Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002526-TA|BGIBMGA002526-PA|IPR006025|Peptidase M,
neutral zinc metallopeptidases, zinc-binding site, IPR001548|Peptidase
M2, peptidyl-dipeptidase A
(648 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X16295-1|CAA34362.1| 732|Homo sapiens peptidyl dipeptidase I p... 595 e-169
M26657-1|AAA60611.1| 732|Homo sapiens DCP1 protein. 595 e-169
AF118569-2|AAD28561.1| 732|Homo sapiens angiotensin I convertin... 595 e-169
BC036375-1|AAH36375.1| 739|Homo sapiens angiotensin I convertin... 593 e-169
J04144-1|AAA51684.1| 1306|Homo sapiens DCP1 protein. 592 e-168
AY436326-1|AAR03504.1| 1306|Homo sapiens angiotensin I convertin... 592 e-168
AF118569-1|AAD28560.1| 1306|Homo sapiens angiotensin I convertin... 592 e-168
AB208971-1|BAD92208.1| 1247|Homo sapiens angiotensin I convertin... 592 e-168
M26658-1|AAA60612.1| 694|Homo sapiens DCP1 protein. 578 e-164
BC048094-1|AAH48094.2| 805|Homo sapiens angiotensin I convertin... 431 e-120
BC039902-1|AAH39902.1| 805|Homo sapiens angiotensin I convertin... 431 e-120
AY623811-1|AAT45083.1| 805|Homo sapiens angiotensin converting ... 431 e-120
AY217547-1|AAO25651.1| 805|Homo sapiens angiotensin I convertin... 431 e-120
AL110224-1|CAB53682.1| 804|Homo sapiens hypothetical protein pr... 431 e-120
AF291820-1|AAF99721.1| 805|Homo sapiens ACE-related carboxypept... 431 e-120
AF241254-1|AAF78220.1| 805|Homo sapiens angiotensin converting ... 431 e-120
AB193260-1|BAD99267.1| 805|Homo sapiens angiotensin-converting ... 431 e-120
AB193259-1|BAD99266.1| 805|Homo sapiens angiotensin-converting ... 431 e-120
AB046569-1|BAB40370.1| 805|Homo sapiens ACE2 protein. 431 e-120
AY358714-1|AAQ89076.1| 555|Homo sapiens ACE2 protein. 379 e-104
S81361-1|AAD14360.1| 135|Homo sapiens angiotensin I-converting ... 139 3e-32
AY999974-1|ABA39230.1| 47|Homo sapiens angiotensin I convertin... 45 7e-04
AY999973-1|ABA39229.1| 32|Homo sapiens angiotensin I convertin... 42 0.009
AY999972-1|ABA39228.1| 32|Homo sapiens angiotensin I convertin... 42 0.009
DQ457018-1|ABF00475.1| 42|Homo sapiens angiotensin I convertin... 41 0.012
DQ458794-1|ABE96829.1| 41|Homo sapiens angiotensin I convertin... 37 0.26
M86868-1|AAA52510.1| 465|Homo sapiens gamma-amino butyric acid ... 31 9.6
BC130354-1|AAI30355.1| 465|Homo sapiens gamma-aminobutyric acid... 31 9.6
BC130352-1|AAI30353.1| 465|Homo sapiens gamma-aminobutyric acid... 31 9.6
AL121833-2|CAC07339.1| 465|Homo sapiens gamma-aminobutyric acid... 31 9.6
>X16295-1|CAA34362.1| 732|Homo sapiens peptidyl dipeptidase I
protein.
Length = 732
Score = 595 bits (1470), Expect = e-169
Identities = 276/600 (46%), Positives = 392/600 (65%), Gaps = 10/600 (1%)
Query: 22 TQGRDPDLEAREHEAREYMLHLDKATGLRKNRASLAEWEYTSNITKENEEKSIQTHLELS 81
T + P+L E EA +++ D+ + + N + A W Y +NIT E + +Q +++++
Sbjct: 61 TSAQSPNLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIA 120
Query: 82 RQEKAAWEETKMYGWQDFQDFTLRRMFKKYSQLGVAALPDDKFQALMRTVSGMESNYATA 141
+ + + Q+ T++R+ KK L AALP + + + + ME+ Y+ A
Sbjct: 121 NHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVA 180
Query: 142 KICSYKNESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNE 201
+C + N S C L LEP++T + +TS+ E+L AW W + AG + + YV L N+
Sbjct: 181 TVC-HPNGS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQ 237
Query: 202 AAKLNGFDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSA 261
AA+LNG+ + + W+S YE P E+ L +L+++++PLY LHAYVR+ L YG + ++
Sbjct: 238 AARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINL 297
Query: 262 RGPIPAHLLGNMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSL 321
GPIPAHLLGNMWAQTW+NI P+P +D T+AM Q +TP +MF+ +D+FF SL
Sbjct: 298 EGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSL 357
Query: 322 NLTAMPEKFWKNSIIEKPTD-REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMG 380
L +P +FW S++EKPTD RE+VCHASAWDF++G+DFRIKQCTTV+ E HHEMG
Sbjct: 358 GLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMG 417
Query: 381 HIQYYLQYRDQPVVFRDGANQGFHEAVGDTIALSVSSPKHLRRVGLATGDAEDEQTEINQ 440
HIQY++QY+D PV R+GAN GFHEA+GD +ALSVS+PKHL + L + + ++ +IN
Sbjct: 418 HIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINF 477
Query: 441 LYKMGIDKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDF 500
L KM +DKIAF+PF+Y +D +R+ VF E+YN +W LR + QG+ PPV RT+ DF
Sbjct: 478 LMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDF 537
Query: 501 DAAAKYHVSANVEYARYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGN 560
D AK+H+ ++V Y RY+VSFIIQFQFH ALCQ AG G +K CDIYQS AG
Sbjct: 538 DPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH--TGPLHK----CDIYQSKEAGQ 591
Query: 561 ALANMLKMGSSKPWPDAMEALTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTN 620
LA +K+G S+PWP+AM+ +TGQ M A +L YF+PL DWLR EN+ GE +GW N
Sbjct: 592 RLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYN 651
>M26657-1|AAA60611.1| 732|Homo sapiens DCP1 protein.
