Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002462-TA|BGIBMGA002462-PA|IPR013982|AICARFT/IMPCHase
bienzyme, formylation region, IPR002695|AICARFT/IMPCHase bienzyme,
IPR011607|MGS-like
(589 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protei... 805 0.0
UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome sh... 668 0.0
UniRef50_Q0YKD5 Cluster: IMP cyclohydrolase; n=2; Geobacter|Rep:... 358 2e-97
UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 270 9e-71
UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protei... 265 3e-69
UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 261 4e-68
UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 260 6e-68
UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protei... 260 7e-68
UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protei... 258 4e-67
UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 254 5e-66
UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protei... 251 5e-65
UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protei... 249 1e-64
UniRef50_A6G003 Cluster: Bifunctional phosphoribosylaminoimidazo... 248 3e-64
UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protei... 246 1e-63
UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protei... 246 2e-63
UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide... 244 4e-63
UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protei... 244 7e-63
UniRef50_Q8PYG4 Cluster: Formyltransferase phosphoribosylaminoim... 239 1e-61
UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protei... 237 5e-61
UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protei... 226 1e-57
UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protei... 225 3e-57
UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 224 4e-57
UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide... 224 6e-57
UniRef50_Q95QQ5 Cluster: Putative uncharacterized protein; n=2; ... 222 2e-56
UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protei... 218 3e-55
UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protei... 218 4e-55
UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n... 216 1e-54
UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protei... 213 8e-54
UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 213 1e-53
UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protei... 211 4e-53
UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protei... 210 1e-52
UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide... 202 2e-50
UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide... 198 4e-49
UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 196 1e-48
UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio b... 192 2e-47
UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protei... 188 3e-46
UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 188 4e-46
UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrola... 186 1e-45
UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacteri... 180 7e-44
UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protei... 179 2e-43
UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protei... 167 1e-39
UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1; unc... 165 4e-39
UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1; ... 156 1e-36
UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide... 155 2e-36
UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 150 1e-34
UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus Des... 145 3e-33
UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protei... 141 5e-32
UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protei... 137 7e-31
UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 131 4e-29
UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 111 7e-23
UniRef50_Q6PWM1 Cluster: 5-aminoimidazole-4-carboxamide ribonucl... 103 2e-20
UniRef50_A5N885 Cluster: Conserved protein; n=1; Clostridium klu... 95 4e-18
UniRef50_Q9HS43 Cluster: Phosphoribosylaminoimidazole-succinocar... 93 2e-17
UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole gen... 77 2e-12
UniRef50_A0B9A9 Cluster: Phosphoribosylaminoimidazolecarboxamide... 73 2e-11
UniRef50_Q46480 Cluster: Bifunctional purine biosynthesis protei... 68 6e-10
UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 65 4e-09
UniRef50_Q6AMF5 Cluster: Related to bifunctional purine biosynth... 63 2e-08
UniRef50_O28464 Cluster: Inosine monophosphate cyclohydrolase; n... 59 3e-07
UniRef50_A6PRZ4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 58 9e-07
UniRef50_A6DLC7 Cluster: IMP cyclohydrolase; n=1; Lentisphaera a... 54 8e-06
UniRef50_Q5KN32 Cluster: IMP cyclohydrolase, putative; n=1; Filo... 54 1e-05
UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 52 4e-05
UniRef50_Q5FJY6 Cluster: Carbamoyl-phosphate synthase large subu... 42 0.035
UniRef50_Q4RQF9 Cluster: Chromosome 17 SCAF15006, whole genome s... 40 0.14
UniRef50_Q73FN1 Cluster: Carbamoyl-phosphate synthase, large sub... 39 0.32
UniRef50_P77886 Cluster: Carbamoyl-phosphate synthase pyrimidine... 39 0.32
UniRef50_A6CPS0 Cluster: Carbamoyl-phosphate synthase large subu... 39 0.43
UniRef50_O50236 Cluster: Carbamoyl-phosphate synthase large chai... 38 0.57
UniRef50_UPI0000DB7FED Cluster: PREDICTED: similar to Carbamoyl-... 38 0.75
UniRef50_Q8XZ83 Cluster: Carbamoyl-phosphate synthase large chai... 38 0.99
UniRef50_A6NS15 Cluster: Putative uncharacterized protein; n=1; ... 37 1.7
UniRef50_A6DMV9 Cluster: Putative uncharacterized protein; n=1; ... 36 2.3
UniRef50_UPI0000382898 Cluster: COG0138: AICAR transformylase/IM... 36 4.0
UniRef50_A4BV92 Cluster: Glutamate dehydrogenase; n=3; cellular ... 36 4.0
UniRef50_Q82GJ7 Cluster: Putative uncharacterized protein; n=1; ... 35 5.3
UniRef50_Q0F2Y5 Cluster: ATP phosphoribosyltransferase regulator... 34 9.2
UniRef50_P53127 Cluster: SANT domain-containing protein 2; n=2; ... 34 9.2
>UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protein
PURH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=105; cellular organisms|Rep:
Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Homo sapiens (Human)
Length = 592
Score = 805 bits (1992), Expect = 0.0
Identities = 389/587 (66%), Positives = 463/587 (78%), Gaps = 4/587 (0%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL SVSDKTGL+ A++L+ GL L+ASGGTA ALR+AGL V+DVS++T PEMLGGRVK
Sbjct: 7 ALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVK 66
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHPAVHAGILAR D DM R + +I VV CNLYPFV+TV+ P VTV +AVE IDI
Sbjct: 67 TLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDI 126
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GGVTLLRAAAKNH RVTVVC+P DY V E++ ++ T+L TR++LALKAFTHT+ YD
Sbjct: 127 GGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYD 186
Query: 186 LAISDYFRKQYSPGQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPGFINLCDALNA 245
AISDYFRKQYS G +Q+ LRYGMNPHQ PAQ++T + LPIT LNGAPGFINLCDALNA
Sbjct: 187 EAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNA 246
Query: 246 WQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAG---ELSXXXXXXXXX 302
WQLVKELKEAL +PAAASFKHVSPAGAAVG+PL+++EA VCMV L+
Sbjct: 247 WQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARA 306
Query: 303 XXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLK 362
MSSFGDFVALSD CDV TA IISREVSDG+IAPGY EAL +LSKKK GNYCVL+
Sbjct: 307 RGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQ 366
Query: 363 IDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVATIALK 422
+D +Y+P E +T+FGL L QKRN+ + LF NVVT KDLP +A+RDLIVATIA+K
Sbjct: 367 MDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVK 426
Query: 423 YTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAALWWLRRHPSVLAMRFRQGVTRAV 482
YTQSNSVC+A++GQVIGIGAGQQSRIHCTRLAG KA WWLR HP VL+M+F+ GV RA
Sbjct: 427 YTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAE 486
Query: 483 QANAIDNYVNGTVGSDLPLEQWDTLFEGKPPALFTDSQREEWIKKMDKVALASDAFFPFR 542
+NAID YV GT+G D L +W LFE + P L T+++++EW++K+ +V+++SDAFFPFR
Sbjct: 487 ISNAIDQYVTGTIGEDEDLIKWKALFE-EVPELLTEAEKKEWVEKLTEVSISSDAFFPFR 545
Query: 543 DNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
DN+DRA + GV YI +PSGS D+ VIEAC+E I LAHTNLRLFHH
Sbjct: 546 DNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH 592
>UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 628
Score = 668 bits (1651), Expect = 0.0
Identities = 352/607 (57%), Positives = 422/607 (69%), Gaps = 39/607 (6%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSVSDKTGL+ AK L + GL L+ASGGTA LR+AG V+DVS++T PEMLGGRVK
Sbjct: 1 ALLSVSDKTGLVQFAKRLVDVGLSLVASGGTAKTLRDAGWAVRDVSELTGHPEMLGGRVK 60
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHPAVH GILAR S +D DM++ Y +I VVVCNLYPFV+TVS P VTV DAVE IDI
Sbjct: 61 TLHPAVHGGILARKSPADTADMEKLGYSLIRVVVCNLYPFVKTVSNPSVTVEDAVEQIDI 120
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GGVTLLRAAAKNH RVTVVCDPADY V +E++ + T +R RL+ T+ D
Sbjct: 121 GGVTLLRAAAKNHARVTVVCDPADYPRVAEEMEGSGSRDTP--SRTRLSTTRPYRTTSGD 178
Query: 186 LAISDYFRKQYSPGQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPGFINLCDALNA 245
+ + YGMNPHQ PAQ++T R +LP+ +NG+PGFINLCDALNA
Sbjct: 179 SSAVAF---------PSCLCVYGMNPHQAPAQLYTLRPALPLRVVNGSPGFINLCDALNA 229
Query: 246 WQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMV---AGELSXXXXXXXXX 302
WQLV+EL +AL + AA SFKHVSPAGAAVG+PL++EEA VCMV +L+
Sbjct: 230 WQLVRELSKALGVAAATSFKHVSPAGAAVGVPLSEEEARVCMVHDMMKDLTPLATAYARA 289
Query: 303 XXXXXMSSFGDFVALSDPCDVSTATIISRE----------------------VSDGVIAP 340
MSSFGDF+ALSD CDV TA IISRE VSDG+IAP
Sbjct: 290 RGSDRMSSFGDFIALSDVCDVPTAKIISREVNRGASGVSSPASCGNNRIFSQVSDGIIAP 349
Query: 341 GYSPEALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVV 400
GY EALK+LSKKK GNYCVL++DP YEP E + +FGL L+QKRN I E F NVV
Sbjct: 350 GYDEEALKILSKKKNGNYCVLQMDPEYEPDETEVRVLFGLYLKQKRNGGIINKEFFSNVV 409
Query: 401 TTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAAL 460
+K L +A+RDL VATIALKYTQSNSVC+A+DGQVIGIGAGQQSRIHCTRLAG KA
Sbjct: 410 -SKGSLSEDALRDLTVATIALKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKADN 468
Query: 461 WWLRRHPSVLAMRFRQGVTRAVQANAIDNYVNGTVGSDLPLEQWDTLFEGKPPALFTDSQ 520
WWLR HP VL M+FR GV RA ANA+D YV+ T+G L W ++F+ + P L + ++
Sbjct: 469 WWLRHHPRVLNMKFRPGVKRAEMANAVDQYVSDTIGEGPDLAVWKSMFD-EVPELLSAAE 527
Query: 521 REEWIKKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIAL- 579
++ WI + V ++SDAFFPFRDNIDRA + GV+YI +P+GS DQ VI+ACNE I L
Sbjct: 528 KKNWIGSLQSVVVSSDAFFPFRDNIDRAKRSGVQYIAAPAGSAADQVVIDACNEQGITLV 587
Query: 580 AHTNLRL 586
AH + L
Sbjct: 588 AHKSTPL 594
>UniRef50_Q0YKD5 Cluster: IMP cyclohydrolase; n=2; Geobacter|Rep:
IMP cyclohydrolase - Geobacter sp. FRC-32
Length = 388
Score = 358 bits (881), Expect = 2e-97
Identities = 183/389 (47%), Positives = 245/389 (62%), Gaps = 3/389 (0%)
Query: 202 QLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPGFINLCDALNAWQLVKELKEALSLPAA 261
++ L+YG N HQ PA + +S LNG P +IN+ DAL AWQL +ELK A S P A
Sbjct: 2 EIKLKYGCNSHQTPANLIIPENS-GFQVLNGTPSYINILDALGAWQLARELKIATSKPGA 60
Query: 262 ASFKHVSPAGAAVGLPLTDEEAAVCMVA-GELSXXXXXXXXXXXXXXMSSFGDFVALSDP 320
ASFKH SPAGAAV L D A ++ +LS M SFGD A+SD
Sbjct: 61 ASFKHTSPAGAAVAGALPDSYCASQFLSQSDLSPVATAYVRARGGDRMCSFGDVAAVSDI 120
Query: 321 CDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGL 380
DVS A ++ EVSD +IAPG+ P AL++L KK G Y +L+IDP YEP+ +EQ+ +FG
Sbjct: 121 VDVSLANVLKSEVSDLIIAPGFEPAALEILKAKKQGTYLILQIDPDYEPAEIEQREVFGF 180
Query: 381 TLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGI 440
L+QKRN A ++A LF+N VT K + + LIVATIALK+TQSNSVC A +GQVIG+
Sbjct: 181 GLQQKRNTAPVSAALFQNSVTIGKSVSPDITETLIVATIALKFTQSNSVCLAYEGQVIGM 240
Query: 441 GAGQQSRIHCTRLAGGKAALWWLRRHPSVLAMRFRQGVTRAVQANAIDNYVNGTVGSDLP 500
GAGQQSR+HCTRLA KA W L++HP L + FR+G+ + +AN +D ++ S+
Sbjct: 241 GAGQQSRVHCTRLACDKADKWLLQQHPKTLNLAFREGLKKPDKANIVDQFLLWDQLSEAE 300
Query: 501 LEQWDTLFEGKPPALFTDSQREEWIKKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPS 560
+Q T F K P + +R EW+K+ + L+SDA+ PFRDNIDRA + V+++
Sbjct: 301 KKQMRTGFM-KEPDPISAQERLEWVKQFPGICLSSDAYIPFRDNIDRANRSNVQFVAHAG 359
Query: 561 GSNNDQEVIEACNEHKIALAHTNLRLFHH 589
S D+EV EA ++ + + HT LRLF H
Sbjct: 360 SSLRDEEVTEAAKQYDMTMLHTGLRLFLH 388
>UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Azoarcus sp.
(strain BH72)
Length = 527
Score = 270 bits (661), Expect = 9e-71
Identities = 199/513 (38%), Positives = 271/513 (52%), Gaps = 59/513 (11%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDK G+L A+ L+ G++L+++GGTA LR+AGL V DVS+ T PEML GRVK
Sbjct: 6 ALISVSDKRGVLDFARELAGLGIKLLSTGGTAALLRDAGLPVTDVSEHTGFPEMLDGRVK 65
Query: 66 TLHPAVHAGILARLSDSDQED-MKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP VH GILAR ++ D + I +VV NLYPF TV++PD T+ DA+ENID
Sbjct: 66 TLHPKVHGGILARRDLAEHMDTIAAHDISRIDLVVVNLYPFQATVARPDCTLEDAIENID 125
Query: 125 IGGVTLLRAAAKNHDR----VTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTH 180
IGG T++RAAAKNH V +V DP DY +V E+K N + + TR LA+KAFTH
Sbjct: 126 IGGPTMVRAAAKNHGTEAGGVGIVTDPEDYAGIVAELKANA-NTLSYKTRFALAVKAFTH 184
Query: 181 TSDYDLAISDYF-----------RKQYSPGQAQL------TLRYGMNPHQKPA---QVFT 220
T+ YD AIS++ KQ P + QL LRYG NPHQ A +
Sbjct: 185 TARYDSAISNHLTALVTNDAGDVSKQAYPERFQLAFDKVQNLRYGENPHQSAAFYKEPGA 244
Query: 221 TRDSL-PITTLNGAP-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPL 278
+ T L G + N+ DA AW+ VK A A KH +P G A+G
Sbjct: 245 AEGGIASYTQLQGKELSYNNIADADAAWECVK----AFDTGACVIVKHANPCGVALG--A 298
Query: 279 TDEEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVI 338
T EA S+FG +A + D + A +S + + +I
Sbjct: 299 TPLEA---------------YKKAFSTDPTSAFGGIIAFNGEVDRAAAEAVSAQFLEVLI 343
Query: 339 APGYSPEALKLLSKKKGGNYCVLKIDPTYEPS-LMEQKTIFGLTLEQKRNDAKITAELFK 397
AP Y+ +AL+LL K+ N VL P +PS ++ K + G L Q ++A+I +L
Sbjct: 344 APSYTADALELLRAKQ--NVRVLTC-PLGKPSGALDYKRVGGGLLVQSADEARI--QLAD 398
Query: 398 NVVTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGK 457
V TK+ +RD++ A KY +SN++ + +DG IG+GAGQ SR+ R+A K
Sbjct: 399 LKVVTKRAPSDTELRDMLFAWRVAKYVKSNAIVYCKDGMTIGVGAGQMSRVDSARIAKIK 458
Query: 458 AALWWLRRHPSVLA----MRFRQGVTRAVQANA 486
A L V+A FR G+ QA A
Sbjct: 459 AENAGLAIPGCVVASDAFFPFRDGLDVLAQAGA 491
Score = 59.7 bits (138), Expect = 2e-07
Identities = 28/57 (49%), Positives = 33/57 (57%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASDAFFPFRD +D Q G + P GS D EVI A +E IA+ T R F H
Sbjct: 471 VASDAFFPFRDGLDVLAQAGATAVIQPGGSMRDAEVIAAADEQNIAMVFTGFRHFRH 527
>UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=59; Proteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Yersinia pestis
Length = 529
Score = 265 bits (649), Expect = 3e-69
Identities = 193/506 (38%), Positives = 269/506 (53%), Gaps = 57/506 (11%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSVSDK G++ A++LS+ G++L+++GGTA L +AGL V +VSD T PEM+ GRVK
Sbjct: 10 ALLSVSDKAGIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMMDGRVK 69
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHP VH GIL R D M + + I +VV NLYPF QTV++PD ++ DAVENIDI
Sbjct: 70 TLHPKVHGGILGR-RGQDDGIMAQHGIQPIDIVVVNLYPFAQTVARPDCSLEDAVENIDI 128
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GG T++R+AAKNH V +V +DY A++ E+ +N T TR LA+KAF HT+ YD
Sbjct: 129 GGPTMVRSAAKNHKDVAIVVKSSDYPAIITEL-DNNDGSLTYPTRFNLAIKAFEHTAAYD 187
Query: 186 LAISDYFRKQYSP---------GQAQLTL----------RYGMNPHQKPAQVF--TTRDS 224
I++YF P G TL RYG N HQ+ A +++
Sbjct: 188 SMIANYFGTLVPPYHGDTEQPSGHFPRTLNLNYIKKQDMRYGENSHQQAAFYIEEDVKEA 247
Query: 225 LPITT--LNG-APGFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDE 281
T L G A + N+ D A + VKE E PA KH +P G A+G D
Sbjct: 248 SVATAQQLQGKALSYNNIADTDAALECVKEFSE----PACVIVKHANPCGVAIG----DS 299
Query: 282 EAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTAT-IISREVSDGVIAP 340
A A + S+FG +A + D +TA+ IISR+ + +IAP
Sbjct: 300 ILAAYERAYQTDPT-------------SAFGGIIAFNRELDAATASAIISRQFVEVIIAP 346
Query: 341 GYSPEALKLLSKKKGGNYCVLKIDPTYEPSL-MEQKTIFGLTLEQKRNDAKITAELFKNV 399
S +AL LL+ K+ N VL S ++ K + G L Q+R+ +TA +
Sbjct: 347 TVSSDALALLAAKQ--NVRVLTCGQWQARSAGLDFKRVNGGLLVQERDLGMVTAADLR-- 402
Query: 400 VTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAA 459
V +K+ +RD + K+ +SN++ +ARD IGIGAGQ SR++ ++AG KAA
Sbjct: 403 VVSKRQPTEQELRDALFCWKVAKFVKSNAIVYARDNMTIGIGAGQMSRVYSAKIAGIKAA 462
Query: 460 LWWLRRHPSVLA----MRFRQGVTRA 481
L S +A FR G+ A
Sbjct: 463 DEGLEVAGSAMASDAFFPFRDGIDAA 488
Score = 67.7 bits (158), Expect = 8e-10
Identities = 31/58 (53%), Positives = 38/58 (65%)
Query: 532 ALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
A+ASDAFFPFRD ID A G+ + P GS D EVI A +EH IA+ T++R F H
Sbjct: 472 AMASDAFFPFRDGIDAAAAVGITCVIQPGGSIRDDEVIAAADEHSIAMIFTDMRHFRH 529
>UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase; n=4;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase - Bradyrhizobium
sp. (strain BTAi1 / ATCC BAA-1182)
Length = 530
Score = 261 bits (639), Expect = 4e-68
Identities = 175/469 (37%), Positives = 256/469 (54%), Gaps = 40/469 (8%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSVSDKTGL+ A+SL+ G++LI++GGTA A+ +AGL V+DVSD+T PEM+ GRVK
Sbjct: 11 ALLSVSDKTGLVEFARSLAARGIELISTGGTAKAIADAGLKVKDVSDLTGFPEMMDGRVK 70
