIRV-------LKLNFNPLLRIQNLIS 209
L + L+L E N +S L GL N+ + L + ++ + N ++
Sbjct: 249 GLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLT 308
Query: 210 S----SLRSLFVSNCELTSLN----HNELMFLP--SLTHLKMSNNYRLELASS-ANNLFS 258
+ SL S+ + + S N H EL+ LK+ + RL S+ N FS
Sbjct: 309 NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFS 368
Query: 259 Q----SLKYIDIS-----YCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
+ SL+++D+S + + G SL+ L+ N V + SN F +LE+L
Sbjct: 369 EVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHL 427
Query: 310 DLSNNNIASL-RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLS-----RNY 363
D ++N+ + + F L+ L +LD+S V + SL LK++ N+
Sbjct: 428 DFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENF 487
Query: 364 LSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
L + ++T LD+S C+L + + L S+ L++S N
Sbjct: 488 LPDI-FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 530
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 35 FLCRCNLDKTDIDCS--RRGLTDIPNGLG-LQVTKLNISNNEFTKFPESLSRLHNLVNLD 91
FL NL DI + R I NGL L+V K+ ++ + P+ + L NL LD
Sbjct: 443 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD 502
Query: 92 ISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQT 151
+S QL+ L A +L++L+VLN+S N F S L+ P L L++LD S N T
Sbjct: 503 LSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFS-LDTFPYKCL---NSLQVLDYSLNHIMT 558
Score = 48.4 bits (110), Expect = 9e-05
Identities = 96/406 (23%), Positives = 172/406 (42%), Gaps = 36/406 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
LS L LV ++ + L+ P + +L L+ LN++ N S+ + T+L+
Sbjct: 125 LSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLIQSF---KLPEYFSNLTNLE 178
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
LDLS NK Q++ + +L + L L LD +N ++ P IR+ KL
Sbjct: 179 HLDLSSNKIQSI-YCTDLRVLHQMPLLNLSLD-LSLNPMNFIQP-GAFKEIRLHKLTLRN 235
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
N++ + ++ L L + L+ L + N S+ L + +
Sbjct: 236 NFDSLNVMKTCIQGL-------AGLEVHRLV----LGEFRNEGNLEKFDKSALEGLCNLT 284
Query: 261 LKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA--FANNTELEYLDLSNNNIAS 318
++ ++Y + ++ + + + ++V F+ N ++L+L N
Sbjct: 285 IEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFG- 343
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-----HLRSM 373
++ T + LK LK L + N+ S +++PSL L LSRN LS G +
Sbjct: 344 -QFPTLK-LKSLKRLTFTSNKGG--NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTT 399
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS---ISSNTLKYLNLNYNR 430
S+ LD+S + T+ + L GL+ + LD + L + + +S L YL++++
Sbjct: 400 SLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 458
Query: 431 ISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
N F L+ L L + GN F + F L LDLS
Sbjct: 459 TRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLS 504
Score = 47.2 bits (107), Expect = 2e-04
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAI---LNHN 290
SL +L +S N + ++S N L + L+++D + N+ Q + F SLR I ++H
Sbjct: 400 SLKYLDLSFNGVITMSS--NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHT 457
Query: 291 MVRYLESNAFANNTELEYLDLSNNNIA-SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
R + F + LE L ++ N+ + D F L+ L LDLS ++ + +
Sbjct: 458 HTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 517
Query: 350 EMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGL-QSIVELDLS 405
+ SL L +S N L + S+ +LD S + T K L+ S+ L+L+
Sbjct: 518 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 577
Query: 406 QN 407
QN
Sbjct: 578 QN 579
Score = 46.8 bits (106), Expect = 3e-04
Identities = 77/281 (27%), Positives = 124/281 (44%), Gaps = 19/281 (6%)
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL-NPNDVLLPATHLKILD-LSFNKFQTM 152
N L + +L ++T V + S N+ L L N P LK L L+F
Sbjct: 305 NCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NK 362
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQN--LI 208
G A E+ + PSLE L L + S G S G +++ L L+FN ++ + + L
Sbjct: 363 GGNAFSEVDL-PSLEFLDLSRNGL-SFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG 420
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLPSLTHLKMSNNY-RLELASSANNLFS-QSLKYID 265
L L + L ++ + + L +L +L +S+ + R+ N L S + LK
Sbjct: 421 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 480
Query: 266 ISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD 322
S+ P++ F LR L+ + L AF + + L+ L++S+NN SL
Sbjct: 481 NSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 538
Query: 323 TFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRN 362
++ L L+ LD S N I + L P SL L L++N
Sbjct: 539 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 579
Score = 44.0 bits (99), Expect = 0.002
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 74 FTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVL 133
F K P++L + NLD+S N L+ L + ++ L+VL+LSR + +
Sbjct: 45 FYKIPDNLP--FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR----CEIQTIEDGAY 98
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
+HL L L+ N Q++ A L SL+ L+ + S+ P+ L ++
Sbjct: 99 QSLSHLSTLILTGNPIQSLALGAFSGL---SSLQKLVAVETNLASLE-NFPIGHLKTLKE 154
Query: 194 LKLNFNPL--LRIQNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL 249
L + N + ++ S ++L L +S+ ++ S+ +L L + L +S L+L
Sbjct: 155 LNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS----LDL 210
Query: 250 ASSANNLFSQSLKYIDISYCNI-LQPNLKGFPSLRKAI--LNHNMVRYLESNAFANNTEL 306
+ + N F Q + +I + L+ N ++ I L V L F N L
Sbjct: 211 SLNPMN-FIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNL 269
Query: 307 EYLDLSN-NNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
E D S + +L + FR + +LD + + S + S+T ++ +++
Sbjct: 270 EKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVT-IERVKDFSY 328
Query: 366 RVG--HLRSMSVTILDMSSCELNTIGK---DSLEG--------LQSIVELDLSQNLLSY- 411
G HL ++ + +L ++ + S +G L S+ LDLS+N LS+
Sbjct: 329 NFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK 388
Query: 412 ---IPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNP 468
+ +LKYL+L++N + ++++ F L +L L + + S F S
Sbjct: 389 GCCSQSDFGTTSLKYLDLSFNGVITMSS-NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLR 447
Query: 469 YLERLDLS 476
L LD+S
Sbjct: 448 NLIYLDIS 455
>BC105958-1|AAI05959.1| 677|Homo sapiens ECM2 protein protein.
Length = 677
Score = 70.9 bits (166), Expect = 2e-11
Identities = 92/343 (26%), Positives = 147/343 (42%), Gaps = 30/343 (8%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-ESLSRLHNLVNLDISSNQL 97
C+L I C LT IP Q+T L ++ N P E+ + L NL LD+S N +
Sbjct: 298 CSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNI 357
Query: 98 --KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMG-- 153
G+ A L L N+ N NL LP+T L+ L ++ N Q +
Sbjct: 358 TSSGIGPKAFKLLKKLMRSNMDGN------NLIQIPSQLPST-LEELKVNENNLQAIDEE 410
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
+L++ L+ LE L +N + PL L +R+ K N I + S+
Sbjct: 411 SLSDLNQLVTLELEGNNLSEANVNPL-AFKPLKSLAYLRLGK---NKFRIIPQGLPGSIE 466
Query: 214 SLFVSNCELTSL-----NHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISY 268
L++ N ++ + NH + + L + K+ N LA + ++L+ ID+SY
Sbjct: 467 ELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAW----INQENLESIDLSY 522
Query: 269 CNILQPNLKGFPSLRKAILNHNMVRYLESNAFAN-NTELEYLDLSNNNIASLRYD--TFR 325
+ SL +L N + + F + LEYL LS N +A D +F
Sbjct: 523 NKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFY 582
Query: 326 G-LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
G L+ L L N++ IP + EM +L L+L+ N + +
Sbjct: 583 GAYHSLRELFLDHNDLKSIP-PGIQEMKALHFLRLNNNKIRNI 624
Score = 45.6 bits (103), Expect = 7e-04
Identities = 32/108 (29%), Positives = 55/108 (50%), Gaps = 2/108 (1%)
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI--AVIPEDSLLEMPSLTQLKLSRN 362
++ L+L+ N+IAS+ + F GL L+ LDLS N I + I + + L + + N
Sbjct: 322 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRSNMDGN 381
Query: 363 YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLS 410
L ++ ++ L ++ L I ++SL L +V L+L N LS
Sbjct: 382 NLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 429
Score = 44.4 bits (100), Expect = 0.002
Identities = 34/124 (27%), Positives = 63/124 (50%), Gaps = 20/124 (16%)
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDS 392
L+L+ N IA IP+++ +P+L +L LS+N ++ G IG +
Sbjct: 326 LELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSG-------------------IGPKA 366
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
+ L+ ++ ++ N L IP + S TL+ L +N N + +I+ + LN+L +L + G
Sbjct: 367 FKLLKKLMRSNMDGNNLIQIPSQLPS-TLEELKVNENNLQAIDEESLSDLNQLVTLELEG 425
Query: 453 NRFT 456
N +
Sbjct: 426 NNLS 429
>AY358884-1|AAQ89243.1| 1523|Homo sapiens SLIT3 protein.
Length = 1523
Score = 70.9 bits (166), Expect = 2e-11
Identities = 111/484 (22%), Positives = 195/484 (40%), Gaps = 60/484 (12%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQ 96
+C +DC GL +P G+ +L++ N T+ + + L NL L + NQ
Sbjct: 37 KCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQ 96
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ + A +L LE L L++N L + P + L LDLS N+ Q + A
Sbjct: 97 VSVIERGAFQDLKQLERLRLNKNK----LQVLPELLFQSTPKLTRLDLSENQIQGIPRKA 152
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
+ + ++ L LD+ I+ I L ++ +L LN N + RI L++S
Sbjct: 153 FRGI---TDVKNLQLDNNHISCIED-GAFRALRDLEILTLNNNNISRI--LVTSFNHMPK 206
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ L S NH L HL +++ + + F+ + + + N+
Sbjct: 207 IRTLRLHS-NH-----LYCDCHLAWLSDWLRQRRTVGQ--FTLCMAPVHLRGFNVADVQK 258
Query: 277 KGF----PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
K + P N N + +NN +D + + + G+ ++
Sbjct: 259 KEYVCPAPHSEPPSCNANSISCPSPCTCSNN----IVDCRGKGLMEIPANLPEGIVEIR- 313
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDS 392
L N I IP + + L ++ +S+N +S I D+
Sbjct: 314 --LEQNSIKAIPAGAFTQYKKLKRIDISKNQIS---------------------DIAPDA 350
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
+GL+S+ L L N ++ I + +L+ L LN N+I+ + TF L L LS+
Sbjct: 351 FQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSL 410
Query: 451 VGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLI 510
N+ I + F ++ L L+ N + CDC + + D+ L+ N E S
Sbjct: 411 YDNKLQTI-SKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADY-----LQDNPIETS-GAR 463
Query: 511 CNSP 514
C+SP
Sbjct: 464 CSSP 467
Score = 57.2 bits (132), Expect = 2e-07
Identities = 28/82 (34%), Positives = 44/82 (53%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQL 97
+C +T + CS +GL +P G+ VT+L + N T P LS L +L +D+S+N +
Sbjct: 728 QCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSI 787
Query: 98 KGLPDNALYNLTALEVLNLSRN 119
L + N++ L L LS N
Sbjct: 788 SMLTNYTFSNMSHLSTLILSYN 809
Score = 54.0 bits (124), Expect = 2e-06
Identities = 73/319 (22%), Positives = 137/319 (42%), Gaps = 20/319 (6%)
Query: 66 KLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
K+N+SNN+ + E + ++ L ++ NQL+ + L+ L+ L L N
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNL---- 616
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD---HCEI----N 177
++ ND + +++L L N+ T+ A L+ ++ L +C +
Sbjct: 617 ISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGK 676
Query: 178 SIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR--SLFVSNCELTSLNHNELMFLPS 235
+ R +SG N R K F + IQ++ S+C+L+ + + +
Sbjct: 677 WLRKRRIVSG--NPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMET 734
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYL 295
+ ++ SN L ++ Y++ ++ + L L L++N + L
Sbjct: 735 V--VRCSNKGLRALPRGMPKDVTEL--YLEGNHLTAVPRELSALRHLTLIDLSNNSISML 790
Query: 296 ESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLT 355
+ F+N + L L LS N + + F GL+ L+ L L N+I+ +PE S ++ SL+
Sbjct: 791 TNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLS 850
Query: 356 QLKLSRNYLSRVGHLRSMS 374
L L N L LR +S
Sbjct: 851 HLALGTNPLHCDCSLRWLS 869
Score = 45.6 bits (103), Expect = 7e-04
Identities = 24/88 (27%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES--LSRLHNLVNLDISSN 95
+C + T +DCS + L IP+ L VT L +++NE + + +L NL +++S+N
Sbjct: 508 KCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNN 567
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDS 123
++K + + A +++ L L+ N ++
Sbjct: 568 KIKEVREGAFDGAASVQELMLTGNQLET 595
Score = 45.6 bits (103), Expect = 7e-04
Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 375 VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRIS 432
VT L + L + ++ L L+ + +DLS N +S + + SN L L L+YNR+
Sbjct: 754 VTELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLR 812
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
I F L L L++ GN + + SF D L L L N CDCS
Sbjct: 813 CIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTS-LSHLALGTNPLHCDCS 864
>AL160272-2|CAH72619.1| 799|Homo sapiens toll-like receptor 4
protein.
Length = 799
Score = 70.9 bits (166), Expect = 2e-11
Identities = 102/404 (25%), Positives = 185/404 (45%), Gaps = 49/404 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNN--EFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
++ + L + P G + +LN+++N + K PE S L NL +LD+SSN+++ +
Sbjct: 94 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCT 153
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT--HLKILDLSF-NKFQTMGNLANQ-E 159
L L + +LNLS + L+LNP + + P +++ L+ N F ++ + +
Sbjct: 154 DLRVLHQMPLLNLSLD-----LSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQ 208
Query: 160 LLIRPSLETLILDHC--EIN-SIHGRSPLSGLINIRV-------LKLNFNPLLRIQNLIS 209
L + L+L E N +S L GL N+ + L + ++ + N ++
Sbjct: 209 GLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLT 268
Query: 210 S----SLRSLFVSNCELTSLN----HNELMFLP--SLTHLKMSNNYRLELASS-ANNLFS 258
+ SL S+ + + S N H EL+ LK+ + RL S+ N FS
Sbjct: 269 NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFS 328
Query: 259 Q----SLKYIDIS-----YCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
+ SL+++D+S + + G SL+ L+ N V + SN F +LE+L
Sbjct: 329 EVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHL 387
Query: 310 DLSNNNIASL-RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLS-----RNY 363
D ++N+ + + F L+ L +LD+S V + SL LK++ N+
Sbjct: 388 DFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENF 447
Query: 364 LSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
L + ++T LD+S C+L + + L S+ L++S N
Sbjct: 448 LPDI-FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 490
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 35 FLCRCNLDKTDIDCS--RRGLTDIPNGLG-LQVTKLNISNNEFTKFPESLSRLHNLVNLD 91
FL NL DI + R I NGL L+V K+ ++ + P+ + L NL LD
Sbjct: 403 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD 462
Query: 92 ISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQT 151
+S QL+ L A +L++L+VLN+S N F S L+ P L L++LD S N T
Sbjct: 463 LSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFS-LDTFPYKCL---NSLQVLDYSLNHIMT 518
Score = 48.4 bits (110), Expect = 9e-05
Identities = 96/406 (23%), Positives = 172/406 (42%), Gaps = 36/406 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
LS L LV ++ + L+ P + +L L+ LN++ N S+ + T+L+
Sbjct: 85 LSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLIQSF---KLPEYFSNLTNLE 138
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
LDLS NK Q++ + +L + L L LD +N ++ P IR+ KL
Sbjct: 139 HLDLSSNKIQSI-YCTDLRVLHQMPLLNLSLD-LSLNPMNFIQP-GAFKEIRLHKLTLRN 195
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
N++ + ++ L L + L+ L + N S+ L + +
Sbjct: 196 NFDSLNVMKTCIQGL-------AGLEVHRLV----LGEFRNEGNLEKFDKSALEGLCNLT 244
Query: 261 LKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA--FANNTELEYLDLSNNNIAS 318
++ ++Y + ++ + + + ++V F+ N ++L+L N
Sbjct: 245 IEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFG- 303
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-----HLRSM 373
++ T + LK LK L + N+ S +++PSL L LSRN LS G +
Sbjct: 304 -QFPTLK-LKSLKRLTFTSNKGG--NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTT 359
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS---ISSNTLKYLNLNYNR 430
S+ LD+S + T+ + L GL+ + LD + L + + +S L YL++++
Sbjct: 360 SLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 418
Query: 431 ISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
N F L+ L L + GN F + F L LDLS
Sbjct: 419 TRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLS 464
Score = 47.2 bits (107), Expect = 2e-04
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAI---LNHN 290
SL +L +S N + ++S N L + L+++D + N+ Q + F SLR I ++H
Sbjct: 360 SLKYLDLSFNGVITMSS--NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHT 417
Query: 291 MVRYLESNAFANNTELEYLDLSNNNIA-SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
R + F + LE L ++ N+ + D F L+ L LDLS ++ + +
Sbjct: 418 HTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 477
Query: 350 EMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGL-QSIVELDLS 405
+ SL L +S N L + S+ +LD S + T K L+ S+ L+L+
Sbjct: 478 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 537
Query: 406 QN 407
QN
Sbjct: 538 QN 539
Score = 46.8 bits (106), Expect = 3e-04
Identities = 77/281 (27%), Positives = 124/281 (44%), Gaps = 19/281 (6%)
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL-NPNDVLLPATHLKILD-LSFNKFQTM 152
N L + +L ++T V + S N+ L L N P LK L L+F
Sbjct: 265 NCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NK 322
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQN--LI 208
G A E+ + PSLE L L + S G S G +++ L L+FN ++ + + L
Sbjct: 323 GGNAFSEVDL-PSLEFLDLSRNGL-SFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG 380
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLPSLTHLKMSNNY-RLELASSANNLFS-QSLKYID 265
L L + L ++ + + L +L +L +S+ + R+ N L S + LK
Sbjct: 381 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 440
Query: 266 ISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD 322
S+ P++ F LR L+ + L AF + + L+ L++S+NN SL
Sbjct: 441 NSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 498
Query: 323 TFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRN 362
++ L L+ LD S N I + L P SL L L++N
Sbjct: 499 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 539
Score = 44.0 bits (99), Expect = 0.002
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 74 FTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVL 133
F K P++L + NLD+S N L+ L + ++ L+VL+LSR + +
Sbjct: 5 FYKIPDNLP--FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR----CEIQTIEDGAY 58
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
+HL L L+ N Q++ A L SL+ L+ + S+ P+ L ++
Sbjct: 59 QSLSHLSTLILTGNPIQSLALGAFSGL---SSLQKLVAVETNLASLE-NFPIGHLKTLKE 114
Query: 194 LKLNFNPL--LRIQNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL 249
L + N + ++ S ++L L +S+ ++ S+ +L L + L +S L+L
Sbjct: 115 LNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS----LDL 170
Query: 250 ASSANNLFSQSLKYIDISYCNI-LQPNLKGFPSLRKAI--LNHNMVRYLESNAFANNTEL 306
+ + N F Q + +I + L+ N ++ I L V L F N L
Sbjct: 171 SLNPMN-FIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNL 229
Query: 307 EYLDLSN-NNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
E D S + +L + FR + +LD + + S + S+T ++ +++
Sbjct: 230 EKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVT-IERVKDFSY 288
Query: 366 RVG--HLRSMSVTILDMSSCELNTIGK---DSLEG--------LQSIVELDLSQNLLSY- 411
G HL ++ + +L ++ + S +G L S+ LDLS+N LS+
Sbjct: 289 NFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK 348
Query: 412 ---IPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNP 468
+ +LKYL+L++N + ++++ F L +L L + + S F S
Sbjct: 349 GCCSQSDFGTTSLKYLDLSFNGVITMSS-NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLR 407
Query: 469 YLERLDLS 476
L LD+S
Sbjct: 408 NLIYLDIS 415
>AL160272-1|CAH72618.1| 839|Homo sapiens toll-like receptor 4
protein.
Length = 839
Score = 70.9 bits (166), Expect = 2e-11
Identities = 102/404 (25%), Positives = 185/404 (45%), Gaps = 49/404 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNN--EFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
++ + L + P G + +LN+++N + K PE S L NL +LD+SSN+++ +
Sbjct: 134 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCT 193
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT--HLKILDLSF-NKFQTMGNLANQ-E 159
L L + +LNLS + L+LNP + + P +++ L+ N F ++ + +
Sbjct: 194 DLRVLHQMPLLNLSLD-----LSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQ 248
Query: 160 LLIRPSLETLILDHC--EIN-SIHGRSPLSGLINIRV-------LKLNFNPLLRIQNLIS 209
L + L+L E N +S L GL N+ + L + ++ + N ++
Sbjct: 249 GLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLT 308
Query: 210 S----SLRSLFVSNCELTSLN----HNELMFLP--SLTHLKMSNNYRLELASS-ANNLFS 258
+ SL S+ + + S N H EL+ LK+ + RL S+ N FS
Sbjct: 309 NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFS 368
Query: 259 Q----SLKYIDIS-----YCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
+ SL+++D+S + + G SL+ L+ N V + SN F +LE+L
Sbjct: 369 EVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHL 427
Query: 310 DLSNNNIASL-RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLS-----RNY 363
D ++N+ + + F L+ L +LD+S V + SL LK++ N+
Sbjct: 428 DFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENF 487
Query: 364 LSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
L + ++T LD+S C+L + + L S+ L++S N
Sbjct: 488 LPDI-FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 530
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 35 FLCRCNLDKTDIDCS--RRGLTDIPNGLG-LQVTKLNISNNEFTKFPESLSRLHNLVNLD 91
FL NL DI + R I NGL L+V K+ ++ + P+ + L NL LD
Sbjct: 443 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD 502
Query: 92 ISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQT 151
+S QL+ L A +L++L+VLN+S N F S L+ P L L++LD S N T
Sbjct: 503 LSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFS-LDTFPYKCL---NSLQVLDYSLNHIMT 558
Score = 48.4 bits (110), Expect = 9e-05
Identities = 96/406 (23%), Positives = 172/406 (42%), Gaps = 36/406 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
LS L LV ++ + L+ P + +L L+ LN++ N S+ + T+L+
Sbjct: 125 LSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLIQSF---KLPEYFSNLTNLE 178
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
LDLS NK Q++ + +L + L L LD +N ++ P IR+ KL
Sbjct: 179 HLDLSSNKIQSI-YCTDLRVLHQMPLLNLSLD-LSLNPMNFIQP-GAFKEIRLHKLTLRN 235
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
N++ + ++ L L + L+ L + N S+ L + +
Sbjct: 236 NFDSLNVMKTCIQGL-------AGLEVHRLV----LGEFRNEGNLEKFDKSALEGLCNLT 284
Query: 261 LKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA--FANNTELEYLDLSNNNIAS 318
++ ++Y + ++ + + + ++V F+ N ++L+L N
Sbjct: 285 IEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFG- 343
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-----HLRSM 373
++ T + LK LK L + N+ S +++PSL L LSRN LS G +
Sbjct: 344 -QFPTLK-LKSLKRLTFTSNKGG--NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTT 399
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS---ISSNTLKYLNLNYNR 430
S+ LD+S + T+ + L GL+ + LD + L + + +S L YL++++
Sbjct: 400 SLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 458
Query: 431 ISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
N F L+ L L + GN F + F L LDLS
Sbjct: 459 TRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLS 504
Score = 47.2 bits (107), Expect = 2e-04
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAI---LNHN 290
SL +L +S N + ++S N L + L+++D + N+ Q + F SLR I ++H
Sbjct: 400 SLKYLDLSFNGVITMSS--NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHT 457
Query: 291 MVRYLESNAFANNTELEYLDLSNNNIA-SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
R + F + LE L ++ N+ + D F L+ L LDLS ++ + +
Sbjct: 458 HTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 517
Query: 350 EMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGL-QSIVELDLS 405
+ SL L +S N L + S+ +LD S + T K L+ S+ L+L+
Sbjct: 518 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 577
Query: 406 QN 407
QN
Sbjct: 578 QN 579
Score = 46.8 bits (106), Expect = 3e-04
Identities = 77/281 (27%), Positives = 124/281 (44%), Gaps = 19/281 (6%)
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL-NPNDVLLPATHLKILD-LSFNKFQTM 152
N L + +L ++T V + S N+ L L N P LK L L+F
Sbjct: 305 NCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NK 362
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQN--LI 208
G A E+ + PSLE L L + S G S G +++ L L+FN ++ + + L
Sbjct: 363 GGNAFSEVDL-PSLEFLDLSRNGL-SFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG 420
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLPSLTHLKMSNNY-RLELASSANNLFS-QSLKYID 265
L L + L ++ + + L +L +L +S+ + R+ N L S + LK
Sbjct: 421 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 480
Query: 266 ISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD 322
S+ P++ F LR L+ + L AF + + L+ L++S+NN SL
Sbjct: 481 NSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 538
Query: 323 TFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRN 362
++ L L+ LD S N I + L P SL L L++N
Sbjct: 539 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 579
Score = 44.0 bits (99), Expect = 0.002
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 74 FTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVL 133
F K P++L + NLD+S N L+ L + ++ L+VL+LSR + +
Sbjct: 45 FYKIPDNLP--FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR----CEIQTIEDGAY 98
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
+HL L L+ N Q++ A L SL+ L+ + S+ P+ L ++
Sbjct: 99 QSLSHLSTLILTGNPIQSLALGAFSGL---SSLQKLVAVETNLASLE-NFPIGHLKTLKE 154
Query: 194 LKLNFNPL--LRIQNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL 249
L + N + ++ S ++L L +S+ ++ S+ +L L + L +S L+L
Sbjct: 155 LNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS----LDL 210
Query: 250 ASSANNLFSQSLKYIDISYCNI-LQPNLKGFPSLRKAI--LNHNMVRYLESNAFANNTEL 306
+ + N F Q + +I + L+ N ++ I L V L F N L
Sbjct: 211 SLNPMN-FIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNL 269
Query: 307 EYLDLSN-NNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
E D S + +L + FR + +LD + + S + S+T ++ +++
Sbjct: 270 EKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVT-IERVKDFSY 328
Query: 366 RVG--HLRSMSVTILDMSSCELNTIGK---DSLEG--------LQSIVELDLSQNLLSY- 411
G HL ++ + +L ++ + S +G L S+ LDLS+N LS+
Sbjct: 329 NFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK 388
Query: 412 ---IPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNP 468
+ +LKYL+L++N + ++++ F L +L L + + S F S
Sbjct: 389 GCCSQSDFGTTSLKYLDLSFNGVITMSS-NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLR 447
Query: 469 YLERLDLS 476
L LD+S
Sbjct: 448 NLIYLDIS 455
>AF177765-1|AAF05316.1| 839|Homo sapiens toll-like receptor 4
protein.
Length = 839
Score = 70.9 bits (166), Expect = 2e-11
Identities = 102/404 (25%), Positives = 185/404 (45%), Gaps = 49/404 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNN--EFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
++ + L + P G + +LN+++N + K PE S L NL +LD+SSN+++ +
Sbjct: 134 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCT 193
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT--HLKILDLSF-NKFQTMGNLANQ-E 159
L L + +LNLS + L+LNP + + P +++ L+ N F ++ + +
Sbjct: 194 DLRVLHQMPLLNLSLD-----LSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQ 248
Query: 160 LLIRPSLETLILDHC--EIN-SIHGRSPLSGLINIRV-------LKLNFNPLLRIQNLIS 209
L + L+L E N +S L GL N+ + L + ++ + N ++
Sbjct: 249 GLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLT 308
Query: 210 S----SLRSLFVSNCELTSLN----HNELMFLP--SLTHLKMSNNYRLELASS-ANNLFS 258
+ SL S+ + + S N H EL+ LK+ + RL S+ N FS
Sbjct: 309 NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFS 368
Query: 259 Q----SLKYIDIS-----YCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
+ SL+++D+S + + G SL+ L+ N V + SN F +LE+L
Sbjct: 369 EVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHL 427
Query: 310 DLSNNNIASL-RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLS-----RNY 363
D ++N+ + + F L+ L +LD+S V + SL LK++ N+
Sbjct: 428 DFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENF 487
Query: 364 LSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
L + ++T LD+S C+L + + L S+ L++S N
Sbjct: 488 LPDI-FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 530
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 35 FLCRCNLDKTDIDCS--RRGLTDIPNGLG-LQVTKLNISNNEFTKFPESLSRLHNLVNLD 91
FL NL DI + R I NGL L+V K+ ++ + P+ + L NL LD
Sbjct: 443 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD 502
Query: 92 ISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQT 151
+S QL+ L A +L++L+VLN+S N F S L+ P L L++LD S N T
Sbjct: 503 LSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFS-LDTFPYKCL---NSLQVLDYSLNHIMT 558
Score = 48.4 bits (110), Expect = 9e-05
Identities = 96/406 (23%), Positives = 172/406 (42%), Gaps = 36/406 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
LS L LV ++ + L+ P + +L L+ LN++ N S+ + T+L+
Sbjct: 125 LSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLIQSF---KLPEYFSNLTNLE 178
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
LDLS NK Q++ + +L + L L LD +N ++ P IR+ KL
Sbjct: 179 HLDLSSNKIQSI-YCTDLRVLHQMPLLNLSLD-LSLNPMNFIQP-GAFKEIRLHKLTLRN 235
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
N++ + ++ L L + L+ L + N S+ L + +
Sbjct: 236 NFDSLNVMKTCIQGL-------AGLEVHRLV----LGEFRNEGNLEKFDKSALEGLCNLT 284
Query: 261 LKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA--FANNTELEYLDLSNNNIAS 318
++ ++Y + ++ + + + ++V F+ N ++L+L N
Sbjct: 285 IEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFG- 343
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-----HLRSM 373
++ T + LK LK L + N+ S +++PSL L LSRN LS G +
Sbjct: 344 -QFPTLK-LKSLKRLTFTSNKGG--NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTT 399
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS---ISSNTLKYLNLNYNR 430
S+ LD+S + T+ + L GL+ + LD + L + + +S L YL++++
Sbjct: 400 SLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 458
Query: 431 ISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
N F L+ L L + GN F + F L LDLS
Sbjct: 459 TRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLS 504
Score = 47.2 bits (107), Expect = 2e-04
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAI---LNHN 290
SL +L +S N + ++S N L + L+++D + N+ Q + F SLR I ++H
Sbjct: 400 SLKYLDLSFNGVITMSS--NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHT 457
Query: 291 MVRYLESNAFANNTELEYLDLSNNNIA-SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
R + F + LE L ++ N+ + D F L+ L LDLS ++ + +
Sbjct: 458 HTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 517
Query: 350 EMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGL-QSIVELDLS 405
+ SL L +S N L + S+ +LD S + T K L+ S+ L+L+
Sbjct: 518 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 577
Query: 406 QN 407
QN
Sbjct: 578 QN 579
Score = 46.8 bits (106), Expect = 3e-04
Identities = 77/281 (27%), Positives = 124/281 (44%), Gaps = 19/281 (6%)
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL-NPNDVLLPATHLKILD-LSFNKFQTM 152
N L + +L ++T V + S N+ L L N P LK L L+F
Sbjct: 305 NCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NK 362
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQN--LI 208
G A E+ + PSLE L L + S G S G +++ L L+FN ++ + + L
Sbjct: 363 GGNAFSEVDL-PSLEFLDLSRNGL-SFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG 420
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLPSLTHLKMSNNY-RLELASSANNLFS-QSLKYID 265
L L + L ++ + + L +L +L +S+ + R+ N L S + LK
Sbjct: 421 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 480
Query: 266 ISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD 322
S+ P++ F LR L+ + L AF + + L+ L++S+NN SL
Sbjct: 481 NSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 538
Query: 323 TFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRN 362
++ L L+ LD S N I + L P SL L L++N
Sbjct: 539 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 579
Score = 44.0 bits (99), Expect = 0.002
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 74 FTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVL 133
F K P++L + NLD+S N L+ L + ++ L+VL+LSR + +
Sbjct: 45 FYKIPDNLP--FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR----CEIQTIEDGAY 98
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
+HL L L+ N Q++ A L SL+ L+ + S+ P+ L ++
Sbjct: 99 QSLSHLSTLILTGNPIQSLALGAFSGL---SSLQKLVAVETNLASLE-NFPIGHLKTLKE 154
Query: 194 LKLNFNPL--LRIQNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL 249
L + N + ++ S ++L L +S+ ++ S+ +L L + L +S L+L
Sbjct: 155 LNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS----LDL 210
Query: 250 ASSANNLFSQSLKYIDISYCNI-LQPNLKGFPSLRKAI--LNHNMVRYLESNAFANNTEL 306
+ + N F Q + +I + L+ N ++ I L V L F N L
Sbjct: 211 SLNPMN-FIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNL 269
Query: 307 EYLDLSN-NNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
E D S + +L + FR + +LD + + S + S+T ++ +++
Sbjct: 270 EKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVT-IERVKDFSY 328
Query: 366 RVG--HLRSMSVTILDMSSCELNTIGK---DSLEG--------LQSIVELDLSQNLLSY- 411
G HL ++ + +L ++ + S +G L S+ LDLS+N LS+
Sbjct: 329 NFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK 388
Query: 412 ---IPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNP 468
+ +LKYL+L++N + ++++ F L +L L + + S F S
Sbjct: 389 GCCSQSDFGTTSLKYLDLSFNGVITMSS-NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLR 447
Query: 469 YLERLDLS 476
L LD+S
Sbjct: 448 NLIYLDIS 455
>AF172171-1|AAF89753.1| 839|Homo sapiens toll-like receptor 4
protein.
Length = 839
Score = 70.9 bits (166), Expect = 2e-11
Identities = 102/404 (25%), Positives = 185/404 (45%), Gaps = 49/404 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNN--EFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
++ + L + P G + +LN+++N + K PE S L NL +LD+SSN+++ +
Sbjct: 134 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCT 193
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT--HLKILDLSF-NKFQTMGNLANQ-E 159
L L + +LNLS + L+LNP + + P +++ L+ N F ++ + +
Sbjct: 194 DLRVLHQMPLLNLSLD-----LSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQ 248
Query: 160 LLIRPSLETLILDHC--EIN-SIHGRSPLSGLINIRV-------LKLNFNPLLRIQNLIS 209
L + L+L E N +S L GL N+ + L + ++ + N ++
Sbjct: 249 GLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLT 308
Query: 210 S----SLRSLFVSNCELTSLN----HNELMFLP--SLTHLKMSNNYRLELASS-ANNLFS 258
+ SL S+ + + S N H EL+ LK+ + RL S+ N FS
Sbjct: 309 NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFS 368
Query: 259 Q----SLKYIDIS-----YCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
+ SL+++D+S + + G SL+ L+ N V + SN F +LE+L
Sbjct: 369 EVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHL 427
Query: 310 DLSNNNIASL-RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLS-----RNY 363
D ++N+ + + F L+ L +LD+S V + SL LK++ N+
Sbjct: 428 DFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENF 487
Query: 364 LSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
L + ++T LD+S C+L + + L S+ L++S N
Sbjct: 488 LPDI-FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 530
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 35 FLCRCNLDKTDIDCS--RRGLTDIPNGLG-LQVTKLNISNNEFTKFPESLSRLHNLVNLD 91
FL NL DI + R I NGL L+V K+ ++ + P+ + L NL LD
Sbjct: 443 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD 502
Query: 92 ISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQT 151
+S QL+ L A +L++L+VLN+S N F S L+ P L L++LD S N T
Sbjct: 503 LSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFS-LDTFPYKCL---NSLQVLDYSLNHIMT 558
Score = 48.4 bits (110), Expect = 9e-05
Identities = 96/406 (23%), Positives = 172/406 (42%), Gaps = 36/406 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
LS L LV ++ + L+ P + +L L+ LN++ N S+ + T+L+
Sbjct: 125 LSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLIQSF---KLPEYFSNLTNLE 178
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
LDLS NK Q++ + +L + L L LD +N ++ P IR+ KL
Sbjct: 179 HLDLSSNKIQSI-YCTDLRVLHQMPLLNLSLD-LSLNPMNFIQP-GAFKEIRLHKLTLRN 235
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
N++ + ++ L L + L+ L + N S+ L + +
Sbjct: 236 NFDSLNVMKTCIQGL-------AGLEVHRLV----LGEFRNEGNLEKFDKSALEGLCNLT 284
Query: 261 LKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA--FANNTELEYLDLSNNNIAS 318
++ ++Y + ++ + + + ++V F+ N ++L+L N
Sbjct: 285 IEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFG- 343
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-----HLRSM 373
++ T + LK LK L + N+ S +++PSL L LSRN LS G +
Sbjct: 344 -QFPTLK-LKSLKRLTFTSNKGG--NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTT 399
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS---ISSNTLKYLNLNYNR 430
S+ LD+S + T+ + L GL+ + LD + L + + +S L YL++++
Sbjct: 400 SLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 458
Query: 431 ISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
N F L+ L L + GN F + F L LDLS
Sbjct: 459 TRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLS 504
Score = 47.2 bits (107), Expect = 2e-04
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAI---LNHN 290
SL +L +S N + ++S N L + L+++D + N+ Q + F SLR I ++H
Sbjct: 400 SLKYLDLSFNGVITMSS--NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHT 457
Query: 291 MVRYLESNAFANNTELEYLDLSNNNIA-SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
R + F + LE L ++ N+ + D F L+ L LDLS ++ + +
Sbjct: 458 HTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 517
Query: 350 EMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGL-QSIVELDLS 405
+ SL L +S N L + S+ +LD S + T K L+ S+ L+L+
Sbjct: 518 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 577
Query: 406 QN 407
QN
Sbjct: 578 QN 579
Score = 46.8 bits (106), Expect = 3e-04
Identities = 77/281 (27%), Positives = 124/281 (44%), Gaps = 19/281 (6%)
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL-NPNDVLLPATHLKILD-LSFNKFQTM 152
N L + +L ++T V + S N+ L L N P LK L L+F
Sbjct: 305 NCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NK 362
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQN--LI 208
G A E+ + PSLE L L + S G S G +++ L L+FN ++ + + L
Sbjct: 363 GGNAFSEVDL-PSLEFLDLSRNGL-SFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG 420
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLPSLTHLKMSNNY-RLELASSANNLFS-QSLKYID 265
L L + L ++ + + L +L +L +S+ + R+ N L S + LK
Sbjct: 421 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 480
Query: 266 ISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD 322
S+ P++ F LR L+ + L AF + + L+ L++S+NN SL
Sbjct: 481 NSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 538
Query: 323 TFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRN 362
++ L L+ LD S N I + L P SL L L++N
Sbjct: 539 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 579
Score = 44.0 bits (99), Expect = 0.002
Identities = 100/428 (23%), Positives = 185/428 (43%), Gaps = 42/428 (9%)
Query: 74 FTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVL 133
F K P++L + NLD+S N L+ L + ++ L+VL+LSR + +
Sbjct: 45 FYKIPDNLP--FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR----CEIQTIEDGAY 98
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
+HL L L+ N Q++ A L SL+ L+ + S+ P+ L ++
Sbjct: 99 QSLSHLSTLILTGNPIQSLALGAFSGL---SSLQKLVAVETNLASLE-NFPIGHLKTLKE 154
Query: 194 LKLNFNPL--LRIQNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL 249
L + N + ++ S ++L L +S+ ++ S+ +L L + L +S L+L
Sbjct: 155 LNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS----LDL 210
Query: 250 ASSANNLFSQSLKYIDISYCNI-LQPNLKGFPSLRKAI--LNHNMVRYLESNAFANNTEL 306
+ + N F Q + +I + L+ N ++ I L V L F N L
Sbjct: 211 SLNPMN-FIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNL 269
Query: 307 EYLDLSN-NNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
E D S + +L + FR + +LD + + S + S+T ++ +++
Sbjct: 270 EKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVT-IERVKDFSY 328
Query: 366 RVG--HLRSMSVTILDMSSCELNTIGK---DSLEG--------LQSIVELDLSQNLLSY- 411
G HL ++ + +L ++ + S +G L S+ LDLS+N LS+
Sbjct: 329 NFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK 388
Query: 412 ---IPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNP 468
+ +LKYL+L++N + ++++ F L +L L + + S F S
Sbjct: 389 GCCSQSDFGTTSLKYLDLSFNGVITMSS-NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLR 447
Query: 469 YLERLDLS 476
L LD+S
Sbjct: 448 NLIYLDIS 455
>AB017169-1|BAA35186.1| 1523|Homo sapiens Slit-3 protein protein.