Length = 732
Score = 595 bits (1470), Expect = e-169
Identities = 276/600 (46%), Positives = 392/600 (65%), Gaps = 10/600 (1%)
Query: 22 TQGRDPDLEAREHEAREYMLHLDKATGLRKNRASLAEWEYTSNITKENEEKSIQTHLELS 81
T + P+L E EA +++ D+ + + N + A W Y +NIT E + +Q +++++
Sbjct: 61 TSAQSPNLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIA 120
Query: 82 RQEKAAWEETKMYGWQDFQDFTLRRMFKKYSQLGVAALPDDKFQALMRTVSGMESNYATA 141
+ + + Q+ T++R+ KK L AALP + + + + ME+ Y+ A
Sbjct: 121 NHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVA 180
Query: 142 KICSYKNESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNE 201
+C + N S C L LEP++T + +TS+ E+L AW W + AG + + YV L N+
Sbjct: 181 TVC-HPNGS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQ 237
Query: 202 AAKLNGFDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSA 261
AA+LNG+ + + W+S YE P E+ L +L+++++PLY LHAYVR+ L YG + ++
Sbjct: 238 AARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINL 297
Query: 262 RGPIPAHLLGNMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSL 321
GPIPAHLLGNMWAQTW+NI P+P +D T+AM Q +TP +MF+ +D+FF SL
Sbjct: 298 EGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSL 357
Query: 322 NLTAMPEKFWKNSIIEKPTD-REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMG 380
L +P +FW S++EKPTD RE+VCHASAWDF++G+DFRIKQCTTV+ E HHEMG
Sbjct: 358 GLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMG 417
Query: 381 HIQYYLQYRDQPVVFRDGANQGFHEAVGDTIALSVSSPKHLRRVGLATGDAEDEQTEINQ 440
HIQY++QY+D PV R+GAN GFHEA+GD +ALSVS+PKHL + L + + ++ +IN
Sbjct: 418 HIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINF 477
Query: 441 LYKMGIDKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDF 500
L KM +DKIAF+PF+Y +D +R+ VF E+YN +W LR + QG+ PPV RT+ DF
Sbjct: 478 LMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDF 537
Query: 501 DAAAKYHVSANVEYARYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGN 560
D AK+H+ ++V Y RY+VSFIIQFQFH ALCQ AG G +K CDIYQS AG
Sbjct: 538 DPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH--TGPLHK----CDIYQSKEAGQ 591
Query: 561 ALANMLKMGSSKPWPDAMEALTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTN 620
LA +K+G S+PWP+AM+ +TGQ M A +L YF+PL DWLR EN+ GE +GW N
Sbjct: 592 RLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYN 651
>AF118569-2|AAD28561.1| 732|Homo sapiens angiotensin I converting
enzyme precursor protein.
Length = 732
Score = 595 bits (1470), Expect = e-169
Identities = 276/600 (46%), Positives = 392/600 (65%), Gaps = 10/600 (1%)
Query: 22 TQGRDPDLEAREHEAREYMLHLDKATGLRKNRASLAEWEYTSNITKENEEKSIQTHLELS 81
T + P+L E EA +++ D+ + + N + A W Y +NIT E + +Q +++++
Sbjct: 61 TSAQSPNLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIA 120
Query: 82 RQEKAAWEETKMYGWQDFQDFTLRRMFKKYSQLGVAALPDDKFQALMRTVSGMESNYATA 141
+ + + Q+ T++R+ KK L AALP + + + + ME+ Y+ A
Sbjct: 121 NHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVA 180
Query: 142 KICSYKNESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNE 201
+C + N S C L LEP++T + +TS+ E+L AW W + AG + + YV L N+
Sbjct: 181 TVC-HPNGS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQ 237
Query: 202 AAKLNGFDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSA 261
AA+LNG+ + + W+S YE P E+ L +L+++++PLY LHAYVR+ L YG + ++
Sbjct: 238 AARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINL 297
Query: 262 RGPIPAHLLGNMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSL 321
GPIPAHLLGNMWAQTW+NI P+P +D T+AM Q +TP +MF+ +D+FF SL
Sbjct: 298 EGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSL 357
Query: 322 NLTAMPEKFWKNSIIEKPTD-REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMG 380
L +P +FW S++EKPTD RE+VCHASAWDF++G+DFRIKQCTTV+ E HHEMG
Sbjct: 358 GLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMG 417
Query: 381 HIQYYLQYRDQPVVFRDGANQGFHEAVGDTIALSVSSPKHLRRVGLATGDAEDEQTEINQ 440
HIQY++QY+D PV R+GAN GFHEA+GD +ALSVS+PKHL + L + + ++ +IN
Sbjct: 418 HIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINF 477
Query: 441 LYKMGIDKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDF 500
L KM +DKIAF+PF+Y +D +R+ VF E+YN +W LR + QG+ PPV RT+ DF
Sbjct: 478 LMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDF 537
Query: 501 DAAAKYHVSANVEYARYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGN 560
D AK+H+ ++V Y RY+VSFIIQFQFH ALCQ AG G +K CDIYQS AG
Sbjct: 538 DPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH--TGPLHK----CDIYQSKEAGQ 591
Query: 561 ALANMLKMGSSKPWPDAMEALTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTN 620
LA +K+G S+PWP+AM+ +TGQ M A +L YF+PL DWLR EN+ GE +GW N
Sbjct: 592 RLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYN 651
>BC036375-1|AAH36375.1| 739|Homo sapiens angiotensin I converting
enzyme (peptidyl-dipeptidase A) 1 protein.