Query: 66 TLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP VH G+LA R +D E MK I ++V NLYPF TV + +D +ENID
Sbjct: 71 TLHPKVHGGLLAIRGNDEHAEAMKTHGIAPIDLLVVNLYPFEATVER-SAPFSDCIENID 129
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG ++RAA+KNH+ V VV D DYDAV++++ ++ TTL R+RLA KA+ T+ Y
Sbjct: 130 IGGPAMIRAASKNHEDVAVVVDVNDYDAVLEDLARHE-GSTTLLLRRRLAAKAYARTAAY 188
Query: 185 DLAISDYFR---KQYSP------GQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPG 235
D AIS++F + +P G+ +LRYG NPHQ A + T G
Sbjct: 189 DAAISNWFAATIQNDAPDYRAFGGRLIQSLRYGENPHQHAAFYALPGRRPGVATARQVQG 248
Query: 236 ----FINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTD--EEAAVCMVA 289
+ N+ D A++ + E A + A KH +P G A G L ++A C
Sbjct: 249 KELSYNNINDTDAAYECIAEFDPART-AACVIVKHANPCGVAEGPDLITAYQKALAC--- 304
Query: 290 GELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKL 349
S+FG +A++ D +TA I+ ++ +IAP + EA+ +
Sbjct: 305 ----------------DSTSAFGGIIAMNRKLDAATARAITGIFTEVIIAPDATEEAIAV 348
Query: 350 LSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSN 409
++ +K + P + + KT+ G L Q R++A + K V TK+
Sbjct: 349 IAARKTLRLLLAGALPDPREAGLTAKTVAGGLLVQSRDNAVVDDMTLK--VVTKRAPTEA 406
Query: 410 AVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
+RDL A K+ +SN++ +A+D +GIGAGQ SR+ R+A KA
Sbjct: 407 ELRDLRFAFRVAKHVKSNTIIYAKDSATVGIGAGQMSRVDSARIAARKA 455
Score = 56.8 bits (131), Expect = 2e-06
Identities = 26/57 (45%), Positives = 35/57 (61%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASDAFFPF D + ++ G + P GS D EVI+A +EH IA+ T +R F H
Sbjct: 474 VASDAFFPFADGMLACIEAGATAVIQPGGSVRDDEVIKAADEHGIAMVLTGVRHFRH 530
>UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Treponema
denticola
Length = 533
Score = 260 bits (638), Expect = 6e-68
Identities = 179/477 (37%), Positives = 254/477 (53%), Gaps = 40/477 (8%)
Query: 4 GTALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGR 63
G L SVSDKTGL A L G IASGGTA L+ AG+ V++VS+ T +PE+LGGR
Sbjct: 2 GLVLASVSDKTGLKDFAFRLKAAGYDFIASGGTAKTLQEAGIKVKEVSEYTSSPEILGGR 61
Query: 64 VKTLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENI 123
VKTLHP +H GILAR + D+ ++K + I +V+ NLYPF +T+S PD T +D +ENI
Sbjct: 62 VKTLHPMIHGGILARDTKEDRAELKALGFSGIDIVIANLYPFEKTISSPDSTESDCIENI 121
Query: 124 DIGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSD 183
DIGGV LLRAAAKN+ RVTV+CDPADYD V EI+ K + +L R+RLA+KAF +
Sbjct: 122 DIGGVALLRAAAKNYSRVTVICDPADYDEVSSEIE--KTGEISLSLRKRLAIKAFDLCTR 179
Query: 184 YDLAISDYFR--KQYSPGQAQLT-----------LRYGMNPHQKPAQVFTTRDSL-PI-- 227
YD AI+ + + S G + T LRYG NPHQK A ++T P+
Sbjct: 180 YDAAITSWLSGLSRLSGGIEEKTSLTLCAYPGQDLRYGENPHQK-AWLYTNEPKAGPLGG 238
Query: 228 TTLNG-APGFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVC 286
L G A + N+ DA AW+ V + PAA KH++P G A + +E A
Sbjct: 239 KVLQGKALSYNNILDADAAWRAV----SMFTKPAAVVVKHLTPCGLA---EINEEPAKSS 291
Query: 287 MVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEA 346
+ S +S+FG +AL+ P D ++ + + +IAP ++ EA
Sbjct: 292 SSSLPNSEVSLALRAAIDCDPVSAFGSIIALNRPFDKASVEALGALFVECIIAPLFTEEA 351
Query: 347 LKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDL 406
+LLS KK N +++ E E K++ G L+Q+++ +K+ K +
Sbjct: 352 KELLSGKK--NLRLIEAPILQEKEPYEYKSVLGGFLKQEKDLGDPEGTEYKDAAERKAEP 409
Query: 407 PSNAVRDLIVATIALKYTQSNSVCFARDGQV---------IGIGAGQQSRIHCTRLA 454
A+ L A A +SN++ A + +GIG GQ +R+ R A
Sbjct: 410 FERAL--LQFAMKACTMVKSNAILLAAPIDLSNPQKGFCSVGIGCGQPNRVDAARQA 464
Score = 59.7 bits (138), Expect = 2e-07
Identities = 27/64 (42%), Positives = 39/64 (60%)
Query: 526 KKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLR 585
+++ LASDAFFPF D I+ A + G++ + P GS D IE CN+H +A+ T +R
Sbjct: 470 ERVKNSVLASDAFFPFPDTIEEAAKAGIKAVIQPGGSIRDYLSIEECNKHGMAMLITGVR 529
Query: 586 LFHH 589
F H
Sbjct: 530 HFKH 533
>UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=214; cellular organisms|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Xylella fastidiosa
Length = 527
Score = 260 bits (637), Expect = 7e-68
Identities = 188/490 (38%), Positives = 261/490 (53%), Gaps = 52/490 (10%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSVSDKTGL+ LA++L ++L+++GGTAT +R AGL VQDV+D+T PEM+ GRVK
Sbjct: 11 ALLSVSDKTGLVELARALLAYNIELLSTGGTATIIREAGLPVQDVADLTGFPEMMDGRVK 70
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHP VH G+L R + D M + I +++ NLYPF Q +K D T+ADAV+ IDI
Sbjct: 71 TLHPMVHGGLLGR-AGIDDAVMAKHGIAPIDLLILNLYPFEQITAKKDCTLADAVDTIDI 129
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GG +LR+AAKN RV V P Y ++ E++ + H Q + R LA+ AF H + YD
Sbjct: 130 GGPAMLRSAAKNFARVAVATSPDQYPDLLAELQAH-HGQLSAEKRFALAVAAFNHVAQYD 188
Query: 186 LAISDYFR-----------KQYSPGQAQLT------LRYGMNPHQKPA---QVFTTRDSL 225
AIS+Y + P Q T LRYG NPHQ A V +L
Sbjct: 189 AAISNYLSSVSDMHTTLPLRHEFPAQLNNTFVKMTELRYGENPHQTGAFYRDVHPQPGTL 248
Query: 226 P-ITTLNGAP-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEA 283
L G + NL DA AW+ V++ + PA KH +P G AVG +D
Sbjct: 249 ATFQQLQGKTLSYNNLVDADAAWECVRQFEA----PACVIVKHANPCGVAVGKACSD--- 301
Query: 284 AVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVST-ATIISREVSDGVIAPGY 342
S+FG +A++ DV+T +I+ R+ + +IAP Y
Sbjct: 302 --------------AYEEAYATDPTSAFGGIIAVNRMLDVATMQSILDRQFVEVLIAPDY 347
Query: 343 SPEALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTT 402
+AL +KK N VL+I T + + K I L Q + I ++ K VVT
Sbjct: 348 DADALAYATKK--ANVRVLRIPSTGVMNRYDFKRIGSGLLVQSTDSLNIHSDALK-VVT- 403
Query: 403 KKDLPSNA-VRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAALW 461
+ P++A RDL+ A KY +SN++ +A+D + IGIGAGQ SR++ R+AG KAA
Sbjct: 404 -QLAPTDAQQRDLLFAWHVAKYVKSNAIVYAKDNRTIGIGAGQMSRVYSARIAGIKAADA 462
Query: 462 WLRRHPSVLA 471
L SV+A
Sbjct: 463 HLAVTGSVMA 472
Score = 67.3 bits (157), Expect = 1e-09
Identities = 30/57 (52%), Positives = 38/57 (66%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASDAFFPFRD+ID A G++ + P GS D EVI A +EH IA+ T +R F H
Sbjct: 471 MASDAFFPFRDSIDAAAAAGIKAVIQPGGSMRDNEVIAAADEHGIAMVFTGIRHFRH 527
>UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=34; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Oceanobacillus iheyensis
Length = 510
Score = 258 bits (631), Expect = 4e-67
Identities = 171/468 (36%), Positives = 250/468 (53%), Gaps = 44/468 (9%)
Query: 3 SGTALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGG 62
S AL+SVSDKT ++ AK L E G +++++GGT ++ AG+ V V ++T PEML G
Sbjct: 2 SKRALISVSDKTNIIEFAKGLKESGFEILSTGGTLRSIAEAGIDVTPVDEVTGFPEMLDG 61
Query: 63 RVKTLHPAVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVE 121
RVKTLHP +H G+L + S+ + M+ I +V NLYPF +TV KPDV+ D +E
Sbjct: 62 RVKTLHPMIHGGLLGKRSNHEHLSQMEEHGIRSIDLVAVNLYPFKETVQKPDVSHQDIIE 121
Query: 122 NIDIGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHT 181
NIDIGG ++LR+AAKN + V VV P DY+ V+ I T RQ+LA K F HT
Sbjct: 122 NIDIGGPSMLRSAAKNFEDVLVVTGPTDYNRVLAAITS---ETDTYEFRQQLAAKVFRHT 178
Query: 182 SDYDLAISDYFRKQYS---PGQAQLT------LRYGMNPHQKPA---QVFTTRDSLPIT- 228
+ YD I++YF Q P +T LRYG NPHQ+ A + +R +L
Sbjct: 179 ASYDAMIANYFLSQTEEQYPESYTVTYEKVQDLRYGENPHQQAAFYKEPIQSRPTLATAK 238
Query: 229 TLNGAP-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCM 287
L+G + N+ D A ++VKE E PAA + KH++P G +G
Sbjct: 239 QLHGKELSYNNIQDTNAAIEIVKEFAE----PAAVAVKHMNPCGIGIG------------ 282
Query: 288 VAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEAL 347
S FG VA + P D +TA +S+ + V+AP + +AL
Sbjct: 283 -----ESISTAFERAYQADPTSIFGGIVACNRPVDAATAEQLSQIFLEIVVAPSFESQAL 337
Query: 348 KLLSKKKGGNYCVLKIDPTYEPSLMEQ-KTIFGLTLEQKRNDAKITAELFKNVVTTKKDL 406
++L++KK N +L++D T + + T+ G L Q DAK +E VVT K+
Sbjct: 338 EILTQKK--NIRLLELDVTSDNKQSNRLTTVDGGALIQ-AYDAKEVSEADLEVVTNKQP- 393
Query: 407 PSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
+ D++ A A+K+ +SN++ A+D Q IG+GAGQ +RI +A
Sbjct: 394 TEQEINDMLFAWKAVKHVKSNAIVLAKDSQTIGVGAGQMNRIGAAEIA 441
Score = 62.9 bits (146), Expect = 2e-08
Identities = 26/63 (41%), Positives = 39/63 (61%)
Query: 527 KMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRL 586
K + LASDAFFP D ++ A + G++ I P GS DQ+ ++ CN+ IA+ +T +R
Sbjct: 448 KSEGAVLASDAFFPMPDTVEAAAKAGIKAIIQPGGSKRDQDSVDVCNQFGIAMVYTKVRH 507
Query: 587 FHH 589
F H
Sbjct: 508 FKH 510
>UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=5; Coxiella
burnetii|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Coxiella burnetii
Length = 526
Score = 254 bits (622), Expect = 5e-66
Identities = 179/476 (37%), Positives = 254/476 (53%), Gaps = 45/476 (9%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+S +DK GL+ L CG+++IA+GGTA L+ L V DV T PE++ GRVK
Sbjct: 14 ALISTADKIGLIEFISQLVTCGVEIIATGGTAELLKQHQLPVIDVFTYTGFPEIMDGRVK 73
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHP +HAG+LAR D++ + + + I ++V NLYPFVQTVS + ++ AVE IDI
Sbjct: 74 TLHPKIHAGLLARRG-IDEKTLDQHAIKPIDLLVVNLYPFVQTVSASNCSLEKAVEQIDI 132
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GG ++LRAAAKN VTVV DP DY +++EIK + H TTL TR+RLA K F H S YD
Sbjct: 133 GGPSMLRAAAKNFAAVTVVVDPEDYSRILEEIKTH-HGSTTLSTRKRLAQKTFEHLSYYD 191
Query: 186 LAISDYFRKQY----------SPGQAQLTLRYGMNPHQKPAQVF----TTRDSLPITTLN 231
I+ Y ++ S + ++ LRYG NPHQ A + L
Sbjct: 192 AHIATYLAEKEGATTLPARLPSIFKKKIDLRYGENPHQTAALYSIDPPLSHSLAEAQLLQ 251
Query: 232 GAP-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAG 290
G P F NL D+ A++ V E +LS PA KH +PAGAA A + A
Sbjct: 252 GKPLSFNNLLDSDCAYRCVYE--GSLSEPACVIVKHATPAGAA--------RAQTQLAAY 301
Query: 291 ELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTA-TIISREVSDGVIAPGYSPEALKL 349
E +S+FG VA + P + TA I+S++ + +IAP + E L+L
Sbjct: 302 E---------KAYATDPLSAFGGIVAFNAPLEAVTAEKILSQQFVEVIIAPDFPAETLRL 352
Query: 350 LSKKKGGNYCVLKIDPTYEPSLMEQ-KTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPS 408
L K N VL+ P + +I G L Q+ + K + E F V T++ +
Sbjct: 353 LQTKP--NLRVLRGQPLDSSQITYSFHSITGGVLCQEADATKFSDETF--TVVTRRQPTA 408
Query: 409 NAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA---GGKAALW 461
+DL A +KY +SN++ +A+D +GIG+GQ SR+ ++A +A LW
Sbjct: 409 KEQQDLYFAWQIVKYVKSNAIVYAKDHATLGIGSGQTSRVFAAKIAILKAEEAGLW 464
Score = 60.5 bits (140), Expect = 1e-07
Identities = 43/129 (33%), Positives = 65/129 (50%), Gaps = 8/129 (6%)
Query: 464 RRHPSVLAMR---FRQGVTRAVQANAIDNYVNGTVGSDLPLEQWDTLFEGKPPALFTDSQ 520
RR P+ + F + + V++NAI Y + Q +F K A+ +
Sbjct: 403 RRQPTAKEQQDLYFAWQIVKYVKSNAIV-YAKDHATLGIGSGQTSRVFAAKI-AILKAEE 460
Query: 521 REEWIKKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALA 580
W+ D V +ASDAFFPF D+I+ A + G+ + P GS D+EVI+A NE +A+
Sbjct: 461 AGLWLT--DAV-MASDAFFPFSDSIEIAAKAGITAVIQPGGSKRDEEVIKAANEAGMAML 517
Query: 581 HTNLRLFHH 589
T+ R F H
Sbjct: 518 FTHQRHFRH 526
>UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=88; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Haemophilus influenzae
Length = 532
Score = 251 bits (614), Expect = 5e-65
Identities = 176/483 (36%), Positives = 255/483 (52%), Gaps = 57/483 (11%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSVSDKTG++ A+ L + G++L+++GGTA L L V +VSD T PEM+ GRVK
Sbjct: 9 ALLSVSDKTGIVEFAQGLVKRGVKLLSTGGTAKLLAQNALPVIEVSDYTGFPEMMDGRVK 68
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHP VH GIL R +D M++ E I +VV NLYPF TV+KPD T+ADAVENIDI
Sbjct: 69 TLHPKVHGGILGRRG-TDDAIMQQHGIEGIDMVVVNLYPFAATVAKPDCTLADAVENIDI 127
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GG T++R+AAKNH V +V + D++A++ E+ +++ + T TR LA+KAF HT+ YD
Sbjct: 128 GGPTMVRSAAKNHKDVAIVVNNHDFNAILAEMDQHQ-NSLTFETRFDLAIKAFEHTAQYD 186
Query: 186 LAISDYFRKQYSP-------------GQAQLTL----------RYGMNPHQKPA-QVFTT 221
I++YF + P GQ TL RYG N HQ A V
Sbjct: 187 SMIANYFGQLVKPYHIAEEEEANAKCGQFPRTLNLNFVRKQAMRYGENSHQNAAFYVDLN 246
Query: 222 RDSLPITTLNGAPG----FINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLP 277
+ T N G + N+ D A + VKE + PA KH +P G A+G
Sbjct: 247 VKEASVATANQLQGKALSYNNIADTDAALECVKEFDD----PACVIVKHANPCGVALGKD 302
Query: 278 LTDEEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTAT-IISREVSDG 336
+ D S+FG +A + D TA I+ R+ +
Sbjct: 303 ILD-----------------AYNRAYQTDPTSAFGGIIAFNRELDEKTANEIVERQFVEV 345
Query: 337 VIAPGYSPEALKLLSKKKGGNYCVLKI-DPTYEPSLMEQKTIFGLTLEQKRNDAKITAEL 395
+IAP S EA +++ +KK N +L+ + T ++ K + G L Q + + +
Sbjct: 346 IIAPKVSAEAQEVMKRKK--NVRLLECGEWTSRSERLDFKRVNGGLLVQDADLGMVGVDD 403
Query: 396 FKNVVTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAG 455
K V +K+ ++DL+ K+ +SN++ +A+D Q IGIGAGQ SR++ ++AG
Sbjct: 404 LK--VVSKRQPTEQELKDLLFCWKVAKFVKSNAIVYAKDNQTIGIGAGQMSRVYSAKIAG 461
Query: 456 GKA 458
KA
Sbjct: 462 IKA 464
Score = 67.7 bits (158), Expect = 8e-10
Identities = 29/57 (50%), Positives = 39/57 (68%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASDAFFPFRD ID A + G++ + P GS DQEVI+A +EH + + T +R F H
Sbjct: 476 MASDAFFPFRDGIDAAAKVGIQCVIHPGGSMRDQEVIDAADEHNMVMVLTGMRHFRH 532
>UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=57; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Streptococcus suis
Length = 515
Score = 249 bits (610), Expect = 1e-64
Identities = 173/467 (37%), Positives = 250/467 (53%), Gaps = 43/467 (9%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDK G++ A+ L++ G ++I++GGT AL AG+T + D+T PEM+ GRVK
Sbjct: 5 ALISVSDKNGIVEFAQELTKFGWEIISTGGTKVALDQAGVTTIAIDDVTGFPEMMDGRVK 64
Query: 66 TLHPAVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +H G+LAR DS + + +I +VV NLYPF +T+ +PDVT AVENID
Sbjct: 65 TLHPKIHGGLLARRDLDSHLQAANDHEIGLIDLVVVNLYPFKETILRPDVTYDLAVENID 124
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG ++LR+AAKNH VTVV DPADY V+ EI E +T+ TRQRLA K F HT+ Y
Sbjct: 125 IGGPSMLRSAAKNHASVTVVVDPADYPTVLGEIAE--QGETSYATRQRLAAKVFRHTAAY 182
Query: 185 DLAISDYFRKQY---SPGQAQLT------LRYGMNPHQKP---AQVFTTRDSLPIT-TLN 231
D I+DYF KQ P + +T +RYG NP Q T S+ LN
Sbjct: 183 DALIADYFTKQVGEDKPEKLTITYDLNQPMRYGENPQQNADFYQNALPTAYSIAAAKQLN 242
Query: 232 GAP-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAG 290
G F N+ DA A +++++ K+ P + KH++P G +G T E+A
Sbjct: 243 GKELSFNNIRDADAAIRIIRDFKDR---PTVVALKHMNPCG--IGQAETIEQA------- 290
Query: 291 ELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLL 350
+S FG V L+ D +TA + + +IAPGYS EAL +L
Sbjct: 291 --------WDYAYEADPVSIFGGIVVLNREVDAATAEKMHPIFLEIIIAPGYSAEALAIL 342
Query: 351 SKKKGGNYCVLKIDPTYEPSLMEQKTIFGLT--LEQKRNDAKITAELFKNVVTTKKDLPS 408
+ KK N +L++ + + +K G+ L + D + + + VVT ++ PS
Sbjct: 343 TNKK-KNLRILELAFDAQDASEVEKEFTGVVGGLLVQDQDVVVESPVDWQVVTERQ--PS 399
Query: 409 NAV-RDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
+ A + KY +SN + D +G+G GQ +R+ R+A
Sbjct: 400 EQEWAAMEFAWKSSKYVKSNGIIITNDKMTLGVGPGQTNRVASVRIA 446
Score = 58.4 bits (135), Expect = 5e-07
Identities = 24/63 (38%), Positives = 38/63 (60%)
Query: 527 KMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRL 586
+++ LASDAFFPF DN++ G++ I P GS DQ+ I+ N++ + + T +R
Sbjct: 453 RLEGAVLASDAFFPFADNVEEIAAAGIKAIIQPGGSVRDQDSIDMANKYGLTMVFTGVRH 512
Query: 587 FHH 589
F H
Sbjct: 513 FRH 515
>UniRef50_A6G003 Cluster: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Plesiocystis
pacifica SIR-1|Rep: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Plesiocystis
pacifica SIR-1
Length = 543
Score = 248 bits (607), Expect = 3e-64
Identities = 169/481 (35%), Positives = 260/481 (54%), Gaps = 47/481 (9%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDK+ L LA+ L ++++++GGT AL G+ V VS+ T APE+L GRVK
Sbjct: 17 ALVSVSDKSKLDVLAEILIAHKVEVLSTGGTYRALSELGVAVVKVSEFTGAPEILDGRVK 76
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHP +H GILA +++ Q +++ I +V+ NLYPF +T++KP + ADA+ENIDI
Sbjct: 77 TLHPKIHGGILALPTEAHQRELELHDIAPIDLVIVNLYPFRETIAKPGCSFADAIENIDI 136
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GG T++RAAAKN +RV V+ DP DY + + E+ R+ +A KAF HT+ YD
Sbjct: 137 GGPTMVRAAAKNWNRVAVIVDPEDYSS-LSEVLGETEGTLPESFRRNMARKAFAHTAAYD 195
Query: 186 LAISDYFRKQ----------------YSPGQAQLTLRYGMNPHQKPAQVFTTRDSLPITT 229
AI+ Y + + G++ LRYG NPHQ+ T+ S T
Sbjct: 196 AAIASYLARHDDAGEALDAGTIPEGLFVSGESVAELRYGENPHQQARFFATSYASDEATG 255
Query: 230 LN-------GAPGFINLCDALNAWQLVKELKEAL--SLPAAASFKHVSPAGAAVGLPLTD 280
L+ A + NL DA A L+++LK L AAA FKH+SP GAA+G +D
Sbjct: 256 LDQAIVHQGKALSYNNLLDADAALGLIRDLKAGLPEGGKAAAVFKHLSPCGAAIG-SASD 314
Query: 281 EEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAP 340
E A V + A E S+FG V++++ D + A I + ++AP
Sbjct: 315 ELATVYVKAREADAE-------------SAFGGIVSVTEFVDAAMAARIKETFLEVIVAP 361
Query: 341 GYSPEALKLLSKKKGGNYCVLKIDPTYEP---SLMEQKTIFGLTLEQKRNDAKITAELFK 397
GY+PEA ++L+KKK +L+I +E + + +++ G L Q+ + + A
Sbjct: 362 GYTPEAREILAKKK--RLRLLEIPAMFEGRDLAPLRLRSVAGGLLVQREDLIGVAAA--A 417
Query: 398 NVVTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGK 457
V T++ ++ + L + K+ +SN++ +DG +G+G GQ SR+ R A +
Sbjct: 418 GEVPTQRKPSADELASLDLGQRVCKHVRSNAIVLVKDGVTVGVGGGQTSRVEAVRQAISR 477
Query: 458 A 458
A
Sbjct: 478 A 478
Score = 63.3 bits (147), Expect = 2e-08
Identities = 29/57 (50%), Positives = 37/57 (64%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
LASDAFFPFRD+ID A GV + P GS D++V+ AC+E +A+ T R F H
Sbjct: 487 LASDAFFPFRDSIDSAAAAGVVAVIQPGGSIKDKDVVAACDERGLAMVFTGERHFRH 543
>UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=71; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacillus subtilis
Length = 512
Score = 246 bits (602), Expect = 1e-63
Identities = 162/467 (34%), Positives = 245/467 (52%), Gaps = 47/467 (10%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDKT L+ K L+E G+++I++GGT L+ G+ V +S++T PE++ GR+K
