Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002426-TA|BGIBMGA002426-PA|IPR001382|Glycoside
hydrolase, family 47
(539 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X74837-1|CAA52831.1| 625|Homo sapiens Man9-mannosidase protein. 519 e-147
AL078600-1|CAB75695.2| 653|Homo sapiens mannosidase, alpha, cla... 519 e-147
AL022722-2|CAI20315.1| 653|Homo sapiens mannosidase, alpha, cla... 519 e-147
BC063300-1|AAH63300.1| 641|Homo sapiens mannosidase, alpha, cla... 517 e-146
AL358072-1|CAH71079.1| 641|Homo sapiens mannosidase, alpha, cla... 517 e-146
AL157902-1|CAI22315.1| 641|Homo sapiens mannosidase, alpha, cla... 517 e-146
AF027156-1|AAC26169.1| 641|Homo sapiens alpha 1,2-mannosidase I... 517 e-146
AL031280-2|CAI19714.1| 630|Homo sapiens mannosidase, alpha, cla... 470 e-132
AF261655-1|AAF97058.1| 630|Homo sapiens 1,2-alpha-mannosidase I... 470 e-132
AL031280-1|CAI19713.1| 450|Homo sapiens mannosidase, alpha, cla... 462 e-129
AB209275-1|BAD92512.1| 482|Homo sapiens mannosidase, alpha, cla... 447 e-125
AL358072-2|CAH71080.1| 343|Homo sapiens mannosidase, alpha, cla... 380 e-105
AL157902-4|CAI22318.1| 343|Homo sapiens mannosidase, alpha, cla... 380 e-105
AK023308-1|BAB14518.1| 618|Homo sapiens protein ( Homo sapiens ... 329 2e-89
BC006079-1|AAH06079.1| 699|Homo sapiens mannosidase, alpha, cla... 302 2e-81
BC002953-1|AAH02953.1| 699|Homo sapiens mannosidase, alpha, cla... 302 2e-81
AY358465-1|AAQ88830.1| 699|Homo sapiens MAN1B1 protein. 302 2e-81
AL929554-19|CAH72887.1| 699|Homo sapiens mannosidase, alpha, cl... 302 2e-81
AL807752-35|CAI12781.1| 699|Homo sapiens mannosidase, alpha, cl... 302 2e-81
AF148509-1|AAF03215.1| 699|Homo sapiens alpha 1,2-mannosidase p... 302 2e-81
AF145732-1|AAD45504.1| 663|Homo sapiens endoplasmic reticulum a... 302 2e-81
AF053626-1|AAC26201.1| 251|Homo sapiens alpha 1,2-mannosidase I... 262 2e-69
AF053621-1|AAC26200.1| 358|Homo sapiens alpha 1,2-mannosidase I... 215 3e-55
AL157902-2|CAI22316.1| 203|Homo sapiens mannosidase, alpha, cla... 208 4e-53
BC065827-1|AAH65827.1| 367|Homo sapiens MAN1A1 protein protein. 177 1e-43
D86967-1|BAA13203.2| 666|Homo sapiens KIAA0212 protein. 141 5e-33
BC019088-1|AAH19088.1| 657|Homo sapiens ER degradation enhancer... 141 5e-33
AL929554-1|CAH72871.2| 329|Homo sapiens mannosidase, alpha, cla... 136 2e-31
AL096819-3|CAI21741.1| 932|Homo sapiens ER degradation enhancer... 120 2e-26
CR457266-1|CAG33547.1| 578|Homo sapiens C20orf31 protein. 118 4e-26
BC016184-1|AAH16184.1| 578|Homo sapiens ER degradation enhancer... 118 4e-26
BC001371-1|AAH01371.1| 578|Homo sapiens ER degradation enhancer... 118 4e-26
AL356652-1|CAH73763.1| 578|Homo sapiens ER degradation enhancer... 118 4e-26
AL135844-1|CAI19292.1| 578|Homo sapiens ER degradation enhancer... 118 4e-26
AK023931-1|BAB14731.1| 578|Homo sapiens protein ( Homo sapiens ... 118 4e-26
AK001645-1|BAA91806.1| 578|Homo sapiens protein ( Homo sapiens ... 118 4e-26
AF288393-1|AAG60613.1| 889|Homo sapiens C1orf22 protein. 117 9e-26
AK074559-1|BAC11060.1| 178|Homo sapiens .2.1.113). protein. 113 1e-24
AY358580-1|AAQ88943.1| 541|Homo sapiens C20orf31 protein. 108 6e-23
AB209276-1|BAD92513.1| 185|Homo sapiens alpha 1,2-mannosidase v... 102 3e-21
BC105586-1|AAI05587.1| 242|Homo sapiens EDEM3 protein protein. 99 2e-20
AL157902-3|CAI22317.1| 97|Homo sapiens mannosidase, alpha, cla... 75 5e-13
AK127005-1|BAC86786.1| 223|Homo sapiens protein ( Homo sapiens ... 54 2e-06
AL096819-2|CAI21740.1| 155|Homo sapiens ER degradation enhancer... 39 0.039
AK023095-1|BAB14402.1| 155|Homo sapiens protein ( Homo sapiens ... 39 0.051
AK074085-1|BAB84911.1| 1887|Homo sapiens FLJ00156 protein protein. 33 1.9
>X74837-1|CAA52831.1| 625|Homo sapiens Man9-mannosidase protein.