Length = 739
Score = 593 bits (1465), Expect = e-169
Identities = 275/597 (46%), Positives = 391/597 (65%), Gaps = 10/597 (1%)
Query: 25 RDPDLEAREHEAREYMLHLDKATGLRKNRASLAEWEYTSNITKENEEKSIQTHLELSRQE 84
+ P+L E EA +++ D+ + + N + A W Y +NIT E + +Q +++++
Sbjct: 64 QSPNLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHT 123
Query: 85 KAAWEETKMYGWQDFQDFTLRRMFKKYSQLGVAALPDDKFQALMRTVSGMESNYATAKIC 144
+ + + Q+ T++R+ KK L AALP + + + + ME+ Y+ A +C
Sbjct: 124 LKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC 183
Query: 145 SYKNESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNEAAK 204
+ N S C L LEP++T + +TS+ E+L AW W + AG + + YV L N+AA+
Sbjct: 184 -HPNGS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAAR 240
Query: 205 LNGFDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGP 264
LNG+ + + W+S YE P E+ L +L+++++PLY LHAYVR+ L YG + ++ GP
Sbjct: 241 LNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGP 300
Query: 265 IPAHLLGNMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLT 324
IPAHLLGNMWAQTW+NI P+P +D T+AM Q +TP +MF+ +D+FF SL L
Sbjct: 301 IPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLL 360
Query: 325 AMPEKFWKNSIIEKPTD-REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQ 383
+P +FW S++EKPTD RE+VCHASAWDF++G+DFRIKQCTTV+ E HHEMGHIQ
Sbjct: 361 PVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQ 420
Query: 384 YYLQYRDQPVVFRDGANQGFHEAVGDTIALSVSSPKHLRRVGLATGDAEDEQTEINQLYK 443
Y++QY+D PV R+GAN GFHEA+GD +ALSVS+PKHL + L + + ++ +IN L K
Sbjct: 421 YFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMK 480
Query: 444 MGIDKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAA 503
M +DKIAF+PF+Y +D +R+ VF E+YN +W LR + QG+ PPV RT+ DFD
Sbjct: 481 MALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPG 540
Query: 504 AKYHVSANVEYARYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALA 563
AK+H+ ++V Y RY+VSFIIQFQFH ALCQ AG G +K CDIYQS AG LA
Sbjct: 541 AKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH--TGPLHK----CDIYQSKEAGQRLA 594
Query: 564 NMLKMGSSKPWPDAMEALTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTN 620
+K+G S+PWP+AM+ +TGQ M A +L YF+PL DWLR EN+ GE +GW N
Sbjct: 595 TAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYN 651
>J04144-1|AAA51684.1| 1306|Homo sapiens DCP1 protein.
Length = 1306
Score = 592 bits (1462), Expect = e-168
Identities = 275/594 (46%), Positives = 389/594 (65%), Gaps = 10/594 (1%)
Query: 28 DLEAREHEAREYMLHLDKATGLRKNRASLAEWEYTSNITKENEEKSIQTHLELSRQEKAA 87
DL E EA +++ D+ + + N + A W Y +NIT E + +Q +++++
Sbjct: 641 DLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKY 700
Query: 88 WEETKMYGWQDFQDFTLRRMFKKYSQLGVAALPDDKFQALMRTVSGMESNYATAKICSYK 147
+ + + Q+ T++R+ KK L AALP + + + + ME+ Y+ A +C +
Sbjct: 701 GTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC-HP 759
Query: 148 NESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNG 207
N S C L LEP++T + +TS+ E+L AW W + AG + + YV L N+AA+LNG
Sbjct: 760 NGS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNG 817
Query: 208 FDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPA 267
+ + + W+S YE P E+ L +L+++++PLY LHAYVR+ L YG + ++ GPIPA
Sbjct: 818 YVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPA 877
Query: 268 HLLGNMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMP 327
HLLGNMWAQTW+NI P+P +D T+AM Q +TP +MF+ +D+FF SL L +P
Sbjct: 878 HLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVP 937
Query: 328 EKFWKNSIIEKPTD-REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYL 386
+FW S++EKPTD RE+VCHASAWDF++G+DFRIKQCTTV+ E HHEMGHIQY++
Sbjct: 938 PEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFM 997
Query: 387 QYRDQPVVFRDGANQGFHEAVGDTIALSVSSPKHLRRVGLATGDAEDEQTEINQLYKMGI 446
QY+D PV R+GAN GFHEA+GD +ALSVS+PKHL + L + + ++ +IN L KM +
Sbjct: 998 QYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMAL 1057
Query: 447 DKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKY 506
DKIAF+PF+Y +D +R+ VF E+YN +W LR + QG+ PPV RT+ DFD AK+
Sbjct: 1058 DKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKF 1117
Query: 507 HVSANVEYARYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANML 566
H+ ++V Y RY+VSFIIQFQFH ALCQ AG G +K CDIYQS AG LA +
Sbjct: 1118 HIPSSVPYIRYFVSFIIQFQFHEALCQAAGH--TGPLHK----CDIYQSKEAGQRLATAM 1171
Query: 567 KMGSSKPWPDAMEALTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTN 620
K+G S+PWP+AM+ +TGQ M A +L YF+PL DWLR EN+ GE +GW N
Sbjct: 1172 KLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYN 1225
Score = 560 bits (1382), Expect = e-159
Identities = 266/565 (47%), Positives = 363/565 (64%), Gaps = 13/565 (2%)
Query: 57 AEWEYTSNITKENEEKSIQTHLELSRQEKAAWEET--KMYG--WQDFQDFTLRRMFKKYS 112
A W + +NIT EN + + L LS++ AW + ++Y WQ+F D LRR+
Sbjct: 67 ASWAHDTNITAENARRQEEAAL-LSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVR 125
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
LG A LP K Q +S M Y+TAK+C + C SL+P++T I ++S+
Sbjct: 126 TLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATC-WSLDPDLTNILASSRSYAM 184
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFEEQLAKLW 232
L AW WHNAAG K + D+ L NEA K +GF + +W+S Y P FE+ L L+
Sbjct: 185 LLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLY 244
Query: 233 EDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIESFTRPYPDKK 292
+ ++PLY LHA+VR+ L +YGD+ ++ RGPIPAHLLG+MWAQ+W NI P+PDK
Sbjct: 245 QQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKP 304
Query: 293 EIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD-REIVCHASAW 351
+DVT M Q + MF++++EFF SL L+ MP +FW+ S++EKP D RE+VCHASAW
Sbjct: 305 NLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAW 364
Query: 352 DFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQGFHEAVGDTI 411
DF++ +DFRIKQCT V + T HHEMGHIQYYLQY+D PV R GAN GFHEA+GD +
Sbjct: 365 DFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVL 424
Query: 412 ALSVSSPKHLRRVGLATGDAEDEQTEINQLYKMGIDKIAFLPFAYTLDLFRYGVFRRKTL 471
ALSVS+P+HL ++GL D +++IN L KM ++KIAFLPF Y +D +R+GVF +T
Sbjct: 425 ALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTP 484
Query: 472 PEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVSFIIQFQFHRAL 531
P YN +W LR + QG+ PPV R E FDA AK+HV Y RY+VSF++QFQFH AL
Sbjct: 485 PSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEAL 544
Query: 532 CQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEALTGQREMKADG 591
C+ AG L CDIY+S AG L +L+ GSS+PW + ++ + G + A
Sbjct: 545 CKEAGYEG------PLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQP 598
Query: 592 LLEYFRPLHDWLRAENQRTGEHIGW 616
LL+YF+P+ WL+ +NQ+ GE +GW
Sbjct: 599 LLKYFQPVTQWLQEQNQQNGEVLGW 623
>AY436326-1|AAR03504.1| 1306|Homo sapiens angiotensin I converting
enzyme (peptidyl-dipeptidase A) 1 protein.