Sbjct: 6 ALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENGVDVIGISEVTGFPEIMDGRLK 65
Query: 66 TLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +H G+LA R ++ + + I +VV NLYPF +T+SK DVT +A+ENID
Sbjct: 66 TLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVNLYPFKETISKEDVTYEEAIENID 125
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG +LRAA+KNH VTV+ DPADY V+ +IKE +L ++ LA K F HT+ Y
Sbjct: 126 IGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE--EGSVSLQKKRELAAKVFRHTAAY 183
Query: 185 DLAISDYFRK---QYSPGQAQLT------LRYGMNPHQKPAQVFTTRDSLPI-------T 228
D I+DY + P Q +T LRYG NPHQ+ A + T +LP+
Sbjct: 184 DALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGENPHQE-ATFYQT--ALPVKGSIAQAE 240
Query: 229 TLNGAP-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCM 287
L+G + N+ DA A Q+V+E E PAA + KH++P G G + +
Sbjct: 241 QLHGKELSYNNIKDADAAVQIVREFTE----PAAVAVKHMNPCGVGTGKTIAE------- 289
Query: 288 VAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEAL 347
S FG +AL+ D +TA + + +IAP +S EAL
Sbjct: 290 ----------AFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSFSQEAL 339
Query: 348 KLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLP 407
+L+ KK L + + GL ++ AE+ + TK++
Sbjct: 340 DVLTAKKNLRLVTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEI---SIPTKREPN 396
Query: 408 SNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
DL +A +K+ +SN++ A+D +G+GAGQ +R+ ++A
Sbjct: 397 EQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIA 443
Score = 53.2 bits (122), Expect = 2e-05
Identities = 24/58 (41%), Positives = 35/58 (60%)
Query: 532 ALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
AL SDA+FP D ++ A + GV I P GS D++ I+ +E+ IA+ T +R F H
Sbjct: 455 ALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIRHFKH 512
>UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=49; root|Rep: Bifunctional purine
biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Synechocystis sp. (strain PCC
6803)
Length = 511
Score = 246 bits (601), Expect = 2e-63
Identities = 169/463 (36%), Positives = 242/463 (52%), Gaps = 39/463 (8%)
Query: 6 ALLSVSDKTGLLSLAKSL-SECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRV 64
ALLSVSDK+G++ LA+ L +E LI+SGGTA L+ AG+ V VSD T APE+LGGRV
Sbjct: 5 ALLSVSDKSGIVELAQRLVNEFQFDLISSGGTAKTLKEAGVPVTKVSDYTGAPEILGGRV 64
Query: 65 KTLHPAVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENI 123
KTLHP +H GILAR SDQ D++ + +VV NLYPF QT++KP VTVA+AVE I
Sbjct: 65 KTLHPRIHGGILARRDLPSDQADLEANDIRPLDLVVVNLYPFEQTIAKPGVTVAEAVEQI 124
Query: 124 DIGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSD 183
DIGG ++RA AKN TV+ +P Y+A ++ ++E + L RQ+ A +AF T+
Sbjct: 125 DIGGPAMIRATAKNFAHTTVLTNPNQYEAYLQALQE--QGEIPLALRQQFAGEAFALTNA 182
Query: 184 YDLAISDYF-------RKQYS-PGQAQLTLRYGMNPHQKPAQVFTTRDS---LPITTLNG 232
YD AI++YF Q+ G + LRYG NPHQ T R++ L G
Sbjct: 183 YDQAIANYFSGLSGDSANQFGLSGTLRQPLRYGENPHQSAGWYQTGREATGWAKAEKLQG 242
Query: 233 AP-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGE 291
+ NL D A +++ E + PAA KH +P G A+ L +
Sbjct: 243 KELSYNNLVDLEAARRIINEFD--VREPAAVILKHTNPCGVALAPTLVE----------- 289
Query: 292 LSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLS 351
S+FG VAL+ P D TA + + + ++APG EA ++L+
Sbjct: 290 ------AYQKAFNADATSAFGGIVALNQPLDGPTAAAMVKTFLECIVAPGCDAEAQEILA 343
Query: 352 KKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAV 411
KK +L D PS K I G L Q +D + ++ V T+K +
Sbjct: 344 KKNNLRVLILP-DLATGPS-QTIKAIAGGFLVQSADDEREDPSTWQ--VVTEKQPSGEEL 399
Query: 412 RDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
+L A K+ +SN++ ++ +G+GAGQ +R+ +A
Sbjct: 400 AELAFAWKVCKHVKSNAITITKNKTTLGVGAGQMNRVGSVEIA 442
Score = 54.0 bits (124), Expect = 1e-05
Identities = 26/57 (45%), Positives = 34/57 (59%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
LASDAFFPF D++ A G+ I P GS DQ+ I+A NE + + T +R F H
Sbjct: 455 LASDAFFPFDDSVRTAAAAGITTIIQPGGSMRDQDSIQAANELGLVMIFTGVRHFLH 511
>UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Alphaproteobacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methylobacterium
extorquens PA1
Length = 581
Score = 244 bits (598), Expect = 4e-63
Identities = 184/475 (38%), Positives = 252/475 (53%), Gaps = 48/475 (10%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSVSDKTGL A +LS+ G++L+++GGT AL AGL V++VS++TR PEM+ GRVK
Sbjct: 60 ALLSVSDKTGLTDFAAALSQRGVELVSTGGTHRALTEAGLAVREVSELTRFPEMMDGRVK 119
Query: 66 TLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHPAVH G+LA R + Q + I ++V NLYPF +T+ K D VENID
Sbjct: 120 TLHPAVHGGLLAVRDNPEHQAALAAHGIGAIDLLVVNLYPFEETL-KAGKAYDDCVENID 178
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
+GG ++RAAAKNH V VV D +DY A++ E+ E+ + T TR+RLA KAF+ T+ Y
Sbjct: 179 VGGPAMIRAAAKNHADVAVVVDVSDYGAILAELAEHDGNLTAT-TRRRLAQKAFSRTASY 237
Query: 185 DLAISDYFR----KQYSP------GQAQLTLRYGMNPHQKPAQVFTTRDSLP-ITTLNGA 233
D AI+++ + +P G +LRYG NPHQ A P I T
Sbjct: 238 DAAIANWLAEVEGRDKAPTFKALGGTLAQSLRYGENPHQSAAFYRLPGTLRPGIATARQV 297
Query: 234 PG----FINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVG--LPLTDEEAAVCM 287
G + NL D A++ V E A + A A KH +P G A G L E+A C
Sbjct: 298 QGKELSYNNLNDTDAAYECVAEFDPART-AAVAIIKHANPCGVAEGPDLLAAYEQALAC- 355
Query: 288 VAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEAL 347
S+FG VAL+ P D A I ++ +IAP S EAL
Sbjct: 356 ------------------DPTSAFGGIVALNRPLDAEAARKIVEIFTEVIIAPDASEEAL 397
Query: 348 KLLSKKKGGNYCVLKIDPTYEPSLMEQ--KTIFGLTLEQKRNDAKITAELFKNVVTTKKD 405
++ KK N +L +P + +T+ G L Q R DA ++ VVT K
Sbjct: 398 AIVGAKK--NLRLLLAGGLADPRAKGEVIRTVAGGFLVQGR-DALSVDDMDLKVVT--KR 452
Query: 406 LPSNA-VRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAA 459
PS A + D+ A K+ +SN++ +A+ G +GIGAGQ SR+ + A KAA
Sbjct: 453 APSEAELADMRFAYRVAKHVKSNAIVYAKGGATVGIGAGQMSRVDSSITAARKAA 507
Score = 57.2 bits (132), Expect = 1e-06
Identities = 43/121 (35%), Positives = 60/121 (49%), Gaps = 4/121 (3%)
Query: 472 MRFRQGVTRAVQANAIDNYVNG-TVGSDL-PLEQWDTLFEGKPPALFTDSQREEWIKKMD 529
MRF V + V++NAI G TVG + + D+ A +QR + +
Sbjct: 462 MRFAYRVAKHVKSNAIVYAKGGATVGIGAGQMSRVDSSITAARKAAEA-AQRLGLSESLA 520
Query: 530 K-VALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFH 588
K A+ASDAFFPF D + A + G + P GS D EVI A +E +A+ T +R F
Sbjct: 521 KGSAVASDAFFPFADGLLAAAEAGATAVIQPGGSMRDDEVIRAADEAGLAMVFTGVRHFR 580
Query: 589 H 589
H
Sbjct: 581 H 581
>UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=9; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Aquifex aeolicus
Length = 506
Score = 244 bits (596), Expect = 7e-63
Identities = 175/468 (37%), Positives = 254/468 (54%), Gaps = 47/468 (10%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
A++SV K G+ LAK+L E G +++++GGTA LR G++V++VS+IT PE+L GRVK
Sbjct: 3 AIISVYRKEGIDKLAKALQELGYEIVSTGGTAKYLREKGISVKEVSEITGFPEILEGRVK 62
Query: 66 TLHPAVHAGILAR-LSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP VH GIL R + D+E++++ + I VVV NLYPF + + K +T D +E ID
Sbjct: 63 TLHPVVHGGILFRDWVEKDKEEIEKHGIKPIDVVVVNLYPFEEKL-KEGLTDKDLMEFID 121
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG TL+RAAAKN RV ++ DP DYD V++++K+ TL R LA KAF+HT+ Y
Sbjct: 122 IGGPTLIRAAAKNFFRVVILVDPEDYDWVIEKLKKG---NLTLQDRAYLAWKAFSHTAYY 178
Query: 185 DLAISDYFRKQYS----------PGQAQLTLRYGMNPHQKPAQVFTTRDSLPIT---TLN 231
D IS F+K YS P + LRYG NPHQ+ + + IT L
Sbjct: 179 DGVISQAFKKLYSIDTFGKEEALPLKRMQKLRYGENPHQRGFLYENPLEDIGITKAQVLQ 238
Query: 232 GAP-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAG 290
G F N DA +A +LV E + A KH +P G A+G
Sbjct: 239 GKEMSFNNYLDADSAVRLVAEFP---NQTVCAIIKHNNPCGVALG--------------- 280
Query: 291 ELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLL 350
S +S+FG VA +D D TA ++ + VIAP Y EAL+ L
Sbjct: 281 --SSVKEAFLRAKEADPVSAFGGIVAFNDKVDGETAKELTSMFLEVVIAPDYDEEALREL 338
Query: 351 SKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNA 410
S+KK N V++ ++ + +K G L+ + D + +L V TK++ +
Sbjct: 339 SRKK--NLRVIRFF-GFQHAFDVKKVSGGYLLQDE--DTVLYEKL---QVVTKREPTAEE 390
Query: 411 VRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
+ DL+ A +K+T+SN+V A++GQ +GIG+G SR+ + A KA
Sbjct: 391 MEDLLFAWKVVKHTKSNAVVIAKNGQTLGIGSGNVSRVDSLKCAINKA 438
Score = 69.3 bits (162), Expect = 3e-10
Identities = 32/57 (56%), Positives = 40/57 (70%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+AS+AFFPFRD+ID + G+ + P GS DQEVI+ACNEH IA+ T LR F H
Sbjct: 450 VASEAFFPFRDSIDIMAKEGITAVIQPGGSIRDQEVIDACNEHGIAMIFTGLRHFKH 506
>UniRef50_Q8PYG4 Cluster: Formyltransferase
phosphoribosylaminoimidazolecarboxamide; n=4;
Methanosarcinaceae|Rep: Formyltransferase
phosphoribosylaminoimidazolecarboxamide - Methanosarcina
mazei (Methanosarcina frisia)
Length = 538
Score = 239 bits (585), Expect = 1e-61
Identities = 178/474 (37%), Positives = 256/474 (54%), Gaps = 47/474 (9%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSVSDKTG++ A+ L G+++I++GGTA LR+A + V DVS++T PEM+GGRVK
Sbjct: 5 ALLSVSDKTGIVEFARGLEALGVKIISTGGTAKILRDADIEVTDVSEVTGYPEMMGGRVK 64
Query: 66 TLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +H G+L R S E+ ++ +I ++ NLYPF TVS+ +V + +A+ENID
Sbjct: 65 TLHPRIHGGLLCLRESKEQMEEAAKEDISLIDLIAVNLYPFEITVSRENVELEEAIENID 124
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG TLLR+AAKN+ VTV+ DP+DY ++KE++ + TR LA+KAF HT+DY
Sbjct: 125 IGGPTLLRSAAKNYRSVTVLSDPSDYGRILKELRSSGIISDK--TRAELAVKAFRHTADY 182
Query: 185 DLAISDYFRKQYSPGQA-------QLTLRYGMNPHQKPAQVFTTRDSLP----ITTLNGA 233
D AI Y + + + LRYG N HQK + P L+G
Sbjct: 183 DAAIDTYLSRTLLGEEVLHLKFADGVKLRYGENWHQKAYFYKDSAIKGPSLAKAIQLHGK 242
Query: 234 P-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGEL 292
+ N DA NA Q VKEL A PA A KH +P G A G L +A G+
Sbjct: 243 ELSYNNYVDADNALQTVKELGNA--SPAVAIVKHNNPCGLATGESLL--QALHSAWDGD- 297
Query: 293 SXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSK 352
+S++G + ++ D+ AT ++ + + ++AP + P+AL+ L K
Sbjct: 298 --------------PISAYGSIICTNEVFDLEAATFLNGKFVEIILAPDFKPDALEYL-K 342
Query: 353 KKGGNYCVLKIDPTYEPSLME--QKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNA 410
KK N +LK+ E E K + G L+Q R D I E +++V T+ P N
Sbjct: 343 KKSENLRLLKLPDLREGFGAEYTYKYVIGGMLKQSR-DIGI-YEKWESV--TEVPYPENK 398
Query: 411 VRDLIVATIALKYTQSNSVCFARDGQ-----VIGIGAGQQSRIHCTR-LAGGKA 458
A K T+SN+V A + + V+G+GAGQ +R+ R LA KA
Sbjct: 399 RALSEFCLKACKATKSNAVILAYEYEPGNFMVLGMGAGQPNRVDSIRKLAATKA 452
Score = 62.5 bits (145), Expect = 3e-08
Identities = 39/110 (35%), Positives = 58/110 (52%), Gaps = 7/110 (6%)
Query: 481 AVQANAIDNYVNGTVGSDLPLEQWDTLFEGKPPALFTDSQREEWIKK-MDKVALASDAFF 539
A Q N +D+ + + +E ++E + PA+ EE+ +K M + +ASDAFF
Sbjct: 435 AGQPNRVDSIRK--LAATKAVENLKVIYEREQPAV----PFEEYCQKIMSECVMASDAFF 488
Query: 540 PFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
PF D++ A + + YI SP GS D EVI N +AL T +R F H
Sbjct: 489 PFDDSVVHAAENNIRYIVSPGGSIRDNEVIATANRLGVALVFTGMRHFLH 538
>UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=18; Staphylococcus|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Staphylococcus aureus (strain Mu50
/ ATCC 700699)
Length = 492
Score = 237 bits (581), Expect = 5e-61
Identities = 163/454 (35%), Positives = 245/454 (53%), Gaps = 39/454 (8%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
A+LSVS+KTG++ AK+L++ +L ++GGT L A + V+ VSD+T PE++ GRVK
Sbjct: 4 AILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGRVK 63
Query: 66 TLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHPAVH GILA R ++ Q ++I +VV NLYPF QTV+ PDVT+ +A+ENID
Sbjct: 64 TLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAIENID 123
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG T+LRAAAKN+ VT + PADY V+ ++ + ++ RQ L +K F HT++Y
Sbjct: 124 IGGPTMLRAAAKNYKHVTTIVHPADYHEVLTRLRNDSLDES---YRQSLMIKVFEHTAEY 180
Query: 185 DLAISDYFRKQYSPGQAQLTLRYGMNPHQKPAQVFTTRDSLPIT---TLNGAP-GFINLC 240
D AI +F+ G + TLRYG NP Q V T+ I L+G + N+
Sbjct: 181 DEAIVRFFK-----GDKE-TLRYGENPQQSAYFVRTSNAKHTIAGAKQLHGKQLSYNNIK 234
Query: 241 DALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXXXXX 300
DA LVK+ PAA + KH++P G VG+ T E+A
Sbjct: 235 DADATLALVKK----FDTPAAVAVKHMNPCG--VGIGDTIEQA---------------FQ 273
Query: 301 XXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCV 360
S FG VAL+ A + + +IAP ++ EAL +L +KK N +
Sbjct: 274 HAYEADSQSIFGGIVALNRAVTPELAEQLHSIFLEVIIAPKFTDEALDILKQKK--NVRL 331
Query: 361 LKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVATIA 420
L+ID T + + E ++ G L Q +++ + E K V T+ +++
Sbjct: 332 LEIDMTIDSNEEEFVSVSGGYLVQDKDNYVVPKEEMK--VVTEVAPTDEQWEAMLLGWKV 389
Query: 421 LKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
+ +SN++ + + Q +GIGAGQ +R+ ++A
Sbjct: 390 VPSVKSNAIILSNNKQTVGIGAGQMNRVGAAKIA 423
Score = 59.7 bits (138), Expect = 2e-07
Identities = 30/68 (44%), Positives = 39/68 (57%)
Query: 522 EEWIKKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAH 581
E I+ D VAL SD FFP D ++ A Q G++ I P GS DQ+ I+ N+H IA+
Sbjct: 425 ERAIEINDHVALVSDGFFPMGDTVELAAQHGIKAIIQPGGSIKDQDSIDMANKHGIAMVV 484
Query: 582 TNLRLFHH 589
T R F H
Sbjct: 485 TGTRHFKH 492
>UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=6; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Leptospira interrogans
Length = 511
Score = 226 bits (552), Expect = 1e-57
Identities = 168/499 (33%), Positives = 257/499 (51%), Gaps = 48/499 (9%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDK+GL+ AK L++ G+++I++GGT L++ G+ + D T PE+L GRVK
Sbjct: 7 ALISVSDKSGLVEFAKFLNQNGVEIISTGGTLKLLKDNGIAAIAIDDYTGFPEILDGRVK 66
Query: 66 TLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP VH G+L +S+ + ++ M+ K I +VV NLYPF++TVSKP+V + +A+ENID
Sbjct: 67 TLHPKVHGGLLGVISNPAHKQKMEELKIPKIDLVVVNLYPFLKTVSKPEVQLEEAIENID 126
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG +++R+AAKN+ V+ DP DY + I + + + R KAF+HT+ Y
Sbjct: 127 IGGPSMIRSAAKNYKHTLVLTDPNDYKKIQNLISSSGISEEISASYMR---KAFSHTAMY 183
Query: 185 DLAISDYFRKQYS---PGQAQLT------LRYGMNPHQKPA---QVFTTRDSLPITTLNG 232
D AIS +F KQ P L+ LRYG NPHQ + +FT D P+
Sbjct: 184 DAAISSWFYKQSGEVFPDVLNLSFIKKQKLRYGENPHQAASFYEPLFTKSDFSPLQ--GK 241
Query: 233 APGFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGEL 292
F N+ D A+ + L E KH++P G A D +A
Sbjct: 242 ELSFNNMLDFDAAFHISSLLPE----NTVCIIKHLNPCGIA----YADNPLEAFQLA--- 290
Query: 293 SXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSK 352
+S+FG + + + AT I+ +GVIA ++ EAL++ SK
Sbjct: 291 ----------RRTDPISAFGGVIGIKGQVNGELATSITENFVEGVIAQKFTQEALEVFSK 340
Query: 353 KKGGNYCVLKIDPTYEP-SLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAV 411
K N +++I E ++ + I L Q R+ IT + K VVT K+ P + +
Sbjct: 341 KP--NIRLIEIQDFKEALDELDLRPIHHGLLIQDRDYTTITEKDLK-VVTKKQPSPDD-I 396
Query: 412 RDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAALWWLRRHPSVLA 471
R L+ A +++ +SN++ + + +GIGAGQ SR+ +L KA L S +A
Sbjct: 397 RGLMFAWSCVRFIKSNAIVYTEENATLGIGAGQMSRVDSVQLGANKALNVGLSVVGSYVA 456
Query: 472 ----MRFRQGVTRAVQANA 486
FR G+ +A A
Sbjct: 457 SDAFFPFRDGIDALAKAGA 475
Score = 63.3 bits (147), Expect = 2e-08
Identities = 28/57 (49%), Positives = 37/57 (64%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASDAFFPFRD ID + G + I P GS D+EVI+A +EH + + T +R F H
Sbjct: 455 VASDAFFPFRDGIDALAKAGAKAIIQPGGSVRDEEVIQAADEHGLIMVFTGMRHFRH 511
>UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=3; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Deinococcus radiodurans
Length = 510
Score = 225 bits (550), Expect = 3e-57
Identities = 166/463 (35%), Positives = 236/463 (50%), Gaps = 52/463 (11%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDKTG++ A L + G +L+++GGT L AG+ V+ VSD+T PEML GRVK
Sbjct: 5 ALISVSDKTGVVEFAAQLQQRGWELLSTGGTFATLSGAGIPVRQVSDVTGFPEMLDGRVK 64
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSK--PDVTVADAVENI 123
TLHPA+H GILAR + Q I +V NLYPF +TV++ PD + +ENI
Sbjct: 65 TLHPAIHGGILARREAGHLGQLAAQDIGTIDLVCVNLYPFRETVARGAPD---PEVIENI 121
Query: 124 DIGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSD 183
DIGG ++R+AAKNHD V V+ DPADY +++ + + R+RLA KA+ HTS+
Sbjct: 122 DIGGPAMIRSAAKNHDAVLVLVDPADYALALQD-------EVSPAERRRLAAKAYRHTSE 174
Query: 184 YDLAISDYFRKQYSPGQAQL------------TLRYGMNPHQKPAQVFTTRDS----LPI 227
YD AI+ Y + QL +RYG NPHQ P ++ ++ +
Sbjct: 175 YDAAITAYLSGESDELPTQLPEHLSLDLTRTAQVRYGENPHQ-PGAIYRWGNARGPVIDA 233
Query: 228 TTLNGAP-GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVC 286
+ G P F N DA AW L +EL + KH +P G AV AA
Sbjct: 234 QVVAGKPMSFNNYADADAAWSLCQELAAQEQGAVCVAVKHANPCGVAV--------AADV 285
Query: 287 MVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEA 346
A E +S FG VA+S P D A + + +IAP +P+A
Sbjct: 286 KTAWE---------RARDADTLSVFGGVVAVSQPVDFGAAQSMKGTFLEVLIAPDVTPDA 336
Query: 347 LKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDL 406
++ + KK + VL S+++ + + G Q+R DA+ +L VVT ++
Sbjct: 337 VEWFAAKK-PDLRVLIAGQPQGVSVLDVRPLTGGFAVQER-DARPWDDLCPEVVTERQ-- 392
Query: 407 PSNAV-RDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRI 448
PS DL A +K +SN+V + G +G+GAG SRI
Sbjct: 393 PSEQEWADLRFAWAVVKGARSNAVALCKGGVTVGLGAGAVSRI 435
Score = 55.6 bits (128), Expect = 3e-06
Identities = 27/57 (47%), Positives = 33/57 (57%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
LAS+AFFPF D + A GV + P G+ D EVI ACNE I++ T R F H
Sbjct: 454 LASEAFFPFDDVVRLAASAGVTAVLQPGGAKRDPEVIAACNELGISMVFTGSRHFRH 510
>UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2;
Arthrobacter|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Arthrobacter sp.