Length = 1523
Score = 70.9 bits (166), Expect = 2e-11
Identities = 111/484 (22%), Positives = 195/484 (40%), Gaps = 60/484 (12%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQ 96
+C +DC GL +P G+ +L++ N T+ + + L NL L + NQ
Sbjct: 37 KCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQ 96
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ + A +L LE L L++N L + P + L LDLS N+ Q + A
Sbjct: 97 VSVIERGAFQDLKQLERLRLNKNK----LQVLPELLFQSTPKLTRLDLSENQIQGIPRKA 152
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
+ + ++ L LD+ I+ I L ++ +L LN N + RI L++S
Sbjct: 153 FRGI---TDVKNLQLDNNHISCIED-GAFRALRDLEILTLNNNNISRI--LVTSFNHMPK 206
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ L S NH L HL +++ + + F+ + + + N+
Sbjct: 207 IRTLRLHS-NH-----LYCDCHLAWLSDWLRQRRTVGQ--FTLCMAPVHLRGFNVADVQK 258
Query: 277 KGF----PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
K + P N N + +NN +D + + + G+ ++
Sbjct: 259 KEYVCPAPHSEPPSCNANSISCPSPCTCSNN----IVDCRGKGLMEIPANLPEGIVEIR- 313
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDS 392
L N I IP + + L ++ +S+N +S I D+
Sbjct: 314 --LEQNSIKAIPAGAFTQYKKLKRIDISKNQIS---------------------DIAPDA 350
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
+GL+S+ L L N ++ I + +L+ L LN N+I+ + TF L L LS+
Sbjct: 351 FQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSL 410
Query: 451 VGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLI 510
N+ I + F ++ L L+ N + CDC + + D+ L+ N E S
Sbjct: 411 YDNKLQTI-SKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADY-----LQDNPIETS-GAR 463
Query: 511 CNSP 514
C+SP
Sbjct: 464 CSSP 467
Score = 57.2 bits (132), Expect = 2e-07
Identities = 28/82 (34%), Positives = 44/82 (53%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQL 97
+C +T + CS +GL +P G+ VT+L + N T P LS L +L +D+S+N +
Sbjct: 728 QCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSI 787
Query: 98 KGLPDNALYNLTALEVLNLSRN 119
L + N++ L L LS N
Sbjct: 788 SMLTNYTFSNMSHLSTLILSYN 809
Score = 53.6 bits (123), Expect = 2e-06
Identities = 73/319 (22%), Positives = 136/319 (42%), Gaps = 20/319 (6%)
Query: 66 KLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
K+N+SNN+ + E + ++ L ++ NQL+ + L+ L+ L L N
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNL---- 616
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD---HCEI----N 177
+ ND + +++L L N+ T+ A L+ ++ L +C +
Sbjct: 617 IGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGK 676
Query: 178 SIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR--SLFVSNCELTSLNHNELMFLPS 235
+ R +SG N R K F + IQ++ S+C+L+ + + +
Sbjct: 677 WLRKRRIVSG--NPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMET 734
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYL 295
+ ++ SN L ++ Y++ ++ + L L L++N + L
Sbjct: 735 V--VRCSNKGLRALPRGMPKDVTEL--YLEGNHLTAVPRELSALRHLTLIDLSNNSISML 790
Query: 296 ESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLT 355
+ F+N + L L LS N + + F GL+ L+ L L N+I+ +PE S ++ SL+
Sbjct: 791 TNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLS 850
Query: 356 QLKLSRNYLSRVGHLRSMS 374
L L N L LR +S
Sbjct: 851 HLALGTNPLHCDCSLRWLS 869
Score = 45.6 bits (103), Expect = 7e-04
Identities = 24/88 (27%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES--LSRLHNLVNLDISSN 95
+C + T +DCS + L IP+ L VT L +++NE + + +L NL +++S+N
Sbjct: 508 KCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNN 567
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDS 123
++K + + A +++ L L+ N ++
Sbjct: 568 KIKEVREGAFDGAASVQELMLTGNQLET 595
Score = 45.6 bits (103), Expect = 7e-04
Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 375 VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRIS 432
VT L + L + ++ L L+ + +DLS N +S + + SN L L L+YNR+
Sbjct: 754 VTELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLR 812
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
I F L L L++ GN + + SF D L L L N CDCS
Sbjct: 813 CIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTS-LSHLALGTNPLHCDCS 864
>AB011538-1|BAA32466.2| 1559|Homo sapiens MEGF5 protein.
Length = 1559
Score = 70.9 bits (166), Expect = 2e-11
Identities = 111/484 (22%), Positives = 195/484 (40%), Gaps = 60/484 (12%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQ 96
+C +DC GL +P G+ +L++ N T+ + + L NL L + NQ
Sbjct: 73 KCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQ 132
Query: 97 LKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLA 156
+ + A +L LE L L++N L + P + L LDLS N+ Q + A
Sbjct: 133 VSVIERGAFQDLKQLERLRLNKNK----LQVLPELLFQSTPKLTRLDLSENQIQGIPRKA 188
Query: 157 NQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF 216
+ + ++ L LD+ I+ I L ++ +L LN N + RI L++S
Sbjct: 189 FRGI---TDVKNLQLDNNHISCIED-GAFRALRDLEILTLNNNNISRI--LVTSFNHMPK 242
Query: 217 VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNL 276
+ L S NH L HL +++ + + F+ + + + N+
Sbjct: 243 IRTLRLHS-NH-----LYCDCHLAWLSDWLRQRRTVGQ--FTLCMAPVHLRGFNVADVQK 294
Query: 277 KGF----PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
K + P N N + +NN +D + + + G+ ++
Sbjct: 295 KEYVCPAPHSEPPSCNANSISCPSPCTCSNN----IVDCRGKGLMEIPANLPEGIVEIR- 349
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDS 392
L N I IP + + L ++ +S+N +S I D+
Sbjct: 350 --LEQNSIKAIPAGAFTQYKKLKRIDISKNQIS---------------------DIAPDA 386
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
+GL+S+ L L N ++ I + +L+ L LN N+I+ + TF L L LS+
Sbjct: 387 FQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSL 446
Query: 451 VGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEESFNLI 510
N+ I + F ++ L L+ N + CDC + + D+ L+ N E S
Sbjct: 447 YDNKLQTI-SKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADY-----LQDNPIETS-GAR 499
Query: 511 CNSP 514
C+SP
Sbjct: 500 CSSP 503
Score = 57.2 bits (132), Expect = 2e-07
Identities = 28/82 (34%), Positives = 44/82 (53%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQL 97
+C +T + CS +GL +P G+ VT+L + N T P LS L +L +D+S+N +
Sbjct: 764 QCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSI 823
Query: 98 KGLPDNALYNLTALEVLNLSRN 119
L + N++ L L LS N
Sbjct: 824 SMLTNYTFSNMSHLSTLILSYN 845
Score = 53.6 bits (123), Expect = 2e-06
Identities = 73/319 (22%), Positives = 136/319 (42%), Gaps = 20/319 (6%)
Query: 66 KLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
K+N+SNN+ + E + ++ L ++ NQL+ + L+ L+ L L N
Sbjct: 597 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNL---- 652
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD---HCEI----N 177
+ ND + +++L L N+ T+ A L+ ++ L +C +
Sbjct: 653 IGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGK 712
Query: 178 SIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR--SLFVSNCELTSLNHNELMFLPS 235
+ R +SG N R K F + IQ++ S+C+L+ + + +
Sbjct: 713 WLRKRRIVSG--NPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMET 770
Query: 236 LTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYL 295
+ ++ SN L ++ Y++ ++ + L L L++N + L
Sbjct: 771 V--VRCSNKGLRALPRGMPKDVTEL--YLEGNHLTAVPRELSALRHLTLIDLSNNSISML 826
Query: 296 ESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLT 355
+ F+N + L L LS N + + F GL+ L+ L L N+I+ +PE S ++ SL+
Sbjct: 827 TNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLS 886
Query: 356 QLKLSRNYLSRVGHLRSMS 374
L L N L LR +S
Sbjct: 887 HLALGTNPLHCDCSLRWLS 905
Score = 45.6 bits (103), Expect = 7e-04
Identities = 24/88 (27%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES--LSRLHNLVNLDISSN 95
+C + T +DCS + L IP+ L VT L +++NE + + +L NL +++S+N
Sbjct: 544 KCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNN 603
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDS 123
++K + + A +++ L L+ N ++
Sbjct: 604 KIKEVREGAFDGAASVQELMLTGNQLET 631
Score = 45.6 bits (103), Expect = 7e-04
Identities = 37/113 (32%), Positives = 53/113 (46%), Gaps = 4/113 (3%)
Query: 375 VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRIS 432
VT L + L + ++ L L+ + +DLS N +S + + SN L L L+YNR+
Sbjct: 790 VTELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLR 848
Query: 433 SINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCS 485
I F L L L++ GN + + SF D L L L N CDCS
Sbjct: 849 CIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTS-LSHLALGTNPLHCDCS 900
>Z93015-1|CAI42364.1| 481|Homo sapiens nyctalopin protein.
Length = 481
Score = 70.5 bits (165), Expect = 2e-11
Identities = 66/231 (28%), Positives = 107/231 (46%), Gaps = 9/231 (3%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
+DL N + +G A L PSL L L H ++ I + GL + L+L N
Sbjct: 67 IDLDRNGLRFLGERAFGTL---PSLRRLSLRHNNLSFITPGA-FKGLPRLAELRLAHNGD 122
Query: 202 LRIQNLIS----SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLF 257
LR + + S LR L ++ C L S+ L LP+L L +N + + L
Sbjct: 123 LRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLA 182
Query: 258 SQSLKYIDISYCN-ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+ + +++ + +L+G LR L N VR + + AF + LE+L L++N +
Sbjct: 183 NLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 242
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
A L D FRGL+ L+ L+L N + + ++ L L L RN ++ V
Sbjct: 243 AELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFV 293
Score = 66.1 bits (154), Expect = 4e-10
Identities = 50/176 (28%), Positives = 84/176 (47%), Gaps = 6/176 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
+DL N + L F L L+ L L N ++ I + +P L +L+L+ N R
Sbjct: 67 IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
Query: 369 HLRSMSVTI----LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKY 423
H R+ + LD+++C L ++ + L L ++ EL NL +P ++ L +
Sbjct: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTH 186
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
+L RI ++ + + L RL SLS+ NR + +F D LE L L+DN+
Sbjct: 187 AHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCG-VLEHLLLNDNL 241
Score = 64.1 bits (149), Expect = 2e-09
Identities = 70/290 (24%), Positives = 123/290 (42%), Gaps = 30/290 (10%)
Query: 211 SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCN 270
SLR L + + L+ + LP L L++++N L + L+ +D++ C
Sbjct: 87 SLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACR 146
Query: 271 ILQ-PN--LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL 327
+ P L P+LR+ N+ R + A L + L I ++ + +GL
Sbjct: 147 LFSVPERLLAELPALRELAAFDNLFRRVPG-ALRGLANLTHAHLERGRIEAVASSSLQGL 205
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT 387
+ L+ L L N + + + + L L L+ N L+
Sbjct: 206 RRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAE--------------------- 244
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRL 445
+ D+ GL+ + L+L N L + + ++ L+ L L+ N I+ + F L+ L
Sbjct: 245 LPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGL 304
Query: 446 TSLSVVGNRFTMI-WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
+L + GNR T++ W F +L RL L N W CDC E +RD+ +
Sbjct: 305 LALHLNGNRLTVLAWVA--FQPGFFLGRLFLFRNPWCCDCRLEWLRDWME 352
>BC112242-1|AAI12243.1| 481|Homo sapiens nyctalopin protein.
Length = 481
Score = 70.5 bits (165), Expect = 2e-11
Identities = 66/231 (28%), Positives = 107/231 (46%), Gaps = 9/231 (3%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
+DL N + +G A L PSL L L H ++ I + GL + L+L N
Sbjct: 67 IDLDRNGLRFLGERAFGTL---PSLRRLSLRHNNLSFITPGA-FKGLPRLAELRLAHNGD 122
Query: 202 LRIQNLIS----SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLF 257
LR + + S LR L ++ C L S+ L LP+L L +N + + L
Sbjct: 123 LRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLA 182
Query: 258 SQSLKYIDISYCN-ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+ + +++ + +L+G LR L N VR + + AF + LE+L L++N +
Sbjct: 183 NLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 242
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
A L D FRGL+ L+ L+L N + + ++ L L L RN ++ V
Sbjct: 243 AELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFV 293
Score = 66.1 bits (154), Expect = 4e-10
Identities = 50/176 (28%), Positives = 84/176 (47%), Gaps = 6/176 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
+DL N + L F L L+ L L N ++ I + +P L +L+L+ N R
Sbjct: 67 IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
Query: 369 HLRSMSVTI----LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKY 423
H R+ + LD+++C L ++ + L L ++ EL NL +P ++ L +
Sbjct: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTH 186
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
+L RI ++ + + L RL SLS+ NR + +F D LE L L+DN+
Sbjct: 187 AHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCG-VLEHLLLNDNL 241
Score = 64.1 bits (149), Expect = 2e-09
Identities = 70/290 (24%), Positives = 123/290 (42%), Gaps = 30/290 (10%)
Query: 211 SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCN 270
SLR L + + L+ + LP L L++++N L + L+ +D++ C
Sbjct: 87 SLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACR 146
Query: 271 ILQ-PN--LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL 327
+ P L P+LR+ N+ R + A L + L I ++ + +GL
Sbjct: 147 LFSVPERLLAELPALRELAAFDNLFRRVPG-ALRGLANLTHAHLERGRIEAVASSSLQGL 205
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT 387
+ L+ L L N + + + + L L L+ N L+
Sbjct: 206 RRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAE--------------------- 244
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRL 445
+ D+ GL+ + L+L N L + + ++ L+ L L+ N I+ + F L+ L
Sbjct: 245 LPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGL 304
Query: 446 TSLSVVGNRFTMI-WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
+L + GNR T++ W F +L RL L N W CDC E +RD+ +
Sbjct: 305 LALHLNGNRLTVLAWVA--FQPGFFLGRLFLFRNPWCCDCRLEWLRDWME 352
>AJ278865-1|CAC19014.1| 481|Homo sapiens leucine-rich repeat
protein protein.
Length = 481
Score = 70.5 bits (165), Expect = 2e-11
Identities = 66/231 (28%), Positives = 107/231 (46%), Gaps = 9/231 (3%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
+DL N + +G A L PSL L L H ++ I + GL + L+L N
Sbjct: 67 IDLDRNGLRFLGERAFGTL---PSLRRLSLRHNNLSFITPGA-FKGLPRLAELRLAHNGD 122
Query: 202 LRIQNLIS----SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLF 257
LR + + S LR L ++ C L S+ L LP+L L +N + + L
Sbjct: 123 LRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLA 182
Query: 258 SQSLKYIDISYCN-ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+ + +++ + +L+G LR L N VR + + AF + LE+L L++N +
Sbjct: 183 NLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 242
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
A L D FRGL+ L+ L+L N + + ++ L L L RN ++ V
Sbjct: 243 AELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFV 293
Score = 66.1 bits (154), Expect = 4e-10
Identities = 50/176 (28%), Positives = 84/176 (47%), Gaps = 6/176 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
+DL N + L F L L+ L L N ++ I + +P L +L+L+ N R
Sbjct: 67 IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
Query: 369 HLRSMSVTI----LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKY 423
H R+ + LD+++C L ++ + L L ++ EL NL +P ++ L +
Sbjct: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTH 186
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
+L RI ++ + + L RL SLS+ NR + +F D LE L L+DN+
Sbjct: 187 AHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCG-VLEHLLLNDNL 241
Score = 64.1 bits (149), Expect = 2e-09
Identities = 70/290 (24%), Positives = 123/290 (42%), Gaps = 30/290 (10%)
Query: 211 SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCN 270
SLR L + + L+ + LP L L++++N L + L+ +D++ C
Sbjct: 87 SLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACR 146
Query: 271 ILQ-PN--LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL 327
+ P L P+LR+ N+ R + A L + L I ++ + +GL
Sbjct: 147 LFSVPERLLAELPALRELAAFDNLFRRVPG-ALRGLANLTHAHLERGRIEAVASSSLQGL 205
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT 387
+ L+ L L N + + + + L L L+ N L+
Sbjct: 206 RRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAE--------------------- 244
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRL 445
+ D+ GL+ + L+L N L + + ++ L+ L L+ N I+ + F L+ L
Sbjct: 245 LPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGL 304
Query: 446 TSLSVVGNRFTMI-WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
+L + GNR T++ W F +L RL L N W CDC E +RD+ +
Sbjct: 305 LALHLNGNRLTVLAWVA--FQPGFFLGRLFLFRNPWCCDCRLEWLRDWME 352
>AF254868-1|AAG42685.1| 481|Homo sapiens nyctalopin protein.
Length = 481
Score = 70.5 bits (165), Expect = 2e-11
Identities = 66/231 (28%), Positives = 107/231 (46%), Gaps = 9/231 (3%)
Query: 142 LDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPL 201
+DL N + +G A L PSL L L H ++ I + GL + L+L N
Sbjct: 67 IDLDRNGLRFLGERAFGTL---PSLRRLSLRHNNLSFITPGA-FKGLPRLAELRLAHNGD 122
Query: 202 LRIQNLIS----SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLF 257
LR + + S LR L ++ C L S+ L LP+L L +N + + L
Sbjct: 123 LRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLA 182
Query: 258 SQSLKYIDISYCN-ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+ + +++ + +L+G LR L N VR + + AF + LE+L L++N +
Sbjct: 183 NLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 242
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
A L D FRGL+ L+ L+L N + + ++ L L L RN ++ V
Sbjct: 243 AELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFV 293
Score = 66.1 bits (154), Expect = 4e-10
Identities = 50/176 (28%), Positives = 84/176 (47%), Gaps = 6/176 (3%)
Query: 309 LDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG 368
+DL N + L F L L+ L L N ++ I + +P L +L+L+ N R
Sbjct: 67 IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
Query: 369 HLRSMSVTI----LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKY 423
H R+ + LD+++C L ++ + L L ++ EL NL +P ++ L +
Sbjct: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTH 186
Query: 424 LNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNM 479
+L RI ++ + + L RL SLS+ NR + +F D LE L L+DN+
Sbjct: 187 AHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCG-VLEHLLLNDNL 241
Score = 64.1 bits (149), Expect = 2e-09
Identities = 70/290 (24%), Positives = 123/290 (42%), Gaps = 30/290 (10%)
Query: 211 SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCN 270
SLR L + + L+ + LP L L++++N L + L+ +D++ C
Sbjct: 87 SLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACR 146
Query: 271 ILQ-PN--LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL 327
+ P L P+LR+ N+ R + A L + L I ++ + +GL
Sbjct: 147 LFSVPERLLAELPALRELAAFDNLFRRVPG-ALRGLANLTHAHLERGRIEAVASSSLQGL 205
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT 387
+ L+ L L N + + + + L L L+ N L+
Sbjct: 206 RRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAE--------------------- 244
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRL 445
+ D+ GL+ + L+L N L + + ++ L+ L L+ N I+ + F L+ L
Sbjct: 245 LPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGL 304
Query: 446 TSLSVVGNRFTMI-WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYD 494
+L + GNR T++ W F +L RL L N W CDC E +RD+ +
Sbjct: 305 LALHLNGNRLTVLAWVA--FQPGFFLGRLFLFRNPWCCDCRLEWLRDWME 352
>AC108017-1|AAY41039.1| 260|Homo sapiens unknown protein.
Length = 260
Score = 70.1 bits (164), Expect = 3e-11
Identities = 44/144 (30%), Positives = 77/144 (53%), Gaps = 4/144 (2%)
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+G SL K L+HN + +L+ F + LE+L + +N+++ + TF GL L L L
Sbjct: 108 RGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLM 167
Query: 337 WNEIAVIPEDSLLE-MPSLTQLKLSRNYLSRVGHLRSMS---VTILDMSSCELNTIGKDS 392
N + +P+ L + MP L L L N++ + +L +S +T+L M ++N + +++
Sbjct: 168 NNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENT 227
Query: 393 LEGLQSIVELDLSQNLLSYIPDSI 416
LQ + ELDL N + +P I
Sbjct: 228 FAPLQKLDELDLGSNKIENLPPLI 251
Score = 67.7 bits (158), Expect = 1e-10
Identities = 62/213 (29%), Positives = 93/213 (43%), Gaps = 29/213 (13%)
Query: 273 QPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ NL+ PS+ + L N++R L + F N +L+ L L NN I S+ FRGL
Sbjct: 52 ETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 111
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTI 388
L L LS N I + ++ L L + N+LSR I
Sbjct: 112 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSR---------------------I 150
Query: 389 GKDSLEGLQSIVELDLSQNLLSYIPDSISSN---TLKYLNLNYNRISSINNLTFFMLNRL 445
+ GL S++ L L N+L+ +PD L +L+L N I ++ NLTF + L
Sbjct: 151 SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNL 210
Query: 446 TSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
T L + N+ + +F L+ LDL N
Sbjct: 211 TVLVMRKNKINHLNENTFAPLQK-LDELDLGSN 242
Score = 46.0 bits (104), Expect = 5e-04
Identities = 42/159 (26%), Positives = 73/159 (45%), Gaps = 3/159 (1%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCN 270
L+ L++ N ++TS++ L SLT L +S+N L +L I+ ++ +
Sbjct: 89 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLS 148
Query: 271 -ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNT-ELEYLDLSNNNIASLRYDTFRGLK 328
I P G SL +L +N++ L + L +LDL N+I +LR TF
Sbjct: 149 RISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCS 208
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV 367
L L + N+I + E++ + L +L L N + +
Sbjct: 209 NLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENL 247
Score = 37.5 bits (83), Expect = 0.17
Identities = 43/153 (28%), Positives = 64/153 (41%), Gaps = 8/153 (5%)
Query: 64 VTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
+TKL +S+N T P LH L L I N L + Y L +L +L L N
Sbjct: 113 LTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL- 171
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGR 182
+ L P +P H LDL N NL N + +L L++ +IN ++
Sbjct: 172 TRLPDKPLCQHMPRLHW--LDLEGNHIH---NLRNLTFISCSNLTVLVMRKNKINHLN-E 225
Query: 183 SPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
+ + L + L L N + + LI L+ L
Sbjct: 226 NTFAPLQKLDELDLGSNKIENLPPLIFKDLKEL 258
Score = 37.1 bits (82), Expect = 0.23
Identities = 37/152 (24%), Positives = 65/152 (42%), Gaps = 7/152 (4%)
Query: 210 SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
+SL L++S+ +T L L L L + +N+ + S + + + +
Sbjct: 111 NSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRI--SPPTFYGLNSLILLVLMN 168
Query: 270 NIL-----QPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTF 324
N+L +P + P L L N + L + F + + L L + N I L +TF
Sbjct: 169 NVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTF 228
Query: 325 RGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQ 356
L+ L LDL N+I +P ++ L+Q
Sbjct: 229 APLQKLDELDLGSNKIENLPPLIFKDLKELSQ 260
>D83597-1|BAA12019.1| 661|Homo sapiens RP105 protein.
Length = 661
Score = 69.7 bits (163), Expect = 3e-11
Identities = 66/233 (28%), Positives = 113/233 (48%), Gaps = 13/233 (5%)
Query: 234 PSLTHLKMSNNYR-LELA----SSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN 288
PSLTHL + N + L L NL + L + DI + LK L+ L+
Sbjct: 345 PSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLS 404
Query: 289 HNMVRYLESNAFANNTELEYLDLSNNNI-ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDS 347
HN L+S AF +LE LDL+ + + F+ L L+ L+L++ + +
Sbjct: 405 HNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHL 464
Query: 348 LLEMPSLTQLKLSRNY-----LSRVGHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVE 401
L +P L L L N+ +++ L+++ S+ +L +SSC L +I + + L +
Sbjct: 465 LAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSH 524
Query: 402 LDLSQNLLSYIP-DSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
+DLS N L+ DS+S YLNL N I+ I+ +L++ +++++ N
Sbjct: 525 VDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHN 577
Score = 58.0 bits (134), Expect = 1e-07
Identities = 82/311 (26%), Positives = 138/311 (44%), Gaps = 37/311 (11%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHN-LVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
+ V LN+ + F+ + + L LD+++ LKGLP + + L L+ L LS N+
Sbjct: 274 MSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLKKLVLSVNH 332
Query: 121 FDSWLNLNPNDVLLPATHL------KILDLSFNKFQTMGNLANQELL---IRPS------ 165
FD ++ + THL K L L + +GNL +L I S
Sbjct: 333 FDQLCQISAAN-FPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQ 391
Query: 166 ------LETLILDHCEINSIHGRS----PLSGLINIRVLKLNFN-PLLRIQNLISSSLRS 214
L+TL L H E + ++ P L+++ +L+ N P QNL L+
Sbjct: 392 LKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNL--HFLQV 449
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ--SLKYIDISYCNIL 272
L ++ C L + N + L LP L HL + N+ + + NL SL+ + +S C +L
Sbjct: 450 LNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLL 509
Query: 273 QPNLKGFPSLRK---AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKM 329
+ + F SL K L+HN + +S ++ + YL+L+ N+I + L
Sbjct: 510 SIDQQAFHSLGKMSHVDLSHNSLT-CDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQ 568
Query: 330 LKHLDLSWNEI 340
++LS N +
Sbjct: 569 QSTINLSHNPL 579
Score = 52.8 bits (121), Expect = 4e-06
Identities = 99/385 (25%), Positives = 160/385 (41%), Gaps = 40/385 (10%)
Query: 47 DCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+C GL++IP+ L L S N T + SRL NL LD++ Q+ + ++
Sbjct: 38 NCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTF 97
Query: 106 YNLTALEVLNLSRN--YFDSWLNLNPNDVLLPATHLKILDLSFN--KFQTMGNLANQELL 161
+ L L L+ N F + +LN L HL ++ + +F + NL N
Sbjct: 98 QSHHQLSTLVLTGNPLIFMAETSLNGPKSL---KHLFLIQTGISNLEFIPVHNLEN---- 150
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE 221
LE+L L I+SI N++VL N + I SL +
Sbjct: 151 ----LESLYLGSNHISSIKFPKDFPAR-NLKVLDFQNNAIHYISREDMRSLEQAINLSLN 205
Query: 222 LTSLNHN--ELMFLPSLTHLKMSNNYRLELASSANNL---FSQSL---KYIDISYCNILQ 273
N EL S ++ L+ N L +QSL + DI +I
Sbjct: 206 FNGNNVKGIELGAFDSTVFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISS 265
Query: 274 PNLKGFPSLRKAILNHNMVRY--LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLK 331
LKG + LN R+ + S F T+L+ LDL+ ++ L +GL +LK
Sbjct: 266 AMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLK 324
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY---------LSRVGHLRSMSVTILDMSS 382
L LS N + + S PSLT L + N L ++G+L+++ ++ D+ +
Sbjct: 325 KLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEA 384
Query: 383 CELNTIGKDSLEGLQSIVELDLSQN 407
+ ++ +L LQ+ L+LS N
Sbjct: 385 SDCCSLQLKNLSHLQT---LNLSHN 406
Score = 52.8 bits (121), Expect = 4e-06
Identities = 91/381 (23%), Positives = 153/381 (40%), Gaps = 34/381 (8%)
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
LP T + L+ SFN T+ N L+ +L L L C+IN IH +
Sbjct: 51 LPNT-TEFLEFSFNFLPTIHNRTFSRLM---NLTFLDLTRCQINWIH-EDTFQSHHQLST 105
Query: 194 LKLNFNPLLRIQNLISS---SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELA 250
L L NPL+ + + SL+ LF+ +++L + L +L L + +N+ +
Sbjct: 106 LVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNH-ISSI 164
Query: 251 SSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-----LNHNMVRYLESNAFANNTE 305
+ +++LK +D I + + SL +AI N N V+ +E AF ++T
Sbjct: 165 KFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAF-DSTV 223
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L+ S+ F GL+ L I ++ + S LK
Sbjct: 224 FQSLNFGGTPNLSV---IFNGLQNSTTQSLWLGTFEDIDDEDI----SSAMLK------- 269
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYL 424
L MSV L++ + I + + + ELDL+ L +P + N LK L
Sbjct: 270 ---GLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKL 326
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN-MWRCD 483
L+ N + ++ LT L + GN + + L+ LDLS N + D
Sbjct: 327 VLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASD 386
Query: 484 CSDENMRDFYDFVTLEPNKKE 504
C +++ TL + E
Sbjct: 387 CCSLQLKNLSHLQTLNLSHNE 407
>BC109070-1|AAI09071.1| 661|Homo sapiens CD180 molecule protein.
Length = 661
Score = 69.7 bits (163), Expect = 3e-11
Identities = 66/233 (28%), Positives = 113/233 (48%), Gaps = 13/233 (5%)
Query: 234 PSLTHLKMSNNYR-LELA----SSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN 288
PSLTHL + N + L L NL + L + DI + LK L+ L+
Sbjct: 345 PSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLS 404
Query: 289 HNMVRYLESNAFANNTELEYLDLSNNNI-ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDS 347
HN L+S AF +LE LDL+ + + F+ L L+ L+L++ + +
Sbjct: 405 HNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHL 464
Query: 348 LLEMPSLTQLKLSRNY-----LSRVGHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVE 401
L +P L L L N+ +++ L+++ S+ +L +SSC L +I + + L +
Sbjct: 465 LAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSH 524
Query: 402 LDLSQNLLSYIP-DSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
+DLS N L+ DS+S YLNL N I+ I+ +L++ +++++ N
Sbjct: 525 VDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHN 577
Score = 58.0 bits (134), Expect = 1e-07
Identities = 82/311 (26%), Positives = 138/311 (44%), Gaps = 37/311 (11%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHN-LVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
+ V LN+ + F+ + + L LD+++ LKGLP + + L L+ L LS N+
Sbjct: 274 MSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLKKLVLSVNH 332
Query: 121 FDSWLNLNPNDVLLPATHL------KILDLSFNKFQTMGNLANQELL---IRPS------ 165
FD ++ + THL K L L + +GNL +L I S
Sbjct: 333 FDQLCQISAAN-FPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQ 391
Query: 166 ------LETLILDHCEINSIHGRS----PLSGLINIRVLKLNFN-PLLRIQNLISSSLRS 214
L+TL L H E + ++ P L+++ +L+ N P QNL L+
Sbjct: 392 LKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNL--HFLQV 449
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ--SLKYIDISYCNIL 272
L ++ C L + N + L LP L HL + N+ + + NL SL+ + +S C +L
Sbjct: 450 LNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLL 509
Query: 273 QPNLKGFPSLRK---AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKM 329
+ + F SL K L+HN + +S ++ + YL+L+ N+I + L
Sbjct: 510 SIDQQAFHSLGKMSHVDLSHNSLT-CDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQ 568
Query: 330 LKHLDLSWNEI 340
++LS N +
Sbjct: 569 QSTINLSHNPL 579
Score = 52.8 bits (121), Expect = 4e-06
Identities = 99/385 (25%), Positives = 160/385 (41%), Gaps = 40/385 (10%)
Query: 47 DCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+C GL++IP+ L L S N T + SRL NL LD++ Q+ + ++
Sbjct: 38 NCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTF 97
Query: 106 YNLTALEVLNLSRN--YFDSWLNLNPNDVLLPATHLKILDLSFN--KFQTMGNLANQELL 161
+ L L L+ N F + +LN L HL ++ + +F + NL N
Sbjct: 98 QSHHQLSTLVLTGNPLIFMAETSLNGPKSL---KHLFLIQTGISNLEFIPVHNLEN---- 150
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE 221
LE+L L I+SI N++VL N + I SL +
Sbjct: 151 ----LESLYLGSNHISSIKFPKDFPAR-NLKVLDFQNNAIHYISREDMRSLEQAINLSLN 205
Query: 222 LTSLNHN--ELMFLPSLTHLKMSNNYRLELASSANNL---FSQSL---KYIDISYCNILQ 273
N EL S ++ L+ N L +QSL + DI +I
Sbjct: 206 FNGNNVKGIELGAFDSTVFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISS 265
Query: 274 PNLKGFPSLRKAILNHNMVRY--LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLK 331
LKG + LN R+ + S F T+L+ LDL+ ++ L +GL +LK
Sbjct: 266 AMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLK 324
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY---------LSRVGHLRSMSVTILDMSS 382
L LS N + + S PSLT L + N L ++G+L+++ ++ D+ +
Sbjct: 325 KLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEA 384
Query: 383 CELNTIGKDSLEGLQSIVELDLSQN 407
+ ++ +L LQ+ L+LS N
Sbjct: 385 SDCCSLQLKNLSHLQT---LNLSHN 406
Score = 52.8 bits (121), Expect = 4e-06
Identities = 91/381 (23%), Positives = 153/381 (40%), Gaps = 34/381 (8%)
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
LP T + L+ SFN T+ N L+ +L L L C+IN IH +
Sbjct: 51 LPNT-TEFLEFSFNFLPTIHNRTFSRLM---NLTFLDLTRCQINWIH-EDTFQSHHQLST 105
Query: 194 LKLNFNPLLRIQNLISS---SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELA 250
L L NPL+ + + SL+ LF+ +++L + L +L L + +N+ +
Sbjct: 106 LVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNH-ISSI 164
Query: 251 SSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-----LNHNMVRYLESNAFANNTE 305
+ +++LK +D I + + SL +AI N N V+ +E AF ++T
Sbjct: 165 KFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAF-DSTV 223
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L+ S+ F GL+ L I ++ + S LK
Sbjct: 224 FQSLNFGGTPNLSV---IFNGLQNSTTQSLWLGTFEDIDDEDI----SSAMLK------- 269
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYL 424
L MSV L++ + I + + + ELDL+ L +P + N LK L
Sbjct: 270 ---GLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKL 326
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN-MWRCD 483
L+ N + ++ LT L + GN + + L+ LDLS N + D
Sbjct: 327 VLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASD 386
Query: 484 CSDENMRDFYDFVTLEPNKKE 504
C +++ TL + E
Sbjct: 387 CCSLQLKNLSHLQTLNLSHNE 407
>BC109069-1|AAI09070.1| 661|Homo sapiens CD180 molecule protein.
Length = 661
Score = 69.7 bits (163), Expect = 3e-11
Identities = 66/233 (28%), Positives = 113/233 (48%), Gaps = 13/233 (5%)
Query: 234 PSLTHLKMSNNYR-LELA----SSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILN 288
PSLTHL + N + L L NL + L + DI + LK L+ L+
Sbjct: 345 PSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLS 404
Query: 289 HNMVRYLESNAFANNTELEYLDLSNNNI-ASLRYDTFRGLKMLKHLDLSWNEIAVIPEDS 347
HN L+S AF +LE LDL+ + + F+ L L+ L+L++ + +
Sbjct: 405 HNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHL 464
Query: 348 LLEMPSLTQLKLSRNY-----LSRVGHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVE 401
L +P L L L N+ +++ L+++ S+ +L +SSC L +I + + L +
Sbjct: 465 LAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSH 524
Query: 402 LDLSQNLLSYIP-DSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
+DLS N L+ DS+S YLNL N I+ I+ +L++ +++++ N
Sbjct: 525 VDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHN 577
Score = 58.0 bits (134), Expect = 1e-07
Identities = 82/311 (26%), Positives = 138/311 (44%), Gaps = 37/311 (11%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHN-LVNLDISSNQLKGLPDNALYNLTALEVLNLSRNY 120
+ V LN+ + F+ + + L LD+++ LKGLP + + L L+ L LS N+
Sbjct: 274 MSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLKKLVLSVNH 332
Query: 121 FDSWLNLNPNDVLLPATHL------KILDLSFNKFQTMGNLANQELL---IRPS------ 165
FD ++ + THL K L L + +GNL +L I S
Sbjct: 333 FDQLCQISAAN-FPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQ 391
Query: 166 ------LETLILDHCEINSIHGRS----PLSGLINIRVLKLNFN-PLLRIQNLISSSLRS 214
L+TL L H E + ++ P L+++ +L+ N P QNL L+
Sbjct: 392 LKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNL--HFLQV 449
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQ--SLKYIDISYCNIL 272
L ++ C L + N + L LP L HL + N+ + + NL SL+ + +S C +L
Sbjct: 450 LNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLL 509
Query: 273 QPNLKGFPSLRK---AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKM 329
+ + F SL K L+HN + +S ++ + YL+L+ N+I + L
Sbjct: 510 SIDQQAFHSLGKMSHVDLSHNSLT-CDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQ 568
Query: 330 LKHLDLSWNEI 340
++LS N +
Sbjct: 569 QSTINLSHNPL 579
Score = 52.8 bits (121), Expect = 4e-06
Identities = 99/385 (25%), Positives = 160/385 (41%), Gaps = 40/385 (10%)
Query: 47 DCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSNQLKGLPDNAL 105
+C GL++IP+ L L S N T + SRL NL LD++ Q+ + ++
Sbjct: 38 NCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTF 97
Query: 106 YNLTALEVLNLSRN--YFDSWLNLNPNDVLLPATHLKILDLSFN--KFQTMGNLANQELL 161
+ L L L+ N F + +LN L HL ++ + +F + NL N
Sbjct: 98 QSHHQLSTLVLTGNPLIFMAETSLNGPKSL---KHLFLIQTGISNLEFIPVHNLEN---- 150
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE 221
LE+L L I+SI N++VL N + I SL +
Sbjct: 151 ----LESLYLGSNHISSIKFPKDFPAR-NLKVLDFQNNAIHYISREDMRSLEQAINLSLN 205
Query: 222 LTSLNHN--ELMFLPSLTHLKMSNNYRLELASSANNL---FSQSL---KYIDISYCNILQ 273
N EL S ++ L+ N L +QSL + DI +I
Sbjct: 206 FNGNNVKGIELGAFDSTVFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISS 265
Query: 274 PNLKGFPSLRKAILNHNMVRY--LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLK 331
LKG + LN R+ + S F T+L+ LDL+ ++ L +GL +LK
Sbjct: 266 AMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SGMKGLNLLK 324
Query: 332 HLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY---------LSRVGHLRSMSVTILDMSS 382
L LS N + + S PSLT L + N L ++G+L+++ ++ D+ +
Sbjct: 325 KLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEA 384
Query: 383 CELNTIGKDSLEGLQSIVELDLSQN 407
+ ++ +L LQ+ L+LS N
Sbjct: 385 SDCCSLQLKNLSHLQT---LNLSHN 406
Score = 52.8 bits (121), Expect = 4e-06
Identities = 91/381 (23%), Positives = 153/381 (40%), Gaps = 34/381 (8%)
Query: 134 LPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRV 193
LP T + L+ SFN T+ N L+ +L L L C+IN IH +
Sbjct: 51 LPNT-TEFLEFSFNFLPTIHNRTFSRLM---NLTFLDLTRCQINWIH-EDTFQSHHQLST 105
Query: 194 LKLNFNPLLRIQNLISS---SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELA 250
L L NPL+ + + SL+ LF+ +++L + L +L L + +N+ +
Sbjct: 106 LVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNH-ISSI 164
Query: 251 SSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI-----LNHNMVRYLESNAFANNTE 305
+ +++LK +D I + + SL +AI N N V+ +E AF ++T
Sbjct: 165 KFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAF-DSTV 223
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
+ L+ S+ F GL+ L I ++ + S LK
Sbjct: 224 FQSLNFGGTPNLSV---IFNGLQNSTTQSLWLGTFEDIDDEDI----SSAMLK------- 269
Query: 366 RVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYL 424
L MSV L++ + I + + + ELDL+ L +P + N LK L
Sbjct: 270 ---GLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKL 326
Query: 425 NLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN-MWRCD 483
L+ N + ++ LT L + GN + + L+ LDLS N + D
Sbjct: 327 VLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASD 386
Query: 484 CSDENMRDFYDFVTLEPNKKE 504
C +++ TL + E
Sbjct: 387 CCSLQLKNLSHLQTLNLSHNE 407
>AF177766-1|AAF07823.1| 752|Homo sapiens human toll-like receptor 4
protein.