Length = 1306
Score = 592 bits (1462), Expect = e-168
Identities = 275/594 (46%), Positives = 389/594 (65%), Gaps = 10/594 (1%)
Query: 28 DLEAREHEAREYMLHLDKATGLRKNRASLAEWEYTSNITKENEEKSIQTHLELSRQEKAA 87
DL E EA +++ D+ + + N + A W Y +NIT E + +Q +++++
Sbjct: 641 DLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKY 700
Query: 88 WEETKMYGWQDFQDFTLRRMFKKYSQLGVAALPDDKFQALMRTVSGMESNYATAKICSYK 147
+ + + Q+ T++R+ KK L AALP + + + + ME+ Y+ A +C +
Sbjct: 701 GTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC-HP 759
Query: 148 NESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNG 207
N S C L LEP++T + +TS+ E+L AW W + AG + + YV L N+AA+LNG
Sbjct: 760 NGS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNG 817
Query: 208 FDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPA 267
+ + + W+S YE P E+ L +L+++++PLY LHAYVR+ L YG + ++ GPIPA
Sbjct: 818 YVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPA 877
Query: 268 HLLGNMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMP 327
HLLGNMWAQTW+NI P+P +D T+AM Q +TP +MF+ +D+FF SL L +P
Sbjct: 878 HLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVP 937
Query: 328 EKFWKNSIIEKPTD-REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYL 386
+FW S++EKPTD RE+VCHASAWDF++G+DFRIKQCTTV+ E HHEMGHIQY++
Sbjct: 938 PEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFM 997
Query: 387 QYRDQPVVFRDGANQGFHEAVGDTIALSVSSPKHLRRVGLATGDAEDEQTEINQLYKMGI 446
QY+D PV R+GAN GFHEA+GD +ALSVS+PKHL + L + + ++ +IN L KM +
Sbjct: 998 QYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMAL 1057
Query: 447 DKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKY 506
DKIAF+PF+Y +D +R+ VF E+YN +W LR + QG+ PPV RT+ DFD AK+
Sbjct: 1058 DKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKF 1117
Query: 507 HVSANVEYARYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANML 566
H+ ++V Y RY+VSFIIQFQFH ALCQ AG G +K CDIYQS AG LA +
Sbjct: 1118 HIPSSVPYIRYFVSFIIQFQFHEALCQAAGH--TGPLHK----CDIYQSKEAGQRLATAM 1171
Query: 567 KMGSSKPWPDAMEALTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTN 620
K+G S+PWP+AM+ +TGQ M A +L YF+PL DWLR EN+ GE +GW N
Sbjct: 1172 KLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYN 1225
Score = 560 bits (1382), Expect = e-159
Identities = 266/565 (47%), Positives = 363/565 (64%), Gaps = 13/565 (2%)
Query: 57 AEWEYTSNITKENEEKSIQTHLELSRQEKAAWEET--KMYG--WQDFQDFTLRRMFKKYS 112
A W + +NIT EN + + L LS++ AW + ++Y WQ+F D LRR+
Sbjct: 67 ASWAHDTNITAENARRQEEAAL-LSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVR 125
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
LG A LP K Q +S M Y+TAK+C + C SL+P++T I ++S+
Sbjct: 126 TLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATC-WSLDPDLTNILASSRSYAM 184
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFEEQLAKLW 232
L AW WHNAAG K + D+ L NEA K +GF + +W+S Y P FE+ L L+
Sbjct: 185 LLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLY 244
Query: 233 EDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIESFTRPYPDKK 292
+ ++PLY LHA+VR+ L +YGD+ ++ RGPIPAHLLG+MWAQ+W NI P+PDK
Sbjct: 245 QQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKP 304
Query: 293 EIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD-REIVCHASAW 351
+DVT M Q + MF++++EFF SL L+ MP +FW+ S++EKP D RE+VCHASAW
Sbjct: 305 NLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAW 364
Query: 352 DFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQGFHEAVGDTI 411
DF++ +DFRIKQCT V + T HHEMGHIQYYLQY+D PV R GAN GFHEA+GD +
Sbjct: 365 DFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVL 424
Query: 412 ALSVSSPKHLRRVGLATGDAEDEQTEINQLYKMGIDKIAFLPFAYTLDLFRYGVFRRKTL 471
ALSVS+P+HL ++GL D +++IN L KM ++KIAFLPF Y +D +R+GVF +T
Sbjct: 425 ALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTP 484
Query: 472 PEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVSFIIQFQFHRAL 531
P YN +W LR + QG+ PPV R E FDA AK+HV Y RY+VSF++QFQFH AL
Sbjct: 485 PSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEAL 544
Query: 532 CQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEALTGQREMKADG 591
C+ AG L CDIY+S AG L +L+ GSS+PW + ++ + G + A
Sbjct: 545 CKEAGYEG------PLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQP 598
Query: 592 LLEYFRPLHDWLRAENQRTGEHIGW 616
LL+YF+P+ WL+ +NQ+ GE +GW
Sbjct: 599 LLKYFQPVTQWLQEQNQQNGEVLGW 623
>AF118569-1|AAD28560.1| 1306|Homo sapiens angiotensin I converting
enzyme precursor protein.