(strain FB24)
Length = 559
Score = 224 bits (548), Expect = 4e-57
Identities = 168/475 (35%), Positives = 235/475 (49%), Gaps = 44/475 (9%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SV DKTGL LAK L E G++++++G TA + AG+ VQ+V ++T +PEML GRVK
Sbjct: 14 ALISVYDKTGLEELAKGLHEAGVKIVSTGSTAKKIAAAGIPVQEVEEVTGSPEMLDGRVK 73
Query: 66 TLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP VH GILA R + E + + E +VV NLYPFV+TV K D VE ID
Sbjct: 74 TLHPRVHGGILADRRVPAHMETLAGMEIEAFDLVVVNLYPFVETV-KSGAAQDDVVEQID 132
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG ++R+AAKNH V +V DP Y VV+ E L TRQRLA KAF HT+ Y
Sbjct: 133 IGGPAMVRSAAKNHAAVAIVTDPNFYGDVVRAAAEGGF---DLKTRQRLAAKAFAHTASY 189
Query: 185 DLAISDYFRKQYS----------PGQAQL------TLRYGMNPHQKPAQVFTTRDSLPIT 228
D A++ + Q+ P A L LRYG NPHQ+ A I
Sbjct: 190 DTAVATWTASQFLDEDGDGVIDWPAYAGLALERSEVLRYGENPHQQAALYVDKAAPAGIA 249
Query: 229 ---TLNG-APGFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAA 284
++G A + N DA A + + E PA A KH +P G AVG +AA
Sbjct: 250 QADQIHGKAMSYNNFVDADAALRAAFDFAE----PAVAIIKHANPCGVAVG----SADAA 301
Query: 285 VCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSP 344
+S+FG +A + A ++ ++ VIAPG+
Sbjct: 302 --------DPIADAHAKAHACDPVSAFGGVIAANRTVTAGMARTVAGIFTEVVIAPGFED 353
Query: 345 EALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKN-VVTTK 403
EA+++LSKKK N +L + Y E + + G L Q + + N +
Sbjct: 354 EAVEILSKKK--NIRLLALPEGYGRYPTEFRQVSGGMLVQAADKVDAEGDNPANWTLAAG 411
Query: 404 KDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
+ + + DL A A + +SN++ A G +GIG GQ +R+ +LA +A
Sbjct: 412 EAADAATLADLAFAWTACRAAKSNAILLADHGAAVGIGMGQVNRLDSCKLAVERA 466
Score = 50.8 bits (116), Expect = 1e-04
Identities = 25/56 (44%), Positives = 29/56 (51%)
Query: 534 ASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
ASDAFFPF D + + GV + P GS D EVI A N I + T R F H
Sbjct: 504 ASDAFFPFADGLQILIDAGVRAVVQPGGSVRDDEVIAAANAAGITMYFTGARHFFH 559
>UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Methanomicrobiales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 497
Score = 224 bits (547), Expect = 6e-57
Identities = 166/474 (35%), Positives = 247/474 (52%), Gaps = 43/474 (9%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSV DKTG+L LA++L + +++SGGTA ALR AG+ +DVS+ T+ PEM+ GRVK
Sbjct: 4 ALLSVWDKTGILDLARALVAKNIGILSSGGTAKALREAGIPAKDVSEYTQFPEMMDGRVK 63
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHP VH G+L R D + MK E I ++ NLYPF + +SK ++ + + +E IDI
Sbjct: 64 TLHPKVHGGLLGR-RGIDDDVMKAHFIEPIDILCVNLYPF-EEMSKKNLPLEELIEFIDI 121
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GG ++RAA+KN+ V V+ DP+DY ++ IK T + RLA KAFT T+ YD
Sbjct: 122 GGPAMIRAASKNYKDVAVLTDPSDYPMAIEAIKTGGF---TSEQKLRLATKAFTRTAAYD 178
Query: 186 LAISDYFR---KQYSPGQAQ-----LTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPGFI 237
AIS+Y K++ LRYG NPHQK A T+ + + +
Sbjct: 179 AAISNYLNGIDKEFPDVYTMQFGNGRKLRYGENPHQKAAVYGTSGIAGQVALQGKEMSYN 238
Query: 238 NLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXX 297
N D A L +EL A KH +P G A+G + + A ++
Sbjct: 239 NYLDVHAAVSLCRELPGF----ATVIVKHNNPCGVALG----KNQLESYIKARDVD---- 286
Query: 298 XXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGN 357
+S++G VA+S P D A I + +IAP +S EA +++ KK+
Sbjct: 287 ---------PVSAYGSIVAMSTPVDTDIAKEICSTFVEVLIAPSFSDEAREMMKKKENMR 337
Query: 358 YCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVA 417
+L P EP+ E +TI G L Q+ E +K V +K+ + V L +A
Sbjct: 338 LLIL---PPAEPA-DEIRTIDGGILVQR---TPAYTEDWK--VVSKRAPTPDEVEALKLA 388
Query: 418 TIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAALWWLRRHPSVLA 471
++Y +SN++ +A + +GIG GQ +R+ +LA KAA + +V+A
Sbjct: 389 WKVVEYAKSNAIIYANKTETVGIGVGQMNRVDSAKLAIQKAAEFGRTMQGTVIA 442
Score = 51.6 bits (118), Expect = 6e-05
Identities = 36/121 (29%), Positives = 55/121 (45%), Gaps = 5/121 (4%)
Query: 469 VLAMRFRQGVTRAVQANAIDNYVNGTVGSDLPLEQWDTLFEGKPPALFTDSQREEWIKKM 528
V A++ V ++NAI Y N T + + Q + + K + E+ + M
Sbjct: 382 VEALKLAWKVVEYAKSNAII-YANKTETVGIGVGQMNRVDSAK----LAIQKAAEFGRTM 436
Query: 529 DKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFH 588
+ASDAF PF D ++ A G + P GS D EV+ +E IA+ T +R F
Sbjct: 437 QGTVIASDAFLPFSDTLEVAAAAGATALIQPGGSIRDDEVLAKADELGIAMVFTGVRHFR 496
Query: 589 H 589
H
Sbjct: 497 H 497
>UniRef50_Q95QQ5 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 420
Score = 222 bits (542), Expect = 2e-56
Identities = 100/184 (54%), Positives = 131/184 (71%), Gaps = 1/184 (0%)
Query: 406 LPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAALWWLRR 465
L A+ DLIVATIALKY QSNSVCFA GQVIG+GAGQQSRIHCTRLAG KA WWLR+
Sbjct: 238 LNKQAIDDLIVATIALKYAQSNSVCFAHRGQVIGMGAGQQSRIHCTRLAGDKAMNWWLRQ 297
Query: 466 HPSVLAMRFRQGVTRAVQANAIDNYVNGTVGSDLPLEQWDTLFEGKPPALFTDSQREEWI 525
HP+VL++ ++ + R+ ++NAID +G +GS++ ++QW F +P + R++W+
Sbjct: 298 HPTVLSLPWKNAIKRSEKSNAIDVLCSGVLGSEIAIDQWQQYF-NEPVEPLAEDDRKQWL 356
Query: 526 KKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLR 585
+ V ++SDAF PFRDN+D A Q GV Y+ P GS D ++ EAC+EH I L HT LR
Sbjct: 357 SQQTGVVMSSDAFLPFRDNVDCAKQFGVSYVAHPGGSVRDDDIKEACDEHGITLIHTGLR 416
Query: 586 LFHH 589
LFHH
Sbjct: 417 LFHH 420
Score = 200 bits (487), Expect = 1e-49
Identities = 108/204 (52%), Positives = 131/204 (64%), Gaps = 22/204 (10%)
Query: 225 LPITTLNGAPGFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEE-- 282
+PI LNG+PG+IN+ D LN WQLVKEL +A +PAAASFKHVSPAGAAVGLPL + E
Sbjct: 1 MPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVSPAGAAVGLPLNETEAA 60
Query: 283 ----------------AAVCMVAGE----LSXXXXXXXXXXXXXXMSSFGDFVALSDPCD 322
AA A E ++ MSSFGDF+ALS+ CD
Sbjct: 61 CCMVSDLPIDTKKPSLAAAYARAREQDWMIADRLQRIAPSIGADRMSSFGDFIALSEKCD 120
Query: 323 VSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTL 382
TA II+REVSDGV+AP + P AL LL+KKK GNYCVLKI+P Y PS E++T+FGL L
Sbjct: 121 ELTAKIINREVSDGVVAPDFDPAALSLLAKKKNGNYCVLKINPNYLPSETEERTVFGLRL 180
Query: 383 EQKRNDAKITAELFKNVVTTKKDL 406
QKRN+A I AE F NVV + ++
Sbjct: 181 RQKRNNAVINAETFNNVVGSANEV 204
>UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=14; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Clostridium perfringens
Length = 501
Score = 218 bits (533), Expect = 3e-55
Identities = 170/462 (36%), Positives = 248/462 (53%), Gaps = 44/462 (9%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SV DK G+L LAK L + +++I+SGGT L+ + V+++S+IT PEML GRVK
Sbjct: 5 ALISVFDKDGVLELAKFLRDRDVEIISSGGTYKYLKENNIEVKEISEITDFPEMLDGRVK 64
Query: 66 TLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP VHAGILA R + + ++ ++ I VV NLYPF + V + D++ + VE ID
Sbjct: 65 TLHPLVHAGILAIRDNKEHMKTLEEREINTIDYVVVNLYPFFEKV-REDLSFEEKVEFID 123
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG T+LRAAAKN V V+ D DY+ V+ EIKEN + + R+ LA K F S Y
Sbjct: 124 IGGPTMLRAAAKNFKDVVVLSDKKDYEKVMNEIKEN--NCVSFKLRKTLAGKVFNLMSAY 181
Query: 185 DLAISDYF---RKQY----SPGQAQL-TLRYGMNPHQKPAQVFTTRDSLPITT---LNG- 232
D AIS++ ++Y S ++ LRYG NPHQ A +T + + LNG
Sbjct: 182 DAAISNFLLEGEEEYPEYLSVSYKKIQDLRYGENPHQGAAYYSSTEFDGAMNSFEILNGK 241
Query: 233 APGFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGEL 292
A + N+ D AW++ E +E A + KH +P G AVG + V + A +
Sbjct: 242 ALSYNNIKDLDIAWKVACEFEET----ACCALKHNTPCGVAVG----ENSKEVYLKAYD- 292
Query: 293 SXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSK 352
+S FG VA++ D +TA + + + V AP + +AL++L
Sbjct: 293 ------------ADPVSIFGGIVAINRKIDKATAEEMVKIFLEVVAAPDFDEDALEVLRT 340
Query: 353 KKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVR 412
KK N V+K T + + T+ G L Q D K+ E +K V T+K+ +R
Sbjct: 341 KK--NLRVIKCKNTPQ-AKNYMVTVDGGILVQ-GEDNKLANE-YK--VVTEKEPTEMELR 393
Query: 413 DLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
D+I +KY +SN++ +DG GIG GQ +RI T+ A
Sbjct: 394 DMIFGMKVVKYVKSNAIVVVKDGVATGIGGGQVNRIWATKEA 435
Score = 70.5 bits (165), Expect = 1e-10
Identities = 32/57 (56%), Positives = 40/57 (70%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
LASDAFFPFRD +D A + G++ I P GS D+E IEACNEH I++ T +R F H
Sbjct: 445 LASDAFFPFRDCVDEAAKNGIKAIIQPGGSIRDEESIEACNEHGISMVFTGVRHFKH 501
>UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protein
PurH; n=12; Bacteria|Rep: Bifunctional purine
biosynthesis protein PurH - Synechococcus sp. (strain
JA-3-3Ab) (Cyanobacteria bacteriumYellowstone A-Prime)
Length = 537
Score = 218 bits (532), Expect = 4e-55
Identities = 180/479 (37%), Positives = 240/479 (50%), Gaps = 50/479 (10%)
Query: 6 ALLSVSDKTGLLSLAKSL-SECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRV 64
ALLSVSDKTGL+ LA++L E G QL++SGGTA AL AG+ V VS+ T APE+LGGRV
Sbjct: 10 ALLSVSDKTGLIPLAQALVQEHGFQLLSSGGTAKALSEAGIPVTPVSEHTGAPEILGGRV 69
Query: 65 KTLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENI 123
KTLHP +H GILARL D+ D++ I +VV N YPF QTV++ V++ +A E I
Sbjct: 70 KTLHPRIHGGILARLERREDRADLEALGIPPIQLVVVNFYPFEQTVARAGVSLEEAFEQI 129
Query: 124 DIGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSD 183
DIGG TL RAAAKN+ VTV+ DP+ Y ++ + L R + A +AF
Sbjct: 130 DIGGPTLARAAAKNYPHVTVLTDPSQYPQYLQLLSSPSSEAERLAFRFQCARRAFEQVLA 189
Query: 184 YDLAISDYF-RKQYS-PGQA-----------QL------TLRYGMNPHQKPAQVFTTRDS 224
YD AI DY R + S P QA QL LRYG NPHQ A + +
Sbjct: 190 YDRAIVDYLTRSELSRPSQAPAPATAAEQVFQLQGIPWQRLRYGENPHQ-AATWYVVDAA 248
Query: 225 LP----ITTLNGAP-GFINLCDALNAWQLVKELKEALS---LPAAASF-KHVSPAGAAVG 275
P L G + NL D A L EL L+ PA A KH +P G AV
Sbjct: 249 APGWHRAKQLQGKELSYNNLLDLEAARALAAELSLGLANGPRPAVAVIVKHNNPCGVAVR 308
Query: 276 LPLTDEEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSD 335
L AA A +S+FG VAL+ D A ++ +
Sbjct: 309 PTL----AAAFEAA-------------LAADPVSAFGGIVALNQTLDGEAARRLAEPFLE 351
Query: 336 GVIAPGYSPEALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAEL 395
V+ P +PEA + L+ KK VL D P+ +T+ G L Q+ + A+ +
Sbjct: 352 CVVVPDCTPEAAEQLAAKKNLRLLVLP-DFAVGPA-QTVRTLAGGFLVQEADLAQGSDRR 409
Query: 396 FKNVVTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
V +++ DL A K+ +SN++ AR GQ +GIGAGQ +R+ +A
Sbjct: 410 PSWRVVSERQPTPEEWADLEFAWTVCKHVKSNAIVVARQGQTLGIGAGQMNRVGAVEIA 468
Score = 52.0 bits (119), Expect = 4e-05
Identities = 25/57 (43%), Positives = 33/57 (57%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
LASD FFPF D+++ A + G+ I P GS D + I A N IA+ T +R F H
Sbjct: 481 LASDGFFPFADSVEAAARAGIRAIIQPGGSLRDADSIAAANAAGIAMVCTGIRHFLH 537
>UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n=1;
unknown|Rep: UPI00015BCE7E UniRef100 entry - unknown
Length = 506
Score = 216 bits (528), Expect = 1e-54
Identities = 168/467 (35%), Positives = 244/467 (52%), Gaps = 45/467 (9%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SV DKTG+L LAK L G ++++SGGT T L+NAG+ +VS++T E+LGGRVK
Sbjct: 3 ALISVYDKTGILELAKELLNQGYEILSSGGTYTYLKNAGVDAIEVSEVTGFREILGGRVK 62
Query: 66 TLHPAVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHPA+H GIL R + D E++K E I +VV NLYPF + + K + VE ID
Sbjct: 63 TLHPAIHGGILFREDVEKDLEEIKENSIEPIDIVVVNLYPFEKKM-KELKDIDALVEFID 121
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG TL+RAAAKNH RV+V+ D DY ++++K N Q R+ LALKAF TS Y
Sbjct: 122 IGGPTLVRAAAKNHKRVSVLTDIEDYGWFIEKLKMNAVSQQ---DRKYLALKAFWLTSYY 178
Query: 185 DLAISDYFRKQYS-----------PGQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGA 233
D I+ YF K + P + LRYG NPHQ+ + I +
Sbjct: 179 DAVIASYFSKVFGFSEKDFKHHTVPMFLRDELRYGENPHQQAYLYENPLEENGIVRADVL 238
Query: 234 PG-FINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGEL 292
G ++ + L+A +VK + E S P A KH +P+G + + E
Sbjct: 239 QGKKMSYNNYLDADSVVKLMSE-FSNPCCAIVKHNNPSGITTDNNILEAYKKAFQCDPE- 296
Query: 293 SXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSK 352
++FG VA + D A I+ + VIAP ++ EA++ SK
Sbjct: 297 ----------------AAFGGIVAFNKVVDKDVAKAITEHFYEIVIAPEFTEEAVEEFSK 340
Query: 353 KKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPS-NAV 411
KK N +++ Y ++ + ++I G L Q +D +L++++ P+ +
Sbjct: 341 KK--NLRLVRY-KNYNQNI-DLRSISGGFLVQDIDD-----KLYESIEIVSLRRPTEQEL 391
Query: 412 RDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
D I A K+T+SN++ A++ Q IGIGAGQ SR+ R A KA
Sbjct: 392 EDAIFAWKVAKWTKSNAIVIAKNNQTIGIGAGQVSRVDSLRSAIRKA 438
Score = 64.5 bits (150), Expect = 8e-09
Identities = 30/57 (52%), Positives = 39/57 (68%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASDAFFPFRD+ID A + G+ P GS D+EVIEA NEH + + T++R F H
Sbjct: 450 VASDAFFPFRDSIDIAAEEGISGTIQPGGSIRDKEVIEAVNEHNMFMIFTHMRHFRH 506
>UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protein
PurH; n=1; Synechococcus sp. JA-2-3B'a(2-13)|Rep:
Bifunctional purine biosynthesis protein PurH -
Synechococcus sp. (strain JA-2-3B'a(2-13))
(Cyanobacteria bacteriumYellowstone B-Prime)
Length = 577
Score = 213 bits (521), Expect = 8e-54
Identities = 175/493 (35%), Positives = 238/493 (48%), Gaps = 46/493 (9%)
Query: 6 ALLSVSDKTGLLSLAKSL-SECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRV 64
ALLSVSDKTGL+ LA+SL E G QL++SGGTA AL AG+ V VS T APE+LGGRV
Sbjct: 18 ALLSVSDKTGLIPLAQSLVQEHGFQLLSSGGTAKALSEAGIPVTPVSAHTGAPEILGGRV 77
Query: 65 KTLHPAVHAGILARLSDS-DQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENI 123
KTLHP +H GILARL S D+ D++ I +VV N YPF QTV++ V++ +A E I
Sbjct: 78 KTLHPRIHGGILARLECSEDRADLEALGIPPIQLVVVNFYPFEQTVAQAGVSLEEAFEQI 137
Query: 124 DIGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSD 183
DIGG TL RAAAKN+ VTV+ DP+ Y ++ + L R + A +AF
Sbjct: 138 DIGGPTLARAAAKNYPYVTVLTDPSQYPRYLQLLSGAYGETERLAFRFQCARRAFEQVLA 197
Query: 184 YDLAISDYFRKQYSPGQAQLT-----------------LRYGMNPHQKPAQVFTTRDSLP 226
YD AI Y + G +Q + LRYG NPHQ A + T + P
Sbjct: 198 YDRAIVTYLARLELAGPSQSSAAAAEDRFQLQGILWQRLRYGENPHQ-AATWYVTDPAAP 256
Query: 227 ----ITTLNGAP-GFINLCDALNAWQLVKELKEALSLPAA---ASFKHVSPAGAAVGLPL 278
L G + NL D A L EL L A K +G+A L
Sbjct: 257 GWHRAKQLQGKELSYNNLLDLEAARALAAELTLLLRNADATRPTDGKGSVSSGSARREFL 316
Query: 279 TDEEAAVCMV-------AGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISR 331
E+A +V +S+FG VAL+ P D TA +
Sbjct: 317 QPEQAVAVVVKHNNPCGVAIRPSPAAALEAALAADPVSAFGGIVALNQPLDAETARRLVE 376
Query: 332 EVSDGVIAPGYSPEALKLLSKKKGGNYCVLK---IDP-----TYEPSLMEQKTIFGLTLE 383
+ V+AP +PEA +LLS KK +L + P T + Q + L+
Sbjct: 377 PFLECVVAPDCTPEAAELLSVKKNLRVLILPDLCVGPAQTIRTLAGGFLVQDADSPVALQ 436
Query: 384 QKRNDAKITAELFKN--VVTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIG 441
+ R+ + + VVT ++ P DL A I K+ +SN++ A+ Q +G+G
Sbjct: 437 RCRDQEPTQTDSPPSWQVVTQRQPTPEEWA-DLEFAWIVCKHVKSNAIVVAKQRQTLGVG 495
Query: 442 AGQQSRIHCTRLA 454
AGQ +R+ +A
Sbjct: 496 AGQMNRVGAAEIA 508
Score = 53.6 bits (123), Expect = 1e-05
Identities = 26/57 (45%), Positives = 33/57 (57%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
LASD FFPF D+++ A Q G+ I P GS D + I A N IA+ T +R F H
Sbjct: 521 LASDGFFPFADSVEMAAQAGIRAIIQPGGSIRDADSIAAANAAGIAMVCTGIRHFLH 577
>UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=14;
Viridiplantae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Nicotiana tabacum
(Common tobacco)
Length = 612
Score = 213 bits (519), Expect = 1e-53
Identities = 159/473 (33%), Positives = 238/473 (50%), Gaps = 38/473 (8%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+S+SDKT L L L E G ++++GGT++AL AG++V V ++TR PEML GRVK
Sbjct: 91 ALISLSDKTDLAKLGNGLQELGYTIVSTGGTSSALEGAGVSVTKVEELTRFPEMLDGRVK 150
Query: 66 TLHPAVHAGILARL-SDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPD-VTVADAVENI 123
TLHP+VH GILAR + E +++ + VVV NLYPF VS ++ D +ENI
Sbjct: 151 TLHPSVHGGILARRDQEHHMEALEKHEIGTFDVVVVNLYPFYAKVSSSSGISFEDGIENI 210