Length = 625
Score = 519 bits (1281), Expect = e-147
Identities = 246/454 (54%), Positives = 316/454 (69%), Gaps = 4/454 (0%)
Query: 70 EKQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMG 129
EK+ I EMM+HAWNNYK YAWG NEL PISK H SS+FG+ + GATIVD LDTL++M
Sbjct: 166 EKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIK-GATIVDALDTLFIME 224
Query: 130 LTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADA 189
+ EF E + W+ E+ + N +++E+SVFE IRFVGGLLS Y L+G+ IFR KA E+
Sbjct: 225 MKHEFEEAKSWVEENLDFN-VNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVK 283
Query: 190 LLPAFETPTGLPYALINPSTKASRQYHWADS-NSILSELGTLHLEFSYLSDVTGREVYKN 248
LLPAF TP+G+P+AL+N + R + WA +SIL+E GTLHLEF +LS ++G ++
Sbjct: 284 LLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAE 343
Query: 249 KVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDE 308
KV IR VL +EKP LYPNY+NP +GQWGQ H+S+G LGDSFYEYLLKAWL S++ D
Sbjct: 344 KVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDL 403
Query: 309 QARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLE 368
+A+ M+ A+QA ++R S SGL Y+AE K G ++E KM HL+CFAGGMFAL A
Sbjct: 404 EAKKMYFDAVQAIETHLIRKSSSGLTYIAEWKRG-LLEHKMGHLTCFAGGMFALGADAAP 462
Query: 369 NSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFE 428
++ Y+++ ++ TCHESY R+ KLGPEAFRF VEA A + +EK Y+LRPE E
Sbjct: 463 EGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEKYYILRPEVME 522
Query: 429 SYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
+Y MWRLT + KYR W WEAV+ALE HCRV GGY+GL +VY + DDVQQS+FLAET
Sbjct: 523 TYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFLAET 582
Query: 489 XXXXXXXXXXXXXXXXXEWVFNTEAHPLPIKGKN 522
W+FN+EAH LPI K+
Sbjct: 583 LKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKD 616
>AL078600-1|CAB75695.2| 653|Homo sapiens mannosidase, alpha, class
1A, member 1 protein.
Length = 653
Score = 519 bits (1281), Expect = e-147
Identities = 246/454 (54%), Positives = 316/454 (69%), Gaps = 4/454 (0%)
Query: 70 EKQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMG 129
EK+ I EMM+HAWNNYK YAWG NEL PISK H SS+FG+ + GATIVD LDTL++M
Sbjct: 194 EKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIK-GATIVDALDTLFIME 252
Query: 130 LTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADA 189
+ EF E + W+ E+ + N +++E+SVFE IRFVGGLLS Y L+G+ IFR KA E+
Sbjct: 253 MKHEFEEAKSWVEENLDFN-VNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVK 311
Query: 190 LLPAFETPTGLPYALINPSTKASRQYHWADS-NSILSELGTLHLEFSYLSDVTGREVYKN 248
LLPAF TP+G+P+AL+N + R + WA +SIL+E GTLHLEF +LS ++G ++
Sbjct: 312 LLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAE 371
Query: 249 KVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDE 308
KV IR VL +EKP LYPNY+NP +GQWGQ H+S+G LGDSFYEYLLKAWL S++ D
Sbjct: 372 KVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDL 431
Query: 309 QARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLE 368
+A+ M+ A+QA ++R S SGL Y+AE K G ++E KM HL+CFAGGMFAL A
Sbjct: 432 EAKKMYFDAVQAIETHLIRKSSSGLTYIAEWK-GGLLEHKMGHLTCFAGGMFALGADAAP 490
Query: 369 NSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFE 428
++ Y+++ ++ TCHESY R+ KLGPEAFRF VEA A + +EK Y+LRPE E
Sbjct: 491 EGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEKYYILRPEVME 550
Query: 429 SYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
+Y MWRLT + KYR W WEAV+ALE HCRV GGY+GL +VY + DDVQQS+FLAET
Sbjct: 551 TYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFLAET 610
Query: 489 XXXXXXXXXXXXXXXXXEWVFNTEAHPLPIKGKN 522
W+FN+EAH LPI K+
Sbjct: 611 LKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKD 644
>AL022722-2|CAI20315.1| 653|Homo sapiens mannosidase, alpha, class
1A, member 1 protein.