Length = 752
Score = 69.7 bits (163), Expect = 3e-11
Identities = 102/404 (25%), Positives = 185/404 (45%), Gaps = 49/404 (12%)
Query: 46 IDCSRRGLTDIPNGLGLQVTKLNISNN--EFTKFPESLSRLHNLVNLDISSNQLKGLPDN 103
++ + L + P G + +LN+++N + K PE S L NL +LD+SSN+++ +
Sbjct: 47 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCT 106
Query: 104 ALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPAT--HLKILDLSF-NKFQTMGNLANQ-E 159
L L + +LNLS + L+LNP + + P +++ L+ N F ++ + +
Sbjct: 107 DLRVLHQMPLLNLSLD-----LSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQ 161
Query: 160 LLIRPSLETLILDHC--EIN-SIHGRSPLSGLINIRV-------LKLNFNPLLRIQNLIS 209
L + L+L E N +S L GL N+ + L + ++ + N ++
Sbjct: 162 GLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDGIIDLFNCLT 221
Query: 210 S----SLRSLFVSNCELTSLN----HNELMFLP--SLTHLKMSNNYRLELASS-ANNLFS 258
+ SL S+ + + S N H EL+ LK+ + RL S+ N FS
Sbjct: 222 NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFS 281
Query: 259 Q----SLKYIDIS-----YCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
+ SL+++D+S + + G SL+ L+ N V + SN F +LE+L
Sbjct: 282 EVDLPSLEFLDLSRNGLSFKGCCSQSDFGTISLKYLDLSFNGVITMSSN-FLGLEQLEHL 340
Query: 310 DLSNNNIASL-RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLS-----RNY 363
D ++N+ + + F L+ L +LD+S V + SL LK++ N+
Sbjct: 341 DFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENF 400
Query: 364 LSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
L + ++T LD+S C+L + + L S+ L++S N
Sbjct: 401 LPDI-FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 443
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 35 FLCRCNLDKTDIDCS--RRGLTDIPNGLG-LQVTKLNISNNEFTKFPESLSRLHNLVNLD 91
FL NL DI + R I NGL L+V K+ ++ + P+ + L NL LD
Sbjct: 356 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD 415
Query: 92 ISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQT 151
+S QL+ L A +L++L+VLN+S N F S L+ P L L++LD S N T
Sbjct: 416 LSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFS-LDTFPYKCL---NSLQVLDYSLNHIMT 471
Score = 48.8 bits (111), Expect = 7e-05
Identities = 96/406 (23%), Positives = 172/406 (42%), Gaps = 36/406 (8%)
Query: 81 LSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLK 140
LS L LV ++ + L+ P + +L L+ LN++ N S+ + T+L+
Sbjct: 38 LSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLIQSF---KLPEYFSNLTNLE 91
Query: 141 ILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNP 200
LDLS NK Q++ + +L + L L LD +N ++ P IR+ KL
Sbjct: 92 HLDLSSNKIQSI-YCTDLRVLHQMPLLNLSLD-LSLNPMNFIQP-GAFKEIRLHKLTLRN 148
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS 260
N++ + ++ L L + L+ L + N S+ L + +
Sbjct: 149 NFDSLNVMKTCIQGL-------AGLEVHRLV----LGEFRNEGNLEKFDKSALEGLCNLT 197
Query: 261 LKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA--FANNTELEYLDLSNNNIAS 318
++ ++Y + + + + + ++V F+ N ++L+L N
Sbjct: 198 IEEFRLAYLDYYLDGIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFG- 256
Query: 319 LRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-----HLRSM 373
++ T + LK LK L + N+ S +++PSL L LSRN LS G ++
Sbjct: 257 -QFPTLK-LKSLKRLTFTSNKGG--NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTI 312
Query: 374 SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDS---ISSNTLKYLNLNYNR 430
S+ LD+S + T+ + L GL+ + LD + L + + +S L YL++++
Sbjct: 313 SLKYLDLSFNGVITMSSNFL-GLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 371
Query: 431 ISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLS 476
N F L+ L L + GN F + F L LDLS
Sbjct: 372 TRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLS 417
Score = 48.8 bits (111), Expect = 7e-05
Identities = 78/281 (27%), Positives = 125/281 (44%), Gaps = 19/281 (6%)
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNL-NPNDVLLPATHLKILD-LSFNKFQTM 152
N L + +L ++T V + S N+ L L N P LK L L+F
Sbjct: 218 NCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NK 275
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLS--GLINIRVLKLNFNPLLRIQN--LI 208
G A E+ + PSLE L L + S G S G I+++ L L+FN ++ + + L
Sbjct: 276 GGNAFSEVDL-PSLEFLDLSRNGL-SFKGCCSQSDFGTISLKYLDLSFNGVITMSSNFLG 333
Query: 209 SSSLRSLFVSNCELTSLNH-NELMFLPSLTHLKMSNNY-RLELASSANNLFS-QSLKYID 265
L L + L ++ + + L +L +L +S+ + R+ N L S + LK
Sbjct: 334 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 393
Query: 266 ISYCNILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD 322
S+ P++ F LR L+ + L AF + + L+ L++S+NN SL
Sbjct: 394 NSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 451
Query: 323 TFRGLKMLKHLDLSWNEIAVIPEDSLLEMP-SLTQLKLSRN 362
++ L L+ LD S N I + L P SL L L++N
Sbjct: 452 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 492
Score = 47.2 bits (107), Expect = 2e-04
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAI---LNHN 290
SL +L +S N + ++S N L + L+++D + N+ Q + F SLR I ++H
Sbjct: 313 SLKYLDLSFNGVITMSS--NFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHT 370
Query: 291 MVRYLESNAFANNTELEYLDLSNNNIA-SLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
R + F + LE L ++ N+ + D F L+ L LDLS ++ + +
Sbjct: 371 HTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 430
Query: 350 EMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGL-QSIVELDLS 405
+ SL L +S N L + S+ +LD S + T K L+ S+ L+L+
Sbjct: 431 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 490
Query: 406 QN 407
QN
Sbjct: 491 QN 492
Score = 42.7 bits (96), Expect = 0.005
Identities = 40/151 (26%), Positives = 71/151 (47%), Gaps = 8/151 (5%)
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNILQPNLK 277
CE+ ++ L L+ L ++ N LA A + S Q L ++ + ++ +
Sbjct: 1 CEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIG 60
Query: 278 GFPSLRKAILNHNMVRYLE-SNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLK----H 332
+L++ + HN+++ + F+N T LE+LDLS+N I S+ R L +
Sbjct: 61 HLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS 120
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY 363
LDLS N + I + E+ L +L L N+
Sbjct: 121 LDLSLNPMNFIQPGAFKEI-RLHKLTLRNNF 150
>BC034389-1|AAH34389.1| 347|Homo sapiens leucine-rich
alpha-2-glycoprotein 1 protein.
Length = 347
Score = 69.3 bits (162), Expect = 5e-11
Identities = 66/257 (25%), Positives = 109/257 (42%), Gaps = 12/257 (4%)
Query: 276 LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
L+G L++ L+ N + L +L LDL+ N + L F+ L L L
Sbjct: 88 LQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQASATLDTLVL 147
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDS 392
N++ V+ L + +L L LS N L ++ G L + + + LD+ +L T+ D
Sbjct: 148 KENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDL 207
Query: 393 LEGLQSIVELDLSQNLLSYIPDS--ISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L G + L L N L + + L+YL LN N+++ + F L +L L +
Sbjct: 208 LRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDL 267
Query: 451 VGNRFTMI----WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEES 506
N + W + + D+S N W C D+N+ D Y ++ + +K
Sbjct: 268 SNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWIC---DQNLSDLYRWLQAQKDKMFSQ 324
Query: 507 FNLICNSPANVNTQTWL 523
+ C P V QT L
Sbjct: 325 NDTRCAGPEAVKGQTLL 341
Score = 62.9 bits (146), Expect = 4e-09
Identities = 56/183 (30%), Positives = 86/183 (46%), Gaps = 4/183 (2%)
Query: 209 SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI-- 266
+S L+ L +S+ L SL+ L +P L L ++ N L S S +L + +
Sbjct: 91 ASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQA-SATLDTLVLKE 149
Query: 267 SYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+ +L+ + L G +L L+ N +R L AN T L LDL N + +L D R
Sbjct: 150 NQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLR 209
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCEL 385
G L+ L L N++ V+ +D LL P L L L+ N L+RV + LDM
Sbjct: 210 GPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSN 269
Query: 386 NTI 388
N++
Sbjct: 270 NSL 272
Score = 58.0 bits (134), Expect = 1e-07
Identities = 53/181 (29%), Positives = 87/181 (48%), Gaps = 9/181 (4%)
Query: 173 HCEINSIHGRSP--LSGLINIRVLKLNFNPLLRIQNLI---SSSLRSLFVSNCELTSLNH 227
H N + SP L + +RVL L N L + + + S++L +L + +L L
Sbjct: 98 HLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEV 157
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQPNL-KGFPSLRK 284
+ L L +L HL +S N +L F+ L+ +D+ + L P+L +G L +
Sbjct: 158 SWLHGLKALGHLDLSGNRLRKLPPGLLANFTL-LRTLDLGENQLETLPPDLLRGPLQLER 216
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIP 344
L N ++ L + +L YL L+ N +A + F+GL+ L LDLS N +A +P
Sbjct: 217 LHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVP 276
Query: 345 E 345
E
Sbjct: 277 E 277
Score = 57.2 bits (132), Expect = 2e-07
Identities = 51/171 (29%), Positives = 79/171 (46%), Gaps = 12/171 (7%)
Query: 46 IDCSRRGLTDIPNGL---GLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLP 101
+D +R LT +P+GL + L + N+ S L L L +LD+S N+L+ LP
Sbjct: 121 LDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP 180
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
L N T L L+L N ++ P D+L L+ L L NK Q +G LL
Sbjct: 181 PGLLANFTLLRTLDLGENQLETL----PPDLLRGPLQLERLHLEGNKLQVLG---KDLLL 233
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
+P L L L+ ++ + GL + +L L+ N L + + +SL
Sbjct: 234 PQPDLRYLFLNGNKLARV-AAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
Score = 46.8 bits (106), Expect = 3e-04
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 6/169 (3%)
Query: 315 NIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-GHLRSM 373
N+ L + +G L+ L LS N + + + L +P L L L+RN L+ + L
Sbjct: 79 NLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQA 138
Query: 374 SVTI--LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYN 429
S T+ L + +L + L GL+++ LDLS N L +P + +N L+ L+L N
Sbjct: 139 SATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGEN 198
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
++ ++ +L L + GN+ ++ + P L L L+ N
Sbjct: 199 QLETLPPDLLRGPLQLERLHLEGNKLQVL-GKDLLLPQPDLRYLFLNGN 246
Score = 37.9 bits (84), Expect = 0.13
Identities = 57/201 (28%), Positives = 86/201 (42%), Gaps = 19/201 (9%)
Query: 53 LTDIPNGL---GLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT +P L ++ +L++S+N PE L + L LD++ N L GLP
Sbjct: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQAS 139
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM--GNLANQELLIRPSL 166
L+ L L N + L ++ L H LDLS N+ + + G LAN L L
Sbjct: 140 ATLDTLVLKENQLEV-LEVSWLHGLKALGH---LDLSGNRLRKLPPGLLANFTL-----L 190
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCELT 223
TL L ++ ++ L G + + L L N L + L LR LF++ +L
Sbjct: 191 RTLDLGENQLETL-PPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLA 249
Query: 224 SLNHNELMFLPSLTHLKMSNN 244
+ L L L +SNN
Sbjct: 250 RVAAGAFQGLRQLDMLDLSNN 270
>AB073607-1|BAD38644.1| 347|Homo sapiens leucine-rich
alpha-2-glycoprotein protein.
Length = 347
Score = 69.3 bits (162), Expect = 5e-11
Identities = 66/257 (25%), Positives = 109/257 (42%), Gaps = 12/257 (4%)
Query: 276 LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
L+G L++ L+ N + L +L LDL+ N + L F+ L L L
Sbjct: 88 LQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQASATLDTLVL 147
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDS 392
N++ V+ L + +L L LS N L ++ G L + + + LD+ +L T+ D
Sbjct: 148 KENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDL 207
Query: 393 LEGLQSIVELDLSQNLLSYIPDS--ISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L G + L L N L + + L+YL LN N+++ + F L +L L +
Sbjct: 208 LRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDL 267
Query: 451 VGNRFTMI----WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEES 506
N + W + + D+S N W C D+N+ D Y ++ + +K
Sbjct: 268 SNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWIC---DQNLSDLYRWLQAQKDKMFSQ 324
Query: 507 FNLICNSPANVNTQTWL 523
+ C P V QT L
Sbjct: 325 NDTRCAGPEAVKGQTLL 341
Score = 62.9 bits (146), Expect = 4e-09
Identities = 56/183 (30%), Positives = 86/183 (46%), Gaps = 4/183 (2%)
Query: 209 SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI-- 266
+S L+ L +S+ L SL+ L +P L L ++ N L S S +L + +
Sbjct: 91 ASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQA-SATLDTLVLKE 149
Query: 267 SYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
+ +L+ + L G +L L+ N +R L AN T L LDL N + +L D R
Sbjct: 150 NQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLR 209
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCEL 385
G L+ L L N++ V+ +D LL P L L L+ N L+RV + LDM
Sbjct: 210 GPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSN 269
Query: 386 NTI 388
N++
Sbjct: 270 NSL 272
Score = 58.0 bits (134), Expect = 1e-07
Identities = 53/181 (29%), Positives = 87/181 (48%), Gaps = 9/181 (4%)
Query: 173 HCEINSIHGRSP--LSGLINIRVLKLNFNPLLRIQNLI---SSSLRSLFVSNCELTSLNH 227
H N + SP L + +RVL L N L + + + S++L +L + +L L
Sbjct: 98 HLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEV 157
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQPNL-KGFPSLRK 284
+ L L +L HL +S N +L F+ L+ +D+ + L P+L +G L +
Sbjct: 158 SWLHGLKALGHLDLSGNRLRKLPPGLLANFTL-LRTLDLGENQLETLPPDLLRGPLQLER 216
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIP 344
L N ++ L + +L YL L+ N +A + F+GL+ L LDLS N +A +P
Sbjct: 217 LHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVP 276
Query: 345 E 345
E
Sbjct: 277 E 277
Score = 57.2 bits (132), Expect = 2e-07
Identities = 51/171 (29%), Positives = 79/171 (46%), Gaps = 12/171 (7%)
Query: 46 IDCSRRGLTDIPNGL---GLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLP 101
+D +R LT +P+GL + L + N+ S L L L +LD+S N+L+ LP
Sbjct: 121 LDLTRNALTGLPSGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP 180
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
L N T L L+L N ++ P D+L L+ L L NK Q +G LL
Sbjct: 181 PGLLANFTLLRTLDLGENQLETL----PPDLLRGPLQLERLHLEGNKLQVLG---KDLLL 233
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
+P L L L+ ++ + GL + +L L+ N L + + +SL
Sbjct: 234 PQPDLRYLFLNGNKLARV-AAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
Score = 46.8 bits (106), Expect = 3e-04
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 6/169 (3%)
Query: 315 NIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV-GHLRSM 373
N+ L + +G L+ L LS N + + + L +P L L L+RN L+ + L
Sbjct: 79 NLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQA 138
Query: 374 SVTI--LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYN 429
S T+ L + +L + L GL+++ LDLS N L +P + +N L+ L+L N
Sbjct: 139 SATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGEN 198
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
++ ++ +L L + GN+ ++ + P L L L+ N
Sbjct: 199 QLETLPPDLLRGPLQLERLHLEGNKLQVL-GKDLLLPQPDLRYLFLNGN 246
Score = 37.9 bits (84), Expect = 0.13
Identities = 57/201 (28%), Positives = 86/201 (42%), Gaps = 19/201 (9%)
Query: 53 LTDIPNGL---GLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT +P L ++ +L++S+N PE L + L LD++ N L GLP
Sbjct: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPSGLFQAS 139
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM--GNLANQELLIRPSL 166
L+ L L N + L ++ L H LDLS N+ + + G LAN L L
Sbjct: 140 ATLDTLVLKENQLEV-LEVSWLHGLKALGH---LDLSGNRLRKLPPGLLANFTL-----L 190
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCELT 223
TL L ++ ++ L G + + L L N L + L LR LF++ +L
Sbjct: 191 RTLDLGENQLETL-PPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLA 249
Query: 224 SLNHNELMFLPSLTHLKMSNN 244
+ L L L +SNN
Sbjct: 250 RVAAGAFQGLRQLDMLDLSNN 270
>BC070198-1|AAH70198.1| 347|Homo sapiens leucine-rich
alpha-2-glycoprotein 1 protein.
Length = 347
Score = 68.9 bits (161), Expect = 6e-11
Identities = 66/257 (25%), Positives = 109/257 (42%), Gaps = 12/257 (4%)
Query: 276 LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
L+G L++ L+ N + L +L LDL+ N + L F+ L L L
Sbjct: 88 LQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVL 147
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDS 392
N++ V+ L + +L L LS N L ++ G L + + + LD+ +L T+ D
Sbjct: 148 KENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDL 207
Query: 393 LEGLQSIVELDLSQNLLSYIPDS--ISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L G + L L N L + + L+YL LN N+++ + F L +L L +
Sbjct: 208 LRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDL 267
Query: 451 VGNRFTMI----WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEES 506
N + W + + D+S N W C D+N+ D Y ++ + +K
Sbjct: 268 SNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWIC---DQNLSDLYRWLQAQKDKMFSQ 324
Query: 507 FNLICNSPANVNTQTWL 523
+ C P V QT L
Sbjct: 325 NDTRCAGPEAVKGQTLL 341
Score = 61.7 bits (143), Expect = 9e-09
Identities = 56/185 (30%), Positives = 84/185 (45%), Gaps = 8/185 (4%)
Query: 209 SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI-- 266
+S L+ L +S+ L SL+ L +P L L ++ N L LF S +
Sbjct: 91 ASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRN---ALTGLPPGLFQASATLDTLVL 147
Query: 267 --SYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+ +L+ + L G +L L+ N +R L AN T L LDL N + +L D
Sbjct: 148 KENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDL 207
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSC 383
RG L+ L L N++ V+ +D LL P L L L+ N L+RV + LDM
Sbjct: 208 LRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDL 267
Query: 384 ELNTI 388
N++
Sbjct: 268 SNNSL 272
Score = 56.8 bits (131), Expect = 3e-07
Identities = 53/181 (29%), Positives = 86/181 (47%), Gaps = 9/181 (4%)
Query: 173 HCEINSIHGRSP--LSGLINIRVLKLNFNPLLRIQNLI---SSSLRSLFVSNCELTSLNH 227
H N + SP L + +RVL L N L + + S++L +L + +L L
Sbjct: 98 HLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEV 157
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQPNL-KGFPSLRK 284
+ L L +L HL +S N +L F+ L+ +D+ + L P+L +G L +
Sbjct: 158 SWLHGLKALGHLDLSGNRLRKLPPGLLANFTL-LRTLDLGENQLETLPPDLLRGPLQLER 216
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIP 344
L N ++ L + +L YL L+ N +A + F+GL+ L LDLS N +A +P
Sbjct: 217 LHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVP 276
Query: 345 E 345
E
Sbjct: 277 E 277
Score = 56.0 bits (129), Expect = 5e-07
Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 12/171 (7%)
Query: 46 IDCSRRGLTDIPNGL---GLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLP 101
+D +R LT +P GL + L + N+ S L L L +LD+S N+L+ LP
Sbjct: 121 LDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP 180
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
L N T L L+L N ++ P D+L L+ L L NK Q +G LL
Sbjct: 181 PGLLANFTLLRTLDLGENQLETL----PPDLLRGPLQLERLHLEGNKLQVLG---KDLLL 233
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
+P L L L+ ++ + GL + +L L+ N L + + +SL
Sbjct: 234 PQPDLRYLFLNGNKLARV-AAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
Score = 46.0 bits (104), Expect = 5e-04
Identities = 44/169 (26%), Positives = 80/169 (47%), Gaps = 6/169 (3%)
Query: 315 NIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLR- 371
N+ L + +G L+ L LS N + + + L +P L L L+RN L+ + G +
Sbjct: 79 NLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQA 138
Query: 372 SMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYN 429
S ++ L + +L + L GL+++ LDLS N L +P + +N L+ L+L N
Sbjct: 139 SATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGEN 198
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
++ ++ +L L + GN+ ++ + P L L L+ N
Sbjct: 199 QLETLPPDLLRGPLQLERLHLEGNKLQVL-GKDLLLPQPDLRYLFLNGN 246
Score = 37.5 bits (83), Expect = 0.17
Identities = 57/201 (28%), Positives = 86/201 (42%), Gaps = 19/201 (9%)
Query: 53 LTDIPNGL---GLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT +P L ++ +L++S+N PE L + L LD++ N L GLP
Sbjct: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM--GNLANQELLIRPSL 166
L+ L L N + L ++ L H LDLS N+ + + G LAN L L
Sbjct: 140 ATLDTLVLKENQLEV-LEVSWLHGLKALGH---LDLSGNRLRKLPPGLLANFTL-----L 190
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCELT 223
TL L ++ ++ L G + + L L N L + L LR LF++ +L
Sbjct: 191 RTLDLGENQLETL-PPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLA 249
Query: 224 SLNHNELMFLPSLTHLKMSNN 244
+ L L L +SNN
Sbjct: 250 RVAAGAFQGLRQLDMLDLSNN 270
>AY358115-1|AAQ88482.1| 593|Homo sapiens DAAT9248 protein.
Length = 593
Score = 68.9 bits (161), Expect = 6e-11
Identities = 86/337 (25%), Positives = 135/337 (40%), Gaps = 16/337 (4%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
+C C + C R L +P GL L L++S N + LSRL L LD+S
Sbjct: 34 VCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSY 93
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
NQL L A + L +L L L N L + V + L +LDL N+ +
Sbjct: 94 NQLSTLEPGAFHGLQSLLTLRLQGNR----LRIMGPGVFSGLSALTLLDLRLNQIVLFLD 149
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
A EL SL+ L + + + +GL + L L L + L + L +
Sbjct: 150 GAFGEL---GSLQKLEVGDNHLVFV-APGAFAGLAKLSTLTLERCNLSTVPGLALARLPA 205
Query: 215 LF---VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI 271
L + ++ L L L L L++ LE A +L +L + I+ CN+
Sbjct: 206 LVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLE-ALDPGSLVGLNLSSLAITRCNL 264
Query: 272 LQPNLKGF---PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ LR L+ N + + + + L+ L LS + S+ F GL
Sbjct: 265 SSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLT 324
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LD++ N + + E + L L+LS N L+
Sbjct: 325 AFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
Score = 52.4 bits (120), Expect = 6e-06
Identities = 52/203 (25%), Positives = 99/203 (48%), Gaps = 8/203 (3%)
Query: 282 LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIA 341
L++ L++N + LE AF L L L N + + F GL L LDL N+I
Sbjct: 86 LQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIV 145
Query: 342 VIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDSLEGLQS 398
+ + + E+ SL +L++ N+L V G ++ ++ L + C L+T+ +L L +
Sbjct: 146 LFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPA 205
Query: 399 IVELDLSQNLLSYIPDSI--SSNTLKYLNLN-YNRISSINNLTFFMLNRLTSLSVVGNRF 455
+V L L + + +P LK L ++ + + +++ + LN L+SL++
Sbjct: 206 LVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLN-LSSLAITRCNL 264
Query: 456 TMIWRRSFFDSNPYLERLDLSDN 478
+ + ++ + + +L LDLS N
Sbjct: 265 SSVPFQALYHLS-FLRVLDLSQN 286
Score = 52.0 bits (119), Expect = 8e-06
Identities = 70/272 (25%), Positives = 116/272 (42%), Gaps = 10/272 (3%)
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCNILQ 273
L +S L L L L L L +S N L A + L S + + I+
Sbjct: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
Query: 274 PNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
P + G +L L N + AF L+ L++ +N++ + F GL L
Sbjct: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSC-ELNTI 388
L L ++ +P +L +P+L L+L + R+ G LR + + L++ L +
Sbjct: 185 LTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEAL 244
Query: 389 GKDSLEGLQSIVELDLSQNLLSYIPDS--ISSNTLKYLNLNYNRISSINNLTFFMLNRLT 446
SL GL ++ L +++ LS +P + L+ L+L+ N IS+I L RL
Sbjct: 245 DPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQ 303
Query: 447 SLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L + G T I +F + LD++DN
Sbjct: 304 ELRLSGACLTSIAAHAFHGLTAF-HLLDVADN 334
Score = 48.4 bits (110), Expect = 9e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 5/161 (3%)
Query: 293 RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP 352
R LE+ + E LDLS N + L+ L +L+ LDLS+N+++ + + +
Sbjct: 49 RQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQ 108
Query: 353 SLTQLKLSRNYLSRVGH--LRSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLL 409
SL L+L N L +G +S +T+LD+ ++ + L S+ +L++ N L
Sbjct: 109 SLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHL 168
Query: 410 SYIPDSISSNTLKYLNLNYNR--ISSINNLTFFMLNRLTSL 448
++ + K L R +S++ L L L +L
Sbjct: 169 VFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVAL 209
>AL589765-16|CAI17178.1| 593|Homo sapiens leucine rich repeat
neuronal 6D protein.
Length = 593
Score = 68.9 bits (161), Expect = 6e-11
Identities = 86/337 (25%), Positives = 135/337 (40%), Gaps = 16/337 (4%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
+C C + C R L +P GL L L++S N + LSRL L LD+S
Sbjct: 34 VCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSY 93
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
NQL L A + L +L L L N L + V + L +LDL N+ +
Sbjct: 94 NQLSTLEPGAFHGLQSLLTLRLQGNR----LRIMGPGVFSGLSALTLLDLRLNQIVLFLD 149
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
A EL SL+ L + + + +GL + L L L + L + L +
Sbjct: 150 GAFGEL---GSLQKLEVGDNHLVFV-APGAFAGLAKLSTLTLERCNLSTVPGLALARLPA 205
Query: 215 LF---VSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI 271
L + ++ L L L L L++ LE A +L +L + I+ CN+
Sbjct: 206 LVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLE-ALDPGSLVGLNLSSLAITRCNL 264
Query: 272 LQPNLKGF---PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ LR L+ N + + + + L+ L LS + S+ F GL
Sbjct: 265 SSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLT 324
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LD++ N + + E + L L+LS N L+
Sbjct: 325 AFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
Score = 52.4 bits (120), Expect = 6e-06
Identities = 52/203 (25%), Positives = 99/203 (48%), Gaps = 8/203 (3%)
Query: 282 LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIA 341
L++ L++N + LE AF L L L N + + F GL L LDL N+I
Sbjct: 86 LQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIV 145
Query: 342 VIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDSLEGLQS 398
+ + + E+ SL +L++ N+L V G ++ ++ L + C L+T+ +L L +
Sbjct: 146 LFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPA 205
Query: 399 IVELDLSQNLLSYIPDSI--SSNTLKYLNLN-YNRISSINNLTFFMLNRLTSLSVVGNRF 455
+V L L + + +P LK L ++ + + +++ + LN L+SL++
Sbjct: 206 LVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLN-LSSLAITRCNL 264
Query: 456 TMIWRRSFFDSNPYLERLDLSDN 478
+ + ++ + + +L LDLS N
Sbjct: 265 SSVPFQALYHLS-FLRVLDLSQN 286
Score = 52.0 bits (119), Expect = 8e-06
Identities = 70/272 (25%), Positives = 116/272 (42%), Gaps = 10/272 (3%)
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFSQSLKYIDISYCNILQ 273
L +S L L L L L L +S N L A + L S + + I+
Sbjct: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
Query: 274 PNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKH 332
P + G +L L N + AF L+ L++ +N++ + F GL L
Sbjct: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184
Query: 333 LDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSC-ELNTI 388
L L ++ +P +L +P+L L+L + R+ G LR + + L++ L +
Sbjct: 185 LTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEAL 244
Query: 389 GKDSLEGLQSIVELDLSQNLLSYIPDS--ISSNTLKYLNLNYNRISSINNLTFFMLNRLT 446
SL GL ++ L +++ LS +P + L+ L+L+ N IS+I L RL
Sbjct: 245 DPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQ 303
Query: 447 SLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L + G T I +F + LD++DN
Sbjct: 304 ELRLSGACLTSIAAHAFHGLTAF-HLLDVADN 334
Score = 48.4 bits (110), Expect = 9e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 5/161 (3%)
Query: 293 RYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMP 352
R LE+ + E LDLS N + L+ L +L+ LDLS+N+++ + + +
Sbjct: 49 RQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQ 108
Query: 353 SLTQLKLSRNYLSRVGH--LRSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLL 409
SL L+L N L +G +S +T+LD+ ++ + L S+ +L++ N L
Sbjct: 109 SLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHL 168
Query: 410 SYIPDSISSNTLKYLNLNYNR--ISSINNLTFFMLNRLTSL 448
++ + K L R +S++ L L L +L
Sbjct: 169 VFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVAL 209
>AL356953-5|CAI15931.1| 232|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 6 protein.
Length = 232
Score = 68.9 bits (161), Expect = 6e-11
Identities = 56/169 (33%), Positives = 85/169 (50%), Gaps = 8/169 (4%)
Query: 290 NMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLL 349
N + L+ F + LE L LS N+++ + F GL LK L L N++ IP ++L
Sbjct: 2 NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALW 61
Query: 350 EMPSLTQLKLSRNYLSRVGHLRSM----SVTILDMSSCELNTIGKDSLEGLQSIVELDLS 405
E+PSL L+L N +S V RS S+ L + L I +L L ++ + L+
Sbjct: 62 ELPSLQSLRLDANLISLVPE-RSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLA 120
Query: 406 QNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVG 452
N +S+IPD N +L L+LNYN++ + L RL LS+ G
Sbjct: 121 LNRISHIPDYAFQNLTSLVVLDLNYNKLQEF-PVAIRTLGRLQELSLNG 168
Score = 53.2 bits (122), Expect = 3e-06
Identities = 68/230 (29%), Positives = 101/230 (43%), Gaps = 15/230 (6%)
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N L L ++L LE L LS N+ L+ P LKIL L N+ +G
Sbjct: 2 NNLTELQPGLFHHLRFLEELRLSGNH----LSHIPGQAFSGLYSLKILMLQNNQ---LGG 54
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
+ + L PSL++L LD I+ + RS GL ++R L L+ N L I ++L +
Sbjct: 55 IPAEALWELPSLQSLRLDANLISLVPERS-FEGLSSLRHLWLDDNALTEIPVRALNNLPA 113
Query: 215 LFVSNCELTSLNH-NELMF--LPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI 271
L L ++H + F L SL L ++ N E + L L+ + ++
Sbjct: 114 LQAMTLALNRISHIPDYAFQNLTSLVVLDLNYNKLQEFPVAIRTL--GRLQELSLNGAMD 171
Query: 272 LQ--PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
+Q P+LKG SL L +R L S L L+LS+N I L
Sbjct: 172 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 221
Score = 53.2 bits (122), Expect = 3e-06
Identities = 47/161 (29%), Positives = 75/161 (46%), Gaps = 5/161 (3%)
Query: 272 LQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
LQP L L + L+ N + ++ AF+ L+ L L NN + + + L L
Sbjct: 7 LQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSL 66
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIG- 389
+ L L N I+++PE S + SL L L N L+ + ++ L + LN I
Sbjct: 67 QSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISH 126
Query: 390 --KDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLN 427
+ + L S+V LDL+ N L P +I + L+ L+LN
Sbjct: 127 IPDYAFQNLTSLVVLDLNYNKLQEFPVAIRTLGRLQELSLN 167
Score = 48.8 bits (111), Expect = 7e-05
Identities = 45/180 (25%), Positives = 82/180 (45%), Gaps = 3/180 (1%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G SL+ +L +N + + + A L+ L L N I+ + +F GL L+HL L
Sbjct: 38 GLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDD 97
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGK--DSLEG 395
N + IP +L +P+L + L+ N +S + ++T L + N + + ++
Sbjct: 98 NALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLDLNYNKLQEFPVAIRT 157
Query: 396 LQSIVELDLSQNL-LSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNR 454
L + EL L+ + + PD + +L+ L L I + + L RL L + N+
Sbjct: 158 LGRLQELSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 217
Score = 42.3 bits (95), Expect = 0.006
Identities = 40/137 (29%), Positives = 66/137 (48%), Gaps = 9/137 (6%)
Query: 66 KLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L +S N + P ++ S L++L L + +NQL G+P AL+ L +L+ L L N
Sbjct: 20 ELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANL---- 75
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
++L P + L+ L L N + A L P+L+ + L I+ I +
Sbjct: 76 ISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL---PALQAMTLALNRISHIPDYA- 131
Query: 185 LSGLINIRVLKLNFNPL 201
L ++ VL LN+N L
Sbjct: 132 FQNLTSLVVLDLNYNKL 148
>AF403428-1|AAK95527.1| 347|Homo sapiens leucine-rich
alpha-2-glycoprotein protein.
Length = 347
Score = 68.9 bits (161), Expect = 6e-11
Identities = 66/257 (25%), Positives = 109/257 (42%), Gaps = 12/257 (4%)
Query: 276 LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
L+G L++ L+ N + L +L LDL+ N + L F+ L L L
Sbjct: 88 LQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVL 147
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMSSCELNTIGKDS 392
N++ V+ L + +L L LS N L ++ G L + + + LD+ +L T+ D
Sbjct: 148 KENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDL 207
Query: 393 LEGLQSIVELDLSQNLLSYIPDS--ISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L G + L L N L + + L+YL LN N+++ + F L +L L +
Sbjct: 208 LRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDL 267
Query: 451 VGNRFTMI----WRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEES 506
N + W + + D+S N W C D+N+ D Y ++ + +K
Sbjct: 268 SNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWIC---DQNLSDLYRWLQAQKDKMFSQ 324
Query: 507 FNLICNSPANVNTQTWL 523
+ C P V QT L
Sbjct: 325 NDTRCAGPEAVKGQTLL 341
Score = 61.7 bits (143), Expect = 9e-09
Identities = 56/185 (30%), Positives = 84/185 (45%), Gaps = 8/185 (4%)
Query: 209 SSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI-- 266
+S L+ L +S+ L SL+ L +P L L ++ N L LF S +
Sbjct: 91 ASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRN---ALTGLPPGLFQASATLDTLVL 147
Query: 267 --SYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+ +L+ + L G +L L+ N +R L AN T L LDL N + +L D
Sbjct: 148 KENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDL 207
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSC 383
RG L+ L L N++ V+ +D LL P L L L+ N L+RV + LDM
Sbjct: 208 LRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDL 267
Query: 384 ELNTI 388
N++
Sbjct: 268 SNNSL 272
Score = 56.8 bits (131), Expect = 3e-07
Identities = 53/181 (29%), Positives = 86/181 (47%), Gaps = 9/181 (4%)
Query: 173 HCEINSIHGRSP--LSGLINIRVLKLNFNPLLRIQNLI---SSSLRSLFVSNCELTSLNH 227
H N + SP L + +RVL L N L + + S++L +L + +L L
Sbjct: 98 HLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEV 157
Query: 228 NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDI--SYCNILQPNL-KGFPSLRK 284
+ L L +L HL +S N +L F+ L+ +D+ + L P+L +G L +
Sbjct: 158 SWLHGLKALGHLDLSGNRLRKLPPGLLANFTL-LRTLDLGENQLETLPPDLLRGPLQLER 216
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIP 344
L N ++ L + +L YL L+ N +A + F+GL+ L LDLS N +A +P
Sbjct: 217 LHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVP 276
Query: 345 E 345
E
Sbjct: 277 E 277
Score = 56.0 bits (129), Expect = 5e-07
Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 12/171 (7%)
Query: 46 IDCSRRGLTDIPNGL---GLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGLP 101
+D +R LT +P GL + L + N+ S L L L +LD+S N+L+ LP
Sbjct: 121 LDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLP 180
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELL 161
L N T L L+L N ++ P D+L L+ L L NK Q +G LL
Sbjct: 181 PGLLANFTLLRTLDLGENQLETL----PPDLLRGPLQLERLHLEGNKLQVLG---KDLLL 233
Query: 162 IRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
+P L L L+ ++ + GL + +L L+ N L + + +SL
Sbjct: 234 PQPDLRYLFLNGNKLARV-AAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
Score = 46.0 bits (104), Expect = 5e-04
Identities = 44/169 (26%), Positives = 80/169 (47%), Gaps = 6/169 (3%)
Query: 315 NIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLR- 371
N+ L + +G L+ L LS N + + + L +P L L L+RN L+ + G +
Sbjct: 79 NLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQA 138
Query: 372 SMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYN 429
S ++ L + +L + L GL+++ LDLS N L +P + +N L+ L+L N
Sbjct: 139 SATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGEN 198
Query: 430 RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
++ ++ +L L + GN+ ++ + P L L L+ N
Sbjct: 199 QLETLPPDLLRGPLQLERLHLEGNKLQVL-GKDLLLPQPDLRYLFLNGN 246
Score = 37.5 bits (83), Expect = 0.17
Identities = 57/201 (28%), Positives = 86/201 (42%), Gaps = 19/201 (9%)
Query: 53 LTDIPNGL---GLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNL 108
LT +P L ++ +L++S+N PE L + L LD++ N L GLP
Sbjct: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
Query: 109 TALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM--GNLANQELLIRPSL 166
L+ L L N + L ++ L H LDLS N+ + + G LAN L L
Sbjct: 140 ATLDTLVLKENQLEV-LEVSWLHGLKALGH---LDLSGNRLRKLPPGLLANFTL-----L 190
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCELT 223
TL L ++ ++ L G + + L L N L + L LR LF++ +L
Sbjct: 191 RTLDLGENQLETL-PPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLA 249
Query: 224 SLNHNELMFLPSLTHLKMSNN 244
+ L L L +SNN
Sbjct: 250 RVAAGAFQGLRQLDMLDLSNN 270
>D63481-1|BAA09768.3| 1630|Homo sapiens KIAA0147 protein protein.
