Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002444-TA|BGIBMGA002444-PA|IPR001958|Tetracycline
resistance protein, IPR011701|Major facilitator superfamily MFS_1,
IPR007114|Major facilitator superfamily
(398 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000D573B2 Cluster: PREDICTED: similar to tumor supp... 240 4e-62
UniRef50_A7RPG8 Cluster: Predicted protein; n=1; Nematostella ve... 180 6e-44
UniRef50_UPI00005842F8 Cluster: PREDICTED: hypothetical protein ... 147 4e-34
UniRef50_Q8NBP5 Cluster: Major facilitator superfamily domain-co... 133 7e-30
UniRef50_UPI0000D5728F Cluster: PREDICTED: hypothetical protein;... 131 3e-29
UniRef50_A7HKI1 Cluster: Major facilitator superfamily MFS_1; n=... 99 2e-19
UniRef50_Q4S0N3 Cluster: Chromosome 2 SCAF14781, whole genome sh... 95 4e-18
UniRef50_UPI000038DC0A Cluster: COG0477: Permeases of the major ... 90 1e-16
UniRef50_Q9KDN7 Cluster: Multidrug-efflux transporter; n=1; Baci... 89 1e-16
UniRef50_A7NRD2 Cluster: Major facilitator superfamily MFS_1; n=... 88 4e-16
UniRef50_Q8DMH7 Cluster: Multidrug-efflux transporter; n=2; Cyan... 82 2e-14
UniRef50_A0GXY1 Cluster: Major facilitator superfamily MFS_1; n=... 82 3e-14
UniRef50_Q8KDQ3 Cluster: Drug resistance protein, putative; n=10... 80 1e-13
UniRef50_Q9RX43 Cluster: Tetracycline-efflux transporter; n=2; D... 78 4e-13
UniRef50_A7SCJ0 Cluster: Predicted protein; n=2; Nematostella ve... 78 5e-13
UniRef50_Q6MQK5 Cluster: Multidrug resistance protein; n=1; Bdel... 77 1e-12
UniRef50_Q8GR72 Cluster: Multidrug efflux pump; n=7; Lactobacill... 76 1e-12
UniRef50_Q56RY7 Cluster: TetA; n=4; Acinetobacter|Rep: TetA - Ac... 75 2e-12
UniRef50_A6G4P6 Cluster: Multidrug resistance protein, putative;... 74 6e-12
UniRef50_Q0LMR4 Cluster: Major facilitator superfamily MFS_1 pre... 74 8e-12
UniRef50_A7H6K9 Cluster: Major facilitator superfamily MFS_1; n=... 73 2e-11
UniRef50_Q6KYT7 Cluster: Tetracycline resistance protein; n=1; P... 71 7e-11
UniRef50_P0A0J7 Cluster: Quinolone resistance protein norA; n=23... 71 7e-11
UniRef50_UPI000065CAB2 Cluster: Organic cation transporter-like ... 70 1e-10
UniRef50_Q0C4X1 Cluster: Tetracycline-efflux transporter; n=1; H... 70 1e-10
UniRef50_Q5N0B7 Cluster: Multidrug-efflux transporter quinolene ... 69 3e-10
UniRef50_A3VAE1 Cluster: Tetracycline resistance protein; n=3; R... 69 3e-10
UniRef50_P02981 Cluster: Tetracycline resistance protein, class ... 69 3e-10
UniRef50_Q28RT4 Cluster: Major facilitator superfamily MFS_1; n=... 68 4e-10
UniRef50_Q32LS0 Cluster: Zgc:123168; n=9; Euteleostomi|Rep: Zgc:... 68 5e-10
UniRef50_Q3BM88 Cluster: Drug:H+ antiporter-1 family protein; n=... 67 7e-10
UniRef50_A3U1K1 Cluster: Putative transport transmembrane protei... 67 7e-10
UniRef50_A5GP24 Cluster: Permease of the major facilitator super... 66 1e-09
UniRef50_Q0W0M4 Cluster: Putative permease; n=1; uncultured meth... 66 2e-09
UniRef50_Q2MDB3 Cluster: Tetracycline efllux protein; n=6; Prote... 65 4e-09
UniRef50_A3I4T4 Cluster: Blt; n=1; Bacillus sp. B14905|Rep: Blt ... 64 5e-09
UniRef50_Q4J724 Cluster: Drug transporter; n=1; Sulfolobus acido... 64 6e-09
UniRef50_Q65F99 Cluster: Blt; n=2; Bacillus|Rep: Blt - Bacillus ... 64 8e-09
UniRef50_Q04U94 Cluster: Permease; n=5; Bacteria|Rep: Permease -... 64 8e-09
UniRef50_A0LD21 Cluster: Major facilitator superfamily MFS_1; n=... 64 8e-09
UniRef50_UPI0000E47E1B Cluster: PREDICTED: hypothetical protein;... 63 1e-08
UniRef50_Q7UXZ3 Cluster: Tetracycline-efflux transporter; n=1; P... 63 1e-08
UniRef50_A5G2L8 Cluster: Major facilitator superfamily MFS_1; n=... 63 1e-08
UniRef50_Q07282 Cluster: Tetracycline resistance protein, class ... 63 1e-08
UniRef50_A3UGP9 Cluster: Probable transporter; n=1; Oceanicaulis... 62 2e-08
UniRef50_Q8VVJ1 Cluster: TetA protein; n=5; Actinomycetales|Rep:... 62 2e-08
UniRef50_A6U8Y2 Cluster: Major facilitator superfamily MFS_1; n=... 62 2e-08
UniRef50_Q0W242 Cluster: Putative permease; n=1; uncultured meth... 62 3e-08
UniRef50_A0Z2L4 Cluster: Multidrug-efflux transporter; n=1; mari... 61 4e-08
UniRef50_A7D0E0 Cluster: Major facilitator superfamily MFS_1; n=... 61 4e-08
UniRef50_Q846S5 Cluster: Adventurous gliding motility protein P;... 61 6e-08
UniRef50_Q8F6D6 Cluster: Tetracycline resistance protein, class ... 60 1e-07
UniRef50_Q89NI8 Cluster: Bll3850 protein; n=1; Bradyrhizobium ja... 60 1e-07
UniRef50_Q9RN46 Cluster: 12-TMS multidrug efflux protein homolog... 59 2e-07
UniRef50_Q6MQ30 Cluster: Tetracycline-efflux transporter; n=1; B... 59 2e-07
UniRef50_Q0W1K3 Cluster: Putative permease; n=1; uncultured meth... 59 2e-07
UniRef50_Q89MY8 Cluster: Tetracycline resistance protein; n=7; B... 59 2e-07
UniRef50_Q2G331 Cluster: Major facilitator superfamily MFS_1; n=... 59 2e-07
UniRef50_Q21E97 Cluster: Major facilitator superfamily MFS_1; n=... 58 5e-07
UniRef50_Q1D6T2 Cluster: Putative multidrug resistance protein; ... 58 5e-07
UniRef50_A4ING5 Cluster: Multidrug-efflux transporter; n=1; Geob... 58 5e-07
UniRef50_Q4ZVR8 Cluster: General substrate transporter:Major fac... 57 7e-07
UniRef50_Q9KBZ9 Cluster: Multidrug-efflux transporter; n=2; Baci... 57 9e-07
UniRef50_Q5WGK5 Cluster: Major facilitator (MFS) superfamily mul... 57 9e-07
UniRef50_Q9Z479 Cluster: Drug efflux protein TetA; n=3; Proteoba... 57 9e-07
UniRef50_Q1GPE1 Cluster: Major facilitator superfamily MFS_1; n=... 57 9e-07
UniRef50_A1B6I1 Cluster: Major facilitator superfamily MFS_1; n=... 56 1e-06
UniRef50_Q97L04 Cluster: Permease, probably tetracycline resista... 56 2e-06
UniRef50_A5FYH1 Cluster: Major facilitator superfamily MFS_1 pre... 56 2e-06
UniRef50_A3MSL0 Cluster: Major facilitator superfamily MFS_1; n=... 56 2e-06
UniRef50_Q8F4V6 Cluster: Tetracycline resistance protein; n=4; L... 56 2e-06
UniRef50_UPI0001555554 Cluster: PREDICTED: similar to Solute car... 54 5e-06
UniRef50_A3VN57 Cluster: Permease; n=1; Parvularcula bermudensis... 54 5e-06
UniRef50_A3CSW8 Cluster: Major facilitator superfamily MFS_1; n=... 54 5e-06
UniRef50_Q8ZUX8 Cluster: Tetracycline resistance protein; n=1; P... 54 7e-06
UniRef50_Q0AX92 Cluster: Multidrug-efflux transporter; n=1; Synt... 54 9e-06
UniRef50_Q6V4U1 Cluster: Putative multidrug efflux protein; n=1;... 53 1e-05
UniRef50_A5V1Q7 Cluster: Major facilitator superfamily MFS_1; n=... 53 2e-05
UniRef50_A3IH26 Cluster: Multidrug resistance protein, putative;... 53 2e-05
UniRef50_Q96BI1 Cluster: Organic cation transporter-like protein... 52 2e-05
UniRef50_Q9A8S0 Cluster: Tetracycline resistance protein; n=3; A... 52 3e-05
UniRef50_A6H1H8 Cluster: Major facilitator superfamily (MFS) per... 52 3e-05
UniRef50_A2SG94 Cluster: Tetracycline-efflux transporter; n=2; P... 52 3e-05
UniRef50_A3WCL4 Cluster: Permease; n=1; Erythrobacter sp. NAP1|R... 52 4e-05
UniRef50_Q9I4K4 Cluster: Probable major facilitator superfamily ... 51 5e-05
UniRef50_Q62C01 Cluster: Multidrug resistance protein; n=16; Pro... 51 5e-05
UniRef50_Q1IVW2 Cluster: Major facilitator superfamily MFS_1; n=... 51 5e-05
UniRef50_A4AC28 Cluster: Tetracycline-efflux transporter; n=1; C... 51 5e-05
UniRef50_Q8NM37 Cluster: Permeases of the major facilitator supe... 51 6e-05
UniRef50_P39843 Cluster: Multidrug resistance protein 2; n=18; F... 51 6e-05
UniRef50_Q75TC8 Cluster: Multidrug-efflux transporter; n=3; Geob... 50 8e-05
UniRef50_A3H8C5 Cluster: Major facilitator superfamily MFS_1; n=... 50 1e-04
UniRef50_Q192M5 Cluster: Major facilitator superfamily MFS_1; n=... 49 2e-04
UniRef50_Q9UYY0 Cluster: Multidrug resistance protein; n=4; Ther... 49 2e-04
UniRef50_Q12ZN0 Cluster: Major facilitator superfamily (MFS) tra... 49 2e-04
UniRef50_A3I9G6 Cluster: Multidrug-efflux transporter; n=1; Baci... 49 2e-04
UniRef50_A3ZND9 Cluster: Multidrug resistance protein; n=1; Blas... 48 3e-04
UniRef50_A3HS41 Cluster: Major facilitator superfamily (MFS_1) t... 48 3e-04
UniRef50_UPI0000D9D6E6 Cluster: PREDICTED: similar to tumor supp... 47 8e-04
UniRef50_Q0W0C7 Cluster: Putative permease; n=1; uncultured meth... 47 8e-04
UniRef50_UPI00015B5592 Cluster: PREDICTED: similar to GA19110-PA... 46 0.001
UniRef50_Q88YJ0 Cluster: Multidrug transport protein; n=5; Lacto... 46 0.001
UniRef50_A3I7Q7 Cluster: Multidrug-efflux transporter; n=2; Baci... 46 0.001
UniRef50_A3CSK5 Cluster: Major facilitator superfamily MFS_1 pre... 46 0.001
UniRef50_Q18R58 Cluster: Major facilitator superfamily MFS_1 pre... 46 0.002
UniRef50_A1I922 Cluster: Major facilitator superfamily MFS_1 pre... 46 0.002
UniRef50_Q14728 Cluster: Tetracycline transporter-like protein; ... 46 0.002
UniRef50_Q7NRP4 Cluster: Probable multidrug resistance protein; ... 45 0.004
UniRef50_Q9V395 Cluster: CG5760-PA; n=5; Endopterygota|Rep: CG57... 45 0.004
UniRef50_Q83CB9 Cluster: Multidrug transporter, putative; n=5; C... 44 0.005
UniRef50_Q1PJF6 Cluster: Multidrug efflux transporter, MFS famil... 44 0.005
UniRef50_Q19296 Cluster: Putative uncharacterized protein; n=2; ... 44 0.005
UniRef50_A0B6G9 Cluster: Major facilitator superfamily MFS_1; n=... 44 0.005
UniRef50_UPI0000DAE55E Cluster: hypothetical protein Rgryl_01000... 44 0.007
UniRef50_Q58955 Cluster: Uncharacterized MFS-type transporter MJ... 44 0.007
UniRef50_UPI0000E4A5F1 Cluster: PREDICTED: similar to MGC84630 p... 44 0.009
UniRef50_A4SYC7 Cluster: Major facilitator superfamily MFS_1; n=... 44 0.009
UniRef50_A4M6X8 Cluster: Major facilitator superfamily MFS_1; n=... 44 0.009
UniRef50_Q8RBR4 Cluster: Permeases of the major facilitator supe... 43 0.012
UniRef50_Q2W6Q6 Cluster: Permease of the major facilitator super... 43 0.012
UniRef50_Q2AIY8 Cluster: Major facilitator superfamily MFS_1 pre... 43 0.012
UniRef50_A6LMN9 Cluster: Major facilitator superfamily MFS_1; n=... 43 0.012
UniRef50_Q0W2N8 Cluster: Putative permease; n=1; uncultured meth... 43 0.012
UniRef50_Q2SGJ5 Cluster: Permease of the major facilitator super... 43 0.016
UniRef50_A7PP07 Cluster: Chromosome chr8 scaffold_23, whole geno... 43 0.016
UniRef50_Q54IT2 Cluster: Putative uncharacterized protein; n=1; ... 43 0.016
UniRef50_Q3Y153 Cluster: Major facilitator superfamily; n=2; Lac... 42 0.022
UniRef50_Q0RV66 Cluster: Multidrug resistance transporter, MFS s... 42 0.022
UniRef50_A6BZ30 Cluster: Major facilitator superfamily MFS_1 tra... 42 0.022
UniRef50_Q9Y918 Cluster: Putative MFS transporter; n=1; Aeropyru... 42 0.022
UniRef50_Q8TUA4 Cluster: Class H tetracycline resistance efflux ... 42 0.022
UniRef50_Q9KFK7 Cluster: BH0472 protein; n=1; Bacillus haloduran... 42 0.028
UniRef50_Q81YJ0 Cluster: Major facilitator family transporter; n... 42 0.028
UniRef50_P73784 Cluster: Quinolene resistance protein; NorA; n=1... 42 0.028
UniRef50_Q183L2 Cluster: Putative polysaccharide polymerase; n=2... 42 0.028
UniRef50_Q9A9E1 Cluster: Multidrug resistance protein, putative;... 42 0.038
UniRef50_Q9LA76 Cluster: Valanimycin resistance; n=1; Streptomyc... 42 0.038
UniRef50_A5K9J4 Cluster: Transporter, putative; n=6; Plasmodium|... 42 0.038
UniRef50_Q0V4C7 Cluster: Putative uncharacterized protein; n=1; ... 42 0.038
UniRef50_Q0W1D9 Cluster: Permease; n=1; uncultured methanogenic ... 42 0.038
UniRef50_Q2AID5 Cluster: General substrate transporter:Major fac... 41 0.050
UniRef50_A7A924 Cluster: Putative uncharacterized protein; n=1; ... 41 0.050
UniRef50_A0YM33 Cluster: General substrate transporter; n=4; Cya... 41 0.050
UniRef50_A3H5L9 Cluster: Major facilitator superfamily MFS_1 pre... 41 0.050
UniRef50_A7CRQ2 Cluster: Major facilitator superfamily MFS_1 pre... 41 0.066
UniRef50_A6LNR2 Cluster: Putative uncharacterized protein; n=1; ... 41 0.066
UniRef50_A3YI10 Cluster: Major facilitator family transporter; n... 41 0.066
UniRef50_Q2FS41 Cluster: Major facilitator superfamily MFS_1; n=... 41 0.066
UniRef50_Q7U3D8 Cluster: Multidrug efflux transporter, MFS famil... 40 0.087
UniRef50_Q03KW0 Cluster: Permease of the major facilitator super... 40 0.087
UniRef50_UPI0000498C9C Cluster: hypothetical protein 100.t00005;... 40 0.11
UniRef50_Q3IGF3 Cluster: Putative uncharacterized protein; n=1; ... 40 0.11
UniRef50_Q41CM9 Cluster: Major facilitator superfamily MFS_1 pre... 40 0.11
UniRef50_A6PC97 Cluster: Drug resistance transporter, Bcr/CflA s... 40 0.11
UniRef50_UPI00015978DB Cluster: putative permease MDR type; n=1;... 40 0.15
UniRef50_Q6AJB3 Cluster: Related to quinolone resistance protein... 40 0.15
UniRef50_Q67MU6 Cluster: Putative multidrug efflux protein; n=1;... 40 0.15
UniRef50_O34307 Cluster: YvmA; n=4; Bacillus|Rep: YvmA - Bacillu... 40 0.15
UniRef50_Q034A5 Cluster: Permease of the major facilitator super... 40 0.15
UniRef50_A0Z910 Cluster: Major facilitator superfamily MFS_1; n=... 40 0.15
UniRef50_A7RGX9 Cluster: Predicted protein; n=1; Nematostella ve... 40 0.15
UniRef50_A2F7Q4 Cluster: Putative uncharacterized protein; n=2; ... 40 0.15
UniRef50_Q81KN5 Cluster: Drug resistance transporter, EmrB/QacA ... 39 0.20
UniRef50_Q2JNV3 Cluster: Transporter, drug:H+ antiporter-1 (12 s... 39 0.20
UniRef50_A0EFI4 Cluster: Chromosome undetermined scaffold_93, wh... 39 0.20
UniRef50_Q757R9 Cluster: AEL057Cp; n=1; Eremothecium gossypii|Re... 39 0.20
UniRef50_A7E4U3 Cluster: Putative uncharacterized protein; n=1; ... 39 0.20
UniRef50_Q4JAS6 Cluster: Conserved membrane protein; n=6; Sulfol... 39 0.20
UniRef50_Q8ZQ25 Cluster: Multidrug resistance protein mdtG; n=36... 39 0.20
UniRef50_Q74FA3 Cluster: Major facilitator family transporter; n... 39 0.27
UniRef50_Q3WEI6 Cluster: Drug resistance transporter EmrB/QacA s... 39 0.27
UniRef50_A3TZ27 Cluster: Drug resistance transporter, EmrB/QacA ... 39 0.27
UniRef50_A4HMU9 Cluster: Putative uncharacterized protein; n=3; ... 39 0.27
UniRef50_Q59T81 Cluster: Potential transmembrane protein; n=2; S... 39 0.27
UniRef50_Q0W6E0 Cluster: Putative permease; n=1; uncultured meth... 39 0.27
UniRef50_Q5YZV3 Cluster: Putative transporter; n=1; Nocardia far... 38 0.35
UniRef50_Q39FZ4 Cluster: Major facilitator superfamily (MFS_1) t... 38 0.35
UniRef50_Q143W2 Cluster: Major facilitator superfamily (MFS) met... 38 0.35
UniRef50_A6SYA1 Cluster: Transporter of the MFS superfamily; n=3... 38 0.35
UniRef50_A5US69 Cluster: Major facilitator superfamily MFS_1 pre... 38 0.35
UniRef50_A3XKG1 Cluster: Multidrug-efflux transporter; n=2; Flav... 38 0.35
UniRef50_Q97WR9 Cluster: Multidrug resistance protein; n=6; Sulf... 38 0.35
UniRef50_Q649G3 Cluster: Multidrug efflux transporter; n=1; uncu... 38 0.35
UniRef50_Q664N1 Cluster: Protein tsgA homolog; n=45; Gammaproteo... 38 0.35
UniRef50_UPI0000E46651 Cluster: PREDICTED: hypothetical protein;... 38 0.46
UniRef50_Q74KS3 Cluster: Major facilitator superfamily permease;... 38 0.46
UniRef50_Q63RQ1 Cluster: MFS-family transport protein; n=28; Bur... 38 0.46
UniRef50_Q47P56 Cluster: Drug resistance transporter Bcr/CflA su... 38 0.46
UniRef50_Q2RZH2 Cluster: Permease, major facilitator superfamily... 38 0.46
UniRef50_Q0SEY0 Cluster: Anion cation symporter, MFS family prot... 38 0.46
UniRef50_A6LQ19 Cluster: Drug resistance transporter, EmrB/QacA ... 38 0.46
UniRef50_A5D4M5 Cluster: Arabinose efflux permease; n=1; Pelotom... 38 0.46
UniRef50_A4J280 Cluster: Major facilitator superfamily MFS_1; n=... 38 0.46
UniRef50_A4BAS3 Cluster: Putative uncharacterized protein; n=1; ... 38 0.46
UniRef50_A3JJB0 Cluster: Transport protein; n=2; Marinobacter|Re... 38 0.46
UniRef50_A2U870 Cluster: Drug resistance transporter, EmrB/QacA ... 38 0.46
UniRef50_A6RK53 Cluster: Putative uncharacterized protein; n=1; ... 38 0.46
UniRef50_O28944 Cluster: Multidrug resistance protein; n=1; Arch... 38 0.46
UniRef50_A7I7E2 Cluster: Major facilitator superfamily MFS_1; n=... 38 0.46
UniRef50_A2SRE0 Cluster: Major facilitator superfamily MFS_1; n=... 38 0.46
UniRef50_A0RU05 Cluster: Permease of the major facilitator super... 38 0.46
UniRef50_O06473 Cluster: Multidrug efflux protein yfmO; n=19; Ba... 38 0.46
UniRef50_Q1EUU6 Cluster: Major facilitator superfamily MFS_1; n=... 38 0.61
UniRef50_A7HM59 Cluster: Major facilitator superfamily MFS_1; n=... 38 0.61
UniRef50_A6DCZ0 Cluster: Putative MFS metabolite transporter; n=... 38 0.61
UniRef50_A5N1Q2 Cluster: Predicted permease; n=1; Clostridium kl... 38 0.61
UniRef50_A0LW56 Cluster: Major facilitator superfamily MFS_1; n=... 38 0.61
UniRef50_A2T9T6 Cluster: SecY-independent transporter protein; n... 38 0.61
UniRef50_A0D3V9 Cluster: Chromosome undetermined scaffold_37, wh... 38 0.61
UniRef50_Q8ZVA8 Cluster: Drug resistance protein, conjectural; n... 38 0.61
UniRef50_Q0W6V9 Cluster: Putative permease; n=1; uncultured meth... 38 0.61
UniRef50_Q9B6C8 Cluster: NADH-ubiquinone oxidoreductase chain 2;... 38 0.61
UniRef50_UPI000023D093 Cluster: hypothetical protein FG02457.1; ... 37 0.81
UniRef50_Q97TH0 Cluster: Permease, MDR related; n=5; Clostridial... 37 0.81
UniRef50_Q73LC4 Cluster: Putative uncharacterized protein; n=1; ... 37 0.81
UniRef50_Q7D0K3 Cluster: AGR_C_1532p; n=4; Rhizobium/Agrobacteri... 37 0.81
UniRef50_Q0C1P1 Cluster: Major facilitator family transporter; n... 37 0.81
UniRef50_A7HJU1 Cluster: Major facilitator superfamily MFS_1; n=... 37 0.81
UniRef50_A0LEE5 Cluster: Major facilitator superfamily MFS_1; n=... 37 0.81
UniRef50_A3H739 Cluster: Major facilitator superfamily MFS_1; n=... 37 0.81
UniRef50_UPI0000499E89 Cluster: major facilitator superfamily pr... 37 1.1
UniRef50_Q88U53 Cluster: Multidrug transport protein, major faci... 37 1.1
UniRef50_Q81UW3 Cluster: Major facilitator family transporter; n... 37 1.1
UniRef50_Q47P50 Cluster: Drug resistance transporter Bcr/CflA su... 37 1.1
UniRef50_Q30P28 Cluster: Major facilitator superfamily MFS_1; n=... 37 1.1
UniRef50_Q0IBM3 Cluster: Transporter, major facilitator family p... 37 1.1
UniRef50_A4SRL1 Cluster: Major facilitator superfamily permease;... 37 1.1
UniRef50_A4F7E6 Cluster: Drug resistance transporter, Bcr/CflA f... 37 1.1
UniRef50_Q9XMS0 Cluster: NADH-ubiquinone oxidoreductase chain 5;... 37 1.1
UniRef50_Q6BL04 Cluster: Similar to CA2053|IPF11029 Candida albi... 37 1.1
UniRef50_Q4WJ43 Cluster: Tetracycline transporter, putative; n=1... 37 1.1
UniRef50_Q97C78 Cluster: Putative uncharacterized protein TVG023... 37 1.1
UniRef50_P25351 Cluster: Uncharacterized membrane protein YCR023... 37 1.1
UniRef50_UPI00015BAF50 Cluster: major facilitator superfamily MF... 36 1.4
UniRef50_UPI0000D56B97 Cluster: PREDICTED: similar to CG9864-PA;... 36 1.4
UniRef50_Q5HD42 Cluster: Transporter, putative; n=16; Staphyloco... 36 1.4
UniRef50_Q4KGW4 Cluster: Drug transporter, putative; n=1; Pseudo... 36 1.4
UniRef50_Q38ZV9 Cluster: Major facilitator superfamily (MFS_1) t... 36 1.4
UniRef50_P70952 Cluster: Putaive orf protein; n=1; Bacillus subt... 36 1.4
UniRef50_O32182 Cluster: YusP protein; n=13; Bacillus|Rep: YusP ... 36 1.4
UniRef50_Q9X7L7 Cluster: ABC transporter; n=6; Alphaproteobacter... 36 1.4
UniRef50_A6T4B1 Cluster: Transporter of the MFS superfamily; n=1... 36 1.4
UniRef50_A5N066 Cluster: Putative uncharacterized protein; n=1; ... 36 1.4
UniRef50_A1VG65 Cluster: Major facilitator superfamily MFS_1 pre... 36 1.4
UniRef50_Q4N3Z0 Cluster: Cation-transporting ATPase; n=1; Theile... 36 1.4
UniRef50_Q9HRX5 Cluster: Multidrug resistance protein homolog; n... 36 1.4
UniRef50_A2BLY7 Cluster: Predicted permease; n=1; Hyperthermus b... 36 1.4
UniRef50_UPI00006CD0ED Cluster: hypothetical protein TTHERM_0012... 36 1.9
UniRef50_Q8YJH9 Cluster: GLUCARATE TRANSPORTER; n=6; Brucella|Re... 36 1.9
UniRef50_Q8D526 Cluster: ABC-type dipeptide/oligopeptide/nickel ... 36 1.9
UniRef50_Q7NTU5 Cluster: D-galactonate transporter; n=4; Bacteri... 36 1.9
UniRef50_Q83X84 Cluster: Putative efflux transporter protein; n=... 36 1.9
UniRef50_Q0TUY0 Cluster: Drug resistance transporter, EmrB/QacA ... 36 1.9
UniRef50_A0JZZ8 Cluster: Drug resistance transporter, Bcr/CflA s... 36 1.9
UniRef50_A0HDC9 Cluster: Major facilitator superfamily MFS_1; n=... 36 1.9
UniRef50_Q697G7 Cluster: NADH-ubiquinone oxidoreductase chain 2;... 36 1.9
UniRef50_Q24E61 Cluster: Major Facilitator Superfamily protein; ... 36 1.9
UniRef50_A7RY34 Cluster: Predicted protein; n=1; Nematostella ve... 36 1.9
UniRef50_A4VED3 Cluster: Putative uncharacterized protein; n=1; ... 36 1.9
UniRef50_A4QQH1 Cluster: Putative uncharacterized protein; n=2; ... 36 1.9
UniRef50_Q82AY8 Cluster: Putative bicyclomycin resistance protei... 36 2.5
UniRef50_Q7M9C7 Cluster: PUTATIVE EFFLUX PROTEIN; n=1; Wolinella... 36 2.5
UniRef50_P74491 Cluster: Slr1935 protein; n=3; Chroococcales|Rep... 36 2.5
UniRef50_Q9F4G1 Cluster: TcaB; n=30; Staphylococcus|Rep: TcaB - ... 36 2.5
UniRef50_A6T2X4 Cluster: Transporter of the MFS superfamily; n=1... 36 2.5
UniRef50_A0YA61 Cluster: Major facilitator (MFS) superfamily pro... 36 2.5
UniRef50_Q015B0 Cluster: Diphthamide biosynthesis protein; n=3; ... 36 2.5
UniRef50_Q869U5 Cluster: Similar to Xanthomonas campestris (Pv. ... 36 2.5
UniRef50_Q97BD2 Cluster: Multidrug resistance protein; n=2; Ther... 36 2.5
UniRef50_P40760 Cluster: Uncharacterized MFS-type transporter yu... 36 2.5
UniRef50_Q9RYU8 Cluster: Peptide ABC transporter, permease prote... 35 3.3
UniRef50_Q98G41 Cluster: Sn-glycerol-3-phosphate transport syste... 35 3.3
UniRef50_Q8Y3Q6 Cluster: Lmo2777 protein; n=11; Listeria|Rep: Lm... 35 3.3
UniRef50_Q74J65 Cluster: Major facilitator superfamily permease;... 35 3.3
UniRef50_Q74D84 Cluster: Peptide ABC transporter, permease prote... 35 3.3
UniRef50_Q5QXJ1 Cluster: Predicted permease; n=2; Idiomarina|Rep... 35 3.3
UniRef50_Q3IKK7 Cluster: Putative L-arabinose/isopropyl-beta-D-t... 35 3.3
UniRef50_Q18A12 Cluster: Probable transporter; n=2; Clostridium ... 35 3.3
UniRef50_Q0BM64 Cluster: Possible MFS family major facilitator t... 35 3.3
UniRef50_Q02Z05 Cluster: Permease of the major facilitator super... 35 3.3
UniRef50_A4XC85 Cluster: Major facilitator superfamily MFS_1; n=... 35 3.3
UniRef50_A3I8X0 Cluster: Putative uncharacterized protein; n=2; ... 35 3.3
UniRef50_A0EF24 Cluster: Chromosome undetermined scaffold_92, wh... 35 3.3
UniRef50_Q5API4 Cluster: Potential transporter; n=4; Saccharomyc... 35 3.3
UniRef50_Q0UH31 Cluster: Putative uncharacterized protein; n=1; ... 35 3.3
UniRef50_A4R5S1 Cluster: Putative uncharacterized protein; n=1; ... 35 3.3
UniRef50_A4QR30 Cluster: Putative uncharacterized protein; n=3; ... 35 3.3
UniRef50_Q980D8 Cluster: Na(+)/H(+) antiporter; n=1; Sulfolobus ... 35 3.3
UniRef50_Q4J6Z9 Cluster: Conserved membrane protein; n=5; Sulfol... 35 3.3
UniRef50_A3H6E0 Cluster: Major facilitator superfamily MFS_1; n=... 35 3.3
UniRef50_UPI00003C85A7 Cluster: hypothetical protein Faci_030001... 35 4.3
UniRef50_Q81VG2 Cluster: Major facilitator family transporter; n... 35 4.3
UniRef50_Q5YU78 Cluster: Putative transporter; n=2; Actinomyceta... 35 4.3
UniRef50_Q30UP2 Cluster: Histidine kinase; n=1; Thiomicrospira d... 35 4.3
UniRef50_Q2CJ19 Cluster: Probable transporter, Major facilitator... 35 4.3
UniRef50_Q1WVC5 Cluster: Multidrug resistance protein B; n=1; La... 35 4.3
UniRef50_Q1ATX5 Cluster: Drug resistance transporter EmrB/QacA s... 35 4.3
UniRef50_Q189M4 Cluster: Probable transporter; n=3; Clostridium ... 35 4.3
UniRef50_Q0TSM6 Cluster: Putative polysaccharide polymerase prot... 35 4.3
UniRef50_A7HNZ9 Cluster: Drug resistance transporter, Bcr/CflA s... 35 4.3
UniRef50_A7CWG7 Cluster: Drug resistance transporter, Bcr/CflA s... 35 4.3
UniRef50_A6WBK3 Cluster: Drug:proton antiporter; n=1; Kineococcu... 35 4.3
UniRef50_A6CHJ5 Cluster: Putative uncharacterized protein; n=1; ... 35 4.3
UniRef50_A5UW78 Cluster: Drug resistance transporter, EmrB/QacA ... 35 4.3
UniRef50_A3IE50 Cluster: Putative uncharacterized protein; n=1; ... 35 4.3
UniRef50_Q9VPE0 Cluster: CG18281-PA; n=2; Drosophila melanogaste... 35 4.3
UniRef50_Q94886 Cluster: Na(+)-dependent inorganic phosphate cot... 35 4.3
UniRef50_Q21044 Cluster: Putative uncharacterized protein; n=3; ... 35 4.3
UniRef50_Q4W9H7 Cluster: MFS myo-inositol transporter, putative;... 35 4.3
UniRef50_A3LPQ4 Cluster: Monocarboxylate permease homolog; n=4; ... 35 4.3
UniRef50_A2R4U7 Cluster: Contig An15c0090, complete genome; n=11... 35 4.3
UniRef50_A2Q7P8 Cluster: Contig An01c0070, complete genome; n=2;... 35 4.3
UniRef50_Q0W0F5 Cluster: Putative permease; n=1; uncultured meth... 35 4.3
UniRef50_Q45632 Cluster: Maltose permease; n=3; Geobacillus|Rep:... 35 4.3
UniRef50_UPI00015C60EE Cluster: hypothetical protein CKO_04291; ... 34 5.7
UniRef50_UPI000155657C Cluster: PREDICTED: similar to novel solu... 34 5.7
UniRef50_Q81QS2 Cluster: Major facilitator family transporter; n... 34 5.7
UniRef50_Q41GF5 Cluster: Repeat unit transporter; n=1; Exiguobac... 34 5.7
UniRef50_Q1V9Z1 Cluster: Putative sugar transport protein; n=1; ... 34 5.7
UniRef50_Q18X02 Cluster: Major facilitator superfamily MFS_1; n=... 34 5.7
UniRef50_Q18S15 Cluster: Major facilitator superfamily MFS_1 pre... 34 5.7
UniRef50_Q12DS4 Cluster: Major facilitator superfamily MFS_1; n=... 34 5.7
UniRef50_Q027J7 Cluster: Major facilitator superfamily MFS_1; n=... 34 5.7
UniRef50_A6LKJ1 Cluster: Putative uncharacterized protein; n=1; ... 34 5.7
UniRef50_A6AMT3 Cluster: Transporter, major facilitator family; ... 34 5.7
UniRef50_A5D123 Cluster: Hypothetical membrane protein; n=1; Pel... 34 5.7
UniRef50_A4FMT7 Cluster: Multidrug resistance efflux protein; n=... 34 5.7
UniRef50_A4C790 Cluster: Predicted signal transduction protein c... 34 5.7
UniRef50_A4BBC6 Cluster: Putative transmembrane efflux protein; ... 34 5.7
UniRef50_A3I6W0 Cluster: Blt; n=1; Bacillus sp. B14905|Rep: Blt ... 34 5.7
UniRef50_A0L9X7 Cluster: Major facilitator superfamily MFS_1; n=... 34 5.7
UniRef50_A7SX51 Cluster: Predicted protein; n=1; Nematostella ve... 34 5.7
UniRef50_Q97CH7 Cluster: Metabolite transporter; n=8; Thermoplas... 34 5.7
UniRef50_A3DPA6 Cluster: Major facilitator superfamily MFS_1; n=... 34 5.7
UniRef50_Q5HH70 Cluster: Uncharacterized MFS-type transporter SA... 34 5.7
UniRef50_Q9ZD69 Cluster: Putative transporter ampG 1; n=5; Ricke... 34 5.7
UniRef50_UPI0000E4677C Cluster: PREDICTED: similar to solute car... 34 7.5
UniRef50_Q9KBY6 Cluster: BH1788 protein; n=1; Bacillus haloduran... 34 7.5
UniRef50_Q4J4D6 Cluster: Drug resistance transporter Bcr/CflA su... 34 7.5
UniRef50_Q3W7R1 Cluster: Drug resistance transporter EmrB/QacA s... 34 7.5
UniRef50_Q3MQ51 Cluster: Chloramphenicol/florfenicol exporter; n... 34 7.5
UniRef50_Q1GI74 Cluster: Major facilitator superfamily MFS_1; n=... 34 7.5
UniRef50_Q1AYE3 Cluster: Drug resistance transporter EmrB/QacA s... 34 7.5
UniRef50_O32783 Cluster: Multidrug transporter; n=1; Lactococcus... 34 7.5
UniRef50_A6PGE8 Cluster: Putative uncharacterized protein; n=2; ... 34 7.5
UniRef50_A5KS25 Cluster: Major facilitator superfamily MFS_1 pre... 34 7.5
UniRef50_A5KF37 Cluster: Transmembrane transport protein; n=7; C... 34 7.5
UniRef50_A4M9X2 Cluster: Putative uncharacterized protein; n=1; ... 34 7.5
UniRef50_A4ANG8 Cluster: MFS permease; n=2; Flavobacteriales|Rep... 34 7.5
UniRef50_A2U3U4 Cluster: Major facilitator family transporter; n... 34 7.5
UniRef50_A1SY00 Cluster: Transporter major facilitator superfami... 34 7.5
UniRef50_A0JUL5 Cluster: Drug resistance transporter, Bcr/CflA s... 34 7.5
UniRef50_Q9VEW8 Cluster: CG17929-PA; n=1; Drosophila melanogaste... 34 7.5
UniRef50_A4UAI4 Cluster: NADH dehydrogenase subunit 6; n=1; Bomb... 34 7.5
UniRef50_A2ELP0 Cluster: Putative uncharacterized protein; n=1; ... 34 7.5
UniRef50_Q5AX13 Cluster: Putative uncharacterized protein; n=1; ... 34 7.5
UniRef50_Q0TZE2 Cluster: Putative uncharacterized protein; n=1; ... 34 7.5
UniRef50_Q6KZC3 Cluster: Permease; n=2; Thermoplasmatales|Rep: P... 34 7.5
UniRef50_P37482 Cluster: Uncharacterized transporter yycB; n=2; ... 34 7.5
UniRef50_O52717 Cluster: Ribitol transporter; n=11; Bacteria|Rep... 34 7.5
UniRef50_Q668K2 Cluster: Putative sialic acid transporter; n=39;... 34 7.5
UniRef50_UPI00015B4D7D Cluster: PREDICTED: similar to sodium-dep... 33 10.0
UniRef50_UPI0001597403 Cluster: YitZ; n=1; Bacillus amyloliquefa... 33 10.0
UniRef50_UPI0000E4722E Cluster: PREDICTED: hypothetical protein;... 33 10.0
UniRef50_UPI0000DADEBA Cluster: drug resistance transporter, Bcr... 33 10.0
UniRef50_UPI0000D56C64 Cluster: PREDICTED: similar to CG5304-PA;... 33 10.0
UniRef50_Q987Z4 Cluster: Mlr6842 protein; n=1; Mesorhizobium lot... 33 10.0
UniRef50_Q8R7Z6 Cluster: Putative uncharacterized protein; n=2; ... 33 10.0
UniRef50_Q7U8B5 Cluster: Possible multidrug efflux transporter, ... 33 10.0
UniRef50_Q6F832 Cluster: Putative transport protein; n=2; Acinet... 33 10.0
UniRef50_Q6AB23 Cluster: Putative sugar transporter; n=1; Propio... 33 10.0
UniRef50_P72824 Cluster: Sll1200 protein; n=1; Synechocystis sp.... 33 10.0
UniRef50_O07569 Cluster: Putative uncharacterized protein yhjO; ... 33 10.0
UniRef50_Q9Z9P3 Cluster: YhcA; n=2; Bacillus halodurans|Rep: Yhc... 33 10.0
UniRef50_Q7D7B2 Cluster: Drug transporter; n=9; Mycobacterium|Re... 33 10.0
UniRef50_Q3CEE0 Cluster: Conserved domain protein; n=3; Thermoan... 33 10.0
UniRef50_Q2FD93 Cluster: Dihydrofolate reductase X; n=3; Acineto... 33 10.0
UniRef50_Q1DG35 Cluster: Drug resistance transporter, EmrB/QacA ... 33 10.0
UniRef50_Q0LQB1 Cluster: Major facilitator superfamily MFS_1; n=... 33 10.0
UniRef50_Q03XU0 Cluster: Permease of the major facilitator super... 33 10.0
UniRef50_A6W152 Cluster: Major facilitator superfamily MFS_1 pre... 33 10.0
UniRef50_A6DTB4 Cluster: Ferrochelatase; n=1; Lentisphaera arane... 33 10.0
UniRef50_A6AM04 Cluster: Sulfatase domain protein; n=1; Vibrio h... 33 10.0
UniRef50_A5H8A5 Cluster: Plasmid efflux fluoroquinolone; n=3; Ba... 33 10.0
UniRef50_A4JNP2 Cluster: Major facilitator superfamily MFS_1; n=... 33 10.0
UniRef50_A4J1M4 Cluster: Major facilitator superfamily MFS_1; n=... 33 10.0
UniRef50_A0H9U1 Cluster: Major facilitator superfamily MFS_1; n=... 33 10.0
UniRef50_Q54RT0 Cluster: Putative uncharacterized protein; n=1; ... 33 10.0
UniRef50_Q4FWJ2 Cluster: Transporter-like protein; n=3; Leishman... 33 10.0
UniRef50_Q09F96 Cluster: Ymf77; n=1; Tetrahymena malaccensis|Rep... 33 10.0
UniRef50_A6MI51 Cluster: Putative uncharacterized protein; n=1; ... 33 10.0
UniRef50_Q2UPC1 Cluster: Predicted transporter; n=2; Aspergillus... 33 10.0
UniRef50_Q1DLF2 Cluster: Putative uncharacterized protein; n=1; ... 33 10.0
UniRef50_Q0UAB0 Cluster: Putative uncharacterized protein; n=1; ... 33 10.0
UniRef50_Q0W0H1 Cluster: Putative permease; n=1; uncultured meth... 33 10.0
UniRef50_A7IAW9 Cluster: Multi-sensor signal transduction histid... 33 10.0
UniRef50_P94131 Cluster: Cis,cis-muconate transport protein; n=1... 33 10.0
>UniRef50_UPI0000D573B2 Cluster: PREDICTED: similar to tumor
suppressing subtransferable candidate 5; n=1; Tribolium
castaneum|Rep: PREDICTED: similar to tumor suppressing
subtransferable candidate 5 - Tribolium castaneum
Length = 420
Score = 240 bits (588), Expect = 4e-62
Identities = 126/399 (31%), Positives = 210/399 (52%), Gaps = 20/399 (5%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
VDL AVGL +PL H+R++GA+H +GLL S+Y+G Q+ SGP++GS SD++ RR
Sbjct: 17 VDLFAVGLTVPLFSNHLRELGASHFTIGLLNSLYSGLQVISGPIVGSWSDVRDRRSVLQI 76
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXX------------XKQTQMLAKALVPDYENN 109
CS+ Y LGLT K TQ + KA++ D
Sbjct: 77 TLLLCSLGYVALGLTNSLLVIASVRILLVAPAHFQNRMITGVTKHTQSICKAIITDLVPP 136
Query: 110 EQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLX 169
+ A +G+ A +G +GP +GGH++E NG F + + FI N + C +
Sbjct: 137 SDR-ASAFGRSTAFGSLGFIIGPTLGGHLIE-RKNG-FFHVCLFTSVLFIINVGITCAIN 193
Query: 170 XXXXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMG 229
+ ++ L + F +S + I+W +WD+FL + + GF++
Sbjct: 194 EIKSPKKRQLNHESVPIFAK-----LGHEFNKSVRDMGEIDWGAFWDVFLLRFIFGFSVT 248
Query: 230 VYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVF 289
+Y+S ++YLK + ++ ++VGY ISF G +++ + YIN FYK DV R H F
Sbjct: 249 MYFSQQSVYLKEQFKMAQRHVGYTISFFSASGMAAAFLLHYINYFYKGDVSCLKRLTHFF 308
Query: 290 LLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSV 349
LL+++SL L + N+ +++ L+P ++ V R+V++E++LK + HRG+L G SNS+
Sbjct: 309 LLMTLSLVCLYFAPNIELFLLVLVPFSLSCTVLRIVSMELMLKNASTTHRGSLSGTSNSI 368
Query: 350 RSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMS 388
S++ V P+ +G LG S + + P ++G ++S
Sbjct: 369 MSVARFVTPVTSGLISDKLGGSSALLFTAVPPLIGTLVS 407
>UniRef50_A7RPG8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 420
Score = 180 bits (438), Expect = 6e-44
Identities = 116/391 (29%), Positives = 198/391 (50%), Gaps = 16/391 (4%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DL+ V + +PL R++GA VGL+GS+Y Q S PL+G SD+ GR+
Sbjct: 24 LDLMTVSMGLPLAARRARELGATPSIVGLIGSVYGAIQFFSNPLVGKFSDVAGRKKVLLV 83
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
AY + GL+ KQ+Q L KA + D Q+ ++GK
Sbjct: 84 SLLGTGAAYLLHGLSVSLIMLALTRIPIGLFKQSQSLCKACLADITAPAQR-ISVFGKFN 142
Query: 122 AISGVGITLGPMIGGHI-MEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
A S +G +GP+IGGH+ M DN F + + GI F+ A+ F
Sbjct: 143 AFSSLGFVVGPLIGGHLAMTDN---GFFRVFLLEGILFV---AMTIFTWLCIEHDDQQQS 196
Query: 181 XXXXDVLSENLVLSLFNSFKQSFVVLYSINWS----KYWDIFLYKALVGFAMGVYYSNYA 236
DV + + S F+ + S + S K ++ + + L+GF+M ++ SN++
Sbjct: 197 SPNKDVGTAS-ESSEFDGARNSEIQTKSGRKLQENLKIANLLIVRFLMGFSMIIFRSNFS 255
Query: 237 LYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISL 296
L+ Y+ +PK GY++SF G++G +S YF+G + +FY D +L LH +L++S+
Sbjct: 256 TVLEFRYNTTPKTNGYIMSFNGIVGGLSGYFVGNLLTFYNNDDAKAL--LHFSSILAMSI 313
Query: 297 TGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVV 356
+ S ++ V+++ PLA +AVSR+ + + LKR D +G L+G NS+ S + ++
Sbjct: 314 FCVTFSPELWVLVVFIAPLAFSSAVSRVCSTNLTLKRGRADEKGLLLGVGNSLMSFARML 373
Query: 357 APMVAGFTGQFLGVSYVIYASLAPTVLGLVM 387
+P + G Q L V S++ + +G+++
Sbjct: 374 SPTLGGL-AQELSVYAPGMLSVSVSAVGILL 403
>UniRef50_UPI00005842F8 Cluster: PREDICTED: hypothetical protein
isoform 1; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: hypothetical protein isoform 1 -
Strongylocentrotus purpuratus
Length = 408
Score = 147 bits (357), Expect = 4e-34
Identities = 101/362 (27%), Positives = 175/362 (48%), Gaps = 13/362 (3%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DL AV LIIP+ +GA+ VGL+G+IY QL S PL+G SD+ GRR
Sbjct: 17 LDLFAVALIIPVASRQATNLGASPASVGLVGTIYGILQLISAPLVGRWSDIGGRRSTLLL 76
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
S+ Y +GL+ K + + +A + + +Q+ A+++G
Sbjct: 77 CLFFTSIGYIFMGLSTSIVHYLLARVPLGIFKHSISITRAYLAEITPKDQR-AKVFGYFN 135
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXX 181
IS +G +GP+IGGH+ E NG F ++ + F AA F+
Sbjct: 136 GISSIGFIIGPLIGGHLAE-MENG-FFKVSIVTSAIF---AAWFVFVLLFMNEPQHRGLP 190