Query: 124 DIGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSD 183
DIGG ++RAAAKNH V VV D DY A+++ ++ + Q R++LA KAF H +
Sbjct: 211 DIGGPAMIRAAAKNHRDVLVVVDSEDYPALLEFLRGDNDDQQ---FRRKLAWKAFQHVAS 267
Query: 184 YDLAISDYFRKQ-----YSPG-----QAQLTLRYGMNPHQKPA----QVFTTRDSLPITT 229
YD A+S++ KQ + PG + LRYG NPHQK A + + ++ I T
Sbjct: 268 YDSAVSEWLWKQTVGDKFPPGLTVPLHLKSLLRYGENPHQKAAVYVDKSLSEVNAGGIAT 327
Query: 230 LNGAPG----FINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAV 285
+ G + N DA AW V E + P KH +P G A + EA
Sbjct: 328 VIQHHGKEMSYNNYLDADAAWNCVCEFNK----PTCVVVKHTNPCGVASRNDII--EAYR 381
Query: 286 CMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPE 345
V + + D P D T R + V+AP Y+ +
Sbjct: 382 LAVKADPVSAFGGIVAFNVEVDEALAKDIREFRSPTDGET-----RMFYEIVVAPKYTEK 436
Query: 346 ALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKD 405
L++L + K +L+ + L + I G L Q +D +T E + V + K
Sbjct: 437 GLEVL-RGKSKTLRILEASKNSKGKL-SLRQIGGGWLAQDSDD--LTPEDIQFNVMSDKT 492
Query: 406 LPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
N + D A + +K+ +SN++ A++ ++G+G+GQ +R+ R+A KA
Sbjct: 493 PQENELNDAQFAWLCVKHVKSNAIVIAKNNCMLGMGSGQPNRLESLRIAMRKA 545
Score = 62.9 bits (146), Expect = 2e-08
Identities = 28/60 (46%), Positives = 39/60 (65%), Gaps = 2/60 (3%)
Query: 532 ALASDAFFPF--RDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
ALASDAFFPF D ++ A Q GV I P GS D++ ++ CN++ ++L TN+R F H
Sbjct: 553 ALASDAFFPFAWNDAVEEACQSGVSVIAEPGGSIRDKDAVDCCNKYGVSLVFTNVRHFRH 612
>UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protein;
n=2; Candidatus Pelagibacter ubique|Rep: Bifunctional
purine biosynthesis protein - Candidatus Pelagibacter
ubique HTCC1002
Length = 518
Score = 211 bits (515), Expect = 4e-53
Identities = 142/460 (30%), Positives = 243/460 (52%), Gaps = 38/460 (8%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDK L SL + L++ ++LI+SGGT ++ Q+VS+ T +PE+LGGRVK
Sbjct: 14 ALISVSDKKDLGSLLRVLAKYKIELISSGGTFKEIKKLKFKCQEVSEYTGSPEILGGRVK 73
Query: 66 TLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +HAGIL++ +D S +++K +Y+ I +V+ N YPF +T+ + + +ENID
Sbjct: 74 TLHPKIHAGILSKRNDKSHTKELKANQYDEIDLVIVNFYPFEKTLDQ-TTNHSKIIENID 132
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
+GG T++RAAAKN++ VTV+ Y+ ++ E++ NK T++ R++++L+AF+ T+ Y
Sbjct: 133 VGGPTMVRAAAKNYNDVTVITSSDQYETLINELENNK-GSTSIEFREKMSLEAFSETAYY 191
Query: 185 DLAISDYF---------RKQYSPGQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAP- 234
D IS+YF +K+ G LRYG NPHQ+ A +++ +L I ++G
Sbjct: 192 DAVISNYFNKIKKNNFPKKKIIYGNLIEKLRYGENPHQE-AAIYSKTQNLNIKQIHGKQL 250
Query: 235 GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSX 294
+ N D +A + K L + KH +P G ++
Sbjct: 251 SYNNYNDIFSALTISKSLPKN---SGTVIVKHANPCGVSIN-----------------KN 290
Query: 295 XXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKK 354
+S+FG V+ + + + A +++ + +IA G+ +ALK+L KKK
Sbjct: 291 SLKSYKLALASDPVSAFGGIVSCNFKINKTLALELNKIFLEVIIANGFQADALKILKKKK 350
Query: 355 GGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDL 414
N ++ L+ ++ L Q + + FK V +K + +++L
Sbjct: 351 --NIRIIDASEFMMKDLIRFGSVNESILTQSEDLKVFEPKDFK--VVSKLRPNKSQLKNL 406
Query: 415 IVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
I A +Y +SN++ A +GIG+GQ SR+ ++A
Sbjct: 407 IFAFNVCRYVKSNAIVLASQEATVGIGSGQPSRLDSCQIA 446
Score = 55.6 bits (128), Expect = 3e-06
Identities = 26/61 (42%), Positives = 36/61 (59%)
Query: 529 DKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFH 588
+ + ASDAFFPF D I++ VQ GV + PSGS D+E+I+ N+ L + R F
Sbjct: 458 EDIVAASDAFFPFVDGIEKLVQSGVSAVIQPSGSIRDKEIIKFANQTGTILVFSKTRHFR 517
Query: 589 H 589
H
Sbjct: 518 H 518
>UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=21; Epsilonproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Campylobacter jejuni
Length = 510
Score = 210 bits (512), Expect = 1e-52
Identities = 156/484 (32%), Positives = 240/484 (49%), Gaps = 49/484 (10%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSVSDK G++ K L G +++++GGT L+ G+ V +VSD T++PE+ GRVK
Sbjct: 3 ALLSVSDKEGIVEFGKELENLGFEILSTGGTFKLLKENGIKVIEVSDFTKSPELFEGRVK 62
Query: 66 TLHPAVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +H GIL + SD + + K + I +V NLYPF +T D + +ENID
Sbjct: 63 TLHPKIHGGILHKRSDENHIKQAKENEILGIDLVCVNLYPFKKTTIMSD-DFDEIIENID 121
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG ++R+AAKN+ V V+CDP DY+ V++ +K+ ++ + R L +KA+ HT++Y
Sbjct: 122 IGGPAMIRSAAKNYKDVMVLCDPLDYEKVIETLKKGQNDE---NFRLNLMIKAYEHTANY 178
Query: 185 DLAISDYFRKQYS---------PGQAQLTLRYGMNPHQKPA-QVFTTRDSLPITTLNGAP 234
D I++Y ++++ GQ +YG NPHQK A F S L G
Sbjct: 179 DAYIANYMNERFNGGFGASKFIVGQKVFDTKYGENPHQKGALYEFDAFFSANFKALKGEA 238
Query: 235 GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSX 294
F NL D A L +A PA A KH +P G A+ +E V L
Sbjct: 239 SFNNLTDINAALNLASSFDKA---PAIAIVKHGNPCGFAI------KENLVQSYIHALK- 288
Query: 295 XXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKK 354
+S++G VA++ D + A I+ + +IA +AL + KK
Sbjct: 289 ----------CDSVSAYGGVVAINGTLDEALANKINEIYVEVIIAANVDEKALAVFEGKK 338
Query: 355 GGNYCVLKIDPTYEPSLMEQ------KTIFGLTLEQKRNDAKITAELFKNV-VTTKKDLP 407
+KI P L+ K I G + Q N ++ + KN + ++++
Sbjct: 339 R-----IKIFTQESPFLIRSFDKYDFKHIDGGFVYQ--NSDEVGEDELKNAKLMSQREAS 391
Query: 408 SNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAALWWLRRHP 467
++DL +A +T+SN+V + ++G ++ IG G SRI + A KA L
Sbjct: 392 KEELKDLEIAMKIAAFTKSNNVVYVKNGAMVAIGMGMTSRIDAAKAAIAKAKEMGLDLQG 451
Query: 468 SVLA 471
VLA
Sbjct: 452 CVLA 455
Score = 62.5 bits (145), Expect = 3e-08
Identities = 30/57 (52%), Positives = 40/57 (70%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
LAS+AFFPFRD+ID A + GV+ I P GS D EV++A +E+ +AL T +R F H
Sbjct: 454 LASEAFFPFRDSIDEASKVGVKAIVEPGGSIRDDEVVKAADEYGMALYFTGVRHFLH 510
>UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Candidatus
Methanoregula boonei 6A8|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methanoregula
boonei (strain 6A8)
Length = 525
Score = 202 bits (493), Expect = 2e-50
Identities = 162/465 (34%), Positives = 233/465 (50%), Gaps = 50/465 (10%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSV DKTG++ LA++L + +++SGGT TAL AG+ +VS T PEM+ GRVK
Sbjct: 34 ALLSVWDKTGIVDLAQALIQHNFSIMSSGGTGTALAGAGIPFTEVSRYTGFPEMMDGRVK 93
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHP VH G+L R D M + I ++V NLYPF + +S+ + + +E ID+
Sbjct: 94 TLHPKVHGGLLGR-RQIDDAIMAKYGINRIGLLVVNLYPF-ERMSRESLPLEKLIEYIDV 151
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRL--ALKAFTHTSD 183
GG ++RAAAKN V VV DP+DY VVK + N QRL A KAF T+
Sbjct: 152 GGPAMIRAAAKNFKDVAVVVDPSDYPEVVKTLSSN----VGFSHEQRLIFAKKAFARTAA 207
Query: 184 YDLAISDYFRKQYSPGQAQLT--------LRYGMNPHQKPAQVFTTRDSLPITTLNGAP- 234
YD AIS++ + LT LRYG NPHQ+ A V+ T L G
Sbjct: 208 YDAAISNHLSNLDNTFPPILTLQFTNGRMLRYGENPHQQ-AAVYGTTGIAGAEPLQGKQM 266
Query: 235 GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSX 294
+ N D L+ E +E P A KH +P G +VG TD ++ LS
Sbjct: 267 SYNNYLDVNAGTALLAEFEE----PTAVIVKHNNPCGVSVG---TD------ILEAYLS- 312
Query: 295 XXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKK 354
+S++G V+L+ D A I + V AP ++ +A++ + KK+
Sbjct: 313 -------ARDVDPVSAYGSVVSLNREVDKKLAEAIDSTFVEVVAAPSFTRDAVEAMRKKE 365
Query: 355 GGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKN-VVTTKKDLPSNAVRD 413
+L T + E +TI G L Q+ T +N V T +D ++ +
Sbjct: 366 NMRVLILPERNTSD----EVRTIDGGVLVQR------TPAYQENWQVITDRDPTTDEMSA 415
Query: 414 LIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
L +A K+T+SN++ FA + +GIGAGQ SR+ ++A KA
Sbjct: 416 LRIAWKVCKHTKSNTIIFADQKRTLGIGAGQMSRVDSAKIAIEKA 460
Score = 55.2 bits (127), Expect = 5e-06
Identities = 25/58 (43%), Positives = 34/58 (58%)
Query: 532 ALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
A+ASDAF PF D ++ A + G + P GS D EVI+A N +A+ T +R F H
Sbjct: 468 AVASDAFLPFPDTLEVAAKAGATALVQPGGSIRDDEVIKAANRLNVAMVFTGVRYFRH 525
>UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Thermoplasmatales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Picrophilus torridus
Length = 494
Score = 198 bits (482), Expect = 4e-49
Identities = 151/462 (32%), Positives = 231/462 (50%), Gaps = 54/462 (11%)
Query: 7 LLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKT 66
L+SVSD +GL L + L+ + A+ GT L ++G+ + +SDIT ++L GRVKT
Sbjct: 4 LVSVSDTSGLTDLLRHLNG---DVYATPGTFKFLSDSGIKAKRISDITGFDDLLNGRVKT 60
Query: 67 LHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDIG 126
LHPAV +GIL+R + + D+KR Y +V+CNLY F + K ++ D +ENIDIG
Sbjct: 61 LHPAVFSGILSRRDEQSEADLKRYNYFDFDIVICNLYNFESYIDK---SIEDMIENIDIG 117
Query: 127 GVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDL 186
G++L+RAAAKN+ VTV P DY+ ++K++++ + +L TR+ LAL+AF + YD+
Sbjct: 118 GLSLIRAAAKNYQHVTVASSPEDYNIIIKDLRDG---EISLRTRETLALRAFARAAYYDM 174
Query: 187 AI---------SDYFRKQYSPGQAQLTLRYGMNPHQKPAQVFTTRDSLPI---TTLNGAP 234
I +D + + G + LRYG NP Q ++ T D I LNG
Sbjct: 175 IIYKSLYKRLNNDEPEELFIHGYDRTKLRYGENPDQ-AGFLYRTDDEYGIPNAVQLNGKE 233
Query: 235 -GFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELS 293
+ N+ DA +A + V E E P A KH +P+G + + D
Sbjct: 234 LSYNNIIDADSALETVLEFDE----PTAVIVKHRTPSGVSSADNIRD------------- 276
Query: 294 XXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKK 353
S++G +AL+ D TA +S+ + +IAP Y AL +L KK
Sbjct: 277 ----AFINAYSSDEESAYGFVLALNRKVDEETAMELSKHYIEVLIAPDYDEPALNILKKK 332
Query: 354 KGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQK-RNDAKITAELFKNVVTTKKDLPSNAVR 412
K N +LK S + Q GL ++ R+D F + + +
Sbjct: 333 K--NLRILKAVFRRNNSYVFQSIPGGLLMQSPLRSD-------FTEMKCMTIEADERTKK 383
Query: 413 DLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
DL+ A + +SN++ A++ GIGAGQ SRI R+A
Sbjct: 384 DLLFAWRVSAHCKSNAIVLAKNLTTTGIGAGQTSRIESLRIA 425
Score = 50.0 bits (114), Expect = 2e-04
Identities = 25/57 (43%), Positives = 34/57 (59%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASD F PF D+I A + G++ I P GS D +VI+ E+KI L T R+F H
Sbjct: 438 MASDGFIPFNDSIIEANKNGIKAIIEPGGSIRDNDVIQKAIEYKIPLYFTGKRVFLH 494
>UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=2; Tropheryma whipplei|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 542
Score = 196 bits (478), Expect = 1e-48
Identities = 153/489 (31%), Positives = 238/489 (48%), Gaps = 57/489 (11%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDK+GL LA++L+ ++++++G TA +R + V+DVS++T E+L GRVK
Sbjct: 10 ALISVSDKSGLADLAEALAAHSVKIVSTGSTAEFIRGVSIPVRDVSEVTGVGELLDGRVK 69
Query: 66 TLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +HA ILA S + +++ + +VV NLYPF + + +D +E ID
Sbjct: 70 TLHPKIHAPILADTTSQMHRAQLQQLGVDAFDLVVVNLYPFFEISKNSEAEFSDVIEQID 129
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG L+RAAAKNH RV V+ DP+DY V+ ++ + R +LA+KA++HTS+Y
Sbjct: 130 IGGSALIRAAAKNHTRVVVIVDPSDYIHVINSLERGAPSRL----RHQLAIKAYSHTSEY 185
Query: 185 DLAI----SDYFRKQ--YSP----------------------GQAQLTLRYGMNPHQKPA 216
DL I S+ F K YS G+ LRYG N HQK +
Sbjct: 186 DLHISRWLSERFYKHTLYSSSDSVGDVCDNNLDSNDHFVELRGKKLGDLRYGENSHQKAS 245
Query: 217 QVFTTRDSLPITTLNGAPGFINLCDALNAW---QLVKELKEALSLPAAASFKHVSPAGAA 273
+ ++S+P L A + N + + + + LP + KH +P G A
Sbjct: 246 LYLSCKESVPQLGLASAALLGGKQMSYNNYLDADVASRIVNSFDLPTVSFVKHGNPCGIA 305
Query: 274 VGLPLTDEEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREV 333
+ E A C A E S+FG VA++ + AT +
Sbjct: 306 SNI----EVAIACRNAHECDPT-------------SAFGGVVAVNREVTLDVATHLLPIF 348
Query: 334 SDGVIAPGYSPEALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITA 393
+ V+APGY P+AL+LL KKK L +Y + Q + L + + D T
Sbjct: 349 IEVVVAPGYDPQALQLLLKKKNLRVVELPECASYPQDQLRQISGGFLVQDADKFDHHDTF 408
Query: 394 ELFKNVVTTKKDLPSNA----VRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIH 449
+ V + + + A + DL A + + +SN++ A++ +GIG GQ +R+
Sbjct: 409 SSWTQVSGPRIFMDAGADNETLMDLEFAWKSCAFVKSNAILLAKNMASVGIGMGQVNRLD 468
Query: 450 CTRLAGGKA 458
LA +A
Sbjct: 469 ACYLAVNRA 477
Score = 48.8 bits (111), Expect = 4e-04
Identities = 24/56 (42%), Positives = 30/56 (53%)
Query: 534 ASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
ASDAFFPF D +D + GV+ I P GS D VI A + + + T R F H
Sbjct: 487 ASDAFFPFSDGLDVLINSGVKAIVQPGGSVRDNAVIAAAQQAGVTMFFTGKRHFAH 542
>UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio
bacteriovorus|Rep: IMP cyclohydrolase - Bdellovibrio
bacteriovorus
Length = 507
Score = 192 bits (469), Expect = 2e-47
Identities = 162/457 (35%), Positives = 226/457 (49%), Gaps = 46/457 (10%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSVSDKTGLL LAK+L+ ++LIASGGTA AL AGL V V ++ E GR+K
Sbjct: 7 ALLSVSDKTGLLELAKNLAAQNVELIASGGTAKALTEAGLKVTAVETLSGKGEAFNGRMK 66
Query: 66 TLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
T+ + + +L R D +D E I +VV NLYPF T+ K + +ENID
Sbjct: 67 TISFEIASSLLFRRQDENDVRQAAELGIEPIDLVVVNLYPFHATLQK-QAGFEECIENID 125
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG TLLRA AKN VTV+CDP+ Y +KE N + TT RQ+ A +T T+ Y
Sbjct: 126 IGGPTLLRAGAKNFHSVTVLCDPSQYSEFLKEFNGN-NGSTTWEFRQKCAAAVYTMTAFY 184
Query: 185 DLAISDYFRKQYSPGQAQLTLRYGMNPHQKPAQVFTT-RDSLP-ITTLNGAP-GFINLCD 241
D+AI+ + + + G A LRYG NPHQK + D L +L G + N D
Sbjct: 185 DMAIAGFLTQ--NSGAA---LRYGENPHQKAVVLKDPFADGLAHAKSLQGKEMSYNNYLD 239
Query: 242 ---ALNAWQLVKELKEALSLPAAASFKHVSPAGAAVG-LPLTDEEAAVCMVAGELSXXXX 297
AL Q V + +LPAA KH +P G AV PL E A
Sbjct: 240 ADFALKTLQDVHRWQGEKALPAAVVVKHNTPCGMAVAETPLRALEKA------------- 286
Query: 298 XXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGN 357
SSFG +AL+ P A + + + ++AP ++ A + L K N
Sbjct: 287 -----WKGDEKSSFGGIIALNVPVTEDIAAFFAEKFVEVILAPSFTEGAREKLKK----N 337
Query: 358 YCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVA 417
V+++ PS+ + GL L+ DA +L T+K + R A
Sbjct: 338 CRVMEVSLKPNPSMQVRSIEGGLLLQ----DAD-GFDLSHMKTVTQKQVSPEQQRLAAFA 392
Query: 418 TIALKYTQSNSVCFAR-DG---QVIGIGAGQQSRIHC 450
+A+K +SN++ R DG +++ +G+GQ +RI C
Sbjct: 393 MLAVKNLKSNAIALCRQDGPEFELLTMGSGQTNRIDC 429
Score = 53.2 bits (122), Expect = 2e-05
Identities = 29/75 (38%), Positives = 40/75 (53%)
Query: 515 LFTDSQREEWIKKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNE 574
L T ++ I + V LASDAFFPF D+I + + GV+ I P GS D EVI +
Sbjct: 433 LITSRLADKGITDLTGVVLASDAFFPFADSIQVSAKLGVQTIIQPGGSVKDPEVIAEADR 492
Query: 575 HKIALAHTNLRLFHH 589
+++ T R F H
Sbjct: 493 LGVSMIFTGRRHFLH 507
>UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=5; Bacteroides|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacteroides thetaiotaomicron
Length = 507
Score = 188 bits (459), Expect = 3e-46
Identities = 152/475 (32%), Positives = 242/475 (50%), Gaps = 39/475 (8%)
Query: 5 TALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRV 64
TAL+SV K GL + L E G++ +++GGT + + G + V D+T P +LGGRV
Sbjct: 9 TALVSVYHKEGLDEIITKLYEEGVEFLSTGGTRQFIESLGYPCKAVEDLTTYPSILGGRV 68
Query: 65 KTLHPAVHAGILARLSDSDQEDMKRQKYEM--ISVVVCNLYPFVQTVSKPDVTVADAVEN 122
KTLHP + GIL R D +Q+ + +KYE+ I +V+ +LYPF TV+ + AD +E
Sbjct: 69 KTLHPKIFGGILCR-RDLEQDIQQIEKYEIPEIDLVIVDLYPFEATVAS-GASEADIIEK 126
Query: 123 IDIGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTS 182
IDIGG++L+RAAAKN++ V +V A Y ++ + E+ ++L R+ +A +AF +S
Sbjct: 127 IDIGGISLIRAAAKNYNDVIIVASQAQYKPLLDMLMEH-GATSSLEERRWMAKEAFAVSS 185
Query: 183 DYDLAISDYFRKQYSPG-----QAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAP-GF 236
YD AI +YF Q LRYG NPHQK + D++ ++G +
Sbjct: 186 HYDSAIFNYFDAGEGSAFRCSVNNQKQLRYGENPHQK-GYFYGNLDAM-FDQIHGKEISY 243