Length = 1630
Score = 68.5 bits (160), Expect = 8e-11
Identities = 85/283 (30%), Positives = 132/283 (46%), Gaps = 29/283 (10%)
Query: 166 LETLILDHCEINSI------HGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSN 219
+E++ HC + ++ + RS L++ L+ P R+ NL R L +S+
Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNL-----RKLGLSD 68
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF 279
E+ L F+ L L +S N E+ S F ++L+ D S N L GF
Sbjct: 69 NEIQRLPPEVANFM-QLVELDVSRNDIPEIPESIK--FCKALEIADFSG-NPLSRLPDGF 124
Query: 280 PSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
LR LN ++ L + N L L+L N + SL + L L+ LDL
Sbjct: 125 TQLRSLAHLALNDVSLQALPGDV-GNLANLVTLELRENLLKSLPA-SLSFLVKLEQLDLG 182
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLS----RVGHLRSMSVTILDMSSCELNTIGKDS 392
N++ V+P D+L +P+L +L L RN LS +G+LR + LD+S L + +
Sbjct: 183 GNDLEVLP-DTLGALPNLRELWLDRNQLSALPPELGNLRRL--VCLDVSENRLEELPAE- 238
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSI 434
L GL + +L LSQNLL +PD I L L ++ NR+ +
Sbjct: 239 LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV 281
Score = 58.4 bits (135), Expect = 9e-08
Identities = 88/322 (27%), Positives = 144/322 (44%), Gaps = 29/322 (9%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF 121
L + KL +S+NE + P ++ LV LD+S N + +P++ + ALE+ + S N
Sbjct: 59 LNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKF-CKALEIADFSGNP- 116
Query: 122 DSWLNLNPNDV--LLPATHLKILDLSFNKFQ-TMGNLAN------QELLIR---PSLETL 169
L+ P+ L HL + D+S +GNLAN +E L++ SL L
Sbjct: 117 ---LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFL 173
Query: 170 I-LDHCEI--NSIHG-RSPLSGLINIRVLKLNFNPLLRIQNLISSSLR--SLFVSNCELT 223
+ L+ ++ N + L L N+R L L+ N L + + + R L VS L
Sbjct: 174 VKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLE 233
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS-YCNILQPNLKGFPSL 282
L EL L LT L +S N L L S+ +D + C + + + +L
Sbjct: 234 EL-PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA-IGDCENL 291
Query: 283 RKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAV 342
+ IL N++ L + T+L L++ N++ +L + G L L L N +AV
Sbjct: 292 SELILTENLLMAL-PRSLGKLTKLTNLNVDRNHLEALPPE-IGGCVALSVLSLRDNRLAV 349
Query: 343 IPEDSLLEMPSLTQLKLSRNYL 364
+P + L L L ++ N L
Sbjct: 350 LPPE-LAHTTELHVLDVAGNRL 370
Score = 54.4 bits (125), Expect = 1e-06
Identities = 75/302 (24%), Positives = 129/302 (42%), Gaps = 18/302 (5%)
Query: 45 DIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPD 102
++D SR + +IP + + + S N ++ P+ ++L +L +L ++ L+ LP
Sbjct: 86 ELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 145
Query: 103 NA--LYNLTALEVL-NLSRNYFDSWLNLNPNDVL-LPATHLKILDLSFNKFQTMGNL--- 155
+ L NL LE+ NL ++ S L + L L L++L + + L
Sbjct: 146 DVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
Query: 156 ANQELLIRPSLETL----ILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSS 211
NQ + P L L LD E + L GL+ + L L+ N L R+ + I
Sbjct: 206 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ- 264
Query: 212 LRSLFVSNCELTSLNH--NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + L + +L+ L ++ N + L S L + +D ++
Sbjct: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Query: 270 NILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD-TFRGLK 328
L P + G +L L N + L A+ TEL LD++ N + SL + T LK
Sbjct: 325 EALPPEIGGCVALSVLSLRDNRLAVLPPE-LAHTTELHVLDVAGNRLQSLPFALTHLNLK 383
Query: 329 ML 330
L
Sbjct: 384 AL 385
Score = 33.1 bits (72), Expect = 3.7
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 4/90 (4%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T+++ R L +P +G + ++ L++ +N P L+ L LD++ N+L+ LP
Sbjct: 315 TNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPND 131
AL +L L+ L L+ N L D
Sbjct: 375 -FALTHLN-LKALWLAENQAQPMLRFQTED 402
>BC052210-1|AAH52210.2| 552|Homo sapiens LRRC32 protein protein.
Length = 552
Score = 68.5 bits (160), Expect = 8e-11
Identities = 82/273 (30%), Positives = 132/273 (48%), Gaps = 27/273 (9%)
Query: 84 LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILD 143
L L+NLD+S N+++ +PD+ L +LT+L LNLSRN ++ LP L +LD
Sbjct: 204 LSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGS--LPC--LMLLD 259
Query: 144 LSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFN---- 199
LS N +T+ L + L SL TL+L + + + + L +++ L L N
Sbjct: 260 LSHNALETL-ELGARAL---GSLRTLLLQGNALRDLPPYT-FANLASLQRLNLQGNRVSP 314
Query: 200 --------PLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELAS 251
P + +SLRSL + + E+ L + P LT L +S+N LE+A+
Sbjct: 315 CGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVAT 373
Query: 252 SANNLFSQSLKYIDI--SYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYL 309
A SL+ + + + +LQ +L F L++ L N + +L A+ LE L
Sbjct: 374 GALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVL 431
Query: 310 DLSNNNIASLRYDTFRGLK-MLKHLDLSWNEIA 341
DL NN+ + L GL+ L+ L L N ++
Sbjct: 432 DLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLS 464
Score = 67.3 bits (157), Expect = 2e-10
Identities = 102/367 (27%), Positives = 154/367 (41%), Gaps = 35/367 (9%)
Query: 135 PATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVL 194
P + LDLS N + L + L PSL TL L + + R + + L
Sbjct: 12 PLPRVTSLDLSGNSLYS--GLLERLLGEAPSLHTLSLAENSLTRLT-RHTFRDMPALEQL 68
Query: 195 KLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSAN 254
L+ N L+ I++ L L N SL L L L +S N +++
Sbjct: 69 DLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQ 128
Query: 255 NLFSQSLKYIDISYCNILQ-PNLKGFPSLRKAILNHNMVRYL------ESNAFANNTELE 307
L ++D+ +L P+L P L L++N++R A +
Sbjct: 129 PQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS 188
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL--- 364
L LS A + R L L +LDLS+NEI +IP+ L + SL L LSRN L
Sbjct: 189 ALPLS----APSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTF 244
Query: 365 --SRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--T 420
R+G L + + L ++ E +G +L L++++ L N L +P +N +
Sbjct: 245 EARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLL---LQGNALRDLPPYTFANLAS 301
Query: 421 LKYLNLNYNRISSINN---------LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLE 471
L+ LNL NR+S + F + L SLS+V N ++ R F P L
Sbjct: 302 LQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELL-RAGAFLHTP-LT 359
Query: 472 RLDLSDN 478
LDLS N
Sbjct: 360 ELDLSSN 366
Score = 56.0 bits (129), Expect = 5e-07
Identities = 113/399 (28%), Positives = 169/399 (42%), Gaps = 36/399 (9%)
Query: 67 LNISNNEFTKFPESLSR-LHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD--S 123
L+++ N T+ R + L LD+ SN L + D A L L LNLSRN S
Sbjct: 44 LSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCIS 103
Query: 124 WLNLNPNDVL-LPATHLKILDLSFN---KFQ-TMGNLANQELLIRP---SLETLILDHCE 175
+L VL L ++ + +FQ T +L +LL P +L LI +
Sbjct: 104 DFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLS 163
Query: 176 INSIH-GRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLF-VSNCELTSLNHNELM-- 231
N I P I ++ L ++S R L + N +L S N EL+
Sbjct: 164 NNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDL-SYNEIELIPD 222
Query: 232 -FLPSLTHLKMSNNYRLELAS-SANNLFS-QSLKYIDISY--CNILQPNLKGFPSLRKAI 286
FL LT L N R L + A L S L +D+S+ L+ + SLR +
Sbjct: 223 SFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLL 282
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD---------TFRGLKMLKHLDLSW 337
L N +R L FAN L+ L+L N ++ F G+ L+ L L
Sbjct: 283 LQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVD 342
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM--SVTILDMSSCELNTIGKDSL 393
NEI ++ + L P LT+L LS N V G L + S+ +L + L + D L
Sbjct: 343 NEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD-L 400
Query: 394 EGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRIS 432
+ L+L++N LS++P + +L+ L+L N S
Sbjct: 401 PCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFS 439
>AY062238-1|AAL38976.1| 1630|Homo sapiens scribble protein.
Length = 1630
Score = 68.5 bits (160), Expect = 8e-11
Identities = 85/283 (30%), Positives = 132/283 (46%), Gaps = 29/283 (10%)
Query: 166 LETLILDHCEINSI------HGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSN 219
+E++ HC + ++ + RS L++ L+ P R+ NL R L +S+
Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNL-----RKLGLSD 68
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF 279
E+ L F+ L L +S N E+ S F ++L+ D S N L GF
Sbjct: 69 NEIQRLPPEVANFM-QLVELDVSRNDIPEIPESIK--FCKALEIADFSG-NPLSRLPDGF 124
Query: 280 PSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
LR LN ++ L + N L L+L N + SL + L L+ LDL
Sbjct: 125 TQLRSLAHLALNDVSLQALPGDV-GNLANLVTLELRENLLKSLPA-SLSFLVKLEQLDLG 182
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLS----RVGHLRSMSVTILDMSSCELNTIGKDS 392
N++ V+P D+L +P+L +L L RN LS +G+LR + LD+S L + +
Sbjct: 183 GNDLEVLP-DTLGALPNLRELWLDRNQLSALPPELGNLRRL--VCLDVSENRLEELPAE- 238
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSI 434
L GL + +L LSQNLL +PD I L L ++ NR+ +
Sbjct: 239 LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV 281
Score = 58.4 bits (135), Expect = 9e-08
Identities = 88/322 (27%), Positives = 144/322 (44%), Gaps = 29/322 (9%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF 121
L + KL +S+NE + P ++ LV LD+S N + +P++ + ALE+ + S N
Sbjct: 59 LNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKF-CKALEIADFSGNP- 116
Query: 122 DSWLNLNPNDV--LLPATHLKILDLSFNKFQ-TMGNLAN------QELLIR---PSLETL 169
L+ P+ L HL + D+S +GNLAN +E L++ SL L
Sbjct: 117 ---LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFL 173
Query: 170 I-LDHCEI--NSIHG-RSPLSGLINIRVLKLNFNPLLRIQNLISSSLR--SLFVSNCELT 223
+ L+ ++ N + L L N+R L L+ N L + + + R L VS L
Sbjct: 174 VKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLE 233
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS-YCNILQPNLKGFPSL 282
L EL L LT L +S N L L S+ +D + C + + + +L
Sbjct: 234 EL-PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA-IGDCENL 291
Query: 283 RKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAV 342
+ IL N++ L + T+L L++ N++ +L + G L L L N +AV
Sbjct: 292 SELILTENLLMAL-PRSLGKLTKLTNLNVDRNHLEALPPE-IGGCVALSVLSLRDNRLAV 349
Query: 343 IPEDSLLEMPSLTQLKLSRNYL 364
+P + L L L ++ N L
Sbjct: 350 LPPE-LAHTTELHVLDVAGNRL 370
Score = 54.4 bits (125), Expect = 1e-06
Identities = 75/302 (24%), Positives = 129/302 (42%), Gaps = 18/302 (5%)
Query: 45 DIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPD 102
++D SR + +IP + + + S N ++ P+ ++L +L +L ++ L+ LP
Sbjct: 86 ELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 145
Query: 103 NA--LYNLTALEVL-NLSRNYFDSWLNLNPNDVL-LPATHLKILDLSFNKFQTMGNL--- 155
+ L NL LE+ NL ++ S L + L L L++L + + L
Sbjct: 146 DVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
Query: 156 ANQELLIRPSLETL----ILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSS 211
NQ + P L L LD E + L GL+ + L L+ N L R+ + I
Sbjct: 206 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ- 264
Query: 212 LRSLFVSNCELTSLNH--NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + L + +L+ L ++ N + L S L + +D ++
Sbjct: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Query: 270 NILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD-TFRGLK 328
L P + G +L L N + L A+ TEL LD++ N + SL + T LK
Sbjct: 325 EALPPEIGGCVALSVLSLRDNRLAVLPPE-LAHTTELHVLDVAGNRLQSLPFALTHLNLK 383
Query: 329 ML 330
L
Sbjct: 384 AL 385
Score = 33.1 bits (72), Expect = 3.7
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 4/90 (4%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T+++ R L +P +G + ++ L++ +N P L+ L LD++ N+L+ LP
Sbjct: 315 TNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPND 131
AL +L L+ L L+ N L D
Sbjct: 375 -FALTHLN-LKALWLAENQAQPMLRFQTED 402
>AL159161-1|CAI17102.1| 754|Homo sapiens relaxin/insulin-like
family peptide receptor 2 protein.
Length = 754
Score = 68.5 bits (160), Expect = 8e-11
Identities = 48/178 (26%), Positives = 86/178 (48%), Gaps = 5/178 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G +L+ LNHN + L F + +L +L L +N I + F GL L L +
Sbjct: 183 GLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVN 242
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLE 394
N + +P+ +MP L + L N YL+ L S+T+L + ++ + + +
Sbjct: 243 NYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFS 302
Query: 395 GLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L+++ ELDLS N ++ + + + L+ LNL+ N + ++ F L +L SL +
Sbjct: 303 SLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
Score = 65.3 bits (152), Expect = 8e-10
Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 6/202 (2%)
Query: 279 FPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+ L+K L HN +R++ AF L+ L L++N I +LR F+ L L L L N
Sbjct: 160 YTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDN 219
Query: 339 EIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH---LRSMSVTILDMSSCELNTIGKDSLEG 395
I I + + SL L + NYL + + + +D+ + + +
Sbjct: 220 PITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLS 279
Query: 396 LQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
S+ L L +N + ++P+ S+ L L+L+ N I+ ++ F L L L++ N
Sbjct: 280 CDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSN 339
Query: 454 RFTMIWRRSFFDSNPYLERLDL 475
M ++ F+S L+ LDL
Sbjct: 340 PL-MYLHKNQFESLKQLQSLDL 360
Score = 64.9 bits (151), Expect = 1e-09
Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 11/243 (4%)
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
+N + V + + ++ +L L NK + L ++ + L+ + L H I I R
Sbjct: 125 VNGDLKSVPMISNNVTLLSLKKNKIHS---LPDKVFIKYTKLKKIFLQHNCIRHI-SRKA 180
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISSSLRSL---FVSNCELTSLNHNELMFLPSLTHLKM 241
GL N+++L LN N + ++ I L L + + +T ++ L SL L M
Sbjct: 181 FFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSM 240
Query: 242 SNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF---PSLRKAILNHNMVRYLESN 298
NNY LE L ++D+ I F SL L N + ++
Sbjct: 241 VNNY-LEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEK 299
Query: 299 AFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLK 358
F++ L LDLS+N I L F+ LK+L+ L+LS N + + ++ + L L
Sbjct: 300 TFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLD 359
Query: 359 LSR 361
L R
Sbjct: 360 LER 362
Score = 53.6 bits (123), Expect = 2e-06
Identities = 66/250 (26%), Positives = 109/250 (43%), Gaps = 12/250 (4%)
Query: 129 PNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGL 188
P+ V + T LK + L N + + A L +L+ L L+H I ++ L
Sbjct: 153 PDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLC---NLQILYLNHNCITTLRP-GIFKDL 208
Query: 189 INIRVLKLNFNPLLRIQNLISSSLRSLF---VSNCELTSLNHNELMFLPSLTHLKMSNNY 245
+ L L+ NP+ RI + + L SLF + N L +L +P L + + N
Sbjct: 209 HQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGN- 267
Query: 246 RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLR---KAILNHNMVRYLESNAFAN 302
R++ +++ L SL + + I K F SL+ + L+ N + L + F +
Sbjct: 268 RIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKD 327
Query: 303 NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR- 361
L+ L+LS+N + L + F LK L+ LDL EI I M +L+ +
Sbjct: 328 LKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNF 387
Query: 362 NYLSRVGHLR 371
Y S H+R
Sbjct: 388 RYCSYAPHVR 397
Score = 50.0 bits (114), Expect = 3e-05
Identities = 72/289 (24%), Positives = 122/289 (42%), Gaps = 22/289 (7%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALE 112
L P + T+L N + P +S +N+ L + N++ LPD T L+
Sbjct: 108 LKQYPQCCDCKETELECVNGDLKSVP-MIS--NNVTLLSLKKNKIHSLPDKVFIKYTKLK 164
Query: 113 VLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD 172
+ L N + +L+IL L+ N T+ ++L L LILD
Sbjct: 165 KIFLQHNC----IRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDL---HQLTWLILD 217
Query: 173 HCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE---LTSLNHNE 229
I I R +GL ++ L + N L + + + + L + E + L ++
Sbjct: 218 DNPITRISQRL-FTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNST 276
Query: 230 LMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNI--LQPNL-KGFPSLRK 284
+ SLT L + N ++ FS ++L +D+S I L P+L K L+K
Sbjct: 277 FLSCDSLTVLFLPRN---QIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L+ N + YL N F + +L+ LDL I ++ F+ +K L H+
Sbjct: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHI 382
Score = 50.0 bits (114), Expect = 3e-05
Identities = 54/225 (24%), Positives = 97/225 (43%), Gaps = 8/225 (3%)
Query: 190 NIRVLKLNFNPLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYR 246
N+ +L L N + + + + + L+ +F+ + + ++ L +L L +++N
Sbjct: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
Query: 247 LELASSANNLFSQSLKYI--DISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNT 304
L Q I D I Q G SL + +N + L A
Sbjct: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
+L ++DL N I L TF L L L N+I +PE + + +L +L LS N +
Sbjct: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTI 317
Query: 365 SRVG-HL-RSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQ 406
+ + HL + + + L++SS L + K+ E L+ + LDL +
Sbjct: 318 TELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLER 362
>AL138708-1|CAH73785.1| 754|Homo sapiens relaxin/insulin-like
family peptide receptor 2 protein.
Length = 754
Score = 68.5 bits (160), Expect = 8e-11
Identities = 48/178 (26%), Positives = 86/178 (48%), Gaps = 5/178 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G +L+ LNHN + L F + +L +L L +N I + F GL L L +
Sbjct: 183 GLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVN 242
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLE 394
N + +P+ +MP L + L N YL+ L S+T+L + ++ + + +
Sbjct: 243 NYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFS 302
Query: 395 GLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L+++ ELDLS N ++ + + + L+ LNL+ N + ++ F L +L SL +
Sbjct: 303 SLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
Score = 65.3 bits (152), Expect = 8e-10
Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 6/202 (2%)
Query: 279 FPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+ L+K L HN +R++ AF L+ L L++N I +LR F+ L L L L N
Sbjct: 160 YTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDN 219
Query: 339 EIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH---LRSMSVTILDMSSCELNTIGKDSLEG 395
I I + + SL L + NYL + + + +D+ + + +
Sbjct: 220 PITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLS 279
Query: 396 LQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
S+ L L +N + ++P+ S+ L L+L+ N I+ ++ F L L L++ N
Sbjct: 280 CDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSN 339
Query: 454 RFTMIWRRSFFDSNPYLERLDL 475
M ++ F+S L+ LDL
Sbjct: 340 PL-MYLHKNQFESLKQLQSLDL 360
Score = 64.9 bits (151), Expect = 1e-09
Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 11/243 (4%)
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
+N + V + + ++ +L L NK + L ++ + L+ + L H I I R
Sbjct: 125 VNGDLKSVPMISNNVTLLSLKKNKIHS---LPDKVFIKYTKLKKIFLQHNCIRHI-SRKA 180
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISSSLRSL---FVSNCELTSLNHNELMFLPSLTHLKM 241
GL N+++L LN N + ++ I L L + + +T ++ L SL L M
Sbjct: 181 FFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSM 240
Query: 242 SNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF---PSLRKAILNHNMVRYLESN 298
NNY LE L ++D+ I F SL L N + ++
Sbjct: 241 VNNY-LEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEK 299
Query: 299 AFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLK 358
F++ L LDLS+N I L F+ LK+L+ L+LS N + + ++ + L L
Sbjct: 300 TFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLD 359
Query: 359 LSR 361
L R
Sbjct: 360 LER 362
Score = 53.6 bits (123), Expect = 2e-06
Identities = 66/250 (26%), Positives = 109/250 (43%), Gaps = 12/250 (4%)
Query: 129 PNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGL 188
P+ V + T LK + L N + + A L +L+ L L+H I ++ L
Sbjct: 153 PDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLC---NLQILYLNHNCITTLRP-GIFKDL 208
Query: 189 INIRVLKLNFNPLLRIQNLISSSLRSLF---VSNCELTSLNHNELMFLPSLTHLKMSNNY 245
+ L L+ NP+ RI + + L SLF + N L +L +P L + + N
Sbjct: 209 HQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGN- 267
Query: 246 RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLR---KAILNHNMVRYLESNAFAN 302
R++ +++ L SL + + I K F SL+ + L+ N + L + F +
Sbjct: 268 RIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKD 327
Query: 303 NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR- 361
L+ L+LS+N + L + F LK L+ LDL EI I M +L+ +
Sbjct: 328 LKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNF 387
Query: 362 NYLSRVGHLR 371
Y S H+R
Sbjct: 388 RYCSYAPHVR 397
Score = 50.0 bits (114), Expect = 3e-05
Identities = 72/289 (24%), Positives = 122/289 (42%), Gaps = 22/289 (7%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALE 112
L P + T+L N + P +S +N+ L + N++ LPD T L+
Sbjct: 108 LKQYPQCCDCKETELECVNGDLKSVP-MIS--NNVTLLSLKKNKIHSLPDKVFIKYTKLK 164
Query: 113 VLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD 172
+ L N + +L+IL L+ N T+ ++L L LILD
Sbjct: 165 KIFLQHNC----IRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDL---HQLTWLILD 217
Query: 173 HCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE---LTSLNHNE 229
I I R +GL ++ L + N L + + + + L + E + L ++
Sbjct: 218 DNPITRISQRL-FTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNST 276
Query: 230 LMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNI--LQPNL-KGFPSLRK 284
+ SLT L + N ++ FS ++L +D+S I L P+L K L+K
Sbjct: 277 FLSCDSLTVLFLPRN---QIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L+ N + YL N F + +L+ LDL I ++ F+ +K L H+
Sbjct: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHI 382
Score = 50.0 bits (114), Expect = 3e-05
Identities = 54/225 (24%), Positives = 97/225 (43%), Gaps = 8/225 (3%)
Query: 190 NIRVLKLNFNPLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYR 246
N+ +L L N + + + + + L+ +F+ + + ++ L +L L +++N
Sbjct: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
Query: 247 LELASSANNLFSQSLKYI--DISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNT 304
L Q I D I Q G SL + +N + L A
Sbjct: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
+L ++DL N I L TF L L L N+I +PE + + +L +L LS N +
Sbjct: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTI 317
Query: 365 SRVG-HL-RSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQ 406
+ + HL + + + L++SS L + K+ E L+ + LDL +
Sbjct: 318 TELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLER 362
>AF453828-1|AAL73946.1| 754|Homo sapiens G protein-coupled receptor
affecting testicular descent protein.
Length = 754
Score = 68.5 bits (160), Expect = 8e-11
Identities = 48/178 (26%), Positives = 86/178 (48%), Gaps = 5/178 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G +L+ LNHN + L F + +L +L L +N I + F GL L L +
Sbjct: 183 GLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVN 242
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLE 394
N + +P+ +MP L + L N YL+ L S+T+L + ++ + + +
Sbjct: 243 NYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFS 302
Query: 395 GLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L+++ ELDLS N ++ + + + L+ LNL+ N + ++ F L +L SL +
Sbjct: 303 SLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
Score = 65.3 bits (152), Expect = 8e-10
Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 6/202 (2%)
Query: 279 FPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+ L+K L HN +R++ AF L+ L L++N I +LR F+ L L L L N
Sbjct: 160 YTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDN 219
Query: 339 EIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH---LRSMSVTILDMSSCELNTIGKDSLEG 395
I I + + SL L + NYL + + + +D+ + + +
Sbjct: 220 PITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLS 279
Query: 396 LQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
S+ L L +N + ++P+ S+ L L+L+ N I+ ++ F L L L++ N
Sbjct: 280 CDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSN 339
Query: 454 RFTMIWRRSFFDSNPYLERLDL 475
M ++ F+S L+ LDL
Sbjct: 340 PL-MYLHKNQFESLKQLQSLDL 360
Score = 64.9 bits (151), Expect = 1e-09
Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 11/243 (4%)
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
+N + V + + ++ +L L NK + L ++ + L+ + L H I I R
Sbjct: 125 VNGDLKSVPMISNNVTLLSLKKNKIHS---LPDKVFIKYTKLKKIFLQHNCIRHI-SRKA 180
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISSSLRSL---FVSNCELTSLNHNELMFLPSLTHLKM 241
GL N+++L LN N + ++ I L L + + +T ++ L SL L M
Sbjct: 181 FFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSM 240
Query: 242 SNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF---PSLRKAILNHNMVRYLESN 298
NNY LE L ++D+ I F SL L N + ++
Sbjct: 241 VNNY-LEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEK 299
Query: 299 AFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLK 358
F++ L LDLS+N I L F+ LK+L+ L+LS N + + ++ + L L
Sbjct: 300 TFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLD 359
Query: 359 LSR 361
L R
Sbjct: 360 LER 362
Score = 53.6 bits (123), Expect = 2e-06
Identities = 66/250 (26%), Positives = 109/250 (43%), Gaps = 12/250 (4%)
Query: 129 PNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGL 188
P+ V + T LK + L N + + A L +L+ L L+H I ++ L
Sbjct: 153 PDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLC---NLQILYLNHNCITTLRP-GIFKDL 208
Query: 189 INIRVLKLNFNPLLRIQNLISSSLRSLF---VSNCELTSLNHNELMFLPSLTHLKMSNNY 245
+ L L+ NP+ RI + + L SLF + N L +L +P L + + N
Sbjct: 209 HQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGN- 267
Query: 246 RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLR---KAILNHNMVRYLESNAFAN 302
R++ +++ L SL + + I K F SL+ + L+ N + L + F +
Sbjct: 268 RIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKD 327
Query: 303 NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR- 361
L+ L+LS+N + L + F LK L+ LDL EI I M +L+ +
Sbjct: 328 LKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNF 387
Query: 362 NYLSRVGHLR 371
Y S H+R
Sbjct: 388 RYCSYAPHVR 397
Score = 50.0 bits (114), Expect = 3e-05
Identities = 72/289 (24%), Positives = 122/289 (42%), Gaps = 22/289 (7%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALE 112
L P + T+L N + P +S +N+ L + N++ LPD T L+
Sbjct: 108 LKQYPQCCDCKETELECVNGDLKSVP-MIS--NNVTLLSLKKNKIHSLPDKVFIKYTKLK 164
Query: 113 VLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD 172
+ L N + +L+IL L+ N T+ ++L L LILD
Sbjct: 165 KIFLQHNC----IRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDL---HQLTWLILD 217
Query: 173 HCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE---LTSLNHNE 229
I I R +GL ++ L + N L + + + + L + E + L ++
Sbjct: 218 DNPITRISQRL-FTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNST 276
Query: 230 LMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNI--LQPNL-KGFPSLRK 284
+ SLT L + N ++ FS ++L +D+S I L P+L K L+K
Sbjct: 277 FLSCDSLTVLFLPRN---QIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L+ N + YL N F + +L+ LDL I ++ F+ +K L H+
Sbjct: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHI 382
Score = 50.0 bits (114), Expect = 3e-05
Identities = 54/225 (24%), Positives = 97/225 (43%), Gaps = 8/225 (3%)
Query: 190 NIRVLKLNFNPLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYR 246
N+ +L L N + + + + + L+ +F+ + + ++ L +L L +++N
Sbjct: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
Query: 247 LELASSANNLFSQSLKYI--DISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNT 304
L Q I D I Q G SL + +N + L A
Sbjct: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
+L ++DL N I L TF L L L N+I +PE + + +L +L LS N +
Sbjct: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTI 317
Query: 365 SRVG-HL-RSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQ 406
+ + HL + + + L++SS L + K+ E L+ + LDL +
Sbjct: 318 TELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLER 362
>AF403384-1|AAL69324.2| 754|Homo sapiens LGR8 protein.
Length = 754
Score = 68.5 bits (160), Expect = 8e-11
Identities = 48/178 (26%), Positives = 86/178 (48%), Gaps = 5/178 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G +L+ LNHN + L F + +L +L L +N I + F GL L L +
Sbjct: 183 GLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVN 242
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLE 394
N + +P+ +MP L + L N YL+ L S+T+L + ++ + + +
Sbjct: 243 NYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFS 302
Query: 395 GLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
L+++ ELDLS N ++ + + + L+ LNL+ N + ++ F L +L SL +
Sbjct: 303 SLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
Score = 65.3 bits (152), Expect = 8e-10
Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 6/202 (2%)
Query: 279 FPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+ L+K L HN +R++ AF L+ L L++N I +LR F+ L L L L N
Sbjct: 160 YTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDN 219
Query: 339 EIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH---LRSMSVTILDMSSCELNTIGKDSLEG 395
I I + + SL L + NYL + + + +D+ + + +
Sbjct: 220 PITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLS 279
Query: 396 LQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
S+ L L +N + ++P+ S+ L L+L+ N I+ ++ F L L L++ N
Sbjct: 280 CDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSN 339
Query: 454 RFTMIWRRSFFDSNPYLERLDL 475
M ++ F+S L+ LDL
Sbjct: 340 PL-MYLHKNQFESLKQLQSLDL 360
Score = 64.9 bits (151), Expect = 1e-09
Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 11/243 (4%)
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
+N + V + + ++ +L L NK + L ++ + L+ + L H I I R
Sbjct: 125 VNGDLKSVPMISNNVTLLSLKKNKIHS---LPDKVFIKYTKLKKIFLQHNCIRHI-SRKA 180
Query: 185 LSGLINIRVLKLNFNPLLRIQNLISSSLRSL---FVSNCELTSLNHNELMFLPSLTHLKM 241
GL N+++L LN N + ++ I L L + + +T ++ L SL L M
Sbjct: 181 FFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSM 240
Query: 242 SNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF---PSLRKAILNHNMVRYLESN 298
NNY LE L ++D+ I F SL L N + ++
Sbjct: 241 VNNY-LEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEK 299
Query: 299 AFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLK 358
F++ L LDLS+N I L F+ LK+L+ L+LS N + + ++ + L L
Sbjct: 300 TFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLD 359
Query: 359 LSR 361
L R
Sbjct: 360 LER 362
Score = 53.6 bits (123), Expect = 2e-06
Identities = 66/250 (26%), Positives = 109/250 (43%), Gaps = 12/250 (4%)
Query: 129 PNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGL 188
P+ V + T LK + L N + + A L +L+ L L+H I ++ L
Sbjct: 153 PDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLC---NLQILYLNHNCITTLRP-GIFKDL 208
Query: 189 INIRVLKLNFNPLLRIQNLISSSLRSLF---VSNCELTSLNHNELMFLPSLTHLKMSNNY 245
+ L L+ NP+ RI + + L SLF + N L +L +P L + + N
Sbjct: 209 HQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGN- 267
Query: 246 RLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLR---KAILNHNMVRYLESNAFAN 302
R++ +++ L SL + + I K F SL+ + L+ N + L + F +
Sbjct: 268 RIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKD 327
Query: 303 NTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSR- 361
L+ L+LS+N + L + F LK L+ LDL EI I M +L+ +
Sbjct: 328 LKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNF 387
Query: 362 NYLSRVGHLR 371
Y S H+R
Sbjct: 388 RYCSYAPHVR 397
Score = 50.0 bits (114), Expect = 3e-05
Identities = 72/289 (24%), Positives = 122/289 (42%), Gaps = 22/289 (7%)
Query: 53 LTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALE 112
L P + T+L N + P +S +N+ L + N++ LPD T L+
Sbjct: 108 LKQYPQCCDCKETELECVNGDLKSVP-MIS--NNVTLLSLKKNKIHSLPDKVFIKYTKLK 164
Query: 113 VLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILD 172
+ L N + +L+IL L+ N T+ ++L L LILD
Sbjct: 165 KIFLQHNC----IRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDL---HQLTWLILD 217
Query: 173 HCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCE---LTSLNHNE 229
I I R +GL ++ L + N L + + + + L + E + L ++
Sbjct: 218 DNPITRISQRL-FTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNST 276
Query: 230 LMFLPSLTHLKMSNNYRLELASSANNLFS--QSLKYIDISYCNI--LQPNL-KGFPSLRK 284
+ SLT L + N ++ FS ++L +D+S I L P+L K L+K
Sbjct: 277 FLSCDSLTVLFLPRN---QIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQK 333
Query: 285 AILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L+ N + YL N F + +L+ LDL I ++ F+ +K L H+
Sbjct: 334 LNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHI 382
Score = 50.0 bits (114), Expect = 3e-05
Identities = 54/225 (24%), Positives = 97/225 (43%), Gaps = 8/225 (3%)
Query: 190 NIRVLKLNFNPLLRIQNLIS---SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYR 246
N+ +L L N + + + + + L+ +F+ + + ++ L +L L +++N
Sbjct: 138 NVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCI 197
Query: 247 LELASSANNLFSQSLKYI--DISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNT 304
L Q I D I Q G SL + +N + L A
Sbjct: 198 TTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMP 257
Query: 305 ELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYL 364
+L ++DL N I L TF L L L N+I +PE + + +L +L LS N +
Sbjct: 258 QLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTI 317
Query: 365 SRVG-HL-RSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQ 406
+ + HL + + + L++SS L + K+ E L+ + LDL +
Sbjct: 318 TELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLER 362
>AF240677-1|AAP88017.1| 1630|Homo sapiens CRIB1 protein.
Length = 1630
Score = 68.5 bits (160), Expect = 8e-11
Identities = 85/283 (30%), Positives = 132/283 (46%), Gaps = 29/283 (10%)
Query: 166 LETLILDHCEINSI------HGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSN 219
+E++ HC + ++ + RS L++ L+ P R+ NL R L +S+
Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNL-----RKLGLSD 68
Query: 220 CELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF 279
E+ L F+ L L +S N E+ S F ++L+ D S N L GF
Sbjct: 69 NEIQRLPPEVANFM-QLVELDVSRNDIPEIPESIK--FCKALEIADFSG-NPLSRLPDGF 124
Query: 280 PSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
LR LN ++ L + N L L+L N + SL + L L+ LDL
Sbjct: 125 TQLRSLAHLALNDVSLQALPGDV-GNLANLVTLELRENLLKSLPA-SLSFLVKLEQLDLG 182
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLS----RVGHLRSMSVTILDMSSCELNTIGKDS 392
N++ V+P D+L +P+L +L L RN LS +G+LR + LD+S L + +
Sbjct: 183 GNDLEVLP-DTLGALPNLRELWLDRNQLSALPPELGNLRRL--VCLDVSENRLEELPAE- 238
Query: 393 LEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSI 434
L GL + +L LSQNLL +PD I L L ++ NR+ +
Sbjct: 239 LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV 281
Score = 58.4 bits (135), Expect = 9e-08
Identities = 88/322 (27%), Positives = 144/322 (44%), Gaps = 29/322 (9%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF 121
L + KL +S+NE + P ++ LV LD+S N + +P++ + ALE+ + S N
Sbjct: 59 LNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKF-CKALEIADFSGNP- 116
Query: 122 DSWLNLNPNDV--LLPATHLKILDLSFNKFQ-TMGNLAN------QELLIR---PSLETL 169
L+ P+ L HL + D+S +GNLAN +E L++ SL L
Sbjct: 117 ---LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFL 173
Query: 170 I-LDHCEI--NSIHG-RSPLSGLINIRVLKLNFNPLLRIQNLISSSLR--SLFVSNCELT 223
+ L+ ++ N + L L N+R L L+ N L + + + R L VS L
Sbjct: 174 VKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLE 233
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS-YCNILQPNLKGFPSL 282
L EL L LT L +S N L L S+ +D + C + + + +L
Sbjct: 234 EL-PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA-IGDCENL 291
Query: 283 RKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAV 342
+ IL N++ L + T+L L++ N++ +L + G L L L N +AV
Sbjct: 292 SELILTENLLMAL-PRSLGKLTKLTNLNVDRNHLEALPPE-IGGCVALSVLSLRDNRLAV 349
Query: 343 IPEDSLLEMPSLTQLKLSRNYL 364
+P + L L L ++ N L
Sbjct: 350 LPPE-LAHTTELHVLDVAGNRL 370
Score = 54.4 bits (125), Expect = 1e-06
Identities = 75/302 (24%), Positives = 129/302 (42%), Gaps = 18/302 (5%)
Query: 45 DIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPD 102
++D SR + +IP + + + S N ++ P+ ++L +L +L ++ L+ LP
Sbjct: 86 ELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 145
Query: 103 NA--LYNLTALEVL-NLSRNYFDSWLNLNPNDVL-LPATHLKILDLSFNKFQTMGNL--- 155
+ L NL LE+ NL ++ S L + L L L++L + + L
Sbjct: 146 DVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
Query: 156 ANQELLIRPSLETL----ILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSS 211
NQ + P L L LD E + L GL+ + L L+ N L R+ + I
Sbjct: 206 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ- 264
Query: 212 LRSLFVSNCELTSLNH--NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + L + +L+ L ++ N + L S L + +D ++
Sbjct: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Query: 270 NILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD-TFRGLK 328
L P + G +L L N + L A+ TEL LD++ N + SL + T LK
Sbjct: 325 EALPPEIGGCVALSVLSLRDNRLAVLPPE-LAHTTELHVLDVAGNRLQSLPFALTHLNLK 383
Query: 329 ML 330
L
Sbjct: 384 AL 385
Score = 33.1 bits (72), Expect = 3.7
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 4/90 (4%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T+++ R L +P +G + ++ L++ +N P L+ L LD++ N+L+ LP
Sbjct: 315 TNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPND 131
AL +L L+ L L+ N L D
Sbjct: 375 -FALTHLN-LKALWLAENQAQPMLRFQTED 402
>AY899849-1|AAX85197.1| 709|Homo sapiens LGR7.2 protein.