Query: 182 XXXDVLSENLVLSLFNS-FKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
V ++ FN+ F S I S + ++F + L GF+ ++ SN+ L L+
Sbjct: 191 NTKSV--QDFTGGEFNNKFPSSLQTFKEIIKSGH-ELFFIRFLQGFSATLFRSNFTLSLE 247
Query: 241 TTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLI 300
+D +P G +ISF + ++ + +G + FY + H L I+L LI
Sbjct: 248 QKFDSTPIITGRIISFGSIASALCALGVGRLVQFYG---NMPRLYFHSCTLRIIALVLLI 304
Query: 301 VSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMV 360
++ N+ +++++ L MGN+V+R+ + + ++R + G L+G + SV S+ V+P++
Sbjct: 305 LAPNIPSFLVFYFLLCMGNSVARICSTNLSIERGKVEDAGALLGLNQSVMSICRTVSPLI 364
Query: 361 AG 362
AG
Sbjct: 365 AG 366
>UniRef50_Q8NBP5 Cluster: Major facilitator superfamily
domain-containing protein 9; n=15; Amniota|Rep: Major
facilitator superfamily domain-containing protein 9 -
Homo sapiens (Human)
Length = 474
Score = 133 bits (322), Expect = 7e-30
Identities = 103/380 (27%), Positives = 174/380 (45%), Gaps = 22/380 (5%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DL V +++PL+ HV+ +GA+ G++GS Y QL S L+G SD+ GRR
Sbjct: 55 LDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLA 114
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
++ Y +LG K T +++AL+ D E+++ + G
Sbjct: 115 CILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSISRALLSDVVP-EKERPLVIGHFN 173
Query: 122 AISGVGITLGPMIGGHIMEDNPN---GAFM-FIAFIV--GICFIF---NAALVCFLXXXX 172
SGVG LGP++GG++ E AF+ F+ FI+ G+ + F A
Sbjct: 174 TASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPWREAKPGSTEKGLP 233
Query: 173 XXXXXXXXXXXXDVLSENLVLSLFNSFKQSF-----VVLYSIN-----WSKYWDIFLYKA 222
D + E + K++ VVL N +S+ WDIFL +
Sbjct: 234 LRKTHVLLGRSHDTVQEAATSRRARASKKTAQPWVEVVLALRNMKNLLFSEMWDIFLVRL 293
Query: 223 LVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYS 282
L+ A+ +YYSN+ L L+ + + PK GY+IS+ ++G+++ +G I YK +
Sbjct: 294 LMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQAL 353
Query: 283 LRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTL 342
L LH +L L ++ + V+ L+ A+ R ++ L GTL
Sbjct: 354 L--LHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTL 411
Query: 343 IGASNSVRSLSGVVAPMVAG 362
IG SV ++ ++AP+++G
Sbjct: 412 IGVGQSVTAVGRIIAPLLSG 431
>UniRef50_UPI0000D5728F Cluster: PREDICTED: hypothetical protein;
n=1; Tribolium castaneum|Rep: PREDICTED: hypothetical
protein - Tribolium castaneum
Length = 271
Score = 131 bits (317), Expect = 3e-29
Identities = 83/282 (29%), Positives = 130/282 (46%), Gaps = 15/282 (5%)
Query: 114 AEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXX 173
A IY +M AI G+ G +IGGH+ E + NG F ++ N AL+C +
Sbjct: 2 AAIY-RMQAIGGIAFISGALIGGHLSE-HANG-FRITFALISTMVAVNFALICLIPDVHT 58
Query: 174 XXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYS 233
L + K + L +NW KYWD+F K +V F M V
Sbjct: 59 TEKKAVPT-----------LQIATELKNAAANLTKVNWPKYWDLFTMKLIVDFVMNVMQF 107
Query: 234 NYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYIN-SFYKKDVDYSLRSLHVFLLL 292
N L L+ + +S K GYV + V+ +S + S YK D+ R H FLLL
Sbjct: 108 NLGLILQQRFGVSGKLFGYVFAIASVVSIATSLAMSKAQKSLYKNDISGLQRLKHGFLLL 167
Query: 293 SISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSL 352
++ GL +S NV + ++L+P ++ + E++L R+ +G+++G + SL
Sbjct: 168 MLACLGLGLSPNVILFCLFLMPTSVTRVLFESTFTEIILARASPQEKGSIMGTFETTLSL 227
Query: 353 SGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTK 394
G+ AP+++G F G Y I P VLG + Y ++K
Sbjct: 228 GGLTAPLISGIVSDFWGEMYCILMCAVPLVLGTGLIYLQKSK 269
>UniRef50_A7HKI1 Cluster: Major facilitator superfamily MFS_1; n=1;
Fervidobacterium nodosum Rt17-B1|Rep: Major facilitator
superfamily MFS_1 - Fervidobacterium nodosum Rt17-B1
Length = 407
Score = 99.1 bits (236), Expect = 2e-19
Identities = 89/372 (23%), Positives = 165/372 (44%), Gaps = 27/372 (7%)
Query: 3 DLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXX 62
D+L GLIIPL+P + ++ GA I +G L IY Q+ + PLIG +SD GR+
Sbjct: 28 DMLGFGLIIPLLPYYAKEFGAKDIVIGFLSMIYPLGQIFASPLIGRMSDKFGRKIALLLS 87
Query: 63 XXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAA 122
++ +LG +A++ + D+ +++ +A+ G + A
Sbjct: 88 VGGTFLSLLLLGFAKSLTLIFISRLLDGLTGGNITVAQSYISDF-TDKKSRAKSLGLIGA 146
Query: 123 ISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXX 182
G+G LGP IGG + + G + F G+ F+ N + FL
Sbjct: 147 AFGLGFILGPAIGGFL---SRWGFHVPAFFAAGLSFV-NLLNIIFL-----------LPD 191
Query: 183 XXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTT 242
V V F K+ +I+ + + L K F + S +AL+
Sbjct: 192 SKPVEDAKRVPFTFEEMKK------TISRPVVFYLLLTKFFYSFGFTTFESTFALFALRR 245
Query: 243 YDLSPKYVGYVISFQGVMGSIS-SYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIV 301
+L +V+++ G++ + + + +G I YK+D D ++SL +F+++ L
Sbjct: 246 LNLPLSQTSFVLAYVGILIAFTQGFLVGKITKKYKED-DI-IKSL-IFVVVPF-LILYSF 301
Query: 302 SINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVA 361
S N+ ++ L PL++ + + + + K + D G +G NSV SL+ +++P+
Sbjct: 302 SANLITLILLLTPLSVISGLIGVSVNSIATKTVERDRLGGTLGIFNSVDSLTRIISPLFG 361
Query: 362 GFTGQFLGVSYV 373
Q++G Y+
Sbjct: 362 ALIIQYIGPKYL 373
>UniRef50_Q4S0N3 Cluster: Chromosome 2 SCAF14781, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 2
SCAF14781, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 437
Score = 94.7 bits (225), Expect = 4e-18
Identities = 46/162 (28%), Positives = 89/162 (54%), Gaps = 2/162 (1%)
Query: 206 LYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISS 265
++++ S WD+FL + L+ A+ +YYSN++L ++ + L PK GY+IS+ +G++S
Sbjct: 256 IHTVASSDMWDLFLVRLLMAIAIMLYYSNFSLAMEERFSLKPKVTGYLISYSSTLGALSG 315
Query: 266 YFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLV 325
+ +G + Y ++ L LH +L + + +V+ ++ ++ + R
Sbjct: 316 FLVGPVTQLYGNNMPTLL--LHSTVLTCSLIFMYAAAASVWQVLLTSTFFSISTNIGRTC 373
Query: 326 TLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQF 367
++ L+R GTLIGA SV S+ +VAP+++G T +F
Sbjct: 374 VTDLELQRGGLQASGTLIGAGQSVTSVGRIVAPLLSGLTQEF 415
Score = 83.4 bits (197), Expect = 9e-15
Identities = 53/173 (30%), Positives = 80/173 (46%), Gaps = 10/173 (5%)
Query: 3 DLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXX 62
DL V +I+PL+ HV+ +GA G++GS Y QL S ++GS SD+ GRR
Sbjct: 6 DLFGVSMIVPLLSHHVKSLGAGPTVAGIVGSTYGILQLFSSTVVGSWSDVVGRRYSLLTC 65
Query: 63 XXXCSVAYTVLGLTXXXXXXXXXX-------XXXXXXKQTQMLAKALVPDYENNEQKQAE 115
++ Y +LG++ K + + +AL+ D E ++
Sbjct: 66 LLSSALGYILLGMSTSIALFVLARIPVGRFWTPGGLFKHSLSICRALLSDLV-AESERPL 124
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFL 168
+ G A S VG LGP++GG++ E G F +F FI NA LV L
Sbjct: 125 VMGHFNAASSVGFILGPVVGGYLTEQ--EGGFYTSSFTCAAIFIINAGLVWML 175
>UniRef50_UPI000038DC0A Cluster: COG0477: Permeases of the major
facilitator superfamily; n=1; Nostoc punctiforme PCC
73102|Rep: COG0477: Permeases of the major facilitator
superfamily - Nostoc punctiforme PCC 73102
Length = 406
Score = 89.8 bits (213), Expect = 1e-16
Identities = 95/391 (24%), Positives = 158/391 (40%), Gaps = 23/391 (5%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DLL G+I+P++P + + GA LL +IY+ Q PL G SD GRR
Sbjct: 19 IDLLGFGIILPILPLYAEQFGAKPNEATLLVAIYSLMQFLFAPLWGRFSDRYGRRPILLL 78
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
+AY LG A+A + D +A G +
Sbjct: 79 TLFGSVIAYAGLGFANSLWMLFLARSLAGIMAGNISTAQAYIADI-TTPANRARGMGIIG 137
Query: 122 AISGVGITLGPMIGGHIMEDNPNGA-FMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
A G+G LGP IGG ++ +P+ A F + G +F AL+C L
Sbjct: 138 AAFGLGFILGPAIGGFLIGSDPDNANFHLPSLFSGGLSLF--ALLCALTLLPESLNSETK 195
Query: 181 XXXXDVLSENLVLSLFN-SFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYL 239
L+L S + F VL I + V FA+ S AL+
Sbjct: 196 AKMQANRHRRRRLNLLQLSQRPQFCVLVGIYF-----------FVTFAVAAMDSTLALWS 244
Query: 240 KTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDV-DYSLRSLHVF-LLLSISLT 297
K + P+ Y+ +F G++ +I G + F KK + L +L + L L + L
Sbjct: 245 KQQLNWGPQQTSYLFAFMGIVSTIVQ---GGLIGFLKKHFGEIKLLTLGILGLGLGLLLI 301
Query: 298 GLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVA 357
G S+ + L+ A G +VS+ + ++ + + + +G ++G ++S +L+ +V
Sbjct: 302 GFSQSLILLLVATTLV--AWGISVSQPILNSLISQMTAPEEQGQILGIASSCSALARIVG 359
Query: 358 PMVAGFTGQFLGVSYVIYASLAPTVLGLVMS 388
P AG + G + ++ L +S
Sbjct: 360 PTWAGISFMKFGSDSPFLSGFLVMIVALALS 390
>UniRef50_Q9KDN7 Cluster: Multidrug-efflux transporter; n=1;
Bacillus halodurans|Rep: Multidrug-efflux transporter -
Bacillus halodurans
Length = 399
Score = 89.4 bits (212), Expect = 1e-16
Identities = 85/387 (21%), Positives = 162/387 (41%), Gaps = 31/387 (8%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
V ++ +GL+IP++P ++ GA+ + +GLL +I++ Q P G LSD GR+
Sbjct: 18 VVMMGIGLVIPILPYYIEAFGASSVELGLLIAIFSFMQFLLAPFWGRLSDKVGRKPLIAV 77
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
+VA + M A +E+K+ G +
Sbjct: 78 GMFGFAVAEFIFAFATQFWMLFVSRILAGAFGSAVMPAAMAYVSDRTSEEKRGHGMGLLG 137
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXX 181
A +GI +GP IGG + E + F+F F IF+ +
Sbjct: 138 ASMALGIVVGPGIGGWLAEFSLATPFLFAGFAASFAAIFSLLWL--------PESLPLEK 189
Query: 182 XXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKT 241
+V N + ++ + + L +FL L F + + + + ++
Sbjct: 190 RKTEVEPVNQFVQMWQAVRSPIGFL----------LFLVFGL-SFGLANFQTIFGIFALH 238
Query: 242 TYDLSPKYVGYVISFQGVMGSIS-SYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLI 300
+ +P VG+++ G++G+I+ +G + Y ++ L SL L I ++
Sbjct: 239 RFHYNPSEVGFIMVLTGIVGAIAQGSLVGRLTERYGEE-KVVLGSLS---LSGIGFLIMM 294
Query: 301 VSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMV 360
++ N + + +GN++ R ++ L + GD +G ++G +NS+ SL VV ++
Sbjct: 295 LAFNYWTVIATTCLFFLGNSILR-PAVQSFLSKMAGDQQGMIMGLNNSILSLGNVVGALL 353
Query: 361 AGFT---GQFLGV---SYVIYASLAPT 381
AG FL ++V++ASL T
Sbjct: 354 AGLLFEWNMFLPYTVGAFVMFASLGAT 380
>UniRef50_A7NRD2 Cluster: Major facilitator superfamily MFS_1; n=2;
Chloroflexaceae|Rep: Major facilitator superfamily MFS_1
- Roseiflexus castenholzii DSM 13941
Length = 416
Score = 87.8 bits (208), Expect = 4e-16
Identities = 88/385 (22%), Positives = 161/385 (41%), Gaps = 13/385 (3%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
VDL+ G+I+PL+P +V+++ VG+L YA Q GP++GSLSD GRR
Sbjct: 26 VDLVGYGMIVPLLPFYVQRVAPGATLVGILSGFYAMAQFLVGPMLGSLSDRFGRRPVLIA 85
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
S+AY +L + +A+A + D ++A G +
Sbjct: 86 CLSGTSLAYLLLAIADSLPLLVLALFIDGVTGGNLSIAQASIAD-STTPDRRARGLGLIG 144
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXX 181
A G+G+ +GP+IGG + N + + + + +F AL
Sbjct: 145 AAFGLGLMVGPVIGGVLSLTNLSAPALVASMLAFANTLF--ALAALPESLPPERRRLIPL 202
Query: 182 XXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKT 241
++VL + N V+L + + + + L+ A YSN+ L+
Sbjct: 203 DSAKPSHWSMVLRVANPLANLIVLLRIVTIRR---VLMVVVLLNLAFSGLYSNFPLFTAA 259
Query: 242 TYDLSPKYVGYVISFQGVMG-SISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLI 300
+ +F G+ + +G + + D + R + ++ ++ TGL
Sbjct: 260 RFGWGMFENALFFAFVGICAVTTQGLLLGRMQR-WLGDARLA-RVGMIVMVCALLATGLA 317
Query: 301 VSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMV 360
+ + + LI G A+ L +L + L+ S D +G L+G + ++ +L+ + P+V
Sbjct: 318 SAAWMLYPSVGLIAFGSGLAIPALTSL-LSLQVSPAD-QGRLMGGTAALLNLTMIAGPVV 375
Query: 361 AGFTGQFLGVS--YVIYASLAPTVL 383
AG + G + Y+I A L L
Sbjct: 376 AGISFDRAGTAAPYLIGALLGSAAL 400
>UniRef50_Q8DMH7 Cluster: Multidrug-efflux transporter; n=2;
Cyanobacteria|Rep: Multidrug-efflux transporter -
Synechococcus elongatus (Thermosynechococcus elongatus)
Length = 403
Score = 82.2 bits (194), Expect = 2e-14
Identities = 86/368 (23%), Positives = 149/368 (40%), Gaps = 26/368 (7%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
++D L LI P++P V + + + LL S +A QL + PL+G+LSD GRR
Sbjct: 17 VIDRLGESLIFPILPFFVERFNFDAFSLTLLFSAFAAAQLIAAPLLGALSDHWGRRPVLL 76
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
+V+Y + + A+A + D + +A+ +G
Sbjct: 77 ICIAGTAVSYILFAVATAPWLLFVSRIIDGLTGGVVSTAQAYIAD-TSAPANRAKNFGLT 135
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
A G+G GP IGG + + F A + + N L F+
Sbjct: 136 GAAFGIGFIFGPAIGGSLAAIDLKLPIWFAAVLA----LVNVVLAYFILPESLPAGQRSP 191
Query: 181 XXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
S+ L+LFN +++ F++ FA + S + L+LK
Sbjct: 192 LTLKSFASQQQWLALFNQRTLQALLM---------AFFIF----NFAFAGFTSIFVLFLK 238
Query: 241 TTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGL- 299
P G + GV+ +I G I S + + L SL LL++++L G+
Sbjct: 239 RQLSWGPAEAGIIFVMIGVVSTIVQ--AGLIRSLIPRFGEQCL-SLGGLLLVALALLGIA 295
Query: 300 ----IVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGV 355
+ S++V +I LA G + ++ R +G ++GAS S++S++G+
Sbjct: 296 AVPTVGSLSVPLLYACVIGLAFGVGIMLPSLRGVISNRVRDQDQGKILGASQSLQSVAGI 355
Query: 356 VAPMVAGF 363
P AG+
Sbjct: 356 AGPAWAGW 363
>UniRef50_A0GXY1 Cluster: Major facilitator superfamily MFS_1; n=1;
Chloroflexus aggregans DSM 9485|Rep: Major facilitator
superfamily MFS_1 - Chloroflexus aggregans DSM 9485
Length = 402
Score = 81.8 bits (193), Expect = 3e-14
Identities = 83/364 (22%), Positives = 152/364 (41%), Gaps = 23/364 (6%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
+VD+L GLI+PL+P V+K G N +GLLGS+YA QL + PL+G+LSD GRR
Sbjct: 15 LVDMLGYGLIMPLLPFMVQKWGGNATIIGLLGSLYALMQLLAAPLLGALSDRVGRRPVIL 74
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
++AY+ L L + +A+A + D + ++ +G +
Sbjct: 75 GCLFGSALAYSWLALADSLPLLAAAIALGGVAGSSMPVAQAYIADV-TSPTERTHGFGLL 133
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
A G+G+ G IGG + + + + +V + A+ +
Sbjct: 134 GAAFGLGLIGGAAIGGFLSQFG-----LALPPLVAATIALSNAIYASIVLPESLPPMRRH 188
Query: 181 XXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
L N F + + L + S + + L+ SN ALY
Sbjct: 189 ASS---------LPFRNLFGSALIALQA---SSVRPLLIAVMLLNITFAGLQSNIALYTL 236
Query: 241 TTYDLSPKYVGYVISFQGVMGSIS-SYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGL 299
T + P + F G+ +++ IG + S D + L + L ++G+
Sbjct: 237 TRFGWGPDQNAILFVFVGLCAALTQGVLIGKLQS-RLGDAWLASGGLGLMALAFAFVSGV 295
Query: 300 IVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPM 359
++ L+ + MG AV + +L V +++ + +G ++G ++ S++ ++ P
Sbjct: 296 YTDWLLFPLAA-LLAIGMGLAVPAITSL--VSRQAGENRQGIVLGGMQALISVALLIGPA 352
Query: 360 VAGF 363
GF
Sbjct: 353 SFGF 356
>UniRef50_Q8KDQ3 Cluster: Drug resistance protein, putative; n=10;
Chlorobiaceae|Rep: Drug resistance protein, putative -
Chlorobium tepidum
Length = 422
Score = 79.8 bits (188), Expect = 1e-13
Identities = 87/402 (21%), Positives = 165/402 (41%), Gaps = 26/402 (6%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
++DL+ G+++PL+P + +++GA+ +GL+ SIY+ Q P+ G LSD GRR
Sbjct: 14 LLDLIGFGIVLPLLPTYAKELGASPFMIGLIASIYSTMQFIFSPIWGKLSDKIGRRPVML 73
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
V+Y A+A + D +++ + + G +
Sbjct: 74 SSIFLTLVSYVFFSKAVTIPLLILARSLSGIGSANIAAAQAAITDVTDSKSRSGAM-GML 132
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
A G+G +GP++GG +M + G M F G+ FI N L FL
Sbjct: 133 GAAFGIGFIIGPLVGGVLMTN--FGISMVGLFAAGLNFI-NFTLALFLLNETNPHTEGFL 189
Query: 181 XXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYK-----ALVGFAMGVYYSNY 235
+ V+ NS S S K ++F + ++ F + N
Sbjct: 190 SLFRK--NPESVVHTNNSLFASLAHKSSAYADKIHEVFSSRPVALLMIINFIYTLAIVNM 247
Query: 236 ----ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSL-HVFL 290
L Y + + VGY+ ++ G I + + + ++ L L H+
Sbjct: 248 QVSAILLWSDVYHATEQQVGYLFAYVGFFTVIVQGVM--LPKMTRNYGEHKLMVLGHITS 305
Query: 291 LLSISLTGLIVSINVYNY-VIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSV 349
+ + I +++ + L+ A+G ++ + + M+ S +G ++G + SV
Sbjct: 306 FIGVFFIPFIPVTSLFTVGLAILLFFAIGTSLVNPLNISMISLYSYKQKQGQIMGFAQSV 365
Query: 350 RSLSGVVAPMVAGFTGQFL-GVSYVI--YASLAPTVLGLVMS 388
+L+ ++ P F+G L G + + Y + A TV+G +S
Sbjct: 366 NALARILGP----FSGSILYGYDHRMPYYVAGALTVVGTFIS 403
>UniRef50_Q9RX43 Cluster: Tetracycline-efflux transporter; n=2;
Deinococcus|Rep: Tetracycline-efflux transporter -
Deinococcus radiodurans
Length = 407
Score = 78.2 bits (184), Expect = 4e-13
Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 5/164 (3%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHI----YVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
++D++ +GLIIP++PG V+++ + ++G+L + YA Q P++G+LSD GRR
Sbjct: 19 LIDVMGIGLIIPVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRR 78
Query: 57 XXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
+ Y +L + + +A A + D E + A+
Sbjct: 79 PVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDR-AKN 137
Query: 117 YGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIF 160
+G++ A GVG LGPM+GG + E F+F A + + F++
Sbjct: 138 FGRLGATWGVGFILGPMLGGWLGEHGLRAPFLFAAGLTALNFLY 181
Score = 34.3 bits (75), Expect = 5.7
Identities = 45/174 (25%), Positives = 84/174 (48%), Gaps = 18/174 (10%)
Query: 223 LVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYS 282
L+G A V S + LY + SP G + G++ + G I+ F + +
Sbjct: 227 LLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLL--TAGVQAGLISPFIAR---FG 281
Query: 283 LRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLV--TLEMVLKRSDGD-HR 339
R + L++ +L +++S+ V++L L +G A+ L ++ ++ R G+ +
Sbjct: 282 ERRTIMTGLVASTLEFVVLSVARSAPVLYL-SLVVG-ALGGLAQPAMQGLISRQVGEQEQ 339
Query: 340 GTLIGASNSVRSLSGVVAPMV------AGFTGQFLGVSYVIYASLAPTVLGLVM 387
G ++GA S+ SL GV P++ AG F G ++V+ A L ++LG V+
Sbjct: 340 GRVMGAITSLNSLVGVFGPLLATSVFAAGQGAGFPGAAFVLGAVL--SILGTVL 391
>UniRef50_A7SCJ0 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 369
Score = 77.8 bits (183), Expect = 5e-13
Identities = 76/345 (22%), Positives = 142/345 (41%), Gaps = 23/345 (6%)
Query: 19 RKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXX 78
+K+GA+ + G L + +A QL GP+ G DL G + +++Y +L ++
Sbjct: 12 KKLGADPMVFGYLQTTFAVVQLCGGPVYGRFGDLFGSKAALGLAFSASALSYGLLSVSTS 71
Query: 79 XXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHI 138
Q ++ ++ D + E + + GK+ VG+ +GP +GG I
Sbjct: 72 VPMLFFSRLPSVFMHVMQG-SQMIITDISSKEDRAGAL-GKLGVSYAVGMVVGPFLGG-I 128
Query: 139 MEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNS 198
M + G F + V + I A ++ FL S+F+
Sbjct: 129 MTKHYGGQFAAMCSCV-LSLISVAMVMVFLPTKTKHLFHAPASST----------SVFDV 177
Query: 199 FKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQG 258
K F+ L I Y + K + G++ S +A+ + L +Y G+V+S+ G
Sbjct: 178 KK--FLELLRIPAVLY--LICIKLVSAVPFGIFQSMFAIVSMEYFKLDAQYNGFVLSYAG 233
Query: 259 VMGSI-SSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAM 317
+ + +GY++ + D D S+ ++ + + + +Y + LIPL
Sbjct: 234 TLSIVVQGIGVGYLSHRFN-DTDLLKWSIGT---IAFAYACMFMVTTIYQFCAVLIPLVA 289
Query: 318 GNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG 362
G + +VT + K GT++G S + SL V+P + G
Sbjct: 290 GGTILTIVTTSSMTKAVPIKDTGTVLGLSMACNSLVRSVSPTLGG 334
>UniRef50_Q6MQK5 Cluster: Multidrug resistance protein; n=1;
Bdellovibrio bacteriovorus|Rep: Multidrug resistance
protein - Bdellovibrio bacteriovorus
Length = 405
Score = 76.6 bits (180), Expect = 1e-12
Identities = 84/387 (21%), Positives = 156/387 (40%), Gaps = 20/387 (5%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
L+ G++IP++P R GA + GLL S+Y+ Q P G LSD GRR
Sbjct: 21 LVGFGVVIPILPILSRNFGATALETGLLLSVYSLMQFLFAPFWGRLSDRMGRRPILLFCL 80
Query: 64 XXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAI 123
+++Y + + A A + D ++ + + A
Sbjct: 81 VGETLSYIMFAWARSLEWLFVARILAGFFGASLSTASAYISDITPKHERSKGM-ALIGAA 139
Query: 124 SGVGITLGPMIGGH--IMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXX 181
G+G +GP +GG + + N A F + A +CF
Sbjct: 140 FGLGFVVGPALGGGLAVWGQHINPAPHFDTSFAS----YWVAALCF------ANFLFGVK 189
Query: 182 XXXDVLSENLVLSLFNSFKQSFVVLYS-INWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
+ LSE S + ++ F +++ +N + L AM + L++
Sbjct: 190 FLKESLSEK---SESAAKRKRFSIMWQYLNKKTVGPLMTVFLLSSLAMSSMEATLILFMG 246
Query: 241 TTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLI 300
Y K V + ++ GV+ + F+ + K + + L V LLL++ LTG+
Sbjct: 247 EKYQWDVKQVSFGFAYIGVIIIFTQGFL--VRRLLPKWGERKVLRLGV-LLLALGLTGIA 303
Query: 301 VSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMV 360
++ ++ I + L++GN ++ TL + SD + +G +G + S+ SL ++ P +
Sbjct: 304 IADSITGMAITMTLLSLGNGLANPSTLGSISLLSDANEQGAAMGVTQSMASLGRILGPAL 363
Query: 361 AGFTGQFLGVSYVIYASLAPTVLGLVM 387
G + ++ +AS LGL +
Sbjct: 364 GGALYGTVAITAPFWASGLMAFLGLAI 390
>UniRef50_Q8GR72 Cluster: Multidrug efflux pump; n=7;
Lactobacillales|Rep: Multidrug efflux pump -
Enterococcus faecalis (Streptococcus faecalis)
Length = 393
Score = 76.2 bits (179), Expect = 1e-12
Identities = 81/360 (22%), Positives = 148/360 (41%), Gaps = 21/360 (5%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
L VGL+IP++P +M + +G++ SI+A QL + P+ G LSD GR+
Sbjct: 20 LGVGLVIPVIPQLKEEMHFSGTTMGMMISIFAIAQLITSPIAGVLSDKIGRKKMIATGML 79
Query: 65 XCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQM-LAKALVPDYENNEQKQAEIYGKMAAI 123
S++ + GL M A V D ++ + AAI
Sbjct: 80 VFSISELLFGLAQAKSGFYISRGLGGIAAALLMPSVTAFVADMTTISERPKAMGLVSAAI 139
Query: 124 SGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXX 183
SG G +GP +GG I+ G FIA++ F AA + F+
Sbjct: 140 SG-GFIIGPGVGGFIIGPGVGG---FIAYLGIRAPFFAAAFLAFIGFILTLTVLKE---- 191
Query: 184 XDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTY 243
E +L+ + K SF+ + + + +F+ + F + + S Y++ +
Sbjct: 192 ----PEKRILAAVEAKKGSFMDI--LRNPMFTSLFVIILISSFGLQAFESIYSIMATINF 245
Query: 244 DLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFL-LLSISLTGLIVS 302
+ + VI+ G++ I F + ++ +K + L L F + I++ +
Sbjct: 246 GFTTSEIAIVITVSGILALICQLF--FFDAIVQKIGEMGLIQLTFFASAIFIAVIAFTKN 303
Query: 303 INVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG 362
V + +++ LA + T L + GD +GT+ G +++ S ++ PM AG
Sbjct: 304 NLVVVFSTFIVFLAFDLFRPAVTT---YLSKHAGDQQGTINGLNSTFTSFGNILGPMAAG 360
>UniRef50_Q56RY7 Cluster: TetA; n=4; Acinetobacter|Rep: TetA -
Acinetobacter sp. LUH5605
Length = 395
Score = 75.4 bits (177), Expect = 2e-12
Identities = 88/365 (24%), Positives = 157/365 (43%), Gaps = 32/365 (8%)
Query: 2 VDLLAVGLIIPLVPGHVRKMG---ANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXX 58
+D + +GLI+P++P +R + A ++ G L ++YA Q P++G+LSD GRR
Sbjct: 14 LDAVGIGLIMPILPELLRSLAGAEAGGVHYGALLAVYALMQFIFAPILGALSDRFGRRPV 73
Query: 59 XXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYG 118
+ Y ++ +A A V D ++ A+ +G
Sbjct: 74 LIISIAGATADYLLMAAAPSLLWLYIGRIFAGITGANMAVATAYVSDITPAHER-AKRFG 132
Query: 119 KMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXX 178
+ A+ G+G GP+IGG + E N + F AF+ GI I A L+
Sbjct: 133 LLGAVFGIGFIAGPVIGGVLGEWNLHAPFFAAAFMNGINLIMTAVLL---------KESK 183
Query: 179 XXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALY 238
+ + E +L K S+++ N + IFL LV V + + +Y
Sbjct: 184 HSNKMTEKVQEQSILK-----KLSYLITQP-NMAPLLGIFLIITLVS---QVPATLWVIY 234
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTG 298
+ Y S G ++ G+ SI+ F I K+ + ++ + + ++
Sbjct: 235 GQDRYGWSIFIAGVSLASYGICHSIAQAFA--IAPMVKR---FGEKNTLLCGIACDAIGL 289
Query: 299 LIVSINVYNYVIW-LIPL-AMGNAVSRLVTLEMVLKRSDGDHR-GTLIGASNSVRSLSGV 355
L++SI V +V + L+PL A+G + L+ ++ R D R G L G +S SL +
Sbjct: 290 LLLSIAVEEWVPFALLPLFALGGVA--VPALQAMMSRGISDERQGELQGLLSSFNSLGAI 347
Query: 356 VAPMV 360
+ P++
Sbjct: 348 IGPVL 352
>UniRef50_A6G4P6 Cluster: Multidrug resistance protein, putative;
n=1; Plesiocystis pacifica SIR-1|Rep: Multidrug
resistance protein, putative - Plesiocystis pacifica
SIR-1
Length = 445
Score = 74.1 bits (174), Expect = 6e-12
Identities = 46/161 (28%), Positives = 70/161 (43%), Gaps = 1/161 (0%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DL G+I+P++P + M A+ V LL + ++ Q P++G +SD GRR
Sbjct: 32 LDLAGFGIILPILPYYAESMDASATMVALLSTTFSAAQFVMSPVLGRISDRYGRRPIMLV 91
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
++A VLG K A A V D EQ+ A+ G M
Sbjct: 92 SIAGSALAALVLGFATALWLVFVARLVAGSSKANVSTAHAYVADLVPQEQR-AKYMGMMG 150
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNA 162
A G+G GP IGG + +P+ F A + + F+ A
Sbjct: 151 AAMGLGFVFGPGIGGMLALHSPHMPFFVSAGLSAVNFLMAA 191
>UniRef50_Q0LMR4 Cluster: Major facilitator superfamily MFS_1
precursor; n=1; Herpetosiphon aurantiacus ATCC
23779|Rep: Major facilitator superfamily MFS_1 precursor
- Herpetosiphon aurantiacus ATCC 23779
Length = 391
Score = 73.7 bits (173), Expect = 8e-12
Identities = 80/360 (22%), Positives = 141/360 (39%), Gaps = 24/360 (6%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
V ++ G++IP+ P + ++ GA+ + VG++ YA Q P++G LSD GRR
Sbjct: 15 VGTMSYGVVIPITPFYAQEFGASEVQVGMIVGSYALMQFIFAPILGQLSDRYGRRPLLIL 74
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
+ + G +A+A V D ++ +A G +
Sbjct: 75 SLIGTVCSLLLFGFANSLIWLFVGRMFDGATGGNISIAQAYVSDI-TTDKDRARGMGMVG 133
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXX 181
A G+G GP IG + +D +F+A GI + + L
Sbjct: 134 AALGLGFIAGPAIGALLSKDGNYQLPIFVA--AGIAVLSLILTIVVLPEPERHAPQQGRT 191
Query: 182 XXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKT 241
FN K +L ++ + L+ A + + +AL+
Sbjct: 192 --------------FNPMK----LLAAVRKPNVGRLLSITLLINLAFVAFETTFALFAAR 233
Query: 242 TYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIV 301
+ GY ++ G++ +I G I + + +L + LLL++SL GL
Sbjct: 234 RLEFGSHQTGYTLAGVGIVVAIVQG--GLIRRLAARFGEATL-IVSGSLLLALSLAGLGF 290
Query: 302 SINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVA 361
NV++ V I LA+G + +V + S RG +G S+ SL+ + AP+ A
Sbjct: 291 IQNVWHLVAICIVLAVGEGLLTPSLSSLVSRNSPASERGENMGLYQSMSSLARIFAPLYA 350
>UniRef50_A7H6K9 Cluster: Major facilitator superfamily MFS_1; n=2;
Anaeromyxobacter|Rep: Major facilitator superfamily
MFS_1 - Anaeromyxobacter sp. Fw109-5
Length = 386
Score = 72.5 bits (170), Expect = 2e-11
Identities = 41/135 (30%), Positives = 63/135 (46%), Gaps = 1/135 (0%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DLL G++IP++P + ++GA+ + GLL + Y+ Q P+ G LSD GRR
Sbjct: 16 IDLLGFGMVIPVMPLYAERLGASEAWTGLLSAGYSAMQFVFAPIWGRLSDRVGRRPVLLV 75
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
+VA+ + GL +A+A V D E + A G +
Sbjct: 76 SIAMTAVAFALYGLAGTFAMLLVSRLFAGAATANIAIARAFVADVTPPEGR-ARGMGIIG 134
Query: 122 AISGVGITLGPMIGG 136
A G+G LGP +GG
Sbjct: 135 AAFGLGFVLGPALGG 149
>UniRef50_Q6KYT7 Cluster: Tetracycline resistance protein; n=1;
Picrophilus torridus|Rep: Tetracycline resistance
protein - Picrophilus torridus
Length = 384
Score = 70.5 bits (165), Expect = 7e-11
Identities = 87/390 (22%), Positives = 155/390 (39%), Gaps = 41/390 (10%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
M+D + G+IIP+ P + R +GA +L +Y+ Q + P +G LSD GR+
Sbjct: 13 MIDFIGFGIIIPIAPFYTRDLGATPFEFSILLVVYSLAQFIASPYLGRLSDRIGRKNVLV 72
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
Y + GL+ + + V D +++ + I G +
Sbjct: 73 LGLSGEIAGYLIFGLSPVLSLLYIGRAITGATSGNLPVIYSFVSDKTSSDNRTRAI-GMI 131
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
A G+G +GP IGG + + G + I F + FI N LV +
Sbjct: 132 GAAIGIGFVIGPFIGGSL---SIFGYRVPILFAAVLSFI-NMVLVLRIKEERKKTNYKKG 187
Query: 181 XXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLY---KALVGFAMGVYYSNYAL 237
+ FV+L + Y+ LY VG +G+ AL
Sbjct: 188 SILKAFEIAPYIFISITFIALGFVMLQTT--LAYYGQALYSWGSLAVGIILGIVGMEQAL 245
Query: 238 Y-LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISL 296
+ L + L+ + +GSI + +G I SF + S R + S++L
Sbjct: 246 FQLLLVFRLTRR-----------IGSIRTVMLGII-SFTMAFLILSFRVNEYIAIFSLTL 293
Query: 297 TGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVV 356
L Y ++ P+ + +S + +E+ RG+ +G + S +SLS ++
Sbjct: 294 FSL-------GYSLFQTPVI--SIISDIAPVEI---------RGSTLGITQSAQSLSNII 335
Query: 357 APMVAGFTGQFLGVSYVIYASLAPTVLGLV 386
P++AG+T +F+ + + A +L L+
Sbjct: 336 GPLIAGYTFEFISIYSPYMLAAAFGILSLL 365
>UniRef50_P0A0J7 Cluster: Quinolone resistance protein norA; n=23;
Staphylococcus|Rep: Quinolone resistance protein norA -
Staphylococcus aureus
Length = 388
Score = 70.5 bits (165), Expect = 7e-11
Identities = 91/397 (22%), Positives = 162/397 (40%), Gaps = 34/397 (8%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
L +GL+IP++P +++ +G +GLL + +A Q+ P G+L+D G++
Sbjct: 17 LGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLI 76
Query: 65 XCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQML-AKALVPDYENNEQKQAEIYGKMAAI 123
SV+ + + M L+ D + QK A+ +G M+AI
Sbjct: 77 LFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQK-AKNFGYMSAI 135
Query: 124 SGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXX 183
G LGP IGG + E + F F + + FI + L+
Sbjct: 136 INSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLI------------------ 177
Query: 184 XDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTY 243
D + S F + + INW + + ++ F + + + Y+LY
Sbjct: 178 HD--PKKSTTSGFQKLEPQLLT--KINWKVFITPVILTLVLSFGLSAFETLYSLYTADKV 233
Query: 244 DLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSI 303
+ SPK + I+ G+ G++ + I + + F K + L + LL S+ + L+V
Sbjct: 234 NYSPKDISIAITGGGIFGAL--FQIYFFDKFMKYFSE--LTFIAWSLLYSVVVLILLVFA 289
Query: 304 NVYNYVIWLIPLAMGNAVSRL-VTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG 362
N Y + I LI + + + G+ +G G +++ S+ + P++AG
Sbjct: 290 NGY-WSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAG 348
Query: 363 --FTGQFLGVSYV-IYASLAPTVLGLVMSYHYRTKRK 396
F Y+ I SLA V+ L+ H R K K
Sbjct: 349 ALFDVHIEAPIYMAIGVSLAGVVIVLIEKQH-RAKLK 384
>UniRef50_UPI000065CAB2 Cluster: Organic cation transporter-like
protein 2 (Imprinted multi-membrane spanning
polyspecific transporter-related protein 1) (Efflux
transporter-like protein) (Tumor-suppressing
subchromosomal transferable fragment candidate gene 5
protein) (Tumor-suppressing; n=1; Takifugu rubripes|Rep:
Organic cation transporter-like protein 2 (Imprinted
multi-membrane spanning polyspecific transporter-related
protein 1) (Efflux transporter-like protein)
(Tumor-suppressing subchromosomal transferable fragment
candidate gene 5 protein) (Tumor-suppressing - Takifugu
rubripes
Length = 388
Score = 69.7 bits (163), Expect = 1e-10
Identities = 79/362 (21%), Positives = 142/362 (39%), Gaps = 15/362 (4%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+D+ + L + P +K+G + ++ G L ++ QL GPL G DL G R
Sbjct: 14 LDITWMFLQFSITPYLAKKLGFDTLWFGYLQTMVGFCQLFGGPLFGRFGDLFGARTALSV 73
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
SV + +L ++ +V D E K+A+ K+
Sbjct: 74 ACSS-SVVFFLLLAAANHPAMLFIHKLPTLLMHIIPTSQMVVTDLSEPE-KRADALSKLG 131
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXX 181
GVG+ G +GGH+ N A + F+ LV L
Sbjct: 132 LCFGVGMIAGSTLGGHL---NTRYGEKITACVGAAGSFFSLLLV--LKFIPKNTKVHAST 186
Query: 182 XXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKT 241
+ S+ S+F S Q + + + F+ K V G++ +++
Sbjct: 187 ATANAGSDKKT-SIF-SVDQ---ITRLMKFPGVARTFIVKIAVSLPSGIFQVMFSIIALE 241
Query: 242 TYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIV 301
+ L P+ GY+++F G++ + G I + + SL L V + + L G
Sbjct: 242 FFKLQPEENGYLMAFFGIVQMVIQG--GVIGRMTARFSESSLLLLSVGVSALVGL-GQAN 298
Query: 302 SINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVA 361
V++ + +IP+ ++ ++T M+ K GT++G +SV+SL V P +
Sbjct: 299 MQTVFHLCLTIIPMMFSLSMFNVITDSMLTKSVPSSDTGTMLGLCSSVQSLLRTVGPTIG 358
Query: 362 GF 363
GF
Sbjct: 359 GF 360
>UniRef50_Q0C4X1 Cluster: Tetracycline-efflux transporter; n=1;
Hyphomonas neptunium ATCC 15444|Rep: Tetracycline-efflux
transporter - Hyphomonas neptunium (strain ATCC 15444)
Length = 417
Score = 69.7 bits (163), Expect = 1e-10
Identities = 87/369 (23%), Positives = 153/369 (41%), Gaps = 37/369 (10%)
Query: 2 VDLLAVGLIIPLVP------GHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
+D LA GLIIP++P +V GA +++G L + YA GPLIG+LSD GR
Sbjct: 24 IDHLAFGLIIPVLPTLIQDLANVPASGAT-LWIGGLAATYAVMTFLFGPLIGALSDKFGR 82
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R + + ++ L T A A + D E++
Sbjct: 83 RPVLLVSMAMLGLDFLLMALAPNIWILFLGRALAGISGATYSTANAYIADTTTPEER-GR 141
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXX 175
+G + A G+G GP+IGG + E P F F A VG+ F+ N F+
Sbjct: 142 AFGFIGASFGLGFIFGPVIGGLLGELGPRIPF-FAA--VGLAFL-NFLYGVFVLPESLPK 197
Query: 176 XXXXXXXXXDVLSENLVLSLFNSF--KQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYS 233
NL L N + F L ++W + + A V+ +
Sbjct: 198 AR----------RRNLNLKRANPLGAARHFSKLPKVSW-----FLIASGIFFLAHTVFPA 242
Query: 234 NYALYLKTTYDLSPKYVGYVISFQGV-MGSISSYFIGYINSFYKKDVDYSLRSLHVFLLL 292
++++ + YD SP +G + GV ++ + +G+I K + + + +
Sbjct: 243 TWSVHGEIRYDWSPMQIGLSLGLVGVGAATVQAGLMGFI----LKRLGSVRTIMFGYCVT 298
Query: 293 SISLTGL-IVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRS 351
I++TG ++ Y+I IP + V+ ++ + D +G L GA++S+ +
Sbjct: 299 IIAMTGFAFAGQPLFAYLI--IPFSALGGVTMPAANALMSSLTPPDAQGELQGAASSLNA 356
Query: 352 LSGVVAPMV 360
L ++ P++
Sbjct: 357 LGMIIGPLI 365
>UniRef50_Q5N0B7 Cluster: Multidrug-efflux transporter quinolene
resistance protein NorA; n=2; Synechococcus
elongatus|Rep: Multidrug-efflux transporter quinolene
resistance protein NorA - Synechococcus sp. (strain ATCC
27144 / PCC 6301 / SAUG 1402/1)(Anacystis nidulans)
Length = 403
Score = 68.5 bits (160), Expect = 3e-10
Identities = 49/169 (28%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+D L V L++P++P +R G+N +G S+Y Q S P++GSLSD GRR
Sbjct: 24 MDALGVTLLLPILPELLRPFGSNAFLLGAFASVYTLAQFISTPVLGSLSDRFGRRPPLIL 83
Query: 62 XXXXCSVAYTVL---GLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYG 118
+AY +L L +A+A + D E++ K++ +G
Sbjct: 84 TLVFTGLAYVLLAVGSLVENLPLLFAARILAGLAGGVFAIAQAYIADRESDPLKRSTQFG 143
Query: 119 KMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCF 167
+ A G+G GP +GG + N F A + I NAAL F
Sbjct: 144 WIGAAFGLGFLFGPALGGLLSGINLRLPIWFAAILAFI----NAALTVF 188
>UniRef50_A3VAE1 Cluster: Tetracycline resistance protein; n=3;
Rhodobacterales|Rep: Tetracycline resistance protein -
Rhodobacterales bacterium HTCC2654
Length = 406
Score = 68.5 bits (160), Expect = 3e-10
Identities = 77/366 (21%), Positives = 152/366 (41%), Gaps = 29/366 (7%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANH-----IYVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D + VGLI PL+P + ++GA + G+L + YA Q P +G LSD GR
Sbjct: 15 LIDAIGVGLIFPLMPDLMDRVGAGGASNGAVLGGILMAAYAATQFLCAPAVGGLSDAVGR 74
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
+ +V Y ++ L T + A A + D E K+A
Sbjct: 75 KPVLLVALATLAVDYVIMALATSFWLLLAGRLLAGVAGATYITATAYLADISTPE-KRAA 133
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXX 175
+G + A G+G LGP +GG + + F A + +AA V F
Sbjct: 134 NFGLIGATFGIGFVLGPALGGLLAGIDVTAPFWVAAAL-------SAANVAFGLAVLPES 186
Query: 176 XXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNY 235
N ++ ++F+ + L +F+++ FA VY + +
Sbjct: 187 LAPAKRRAFRASDLNPFGAIRDAFRMPALAL------PLACMFVFE----FANMVYPTLW 236
Query: 236 ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSIS 295
A + + + S +G ++ GV +++ + + + K+ ++ + + F LL+ +
Sbjct: 237 AFWGREAFGWSATMIGGTLAAYGVGVALTQGLV--LPALLKRMSEHGVLT---FALLTGT 291
Query: 296 LTGLIVSINVYNYVIWLI-PLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSG 354
+ +++ +I P+A + ++ ++ +D D +G L G S+ SL+
Sbjct: 292 VAAFAFGFTTAPWLVAVILPIACLSDMAPPTLTAIMANATDEDRQGVLQGVIASLGSLAA 351
Query: 355 VVAPMV 360
+ AP++
Sbjct: 352 IFAPLL 357
>UniRef50_P02981 Cluster: Tetracycline resistance protein, class C
(TetA(C)); n=117; root|Rep: Tetracycline resistance
protein, class C (TetA(C)) - Escherichia coli
Length = 396
Score = 68.5 bits (160), Expect = 3e-10
Identities = 78/386 (20%), Positives = 167/386 (43%), Gaps = 33/386 (8%)
Query: 2 VDLLAVGLIIPLVPGHVRKM-GANHI--YVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXX 58
+D + +GL++P++PG +R + ++ I + G+L ++YA Q P++G+LSD GRR