Length = 653
Score = 519 bits (1281), Expect = e-147
Identities = 246/454 (54%), Positives = 316/454 (69%), Gaps = 4/454 (0%)
Query: 70 EKQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMG 129
EK+ I EMM+HAWNNYK YAWG NEL PISK H SS+FG+ + GATIVD LDTL++M
Sbjct: 194 EKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIK-GATIVDALDTLFIME 252
Query: 130 LTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADA 189
+ EF E + W+ E+ + N +++E+SVFE IRFVGGLLS Y L+G+ IFR KA E+
Sbjct: 253 MKHEFEEAKSWVEENLDFN-VNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVK 311
Query: 190 LLPAFETPTGLPYALINPSTKASRQYHWADS-NSILSELGTLHLEFSYLSDVTGREVYKN 248
LLPAF TP+G+P+AL+N + R + WA +SIL+E GTLHLEF +LS ++G ++
Sbjct: 312 LLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAE 371
Query: 249 KVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDE 308
KV IR VL +EKP LYPNY+NP +GQWGQ H+S+G LGDSFYEYLLKAWL S++ D
Sbjct: 372 KVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDL 431
Query: 309 QARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLE 368
+A+ M+ A+QA ++R S SGL Y+AE K G ++E KM HL+CFAGGMFAL A
Sbjct: 432 EAKKMYFDAVQAIETHLIRKSSSGLTYIAEWK-GGLLEHKMGHLTCFAGGMFALGADAAP 490
Query: 369 NSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFE 428
++ Y+++ ++ TCHESY R+ KLGPEAFRF VEA A + +EK Y+LRPE E
Sbjct: 491 EGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEKYYILRPEVME 550
Query: 429 SYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
+Y MWRLT + KYR W WEAV+ALE HCRV GGY+GL +VY + DDVQQS+FLAET
Sbjct: 551 TYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFLAET 610
Query: 489 XXXXXXXXXXXXXXXXXEWVFNTEAHPLPIKGKN 522
W+FN+EAH LPI K+
Sbjct: 611 LKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKD 644
>BC063300-1|AAH63300.1| 641|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 641
Score = 517 bits (1275), Expect = e-146
Identities = 233/450 (51%), Positives = 319/450 (70%), Gaps = 3/450 (0%)
Query: 70 EKQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMG 129
EK+ I EMM+HAW+NY+ Y WG NEL PI+++ H ++FGS +MGATIVD LDTLY+MG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 130 LTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADA 189
L DEF +G+ WI ++ + + ++SE+SVFE IRF+GGLL+ Y L+G+ IF+ KA ++A+
Sbjct: 239 LHDEFLDGQRWIEDNLDFS-VNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEK 297
Query: 190 LLPAFETPTGLPYALINPSTKASRQYHWADS-NSILSELGTLHLEFSYLSDVTGREVYKN 248
LLPAF TPTG+P+A++N + R + WA + +SIL+E GTLH+EF +LS +TG Y
Sbjct: 298 LLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYK 357
Query: 249 KVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDE 308
KV IR++L +++P LYPNY+NPRTG+WGQ H S+G LGDSFYEYLLKAWL S++ D
Sbjct: 358 KVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH 417
Query: 309 QARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLE 368
+AR M+D A++A +++ S GL ++ E K G +E+KM HL+CFAGGMFAL A
Sbjct: 418 EARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGH-LEKKMGHLACFAGGMFALGADGSR 476
Query: 369 NSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFE 428
+ Y+++ ++ TCHESY R+ KLGPE+F+F AVEA A + EK Y+LRPE E
Sbjct: 477 ADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIE 536
Query: 429 SYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
+Y+ +WR T + +YR WGWEA A+EK+CRV GG++G+ +VY P DDVQQS+FLAET
Sbjct: 537 TYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAET 596
Query: 489 XXXXXXXXXXXXXXXXXEWVFNTEAHPLPI 518
WVFNTEAHPLP+
Sbjct: 597 LKYLYLLFSGDDLLPLDHWVFNTEAHPLPV 626
>AL358072-1|CAH71079.1| 641|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 641
Score = 517 bits (1275), Expect = e-146
Identities = 233/450 (51%), Positives = 319/450 (70%), Gaps = 3/450 (0%)
Query: 70 EKQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMG 129
EK+ I EMM+HAW+NY+ Y WG NEL PI+++ H ++FGS +MGATIVD LDTLY+MG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 130 LTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADA 189
L DEF +G+ WI ++ + + ++SE+SVFE IRF+GGLL+ Y L+G+ IF+ KA ++A+
Sbjct: 239 LHDEFLDGQRWIEDNLDFS-VNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEK 297
Query: 190 LLPAFETPTGLPYALINPSTKASRQYHWADS-NSILSELGTLHLEFSYLSDVTGREVYKN 248
LLPAF TPTG+P+A++N + R + WA + +SIL+E GTLH+EF +LS +TG Y
Sbjct: 298 LLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYK 357
Query: 249 KVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDE 308
KV IR++L +++P LYPNY+NPRTG+WGQ H S+G LGDSFYEYLLKAWL S++ D