Length = 709
Score = 68.1 bits (159), Expect = 1e-10
Identities = 58/202 (28%), Positives = 94/202 (46%), Gaps = 12/202 (5%)
Query: 273 QPNLKGFPSLRKAI----LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
+ NL+ PS+ + L N++R L + F N +L+ L L NN I S+ FRGL
Sbjct: 115 ETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 174
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-----HLRSMSVTILDMSSC 383
L L LS N I + ++ L L + N+LSR+ L S+ + +L M++
Sbjct: 175 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVL-MNNV 233
Query: 384 ELNTIGKDSLEGLQSIVELDLSQNLLSYIPD--SISSNTLKYLNLNYNRISSINNLTFFM 441
K + + + LDL N + + + IS + L L + N+I+ +N TF
Sbjct: 234 LTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAP 293
Query: 442 LNRLTSLSVVGNRFTMIWRRSF 463
L +L S+ G + I +R F
Sbjct: 294 LQKLDEFSLEGIEISNIQQRMF 315
Score = 42.3 bits (95), Expect = 0.006
Identities = 28/103 (27%), Positives = 52/103 (50%), Gaps = 2/103 (1%)
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSIN 435
L + + ++ +I + GL S+ +L LS N ++++ + + L++L + N +S I+
Sbjct: 155 LYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRIS 214
Query: 436 NLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
TF+ LN L L ++ N T + + P L LDL N
Sbjct: 215 PPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGN 257
Score = 33.5 bits (73), Expect = 2.8
Identities = 38/174 (21%), Positives = 71/174 (40%), Gaps = 7/174 (4%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL---FVSNCEL 222
L+ L L + +I SI + GL ++ L L+ N + ++ + L L + + L
Sbjct: 152 LQKLYLQNNKITSISIYA-FRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHL 210
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS---YCNILQPNLKGF 279
+ ++ L SL L + NN L L ++D+ N+
Sbjct: 211 SRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISC 270
Query: 280 PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
+L ++ N + +L N FA +L+ L I++++ FR L L H+
Sbjct: 271 SNLTVLVMRKNKINHLNENTFAPLQKLDEFSLEGIEISNIQQRMFRPLMNLSHI 324
Score = 33.1 bits (72), Expect = 3.7
Identities = 35/118 (29%), Positives = 50/118 (42%), Gaps = 7/118 (5%)
Query: 64 VTKLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFD 122
+TKL +S+N T P LH L L I N L + Y L +L +L L N
Sbjct: 176 LTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVL- 234
Query: 123 SWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIH 180
+ L P +P H LDL N NL N + +L L++ +IN ++
Sbjct: 235 TRLPDKPLCQHMPRLHW--LDLEGNHIH---NLRNLTFISCSNLTVLVMRKNKINHLN 287
>AY899851-1|AAX85199.1| 730|Homo sapiens LGR8.1 protein.
Length = 730
Score = 67.7 bits (158), Expect = 1e-10
Identities = 50/176 (28%), Positives = 83/176 (47%), Gaps = 5/176 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G +L+ LNHN + L F + +L +L L +N I + F GL L L +
Sbjct: 183 GLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVN 242
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRN---YLSRVGHLRSMSVTILDMSSCELNTIGKDSLE 394
N + +P+ +MP L + L N YL+ L S+T+LD+SS + + +
Sbjct: 243 NYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLDLSSNTITELSPHLFK 302
Query: 395 GLQSIVELDLSQNLLSYIPDS--ISSNTLKYLNLNYNRISSINNLTFFMLNRLTSL 448
L+ + +L+LS N L Y+ + S L+ L+L I +IN F + L+ +
Sbjct: 303 DLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHI 358
Score = 60.1 bits (139), Expect = 3e-08
Identities = 46/177 (25%), Positives = 80/177 (45%), Gaps = 5/177 (2%)
Query: 279 FPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+ L+K L HN +R++ AF L+ L L++N I +LR F+ L L L L N
Sbjct: 160 YTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDN 219
Query: 339 EIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH---LRSMSVTILDMSSCELNTIGKDSLEG 395
I I + + SL L + NYL + + + +D+ + + +
Sbjct: 220 PITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLS 279
Query: 396 LQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINNLTFFMLNRLTSLSV 450
S+ LDLS N ++ + + + L+ LNL+ N + ++ F L +L SL +
Sbjct: 280 CDSLTVLDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 336
Score = 59.7 bits (138), Expect = 4e-08
Identities = 59/211 (27%), Positives = 98/211 (46%), Gaps = 11/211 (5%)
Query: 129 PNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGL 188
P+ V + T LK + L N + + A L +L+ L L+H I ++ L
Sbjct: 153 PDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLC---NLQILYLNHNCITTLRP-GIFKDL 208
Query: 189 INIRVLKLNFNPLLRIQNLISSSLRSLF---VSNCELTSLNHNELMFLPSLTHLKMSNNY 245
+ L L+ NP+ RI + + L SLF + N L +L +P L + + N
Sbjct: 209 HQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGN- 267
Query: 246 RLELASSANNLFSQSLKYIDISYCNI--LQPNL-KGFPSLRKAILNHNMVRYLESNAFAN 302
R++ +++ L SL +D+S I L P+L K L+K L+ N + YL N F +
Sbjct: 268 RIKYLTNSTFLSCDSLTVLDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFES 327
Query: 303 NTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
+L+ LDL I ++ F+ +K L H+
Sbjct: 328 LKQLQSLDLERIEIPNINTRMFQPMKNLSHI 358
Score = 54.0 bits (124), Expect = 2e-06
Identities = 52/183 (28%), Positives = 81/183 (44%), Gaps = 8/183 (4%)
Query: 301 ANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLS 360
+NN L L L N I SL F LK + L N I I + + +L L L+
Sbjct: 136 SNNVTL--LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLN 193
Query: 361 RNYLS--RVGHLRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSIS 417
N ++ R G + + +T L + + I + GL S+ L + N L +P +
Sbjct: 194 HNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMC 253
Query: 418 SNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDL 475
+ L +++L NRI + N TF + LT L + N T + F D L++L+L
Sbjct: 254 AQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLDLSSNTITELSPHLFKDLK-LLQKLNL 312
Query: 476 SDN 478
S N
Sbjct: 313 SSN 315
Score = 52.8 bits (121), Expect = 4e-06
Identities = 53/214 (24%), Positives = 94/214 (43%), Gaps = 15/214 (7%)
Query: 208 ISSSLRS--LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKY-- 263
++ L+S + +N L SL N++ LP +K + ++ L + S+ +
Sbjct: 125 VNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGL 184
Query: 264 --IDISYCN-----ILQPNL-KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNN 315
+ I Y N L+P + K L IL+ N + + F L +L + NN
Sbjct: 185 CNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNY 244
Query: 316 IASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG-HL-RSM 373
+ +L + L +DL N I + + L SLT L LS N ++ + HL + +
Sbjct: 245 LEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLDLSSNTITELSPHLFKDL 304
Query: 374 S-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQ 406
+ L++SS L + K+ E L+ + LDL +
Sbjct: 305 KLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLER 338
Score = 39.1 bits (87), Expect = 0.057
Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 16/187 (8%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF 121
LQ+ LN N T P LH L L + N + + L +L L++ NY
Sbjct: 187 LQILYLN-HNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYL 245
Query: 122 DSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHG 181
++ P + L +DL N+ + L N L SL L L N+I
Sbjct: 246 EAL----PKQMCAQMPQLNWVDLEGNRIK---YLTNSTFLSCDSLTVLDLSS---NTITE 295
Query: 182 RSP--LSGLINIRVLKLNFNPLLRI-QNLISS--SLRSLFVSNCELTSLNHNELMFLPSL 236
SP L ++ L L+ NPL+ + +N S L+SL + E+ ++N + +L
Sbjct: 296 LSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNL 355
Query: 237 THLKMSN 243
+H+ N
Sbjct: 356 SHIYFKN 362
>AL356953-4|CAI15930.1| 828|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 6 protein.
Length = 828
Score = 67.7 bits (158), Expect = 1e-10
Identities = 73/279 (26%), Positives = 125/279 (44%), Gaps = 15/279 (5%)
Query: 91 DISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQ 150
D+S N L L ++L LE L LS N+ L+ P LKIL L N+
Sbjct: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNH----LSHIPGQAFSGLYSLKILMLQNNQ-- 82
Query: 151 TMGNLANQELLIRPSLETLILDHCEINSIH-GRSPLSGLINIRVLKLNFNPLLRIQNLIS 209
+G + + L PSL++L L++ ++ L L + N + + +
Sbjct: 83 -LGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN 141
Query: 210 SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+++ + + + + +LP L L + N +++ + + SL+ + ++
Sbjct: 142 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDLKGTTSLEILTLTRA 199
Query: 270 NI-LQPN--LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRG 326
I L P+ + P LR L+HN + L S +LE + L +N I + DTF
Sbjct: 200 GIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQ 257
Query: 327 LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
L L+ LDLSWN I I ++ + SL +L L+ N L+
Sbjct: 258 LSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLT 296
Score = 63.3 bits (147), Expect = 3e-09
Identities = 86/326 (26%), Positives = 145/326 (44%), Gaps = 25/326 (7%)
Query: 47 DCSRRGLTDIPNGLGLQVT---KLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPD 102
D S LT++ GL + +L +S N + P ++ S L++L L + +NQL G+P
Sbjct: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
Query: 103 NALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLI 162
AL+ L +L+ L+L+ N + P + T ++ +L F+ + + + +
Sbjct: 89 EALWELPSLQSLDLNYNKLQEF----PVAI---RTLGRLQELGFHN-NNIKAIPEKAFMG 140
Query: 163 RPSLETLILDHCEINSIHGRSPLSGLINIRVLKLN-FNPLLRIQNLI-SSSLRSLFVSNC 220
P L+T+ I + GRS L + L LN + +L ++SL L ++
Sbjct: 141 NPLLQTIHFYDNPIQFV-GRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRA 199
Query: 221 ELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF- 279
+ L LP L L++S+N EL S Q L+ I + + I + F
Sbjct: 200 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHR---CQKLEEIGLQHNRIWEIGADTFS 256
Query: 280 --PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
SL+ L+ N +R + AF+ L LDL++N + +L GL L HL L
Sbjct: 257 QLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKG 313
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNY 363
N +A+ S P L L++ Y
Sbjct: 314 N-LALSQAFSKDSFPKLRILEVPYAY 338
Score = 54.8 bits (126), Expect = 1e-06
Identities = 71/260 (27%), Positives = 111/260 (42%), Gaps = 21/260 (8%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSL 225
LE L L ++ I G++ SGL ++++L L N L I L SL + L
Sbjct: 49 LEELRLSGNHLSHIPGQA-FSGLYSLKILMLQNNQLGGIPAEALWELPSL-----QSLDL 102
Query: 226 NHNELMFLP-------SLTHLKMSNNYRLELASSA--NNLFSQSLKYIDISYCNILQPNL 276
N+N+L P L L NN + A N Q++ + D + +
Sbjct: 103 NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAF 162
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+ P L LN M E T LE L L+ I L + L L+ L+LS
Sbjct: 163 QYLPKLHTLSLNGAM-DIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 221
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDSL 393
N+I +P SL L ++ L N + +G + S+ LD+S + +I ++
Sbjct: 222 HNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAF 279
Query: 394 EGLQSIVELDLSQNLLSYIP 413
L S+V+LDL+ N L+ +P
Sbjct: 280 STLHSLVKLDLTDNQLTTLP 299
Score = 43.2 bits (97), Expect = 0.003
Identities = 38/147 (25%), Positives = 64/147 (43%), Gaps = 4/147 (2%)
Query: 310 DLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH 369
DLS NN+ L+ F L+ L+ L LS N ++ IP + + SL L L N L +
Sbjct: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
Query: 370 LRSMSVTILDMSSCELNTIGK--DSLEGLQSIVELDLSQNLLSYIPDS--ISSNTLKYLN 425
+ L N + + ++ L + EL N + IP+ + + L+ ++
Sbjct: 89 EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
Query: 426 LNYNRISSINNLTFFMLNRLTSLSVVG 452
N I + F L +L +LS+ G
Sbjct: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNG 175
>AF271734-1|AAP88018.1| 1601|Homo sapiens SCRIB1 variant N1 protein.
Length = 1601
Score = 67.7 bits (158), Expect = 1e-10
Identities = 75/232 (32%), Positives = 112/232 (48%), Gaps = 18/232 (7%)
Query: 211 SLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCN 270
+LR L +S+ E+ L F+ L L +S N E+ S F ++L+ D S N
Sbjct: 31 NLRKLGLSDNEIQRLPPEVANFM-QLVELDVSRNDIPEIPESIK--FCKALEIADFSG-N 86
Query: 271 ILQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGL 327
L GF LR LN ++ L + N L L+L N + SL + L
Sbjct: 87 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDV-GNLANLVTLELRENLLKSLPA-SLSFL 144
Query: 328 KMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS----RVGHLRSMSVTILDMSSC 383
L+ LDL N++ V+P D+L +P+L +L L RN LS +G+LR + LD+S
Sbjct: 145 VKLEQLDLGGNDLEVLP-DTLGALPNLRELWLDRNQLSALPPELGNLRRL--VCLDVSEN 201
Query: 384 ELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSI 434
L + + L GL + +L LSQNLL +PD I L L ++ NR+ +
Sbjct: 202 RLEELPAE-LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV 252
Score = 58.4 bits (135), Expect = 9e-08
Identities = 88/322 (27%), Positives = 144/322 (44%), Gaps = 29/322 (9%)
Query: 62 LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYF 121
L + KL +S+NE + P ++ LV LD+S N + +P++ + ALE+ + S N
Sbjct: 30 LNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKF-CKALEIADFSGNP- 87
Query: 122 DSWLNLNPNDV--LLPATHLKILDLSFNKFQ-TMGNLAN------QELLIR---PSLETL 169
L+ P+ L HL + D+S +GNLAN +E L++ SL L
Sbjct: 88 ---LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFL 144
Query: 170 I-LDHCEI--NSIHG-RSPLSGLINIRVLKLNFNPLLRIQNLISSSLR--SLFVSNCELT 223
+ L+ ++ N + L L N+R L L+ N L + + + R L VS L
Sbjct: 145 VKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLE 204
Query: 224 SLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS-YCNILQPNLKGFPSL 282
L EL L LT L +S N L L S+ +D + C + + + +L
Sbjct: 205 EL-PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA-IGDCENL 262
Query: 283 RKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAV 342
+ IL N++ L + T+L L++ N++ +L + G L L L N +AV
Sbjct: 263 SELILTENLLMAL-PRSLGKLTKLTNLNVDRNHLEALPPE-IGGCVALSVLSLRDNRLAV 320
Query: 343 IPEDSLLEMPSLTQLKLSRNYL 364
+P + L L L ++ N L
Sbjct: 321 LPPE-LAHTTELHVLDVAGNRL 341
Score = 54.4 bits (125), Expect = 1e-06
Identities = 75/302 (24%), Positives = 129/302 (42%), Gaps = 18/302 (5%)
Query: 45 DIDCSRRGLTDIPNGLGL--QVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPD 102
++D SR + +IP + + + S N ++ P+ ++L +L +L ++ L+ LP
Sbjct: 57 ELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 116
Query: 103 NA--LYNLTALEVL-NLSRNYFDSWLNLNPNDVL-LPATHLKILDLSFNKFQTMGNL--- 155
+ L NL LE+ NL ++ S L + L L L++L + + L
Sbjct: 117 DVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 176
Query: 156 ANQELLIRPSLETL----ILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSS 211
NQ + P L L LD E + L GL+ + L L+ N L R+ + I
Sbjct: 177 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ- 235
Query: 212 LRSLFVSNCELTSLNH--NELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+ L + + L + +L+ L ++ N + L S L + +D ++
Sbjct: 236 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 295
Query: 270 NILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYD-TFRGLK 328
L P + G +L L N + L A+ TEL LD++ N + SL + T LK
Sbjct: 296 EALPPEIGGCVALSVLSLRDNRLAVLPPE-LAHTTELHVLDVAGNRLQSLPFALTHLNLK 354
Query: 329 ML 330
L
Sbjct: 355 AL 356
Score = 33.1 bits (72), Expect = 3.7
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 4/90 (4%)
Query: 44 TDIDCSRRGLTDIPNGLG--LQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLP 101
T+++ R L +P +G + ++ L++ +N P L+ L LD++ N+L+ LP
Sbjct: 286 TNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 345
Query: 102 DNALYNLTALEVLNLSRNYFDSWLNLNPND 131
AL +L L+ L L+ N L D
Sbjct: 346 -FALTHLN-LKALWLAENQAQPMLRFQTED 373
>AF190501-1|AAG17168.1| 828|Homo sapiens leucine-rich
repeat-containing G protein-coupled receptor 6 protein.
Length = 828
Score = 67.7 bits (158), Expect = 1e-10
Identities = 73/279 (26%), Positives = 125/279 (44%), Gaps = 15/279 (5%)
Query: 91 DISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQ 150
D+S N L L ++L LE L LS N+ L+ P LKIL L N+
Sbjct: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNH----LSHIPGQAFSGLYSLKILMLQNNQ-- 82
Query: 151 TMGNLANQELLIRPSLETLILDHCEINSIH-GRSPLSGLINIRVLKLNFNPLLRIQNLIS 209
+G + + L PSL++L L++ ++ L L + N + + +
Sbjct: 83 -LGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN 141
Query: 210 SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYC 269
L+++ + + + + +LP L L + N +++ + + SL+ + ++
Sbjct: 142 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDLKGTTSLEILTLTRA 199
Query: 270 NI-LQPN--LKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRG 326
I L P+ + P LR L+HN + L S +LE + L +N I + DTF
Sbjct: 200 GIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQ 257
Query: 327 LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
L L+ LDLSWN I I ++ + SL +L L+ N L+
Sbjct: 258 LSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLT 296
Score = 63.3 bits (147), Expect = 3e-09
Identities = 86/326 (26%), Positives = 145/326 (44%), Gaps = 25/326 (7%)
Query: 47 DCSRRGLTDIPNGLGLQVT---KLNISNNEFTKFP-ESLSRLHNLVNLDISSNQLKGLPD 102
D S LT++ GL + +L +S N + P ++ S L++L L + +NQL G+P
Sbjct: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
Query: 103 NALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLI 162
AL+ L +L+ L+L+ N + P + T ++ +L F+ + + + +
Sbjct: 89 EALWELPSLQSLDLNYNKLQEF----PVAI---RTLGRLQELGFHN-NNIKAIPEKAFMG 140
Query: 163 RPSLETLILDHCEINSIHGRSPLSGLINIRVLKLN-FNPLLRIQNLI-SSSLRSLFVSNC 220
P L+T+ I + GRS L + L LN + +L ++SL L ++
Sbjct: 141 NPLLQTIHFYDNPIQFV-GRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRA 199
Query: 221 ELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGF- 279
+ L LP L L++S+N EL S Q L+ I + + I + F
Sbjct: 200 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHR---CQKLEEIGLQHNRIWEIGADTFS 256
Query: 280 --PSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
SL+ L+ N +R + AF+ L LDL++N + +L GL L HL L
Sbjct: 257 QLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKG 313
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNY 363
N +A+ S P L L++ Y
Sbjct: 314 N-LALSQAFSKDSFPKLRILEVPYAY 338
Score = 54.8 bits (126), Expect = 1e-06
Identities = 71/260 (27%), Positives = 111/260 (42%), Gaps = 21/260 (8%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSL 225
LE L L ++ I G++ SGL ++++L L N L I L SL + L
Sbjct: 49 LEELRLSGNHLSHIPGQA-FSGLYSLKILMLQNNQLGGIPAEALWELPSL-----QSLDL 102
Query: 226 NHNELMFLP-------SLTHLKMSNNYRLELASSA--NNLFSQSLKYIDISYCNILQPNL 276
N+N+L P L L NN + A N Q++ + D + +
Sbjct: 103 NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAF 162
Query: 277 KGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLS 336
+ P L LN M E T LE L L+ I L + L L+ L+LS
Sbjct: 163 QYLPKLHTLSLNGAM-DIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 221
Query: 337 WNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVG---HLRSMSVTILDMSSCELNTIGKDSL 393
N+I +P SL L ++ L N + +G + S+ LD+S + +I ++
Sbjct: 222 HNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAF 279
Query: 394 EGLQSIVELDLSQNLLSYIP 413
L S+V+LDL+ N L+ +P
Sbjct: 280 STLHSLVKLDLTDNQLTTLP 299
Score = 43.2 bits (97), Expect = 0.003
Identities = 38/147 (25%), Positives = 64/147 (43%), Gaps = 4/147 (2%)
Query: 310 DLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH 369
DLS NN+ L+ F L+ L+ L LS N ++ IP + + SL L L N L +
Sbjct: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
Query: 370 LRSMSVTILDMSSCELNTIGK--DSLEGLQSIVELDLSQNLLSYIPDS--ISSNTLKYLN 425
+ L N + + ++ L + EL N + IP+ + + L+ ++
Sbjct: 89 EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
Query: 426 LNYNRISSINNLTFFMLNRLTSLSVVG 452
N I + F L +L +LS+ G
Sbjct: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNG 175
>BC111745-1|AAI11746.1| 653|Homo sapiens leucine rich repeat
containing 4 protein.
Length = 653
Score = 67.3 bits (157), Expect = 2e-10
Identities = 65/253 (25%), Positives = 116/253 (45%), Gaps = 33/253 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISS 94
+C C+ + + C+RRGL+++P G+ LN+ N ++ LH+L L +
Sbjct: 49 VCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGR 108
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDL---------- 144
N ++ + A L +L L L FD+WL + P+ + L+ L L
Sbjct: 109 NSIRQIEVGAFNGLASLNTLEL----FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPS 164
Query: 145 -SFNKFQT-----MGNLANQELLIRPSLETLI------LDHCEINSIHGRSPLSGLINIR 192
+FN+ + +G L E + + E L L C I + +PL GL +
Sbjct: 165 YAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELE 224
Query: 193 VLKLNFNPLLRIQNLIS-SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELAS 251
+ +F P +R + SSL+ L+V N +++ + N L SL L +++N L+S
Sbjct: 225 MSGNHF-PEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHN---NLSS 280
Query: 252 SANNLFSQSLKYI 264
++LF+ L+Y+
Sbjct: 281 LPHDLFT-PLRYL 292
Score = 64.9 bits (151), Expect = 1e-09
Identities = 55/207 (26%), Positives = 98/207 (47%), Gaps = 6/207 (2%)
Query: 277 KGFPSLRKAI-LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
+G PS + + L N ++ ++++ F + LE L L N+I + F GL L L+L
Sbjct: 71 QGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSC-ELNTIGKD 391
N + VIP + + L +L L N + + R S+ LD+ +L I +
Sbjct: 131 FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEG 190
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
+ EGL ++ L+L + +P+ L+ L ++ N I +F L+ L L V+
Sbjct: 191 AFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDN 478
++ ++I R+ FD L L+L+ N
Sbjct: 251 NSQVSLI-ERNAFDGLASLVELNLAHN 276
Score = 64.5 bits (150), Expect = 1e-09
Identities = 57/204 (27%), Positives = 88/204 (43%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N +R +E AF L L+L +N + + F L L+ L L N I IP
Sbjct: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L Y+S ++ L++ C + + +L L + EL
Sbjct: 166 AFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDM--PNLTPLVGLEEL 223
Query: 403 DLSQNLLSYI-PDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
++S N I P S ++LK L + +++S I F L L L++ N + +
Sbjct: 224 EMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSL-P 282
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F YL L L N W CDC
Sbjct: 283 HDLFTPLRYLVELHLHHNPWNCDC 306
Score = 54.8 bits (126), Expect = 1e-06
Identities = 58/223 (26%), Positives = 104/223 (46%), Gaps = 9/223 (4%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFS-QSLKYID 265
I S+ R L + + + + L L L++ N ++ A N L S +L+ D
Sbjct: 73 IPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFD 132
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIASLRYDTF 324
I + LR+ L +N + + S AF L LDL + + F
Sbjct: 133 NWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAF 192
Query: 325 RGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMS 381
GL LK+L+L I +P +L + L +L++S N+ + G +S + L +
Sbjct: 193 EGLFNLKYLNLGMCNIKDMP--NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL 424
+ +++ I +++ +GL S+VEL+L+ N LS +P + + L+YL
Sbjct: 251 NSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFT-PLRYL 292
Score = 49.6 bits (113), Expect = 4e-05
Identities = 58/201 (28%), Positives = 87/201 (43%), Gaps = 29/201 (14%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCEL 222
LE L L I I + +GL ++ L+L N L I + S LR L++ N +
Sbjct: 101 LEVLQLGRNSIRQIEVGA-FNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNLK---- 277
S+ +PSL L + +LE S +LKY+++ CNI PNL
Sbjct: 160 ESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVG 219
Query: 278 --------------------GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIA 317
G SL+K + ++ V +E NAF L L+L++NN++
Sbjct: 220 LEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLS 279
Query: 318 SLRYDTFRGLKMLKHLDLSWN 338
SL +D F L+ L L L N
Sbjct: 280 SLPHDLFTPLRYLVELHLHHN 300
>BC111561-1|AAI11562.1| 653|Homo sapiens leucine rich repeat
containing 4 protein.
Length = 653
Score = 67.3 bits (157), Expect = 2e-10
Identities = 65/253 (25%), Positives = 116/253 (45%), Gaps = 33/253 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISS 94
+C C+ + + C+RRGL+++P G+ LN+ N ++ LH+L L +
Sbjct: 49 VCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGR 108
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDL---------- 144
N ++ + A L +L L L FD+WL + P+ + L+ L L
Sbjct: 109 NSIRQIEVGAFNGLASLNTLEL----FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPS 164
Query: 145 -SFNKFQT-----MGNLANQELLIRPSLETLI------LDHCEINSIHGRSPLSGLINIR 192
+FN+ + +G L E + + E L L C I + +PL GL +
Sbjct: 165 YAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELE 224
Query: 193 VLKLNFNPLLRIQNLIS-SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELAS 251
+ +F P +R + SSL+ L+V N +++ + N L SL L +++N L+S
Sbjct: 225 MSGNHF-PEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHN---NLSS 280
Query: 252 SANNLFSQSLKYI 264
++LF+ L+Y+
Sbjct: 281 LPHDLFT-PLRYL 292
Score = 64.9 bits (151), Expect = 1e-09
Identities = 55/207 (26%), Positives = 98/207 (47%), Gaps = 6/207 (2%)
Query: 277 KGFPSLRKAI-LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
+G PS + + L N ++ ++++ F + LE L L N+I + F GL L L+L
Sbjct: 71 QGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSC-ELNTIGKD 391
N + VIP + + L +L L N + + R S+ LD+ +L I +
Sbjct: 131 FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEG 190
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
+ EGL ++ L+L + +P+ L+ L ++ N I +F L+ L L V+
Sbjct: 191 AFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDN 478
++ ++I R+ FD L L+L+ N
Sbjct: 251 NSQVSLI-ERNAFDGLASLVELNLAHN 276
Score = 64.5 bits (150), Expect = 1e-09
Identities = 57/204 (27%), Positives = 88/204 (43%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N +R +E AF L L+L +N + + F L L+ L L N I IP
Sbjct: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L Y+S ++ L++ C + + +L L + EL
Sbjct: 166 AFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDM--PNLTPLVGLEEL 223
Query: 403 DLSQNLLSYI-PDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
++S N I P S ++LK L + +++S I F L L L++ N + +
Sbjct: 224 EMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSL-P 282
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F YL L L N W CDC
Sbjct: 283 HDLFTPLRYLVELHLHHNPWNCDC 306
Score = 54.8 bits (126), Expect = 1e-06
Identities = 58/223 (26%), Positives = 104/223 (46%), Gaps = 9/223 (4%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFS-QSLKYID 265
I S+ R L + + + + L L L++ N ++ A N L S +L+ D
Sbjct: 73 IPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFD 132
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIASLRYDTF 324
I + LR+ L +N + + S AF L LDL + + F
Sbjct: 133 NWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAF 192
Query: 325 RGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMS 381
GL LK+L+L I +P +L + L +L++S N+ + G +S + L +
Sbjct: 193 EGLFNLKYLNLGMCNIKDMP--NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL 424
+ +++ I +++ +GL S+VEL+L+ N LS +P + + L+YL
Sbjct: 251 NSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFT-PLRYL 292
Score = 49.6 bits (113), Expect = 4e-05
Identities = 58/201 (28%), Positives = 87/201 (43%), Gaps = 29/201 (14%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCEL 222
LE L L I I + +GL ++ L+L N L I + S LR L++ N +
Sbjct: 101 LEVLQLGRNSIRQIEVGA-FNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNLK---- 277
S+ +PSL L + +LE S +LKY+++ CNI PNL
Sbjct: 160 ESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVG 219
Query: 278 --------------------GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIA 317
G SL+K + ++ V +E NAF L L+L++NN++
Sbjct: 220 LEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLS 279
Query: 318 SLRYDTFRGLKMLKHLDLSWN 338
SL +D F L+ L L L N
Sbjct: 280 SLPHDLFTPLRYLVELHLHHN 300
>BC045113-1|AAH45113.1| 522|Homo sapiens LRRTM1 protein protein.
Length = 522
Score = 67.3 bits (157), Expect = 2e-10
Identities = 79/321 (24%), Positives = 132/321 (41%), Gaps = 16/321 (4%)
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL-ASSANNLFSQSLKYIDISY-CN 270
R L+ LT HN L L L + N EL A L + Y+D ++ C+
Sbjct: 48 RLLYCEALNLTEAPHN----LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICS 103
Query: 271 ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
+ + +++ L+ N + L + F L +DLS N + +L D F GL+ L
Sbjct: 104 VQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKL 163
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY---LSRVGHLRSMSVTILDMSSCELNT 387
L + N I +P + SL L + N L+R +T L + +L
Sbjct: 164 TTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVK 223
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIPDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLT 446
+ L S+ L L +N ++ + S+ L+ ++L+ N I + F + L
Sbjct: 224 VNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQ 283
Query: 447 SLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEES 506
SL + NR T I R +S L + L+ N+W C N+ +++ + +
Sbjct: 284 SLQLDSNRLTYIEPR-ILNSWKSLTSITLAGNLWDC---GRNVCALASWLSNFQGRYDG- 338
Query: 507 FNLICNSPANVNTQTWLEACY 527
NL C SP + L+A Y
Sbjct: 339 -NLQCASPEYAQGEDVLDAVY 358
Score = 50.0 bits (114), Expect = 3e-05
Identities = 72/305 (23%), Positives = 123/305 (40%), Gaps = 34/305 (11%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
LCRC + + C LT+ P+ L + L++ N ++ + L L L +
Sbjct: 42 LCRC--EGRLLYCEALNLTEAPHNLS-GLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDH 98
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N + + +A L ++ L LS N PN P +L+ +DLS+NK Q +
Sbjct: 99 NHICSVQGDAFQKLRRVKELTLSSNQITQL----PNTTFRPMPNLRSVDLSYNKLQALA- 153
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
P L HG L+ L ++R + F P+ Q+ SL+
Sbjct: 154 ---------PDL------------FHGLRKLTTL-HMRANAIQFVPVRIFQD--CRSLKF 189
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL-ASSANNLFSQSLKYIDISYCNILQ 273
L + +L SL N L LT L + +N +++ + L S + + I+
Sbjct: 190 LDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVV 249
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
+L +L K L+ N + Y+E + F L+ L L +N + + K L +
Sbjct: 250 SSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSI 309
Query: 334 DLSWN 338
L+ N
Sbjct: 310 TLAGN 314
>AY358310-1|AAQ88677.1| 522|Homo sapiens DFLL675 protein.
Length = 522
Score = 67.3 bits (157), Expect = 2e-10
Identities = 79/321 (24%), Positives = 132/321 (41%), Gaps = 16/321 (4%)
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL-ASSANNLFSQSLKYIDISY-CN 270
R L+ LT HN L L L + N EL A L + Y+D ++ C+
Sbjct: 48 RLLYCEALNLTEAPHN----LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICS 103
Query: 271 ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
+ + +++ L+ N + L + F L +DLS N + +L D F GL+ L
Sbjct: 104 VQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKL 163
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY---LSRVGHLRSMSVTILDMSSCELNT 387
L + N I +P + SL L + N L+R +T L + +L
Sbjct: 164 TTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVK 223
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIPDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLT 446
+ L S+ L L +N ++ + S+ L+ ++L+ N I + F + L
Sbjct: 224 VNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQ 283
Query: 447 SLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDFYDFVTLEPNKKEES 506
SL + NR T I R +S L + L+ N+W C N+ +++ + +
Sbjct: 284 SLQLDSNRLTYIEPR-ILNSWKSLTSITLAGNLWDC---GRNVCALASWLSNFQGRYDG- 338
Query: 507 FNLICNSPANVNTQTWLEACY 527
NL C SP + L+A Y
Sbjct: 339 -NLQCASPEYAQGEDVLDAVY 358
Score = 50.0 bits (114), Expect = 3e-05
Identities = 72/305 (23%), Positives = 123/305 (40%), Gaps = 34/305 (11%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
LCRC + + C LT+ P+ L + L++ N ++ + L L L +
Sbjct: 42 LCRC--EGRLLYCEALNLTEAPHNLS-GLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDH 98
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N + + +A L ++ L LS N PN P +L+ +DLS+NK Q +
Sbjct: 99 NHICSVQGDAFQKLRRVKELTLSSNQITQL----PNTTFRPMPNLRSVDLSYNKLQALA- 153
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
P L HG L+ L ++R + F P+ Q+ SL+
Sbjct: 154 ---------PDL------------FHGLRKLTTL-HMRANAIQFVPVRIFQD--CRSLKF 189
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL-ASSANNLFSQSLKYIDISYCNILQ 273
L + +L SL N L LT L + +N +++ + L S + + I+
Sbjct: 190 LDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVV 249
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
+L +L K L+ N + Y+E + F L+ L L +N + + K L +
Sbjct: 250 SSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSI 309
Query: 334 DLSWN 338
L+ N
Sbjct: 310 TLAGN 314
>AY358307-1|AAQ88674.1| 653|Homo sapiens NAG14 protein.
Length = 653
Score = 67.3 bits (157), Expect = 2e-10
Identities = 65/253 (25%), Positives = 116/253 (45%), Gaps = 33/253 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISS 94
+C C+ + + C+RRGL+++P G+ LN+ N ++ LH+L L +
Sbjct: 49 VCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGR 108
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDL---------- 144
N ++ + A L +L L L FD+WL + P+ + L+ L L
Sbjct: 109 NSIRQIEVGAFNGLASLNTLEL----FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPS 164
Query: 145 -SFNKFQT-----MGNLANQELLIRPSLETLI------LDHCEINSIHGRSPLSGLINIR 192
+FN+ + +G L E + + E L L C I + +PL GL +
Sbjct: 165 YAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELE 224
Query: 193 VLKLNFNPLLRIQNLIS-SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELAS 251
+ +F P +R + SSL+ L+V N +++ + N L SL L +++N L+S
Sbjct: 225 MSGNHF-PEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHN---NLSS 280
Query: 252 SANNLFSQSLKYI 264
++LF+ L+Y+
Sbjct: 281 LPHDLFT-PLRYL 292
Score = 64.9 bits (151), Expect = 1e-09
Identities = 55/207 (26%), Positives = 98/207 (47%), Gaps = 6/207 (2%)
Query: 277 KGFPSLRKAI-LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
+G PS + + L N ++ ++++ F + LE L L N+I + F GL L L+L
Sbjct: 71 QGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSC-ELNTIGKD 391
N + VIP + + L +L L N + + R S+ LD+ +L I +
Sbjct: 131 FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEG 190
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
+ EGL ++ L+L + +P+ L+ L ++ N I +F L+ L L V+
Sbjct: 191 AFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDN 478
++ ++I R+ FD L L+L+ N
Sbjct: 251 NSQVSLI-ERNAFDGLASLVELNLAHN 276
Score = 64.5 bits (150), Expect = 1e-09
Identities = 57/204 (27%), Positives = 88/204 (43%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N +R +E AF L L+L +N + + F L L+ L L N I IP
Sbjct: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L Y+S ++ L++ C + + +L L + EL
Sbjct: 166 AFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDM--PNLTPLVGLEEL 223
Query: 403 DLSQNLLSYI-PDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
++S N I P S ++LK L + +++S I F L L L++ N + +
Sbjct: 224 EMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSL-P 282
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F YL L L N W CDC
Sbjct: 283 HDLFTPLRYLVELHLHHNPWNCDC 306
Score = 54.8 bits (126), Expect = 1e-06
Identities = 58/223 (26%), Positives = 104/223 (46%), Gaps = 9/223 (4%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFS-QSLKYID 265
I S+ R L + + + + L L L++ N ++ A N L S +L+ D
Sbjct: 73 IPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFD 132
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIASLRYDTF 324
I + LR+ L +N + + S AF L LDL + + F
Sbjct: 133 NWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAF 192
Query: 325 RGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMS 381
GL LK+L+L I +P +L + L +L++S N+ + G +S + L +
Sbjct: 193 EGLFNLKYLNLGMCNIKDMP--NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL 424
+ +++ I +++ +GL S+VEL+L+ N LS +P + + L+YL
Sbjct: 251 NSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFT-PLRYL 292
Score = 49.6 bits (113), Expect = 4e-05
Identities = 58/201 (28%), Positives = 87/201 (43%), Gaps = 29/201 (14%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCEL 222
LE L L I I + +GL ++ L+L N L I + S LR L++ N +
Sbjct: 101 LEVLQLGRNSIRQIEVGA-FNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNLK---- 277
S+ +PSL L + +LE S +LKY+++ CNI PNL
Sbjct: 160 ESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVG 219
Query: 278 --------------------GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIA 317
G SL+K + ++ V +E NAF L L+L++NN++
Sbjct: 220 LEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLS 279
Query: 318 SLRYDTFRGLKMLKHLDLSWN 338
SL +D F L+ L L L N
Sbjct: 280 SLPHDLFTPLRYLVELHLHHN 300
>AK172751-1|BAD18737.1| 653|Homo sapiens protein ( Homo sapiens
cDNA FLJ23912 fis, clone CAE04210, highly similar to
Homo sapiens leucine rich repeat containing 4 (LRRC4).
).