Query: 237 INLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXX 296
NL D A L+ E ++ A KH + G A P T EA +AG+
Sbjct: 244 NNLLDINAAVDLIDEYEDL----TFAILKHNNACGLA-SRP-TVLEAWTDALAGD----- 292
Query: 297 XXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGG 356
+S+FG + + D + A I++ + +IAP Y +AL++L +KK
Sbjct: 293 ----------PVSAFGGVLITNGVIDKAAAEEINKIFFEVIIAPDYDVDALEILGQKK-- 340
Query: 357 NYCVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIV 416
N +L P + + G+ ++ K + + A+L VT K P V DL+
Sbjct: 341 NRIILVRKEAKLPKKQFRALLNGVLVQDKDMNIETVADL--RTVTDKAPTPEE-VEDLLF 397
Query: 417 ATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAALWWLRRHPSVLA 471
A +K ++SN++ A+ Q++ G GQ SR+ + A KA + + +V+A
Sbjct: 398 ANKIVKNSKSNAIVLAKGKQLLASGVGQTSRVDALKQAIEKAKSFGFDLNGAVMA 452
Score = 52.0 bits (119), Expect = 4e-05
Identities = 24/62 (38%), Positives = 35/62 (56%)
Query: 528 MDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLF 587
++ +ASDAFFPF D ++ A + G+ + P GS D CNEH +A+ T +R F
Sbjct: 446 LNGAVMASDAFFPFPDCVEIADKEGITAVIQPGGSVKDDLTFAYCNEHGMAMVTTGIRHF 505
Query: 588 HH 589
H
Sbjct: 506 KH 507
>UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=24;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 508
Score = 188 bits (458), Expect = 4e-46
Identities = 152/473 (32%), Positives = 232/473 (49%), Gaps = 37/473 (7%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SV K GL + L+ G++ +++GGT + + G + V D+TR P MLGGRVK
Sbjct: 11 ALISVYHKEGLAEILAELNRQGVEFVSTGGTHEFITSLGYACRAVDDLTRYPSMLGGRVK 70
Query: 66 TLHPAVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP + GILAR +SD ++ +I +V+ +LYPF TV+ + D +E ID
Sbjct: 71 TLHPMIFGGILARRGHESDVREVGEYGLPLIDLVIVDLYPFEATVAS-GASEEDIIEKID 129
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG++L+R AAKN + V ++ A Y +KE + +T+L R+ A +AF +S Y
Sbjct: 130 IGGISLIRGAAKNFEDVVIISSRAQYAGFYSLLKE-QGARTSLAERRHYAREAFAVSSAY 188
Query: 185 DLAISDYF--RKQYS---PGQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAP-GFIN 238
D AI YF +Q + + LRYG NPHQ+ F D L G + N
Sbjct: 189 DSAIFRYFDDGEQTAFRMSADSPKVLRYGENPHQR-GFFFGNFDRY-FDKLQGKEISYNN 246
Query: 239 LCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXXX 298
L D A L+ E S P A KH + G A L EA +AG+
Sbjct: 247 LQDIEAAVSLISE----FSAPTFAILKHTNACGIASRGTLI--EAWQAALAGD------- 293
Query: 299 XXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNY 358
+S+FG + + P D TA I + + +IAP Y A++ L++K
Sbjct: 294 --------PVSAFGGILVTNTPIDRETAQEIDKIFFEVIIAPDYDNAAMEYLTRKT-NRI 344
Query: 359 CVLKIDPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVAT 418
+L+ +P E + +++FG L Q+ + FK V T ++ DLI A
Sbjct: 345 ILLQKEPVREQ--WQFRSMFGGVLMQQVDGVTAKTVDFKPV--TPVVPTADETDDLIFAN 400
Query: 419 IALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAALWWLRRHPSVLA 471
+K+++SN++ +D Q+ G GQ SR+ R A KA + + +V+A
Sbjct: 401 KVVKHSKSNAITLVKDSQLCASGVGQTSRVDALRQAIDKARNFGFDLNGAVMA 453
Score = 49.6 bits (113), Expect = 2e-04
Identities = 24/62 (38%), Positives = 34/62 (54%)
Query: 528 MDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLF 587
++ +ASDAFFPF D ++ A + G+ I P GS D IE + IA+ T +R F
Sbjct: 447 LNGAVMASDAFFPFADCVEIAAEAGIRAIIQPGGSIKDNLSIEEATKKGIAMVMTGVRHF 506
Query: 588 HH 589
H
Sbjct: 507 KH 508
>UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrolase;
n=2; Dictyostelium discoideum|Rep: AICAR transformylase
/ IMP cyclohydrolase - Dictyostelium discoideum AX4
Length = 542
Score = 186 bits (453), Expect = 1e-45
Identities = 97/195 (49%), Positives = 129/195 (66%), Gaps = 6/195 (3%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSV +K+G++ +K LS G LI++GGTA +L + GL VQ VSD+T PEML GRVK
Sbjct: 3 ALLSVYNKSGIVEFSKILSSKGFNLISTGGTAKSLVDNGLKVQQVSDVTEYPEMLDGRVK 62
Query: 66 TLHPAVHAGILARLS-DSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +H G+LAR Q D+ + + IS+VV NLYPFV+TVSK T+ +A+ENID
Sbjct: 63 TLHPKIHGGLLARPELAHHQADLNKYNIKPISIVVVNLYPFVETVSKESTTLEEAIENID 122
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKE-----NKHHQTTLGTRQRLALKAFT 179
IGG TL+RA++KN V ++ DP+DY + + I+ N TL R++LALKAF
Sbjct: 123 IGGHTLIRASSKNFQNVLIIVDPSDYKWIGERIQSSTDSTNVLSSITLEERKKLALKAFQ 182
Query: 180 HTSDYDLAISDYFRK 194
H YD A+S Y K
Sbjct: 183 HGCSYDAAVSQYLSK 197
Score = 71.3 bits (167), Expect = 7e-11
Identities = 78/266 (29%), Positives = 116/266 (43%), Gaps = 33/266 (12%)
Query: 205 LRYGMNPHQKPA--QVFTTRDSLPITTLNG-APGFINLCDALNAWQLVKELKEALSLPAA 261
LRYG NPHQK A Q T L+G A + N+ D A + V+E A
Sbjct: 235 LRYGENPHQKAALYQCPGTGGIANAQLLHGPALSYNNILDGDAALKAVREFDRC----AC 290
Query: 262 ASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPC 321
KH +P G +VG+ E+A V A S++G + +
Sbjct: 291 VVIKHTNPCGLSVGVN-DSEQAEVYKRA-------------FNGDPKSAYGGILGFNRTL 336
Query: 322 DVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKIDPTYEPSLMEQ---KTIF 378
+ TAT + + +IAP Y+ +AL LLSKK+ +L+I Q +TI
Sbjct: 337 TLETATALKSVFYEVIIAPDYTEDALALLSKKE--KLRILRIPEAANQIQFTQPDIRTIT 394
Query: 379 GLTLEQKRNDA--KITAELFKN-VVTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDG 435
G L Q N AE KN V T+ ++DL+ A K+ +SN++ ++D
Sbjct: 395 GGALLQSPNPIIRGDLAEATKNWKVVTENKPTEQQMKDLLFAWRVSKHVKSNAIVLSKDE 454
Query: 436 QVIGIGAGQQSRIH----CTRLAGGK 457
++ IGAGQ +R C ++ G K
Sbjct: 455 TIVAIGAGQPNRSQSVDICMKVGGDK 480
Score = 58.8 bits (136), Expect = 4e-07
Identities = 31/63 (49%), Positives = 38/63 (60%)
Query: 527 KMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRL 586
K+ LASDAFFPF D+ID A Q + I P GS DQEVI+A N++ I + T R
Sbjct: 480 KVKGSVLASDAFFPFADSIDLAHQGNIACIVQPGGSIRDQEVIDAANKYGIPMVFTGNRN 539
Query: 587 FHH 589
F H
Sbjct: 540 FLH 542
>UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacterium
nodosum Rt17-B1|Rep: IMP cyclohydrolase -
Fervidobacterium nodosum Rt17-B1
Length = 429
Score = 180 bits (439), Expect = 7e-44
Identities = 102/208 (49%), Positives = 132/208 (63%), Gaps = 5/208 (2%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDK GL+ AK+L + G+++I++GGTA L +AG+ V+ VSD+T PE+LGGRVK
Sbjct: 6 ALISVSDKAGLVEFAKNLVDRGVEIISTGGTAKLLSDAGIPVKQVSDVTGFPEILGGRVK 65
Query: 66 TLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP + GILA L D S +D++ E I +VV NLYPF V K +ENID
Sbjct: 66 TLHPKIFGGILADLGDKSHVKDLRDNFIEPIDLVVVNLYPF-DEVQKKTRDEDVLIENID 124
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGGV LLRAAAKNH V VVCDPADYD V+K I + L R+ ALKAF HT Y
Sbjct: 125 IGGVALLRAAAKNHRNVVVVCDPADYDKVIKSI--DLCGDVQLHDRRMFALKAFYHTMKY 182
Query: 185 DLAISDYFRKQYSPGQAQ-LTLRYGMNP 211
D I + ++ + + +T +NP
Sbjct: 183 DATIHRVLSELFASEKFEHMTFERFINP 210
>UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=89; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bifidobacterium longum
Length = 545
Score = 179 bits (436), Expect = 2e-43
Identities = 146/475 (30%), Positives = 229/475 (48%), Gaps = 33/475 (6%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SV K G+ LA++ + G +++++G TA L G+ V +VSD+T PE L GRVK
Sbjct: 11 ALVSVFHKEGIEVLAEAFVKAGTEVVSTGSTAKKLAELGVKVTEVSDVTGFPECLDGRVK 70
Query: 66 TLHPAVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +HAGILA +++ + + ++ + +VV NLYPF TV + AD +E ID
Sbjct: 71 TLHPYIHAGILADMTNPEHAKQLEEFGIKPFDLVVVNLYPFADTV-RSGANEADTIEKID 129
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG +++R AAKNH V +V DPADY V + + +L R+ LA KAF HT+ Y
Sbjct: 130 IGGPSMVRGAAKNHATVAIVTDPADYALVASRVADGTGF--SLDERKWLAAKAFAHTAAY 187
Query: 185 DLAISDYFRKQYSPGQAQLTL--------RYGMNPHQKPAQVFTTRDSLPITTL--NGAP 234
D I+++ K + P A L ++P + PAQ T D N
Sbjct: 188 DATINEWTAKHW-PKPASLDAVEVDKDDQGTEVDPAKFPAQFTRTWDRAHTLRYGENSHQ 246
Query: 235 GFINLCDALN------AWQL-VKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCM 287
D LN A QL K + + A A+++ V A+ + + +
Sbjct: 247 QAALYIDPLNQTGFAHAEQLGGKPMSYNNYVDADAAWRTVWDMAPAIAVAVVKHNNPCGL 306
Query: 288 VAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEAL 347
G + MS++G +A + + A + ++ ++AP Y P AL
Sbjct: 307 AIG--ATAAEAHKKAHACDPMSAYGGVIACNSKVTLEMAESVRPIFTEVIVAPDYEPAAL 364
Query: 348 KLLSKKKGGNYCVLKI-DPTYEPSLMEQKTIFGLTLEQKR---NDAKITAELFKNVVTTK 403
+LL KK N +L++ +P + Q I G L Q N + +K V
Sbjct: 365 ELLQTKK-KNLRILEVAEPPKGHEAIRQ--IDGGLLVQDTDLINAVGDDPDAWKLVAGEA 421
Query: 404 KDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
D ++ ++DL+ A A++ +SN++ A D +GIG GQ +R+ LA +A
Sbjct: 422 AD--ADTLKDLVFAWRAIRCVKSNAILLAHDQATVGIGMGQVNRVDSCHLAVERA 474
Score = 50.8 bits (116), Expect = 1e-04
Identities = 25/56 (44%), Positives = 31/56 (55%)
Query: 534 ASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
ASDAFFPF D + GV+ I P GS D+EVIEA + + + T R F H
Sbjct: 490 ASDAFFPFADGAQVLIDAGVKAIVQPGGSIRDEEVIEAAKKAGVTMYLTGTRHFFH 545
>UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Buchnera aphidicola (Baizongia
pistaciae)|Rep: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Buchnera aphidicola subsp.
Baizongia pistaciae
Length = 529
Score = 167 bits (405), Expect = 1e-39
Identities = 137/478 (28%), Positives = 227/478 (47%), Gaps = 53/478 (11%)
Query: 7 LLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKT 66
L+SVSD + ++ +KSL ++L A+ GTA L+ + D+++ T PE++ GR+KT
Sbjct: 11 LISVSDTSNIIEFSKSLISKNIKLFATKGTANFLKKNNIYATDITNYTNFPEIMNGRIKT 70
Query: 67 LHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDIG 126
LH ++A ILA+ D++ +++ ++ +VV N YPF + + ++ + D +E+IDIG
Sbjct: 71 LHHKIYASILAQ-PKHDKKTIEKYNIILMDIVVINFYPFEEASNNTNLHLNDIIEHIDIG 129
Query: 127 GVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDL 186
G ++RAAAKN+ V VV P Y ++V E+ N ++ + T+ + A AF HT +YD
Sbjct: 130 GPAIVRAAAKNYKNVLVVTQPNLYQSIVNEMNLN-NNIISETTKLKFATIAFKHTMNYDN 188
Query: 187 AISDYFRKQYS--PGQAQL----------------TLRYGMNPHQKPAQVFTTRDS---- 224
I Y K+ P QL L YG N Q+ + T +
Sbjct: 189 NIYQYLSKKNKTVPKNTQLQTLLPSHLTINFKKKQDLCYGENKQQQASWYTNTSKNTSGR 248
Query: 225 LPITTLNG-APGFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEA 283
+ I L G + NL D A + E + A KH +P G A D+
Sbjct: 249 MKIKQLQGKILSYNNLSDIHLALSCIHEFNKT----TCAIIKHGNPCGVATA-KNNDQAY 303
Query: 284 AVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDPC-DVSTATIISREVSDGVIAPGY 342
+ +S +FG + + DV+ II + S+ ++AP +
Sbjct: 304 KLAYETDPIS----------------AFGGIIVFNQKLNDVTARKIIKTQFSEIILAPDF 347
Query: 343 SPEALKLLSKKKGGNYCVLKIDPTYE--PSLMEQKTIFGLTLEQKRNDAKITAELFKNVV 400
+ EA K+ KK N ++K DP Y ++ K+I+G L Q ++ I + +
Sbjct: 348 TQEAKKIFDKKP--NLRIIKYDPNYNYLNYNIDIKSIYGDILVQSNTNSIININQWD--I 403
Query: 401 TTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
+KK + D A +K+ +SNS+ ++ I IG+GQ SRI T++A KA
Sbjct: 404 VSKKRPNEQEINDAKFALRVVKHLKSNSIVLIKNQITISIGSGQTSRIDATKIAIYKA 461
Score = 57.2 bits (132), Expect = 1e-06
Identities = 26/62 (41%), Positives = 37/62 (59%)
Query: 528 MDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLF 587
++ LASDAFFPF D+ID + G+ I P GS D E+I + N++ I++ T R F
Sbjct: 468 LNHTTLASDAFFPFSDSIDLISKSGITCIVQPGGSIRDNEIIMSANKYNISMIFTKQRYF 527
Query: 588 HH 589
H
Sbjct: 528 KH 529
>UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1;
uncultured Acidobacteria bacterium|Rep: Putative AICAR
transformylase - uncultured Acidobacteria bacterium
Length = 571
Score = 165 bits (400), Expect = 4e-39
Identities = 82/187 (43%), Positives = 123/187 (65%), Gaps = 2/187 (1%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDKTG++ A L ++++++GGTA LR AG+ V+DVSD+T PEM+ GRVK
Sbjct: 15 ALISVSDKTGIVDFASELRAFDIEIVSTGGTAKTLREAGIEVRDVSDVTGFPEMMDGRVK 74
Query: 66 TLHPAVHAGIL-ARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +H G+L R S S + M+ E I +VV +LYPF +T+ V++A+A+E ID
Sbjct: 75 TLHPKIHGGLLGVRDSPSHESSMREHGIEPIDMVVIDLYPFERTIKGAAVSLAEAIEQID 134
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG ++R+AAKN V V+ + ++Y + +E++ + +L TR+RLA AF T+ Y
Sbjct: 135 IGGPAMIRSAAKNFHSVAVITNTSEYGPIAEELRAH-DCSLSLHTRRRLAEIAFQRTAQY 193
Query: 185 DLAISDY 191
D + Y
Sbjct: 194 DSIVFGY 200
Score = 86.2 bits (204), Expect = 2e-15
Identities = 81/260 (31%), Positives = 118/260 (45%), Gaps = 28/260 (10%)
Query: 204 TLRYGMNPHQKPAQVFTTRDS--LPITTLNGAP-GFINLCDALNAWQLVKELKEALSLPA 260
+LRYG NPHQ T S L+G F N DA AW LV + E A
Sbjct: 274 SLRYGENPHQIAGLYKTAAQSGIANAELLSGKEMSFNNYVDADAAWHLVCDFDEL----A 329
Query: 261 AASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVALSDP 320
A KH + AG A L E+A +A + + S+FG VA +
Sbjct: 330 CAIIKHTNAAGVA--LDKNAEDAYRKALATDPT---------------SAFGGIVAFNSR 372
Query: 321 CDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTIFGL 380
D S A + ++ V+A Y AL +L KK N VL+ +E + I G
Sbjct: 373 VDQSAALAVVEIFTEVVVATDYEEAALDVLRSKK--NLRVLRAARLTRAKGVEYRQISGG 430
Query: 381 TLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGI 440
L Q + ++ N+VT K++ + + DL+ A K+T+SN++ +ARD Q +G+
Sbjct: 431 MLVQTSDTHRLDKNDL-NIVT-KREPTESEISDLLFAWTVCKHTKSNAIVYARDKQTVGV 488
Query: 441 GAGQQSRIHCTRLAGGKAAL 460
GAGQ SR+ +L +A L
Sbjct: 489 GAGQMSRVDSVKLGAMRAQL 508
Score = 61.3 bits (142), Expect = 7e-08
Identities = 28/57 (49%), Positives = 36/57 (63%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
LASDAFFPFRD +D A + G+ + P GS D EVI A +E +A+ T +R F H
Sbjct: 515 LASDAFFPFRDGLDEAAKNGITAVIQPGGSMRDAEVIAAADEQGLAMVFTGIRHFKH 571
>UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 614
Score = 156 bits (379), Expect = 1e-36
Identities = 87/208 (41%), Positives = 124/208 (59%), Gaps = 5/208 (2%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SV DKTGL LA++L E G++++++G TA + AG+ V V D+T PE+L GRVK
Sbjct: 19 ALISVYDKTGLEDLARALGEAGVEIVSTGSTAARIAAAGVAVTPVDDVTGFPEVLEGRVK 78
Query: 66 TLHPAVHAGILA-RLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +H+GILA + + +E + + + +VVCNLYPF TV+ + + VE ID
Sbjct: 79 TLHPFIHSGILADQRKAAHREQIAQLGIQAFDLVVCNLYPFQDTVAS-GASFDECVEQID 137
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG +++RAAAKNH V VV P Y V + + TL R+ LA +AF HT+ Y
Sbjct: 138 IGGPSMVRAAAKNHPSVAVVTSPERYADVAEAVAGEGF---TLEQRRVLAAEAFAHTATY 194
Query: 185 DLAISDYFRKQYSPGQAQLTLRYGMNPH 212
DLAI+ + + + TL H
Sbjct: 195 DLAIAGWLADELDLEDVRETLDDAAETH 222
Score = 68.5 bits (160), Expect = 5e-10
Identities = 48/152 (31%), Positives = 78/152 (51%), Gaps = 4/152 (2%)
Query: 308 MSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKIDPTY 367
+S+FG +A++ P V A I ++ V+AP Y ALK+LS KK N VL+++P
Sbjct: 369 VSAFGGVIAVNRPVSVELARQIVPIFTEVVLAPDYEEGALKVLSAKK--NLRVLQVEPPA 426
Query: 368 EPSLMEQKTIFGLTLEQKRNDAKITAELFKN-VVTTKKDLPSNAVRDLIVATIALKYTQS 426
S E K I G L Q+R+D + +N + + DL A ++ +S
Sbjct: 427 RGS-YEFKQISGGLLVQERDDIDAPGDSPENWTLAAGAPADEATLADLEFAWRTVRAVRS 485
Query: 427 NSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
N++ +DG +G+G GQ +R+ +LA +A
Sbjct: 486 NAILLVKDGASVGVGMGQVNRVDSCKLAVERA 517
Score = 50.8 bits (116), Expect = 1e-04
Identities = 25/56 (44%), Positives = 31/56 (55%)
Query: 534 ASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
ASDAFFPF D + + GV+ + P GS DQE I+A N I + T R F H
Sbjct: 559 ASDAFFPFADGLQVLIDAGVKAVVQPGGSVRDQESIDAANAAGITMYLTGTRHFAH 614
>UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain; n=2; Candidatus Blochmannia|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain - Blochmannia floridanus
Length = 549
Score = 155 bits (377), Expect = 2e-36
Identities = 85/208 (40%), Positives = 122/208 (58%), Gaps = 4/208 (1%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SV DK+ LL +KSLS G++L+++ GTA L NAGLTV +SD T PE++ G+VK
Sbjct: 10 ALISVFDKSNLLHFSKSLSHLGIKLLSTEGTALILTNAGLTVNKISDYTNFPEIMNGQVK 69