Sbjct: 16 LDAVGIGLVMPVLPGLLRDIVHSDSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPV 75
Query: 59 XXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYG 118
++ Y ++ T T +A A + D + E + A +G
Sbjct: 76 LLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADITDGEDR-ARHFG 134
Query: 119 KMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXX 178
M+A GVG+ GP+ GG + + + F+ A + G+ N L CFL
Sbjct: 135 LMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGL----NLLLGCFLMQESHKGE-- 188
Query: 179 XXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALY 238
+ L FN + +F LVG V + + ++
Sbjct: 189 ---------RRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVG---QVPAALWVIF 236
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTG 298
+ + S +G ++ G++ +++ F+ K+ + + + + + +L
Sbjct: 237 GEDRFRWSATMIGLSLAVFGILHALAQAFV--TGPATKR---FGEKQAIIAGMAADALGY 291
Query: 299 LIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRS-DGDHRGTLIGASNSVRSLSGVVA 357
++++ ++ + I + + + + L+ +L R D DH+G L G+ ++ SL+ +
Sbjct: 292 VLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITG 351
Query: 358 PMV-----AGFTGQFLGVSYVIYASL 378
P++ A + G+++++ A+L
Sbjct: 352 PLIVTAIYAASASTWNGLAWIVGAAL 377
>UniRef50_Q28RT4 Cluster: Major facilitator superfamily MFS_1; n=16;
Bacteria|Rep: Major facilitator superfamily MFS_1 -
Jannaschia sp. (strain CCS1)
Length = 406
Score = 68.1 bits (159), Expect = 4e-10
Identities = 48/164 (29%), Positives = 74/164 (45%), Gaps = 6/164 (3%)
Query: 2 VDLLAVGLIIPLVPG---HVRKMG-ANH-IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
+D + +GLI+P++P VR G AN ++ GLL + YA Q P +G+LSD GRR
Sbjct: 14 IDAMGIGLILPVMPDLITEVRGAGLANAALWGGLLSTTYAVMQFLCSPTLGNLSDRFGRR 73
Query: 57 XXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
+ Y V+ L T A A + D E K+A+
Sbjct: 74 PILLISLAVLAADYVVMSLAHTIWILIAGRIVAGIAAGTHATALAYMADISPPE-KRAQN 132
Query: 117 YGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIF 160
+G ++A G+G LGP++ + E +P F+ A + F F
Sbjct: 133 FGLISAGFGIGFVLGPLVAAFLGEFDPRAPFVAAACLAAANFAF 176
>UniRef50_Q32LS0 Cluster: Zgc:123168; n=9; Euteleostomi|Rep:
Zgc:123168 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 400
Score = 67.7 bits (158), Expect = 5e-10
Identities = 83/379 (21%), Positives = 154/379 (40%), Gaps = 21/379 (5%)
Query: 13 LVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTV 72
+ P R++G + I+ G L + QL GP+ G +D+ G R SV Y
Sbjct: 30 ITPYLARRLGFDTIWFGYLQTTVGVIQLLGGPIYGRFADIFGARAALSVSCGA-SVFY-F 87
Query: 73 LGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGP 132
L LT + +V + ++K+AE GK+ G+G+ G
Sbjct: 88 LPLTVADSPFMLFVHKLPAVFMHALPGAQMVVADLSEKEKRAEALGKLGLCFGIGMIAGS 147
Query: 133 MIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLV 192
+GG + G +F F+ +L+ L + S
Sbjct: 148 SLGGTL--STRFGERFAASFGAVGSFV---SLMLVLNFIPKQTKTQTTPESDEKGSSK-- 200
Query: 193 LSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGY 252
S+FN + + + + F K + G G++ +++ + L + GY
Sbjct: 201 -SVFNMGE----ITRLMKFPGVAKTFTVKIISGLPTGIFQVMFSIIAMNFFQLKAEQNGY 255
Query: 253 VISFQGVMGS-ISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIW 311
++++ G++ I IG + S + ++ SL L V + + L +++ NV+ +
Sbjct: 256 LMAYFGIVQMVIQGAVIGRLTSSFSEN---SLLLLSVGVSSLVGLAQALMT-NVFQFCFI 311
Query: 312 LIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGV- 370
+IP+ +V ++T M+ K GT++G SV+SL V P + GF + GV
Sbjct: 312 VIPMMFSLSVFNVITDSMLTKSVSPADTGTMLGLCASVQSLLRTVGPTIGGFLYETYGVP 371
Query: 371 SY-VIYASLAPTVLGLVMS 388
S+ I + V GL+++
Sbjct: 372 SFGYIQCVINAAVFGLLLT 390
>UniRef50_Q3BM88 Cluster: Drug:H+ antiporter-1 family protein; n=5;
Xanthomonas|Rep: Drug:H+ antiporter-1 family protein -
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Length = 449
Score = 67.3 bits (157), Expect = 7e-10
Identities = 88/396 (22%), Positives = 156/396 (39%), Gaps = 33/396 (8%)
Query: 1 MVDLLAVGLIIPLVPGHVRKM-GANHI----YVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D+L+ G+IIP++P VR G +++ ++G G ++A Q PL G+LSD GR
Sbjct: 54 LIDVLSFGVIIPVLPDLVRHFTGGDYVVAAGWIGWFGFLFAAIQFVCSPLQGALSDRFGR 113
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R + + ++ + + A A + D + K+A
Sbjct: 114 RPVILLSCLGLGLDFILMAIAHSLPMLLLARVISGVCSASFSTANAYIADVTPPD-KRAG 172
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXX 175
+G + A G+G GP+IGG + F F A + + N F+
Sbjct: 173 AFGMLGAAFGIGFVAGPLIGGWLGSIGLRWPFWFAAGLA----LLNVLYGWFVLPESLPA 228
Query: 176 XXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNY 235
+ L L + Q F L S+ +F L A VY S +
Sbjct: 229 ERRTARLDWSHANPLGALKLLRRYPQVF-GLASV-------VF----LANLAHYVYPSIF 276
Query: 236 ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLL-LSI 294
L+ Y P+ V +V++ GV I +N+ + L LL L
Sbjct: 277 VLFAGYQYHWGPREVSWVLAGVGVCSII-------VNALLVGRLVRRLGERRALLLGLGC 329
Query: 295 SLTGLIVSINVYNYVIWLI--PLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSL 352
+ G I+ + +LI P++ A++ ++ + D +G + GA + SL
Sbjct: 330 GVIGFIIYGLADSGTAFLIGVPISALWAIAAPSAQALITREVGADAQGRVQGALTGLVSL 389
Query: 353 SGVVAPMV-AGFTGQFLGVSYVIYASLAPTVLGLVM 387
+G+ P++ A F+G ++ AP +L V+
Sbjct: 390 AGIAGPLLFANVFAWFIGSGAPLHLPGAPWLLAAVL 425
>UniRef50_A3U1K1 Cluster: Putative transport transmembrane protein;
n=1; Oceanicola batsensis HTCC2597|Rep: Putative
transport transmembrane protein - Oceanicola batsensis
HTCC2597
Length = 428
Score = 67.3 bits (157), Expect = 7e-10
Identities = 48/170 (28%), Positives = 74/170 (43%), Gaps = 6/170 (3%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANH-----IYVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D++ VGLI P++P +R +G + G + + YA Q GPLIGSLSD GR
Sbjct: 22 LIDMIGVGLIWPVIPALLRDVGHAELADASVIGGWMFAAYALAQFLFGPLIGSLSDAYGR 81
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R +V Y L + ++A A + D E + A
Sbjct: 82 RSLLLLAIGGLAVDYVFSALAPTFWLLILGRIIAGICGASHIIATAYLTDITPPEGR-AR 140
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALV 165
+G + A G+G +GP +GG + E P F A + F F A++
Sbjct: 141 AFGMIGAAFGLGFVIGPALGGLLGEFGPRVPFWAAAALAAANFAFGYAVL 190
>UniRef50_A5GP24 Cluster: Permease of the major facilitator
superfamily; n=1; Synechococcus sp. WH 7803|Rep:
Permease of the major facilitator superfamily -
Synechococcus sp. (strain WH7803)
Length = 397
Score = 66.5 bits (155), Expect = 1e-09
Identities = 84/392 (21%), Positives = 155/392 (39%), Gaps = 30/392 (7%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGA--NHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXX 59
VD + GL++P+VP V ++ N I V + + Y+G Q PLIG LSD GRR
Sbjct: 15 VDAASFGLLLPVVPFFVNELTGSFNAIAVTSVTATYSGLQFLGAPLIGRLSDRWGRRSVL 74
Query: 60 XXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGK 119
++A L+ +++ALV D + ++ +G
Sbjct: 75 TVTVAISAIALIGQALSTSLLILLLFSALNGASSGVFAISQALVADTVEDRNQRTVGFGA 134
Query: 120 MAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICF-IFNAALVCFLXXXXXXXXXX 178
+ A G+G +GP IGG + +P F+V F + N L+
Sbjct: 135 IGAALGLGFIIGPGIGGALGAIDPR-----FPFVVASAFCLLNVVLIRLYLPKTTRSNQP 189
Query: 179 XXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALY 238
++N +L+ N + + +Y FL+ +GF+ + + L
Sbjct: 190 EASTEK---TKNPLLTQGNHRLKKLISIY----------FLF--YLGFS--AFSGIFVLA 232
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTG 298
K ++ P+ V+ + GV+ + G + K + S+ L+++++ G
Sbjct: 233 AKERFNWGPQPTSLVLVYVGVVAVVVQ---GALLPRLLKAIRPDKLSIIGLSLVAVAMLG 289
Query: 299 LIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAP 358
+ V + A G +S + + +G L G + SV SL+ ++ P
Sbjct: 290 VSVISEGRELYVTQFLFAGGVGLSTPGLRSAMSLCVNESQQGVLGGMTQSVVSLTSLIGP 349
Query: 359 MVAG--FTGQFLGVSYVIYASLAPTVLGLVMS 388
++AG + G ++ A L +GL+ S
Sbjct: 350 LLAGQMYESAGYGATFQTQAVLVLIAVGLLAS 381
>UniRef50_Q0W0M4 Cluster: Putative permease; n=1; uncultured
methanogenic archaeon RC-I|Rep: Putative permease -
Uncultured methanogenic archaeon RC-I
Length = 434
Score = 66.1 bits (154), Expect = 2e-09
Identities = 74/367 (20%), Positives = 150/367 (40%), Gaps = 17/367 (4%)
Query: 8 GLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCS 67
G+IIP++P + R + A +GLL + ++ Q GP+ G +SD GR+ +
Sbjct: 23 GIIIPIIPYYTRSVNATAFDLGLLLATFSFLQFFCGPIWGKISDHIGRKPVIIFSLLGFT 82
Query: 68 VAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLA-KALVPDYENNEQKQAEIYGKMAAISGV 126
+A+ ++GL+ A A V D ++A++ G M A+SG+
Sbjct: 83 LAFAMVGLSSQLWMIFIAVSIGGFFSAGIFPAVLAFVADI-TQPSERAKLMGLMGAVSGL 141
Query: 127 GITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDV 186
G+ LGP + + F A I I I +V +
Sbjct: 142 GLILGPFASSLLAVYGLSAPFFAAALISFITMI--GCMVLIPESITYTQIVKIRDAVKPL 199
Query: 187 LSENLVLS----LFNSFKQSF------VVLYSINWSKYWDIFLYKALVGFAMGVYYSNYA 236
N+++ +F + K +++ S S + F Y + + S
Sbjct: 200 SMLNMIIETFRHMFTALKTGLGVFLMAMLVISFAISGFEGTFTYFLMDKIGLSSVTSFVK 259
Query: 237 LYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISL 296
++ + P+ +G V + +MG++S G I + + + L+ S+ +
Sbjct: 260 VFDSGIHLTGPEAMGIVFA---MMGAVSVICQGLIVAKAIEMFGEEKVIIFGLLIASVGM 316
Query: 297 TGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVV 356
L+ S ++ +I++ +++G+ + +V +R+D ++G +G +S S V+
Sbjct: 317 ILLLTSTDLGTALIYICIISVGSGLVFPCLNTVVSRRTDERNQGVAMGILSSYGSFGRVL 376
Query: 357 APMVAGF 363
P+V G+
Sbjct: 377 GPIVGGY 383
>UniRef50_Q2MDB3 Cluster: Tetracycline efllux protein; n=6;
Proteobacteria|Rep: Tetracycline efllux protein -
Acinetobacter baumannii
Length = 363
Score = 64.9 bits (151), Expect = 4e-09
Identities = 37/141 (26%), Positives = 61/141 (43%), Gaps = 1/141 (0%)
Query: 20 KMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXX 79
K + +IY+G+L S+YA Q PL+G+LSD GRR ++ Y L +
Sbjct: 4 KPNSRYIYMGILASLYAAMQFIFSPLLGALSDRWGRRPVLLISLAGSAINYLFLTFSHSL 63
Query: 80 XXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIM 139
+A + D + E +A+ +G + A G G +GP++GG +
Sbjct: 64 ILLLVGRIIAGITSANMAVASTYIVDV-SQENNRAKYFGLINATFGAGFIIGPVLGGFLS 122
Query: 140 EDNPNGAFMFIAFIVGICFIF 160
E F A + G+ +F
Sbjct: 123 EYGLRLPFFAAAILTGLNLLF 143
>UniRef50_A3I4T4 Cluster: Blt; n=1; Bacillus sp. B14905|Rep: Blt -
Bacillus sp. B14905
Length = 384
Score = 64.5 bits (150), Expect = 5e-09
Identities = 81/367 (22%), Positives = 146/367 (39%), Gaps = 42/367 (11%)
Query: 6 AVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXX 65
++G+IIP++P ++R GA +G+L + +A Q P+ G+LSDL GR+
Sbjct: 10 SIGIIIPVMPEYLRIFGAAGQVLGMLIATFALAQFVFSPIAGNLSDLYGRKNLIIFGLIL 69
Query: 66 CSVAYTVLGL-TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAIS 124
+A GL T A V D E++ + + A
Sbjct: 70 TGLAQIGFGLSTDVWMLFLARFLGGLGSAFVAPPIMAFVADVTTYEER-GKGMSMLGAAM 128
Query: 125 GVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXX 184
G +GP IGG + + + + F F+ G I + L FL
Sbjct: 129 SFGFMIGPGIGGFLAKVSLHFPF----FMAGAAAILASILSYFLLPSTKPNTAQNRQK-- 182
Query: 185 DVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYD 244
+NLV + S + V+ + + F + + + +L++ ++
Sbjct: 183 ---QDNLVKQMARSVHMPYFVM-----------LIIMMVFSFGIANFQTTLSLFVTEKFN 228
Query: 245 LSPKYVGYVISFQGVMGSISSYFIGYINSFYKKD-------VDYSLRSLHVFLLLSISLT 297
SP + ++ G G I FI I +K+ V+ + S+ +FL+L +S
Sbjct: 229 YSPGDIATILVVGGAFGVIVQMFI--ITPLFKRFGEMKVVLVNLFIASIAIFLILFVSGF 286
Query: 298 GLIVSI-NVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVV 356
LI+ + +++ LI A+ +S+L E +G G +N+ SL ++
Sbjct: 287 ALILVVATIFSTATTLIRPAVNTLISKLAETE----------QGFAAGLNNAYMSLGNMI 336
Query: 357 APMVAGF 363
P +AGF
Sbjct: 337 GPALAGF 343
>UniRef50_Q4J724 Cluster: Drug transporter; n=1; Sulfolobus
acidocaldarius|Rep: Drug transporter - Sulfolobus
acidocaldarius
Length = 396
Score = 64.1 bits (149), Expect = 6e-09
Identities = 86/386 (22%), Positives = 153/386 (39%), Gaps = 36/386 (9%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+D + G+IIP++P + ++GA I LL Y+ QL P I LSD++GR+
Sbjct: 24 LDSVGFGIIIPILPYYSLQLGATPIEYSLLTVTYSIAQLVFSPYISRLSDIRGRKNILTL 83
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
V Y ++GL+ T L L E + I G ++
Sbjct: 84 GIGSEVVGYLIIGLSPYFYLLLLARFITGAL--TSNLPVILSYATELGKDNSRNI-GIIS 140
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXX 181
GVG GP+IGG + F+ +A G+ F+ N LV L
Sbjct: 141 GTFGVGFVAGPVIGGVLSPLGYRNTFLIVA---GLAFL-NLILVYLL------------- 183
Query: 182 XXXDVLSENLVLSLFN-SFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
V ++N +++ S K+ F + S F ++ + V A Y +
Sbjct: 184 ----VSNDNKKIAMRQASLKEIFRMSSS--------FFTLTLIIALSFAVLQGTLAFYGR 231
Query: 241 TTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLI 300
Y+ P +G V+ G++ +++ + + Y + + L + + I L+
Sbjct: 232 YFYNWGPSQIGLVLGLVGIVQAVAQFLLVYRIIGKAGERIATTIGLSITFIAYILLS--F 289
Query: 301 VSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMV 360
S + YV L+ LAMGN +++ L ++ K R G + S +L ++ +
Sbjct: 290 PSNQILAYVS-LVLLAMGNGIAQNSILTLLSKTLPPGSRSGGFGFAQSSTALGSLIGFPL 348
Query: 361 AGFTGQFLGVSYVIYASLAPTVLGLV 386
Q L + + A ++L +V
Sbjct: 349 GNTMFQVLSPNSEYFLCSALSILSIV 374
>UniRef50_Q65F99 Cluster: Blt; n=2; Bacillus|Rep: Blt - Bacillus
licheniformis (strain DSM 13 / ATCC 14580)
Length = 398
Score = 63.7 bits (148), Expect = 8e-09
Identities = 71/362 (19%), Positives = 152/362 (41%), Gaps = 25/362 (6%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
+L +GLIIPL+P + + GA+ +GLL + QL P+ G ++D GRR
Sbjct: 18 MLGIGLIIPLMPTFIEEFGASGSTLGLLIAASGITQLLFSPVAGEMTDKYGRRKMIILGI 77
Query: 64 XXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAK-ALVPDYENNEQKQAEIYGKMAA 122
+V+ + L + A A + D +E+ +++ G ++A
Sbjct: 78 GAFAVSQLLFALASQMWLLFVSRLLGGAGAAFLVPAMFAYIADI-TSEKDRSKGMGLISA 136
Query: 123 ISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXX 182
+G +GP GG++ F A + G+ + + ++
Sbjct: 137 AMSLGFVIGPGAGGYLAAFGLTFPFYVSAGLAGLATVLSLLVLPETLSQEKMLEKRRSVQ 196
Query: 183 XXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTT 242
+ L++ + +L + + F++++ +N+ I ++A+ ++LY+
Sbjct: 197 KREPLAKQMARALRSPYAFLFILVFILNFG----IMNFEAV-----------FSLYVDHK 241
Query: 243 YDLSPKYVGYVISFQGVMG-SISSYFIGYI-NSFYKKDVDYSLRSLHVFLLLSISLTGLI 300
+ +P + +VI+ ++G + + +G + N F +K + L S+ G
Sbjct: 242 HGFTPGDIAFVITAASLIGVFVQAVALGMLTNRFGEKKLMNMTLIGSAGALAVCSIAGSY 301
Query: 301 VSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMV 360
+ V +++ + A++ L++ + GD +G G +N+ SL+ +V P V
Sbjct: 302 WLVFGATIVFFMLTSILRPAINTLIS------KMAGDEQGFAAGMNNAFMSLANIVGPTV 355
Query: 361 AG 362
AG
Sbjct: 356 AG 357
>UniRef50_Q04U94 Cluster: Permease; n=5; Bacteria|Rep: Permease -
Leptospira borgpetersenii serovar Hardjo-bovis (strain
JB197)
Length = 408
Score = 63.7 bits (148), Expect = 8e-09
Identities = 82/395 (20%), Positives = 159/395 (40%), Gaps = 30/395 (7%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHI-----YVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D++ G+IIP++P ++++ + Y GLL Y+ Q S P +G LSD GR
Sbjct: 21 LIDVIGFGVIIPVLPKLIQELTHGSLSDVAWYGGLLMFAYSFVQFISAPFVGGLSDRYGR 80
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R ++ Y L + A + D E K+A+
Sbjct: 81 RPILLASLFGFTLDYLFLAFAPSIFWLFVGRVVSGIMGASFTTGYAYIADISPPE-KRAQ 139
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXX 175
+G + A G+G +GP+IGG + + F+ A + + ++F ++
Sbjct: 140 NFGILGAAFGLGFIIGPVIGGSLGQFGSRAPFLAAAALTLVNWLFGFFVL-------PES 192
Query: 176 XXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNY 235
+ N + SL N + +V I + FL G + NY
Sbjct: 193 LTDENRRKFEWKKANPIDSLINLKRYPMIVGLIIAF------FLINTAAHAVQGTW--NY 244
Query: 236 ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLS-I 294
Y + + +GY + GV+G + + G + + + RS+++ L LS +
Sbjct: 245 --YTMEKFQWNEAMIGYSL---GVVGLVYAVTQGGLIRIILPVLGQN-RSIYLGLALSAL 298
Query: 295 SLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSG 354
++ + ++LIP +G ++ ++ + +G L GA S+ S++
Sbjct: 299 GYALFAIATQSWMMFVFLIPYCLG-GIAMPPLQGIMSSQVPPREQGELQGALTSLMSVTA 357
Query: 355 VVAP-MVAGFTGQFLGVSYVIYASLAPTVLGLVMS 388
+V P ++ G F IY+ AP +G +++
Sbjct: 358 IVEPILMTGLFSYFTARETPIYSPEAPLWMGTILT 392
>UniRef50_A0LD21 Cluster: Major facilitator superfamily MFS_1; n=1;
Magnetococcus sp. MC-1|Rep: Major facilitator
superfamily MFS_1 - Magnetococcus sp. (strain MC-1)
Length = 412
Score = 63.7 bits (148), Expect = 8e-09
Identities = 90/388 (23%), Positives = 158/388 (40%), Gaps = 22/388 (5%)
Query: 2 VDLLAVGLIIPLVPGHVRK--MGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXX 59
+DLL GL++PL+P + A+ + +G+L IY+ Q PL G LSD GRR
Sbjct: 16 LDLLGFGLVLPLLPNYASDPMFHASTMEIGVLMGIYSLMQFLFAPLWGRLSDHIGRRPVL 75
Query: 60 XXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGK 119
+++Y + GL A+A + D E K+A+ G
Sbjct: 76 IIGLFGSALSYLIYGLAESLMVLILSRALAGFMGANIAAAQAAMADLTPPE-KRAQAMGI 134
Query: 120 MAAISGVGITLGPMIGGHIMED-NPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXX 178
+ A +G LGP +GG++ + A + A I G+ NA FL
Sbjct: 135 IGAAFSLGFVLGPAMGGYLASTYGISAAPLAAALITGL----NAVAALFL----LSETRD 186
Query: 179 XXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALY 238
LS+ + +KQ+ ++ + +F+ F M + +
Sbjct: 187 LSTEQQQPLSKRAHPLSLHPWKQARNYPGALMVCLFMGLFI-TLFAAFEMALPLWTQIIM 245
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTG 298
+ + G++ +F GV+ +I G + K + +R+ + L+ I+L G
Sbjct: 246 GWDSGSQTMAENGHLFAFVGVVMAIVQG--GIVRRLVPKIGE--VRTAYSG-LICIAL-G 299
Query: 299 LIVSINVYNYVIWLIPLAMGNAVSRLV---TLEMVLKRSDGDHRGTLIGASNSVRSLSGV 355
L++ NY LI L + + LV +V +D D +G ++G S+ +L V
Sbjct: 300 LMLLGQASNYTTLLIALGLAATGAGLVHPAFSSLVSLNTDKDKQGLMMGLFQSMGALGRV 359
Query: 356 VAPMVAGFTGQFLGVSYVIYASLAPTVL 383
+ P+ AG L + +++ TVL
Sbjct: 360 LGPLWAGIAFVSLKGNLFFVSAMGMTVL 387
>UniRef50_UPI0000E47E1B Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 387
Score = 62.9 bits (146), Expect = 1e-08
Identities = 82/375 (21%), Positives = 152/375 (40%), Gaps = 37/375 (9%)
Query: 29 GLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXX--- 85
G L + ++G L GP+ G D+ G R + Y +LGL
Sbjct: 7 GYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISRIP 66
Query: 86 XXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNG 145
+ TQM+ L ++E + E G+++ +GI +GP+IGG I
Sbjct: 67 SLFLHAFQGTQMVISDL-----SDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQ 121
Query: 146 AFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVV 205
+ +A +G C + A ++ F+ D S+ S+F S K +
Sbjct: 122 SAAAVA-CIGSC-VSLALVILFI---PSNTKPVQSTSAKDKSSD----SVF-SIKTFTHL 171
Query: 206 LYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISS 265
+ S + ++ L G ++ S +AL + ++L+ GY +SFQG+ +
Sbjct: 172 MRSSPGAAFF--LSVNLLAGLPSAIFSSMFALVVIDKFELTADQNGYFLSFQGLASIVMQ 229
Query: 266 YFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLV 325
+ I K+ + L +LL+ S + + +V+ L+P+ GN ++ V
Sbjct: 230 GVV--IGRLTKRYSEMKLLRASA-ILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTV 286
Query: 326 TLEMVLKR--SDGDHRGTLIGASNSVRSLS-------GVVAPM-VAGFTGQFLGVSYV-- 373
++ K + R + G S R ++ PM V+ TG LG+++
Sbjct: 287 ITSVLTKAVPASESGRSSRSGTSQFSRPMAHETQSPPDPTRPMSVSRLTGTILGLTHAGT 346
Query: 374 -IYASLAPTVLGLVM 387
+ +LAP ++G V+
Sbjct: 347 SLLGTLAP-IIGAVL 360
>UniRef50_Q7UXZ3 Cluster: Tetracycline-efflux transporter; n=1;
Pirellula sp.|Rep: Tetracycline-efflux transporter -
Rhodopirellula baltica
Length = 500
Score = 62.9 bits (146), Expect = 1e-08
Identities = 38/141 (26%), Positives = 65/141 (46%), Gaps = 6/141 (4%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHI-----YVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D+LA+G+IIP++P +++ YVG++G+ Y+ Q P++G+LSD GR
Sbjct: 72 LIDILAIGIIIPVLPELIKEFVGGDTSRASWYVGVIGATYSLMQFFFAPVLGALSDRFGR 131
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R V + V GL + A A + D E + A
Sbjct: 132 RPVILASLFGLGVDFIVTGLAPTVGWLFVGRIVAGVMGASFSTANAYIADVSTQETR-AR 190
Query: 116 IYGKMAAISGVGITLGPMIGG 136
+G + + G+G +GP +GG
Sbjct: 191 NFGLVGMMFGLGFIIGPALGG 211
>UniRef50_A5G2L8 Cluster: Major facilitator superfamily MFS_1; n=1;
Acidiphilium cryptum JF-5|Rep: Major facilitator
superfamily MFS_1 - Acidiphilium cryptum (strain JF-5)
Length = 405
Score = 62.9 bits (146), Expect = 1e-08
Identities = 43/165 (26%), Positives = 74/165 (44%), Gaps = 6/165 (3%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGA---NH--IYVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D + GLI P++P V K+ A +H ++VG+L +A Q + P++G LSD GR
Sbjct: 9 VIDSIGFGLIAPILPDLVEKLSATPASHAALWVGVLSMTFAATQFFAAPVLGQLSDRFGR 68
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R + Y +L A A + D E ++A+
Sbjct: 69 RRLILVSLAGSAANYLLLAFAPNLLWLFVGRLIAGATAGNVSAASAYIADITPPE-RRAQ 127
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIF 160
+G + A G+G T GP+IGG + + F+ A +V + ++
Sbjct: 128 RFGLIGAAFGLGFTTGPVIGGFLGAIDLRLPFLVSAGLVAVNVVY 172
>UniRef50_Q07282 Cluster: Tetracycline resistance protein, class E
(TetA(E)); n=85; root|Rep: Tetracycline resistance
protein, class E (TetA(E)) - Escherichia coli
Length = 405
Score = 62.9 bits (146), Expect = 1e-08
Identities = 42/161 (26%), Positives = 75/161 (46%), Gaps = 4/161 (2%)
Query: 2 VDLLAVGLIIPLVPGHVRK-MGANHIY--VGLLGSIYAGFQLGSGPLIGSLSDLKGRRXX 58
+D + +G+I+P++P +R+ +G ++ G+L ++YA Q+ PL+G SD GRR
Sbjct: 14 LDAMGIGIIMPVLPALLREFVGKANVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPV 73
Query: 59 XXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYG 118
++ Y ++ T +A + + D E+ + +G
Sbjct: 74 LLLSLLGATLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIADV-TPEESRTHWFG 132
Query: 119 KMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFI 159
M A G G+ GP+IGG + + FMF A I G+ F+
Sbjct: 133 MMGACFGGGMIAGPVIGGFAGQLSVQAPFMFAAAINGLAFL 173
>UniRef50_A3UGP9 Cluster: Probable transporter; n=1; Oceanicaulis
alexandrii HTCC2633|Rep: Probable transporter -
Oceanicaulis alexandrii HTCC2633
Length = 415
Score = 62.5 bits (145), Expect = 2e-08
Identities = 86/396 (21%), Positives = 152/396 (38%), Gaps = 34/396 (8%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHI-----YVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
+D L LIIP++P + ++ + + G+ ++A Q P+IG LSD G R
Sbjct: 29 IDALGFALIIPVLPSLLMELTGGGVGEAARWGGIATFVFALMQFVFSPIIGGLSDRFGCR 88
Query: 57 XXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
V + ++GL T A A + D E++ A
Sbjct: 89 PVLLLSLTALMVDFLLMGLAHALVVFFIARLLSGVFAATHSTANAYIADISTPEER-ARR 147
Query: 117 YGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXX 176
+G + A G G LGP +GG + E P F A + G+ NA F+
Sbjct: 148 FGLLGAAMGAGFVLGPALGGLLGELTPRAPFFAAAALAGV----NALYGWFVVPESLKPE 203
Query: 177 XXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYA 236
S +L L + + VL W FL L GF +S A
Sbjct: 204 HRRPFSWKRSNSIATLLRLRRA--EGLGVL-------VWVYFL-SQLAGFVYPAVWSYIA 253
Query: 237 LYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISL 296
+ + + +G ++ GV+ I + F + F L +++L
Sbjct: 254 I---AKFGWTEGEIGISLAAYGVLFVICQ---AVVTPFLMPRIGERRVIWIAFALEAVAL 307
Query: 297 TGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVV 356
GL + +WL+P A+ + +++ +R+ D +G L G + + ++ ++
Sbjct: 308 IGLATAPTTLVLYLWLLP-ALFTGMEGPALQKVMTERTPPDAQGELQGGLSGLGAIVLIL 366
Query: 357 APMVAGFTGQFL----GVSYVIYASLAPTVLGLVMS 388
+P++ +T F GV V++ AP V+ V +
Sbjct: 367 SPLI--YTQLFFAFQNGVGGVVFPG-APFVMAAVFN 399
>UniRef50_Q8VVJ1 Cluster: TetA protein; n=5; Actinomycetales|Rep:
TetA protein - Corynebacterium glutamicum
(Brevibacterium flavum)
Length = 407
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/156 (26%), Positives = 71/156 (45%), Gaps = 5/156 (3%)
Query: 2 VDLLAVGLIIPLVPGHVRKMG----ANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRX 57
+D +GL++P++P + + G A + VG+L ++YA Q P++G+LSD GRR
Sbjct: 20 LDAAGMGLVMPILPALLHEAGVTADAVPLNVGVLIALYAVMQFIFAPVLGTLSDRFGRRR 79
Query: 58 XXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIY 117
+V Y VL T T + ++ D Q+ A+ +
Sbjct: 80 VLLVSLAGATVDYLVLATTSALSVFYIARAVAGITGATNAVTATVIADITPPHQR-AKRF 138
Query: 118 GKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFI 153
G ++A G G+ GP +GG +P+ F+ A +
Sbjct: 139 GLLSACYGGGMIAGPAMGGLFGAISPHLPFLLAALL 174
>UniRef50_A6U8Y2 Cluster: Major facilitator superfamily MFS_1; n=8;
Rhizobiales|Rep: Major facilitator superfamily MFS_1 -
Sinorhizobium medicae WSM419
Length = 421
Score = 62.1 bits (144), Expect = 2e-08
Identities = 43/169 (25%), Positives = 74/169 (43%), Gaps = 6/169 (3%)
Query: 2 VDLLAVGLIIPLVPGHVRKM-----GANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
+D++ + +I+P++P ++ ++ G I G L +Y+ Q PLIG+LSD GRR
Sbjct: 20 LDIMGIAIIVPVLPSYLEELTGADVGEAAIDGGWLLLVYSAMQFFFAPLIGNLSDRFGRR 79
Query: 57 XXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
++ + L + A A + D N+E + A+
Sbjct: 80 PILLASVLTFAIDNLICALATSYWMLFIGRSLAGISGASFGTASAYIADVSNDENR-AKN 138
Query: 117 YGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALV 165
+G + G G LGP+IGG + E P F A + + F+ A L+
Sbjct: 139 FGLIGIAFGTGFALGPVIGGVLGELGPRVPFYGAAALSFLNFVMGAFLL 187
>UniRef50_Q0W242 Cluster: Putative permease; n=1; uncultured
methanogenic archaeon RC-I|Rep: Putative permease -
Uncultured methanogenic archaeon RC-I
Length = 409
Score = 61.7 bits (143), Expect = 3e-08
Identities = 77/383 (20%), Positives = 149/383 (38%), Gaps = 18/383 (4%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
L +I+P++P + + MGA+ +GLL + Y+ QL P +G LSD GR+
Sbjct: 23 LGFSVIMPVLPYYSQSMGASAFDLGLLMASYSVMQLIFTPFLGELSDRVGRKPVFLIGLF 82
Query: 65 XCSVAYTVLGL-TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAI 123
V++ + G T + A + D +++++ I G + A
Sbjct: 83 GYGVSFLIYGFATQLWMLFAARMIGGILSGGIYPASLAYIADITSHKER-GRIMGMLGAS 141
Query: 124 SGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXX 183
SG+G+ GP + G + F IA F F L
Sbjct: 142 SGLGMIFGPALSGGLSIWGLTVPFFTIA---AASFGFVVLGYLLLEESRSVDVHRIRPGK 198
Query: 184 XDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTY 243
+L+ L L+ F +L ++ S + +F Y + F + S + T
Sbjct: 199 VSILAP-LRSRLWILF--LLALLVTLLMSGFQSVFAYYLMGRFGVMDTPSAMPVLGTTMM 255
Query: 244 DLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSI 303
P + + + G+ G I G + + + + + + S ++ +
Sbjct: 256 VTGPTIMAIMFTVMGITGVICQ---GILLGMTIEMIGERHTVITGMFIAAASFFLILAAT 312
Query: 304 NVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGF 363
+ + +++ LA+G + +V KR+D +H+G +G S S+ + P +
Sbjct: 313 ELVSLMMFSCTLALGTGLVTPCLNSLVSKRTDEEHQGAAMGVIGSYNSVGRIAGPPLG-- 370
Query: 364 TGQFLGVSYVIYASLAPTVLGLV 386
G+S+ ++ L T+LGL+
Sbjct: 371 -----GLSFDVHMGLPFTILGLL 388
>UniRef50_A0Z2L4 Cluster: Multidrug-efflux transporter; n=1; marine
gamma proteobacterium HTCC2080|Rep: Multidrug-efflux
transporter - marine gamma proteobacterium HTCC2080
Length = 405
Score = 61.3 bits (142), Expect = 4e-08
Identities = 39/149 (26%), Positives = 73/149 (48%), Gaps = 3/149 (2%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
+VDL+ G++IP++P +G + + V + +IY+ +GP G LSD GR+
Sbjct: 19 VVDLIGFGILIPILPFMSPALGGDEMDVAFVIAIYSLCAGIAGPFWGGLSDRIGRKQVLM 78
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
+++Y ++G+ + +A AL+ D + ++A+ G +
Sbjct: 79 VCLFGGALSYGMIGVASELWMLYAARAVGGVMAGSLPVASALMADV-SAPHRRAKAMGLV 137
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMF 149
G+G+ LGP+IGG + PNG F++
Sbjct: 138 GTAFGLGLILGPVIGGVLA--GPNGTFLW 164
>UniRef50_A7D0E0 Cluster: Major facilitator superfamily MFS_1; n=1;
Halorubrum lacusprofundi ATCC 49239|Rep: Major
facilitator superfamily MFS_1 - Halorubrum lacusprofundi
ATCC 49239
Length = 453
Score = 61.3 bits (142), Expect = 4e-08
Identities = 40/150 (26%), Positives = 64/150 (42%), Gaps = 11/150 (7%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DL+ G++IP++P +VR G + ++GLL + Y+ Q + P +G LSD GRR
Sbjct: 38 IDLVGFGIVIPILPFYVRSFGVSDAFIGLLAASYSLAQFLAAPTLGRLSDRIGRRPVLLA 97
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQML----------AKALVPDYENNEQ 111
VA+ G ++ L A+A V D +
Sbjct: 98 SLATAGVAWVTFGYAGESGARFGTAAALATLFASRTLAGAMGGNIAAAQAYVADITPRD- 156
Query: 112 KQAEIYGKMAAISGVGITLGPMIGGHIMED 141
++A G + A +G GP IGG + D
Sbjct: 157 RRAGALGLVGASFALGFVFGPAIGGLLAAD 186
>UniRef50_Q846S5 Cluster: Adventurous gliding motility protein P;
n=3; Cystobacterineae|Rep: Adventurous gliding motility
protein P - Myxococcus xanthus
Length = 371
Score = 60.9 bits (141), Expect = 6e-08
Identities = 45/156 (28%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DL+ G++IP + + + GA+ VGLL S+++ QL S P++G LSD GRR
Sbjct: 16 LDLIGFGILIPQLGVYGVRFGASPFTVGLLISVFSLMQLVSAPILGRLSDRYGRRPVLLV 75
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
+AY + A+A+V D + +A G +
Sbjct: 76 SQVGSLLAYLLFAFAQSLPLLFLARVIDGISGGNISTAQAVVADI-TTPKDRARGMGVIG 134
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAF-MFIAFIVGI 156
A G+G LGP +GG + N A +F A +V I
Sbjct: 135 AAFGLGFVLGPALGGFLGAWGGNLAIGLFAAGLVAI 170
>UniRef50_Q8F6D6 Cluster: Tetracycline resistance protein, class A;
n=4; Bacteria|Rep: Tetracycline resistance protein,
class A - Leptospira interrogans
Length = 409
Score = 60.1 bits (139), Expect = 1e-07
Identities = 78/395 (19%), Positives = 158/395 (40%), Gaps = 30/395 (7%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHI-----YVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D++ G+IIP++P ++++ + Y GLL Y+ Q P +G LSD GR
Sbjct: 21 LIDVIGFGIIIPVLPKLIQELTHGTLSQAAWYGGLLMFAYSFVQFVCAPFVGGLSDRYGR 80
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R ++ Y L + A + D E K+A+
Sbjct: 81 RPVLLASLFGFTLDYLFLAFAPSIFWLFVGRVLAGIMGASFTTGYAYIADISPPE-KRAQ 139
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXX 175
+G + A G G +GP+IGG + + F+ A + I ++F ++
Sbjct: 140 NFGILGAAFGFGFIIGPVIGGILGQYGSRAPFLAAAALTLINWLFGFFIL-------PES 192
Query: 176 XXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNY 235
+ N + SL N + ++ + + FL G + NY
Sbjct: 193 LTPENRRKFEWQKANPIGSLINLKRYPMIIGLVVAF------FLMNVAAHSVQGTW--NY 244
Query: 236 ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLS-I 294
Y + + VGY + GV+G + + G + + + +S+++ L LS +
Sbjct: 245 --YTMEKFQWNEAMVGYSL---GVVGLVYAITQGGLIRIILPALGQN-KSIYLGLALSGL 298
Query: 295 SLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSG 354
++ + ++LIP +G ++ ++ + + +G L GA S+ S++
Sbjct: 299 GYALFALATQSWMMFVFLIPYCLG-GIAMPPLQGIMSSQVPSNEQGELQGALTSLMSVTA 357
Query: 355 VVAP-MVAGFTGQFLGVSYVIYASLAPTVLGLVMS 388
++ P ++ G F +Y+ AP +G +++
Sbjct: 358 ILGPILMTGLFSYFTAKGTPVYSPEAPLWMGTILT 392
>UniRef50_Q89NI8 Cluster: Bll3850 protein; n=1; Bradyrhizobium
japonicum|Rep: Bll3850 protein - Bradyrhizobium
japonicum
Length = 408
Score = 59.7 bits (138), Expect = 1e-07
Identities = 34/138 (24%), Positives = 62/138 (44%), Gaps = 1/138 (0%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
VD +G+I+PL+P + +++GA +G L S+YA QL +GP++G LSD GRR
Sbjct: 30 VDATGMGIILPLLPFYSQRLGATPFQLGALISVYAVCQLVAGPVVGMLSDRYGRRKVLLV 89
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
+ + +L + +A A ++ ++ + G +
Sbjct: 90 SQIGTFIGFVLLAVAGNLTMVFLARIIDGLTSGNISVAHAYAAEHSAPATRK-QALGMTS 148
Query: 122 AISGVGITLGPMIGGHIM 139
G G+ LGP + ++
Sbjct: 149 GAIGTGLLLGPALSSFLV 166
>UniRef50_Q9RN46 Cluster: 12-TMS multidrug efflux protein homolog;
n=4; Proteobacteria|Rep: 12-TMS multidrug efflux protein
homolog - Salmonella typhi
Length = 413
Score = 59.3 bits (137), Expect = 2e-07
Identities = 76/392 (19%), Positives = 164/392 (41%), Gaps = 35/392 (8%)
Query: 10 IIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVA 69
++ ++P ++R+MG + + +G++ + A Q + PLIG LSD GR+ +++
Sbjct: 39 VMSVLPFYIREMGGSPLIIGIIIATEAFSQFCAAPLIGHLSDRVGRKRILIVTLAIAAIS 98
Query: 70 YTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGIT 129
+L A A + D + ++ I G + G+G
Sbjct: 99 LLLLANAQCILFILLARTLFGISAGNLSAAAAYIADCTHVRNRRQAI-GILTGCIGLGGI 157
Query: 130 LGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSE 189
+G + G + + GA ++ AFI+ + AALV S
Sbjct: 158 VGAGVSGWLSRISL-GAPIYAAFIL----VLGAALVAIWGLKDPSTTSRTTDKIAS-FSA 211
Query: 190 NLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTY-----D 244
+L + + +++ ++ FA G+Y S ++L T+
Sbjct: 212 RAILKM--PVLRVLIIVMLCHF--------------FAYGMYSSQLPVFLSDTFIWNGLP 255
Query: 245 LSPKYVGYVISFQGVMGS-ISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLT-GLIVS 302
PK + Y++ GV+ + + +G+++ ++ + L L LL + LT G+ +
Sbjct: 256 FGPKALSYLLMADGVINIFVQLFLLGWVSQYFS---ERKLIILIFALLCTGFLTAGIATT 312
Query: 303 INVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG 362
I V + I I +A +A+++ L + +G +IG + ++ +++ ++P++ G
Sbjct: 313 IPVLIFAIVCISIA--DALAKPTYLAALSVHVSPARQGIVIGTAQALIAIADFISPVLGG 370
Query: 363 FTGQFLGVSYVIYASLAPTVLGLVMSYHYRTK 394
F + I +++ ++GLV + Y +K
Sbjct: 371 FVLGYALYGVWIGIAISVAIIGLVTAMIYLSK 402
>UniRef50_Q6MQ30 Cluster: Tetracycline-efflux transporter; n=1;
Bdellovibrio bacteriovorus|Rep: Tetracycline-efflux
transporter - Bdellovibrio bacteriovorus
Length = 367
Score = 59.3 bits (137), Expect = 2e-07
Identities = 76/370 (20%), Positives = 144/370 (38%), Gaps = 34/370 (9%)
Query: 27 YVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXX 86
Y G SIYA Q + PL+G+LSD GRR Y ++
Sbjct: 14 YFGYFISIYALMQFLASPLLGALSDRFGRRSVLLISLLVAGFDYILMAYAPTLEILFAGR 73
Query: 87 XXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGA 146
+A A + D N+E + A +G + A G+G +GP IGG + P
Sbjct: 74 IIAGLTGANITVAMAYIADVSNDENRSAN-FGMVGAAFGLGFIIGPAIGGLLGHLGPEYP 132
Query: 147 FMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVL 206
F+ A + + F F ++ D+ N + SL + ++
Sbjct: 133 FLVAAALNLLNFFFGLFIL-------PESLPKNLRRKIDLRRTNPLYSLLGVLRSKHLLA 185
Query: 207 YSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSY 266
+ ++ + L G + S + LY +T Y + VG ++ G++ +++
Sbjct: 186 LLL-------VYFFFQLAG---QTHPSIWTLYTETRYGWTTAQVGLSLAVVGLLSALAQG 235
Query: 267 FIG--YINSF--YKKDVDYSLRSLHVFLLLSISLTG-LIVSINVYNYVIWLIPLAMGNAV 321
++ I F ++ V + F+ ++ G ++ +I + + V W P A+ + +
Sbjct: 236 WLTRLVIPKFGEHRTVVIGAFGYAVSFIFYGMATEGWMMYAILILSAVFWTSPPALQSLI 295
Query: 322 SRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG--FTGQFLGVSYVIYASLA 379
S ++ +G L G+ S+ SL+ ++ P+V F G +Y A
Sbjct: 296 SH---------KTPPQEQGELQGSLVSLSSLAAIITPLVTTKLFAHFSSGNPGTLYLPGA 346
Query: 380 PTVLGLVMSY 389
P G ++ +
Sbjct: 347 PYYFGALICF 356
>UniRef50_Q0W1K3 Cluster: Putative permease; n=1; uncultured
methanogenic archaeon RC-I|Rep: Putative permease -
Uncultured methanogenic archaeon RC-I
Length = 410
Score = 59.3 bits (137), Expect = 2e-07
Identities = 74/360 (20%), Positives = 136/360 (37%), Gaps = 14/360 (3%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
L G+++P+ + MGA+ + +GLL + + Q P G LSD GR+
Sbjct: 20 LGFGIVVPVFGYLTKDMGASALDLGLLMATMSLMQFLCAPTWGKLSDRIGRKPVMLIGLF 79
Query: 65 XCSVAYTVLGL-TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAI 123
++++ + G T A V D + E + ++ G M A
Sbjct: 80 GFALSFILTGFSTQLWMLFAAQILGGLLSAGIWPAVLAYVTDISSPEDR-GKLMGFMGAA 138
Query: 124 SGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXX 183
SG+GI +GP I + F A I + A L+
Sbjct: 139 SGLGIIVGPAISSILAGWGLTVPFFAAAAIALATMLMGAVLLPESLQKGKHISKGPKVAL 198
Query: 184 XDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTY 243
D L L + F SF + Y+ + + +L A + N+ + L
Sbjct: 199 LDTLKTPLGMIFFIMLMVSFAGACLDGTATYFIMDKF-SLTEAASSMPVLNFTMTL---- 253
Query: 244 DLSPKYVGYVISFQGVMGSISSYFIG-YINSFYKKDVDYSLRSLHVFLLLSISLTGLIVS 302
P +G + + G+M IS +G I + +K+ + +L+++ + + S
Sbjct: 254 -TGPNVMGIIFTIMGIMSVISQLAVGPLIQKYGEKNT-----MVFGLILVAVGMMCMPFS 307
Query: 303 INVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG 362
+ + VI + + +G + +V K++ D G ++G S S+ V+ P V G
Sbjct: 308 MGLATLVITVSVMGVGMNLVNPAVNTLVSKQAPPDRIGAMMGLLGSFNSIGRVLGPSVGG 367
>UniRef50_Q89MY8 Cluster: Tetracycline resistance protein; n=7;
Bradyrhizobiaceae|Rep: Tetracycline resistance protein -
Bradyrhizobium japonicum
Length = 462
Score = 58.8 bits (136), Expect = 2e-07