Length = 653
Score = 67.3 bits (157), Expect = 2e-10
Identities = 65/253 (25%), Positives = 116/253 (45%), Gaps = 33/253 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISS 94
+C C+ + + C+RRGL+++P G+ LN+ N ++ LH+L L +
Sbjct: 49 VCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGR 108
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDL---------- 144
N ++ + A L +L L L FD+WL + P+ + L+ L L
Sbjct: 109 NSIRQIEVGAFNGLASLNTLEL----FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPS 164
Query: 145 -SFNKFQT-----MGNLANQELLIRPSLETLI------LDHCEINSIHGRSPLSGLINIR 192
+FN+ + +G L E + + E L L C I + +PL GL +
Sbjct: 165 YAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELE 224
Query: 193 VLKLNFNPLLRIQNLIS-SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELAS 251
+ +F P +R + SSL+ L+V N +++ + N L SL L +++N L+S
Sbjct: 225 MSGNHF-PEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHN---NLSS 280
Query: 252 SANNLFSQSLKYI 264
++LF+ L+Y+
Sbjct: 281 LPHDLFT-PLRYL 292
Score = 64.9 bits (151), Expect = 1e-09
Identities = 55/207 (26%), Positives = 98/207 (47%), Gaps = 6/207 (2%)
Query: 277 KGFPSLRKAI-LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
+G PS + + L N ++ ++++ F + LE L L N+I + F GL L L+L
Sbjct: 71 QGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSC-ELNTIGKD 391
N + VIP + + L +L L N + + R S+ LD+ +L I +
Sbjct: 131 FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEG 190
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
+ EGL ++ L+L + +P+ L+ L ++ N I +F L+ L L V+
Sbjct: 191 AFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDN 478
++ ++I R+ FD L L+L+ N
Sbjct: 251 NSQVSLI-ERNAFDGLASLVELNLAHN 276
Score = 62.5 bits (145), Expect = 5e-09
Identities = 56/204 (27%), Positives = 88/204 (43%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N +R +E AF L L+L +N + + F L L+ L L N I IP
Sbjct: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L Y+S ++ L++ C + + +L L + EL
Sbjct: 166 AFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDM--PNLTPLVGLEEL 223
Query: 403 DLSQNLLSYI-PDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
++S N I P S ++LK L + +++S I F L L L++ N + +
Sbjct: 224 EMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSL-P 282
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F YL L L + W CDC
Sbjct: 283 HDLFTPLRYLVELHLHHDPWNCDC 306
Score = 54.8 bits (126), Expect = 1e-06
Identities = 58/223 (26%), Positives = 104/223 (46%), Gaps = 9/223 (4%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFS-QSLKYID 265
I S+ R L + + + + L L L++ N ++ A N L S +L+ D
Sbjct: 73 IPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFD 132
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIASLRYDTF 324
I + LR+ L +N + + S AF L LDL + + F
Sbjct: 133 NWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAF 192
Query: 325 RGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMS 381
GL LK+L+L I +P +L + L +L++S N+ + G +S + L +
Sbjct: 193 EGLFNLKYLNLGMCNIKDMP--NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL 424
+ +++ I +++ +GL S+VEL+L+ N LS +P + + L+YL
Sbjct: 251 NSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFT-PLRYL 292
Score = 48.8 bits (111), Expect = 7e-05
Identities = 59/204 (28%), Positives = 88/204 (43%), Gaps = 32/204 (15%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCEL 222
LE L L I I + +GL ++ L+L N L I + S LR L++ N +
Sbjct: 101 LEVLQLGRNSIRQIEVGA-FNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNLK---- 277
S+ +PSL L + +LE S +LKY+++ CNI PNL
Sbjct: 160 ESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVG 219
Query: 278 --------------------GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIA 317
G SL+K + ++ V +E NAF L L+L++NN++
Sbjct: 220 LEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLS 279
Query: 318 SLRYDTFRGLKMLKHLDL---SWN 338
SL +D F L+ L L L WN
Sbjct: 280 SLPHDLFTPLRYLVELHLHHDPWN 303
>AF196976-1|AAG28019.2| 653|Homo sapiens brain tumor associated
protein LRRC4 protein.
Length = 653
Score = 67.3 bits (157), Expect = 2e-10
Identities = 65/253 (25%), Positives = 116/253 (45%), Gaps = 33/253 (13%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISS 94
+C C+ + + C+RRGL+++P G+ LN+ N ++ LH+L L +
Sbjct: 49 VCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGR 108
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDL---------- 144
N ++ + A L +L L L FD+WL + P+ + L+ L L
Sbjct: 109 NSIRQIEVGAFNGLASLNTLEL----FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPS 164
Query: 145 -SFNKFQT-----MGNLANQELLIRPSLETLI------LDHCEINSIHGRSPLSGLINIR 192
+FN+ + +G L E + + E L L C I + +PL GL +
Sbjct: 165 YAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELE 224
Query: 193 VLKLNFNPLLRIQNLIS-SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELAS 251
+ +F P +R + SSL+ L+V N +++ + N L SL L +++N L+S
Sbjct: 225 MSGNHF-PEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHN---NLSS 280
Query: 252 SANNLFSQSLKYI 264
++LF+ L+Y+
Sbjct: 281 LPHDLFT-PLRYL 292
Score = 64.9 bits (151), Expect = 1e-09
Identities = 55/207 (26%), Positives = 98/207 (47%), Gaps = 6/207 (2%)
Query: 277 KGFPSLRKAI-LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
+G PS + + L N ++ ++++ F + LE L L N+I + F GL L L+L
Sbjct: 71 QGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSC-ELNTIGKD 391
N + VIP + + L +L L N + + R S+ LD+ +L I +
Sbjct: 131 FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEG 190
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
+ EGL ++ L+L + +P+ L+ L ++ N I +F L+ L L V+
Sbjct: 191 AFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDN 478
++ ++I R+ FD L L+L+ N
Sbjct: 251 NSQVSLI-ERNAFDGLASLVELNLAHN 276
Score = 64.5 bits (150), Expect = 1e-09
Identities = 57/204 (27%), Positives = 88/204 (43%), Gaps = 9/204 (4%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N +R +E AF L L+L +N + + F L L+ L L N I IP
Sbjct: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L Y+S ++ L++ C + + +L L + EL
Sbjct: 166 AFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDM--PNLTPLVGLEEL 223
Query: 403 DLSQNLLSYI-PDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
++S N I P S ++LK L + +++S I F L L L++ N + +
Sbjct: 224 EMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSL-P 282
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F YL L L N W CDC
Sbjct: 283 HDLFTPLRYLVELHLHHNPWNCDC 306
Score = 54.8 bits (126), Expect = 1e-06
Identities = 58/223 (26%), Positives = 104/223 (46%), Gaps = 9/223 (4%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFS-QSLKYID 265
I S+ R L + + + + L L L++ N ++ A N L S +L+ D
Sbjct: 73 IPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFD 132
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIASLRYDTF 324
I + LR+ L +N + + S AF L LDL + + F
Sbjct: 133 NWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAF 192
Query: 325 RGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSMS-VTILDMS 381
GL LK+L+L I +P +L + L +L++S N+ + G +S + L +
Sbjct: 193 EGLFNLKYLNLGMCNIKDMP--NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL 424
+ +++ I +++ +GL S+VEL+L+ N LS +P + + L+YL
Sbjct: 251 NSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFT-PLRYL 292
Score = 49.6 bits (113), Expect = 4e-05
Identities = 58/201 (28%), Positives = 87/201 (43%), Gaps = 29/201 (14%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCEL 222
LE L L I I + +GL ++ L+L N L I + S LR L++ N +
Sbjct: 101 LEVLQLGRNSIRQIEVGA-FNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNLK---- 277
S+ +PSL L + +LE S +LKY+++ CNI PNL
Sbjct: 160 ESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVG 219
Query: 278 --------------------GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIA 317
G SL+K + ++ V +E NAF L L+L++NN++
Sbjct: 220 LEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLS 279
Query: 318 SLRYDTFRGLKMLKHLDLSWN 338
SL +D F L+ L L L N
Sbjct: 280 SLPHDLFTPLRYLVELHLHHN 300
>AY182024-1|AAO67545.1| 522|Homo sapiens leucine-rich repeat
transmembrane neuronal 1 protein protein.
Length = 522
Score = 66.9 bits (156), Expect = 2e-10
Identities = 70/276 (25%), Positives = 115/276 (41%), Gaps = 11/276 (3%)
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL-ASSANNLFSQSLKYIDISY-CN 270
R L+ LT HN L L L + N EL A L + Y+D ++ C+
Sbjct: 48 RLLYCEALNLTEAPHN----LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICS 103
Query: 271 ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
+ + +++ L+ N + L + F L +DLS N + +L D F GL+ L
Sbjct: 104 VQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKL 163
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY---LSRVGHLRSMSVTILDMSSCELNT 387
L + N I +P + SL L + N L+R +T L + +L
Sbjct: 164 TTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVK 223
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIPDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLT 446
+ L S+ L L +N ++ + S+ L+ ++L+ N I + F + L
Sbjct: 224 VNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQ 283
Query: 447 SLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRC 482
SL + NR T I R +S L + L+ N+W C
Sbjct: 284 SLQLDSNRLTYIEPR-ILNSWKSLTSITLAGNLWDC 318
Score = 50.0 bits (114), Expect = 3e-05
Identities = 72/305 (23%), Positives = 123/305 (40%), Gaps = 34/305 (11%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
LCRC + + C LT+ P+ L + L++ N ++ + L L L +
Sbjct: 42 LCRC--EGRLLYCEALNLTEAPHNLS-GLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDH 98
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N + + +A L ++ L LS N PN P +L+ +DLS+NK Q +
Sbjct: 99 NHICSVQGDAFQKLRRVKELTLSSNQITQL----PNTTFRPMPNLRSVDLSYNKLQALA- 153
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
P L HG L+ L ++R + F P+ Q+ SL+
Sbjct: 154 ---------PDL------------FHGLRKLTTL-HMRANAIQFVPVRIFQD--CRSLKF 189
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL-ASSANNLFSQSLKYIDISYCNILQ 273
L + +L SL N L LT L + +N +++ + L S + + I+
Sbjct: 190 LDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVV 249
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
+L +L K L+ N + Y+E + F L+ L L +N + + K L +
Sbjct: 250 SSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSI 309
Query: 334 DLSWN 338
L+ N
Sbjct: 310 TLAGN 314
>AK056644-1|BAB71240.1| 522|Homo sapiens protein ( Homo sapiens
cDNA FLJ32082 fis, clone OCBBF2000231, weakly similar to
PHOSPHOLIPASE A2 INHIBITOR SUBUNIT B PRECURSOR. ).
Length = 522
Score = 66.9 bits (156), Expect = 2e-10
Identities = 70/276 (25%), Positives = 115/276 (41%), Gaps = 11/276 (3%)
Query: 213 RSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL-ASSANNLFSQSLKYIDISY-CN 270
R L+ LT HN L L L + N EL A L + Y+D ++ C+
Sbjct: 48 RLLYCEALNLTEAPHN----LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICS 103
Query: 271 ILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKML 330
+ + +++ L+ N + L + F L +DLS N + +L D F GL+ L
Sbjct: 104 VQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKL 163
Query: 331 KHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNY---LSRVGHLRSMSVTILDMSSCELNT 387
L + N I +P + SL L + N L+R +T L + +L
Sbjct: 164 TTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVK 223
Query: 388 IGKDSLEGLQSIVELDLSQNLLSYIPDSIS-SNTLKYLNLNYNRISSINNLTFFMLNRLT 446
+ L S+ L L +N ++ + S+ L+ ++L+ N I + F + L
Sbjct: 224 VNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQ 283
Query: 447 SLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRC 482
SL + NR T I R +S L + L+ N+W C
Sbjct: 284 SLQLDSNRLTYIEPR-ILNSWKSLTSITLAGNLWDC 318
Score = 50.0 bits (114), Expect = 3e-05
Identities = 72/305 (23%), Positives = 123/305 (40%), Gaps = 34/305 (11%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
LCRC + + C LT+ P+ L + L++ N ++ + L L L +
Sbjct: 42 LCRC--EGRLLYCEALNLTEAPHNLS-GLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDH 98
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N + + +A L ++ L LS N PN P +L+ +DLS+NK Q +
Sbjct: 99 NHICSVQGDAFQKLRRVKELTLSSNQITQL----PNTTFRPMPNLRSVDLSYNKLQALA- 153
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRS 214
P L HG L+ L ++R + F P+ Q+ SL+
Sbjct: 154 ---------PDL------------FHGLRKLTTL-HMRANAIQFVPVRIFQD--CRSLKF 189
Query: 215 LFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLEL-ASSANNLFSQSLKYIDISYCNILQ 273
L + +L SL N L LT L + +N +++ + L S + + I+
Sbjct: 190 LDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVV 249
Query: 274 PNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
+L +L K L+ N + Y+E + F L+ L L +N + + K L +
Sbjct: 250 SSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSI 309
Query: 334 DLSWN 338
L+ N
Sbjct: 310 TLAGN 314
>BC022500-1|AAH22500.1| 557|Homo sapiens leucine-rich, glioma
inactivated 1 protein.
Length = 557
Score = 66.5 bits (155), Expect = 3e-10
Identities = 36/103 (34%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ + I + + PSL+ + N + +AF LEYL + NNNI S+
Sbjct: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
TFRGLK L HL L+ N + +P+D + SLT + L N
Sbjct: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 251 SSANNLFSQSLK---YIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
S + LF+ SL+ + S+ I G P L + +N ++ + + F L
Sbjct: 83 SEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+L L+NNN+ +L D F+GL L ++DL N
Sbjct: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 37.9 bits (84), Expect = 0.13
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMW 480
L+YL + N I SI+ TF L L LS+ N + + F L +DL N +
Sbjct: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSF 175
Query: 481 RCDC 484
CDC
Sbjct: 176 NCDC 179
Score = 35.9 bits (79), Expect = 0.53
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH--LRSMSVTI-LDMSSCELNTIGKDSLE 394
N VI +D+ + +P L L + N + + R + I L +++ L T+ KD +
Sbjct: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160
Query: 395 GLQSIVELDLSQN 407
GL S+ +DL N
Sbjct: 161 GLDSLTNVDLRGN 173
>AY358885-1|AAQ89244.1| 557|Homo sapiens LGI1 protein.
Length = 557
Score = 66.5 bits (155), Expect = 3e-10
Identities = 36/103 (34%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ + I + + PSL+ + N + +AF LEYL + NNNI S+
Sbjct: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
TFRGLK L HL L+ N + +P+D + SLT + L N
Sbjct: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 251 SSANNLFSQSLK---YIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
S + LF+ SL+ + S+ I G P L + +N ++ + + F L
Sbjct: 83 SEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+L L+NNN+ +L D F+GL L ++DL N
Sbjct: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 37.9 bits (84), Expect = 0.13
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMW 480
L+YL + N I SI+ TF L L LS+ N + + F L +DL N +
Sbjct: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSF 175
Query: 481 RCDC 484
CDC
Sbjct: 176 NCDC 179
Score = 35.9 bits (79), Expect = 0.53
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH--LRSMSVTI-LDMSSCELNTIGKDSLE 394
N VI +D+ + +P L L + N + + R + I L +++ L T+ KD +
Sbjct: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160
Query: 395 GLQSIVELDLSQN 407
GL S+ +DL N
Sbjct: 161 GLDSLTNVDLRGN 173
>AY358290-1|AAQ88657.1| 713|Homo sapiens GAC1 protein.
Length = 713
Score = 66.5 bits (155), Expect = 3e-10
Identities = 78/306 (25%), Positives = 140/306 (45%), Gaps = 15/306 (4%)
Query: 192 RVLKLNFNPLLRI-QNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--R 246
+ L L N ++R+ Q+ + ++L L +S + + LP L L + N R
Sbjct: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Query: 247 LELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
LE S A Q L Y++ + + P G +L + LN N++R ++S F
Sbjct: 132 LEDHSFAGLASLQEL-YLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPN 190
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N + ++ FR L L+ L L+ + I + +L + SL L N L+
Sbjct: 191 LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLA 250
Query: 366 RVGH--LRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLS--QNLLSYIPDS-ISSN 419
RV L + + LD++ L +G + + EL L+ + L+S + ++
Sbjct: 251 RVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLP 310
Query: 420 TLKYLNLNYN-RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L L++ N R+S I+ F L ++ +L + N + + +++ +S P L+ + L N
Sbjct: 311 ELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQT-VESLPNLQEVGLHGN 369
Query: 479 MWRCDC 484
RCDC
Sbjct: 370 PIRCDC 375
Score = 59.7 bits (138), Expect = 4e-08
Identities = 63/238 (26%), Positives = 120/238 (50%), Gaps = 20/238 (8%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L +++N+ + P + S L NL+ L ++SN L+ + L LE+L + N D+
Sbjct: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
L++N P +L+ L L+ + + + A + L SLE+L ++ + R+
Sbjct: 205 LDMN----FRPLANLRSLVLAGMNLREISDYALEGL---QSLESLSFYDNQLARVPRRA- 256
Query: 185 LSGLINIRVLKLNFNPLLRI-----QNLISSSLRSLFVSNC-ELTSLNHNELMFLPSLTH 238
L + ++ L LN NPL R+ N++ L+ L ++N EL S++ L+ LP LT
Sbjct: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANML--HLKELGLNNMEELVSIDKFALVNLPELTK 314
Query: 239 LKMSNNYRLEL--ASSANNLFSQSLKYIDISYCNIL-QPNLKGFPSLRKAILNHNMVR 293
L ++NN RL + ++L ++ + + L Q ++ P+L++ L+ N +R
Sbjct: 315 LDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIR 372
Score = 58.0 bits (134), Expect = 1e-07
Identities = 79/324 (24%), Positives = 136/324 (41%), Gaps = 26/324 (8%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGL 100
+ T +DC+ LT +P L L + +N + +S L L NL LD+S N
Sbjct: 49 EATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDA 108
Query: 101 PDNALYNLTALEVLNLSRNYF-----DSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
D + L L L+L N S+ L L H ++ ++ F + NL
Sbjct: 109 RDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELY-LNHNQLYRIAPRAFSGLSNL 167
Query: 156 ----ANQELL---------IRPSLETLILDHCEINSIHGRS--PLSGLINIRVLKLNFNP 200
N LL + P+LE L++ ++++I + PL+ L ++ + +N
Sbjct: 168 LRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLRE 227
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN--YRLELASSANNLFS 258
+ SL SL + +L + L +P L L ++ N R+ AN L
Sbjct: 228 ISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHL 287
Query: 259 QSLKYIDI-SYCNILQPNLKGFPSLRKA-ILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+ L ++ +I + L P L K I N+ + ++ AF + ++E L L+NN +
Sbjct: 288 KELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNAL 347
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEI 340
++L T L L+ + L N I
Sbjct: 348 SALHQQTVESLPNLQEVGLHGNPI 371
>AL512306-1|CAI14096.1| 713|Homo sapiens leucine rich repeat
neuronal 5 protein.
Length = 713
Score = 66.5 bits (155), Expect = 3e-10
Identities = 78/306 (25%), Positives = 140/306 (45%), Gaps = 15/306 (4%)
Query: 192 RVLKLNFNPLLRI-QNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--R 246
+ L L N ++R+ Q+ + ++L L +S + + LP L L + N R
Sbjct: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Query: 247 LELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
LE S A Q L Y++ + + P G +L + LN N++R ++S F
Sbjct: 132 LEDHSFAGLASLQEL-YLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPN 190
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N + ++ FR L L+ L L+ + I + +L + SL L N L+
Sbjct: 191 LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLA 250
Query: 366 RVGH--LRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLS--QNLLSYIPDS-ISSN 419
RV L + + LD++ L +G + + EL L+ + L+S + ++
Sbjct: 251 RVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLP 310
Query: 420 TLKYLNLNYN-RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L L++ N R+S I+ F L ++ +L + N + + +++ +S P L+ + L N
Sbjct: 311 ELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQT-VESLPNLQEVGLHGN 369
Query: 479 MWRCDC 484
RCDC
Sbjct: 370 PIRCDC 375
Score = 59.7 bits (138), Expect = 4e-08
Identities = 63/238 (26%), Positives = 120/238 (50%), Gaps = 20/238 (8%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L +++N+ + P + S L NL+ L ++SN L+ + L LE+L + N D+
Sbjct: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
L++N P +L+ L L+ + + + A + L SLE+L ++ + R+
Sbjct: 205 LDMN----FRPLANLRSLVLAGMNLREISDYALEGL---QSLESLSFYDNQLARVPRRA- 256
Query: 185 LSGLINIRVLKLNFNPLLRI-----QNLISSSLRSLFVSNC-ELTSLNHNELMFLPSLTH 238
L + ++ L LN NPL R+ N++ L+ L ++N EL S++ L+ LP LT
Sbjct: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANML--HLKELGLNNMEELVSIDKFALVNLPELTK 314
Query: 239 LKMSNNYRLEL--ASSANNLFSQSLKYIDISYCNIL-QPNLKGFPSLRKAILNHNMVR 293
L ++NN RL + ++L ++ + + L Q ++ P+L++ L+ N +R
Sbjct: 315 LDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIR 372
Score = 58.0 bits (134), Expect = 1e-07
Identities = 79/324 (24%), Positives = 136/324 (41%), Gaps = 26/324 (8%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGL 100
+ T +DC+ LT +P L L + +N + +S L L NL LD+S N
Sbjct: 49 EATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDA 108
Query: 101 PDNALYNLTALEVLNLSRNYF-----DSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
D + L L L+L N S+ L L H ++ ++ F + NL
Sbjct: 109 RDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELY-LNHNQLYRIAPRAFSGLSNL 167
Query: 156 ----ANQELL---------IRPSLETLILDHCEINSIHGRS--PLSGLINIRVLKLNFNP 200
N LL + P+LE L++ ++++I + PL+ L ++ + +N
Sbjct: 168 LRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLRE 227
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN--YRLELASSANNLFS 258
+ SL SL + +L + L +P L L ++ N R+ AN L
Sbjct: 228 ISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHL 287
Query: 259 QSLKYIDI-SYCNILQPNLKGFPSLRKA-ILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+ L ++ +I + L P L K I N+ + ++ AF + ++E L L+NN +
Sbjct: 288 KELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNAL 347
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEI 340
++L T L L+ + L N I
Sbjct: 348 SALHQQTVESLPNLQEVGLHGNPI 371
>AL358154-2|CAI14982.1| 557|Homo sapiens leucine-rich, glioma
inactivated 1 protein.
Length = 557
Score = 66.5 bits (155), Expect = 3e-10
Identities = 36/103 (34%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ + I + + PSL+ + N + +AF LEYL + NNNI S+
Sbjct: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
TFRGLK L HL L+ N + +P+D + SLT + L N
Sbjct: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 251 SSANNLFSQSLK---YIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
S + LF+ SL+ + S+ I G P L + +N ++ + + F L
Sbjct: 83 SEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+L L+NNN+ +L D F+GL L ++DL N
Sbjct: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 37.9 bits (84), Expect = 0.13
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMW 480
L+YL + N I SI+ TF L L LS+ N + + F L +DL N +
Sbjct: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSF 175
Query: 481 RCDC 484
CDC
Sbjct: 176 NCDC 179
Score = 35.9 bits (79), Expect = 0.53
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH--LRSMSVTI-LDMSSCELNTIGKDSLE 394
N VI +D+ + +P L L + N + + R + I L +++ L T+ KD +
Sbjct: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160
Query: 395 GLQSIVELDLSQN 407
GL S+ +DL N
Sbjct: 161 GLDSLTNVDLRGN 173
>AL358154-1|CAI14981.1| 291|Homo sapiens leucine-rich, glioma
inactivated 1 protein.
Length = 291
Score = 66.5 bits (155), Expect = 3e-10
Identities = 36/103 (34%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ + I + + PSL+ + N + +AF LEYL + NNNI S+
Sbjct: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
TFRGLK L HL L+ N + +P+D + SLT + L N
Sbjct: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 251 SSANNLFSQSLK---YIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
S + LF+ SL+ + S+ I G P L + +N ++ + + F L
Sbjct: 83 SEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+L L+NNN+ +L D F+GL L ++DL N
Sbjct: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 37.9 bits (84), Expect = 0.13
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMW 480
L+YL + N I SI+ TF L L LS+ N + + F L +DL N +
Sbjct: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSF 175
Query: 481 RCDC 484
CDC
Sbjct: 176 NCDC 179
Score = 35.9 bits (79), Expect = 0.53
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH--LRSMSVTI-LDMSSCELNTIGKDSLE 394
N VI +D+ + +P L L + N + + R + I L +++ L T+ KD +
Sbjct: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160
Query: 395 GLQSIVELDLSQN 407
GL S+ +DL N
Sbjct: 161 GLDSLTNVDLRGN 173
>AL157396-3|CAH73838.1| 557|Homo sapiens leucine-rich, glioma
inactivated 1 protein.
Length = 557
Score = 66.5 bits (155), Expect = 3e-10
Identities = 36/103 (34%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ + I + + PSL+ + N + +AF LEYL + NNNI S+
Sbjct: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
TFRGLK L HL L+ N + +P+D + SLT + L N
Sbjct: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 251 SSANNLFSQSLK---YIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
S + LF+ SL+ + S+ I G P L + +N ++ + + F L
Sbjct: 83 SEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+L L+NNN+ +L D F+GL L ++DL N
Sbjct: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 37.9 bits (84), Expect = 0.13
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMW 480
L+YL + N I SI+ TF L L LS+ N + + F L +DL N +
Sbjct: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSF 175
Query: 481 RCDC 484
CDC
Sbjct: 176 NCDC 179
Score = 35.9 bits (79), Expect = 0.53
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH--LRSMSVTI-LDMSSCELNTIGKDSLE 394
N VI +D+ + +P L L + N + + R + I L +++ L T+ KD +
Sbjct: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160
Query: 395 GLQSIVELDLSQN 407
GL S+ +DL N
Sbjct: 161 GLDSLTNVDLRGN 173
>AL157396-2|CAH73837.1| 291|Homo sapiens leucine-rich, glioma
inactivated 1 protein.
Length = 291
Score = 66.5 bits (155), Expect = 3e-10
Identities = 36/103 (34%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ + I + + PSL+ + N + +AF LEYL + NNNI S+
Sbjct: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
TFRGLK L HL L+ N + +P+D + SLT + L N
Sbjct: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 251 SSANNLFSQSLK---YIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
S + LF+ SL+ + S+ I G P L + +N ++ + + F L
Sbjct: 83 SEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+L L+NNN+ +L D F+GL L ++DL N
Sbjct: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 37.9 bits (84), Expect = 0.13
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMW 480
L+YL + N I SI+ TF L L LS+ N + + F L +DL N +
Sbjct: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSF 175
Query: 481 RCDC 484
CDC
Sbjct: 176 NCDC 179
Score = 35.9 bits (79), Expect = 0.53
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH--LRSMSVTI-LDMSSCELNTIGKDSLE 394
N VI +D+ + +P L L + N + + R + I L +++ L T+ KD +
Sbjct: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160
Query: 395 GLQSIVELDLSQN 407
GL S+ +DL N
Sbjct: 161 GLDSLTNVDLRGN 173
>AF473548-1|AAM22074.1| 291|Homo sapiens leucine-rich glioma
inactivated-1 protein.
Length = 291
Score = 66.5 bits (155), Expect = 3e-10
Identities = 36/103 (34%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ + I + + PSL+ + N + +AF LEYL + NNNI S+
Sbjct: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
TFRGLK L HL L+ N + +P+D + SLT + L N
Sbjct: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 251 SSANNLFSQSLK---YIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
S + LF+ SL+ + S+ I G P L + +N ++ + + F L
Sbjct: 83 SEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+L L+NNN+ +L D F+GL L ++DL N
Sbjct: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 37.9 bits (84), Expect = 0.13
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMW 480
L+YL + N I SI+ TF L L LS+ N + + F L +DL N +
Sbjct: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSF 175
Query: 481 RCDC 484
CDC
Sbjct: 176 NCDC 179
Score = 35.9 bits (79), Expect = 0.53
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH--LRSMSVTI-LDMSSCELNTIGKDSLE 394
N VI +D+ + +P L L + N + + R + I L +++ L T+ KD +
Sbjct: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160
Query: 395 GLQSIVELDLSQN 407
GL S+ +DL N
Sbjct: 161 GLDSLTNVDLRGN 173
>AF055636-1|AAC99316.1| 557|Homo sapiens leucine-rich
glioma-inactivated protein precursor protein.
Length = 557
Score = 66.5 bits (155), Expect = 3e-10
Identities = 36/103 (34%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ + I + + PSL+ + N + +AF LEYL + NNNI S+
Sbjct: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
TFRGLK L HL L+ N + +P+D + SLT + L N
Sbjct: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 251 SSANNLFSQSLK---YIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELE 307
S + LF+ SL+ + S+ I G P L + +N ++ + + F L
Sbjct: 83 SEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142
Query: 308 YLDLSNNNIASLRYDTFRGLKMLKHLDLSWN 338
+L L+NNN+ +L D F+GL L ++DL N
Sbjct: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173
Score = 37.9 bits (84), Expect = 0.13
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 421 LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMW 480
L+YL + N I SI+ TF L L LS+ N + + F L +DL N +
Sbjct: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSF 175
Query: 481 RCDC 484
CDC
Sbjct: 176 NCDC 179
Score = 35.9 bits (79), Expect = 0.53
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGH--LRSMSVTI-LDMSSCELNTIGKDSLE 394
N VI +D+ + +P L L + N + + R + I L +++ L T+ KD +
Sbjct: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160
Query: 395 GLQSIVELDLSQN 407
GL S+ +DL N
Sbjct: 161 GLDSLTNVDLRGN 173
>AF030435-1|AAC39792.1| 713|Homo sapiens glioma amplified on
chromosome 1 protein protein.
Length = 713
Score = 66.5 bits (155), Expect = 3e-10
Identities = 78/306 (25%), Positives = 140/306 (45%), Gaps = 15/306 (4%)
Query: 192 RVLKLNFNPLLRI-QNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--R 246
+ L L N ++R+ Q+ + ++L L +S + + LP L L + N R
Sbjct: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Query: 247 LELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
LE S A Q L Y++ + + P G +L + LN N++R ++S F
Sbjct: 132 LEDHSFAGLASLQEL-YLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPN 190
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N + ++ FR L L+ L L+ + I + +L + SL L N L+
Sbjct: 191 LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLA 250
Query: 366 RVGH--LRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLS--QNLLSYIPDS-ISSN 419
RV L + + LD++ L +G + + EL L+ + L+S + ++
Sbjct: 251 RVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLP 310
Query: 420 TLKYLNLNYN-RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L L++ N R+S I+ F L ++ +L + N + + +++ +S P L+ + L N
Sbjct: 311 ELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQT-VESLPNLQEVGLHGN 369
Query: 479 MWRCDC 484
RCDC
Sbjct: 370 PIRCDC 375
Score = 59.7 bits (138), Expect = 4e-08
Identities = 63/238 (26%), Positives = 120/238 (50%), Gaps = 20/238 (8%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L +++N+ + P + S L NL+ L ++SN L+ + L LE+L + N D+
Sbjct: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
L++N P +L+ L L+ + + + A + L SLE+L ++ + R+
Sbjct: 205 LDMN----FRPLANLRSLVLAGMNLREISDYALEGL---QSLESLSFYDNQLARVPRRA- 256
Query: 185 LSGLINIRVLKLNFNPLLRI-----QNLISSSLRSLFVSNC-ELTSLNHNELMFLPSLTH 238
L + ++ L LN NPL R+ N++ L+ L ++N EL S++ L+ LP LT
Sbjct: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANML--HLKELGLNNMEELVSIDKFALVNLPELTK 314
Query: 239 LKMSNNYRLEL--ASSANNLFSQSLKYIDISYCNIL-QPNLKGFPSLRKAILNHNMVR 293
L ++NN RL + ++L ++ + + L Q ++ P+L++ L+ N +R
Sbjct: 315 LDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIR 372
Score = 58.0 bits (134), Expect = 1e-07
Identities = 79/324 (24%), Positives = 136/324 (41%), Gaps = 26/324 (8%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGL 100
+ T +DC+ LT +P L L + +N + +S L L NL LD+S N
Sbjct: 49 EATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDA 108
Query: 101 PDNALYNLTALEVLNLSRNYF-----DSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
D + L L L+L N S+ L L H ++ ++ F + NL
Sbjct: 109 RDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELY-LNHNQLYRIAPRAFSGLSNL 167
Query: 156 ----ANQELL---------IRPSLETLILDHCEINSIHGRS--PLSGLINIRVLKLNFNP 200
N LL + P+LE L++ ++++I + PL+ L ++ + +N
Sbjct: 168 LRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLRE 227
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN--YRLELASSANNLFS 258
+ SL SL + +L + L +P L L ++ N R+ AN L
Sbjct: 228 ISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHL 287
Query: 259 QSLKYIDI-SYCNILQPNLKGFPSLRKA-ILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+ L ++ +I + L P L K I N+ + ++ AF + ++E L L+NN +
Sbjct: 288 KELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNAL 347
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEI 340
++L T L L+ + L N I
Sbjct: 348 SALHQQTVESLPNLQEVGLHGNPI 371
>AB011537-1|BAA32465.3| 1618|Homo sapiens MEGF4 protein.
Length = 1618
Score = 66.5 bits (155), Expect = 3e-10
Identities = 44/152 (28%), Positives = 78/152 (51%), Gaps = 5/152 (3%)
Query: 307 EYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR 366
E L+L+ NNI + + F GLK L+ L L N+I V+ + +M L +L+L+RN L
Sbjct: 148 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGVVERGAFDDMKELERLRLNRNQLHM 207
Query: 367 VGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTL 421
+ L + +++ LD+S + I + + G + L L +N +S I + + L
Sbjct: 208 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 267
Query: 422 KYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
+ L LN N I++I +F + +L + + N
Sbjct: 268 EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSN 299
Score = 58.0 bits (134), Expect = 1e-07
Identities = 74/320 (23%), Positives = 139/320 (43%), Gaps = 21/320 (6%)
Query: 66 KLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN----- 119
K+N+SNN+ ++ + + ++ L +++NQL+ + L L L L N
Sbjct: 653 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 712
Query: 120 YFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSI 179
+ DS+ L N LL +I +S F T+ +L+ LL P +C++ +
Sbjct: 713 HNDSFTGLR-NVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANP-----FNCNCQLAWL 766
Query: 180 HGRSPLSGLI--NIRVLKLNFNPLLRIQNLISSSLR---SLFVSNCELTSLNHNELMFLP 234
G ++ N R +F + +Q++ R C E L
Sbjct: 767 GGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLD 826
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRY 294
++ ++ SN + L ++ Y+D + ++ L F L+ L++N +
Sbjct: 827 TV--VRCSNKHLRALPKGIPKNVTEL--YLDGNQFTLVPGQLSTFKYLQLVDLSNNKISS 882
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
L +++F N ++L L LS N + + F+GL+ L+ L L N+I+ + E ++ SL
Sbjct: 883 LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSL 942
Query: 355 TQLKLSRNYLSRVGHLRSMS 374
+ L + N L HLR +S
Sbjct: 943 SHLAIGANPLYCDCHLRWLS 962
Score = 55.6 bits (128), Expect = 6e-07
Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 3/128 (2%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
+L + L+ N ++ + AF T+L+ L L N I+ + FR L+ L+ L L+ N I
Sbjct: 218 ALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNI 277
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT--IGKDSLEGLQS 398
IP S MP L +L N+L HL +S + + L T G SL GL +
Sbjct: 278 TTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGL-N 336
Query: 399 IVELDLSQ 406
+ E+ S+
Sbjct: 337 VAEVQKSE 344
Score = 55.6 bits (128), Expect = 6e-07
Identities = 101/405 (24%), Positives = 176/405 (43%), Gaps = 37/405 (9%)
Query: 99 GLPDNALYNLTALEVLNLSRNYFDSWLNLN-----PNDVLLPATHLKILDLSFNKFQTMG 153
G+ D LTA+ NL + L LN P P L+ +DLS N+ +
Sbjct: 375 GIVDCRGKGLTAIPA-NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIA 433
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
A Q L SL +L+L +I + R GL +++L LN N +I + + +
Sbjct: 434 PDAFQGLR---SLNSLVLYGNKITDLP-RGVFGGLYTLQLLLLNAN---KINCIRPDAFQ 486
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYI-DISYCNIL 272
L N L SL N++ L T + L LA + + +LK++ D N +
Sbjct: 487 DL--QNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF-ICDCNLKWLADFLRTNPI 543
Query: 273 QPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI---ASLRYDTFRGLKM 329
+ + S R+ L + + ++S F + + +Y + + D K
Sbjct: 544 ETSGARCASPRR--LANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKC 601
Query: 330 ---LKHLDLSWNEIAVIPEDSLLEMPSLT-QLKLSRNYLS---RVGHLRSMS-VTILDMS 381
++ S ++ IPE +P T +L+L+ N +S G + ++ + +++S
Sbjct: 602 RCEANVVECSSLKLTKIPE----RIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLS 657
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTF 439
+ +++ I + EG S+ EL L+ N L I + + L+ L L NRIS I+N +F
Sbjct: 658 NNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSF 717
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
L + LS+ N+ T + FD+ L L+L N + C+C
Sbjct: 718 TGLRNVRLLSLYDNQITTV-SPGAFDTLQSLSTLNLLANPFNCNC 761
Score = 54.0 bits (124), Expect = 2e-06
Identities = 30/83 (36%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQ 96
C C LD T + CS + L +P G+ VT+L + N+FT P LS L +D+S+N+
Sbjct: 822 CAC-LD-TVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNK 879
Query: 97 LKGLPDNALYNLTALEVLNLSRN 119
+ L +++ N++ L L LS N
Sbjct: 880 ISSLSNSSFTNMSQLTTLILSYN 902
Score = 53.6 bits (123), Expect = 2e-06
Identities = 35/117 (29%), Positives = 63/117 (53%), Gaps = 3/117 (2%)
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSIN 435
+D+S+ ++ I D+ +GL+S+ L L N ++ +P + TL+ L LN N+I+ I
Sbjct: 422 IDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIR 481
Query: 436 NLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDF 492
F L L+ LS+ N+ + + F S ++ L L+ N + CDC+ + + DF
Sbjct: 482 PDAFQDLQNLSLLSLYDNKIQSL-AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADF 537
Score = 52.0 bits (119), Expect = 8e-06
Identities = 30/86 (34%), Positives = 43/86 (50%)
Query: 282 LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIA 341
L + LN N + L F NN L LDLS N I ++ FRG LK+L L N+I+
Sbjct: 195 LERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS 254
Query: 342 VIPEDSLLEMPSLTQLKLSRNYLSRV 367
I E + + L L L+ N ++ +
Sbjct: 255 CIEEGAFRALRGLEVLTLNNNNITTI 280
Score = 51.6 bits (118), Expect = 1e-05
Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 3/135 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G LR L N + +E AF + ELE L L+ N + L F+ + L LDLS
Sbjct: 167 GLKQLRVLQLMENQIGVVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSE 226
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLE 394
N I IP + L L+L +N +S + G R++ + +L +++ + TI S
Sbjct: 227 NAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN 286
Query: 395 GLQSIVELDLSQNLL 409
+ + L N L
Sbjct: 287 HMPKLRTFRLHSNHL 301
Score = 50.0 bits (114), Expect = 3e-05
Identities = 85/370 (22%), Positives = 158/370 (42%), Gaps = 32/370 (8%)
Query: 57 PNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYN-LTALEVLN 115
P+ + + S+ + TK PE + + + L +++N++ L ++ LT L+ +N
Sbjct: 598 PHKCRCEANVVECSSLKLTKIPERIPQ--STAELRLNNNEISILEATGMFKKLTHLKKIN 655
Query: 116 LSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
LS N + A + L L+ N+ +++ + + L L TL+L +
Sbjct: 656 LSNNKVSEI----EDGAFEGAASVSELHLTANQLESIRSGMFRGL---DGLRTLMLRNNR 708
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHN-ELMFLP 234
I+ IH S +GL N+R+L L N + + +L+SL N N N +L +L
Sbjct: 709 ISCIHNDS-FTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLG 767
Query: 235 SLTHLK--MSNNYRLELASSANNLFSQSLKYIDISYCN--------ILQPNLKGFPSLRK 284
+ ++ N R + + Q + + D C + +P +
Sbjct: 768 GWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR-CEEGQEEGGCLPRPQCPQECACLD 826
Query: 285 AIL--NHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAV 342
++ ++ +R L N TEL YLD + + + TF K L+ +DLS N+I+
Sbjct: 827 TVVRCSNKHLRALPKGIPKNVTEL-YLDGNQFTLVPGQLSTF---KYLQLVDLSNNKISS 882
Query: 343 IPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM---SVTILDMSSCELNTIGKDSLEGLQSI 399
+ S M LT L LS N L + L S+ +L + +++T+ + + S+
Sbjct: 883 LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSL 942
Query: 400 VELDLSQNLL 409
L + N L
Sbjct: 943 SHLAIGANPL 952
Score = 48.4 bits (110), Expect = 9e-05
Identities = 48/170 (28%), Positives = 73/170 (42%), Gaps = 11/170 (6%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
LC C T +DC GL IP + +L ++ N T+ ++ + L L L +
Sbjct: 121 LCTCT--GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLME 178
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
NQ+ + A ++ LE L L+RN L++ P + L LDLS N Q +
Sbjct: 179 NQIGVVERGAFDDMKELERLRLNRNQ----LHMLPELLFQNNQALSRLDLSENAIQAIPR 234
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI 204
A + L+ L LD +I+ I L + VL LN N + I
Sbjct: 235 KAFRG---ATDLKNLQLDKNQISCIE-EGAFRALRGLEVLTLNNNNITTI 280
Score = 46.0 bits (104), Expect = 5e-04
Identities = 47/170 (27%), Positives = 73/170 (42%), Gaps = 9/170 (5%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL 97
C +DC +GLT IP L +T++ + N P + S L +D+S+NQ+
Sbjct: 370 CTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQI 429
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLAN 157
+ +A L +L L L N P V L++L L+ NK + A
Sbjct: 430 AEIAPDAFQGLRSLNSLVLYGNKITDL----PRGVFGGLYTLQLLLLNANKINCIRPDAF 485
Query: 158 QELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNL 207
Q+L +L L L +I S+ + + L I+ L L NP + NL
Sbjct: 486 QDL---QNLSLLSLYDNKIQSL-AKGTFTSLRAIQTLHLAQNPFICDCNL 531
Score = 44.8 bits (101), Expect = 0.001
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 20/174 (11%)
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLN 226
E L L+ I IH ++ +GL +RVL+L N + ++ ++ L E LN
Sbjct: 148 ERLELNGNNITRIH-KNDFAGLKQLRVLQLMENQIGVVERGAFDDMKEL-----ERLRLN 201
Query: 227 HNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI 286
N+L LP L RL+L+ +A + +G L+
Sbjct: 202 RNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKA--------------FRGATDLKNLQ 247
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
L+ N + +E AF LE L L+NNNI ++ +F + L+ L N +
Sbjct: 248 LDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 301
Score = 42.7 bits (96), Expect = 0.005
Identities = 21/88 (23%), Positives = 45/88 (51%), Gaps = 2/88 (2%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES--LSRLHNLVNLDISSN 95
+C + ++CS LT IP + +L ++NNE + + +L +L +++S+N
Sbjct: 600 KCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNN 659
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDS 123
++ + D A ++ L+L+ N +S
Sbjct: 660 KVSEIEDGAFEGAASVSELHLTANQLES 687
>BC068541-1|AAH68541.1| 713|Homo sapiens leucine rich repeat
neuronal 2 protein.