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLH + AGIL+R + D+ + + + I +V+ N YPF + +E IDI
Sbjct: 70 TLHHKICAGILSR-KNLDESIIHKYGIQPIDMVIVNFYPFHLILQNKQHDSEKILEYIDI 128
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GG ++RAAAKN+ ++ D DYD ++ EI H +L TR LA KAF + YD
Sbjct: 129 GGPNMVRAAAKNYKNTVIIVDNNDYDNILNEI-NTLHGSISLNTRLNLAAKAFKYIKQYD 187
Query: 186 LAISDYFRKQ--YSPGQAQLTLRYGMNP 211
ISDYF+ Q P + T++ + P
Sbjct: 188 TMISDYFQHQLKLQPNKPHHTIQKRIQP 215
Score = 62.1 bits (144), Expect = 4e-08
Identities = 27/58 (46%), Positives = 37/58 (63%)
Query: 532 ALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
++ASDAFFPF D+I A G+ I P GS D E+I+ N+HKI++ T +R F H
Sbjct: 492 SMASDAFFPFPDSIKEAASMGISCIIQPGGSIQDPEIIKIANQHKISMIFTKIRHFRH 549
Score = 46.4 bits (105), Expect = 0.002
Identities = 40/154 (25%), Positives = 71/154 (46%), Gaps = 12/154 (7%)
Query: 309 SSFGDFVALSDPCDVS--TATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKIDPT 366
S+FG +A + P + +II++ + +IAP + L +LS+KK N VL+
Sbjct: 328 SAFGGIIAFNYPINNKKLAQSIINQNFVEAIIAPYVHQDCLNILSQKK--NIRVLQSGMW 385
Query: 367 YEPSLMEQKTIF------GLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVATIA 420
+ +L I GL +++ + F+ V T K +D +
Sbjct: 386 NKNTLKSISNIDFKRIPEGLLIQEHDTHTIDHTKSFQ--VVTNKQPTIQETQDALFCWKI 443
Query: 421 LKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLA 454
+K+ +SN++ +D Q GIG GQ +RI ++A
Sbjct: 444 VKFVKSNAIVCGKDQQTTGIGTGQTNRILAVKIA 477
>UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Desulfovibrionaceae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Desulfovibrio desulfuricans (strain
G20)
Length = 252
Score = 150 bits (363), Expect = 1e-34
Identities = 80/187 (42%), Positives = 116/187 (62%), Gaps = 3/187 (1%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
ALLSV+DK+GL+ A L++ G++L+++GGT L AGL V VS +T PE++GGRVK
Sbjct: 62 ALLSVTDKSGLVEFATFLTQNGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRVK 121
Query: 66 TLHPAVHAGILARLSDSDQ-EDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
TLHP +H GILA + + +K ++ NLY F ++ + + AVE +D
Sbjct: 122 TLHPHIHGGILADKDNPEHLATLKELGIRTFDLICVNLYNFADAAAR-GLDLRGAVEEVD 180
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG +LRA AKN + V+ DPADY A ++E+++N + L RQ +A+K F TS Y
Sbjct: 181 IGGPCMLRATAKNFHSMLVLPDPADYQAAMQEMRDN-DMRVGLAMRQAMAVKTFRATSAY 239
Query: 185 DLAISDY 191
D I+DY
Sbjct: 240 DGMIADY 246
>UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: IMP cyclohydrolase -
Candidatus Desulfococcus oleovorans Hxd3
Length = 225
Score = 145 bits (352), Expect = 3e-33
Identities = 89/197 (45%), Positives = 115/197 (58%), Gaps = 9/197 (4%)
Query: 7 LLSVSDKTGLLSLAKSLSECG--LQLIASGGTATALRN-----AGLTVQDVSDITRAPEM 59
L+SVSDKTGL L + + ++GGT + A + VSD T PE
Sbjct: 19 LISVSDKTGLEEFVTRLVRINPDVHIFSTGGTYQKIYEIFGSAAKSVLTQVSDYTGQPET 78
Query: 60 LGGRVKTLHPAVHAGILARL-SDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVAD 118
GG VKTL ++ G+L ++S DMKR I +VV NLYPF QTV++PDVT
Sbjct: 79 QGGLVKTLDFKIYLGLLTETYNESHARDMKRTGAVAIDMVVVNLYPFSQTVARPDVTPEQ 138
Query: 119 AVENIDIGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAF 178
A NIDIGG ++RA+AKN RV V DPADY+ V E+ E++ +L TR LA KAF
Sbjct: 139 ARGNIDIGGPCMVRASAKNFLRVASVVDPADYNTVADEM-EHRQGALSLDTRFELAQKAF 197
Query: 179 THTSDYDLAISDYFRKQ 195
HT+ YD AI+DY +KQ
Sbjct: 198 DHTAAYDRAIADYLKKQ 214
>UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Gammaproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Wigglesworthia glossinidia
brevipalpis
Length = 529
Score = 141 bits (341), Expect = 5e-32
Identities = 76/191 (39%), Positives = 114/191 (59%), Gaps = 3/191 (1%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+SVSDKTG+ SLAK+L + ++LI + GT L G+ VS+ PE++ GRVK
Sbjct: 11 ALISVSDKTGIFSLAKNLIKHKVKLITTSGTYKYLLEKGIFSTSVSEYINHPEIINGRVK 70
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TLHP +H GIL+ ++ + + K + I +V+ N YPF + V K ++ + + ++NIDI
Sbjct: 71 TLHPKIHGGILS--NNKNINENKNLNIKKIDMVITNFYPFKKKVKKENIKIENIIDNIDI 128
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYD 185
GGV L R+AAKN+ VTVV + Y + E+ +N + TR + AF ++ YD
Sbjct: 129 GGVALARSAAKNYKYVTVVVNINQYSKLSSEMDKNS-GSVSFKTRFYFSTLAFQYSYSYD 187
Query: 186 LAISDYFRKQY 196
I +YF K Y
Sbjct: 188 KEIFNYFNKIY 198
Score = 62.5 bits (145), Expect = 3e-08
Identities = 29/57 (50%), Positives = 39/57 (68%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASDAFFPFRD+ID A + GV I P GS ND ++I A +E+ +++ TN R F H
Sbjct: 473 MASDAFFPFRDSIDFASKFGVSCIIQPGGSINDDKIISAVDENNMSMIFTNTRQFSH 529
Score = 58.4 bits (135), Expect = 5e-07
Identities = 46/153 (30%), Positives = 78/153 (50%), Gaps = 9/153 (5%)
Query: 309 SSFGDFVALSDPCDVSTAT-IISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKIDPTY 367
S+FG ++ + P + A II+++ + +IAP +AL L K VL+
Sbjct: 315 SAFGGIISFNRPLTIEAAEFIINKQFVEIIIAPVIEKDALLTLKSKS--KIIVLECGYLS 372
Query: 368 EPSLMEQKTI-FGLTLEQKRNDAKITAELFKNVVTTKKDLPSNA-VRDLIVATIALKYTQ 425
+ L+ K + GL L+ +D KI E K++ K PS + I +K+ +
Sbjct: 373 KNFLLNFKKVNCGLLLQD--SDNKILKE--KDIKIVSKRQPSKLEIESSIFIWKIIKFIK 428
Query: 426 SNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKA 458
SN++ + ++ + +GIG+GQ SRI TR+A KA
Sbjct: 429 SNAIIYGKNKRTLGIGSGQTSRIFSTRIAAYKA 461
>UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=4; Thermotogaceae|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Thermotoga maritima
Length = 452
Score = 137 bits (332), Expect = 7e-31
Identities = 148/458 (32%), Positives = 212/458 (46%), Gaps = 77/458 (16%)
Query: 7 LLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKT 66
L+S+ +K L + + L E G ++ AS GTA L++ G+ DVS IT +LGG VKT
Sbjct: 5 LVSLYEKEKYLDILRELHEKGWEIWASSGTAKFLKSNGIEANDVSTITGFENLLGGLVKT 64
Query: 67 LHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDIG 126
LHP + AGIL D VV +LYP PD IDIG
Sbjct: 65 LHPEIFAGILGPEPRWD-------------VVFVDLYP------PPD---------IDIG 96
Query: 127 GVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDL 186
GV LLRAAAKN +V D + EI + + TR+ LA F TS YD
Sbjct: 97 GVALLRAAAKNWKKVKPAFDMETLKLAI-EIDDEE-------TRKYLAGMTFAFTSVYDS 148
Query: 187 AISDYFRKQYSPG--QAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPGFINLCDALN 244
++ F + S + L LRYG NPH+K A V+ + + I F N+ DA N
Sbjct: 149 IRANQFVEGISLAFKREDLQLRYGENPHEK-AFVY-GKPAFEILHEGKTISFNNILDAEN 206
Query: 245 AWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXXXXXXXXX 304
AW + K L A KH SP GAA+G +++ + A E
Sbjct: 207 AWFMAKNLPRM----GAVVVKHQSPCGAAIG----EDKVEIVKKAIEADDE--------- 249
Query: 305 XXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKID 364
SSFG +A++ D A + + + + ++AP ++ EA+++LSKKK V +
Sbjct: 250 ----SSFGGILAVNFEMDEEVAKSLKKYL-EVIVAPSFTQEAIEVLSKKK-----VRLLK 299
Query: 365 PTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVATIALKYT 424
P + + K FG + +R + EL ++K+L DL A ++
Sbjct: 300 PG-DYASWAGKMAFGSLVLSERKYPEGNFELVVGEPLSEKEL-----EDLEFAYRVVEGA 353
Query: 425 QSNSVCFARDGQVIGIGAGQQSRIH----CTRLAGGKA 458
+SN+V A+DG +GIG+GQ SR T +AG KA
Sbjct: 354 KSNAVLIAKDGVTVGIGSGQPSRKRAAWIATVMAGEKA 391
Score = 51.6 bits (118), Expect = 6e-05
Identities = 26/64 (40%), Positives = 35/64 (54%)
Query: 526 KKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLR 585
+K ASDAFFPF D+++ Q GV+ + +P GS D+EVIE E I R
Sbjct: 389 EKAKGAVAASDAFFPFPDSLEILAQAGVKAVVAPLGSIRDEEVIEKARELGITFYKAPSR 448
Query: 586 LFHH 589
+F H
Sbjct: 449 VFRH 452
>UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Petrotoga mobilis SJ95|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Petrotoga mobilis SJ95
Length = 489
Score = 131 bits (317), Expect = 4e-29
Identities = 81/217 (37%), Positives = 120/217 (55%), Gaps = 11/217 (5%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
A++SV DKT L LA L G+++I + GT L+ G+ ++D PE+LGGRVK
Sbjct: 6 AIISVYDKTNLEDLASFLYRNGVEIICTEGTNKYLQEKGIPTVKMADYIGFPEILGGRVK 65
Query: 66 TLHPAVHAGILARLSD-SDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENID 124
++ P + GILA+ +D +EDM + I +VV N +P + ++K +ENID
Sbjct: 66 SIDPKLAGGILAKSNDKKHEEDMINYNIKRIDMVVGN-FPTFEEIAKKTKNEETLLENID 124
Query: 125 IGGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDY 184
IGG +LLRAAAKN+ V + DP DY V+ +++ L R++LALK F TS Y
Sbjct: 125 IGGYSLLRAAAKNYKDVVALADPKDYQTVIDNLED--CGDVPLQLRRKLALKVFFSTSKY 182
Query: 185 DLAISDYFRKQYSPGQAQL-------TLRYGMNPHQK 214
D +I F + ++ + LRYG NP Q+
Sbjct: 183 DASIHKIFSELFAAEKFDHEFFEILGNLRYGSNPMQE 219
>UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Salinispora arenicola
CNS205|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Salinispora arenicola CNS205
Length = 190
Score = 111 bits (266), Expect = 7e-23
Identities = 71/186 (38%), Positives = 103/186 (55%), Gaps = 9/186 (4%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
A+L+VSDK + LA L G ++A+ GT LR+ G+TV VSD+ P +LGGRVK
Sbjct: 3 AVLAVSDKRNIEELATGLLGLGWDVVATEGTRRLLRDHGVTVGAVSDLAGVPTLLGGRVK 62
Query: 66 TLHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDI 125
TL ++ GILAR +D+ +++R + +V CN Y +P E ID+
Sbjct: 63 TLTVSLMGGILARDEPADRAEVERHGLTRVHLVCCNYYRLPD--PQPAQPFERFRELIDV 120
Query: 126 GGVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQR--LALKAFTHTSD 183
GG +LRAAAKN V + DP DY V+K + + + RQR LA KAF ++
Sbjct: 121 GGPAMLRAAAKNCAHVVPLSDPDDYAGVLKALADG-----GVDRRQRLDLARKAFAVSAA 175
Query: 184 YDLAIS 189
YD +++
Sbjct: 176 YDTSVA 181
>UniRef50_Q6PWM1 Cluster: 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase;
n=2; Laurasiatheria|Rep: 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase -
Bos taurus (Bovine)
Length = 81
Score = 103 bits (246), Expect = 2e-20
Identities = 48/80 (60%), Positives = 64/80 (80%), Gaps = 1/80 (1%)
Query: 507 LFEGKPPALFTDSQREEWIKKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQ 566
LFE + P L T+++++EWI K+++V+++SDAFFPFRDN+DRA + GV YI +PSGS D+
Sbjct: 3 LFE-EVPELLTETEKKEWIDKLNEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADK 61
Query: 567 EVIEACNEHKIALAHTNLRL 586
VIEAC E I LAHTNLRL
Sbjct: 62 VVIEACGELGIILAHTNLRL 81
>UniRef50_A5N885 Cluster: Conserved protein; n=1; Clostridium
kluyveri DSM 555|Rep: Conserved protein - Clostridium
kluyveri DSM 555
Length = 90
Score = 95.5 bits (227), Expect = 4e-18
Identities = 42/91 (46%), Positives = 61/91 (67%), Gaps = 1/91 (1%)
Query: 499 LPLEQWDTLFEGKPPALFTDSQREEWIKKMDKVALASDAFFPFRDNIDRAVQCGVEYIGS 558
+ +++W+ + K P T ++ W+ + V LASDAFFPFRDNI+RA Q GV+YI
Sbjct: 1 MEIKEWNKVLN-KIPNRLTKEEKTSWLFNLSGVCLASDAFFPFRDNINRASQSGVKYIVQ 59
Query: 559 PSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
P GS D VI+ACN++ + +A +N+RLFHH
Sbjct: 60 PGGSLRDDIVIDACNKYNMVMAFSNIRLFHH 90
>UniRef50_Q9HS43 Cluster:
Phosphoribosylaminoimidazole-succinocarboxamide
formyltransferase; n=5; Halobacteriaceae|Rep:
Phosphoribosylaminoimidazole-succinocarboxamide
formyltransferase - Halobacterium salinarium
(Halobacterium halobium)
Length = 595
Score = 92.7 bits (220), Expect = 2e-17
Identities = 80/262 (30%), Positives = 117/262 (44%), Gaps = 32/262 (12%)
Query: 205 LRYGMNPHQKPA----QVFTTRDSLPITTLNG---APGFINLCDALNAWQLVKELKEALS 257
LRYG NPHQ A + LN A + N DA A LV+E +
Sbjct: 287 LRYGENPHQDAAVYRDNTHAAASVVHADQLNPDAKALSYNNYNDADAALALVREFDDG-- 344
Query: 258 LPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVAL 317
PAAA KH +PAG A L D S+FG VAL
Sbjct: 345 -PAAAVIKHTNPAGCATADTLAD-----------------AYSDALSTDAKSAFGGIVAL 386
Query: 318 SDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKIDP-TYEPSLMEQKT 376
+ CD TAT ++ + V+APGY+ +A+ +L+ K N VL + P+ + +
Sbjct: 387 NRECDAETATRVADSFKEVVVAPGYTDDAVDVLTAK--SNLRVLDVGTLDGTPAPVTETP 444
Query: 377 IFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAVRDLIVATIALKYTQSNSVCFARDGQ 436
+ G L Q+RN TA+ + V TK++ + V ++ A L + +SN + FA +
Sbjct: 445 LVGGRLVQERNTWAPTADDLE--VVTKREPTAAEVETMLFAWRVLTHVKSNGILFAAGTE 502
Query: 437 VIGIGAGQQSRIHCTRLAGGKA 458
+G+G GQ SR+ +A KA
Sbjct: 503 TVGLGVGQVSRVDAVEIAAKKA 524
Score = 70.9 bits (166), Expect = 9e-11
Identities = 33/71 (46%), Positives = 43/71 (60%)
Query: 519 SQREEWIKKMDKVALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIA 578
++R+ K D +ASDAFFPF D I A + G+E + P GS ND +VIEA NEH +A
Sbjct: 524 AERDANGKTADGAVMASDAFFPFPDGIAAAAEAGIEAVIQPGGSKNDDQVIEAANEHGMA 583
Query: 579 LAHTNLRLFHH 589
+ T R F H
Sbjct: 584 MVFTGHRAFRH 594
>UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr15 scaffold_19, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 227
Score = 76.6 bits (180), Expect = 2e-12
Identities = 43/112 (38%), Positives = 60/112 (53%), Gaps = 3/112 (2%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+S+S+K L L SL G ++++ GGT AL NA ++ V +T P++L G VK
Sbjct: 24 ALISLSEKNDLAFLGNSLQILGYRIVSFGGTTLALENAWVSTTKVEQLTCFPKILDGHVK 83
Query: 66 TLHPAVHAGILARLSDS-DQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTV 116
TLHP + GIL R E + VVV NLYPF +P +T+
Sbjct: 84 TLHPNIQGGILPRRDQKHHMEALNEHGIGTFDVVVVNLYPFYD--KQPKLTI 133
>UniRef50_A0B9A9 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Methanosaeta thermophila PT|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Methanosaeta thermophila (strain DSM
6194 / PT) (Methanothrixthermophila (strain DSM 6194 /
PT))
Length = 451
Score = 72.9 bits (171), Expect = 2e-11
Identities = 93/319 (29%), Positives = 136/319 (42%), Gaps = 46/319 (14%)
Query: 189 SDYFRKQYSPGQAQLT--LRYGMNPHQKPAQVFTTRDSLPI---TTLNGAP-GFINLCDA 242
SD + +YS + LRYG N HQ+ A ++ L + LNG + N DA
Sbjct: 122 SDMYWPKYSVSLFEKVQDLRYGENWHQRAA-LYARPGGLGLFRAVKLNGKEMSYNNFVDA 180
Query: 243 LNAWQLVKELKE----ALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXXX 298
+++ +L E + P A KH +P G A G L EEA A +
Sbjct: 181 ETVLEMLIDLSEYDGVPTNRPLAVIVKHANPCGVAYGSDL--EEAYRWAFATDPK----- 233
Query: 299 XXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNY 358
S+FG + + D++TA I + +IAPGY P+AL+LL++ K N
Sbjct: 234 ----------SAFGGVIGFNMKVDLATAEAIGDSFVEVLIAPGYEPDALELLTRNK-PNR 282
Query: 359 CVLKI-------DPTYEPSLMEQKTIFGLTLEQKRNDAKITAELFKNVVTTKKDLPSNAV 411
+L I D Y +++FG + Q + I L VVT + P
Sbjct: 283 RILDIGDMLQRKDELYRGHAF--RSVFGGMMLQDYDREDI---LEWRVVTQRSPTPEEN- 336
Query: 412 RDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGKAALWWLRRHPSVLA 471
R L A KY +SN++ + + IGIG+GQ SR+ R KA L +V A
Sbjct: 337 RALRFAWKVTKYVKSNALVYTTADRTIGIGSGQVSRVDSARFGAEKAEEHGLDTRGTVAA 396
Query: 472 ----MRFRQGVTRAVQANA 486
FR G+ R +A A
Sbjct: 397 TDSFFPFRDGLDRVHEAGA 415
Score = 63.3 bits (147), Expect = 2e-08
Identities = 40/119 (33%), Positives = 59/119 (49%), Gaps = 5/119 (4%)
Query: 471 AMRFRQGVTRAVQANAIDNYVNGTVGSDLPLEQWDTLFEGKPPALFTDSQREEWIKKMDK 530
A+RF VT+ V++NA+ V T + + A F + EE
Sbjct: 338 ALRFAWKVTKYVKSNAL---VYTTADRTIGIGSGQV--SRVDSARFGAEKAEEHGLDTRG 392
Query: 531 VALASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
A+D+FFPFRD +DR + G + P GS D+EVI+A +EH +A+ T +R F H
Sbjct: 393 TVAATDSFFPFRDGLDRVHEAGATAVVHPGGSIRDREVIQAADEHGMAMVFTGMRHFRH 451
>UniRef50_Q46480 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=3; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Chromatium vinosum (Allochromatium
vinosum)
Length = 78
Score = 68.1 bits (159), Expect = 6e-10
Identities = 30/57 (52%), Positives = 38/57 (66%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASDAFFPFRD ID+A G++ + P GS D EVI A NEH +A+ T +R F H
Sbjct: 22 MASDAFFPFRDGIDQAAAAGIKAVIQPGGSMRDAEVIAAANEHGMAMVFTGMRHFRH 78
>UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 202
Score = 65.3 bits (152), Expect = 4e-09