Length = 1306
Score = 592 bits (1462), Expect = e-168
Identities = 275/594 (46%), Positives = 389/594 (65%), Gaps = 10/594 (1%)
Query: 28 DLEAREHEAREYMLHLDKATGLRKNRASLAEWEYTSNITKENEEKSIQTHLELSRQEKAA 87
DL E EA +++ D+ + + N + A W Y +NIT E + +Q +++++
Sbjct: 641 DLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKY 700
Query: 88 WEETKMYGWQDFQDFTLRRMFKKYSQLGVAALPDDKFQALMRTVSGMESNYATAKICSYK 147
+ + + Q+ T++R+ KK L AALP + + + + ME+ Y+ A +C +
Sbjct: 701 GTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC-HP 759
Query: 148 NESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNG 207
N S C L LEP++T + +TS+ E+L AW W + AG + + YV L N+AA+LNG
Sbjct: 760 NGS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNG 817
Query: 208 FDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPA 267
+ + + W+S YE P E+ L +L+++++PLY LHAYVR+ L YG + ++ GPIPA
Sbjct: 818 YVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPA 877
Query: 268 HLLGNMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMP 327
HLLGNMWAQTW+NI P+P +D T+AM Q +TP +MF+ +D+FF SL L +P
Sbjct: 878 HLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVP 937
Query: 328 EKFWKNSIIEKPTD-REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYL 386
+FW S++EKPTD RE+VCHASAWDF++G+DFRIKQCTTV+ E HHEMGHIQY++
Sbjct: 938 PEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFM 997
Query: 387 QYRDQPVVFRDGANQGFHEAVGDTIALSVSSPKHLRRVGLATGDAEDEQTEINQLYKMGI 446
QY+D PV R+GAN GFHEA+GD +ALSVS+PKHL + L + + ++ +IN L KM +
Sbjct: 998 QYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMAL 1057
Query: 447 DKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKY 506
DKIAF+PF+Y +D +R+ VF E+YN +W LR + QG+ PPV RT+ DFD AK+
Sbjct: 1058 DKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKF 1117
Query: 507 HVSANVEYARYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANML 566
H+ ++V Y RY+VSFIIQFQFH ALCQ AG G +K CDIYQS AG LA +
Sbjct: 1118 HIPSSVPYIRYFVSFIIQFQFHEALCQAAGH--TGPLHK----CDIYQSKEAGQRLATAM 1171
Query: 567 KMGSSKPWPDAMEALTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTN 620
K+G S+PWP+AM+ +TGQ M A +L YF+PL DWLR EN+ GE +GW N
Sbjct: 1172 KLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYN 1225
Score = 560 bits (1382), Expect = e-159
Identities = 266/565 (47%), Positives = 363/565 (64%), Gaps = 13/565 (2%)
Query: 57 AEWEYTSNITKENEEKSIQTHLELSRQEKAAWEET--KMYG--WQDFQDFTLRRMFKKYS 112
A W + +NIT EN + + L LS++ AW + ++Y WQ+F D LRR+
Sbjct: 67 ASWAHDTNITAENARRQEEAAL-LSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVR 125
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
LG A LP K Q +S M Y+TAK+C + C SL+P++T I ++S+
Sbjct: 126 TLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATC-WSLDPDLTNILASSRSYAM 184
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFEEQLAKLW 232
L AW WHNAAG K + D+ L NEA K +GF + +W+S Y P FE+ L L+
Sbjct: 185 LLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLY 244
Query: 233 EDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIESFTRPYPDKK 292
+ ++PLY LHA+VR+ L +YGD+ ++ RGPIPAHLLG+MWAQ+W NI P+PDK
Sbjct: 245 QQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKP 304
Query: 293 EIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD-REIVCHASAW 351
+DVT M Q + MF++++EFF SL L+ MP +FW+ S++EKP D RE+VCHASAW
Sbjct: 305 NLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAW 364
Query: 352 DFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQGFHEAVGDTI 411
DF++ +DFRIKQCT V + T HHEMGHIQYYLQY+D PV R GAN GFHEA+GD +
Sbjct: 365 DFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVL 424
Query: 412 ALSVSSPKHLRRVGLATGDAEDEQTEINQLYKMGIDKIAFLPFAYTLDLFRYGVFRRKTL 471
ALSVS+P+HL ++GL D +++IN L KM ++KIAFLPF Y +D +R+GVF +T
Sbjct: 425 ALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTP 484
Query: 472 PEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVSFIIQFQFHRAL 531
P YN +W LR + QG+ PPV R E FDA AK+HV Y RY+VSF++QFQFH AL
Sbjct: 485 PSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEAL 544
Query: 532 CQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEALTGQREMKADG 591
C+ AG L CDIY+S AG L +L+ GSS+PW + ++ + G + A
Sbjct: 545 CKEAGYEG------PLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQP 598
Query: 592 LLEYFRPLHDWLRAENQRTGEHIGW 616
LL+YF+P+ WL+ +NQ+ GE +GW
Sbjct: 599 LLKYFQPVTQWLQEQNQQNGEVLGW 623
>AB208971-1|BAD92208.1| 1247|Homo sapiens angiotensin I converting
enzyme isoform 1 precursor variant protein.