Identities = 40/152 (26%), Positives = 68/152 (44%), Gaps = 6/152 (3%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHI-----YVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D+LA+G+I+P++P + N GL G+ +A Q P++G+LSD GR
Sbjct: 67 LLDMLALGVIMPILPKLIESFVDNDTAHAARIFGLFGTAWALMQFVFSPVLGALSDRFGR 126
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R + Y ++ L + A A + D E++ A
Sbjct: 127 RPVVLLSNFGLAADYVLMALAPSLVWLFIGRVISGITSASISTAFAYIADITPPERRAA- 185
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAF 147
I+G++ A G G LGP +GG + + +P F
Sbjct: 186 IFGRIGAAFGAGFILGPALGGLLGDVDPRLPF 217
>UniRef50_Q2G331 Cluster: Major facilitator superfamily MFS_1; n=1;
Novosphingobium aromaticivorans DSM 12444|Rep: Major
facilitator superfamily MFS_1 - Novosphingobium
aromaticivorans (strain DSM 12444)
Length = 405
Score = 58.8 bits (136), Expect = 2e-07
Identities = 90/400 (22%), Positives = 152/400 (38%), Gaps = 39/400 (9%)
Query: 1 MVDLLAVGLIIPLVPGHVRKM-----GANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
M+D+L G++ P++PG + ++ G Y G LG+ YA Q P+IG+LSD GR
Sbjct: 15 MIDMLGFGIVTPVLPGLIIELTRVDIGTAAEYAGWLGAGYATMQFVFAPVIGNLSDRFGR 74
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R + Y + + + A A + D E K+A
Sbjct: 75 RPVLLAAILMLGLDYLLQAMAPHFWWLIIGRLLAGVTGASFSAAYAYIADVTPPE-KRAA 133
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXX 175
+G M G G +GP +GG + +P F + + F+F + FL
Sbjct: 134 NFGMMGLAFGFGFVVGPAMGGLLGAISPRLPFYAASALALTNFVFG---MFFL----RES 186
Query: 176 XXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNY 235
D N + SL +S VL+ + W + A VY + +
Sbjct: 187 LAPENRRPFDWRRANALSSLRALRGRSRTVLWFVAALGAWQL---------AHVVYPAVW 237
Query: 236 ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSIS 295
+ Y S + VG ++ G ++ F + ++L L + +
Sbjct: 238 PYFAIAAYGFSTRDVGLALAMVGFSSALVQGF----------GLRFALPRLGERRAVVLG 287
Query: 296 LTGLIVSINVYNYV--IWLIPLAMG-NAVSRLVTLEMVLKRS---DGDHRGTLIGASNSV 349
+ GL S +YN W + LA+ A+ V + S D +G L GA S+
Sbjct: 288 VAGLCASAVLYNLAQHTWQVYLAIAVGALQGFVQPPIAAFNSRAVDARSQGELQGAVQSI 347
Query: 350 RSLSGVVAPMVAGFT-GQFLGVSYVIYASLAPTVLGLVMS 388
S++ +V P + T +F G ++ P +L +S
Sbjct: 348 GSIAAIVGPPLYTQTLARFSGPHAIVNLPGMPMLLSAAIS 387
>UniRef50_Q21E97 Cluster: Major facilitator superfamily MFS_1; n=1;
Saccharophagus degradans 2-40|Rep: Major facilitator
superfamily MFS_1 - Saccharophagus degradans (strain
2-40 / ATCC 43961 / DSM 17024)
Length = 413
Score = 57.6 bits (133), Expect = 5e-07
Identities = 76/372 (20%), Positives = 145/372 (38%), Gaps = 22/372 (5%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
++D++ V L+ P+ V++ + I + +L ++Y+ Q + P +G L D GRR
Sbjct: 16 LLDIMGVSLLWPVAAFIVQQYSNDAIMLTVLTALYSAAQFFAAPFMGRLGDSYGRRPVLI 75
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
+ Y + G+ Q +A A + D E + A+ +
Sbjct: 76 ISLLGSCIGYIMFGVGGALWVLLISRLLDGFTAGNQSVAGAYIADVSTPETR-AKNFTLF 134
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
GV + GP +G E + + F+ AA +C L
Sbjct: 135 GMAWGVALVAGPALGAVFGEIS----------LAAPAFL--AATLCLLAALLSYFYLPES 182
Query: 181 XXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
+ S + L+ N F ++ ++ IF+ L F + S +LYL
Sbjct: 183 LARENRNSTPIKLADINPFT---TIIKLLSKPVLGSIFVVLILFNFVFNGFSSTESLYLV 239
Query: 241 TTYDLSPKYVGYVISFQGV-MGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGL 299
+ +P +G +++F G+ + +I I F + V ++ SL + L + ++T +
Sbjct: 240 EKFSATPLQLGGLLTFAGLSLVAIQKILPPLIKRFGHQRV--AVVSL-IALAIMATITSI 296
Query: 300 IVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPM 359
+ N+ V+ L +A G L L + +G L+G + ++ S + V P+
Sbjct: 297 TPAFNLLFGVVSLRTMAAGFLFPILGAL--MSSMVTPKEQGALMGVNTALHSATYVFGPI 354
Query: 360 VAGFTGQFLGVS 371
AG L S
Sbjct: 355 WAGLVYDHLHAS 366
>UniRef50_Q1D6T2 Cluster: Putative multidrug resistance protein;
n=1; Myxococcus xanthus DK 1622|Rep: Putative multidrug
resistance protein - Myxococcus xanthus (strain DK 1622)
Length = 400
Score = 57.6 bits (133), Expect = 5e-07
Identities = 47/167 (28%), Positives = 75/167 (44%), Gaps = 9/167 (5%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DL+ GLIIPL+P +V MG G+L ++++ QL + P++G LSD GRR
Sbjct: 15 LDLVGFGLIIPLLPFYVESMGGTATTAGVLLALFSFAQLVASPVLGRLSDRVGRRPVILL 74
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQ---MLAKALVPDYENNEQKQAEIYG 118
+++ + + T +A V D +E +A G
Sbjct: 75 SLLGNAISMALFAYSTHVQWLPWLFASRLLAGATAGNLAACQAAVADV-TDESGRAAGMG 133
Query: 119 KMAAISGVGITLGPMIGG--HI---MEDNPNGAFMFIAFIVGICFIF 160
+ A G+G+ LGP+IG H+ GA M A ++G+ F F
Sbjct: 134 LVGAGIGLGMVLGPVIGSLLHVHGAWAPPLAGAVMAAAAMLGVLFFF 180
>UniRef50_A4ING5 Cluster: Multidrug-efflux transporter; n=1;
Geobacillus thermodenitrificans NG80-2|Rep:
Multidrug-efflux transporter - Geobacillus
thermodenitrificans (strain NG80-2)
Length = 404
Score = 57.6 bits (133), Expect = 5e-07
Identities = 76/365 (20%), Positives = 145/365 (39%), Gaps = 36/365 (9%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
+ +GLIIP++P + ++G + VGLL ++++ Q P+ G ++D GR+
Sbjct: 23 IGIGLIIPIMPTFIEQLGISGGTVGLLVAVFSLTQFLFSPVAGRMADAVGRKKLIVSGML 82
Query: 65 XCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLA-KALVPDYENNEQKQAEIYGKMAAI 123
+ + G M A A D NE++ A I G + A
Sbjct: 83 LFAFSEWQFGYADHVFEMFFSRVIGGISAALTMPAVMAYAADITTNEERAAGI-GYINAA 141
Query: 124 SGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXX 183
+G +GP IGG++ E F A VG+ AA++ L
Sbjct: 142 ITMGFMIGPGIGGYMAEWGIRVPFN-CAAAVGVM----AAVITALFLPESHSSASTGTVQ 196
Query: 184 XDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTY 243
D + FV L ++ Y+ L + F + + + ++L++ +
Sbjct: 197 KDHV-------------PFFVQLAQVHRQPYFFSLLIIFALSFGLANFETIFSLFVDHRF 243
Query: 244 DLSPKYVGYVISFQGVMGSI-----SSYFIGYINSFYKKDVDYSLRSLHVFL-LLSISLT 297
SPK + +I+ + G + + +G+ L +L + L LL+ + T
Sbjct: 244 GFSPKEIALIITIGSIGGPLVQLTTFGWLLGHFGEQRVVSACLLLSALFIVLTLLASTWT 303
Query: 298 GLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVA 357
L+V+ + I ++ A+ +S++ D +G + G +++ SL ++
Sbjct: 304 MLLVATVLVFLAIDILRPAVSTQMSKI----------DETQQGYIAGLNSAFTSLGNIIG 353
Query: 358 PMVAG 362
P VAG
Sbjct: 354 PAVAG 358
>UniRef50_Q4ZVR8 Cluster: General substrate transporter:Major
facilitator superfamily; n=2; Pseudomonas syringae|Rep:
General substrate transporter:Major facilitator
superfamily - Pseudomonas syringae pv. syringae (strain
B728a)
Length = 411
Score = 57.2 bits (132), Expect = 7e-07
Identities = 36/164 (21%), Positives = 66/164 (40%), Gaps = 6/164 (3%)
Query: 2 VDLLAVGLIIPLVPGHVRKM---GANHIYV--GLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
+D+L +GL IP++P + + H+ + G+ ++Y+ Q PL+G+LSD GRR
Sbjct: 23 LDVLGIGLAIPVMPTLIATIWPSSTEHVSLALGVALTLYSAMQFLCAPLLGALSDCHGRR 82
Query: 57 XXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
+ + G A A + D EQ+
Sbjct: 83 PILLLALAGMCLGNLMAGFAGSLTVLLIGRAIAGITAANIATAMAYIADISEGEQR-THF 141
Query: 117 YGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIF 160
YG ++ + + GP+IGG + P+ F+ + I ++
Sbjct: 142 YGAAGSVIAIALVFGPVIGGGLASYGPHLPFLVAGGLAAINLLY 185
>UniRef50_Q9KBZ9 Cluster: Multidrug-efflux transporter; n=2;
Bacillaceae|Rep: Multidrug-efflux transporter - Bacillus
halodurans
Length = 409
Score = 56.8 bits (131), Expect = 9e-07
Identities = 68/364 (18%), Positives = 147/364 (40%), Gaps = 26/364 (7%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+ + + G+IIP++P ++ +G GL+ +I+AG QL P+ G +D GRR
Sbjct: 18 IAIASFGIIIPILPAYLESIGEGGTAAGLMIAIFAGAQLVMSPVAGKWTDQYGRRYMIIL 77
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLA-KALVPDYENNEQKQAEIYGKM 120
+++ V + A A V D +++ A+ +
Sbjct: 78 GLGGLTLSMFVFYFFDSIWWLYASRVVGGVGAALLIPAIFAYVADITTIDER-AKGNSLV 136
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
+A +G +GP IGG + + + A + + +F+ L+
Sbjct: 137 SAAMSLGFVVGPGIGGFLADFGLKMPILLSAILSLVAVLFSIMLL-----KESQTEEAKE 191
Query: 181 XXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
V LV L S K+ + + I + + Y++++G L++
Sbjct: 192 LTAEQVSESPLVKQLIQSVKKPYFIPLVITLVMSFGLMAYESILG-----------LFVD 240
Query: 241 TTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLI 300
+ +P + +++ G + I F+ ++ V + + L L ++ G +
Sbjct: 241 NQFGATPGQIAILLTSIGTISVIVQLFV------VERLVRWLGERTVLSLFLGVASFGFL 294
Query: 301 VSINVYNY-VIWLIPLAMGNAVSRL-VTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAP 358
+S+ +Y + + + + + A S L L ++ + G+ +G +G +N+ S+ V+ P
Sbjct: 295 LSLFAPSYGMFFAVTMFIFLATSILRPVLTTLISKLAGNEQGFAMGMNNAYMSIGNVLGP 354
Query: 359 MVAG 362
+AG
Sbjct: 355 ALAG 358
>UniRef50_Q5WGK5 Cluster: Major facilitator (MFS) superfamily
multidrug resistance protein; n=1; Bacillus clausii
KSM-K16|Rep: Major facilitator (MFS) superfamily
multidrug resistance protein - Bacillus clausii (strain
KSM-K16)
Length = 403
Score = 56.8 bits (131), Expect = 9e-07
Identities = 72/364 (19%), Positives = 143/364 (39%), Gaps = 25/364 (6%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+ + VGL+IP++P ++ +G + VGLL ++++ Q P GS SD GR+
Sbjct: 21 IGFVGVGLVIPIMPTYMNVLGISGTIVGLLVAVFSLTQFLVAPYAGSWSDRYGRKWIIVA 80
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLA-KALVPDYENNEQKQAEIYGKM 120
+V+ + GL M A A V D E + +
Sbjct: 81 GLLLFAVSELLFGLATNAVLLFISRLLGGVSVAFIMPAVMAYVVDITTEEDRGMGMGWIN 140
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
AAIS G +GP IGG ++E F A + + + ++ L
Sbjct: 141 AAIS-TGFIIGPAIGGFLVEYGMRVPFFAAAGAAALSAVVSMSI---LPESLDKNKLPAP 196
Query: 181 XXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
D E+ + L S++ + Y+ L + + + + L++
Sbjct: 197 EARMD-RKESQLAQLAKSYR-----------TPYFTGLLIILITSLGLSQFETVLGLFVD 244
Query: 241 TTYDLSPKYVGYVISFQGVMGSIS--SYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTG 298
Y +P + ++I ++G++ + F IN +K + +++ L++++ +
Sbjct: 245 HKYSYTPNEIAWLIMIGAIVGAVMQLTLFGRLINWIGEKKL-----TVYCLLVMAVFMVA 299
Query: 299 LIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAP 358
I S + V+ + + + R + R G+ +G + G + S SL + P
Sbjct: 300 TIFSAQYWMMVVSVTLVFLAVDFVR-PAISTYFSRIAGNEQGLVAGLNASYTSLGNIGGP 358
Query: 359 MVAG 362
++AG
Sbjct: 359 ILAG 362
>UniRef50_Q9Z479 Cluster: Drug efflux protein TetA; n=3;
Proteobacteria|Rep: Drug efflux protein TetA -
Agrobacterium tumefaciens
Length = 394
Score = 56.8 bits (131), Expect = 9e-07
Identities = 73/363 (20%), Positives = 136/363 (37%), Gaps = 28/363 (7%)
Query: 2 VDLLAVGLIIPLVPGH-VRKMGANHI--YVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXX 58
+D + GLI P++P V G I G++ ++A Q P++G+LSD GRR
Sbjct: 14 LDAIGAGLIFPILPDILVEVTGGGDIGFLYGVMLGVFAVMQFVFSPILGALSDRFGRRPV 73
Query: 59 XXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYG 118
+ Y V+ + +A A + D EQ+ A+ +G
Sbjct: 74 LLLSLAGTLLDYLVMAFSPLGWVLVVGRAMAGITSANMAVASAYITDITPAEQR-AQRFG 132
Query: 119 KMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXX 178
+ A+ +G +GP+IGG I F+ A G+ N + F+
Sbjct: 133 TVGAVMSLGFIIGPVIGGVIGAWWLRAPFLVAALFNGL----NLFVALFVLPESRKAGPG 188
Query: 179 XXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALY 238
F +++ N+ + + G + + + LY
Sbjct: 189 KFA--------------FKELNPLAPLVWLWNFKPLLPLVTVSVVFGLVAAIPGTIWVLY 234
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHV-FLLLSISLT 297
+ ++G +S GV G+++ F+ + ++ D + V F +L+ L
Sbjct: 235 GAERFGWDSVHMGLSLSVFGVSGALAQAFL--VGPLSRRFGDLGTLMIGVGFDMLAYMLM 292
Query: 298 GLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVA 357
+ + Y + PL V+ +V R D +G L G S+ SL+G++
Sbjct: 293 A-FANQSWMGYAV--APLFALGGVAMPALQSLVTSRVSDDQQGQLQGVLASLMSLAGIIG 349
Query: 358 PMV 360
P++
Sbjct: 350 PVL 352
>UniRef50_Q1GPE1 Cluster: Major facilitator superfamily MFS_1; n=2;
Sphingomonadaceae|Rep: Major facilitator superfamily
MFS_1 - Sphingopyxis alaskensis (Sphingomonas
alaskensis)
Length = 412
Score = 56.8 bits (131), Expect = 9e-07
Identities = 42/157 (26%), Positives = 71/157 (45%), Gaps = 6/157 (3%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGA----NHIYVGL-LGSIYAGFQLGSGPLIGSLSDLKGRR 56
+D + G+I+P++P V ++G + I VG +G + A + P++G+LSD GRR
Sbjct: 16 IDAVGFGIIMPVLPQLVMEVGQIDLPHAIEVGAWIGLVMAVATFLASPVLGNLSDRFGRR 75
Query: 57 XXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
+V Y +L + + A+A + D E++ A
Sbjct: 76 RILLLALGGLAVDYALLTVVETLPWLFVARALSGIFGGSYAAAQAAIADITPPEER-ARN 134
Query: 117 YGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFI 153
+G + A GVG GP IGG + E +P F+ A +
Sbjct: 135 FGFVGAAFGVGFVAGPAIGGFLGEMSPRAPFVAAAIL 171
>UniRef50_A1B6I1 Cluster: Major facilitator superfamily MFS_1; n=1;
Paracoccus denitrificans PD1222|Rep: Major facilitator
superfamily MFS_1 - Paracoccus denitrificans (strain Pd
1222)
Length = 405
Score = 56.4 bits (130), Expect = 1e-06
Identities = 34/135 (25%), Positives = 61/135 (45%), Gaps = 1/135 (0%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
V+ +G+I+PL+P + + GA + +GLL + ++ +L + P++G SDL GR+
Sbjct: 23 VESAGLGMILPLLPFYASEFGATPLTIGLLLASFSLCELLAAPILGKASDLFGRKRLLVA 82
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
++ +L L +A A V D K+ + G ++
Sbjct: 83 SQIGTCASFLLLALAPNLAVVFAARILGGLSAGNISIATAYVSD-RTAPHKRRQAIGFVS 141
Query: 122 AISGVGITLGPMIGG 136
A GVG +GP + G
Sbjct: 142 AAMGVGTMVGPALAG 156
>UniRef50_Q97L04 Cluster: Permease, probably tetracycline resistance
protein; n=30; Firmicutes|Rep: Permease, probably
tetracycline resistance protein - Clostridium
acetobutylicum
Length = 411
Score = 56.0 bits (129), Expect = 2e-06
Identities = 83/384 (21%), Positives = 147/384 (38%), Gaps = 35/384 (9%)
Query: 10 IIP-LVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSV 68
+IP LV ++ G I V LL S+YA S P +G+LSD GRR S+
Sbjct: 41 VIPFLVQPYINNPGNQAIIVTLLTSVYAICMFFSAPGLGALSDKYGRRPVLLVCLLGSSI 100
Query: 69 AYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGI 128
Y + G+ T A D E ++ + +G ++A+ GVG
Sbjct: 101 GYLIFGIGGALWVLFAGRIIDGITGGTISTIFAYFADI-IPENERTKYFGWVSAVVGVGT 159
Query: 129 TLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLS 188
+GP +GG + + + F A I + N F ++
Sbjct: 160 IIGPTLGGLLAKFGYSVPLYFGAIIT----LLNVVYGFFF---------MPESLDKNIRL 206
Query: 189 ENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPK 248
+ + N F Q L SI K + + L+ G + ++ + T+ P
Sbjct: 207 KEITFVRLNPFTQ-LANLLSIKSLK--RLLISAFLLWIPNGSLQAVFSQFTIDTFSWKPA 263
Query: 249 YVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLS--ISLTGLIVSINVY 306
+G + S G IS I K V S + + + ++S I + + S Y
Sbjct: 264 IIGLMFSIMGFQDIISQSLI-----MPKLLVKLSDKYIAILGMISEVIGYSLIAASALFY 318
Query: 307 NYVIWLIPL---AMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGF 363
Y +++ + G+++ M+ K D +G + G S S+++L+ ++ P++
Sbjct: 319 FYPLFIAGMFIFGFGDSIFGPSFNGMLSKSVDSSEQGRIQGGSQSIQALARMIGPIIG-- 376
Query: 364 TGQFLGVSYVIYASLAPTVLGLVM 387
G YV P +G+V+
Sbjct: 377 -----GQIYVSLGHATPAFMGIVL 395
>UniRef50_A5FYH1 Cluster: Major facilitator superfamily MFS_1
precursor; n=1; Acidiphilium cryptum JF-5|Rep: Major
facilitator superfamily MFS_1 precursor - Acidiphilium
cryptum (strain JF-5)
Length = 413
Score = 56.0 bits (129), Expect = 2e-06
Identities = 36/142 (25%), Positives = 65/142 (45%), Gaps = 8/142 (5%)
Query: 1 MVDLLAVGLIIPLVPGHVRKM---GAN---HIYVGLLGSIYAGFQLGSGPLIGSLSDLKG 54
++D+LA+ +++P++P + + GA H++ G G+ +A Q + P++G+LSD G
Sbjct: 21 LLDMLAMAIVLPVLPALITGLVGGGAGLSAHVF-GAFGAAWAAMQFIASPMLGALSDRFG 79
Query: 55 RRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQA 114
RR +V +TV+ L A A + D E ++A
Sbjct: 80 RRPVILLSCLGQAVDFTVMALAPSVGWLLAGRILSGASSANIAAANAYISDVTPPE-RRA 138
Query: 115 EIYGKMAAISGVGITLGPMIGG 136
+G + +G LGP +GG
Sbjct: 139 AAFGVSGVAAAIGFVLGPALGG 160
>UniRef50_A3MSL0 Cluster: Major facilitator superfamily MFS_1; n=2;
Pyrobaculum calidifontis JCM 11548|Rep: Major
facilitator superfamily MFS_1 - Pyrobaculum calidifontis
(strain JCM 11548 / VA1)
Length = 388
Score = 56.0 bits (129), Expect = 2e-06
Identities = 36/164 (21%), Positives = 69/164 (42%), Gaps = 1/164 (0%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
++ ++ ++P+ V+ +G + + GLL S + QL S PL G SD GRR
Sbjct: 16 VLHMMGFSAVVPVTSTLVKSLGGDSVVQGLLASAFTLAQLVSAPLWGWASDRLGRRVIIA 75
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
++ + L L T + +A V + E++ A + +
Sbjct: 76 VGLGLAAIGHAGLYLARDLPTAFVARAVSGLGGGTLPVIQAAVLELSRPEERAASM-AQF 134
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAAL 164
A G+G GP++GG + +P F+ A + +++ A+
Sbjct: 135 GAALGIGFVAGPLLGGALSILSPRDPFLAAAVLSATAALWSTAV 178
>UniRef50_Q8F4V6 Cluster: Tetracycline resistance protein; n=4;
Leptospira|Rep: Tetracycline resistance protein -
Leptospira interrogans
Length = 445
Score = 55.6 bits (128), Expect = 2e-06
Identities = 74/340 (21%), Positives = 128/340 (37%), Gaps = 19/340 (5%)
Query: 26 IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXX 85
++ G++ S+Y+ Q P+ G +SD GR+ + Y + +
Sbjct: 78 LFGGIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLS 137
Query: 86 XXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNG 145
+A A + D NE+ +A+ G + A G+G GP GG + N +
Sbjct: 138 RVITGTMGGNISVASAAMADI-TNEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLDF 196
Query: 146 ---AFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNSF--K 200
F + F V A ++ + D+L + + + F K
Sbjct: 197 LKLVFPDLTFTVFPASALAATIIALINLLMILFWFRETFDQKDLLEKKKIHPILGVFTSK 256
Query: 201 QSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVM 260
VVLYSI + + +F + F++ Y S + Y + Y+G +I +
Sbjct: 257 NKEVVLYSIFYFVF--VFAFSGFE-FSINFYLSQFLNYKPIEIGFTFVYIGMIIVL--IQ 311
Query: 261 GSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNA 320
G + G ++ + L + F LL + L N Y I L LA G+A
Sbjct: 312 GGVFRRLSGKVD-------ETKLIRIGTFSLL-VGFFILYFVSNSYQLFISLTFLASGSA 363
Query: 321 VSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMV 360
+ +V S + +GT +G S+ SL +AP V
Sbjct: 364 LLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFV 403
>UniRef50_UPI0001555554 Cluster: PREDICTED: similar to Solute
carrier family 22 (organic cation transporter), member
18, partial; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to Solute carrier family 22 (organic
cation transporter), member 18, partial -
Ornithorhynchus anatinus
Length = 296
Score = 54.4 bits (125), Expect = 5e-06
Identities = 40/160 (25%), Positives = 73/160 (45%), Gaps = 5/160 (3%)
Query: 217 IFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGS-ISSYFIGYINSFY 275
+F K L GF G++ ++ + L + GY++S+ GV I IG + S Y
Sbjct: 115 VFTIKVLSGFPAGIFLIMLSVISVNVFGLEAQQTGYLMSYFGVFQMVIQGLVIGRLTSRY 174
Query: 276 KKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSD 335
+ +L L V +L + L +++ + ++ + + PL G ++T ++ K
Sbjct: 175 SES---ALLRLSVLVLGVVGLAMALMT-TIVHFCLLVPPLLFGLVSLNILTDNILTKAVS 230
Query: 336 GDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIY 375
G ++G V+ L+ V P + GF Q GVS + Y
Sbjct: 231 PMDTGAMLGLCACVQPLTRTVGPTLGGFLYQTFGVSSLGY 270
>UniRef50_A3VN57 Cluster: Permease; n=1; Parvularcula bermudensis
HTCC2503|Rep: Permease - Parvularcula bermudensis
HTCC2503
Length = 441
Score = 54.4 bits (125), Expect = 5e-06
Identities = 38/154 (24%), Positives = 66/154 (42%), Gaps = 6/154 (3%)
Query: 1 MVDLLAVGLIIPLVPGHVRKM-----GANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++ ++ VG+I+P++P + + G + G L YA Q P+IG+LSD GR
Sbjct: 18 LLSMIGVGIILPVMPALLTDLTGFAEGESARLYGYLMFAYAAMQFLFSPVIGALSDQYGR 77
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R + + ++ T A A + D E K+A+
Sbjct: 78 RPVILVSLFFYGIDFLLMAFVPTFGWLVLGRLLSGATAATFSTAGAFIADVSPPE-KRAQ 136
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMF 149
+G + A G+G +GP++GG P+ A +F
Sbjct: 137 NFGIIGAAFGLGFIIGPVLGGLAAAYGPSLAILF 170
>UniRef50_A3CSW8 Cluster: Major facilitator superfamily MFS_1; n=1;
Methanoculleus marisnigri JR1|Rep: Major facilitator
superfamily MFS_1 - Methanoculleus marisnigri (strain
ATCC 35101 / DSM 1498 / JR1)
Length = 403
Score = 54.4 bits (125), Expect = 5e-06
Identities = 38/140 (27%), Positives = 59/140 (42%), Gaps = 2/140 (1%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+D++ GL+IP+ P + ++G +G++ IYAG L +G LSD GRR
Sbjct: 33 MDMMIYGLLIPVFPQYAPRLGVGESVIGIIFGIYAGMLLLFSIPMGLLSDRVGRRPLIVA 92
Query: 62 XXXXCSVAYTVLGL-TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
++A + G T T AL+ D + + E G
Sbjct: 93 GMLLLALATALFGFSTTITHLVAARTVQGVSAAATWSAGLALLAD-TCDPARLGEKMGVA 151
Query: 121 AAISGVGITLGPMIGGHIME 140
+ GVG LGP+ GG + E
Sbjct: 152 LSAVGVGTILGPVAGGLLFE 171
>UniRef50_Q8ZUX8 Cluster: Tetracycline resistance protein; n=1;
Pyrobaculum aerophilum|Rep: Tetracycline resistance
protein - Pyrobaculum aerophilum
Length = 361
Score = 54.0 bits (124), Expect = 7e-06
Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 1/135 (0%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+ +L G++IP++P V+++G G+L SI++ Q+ S PL G+LSD GR
Sbjct: 13 IHMLGFGIVIPVMPYVVKELGGGSEAYGVLVSIFSAVQMVSAPLWGALSDRIGRGPVITL 72
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
++ + T +AL+ D E++ + +
Sbjct: 73 GLALAAIGSAMAYGARSLAELALARAVSGMGGGTLGAVQALIADLSPPERRASNM-ALFG 131
Query: 122 AISGVGITLGPMIGG 136
G+G LGP++GG
Sbjct: 132 VAFGIGFILGPVVGG 146
Score = 34.3 bits (75), Expect = 5.7
Identities = 32/154 (20%), Positives = 64/154 (41%), Gaps = 7/154 (4%)
Query: 224 VGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSL 283
+ A ++ S Y + ++P +G ++ G+ + + + + V Y+
Sbjct: 199 LNLAFSMFESMLVYYAADVFKMAPSDLGVLMLIIGLAVASAQPAVRRLEG----RVAYTT 254
Query: 284 RSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLI 343
+L F+ + G++ ++ + A+G V+ + + G RG
Sbjct: 255 SALAGFVATGAGI-GVLPALGELGLYLGSAVAAVGQMVASSSLFALFSQGERG--RGIGF 311
Query: 344 GASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYAS 377
GA S SL ++ P +AG+ LG SYV YA+
Sbjct: 312 GALQSTASLGRIIGPSLAGWIYLKLGPSYVFYAA 345
>UniRef50_Q0AX92 Cluster: Multidrug-efflux transporter; n=1;
Syntrophomonas wolfei subsp. wolfei str. Goettingen|Rep:
Multidrug-efflux transporter - Syntrophomonas wolfei
subsp. wolfei (strain Goettingen)
Length = 370
Score = 53.6 bits (123), Expect = 9e-06
Identities = 77/388 (19%), Positives = 144/388 (37%), Gaps = 29/388 (7%)
Query: 11 IPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAY 70
+P++P + MGA+ +GLL ++YA Q P GS SD GR+ ++ +
Sbjct: 1 MPILPYYAESMGASAFQLGLLMTVYALCQFIFAPFWGSYSDRVGRKPVLLVGMFGFTLTF 60
Query: 71 TVLGLTXXXXXXXXXXXXXXXXK-QTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGIT 129
+ L T A A++ D + E++ A + G + A G+G+
Sbjct: 61 FIFALANSLWVLFVARIAGGALSCATVPTAMAVMGDTSSPEKRGASM-GMVGASMGMGMI 119
Query: 130 LGPMIGGHIMEDNPNGAFMFIAFI-VGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLS 188
GP IG + + F+ + V ICF C L +
Sbjct: 120 FGPAIGSGLAHISLAAPFVMAGSLSVVICF-------CILFLVKESLPVEDRVSEAQKID 172
Query: 189 ENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPK 248
L K L++ +FL MG +AL+ + P
Sbjct: 173 R---APLLKGLKSPLAFLFTA-------MFLASMAEATNMG----TFALFAEGKLGFGPT 218
Query: 249 YVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNY 308
+G + S G+ + F+ + K + + L+ S S + + ++
Sbjct: 219 SMGLIFSCAGLASVLVQGFV--VGRAINKWGEEKTSGAGIILMAS-SFALFLQAKSLLEL 275
Query: 309 VIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFL 368
+I++ + G + R KR+ G +GT +G SL V+ P + G+ +
Sbjct: 276 IIYMGIFSAGTGLIRPSISAATSKRTTGS-QGTAMGVLQGYDSLGRVIGPSLGGYLLD-M 333
Query: 369 GVSYVIYASLAPTVLGLVMSYHYRTKRK 396
+SY ++++ + L + R++ K
Sbjct: 334 NLSYAYFSAIFFSGLAFLTLLFNRSRGK 361
>UniRef50_Q6V4U1 Cluster: Putative multidrug efflux protein; n=1;
Enterococcus faecium|Rep: Putative multidrug efflux
protein - Enterococcus faecium (Streptococcus faecium)
Length = 395
Score = 53.2 bits (122), Expect = 1e-05
Identities = 67/358 (18%), Positives = 137/358 (38%), Gaps = 22/358 (6%)
Query: 6 AVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXX 65
A GLIIP++P + K N +GLL + Y QL P+ G +D GR+
Sbjct: 24 AFGLIIPILPDFMGKFNTNGQMMGLLVATYGIIQLFLSPIAGRFADRYGRKRIIEIGLIC 83
Query: 66 CSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQML-AKALVPDYENNEQKQAEIYGKMAAIS 124
+++ V + + A A + D E++ + A+IS
Sbjct: 84 LTLSQLVFAFSVHFWLLFLGRFLTGIAVSLLIPGAMACIIDITTEEERAKGLSFLNASIS 143
Query: 125 GVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXX 184
G +GP IGG + +++ F F + L+ F
Sbjct: 144 -FGFVIGPGIGGFLTTYG-----LYVPFYFATVLSFVSFLLSFFLLPETLEKKTEMTKAD 197
Query: 185 DVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYD 244
V + +V + S + +VV + +FLY ++ ++ + + L++ +
Sbjct: 198 TVSPQPMVQQILRSIRVPYVVPLLL-------VFLYSV----SLYIFEAIFGLFVAKQFG 246
Query: 245 LSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSIN 304
+ K + VI+ + + + N + + + + +S L+ +
Sbjct: 247 YTAKDIAMVITIAAFVSVMVQLLL--TNKLVSLFGESKVMN-GTMIAGGVSFLFLLFTTR 303
Query: 305 VYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG 362
+++ ++ L ++ R V + VL + + +G + G +N+ SL VV P++ G
Sbjct: 304 IWSILLLTCLLYTATSILRPV-INTVLSKLANNEQGFIAGMNNAYVSLGSVVGPILGG 360
>UniRef50_A5V1Q7 Cluster: Major facilitator superfamily MFS_1; n=4;
Chloroflexaceae|Rep: Major facilitator superfamily MFS_1
- Roseiflexus sp. RS-1
Length = 428
Score = 52.8 bits (121), Expect = 2e-05
Identities = 81/397 (20%), Positives = 156/397 (39%), Gaps = 47/397 (11%)
Query: 1 MVDLLAVGLIIPLVPGHVRK--------MGANH-IYVGLLGSIYAGFQLGSGPLIGSLSD 51
++DLL +G+++PL+P +++ + AN I VG L + +A Q P++G+LSD
Sbjct: 15 LIDLLGIGIVLPLMPYYLKIVEQSSIPWLAANRAIIVGALMASFALMQFLFTPVLGALSD 74
Query: 52 LKGRRXXXXXXXXXCSVAYTV---------LGLTXXXXXXXXXXXXXXXXKQTQMLAKAL 102
GRR ++Y + LG+ + A+A
Sbjct: 75 RYGRRPILLISVLGSGLSYVLFGFAEYLSFLGVETVLAILFIGRMLSGITGASISTAQAY 134
Query: 103 VPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNA 162
+ D E++ + G + A G+G LGP +GG ++ A F+A G+ F
Sbjct: 135 IADTTTPEERTKGM-GMIGAAFGLGFMLGPALGG-LLSTISLEAPAFVA--AGLAF---- 186
Query: 163 ALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKA 222
A V F + N V L ++S + I IF
Sbjct: 187 ANVIFGYFKLPESLPPERRMVTPMRGMNPVSRLSALLRRSSIRPLLIG------IF---- 236
Query: 223 LVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYS 282
L+ A SN+A++ + P + + G++ + + F + + +
Sbjct: 237 LLNMAFSGLQSNFAVFSDVRFGFGPLDNALIFTLVGLLAVV-------MQGFLIRRLVLA 289
Query: 283 LRSLHVFLLLSISLTGLIVSINVYNYVIWLIP----LAMGNAVSRLVTLEMVLKRSDGDH 338
+ + + G +++ + L P +A+G+ ++ ++ +R D
Sbjct: 290 FGETRLAIAGMTMMAGAFIAVALAPEAWMLFPAVGAIAIGDGMATPALTGLISRRVDAHE 349
Query: 339 RGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIY 375
+G +G + + SL+ + AP++AG T + VS Y
Sbjct: 350 QGATLGGTQGLISLTRIAAPILAGTTFDLINVSAPYY 386
>UniRef50_A3IH26 Cluster: Multidrug resistance protein, putative;
n=1; Cyanothece sp. CCY 0110|Rep: Multidrug resistance
protein, putative - Cyanothece sp. CCY 0110
Length = 423
Score = 52.8 bits (121), Expect = 2e-05
Identities = 73/398 (18%), Positives = 158/398 (39%), Gaps = 18/398 (4%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
++ ++ ++IPL+ + ++ G + LL + +A Q P++GSLSD GR+
Sbjct: 24 INSVSFTIVIPLLYPYAKQFGLSDFQASLLTTAFALSQFLGTPILGSLSDRLGRKSILIV 83
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
VA V +A+A++ D + Q+ + +G +
Sbjct: 84 SLAGTVVANMVASFATVAWLLYAARVLDGLTGGNTSVARAVISDITDASQR-TKAFGIFS 142
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAA---LVCFLXXXXXXXXXX 178
A +G +GP + ++ + P F I+ + G+ F+ +AA + L
Sbjct: 143 ATFRLGFVVGPFL-SYLAQQLP--TFAGISSL-GMSFVVSAAIASIALLLTIVFLPEKRS 198
Query: 179 XXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALY 238
E LS ++ F + S K +F+ L G ++ + +
Sbjct: 199 RRDPHSGTQKEKFRLS-WHDFALG-KIAKSATIPKLGQLFILTFLSGSTFTIFTFAFQPF 256
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTG 298
+ + K + + + G++G IS F + K+ ++L ++ L LT
Sbjct: 257 FLNVLNQNTKRLAIMFAIVGMLGFISQVFA--LEPLSKR---FNLINIIAVTLAIRGLTF 311
Query: 299 LIVSI--NVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVV 356
+++ +VI L A+ N+ + ++ + +G ++G + + S++ +
Sbjct: 312 ILMPAFPTFTAFVIILSIFALVNSFPMPLIDTVLSLNTSPQKQGEVLGINAAYLSIANAI 371
Query: 357 APMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTK 394
PM++G F ++ + T+L + H +TK
Sbjct: 372 GPMISGLLVSF-DYQTPLWITGGLTLLVAGFATHLKTK 408
>UniRef50_Q96BI1 Cluster: Organic cation transporter-like protein 2;
n=19; Eutheria|Rep: Organic cation transporter-like
protein 2 - Homo sapiens (Human)
Length = 408
Score = 52.4 bits (120), Expect = 2e-05
Identities = 39/183 (21%), Positives = 85/183 (46%), Gaps = 5/183 (2%)
Query: 217 IFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSIS-SYFIGYINSFY 275
IFL K G++ +++ + L GY++SF G++ ++ IG ++S +
Sbjct: 227 IFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHF 286
Query: 276 KKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSD 335
++V S+ VF+++ +++ + +V+++ + + L +VT M++K
Sbjct: 287 SEEV-LLRASVLVFIVVGLAMAWM---SSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVS 342
Query: 336 GDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTKR 395
GT++G SV+ L + P V G + GV + +A L L++ + +
Sbjct: 343 TSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKPMPQ 402
Query: 396 KVD 398
+ D
Sbjct: 403 RKD 405
Score = 46.4 bits (105), Expect = 0.001
Identities = 32/141 (22%), Positives = 57/141 (40%), Gaps = 5/141 (3%)
Query: 3 DLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXX 62
+L + + +VP RK+G + I G L + + QL GP+ G +D +G R
Sbjct: 20 ELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLS 79
Query: 63 XXXCSVAYTVLGLTXX----XXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYG 118
Y +L T A+ ++ D E++ A + G
Sbjct: 80 FLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAAL-G 138
Query: 119 KMAAISGVGITLGPMIGGHIM 139
++ GVG+ LG ++GG ++
Sbjct: 139 RLGLCFGVGVILGSLLGGTLV 159
>UniRef50_Q9A8S0 Cluster: Tetracycline resistance protein; n=3;
Alphaproteobacteria|Rep: Tetracycline resistance protein
- Caulobacter crescentus (Caulobacter vibrioides)
Length = 586
Score = 52.0 bits (119), Expect = 3e-05
Identities = 37/156 (23%), Positives = 63/156 (40%), Gaps = 6/156 (3%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVG-----LLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D+L++G++IP++P V+ G L + + Q P++G LSD GR
Sbjct: 192 ILDVLSLGVMIPVLPNLVKAFGGGDTAAAADWNVLFATTWGVMQFICSPILGLLSDRFGR 251
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R + + + + A A V D E + A+
Sbjct: 252 RPVILTSIFGLGIDFLFMAFAPNLWWLFIGRIFNGMTAASFSTASAYVADVTTPENR-AK 310
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIA 151
+G M A G+G T GP +GG + E + F+ A
Sbjct: 311 GFGLMGAAFGIGFTFGPALGGWLWEFDHRAPFLVCA 346
>UniRef50_A6H1H8 Cluster: Major facilitator superfamily (MFS)
permease; n=1; Flavobacterium psychrophilum
JIP02/86|Rep: Major facilitator superfamily (MFS)
permease - Flavobacterium psychrophilum (strain JIP02/86
/ ATCC 49511)
Length = 411
Score = 52.0 bits (119), Expect = 3e-05
Identities = 42/165 (25%), Positives = 68/165 (41%), Gaps = 6/165 (3%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHI-----YVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D GLI P++P + + + I Y G L YA Q P++G+LSD GR
Sbjct: 17 VIDTAGFGLIFPVLPQLLINLLHSDISTAAKYGGWLSFAYAIMQFVFAPVLGNLSDQYGR 76
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R S+ L + +A A V D ++ +
Sbjct: 77 RPVLLSSLFGFSIDCIFLAFAPSILWLFVGRTIAGITGASYSVASACVADISTDDNRTKN 136
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIF 160
+G + A G+G +GP+IGG + + + F+ A + I FIF
Sbjct: 137 -FGLINAGFGLGFIIGPIIGGTLGQFGTHTPFIVAAILSFINFIF 180
>UniRef50_A2SG94 Cluster: Tetracycline-efflux transporter; n=2;
Proteobacteria|Rep: Tetracycline-efflux transporter -
Methylibium petroleiphilum (strain PM1)
Length = 418
Score = 52.0 bits (119), Expect = 3e-05
Identities = 35/140 (25%), Positives = 64/140 (45%), Gaps = 5/140 (3%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANH----IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
++D++++GLIIP++P V + + G++ +A P++G+LSD GRR
Sbjct: 20 LIDMVSIGLIIPVLPLLVGSFTGSPSDTAFWFGVVTFAFAIANFFGSPILGALSDRYGRR 79
Query: 57 XXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
++ + L+ + +A A V D EQ+ A
Sbjct: 80 PVLLIGFCGLALNFFFTALSTALWMLVAVRLVGGAMQANAAVANAYVADITPPEQR-ARR 138
Query: 117 YGKMAAISGVGITLGPMIGG 136
+G + A+ G+G LGP++GG
Sbjct: 139 FGLLGAMFGLGFILGPVLGG 158
>UniRef50_A3WCL4 Cluster: Permease; n=1; Erythrobacter sp. NAP1|Rep:
Permease - Erythrobacter sp. NAP1
Length = 416
Score = 51.6 bits (118), Expect = 4e-05
Identities = 35/140 (25%), Positives = 57/140 (40%), Gaps = 6/140 (4%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHI-----YVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
+D++ +GLI+P++PG + ++ + G L YA Q P+IG LSD GRR
Sbjct: 24 IDMVGIGLIVPVLPGLLEEVTGETLDQTAQIGGWLLFAYAVMQFTFAPIIGGLSDRFGRR 83
Query: 57 XXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
V Y ++ + A + + D E++ +
Sbjct: 84 PVLLFTLFMLGVDYAIMAWAPTLFWLFVGRILSGIMGASWAAANSAIADVAEPEER-GKF 142
Query: 117 YGKMAAISGVGITLGPMIGG 136
+G M A G +GP IGG
Sbjct: 143 FGIMGAAGAAGFVIGPGIGG 162
>UniRef50_Q9I4K4 Cluster: Probable major facilitator superfamily
(MFS) transporter; n=5; Pseudomonas aeruginosa|Rep:
Probable major facilitator superfamily (MFS) transporter
- Pseudomonas aeruginosa
Length = 422
Score = 51.2 bits (117), Expect = 5e-05
Identities = 80/363 (22%), Positives = 144/363 (39%), Gaps = 27/363 (7%)
Query: 1 MVDLLAVGLIIPLVP---GHVRKMGANHI--YVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
++D VGLI+PL+P G V + + L +A QL P++GSLSD GR
Sbjct: 30 LLDAAGVGLIVPLLPTLIGSVAPLAVRDAATWGAALVMTFALLQLFFSPVLGSLSDRFGR 89
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
R +++Y +L L + A A D + Q+
Sbjct: 90 RPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTRH 149
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXX 175
+G + A +G+ LGP +GG + +G + + G+C + NA L
Sbjct: 150 -FGWLYAGLALGMILGPALGGLLA---VHGTTLPLLLAAGLC-LLNALLA---GLFLEET 201
Query: 176 XXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNY 235
D N + S+ +Q V + ALV + +
Sbjct: 202 LPPTRRRRLDPRRMNALRSISGLARQPGV----------GRLLAVLALVFLGLQAVMVVW 251
Query: 236 ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSIS 295
++ + S ++GY ++ GV+ ++ + +G +N ++ D L L + L
Sbjct: 252 PFFVIEKFHWSSAWIGYSLALYGVL-AVLAQTLG-VNLCKRRLDDARLLRLGLALQGCGL 309
Query: 296 LTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGV 355
L +V + + V L+P A+G+ + + ++ R D +G L G +S+ SL+ +
Sbjct: 310 LLFALVDSSFW-LVCALLPFALGSLATPAMQ-GLLSARVPVDRQGELQGVLSSLMSLAAI 367
Query: 356 VAP 358
V P
Sbjct: 368 VGP 370
>UniRef50_Q62C01 Cluster: Multidrug resistance protein; n=16;
Proteobacteria|Rep: Multidrug resistance protein -
Burkholderia mallei (Pseudomonas mallei)
Length = 429
Score = 51.2 bits (117), Expect = 5e-05
Identities = 40/171 (23%), Positives = 72/171 (42%), Gaps = 8/171 (4%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVG-LLGSIYAGF---QLGSGPLIGSLSDLKGRRX 57
VD + +G+ P++P +R +G +V +LGS+ F Q GP++G+LSD GRR
Sbjct: 38 VDAVGLGVATPVLPDLLRAVGERPAHVPVMLGSLITCFYFMQFVFGPIVGALSDAWGRRP 97
Query: 58 XXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIY 117
+++Y + + +A A + D +A +
Sbjct: 98 ILLIALGGGALSYAIGATARSYGGLLAAHMLAGIAASSAAVATAYLADV-TPPALRARRF 156
Query: 118 GKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFL 168
+++ G+G+ GP GG + P F+ I + F+ + CFL
Sbjct: 157 ALASSVLGLGLIAGPAFGGVLGALGPRVPFVAAGAIAALNFV---SAACFL 204
>UniRef50_Q1IVW2 Cluster: Major facilitator superfamily MFS_1; n=1;
Deinococcus geothermalis DSM 11300|Rep: Major
facilitator superfamily MFS_1 - Deinococcus geothermalis
(strain DSM 11300)
Length = 411
Score = 51.2 bits (117), Expect = 5e-05
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 5/136 (3%)