Sbjct: 358 KVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH 417
Query: 309 QARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLE 368
+AR M+D A++A +++ S GL ++ E K G +E+KM HL+CFAGGMFAL A
Sbjct: 418 EARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGH-LEKKMGHLACFAGGMFALGADGSR 476
Query: 369 NSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFE 428
+ Y+++ ++ TCHESY R+ KLGPE+F+F AVEA A + EK Y+LRPE E
Sbjct: 477 ADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIE 536
Query: 429 SYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
+Y+ +WR T + +YR WGWEA A+EK+CRV GG++G+ +VY P DDVQQS+FLAET
Sbjct: 537 TYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAET 596
Query: 489 XXXXXXXXXXXXXXXXXEWVFNTEAHPLPI 518
WVFNTEAHPLP+
Sbjct: 597 LKYLYLLFSGDDLLPLDHWVFNTEAHPLPV 626
>AL157902-1|CAI22315.1| 641|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 641
Score = 517 bits (1275), Expect = e-146
Identities = 233/450 (51%), Positives = 319/450 (70%), Gaps = 3/450 (0%)
Query: 70 EKQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMG 129
EK+ I EMM+HAW+NY+ Y WG NEL PI+++ H ++FGS +MGATIVD LDTLY+MG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 130 LTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADA 189
L DEF +G+ WI ++ + + ++SE+SVFE IRF+GGLL+ Y L+G+ IF+ KA ++A+
Sbjct: 239 LHDEFLDGQRWIEDNLDFS-VNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEK 297
Query: 190 LLPAFETPTGLPYALINPSTKASRQYHWADS-NSILSELGTLHLEFSYLSDVTGREVYKN 248
LLPAF TPTG+P+A++N + R + WA + +SIL+E GTLH+EF +LS +TG Y
Sbjct: 298 LLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYK 357
Query: 249 KVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDE 308
KV IR++L +++P LYPNY+NPRTG+WGQ H S+G LGDSFYEYLLKAWL S++ D
Sbjct: 358 KVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH 417
Query: 309 QARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLE 368
+AR M+D A++A +++ S GL ++ E K G +E+KM HL+CFAGGMFAL A
Sbjct: 418 EARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGH-LEKKMGHLACFAGGMFALGADGSR 476
Query: 369 NSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFE 428
+ Y+++ ++ TCHESY R+ KLGPE+F+F AVEA A + EK Y+LRPE E
Sbjct: 477 ADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIE 536
Query: 429 SYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
+Y+ +WR T + +YR WGWEA A+EK+CRV GG++G+ +VY P DDVQQS+FLAET
Sbjct: 537 TYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAET 596
Query: 489 XXXXXXXXXXXXXXXXXEWVFNTEAHPLPI 518
WVFNTEAHPLP+
Sbjct: 597 LKYLYLLFSGDDLLPLDHWVFNTEAHPLPV 626
>AF027156-1|AAC26169.1| 641|Homo sapiens alpha 1,2-mannosidase IB
protein.
Length = 641
Score = 517 bits (1275), Expect = e-146
Identities = 233/450 (51%), Positives = 319/450 (70%), Gaps = 3/450 (0%)
Query: 70 EKQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMG 129
EK+ I EMM+HAW+NY+ Y WG NEL PI+++ H ++FGS +MGATIVD LDTLY+MG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 130 LTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADA 189
L DEF +G+ WI ++ + + ++SE+SVFE IRF+GGLL+ Y L+G+ IF+ KA ++A+
Sbjct: 239 LHDEFLDGQRWIEDNLDFS-VNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEK 297
Query: 190 LLPAFETPTGLPYALINPSTKASRQYHWADS-NSILSELGTLHLEFSYLSDVTGREVYKN 248
LLPAF TPTG+P+A++N + R + WA + +SIL+E GTLH+EF +LS +TG Y
Sbjct: 298 LLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYK 357
Query: 249 KVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDE 308
KV IR++L +++P LYPNY+NPRTG+WGQ H S+G LGDSFYEYLLKAWL S++ D
Sbjct: 358 KVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH 417
Query: 309 QARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLE 368
+AR M+D A++A +++ S GL ++ E K G +E+KM HL+CFAGGMFAL A
Sbjct: 418 EARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGH-LEKKMGHLACFAGGMFALGADGSR 476
Query: 369 NSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFE 428
+ Y+++ ++ TCHESY R+ KLGPE+F+F AVEA A + EK Y+LRPE E
Sbjct: 477 ADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIE 536
Query: 429 SYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
+Y+ +WR T + +YR WGWEA A+EK+CRV GG++G+ +VY P DDVQQS+FLAET
Sbjct: 537 TYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAET 596
Query: 489 XXXXXXXXXXXXXXXXXEWVFNTEAHPLPI 518
WVFNTEAHPLP+
Sbjct: 597 LKYLYLLFSGDDLLPLDHWVFNTEAHPLPV 626
>AL031280-2|CAI19714.1| 630|Homo sapiens mannosidase, alpha, class
1C, member 1 protein.