Length = 1247
Score = 592 bits (1462), Expect = e-168
Identities = 275/594 (46%), Positives = 389/594 (65%), Gaps = 10/594 (1%)
Query: 28 DLEAREHEAREYMLHLDKATGLRKNRASLAEWEYTSNITKENEEKSIQTHLELSRQEKAA 87
DL E EA +++ D+ + + N + A W Y +NIT E + +Q +++++
Sbjct: 649 DLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKY 708
Query: 88 WEETKMYGWQDFQDFTLRRMFKKYSQLGVAALPDDKFQALMRTVSGMESNYATAKICSYK 147
+ + + Q+ T++R+ KK L AALP + + + + ME+ Y+ A +C +
Sbjct: 709 GTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC-HP 767
Query: 148 NESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNG 207
N S C L LEP++T + +TS+ E+L AW W + AG + + YV L N+AA+LNG
Sbjct: 768 NGS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNG 825
Query: 208 FDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPA 267
+ + + W+S YE P E+ L +L+++++PLY LHAYVR+ L YG + ++ GPIPA
Sbjct: 826 YVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPA 885
Query: 268 HLLGNMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMP 327
HLLGNMWAQTW+NI P+P +D T+AM Q +TP +MF+ +D+FF SL L +P
Sbjct: 886 HLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVP 945
Query: 328 EKFWKNSIIEKPTD-REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYL 386
+FW S++EKPTD RE+VCHASAWDF++G+DFRIKQCTTV+ E HHEMGHIQY++
Sbjct: 946 PEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFM 1005
Query: 387 QYRDQPVVFRDGANQGFHEAVGDTIALSVSSPKHLRRVGLATGDAEDEQTEINQLYKMGI 446
QY+D PV R+GAN GFHEA+GD +ALSVS+PKHL + L + + ++ +IN L KM +
Sbjct: 1006 QYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMAL 1065
Query: 447 DKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKY 506
DKIAF+PF+Y +D +R+ VF E+YN +W LR + QG+ PPV RT+ DFD AK+
Sbjct: 1066 DKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKF 1125
Query: 507 HVSANVEYARYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANML 566
H+ ++V Y RY+VSFIIQFQFH ALCQ AG G +K CDIYQS AG LA +
Sbjct: 1126 HIPSSVPYIRYFVSFIIQFQFHEALCQAAGH--TGPLHK----CDIYQSKEAGQRLATAM 1179
Query: 567 KMGSSKPWPDAMEALTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTN 620
K+G S+PWP+AM+ +TGQ M A +L YF+PL DWLR EN+ GE +GW N
Sbjct: 1180 KLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYN 1233
Score = 560 bits (1382), Expect = e-159
Identities = 266/565 (47%), Positives = 363/565 (64%), Gaps = 13/565 (2%)
Query: 57 AEWEYTSNITKENEEKSIQTHLELSRQEKAAWEET--KMYG--WQDFQDFTLRRMFKKYS 112
A W + +NIT EN + + L LS++ AW + ++Y WQ+F D LRR+
Sbjct: 75 ASWAHDTNITAENARRQEEAAL-LSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVR 133
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
LG A LP K Q +S M Y+TAK+C + C SL+P++T I ++S+
Sbjct: 134 TLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATC-WSLDPDLTNILASSRSYAM 192
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFEEQLAKLW 232
L AW WHNAAG K + D+ L NEA K +GF + +W+S Y P FE+ L L+
Sbjct: 193 LLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLY 252
Query: 233 EDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIESFTRPYPDKK 292
+ ++PLY LHA+VR+ L +YGD+ ++ RGPIPAHLLG+MWAQ+W NI P+PDK
Sbjct: 253 QQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKP 312
Query: 293 EIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD-REIVCHASAW 351
+DVT M Q + MF++++EFF SL L+ MP +FW+ S++EKP D RE+VCHASAW
Sbjct: 313 NLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAW 372
Query: 352 DFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQGFHEAVGDTI 411
DF++ +DFRIKQCT V + T HHEMGHIQYYLQY+D PV R GAN GFHEA+GD +
Sbjct: 373 DFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVL 432
Query: 412 ALSVSSPKHLRRVGLATGDAEDEQTEINQLYKMGIDKIAFLPFAYTLDLFRYGVFRRKTL 471
ALSVS+P+HL ++GL D +++IN L KM ++KIAFLPF Y +D +R+GVF +T
Sbjct: 433 ALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTP 492
Query: 472 PEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVSFIIQFQFHRAL 531
P YN +W LR + QG+ PPV R E FDA AK+HV Y RY+VSF++QFQFH AL
Sbjct: 493 PSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEAL 552
Query: 532 CQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEALTGQREMKADG 591
C+ AG L CDIY+S AG L +L+ GSS+PW + ++ + G + A
Sbjct: 553 CKEAGYEG------PLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQP 606
Query: 592 LLEYFRPLHDWLRAENQRTGEHIGW 616
LL+YF+P+ WL+ +NQ+ GE +GW
Sbjct: 607 LLKYFQPVTQWLQEQNQQNGEVLGW 631
>M26658-1|AAA60612.1| 694|Homo sapiens DCP1 protein.
Length = 694
Score = 578 bits (1427), Expect = e-164
Identities = 267/566 (47%), Positives = 375/566 (66%), Gaps = 10/566 (1%)
Query: 56 LAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYSQLG 115
+A Y +NIT E + +Q +++++ + + + Q+ T++R+ KK L
Sbjct: 57 IATKNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLE 116
Query: 116 VAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEELKH 175
AALP + + + + ME+ Y+ A +C + N S C L LEP++T + +TS+ E+L
Sbjct: 117 RAALPAQELEEYNKILLDMETTYSVATVC-HPNGS-C-LQLEPDLTNVMATSRKYEDLLW 173
Query: 176 AWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFEEQLAKLWEDV 235
AW W + AG + + YV L N+AA+LNG+ + + W+S YE P E+ L +L++++
Sbjct: 174 AWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQEL 233
Query: 236 KPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIESFTRPYPDKKEID 295
+PLY LHAYVR+ L YG + ++ GPIPAHLLGNMWAQTW+NI P+P +D
Sbjct: 234 QPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMD 293
Query: 296 VTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD-REIVCHASAWDFF 354
T+AM Q +TP +MF+ +D+FF SL L +P +FW S++EKPTD RE+VCHASAWDF+
Sbjct: 294 TTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFY 353
Query: 355 DGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQGFHEAVGDTIALS 414
+G+DFRIKQCTTV+ E HHEMGHIQY++QY+D PV R+GAN GFHEA+GD +ALS
Sbjct: 354 NGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALS 413
Query: 415 VSSPKHLRRVGLATGDAEDEQTEINQLYKMGIDKIAFLPFAYTLDLFRYGVFRRKTLPED 474
VS+PKHL + L + + ++ +IN L KM +DKIAF+PF+Y +D +R+ VF E+
Sbjct: 414 VSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKEN 473
Query: 475 YNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVSFIIQFQFHRALCQL 534
YN +W LR + QG+ PPV RT+ DFD AK+H+ ++V Y RY+VSFIIQFQFH ALCQ
Sbjct: 474 YNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQA 533
Query: 535 AGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEALTGQREMKADGLLE 594
AG G +K CDIYQS AG LA +K+G S+PWP+AM+ +TGQ M A +L
Sbjct: 534 AGH--TGPLHK----CDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLS 587
Query: 595 YFRPLHDWLRAENQRTGEHIGWEPTN 620
YF+PL DWLR EN+ GE +GW N
Sbjct: 588 YFKPLLDWLRTENELHGEKLGWPQYN 613
>BC048094-1|AAH48094.2| 805|Homo sapiens angiotensin I converting
enzyme (peptidyl-dipeptidase A) 2 protein.