Identities = 32/73 (43%), Positives = 45/73 (61%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVK 65
AL+S+S+K L L SL G ++++ GGT AL NA ++ V +T P++L G VK
Sbjct: 24 ALISLSEKNDLAFLGNSLQILGYRIVSFGGTTLALENAWVSTTKVEQLTCFPKILDGHVK 83
Query: 66 TLHPAVHAGILAR 78
TLHP + GIL R
Sbjct: 84 TLHPNIQGGILPR 96
>UniRef50_Q6AMF5 Cluster: Related to bifunctional purine
biosynthesis protein; n=8; Deltaproteobacteria|Rep:
Related to bifunctional purine biosynthesis protein -
Desulfotalea psychrophila
Length = 429
Score = 63.3 bits (147), Expect = 2e-08
Identities = 64/241 (26%), Positives = 104/241 (43%), Gaps = 38/241 (15%)
Query: 234 PGFINLCDALNAWQLVKELKEALSLPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELS 293
PG INL D N ++K L + PAA KH +P GAA D A+
Sbjct: 100 PGKINLTDIDNGLNIIKYL---MKKPAAVILKHNNPCGAA-----WDTSLAIAF------ 145
Query: 294 XXXXXXXXXXXXXXMSSFGDFVALSDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKK 353
+++FG V ++ PCD+ TA +++ + V AP + L++L+++
Sbjct: 146 ------NRALRCDRIAAFGGAVIMNRPCDLETAALLAENYLEVVCAPDFEEGTLEILARR 199
Query: 354 KGGNYCVLKID-----PTYEP-SLMEQKTIF--GLTLEQKR-NDAKITAELFKNVVTTK- 403
K N ++KI YE ++ K++ G+ ++Q N + +L T K
Sbjct: 200 K--NLRIIKIAGIDRLADYEKFRFIDFKSLIDGGIIVQQSPVNSIRSGDDLLPATTTRKG 257
Query: 404 ------KDLPSNAVRDLIVATIALKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAGGK 457
+ V D+I SNSV + +DG +GIG G+Q R+ +A K
Sbjct: 258 EDFACERQPTEQEVEDMIFGWAVEHGVTSNSVLYVKDGCTVGIGTGEQDRVGVAEIAVHK 317
Query: 458 A 458
A
Sbjct: 318 A 318
Score = 53.6 bits (123), Expect = 1e-05
Identities = 26/59 (44%), Positives = 35/59 (59%), Gaps = 2/59 (3%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACN--EHKIALAHTNLRLFHH 589
+ SDAFFPFRD D ++ G+ I GS D E I+ACN E ++A+ +T R F H
Sbjct: 371 MISDAFFPFRDGADIGIEQGITAILQAGGSMRDDETIKACNEAEPQVAMMYTGQRSFKH 429
>UniRef50_O28464 Cluster: Inosine monophosphate cyclohydrolase; n=1;
Archaeoglobus fulgidus|Rep: Inosine monophosphate
cyclohydrolase - Archaeoglobus fulgidus
Length = 157
Score = 59.3 bits (137), Expect = 3e-07
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 37/189 (19%)
Query: 7 LLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKT 66
L+S S K G+ LAK L+E G +++A+ GTA L+ G+ +S+IT E +KT
Sbjct: 4 LISSSVKEGIECLAKRLAEMGYEILATEGTADYLQEKGVNALKLSEITGIAE--SKSIKT 61
Query: 67 LHPAVHAGILARLSDSDQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVADAVENIDIG 126
LHP ++ I + E+ +VVV P+ ++ ENIDIG
Sbjct: 62 LHPKIYEMIFSG--------------EIKAVVV---IPY-------NLRENPCRENIDIG 97
Query: 127 GVTLLRAAAKNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDL 186
G++LLRAAAK PA YD +K + K + G ++ A + F TS+YD
Sbjct: 98 GISLLRAAAK-------AGVPAAYD--LKSFQ--KLVEVLEGKKRYNAAEVFRFTSEYDR 146
Query: 187 AISDYFRKQ 195
I+++ +
Sbjct: 147 TIAEWLENE 155
>UniRef50_A6PRZ4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Victivallis vadensis ATCC
BAA-548|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Victivallis vadensis ATCC BAA-548
Length = 372
Score = 57.6 bits (133), Expect = 9e-07
Identities = 27/57 (47%), Positives = 35/57 (61%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
+ASD FFPF D ++ A GV I +PSGS D +VI+ NE +AL H R+F H
Sbjct: 315 MASDGFFPFEDGVETAAAAGVTAIIAPSGSLRDADVIKRANELGVALFHAPERIFSH 371
Score = 54.0 bits (124), Expect = 1e-05
Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 54/277 (19%)
Query: 205 LRYGMNPHQ-----KPAQVFTTRDSLPITTLNGAPGF--INLCDALNAWQLVKELKEALS 257
LRYG NPHQ KPA + I NG G NL D A +VK
Sbjct: 35 LRYGTNPHQAASYYKPADEACVIGDMKILK-NGKSGLSQTNLEDISYALNIVK----FFD 89
Query: 258 LPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVAL 317
PA A KHV+P+GAA G P GE ++FG +A
Sbjct: 90 TPACAVMKHVNPSGAAAGRP------------GE--SLKTVYLKARDADARAAFGSSIAF 135
Query: 318 SDPCDVSTATIISREVSDGVIAPGYSPEALKLLSKKKGGNYCVLKIDPTYEPSLMEQKTI 377
+ D TA I + V+AP Y+P L++ + G Y + K + + +
Sbjct: 136 NKEVDQETAREIMSTFVECVVAPSYAPGVLEIFN--DGETYKLNKHIRIIQCGDLSKLPR 193
Query: 378 FGLTLEQKRNDAKITAE----LFKNVVTTKKD----LPSNAVR-------DLIVATIALK 422
F + + N K+ A+ + + ++T+ K +P+ A + AT A K
Sbjct: 194 FTGEAKDEHNTVKVLADGSLVIAQPLMTSMKSVADLVPAEAENKRCGRQVSTVAATDAQK 253
Query: 423 Y-----------TQSNSVCFARDGQVIGIGAGQQSRI 448
+ +SN V +DGQ + +G G+Q R+
Sbjct: 254 FDLLFAWYVNLSVRSNGVVIVKDGQTLSVGTGEQDRV 290
>UniRef50_A6DLC7 Cluster: IMP cyclohydrolase; n=1; Lentisphaera
araneosa HTCC2155|Rep: IMP cyclohydrolase - Lentisphaera
araneosa HTCC2155
Length = 369
Score = 54.4 bits (125), Expect = 8e-06
Identities = 24/57 (42%), Positives = 35/57 (61%)
Query: 533 LASDAFFPFRDNIDRAVQCGVEYIGSPSGSNNDQEVIEACNEHKIALAHTNLRLFHH 589
++SD FFPF D ++ A GV + +P+GS D +VI+ NE +AL H R+F H
Sbjct: 312 MSSDGFFPFSDGVETAATAGVTAVIAPAGSLKDADVIKRANELGVALFHAPERIFSH 368
Score = 40.3 bits (90), Expect = 0.14
Identities = 45/154 (29%), Positives = 62/154 (40%), Gaps = 29/154 (18%)
Query: 205 LRYGMNPHQ-----KPAQVFTTRDSLPITTLNGAPGF--INLCDALNAWQLVKELKEALS 257
LRYG NPHQ KPA + + L + NG G NL D A +VK E
Sbjct: 36 LRYGTNPHQTAAFYKPAGLESPIGDLKVLK-NGKSGLSQTNLEDISYALNIVKFFDE--- 91
Query: 258 LPAAASFKHVSPAGAAVGLPLTDEEAAVCMVAGELSXXXXXXXXXXXXXXMSSFGDFVAL 317
P A KHV+P+GAA + D ++FG +A
Sbjct: 92 -PTCAVMKHVNPSGAATAANVYD-----------------AYIQARDADPRAAFGSTIAF 133
Query: 318 SDPCDVSTATIISREVSDGVIAPGYSPEALKLLS 351
+ D +TA I + V+AP S EA+ + +
Sbjct: 134 NSTVDEATAREIMSSFVECVVAPTVSEEAMAVFT 167
>UniRef50_Q5KN32 Cluster: IMP cyclohydrolase, putative; n=1;
Filobasidiella neoformans|Rep: IMP cyclohydrolase,
putative - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 120
Score = 54.0 bits (124), Expect = 1e-05
Identities = 26/39 (66%), Positives = 33/39 (84%), Gaps = 1/39 (2%)
Query: 409 NAVRDLIVATIAL-KYTQSNSVCFARDGQVIGIGAGQQS 446
++V DL+VAT+AL KYT+SNSVC A +G VIG+G GQQS
Sbjct: 14 SSVTDLVVATLALNKYTRSNSVCHALNGTVIGLGTGQQS 52
>UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 153
Score = 52.0 bits (119), Expect = 4e-05
Identities = 28/64 (43%), Positives = 32/64 (50%), Gaps = 1/64 (1%)
Query: 59 MLGGRVKTLHPAVHAGILARLSDS-DQEDMKRQKYEMISVVVCNLYPFVQTVSKPDVTVA 117
ML G VKTLHP +H GILAR E + VVV NLYPF VS +
Sbjct: 1 MLDGHVKTLHPNIHGGILARRDQKHHMEALNEHGIGTFDVVVVNLYPFYDKVSLGGIEFE 60
Query: 118 DAVE 121
D +E
Sbjct: 61 DEIE 64
>UniRef50_Q5FJY6 Cluster: Carbamoyl-phosphate synthase large subunit;
n=5; Lactobacillus|Rep: Carbamoyl-phosphate synthase
large subunit - Lactobacillus acidophilus
Length = 1061
Score = 42.3 bits (95), Expect = 0.035
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 3/88 (3%)
Query: 4 GTALLSV--SDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLG 61
GT +SV DK + LA+ G +L+A+ GTA AG+T V + P L
Sbjct: 939 GTIFISVRDEDKEKVTQLARRFDRLGFKLVATEGTANIFAEAGITTGIVEKVHNNPRNLL 998
Query: 62 GRVKTLHPAVHAGILARLSDSDQEDMKR 89
+++ H V + LSD+ ED R
Sbjct: 999 EKIRQ-HKIVMVVNITNLSDAASEDALR 1025
>UniRef50_Q4RQF9 Cluster: Chromosome 17 SCAF15006, whole genome
shotgun sequence; n=3; Clupeocephala|Rep: Chromosome 17
SCAF15006, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 190
Score = 40.3 bits (90), Expect = 0.14
Identities = 31/70 (44%), Positives = 39/70 (55%), Gaps = 5/70 (7%)
Query: 1 MCSGTALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEML 60
+ S AL+ VS K GL S++ +S L L A+G A +N GLT +VS T APEML
Sbjct: 29 LSSAEALVDVSYK-GLNSMSTIISPASLLLSATG--ILAFKNCGLT-DEVSTFT-APEML 83
Query: 61 GGRVKTLHPA 70
GR PA
Sbjct: 84 QGRASASRPA 93
>UniRef50_Q73FN1 Cluster: Carbamoyl-phosphate synthase, large subunit;
n=5; Bacteria|Rep: Carbamoyl-phosphate synthase, large
subunit - Wolbachia pipientis wMel
Length = 1151
Score = 39.1 bits (87), Expect = 0.32
Identities = 21/52 (40%), Positives = 32/52 (61%), Gaps = 2/52 (3%)
Query: 4 GTALLSVSD--KTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDI 53
GTAL+SV D K +L +A+ L E ++ A+ GTA+ L N G+ Q V+ +
Sbjct: 1021 GTALVSVKDDDKKYILPVARMLKELSFEIYATKGTASYLNNNGIAAQAVNKV 1072
>UniRef50_P77886 Cluster: Carbamoyl-phosphate synthase
pyrimidine-specific large chain; n=32; Firmicutes|Rep:
Carbamoyl-phosphate synthase pyrimidine-specific large
chain - Lactobacillus plantarum
Length = 1058
Score = 39.1 bits (87), Expect = 0.32
Identities = 30/85 (35%), Positives = 42/85 (49%), Gaps = 5/85 (5%)
Query: 4 GTALLSV--SDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLG 61
G LL+V DK ++LAK G QL+A+ GTATAL GL V V I L
Sbjct: 936 GNVLLTVRDEDKPETVALAKRFHALGYQLLATRGTATALTTHGLPVTTVDKIDSGERDLL 995
Query: 62 GRVKTLHPAVHAGILARLSDSDQED 86
R++ V ++ +SD +Q +
Sbjct: 996 HRMEAGEIQV---VINTVSDEEQAE 1017
>UniRef50_A6CPS0 Cluster: Carbamoyl-phosphate synthase large
subunit; n=1; Bacillus sp. SG-1|Rep:
Carbamoyl-phosphate synthase large subunit - Bacillus
sp. SG-1
Length = 167
Score = 38.7 bits (86), Expect = 0.43
Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 3/60 (5%)
Query: 4 GTALLSVSDKTG--LLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDI-TRAPEML 60
G+ LL+V+DK + LAK G Q++A+ GTA LR A + V++V I + P +L
Sbjct: 33 GSVLLTVADKDKDEAIGLAKRFVNIGYQILATKGTADVLRTADIPVKEVDKIGSEGPTLL 92
>UniRef50_O50236 Cluster: Carbamoyl-phosphate synthase large chain;
n=38; cellular organisms|Rep: Carbamoyl-phosphate
synthase large chain - Zymomonas mobilis
Length = 1112
Score = 38.3 bits (85), Expect = 0.57
Identities = 19/53 (35%), Positives = 36/53 (67%), Gaps = 2/53 (3%)
Query: 3 SGTALLSV--SDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDI 53
+GT +SV SDK ++ K+L++ G++L+A+ GTA L++ G+ V+ V+ +
Sbjct: 978 AGTFFISVKDSDKAQIVEPIKALTDLGIKLVATDGTARYLQSKGVPVERVNKV 1030
>UniRef50_UPI0000DB7FED Cluster: PREDICTED: similar to
Carbamoyl-phosphate synthase [ammonia], mitochondrial
precursor (Carbamoyl-phosphate synthetase I) (CPSase I);
n=1; Apis mellifera|Rep: PREDICTED: similar to
Carbamoyl-phosphate synthase [ammonia], mitochondrial
precursor (Carbamoyl-phosphate synthetase I) (CPSase I)
- Apis mellifera
Length = 202
Score = 37.9 bits (84), Expect = 0.75
Identities = 24/50 (48%), Positives = 30/50 (60%), Gaps = 2/50 (4%)
Query: 3 SGTALLSV--SDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDV 50
SG ALLS+ DK LL +AK L G + A+ GTA AL+ AG+ Q V
Sbjct: 74 SGKALLSIREQDKPRLLEVAKRLITHGFSIDATLGTAKALQQAGIACQIV 123
>UniRef50_Q8XZ83 Cluster: Carbamoyl-phosphate synthase large chain;
n=155; cellular organisms|Rep: Carbamoyl-phosphate
synthase large chain - Ralstonia solanacearum
(Pseudomonas solanacearum)
Length = 1081
Score = 37.5 bits (83), Expect = 0.99
Identities = 19/52 (36%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 4 GTALLSV--SDKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDI 53
GT L++V SDK + +A++L G ++A+ GTA+A+ AG+ V+ V+ +
Sbjct: 951 GTVLMTVKDSDKPRAIEVARTLHTLGYPIVATRGTASAIEAAGIPVRVVNKV 1002
>UniRef50_A6NS15 Cluster: Putative uncharacterized protein; n=1;
Bacteroides capillosus ATCC 29799|Rep: Putative
uncharacterized protein - Bacteroides capillosus ATCC
29799
Length = 1098
Score = 36.7 bits (81), Expect = 1.7
Identities = 16/50 (32%), Positives = 34/50 (68%), Gaps = 1/50 (2%)
Query: 12 DKTGLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRA-PEML 60
DK ++ +A+ +++ G++++A+ GTA AL AG+ + V+ ++ A P +L
Sbjct: 980 DKGEIVGIARGMADMGIEILATSGTADALEAAGVQCRRVARVSEAHPNIL 1029
>UniRef50_A6DMV9 Cluster: Putative uncharacterized protein; n=1;
Lentisphaera araneosa HTCC2155|Rep: Putative
uncharacterized protein - Lentisphaera araneosa HTCC2155
Length = 708
Score = 36.3 bits (80), Expect = 2.3
Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 7/93 (7%)
Query: 153 VVKEIKENKHHQTTLGTRQRLALKAFTHTSDYDLAI----SDYFRKQYSPGQAQLTLRYG 208
+V + ENKHH+ T+ ++ +A T AI S F +SPG L +
Sbjct: 591 MVPRLSENKHHENTV--KKAMAGVKLTKLKQLSAAIPKSYSSDFNLSFSPGSKSLAIA-R 647
Query: 209 MNPHQKPAQVFTTRDSLPITTLNGAPGFINLCD 241
KP + R+ PIT G ++L D
Sbjct: 648 FRQDGKPIYLLVNREQKPITASVAGKGRVSLLD 680
>UniRef50_UPI0000382898 Cluster: COG0138: AICAR transformylase/IMP
cyclohydrolase PurH (only IMP cyclohydrolase domain in
Aful); n=1; Magnetospirillum magnetotacticum MS-1|Rep:
COG0138: AICAR transformylase/IMP cyclohydrolase PurH
(only IMP cyclohydrolase domain in Aful) -
Magnetospirillum magnetotacticum MS-1
Length = 50
Score = 35.5 bits (78), Expect = 4.0
Identities = 18/40 (45%), Positives = 24/40 (60%)
Query: 6 ALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRNAGL 45
ALLSVSDKTGL A +L G++L+++ AGL
Sbjct: 4 ALLSVSDKTGLTDFAAALIGQGVELVSTAAPIARXHRAGL 43
>UniRef50_A4BV92 Cluster: Glutamate dehydrogenase; n=3; cellular
organisms|Rep: Glutamate dehydrogenase - Nitrococcus
mobilis Nb-231
Length = 549
Score = 35.5 bits (78), Expect = 4.0
Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 2/63 (3%)
Query: 1 MCSGTALLSVSDKTGLLSLAKSLSECGLQLIASGGTATALRN-AGLTVQDVSDITRAPEM 59
+ TA++ G+ + A L+ECG++++A +TA+ N AGL + ++ D R ++
Sbjct: 342 LAKSTAVVQGFGNVGMHAAA-FLAECGVKVVAVSDVSTAIYNPAGLPIAELRDYVREHQL 400
Query: 60 LGG 62
L G
Sbjct: 401 LAG 403
>UniRef50_Q82GJ7 Cluster: Putative uncharacterized protein; n=1;
Streptomyces avermitilis|Rep: Putative uncharacterized
protein - Streptomyces avermitilis
Length = 303
Score = 35.1 bits (77), Expect = 5.3
Identities = 24/85 (28%), Positives = 37/85 (43%), Gaps = 5/85 (5%)
Query: 112 PDVTVADAVENIDIGGVTLLRAAA--KNHDRVTVVCDPADYDAVVKEIKENKHHQTTLGT 169
P AD+V DI L AA K+ R AD D ++K NK +GT
Sbjct: 31 PAAQAADSVSRADIAHAWGLSTAASGKSGFRPATAGTAADLDVTFSDMKVNKSKNIVVGT 90
Query: 170 RQRLALK---AFTHTSDYDLAISDY 191
+ +A+ TH +D D++ ++
Sbjct: 91 TKEVAIPVTYTLTHAADLDMSEDNF 115
>UniRef50_Q0F2Y5 Cluster: ATP phosphoribosyltransferase regulatory
subunit; n=1; Mariprofundus ferrooxydans PV-1|Rep: ATP
phosphoribosyltransferase regulatory subunit -
Mariprofundus ferrooxydans PV-1
Length = 318
Score = 34.3 bits (75), Expect = 9.2
Identities = 32/115 (27%), Positives = 49/115 (42%), Gaps = 6/115 (5%)
Query: 421 LKYTQSNSVCFARDGQVIGIGAGQQSRIHCTRLAG--GKAALWWLRRHPSVLAMRFRQGV 478
LK + S ++ AR G Q+ I C +AG G A + L S+LA F V
Sbjct: 98 LKLSYSGTIMMARPELRGGSRQQWQTGIECLGIAGAHGDAEVMHLAAR-SMLAAGFTNPV 156
Query: 479 TRAVQANAIDNYVNGTVGSDLPLEQWDTLFEGKPPALFTDSQREEWIKKMDKVAL 533
+ + V GS +PL++W L + P + REE + + + AL
Sbjct: 157 LQVGHIGLLKALV---AGSSMPLDKWTALVNRRSPDDLKHAMREETLSEPVRKAL 208
>UniRef50_P53127 Cluster: SANT domain-containing protein 2; n=2;
Saccharomyces cerevisiae|Rep: SANT domain-containing
protein 2 - Saccharomyces cerevisiae (Baker's yeast)
Length = 1403
Score = 34.3 bits (75), Expect = 9.2
Identities = 19/71 (26%), Positives = 30/71 (42%), Gaps = 9/71 (12%)
Query: 180 HTSDYDLAISDYFRKQYSPGQAQLTLRYGMN---------PHQKPAQVFTTRDSLPITTL 230
HT Y +A+ Y + ++ P Q L + P QKP + T+D P+ +
Sbjct: 808 HTQLYKMAVRSYRKNEFHPETMQRDLELFIEDNKEVRKAIPEQKPERAKNTKDEFPVNII 867
Query: 231 NGAPGFINLCD 241
+PG I D
Sbjct: 868 RQSPGTIKTSD 878
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.132 0.386
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 621,637,913
Number of Sequences: 1657284
Number of extensions: 24929325
Number of successful extensions: 62465
Number of sequences better than 10.0: 78
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 62074
Number of HSP's gapped (non-prelim): 196
length of query: 589
length of database: 575,637,011
effective HSP length: 105
effective length of query: 484
effective length of database: 401,622,191
effective search space: 194385140444
effective search space used: 194385140444
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 75 (34.3 bits)
- SilkBase 1999-2023 -