Query: 5 LAVGLIIPLVP----GHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
L + L+ P++P +V + G +G LG+ YA + P++G+LSD GRR
Sbjct: 27 LGLSLVFPVLPYIVMQYVPEAGRQAAVLGWLGASYALLSFFAAPVLGALSDAYGRRPVLM 86
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
+V Y + G+ + D E+ + ++G++
Sbjct: 87 LSLLGSAVGYVIFGIGGSLVMLFLGRSIDGLTAGGMSALFGYLAD-TTPEEDRGRVFGQV 145
Query: 121 AAISGVGITLGPMIGG 136
A G G +GP +GG
Sbjct: 146 GATVGAGFIIGPAVGG 161
>UniRef50_A4AC28 Cluster: Tetracycline-efflux transporter; n=1;
Congregibacter litoralis KT71|Rep: Tetracycline-efflux
transporter - Congregibacter litoralis KT71
Length = 389
Score = 51.2 bits (117), Expect = 5e-05
Identities = 35/142 (24%), Positives = 64/142 (45%), Gaps = 3/142 (2%)
Query: 7 VGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXC 66
+G++IP++P ++GA+ + ++ + YA +GP G LSD GR+
Sbjct: 12 LGIVIPILPFLSPRLGASDFDIAMIIASYAVCAGVAGPWWGKLSDHIGRKPVLMICTTGA 71
Query: 67 SVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGV 126
++AY +L +A A++ D +A G + A G+
Sbjct: 72 ALAYVLLASAQSLTMIFVARAFAGLMAGNFGVASAMMADI-TPPADRARGMGMIGASFGL 130
Query: 127 GITLGPMIGGHIMEDNPNGAFM 148
G+ LGP++GG + P G+F+
Sbjct: 131 GLVLGPVLGG--LLSGPEGSFV 150
>UniRef50_Q8NM37 Cluster: Permeases of the major facilitator
superfamily; n=3; Corynebacterium|Rep: Permeases of the
major facilitator superfamily - Corynebacterium
glutamicum (Brevibacterium flavum)
Length = 398
Score = 50.8 bits (116), Expect = 6e-05
Identities = 39/134 (29%), Positives = 55/134 (41%), Gaps = 4/134 (2%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGL-LGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
LA + +P +PG +G V L L S AG +G +IG LSD GR+
Sbjct: 24 LATDMYLPAMPGIAEDLGTTAPMVQLTLSSFMAGMAIGQ-LIIGPLSDQLGRKGLLVAGA 82
Query: 64 XXCSVAYTVLGLT-XXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAA 122
VA V L ++A+A+VPD E QK A + +
Sbjct: 83 VAALVASVVCALAPSISVLVIARLVQGLGGGACVVIARAIVPDLERG-QKAAHAFALLMI 141
Query: 123 ISGVGITLGPMIGG 136
I G+ + P+IGG
Sbjct: 142 IQGIAPVVAPLIGG 155
>UniRef50_P39843 Cluster: Multidrug resistance protein 2; n=18;
Firmicutes|Rep: Multidrug resistance protein 2 -
Bacillus subtilis
Length = 400
Score = 50.8 bits (116), Expect = 6e-05
Identities = 72/398 (18%), Positives = 148/398 (37%), Gaps = 29/398 (7%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
V L +GLIIP++P ++ M + +G L + +A QL + P G D GR+
Sbjct: 21 VAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIIL 80
Query: 62 XXXXCSVAYTVLGL-TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
S++ + GL T A V D +++ ++ G +
Sbjct: 81 GLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIMPAVTAYVADITTLKER-SKAMGYV 139
Query: 121 AAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXX 180
+A G +GP GG I F F + I AL+ +
Sbjct: 140 SAAISTGFIIGPGAGGFIAGFGIRMPFFFASAI---------ALIAAVTSVFILKESLSI 190
Query: 181 XXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
+ S + K+S +Y I F+ ++ F + Y + ++L+
Sbjct: 191 EERHQLSSHTKESNFIKDLKRSIHPVYFI-------AFIIVFVMAFGLSAYETVFSLFSD 243
Query: 241 TTYDLSPKYVGYVISFQGVMGSISS--YFIGYINSF-YKKDVDYSLRSLHVFLLLSISLT 297
+ +PK + +I+ ++ + F +N K+ + L + + +S ++
Sbjct: 244 HKFGFTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEKRMIQLCLITGAILAFVSTVMS 303
Query: 298 GLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVA 357
G + + V ++ L + L + G+ +G + G +++ SL +
Sbjct: 304 GFLTVLLVTCFIFLAFDLLRPALTAHLSNMA-------GNQQGFVAGMNSTYTSLGNIFG 356
Query: 358 PMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTKR 395
P + G L + Y + ++GL ++ ++ K+
Sbjct: 357 PALGGILFD-LNIHYPFLFAGFVMIVGLGLTMVWKEKK 393
>UniRef50_Q75TC8 Cluster: Multidrug-efflux transporter; n=3;
Geobacillus|Rep: Multidrug-efflux transporter -
Geobacillus kaustophilus
Length = 394
Score = 50.4 bits (115), Expect = 8e-05
Identities = 35/130 (26%), Positives = 58/130 (44%), Gaps = 2/130 (1%)
Query: 8 GLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCS 67
G+IIP++P + +GA +G L ++Y+ Q P+ G+LSD GR+ +
Sbjct: 27 GIIIPVLPFYAETIGATPTQLGWLMAVYSLMQFLFAPMWGNLSDRYGRKPMLLVGIFGLA 86
Query: 68 VAYTVLGL-TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGV 126
+++ +L + T T A A V D E+ + + G + A G+
Sbjct: 87 LSFFLLAVATKLWMLFAARIIGGCLSAATMPAAMAYVADV-TTEEDRGKGMGMIGAAVGL 145
Query: 127 GITLGPMIGG 136
G GP IGG
Sbjct: 146 GFIFGPGIGG 155
Score = 37.1 bits (82), Expect = 0.81
Identities = 31/150 (20%), Positives = 68/150 (45%), Gaps = 10/150 (6%)
Query: 217 IFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYK 276
++L + + F++ + +A + LS +GY+ G+ G+I G + +
Sbjct: 214 LYLLQLITTFSLAGLEATFAYFAAERAGLSSTELGYIFMIMGLAGAIVQG--GLLGKLIR 271
Query: 277 KDVDYSLRSLHVFLLLSISLTGLIVSINVYNY---VIWLIPLAMGNAVSRLVTLEMVLKR 333
+ ++ + +FL S G + + V+++ ++L +GN V R + +L +
Sbjct: 272 SFGEGAVIRVGLFL----SAVGFFLILFVHSFWTAALYLTIFGIGNGVIR-PCVSALLTK 326
Query: 334 SDGDHRGTLIGASNSVRSLSGVVAPMVAGF 363
D +G+ G +S SL + P +AG+
Sbjct: 327 YTADGQGSATGVLSSFDSLGRIGGPAIAGW 356
>UniRef50_A3H8C5 Cluster: Major facilitator superfamily MFS_1; n=1;
Caldivirga maquilingensis IC-167|Rep: Major facilitator
superfamily MFS_1 - Caldivirga maquilingensis IC-167
Length = 391
Score = 50.0 bits (114), Expect = 1e-04
Identities = 27/104 (25%), Positives = 59/104 (56%), Gaps = 2/104 (1%)
Query: 270 YINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEM 329
YI+ +DV Y+ SL + +L + L + +S N+Y Y I L L + + ++ ++L +
Sbjct: 253 YISVRPIRDVKYA--SLSMSMLTIVGLVIMTISPNIYLYAISLAILGVPHGLTYPLSLIV 310
Query: 330 VLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYV 373
+ + S D R + A +S+ ++ G+++P+ G + + +G+ Y+
Sbjct: 311 ISRDSKDDERNLMNSAFSSIMTIIGILSPIALGVSAELMGLRYM 354
>UniRef50_Q192M5 Cluster: Major facilitator superfamily MFS_1; n=2;
Desulfitobacterium hafniense|Rep: Major facilitator
superfamily MFS_1 - Desulfitobacterium hafniense (strain
DCB-2)
Length = 392
Score = 49.2 bits (112), Expect = 2e-04
Identities = 31/136 (22%), Positives = 54/136 (39%), Gaps = 2/136 (1%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
++ G++IP++P + ++G +GL S Y+ Q P G LSD GRR
Sbjct: 20 MVGFGIVIPILPFLIEELGGGAFSLGLFMSAYSIMQFFFAPFWGRLSDRIGRRPVLLIGL 79
Query: 64 XXCSVAYTVLGLTXXX-XXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAA 122
+ + + G+ T A A + D + + G + A
Sbjct: 80 SGYGITFFLYGMAGNLPLLIAFRALSGVVSSATLPTAMAYMADITEGADRSKSM-GMLGA 138
Query: 123 ISGVGITLGPMIGGHI 138
G+G+ GP +GG +
Sbjct: 139 AMGLGMVFGPALGGFL 154
Score = 42.3 bits (95), Expect = 0.022
Identities = 34/162 (20%), Positives = 70/162 (43%), Gaps = 5/162 (3%)
Query: 217 IFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYK 276
+F++ ++ F M ++ S + L+ P+ +G V G+ G I + I +
Sbjct: 210 LFIFNFVLSFTMAMFESTFTLFAAERVGFGPQEMGIVFMIIGITGVIVQGML--IGKVVR 267
Query: 277 KDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDG 336
+ D + LL +++ L+ + N V+ + +GN+ + T ++ ++
Sbjct: 268 RFGDAKPAKVGA-LLCAVAFLWLLWAPNAILLVLGTVVFMIGNSF-MVPTGSSLVSKNSH 325
Query: 337 DHRGTLIGASNSVRSLSGVVAPMV-AGFTGQFLGVSYVIYAS 377
+G +G S SL + P+V G G + YVI A+
Sbjct: 326 TGQGASLGVFQSFGSLGRIAGPLVGGGIYGLSMNTPYVIGAA 367
>UniRef50_Q9UYY0 Cluster: Multidrug resistance protein; n=4;
Thermococcaceae|Rep: Multidrug resistance protein -
Pyrococcus abyssi
Length = 410
Score = 49.2 bits (112), Expect = 2e-04
Identities = 32/168 (19%), Positives = 78/168 (46%), Gaps = 8/168 (4%)
Query: 223 LVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYS 282
L A G Y+ ++Y + + ++VGY+ + ++S+ IG + Y + + +
Sbjct: 248 LAMIASGAVYATVSVYFEEKF--GEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFR 305
Query: 283 LRSL-HVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGT 341
L + ++ + +L ++ + + + + L + N+ S V +R RG
Sbjct: 306 LSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVA-----RRVPTSERGQ 360
Query: 342 LIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSY 389
+G N++ +L V+ P++ G G + ++Y+++ LG ++S+
Sbjct: 361 GMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSF 408
>UniRef50_Q12ZN0 Cluster: Major facilitator superfamily (MFS)
transporter; n=1; Methanococcoides burtonii DSM
6242|Rep: Major facilitator superfamily (MFS)
transporter - Methanococcoides burtonii (strain DSM
6242)
Length = 343
Score = 49.2 bits (112), Expect = 2e-04
Identities = 21/55 (38%), Positives = 33/55 (60%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
+D L G++IP + V + G N I G +G++Y FQL P++G SD+ GR+
Sbjct: 22 IDALGFGIVIPFLVFLVDQFGGNAIVYGFIGAMYPAFQLIGAPILGRWSDIHGRK 76
>UniRef50_A3I9G6 Cluster: Multidrug-efflux transporter; n=1;
Bacillus sp. B14905|Rep: Multidrug-efflux transporter -
Bacillus sp. B14905
Length = 392
Score = 48.8 bits (111), Expect = 2e-04
Identities = 35/158 (22%), Positives = 67/158 (42%), Gaps = 3/158 (1%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
L G+IIP++P + + ++++VG L ++Y+ + P G LSD GR+
Sbjct: 23 LGFGIIIPVLPEVIVQQNWDNLHVGGLLTVYSLASFFTAPFWGMLSDKVGRKQLILTGLI 82
Query: 65 XCSVAYTVLGL--TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAA 122
S+++ + L + D ++E+ + + G M
Sbjct: 83 GFSLSFVIFSLFIDNLAILYVSRVVGGLFSGALYTAVTGFIADM-SSEETRNKYMGFMGM 141
Query: 123 ISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIF 160
G+G GP IGG + + F+ A ++G+ FI+
Sbjct: 142 SIGLGFIFGPAIGGMLGHYSLQLPFIASAILIGLLFIY 179
Score = 44.4 bits (100), Expect = 0.005
Identities = 38/182 (20%), Positives = 82/182 (45%), Gaps = 10/182 (5%)
Query: 217 IFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQG-VMGSISSYFIGYINSFY 275
+F++ LV F + + + L+ ++P +GY+ F G V +I + I
Sbjct: 214 LFMFSFLVTFMLAGVEATFQLFQIEKIQITPLQIGYLFMFSGFVDAAIQGGVVRRI---- 269
Query: 276 KKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSD 335
K+ + + ++ ++ + ++ N++ + L GNA++R + + K S
Sbjct: 270 -KNGSETTWLIGAQIVTAVGMLLFTLTANLFIAGLALCVFTAGNALARTCVVSLSSKESG 328
Query: 336 GDHRGTLIGASNSVRSLSGVVAPMVAGFTGQF-LGVSYVIYASLAPTVLGLVMSYHYRTK 394
G + GT G S S+ +L ++ P+ FT F + S Y S +L + + + ++
Sbjct: 329 GQY-GTAAGLSYSMDNLGRILGPLF--FTWLFTMHASLGYYTSAVIAILSISLIFIFKAS 385
Query: 395 RK 396
+K
Sbjct: 386 KK 387
>UniRef50_A3ZND9 Cluster: Multidrug resistance protein; n=1;
Blastopirellula marina DSM 3645|Rep: Multidrug
resistance protein - Blastopirellula marina DSM 3645
Length = 433
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/139 (25%), Positives = 59/139 (42%), Gaps = 6/139 (4%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANH--IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXX 59
+DLL G+++PL+P + + G + I +GLL + ++ Q PL G LSD GRR
Sbjct: 26 IDLLGFGIVLPLLPIYAAQFGVDEHGIELGLLMASFSAMQFLFAPLWGLLSDRIGRRPVI 85
Query: 60 XXXXXXCSVAYTVLGLTXX---XXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
+ Y + G+ T A+A + D + E + +
Sbjct: 86 MIGLSGSVIFYAIFGIATEWQCIWLLFVARIGAGIAGATISTAQAYIADTTSLENRSKGM 145
Query: 117 YGKMAAISGVGITLGPMIG 135
+ G+G T GP++G
Sbjct: 146 -ALIGMAFGLGFTFGPLLG 163
>UniRef50_A3HS41 Cluster: Major facilitator superfamily (MFS_1)
transporter; n=1; Algoriphagus sp. PR1|Rep: Major
facilitator superfamily (MFS_1) transporter -
Algoriphagus sp. PR1
Length = 407
Score = 48.4 bits (110), Expect = 3e-04
Identities = 44/184 (23%), Positives = 90/184 (48%), Gaps = 12/184 (6%)
Query: 210 NWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPK--YVGYVISFQGVMGSISSYF 267
NW ++ + + ALVG +G+ S + Y + LS ++ ++ +F G +I++Y
Sbjct: 11 NWKQFLILVIVNALVGSMLGMERSIFPQYASEIFGLSSNFAFLSFITAF-GFSKAITNYL 69
Query: 268 IG-YINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWL-IPLAMGNAVSRLV 325
G + N+F +K + L + +L+I + L++ + +NYVI + L + ++
Sbjct: 70 TGKFANNFGRK------KLLILGWILAIPVPILLIFASNWNYVILANVLLGVSQGLTWGS 123
Query: 326 TLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYV-IYASLAPTVLG 384
T+ M + RG +G + LS V+ ++ + + GVS Y + ++LG
Sbjct: 124 TVIMKIDLVGEKDRGFAMGMNEFAGYLSLGVSAYLSAYLAEKFGVSPTPFYIGVVVSILG 183
Query: 385 LVMS 388
L++S
Sbjct: 184 LLLS 187
>UniRef50_UPI0000D9D6E6 Cluster: PREDICTED: similar to tumor
suppressing subtransferable candidate 5; n=1; Macaca
mulatta|Rep: PREDICTED: similar to tumor suppressing
subtransferable candidate 5 - Macaca mulatta
Length = 316
Score = 47.2 bits (107), Expect = 8e-04
Identities = 32/142 (22%), Positives = 58/142 (40%), Gaps = 5/142 (3%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
++L + + +VP RK+G + I G L + + QL GP+ G +D +G R
Sbjct: 35 IELTCLFMQFSVVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTL 94
Query: 62 XXXXCSVAYTVLGLTXX----XXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIY 117
Y +L T A+ ++ D E++ A +
Sbjct: 95 SFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAAL- 153
Query: 118 GKMAAISGVGITLGPMIGGHIM 139
G++ GVG+ LG ++GG ++
Sbjct: 154 GRLGLCFGVGVILGSLLGGTLV 175
>UniRef50_Q0W0C7 Cluster: Putative permease; n=1; uncultured
methanogenic archaeon RC-I|Rep: Putative permease -
Uncultured methanogenic archaeon RC-I
Length = 435
Score = 47.2 bits (107), Expect = 8e-04
Identities = 23/72 (31%), Positives = 40/72 (55%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
L G+IIP++P + +GA + +GLL + ++ Q P+ G++SD GR+
Sbjct: 22 LGFGVIIPVMPYYANNLGATALDLGLLMATFSAMQFVCAPVWGAISDRIGRKPVMMIGLT 81
Query: 65 XCSVAYTVLGLT 76
+A+TV GL+
Sbjct: 82 GFGLAFTVTGLS 93
>UniRef50_UPI00015B5592 Cluster: PREDICTED: similar to GA19110-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
GA19110-PA - Nasonia vitripennis
Length = 451
Score = 46.4 bits (105), Expect = 0.001
Identities = 28/110 (25%), Positives = 47/110 (42%), Gaps = 1/110 (0%)
Query: 26 IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXX 85
++ G LGS+Y+ Q P+IG+LSD+ GR+ +++Y + L+
Sbjct: 85 LFGGFLGSLYSFLQFLGSPIIGALSDVYGRKPLMILCLTGIALSYLLWALSSNFGLFILA 144
Query: 86 XXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIG 135
K L+ A++ D + + + VG LGPMIG
Sbjct: 145 RVLGGISKGNVNLSMAIISDV-TSPASRGRAMALVGIAFSVGFVLGPMIG 193
>UniRef50_Q88YJ0 Cluster: Multidrug transport protein; n=5;
Lactobacillaceae|Rep: Multidrug transport protein -
Lactobacillus plantarum
Length = 398
Score = 46.4 bits (105), Expect = 0.001
Identities = 33/133 (24%), Positives = 57/133 (42%), Gaps = 2/133 (1%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
L + L+IP++P ++ +G++ +++A Q + P+IG +SD GR+
Sbjct: 21 LGISLVIPVMPFIKNELHLTATDMGIMNALFALAQFVASPIIGRVSDKVGRKPVLTVGLV 80
Query: 65 XCSVAYTVLGLTXXX-XXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAI 123
V+ + LT A AL D Q+ A++ G ++A
Sbjct: 81 LYMVSEVLFALTNQLWVFNISRIVGGLSAAMVVPTAMALASDITTKRQR-AKVIGWLSAA 139
Query: 124 SGVGITLGPMIGG 136
G+ LGP IGG
Sbjct: 140 FSGGLILGPGIGG 152
>UniRef50_A3I7Q7 Cluster: Multidrug-efflux transporter; n=2;
Bacillus|Rep: Multidrug-efflux transporter - Bacillus
sp. B14905
Length = 395
Score = 46.4 bits (105), Expect = 0.001
Identities = 35/152 (23%), Positives = 70/152 (46%), Gaps = 5/152 (3%)
Query: 252 YVISFQGVMGSISSYF--IGYINSFYKKDVDYSLRSLHVF---LLLSISLTGLIVSINVY 306
+ +S V ++SS+ I I VD+ + +F LL+ +S + +
Sbjct: 41 FEVSISWVNFTVSSFIFIIAVIQIVLGTVVDHQNKKRLLFISLLLMGVSAVFCAYTNSFM 100
Query: 307 NYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQ 366
+ ++ + A+G + LV + M+ + +G+ RG+ +G + +L+ V+P+V GF G+
Sbjct: 101 LFTLFRMIQAIGAGIIPLVAISMIAQLFEGEARGSAMGTYQILLTLAPAVSPVVGGFIGE 160
Query: 367 FLGVSYVIYASLAPTVLGLVMSYHYRTKRKVD 398
F G + L V L++ + K D
Sbjct: 161 FFGYEGIFLFLLIMAVSLLMLIVYLLPSEKQD 192
>UniRef50_A3CSK5 Cluster: Major facilitator superfamily MFS_1
precursor; n=1; Methanoculleus marisnigri JR1|Rep: Major
facilitator superfamily MFS_1 precursor - Methanoculleus
marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Length = 397
Score = 46.4 bits (105), Expect = 0.001
Identities = 31/138 (22%), Positives = 63/138 (45%), Gaps = 6/138 (4%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR---XXXX 60
+L +G++ PL+P + +GA I++G++ S +A + P+IG +SD +GR+
Sbjct: 19 MLGLGIVSPLLPIYAENLGATGIWLGIIFSAFALSRSVFMPVIGRISDRRGRKWIILIGM 78
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
S+AY + + +A A V D + + ++ G
Sbjct: 79 FAYAVLSLAYII--VDSVYSLTAVRFAHGLASAMVVPIAMAYVADL-SEKGREGSHMGNF 135
Query: 121 AAISGVGITLGPMIGGHI 138
+ +G+ +GP++GG +
Sbjct: 136 SISMFLGMGMGPLLGGFL 153
Score = 36.7 bits (81), Expect = 1.1
Identities = 17/70 (24%), Positives = 36/70 (51%)
Query: 315 LAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVI 374
+ +G A+ + + + + GT +GA N+V + ++AP++ G ++G+ V
Sbjct: 304 VGIGGAIQQPAIMALTVDAGRTIGMGTSMGAYNTVFGIGMIIAPLMGGVFMDYIGIDAVF 363
Query: 375 YASLAPTVLG 384
Y A ++LG
Sbjct: 364 YVGGAISLLG 373
>UniRef50_Q18R58 Cluster: Major facilitator superfamily MFS_1
precursor; n=2; Desulfitobacterium hafniense|Rep: Major
facilitator superfamily MFS_1 precursor -
Desulfitobacterium hafniense (strain DCB-2)
Length = 388
Score = 46.0 bits (104), Expect = 0.002
Identities = 32/134 (23%), Positives = 62/134 (46%), Gaps = 4/134 (2%)
Query: 259 VMGSISSYFIGYINSFYKKDVDY-SLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAM 317
++ + S FI + Y K Y ++L F L L G + + + +I + +
Sbjct: 44 LISGLPSLFIVFFAPIYGKLTQYFPKKALLAFASLCFVLGGFLPAFMTHFTLILAMRCLL 103
Query: 318 GNAVSRLVTL--EMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIY 375
G + L+ + +++ DG R T++G ++ S+ G++ M GF G F G +Y Y
Sbjct: 104 GVGLGFLMPMAADLISDFFDGHERQTMMGFQSAFTSIGGIMYQMAGGFLGSF-GWNYAFY 162
Query: 376 ASLAPTVLGLVMSY 389
A L ++ L + +
Sbjct: 163 AYLLGVIIFLAVHF 176
>UniRef50_A1I922 Cluster: Major facilitator superfamily MFS_1
precursor; n=1; Candidatus Desulfococcus oleovorans
Hxd3|Rep: Major facilitator superfamily MFS_1 precursor
- Candidatus Desulfococcus oleovorans Hxd3
Length = 410
Score = 46.0 bits (104), Expect = 0.002
Identities = 19/53 (35%), Positives = 36/53 (67%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
++ VG+++PL+P + + +GA+ Y+GL+ + ++ + PL GSLSD GR+
Sbjct: 23 VMGVGIVVPLLPVYAQNLGASGFYIGLIFAAFSLSRTFLLPLFGSLSDRTGRK 75
>UniRef50_Q14728 Cluster: Tetracycline transporter-like protein;
n=23; Euteleostomi|Rep: Tetracycline transporter-like
protein - Homo sapiens (Human)
Length = 455
Score = 45.6 bits (103), Expect = 0.002
Identities = 36/144 (25%), Positives = 59/144 (40%), Gaps = 2/144 (1%)
Query: 18 VRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTX 77
V K + ++ GL+GS ++ Q PL G+ SD GRR + +Y V +
Sbjct: 79 VEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSR 138
Query: 78 XXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGH 137
K L+ A+V D + +++ + +G TLGPM+G
Sbjct: 139 SFAAFLASRLIGGISKGNVSLSTAIVADL-GSPLARSQGMAVIGVAFSLGFTLGPMLGAS 197
Query: 138 I-MEDNPNGAFMFIAFIVGICFIF 160
+ +E P A +F A + F F
Sbjct: 198 LPLEMAPWFALLFAASDLLFIFCF 221
>UniRef50_Q7NRP4 Cluster: Probable multidrug resistance protein;
n=1; Chromobacterium violaceum|Rep: Probable multidrug
resistance protein - Chromobacterium violaceum
Length = 407
Score = 44.8 bits (101), Expect = 0.004
Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 5/148 (3%)
Query: 223 LVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYS 282
L+ A Y AL+L+ Y L P++VGY+ + G+M + + I + + S
Sbjct: 231 LITLAFDQMYVTLALFLREHYQLGPQWVGYLFTLNGLM--VVALQIPISRRILRWGLARS 288
Query: 283 LRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTL 342
+ L V LL S L V V+ ++ L G + +V+ RS+G RG+
Sbjct: 289 TQ-LGV-LLTGCSFLWLNAGHGVPWAVLMMMTLTFGELLLSPSYAHLVMHRSEGRLRGSY 346
Query: 343 IGASNSVRSLSGVVAPMV-AGFTGQFLG 369
+G N+ + +VAP + GQF G
Sbjct: 347 LGLYNAAWNGRTLVAPALGTALYGQFGG 374
>UniRef50_Q9V395 Cluster: CG5760-PA; n=5; Endopterygota|Rep:
CG5760-PA - Drosophila melanogaster (Fruit fly)
Length = 477
Score = 44.8 bits (101), Expect = 0.004
Identities = 67/347 (19%), Positives = 132/347 (38%), Gaps = 25/347 (7%)
Query: 26 IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXX 85
++ G LGS+++ Q + P++G LSD GR+ +++Y + +
Sbjct: 111 LFGGFLGSMFSFLQFVASPIVGGLSDYYGRKPVLLACASGIALSYLIWACSSNFALFVLA 170
Query: 86 XXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGG--HIMEDNP 143
K L +++ D + + + + A S +G +GPMIG I D
Sbjct: 171 RFVGGISKGNISLCMSVITDVSSVKTRGRGMALVGVAFS-LGFIVGPMIGALFAIFSDKS 229
Query: 144 NGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNSF---- 199
+ + ++ +V LS L L F++
Sbjct: 230 GSTWFVLPSLLAFGLAVGDLVVLACCLRETLPKEKRVKEISSALSYGLQLLNFSAIFRFA 289
Query: 200 ------KQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYV 253
K+ L SI + +FLY G V + Y + T+ D + ++
Sbjct: 290 AIKNVPKKDIAALRSIGLVYFLYLFLYS---GLEFTVTFLMYHKFGYTSMDQAKMFLTTG 346
Query: 254 ISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLI 313
+ + GS+ K Y++ SL++ ++ + + GL + + L
Sbjct: 347 VIMTLLQGSVVRRLP------EAKIKGYAIFSLYL-IVPAFVVVGLAEGSRMLYAGMTLF 399
Query: 314 PLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMV 360
++ AV+ L TL V K + D +G+++G S+ +L+ + P+V
Sbjct: 400 AISTAFAVTCLTTL--VSKYGNDDQKGSVLGIFRSLGALARALGPVV 444
>UniRef50_Q83CB9 Cluster: Multidrug transporter, putative; n=5;
Coxiella burnetii|Rep: Multidrug transporter, putative -
Coxiella burnetii
Length = 412
Score = 44.4 bits (100), Expect = 0.005
Identities = 56/304 (18%), Positives = 133/304 (43%), Gaps = 25/304 (8%)
Query: 95 TQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIV 154
+Q +A+A V D + + K + G + +G+ GP+IGG + + + ++ +
Sbjct: 126 SQPIAQAAVVDI-SPKNKLSRYLGYVIMAVSIGLIAGPLIGGFLSDHD------YVRWFS 178
Query: 155 GICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKY 214
++ AAL+ F+ + E L L + + FV + ++
Sbjct: 179 YSTPLYFAALLAFV----NILLLIIYFKETGITKEKTQLKLTRAL-EIFVSAFRHPSVRF 233
Query: 215 WDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSF 274
I +G++ +YY + ++ ++LS + V + +F GV ++ + +
Sbjct: 234 LSICYLLLQIGWS--IYYIYISAFIVQKFNLSLRGVSILFAFVGVG---LTFGLAVLPGI 288
Query: 275 YKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIW----LIPLAMGNAVSRLVTLEMV 330
++K +++ + + +F SI GLI ++ N IW + PL G A++ + +
Sbjct: 289 FEKQ-NFNRKHVTIF-GYSILFLGLIFTV-FPNKAIWPWIMIFPLTCGLALAYSFLISLY 345
Query: 331 LKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYH 390
+ +G ++G ++++ +L +A + L V++ YA++ +G+ +
Sbjct: 346 SNEVGPEKQGWIMGITSAIVALGAAIASFLEAVLST-LNVNFPYYAAIVLIAIGISLMTR 404
Query: 391 YRTK 394
++ K
Sbjct: 405 FKPK 408
>UniRef50_Q1PJF6 Cluster: Multidrug efflux transporter, MFS family;
n=7; Prochlorococcus marinus|Rep: Multidrug efflux
transporter, MFS family - uncultured Prochlorococcus
marinus clone HOT0M-3E5
Length = 427
Score = 44.4 bits (100), Expect = 0.005
Identities = 75/371 (20%), Positives = 134/371 (36%), Gaps = 26/371 (7%)
Query: 3 DLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXX 62
D L+ +++P++P V + GLL Y Q + P IG +SD GRR
Sbjct: 29 DRLSESILLPILPSFVLLFDSKASTYGLLSCTYQLAQFTASPFIGLMSDRYGRRPVTLFC 88
Query: 63 XXXCSVAYTVLGLTXXXXXXXXXXX-----------XXXXXKQTQMLAKALVPDYENNEQ 111
+ ++L T T A ++ D + E
Sbjct: 89 ITGSVIGISILSFTVLFNWSNSIATIPLFLLFLARLIDGLSGGTAATATTILADISSPE- 147
Query: 112 KQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXX 171
K+A+ +G + G+ LG I I N N F+ I I I N LV F
Sbjct: 148 KRAKTFGLIGVAFGLSFFLG-NIFVVIFARNTNNNFIIPVLIASIIPIINFLLVFFYLPE 206
Query: 172 XXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVY 231
+N + +LF FK+ + S+ + Y+ + L ++
Sbjct: 207 TKPNSEINKSKTA---LKNPLKALFTVFKEEKIKKLSLAFFIYF--IAFTGLTNIL--IF 259
Query: 232 YSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLL 291
+ +L T V +I+ V G + + + + LL
Sbjct: 260 FLQESLNWTTKASSGTLVVVGIIAII-VQGGLIGPLVKQFGEMRLTLIGSGFILVACALL 318
Query: 292 LSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRS 351
++ +IN+Y+ V + LA+G + ++ K+ D D +G+++ ++S
Sbjct: 319 ITAPKEN--ATINIYSAVSF---LAVGAGLITPTLRALISKKLDVDKQGSILSNLQGLQS 373
Query: 352 LSGVVAPMVAG 362
L GV+ +AG
Sbjct: 374 LGGVLGIAMAG 384
>UniRef50_Q19296 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 445
Score = 44.4 bits (100), Expect = 0.005
Identities = 75/363 (20%), Positives = 139/363 (38%), Gaps = 30/363 (8%)
Query: 29 GLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXX 88
G LGS+++ Q S P +GSLSD+ GRR ++Y
Sbjct: 80 GFLGSLFSALQFISSPTLGSLSDIYGRRAVISLCCIMTFISYVNWLKADIFAYFVLSRIL 139
Query: 89 XXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAIS-GVGITLGPMIGGHIME----DNP 143
K +A A+V D + E + + IS +G +GPMIG + D+P
Sbjct: 140 GGLSKGNINVATAIVSDVYSPEDHPKGM--ALIGISYSLGFLIGPMIGAYFSTIASIDSP 197
Query: 144 ---NGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNSFK 200
F I I+ F+F L + + N+ +
Sbjct: 198 FAYPAMFSIILTILEFGFLFFLPETLDLKEQKSLDDIKKTRKELVTPKDLFQFTAVNAPQ 257
Query: 201 QSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQG-V 259
+ + + W + +FLY L + + +++ +D G V F G +
Sbjct: 258 ERKQEMQKVGWIYFLFLFLYSGL------EFTLPFLTHIR--FDFDNMQQGKVYLFTGLL 309
Query: 260 MGSISSYFIGYINSFYKKDV-DYSLRS-LHVFLLLSISLTGLIVSINVYNYVIWLIPLAM 317
M I + ++ +K V ++ + + +LL++++ T L++ ++ Y I A
Sbjct: 310 MLPIQAKYVRKTPIEKQKAVAEFGIACIIPAYLLVAVAKTPLVLYAGLFFYAI-----AS 364
Query: 318 GNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVS--YVIY 375
V+ L +L V+ +G L G S+ L+ + P+++ LG + Y++
Sbjct: 365 ATVVTSLTSLVHVIYPQ--SEKGVLAGIFRSLGCLARALGPVISSTFFWLLGATTCYIMG 422
Query: 376 ASL 378
A L
Sbjct: 423 AFL 425
>UniRef50_A0B6G9 Cluster: Major facilitator superfamily MFS_1;
n=1; Methanosaeta thermophila PT|Rep: Major facilitator
superfamily MFS_1 - Methanosaeta thermophila (strain
DSM 6194 / PT) (Methanothrixthermophila (strain DSM
6194 / PT))
Length = 387
Score = 44.4 bits (100), Expect = 0.005
Identities = 21/55 (38%), Positives = 33/55 (60%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
V +L ++ P+ P +V MGA H+ +G++ SIY QL + G LSD +GR+
Sbjct: 17 VSVLGFAVVAPIFPLYVLDMGATHLMLGMIISIYGAVQLLTQMPAGRLSDQRGRK 71
Score = 42.3 bits (95), Expect = 0.022
Identities = 31/136 (22%), Positives = 52/136 (38%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
MV + G + L+P +G +G+L YAG + G ++DL RR
Sbjct: 220 MVPGIIGGFNMTLLPELALSVGVGVSQLGILYMAYAGSNALANIYFGRVADLGHRRLLIS 279
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
C + + VLG A +V Y + +++ EI+G
Sbjct: 280 GGSLGCVLGFLVLGHGQGILPQLIALTILGLSSGICTPAATVVVSYITSPERRGEIFGIF 339
Query: 121 AAISGVGITLGPMIGG 136
+G+ +GP+I G
Sbjct: 340 NTSRMLGVVIGPIIAG 355
Score = 36.3 bits (80), Expect = 1.4
Identities = 23/84 (27%), Positives = 40/84 (47%)
Query: 309 VIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFL 368
+I L L + + + +V + + RG + G N+ R L V+ P++AG T
Sbjct: 302 LIALTILGLSSGICTPAATVVVSYITSPERRGEIFGIFNTSRMLGVVIGPIIAGLTADLG 361
Query: 369 GVSYVIYASLAPTVLGLVMSYHYR 392
G++ I A LA ++L M+ R
Sbjct: 362 GLAGAITAFLAVSLLISAMTLSLR 385
>UniRef50_UPI0000DAE55E Cluster: hypothetical protein
Rgryl_01000616; n=1; Rickettsiella grylli|Rep:
hypothetical protein Rgryl_01000616 - Rickettsiella
grylli
Length = 394
Score = 44.0 bits (99), Expect = 0.007
Identities = 72/343 (20%), Positives = 135/343 (39%), Gaps = 32/343 (9%)
Query: 25 HIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVA--YTVLGL-TXXXXX 81
H Y L S+ F ++G+LSDL GR+ ++A ++ +G+ T
Sbjct: 26 HFYYNLAISLPTIFVCMGALILGALSDLIGRKMVLLIGLLGVAIACLFSAIGVKTHNIIL 85
Query: 82 XXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPM---IGGHI 138
+ +A+A + D NN++K + AIS +G LGP+ I I
Sbjct: 86 FLIGRVLMGIMDGNEAVAQACMADLSNNKEKAINMSYVSLAIS-LGFILGPLASTILNRI 144
Query: 139 MED----NPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLS 194
+ P+ F I+ FIF ++CFL + + L+
Sbjct: 145 RQPFFLMEPSLPFYMSTLILFFGFIF---ILCFLKIPKTQRRNNQKKIVSNFIQACLIAI 201
Query: 195 LFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVI 254
+ +L+ I + W I+ A Y+ N +++ +S ++
Sbjct: 202 KSRQLRSMISILFCIQVA--WGIYFQSA------SAYFVN--VFIPPPVAISFFFLVMAF 251
Query: 255 SFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIP 314
+F + + Y++S Y V V ++LS S+ LI++ N + + I
Sbjct: 252 TFALTFTILIRVAMQYLSSNYLIIVGL------VSIILSASI--LIMAKNYHTFYYACIM 303
Query: 315 LAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVA 357
+A+G +S L ++ +D +G +IG + S S ++A
Sbjct: 304 IAIGVGISSNTILVLISNATDQSAQGQIIGLTLSFTSAGWLIA 346
>UniRef50_Q58955 Cluster: Uncharacterized MFS-type transporter
MJ1560; n=2; Methanococcales|Rep: Uncharacterized
MFS-type transporter MJ1560 - Methanococcus jannaschii
Length = 386
Score = 44.0 bits (99), Expect = 0.007
Identities = 75/393 (19%), Positives = 163/393 (41%), Gaps = 42/393 (10%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
+L VG I P++ + + +GA ++ +GL+ +A + + +G LSD+ G++
Sbjct: 19 MLGVGFIAPIMAIYAQTLGATNLEIGLIFGSFALARTVAQIPVGVLSDIYGKKFFIVCGT 78
Query: 64 XXCSVAY-------TVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEI 116
V+ TVLG + + A + P + + E
Sbjct: 79 FFYGVSTLMYNFVSTVLGFLIVRIFTGIFSAFVTPVAGSYIAA--IAP-----KTRLGEY 131
Query: 117 YGKMAAISGVGITLGPMIGGHIMED--NPNGAFMFIAFIVGICFIFNAALVCFLXXXXXX 174
G + +G +GP IGG I+ D F F F+ GI AA++ ++
Sbjct: 132 MGIFNSAITLGFGIGPFIGG-ILADMYGIKMPFYFCGFL-GIL----AAIISYMKLEDIV 185
Query: 175 XXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSN 234
+ + + +LF SF L + N+S + I + ++ + Y +
Sbjct: 186 FNKNK-----EKIDVKKISTLF-----SFEFLKNRNFSSSFIINVSNVMINAGIYAYLAL 235
Query: 235 YALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSI 294
YA+ Y+++ VG++I+ ++ ++ G + Y K + + + +F++ S
Sbjct: 236 YAI----NYNITISQVGFMIALTNILMALLQRSFGKL---YDK-LGNIMIIIGIFII-SF 286
Query: 295 SLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSG 354
+ L S + L +A+G+++S T + +K +G +G + ++
Sbjct: 287 GMYLLSTSTTFLTILASLTIIAVGSSISSTATTSLAVKDIPTHRKGEAMGLFTTSINIGM 346
Query: 355 VVAPMVAGFTGQFLGVSYVI-YASLAPTVLGLV 386
+ + GF LG++ + ++++ V+G++
Sbjct: 347 FIGAVSFGFLADILGIANMYKFSAIFSIVVGII 379
>UniRef50_UPI0000E4A5F1 Cluster: PREDICTED: similar to MGC84630
protein, partial; n=4; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to MGC84630 protein,
partial - Strongylocentrotus purpuratus
Length = 396
Score = 43.6 bits (98), Expect = 0.009
Identities = 25/112 (22%), Positives = 49/112 (43%), Gaps = 1/112 (0%)
Query: 26 IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXX 85
++ G+LGS+++ Q + P+IG+ SD+ GRR +++Y + ++
Sbjct: 97 LFGGVLGSLFSLLQFVTSPVIGAASDVYGRRSVMLVTMVGIALSYVLWAMSYNFGIFVLA 156
Query: 86 XXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGH 137
K L+ +V D + + + + VG +GPMIG +
Sbjct: 157 RIVGGIFKGNVSLSTTIVTDISTTKNR-GKGMAMIGLAFSVGFIVGPMIGAY 207
>UniRef50_A4SYC7 Cluster: Major facilitator superfamily MFS_1; n=2;
Burkholderiales|Rep: Major facilitator superfamily MFS_1
- Polynucleobacter sp. QLW-P1DMWA-1
Length = 410
Score = 43.6 bits (98), Expect = 0.009
Identities = 48/173 (27%), Positives = 87/173 (50%), Gaps = 23/173 (13%)
Query: 199 FKQSFVVLYSINWSKYWDIFLYKALV---GFAMGVYYSNYALYLKTTYDLSPKYVGYVIS 255
FKQ + VL + ++ FL+ LV GF++ Y ALYL ++ Y+ +
Sbjct: 210 FKQIYEVLIA---HRHLRAFLFIGLVMMTGFSVIPYI---ALYLTANVGVANSYISLIYL 263
Query: 256 FQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLS-ISLTGLIVSINVYNYVIWLIP 314
GV +SS FIG++ + K + VF +L+ ISL ++++ N+ +W++
Sbjct: 264 CGGVATLMSSRFIGHMADKFGK--------VRVFQVLAIISLAPILITTNLGPVPLWIVL 315
Query: 315 L---AMGNAVS-RLV-TLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG 362
+ A +S R++ T+ +V + + RGT + SV+ L+ +A +VAG
Sbjct: 316 INQTAFFILISGRMIPTMAIVSQMVEPKIRGTFMSLVGSVQMLASGIASVVAG 368
>UniRef50_A4M6X8 Cluster: Major facilitator superfamily MFS_1; n=1;
Petrotoga mobilis SJ95|Rep: Major facilitator
superfamily MFS_1 - Petrotoga mobilis SJ95
Length = 400
Score = 43.6 bits (98), Expect = 0.009
Identities = 35/165 (21%), Positives = 75/165 (45%), Gaps = 9/165 (5%)
Query: 213 KYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYIN 272
K ++ ++ ++ +Y + L+L+ + +++G + SF+ + +I IG +
Sbjct: 7 KVINLLIFSSISSSFWAIYRVVFNLFLRDL-GYTNQFIGRMTSFEMLGAAILGILIGILG 65
Query: 273 SFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVS--RLVTLEMV 330
K + S+ +LL LI S Y ++ ++ G ++ RL+ +
Sbjct: 66 DRIGKKKMIIISSISFGILL------LIRSTFPYKNILLILGFLNGGFMTSRRLLLDSYL 119
Query: 331 LKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIY 375
+ +D RG G + ++ SGV+ V GF G++LG+ +Y
Sbjct: 120 MDVTDSSTRGAAFGYNFAIFMASGVLGNFVGGFMGEYLGLGLTLY 164
>UniRef50_Q8RBR4 Cluster: Permeases of the major facilitator
superfamily; n=3; Thermoanaerobacter|Rep: Permeases of
the major facilitator superfamily - Thermoanaerobacter
tengcongensis
Length = 464
Score = 43.2 bits (97), Expect = 0.012
Identities = 25/108 (23%), Positives = 56/108 (51%), Gaps = 2/108 (1%)
Query: 284 RSLHVFLLLSISLTGLIVSI--NVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGT 341
+ L+ + LL+ S++ LI+S+ N+Y +I A+G A+ ++ ++ + RG
Sbjct: 75 KKLYEYGLLTFSISSLILSLSANIYMLIIMRAIQAVGAAMLMSMSSAIITSVFPPNERGK 134
Query: 342 LIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSY 389
+G + S+ + P + GF ++LG + Y ++ V+G + ++
Sbjct: 135 ALGINAMAISIGLAIGPTLGGFLLKYLGWPSIFYINVPIGVIGYIWAH 182
>UniRef50_Q2W6Q6 Cluster: Permease of the major facilitator
superfamily; n=2; Magnetospirillum|Rep: Permease of the
major facilitator superfamily - Magnetospirillum
magneticum (strain AMB-1 / ATCC 700264)
Length = 424
Score = 43.2 bits (97), Expect = 0.012
Identities = 38/147 (25%), Positives = 57/147 (38%), Gaps = 4/147 (2%)
Query: 13 LVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTV 72
+V V++ G G+ S L SGP+ GSLSD GRR + AY +
Sbjct: 265 IVTALVQERGFPESTAGMFWSWIGFLSLASGPVFGSLSDRIGRRAGLMIVFSCQAAAYVL 324
Query: 73 LGLTX-XXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLG 131
+ L + A V DY EQ A +G + I +G G
Sbjct: 325 VALPLPEPFLYASIALFGLVVWAVPSIMAAAVGDYLGPEQ-AASSFGTITLIFALGQICG 383
Query: 132 PMIGGHIME--DNPNGAFMFIAFIVGI 156
P + G + + + +GAF A + G+
Sbjct: 384 PAVAGWMADAWGSFSGAFAMAAAVAGL 410
>UniRef50_Q2AIY8 Cluster: Major facilitator superfamily MFS_1
precursor; n=1; Halothermothrix orenii H 168|Rep: Major
facilitator superfamily MFS_1 precursor -
Halothermothrix orenii H 168
Length = 400
Score = 43.2 bits (97), Expect = 0.012
Identities = 80/390 (20%), Positives = 148/390 (37%), Gaps = 32/390 (8%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
+L ++IP P + + +VGLL ++++ + P +G L D GR
Sbjct: 20 VLGNSMLIPEFPQIKAALDIDQFHVGLLITVFSISAGITIPFLGYLCDQIGRIKVIVPSL 79
Query: 64 XXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQ------TQMLAKALVPDYENNEQKQAEIY 117
+ + G+ Q T + ALV D +EQ+ +E
Sbjct: 80 LLYGLGGIISGVAALIMDNPYNIILIGRVVQGVGAAGTAPIVMALVGDIFQSEQR-SEAL 138
Query: 118 GKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXX 177
G + A +G+G + P++G I G +IA F F L +
Sbjct: 139 GIIEAANGIGKVVSPILGSAI------GLISWIAL-----FFFYVFLAIPIAAGVWFWGK 187
Query: 178 XXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYAL 237
L + L ++ FK+ + L S +F+ L+ Y+S++
Sbjct: 188 EVKEKGQQSLKKYL-RNVGEIFKEKGLSLIMTILSGMLVLFILFGLLS-----YFSDF-- 239
Query: 238 YLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLT 297
L+ +++ G VI+ + S +SY GYI KK S+ + + + L++ +
Sbjct: 240 -LEAKHNIKGFVKGLVIAIPILFMSTTSYINGYILKKVKKYFKASIITGLIIIPLALIIL 298
Query: 298 GLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVA 357
I S+ Y + L+ + G + + TL V + D RG + S R + +
Sbjct: 299 SFIKSLTTYLVLFSLLGIGTGLVLPAINTL--VTSSTKADQRGVITSIYGSARFVGVAIG 356
Query: 358 PMVAGFTGQFLGVSYVIYASLAPTVLGLVM 387
P F + L + + Y + G++M
Sbjct: 357 PPAFSFLEE-LSLKTMYYG--GSLIAGIIM 383
Score = 33.5 bits (73), Expect = 10.0
Identities = 33/161 (20%), Positives = 68/161 (42%), Gaps = 4/161 (2%)
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLS-ISLT 297
+K D+ +VG +I+ + I+ F+GY+ + + + SL ++ L IS
Sbjct: 33 IKAALDIDQFHVGLLITVFSISAGITIPFLGYLCDQIGR-IKVIVPSLLLYGLGGIISGV 91
Query: 298 GLIVSINVYNYV-IWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVV 356