Length = 805
Score = 431 bits (1063), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 630
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 631 KAYEWNDN 638
>BC039902-1|AAH39902.1| 805|Homo sapiens angiotensin I converting
enzyme (peptidyl-dipeptidase A) 2 protein.
Length = 805
Score = 431 bits (1063), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 630
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 631 KAYEWNDN 638
>AY623811-1|AAT45083.1| 805|Homo sapiens angiotensin converting
enzyme 2 protein.
Length = 805
Score = 431 bits (1063), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 630
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 631 KAYEWNDN 638
>AY217547-1|AAO25651.1| 805|Homo sapiens angiotensin I converting
enzyme (peptidyl-dipeptidase A) 2 protein.
Length = 805
Score = 431 bits (1063), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 630
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 631 KAYEWNDN 638
>AL110224-1|CAB53682.1| 804|Homo sapiens hypothetical protein
protein.
Length = 804
Score = 431 bits (1063), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 41 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 100
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 101 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 159
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 160 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 219
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 220 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 278
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 279 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 338
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 339 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 397
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 398 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 457
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 458 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 517
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 518 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 571
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 572 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 629
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 630 KAYEWNDN 637
>AF291820-1|AAF99721.1| 805|Homo sapiens ACE-related
carboxypeptidase ACE2 protein.
Length = 805
Score = 431 bits (1063), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 630
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 631 KAYEWNDN 638
>AF241254-1|AAF78220.1| 805|Homo sapiens angiotensin converting
enzyme-like protein protein.
Length = 805
Score = 431 bits (1063), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 630
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 631 KAYEWNDN 638
>AB193260-1|BAD99267.1| 805|Homo sapiens angiotensin-converting
enzyme 2 protein.
Length = 805
Score = 431 bits (1063), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 630
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 631 KAYEWNDN 638
>AB193259-1|BAD99266.1| 805|Homo sapiens angiotensin-converting
enzyme 2 protein.
Length = 805
Score = 431 bits (1063), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 630
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 631 KAYEWNDN 638
>AB046569-1|BAB40370.1| 805|Homo sapiens ACE2 protein.
Length = 805
Score = 431 bits (1062), Expect = e-120
Identities = 226/608 (37%), Positives = 344/608 (56%), Gaps = 23/608 (3%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNALANMLKMGSSKPWPDAMEA 580
+ QFQF ALCQ A +H L CDI S AG L NML++G S+PW A+E
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALEN 572
Query: 581 LTGQREMKADGLLEYFRPLHDWLRAENQRTGEHIGWEPTNMEYCTPSQLSELNVKEPASS 640
+ G + M LL YF PL WL+ +N+ + +GW Y S +++K
Sbjct: 573 VVGAKNMNVRPLLNYFEPLFTWLKDQNKNS--FVGWSTDWSPYADQSIKVRISLKSALGD 630
Query: 641 PATQQSDS 648
A + +D+
Sbjct: 631 RAYEWNDN 638
>AY358714-1|AAQ89076.1| 555|Homo sapiens ACE2 protein.
Length = 555
Score = 379 bits (933), Expect = e-104
Identities = 199/522 (38%), Positives = 300/522 (57%), Gaps = 21/522 (4%)
Query: 53 RASLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYS 112
++SLA W Y +NIT+EN + + S K +MY Q+ Q+ T++ +
Sbjct: 42 QSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQ 101
Query: 113 QLGVAALPDDKFQALMRTVSGMESNYATAKICSYKNESKCDLSLEPEITEIFSTSQDPEE 172
Q G + L +DK + L ++ M + Y+T K+C+ N +C L LEP + EI + S D E
Sbjct: 102 QNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-LLLEPGLNEIMANSLDYNE 160
Query: 173 LKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNGFDNVAEWWQSEYEVPDFE------- 225
AW W + G + + +YV L NE A+ N +++ ++W+ +YEV +
Sbjct: 161 RLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRG 220
Query: 226 ---EQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPAHLLGNMWAQTWNNIE 282
E + +E++KPLY+ LHAYVR +L + Y +S G +PAHLLG+MW + W N+
Sbjct: 221 QLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLPAHLLGDMWGRFWTNLY 279
Query: 283 SFTRPYPDKKEIDVTQAMRDQNYTPMKMFQMSDEFFRSLNLTAMPEKFWKNSIIEKPTD- 341
S T P+ K IDVT AM DQ + ++F+ +++FF S+ L M + FW+NS++ P +
Sbjct: 280 SLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNV 339
Query: 342 REIVCHASAWDFFDGEDFRIKQCTTVDYEYFQTTHHEMGHIQYYLQYRDQPVVFRDGANQ 401
++ VCH +AWD G DFRI CT V + F T HHEMGHIQY + Y QP + R+GAN+
Sbjct: 340 QKAVCHPTAWDLGKG-DFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANE 398
Query: 402 GFHEAVGDTIALSVSSPKHLRRVGLATGD-AEDEQTEINQLYKMGIDKIAFLPFAYTLDL 460
GFHEAVG+ ++LS ++PKHL+ +GL + D ED +TEIN L K + + LPF Y L+
Sbjct: 399 GFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEK 458
Query: 461 FRYGVFRRKTLPEDYNCHYWKLREQLQGVEPPVNRTEDDFDAAAKYHVSANVEYARYYVS 520
+R+ VF+ + + + +W+++ ++ GV PV E D A+ +HVS + + RYY
Sbjct: 459 WRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSDDYSFIRYYTR 518
Query: 521 FIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNAL 562
+ QFQF ALCQ A +H L CDI S AG L
Sbjct: 519 TLYQFQFQEALCQ-AAKHEG-----PLHKCDISNSTEAGQKL 554
>S81361-1|AAD14360.1| 135|Homo sapiens angiotensin I-converting
enzyme protein.