Length = 630
Score = 470 bits (1158), Expect = e-132
Identities = 225/458 (49%), Positives = 309/458 (67%), Gaps = 9/458 (1%)
Query: 64 DSQSSVEKQRHII-EMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGL 122
+ QS V QR I EMM+ AW +YK YA GKNEL P++K + ++FG G GAT++D L
Sbjct: 166 EPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFG-GLSGATVIDSL 224
Query: 123 DTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDK 182
DTLY+M L +EF+E + W+ E F++N + E S+FE IR++GGLLS + LTG+ +FR K
Sbjct: 225 DTLYLMELKEEFQEAKAWVGESFHLN-VSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIK 283
Query: 183 AAEVADALLPAFETPTGLPYALINPSTKASRQYHWAD--SNSILSELGTLHLEFSYLSDV 240
A + + LLPAF TPTG+P ++ S K S + WA S+SIL+E G+LHLEF +L+++
Sbjct: 284 AIRLGEKLLPAFNTPTGIPKGVV--SFK-SGNWGWATAGSSSILAEFGSLHLEFLHLTEL 340
Query: 241 TGREVYKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAW 300
+G +V+ KV IR+VL IEKP LYPN+++P +G W Q H+S+G LGDSFYEYL+K+W
Sbjct: 341 SGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSW 400
Query: 301 LASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMF 360
L S + D +A+ M+ A++A +L VSP GL Y+AE + G +++ KM HL+CF+GGM
Sbjct: 401 LMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWR-GGILDHKMGHLACFSGGMI 459
Query: 361 ALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVY 420
AL A + Y ++A ++T TCHESY RS+TKLGPEAF F++ EA A + E Y
Sbjct: 460 ALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYY 519
Query: 421 LLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQ 480
+LRPE ESY +WR T YR+WGWE V ALEK+CR E G++G+ +VY P D+ Q
Sbjct: 520 ILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQ 579
Query: 481 QSYFLAETXXXXXXXXXXXXXXXXXEWVFNTEAHPLPI 518
QS+FLAET +WVFNTEAHPLP+
Sbjct: 580 QSFFLAETLKYLYLLFSEDDLLSLEDWVFNTEAHPLPV 617
>AF261655-1|AAF97058.1| 630|Homo sapiens 1,2-alpha-mannosidase IC
protein.
Length = 630
Score = 470 bits (1158), Expect = e-132
Identities = 225/458 (49%), Positives = 309/458 (67%), Gaps = 9/458 (1%)
Query: 64 DSQSSVEKQRHII-EMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGL 122
+ QS V QR I EMM+ AW +YK YA GKNEL P++K + ++FG G GAT++D L
Sbjct: 166 EPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFG-GLSGATVIDSL 224
Query: 123 DTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDK 182
DTLY+M L +EF+E + W+ E F++N + E S+FE IR++GGLLS + LTG+ +FR K
Sbjct: 225 DTLYLMELKEEFQEAKAWVGESFHLN-VSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIK 283
Query: 183 AAEVADALLPAFETPTGLPYALINPSTKASRQYHWAD--SNSILSELGTLHLEFSYLSDV 240
A + + LLPAF TPTG+P ++ S K S + WA S+SIL+E G+LHLEF +L+++
Sbjct: 284 AIRLGEKLLPAFNTPTGIPKGVV--SFK-SGNWGWATAGSSSILAEFGSLHLEFLHLTEL 340
Query: 241 TGREVYKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAW 300
+G +V+ KV IR+VL IEKP LYPN+++P +G W Q H+S+G LGDSFYEYL+K+W
Sbjct: 341 SGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSW 400
Query: 301 LASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMF 360
L S + D +A+ M+ A++A +L VSP GL Y+AE + G +++ KM HL+CF+GGM
Sbjct: 401 LMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWR-GGILDHKMGHLACFSGGMI 459
Query: 361 ALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVY 420
AL A + Y ++A ++T TCHESY RS+TKLGPEAF F++ EA A + E Y
Sbjct: 460 ALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYY 519
Query: 421 LLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQ 480
+LRPE ESY +WR T YR+WGWE V ALEK+CR E G++G+ +VY P D+ Q
Sbjct: 520 ILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQ 579
Query: 481 QSYFLAETXXXXXXXXXXXXXXXXXEWVFNTEAHPLPI 518
QS+FLAET +WVFNTEAHPLP+
Sbjct: 580 QSFFLAETLKYLYLLFSEDDLLSLEDWVFNTEAHPLPV 617
>AL031280-1|CAI19713.1| 450|Homo sapiens mannosidase, alpha, class
1C, member 1 protein.
Length = 450
Score = 462 bits (1140), Expect = e-129
Identities = 218/443 (49%), Positives = 301/443 (67%), Gaps = 8/443 (1%)
Query: 78 MMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREG 137
MM+ AW +YK YA GKNEL P++K + ++FG G GAT++D LDTLY+M L +EF+E
Sbjct: 1 MMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFG-GLSGATVIDSLDTLYLMELKEEFQEA 59
Query: 138 RDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADALLPAFETP 197
+ W+ E F++N + E S+FE IR++GGLLS + LTG+ +FR KA + + LLPAF TP
Sbjct: 60 KAWVGESFHLN-VSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFNTP 118
Query: 198 TGLPYALINPSTKASRQYHWAD--SNSILSELGTLHLEFSYLSDVTGREVYKNKVDKIRE 255
TG+P ++ S K S + WA S+SIL+E G+LHLEF +L++++G +V+ KV IR+
Sbjct: 119 TGIPKGVV--SFK-SGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNIRK 175
Query: 256 VLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDEQARTMFD 315
VL IEKP LYPN+++P +G W Q H+S+G LGDSFYEYL+K+WL S + D +A+ M+
Sbjct: 176 VLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSWLMSGKTDMEAKNMYY 235
Query: 316 TAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLENSFSERY 375
A++A +L VSP GL Y+AE + G +++ KM HL+CF+GGM AL A + Y
Sbjct: 236 EALEAIETYLLNVSPGGLTYIAEWR-GGILDHKMGHLACFSGGMIALGAEDAKEEKRAHY 294
Query: 376 MDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFESYFIMWR 435
++A ++T TCHESY RS+TKLGPEAF F++ EA A + E Y+LRPE ESY +WR
Sbjct: 295 RELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESYMYLWR 354
Query: 436 LTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAETXXXXXXX 495
T YR+WGWE V ALEK+CR E G++G+ +VY P D+ QQS+FLAET
Sbjct: 355 QTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAETLKYLYLL 414
Query: 496 XXXXXXXXXXEWVFNTEAHPLPI 518
+WVFNTEAHPLP+
Sbjct: 415 FSEDDLLSLEDWVFNTEAHPLPV 437
>AB209275-1|BAD92512.1| 482|Homo sapiens mannosidase, alpha, class
1C, member 1 variant protein.