++ N YN + I + +G A + + + +V + R +G + + VV
Sbjct: 92 AALIMDNPYNIILIGRVVQGVGAAGTAPIVMALVGDIFQSEQRSEALGIIEAANGIGKVV 151
Query: 357 APMVAGFTGQFLGVS-YVIYASLAPTVLGLVMSYHYRTKRK 396
+P++ G ++ + Y LA + V + K K
Sbjct: 152 SPILGSAIGLISWIALFFFYVFLAIPIAAGVWFWGKEVKEK 192
>UniRef50_A6LMN9 Cluster: Major facilitator superfamily MFS_1; n=1;
Thermosipho melanesiensis BI429|Rep: Major facilitator
superfamily MFS_1 - Thermosipho melanesiensis BI429
Length = 384
Score = 43.2 bits (97), Expect = 0.012
Identities = 39/182 (21%), Positives = 77/182 (42%), Gaps = 7/182 (3%)
Query: 217 IFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYI-NSFY 275
I + + G + +Y + LYLK +G V+SF ++ IG + +
Sbjct: 7 IIFFTLINGISGNIYQVLFNLYLKDL-GYHNDIIGNVMSFNLWGSAVLGLIIGILADRIG 65
Query: 276 KKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSD 335
+K V + ++ L +F + + + +++ NA RL+T +++ +
Sbjct: 66 RKRVLFIVQPLVIFFAIMRLFPSNLTLLYFFSFFFGGF-----NASIRLLTDVFLVESTS 120
Query: 336 GDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTKR 395
+R G + V L+GV+ + GF G F G V++ ++ LV + + KR
Sbjct: 121 HGNRAKYFGINFGVNMLTGVLGNSIGGFLGDFFGFRKVMFFAMLLRSFALVPILNLKEKR 180
Query: 396 KV 397
V
Sbjct: 181 NV 182
>UniRef50_Q0W2N8 Cluster: Putative permease; n=1; uncultured
methanogenic archaeon RC-I|Rep: Putative permease -
Uncultured methanogenic archaeon RC-I
Length = 395
Score = 43.2 bits (97), Expect = 0.012
Identities = 32/142 (22%), Positives = 63/142 (44%), Gaps = 4/142 (2%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGANHIYVGLL-GSIYAGFQLGSGPLIGSLSDLKGRRXXX 59
++D++ L+IP++P + +GA+ + +G++ G+ L S P G+LSD GRR
Sbjct: 18 LIDMMMYTLVIPILPAYATTLGADEMMIGVIFGAFSIALLLFSIP-FGALSDRVGRRPLL 76
Query: 60 XXXXXXCSVAYTVLGLT-XXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYG 118
++ V ++ T AL+ D + ++ +++ G
Sbjct: 77 VAGMFLLALTNLVFVISDNLYLLIVARVIQGISGAATWSAGLALIADTFDASERGSKL-G 135
Query: 119 KMAAISGVGITLGPMIGGHIME 140
AI G GP++GG + +
Sbjct: 136 MAMAIMSAGTLSGPVVGGIVYD 157
Score = 35.5 bits (78), Expect = 2.5
Identities = 30/143 (20%), Positives = 55/143 (38%), Gaps = 4/143 (2%)
Query: 1 MVDLLAVGLIIPLVPGHV-RKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXX 59
+V L GL+ P +P ++ K A +GL + + + P++G+L D G R
Sbjct: 214 IVGALTFGLLEPFMPLYLFEKFSATPTLIGLAFGAMSLLNMVAAPVVGNLYDRFGGRGLL 273
Query: 60 XXXXXXCS--VAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNE-QKQAEI 116
+A T+L + + L + E Q +
Sbjct: 274 ASGLVLSGLIIALTMLMPSMELTILAFAIVGVTMSMALTPMLPLLTDLFGGPEGSSQGFL 333
Query: 117 YGKMAAISGVGITLGPMIGGHIM 139
YG + +G+T+GP +GG ++
Sbjct: 334 YGIYNTLFSIGLTIGPFLGGALV 356
Score = 34.7 bits (76), Expect = 4.3
Identities = 25/108 (23%), Positives = 46/108 (42%), Gaps = 2/108 (1%)
Query: 284 RSLHVFLLLSISLTGLI--VSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGT 341
R L V + ++LT L+ +S N+Y ++ + + A + L ++ D RG+
Sbjct: 73 RPLLVAGMFLLALTNLVFVISDNLYLLIVARVIQGISGAATWSAGLALIADTFDASERGS 132
Query: 342 LIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSY 389
+G + ++ S + P+V G LG T+L M Y
Sbjct: 133 KLGMAMAIMSAGTLSGPVVGGIVYDLLGYRMTFVLPSVLTILLGCMFY 180
>UniRef50_Q2SGJ5 Cluster: Permease of the major facilitator
superfamily; n=1; Hahella chejuensis KCTC 2396|Rep:
Permease of the major facilitator superfamily - Hahella
chejuensis (strain KCTC 2396)
Length = 414
Score = 42.7 bits (96), Expect = 0.016
Identities = 70/369 (18%), Positives = 147/369 (39%), Gaps = 26/369 (7%)
Query: 24 NHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXX- 82
N +Y LG+ G+ PL+G+LSD GR+ +++Y L L
Sbjct: 51 NGVYGVALGAFSIAMFFGA-PLLGALSDGLGRKKTLLLCLSGLAMSYVFLALALAFKSLW 109
Query: 83 --XXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIME 140
+ +A+A + D E+++A+ G + +G +GP+IGG++ +
Sbjct: 110 LFMAGRLIGGFFSGSLPVAQASIIDV-TEEKQRAKYIGYIMFFVSLGYVVGPLIGGYLSD 168
Query: 141 DNPNGAFMFIAFIVGICFIFNAAL--VCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNS 198
+ F + FIF AAL V L + N + +L ++
Sbjct: 169 -----PALVPWFNLQTPFIFVAALSVVNLLILLLVFQDQKRDAESRAMTLPNPIANLLDA 223
Query: 199 FKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQG 258
+ + Y+ + L LVG+ ++ LYL + V +S+ G
Sbjct: 224 VRIKDIRTYA--------LLLLLMLVGW--NTFFQFIGLYLTGGLGFGQQEVSSFVSWVG 273
Query: 259 VMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMG 318
+++ F+ + + K + L L+++ + G ++S + Y + + A+G
Sbjct: 274 F--GLAAAFLFLVGAAMKMLKPLGMVGL-ALTLMALCIGGTLLSTHPYALYLLAVLGAVG 330
Query: 319 NAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASL 378
+S + + D +G+++G + ++ + S + GF + V+ I ++L
Sbjct: 331 FGLSYSGLMAQLSISVDASRQGSMMGMAAAIAAFSAGFSGFAFGFVAN-ISVNAPIVSAL 389
Query: 379 APTVLGLVM 387
L +++
Sbjct: 390 LCVCLAILV 398
>UniRef50_A7PP07 Cluster: Chromosome chr8 scaffold_23, whole genome
shotgun sequence; n=5; Magnoliophyta|Rep: Chromosome
chr8 scaffold_23, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 434
Score = 42.7 bits (96), Expect = 0.016
Identities = 41/161 (25%), Positives = 70/161 (43%), Gaps = 8/161 (4%)
Query: 215 WDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSF 274
W I + V S +Y K+ +D++ K + + M +IS Y G ++ +
Sbjct: 245 WAIIFANITNNWGYFVLLSWMPVYFKSVFDINLKQAAWFSAAPWGMMAISGYIAGVVSDY 304
Query: 275 YKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAM----GNAVSRLVTLEMV 330
K V Y L + ++ SI G VS+ N+ + AM G ++S +
Sbjct: 305 LIK-VGYPLTLVRK-IMQSIGFIGPGVSLLCLNHAKTPVTAAMFLTAGLSLSSFSQAGFL 362
Query: 331 LKRSD--GDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLG 369
L D + G L G SNS +L+ +V+ + G+ Q+LG
Sbjct: 363 LNMQDIAPQYAGFLHGISNSAGTLAAIVSTIGTGYFVQWLG 403
>UniRef50_Q54IT2 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 464
Score = 42.7 bits (96), Expect = 0.016
Identities = 63/325 (19%), Positives = 129/325 (39%), Gaps = 20/325 (6%)
Query: 43 GPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKAL 102
GPL+G+LSD GR+ + +T + A A+
Sbjct: 102 GPLLGNLSDKYGRKPIMYIGIGSSILDVVACIITVKTNCLYFFYVSHTFAGISNAAAAAI 161
Query: 103 VPDYEN-NEQKQAE-IYGKMAAISGVGITLGPM--IGGHIMEDNPNGAFMFIAFIVGICF 158
++ +E+ Q +Y + A G+G+ GP+ IG + + + + I + G
Sbjct: 162 FSFLKDLSEEDQLPLLYSLLGASIGIGVITGPLIFIGLSSLSLSSSSSSYIILLVAGGLM 221
Query: 159 IFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIF 218
I +++ FL + S N L+ F K F I++ +
Sbjct: 222 ILCISIIPFLKESTENAKLEKKINTNN--SNNQTLNPFKLIKNLFSNSPFISF-----VI 274
Query: 219 LYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSI-SSYFIGYINSFYKK 277
L L+ F+ ++Y Y + Y+ K G + QGV I I + ++
Sbjct: 275 LIYVLMSFSSEDVNTSYYFYSELMYNWGSKENGLYLGSQGVFIIIWGVLIIPILLKYFSP 334
Query: 278 DVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAM-GNAVSRLVTLEMVLKRS-D 335
S+ ++V ++ ISL + Y+ +W++ A+ N + L ++ ++ S
Sbjct: 335 RKTVSI-GINVGIIAHISLV-----FSGYSKYLWILGSALNANGTNNLSLIQSIVSNSIP 388
Query: 336 GDHRGTLIGASNSVRSLSGVVAPMV 360
+ +GT+I + ++ S++ +A ++
Sbjct: 389 YNLQGTIITGTQAIGSMATFLASLI 413
>UniRef50_Q3Y153 Cluster: Major facilitator superfamily; n=2;
Lactobacillales|Rep: Major facilitator superfamily -
Enterococcus faecium DO
Length = 310
Score = 42.3 bits (95), Expect = 0.022
Identities = 42/160 (26%), Positives = 73/160 (45%), Gaps = 9/160 (5%)
Query: 235 YALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDY-SLRSLHVFLLLS 293
YA +L Y S VG+V GV+ +I+S F+ + +K Y ++ + V ++
Sbjct: 149 YAPFLLIGY--SELEVGFVFFGWGVLLAIASIFVA--PALERKFTTYRTILAAFVLFIIC 204
Query: 294 ISLTGLIVSINVYNYV-IWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSL 352
+ L G S+ V + I L G + L T+ M + G R + + VR
Sbjct: 205 LLLLGAGTSMPVLVPISIVLAGFFQGIINTLLTTIAMEIP---GLQRNVASSSYSFVRFF 261
Query: 353 SGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYR 392
G +AP +AG G+ +G SY Y + A ++ + ++R
Sbjct: 262 GGALAPFIAGVIGEHIGESYAFYFAGAIVLISVCCIIYHR 301
>UniRef50_Q0RV66 Cluster: Multidrug resistance transporter, MFS
superfamily; n=2; Rhodococcus sp. RHA1|Rep: Multidrug
resistance transporter, MFS superfamily - Rhodococcus
sp. (strain RHA1)
Length = 408
Score = 42.3 bits (95), Expect = 0.022
Identities = 41/155 (26%), Positives = 64/155 (41%), Gaps = 5/155 (3%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGL-LGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
+A G+ +P +P +G ++I V L L + G LG L G+LSD GRR
Sbjct: 22 VATGVYLPGLPSIASALGTSNIGVQLTLTTFMVGLGLGQ-LLAGALSDSWGRRRLLLGGS 80
Query: 64 XXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQT-QMLAKALVPDYENNEQKQAEIYGKMAA 122
+VA V L +LA+A++ D + A ++ M
Sbjct: 81 VAFTVASAVCALAPTIGVLTVARLIAGFSGGIGVVLARAVISDRARGIE-AARLFSVMMI 139
Query: 123 ISGVGITLGPMIGGHIMED-NPNGAFMFIAFIVGI 156
I GV + P++GG ++ G F + I GI
Sbjct: 140 IGGVAPVIAPVLGGMLLGPIGWRGTFWVLTAIGGI 174
>UniRef50_A6BZ30 Cluster: Major facilitator superfamily MFS_1
transporter; n=1; Planctomyces maris DSM 8797|Rep: Major
facilitator superfamily MFS_1 transporter - Planctomyces
maris DSM 8797
Length = 432
Score = 42.3 bits (95), Expect = 0.022
Identities = 66/371 (17%), Positives = 143/371 (38%), Gaps = 27/371 (7%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+DLL G+++PL+P + A +GLL + ++ Q P+ G +SD GRR
Sbjct: 18 IDLLGFGIVLPLLPRYGEHFEAGGTTLGLLMASFSAMQFLFAPVWGRISDRVGRRPILIL 77
Query: 62 XXXXCSVAYTVLGLTXXXXXX-----XXXXXXXXXXKQTQMLAKALVPDYE------NNE 110
+ Y + G + +A A +P +
Sbjct: 78 GLLGSTFFYGMFGFATSLGKTGMFLGIDALSWLFITRIGAGIAGATIPTAQAYIADITGP 137
Query: 111 QKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXX 170
+++ + + A G+G T GP+IG + GA A C + A + +
Sbjct: 138 KERGKGMALIGAAFGIGFTFGPLIGAAFVSAE-TGATPSAAPGYVACVLSGMAALLSI-- 194
Query: 171 XXXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGV 230
D L+ SF+ +++ + I L L FA
Sbjct: 195 --FILPESLTKKTTDSLARRHHWFDITSFR------HALTQPRIGLILLAIFLTTFAFAQ 246
Query: 231 YYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFL 290
+ S +L L + + ++ ++ G + ++S F+ + + +Y + + L
Sbjct: 247 FESTLSL-LTQELGFAARSNFFIFAYIGFILTLSQGFL--VRRLIPRLGEYRMGLFGIVL 303
Query: 291 L-LSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGD-HRGTLIGASNS 348
+ + + L G+ + Y + ++P+++ + +L+ +L + D +G ++G S
Sbjct: 304 MVIGLLLIGVAGNSGSYTMLYAVLPISVIGFSATTPSLQSLLSLNTSDAEQGGILGVGQS 363
Query: 349 VRSLSGVVAPM 359
+ +L+ ++ P+
Sbjct: 364 ISALARILGPL 374
>UniRef50_Q9Y918 Cluster: Putative MFS transporter; n=1; Aeropyrum
pernix|Rep: Putative MFS transporter - Aeropyrum pernix
Length = 395
Score = 42.3 bits (95), Expect = 0.022
Identities = 37/169 (21%), Positives = 80/169 (47%), Gaps = 7/169 (4%)
Query: 220 YKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIG-YINSFYKKD 278
Y GFA+G Y + + +Y+++ S + +G VI+ ++ ++ +G YI+ +
Sbjct: 6 YNVFRGFAVGGYMALFPMYMRSL-GYSMENIGGVIAVSSLVSALVLPAVGVYIDRMGPRT 64
Query: 279 VDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDH 338
L + F ++I + ++ +Y+++L+ G SR+ + + D
Sbjct: 65 W-VILTGVLQFAGIAILIPDPSIAGLTSSYLLFLLSFMAGQP-SRM---SFLARSIDVSS 119
Query: 339 RGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVM 387
G ++G ++SV S S +V P G+ + LG A +++GL++
Sbjct: 120 LGYIVGVTSSVFSASRLVGPAAGGYISEALGFQGAFEVLAASSLVGLML 168
>UniRef50_Q8TUA4 Cluster: Class H tetracycline resistance efflux
protein; n=7; cellular organisms|Rep: Class H
tetracycline resistance efflux protein - Methanosarcina
acetivorans
Length = 450
Score = 42.3 bits (95), Expect = 0.022
Identities = 18/55 (32%), Positives = 30/55 (54%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
+ L +++P + V ++G N GL S+Y FQL P++G SD+ GR+
Sbjct: 35 IGTLGFSIVLPFLVFLVNRLGGNAFIYGLASSMYPAFQLIGAPILGRWSDIYGRK 89
>UniRef50_Q9KFK7 Cluster: BH0472 protein; n=1; Bacillus
halodurans|Rep: BH0472 protein - Bacillus halodurans
Length = 417
Score = 41.9 bits (94), Expect = 0.028
Identities = 36/117 (30%), Positives = 58/117 (49%), Gaps = 9/117 (7%)
Query: 281 YSLRSLHVFLLLSISLTGLIVSINV---YNYVIWLI-PLAMGNAVS--RLVTLEMVLKRS 334
Y +L LL+++SLT L+ +I Y + +W+I L G A S RL L VL+ +
Sbjct: 71 YQHVTLRTGLLIAVSLT-LVTTIGYGVGYGFFVWVILRLLWGIAWSFLRLGGLFTVLEEA 129
Query: 335 DGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVS--YVIYASLAPTVLGLVMSY 389
+RG L+G N + L + + G F+G+S +I+ LA + V+ Y
Sbjct: 130 TDSNRGKLMGQYNGLYRLGSLGGMLGGGILASFIGLSATAIIFGVLAVLAIPYVLRY 186
>UniRef50_Q81YJ0 Cluster: Major facilitator family transporter;
n=13; Bacillus cereus group|Rep: Major facilitator
family transporter - Bacillus anthracis
Length = 404
Score = 41.9 bits (94), Expect = 0.028
Identities = 42/168 (25%), Positives = 79/168 (47%), Gaps = 10/168 (5%)
Query: 223 LVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYS 282
L+ + +GV+ AL+ K Y L+ G ++S V FIG + Y + + S
Sbjct: 26 LITYGVGVF----ALFWKEEYALTNMESGLLVSVVNVGPLFCMLFIGRLLDQYNEKILIS 81
Query: 283 LRSLHVFLL-LSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGT 341
+ S FLL S+ LT ++ N +V+ LI M +VS+ +++LK ++RG
Sbjct: 82 ISS---FLLGSSLLLTNIVSGFNGLLFVLLLI--GMFYSVSQPGGSKVILKWFPKENRGL 136
Query: 342 LIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSY 389
+G + + G +A ++ F ++Y I + ++G V+ +
Sbjct: 137 AMGIRQAGIPIGGALAGVLIPFLTVQYNMTYAINSIACICIIGGVLFF 184
>UniRef50_P73784 Cluster: Quinolene resistance protein; NorA; n=1;
Synechocystis sp. PCC 6803|Rep: Quinolene resistance
protein; NorA - Synechocystis sp. (strain PCC 6803)
Length = 418
Score = 41.9 bits (94), Expect = 0.028
Identities = 39/149 (26%), Positives = 65/149 (43%), Gaps = 5/149 (3%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVG-LLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
L++ ++P +P + + +GA VG ++GS G LGS IG L D +GR+
Sbjct: 30 LSLTALLPTLPMYAQDVGATKQQVGWIMGSFALGL-LGSRIWIGQLVDRRGRKIAIVIGA 88
Query: 64 XXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLA-KALVPDYENNEQKQAEIYGKMAA 122
++A LT +LV D + Q++ EI G M+
Sbjct: 89 LVVALAPLGYLLTATVGALMAIRAFHGICLAAYTTGYNSLVVDL-SPPQQRGEIIGYMSL 147
Query: 123 ISGVGITLGPMIGGHIMEDNPNGAFMFIA 151
+G+ GP +G +I + + F+FIA
Sbjct: 148 AVPIGMGFGPAVGAYISQ-SIGYEFLFIA 175
>UniRef50_Q183L2 Cluster: Putative polysaccharide polymerase; n=2;
Clostridium difficile|Rep: Putative polysaccharide
polymerase - Clostridium difficile (strain 630)
Length = 385
Score = 41.9 bits (94), Expect = 0.028
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 213 KYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGY-- 270
K+W ++L A G + + ++Y+ +K T L YV Y+IS GV+ I ++ Y
Sbjct: 267 KFWHVYL--AEKGNFLKPFGNSYSPAIKATNPLDSSYV-YIISVLGVVACILFMYLMYKG 323
Query: 271 INSFYKKDVDYSLRSLHVFLLLSIS 295
I SF +KD L +L +FLL S +
Sbjct: 324 IESFIEKDKKAYLVALFIFLLYSFA 348
>UniRef50_Q9A9E1 Cluster: Multidrug resistance protein, putative;
n=2; Caulobacter|Rep: Multidrug resistance protein,
putative - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 396
Score = 41.5 bits (93), Expect = 0.038
Identities = 34/131 (25%), Positives = 50/131 (38%), Gaps = 1/131 (0%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
++L+ G+IIPL+P + R M A V + + Y+ Q P G LSD GRR
Sbjct: 20 INLVGFGVIIPLLPFYARSMDAAPRQVTTMFAAYSLGQFFGEPFWGRLSDRIGRRPVLIV 79
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
++AY L + + D E K+A G +
Sbjct: 80 TIIANTLAYLALAFAPNIWVAMLIRLFGGFGSGNISTIQGYMADVTPPE-KRAGRMGLLG 138
Query: 122 AISGVGITLGP 132
A G G +GP
Sbjct: 139 AAFGAGFVIGP 149
>UniRef50_Q9LA76 Cluster: Valanimycin resistance; n=1; Streptomyces
viridifaciens|Rep: Valanimycin resistance - Streptomyces
viridifaciens
Length = 402
Score = 41.5 bits (93), Expect = 0.038
Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 6/163 (3%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
L L PL G+ K G + + V L+ ++Y + S + G LSD GRR
Sbjct: 33 LTGTNLPTPLYRGYEHKFGFSPLVVTLIFAVYVASLIPSLLIAGPLSDSIGRRKVLLPAV 92
Query: 64 XXCSVAYTVLGLTXXX--XXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMA 121
+V V L + L AL + ++++A + +A
Sbjct: 93 LLAAVGSLVFALADNVGWLFVARLLQGLAVGAASGALTAALSELEPSGDRRRAALVSTVA 152
Query: 122 AISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAAL 164
++ G+G GP+I G + E P+ + F+V I + AA+
Sbjct: 153 SVGGLG--AGPLIAGLLAEYAPSP--YVLPFVVEIVLLVPAAI 191
>UniRef50_A5K9J4 Cluster: Transporter, putative; n=6;
Plasmodium|Rep: Transporter, putative - Plasmodium vivax
Length = 442
Score = 41.5 bits (93), Expect = 0.038
Identities = 75/383 (19%), Positives = 152/383 (39%), Gaps = 25/383 (6%)
Query: 11 IPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAY 70
I ++P + GA + G L ++++ Q G L+D+ G + S+ Y
Sbjct: 51 IAMLPYMLISSGAGIEHNGYLLTLFSLLQFVGSTFFGRLADIWGVKKSFYLSLCSSSLMY 110
Query: 71 TVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITL 130
+L + Q A +L+ + + +K+ G + G+GI L
Sbjct: 111 LMLPACRATWAYYVSFLPSFFMQTFQ--ASSLLVCLKTDSEKRTAAIGYLNLSYGMGIIL 168
Query: 131 GPMIGGHIMED-NPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSE 189
G +I G ++ P G + IA I ++ A + D+
Sbjct: 169 GSLIAGLMVNYVGPRGNLL-IALGSQIAALYVAKTL------SEDPKLLKPVNLGDIKMR 221
Query: 190 NLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKY 249
++ S+ N + + VL + + + L+ M + +A + + L+P +
Sbjct: 222 EILSSIQNEYAR---VLNLFRKTYGMCLLILFGLLPILMTKFA--FAPVVVDMFKLTPSH 276
Query: 250 VGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFL--LLSISLTGLIVSINVYN 307
Y++++ G++ I+ + S D+ S+ + L L++SL G N Y
Sbjct: 277 TSYLMTYAGIVTIIAEGLLAPYLSSILGDITCCKYSVPLTLAGFLALSLCGA----NEYL 332
Query: 308 YVIWL-IPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQ 366
++++ IPL G A+ + + KR + GT IG + S+ +VAP +A
Sbjct: 333 VLLFMSIPLC-GGALLYICGTSQMTKRVEESELGTAIGLNTSIFYAVTIVAPYLA--FKS 389
Query: 367 FLGVSYVIYASLAPTVLGLVMSY 389
+L + +Y L + ++ +Y
Sbjct: 390 YLALGLGLYWLLCALICLVITTY 412
>UniRef50_Q0V4C7 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 497
Score = 41.5 bits (93), Expect = 0.038
Identities = 30/123 (24%), Positives = 53/123 (43%), Gaps = 2/123 (1%)
Query: 14 VPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVL 73
+ G+V K Y GL+ S+++ Q+ L G SD GR+ SVA T+
Sbjct: 91 IVGNVNKDEVG-FYSGLIESLFSATQMCVMLLWGKASDRYGRKPVLVLSLIGVSVATTLF 149
Query: 74 GLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPM 133
G++ T + +A++ + + + QA + A +G+ LGP+
Sbjct: 150 GMSQTLWQMIVARCFAGVFAGTVVTVRAMLSE-NSTKYTQARAFSYFAFARNLGLFLGPL 208
Query: 134 IGG 136
+GG
Sbjct: 209 LGG 211
>UniRef50_Q0W1D9 Cluster: Permease; n=1; uncultured methanogenic
archaeon RC-I|Rep: Permease - Uncultured methanogenic
archaeon RC-I
Length = 410
Score = 41.5 bits (93), Expect = 0.038
Identities = 20/54 (37%), Positives = 34/54 (62%)
Query: 3 DLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
D+L +I+P++P + +GA+ +GLL + YA L + P++G LSD GR+
Sbjct: 29 DMLIYCMIVPILPEYASGLGASQQMIGLLFASYAITFLLAAPVVGVLSDRVGRK 82
>UniRef50_Q2AID5 Cluster: General substrate transporter:Major
facilitator superfamily MFS_1; n=1; Halothermothrix
orenii H 168|Rep: General substrate transporter:Major
facilitator superfamily MFS_1 - Halothermothrix orenii H
168
Length = 423
Score = 41.1 bits (92), Expect = 0.050
Identities = 37/149 (24%), Positives = 65/149 (43%), Gaps = 11/149 (7%)
Query: 256 FQGVMGSISSYFIGYI-NSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIW--- 311
F G+ ++ F G++ + YKK VF+LL + ++ +N + W
Sbjct: 253 FLGIGATVGGIFGGWMGDKIYKKSPRMLPVFNAVFILLGVIPGFFLMGLNYGSDPGWNEL 312
Query: 312 LIPLAMGNAVSRLVTL------EMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTG 365
++PL +V+L +++ + +HRGT+ N SL V P++ GF
Sbjct: 313 ILPLIFSFCTGVVVSLPAPNIKSILINVNPPEHRGTVFSIHNLTDSLGRGVGPLIGGFLV 372
Query: 366 QFLGVSYVIY-ASLAPTVLGLVMSYHYRT 393
G + +Y A A GL+ + YRT
Sbjct: 373 VSQGYQWTMYFAVFAWIPCGLIYLWMYRT 401
>UniRef50_A7A924 Cluster: Putative uncharacterized protein; n=1;
Bifidobacterium adolescentis L2-32|Rep: Putative
uncharacterized protein - Bifidobacterium adolescentis
L2-32
Length = 493
Score = 41.1 bits (92), Expect = 0.050
Identities = 22/93 (23%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 298 GLIVSINVYNYVIWL---IPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSG 354
G +V N+ + L + +A+G VS + ++L+++ D RG ++G + V +
Sbjct: 119 GTVVGALAVNFPMLLAARLIMALGTGVSLPLLTNIILEKAPFDRRGMMLGLVSLVTCAAP 178
Query: 355 VVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVM 387
+ P+ G +FL ++ Y + +L LV+
Sbjct: 179 AIGPVFGGLVMEFLNWHWIFYTMIPFLILSLVL 211
>UniRef50_A0YM33 Cluster: General substrate transporter; n=4;
Cyanobacteria|Rep: General substrate transporter -
Lyngbya sp. PCC 8106
Length = 421
Score = 41.1 bits (92), Expect = 0.050
Identities = 30/130 (23%), Positives = 58/130 (44%), Gaps = 2/130 (1%)
Query: 10 IIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVA 69
++P +P +++ +G + VGL+ +A L S +G L+D KGR+ ++A
Sbjct: 32 LLPTLPLYIQALGGTNRQVGLVMGAFAIGLLPSRFGLGPLADSKGRKLVLLIGTTVVTLA 91
Query: 70 -YTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGI 128
L +T + ALV D + ++ E+ G M+ ++ +G+
Sbjct: 92 PLGYLWVTSIPSMAVIRAFHGVSLAAFTIGYSALVADIAPID-RRGEVIGYMSLVTPIGM 150
Query: 129 TLGPMIGGHI 138
+GP GG +
Sbjct: 151 AIGPAFGGFV 160
>UniRef50_A3H5L9 Cluster: Major facilitator superfamily MFS_1
precursor; n=1; Caldivirga maquilingensis IC-167|Rep:
Major facilitator superfamily MFS_1 precursor -
Caldivirga maquilingensis IC-167
Length = 399
Score = 41.1 bits (92), Expect = 0.050
Identities = 35/145 (24%), Positives = 63/145 (43%), Gaps = 4/145 (2%)
Query: 222 ALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDY 281
++ G G ++Y+ + P +G VI +M ++ S GY++ F K +
Sbjct: 18 SITGIMFGANSVILSIYM-LNIGMKPTLIGVVIGASSLMSALGSLITGYLSDFINKLSLF 76
Query: 282 SLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGT 341
+ SL L+ + +TGL I + V LI L N +S ++ E +R +
Sbjct: 77 TFLSLASGSLILLLVTGLPPVITM---VYPLIALLNRNVISIAISGEYARRRGISSEFFS 133
Query: 342 LIGASNSVRSLSGVVAPMVAGFTGQ 366
L + N V S+ G M+ + G+
Sbjct: 134 LSSSLNVVFSVIGSSITMLPSYMGR 158
>UniRef50_A7CRQ2 Cluster: Major facilitator superfamily MFS_1
precursor; n=1; Opitutaceae bacterium TAV2|Rep: Major
facilitator superfamily MFS_1 precursor - Opitutaceae
bacterium TAV2
Length = 462
Score = 40.7 bits (91), Expect = 0.066
Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 1/117 (0%)
Query: 26 IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXX 85
++ G++ S+++ Q P G LSD +GRR + +Y + L+
Sbjct: 96 LFGGVVSSLFSLLQFVFAPFWGGLSDRRGRRGVLLFTVTGTAGSYLLWALSGSFWVFLVA 155
Query: 86 XXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDN 142
+A A V D +++ A+ G + A G+G+ GP++G + N
Sbjct: 156 RLLGGAFGGNLSVATAAVADVTTRKER-AKAMGIVGAAFGLGLVTGPLVGAGAAQFN 211
>UniRef50_A6LNR2 Cluster: Putative uncharacterized protein; n=1;
Thermosipho melanesiensis BI429|Rep: Putative
uncharacterized protein - Thermosipho melanesiensis
BI429
Length = 402
Score = 40.7 bits (91), Expect = 0.066
Identities = 49/221 (22%), Positives = 105/221 (47%), Gaps = 20/221 (9%)
Query: 186 VLSENLVLSLFNSFKQSFVVL-----YSINWSKYWDIFLYKALVGFAMGVYYSNYALYLK 240
++ EN + +L N F VL Y + + ++ L GF + + Y L K
Sbjct: 194 LIKENKI-TLSNEFPSFLKVLKSIPKYLLRDKNLLNYVIFSNLTGFGL-IIIPFYVLLAK 251
Query: 241 TTYDLSPKYVGYVISFQGVMGSISSYFIGYI--NSFYKKDVDYSLRSLHVFLLLSISLTG 298
++ L K VG + Q ISS+ G + YKK + Y + + +L++ L+
Sbjct: 252 NSFSLDNKLVGNFLFLQMFGIIISSFLWGKLLHKQGYKKVLKYCVVLGSMLPILAVVLSN 311
Query: 299 LIVSINVYNYVIWLIPLAMGNAVSRLVTLE-MVLKRSDGDHRGTLIGASNSVRSLSGVVA 357
S +V++ + +L L + +R ++ E ++++ S ++R +G S ++ ++ ++
Sbjct: 312 F--SPSVFSIIFFLSGLTLS---ARQISFEGILIEISSHENRALYVGISGALNIVTALL- 365
Query: 358 PMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTKRKVD 398
P+V G + +G + +I+ S++ + + S + K K+D
Sbjct: 366 PLVIGTVIKLVGFN-IIFISVS---IAIFSSTKFLNKIKLD 402
>UniRef50_A3YI10 Cluster: Major facilitator family transporter; n=1;
Marinomonas sp. MED121|Rep: Major facilitator family
transporter - Marinomonas sp. MED121
Length = 704
Score = 40.7 bits (91), Expect = 0.066
Identities = 41/180 (22%), Positives = 81/180 (45%), Gaps = 11/180 (6%)
Query: 223 LVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYI-NSFYKKDVDY 281
+ GF +G S +Y + ++ + ++ + G + IGY+ + F ++ V
Sbjct: 209 ICGFVLGSLLSMLPVYAGSK-GIAGFNLSLLVGAAIIGGVVLQLPIGYLADRFERRKV-- 265
Query: 282 SLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMV--LKRSDGDHR 339
+ ++ +F ++ +T I+ +++ + LI L+ G VS L L + R +
Sbjct: 266 -MLNIVLFSMVCTLITPYILDFDLFIVSLVLISLSSG-IVSSLYPLGIAETFDRLQQNEM 323
Query: 340 GTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLA--PTVLGLVMSYHYRTKRKV 397
G+ IGA + + G++ P G Q +GV Y + SLA V + Y R +R +
Sbjct: 324 GSAIGAMIIIYASGGIIGPYAVGLVMQHIGVDY-FFTSLAIMQLVFAFFIVYRSRVRRSI 382
>UniRef50_Q2FS41 Cluster: Major facilitator superfamily MFS_1;
n=2; Archaea|Rep: Major facilitator superfamily MFS_1 -
Methanospirillum hungatei (strain JF-1 / DSM 864)
Length = 395
Score = 40.7 bits (91), Expect = 0.066
Identities = 18/53 (33%), Positives = 32/53 (60%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
+L +G++IPL+P +GA+ +G++ S +A + + P G SD+ GRR
Sbjct: 29 MLGIGIVIPLLPRFAETLGASGFGIGMIFSSFALSRAFAMPFFGRYSDICGRR 81
Score = 37.9 bits (84), Expect = 0.46
Identities = 34/159 (21%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 219 LYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKD 278
LY+ + FA G + + +LS G VIS + ++ G + + K
Sbjct: 218 LYQMMNAFANGTFMVFLPVIAAHVGNLSAGETGLVISVSVLSTALLQRVCGRLADRFDKY 277
Query: 279 VDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDH 338
+ + L V + L++ + G +++Y+ + + + +G +S +V
Sbjct: 278 LLIATGCLTVTVALAL-VPGFE---GLWSYLFFALLMGIGGGISVPAMYALVTIAGRDVG 333
Query: 339 RGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYAS 377
+G +G N V S+ +++P+V G G+S V Y S
Sbjct: 334 QGAAMGTINMVMSMGMIISPVVCGLFMDQTGISSVFYLS 372
>UniRef50_Q7U3D8 Cluster: Multidrug efflux transporter, MFS family;
n=17; Cyanobacteria|Rep: Multidrug efflux transporter,
MFS family - Synechococcus sp. (strain WH8102)
Length = 432
Score = 40.3 bits (90), Expect = 0.087
Identities = 39/156 (25%), Positives = 59/156 (37%), Gaps = 17/156 (10%)
Query: 3 DLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXX 62
D L+ + +PL+P + ++ VGLL YA Q PLIG+LSD GR+
Sbjct: 35 DRLSESIFLPLLPFLLADFSSSGSTVGLLSGTYALSQFAVAPLIGALSDRFGRKPVISIC 94
Query: 63 XXXCSVAYTVLGLTXX----------------XXXXXXXXXXXXXXKQTQMLAKALVPDY 106
V + +T T A A++ D
Sbjct: 95 VGGSVVGMGLFAITLTVPWQQIWPGAAAAGVPLALLFTARIIDGISGGTAATATAVLADV 154
Query: 107 ENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDN 142
E + A+ +G + G+G LGP +GG + E N
Sbjct: 155 TTPENR-AKAFGLIGVAFGLGFALGPGLGGVLGEMN 189
>UniRef50_Q03KW0 Cluster: Permease of the major facilitator
superfamily; n=3; Streptococcus thermophilus|Rep:
Permease of the major facilitator superfamily -
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Length = 390
Score = 40.3 bits (90), Expect = 0.087
Identities = 39/188 (20%), Positives = 79/188 (42%), Gaps = 7/188 (3%)
Query: 204 VVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTY-DLSPKYVGYVISFQGVMGS 262
+ L++I SK + L ++ ++GV Y Y + T Y +S + +SF V
Sbjct: 195 ITLFNILRSKKIALVLLSGVIVGSIGVVYDTYEVVYLTKYLGISDSMYSFSLSFLAVSFL 254
Query: 263 ISSYFIGYINSFYKKDVDYSL-RSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAV 321
+ S+ + ++ ++L S +V LL S S N+Y ++ + LA+G +
Sbjct: 255 VMSFLLSFVKQISSHMKAFALGLSFYVLYLLLFS-----TSSNIYTVLMSYVFLAIGQTM 309
Query: 322 SRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPT 381
++ + L S ++ S+ +A +V G +++ SLA
Sbjct: 310 MGIIETNYFQLSLNMKELQKLYIYSETLHSVFSGIAVLVIGSFAFLSSHLVLVFRSLAVF 369
Query: 382 VLGLVMSY 389
L +++ Y
Sbjct: 370 ALFILLCY 377
>UniRef50_UPI0000498C9C Cluster: hypothetical protein 100.t00005;
n=1; Entamoeba histolytica HM-1:IMSS|Rep: hypothetical
protein 100.t00005 - Entamoeba histolytica HM-1:IMSS
Length = 507
Score = 39.9 bits (89), Expect = 0.11
Identities = 45/199 (22%), Positives = 86/199 (43%), Gaps = 20/199 (10%)
Query: 196 FNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYA-------LYLKTTYDLSPK 248
F S + + LY IN DI L+ + G +G+ + Y +L D S
Sbjct: 282 FLSKRPTHYFLYYIN-----DIILHLVIYG-TVGIIQNQYVNLASDKQTHLPGFSDNSDV 335
Query: 249 YVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNY 308
YVG ++ + ++ + +G+ ++ K + ++ SL L+ I LTG + N Y
Sbjct: 336 YVGILLFVINIAQLVAFFILGFFKAWQFK-ITLNIISL---LISMICLTGFLFINN--GY 389
Query: 309 VIWLIPLAMGNAVSRLVTLEMVLKRSDGD-HRGTLIGASNSVRSLSGVVAPMVAGFTGQF 367
++ + G + M + + +G +G S LS ++P++AG
Sbjct: 390 ILCTFGIIFGFIAGFDLEENMFYSLNASEKEKGKYMGISECSSCLSYSLSPLIAGVLSTL 449
Query: 368 LGVSYVIYASLAPTVLGLV 386
L + IY+S+ ++GL+
Sbjct: 450 LTTEWCIYSSMIFVLIGLI 468
>UniRef50_Q3IGF3 Cluster: Putative uncharacterized protein; n=1;
Pseudoalteromonas haloplanktis TAC125|Rep: Putative
uncharacterized protein - Pseudoalteromonas haloplanktis
(strain TAC 125)
Length = 417
Score = 39.9 bits (89), Expect = 0.11
Identities = 25/84 (29%), Positives = 46/84 (54%), Gaps = 3/84 (3%)
Query: 236 ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSL-HVFLLLSI 294
AL+L+T+ +G + F GSI F G IN Y++ L++L +F++ +I
Sbjct: 21 ALFLETSSLFLRLLLGLALGFALAKGSIG--FAGSINRAYRRGSTQLLQTLMFMFVITAI 78
Query: 295 SLTGLIVSINVYNYVIWLIPLAMG 318
GL+V+ + +Y +W+ P+ +G
Sbjct: 79 INAGLLVNTDSTSYNLWVNPINLG 102
>UniRef50_Q41CM9 Cluster: Major facilitator superfamily MFS_1
precursor; n=1; Exiguobacterium sibiricum 255-15|Rep:
Major facilitator superfamily MFS_1 precursor -
Exiguobacterium sibiricum 255-15
Length = 486
Score = 39.9 bits (89), Expect = 0.11
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 5/115 (4%)
Query: 30 LLGSIYAGFQLG---SGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXX 86
L+ I+AGF L S P+ G ++DL GR+ +VA GL
Sbjct: 39 LVSWIFAGFLLFMAVSTPIYGKMADLYGRKRVLLFGIGVFTVASLACGLAQSMEMLILFR 98
Query: 87 XXXXXXKQTQM-LAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIME 140
+ +A ++ D E++ +I G ++A+ G+ GP++GG ++E
Sbjct: 99 AAQGIGAGAVLPIAMTIIGDLYTYEER-GKIQGVLSAVWGISGVAGPLVGGFLVE 152
>UniRef50_A6PC97 Cluster: Drug resistance transporter, Bcr/CflA
subfamily precursor; n=1; Shewanella sediminis
HAW-EB3|Rep: Drug resistance transporter, Bcr/CflA
subfamily precursor - Shewanella sediminis HAW-EB3
Length = 413
Score = 39.9 bits (89), Expect = 0.11
Identities = 58/318 (18%), Positives = 124/318 (38%), Gaps = 21/318 (6%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
LA+ + +P +P + + A H + + +++ + PL G L+D +
Sbjct: 21 LAIDMYLPALPEMAKHLNATHSQMEMSVAVFLLAFAIAQPLFGLLADRYHKLNLLLTGLV 80
Query: 65 XCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAIS 124
+++ + + + ++ A++ + + QK A + + A
Sbjct: 81 IFTLSTLAIPMVDSATGLYLARIFQAIGGASSVVCFAMIQQ-QYDLQKGARVLTYVMAAV 139
Query: 125 GVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXX 184
V L PM+GG I++ + ++F F F A+L+
Sbjct: 140 VVAPLLAPMVGGQILK-YASWQWIFYTLAGIAIFAFVASLLTHAQADKSVQGEEKTEQAN 198
Query: 185 DVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYD 244
+ FKQ + Y + S F + L F G Y +Y+ +
Sbjct: 199 QSRRAASISDFVQIFKQPLPLAYILVGS-----FGFAGLFSFVAGSPY----VYM-NYFS 248
Query: 245 LSPKYVGYVISFQG---VMGSISSY-FIGYINSFYKKDVDYSL---RSLHVFLL--LSIS 295
LSP++ Y++ ++GS+ S +G+I+ K + +L SL F+L + +
Sbjct: 249 LSPEHYSYLLGLNALGMIIGSLLSVKLLGHISPKVKAVISGTLLGPLSLLFFMLAQIEVP 308
Query: 296 LTGLIVSINVYNYVIWLI 313
L ++ ++ ++N ++ LI
Sbjct: 309 LMAIVATVFIFNLLLGLI 326
>UniRef50_UPI00015978DB Cluster: putative permease MDR type; n=1;
Bacillus amyloliquefaciens FZB42|Rep: putative permease
MDR type - Bacillus amyloliquefaciens FZB42
Length = 555
Score = 39.5 bits (88), Expect = 0.15
Identities = 25/69 (36%), Positives = 37/69 (53%), Gaps = 5/69 (7%)
Query: 95 TQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIV 154
T +A A+VP + K+ I G A SG+ TLGP++GG + E+ A FI +
Sbjct: 116 TMPIALAIVP-----QNKKGMIIGIWGAFSGLAATLGPVLGGLLTENFNWQAIFFINIPL 170
Query: 155 GICFIFNAA 163
G+ +F AA
Sbjct: 171 GLISLFLAA 179
>UniRef50_Q6AJB3 Cluster: Related to quinolone resistance protein;
n=2; Deltaproteobacteria|Rep: Related to quinolone
resistance protein - Desulfotalea psychrophila
Length = 403
Score = 39.5 bits (88), Expect = 0.15
Identities = 17/55 (30%), Positives = 35/55 (63%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRR 56
+ LL +G+I+P++P + +GA +G++ + ++ + P+IG+LSD GR+
Sbjct: 15 IALLGIGIIVPVMPIYAETLGAGGFALGMIIASFSVSRCILQPIIGNLSDSLGRK 69
>UniRef50_Q67MU6 Cluster: Putative multidrug efflux protein; n=1;
Symbiobacterium thermophilum|Rep: Putative multidrug
efflux protein - Symbiobacterium thermophilum
Length = 410
Score = 39.5 bits (88), Expect = 0.15
Identities = 31/136 (22%), Positives = 56/136 (41%), Gaps = 5/136 (3%)
Query: 9 LIIPLVPGHVRK---MGAN-HIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXX 64
+++P +P + + +GA ++ GLLG++ +GF + P+ G+L D GR+
Sbjct: 33 MVMPFMPVFLSEDLGVGAGVTVWAGLLGAVNSGFSALTAPIWGALGDRWGRKAMMVRAGI 92
Query: 65 XCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAIS 124
AY ++ A ALV E+ + +A +
Sbjct: 93 FLGSAYVLMAFVRNPYELLGVRVMIGALTGFIPTATALVAT-TTPERHMGQALSLVATGN 151
Query: 125 GVGITLGPMIGGHIME 140
G LGPM+GG + +
Sbjct: 152 QAGSILGPMLGGFLAD 167
>UniRef50_O34307 Cluster: YvmA; n=4; Bacillus|Rep: YvmA - Bacillus
subtilis
Length = 403
Score = 39.5 bits (88), Expect = 0.15
Identities = 34/155 (21%), Positives = 70/155 (45%), Gaps = 4/155 (2%)
Query: 232 YSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLL 291
YS +K ++ +S V +S ++ +I +G I F K L + L
Sbjct: 29 YSPILPIIKESFHVSTAMVNLSVSVFMIVTAIMQIILGAIIDF--KGARIVL--ITGILA 84
Query: 292 LSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRS 351
+ + G V+ + ++I+ + A G+A L+ + + G+ RG+ +G + S
Sbjct: 85 TAAASIGCAVTTDFTLFLIFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLS 144
Query: 352 LSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLV 386
++ +AP++ GF G G + + A +++ LV
Sbjct: 145 VAPAIAPVLGGFIGGAAGYEGIFWILAAISIVLLV 179
>UniRef50_Q034A5 Cluster: Permease of the major facilitator
superfamily; n=2; Lactobacillus|Rep: Permease of the
major facilitator superfamily - Lactobacillus casei
(strain ATCC 334)
Length = 524
Score = 39.5 bits (88), Expect = 0.15
Identities = 29/137 (21%), Positives = 67/137 (48%), Gaps = 4/137 (2%)
Query: 252 YVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIW 311
+V++ ++ ++S + + Y + + L SL +F+L S ++ G+ S+ V +
Sbjct: 55 WVLNAYTLVYAVSLLIMSKLGDMYGRKKVF-LGSLILFVLAS-TVNGMASSLIVLDIGRG 112
Query: 312 LIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVS 371
+ A+G A +++ +V G+ RG +G SV +S P++ GF + G
Sbjct: 113 I--QAIGGAGMNSLSMALVASNFSGNKRGVALGILGSVIGMSTASGPLIGGFLVENFGWP 170
Query: 372 YVIYASLAPTVLGLVMS 388
+ Y ++ ++ ++M+
Sbjct: 171 SIFYVNVPVGIVAVIMT 187
>UniRef50_A0Z910 Cluster: Major facilitator superfamily MFS_1; n=1;
marine gamma proteobacterium HTCC2080|Rep: Major
facilitator superfamily MFS_1 - marine gamma
proteobacterium HTCC2080
Length = 423
Score = 39.5 bits (88), Expect = 0.15
Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 9/116 (7%)
Query: 290 LLLSISLTGLIVSINVYNYV--IWLI--PLAMGNAVSRLVTLEMVLKRSD--GDHRGTLI 343
L+ +I GL ++ ++ +W+ + +G+A+ VT + D H GTL+
Sbjct: 307 LMQTIGFGGLTAALVTVGHLDTVWMAIATMTVGSALGAFVTGGFAVNHMDVAPRHAGTLM 366
Query: 344 GASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLA--PTVLGLVMSYHYRTKRKV 397
G +N+ ++ G++ V G + G S++I SLA T+ GLV + + K+
Sbjct: 367 GITNTAGAIPGIIGVFVTGLILELTG-SWIIVFSLAGGVTLFGLVFYLMFASGEKL 421
>UniRef50_A7RGX9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 470
Score = 39.5 bits (88), Expect = 0.15
Identities = 62/343 (18%), Positives = 132/343 (38%), Gaps = 17/343 (4%)
Query: 26 IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXX 85
++ G++GS+++ Q PLIG+ SDL GRR +Y + ++
Sbjct: 109 LFGGVVGSLFSLLQFICCPLIGAASDLFGRRITLLLSMIGVLFSYVIWAVSKNFTIFVIA 168