Length = 713
Score = 66.1 bits (154), Expect = 4e-10
Identities = 78/306 (25%), Positives = 140/306 (45%), Gaps = 15/306 (4%)
Query: 192 RVLKLNFNPLLRI-QNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--R 246
+ L L N ++R+ Q+ + ++L L +S + + LP L L + N R
Sbjct: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Query: 247 LELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
LE S A Q L Y++ + + P G +L + LN N++R ++S F
Sbjct: 132 LEDHSFAGLASLQEL-YLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPN 190
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N + ++ FR L L+ L L+ + I + +L + SL L N L+
Sbjct: 191 LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLA 250
Query: 366 RVGH--LRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLS--QNLLSYIPDS-ISSN 419
RV L + + LD++ L +G + + EL L+ + L+S + ++
Sbjct: 251 RVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLP 310
Query: 420 TLKYLNLNYN-RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L L++ N R+S I+ F L ++ +L + N + + +++ +S P L+ + L N
Sbjct: 311 ELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQT-AESLPNLQEVGLHGN 369
Query: 479 MWRCDC 484
RCDC
Sbjct: 370 PIRCDC 375
Score = 58.8 bits (136), Expect = 7e-08
Identities = 63/238 (26%), Positives = 119/238 (50%), Gaps = 20/238 (8%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L +++N+ + P + S L NL+ L ++SN L+ + L LE+L + N D+
Sbjct: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
L++N P +L+ L L+ + + + A + L SLE+L ++ + R+
Sbjct: 205 LDMN----FRPLANLRSLVLAGMNLREISDYALEGL---QSLESLSFYDNQLARVPRRA- 256
Query: 185 LSGLINIRVLKLNFNPLLRI-----QNLISSSLRSLFVSNC-ELTSLNHNELMFLPSLTH 238
L + ++ L LN NPL R+ N++ L+ L ++N EL S++ L+ LP LT
Sbjct: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANML--HLKELGLNNMEELVSIDKFALVNLPELTK 314
Query: 239 LKMSNNYRLEL--ASSANNLFSQSLKYIDISYCNIL-QPNLKGFPSLRKAILNHNMVR 293
L ++NN RL + ++L ++ + + L Q + P+L++ L+ N +R
Sbjct: 315 LDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTAESLPNLQEVGLHGNPIR 372
Score = 57.6 bits (133), Expect = 2e-07
Identities = 79/324 (24%), Positives = 136/324 (41%), Gaps = 26/324 (8%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGL 100
+ T +DC+ LT +P L L + +N + +S L L NL LD+S N
Sbjct: 49 EATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDA 108
Query: 101 PDNALYNLTALEVLNLSRNYF-----DSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
D + L L L+L N S+ L L H ++ ++ F + NL
Sbjct: 109 RDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELY-LNHNQLYRIAPRAFSGLSNL 167
Query: 156 ----ANQELL---------IRPSLETLILDHCEINSIHGRS--PLSGLINIRVLKLNFNP 200
N LL + P+LE L++ ++++I + PL+ L ++ + +N
Sbjct: 168 LRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLRE 227
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN--YRLELASSANNLFS 258
+ SL SL + +L + L +P L L ++ N R+ AN L
Sbjct: 228 ISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHL 287
Query: 259 QSLKYIDI-SYCNILQPNLKGFPSLRKA-ILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+ L ++ +I + L P L K I N+ + ++ AF + ++E L L+NN +
Sbjct: 288 KELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNAL 347
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEI 340
++L T L L+ + L N I
Sbjct: 348 SALHQQTAESLPNLQEVGLHGNPI 371
>BC034047-1|AAH34047.1| 713|Homo sapiens leucine rich repeat
neuronal 2 protein.
Length = 713
Score = 66.1 bits (154), Expect = 4e-10
Identities = 78/306 (25%), Positives = 140/306 (45%), Gaps = 15/306 (4%)
Query: 192 RVLKLNFNPLLRI-QNLIS--SSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNY--R 246
+ L L N ++R+ Q+ + ++L L +S + + LP L L + N R
Sbjct: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Query: 247 LELASSANNLFSQSLKYIDISYCNILQPN-LKGFPSLRKAILNHNMVRYLESNAFANNTE 305
LE S A Q L Y++ + + P G +L + LN N++R ++S F
Sbjct: 132 LEDHSFAGLASLQEL-YLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPN 190
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
LE L + N + ++ FR L L+ L L+ + I + +L + SL L N L+
Sbjct: 191 LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLA 250
Query: 366 RVGH--LRSM-SVTILDMSSCELNTIGKDSLEGLQSIVELDLS--QNLLSYIPDS-ISSN 419
RV L + + LD++ L +G + + EL L+ + L+S + ++
Sbjct: 251 RVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLP 310
Query: 420 TLKYLNLNYN-RISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L L++ N R+S I+ F L ++ +L + N + + +++ +S P L+ + L N
Sbjct: 311 ELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQT-AESLPNLQEVGLHGN 369
Query: 479 MWRCDC 484
RCDC
Sbjct: 370 PIRCDC 375
Score = 58.8 bits (136), Expect = 7e-08
Identities = 63/238 (26%), Positives = 119/238 (50%), Gaps = 20/238 (8%)
Query: 66 KLNISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSW 124
+L +++N+ + P + S L NL+ L ++SN L+ + L LE+L + N D+
Sbjct: 145 ELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAI 204
Query: 125 LNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSP 184
L++N P +L+ L L+ + + + A + L SLE+L ++ + R+
Sbjct: 205 LDMN----FRPLANLRSLVLAGMNLREISDYALEGL---QSLESLSFYDNQLARVPRRA- 256
Query: 185 LSGLINIRVLKLNFNPLLRI-----QNLISSSLRSLFVSNC-ELTSLNHNELMFLPSLTH 238
L + ++ L LN NPL R+ N++ L+ L ++N EL S++ L+ LP LT
Sbjct: 257 LEQVPGLKFLDLNKNPLQRVGPGDFANML--HLKELGLNNMEELVSIDKFALVNLPELTK 314
Query: 239 LKMSNNYRLEL--ASSANNLFSQSLKYIDISYCNIL-QPNLKGFPSLRKAILNHNMVR 293
L ++NN RL + ++L ++ + + L Q + P+L++ L+ N +R
Sbjct: 315 LDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTAESLPNLQEVGLHGNPIR 372
Score = 57.6 bits (133), Expect = 2e-07
Identities = 79/324 (24%), Positives = 136/324 (41%), Gaps = 26/324 (8%)
Query: 42 DKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISSNQLKGL 100
+ T +DC+ LT +P L L + +N + +S L L NL LD+S N
Sbjct: 49 EATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDA 108
Query: 101 PDNALYNLTALEVLNLSRNYF-----DSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNL 155
D + L L L+L N S+ L L H ++ ++ F + NL
Sbjct: 109 RDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELY-LNHNQLYRIAPRAFSGLSNL 167
Query: 156 ----ANQELL---------IRPSLETLILDHCEINSIHGRS--PLSGLINIRVLKLNFNP 200
N LL + P+LE L++ ++++I + PL+ L ++ + +N
Sbjct: 168 LRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLRE 227
Query: 201 LLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNN--YRLELASSANNLFS 258
+ SL SL + +L + L +P L L ++ N R+ AN L
Sbjct: 228 ISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHL 287
Query: 259 QSLKYIDI-SYCNILQPNLKGFPSLRKA-ILNHNMVRYLESNAFANNTELEYLDLSNNNI 316
+ L ++ +I + L P L K I N+ + ++ AF + ++E L L+NN +
Sbjct: 288 KELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNAL 347
Query: 317 ASLRYDTFRGLKMLKHLDLSWNEI 340
++L T L L+ + L N I
Sbjct: 348 SALHQQTAESLPNLQEVGLHGNPI 371
>AJ297858-1|CAC82651.1| 649|Homo sapiens hypothetical protein
protein.
Length = 649
Score = 66.1 bits (154), Expect = 4e-10
Identities = 55/234 (23%), Positives = 98/234 (41%), Gaps = 9/234 (3%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKF-PESLSRLHNLVNLDISS 94
+C C+ + + C+RRGL+++P G+ LN+ N ++ LH+L L +
Sbjct: 49 VCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGR 108
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
N ++ + A L +L L L FD+WL + P+ + L+ L L N +++ +
Sbjct: 109 NSIRQIEVGAFNGLASLNTLEL----FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPS 164
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLIS-SSLR 213
A + PSL L L + GL N++ L L + + NL L
Sbjct: 165 YAFNRV---PSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLE 221
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDIS 267
L +S + L SL L + N++ +L +L + ++S
Sbjct: 222 ELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSHERNAFDGLASLVELNLAHNNLS 275
Score = 58.8 bits (136), Expect = 7e-08
Identities = 54/207 (26%), Positives = 94/207 (45%), Gaps = 10/207 (4%)
Query: 277 KGFPSLRKAI-LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDL 335
+G PS + + L N ++ ++++ F + LE L L N+I + F GL L L+L
Sbjct: 71 QGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 130
Query: 336 SWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRV---GHLRSMSVTILDMSSC-ELNTIGKD 391
N + VIP + + L +L L N + + R S+ LD+ +L I +
Sbjct: 131 FDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEG 190
Query: 392 SLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVV 451
+ EGL ++ L+L + +P+ L+ L ++ N I +F L+ L L V+
Sbjct: 191 AFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVM 250
Query: 452 GNRFTMIWRRSFFDSNPYLERLDLSDN 478
+ R+ FD L L+L+ N
Sbjct: 251 NSH-----ERNAFDGLASLVELNLAHN 272
Score = 56.0 bits (129), Expect = 5e-07
Identities = 56/204 (27%), Positives = 86/204 (42%), Gaps = 13/204 (6%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPED 346
L N +R +E AF L L+L +N + + F L L+ L L N I IP
Sbjct: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165
Query: 347 SLLEMPSLTQLKLSR----NYLSRVGHLRSMSVTILDMSSCELNTIGKDSLEGLQSIVEL 402
+ +PSL +L L Y+S ++ L++ C + + +L L + EL
Sbjct: 166 AFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDM--PNLTPLVGLEEL 223
Query: 403 DLSQNLLSYI-PDSISS-NTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWR 460
++S N I P S ++LK L + ++S F L L L++ N + +
Sbjct: 224 EMSGNHFPEIRPGSFHGLSSLKKLWV----MNSHERNAFDGLASLVELNLAHNNLSSL-P 278
Query: 461 RSFFDSNPYLERLDLSDNMWRCDC 484
F YL L L N W CDC
Sbjct: 279 HDLFTPLRYLVELHLHHNPWNCDC 302
Score = 50.0 bits (114), Expect = 3e-05
Identities = 56/220 (25%), Positives = 99/220 (45%), Gaps = 7/220 (3%)
Query: 208 ISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSA-NNLFS-QSLKYID 265
I S+ R L + + + + L L L++ N ++ A N L S +L+ D
Sbjct: 73 IPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFD 132
Query: 266 ISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSN-NNIASLRYDTF 324
I + LR+ L +N + + S AF L LDL + + F
Sbjct: 133 NWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAF 192
Query: 325 RGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCE 384
GL LK+L+L I +P +L + L +L++S N+ + ++ L
Sbjct: 193 EGLFNLKYLNLGMCNIKDMP--NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLK-KLWV 249
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYL 424
+N+ +++ +GL S+VEL+L+ N LS +P + + L+YL
Sbjct: 250 MNSHERNAFDGLASLVELNLAHNNLSSLPHDLFT-PLRYL 288
Score = 45.2 bits (102), Expect = 9e-04
Identities = 57/197 (28%), Positives = 86/197 (43%), Gaps = 25/197 (12%)
Query: 166 LETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQN---LISSSLRSLFVSNCEL 222
LE L L I I + +GL ++ L+L N L I + S LR L++ N +
Sbjct: 101 LEVLQLGRNSIRQIEVGA-FNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
Query: 223 TSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-PNL----- 276
S+ +PSL L + +LE S +LKY+++ CNI PNL
Sbjct: 160 ESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVG 219
Query: 277 --------KGFPSLRKAILNH-NMVRYL------ESNAFANNTELEYLDLSNNNIASLRY 321
FP +R + + ++ L E NAF L L+L++NN++SL +
Sbjct: 220 LEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSHERNAFDGLASLVELNLAHNNLSSLPH 279
Query: 322 DTFRGLKMLKHLDLSWN 338
D F L+ L L L N
Sbjct: 280 DLFTPLRYLVELHLHHN 296
>BC044233-1|AAH44233.1| 692|Homo sapiens leucine rich repeat
containing 33 protein.
Length = 692
Score = 65.3 bits (152), Expect = 8e-10
Identities = 109/414 (26%), Positives = 174/414 (42%), Gaps = 28/414 (6%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSNQL 97
C L DC + L +P+ L L + N T + SL L +L + S L
Sbjct: 34 CKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL 93
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATH-LKILDLSFNKF-QTMGNL 155
+ + A L L L N N L A L+ LDLS N + M L
Sbjct: 94 ERISRGAFQEQGHLRSLVLGDNCLSE--NYEETAAALHALPGLRRLDLSGNALTEDMAAL 151
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
Q L SL ++ L I + S GL +R L L N + I+ L L
Sbjct: 152 MLQNL---SSLRSVSLAGNTIMRLDD-SVFEGLERLRELDLQRNYIFEIEGGAFDGLAEL 207
Query: 216 FVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-P 274
N +L L L L +S N LE + + L+ +D+S+ +L P
Sbjct: 208 RHLNLAFNNLPCIVDFGLTRLRVLNVSYNV-LEWFLATGGEAAFELETLDLSHNQLLFFP 266
Query: 275 NLKGFPSLRKAILNHNMV---RYLESNAFANNTELEYLDLSNN--NIASLR-YDTFRG-- 326
L + LR +L N + R L + + ++L + N NI ++ ++ F
Sbjct: 267 LLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSD 326
Query: 327 LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM----SVTILDMSS 382
L L+ LD+S N+ +P+ L +MPSL+ L L +N L + H+R ++T LD+S
Sbjct: 327 LADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTL-HIREHEPPGALTELDLSH 385
Query: 383 CELNT--IGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRIS 432
+L+ + L S+ +LS N L +P + +N + L++++N+IS
Sbjct: 386 NQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQIS 439
Score = 46.4 bits (105), Expect = 4e-04
Identities = 43/163 (26%), Positives = 67/163 (41%), Gaps = 1/163 (0%)
Query: 276 LKGFPSLRKAILNHN-MVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLD 334
L P LR+ L+ N + + + N + L + L+ N I L F GL+ L+ LD
Sbjct: 128 LHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELD 187
Query: 335 LSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLE 394
L N I I + + L L L+ N L + + +L++S L E
Sbjct: 188 LQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGE 247
Query: 395 GLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNL 437
+ LDLS N L + P + L+ L L N + +L
Sbjct: 248 AAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDL 290
Score = 44.4 bits (100), Expect = 0.002
Identities = 112/458 (24%), Positives = 177/458 (38%), Gaps = 51/458 (11%)
Query: 46 IDCSRRGLTDIPNGLGLQ----VTKLNISNNEFTKFPESLSR-LHNLVNLDISSNQLKGL 100
+D S LT+ L LQ + ++++ N + +S+ L L LD+ N + +
Sbjct: 137 LDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEI 196
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
A L L LNL+ N NL P V T L++L++S+N + +
Sbjct: 197 EGGAFDGLAELRHLNLAFN------NL-PCIVDFGLTRLRVLNVSYNVLEWFLATGGEAA 249
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNC 220
LETL L H N + L +R L L N + ++L ++S V+
Sbjct: 250 F---ELETLDLSH---NQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQF 303
Query: 221 ELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS-----LKYIDISYCNILQPN 275
L N + + S+ L + N F K +S+ N+ Q
Sbjct: 304 LLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNC 363
Query: 276 LKGFP--------SLRKAILNHNMVR--YLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
L +L + L+HN + +L + L +LS+N + + F
Sbjct: 364 LMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFA 423
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCEL 385
+ + LD+S N+I++ P + + RN S LRS+S + C L
Sbjct: 424 NARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMAS----LRSLS-----LEGCGL 474
Query: 386 NTIGKDSLEGLQSIVELDLSQN--LL--SYIPDSISSNTLKYLNL-NYNRISSINNLTFF 440
+ +G S+ LDLS N +L S P + L+ L+L N SS L F
Sbjct: 475 GALPDCPFQG-TSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFS 533
Query: 441 MLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L L + GN T R F + LE LDL N
Sbjct: 534 GFGNLRDLDLSGNCLTTFPR---FGGSLALETLDLRRN 568
>BC003193-1|AAH03193.1| 524|Homo sapiens leucine rich repeat
containing 1 protein.
Length = 524
Score = 65.3 bits (152), Expect = 8e-10
Identities = 72/231 (31%), Positives = 113/231 (48%), Gaps = 18/231 (7%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI 271
LR L +S+ E+ L F+ L L +S N E+ S + F ++L+ D S N
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFM-QLVELDVSRNEIPEIPESIS--FCKALQVADFSG-NP 116
Query: 272 LQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
L + FP L+ +N ++ L N N L L+L N + L D+ L+
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPEN-IGNLYNLASLELRENLLTYLP-DSLTQLR 174
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR----VGHLRSMSVTILDMSSCE 384
L+ LDL NEI +PE S+ + L L L N LS +G+L+++ LD+S
Sbjct: 175 RLEELDLGNNEIYNLPE-SIGALLHLKDLWLDGNQLSELPQEIGNLKNL--LCLDVSENR 231
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSI 434
L + ++ + GL S+ +L +SQNLL IPD I L L ++ NR++ +
Sbjct: 232 LERLPEE-ISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQL 281
Score = 62.1 bits (144), Expect = 7e-09
Identities = 101/418 (24%), Positives = 181/418 (43%), Gaps = 40/418 (9%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGL---GLQVTKLNISNNEFTKFPESLSRLHNLVNLDI 92
L RCN ID L +P + + +L + N+ + PE +L L L +
Sbjct: 7 LWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGL 66
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM 152
S N+++ LP + N L L++SRN P + L++ D S N +
Sbjct: 67 SDNEIQRLPPE-IANFMQLVELDVSRNEIPEI----PESISF-CKALQVADFSGNPLTRL 120
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
+ EL +L L ++ + S+ + L N+ L+L N L + + ++ L
Sbjct: 121 PE-SFPEL---QNLTCLSVNDISLQSLPEN--IGNLYNLASLELRENLLTYLPDSLTQ-L 173
Query: 213 RSLFVSNCELTSLNHNELMFLP----SLTHLK---MSNNYRLELASSANNLFSQSLKYID 265
R L E L +NE+ LP +L HLK + N EL NL ++L +D
Sbjct: 174 RRL-----EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL--KNLLCLD 226
Query: 266 ISYCNI--LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+S + L + G SL +++ N++ + + +L L + N + L +
Sbjct: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLP-EA 284
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMS 381
+ L L L+ N++ +P+ S+ ++ L+ L RN L + S+T+ +
Sbjct: 285 VGECESLTELVLTENQLLTLPK-SIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVR 343
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTF 439
L I + + + V LD++ N L ++P S+++ LK L L+ N+ + LTF
Sbjct: 344 DNRLTRIPAEVSQATELHV-LDVAGNRLLHLPLSLTALKLKALWLSDNQSQPL--LTF 398
>AY358322-1|AAQ88688.1| 692|Homo sapiens ELLP3030 protein.
Length = 692
Score = 65.3 bits (152), Expect = 8e-10
Identities = 109/414 (26%), Positives = 174/414 (42%), Gaps = 28/414 (6%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEF-TKFPESLSRLHNLVNLDISSNQL 97
C L DC + L +P+ L L + N T + SL L +L + S L
Sbjct: 34 CKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL 93
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATH-LKILDLSFNKF-QTMGNL 155
+ + A L L L N N L A L+ LDLS N + M L
Sbjct: 94 ERISRGAFQEQGHLRSLVLGDNCLSE--NYEETAAALHALPGLRRLDLSGNALTEDMAAL 151
Query: 156 ANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSL 215
Q L SL ++ L I + S GL +R L L N + I+ L L
Sbjct: 152 MLQNL---SSLRSVSLAGNTIMRLDD-SVFEGLERLRELDLQRNYIFEIEGGAFDGLAEL 207
Query: 216 FVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQ-P 274
N +L L L L +S N LE + + L+ +D+S+ +L P
Sbjct: 208 RHLNLAFNNLPCIVDFGLTRLRVLNVSYNV-LEWFLATGGEAAFELETLDLSHNQLLFFP 266
Query: 275 NLKGFPSLRKAILNHNMV---RYLESNAFANNTELEYLDLSNN--NIASLR-YDTFRG-- 326
L + LR +L N + R L + + ++L + N NI ++ ++ F
Sbjct: 267 LLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSD 326
Query: 327 LKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM----SVTILDMSS 382
L L+ LD+S N+ +P+ L +MPSL+ L L +N L + H+R ++T LD+S
Sbjct: 327 LADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTL-HIREHEPPGALTELDLSH 385
Query: 383 CELNT--IGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRIS 432
+L+ + L S+ +LS N L +P + +N + L++++N+IS
Sbjct: 386 NQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQIS 439
Score = 46.4 bits (105), Expect = 4e-04
Identities = 43/163 (26%), Positives = 67/163 (41%), Gaps = 1/163 (0%)
Query: 276 LKGFPSLRKAILNHN-MVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLD 334
L P LR+ L+ N + + + N + L + L+ N I L F GL+ L+ LD
Sbjct: 128 LHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELD 187
Query: 335 LSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNTIGKDSLE 394
L N I I + + L L L+ N L + + +L++S L E
Sbjct: 188 LQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGE 247
Query: 395 GLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNL 437
+ LDLS N L + P + L+ L L N + +L
Sbjct: 248 AAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDL 290
Score = 44.4 bits (100), Expect = 0.002
Identities = 112/458 (24%), Positives = 177/458 (38%), Gaps = 51/458 (11%)
Query: 46 IDCSRRGLTDIPNGLGLQ----VTKLNISNNEFTKFPESLSR-LHNLVNLDISSNQLKGL 100
+D S LT+ L LQ + ++++ N + +S+ L L LD+ N + +
Sbjct: 137 LDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEI 196
Query: 101 PDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQEL 160
A L L LNL+ N NL P V T L++L++S+N + +
Sbjct: 197 EGGAFDGLAELRHLNLAFN------NL-PCIVDFGLTRLRVLNVSYNVLEWFLATGGEAA 249
Query: 161 LIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNC 220
LETL L H N + L +R L L N + ++L ++S V+
Sbjct: 250 F---ELETLDLSH---NQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQF 303
Query: 221 ELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQS-----LKYIDISYCNILQPN 275
L N + + S+ L + N F K +S+ N+ Q
Sbjct: 304 LLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNC 363
Query: 276 LKGFP--------SLRKAILNHNMVR--YLESNAFANNTELEYLDLSNNNIASLRYDTFR 325
L +L + L+HN + +L + L +LS+N + + F
Sbjct: 364 LMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFA 423
Query: 326 GLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCEL 385
+ + LD+S N+I++ P + + RN S LRS+S + C L
Sbjct: 424 NARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMAS----LRSLS-----LEGCGL 474
Query: 386 NTIGKDSLEGLQSIVELDLSQN--LL--SYIPDSISSNTLKYLNL-NYNRISSINNLTFF 440
+ +G S+ LDLS N +L S P + L+ L+L N SS L F
Sbjct: 475 GALPDCPFQG-TSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFS 533
Query: 441 MLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDN 478
L L + GN T R F + LE LDL N
Sbjct: 534 GFGNLRDLDLSGNCLTTFPR---FGGSLALETLDLRRN 568
>AL513211-1|CAI17358.1| 524|Homo sapiens leucine rich repeat
containing 1 protein.
Length = 524
Score = 65.3 bits (152), Expect = 8e-10
Identities = 72/231 (31%), Positives = 113/231 (48%), Gaps = 18/231 (7%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI 271
LR L +S+ E+ L F+ L L +S N E+ S + F ++L+ D S N
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFM-QLVELDVSRNEIPEIPESIS--FCKALQVADFSG-NP 116
Query: 272 LQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
L + FP L+ +N ++ L N N L L+L N + L D+ L+
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPEN-IGNLYNLASLELRENLLTYLP-DSLTQLR 174
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR----VGHLRSMSVTILDMSSCE 384
L+ LDL NEI +PE S+ + L L L N LS +G+L+++ LD+S
Sbjct: 175 RLEELDLGNNEIYNLPE-SIGALLHLKDLWLDGNQLSELPQEIGNLKNL--LCLDVSENR 231
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSI 434
L + ++ + GL S+ +L +SQNLL IPD I L L ++ NR++ +
Sbjct: 232 LERLPEE-ISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQL 281
Score = 62.1 bits (144), Expect = 7e-09
Identities = 101/418 (24%), Positives = 181/418 (43%), Gaps = 40/418 (9%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGL---GLQVTKLNISNNEFTKFPESLSRLHNLVNLDI 92
L RCN ID L +P + + +L + N+ + PE +L L L +
Sbjct: 7 LWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGL 66
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM 152
S N+++ LP + N L L++SRN P + L++ D S N +
Sbjct: 67 SDNEIQRLPPE-IANFMQLVELDVSRNEIPEI----PESISF-CKALQVADFSGNPLTRL 120
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
+ EL +L L ++ + S+ + L N+ L+L N L + + ++ L
Sbjct: 121 PE-SFPEL---QNLTCLSVNDISLQSLPEN--IGNLYNLASLELRENLLTYLPDSLTQ-L 173
Query: 213 RSLFVSNCELTSLNHNELMFLP----SLTHLK---MSNNYRLELASSANNLFSQSLKYID 265
R L E L +NE+ LP +L HLK + N EL NL ++L +D
Sbjct: 174 RRL-----EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL--KNLLCLD 226
Query: 266 ISYCNI--LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+S + L + G SL +++ N++ + + +L L + N + L +
Sbjct: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLP-EA 284
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMS 381
+ L L L+ N++ +P+ S+ ++ L+ L RN L + S+T+ +
Sbjct: 285 VGECESLTELVLTENQLLTLPK-SIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVR 343
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTF 439
L I + + + V LD++ N L ++P S+++ LK L L+ N+ + LTF
Sbjct: 344 DNRLTRIPAEVSQATELHV-LDVAGNRLLHLPLSLTALKLKALWLSDNQSQPL--LTF 398
>AL033384-1|CAI21666.1| 524|Homo sapiens leucine rich repeat
containing 1 protein.
Length = 524
Score = 65.3 bits (152), Expect = 8e-10
Identities = 72/231 (31%), Positives = 113/231 (48%), Gaps = 18/231 (7%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI 271
LR L +S+ E+ L F+ L L +S N E+ S + F ++L+ D S N
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFM-QLVELDVSRNEIPEIPESIS--FCKALQVADFSG-NP 116
Query: 272 LQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
L + FP L+ +N ++ L N N L L+L N + L D+ L+
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPEN-IGNLYNLASLELRENLLTYLP-DSLTQLR 174
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR----VGHLRSMSVTILDMSSCE 384
L+ LDL NEI +PE S+ + L L L N LS +G+L+++ LD+S
Sbjct: 175 RLEELDLGNNEIYNLPE-SIGALLHLKDLWLDGNQLSELPQEIGNLKNL--LCLDVSENR 231
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSI 434
L + ++ + GL S+ +L +SQNLL IPD I L L ++ NR++ +
Sbjct: 232 LERLPEE-ISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQL 281
Score = 62.1 bits (144), Expect = 7e-09
Identities = 101/418 (24%), Positives = 181/418 (43%), Gaps = 40/418 (9%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGL---GLQVTKLNISNNEFTKFPESLSRLHNLVNLDI 92
L RCN ID L +P + + +L + N+ + PE +L L L +
Sbjct: 7 LWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGL 66
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM 152
S N+++ LP + N L L++SRN P + L++ D S N +
Sbjct: 67 SDNEIQRLPPE-IANFMQLVELDVSRNEIPEI----PESISF-CKALQVADFSGNPLTRL 120
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
+ EL +L L ++ + S+ + L N+ L+L N L + + ++ L
Sbjct: 121 PE-SFPEL---QNLTCLSVNDISLQSLPEN--IGNLYNLASLELRENLLTYLPDSLTQ-L 173
Query: 213 RSLFVSNCELTSLNHNELMFLP----SLTHLK---MSNNYRLELASSANNLFSQSLKYID 265
R L E L +NE+ LP +L HLK + N EL NL ++L +D
Sbjct: 174 RRL-----EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL--KNLLCLD 226
Query: 266 ISYCNI--LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+S + L + G SL +++ N++ + + +L L + N + L +
Sbjct: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLP-EA 284
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMS 381
+ L L L+ N++ +P+ S+ ++ L+ L RN L + S+T+ +
Sbjct: 285 VGECESLTELVLTENQLLTLPK-SIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVR 343
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTF 439
L I + + + V LD++ N L ++P S+++ LK L L+ N+ + LTF
Sbjct: 344 DNRLTRIPAEVSQATELHV-LDVAGNRLLHLPLSLTALKLKALWLSDNQSQPL--LTF 398
>AF359380-1|AAK72246.1| 524|Homo sapiens LANO adaptor protein
protein.
Length = 524
Score = 65.3 bits (152), Expect = 8e-10
Identities = 72/231 (31%), Positives = 113/231 (48%), Gaps = 18/231 (7%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI 271
LR L +S+ E+ L F+ L L +S N E+ S + F ++L+ D S N
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFM-QLVELDVSRNEIPEIPESIS--FCKALQVADFSG-NP 116
Query: 272 LQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
L + FP L+ +N ++ L N N L L+L N + L D+ L+
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPEN-IGNLYNLASLELRENLLTYLP-DSLTQLR 174
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR----VGHLRSMSVTILDMSSCE 384
L+ LDL NEI +PE S+ + L L L N LS +G+L+++ LD+S
Sbjct: 175 RLEELDLGNNEIYNLPE-SIGALLHLKDLWLDGNQLSELPQEIGNLKNL--LCLDVSENR 231
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSI 434
L + ++ + GL S+ +L +SQNLL IPD I L L ++ NR++ +
Sbjct: 232 LERLPEE-ISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQL 281
Score = 62.1 bits (144), Expect = 7e-09
Identities = 101/418 (24%), Positives = 181/418 (43%), Gaps = 40/418 (9%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGL---GLQVTKLNISNNEFTKFPESLSRLHNLVNLDI 92
L RCN ID L +P + + +L + N+ + PE +L L L +
Sbjct: 7 LWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGL 66
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM 152
S N+++ LP + N L L++SRN P + L++ D S N +
Sbjct: 67 SDNEIQRLPPE-IANFMQLVELDVSRNEIPEI----PESISF-CKALQVADFSGNPLTRL 120
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
+ EL +L L ++ + S+ + L N+ L+L N L + + ++ L
Sbjct: 121 PE-SFPEL---QNLTCLSVNDISLQSLPEN--IGNLYNLASLELRENLLTYLPDSLTQ-L 173
Query: 213 RSLFVSNCELTSLNHNELMFLP----SLTHLK---MSNNYRLELASSANNLFSQSLKYID 265
R L E L +NE+ LP +L HLK + N EL NL ++L +D
Sbjct: 174 RRL-----EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL--KNLLCLD 226
Query: 266 ISYCNI--LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+S + L + G SL +++ N++ + + +L L + N + L +
Sbjct: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLP-EA 284
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMS 381
+ L L L+ N++ +P+ S+ ++ L+ L RN L + S+T+ +
Sbjct: 285 VGECESLTELVLTENQLLTLPK-SIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVR 343
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTF 439
L I + + + V LD++ N L ++P S+++ LK L L+ N+ + LTF
Sbjct: 344 DNRLTRIPAEVSQATELHV-LDVAGNRLLHLPLSLTALKLKALWLSDNQSQPL--LTF 398
>AF332199-1|AAK69623.1| 524|Homo sapiens leucine-rich repeats
protein protein.
Length = 524
Score = 65.3 bits (152), Expect = 8e-10
Identities = 72/231 (31%), Positives = 113/231 (48%), Gaps = 18/231 (7%)
Query: 212 LRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNI 271
LR L +S+ E+ L F+ L L +S N E+ S + F ++L+ D S N
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFM-QLVELDVSRNEIPEIPESIS--FCKALQVADFSG-NP 116
Query: 272 LQPNLKGFPSLRKAI---LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLK 328
L + FP L+ +N ++ L N N L L+L N + L D+ L+
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPEN-IGNLYNLASLELRENLLTYLP-DSLTQLR 174
Query: 329 MLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR----VGHLRSMSVTILDMSSCE 384
L+ LDL NEI +PE S+ + L L L N LS +G+L+++ LD+S
Sbjct: 175 RLEELDLGNNEIYNLPE-SIGALLHLKDLWLDGNQLSELPQEIGNLKNL--LCLDVSENR 231
Query: 385 LNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISS-NTLKYLNLNYNRISSI 434
L + ++ + GL S+ +L +SQNLL IPD I L L ++ NR++ +
Sbjct: 232 LERLPEE-ISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQL 281
Score = 62.1 bits (144), Expect = 7e-09
Identities = 101/418 (24%), Positives = 181/418 (43%), Gaps = 40/418 (9%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGL---GLQVTKLNISNNEFTKFPESLSRLHNLVNLDI 92
L RCN ID L +P + + +L + N+ + PE +L L L +
Sbjct: 7 LWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGL 66
Query: 93 SSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTM 152
S N+++ LP + N L L++SRN P + L++ D S N +
Sbjct: 67 SDNEIQRLPPE-IANFMQLVELDVSRNEIPEI----PESISF-CKALQVADFSGNPLTRL 120
Query: 153 GNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSL 212
+ EL +L L ++ + S+ + L N+ L+L N L + + ++ L
Sbjct: 121 PE-SFPEL---QNLTCLSVNDISLQSLPEN--IGNLYNLASLELRENLLTYLPDSLTQ-L 173
Query: 213 RSLFVSNCELTSLNHNELMFLP----SLTHLK---MSNNYRLELASSANNLFSQSLKYID 265
R L E L +NE+ LP +L HLK + N EL NL ++L +D
Sbjct: 174 RRL-----EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL--KNLLCLD 226
Query: 266 ISYCNI--LQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDT 323
+S + L + G SL +++ N++ + + +L L + N + L +
Sbjct: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLP-EA 284
Query: 324 FRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRS--MSVTILDMS 381
+ L L L+ N++ +P+ S+ ++ L+ L RN L + S+T+ +
Sbjct: 285 VGECESLTELVLTENQLLTLPK-SIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVR 343
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSNTLKYLNLNYNRISSINNLTF 439
L I + + + V LD++ N L ++P S+++ LK L L+ N+ + LTF
Sbjct: 344 DNRLTRIPAEVSQATELHV-LDVAGNRLLHLPLSLTALKLKALWLSDNQSQPL--LTF 398
>BC101761-1|AAI01762.1| 545|Homo sapiens leucine-rich repeat LGI
family, member 2 protein.