Length = 482
Score = 447 bits (1101), Expect = e-125
Identities = 214/428 (50%), Positives = 296/428 (69%), Gaps = 9/428 (2%)
Query: 64 DSQSSVEKQRHII-EMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGL 122
+ QS V QR I EMM+ AW +YK YA GKNEL P++K + ++FG G GAT++D L
Sbjct: 58 EPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFG-GLSGATVIDSL 116
Query: 123 DTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDK 182
DTLY+M L +EF+E + W+ E F++N + E S+FE IR++GGLLS + LTG+ +FR K
Sbjct: 117 DTLYLMELKEEFQEAKAWVGESFHLN-VSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIK 175
Query: 183 AAEVADALLPAFETPTGLPYALINPSTKASRQYHWAD--SNSILSELGTLHLEFSYLSDV 240
A + + LLPAF TPTG+P ++ S K S + WA S+SIL+E G+LHLEF +L+++
Sbjct: 176 AIRLGEKLLPAFNTPTGIPKGVV--SFK-SGNWGWATAGSSSILAEFGSLHLEFLHLTEL 232
Query: 241 TGREVYKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAW 300
+G +V+ KV IR+VL IEKP LYPN+++P +G W Q H+S+G LGDSFYEYL+K+W
Sbjct: 233 SGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSW 292
Query: 301 LASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMF 360
L S + D +A+ M+ A++A +L VSP GL Y+AE + G +++ KM HL+CF+GGM
Sbjct: 293 LMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWR-GGILDHKMGHLACFSGGMI 351
Query: 361 ALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVY 420
AL A + Y ++A ++T TCHESY RS+TKLGPEAF F++ EA A + E Y
Sbjct: 352 ALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYY 411
Query: 421 LLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQ 480
+LRPE ESY +WR T YR+WGWE V ALEK+CR E G++G+ +VY P D+ Q
Sbjct: 412 ILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQ 471
Query: 481 QSYFLAET 488
QS+FLAET
Sbjct: 472 QSFFLAET 479
>AL358072-2|CAH71080.1| 343|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 343
Score = 380 bits (936), Expect = e-105
Identities = 172/329 (52%), Positives = 237/329 (72%), Gaps = 2/329 (0%)
Query: 161 IRFVGGLLSCYALTGDTIFRDKAAEVADALLPAFETPTGLPYALINPSTKASRQYHWADS 220
IRF+GGLL+ Y L+G+ IF+ KA ++A+ LLPAF TPTG+P+A++N + R + WA +
Sbjct: 1 IRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASA 60
Query: 221 -NSILSELGTLHLEFSYLSDVTGREVYKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWG 279
+SIL+E GTLH+EF +LS +TG Y KV IR++L +++P LYPNY+NPRTG+WG
Sbjct: 61 GSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWG 120
Query: 280 QRHISLGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAEL 339
Q H S+G LGDSFYEYLLKAWL S++ D +AR M+D A++A +++ S GL ++ E
Sbjct: 121 QYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEW 180
Query: 340 KYGWVIEEKMEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGP 399
K G +E+KM HL+CFAGGMFAL A + Y+++ ++ TCHESY R+ KLGP
Sbjct: 181 KNGH-LEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGP 239
Query: 400 EAFRFSNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV 459
E+F+F AVEA A + EK Y+LRPE E+Y+ +WR T + +YR WGWEA A+EK+CRV
Sbjct: 240 ESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRV 299
Query: 460 EGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
GG++G+ +VY P DDVQQS+FLAET
Sbjct: 300 NGGFSGVKDVYSSTPTHDDVQQSFFLAET 328
>AL157902-4|CAI22318.1| 343|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 343
Score = 380 bits (936), Expect = e-105
Identities = 172/329 (52%), Positives = 237/329 (72%), Gaps = 2/329 (0%)
Query: 161 IRFVGGLLSCYALTGDTIFRDKAAEVADALLPAFETPTGLPYALINPSTKASRQYHWADS 220
IRF+GGLL+ Y L+G+ IF+ KA ++A+ LLPAF TPTG+P+A++N + R + WA +
Sbjct: 1 IRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASA 60
Query: 221 -NSILSELGTLHLEFSYLSDVTGREVYKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWG 279
+SIL+E GTLH+EF +LS +TG Y KV IR++L +++P LYPNY+NPRTG+WG
Sbjct: 61 GSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWG 120
Query: 280 QRHISLGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAEL 339
Q H S+G LGDSFYEYLLKAWL S++ D +AR M+D A++A +++ S GL ++ E
Sbjct: 121 QYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEW 180
Query: 340 KYGWVIEEKMEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGP 399
K G +E+KM HL+CFAGGMFAL A + Y+++ ++ TCHESY R+ KLGP
Sbjct: 181 KNGH-LEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGP 239
Query: 400 EAFRFSNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV 459
E+F+F AVEA A + EK Y+LRPE E+Y+ +WR T + +YR WGWEA A+EK+CRV
Sbjct: 240 ESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRV 299
Query: 460 EGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
GG++G+ +VY P DDVQQS+FLAET
Sbjct: 300 NGGFSGVKDVYSSTPTHDDVQQSFFLAET 328
>AK023308-1|BAB14518.1| 618|Homo sapiens protein ( Homo sapiens
cDNA FLJ13246 fis, clone OVARC1000682, highly similar to
PROCESSING ALPHA-1,2-MANNOSIDASE (EC 3.2.1.-). ).