Query: 86 XXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNG 145
K + A V D +++ + + + +G +GPMIG +
Sbjct: 169 RVIGGLCKGNVTICTAAVTDVTSSKTRSKGM-ALVGVAYSIGFIVGPMIGAVFASKSSGS 227
Query: 146 AFMFIAFIVGICFIFNAA--LVCFLXXXXXXXXXXXXXXXXDVLSENLV-LSLFNSFKQS 202
+ F + +A ++ FL ++L+ ++ + FK S
Sbjct: 228 SEPFYQLPALFAIVLSAVDIVIVFLFFKETLPTEKRAKSLIHECQKSLLYINPVSLFKFS 287
Query: 203 FVVLYSINWSKYWDIFLYKAL--VGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVM 260
++ S ++ +A+ V F ++S L T+ L+ K Y QG+M
Sbjct: 288 -----ALEGSSDAELQTVRAIGRVYFLFLFFFS--GLEFTLTF-LTHKNFQYTSMNQGMM 339
Query: 261 GSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLI-VSINVYNYVIW--LIPLAM 317
+ + Y + + +++ + G+I V + ++++ L +
Sbjct: 340 FFYVGSVMATVQGGYVRRLPAGAEKKTAVQGIAVIIPGMILVGLAKTTFILYAGLTLFSY 399
Query: 318 GNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMV 360
G+AV ++ + D +G ++G S+ +L+ +AP V
Sbjct: 400 GSAVVVPCLTALISRYGSEDQKGRVMGIFRSLGALARGIAPFV 442
>UniRef50_A2F7Q4 Cluster: Putative uncharacterized protein; n=2;
Eukaryota|Rep: Putative uncharacterized protein -
Trichomonas vaginalis G3
Length = 1356
Score = 39.5 bits (88), Expect = 0.15
Identities = 25/107 (23%), Positives = 51/107 (47%), Gaps = 8/107 (7%)
Query: 219 LYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKD 278
L+ + F V+ + L ++++DL V + S+++ Y+ S +K
Sbjct: 128 LFNLFIAFVHSVFLEPFDLVERSSFDLYDGKNRLVFHIINLFNVFMSFYLPYVTSEVQKC 187
Query: 279 VDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLV 325
+ Y FLLLS+S+ L + + + YV WL+ + NA++ ++
Sbjct: 188 IFY-------FLLLSLSIFDLYIRVLPFTYVSWLVKY-IQNAINFVI 226
>UniRef50_Q81KN5 Cluster: Drug resistance transporter, EmrB/QacA
family; n=11; Bacillus cereus group|Rep: Drug resistance
transporter, EmrB/QacA family - Bacillus anthracis
Length = 478
Score = 39.1 bits (87), Expect = 0.20
Identities = 27/117 (23%), Positives = 50/117 (42%), Gaps = 4/117 (3%)
Query: 28 VGLLGSIYAGFQLG---SGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXX 84
V L+ +YA + L S P+ G L+DL GR+ V + G+
Sbjct: 37 VELVSWVYAIYMLATAVSTPIYGKLADLFGRKKVLLIGATIFLVGSALCGVVTSMEQLIF 96
Query: 85 XXXXXXXXKQTQM-LAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIME 140
M + ++ D + + +A+ G M+A+ GV +GP++GG +++
Sbjct: 97 FRALQGIGAGAVMPITMTIIGDLYSEAKDRAKAQGWMSAVWGVSGVIGPLVGGFLVD 153
>UniRef50_Q2JNV3 Cluster: Transporter, drug:H+ antiporter-1 (12
spanner) (DHA1) family; n=3; Cyanobacteria|Rep:
Transporter, drug:H+ antiporter-1 (12 spanner) (DHA1)
family - Synechococcus sp. (strain JA-2-3B'a(2-13))
(Cyanobacteria bacteriumYellowstone B-Prime)
Length = 433
Score = 39.1 bits (87), Expect = 0.20
Identities = 38/153 (24%), Positives = 65/153 (42%), Gaps = 5/153 (3%)
Query: 10 IIPLVPGHVRKMGANHIYVG-LLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSV 68
++P +P +VR G VG ++G+ G L P +G L+D R+ +
Sbjct: 32 LLPTLPLYVRDAGGTSQQVGWVMGAFSIGL-LAFRPALGRLADGHSRQIVLLIGMGVVGM 90
Query: 69 AYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKA-LVPDYENNEQKQAEIYGKMAAISGVG 127
A L+ A LV D+ E+K+ EI G M+ ++ +G
Sbjct: 91 APIGYWLSDWIPWVALVRAFHGVSIAAFATAYVTLVVDFAP-EEKRGEILGYMSLVNPIG 149
Query: 128 ITLGPMIGGHIMEDNPNG-AFMFIAFIVGICFI 159
+GP +GG + E G +F+F A + + F+
Sbjct: 150 AAIGPALGGFLQEFAGYGPSFLFSALLGLVGFL 182
>UniRef50_A0EFI4 Cluster: Chromosome undetermined scaffold_93, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_93,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 313
Score = 39.1 bits (87), Expect = 0.20
Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 14/99 (14%)
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSF-YKKDVDYSLRSLHVFLLLSISLT 297
+KT Y L+ K+VGY++ +G + +IG I SF Y + Y L + L++ + L
Sbjct: 12 IKTIYSLAFKFVGYLL-----IGFFMALYIGIIYSFIYDTMLLYYLVYNNKLLVVVLMLV 66
Query: 298 GLIVSINV-YNYVIWLIPLAMGNAVSRLVTLEMVLKRSD 335
GLI NV +NY + LI VS +T E+ KR D
Sbjct: 67 GLIEGFNVIFNYGLVLI-------VSPGLTSEIFTKRDD 98
>UniRef50_Q757R9 Cluster: AEL057Cp; n=1; Eremothecium gossypii|Rep:
AEL057Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 557
Score = 39.1 bits (87), Expect = 0.20
Identities = 26/112 (23%), Positives = 44/112 (39%)
Query: 27 YVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXX 86
Y G LGS++A Q+ S G ++ GR+ + +LG
Sbjct: 62 YSGWLGSVFALCQVVSAMNWGHFAERYGRKWALILGQLGTCCSLLLLGFAGNYYQALLAR 121
Query: 87 XXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHI 138
+ + +V + + E+ QA + M + G LGPMIGG++
Sbjct: 122 SLMGLLNGNAGVVRTVVGELASQERHQALAFSTMQLLWQFGAVLGPMIGGYL 173
>UniRef50_A7E4U3 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 596
Score = 39.1 bits (87), Expect = 0.20
Identities = 35/161 (21%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTG 298
+ T +S V ++ ++ ++ F G I+ + + + + F++ S G
Sbjct: 150 ISTDLHVSLSLVSLTVTVYMIVQGLAPSFWGPISDTKGRRITF----MGTFIVYLASNIG 205
Query: 299 LIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAP 358
L +S N ++ A G+A + V + + RG LIG +R L V P
Sbjct: 206 LALSKNFTTLMVLRAIQAAGSAATIAVGAGAIADCTTPKERGGLIGVFGGIRMLGQSVGP 265
Query: 359 MVAGFTGQFLGVSYVIY--ASLAPTVLGLVMSYHYRTKRKV 397
++ G Q+LG + + L L L++++ T R V
Sbjct: 266 VLGGIITQYLGFRAIFWFLLGLGSLALLLIIAFLPETLRSV 306
>UniRef50_Q4JAS6 Cluster: Conserved membrane protein; n=6;
Sulfolobaceae|Rep: Conserved membrane protein -
Sulfolobus acidocaldarius
Length = 384
Score = 39.1 bits (87), Expect = 0.20
Identities = 23/105 (21%), Positives = 52/105 (49%), Gaps = 5/105 (4%)
Query: 284 RSLHVFLLLSISLT-----GLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDH 338
RSL LL+S+ +T G++ S N+ Y+I++ L + + ++ ++ + + +
Sbjct: 263 RSLRYPLLISVVITILGIIGVVFSPNLALYLIFMALLGIPHGSVFPISTIIIARATSSEE 322
Query: 339 RGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVL 383
R + + ++ + P+V G QF+G+ Y A + P ++
Sbjct: 323 RNAVNSYFLAYNNILFFIVPIVVGALSQFIGLGYAFVALIIPVII 367
>UniRef50_Q8ZQ25 Cluster: Multidrug resistance protein mdtG; n=36;
Enterobacteriaceae|Rep: Multidrug resistance protein
mdtG - Salmonella typhimurium
Length = 404
Score = 39.1 bits (87), Expect = 0.20
Identities = 36/160 (22%), Positives = 64/160 (40%), Gaps = 7/160 (4%)
Query: 6 AVGLIIPLVPGHVRKMG-----ANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
A L++P +P +V ++G A +++ GL+ SI F + P G L+D KGR+
Sbjct: 27 AFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLL 86
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
++ ++G+ A AL+ + K G +
Sbjct: 87 RSALGMAIVMLLMGMAQNIWQFLILRALLGLLGGFIPNANALIAT-QVPRHKSGWALGTL 145
Query: 121 AAISGVGITLGPMIGGHIMED-NPNGAFMFIAFIVGICFI 159
+ G LGP+ GG + + F A ++ ICF+
Sbjct: 146 STGGVSGALLGPLAGGLLADHYGLRPVFFITASVLFICFL 185
>UniRef50_Q74FA3 Cluster: Major facilitator family transporter; n=5;
Desulfuromonadales|Rep: Major facilitator family
transporter - Geobacter sulfurreducens
Length = 428
Score = 38.7 bits (86), Expect = 0.27
Identities = 40/155 (25%), Positives = 56/155 (36%), Gaps = 4/155 (2%)
Query: 13 LVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTV 72
+V VR+ G + GL S F SG + G+LSD GRR S AY +
Sbjct: 262 IVTTMVREFGFSEARAGLYWSWAGFFSCFSGVVFGALSDRIGRRHGLALVFAVQSTAYLI 321
Query: 73 LGL-TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLG 131
G + A V DY + A + + VG TLG
Sbjct: 322 AGTKPGGVGLVVSIVLYGLAVFAIPAIMAAAVGDY-LGAPRAAGAFATITIFFAVGQTLG 380
Query: 132 PMIGGHI--MEDNPNGAFMFIAFIVGICFIFNAAL 164
P + G I + +GA++ A I +F L
Sbjct: 381 PALAGMIGKAAGSFSGAYLLAASITVCALLFTLFL 415
>UniRef50_Q3WEI6 Cluster: Drug resistance transporter EmrB/QacA
subfamily; n=7; Bacteria|Rep: Drug resistance
transporter EmrB/QacA subfamily - Frankia sp. EAN1pec
Length = 502
Score = 38.7 bits (86), Expect = 0.27
Identities = 47/210 (22%), Positives = 94/210 (44%), Gaps = 16/210 (7%)
Query: 98 LAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGIC 157
+A +++ + + +++A G A+ G+ + LGP++GG ++E A +I +G+
Sbjct: 119 VAMSIITNTFTDPRERARAIGLWGAVIGISMALGPVLGGILVETVSWRAIFWINIPIGL- 177
Query: 158 FIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINW-SKYWD 216
AALV L D + + LV+++ + S + + W S
Sbjct: 178 ----AALV--LTHRFVPESRAPSPRRLDPVGQLLVIAVLATLTYSIIEAPAAGWTSAETL 231
Query: 217 IFLYKALVGFAMGVYYSNYAL--YLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSF 274
+ L A+ A+ V Y + L + S + G G+++ + ++N+
Sbjct: 232 VLLAVAVAAAALLVGYESRRTEPLLDVRFFRSAPFSGATAIAVCAFGALAGFL--FLNTI 289
Query: 275 YKKDV-DYSLRSLHVFLL-LSISLTGLIVS 302
Y +DV YS +LH LL L ++L L+++
Sbjct: 290 YLQDVRGYS--ALHAGLLTLPMALATLVIA 317
>UniRef50_A3TZ27 Cluster: Drug resistance transporter, EmrB/QacA
family protein; n=3; Rhodobacteraceae|Rep: Drug
resistance transporter, EmrB/QacA family protein -
Oceanicola batsensis HTCC2597
Length = 514
Score = 38.7 bits (86), Expect = 0.27
Identities = 30/139 (21%), Positives = 65/139 (46%), Gaps = 4/139 (2%)
Query: 249 YVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNY 308
Y+ +V++ + ++ + G + Y + + + ++ VFLL + + G+ S+ V
Sbjct: 60 YISWVVTAFLLASTVGAPIAGKLGDMYGRKIVLQV-AIGVFLLGGL-ICGVARSMEVL-- 115
Query: 309 VIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFL 368
+ +G +V++ +V RG + GA +SV S VV P++ GF Q +
Sbjct: 116 IAGRFVQGLGGGALIVVSMAVVADVLPPRERGRVQGALSSVFGFSTVVGPLIGGFLVQTV 175
Query: 369 GVSYVIYASLAPTVLGLVM 387
G ++ + + V+ V+
Sbjct: 176 GWHWIFFVNFPIGVVAFVI 194
>UniRef50_A4HMU9 Cluster: Putative uncharacterized protein; n=3;
Leishmania|Rep: Putative uncharacterized protein -
Leishmania braziliensis
Length = 648
Score = 38.7 bits (86), Expect = 0.27
Identities = 27/110 (24%), Positives = 46/110 (41%), Gaps = 1/110 (0%)
Query: 29 GLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXX 88
GLL SIY Q+ +G L G+ SD GR+ ++ G++
Sbjct: 55 GLLISIYQLGQMLTGKLWGTASDRVGRKPIIQVGLLTNAIVSIFFGMSPSLKLCIITRFI 114
Query: 89 XXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHI 138
++AK ++ D + E + + + GVG +GP +GGH+
Sbjct: 115 QGCANGNVLVAKTVIADITDKE-TEGMGFAAINIFWGVGSVVGPALGGHL 163
>UniRef50_Q59T81 Cluster: Potential transmembrane protein; n=2;
Saccharomycetales|Rep: Potential transmembrane protein -
Candida albicans (Yeast)
Length = 633
Score = 38.7 bits (86), Expect = 0.27
Identities = 36/128 (28%), Positives = 65/128 (50%), Gaps = 17/128 (13%)
Query: 250 VGYVISFQGVMGSISSYFI-GYINSFYKKDVDYSLRSLHV-FLLLSISLTGLIVSINVYN 307
+G ++SF G++G++S F+ +++ Y+ SLR+ + F +L L L+ + +VYN
Sbjct: 461 IGNLLSFTGLIGTLSVMFVFPFLDRHYRPIT--SLRASQIIFPILYPVLPYLVFTHHVYN 518
Query: 308 ------------YVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGV 355
YV+ I L NAV + ++ + S HR + G S S+ SL+
Sbjct: 519 NANPPWLTKTLLYVLCCI-LTASNAVGFPNIIVLIHRSSPEQHRAFINGTSLSLNSLARF 577
Query: 356 VAPMVAGF 363
+ PM+ G+
Sbjct: 578 LGPMLWGY 585
>UniRef50_Q0W6E0 Cluster: Putative permease; n=1; uncultured
methanogenic archaeon RC-I|Rep: Putative permease -
Uncultured methanogenic archaeon RC-I
Length = 403
Score = 38.7 bits (86), Expect = 0.27
Identities = 55/288 (19%), Positives = 116/288 (40%), Gaps = 26/288 (9%)
Query: 110 EQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLX 169
++ + + G +I G G LGP+ GG I++ + MF +C ALVC L
Sbjct: 131 KEGKGKAMGTYNSIKGAGYALGPIAGGLIIQYFRDFNMMF-----WLCT--GVALVCLLL 183
Query: 170 XXXXXXXXXXXXXXXDVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMG 229
V ++ + ++ Y I + + ++ +++ F +
Sbjct: 184 SFAFVRESYNPKEHKRVPVAEMIRE---GSQSDYLACYFIGMT---GMLVFYSIISF-LP 236
Query: 230 VYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVF 289
+Y + TT G ++ Q V+ ++ Y+ G Y + + S V
Sbjct: 237 MYGLQNQIDTGTT--------GLILGVQAVIYVLAQYYCGKAADKYGSRLPLMVGS--VL 286
Query: 290 LLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSV 349
L +++ + L+ S ++ + L +G A +V+ + + GT++G S +
Sbjct: 287 LTVALLMIALVPSAPIWFAAVVLS--GIGIASLWVVSNSYLAYIAPAAIMGTVMGLSGTF 344
Query: 350 RSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTKRKV 397
+ L P++ GF G+ A + T++ ++S R++R+V
Sbjct: 345 KELGDGGGPILVGFLSDIWGLKAAFIACVGFTLVSFLLSLRIRSERRV 392
>UniRef50_Q5YZV3 Cluster: Putative transporter; n=1; Nocardia
farcinica|Rep: Putative transporter - Nocardia farcinica
Length = 526
Score = 38.3 bits (85), Expect = 0.35
Identities = 39/167 (23%), Positives = 67/167 (40%), Gaps = 7/167 (4%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXX 61
+D + V L +P + VR++G++ + + YA GSL D GRR
Sbjct: 25 MDAMIVNLALPSL---VRELGSSTTGLQWIIDAYALTFAALVLAAGSLGDRFGRRNTLLL 81
Query: 62 XXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKAL--VPDYENNEQKQAEIYGK 119
+VA T LG + L + + ++A G
Sbjct: 82 GLVIFTVA-TGLGALCTSTGQLIAARTVMGLGAALIFPSTLSILTNVFVERTERAAAIGV 140
Query: 120 MAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVG-ICFIFNAALV 165
A+SG+G+ LGP++GG ++E G+ + VG +C + +V
Sbjct: 141 WGAVSGIGVVLGPIVGGLLLEYFWWGSVFVVVVPVGLVCLVLTVLVV 187
>UniRef50_Q39FZ4 Cluster: Major facilitator superfamily (MFS_1)
transporter; n=52; Bacteria|Rep: Major facilitator
superfamily (MFS_1) transporter - Burkholderia sp.
(strain 383) (Burkholderia cepacia (strain ATCC 17760/
NCIB 9086 / R18194))
Length = 426
Score = 38.3 bits (85), Expect = 0.35
Identities = 23/76 (30%), Positives = 38/76 (50%), Gaps = 8/76 (10%)
Query: 202 SFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVG----YVISFQ 257
+F Y++ S +W + + G AM Y+ Y + +L PK V +I+
Sbjct: 310 AFAASYALGSSHFWISYALLVVAGAAM---YAPYGPFFAIVSELLPKNVAGGAMALINSM 366
Query: 258 GVMGS-ISSYFIGYIN 272
G +GS + SYF+GY+N
Sbjct: 367 GALGSFVGSYFVGYLN 382
>UniRef50_Q143W2 Cluster: Major facilitator superfamily (MFS)
metabolite/H+ symporter; n=1; Burkholderia xenovorans
LB400|Rep: Major facilitator superfamily (MFS)
metabolite/H+ symporter - Burkholderia xenovorans
(strain LB400)
Length = 448
Score = 38.3 bits (85), Expect = 0.35
Identities = 28/93 (30%), Positives = 44/93 (47%), Gaps = 3/93 (3%)
Query: 284 RSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVT---LEMVLKRSDGDHRG 340
R H+ +LL ++ GL++S V + ++ LI +AMG A + T M G
Sbjct: 314 RRWHMLVLLGLAGIGLLMSAAVASPILALIGIAMGAAGMQAATPLFWTMPSTVFRGAMAA 373
Query: 341 TLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYV 373
+ NS+ +LSG+ P + GF G S V
Sbjct: 374 VALAMVNSLGNLSGLAGPWILGFFSDVTGSSRV 406
>UniRef50_A6SYA1 Cluster: Transporter of the MFS superfamily; n=3;
Bacteria|Rep: Transporter of the MFS superfamily -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 537
Score = 38.3 bits (85), Expect = 0.35
Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 6/163 (3%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGANHIYV-GLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXX 60
+DL + L +P + ++ +++ G + AGF + +G+L D GRR
Sbjct: 60 LDLTLLHLTLPALAVDLQPTSTQALWIMDAYGFLIAGFLI----TMGTLGDRIGRRKLLL 115
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAK-ALVPDYENNEQKQAEIYGK 119
+ A V + T M + AL+ + ++A G
Sbjct: 116 IGATAFAAASAVAAFSTSPNMLIAARAALGVAGATLMPSTLALISNLFTAPAQRALGIGI 175
Query: 120 MAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNA 162
AA+ G+G LGP++GG ++E GA IA V I + A
Sbjct: 176 WAAMWGIGYALGPVVGGMLLEWFWWGAAFLIAVPVVILLLILA 218
>UniRef50_A5US69 Cluster: Major facilitator superfamily MFS_1
precursor; n=4; Chloroflexaceae|Rep: Major facilitator
superfamily MFS_1 precursor - Roseiflexus sp. RS-1
Length = 407
Score = 38.3 bits (85), Expect = 0.35
Identities = 39/172 (22%), Positives = 63/172 (36%), Gaps = 9/172 (5%)
Query: 1 MVDLLAVGLIIPLVPGHVRKMGAN-----HIYVGLLGSIYAGFQLGSGPLIGSLSDLKGR 55
+V + G+ P +P +V ++G N + G++ S A S P+ GSL+D GR
Sbjct: 16 LVSAVGFGMFFPFLPLYVERLGTNTGFSLEFWAGMVFSGQALTMAISSPIWGSLADRFGR 75
Query: 56 RXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAE 115
+ +V ++G T AL E +
Sbjct: 76 KAMIERAMYGGAVIILLMGFARSAEELALLRAIQGAITGTIAAINALTASLVPRE-RVGY 134
Query: 116 IYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCF 167
G + GI GPM+GG ++ D FI + I I + +V F
Sbjct: 135 AMGMLQVGLWAGIAAGPMLGG-VVADLLGFRAAFI--VTAILLIISGIVVTF 183
>UniRef50_A3XKG1 Cluster: Multidrug-efflux transporter; n=2;
Flavobacteriaceae|Rep: Multidrug-efflux transporter -
Leeuwenhoekiella blandensis MED217
Length = 405
Score = 38.3 bits (85), Expect = 0.35
Identities = 33/150 (22%), Positives = 61/150 (40%), Gaps = 10/150 (6%)
Query: 2 VDLLAVGLIIPLVPGHVRKMGAN--------HIYVGLLGSIYAGFQLGSGPLIGSLSDLK 53
V +L G+++P +P + ++ + ++GLL SIY FQL + G LSD
Sbjct: 19 VVMLGYGILLPTLPYYTERLALKDNLDTDLINFHIGLLTSIYPLFQLIFVIVWGKLSDRY 78
Query: 54 GRRXXXXXXXXXCSVAYTVLGL-TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQK 112
GR+ + + GL T ++ A + D +E++
Sbjct: 79 GRKPVIIIGLIGFVIMQLLTGLATSLTMLYIARIFGGVFTSSVIPVSNAYLSDI-TSEKR 137
Query: 113 QAEIYGKMAAISGVGITLGPMIGGHIMEDN 142
+ +I G+ GP+IGG + + +
Sbjct: 138 RTKIMAWSGVAISSGVIFGPVIGGFLSQSD 167
>UniRef50_Q97WR9 Cluster: Multidrug resistance protein; n=6;
Sulfolobaceae|Rep: Multidrug resistance protein -
Sulfolobus solfataricus
Length = 472
Score = 38.3 bits (85), Expect = 0.35
Identities = 34/155 (21%), Positives = 59/155 (38%), Gaps = 1/155 (0%)
Query: 9 LIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSV 68
++IP +P + V + S Y + PL G L D G++ S+
Sbjct: 26 MVIPALPKIETQFSTTATTVAWITSAYLIVGAIASPLFGKLGDRYGKKKVYLLSIGFYSL 85
Query: 69 AYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGI 128
A + G + T LA A++ D E + A G ++A G
Sbjct: 86 AVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAIITDLFPKE-RVAWAQGILSATLAAGP 144
Query: 129 TLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAA 163
LG ++G +I++D AF++ I + +A
Sbjct: 145 ALGLLVGSYIVQDLGWPYAFHTAFLLSIILVIISA 179
>UniRef50_Q649G3 Cluster: Multidrug efflux transporter; n=1;
uncultured archaeon GZfos35A2|Rep: Multidrug efflux
transporter - uncultured archaeon GZfos35A2
Length = 243
Score = 38.3 bits (85), Expect = 0.35
Identities = 32/134 (23%), Positives = 56/134 (41%), Gaps = 2/134 (1%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
+L + +I PL+P + +++G++ S YA + P++G LSD GR+
Sbjct: 21 ILGLSIISPLLPTIAEDLRVTGVWMGMIFSGYAISRAIIMPVMGGLSDKYGRKIFIASGL 80
Query: 64 XXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYE-NNEQKQAEIYGKMAA 122
+V ++L L ++ A+ E E K+ G +
Sbjct: 81 LLLAVI-SLLYLLAHNVYTLTAVRLLNGLAAGMIIPVAMAYAGEVAQEGKEGRAMGIITM 139
Query: 123 ISGVGITLGPMIGG 136
I +GI +GP IGG
Sbjct: 140 IFYLGIAVGPFIGG 153
>UniRef50_Q664N1 Cluster: Protein tsgA homolog; n=45;
Gammaproteobacteria|Rep: Protein tsgA homolog - Yersinia
pseudotuberculosis
Length = 394
Score = 38.3 bits (85), Expect = 0.35
Identities = 37/177 (20%), Positives = 79/177 (44%), Gaps = 9/177 (5%)
Query: 209 INWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFI 268
+ W Y L ALV G+ N A Y ++L + +F G + S F+
Sbjct: 9 LTWISYLSYALTGALV-IVTGIVMGNIAEY----FNLPIASMSNTFTFLNA-GILISIFL 62
Query: 269 GYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLE 328
N++ + + + + F+L+ I++ GL+V N+ + I + + + ++ +
Sbjct: 63 ---NAWLMEIIPLKRQLVFGFILMLIAIAGLMVGHNLMIFSISMFIFGVVSGITMSIGTF 119
Query: 329 MVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGL 385
+V +G RG+ + ++S S++G++ P+ A Y +YA + +G+
Sbjct: 120 LVTHMYEGRQRGSRLLFTDSFFSMAGMIFPIAAAMLLARHIEWYWVYACIGLLYVGI 176
>UniRef50_UPI0000E46651 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 326
Score = 37.9 bits (84), Expect = 0.46
Identities = 42/194 (21%), Positives = 81/194 (41%), Gaps = 13/194 (6%)
Query: 208 SINWSKYWDIFLYK--ALVGFAMGVY-YSNYA---LYLKTTYDLSPKYVGYVISFQGVMG 261
++ W K W + + K A+ F + + Y + LYL S G + + G
Sbjct: 125 TLPWIKLWALPMVKEAAIATFCIKIVRYCMFMWLPLYLHQELHYSQTEAGLHSTIFEIGG 184
Query: 262 SISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSIN---VYNYVIWLIPLAMG 318
I S +GY+ + + D + SL + LL ++S G + N L+ A
Sbjct: 185 VIGSASMGYLITRFLHDKAFKGTSLGI-LLSALSFIGFYATTGHGVFLNQSFMLLAGAFN 243
Query: 319 NAVSRLVT--LEMVLKRSDG-DHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIY 375
V ++T + L G D + ++ G N + ++ ++ + G + G +IY
Sbjct: 244 CGVDPILTGSIPSALGEQGGMDIQASVAGFVNGIGTMGTIIEGPIIGLVAELFGWQSMIY 303
Query: 376 ASLAPTVLGLVMSY 389
+A ++LG + +Y
Sbjct: 304 LMIAVSLLGAMATY 317
>UniRef50_Q74KS3 Cluster: Major facilitator superfamily permease;
n=5; Lactobacillus|Rep: Major facilitator superfamily
permease - Lactobacillus johnsonii
Length = 485
Score = 37.9 bits (84), Expect = 0.46
Identities = 33/152 (21%), Positives = 77/152 (50%), Gaps = 8/152 (5%)
Query: 250 VGYVISFQGVMGSISSYFIGYI-NSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNY 308
+ +V+S +M ++S+ G + +S +K V L + VF++ S +L G ++ N+
Sbjct: 45 MNWVVSIFLLMTAVSTPIYGKLADSLGRKPV--FLFGIAVFVIGS-ALCG--IAQNMVEL 99
Query: 309 VIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFL 368
+++ + +G+ + V + ++ + R ++G ++ ++ V+AP++ GF Q L
Sbjct: 100 ILFRVIQGLGSGAVQPVAVTIIADLYTLEKRAKMLGLNSGFWGVASVIAPLLGGFIVQHL 159
Query: 369 GVSYVIYASLAPTVLG--LVMSYHYRTKRKVD 398
++ Y ++ +L LV+ + TK D
Sbjct: 160 SWHWIFYINVPLGILAFLLVIIFLKETKTSKD 191
>UniRef50_Q63RQ1 Cluster: MFS-family transport protein; n=28;
Burkholderia|Rep: MFS-family transport protein -
Burkholderia pseudomallei (Pseudomonas pseudomallei)
Length = 411
Score = 37.9 bits (84), Expect = 0.46
Identities = 38/158 (24%), Positives = 59/158 (37%), Gaps = 9/158 (5%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVG-LLGSIYAGFQLGSGPLIGSLSDLKGRR---XXXX 60
+A + +P +P G L S AGF +G L G LSD GRR
Sbjct: 26 IATDMYLPSLPAIAGGFGVTAAAAQRTLTSFMAGFSIGM-LLYGPLSDTYGRRPVLLGGI 84
Query: 61 XXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKM 120
SV V G +LA+A+ D + A++ +
Sbjct: 85 ALFTLASVGCFVAGSIDMLIAVRFLQAFGAGA--ASVLARAIARD-AHEPADAAKVLSMV 141
Query: 121 AAISGVGITLGPMIGGHIME-DNPNGAFMFIAFIVGIC 157
A ++ +G L P+IGG ++ G F+ +A +C
Sbjct: 142 AIVTAIGPLLAPLIGGQVLRFSGWRGVFVVLALFGAVC 179
>UniRef50_Q47P56 Cluster: Drug resistance transporter Bcr/CflA
subfamily precursor; n=1; Thermobifida fusca YX|Rep:
Drug resistance transporter Bcr/CflA subfamily precursor
- Thermobifida fusca (strain YX)
Length = 440
Score = 37.9 bits (84), Expect = 0.46
Identities = 35/163 (21%), Positives = 68/163 (41%), Gaps = 7/163 (4%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGL-LGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
LA L +P P +GA V L L +I G +G ++G LSD GRR
Sbjct: 55 LATDLYLPAFPEIAADLGATESQVQLTLTAIMVGLAVGQ-LVLGPLSDRWGRRLPLLIGA 113
Query: 64 XXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQT-QMLAKALVPDYENNEQKQAEIYGKMAA 122
+++ + ++++A+V D + E A + +++
Sbjct: 114 AVFTLSSLASAVAPSTEVLSALRLLQGFSAAAGAVISRAVVRDIFHGEDS-ARFFSRLSL 172
Query: 123 ISGVGITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALV 165
++GV + PM+GG ++ G++ + ++ + + N LV
Sbjct: 173 LTGVAPMVAPMLGGQLL---LAGSWRLLFVVLALIGVANLVLV 212
>UniRef50_Q2RZH2 Cluster: Permease, major facilitator superfamily,
putative; n=4; cellular organisms|Rep: Permease, major
facilitator superfamily, putative - Salinibacter ruber
(strain DSM 13855)
Length = 398
Score = 37.9 bits (84), Expect = 0.46
Identities = 32/136 (23%), Positives = 66/136 (48%), Gaps = 6/136 (4%)
Query: 258 GVMG-SISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVY--NYVIWLIP 314
G +G +++ ++GY S + + +L+++ T + ++ + +Y ++L+
Sbjct: 44 GAIGLALTGMWLGYALSQFPSGLLADRYGERGIILVAVGGTAVASTLLAFASSYAMFLVG 103
Query: 315 LAMGNAVSRL-VTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYV 373
A+ V+ L ++ L D GT IG + ++GV+APM AG G ++G +
Sbjct: 104 TAVLGTVAGLHYSVATSLLTRTTDQIGTAIGIHTAGAPVAGVLAPMAAGAVGAWMGWRWA 163
Query: 374 IYAS--LAPTVLGLVM 387
+ A V+GLV+
Sbjct: 164 VALGTVFAAPVVGLVV 179
>UniRef50_Q0SEY0 Cluster: Anion cation symporter, MFS family
protein; n=1; Rhodococcus sp. RHA1|Rep: Anion cation
symporter, MFS family protein - Rhodococcus sp. (strain
RHA1)
Length = 450
Score = 37.9 bits (84), Expect = 0.46
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 9/172 (5%)
Query: 207 YSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSY 266
Y + K W + L A +A V + YL+ + ++ G ++ I+ +
Sbjct: 244 YLLRRRKTWGLALGYASYTYAYYVLLTWLPAYLEKQFGVNLLKGGIYTMIPWLVAVIAQF 303
Query: 267 FIGYI--NSFYKK--DVDYSLRS-LHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAV 321
I I + + + DV R+ L V LL S+++TG + ++ +I+L A G AV
Sbjct: 304 LIAGILMDRWLARTGDVTKVRRTVLVVSLLASLAVTGAAYAGSIAVALIFLSIGAAGLAV 363
Query: 322 SRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGF----TGQFLG 369
S +V + + G+L G N V +L G+ AP+V G TG F G
Sbjct: 364 SVPAGSSIVALIAPQGYTGSLGGIVNFVANLLGIAAPIVTGMVVDSTGSFAG 415
>UniRef50_A6LQ19 Cluster: Drug resistance transporter, EmrB/QacA
subfamily precursor; n=1; Clostridium beijerinckii NCIMB
8052|Rep: Drug resistance transporter, EmrB/QacA
subfamily precursor - Clostridium beijerinckii NCIMB
8052
Length = 483
Score = 37.9 bits (84), Expect = 0.46
Identities = 35/183 (19%), Positives = 78/183 (42%), Gaps = 10/183 (5%)
Query: 223 LVGFAMGVYYSNY-ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFI---GYINSFYKKD 278
L+ A+G + S + + + KY I+F V I++Y + + +F K
Sbjct: 13 LLALAIGTFMSALDSSVVSIVIPVIQKYFNVNIAF--VEWVITAYLLVVSSVLLTFGKLS 70
Query: 279 VDYSLRSLHVFLLLSISLTGLI--VSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDG 336
Y + +++ + +L + +S+N+ +++ I A+G + + ++
Sbjct: 71 DLYGHKKIYLMGFTAFTLGSFLCGISLNIQMLIVFRIFQALGAGMMFSTSSAIITASVPS 130
Query: 337 DHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHY--RTK 394
+ RG G S + P++ G +G + Y ++ +LG+ +SY Y K
Sbjct: 131 NKRGKSFGIIAIAISAACCAGPVIGGILASMMGWQSIFYINIPIGILGIYLSYRYIPEDK 190
Query: 395 RKV 397
+K+
Sbjct: 191 KKI 193
>UniRef50_A5D4M5 Cluster: Arabinose efflux permease; n=1;
Pelotomaculum thermopropionicum SI|Rep: Arabinose efflux
permease - Pelotomaculum thermopropionicum SI
Length = 369
Score = 37.9 bits (84), Expect = 0.46
Identities = 21/77 (27%), Positives = 39/77 (50%)
Query: 312 LIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVS 371
++ + +G A S L +++ G+ RGT G S +L V P++ G Q G
Sbjct: 283 IVQVLLGVAWSCLYVGALLIVLRSGEERGTAGGVFQSTLNLCNAVGPLLGGLIAQGFGYR 342
Query: 372 YVIYASLAPTVLGLVMS 388
V++ + A VLG++++
Sbjct: 343 GVMFFAAALGVLGMLVA 359
>UniRef50_A4J280 Cluster: Major facilitator superfamily MFS_1; n=1;
Desulfotomaculum reducens MI-1|Rep: Major facilitator
superfamily MFS_1 - Desulfotomaculum reducens MI-1
Length = 397
Score = 37.9 bits (84), Expect = 0.46
Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 110 EQKQAEIYGKMAAISGVGITLGPMIGGHIMED-NPNGAFMFIAFIVGICFIF 160
E++QA +G + G+GI GP +GG I +P GA AFI+ IF
Sbjct: 327 EEQQATGWGIFTTLEGLGIAAGPTLGGAIATSLHPAGAIYMSAFILAFMGIF 378
>UniRef50_A4BAS3 Cluster: Putative uncharacterized protein; n=1;
Reinekea sp. MED297|Rep: Putative uncharacterized
protein - Reinekea sp. MED297
Length = 392
Score = 37.9 bits (84), Expect = 0.46
Identities = 35/147 (23%), Positives = 64/147 (43%), Gaps = 9/147 (6%)
Query: 250 VGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSIS-LTGLIVSINVYNY 308
+GY+++ G G I Y GY++ D + + V L +SIS L G+ S ++Y
Sbjct: 42 IGYILTAYGFGGFIGGYLGGYLS-----DKTSPFQVIIVSLTISISALVGIFFSESLYLL 96
Query: 309 VIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLS-GVVAPMVAGFTGQF 367
L+ + R +++ + + R + G N+V ++S G+ A AG
Sbjct: 97 SFLLLTFGFSDHAFRPAFTMLLVNNTSEEKRTYVFGIRNAVMNISIGISA--AAGAAVFD 154
Query: 368 LGVSYVIYASLAPTVLGLVMSYHYRTK 394
L V Y+ V+ L++ + K
Sbjct: 155 LNVKYIFLFDAFLNVITLILLLSFSPK 181
>UniRef50_A3JJB0 Cluster: Transport protein; n=2; Marinobacter|Rep:
Transport protein - Marinobacter sp. ELB17
Length = 398
Score = 37.9 bits (84), Expect = 0.46
Identities = 25/103 (24%), Positives = 50/103 (48%), Gaps = 2/103 (1%)
Query: 289 FLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNS 348
FLL+++S G S ++ +W I + +G + V + + + D G GA +S
Sbjct: 280 FLLMALSYAGQAWSGSLIGLALWRIVMGVGMTLGFFVLHGWIAQLTRTDCAGRTFGALDS 339
Query: 349 VRSLSGVVAPMVAGFTGQFLGVSYVIY--ASLAPTVLGLVMSY 389
+ +GV A + AG G+S ++ A++ L L++++
Sbjct: 340 IGKWAGVAAGLAAGVLSGPAGLSAPLWMGATVLLVTLPLILTF 382
>UniRef50_A2U870 Cluster: Drug resistance transporter, EmrB/QacA
subfamily; n=1; Bacillus coagulans 36D1|Rep: Drug
resistance transporter, EmrB/QacA subfamily - Bacillus
coagulans 36D1
Length = 429
Score = 37.9 bits (84), Expect = 0.46
Identities = 22/111 (19%), Positives = 52/111 (46%), Gaps = 2/111 (1%)
Query: 281 YSLRSLHVFLLLSISLTGLI--VSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDH 338
+ +R L ++ +++ L+ +S + +++ +G A+ T+ +++ +
Sbjct: 17 FGIRQLFSIGIVLFTISSLLCGLSTSPLELIVFRAIEGLGAALLLPQTMTFIIRLFPSER 76
Query: 339 RGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSY 389
RGT +G V ++ V P + GF LG ++ Y ++ VL + +Y
Sbjct: 77 RGTALGIWGMVGGVAAVAGPSLGGFIVSVLGWRWIFYINVPIGVLIFIFTY 127
>UniRef50_A6RK53 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 595
Score = 37.9 bits (84), Expect = 0.46
Identities = 31/149 (20%), Positives = 63/149 (42%), Gaps = 4/149 (2%)
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTG 298
+ T ++S V ++ ++ ++ F G I+ + + + + F++ S G
Sbjct: 151 ISTDLNVSLSLVSLTVTVYMIVQGLAPSFWGPISDTKGRRITF----MGTFIVYLASNIG 206
Query: 299 LIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAP 358
L +S N +++ A G+A + V ++ + RG LIG +R L V P
Sbjct: 207 LALSDNFATLMVFRAIQAAGSAATIAVGAGVIGDITTPKERGGLIGIFGGIRMLGQSVGP 266
Query: 359 MVAGFTGQFLGVSYVIYASLAPTVLGLVM 387
+ G Q+LG + + L L++
Sbjct: 267 VFGGIITQYLGYRAIFWFLFGLGALALLL 295
>UniRef50_O28944 Cluster: Multidrug resistance protein; n=1;
Archaeoglobus fulgidus|Rep: Multidrug resistance protein
- Archaeoglobus fulgidus
Length = 371
Score = 37.9 bits (84), Expect = 0.46
Identities = 29/137 (21%), Positives = 54/137 (39%), Gaps = 4/137 (2%)
Query: 6 AVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXX 65
++ +IP++P + +GA+ ++A F + G LS++ GRR
Sbjct: 14 SLSCVIPIIPSYASSLGASVFLSAFAAGVFALFPAIAMTPFGMLSEVYGRRRFLVAGAVT 73
Query: 66 CSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQML--AKALVPDYENNEQKQAEIYGKMAAI 123
S+ ++L L + ALV D + E ++ E GK+
Sbjct: 74 -SLLASLLYLQSSTAELLVFSRTLHGLGSALYIPSINALVADI-SEESRRGEAMGKLQTA 131
Query: 124 SGVGITLGPMIGGHIME 140
+G GP+ GG + +
Sbjct: 132 LMLGFFAGPLAGGFVSD 148
>UniRef50_A7I7E2 Cluster: Major facilitator superfamily MFS_1; n=1;
Candidatus Methanoregula boonei 6A8|Rep: Major
facilitator superfamily MFS_1 - Methanoregula boonei
(strain 6A8)
Length = 407
Score = 37.9 bits (84), Expect = 0.46
Identities = 71/354 (20%), Positives = 139/354 (39%), Gaps = 25/354 (7%)
Query: 12 PLVPGHVRKMGANHIYVGLLGSI--YAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVA 69
P++P V+ +GA +G++ ++ AG L S P +G LSD GRR +A
Sbjct: 38 PVLPLFVQSLGAGPALLGVIAAVSPLAGV-LFSFP-VGVLSDHLGRRRLLVISAFVFLIA 95
Query: 70 YTV-LGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGI 128
+ L +T + A++ E + E G A+ + VG
Sbjct: 96 PILYLFITDPVWLVPVRFFHGTATAILGPVVSAIIA--ERFPDSRGEKLGTYASATLVGR 153
Query: 129 TLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLS 188
TL P+ GG I+ AF+F ++ ++ A + L VL
Sbjct: 154 TLAPLAGGIIIT-----AFLFAPGLLAYRMVYICAALSALPVFVLILRYREAEAGSLVLP 208
Query: 189 ENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPK 248
+ ++ +FV + + D+ Y FA GV+ + LYL + +
Sbjct: 209 G---IGVYKESLATFVTNRRLRATAMADMASY-----FAYGVFETFLPLYL-ASLSFAAY 259
Query: 249 YVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNY 308
G + + Q ++ + + G ++ +D ++ + L+ I++ + V+ +
Sbjct: 260 QTGIIFAVQVLIIAGTKPVFGRLSD----RIDRRIQIVTGLLVTGIAIAAVPVASTFPGF 315
Query: 309 VIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG 362
+ +G AVS + T V + + G+ +GA +S+ + P++ G
Sbjct: 316 LAASALFGLGIAVSTVATSAYVADVAKQEQIGSSMGALSSIMDIGQSSGPLITG 369
>UniRef50_A2SRE0 Cluster: Major facilitator superfamily MFS_1; n=2;
Methanomicrobiales|Rep: Major facilitator superfamily
MFS_1 - Methanocorpusculum labreanum (strain ATCC 43576
/ DSM 4855 / Z)
Length = 406
Score = 37.9 bits (84), Expect = 0.46
Identities = 40/155 (25%), Positives = 72/155 (46%), Gaps = 13/155 (8%)
Query: 245 LSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSIN 304
LS G V++ V+ S++ FIG D + + + V + I G+ +S+
Sbjct: 51 LSYFLAGLVVTVFNVVSSVTQPFIGLYG-------DRTGKWVSVPFCVLIGSVGISLSVL 103
Query: 305 VYNYVIWLIPL---AMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVA 361
NY+I L + A+G+A+ + +V K S +G + S+S + PM+A
Sbjct: 104 ANNYLIVLFLVGGAAVGHALFHPSAMALVHKLSPPAKKGLYNSIFTTSGSISYSLGPMIA 163
Query: 362 GFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTKRK 396
GF F G+ V + + P ++G ++ YR R+
Sbjct: 164 GFFITFGGLPSVAW-MMVPGIVG--AAWIYRNDRR 195
>UniRef50_A0RU05 Cluster: Permease of the major facilitator
superfamily; n=2; Thermoprotei|Rep: Permease of the
major facilitator superfamily - Cenarchaeum symbiosum
Length = 418
Score = 37.9 bits (84), Expect = 0.46
Identities = 49/270 (18%), Positives = 107/270 (39%), Gaps = 19/270 (7%)
Query: 127 GITLGPMIGGHIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDV 186
G+T+GP++G ++E N + A F+ AA++ +
Sbjct: 140 GVTMGPLLGSVLLE---NVDVTYRALFQITAFVLAAAIIASISLSRRHARDSATGLATPA 196
Query: 187 LSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLS 246
S ++ F + +++ ++ L + GV + + YL L+
Sbjct: 197 ASVSI-------HTPHFTLSAVKAMARFPEVILVLVYCTASFGVILAIFPAYLDDNL-LT 248
Query: 247 PKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGL--IVSIN 304
+G + G+ + +G + + ++L + V L++ + L + I
Sbjct: 249 GTEIGILYFVFGLSRITALIMVGRL----ARRTGHTLVASTVSLVIGLGLAYVAGITGGG 304
Query: 305 VYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFT 364
++ + L+ + G +V + LE+VL R+ G++IGA + + V P++ G
Sbjct: 305 LFLFAASLLIMGFGFSVLFPLALEVVLSRTHKKITGSMIGAYETTIGIGWVTGPIIVGVI 364
Query: 365 GQFLG--VSYVIYASLAPTVLGLVMSYHYR 392
+F G + Y++ L V L + +R
Sbjct: 365 SEFYGGDLPYLVLCILGAGVAVLSAARRHR 394
>UniRef50_O06473 Cluster: Multidrug efflux protein yfmO; n=19;
Bacteria|Rep: Multidrug efflux protein yfmO - Bacillus
subtilis
Length = 396
Score = 37.9 bits (84), Expect = 0.46
Identities = 36/161 (22%), Positives = 71/161 (44%), Gaps = 16/161 (9%)
Query: 220 YKALVGFAMGVYYSNYALYLKTTY-----DLSPKYVGYVISFQGVMGSISSYFIGYINSF 274
YK L+ A+ + N+ ++ Y DL +GYV G++ +I+S F +
Sbjct: 212 YKGLLTMAVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPL--- 268
Query: 275 YKKDVDYSLRSLHVFLLLSISLTGLIVSINVY--NYVIWLIPLAMGNAVSRLVTLEMV-- 330
V +L ++ ++L I+ ++V + ++ + + + + + AV +V M
Sbjct: 269 ----VHKALGTVRSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTA 324
Query: 331 LKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVS 371
+ S R A +SVR + G +AP +AG + S
Sbjct: 325 VMGSAPVERSIASSAYSSVRFIGGALAPWIAGMLSEHFTAS 365
>UniRef50_Q1EUU6 Cluster: Major facilitator superfamily MFS_1; n=1;
Clostridium oremlandii OhILAs|Rep: Major facilitator
superfamily MFS_1 - Clostridium oremlandii OhILAs
Length = 386
Score = 37.5 bits (83), Expect = 0.61
Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 5/87 (5%)
Query: 211 WSKYWDIFLYKALVGFAMGVYY-SNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIG 269
+S W IFL +L GF + Y + +AL LK + K +G VI+ + I + IG
Sbjct: 291 FSNQW-IFLI-SLSGFFFSIIYPTTFALLLKVFGKEAGKVMGVVITISSGLNMIGNAIIG 348
Query: 270 YINSFYKKDVDYSLRSLHVFLLLSISL 296
+N +++ R + V+LL+SI L
Sbjct: 349 QMNDII--GLEFGFRLVTVYLLISIIL 373
>UniRef50_A7HM59 Cluster: Major facilitator superfamily MFS_1; n=3;
Thermotogaceae|Rep: Major facilitator superfamily MFS_1
- Fervidobacterium nodosum Rt17-B1
Length = 436
Score = 37.5 bits (83), Expect = 0.61
Identities = 29/160 (18%), Positives = 70/160 (43%), Gaps = 8/160 (5%)
Query: 239 LKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTG 298
++ ++++ ++G V ++G+I S F G+++ Y + + L V +L +
Sbjct: 35 IEKEFNVTDSHIGLVGGVFSIVGAIISLFWGFLSDKYNR------KKLLVGSILVGEIPC 88