Length = 545
Score = 64.9 bits (151), Expect = 1e-09
Identities = 35/103 (33%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ ++ I PSL+ +LN N + +AFA LEYL + N I ++
Sbjct: 65 SLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETI 124
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
+ FRGL+ L HL L+ N I +P D ++ SL +L L N
Sbjct: 125 SRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGN 167
Score = 44.0 bits (99), Expect = 0.002
Identities = 31/91 (34%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 396 LQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
L S+ L L+ N + I D + L+YL + N+I +I+ F L LT LS+ N
Sbjct: 84 LPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANN 143
Query: 454 RFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
+ R F D + +E LDL N + CDC
Sbjct: 144 HIKALPRDVFSDLDSLIE-LDLRGNKFECDC 173
Score = 39.9 bits (89), Expect = 0.032
Identities = 20/70 (28%), Positives = 39/70 (55%)
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
++ F++ L+ L L++N+ +R D F GL L++L + N+I I ++ + L
Sbjct: 76 IKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDL 135
Query: 355 TQLKLSRNYL 364
T L L+ N++
Sbjct: 136 THLSLANNHI 145
Score = 38.3 bits (85), Expect = 0.099
Identities = 23/73 (31%), Positives = 33/73 (45%)
Query: 267 SYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRG 326
S+ I G L + N + + NAF +L +L L+NN+I +L D F
Sbjct: 96 SFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSD 155
Query: 327 LKMLKHLDLSWNE 339
L L LDL N+
Sbjct: 156 LDSLIELDLRGNK 168
>BC101759-1|AAI01760.1| 545|Homo sapiens leucine-rich repeat LGI
family, member 2 protein.
Length = 545
Score = 64.9 bits (151), Expect = 1e-09
Identities = 35/103 (33%), Positives = 53/103 (51%)
Query: 260 SLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASL 319
SL ++ ++ I PSL+ +LN N + +AFA LEYL + N I ++
Sbjct: 65 SLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETI 124
Query: 320 RYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRN 362
+ FRGL+ L HL L+ N I +P D ++ SL +L L N
Sbjct: 125 SRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGN 167
Score = 44.0 bits (99), Expect = 0.002
Identities = 31/91 (34%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 396 LQSIVELDLSQNLLSYIPDSISSNT--LKYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
L S+ L L+ N + I D + L+YL + N+I +I+ F L LT LS+ N
Sbjct: 84 LPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANN 143
Query: 454 RFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
+ R F D + +E LDL N + CDC
Sbjct: 144 HIKALPRDVFSDLDSLIE-LDLRGNKFECDC 173
Score = 39.9 bits (89), Expect = 0.032
Identities = 20/70 (28%), Positives = 39/70 (55%)
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
++ F++ L+ L L++N+ +R D F GL L++L + N+I I ++ + L
Sbjct: 76 IKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDL 135
Query: 355 TQLKLSRNYL 364
T L L+ N++
Sbjct: 136 THLSLANNHI 145
Score = 38.3 bits (85), Expect = 0.099
Identities = 23/73 (31%), Positives = 33/73 (45%)
Query: 267 SYCNILQPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRG 326
S+ I G L + N + + NAF +L +L L+NN+I +L D F
Sbjct: 96 SFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSD 155
Query: 327 LKMLKHLDLSWNE 339
L L LDL N+
Sbjct: 156 LDSLIELDLRGNK 168
>AY029183-1|AAK31796.1| 798|Homo sapiens SLIT1 isoform B protein.
Length = 798
Score = 64.9 bits (151), Expect = 1e-09
Identities = 43/152 (28%), Positives = 77/152 (50%), Gaps = 5/152 (3%)
Query: 307 EYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR 366
E L+L+ NNI + + F GLK L+ L L N+I + + +M L +L+L+RN L
Sbjct: 47 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 106
Query: 367 VGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTL 421
+ L + +++ LD+S + I + + G + L L +N +S I + + L
Sbjct: 107 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 166
Query: 422 KYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
+ L LN N I++I +F + +L + + N
Sbjct: 167 EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSN 198
Score = 55.6 bits (128), Expect = 6e-07
Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 3/128 (2%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
+L + L+ N ++ + AF T+L+ L L N I+ + FR L+ L+ L L+ N I
Sbjct: 117 ALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNI 176
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT--IGKDSLEGLQS 398
IP S MP L +L N+L HL +S + + L T G SL GL +
Sbjct: 177 TTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGL-N 235
Query: 399 IVELDLSQ 406
+ E+ S+
Sbjct: 236 VAEVQKSE 243
Score = 52.8 bits (121), Expect = 4e-06
Identities = 35/116 (30%), Positives = 62/116 (53%), Gaps = 3/116 (2%)
Query: 379 DMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSINN 436
D+S+ ++ I D+ +GL+S+ L L N ++ +P + TL+ L LN N+I+ I
Sbjct: 332 DLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRP 391
Query: 437 LTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDF 492
F L L+ LS+ N+ + + F S ++ L L+ N + CDC+ + + DF
Sbjct: 392 DAFQDLQNLSLLSLYDNKIQSL-AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADF 446
Score = 52.0 bits (119), Expect = 8e-06
Identities = 30/86 (34%), Positives = 43/86 (50%)
Query: 282 LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIA 341
L + LN N + L F NN L LDLS N I ++ FRG LK+L L N+I+
Sbjct: 94 LERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS 153
Query: 342 VIPEDSLLEMPSLTQLKLSRNYLSRV 367
I E + + L L L+ N ++ +
Sbjct: 154 CIEEGAFRALRGLEVLTLNNNNITTI 179
Score = 51.2 bits (117), Expect = 1e-05
Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 3/135 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G LR L N + +E AF + ELE L L+ N + L F+ + L LDLS
Sbjct: 66 GLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSE 125
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLE 394
N I IP + L L+L +N +S + G R++ + +L +++ + TI S
Sbjct: 126 NAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN 185
Query: 395 GLQSIVELDLSQNLL 409
+ + L N L
Sbjct: 186 HMPKLRTFRLHSNHL 200
Score = 50.8 bits (116), Expect = 2e-05
Identities = 69/346 (19%), Positives = 143/346 (41%), Gaps = 19/346 (5%)
Query: 68 NISNNEFTKF-PESLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLN 126
++SNN+ + P++ L +L +L + N++ LP L L++L L+ N +
Sbjct: 332 DLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC--- 388
Query: 127 LNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLS 186
+ P D +L +L L NK Q+ LA +++TL L L+
Sbjct: 389 IRP-DAFQDLQNLSLLSLYDNKIQS---LAKGTFTSLRAIQTLHLAQNPFICDCNLKWLA 444
Query: 187 GLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHNELMFLPSLTHLKMSNNYR 246
+ ++ + + L + + + ++ E F+P ++++
Sbjct: 445 DFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSA---KEQYFIPGTEDYQLNSECN 501
Query: 247 LELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRYLESNA-FANNTE 305
++ ++ ++ S + + + S + LN+N + LE+ F T
Sbjct: 502 SDVVCPHKCRCEANV--VECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTH 559
Query: 306 LEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLS 365
L+ ++LSNN ++ + F G + L L+ N++ I + L L L N +S
Sbjct: 560 LKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRIS 619
Query: 366 RVGHLRSM----SVTILDMSSCELNTIGKDSLEGLQSIVELDLSQN 407
+ H S +V +L + ++ T+ + + LQS+ L+L N
Sbjct: 620 CI-HNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLAN 664
Score = 50.4 bits (115), Expect = 2e-05
Identities = 40/138 (28%), Positives = 71/138 (51%), Gaps = 7/138 (5%)
Query: 353 SLTQLKLSRNYLS---RVGHLRSMS-VTILDMSSCELNTIGKDSLEGLQSIVELDLSQNL 408
S +L+L+ N +S G + ++ + +++S+ +++ I + EG S+ EL L+ N
Sbjct: 534 STAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQ 593
Query: 409 LSYIPDSI--SSNTLKYLNLNYNRISSINNLTFFMLNRLTSLSVVGNRFTMIWRRSFFDS 466
L I + + L+ L L NRIS I+N +F L + LS+ N+ T + FD+
Sbjct: 594 LESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTV-SPGAFDT 652
Query: 467 NPYLERLDLSDNMWRCDC 484
L L+L N + C+C
Sbjct: 653 LQSLSTLNLLANPFNCNC 670
Score = 49.6 bits (113), Expect = 4e-05
Identities = 48/170 (28%), Positives = 73/170 (42%), Gaps = 11/170 (6%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
LC C T +DC GL IP + +L ++ N T+ ++ + L L L +
Sbjct: 20 LCTCT--GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLME 77
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
NQ+ + A ++ LE L L+RN L++ P + L LDLS N Q +
Sbjct: 78 NQIGAVERGAFDDMKELERLRLNRNQ----LHMLPELLFQNNQALSRLDLSENAIQAIPR 133
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI 204
A + L+ L LD +I+ I L + VL LN N + I
Sbjct: 134 KAFRG---ATDLKNLQLDKNQISCIE-EGAFRALRGLEVLTLNNNNITTI 179
Score = 45.6 bits (103), Expect = 7e-04
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 20/174 (11%)
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLN 226
E L L+ I IH ++ +GL +RVL+L N + ++ ++ L E LN
Sbjct: 47 ERLELNGNNITRIH-KNDFAGLKQLRVLQLMENQIGAVERGAFDDMKEL-----ERLRLN 100
Query: 227 HNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI 286
N+L LP L RL+L+ +A + +G L+
Sbjct: 101 RNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKA--------------FRGATDLKNLQ 146
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
L+ N + +E AF LE L L+NNNI ++ +F + L+ L N +
Sbjct: 147 LDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 200
Score = 42.7 bits (96), Expect = 0.005
Identities = 21/88 (23%), Positives = 45/88 (51%), Gaps = 2/88 (2%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES--LSRLHNLVNLDISSN 95
+C + ++CS LT IP + +L ++NNE + + +L +L +++S+N
Sbjct: 509 KCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNN 568
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDS 123
++ + D A ++ L+L+ N +S
Sbjct: 569 KVSEIEDGAFEGAASVSELHLTANQLES 596
Score = 40.7 bits (91), Expect = 0.019
Identities = 24/65 (36%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQ 96
C C LD T + CS + L +P G+ VT+L + N+FT P LS L + +S N
Sbjct: 731 CAC-LD-TVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVILSYNA 788
Query: 97 LKGLP 101
L+ +P
Sbjct: 789 LQCIP 793
Score = 38.7 bits (86), Expect = 0.075
Identities = 42/173 (24%), Positives = 78/173 (45%), Gaps = 11/173 (6%)
Query: 57 PNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYN-LTALEVLN 115
P+ + + S+ + TK PE + + + L +++N++ L ++ LT L+ +N
Sbjct: 507 PHKCRCEANVVECSSLKLTKIPERIPQ--STAELRLNNNEISILEATGMFKKLTHLKKIN 564
Query: 116 LSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
LS N + A + L L+ N+ +++ + + L L TL+L +
Sbjct: 565 LSNNKVSEI----EDGAFEGAASVSELHLTANQLESIRSGMFRGL---DGLRTLMLRNNR 617
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHN 228
I+ IH S +GL N+R+L L N + + +L+SL N N N
Sbjct: 618 ISCIHNDS-FTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCN 669
Score = 35.1 bits (77), Expect = 0.92
Identities = 48/180 (26%), Positives = 73/180 (40%), Gaps = 19/180 (10%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFP-------ESLSRLHNLVNL- 90
C +DC +GLT IP L +T++ + N P L R+ L
Sbjct: 269 CTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIRPLSFCS 328
Query: 91 ---DISSNQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFN 147
D+S+NQ+ + +A L +L L L N P V L++L L+ N
Sbjct: 329 PCRDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDL----PRGVFGGLYTLQLLLLNAN 384
Query: 148 KFQTMGNLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNL 207
K + A Q+L +L L L +I S+ + + L I+ L L NP + NL
Sbjct: 385 KINCIRPDAFQDL---QNLSLLSLYDNKIQSL-AKGTFTSLRAIQTLHLAQNPFICDCNL 440
>AL512424-5|CAI14258.1| 1534|Homo sapiens slit homolog 1
(Drosophila) protein.
Length = 1534
Score = 64.9 bits (151), Expect = 1e-09
Identities = 43/152 (28%), Positives = 77/152 (50%), Gaps = 5/152 (3%)
Query: 307 EYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR 366
E L+L+ NNI + + F GLK L+ L L N+I + + +M L +L+L+RN L
Sbjct: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 123
Query: 367 VGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTL 421
+ L + +++ LD+S + I + + G + L L +N +S I + + L
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 183
Query: 422 KYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
+ L LN N I++I +F + +L + + N
Sbjct: 184 EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSN 215
Score = 58.0 bits (134), Expect = 1e-07
Identities = 74/320 (23%), Positives = 139/320 (43%), Gaps = 21/320 (6%)
Query: 66 KLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN----- 119
K+N+SNN+ ++ + + ++ L +++NQL+ + L L L L N
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628
Query: 120 YFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSI 179
+ DS+ L N LL +I +S F T+ +L+ LL P +C++ +
Sbjct: 629 HNDSFTGLR-NVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANP-----FNCNCQLAWL 682
Query: 180 HGRSPLSGLI--NIRVLKLNFNPLLRIQNLISSSLR---SLFVSNCELTSLNHNELMFLP 234
G ++ N R +F + +Q++ R C E L
Sbjct: 683 GGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLD 742
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRY 294
++ ++ SN + L ++ Y+D + ++ L F L+ L++N +
Sbjct: 743 TV--VRCSNKHLRALPKGIPKNVTEL--YLDGNQFTLVPGQLSTFKYLQLVDLSNNKISS 798
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
L +++F N ++L L LS N + + F+GL+ L+ L L N+I+ + E ++ SL
Sbjct: 799 LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSL 858
Query: 355 TQLKLSRNYLSRVGHLRSMS 374
+ L + N L HLR +S
Sbjct: 859 SHLAIGANPLYCDCHLRWLS 878
Score = 55.6 bits (128), Expect = 6e-07
Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 3/128 (2%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
+L + L+ N ++ + AF T+L+ L L N I+ + FR L+ L+ L L+ N I
Sbjct: 134 ALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNI 193
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT--IGKDSLEGLQS 398
IP S MP L +L N+L HL +S + + L T G SL GL +
Sbjct: 194 TTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGL-N 252
Query: 399 IVELDLSQ 406
+ E+ S+
Sbjct: 253 VAEVQKSE 260
Score = 55.6 bits (128), Expect = 6e-07
Identities = 101/405 (24%), Positives = 176/405 (43%), Gaps = 37/405 (9%)
Query: 99 GLPDNALYNLTALEVLNLSRNYFDSWLNLN-----PNDVLLPATHLKILDLSFNKFQTMG 153
G+ D LTA+ NL + L LN P P L+ +DLS N+ +
Sbjct: 291 GIVDCRGKGLTAIPA-NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIA 349
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
A Q L SL +L+L +I + R GL +++L LN N +I + + +
Sbjct: 350 PDAFQGLR---SLNSLVLYGNKITDLP-RGVFGGLYTLQLLLLNAN---KINCIRPDAFQ 402
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYI-DISYCNIL 272
L N L SL N++ L T + L LA + + +LK++ D N +
Sbjct: 403 DL--QNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF-ICDCNLKWLADFLRTNPI 459
Query: 273 QPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI---ASLRYDTFRGLKM 329
+ + S R+ L + + ++S F + + +Y + + D K
Sbjct: 460 ETSGARCASPRR--LANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKC 517
Query: 330 ---LKHLDLSWNEIAVIPEDSLLEMPSLT-QLKLSRNYLS---RVGHLRSMS-VTILDMS 381
++ S ++ IPE +P T +L+L+ N +S G + ++ + +++S
Sbjct: 518 RCEANVVECSSLKLTKIPE----RIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLS 573
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTF 439
+ +++ I + EG S+ EL L+ N L I + + L+ L L NRIS I+N +F
Sbjct: 574 NNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSF 633
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
L + LS+ N+ T + FD+ L L+L N + C+C
Sbjct: 634 TGLRNVRLLSLYDNQITTV-SPGAFDTLQSLSTLNLLANPFNCNC 677
Score = 54.0 bits (124), Expect = 2e-06
Identities = 30/83 (36%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQ 96
C C LD T + CS + L +P G+ VT+L + N+FT P LS L +D+S+N+
Sbjct: 738 CAC-LD-TVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNK 795
Query: 97 LKGLPDNALYNLTALEVLNLSRN 119
+ L +++ N++ L L LS N
Sbjct: 796 ISSLSNSSFTNMSQLTTLILSYN 818
Score = 53.6 bits (123), Expect = 2e-06
Identities = 35/117 (29%), Positives = 63/117 (53%), Gaps = 3/117 (2%)
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSIN 435
+D+S+ ++ I D+ +GL+S+ L L N ++ +P + TL+ L LN N+I+ I
Sbjct: 338 IDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIR 397
Query: 436 NLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDF 492
F L L+ LS+ N+ + + F S ++ L L+ N + CDC+ + + DF
Sbjct: 398 PDAFQDLQNLSLLSLYDNKIQSL-AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADF 453
Score = 52.0 bits (119), Expect = 8e-06
Identities = 30/86 (34%), Positives = 43/86 (50%)
Query: 282 LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIA 341
L + LN N + L F NN L LDLS N I ++ FRG LK+L L N+I+
Sbjct: 111 LERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS 170
Query: 342 VIPEDSLLEMPSLTQLKLSRNYLSRV 367
I E + + L L L+ N ++ +
Sbjct: 171 CIEEGAFRALRGLEVLTLNNNNITTI 196
Score = 51.2 bits (117), Expect = 1e-05
Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 3/135 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G LR L N + +E AF + ELE L L+ N + L F+ + L LDLS
Sbjct: 83 GLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSE 142
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLE 394
N I IP + L L+L +N +S + G R++ + +L +++ + TI S
Sbjct: 143 NAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN 202
Query: 395 GLQSIVELDLSQNLL 409
+ + L N L
Sbjct: 203 HMPKLRTFRLHSNHL 217
Score = 50.0 bits (114), Expect = 3e-05
Identities = 85/370 (22%), Positives = 158/370 (42%), Gaps = 32/370 (8%)
Query: 57 PNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYN-LTALEVLN 115
P+ + + S+ + TK PE + + + L +++N++ L ++ LT L+ +N
Sbjct: 514 PHKCRCEANVVECSSLKLTKIPERIPQ--STAELRLNNNEISILEATGMFKKLTHLKKIN 571
Query: 116 LSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
LS N + A + L L+ N+ +++ + + L L TL+L +
Sbjct: 572 LSNNKVSEI----EDGAFEGAASVSELHLTANQLESIRSGMFRGL---DGLRTLMLRNNR 624
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHN-ELMFLP 234
I+ IH S +GL N+R+L L N + + +L+SL N N N +L +L
Sbjct: 625 ISCIHNDS-FTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLG 683
Query: 235 SLTHLK--MSNNYRLELASSANNLFSQSLKYIDISYCN--------ILQPNLKGFPSLRK 284
+ ++ N R + + Q + + D C + +P +
Sbjct: 684 GWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR-CEEGQEEGGCLPRPQCPQECACLD 742
Query: 285 AIL--NHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAV 342
++ ++ +R L N TEL YLD + + + TF K L+ +DLS N+I+
Sbjct: 743 TVVRCSNKHLRALPKGIPKNVTEL-YLDGNQFTLVPGQLSTF---KYLQLVDLSNNKISS 798
Query: 343 IPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM---SVTILDMSSCELNTIGKDSLEGLQSI 399
+ S M LT L LS N L + L S+ +L + +++T+ + + S+
Sbjct: 799 LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSL 858
Query: 400 VELDLSQNLL 409
L + N L
Sbjct: 859 SHLAIGANPL 868
Score = 49.6 bits (113), Expect = 4e-05
Identities = 48/170 (28%), Positives = 73/170 (42%), Gaps = 11/170 (6%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
LC C T +DC GL IP + +L ++ N T+ ++ + L L L +
Sbjct: 37 LCTCT--GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLME 94
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
NQ+ + A ++ LE L L+RN L++ P + L LDLS N Q +
Sbjct: 95 NQIGAVERGAFDDMKELERLRLNRNQ----LHMLPELLFQNNQALSRLDLSENAIQAIPR 150
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI 204
A + L+ L LD +I+ I L + VL LN N + I
Sbjct: 151 KAFRG---ATDLKNLQLDKNQISCIE-EGAFRALRGLEVLTLNNNNITTI 196
Score = 46.0 bits (104), Expect = 5e-04
Identities = 47/170 (27%), Positives = 73/170 (42%), Gaps = 9/170 (5%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL 97
C +DC +GLT IP L +T++ + N P + S L +D+S+NQ+
Sbjct: 286 CTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQI 345
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLAN 157
+ +A L +L L L N P V L++L L+ NK + A
Sbjct: 346 AEIAPDAFQGLRSLNSLVLYGNKITDL----PRGVFGGLYTLQLLLLNANKINCIRPDAF 401
Query: 158 QELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNL 207
Q+L +L L L +I S+ + + L I+ L L NP + NL
Sbjct: 402 QDL---QNLSLLSLYDNKIQSL-AKGTFTSLRAIQTLHLAQNPFICDCNL 447
Score = 45.6 bits (103), Expect = 7e-04
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 20/174 (11%)
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLN 226
E L L+ I IH ++ +GL +RVL+L N + ++ ++ L E LN
Sbjct: 64 ERLELNGNNITRIH-KNDFAGLKQLRVLQLMENQIGAVERGAFDDMKEL-----ERLRLN 117
Query: 227 HNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI 286
N+L LP L RL+L+ +A + +G L+
Sbjct: 118 RNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKA--------------FRGATDLKNLQ 163
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
L+ N + +E AF LE L L+NNNI ++ +F + L+ L N +
Sbjct: 164 LDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Score = 42.7 bits (96), Expect = 0.005
Identities = 21/88 (23%), Positives = 45/88 (51%), Gaps = 2/88 (2%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES--LSRLHNLVNLDISSN 95
+C + ++CS LT IP + +L ++NNE + + +L +L +++S+N
Sbjct: 516 KCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNN 575
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDS 123
++ + D A ++ L+L+ N +S
Sbjct: 576 KVSEIEDGAFEGAASVSELHLTANQLES 603
>AL512424-4|CAI14259.1| 1461|Homo sapiens slit homolog 1
(Drosophila) protein.
Length = 1461
Score = 64.9 bits (151), Expect = 1e-09
Identities = 43/152 (28%), Positives = 77/152 (50%), Gaps = 5/152 (3%)
Query: 307 EYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR 366
E L+L+ NNI + + F GLK L+ L L N+I + + +M L +L+L+RN L
Sbjct: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 123
Query: 367 VGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTL 421
+ L + +++ LD+S + I + + G + L L +N +S I + + L
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 183
Query: 422 KYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
+ L LN N I++I +F + +L + + N
Sbjct: 184 EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSN 215
Score = 58.0 bits (134), Expect = 1e-07
Identities = 74/320 (23%), Positives = 139/320 (43%), Gaps = 21/320 (6%)
Query: 66 KLNISNNEFTKFPE-SLSRLHNLVNLDISSNQLKGLPDNALYNLTALEVLNLSRN----- 119
K+N+SNN+ ++ + + ++ L +++NQL+ + L L L L N
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCI 628
Query: 120 YFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCEINSI 179
+ DS+ L N LL +I +S F T+ +L+ LL P +C++ +
Sbjct: 629 HNDSFTGLR-NVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANP-----FNCNCQLAWL 682
Query: 180 HGRSPLSGLI--NIRVLKLNFNPLLRIQNLISSSLR---SLFVSNCELTSLNHNELMFLP 234
G ++ N R +F + +Q++ R C E L
Sbjct: 683 GGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLD 742
Query: 235 SLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAILNHNMVRY 294
++ ++ SN + L ++ Y+D + ++ L F L+ L++N +
Sbjct: 743 TV--VRCSNKHLRALPKGIPKNVTEL--YLDGNQFTLVPGQLSTFKYLQLVDLSNNKISS 798
Query: 295 LESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSL 354
L +++F N ++L L LS N + + F+GL+ L+ L L N+I+ + E ++ SL
Sbjct: 799 LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSL 858
Query: 355 TQLKLSRNYLSRVGHLRSMS 374
+ L + N L HLR +S
Sbjct: 859 SHLAIGANPLYCDCHLRWLS 878
Score = 55.6 bits (128), Expect = 6e-07
Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 3/128 (2%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
+L + L+ N ++ + AF T+L+ L L N I+ + FR L+ L+ L L+ N I
Sbjct: 134 ALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNI 193
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT--IGKDSLEGLQS 398
IP S MP L +L N+L HL +S + + L T G SL GL +
Sbjct: 194 TTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGL-N 252
Query: 399 IVELDLSQ 406
+ E+ S+
Sbjct: 253 VAEVQKSE 260
Score = 55.6 bits (128), Expect = 6e-07
Identities = 101/405 (24%), Positives = 176/405 (43%), Gaps = 37/405 (9%)
Query: 99 GLPDNALYNLTALEVLNLSRNYFDSWLNLN-----PNDVLLPATHLKILDLSFNKFQTMG 153
G+ D LTA+ NL + L LN P P L+ +DLS N+ +
Sbjct: 291 GIVDCRGKGLTAIPA-NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIA 349
Query: 154 NLANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLR 213
A Q L SL +L+L +I + R GL +++L LN N +I + + +
Sbjct: 350 PDAFQGLR---SLNSLVLYGNKITDLP-RGVFGGLYTLQLLLLNAN---KINCIRPDAFQ 402
Query: 214 SLFVSNCELTSLNHNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYI-DISYCNIL 272
L N L SL N++ L T + L LA + + +LK++ D N +
Sbjct: 403 DL--QNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPF-ICDCNLKWLADFLRTNPI 459
Query: 273 QPNLKGFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNI---ASLRYDTFRGLKM 329
+ + S R+ L + + ++S F + + +Y + + D K
Sbjct: 460 ETSGARCASPRR--LANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKC 517
Query: 330 ---LKHLDLSWNEIAVIPEDSLLEMPSLT-QLKLSRNYLS---RVGHLRSMS-VTILDMS 381
++ S ++ IPE +P T +L+L+ N +S G + ++ + +++S
Sbjct: 518 RCEANVVECSSLKLTKIPE----RIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLS 573
Query: 382 SCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTLKYLNLNYNRISSINNLTF 439
+ +++ I + EG S+ EL L+ N L I + + L+ L L NRIS I+N +F
Sbjct: 574 NNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSF 633
Query: 440 FMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDC 484
L + LS+ N+ T + FD+ L L+L N + C+C
Sbjct: 634 TGLRNVRLLSLYDNQITTV-SPGAFDTLQSLSTLNLLANPFNCNC 677
Score = 54.0 bits (124), Expect = 2e-06
Identities = 30/83 (36%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 37 CRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQ 96
C C LD T + CS + L +P G+ VT+L + N+FT P LS L +D+S+N+
Sbjct: 738 CAC-LD-TVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNK 795
Query: 97 LKGLPDNALYNLTALEVLNLSRN 119
+ L +++ N++ L L LS N
Sbjct: 796 ISSLSNSSFTNMSQLTTLILSYN 818
Score = 53.6 bits (123), Expect = 2e-06
Identities = 35/117 (29%), Positives = 63/117 (53%), Gaps = 3/117 (2%)
Query: 378 LDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSISSN--TLKYLNLNYNRISSIN 435
+D+S+ ++ I D+ +GL+S+ L L N ++ +P + TL+ L LN N+I+ I
Sbjct: 338 IDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIR 397
Query: 436 NLTFFMLNRLTSLSVVGNRFTMIWRRSFFDSNPYLERLDLSDNMWRCDCSDENMRDF 492
F L L+ LS+ N+ + + F S ++ L L+ N + CDC+ + + DF
Sbjct: 398 PDAFQDLQNLSLLSLYDNKIQSL-AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADF 453
Score = 52.0 bits (119), Expect = 8e-06
Identities = 30/86 (34%), Positives = 43/86 (50%)
Query: 282 LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIA 341
L + LN N + L F NN L LDLS N I ++ FRG LK+L L N+I+
Sbjct: 111 LERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS 170
Query: 342 VIPEDSLLEMPSLTQLKLSRNYLSRV 367
I E + + L L L+ N ++ +
Sbjct: 171 CIEEGAFRALRGLEVLTLNNNNITTI 196
Score = 51.2 bits (117), Expect = 1e-05
Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 3/135 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G LR L N + +E AF + ELE L L+ N + L F+ + L LDLS
Sbjct: 83 GLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSE 142
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLE 394
N I IP + L L+L +N +S + G R++ + +L +++ + TI S
Sbjct: 143 NAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN 202
Query: 395 GLQSIVELDLSQNLL 409
+ + L N L
Sbjct: 203 HMPKLRTFRLHSNHL 217
Score = 50.0 bits (114), Expect = 3e-05
Identities = 85/370 (22%), Positives = 158/370 (42%), Gaps = 32/370 (8%)
Query: 57 PNGLGLQVTKLNISNNEFTKFPESLSRLHNLVNLDISSNQLKGLPDNALYN-LTALEVLN 115
P+ + + S+ + TK PE + + + L +++N++ L ++ LT L+ +N
Sbjct: 514 PHKCRCEANVVECSSLKLTKIPERIPQ--STAELRLNNNEISILEATGMFKKLTHLKKIN 571
Query: 116 LSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLANQELLIRPSLETLILDHCE 175
LS N + A + L L+ N+ +++ + + L L TL+L +
Sbjct: 572 LSNNKVSEI----EDGAFEGAASVSELHLTANQLESIRSGMFRGL---DGLRTLMLRNNR 624
Query: 176 INSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLNHN-ELMFLP 234
I+ IH S +GL N+R+L L N + + +L+SL N N N +L +L
Sbjct: 625 ISCIHNDS-FTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLG 683
Query: 235 SLTHLK--MSNNYRLELASSANNLFSQSLKYIDISYCN--------ILQPNLKGFPSLRK 284
+ ++ N R + + Q + + D C + +P +
Sbjct: 684 GWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR-CEEGQEEGGCLPRPQCPQECACLD 742
Query: 285 AIL--NHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAV 342
++ ++ +R L N TEL YLD + + + TF K L+ +DLS N+I+
Sbjct: 743 TVVRCSNKHLRALPKGIPKNVTEL-YLDGNQFTLVPGQLSTF---KYLQLVDLSNNKISS 798
Query: 343 IPEDSLLEMPSLTQLKLSRNYLSRVGHLRSM---SVTILDMSSCELNTIGKDSLEGLQSI 399
+ S M LT L LS N L + L S+ +L + +++T+ + + S+
Sbjct: 799 LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSL 858
Query: 400 VELDLSQNLL 409
L + N L
Sbjct: 859 SHLAIGANPL 868
Score = 49.6 bits (113), Expect = 4e-05
Identities = 48/170 (28%), Positives = 73/170 (42%), Gaps = 11/170 (6%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
LC C T +DC GL IP + +L ++ N T+ ++ + L L L +
Sbjct: 37 LCTCT--GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLME 94
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
NQ+ + A ++ LE L L+RN L++ P + L LDLS N Q +
Sbjct: 95 NQIGAVERGAFDDMKELERLRLNRNQ----LHMLPELLFQNNQALSRLDLSENAIQAIPR 150
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI 204
A + L+ L LD +I+ I L + VL LN N + I
Sbjct: 151 KAFRG---ATDLKNLQLDKNQISCIE-EGAFRALRGLEVLTLNNNNITTI 196
Score = 46.0 bits (104), Expect = 5e-04
Identities = 47/170 (27%), Positives = 73/170 (42%), Gaps = 9/170 (5%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL 97
C +DC +GLT IP L +T++ + N P + S L +D+S+NQ+
Sbjct: 286 CTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQI 345
Query: 98 KGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGNLAN 157
+ +A L +L L L N P V L++L L+ NK + A
Sbjct: 346 AEIAPDAFQGLRSLNSLVLYGNKITDL----PRGVFGGLYTLQLLLLNANKINCIRPDAF 401
Query: 158 QELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNL 207
Q+L +L L L +I S+ + + L I+ L L NP + NL
Sbjct: 402 QDL---QNLSLLSLYDNKIQSL-AKGTFTSLRAIQTLHLAQNPFICDCNL 447
Score = 45.6 bits (103), Expect = 7e-04
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 20/174 (11%)
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLN 226
E L L+ I IH ++ +GL +RVL+L N + ++ ++ L E LN
Sbjct: 64 ERLELNGNNITRIH-KNDFAGLKQLRVLQLMENQIGAVERGAFDDMKEL-----ERLRLN 117
Query: 227 HNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI 286
N+L LP L RL+L+ +A + +G L+
Sbjct: 118 RNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKA--------------FRGATDLKNLQ 163
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
L+ N + +E AF LE L L+NNNI ++ +F + L+ L N +
Sbjct: 164 LDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Score = 42.7 bits (96), Expect = 0.005
Identities = 21/88 (23%), Positives = 45/88 (51%), Gaps = 2/88 (2%)
Query: 38 RCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES--LSRLHNLVNLDISSN 95
+C + ++CS LT IP + +L ++NNE + + +L +L +++S+N
Sbjct: 516 KCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNN 575
Query: 96 QLKGLPDNALYNLTALEVLNLSRNYFDS 123
++ + D A ++ L+L+ N +S
Sbjct: 576 KVSEIEDGAFEGAASVSELHLTANQLES 603
>AL512424-3|CAI14257.1| 409|Homo sapiens slit homolog 1
(Drosophila) protein.
Length = 409
Score = 64.9 bits (151), Expect = 1e-09
Identities = 43/152 (28%), Positives = 77/152 (50%), Gaps = 5/152 (3%)
Query: 307 EYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIAVIPEDSLLEMPSLTQLKLSRNYLSR 366
E L+L+ NNI + + F GLK L+ L L N+I + + +M L +L+L+RN L
Sbjct: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 123
Query: 367 VGHL---RSMSVTILDMSSCELNTIGKDSLEGLQSIVELDLSQNLLSYIPDSI--SSNTL 421
+ L + +++ LD+S + I + + G + L L +N +S I + + L
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 183
Query: 422 KYLNLNYNRISSINNLTFFMLNRLTSLSVVGN 453
+ L LN N I++I +F + +L + + N
Sbjct: 184 EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSN 215
Score = 55.6 bits (128), Expect = 6e-07
Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 3/128 (2%)
Query: 281 SLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
+L + L+ N ++ + AF T+L+ L L N I+ + FR L+ L+ L L+ N I
Sbjct: 134 ALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNI 193
Query: 341 AVIPEDSLLEMPSLTQLKLSRNYLSRVGHLRSMSVTILDMSSCELNT--IGKDSLEGLQS 398
IP S MP L +L N+L HL +S + + L T G SL GL +
Sbjct: 194 TTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGL-N 252
Query: 399 IVELDLSQ 406
+ E+ S+
Sbjct: 253 VAEVQKSE 260
Score = 52.0 bits (119), Expect = 8e-06
Identities = 30/86 (34%), Positives = 43/86 (50%)
Query: 282 LRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEIA 341
L + LN N + L F NN L LDLS N I ++ FRG LK+L L N+I+
Sbjct: 111 LERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS 170
Query: 342 VIPEDSLLEMPSLTQLKLSRNYLSRV 367
I E + + L L L+ N ++ +
Sbjct: 171 CIEEGAFRALRGLEVLTLNNNNITTI 196
Score = 51.2 bits (117), Expect = 1e-05
Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 3/135 (2%)
Query: 278 GFPSLRKAILNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSW 337
G LR L N + +E AF + ELE L L+ N + L F+ + L LDLS
Sbjct: 83 GLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSE 142
Query: 338 NEIAVIPEDSLLEMPSLTQLKLSRNYLSRV--GHLRSM-SVTILDMSSCELNTIGKDSLE 394
N I IP + L L+L +N +S + G R++ + +L +++ + TI S
Sbjct: 143 NAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN 202
Query: 395 GLQSIVELDLSQNLL 409
+ + L N L
Sbjct: 203 HMPKLRTFRLHSNHL 217
Score = 49.6 bits (113), Expect = 4e-05
Identities = 48/170 (28%), Positives = 73/170 (42%), Gaps = 11/170 (6%)
Query: 36 LCRCNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPES-LSRLHNLVNLDISS 94
LC C T +DC GL IP + +L ++ N T+ ++ + L L L +
Sbjct: 37 LCTCT--GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLME 94
Query: 95 NQLKGLPDNALYNLTALEVLNLSRNYFDSWLNLNPNDVLLPATHLKILDLSFNKFQTMGN 154
NQ+ + A ++ LE L L+RN L++ P + L LDLS N Q +
Sbjct: 95 NQIGAVERGAFDDMKELERLRLNRNQ----LHMLPELLFQNNQALSRLDLSENAIQAIPR 150
Query: 155 LANQELLIRPSLETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRI 204
A + L+ L LD +I+ I L + VL LN N + I
Sbjct: 151 KAFRG---ATDLKNLQLDKNQISCIE-EGAFRALRGLEVLTLNNNNITTI 196
Score = 45.6 bits (103), Expect = 7e-04
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 20/174 (11%)
Query: 167 ETLILDHCEINSIHGRSPLSGLINIRVLKLNFNPLLRIQNLISSSLRSLFVSNCELTSLN 226
E L L+ I IH ++ +GL +RVL+L N + ++ ++ L E LN
Sbjct: 64 ERLELNGNNITRIH-KNDFAGLKQLRVLQLMENQIGAVERGAFDDMKEL-----ERLRLN 117
Query: 227 HNELMFLPSLTHLKMSNNYRLELASSANNLFSQSLKYIDISYCNILQPNLKGFPSLRKAI 286
N+L LP L RL+L+ +A + +G L+
Sbjct: 118 RNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKA--------------FRGATDLKNLQ 163
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHLDLSWNEI 340
L+ N + +E AF LE L L+NNNI ++ +F + L+ L N +
Sbjct: 164 LDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Score = 39.9 bits (89), Expect = 0.032
Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 39 CNLDKTDIDCSRRGLTDIPNGLGLQVTKLNISNNEFTKFPE-SLSRLHNLVNLDISSNQL 97
C +DC +GLT IP L +T++ + N P + S L +D+S+NQ+
Sbjct: 286 CTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQI 345
Query: 98 KGLPDNALYNLTALEVLN 115
+ +A L +L L+
Sbjct: 346 AEIAPDAFQGLRSLNSLH 363
Score = 36.7 bits (81), Expect = 0.30
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 287 LNHNMVRYLESNAFANNTELEYLDLSNNNIASLRYDTFRGLKMLKHL 333
L N ++ + AF+ +L +DLSNN IA + D F+GL+ L L
Sbjct: 316 LELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSL 362
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.135 0.397
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 97,159,421
Number of Sequences: 224733
Number of extensions: 3729694
Number of successful extensions: 25388
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 617
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 15961
Number of HSP's gapped (non-prelim): 4460
length of query: 753
length of database: 73,234,838
effective HSP length: 96
effective length of query: 657
effective length of database: 51,660,470
effective search space: 33940928790
effective search space used: 33940928790
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 69 (31.9 bits)
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