Length = 618
Score = 329 bits (808), Expect = 2e-89
Identities = 153/295 (51%), Positives = 214/295 (72%), Gaps = 3/295 (1%)
Query: 110 GSGEMGATIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLS 169
GS +MGATIVD LDTLY+MGL DEF +G+ WI ++ + + ++SE+SVFE IRF+GGLL+
Sbjct: 9 GSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFS-VNSEVSVFEVNIRFIGGLLA 67
Query: 170 CYALTGDTIFRDKAAEVADALLPAFETPTGLPYALINPSTKASRQYHWADS-NSILSELG 228
Y L+G+ IF+ KA ++A+ LLPAF TPTG+P+A++N + R + WA + +SIL+E G
Sbjct: 68 AYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFG 127
Query: 229 TLHLEFSYLSDVTGREVYKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGAL 288
TLH+EF +LS +TG Y KV IR++L +++P LYPNY+NPRTG+WGQ H S+G L
Sbjct: 128 TLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGL 187
Query: 289 GDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEK 348
GDSFYEYLLKAWL S++ D +AR M+D A++A +++ S GL ++ E K G +E+K
Sbjct: 188 GDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGH-LEKK 246
Query: 349 MEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFR 403
M HL+CFAGGMFAL A + Y+++ ++ TCHESY R+ KLGPE+ R
Sbjct: 247 MGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPESLR 301
>BC006079-1|AAH06079.1| 699|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 699
Score = 302 bits (742), Expect = 2e-81
Identities = 166/458 (36%), Positives = 268/458 (58%), Gaps = 21/458 (4%)
Query: 71 KQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGL 130
+Q+ +I++ HAW Y+ +AWG +EL P+S+ S FG +G T++D LDT++++GL
Sbjct: 249 RQKGVIDVFLHAWKGYRKFAWGHDELKPVSRS--FSEWFG---LGLTLIDALDTMWILGL 303
Query: 131 TDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADAL 190
EF E R W+++ + E D ++++FE+TIR +GGLLS Y L+GD++F KA + + L
Sbjct: 304 RKEFEEARKWVSKKLHF-EKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRL 362
Query: 191 LPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKV 250
+PAF TP+ +PY+ +N T + W S+S ++E+ ++ LEF LS +TG + ++ V
Sbjct: 363 MPAFRTPSKIPYSDVNIGTGVAHPPRWT-SDSTVAEVTSIQLEFRELSRLTGDKKFQEAV 421
Query: 251 DKIREVLYTIE-KPGDLYPNYINPRTGQWGQRHI-SLGALGDSFYEYLLKAWLASNRGDE 308
+K+ + ++ + K L P +IN +G + + +LGA DS+YEYLLK W+ + +
Sbjct: 422 EKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET 481
Query: 309 QARTMFDTAMQAALDKMLRVS-PSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTL 367
Q + A++ +LR S PS L ++ EL +G KM+HL CF G AL +
Sbjct: 482 QLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG-RFSAKMDHLVCFLPGTLALG---V 537
Query: 368 ENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQ----KSDEKVYLLR 423
+ +M++A++L TC++ + ET L PE F+ + + K ++ LLR
Sbjct: 538 YHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLR 597
Query: 424 PETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV-EGGYTGLTNVYH-QNPQGDDVQQ 481
PET ES F ++R+T ++KY+DWGWE +Q+ + RV GGY+ + NV Q P+ D +
Sbjct: 598 PETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKME 657
Query: 482 SYFLAETXXXXXXXXXXXXXXXXXE-WVFNTEAHPLPI 518
S+FL ET + +VFNTEAHPLPI
Sbjct: 658 SFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>BC002953-1|AAH02953.1| 699|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 699
Score = 302 bits (742), Expect = 2e-81
Identities = 166/458 (36%), Positives = 268/458 (58%), Gaps = 21/458 (4%)
Query: 71 KQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGL 130
+Q+ +I++ HAW Y+ +AWG +EL P+S+ S FG +G T++D LDT++++GL
Sbjct: 249 RQKGVIDVFLHAWKGYRKFAWGHDELKPVSRS--FSEWFG---LGLTLIDALDTMWILGL 303
Query: 131 TDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADAL 190
EF E R W+++ + E D ++++FE+TIR +GGLLS Y L+GD++F KA + + L
Sbjct: 304 RKEFEEARKWVSKKLHF-EKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRL 362
Query: 191 LPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKV 250
+PAF TP+ +PY+ +N T + W S+S ++E+ ++ LEF LS +TG + ++ V