Query: 299 LIVSIN--VYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVV 356
L+ +I+ W + +G S ++ +V RG ++ ++ ++
Sbjct: 89 LLTAISGSFGQLFFWRVLTGIGVGASFPISYSIVGDLFGHKERGKVVSILGLASTVGSIL 148
Query: 357 APMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTKRK 396
+VAG+T LG AP ++ + + ++Y + K
Sbjct: 149 GMLVAGYTANILGWRIPFILVSAPNIILIPLIWYYLDEPK 188
>UniRef50_A6DCZ0 Cluster: Putative MFS metabolite transporter; n=1;
Caminibacter mediatlanticus TB-2|Rep: Putative MFS
metabolite transporter - Caminibacter mediatlanticus
TB-2
Length = 301
Score = 37.5 bits (83), Expect = 0.61
Identities = 20/81 (24%), Positives = 42/81 (51%), Gaps = 2/81 (2%)
Query: 190 NLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKY 249
NL+ K+ + SIN+ K W ++ L+ + G +Y+ + +Y + +S +Y
Sbjct: 111 NLIALFLKEDKKISKKVSSINFKKEWKFWIAVILLQISFGGFYNFFTIY-NLQHGISKEY 169
Query: 250 VGYVISFQGVMGSISSYFIGY 270
+G++ + GV+ I + IG+
Sbjct: 170 IGWLWAI-GVIAEIVIFIIGH 189
>UniRef50_A5N1Q2 Cluster: Predicted permease; n=1; Clostridium
kluyveri DSM 555|Rep: Predicted permease - Clostridium
kluyveri DSM 555
Length = 379
Score = 37.5 bits (83), Expect = 0.61
Identities = 27/114 (23%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 197 NSFKQSFVVL----YSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGY 252
+ FKQS + + ++I W + ++F + G + +Y++ +L T YD+S +
Sbjct: 182 HQFKQSDLPIRKNGWNIPWKRSINLFTAAFITGISSSIYWTFSRSFLTTEYDISTMESMF 241
Query: 253 VISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVY 306
G+ G + +I F + S R + + LL SI L + +I++Y
Sbjct: 242 FWILMGIAGILGGVAGNFIKQF---GLATSYRGVLLVLLTSICLITIPSTISIY 292
>UniRef50_A0LW56 Cluster: Major facilitator superfamily MFS_1; n=1;
Acidothermus cellulolyticus 11B|Rep: Major facilitator
superfamily MFS_1 - Acidothermus cellulolyticus (strain
ATCC 43068 / 11B)
Length = 431
Score = 37.5 bits (83), Expect = 0.61
Identities = 19/69 (27%), Positives = 32/69 (46%)
Query: 8 GLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCS 67
GL++P +P R GAN VG + S +A +L + +G + D+ G R +
Sbjct: 42 GLVVPALPLFARDFGANKAAVGAVISTFAAMRLAAALGVGKVVDILGERVVLALGIAIVA 101
Query: 68 VAYTVLGLT 76
V+ G +
Sbjct: 102 VSSAATGFS 110
>UniRef50_A2T9T6 Cluster: SecY-independent transporter protein; n=1;
Oscarella carmela|Rep: SecY-independent transporter
protein - Oscarella carmela
Length = 253
Score = 37.5 bits (83), Expect = 0.61
Identities = 35/183 (19%), Positives = 71/183 (38%), Gaps = 5/183 (2%)
Query: 137 HIMEDNPNGAFMFIAFIVGICFIFNAALVCFLXXXXXXXXXXXXXXXXDVLSENLVL-SL 195
H+ E G ++ + FI+ I +N D++ L+L S+
Sbjct: 4 HLNELKLRGVYLTLGFIITIIISYNYCEEIIFLVFYLSYINIQEFEINDIIQSKLILTSV 63
Query: 196 FNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYV-I 254
+ ++ + + I ++ ++ A G +Y Y L++ Y+ + I
Sbjct: 64 YEGLFSYLLISCGLAFFVMMPIINFQLILFIASGYHYYEYRKLLRSFLLCIIIYLLTIYI 123
Query: 255 SFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIP 314
+ + I + G+ ++ +V+ +L I LTGLI + V ++WLIP
Sbjct: 124 GYNWINPIILKFVRGFSSTXPPIEVNIKASEXSSYL---IKLTGLITCVGVIITLLWLIP 180
Query: 315 LAM 317
M
Sbjct: 181 SFM 183
>UniRef50_A0D3V9 Cluster: Chromosome undetermined scaffold_37, whole
genome shotgun sequence; n=3; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_37, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 1177
Score = 37.5 bits (83), Expect = 0.61
Identities = 33/133 (24%), Positives = 57/133 (42%), Gaps = 13/133 (9%)
Query: 266 YFIGYINSFYKKDVDYSLRSLHVFLLLSISLT-------GLIVSINVYNYVIWLIPLAMG 318
Y+IG N+ + + + S+ +F L+ + V + YN +W ++M
Sbjct: 960 YYIGQKNTIFTSEKFFKWFSIGIFQGLACFFSFYFELNDTTFVKQSGYNNDLWFFSMSMS 1019
Query: 319 NAVSRLVTLEMVLKRSDGD------HRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSY 372
A+ LVTL++ L + GT +G + +S ++ T Q L SY
Sbjct: 1020 TAIMILVTLKLALNTQFWTIITWVAYLGTSLGTYFAYMWVSNIIPSSAIYGTTQMLFSSY 1079
Query: 373 VIYASLAPTVLGL 385
Y SLA +VL +
Sbjct: 1080 AFYLSLALSVLSM 1092
>UniRef50_Q8ZVA8 Cluster: Drug resistance protein, conjectural;
n=3; Pyrobaculum|Rep: Drug resistance protein,
conjectural - Pyrobaculum aerophilum
Length = 383
Score = 37.5 bits (83), Expect = 0.61
Identities = 21/66 (31%), Positives = 33/66 (50%)
Query: 9 LIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSV 68
L++ L+P ++ K+G + VG SIYA + P+ G L+D GRR +
Sbjct: 27 LVVFLLPFYIFKLGGGGVEVGFAFSIYATAVVAVRPVAGYLTDRLGRRSANLLGGLILAS 86
Query: 69 AYTVLG 74
A +LG
Sbjct: 87 AMILLG 92
>UniRef50_Q0W6V9 Cluster: Putative permease; n=1; uncultured
methanogenic archaeon RC-I|Rep: Putative permease -
Uncultured methanogenic archaeon RC-I
Length = 403
Score = 37.5 bits (83), Expect = 0.61
Identities = 37/182 (20%), Positives = 75/182 (41%), Gaps = 9/182 (4%)
Query: 218 FLYKALVGFAMGVYYSNY----ALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINS 273
F+ +L+ F + V YS ++Y K LS +G +++ G+M YF+ +
Sbjct: 213 FMVFSLLSFLVFVVYSQMYTPLSMYSKGYAGLSEPEIGVLLAINGIMVVTLQYFVTRVAD 272
Query: 274 FYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKR 333
++ + +S+ +F +L + + ++LI + + +TL L
Sbjct: 273 RFR--MTFSMTVGILFYAAGFALVSVSQGFAMLAICLFLITIGELWFIPAQITLATNL-- 328
Query: 334 SDGDHRGTLIGASNSVRSLSGVVAPMVAG-FTGQFLGVSYVIYASLAPTVLGLVMSYHYR 392
S + RG +G S ++ V P++ G F G + ++ +A L + Y
Sbjct: 329 STSETRGRYLGFSGLTTNMGSAVGPLIGGMLLSVFAGSPWAMWLVVATAGLLCAAGFLYL 388
Query: 393 TK 394
K
Sbjct: 389 KK 390
>UniRef50_Q9B6C8 Cluster: NADH-ubiquinone oxidoreductase chain 2;
n=2; Yarrowia lipolytica|Rep: NADH-ubiquinone
oxidoreductase chain 2 - Yarrowia lipolytica (Candida
lipolytica)
Length = 469
Score = 37.5 bits (83), Expect = 0.61
Identities = 28/122 (22%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Query: 185 DVLSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYD 244
++ + NL +LF K+ ++L+ IN I + + + +Y++YL T
Sbjct: 86 NLYNNNLYKTLFEP-KKELIILFLINILGALLIVHSNDFITLFVAIELQSYSIYLITAIY 144
Query: 245 LSPKYVGYVISFQGVMGSISSYFIGY-INSFYKKDVDYSLRSLHVFLLLSISLTGLIVSI 303
S MG I S I Y IN++Y Y+L SL ++ ++ L +++++
Sbjct: 145 NSSYKASKASMLYFFMGGILSILIAYSINTYYSVLNSYTLHSLDSLIINTLDLNLILIAL 204
Query: 304 NV 305
++
Sbjct: 205 SL 206
>UniRef50_UPI000023D093 Cluster: hypothetical protein FG02457.1;
n=2; Gibberella zeae PH-1|Rep: hypothetical protein
FG02457.1 - Gibberella zeae PH-1
Length = 842
Score = 37.1 bits (82), Expect = 0.81
Identities = 37/150 (24%), Positives = 57/150 (38%), Gaps = 3/150 (2%)
Query: 9 LIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSV 68
+ P +P + +G + L + Y FQ + IGSL+D GRR
Sbjct: 385 IYFPALPAIAKDLGVTTSQINLTVTTYMIFQGITPMFIGSLADSGGRRPAYVVCFTIYIA 444
Query: 69 AYTVLGLT-XXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVG 127
A L L T L A+V D + ++ + G A S +G
Sbjct: 445 ANIGLALVPSYGALLGLRCLQSAGSASTVALCFAVVADVVTSAER-GQYIGITAVPSVLG 503
Query: 128 ITLGPMIGGHIMED-NPNGAFMFIAFIVGI 156
+LGP+IGG + + F F+A G+
Sbjct: 504 PSLGPVIGGLLAQYLGWRSIFWFLAIFSGV 533
>UniRef50_Q97TH0 Cluster: Permease, MDR related; n=5;
Clostridiales|Rep: Permease, MDR related - Clostridium
acetobutylicum
Length = 489
Score = 37.1 bits (82), Expect = 0.81
Identities = 33/149 (22%), Positives = 67/149 (44%), Gaps = 5/149 (3%)
Query: 250 VGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYV 309
+ V S + +IS+ G I Y + +L + + LL +L G +S N+Y +
Sbjct: 46 ISLVFSVYLLTSAISTPIYGKIADLYGRK--RALSTGIIIFLLGSALCG--ISSNMYELI 101
Query: 310 IWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLG 369
++ +G V+ +V + RG + G +SV ++ ++ P + GF ++
Sbjct: 102 LFRALQGIGAGSIFTVSYTIVGDVFSLEERGKVQGWISSVWGIASLLGPFIGGFFIDYMS 161
Query: 370 VSYVIYASLAPTVLGLVMSYHYRTKRKVD 398
+++ Y +L + LV+ K KV+
Sbjct: 162 WNWIFYINLPFGIFSLVL-LEKNLKEKVE 189
>UniRef50_Q73LC4 Cluster: Putative uncharacterized protein; n=1;
Treponema denticola|Rep: Putative uncharacterized
protein - Treponema denticola
Length = 926
Score = 37.1 bits (82), Expect = 0.81
Identities = 35/127 (27%), Positives = 58/127 (45%), Gaps = 8/127 (6%)
Query: 253 VISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVF-----LLLSISLTGLIVSINVYN 307
V++ QG+ S G S Y D++ S ++ V+ + I+ G + I+
Sbjct: 776 VLTEQGLFSLKPSLIQGKEESVYSIDLNSSCKTQPVYSEKLKMFFLITDNGFLYKIDTEC 835
Query: 308 YVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQF 367
+I IPL NA L+TL + SDG + G NS+ + S ++P + GF
Sbjct: 836 NIIDKIPLKQKNASDYLITL--IDLDSDGYDDVLVSGGGNSIYAYSANLSP-INGFPVAG 892
Query: 368 LGVSYVI 374
G+ Y+I
Sbjct: 893 TGIPYLI 899
>UniRef50_Q7D0K3 Cluster: AGR_C_1532p; n=4; Rhizobium/Agrobacterium
group|Rep: AGR_C_1532p - Agrobacterium tumefaciens
(strain C58 / ATCC 33970)
Length = 528
Score = 37.1 bits (82), Expect = 0.81
Identities = 33/109 (30%), Positives = 58/109 (53%), Gaps = 9/109 (8%)
Query: 217 IFLYKALVGFAMGVYYSNY-ALYLKTTYDLSPKYVG-YVISFQG--VMGSISSYFIGYIN 272
+ + +L +G+ NY AL+L+TT LSP + G + I+ G VMGS+S+ + I
Sbjct: 295 LLMIVSLTSGGIGIGMVNYYALFLQTTTGLSPSHAGLFFIAVTGGIVMGSLSAGRLISIT 354
Query: 273 SFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAV 321
YK +S+ L + +L+ + T + + ++I ++ LA G AV
Sbjct: 355 GVYK---PFSVAGLTINVLVMLLFTQMHAGTPL--WLIAVLMLAQGFAV 398
>UniRef50_Q0C1P1 Cluster: Major facilitator family transporter; n=1;
Hyphomonas neptunium ATCC 15444|Rep: Major facilitator
family transporter - Hyphomonas neptunium (strain ATCC
15444)
Length = 447
Score = 37.1 bits (82), Expect = 0.81
Identities = 37/148 (25%), Positives = 54/148 (36%), Gaps = 4/148 (2%)
Query: 6 AVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXX 65
+V + P+ +R A L G+I AG +G P IG LSD RR
Sbjct: 229 SVAQLYPVFATSIRPDDAAAFSAQLNGAILAGAMVGLWP-IGLLSDRLDRRIVIAAAAAI 287
Query: 66 CSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAIS- 124
+ A L LT + A+ + EI MA I
Sbjct: 288 GAGAAIGLALTTAINIPFLTLLLAALFGAGSLSYYAVAVANAADRAAPEEITSMMAGILV 347
Query: 125 --GVGITLGPMIGGHIMEDNPNGAFMFI 150
G+G +GP+I G ++ P G +F+
Sbjct: 348 IWGIGSVIGPLIAGAFLQLLPGGGGLFL 375
>UniRef50_A7HJU1 Cluster: Major facilitator superfamily MFS_1; n=1;
Fervidobacterium nodosum Rt17-B1|Rep: Major facilitator
superfamily MFS_1 - Fervidobacterium nodosum Rt17-B1
Length = 389
Score = 37.1 bits (82), Expect = 0.81
Identities = 33/184 (17%), Positives = 79/184 (42%), Gaps = 9/184 (4%)
Query: 217 IFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYK 276
I L+ + G A G+Y + + L L+ + + VG + S + G+ F G + F+
Sbjct: 7 ITLFTFIDGLAQGIYGTLFNLVLRQS-GVPTSIVGKITS-NSLWGAA---FFGLVFGFFA 61
Query: 277 KDVDYSLRSLHVFLLLSISLTGL--IVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRS 334
D + L +F L G+ +++ + + +I + + ++ +++ ++
Sbjct: 62 DKFDK--KKLIIFSQLLGIFFGVYRVITKSYFQLIITSFFFGGFTSATSIILSTLLVLKT 119
Query: 335 DGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTK 394
D D+R G + V +GV+ ++ G G +V+ + + ++ R +
Sbjct: 120 DSDNRAKFFGLNFGVGMFTGVIGNVLGGVLGDMFPAKWVLITASLSRIFAIIPLRKLRIQ 179
Query: 395 RKVD 398
+V+
Sbjct: 180 NEVN 183
>UniRef50_A0LEE5 Cluster: Major facilitator superfamily MFS_1; n=2;
Deltaproteobacteria|Rep: Major facilitator superfamily
MFS_1 - Syntrophobacter fumaroxidans (strain DSM 10017 /
MPOB)
Length = 429
Score = 37.1 bits (82), Expect = 0.81
Identities = 34/134 (25%), Positives = 50/134 (37%), Gaps = 3/134 (2%)
Query: 5 LAVGLIIPLVPGHVRKM-GANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
+ +G + +P + K+ G N GLL + S PL+G LSD GR+
Sbjct: 244 MTMGALEAFLPIYAVKVAGLNEFQAGLLWGAQVLVTIVSKPLMGRLSDRYGRKPAIVIGM 303
Query: 64 XXCSVAYTVLG-LTXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAA 122
C+VA+ + LT + ALV D E+ G
Sbjct: 304 LACAVAFAAIPLLTRFELLILASLLFGLGEAFVTSSSAALVADL-CQERHFGTAMGTFGT 362
Query: 123 ISGVGITLGPMIGG 136
I VG GP++ G
Sbjct: 363 IFDVGHASGPILAG 376
>UniRef50_A3H739 Cluster: Major facilitator superfamily MFS_1; n=2;
Thermoprotei|Rep: Major facilitator superfamily MFS_1 -
Caldivirga maquilingensis IC-167
Length = 389
Score = 37.1 bits (82), Expect = 0.81
Identities = 22/109 (20%), Positives = 49/109 (44%), Gaps = 2/109 (1%)
Query: 283 LRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTL 342
+ S + ++ I+L GLI ++ +Y +I L+ L + + + +++ + + HR
Sbjct: 274 MSSAVLLTVIGIALIGLINNLLIY--IIALLLLGIPHGTTYPLSVVAISRAFKPQHRNMA 331
Query: 343 IGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHY 391
S L G+V P + G+ +G+ + P ++ L+ Y
Sbjct: 332 NSLFFSFMMLIGIVTPTITGYVADLIGIRNTFIVLILPVIIILLFLRRY 380
>UniRef50_UPI0000499E89 Cluster: major facilitator superfamily
protein; n=2; Entamoeba histolytica HM-1:IMSS|Rep: major
facilitator superfamily protein - Entamoeba histolytica
HM-1:IMSS
Length = 528
Score = 36.7 bits (81), Expect = 1.1
Identities = 23/112 (20%), Positives = 46/112 (41%), Gaps = 1/112 (0%)
Query: 27 YVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXX 86
Y G+L + Y Q S +G LSD GRR ++ + G +
Sbjct: 65 YSGILNACYFFSQFLSSFFLGVLSDNIGRRPILLIGSLGSLISTLLFGFSFNYWWAVISR 124
Query: 87 XXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHI 138
+ K + ++ E + A+++G + +G+G+ +G +GG++
Sbjct: 125 SINGLVNGNIGVIKTFMGEFSTKENR-AQVFGLIGLTNGLGMIIGASVGGYL 175
>UniRef50_Q88U53 Cluster: Multidrug transport protein, major
facilitator superfamily; n=1; Lactobacillus
plantarum|Rep: Multidrug transport protein, major
facilitator superfamily - Lactobacillus plantarum
Length = 387
Score = 36.7 bits (81), Expect = 1.1
Identities = 32/146 (21%), Positives = 62/146 (42%), Gaps = 9/146 (6%)
Query: 253 VISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWL 312
V + G++ +S + N +K L L ++S GL+ + +++I +
Sbjct: 244 VWTINGLLIIVSQPIVALFNERFKIGTQIGLG----ITLFALSFLGLVFARQYVDFIIIM 299
Query: 313 IPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAG-FTGQFLGVS 371
+ L +G + + V + D RG G N SL V P+ G QF S
Sbjct: 300 VVLTIGEVIGLPIAPAWVDDMAADDQRGKYQGRYNMALSLGRAVGPLFGGMMVAQF---S 356
Query: 372 Y-VIYASLAPTVLGLVMSYHYRTKRK 396
Y +++ ++ +LG + +R +R+
Sbjct: 357 YSLLFITVTILMLGSLALVLWRARRE 382
>UniRef50_Q81UW3 Cluster: Major facilitator family transporter;
n=12; Bacillus cereus group|Rep: Major facilitator
family transporter - Bacillus anthracis
Length = 393
Score = 36.7 bits (81), Expect = 1.1
Identities = 21/95 (22%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 290 LLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSV 349
++ +I G S N+Y ++ + A+G A +V ++ +G RG + +
Sbjct: 81 IISTIGSIGCAFSANIYLFLFFRAVQAIGIAAIPVVAATIIGDLFEGKERGEAMSLYQML 140
Query: 350 RSLSGVVAPMVAGFTGQFLG-VSYVIYASLAPTVL 383
+L+ + P++ G+ G G VS ++ S+ +L
Sbjct: 141 LALAPAIGPLIGGYLGSINGHVSVFLFLSILGILL 175
>UniRef50_Q47P50 Cluster: Drug resistance transporter Bcr/CflA
subfamily; n=1; Thermobifida fusca YX|Rep: Drug
resistance transporter Bcr/CflA subfamily - Thermobifida
fusca (strain YX)
Length = 435
Score = 36.7 bits (81), Expect = 1.1
Identities = 38/159 (23%), Positives = 65/159 (40%), Gaps = 7/159 (4%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGL-LGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
LA L +P P + V L L S G LG +G +SD GRR
Sbjct: 56 LATDLYLPAFPAIAEDLATTEARVQLTLTSSMLGLALGQ-LAVGPMSDAWGRRTPLLVGT 114
Query: 64 XXCSVAYTV-LGLTXXXXXXXXXXXXXXXXKQTQMLAKALVPD-YENNEQKQAEIYGKMA 121
V + + +T +++ A+V D YE +E A + ++
Sbjct: 115 ALFMVTSLLCMFVTSVEMFIAIRFVQGLAGAAGAVVSHAVVRDLYEGDEA--ARFFSRLM 172
Query: 122 AISGVGITLGPMIGGH-IMEDNPNGAFMFIAFIVGICFI 159
+SG+ LGP++GG ++ + +F +A + G+ F+
Sbjct: 173 LVSGMAPILGPLLGGQLLLVGSWPLSFALLALMNGVGFL 211
>UniRef50_Q30P28 Cluster: Major facilitator superfamily MFS_1; n=2;
Epsilonproteobacteria|Rep: Major facilitator superfamily
MFS_1 - Thiomicrospira denitrificans (strain ATCC 33889
/ DSM 1351)
Length = 406
Score = 36.7 bits (81), Expect = 1.1
Identities = 43/202 (21%), Positives = 91/202 (45%), Gaps = 11/202 (5%)
Query: 194 SLFNSF-KQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGY 252
S F F K S+V+L + K + I + L+ + + L + DL +G+
Sbjct: 209 SSFGKFLKNSYVILKA---DKNFQIQVTTFLLAYGYLIALPFIILDAQQKIDLDGVAIGW 265
Query: 253 VISFQGVMGSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWL 312
+I+ Q V +S++ G ++ K + + L L ++++ + S+ Y + +L
Sbjct: 266 LITTQMVGAMLSNFLWGNLSGRGKNVLTAKVAILAQILAITLAFSAS--SLYEYMLIFFL 323
Query: 313 IPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSY 372
+ +M +R+ + ++LK + D R I ++ SL G+ ++ G F +Y
Sbjct: 324 VGASMDG--NRIASSNLILKIAPADKRPVYIALQMNIVSL-GMFFSILGGVILHFF--NY 378
Query: 373 VIYASLAPTVLGLVMSYHYRTK 394
+ SL+ VL + + + + K
Sbjct: 379 TLLYSLSLGVLFMALLFSLKLK 400
>UniRef50_Q0IBM3 Cluster: Transporter, major facilitator family
protein; n=6; Synechococcus|Rep: Transporter, major
facilitator family protein - Synechococcus sp. (strain
CC9311)
Length = 453
Score = 36.7 bits (81), Expect = 1.1
Identities = 19/75 (25%), Positives = 37/75 (49%)
Query: 312 LIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVS 371
++P+A G A E +++ + HRG + + ++S + AP++AG G
Sbjct: 345 MVPIAFGEAAFLPTAAEAMVEETPLQHRGLAMALFSQCFAISAIAAPLLAGALLDQQGHG 404
Query: 372 YVIYASLAPTVLGLV 386
V++ +A T L +V
Sbjct: 405 LVLWLLMAGTCLAVV 419
>UniRef50_A4SRL1 Cluster: Major facilitator superfamily permease;
n=2; Aeromonas|Rep: Major facilitator superfamily
permease - Aeromonas salmonicida (strain A449)
Length = 412
Score = 36.7 bits (81), Expect = 1.1
Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 6/146 (4%)
Query: 26 IYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXX--- 82
+++G++ +Y FQL P +G LSD GR+ V Y ++ L
Sbjct: 54 VWLGVIMGLYPLFQLVGSPWLGRLSDRHGRKPILTVCLVGVLVGYALMALGIAWRSLPLL 113
Query: 83 XXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDN 142
+ +A+ D + K A + + +G LGPMIGG+
Sbjct: 114 LLSRVVEGFFNGDIAIVQAMAADMSTTKTK-ARSFAWINIGMNLGWVLGPMIGGYAAV-- 170
Query: 143 PNGAFMFIAFIVGICFIFNAALVCFL 168
+G + A++ + N LV +L
Sbjct: 171 VSGDYSLAAWLAVAMTLVNLLLVLWL 196
>UniRef50_A4F7E6 Cluster: Drug resistance transporter, Bcr/CflA
family; n=1; Saccharopolyspora erythraea NRRL 2338|Rep:
Drug resistance transporter, Bcr/CflA family -
Saccharopolyspora erythraea (strain NRRL 23338)
Length = 430
Score = 36.7 bits (81), Expect = 1.1
Identities = 31/137 (22%), Positives = 53/137 (38%), Gaps = 4/137 (2%)
Query: 5 LAVGLIIPLVPGHVRKMGANHIYVGL-LGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
L++ + +P +P R++GA L L ++ G G G +SD GRR
Sbjct: 35 LSIDMYLPALPELTRELGATEAQAQLTLTAVLLGLAFGQ-LFAGPVSDAVGRRKPLLAGL 93
Query: 64 XXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQM-LAKALVPDYENNEQKQAEIYGKMAA 122
A + LT M +A+A V D + + A + +
Sbjct: 94 AVYIAATVLCALTESVHTLAVLRAVQGFGAAAGMVIARASVRDLYSGAEA-ARFFSSLML 152
Query: 123 ISGVGITLGPMIGGHIM 139
+ G+ L P+IGG ++
Sbjct: 153 VVGLAPILAPVIGGQVL 169
>UniRef50_Q9XMS0 Cluster: NADH-ubiquinone oxidoreductase chain 5;
n=5; Tetrahymena|Rep: NADH-ubiquinone oxidoreductase
chain 5 - Tetrahymena pyriformis
Length = 755
Score = 36.7 bits (81), Expect = 1.1
Identities = 50/171 (29%), Positives = 84/171 (49%), Gaps = 24/171 (14%)
Query: 237 LYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFY---KKDVDYSLRSLHVFLLLS 293
L L + ++LS Y YVI +G+I++++ G +++F KK + YS S FL++S
Sbjct: 448 LRLTSLFELS-YYAYYVIP---TIGAITAFYGGLVSAFQSDTKKTLAYSTISHCGFLMVS 503
Query: 294 ISLTGLIVSINVYNYVIWLIP----LAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNS- 348
S TG++ + +Y YV L MGN V+R KR G ++ S
Sbjct: 504 YS-TGVLEYVILYLYVHGFFKAATFLCMGN-VNRFNRNIQDFKRMGGFYKYLPFECFASF 561
Query: 349 --VRSLSGVVAPMVAGFTGQ---FLGVS---YVIYASLAPTVLGLVMSYHY 391
+ +LSG+ P+ GF + F+G++ Y+ Y L+ +LG + Y
Sbjct: 562 VCMINLSGL--PLTLGFYIKHLLFIGLNESYYIYYIILSSLILGAIAGVFY 610
>UniRef50_Q6BL04 Cluster: Similar to CA2053|IPF11029 Candida
albicans IPF11029; n=2; Debaryomyces hansenii|Rep:
Similar to CA2053|IPF11029 Candida albicans IPF11029 -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 500
Score = 36.7 bits (81), Expect = 1.1
Identities = 20/71 (28%), Positives = 36/71 (50%)
Query: 290 LLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSV 349
+LL + L G S VY +++ I + + N +S ++ ++ GT+ G S S
Sbjct: 163 VLLVMGLFGAAYSTTVYQFILSFIAVGISNGLSITPSIGVINHWFSNKKIGTIQGLSTSA 222
Query: 350 RSLSGVVAPMV 360
SL G+V P++
Sbjct: 223 GSLGGLVFPLL 233
>UniRef50_Q4WJ43 Cluster: Tetracycline transporter, putative; n=16;
Pezizomycotina|Rep: Tetracycline transporter, putative -
Aspergillus fumigatus (Sartorya fumigata)
Length = 460
Score = 36.7 bits (81), Expect = 1.1
Identities = 25/107 (23%), Positives = 41/107 (38%), Gaps = 1/107 (0%)
Query: 29 GLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXX 88
G LGS+++ Q + P IG LSD GRR +++ +
Sbjct: 80 GALGSLFSLLQAIAAPFIGRLSDRYGRRTALLCSMVGNTLSVALWVAATDFRTFLASRIV 139
Query: 89 XXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIG 135
+ LA A+ D ++E K+ + A + T GP +G
Sbjct: 140 GGLSEGNVQLAHAIATDI-SDESKRGSTMALVGACFSIAFTCGPALG 185
>UniRef50_Q97C78 Cluster: Putative uncharacterized protein
TVG0232273; n=2; Thermoplasma|Rep: Putative
uncharacterized protein TVG0232273 - Thermoplasma
volcanium
Length = 397
Score = 36.7 bits (81), Expect = 1.1
Identities = 43/166 (25%), Positives = 79/166 (47%), Gaps = 15/166 (9%)
Query: 212 SKYWDIFLYKA---LVGFAMGVYYSNYALYLKTTYDLSP--KYVGYVISFQGVMGSISSY 266
S + D+ LY L F+ G++ + ++ + ++L +Y + Q +M S Y
Sbjct: 16 SNFSDLSLYYISYNLFAFSNGLFGTFINIFFFSKFNLISVVEYQAAIQGTQTLMFVFSGY 75
Query: 267 FIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVT 326
I +N+ Y + RSL +F L I G + + ++ +I+ IP G S T
Sbjct: 76 LIRILNAKYVYSIGNYARSLIIFAL--ILAKGPLFNPIIFG-LIYGIP--SGIFWSGNNT 130
Query: 327 LEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSY 372
L + RS D G + ++++ +G+VAP++AGF + +SY
Sbjct: 131 LSQAVTRSK-DRFG-FLSTNSTIAGAAGLVAPLLAGF---IISISY 171
>UniRef50_P25351 Cluster: Uncharacterized membrane protein YCR023C;
n=2; Saccharomyces cerevisiae|Rep: Uncharacterized
membrane protein YCR023C - Saccharomyces cerevisiae
(Baker's yeast)
Length = 611
Score = 36.7 bits (81), Expect = 1.1
Identities = 25/113 (22%), Positives = 43/113 (38%)
Query: 27 YVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXX 86
Y G L S +A Q+ S G S+ GR+ SV+ +LG +
Sbjct: 60 YSGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVAR 119
Query: 87 XXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIM 139
+ + ++ + + QA + M + G +GPMIGG ++
Sbjct: 120 SLMGLLNGNVGVIRTIIGEIATERKHQALAFSTMPLLFQFGAVVGPMIGGFLV 172
>UniRef50_UPI00015BAF50 Cluster: major facilitator superfamily
MFS_1; n=1; Ignicoccus hospitalis KIN4/I|Rep: major
facilitator superfamily MFS_1 - Ignicoccus hospitalis
KIN4/I
Length = 414
Score = 36.3 bits (80), Expect = 1.4
Identities = 38/166 (22%), Positives = 74/166 (44%), Gaps = 18/166 (10%)
Query: 217 IFLYKALV-GFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMG-SISSYFIGYINSF 274
+F + A GF+ G++ S +Y+ P + +++ G++G +++S + ++ F
Sbjct: 218 VFFFNAFANGFSAGIFMSVLIIYIMQYVTSVPIKLSSLVALSGLLGMALASPLMKRLDEF 277
Query: 275 ---YKKDVDYSLRSLHVFLLLSISLTG----LIVSINVYNYVIWLIPLAMGNAVSRLVTL 327
K V L LH L ++ LT L+ + V N+ I ++ + + VS LV
Sbjct: 278 DFTNKLKVAIGLGLLHKLALAAVGLTKSYFILLAILTVQNFAITVVIPLIRSLVSDLVPR 337
Query: 328 EMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYV 373
E+ K + G + +L +V P+V ++L S V
Sbjct: 338 ELTAK---------VFGMQQAYFNLGMIVGPLVGAALYKWLEASGV 374
>UniRef50_UPI0000D56B97 Cluster: PREDICTED: similar to CG9864-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG9864-PA - Tribolium castaneum
Length = 484
Score = 36.3 bits (80), Expect = 1.4
Identities = 46/176 (26%), Positives = 83/176 (47%), Gaps = 15/176 (8%)
Query: 225 GFAMGVYYSNYA--LYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYS 282
G G+Y+ A +L T + + G + + + I + G I F ++ S
Sbjct: 263 GNLWGLYFLMTAGPKFLSTVLGFNLGHTGILAALPYLARLIFGFIFGLIGDFIRQRKLLS 322
Query: 283 LRSLHV-FLLLS-ISLTGLIVSINVYNY-VIW---LIPLAMG-NAVSRLVTLEMVLKRSD 335
+ F+L S I GL++ +N+ + W L+ L++G N S L L+ +
Sbjct: 323 TIIVRKGFILFSHIIPGGLLLVLNLTGCDITWSIVLLTLSLGSNGASTLTNLQNSQDLAP 382
Query: 336 GDHRGTLIGASNSVRSLSGVVAPMVAG-FTGQFLGVS--YVIY--ASLAPTVLGLV 386
++ GTL G +N V S +G ++P++ G T + G+S ++I+ +L V GLV
Sbjct: 383 -NYAGTLYGIANCVGSTTGFISPIIVGQLTAKNNGMSEWHIIFCIGALVYIVCGLV 437
>UniRef50_Q5HD42 Cluster: Transporter, putative; n=16;
Staphylococcus|Rep: Transporter, putative -
Staphylococcus aureus (strain COL)
Length = 425
Score = 36.3 bits (80), Expect = 1.4
Identities = 27/132 (20%), Positives = 61/132 (46%), Gaps = 4/132 (3%)
Query: 261 GSISSYFIGYINSFYKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNA 320
G+IS +G S K V + ++ F++ ++S+ + + N+Y + WL L +G
Sbjct: 283 GAISDRVLGLGRS---KFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWL-SLGLGGI 338
Query: 321 VSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAP 380
+ + GT+ G N ++ +++P++AG + LG + + P
Sbjct: 339 GISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVP 398
Query: 381 TVLGLVMSYHYR 392
V+ ++M ++ +
Sbjct: 399 AVIAVIMWFYVK 410
>UniRef50_Q4KGW4 Cluster: Drug transporter, putative; n=1;
Pseudomonas fluorescens Pf-5|Rep: Drug transporter,
putative - Pseudomonas fluorescens (strain Pf-5 / ATCC
BAA-477)
Length = 508
Score = 36.3 bits (80), Expect = 1.4
Identities = 21/94 (22%), Positives = 35/94 (37%)
Query: 45 LIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQMLAKALVP 104
L+G L+DL GR+ +A GL A +
Sbjct: 66 LVGRLADLHGRKRVLFIGLTVFGLASLAAGLAGQIDTLIGARVAQGLACAVLYTASGAIV 125
Query: 105 DYENNEQKQAEIYGKMAAISGVGITLGPMIGGHI 138
+Q +G + ++GVG+ +GP++GG I
Sbjct: 126 SSTFETAEQGRAFGVLFGVNGVGLAVGPVLGGLI 159
>UniRef50_Q38ZV9 Cluster: Major facilitator superfamily (MFS_1)
transporter; n=19; Proteobacteria|Rep: Major facilitator
superfamily (MFS_1) transporter - Burkholderia sp.
(strain 383) (Burkholderia cepacia (strain ATCC 17760/
NCIB 9086 / R18194))
Length = 434
Score = 36.3 bits (80), Expect = 1.4
Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 3/65 (4%)
Query: 325 VTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLG 384
+ E V R+ G ++GA + G VAP VAGF G+ + ++ S A +L
Sbjct: 342 IPAETVPPRAIASALGLIMGAGELI---GGFVAPTVAGFAADKYGLQFAMWTSAAGAILA 398
Query: 385 LVMSY 389
V+S+
Sbjct: 399 CVLSF 403
>UniRef50_P70952 Cluster: Putaive orf protein; n=1; Bacillus
subtilis|Rep: Putaive orf protein - Bacillus subtilis
Length = 164
Score = 36.3 bits (80), Expect = 1.4
Identities = 33/153 (21%), Positives = 66/153 (43%), Gaps = 7/153 (4%)
Query: 226 FAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKDVDYSLRS 285
FA + + Y L++K ++ G+ G+ G++ +G ++ + L S
Sbjct: 3 FASSLIFPFYILFVKNIGSSYTQF-GFSYGLFGLSGALIYPLLGRLSERFDSRYFLLLNS 61
Query: 286 LHV-FLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIG 344
+ LLL + G +V + Y++ ++ L + A+ + ++ +D RG IG
Sbjct: 62 WGMAVLLLYVPHIGSVVQV----YIVQVL-LGLFGAMQKHGEKVLIANFTDSGERGKKIG 116
Query: 345 ASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYAS 377
+ ++ A M+ GF F V + YAS
Sbjct: 117 NYHFWTAVFSAAAIMLGGFLADFFTVQMIFYAS 149
>UniRef50_O32182 Cluster: YusP protein; n=13; Bacillus|Rep: YusP
protein - Bacillus subtilis
Length = 541
Score = 36.3 bits (80), Expect = 1.4
Identities = 32/115 (27%), Positives = 48/115 (41%), Gaps = 4/115 (3%)
Query: 44 PLIGSLSDLKGRRXXXXXXXXXCSVAYTVLGLTXXXXXXXXXXXXXXXXKQTQM-LAKAL 102
P+ G L+DL GRR A + G+ M +A +
Sbjct: 66 PIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMTELIIFRGLQGIGGGIMMPMAMIV 125
Query: 103 VPDYENNEQKQAEIYGKMAAISGVGITLGPMIGGHIMEDNPNGAFMF-IAFIVGI 156
+ D +Q+ A+ G AI G+ +GP IGG I+ D+ N ++F I VGI
Sbjct: 126 IGDLFTGKQR-AKFQGVFGAIYGLASVIGPQIGGWIV-DSLNWKWVFYINLPVGI 178
>UniRef50_Q9X7L7 Cluster: ABC transporter; n=6;
Alphaproteobacteria|Rep: ABC transporter - Rhizobium
meliloti (Sinorhizobium meliloti)
Length = 589
Score = 36.3 bits (80), Expect = 1.4
Identities = 27/101 (26%), Positives = 51/101 (50%), Gaps = 9/101 (8%)
Query: 284 RSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLI 343
+S+ ++L+I G ++ + V +++ L AMG+AV R + L ++ L
Sbjct: 74 QSMDTLVMLTILAVGALIVLGVLDFIRALTFQAMGSAVVRWLNLPVLTAAVQASADQGLA 133
Query: 344 GASNSVRSL---------SGVVAPMVAGFTGQFLGVSYVIY 375
A+ S+R L S V AP+ A ++ FLGV ++++
Sbjct: 134 RATQSLRDLTELRSFLTSSAVSAPLDAAWSPIFLGVLFLLH 174
>UniRef50_A6T4B1 Cluster: Transporter of the MFS superfamily; n=1;
Janthinobacterium sp. Marseille|Rep: Transporter of the
MFS superfamily - Janthinobacterium sp. (strain
Marseille) (Minibacterium massiliensis)
Length = 402
Score = 36.3 bits (80), Expect = 1.4
Identities = 33/118 (27%), Positives = 53/118 (44%), Gaps = 10/118 (8%)
Query: 211 WSKY-WDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIG 269
WS+ + L G A+ Y Y YL+ +PK G+ +SF G +G++ S G
Sbjct: 211 WSRVPLTLALATVFAGLAIYGYLGLYPTYLREALGFTPKQAGFAVSFYG-LGALLSLLGG 269
Query: 270 YINSFYKKDVDYSLRSLHVF-LLLSISLTGLIVSINVYNYVIWLI-PLAMGNAVSRLV 325
++ Y+ R L F L+LS GL+ S + + +I G A+S +V
Sbjct: 270 WLGD------RYNYRKLLFFSLVLSAIAGGLLFSGLDKSLTLHVIFSFVFGGAISGMV 321
>UniRef50_A5N066 Cluster: Putative uncharacterized protein; n=1;
Clostridium kluyveri DSM 555|Rep: Putative
uncharacterized protein - Clostridium kluyveri DSM 555
Length = 547
Score = 36.3 bits (80), Expect = 1.4
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Query: 281 YSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRG 340
Y + ++ L+L+IS LI++ + +I++ PL + V+ + V SD
Sbjct: 97 YIILAVSAALVLTISNNFLILATFLVCMIIFVFPLFLLGTVTPSLVKYTVSSLSDNGKIV 156
Query: 341 TLIGASNSVRSLSGVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVMSYHYRTKR 395
++GA N++ S+ G P V+++I++ + +LG++ + K+
Sbjct: 157 GMLGAINTIGSIIGTFLPTFVTIPAVGTSVTFLIFSGIL-LMLGIIYFISIKAKK 210
>UniRef50_A1VG65 Cluster: Major facilitator superfamily MFS_1
precursor; n=2; Desulfovibrio vulgaris subsp.
vulgaris|Rep: Major facilitator superfamily MFS_1
precursor - Desulfovibrio vulgaris subsp. vulgaris
(strain DP4)
Length = 467
Score = 36.3 bits (80), Expect = 1.4
Identities = 35/136 (25%), Positives = 59/136 (43%), Gaps = 5/136 (3%)
Query: 4 LLAVGLIIPLVPGHVRKMGANHIYVGLLGSIYAGFQLGSGPLIGSLSDLKGRRXXXXXXX 63
L AVG+ +P++ GH +GA+ + +GL+ ++Y ++G L D++GRR
Sbjct: 33 LSAVGVALPVI-GH--DLGASAVELGLIETVYVMSLSIFLLMMGRLGDIQGRRRIFRWGV 89
Query: 64 XXCSVAYTVLGL-TXXXXXXXXXXXXXXXXKQTQMLAKALVPDYENNEQKQAEIYGKMAA 122
++A T L + T A+V E + + G AA
Sbjct: 90 GVFTIATTALWVATSVPLFLVLRVVQGMGASMINASGLAMVVSVYPRESRGRAL-GIGAA 148
Query: 123 ISGVGITLGPMIGGHI 138
GI+ GP++GG I
Sbjct: 149 AVYAGISCGPVLGGII 164
>UniRef50_Q4N3Z0 Cluster: Cation-transporting ATPase; n=1; Theileria
parva|Rep: Cation-transporting ATPase - Theileria parva
Length = 2664
Score = 36.3 bits (80), Expect = 1.4
Identities = 51/208 (24%), Positives = 97/208 (46%), Gaps = 28/208 (13%)
Query: 199 FKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVI--SF 256
FKQ +L S + Y+ I YK LV F + ++Y Y + +VG + S
Sbjct: 1132 FKQGTRMLKSTSLIIYFTI--YKGLV-FILPIFY----------YQIFTNWVGLDLYGSL 1178
Query: 257 QGVMGSISSYFIGYINSF-YKKDVDYSLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPL 315
++ + FI I + +D+ Y + + H+ +L +IS + ++IN N + W++
Sbjct: 1179 ITILYHLVFTFIPLIMFILFYQDISYEIYN-HISILYTISRRRIYLNIN--NSLYWMLEG 1235
Query: 316 AMGNAVSRLVTLEMVLKRSDGDHRGTLI-----GASNSVRSLSGVVAPMVAGFT---GQF 367
+G+ V+ L L +++ +D ++ +I G SV S+ ++ +T G F
Sbjct: 1236 ILGSFVNYL-PLHLLVINNDNIYKSEVISNRTFGLLISVSSIIIFNTKLLINYTPNTGNF 1294
Query: 368 LGVSYVIYASLAPTVLGLVMSYHYRTKR 395
+S + Y + P +GLV+ R+ R
Sbjct: 1295 TFISLLYYFASPPLYIGLVLVSSRRSLR 1322
>UniRef50_Q9HRX5 Cluster: Multidrug resistance protein homolog; n=1;
Halobacterium salinarum|Rep: Multidrug resistance
protein homolog - Halobacterium salinarium
(Halobacterium halobium)
Length = 412
Score = 36.3 bits (80), Expect = 1.4
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 3/94 (3%)
Query: 294 ISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLS 353
+ L L+ S V ++ LA G + L TL M + R + GA NS+R
Sbjct: 303 LCLMWLVSSPMVLAGLVVTAGLACGLLNANLSTLAMGISTHS---RPSASGAYNSLRFTG 359
Query: 354 GVVAPMVAGFTGQFLGVSYVIYASLAPTVLGLVM 387
G AP+VAG+ G G + A LGL++
Sbjct: 360 GAFAPIVAGYIGGNYGAALPFLLGAAVITLGLIV 393
>UniRef50_A2BLY7 Cluster: Predicted permease; n=1; Hyperthermus
butylicus DSM 5456|Rep: Predicted permease -
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Length = 391
Score = 36.3 bits (80), Expect = 1.4
Identities = 29/146 (19%), Positives = 68/146 (46%), Gaps = 6/146 (4%)
Query: 219 LYKALVGFAMGVYYSNYALYLKTTYDLSPKYVGYVISFQGVMGSISSYFIGYINSFYKKD 278
LY GF++ Y ++ Y+++ S +G ++ + G++ + G + Y
Sbjct: 15 LYSLFRGFSVSGYQVLFSAYMRSL-GYSMTSIGGAVTVSSLAGALLAPGFGAVIECYGAR 73
Query: 279 VDYSLRSLHVFL-LLSISLTGLIVSINVYNYVIWLIPLAMGNAVSRLVTLEMVLKRSDGD 337
+ +L L + + LL +S+ + V +YV++++ ++G ++ K G+
Sbjct: 74 LTTTLTGLMLVVSLLLLSIPEPGYAAFVASYVLYMLAFSLGQPARST----LLAKSVPGE 129
Query: 338 HRGTLIGASNSVRSLSGVVAPMVAGF 363
G G + +V + + +V P+ AG+
Sbjct: 130 LHGYYTGVTMAVFATARIVGPLTAGW 155
>UniRef50_UPI00006CD0ED Cluster: hypothetical protein
TTHERM_00125290; n=1; Tetrahymena thermophila SB210|Rep:
hypothetical protein TTHERM_00125290 - Tetrahymena
thermophila SB210
Length = 2228
Score = 35.9 bits (79), Expect = 1.9
Identities = 32/150 (21%), Positives = 61/150 (40%), Gaps = 12/150 (8%)
Query: 187 LSENLVLSLFNSFKQSFVVLYSINWSKYWDIFLYKALVGFAMGVYYSNYALYLKTTYDL- 245
+S N++L F + L NW+ Y +F ++A+ + +YY L L+ +
Sbjct: 487 ISNNIILGSFIFIAYGIIFLSIRNWTAYLLLFFFQAVPSLIIFMYYVYDTLKLRNRLHIP 546
Query: 246 SPKYVGYVISFQGVMGSISSYFIGYINSFYKKDV--DYSLRSLHVFLLL-SISLTGLIVS 302
SP Y+ F YF F KD+ +++ + + F+L I L++
Sbjct: 547 SPDYIQCAYIF-------GLYFFWMATFFVIKDLRESFNISARNFFMLFWCIVTAALVIG 599
Query: 303 INVYNY-VIWLIPLAMGNAVSRLVTLEMVL 331
VY W + G+ +++ +L
Sbjct: 600 YTVYTVSTTWNLDFYWGDHYIKILAGPYIL 629
>UniRef50_Q8YJH9 Cluster: GLUCARATE TRANSPORTER; n=6; Brucella|Rep:
GLUCARATE TRANSPORTER - Brucella melitensis
Length = 455
Score = 35.9 bits (79), Expect = 1.9
Identities = 20/90 (22%), Positives = 45/90 (50%), Gaps = 1/90 (1%)
Query: 309 VIWLIPLAMG-NAVSRLVTLEMVLKRSDGDHRGTLIGASNSVRSLSGVVAPMVAGFTGQF 367
VI L+ LA N++ V +++ S D GT G ++ + +++ +++P +AG
Sbjct: 366 VIGLMTLANACNSLPNSVYWAVIIDSSPTDKMGTYSGITHFIANIATILSPTLAGILAMS 425
Query: 368 LGVSYVIYASLAPTVLGLVMSYHYRTKRKV 397
G + + A+ T +G++ + ++V
Sbjct: 426 YGYNAMFVATAVATAIGMIAMLSVKPGQRV 455
>UniRef50_Q8D526 Cluster: ABC-type dipeptide/oligopeptide/nickel
transport system, permease component; n=2; Vibrio
vulnificus|Rep: ABC-type dipeptide/oligopeptide/nickel
transport system, permease component - Vibrio vulnificus
Length = 386
Score = 35.9 bits (79), Expect = 1.9
Identities = 22/79 (27%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
Query: 259 VMGSISSYFIGYINSFYKKDVDY--SLRSLHVFLLLSISLTGLIVSINVYNYVIWLIPLA 316
V+G IS YF G I++F ++ +++ S+ +L +++ LS SL S+ Y + ++ L
Sbjct: 194 VIGGISGYFGGAIDNFIQRSIEFMKSIPTLPLWMALSASLPAEWSSLTKYFLITIILGLV 253
Query: 317 MGNAVSRLVTLEMVLKRSD 335
++R+V + RS+
Sbjct: 254 SWPDMARVVRSRFMSLRSE 272
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.325 0.142 0.419
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 386,728,421
Number of Sequences: 1657284
Number of extensions: 14925767
Number of successful extensions: 53723
Number of sequences better than 10.0: 397
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 257
Number of HSP's that attempted gapping in prelim test: 53133
Number of HSP's gapped (non-prelim): 691
length of query: 398
length of database: 575,637,011
effective HSP length: 102
effective length of query: 296
effective length of database: 406,594,043
effective search space: 120351836728
effective search space used: 120351836728
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 40 (21.6 bits)
S2: 73 (33.5 bits)
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