Length = 135
Score = 139 bits (336), Expect = 3e-32
Identities = 60/131 (45%), Positives = 87/131 (66%)
Query: 148 NESKCDLSLEPEITEIFSTSQDPEELKHAWVEWHNAAGATAKKNFTDYVNLYNEAAKLNG 207
N++ SL+P++T I ++S+ L AW WHNAAG K + D+ L NEA K +G
Sbjct: 3 NKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDG 62
Query: 208 FDNVAEWWQSEYEVPDFEEQLAKLWEDVKPLYQQLHAYVRKRLRDKYGDKVVSARGPIPA 267
F + +W+S Y P FE+ L L++ ++PLY LHA+VR+ L +YGD+ ++ RGPIPA
Sbjct: 63 FTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPA 122
Query: 268 HLLGNMWAQTW 278
HLLG+MWAQ+W
Sbjct: 123 HLLGDMWAQSW 133
>AY999974-1|ABA39230.1| 47|Homo sapiens angiotensin I converting
enzyme protein.
Length = 47
Score = 45.2 bits (102), Expect = 7e-04
Identities = 19/46 (41%), Positives = 28/46 (60%)
Query: 437 EINQLYKMGIDKIAFLPFAYTLDLFRYGVFRRKTLPEDYNCHYWKL 482
E+N L + ++KIAF+PF Y +DL R+ VF + YN +W L
Sbjct: 2 EVNFLMHIALEKIAFIPFGYLMDLLRWKVFDGTIWKDIYNQEWWNL 47
>AY999973-1|ABA39229.1| 32|Homo sapiens angiotensin I converting
enzyme protein.
Length = 32
Score = 41.5 bits (93), Expect = 0.009
Identities = 16/32 (50%), Positives = 20/32 (62%)
Query: 272 NMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQ 303
NMWAQTW+NI P+P +D T+AM Q
Sbjct: 1 NMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQ 32
>AY999972-1|ABA39228.1| 32|Homo sapiens angiotensin I converting
enzyme protein.
Length = 32
Score = 41.5 bits (93), Expect = 0.009
Identities = 16/32 (50%), Positives = 20/32 (62%)
Query: 272 NMWAQTWNNIESFTRPYPDKKEIDVTQAMRDQ 303
NMWAQTW+NI P+P +D T+AM Q
Sbjct: 1 NMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQ 32
>DQ457018-1|ABF00475.1| 42|Homo sapiens angiotensin I converting
enzyme protein.
Length = 42
Score = 41.1 bits (92), Expect = 0.012
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 6/47 (12%)
Query: 516 RYYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNAL 562
RY++S ++QFQFH LC+ +G L CDIY S AG L
Sbjct: 1 RYFLSLVLQFQFHETLCKASGHMG------PLHQCDIYNSKIAGKLL 41
>DQ458794-1|ABE96829.1| 41|Homo sapiens angiotensin I converting
enzyme protein.
Length = 41
Score = 36.7 bits (81), Expect = 0.26
Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 6/46 (13%)
Query: 517 YYVSFIIQFQFHRALCQLAGEHAAGDPNKKLVDCDIYQSVAAGNAL 562
Y++S ++ FQFH LC+ +G L CDIY S AG L
Sbjct: 1 YFLSLVLXFQFHETLCKASGHMG------PLHQCDIYNSKIAGKLL 40
>M86868-1|AAA52510.1| 465|Homo sapiens gamma-amino butyric acid
protein.
Length = 465
Score = 31.5 bits (68), Expect = 9.6
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 55 SLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYSQL 114
SLA + + +T+E + I HL LS + AA ++ + G F+ F KYS+L
Sbjct: 388 SLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRL 447
>BC130354-1|AAI30355.1| 465|Homo sapiens gamma-aminobutyric acid
(GABA) receptor, rho 2 protein.
Length = 465
Score = 31.5 bits (68), Expect = 9.6
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 55 SLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYSQL 114
SLA + + +T+E + I HL LS + AA ++ + G F+ F KYS+L
Sbjct: 388 SLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRL 447
>BC130352-1|AAI30353.1| 465|Homo sapiens gamma-aminobutyric acid
(GABA) receptor, rho 2 protein.
Length = 465
Score = 31.5 bits (68), Expect = 9.6
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 55 SLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYSQL 114
SLA + + +T+E + I HL LS + AA ++ + G F+ F KYS+L
Sbjct: 388 SLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRL 447
>AL121833-2|CAC07339.1| 465|Homo sapiens gamma-aminobutyric acid
(GABA) receptor, rho 2 protein.
Length = 465
Score = 31.5 bits (68), Expect = 9.6
Identities = 19/60 (31%), Positives = 30/60 (50%)
Query: 55 SLAEWEYTSNITKENEEKSIQTHLELSRQEKAAWEETKMYGWQDFQDFTLRRMFKKYSQL 114
SLA + + +T+E + I HL LS + AA ++ + G F+ F KYS+L
Sbjct: 388 SLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRL 447
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.317 0.132 0.405
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 96,361,028
Number of Sequences: 224733
Number of extensions: 3996438
Number of successful extensions: 9427
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 9262
Number of HSP's gapped (non-prelim): 34
length of query: 648
length of database: 73,234,838
effective HSP length: 95
effective length of query: 553
effective length of database: 51,885,203
effective search space: 28692517259
effective search space used: 28692517259
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 68 (31.5 bits)
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