Sbjct: 363 MPAFRTPSKIPYSDVNIGTGVAHPPRWT-SDSTVAEVTSIQLEFRELSRLTGDKKFQEAV 421
Query: 251 DKIREVLYTIE-KPGDLYPNYINPRTGQWGQRHI-SLGALGDSFYEYLLKAWLASNRGDE 308
+K+ + ++ + K L P +IN +G + + +LGA DS+YEYLLK W+ + +
Sbjct: 422 EKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET 481
Query: 309 QARTMFDTAMQAALDKMLRVS-PSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTL 367
Q + A++ +LR S PS L ++ EL +G KM+HL CF G AL +
Sbjct: 482 QLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG-RFSAKMDHLVCFLPGTLALG---V 537
Query: 368 ENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQ----KSDEKVYLLR 423
+ +M++A++L TC++ + ET L PE F+ + + K ++ LLR
Sbjct: 538 YHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLR 597
Query: 424 PETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV-EGGYTGLTNVYH-QNPQGDDVQQ 481
PET ES F ++R+T ++KY+DWGWE +Q+ + RV GGY+ + NV Q P+ D +
Sbjct: 598 PETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKME 657
Query: 482 SYFLAETXXXXXXXXXXXXXXXXXE-WVFNTEAHPLPI 518
S+FL ET + +VFNTEAHPLPI
Sbjct: 658 SFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AY358465-1|AAQ88830.1| 699|Homo sapiens MAN1B1 protein.
Length = 699
Score = 302 bits (742), Expect = 2e-81
Identities = 166/458 (36%), Positives = 268/458 (58%), Gaps = 21/458 (4%)
Query: 71 KQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGL 130
+Q+ +I++ HAW Y+ +AWG +EL P+S+ S FG +G T++D LDT++++GL
Sbjct: 249 RQKGVIDVFLHAWKGYRKFAWGHDELKPVSRS--FSEWFG---LGLTLIDALDTMWILGL 303
Query: 131 TDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADAL 190
EF E R W+++ + E D ++++FE+TIR +GGLLS Y L+GD++F KA + + L
Sbjct: 304 RKEFEEARKWVSKKLHF-EKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRL 362
Query: 191 LPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKV 250
+PAF TP+ +PY+ +N T + W S+S ++E+ ++ LEF LS +TG + ++ V
Sbjct: 363 MPAFRTPSKIPYSDVNIGTGVAHPPRWT-SDSTVAEVTSIQLEFRELSRLTGDKKFQEAV 421
Query: 251 DKIREVLYTIE-KPGDLYPNYINPRTGQWGQRHI-SLGALGDSFYEYLLKAWLASNRGDE 308
+K+ + ++ + K L P +IN +G + + +LGA DS+YEYLLK W+ + +
Sbjct: 422 EKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET 481
Query: 309 QARTMFDTAMQAALDKMLRVS-PSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTL 367
Q + A++ +LR S PS L ++ EL +G KM+HL CF G AL +
Sbjct: 482 QLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG-RFSAKMDHLVCFLPGTLALG---V 537
Query: 368 ENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQ----KSDEKVYLLR 423
+ +M++A++L TC++ + ET L PE F+ + + K ++ LLR
Sbjct: 538 YHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLR 597
Query: 424 PETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV-EGGYTGLTNVYH-QNPQGDDVQQ 481
PET ES F ++R+T ++KY+DWGWE +Q+ + RV GGY+ + NV Q P+ D +
Sbjct: 598 PETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKME 657
Query: 482 SYFLAETXXXXXXXXXXXXXXXXXE-WVFNTEAHPLPI 518
S+FL ET + +VFNTEAHPLPI
Sbjct: 658 SFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AL929554-19|CAH72887.1| 699|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 699
Score = 302 bits (742), Expect = 2e-81
Identities = 166/458 (36%), Positives = 268/458 (58%), Gaps = 21/458 (4%)
Query: 71 KQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGL 130
+Q+ +I++ HAW Y+ +AWG +EL P+S+ S FG +G T++D LDT++++GL
Sbjct: 249 RQKGVIDVFLHAWKGYRKFAWGHDELKPVSRS--FSEWFG---LGLTLIDALDTMWILGL 303
Query: 131 TDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADAL 190
EF E R W+++ + E D ++++FE+TIR +GGLLS Y L+GD++F KA + + L
Sbjct: 304 RKEFEEARKWVSKKLHF-EKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRL 362
Query: 191 LPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKV 250
+PAF TP+ +PY+ +N T + W S+S ++E+ ++ LEF LS +TG + ++ V
Sbjct: 363 MPAFRTPSKIPYSDVNIGTGVAHPPRWT-SDSTVAEVTSIQLEFRELSRLTGDKKFQEAV 421
Query: 251 DKIREVLYTIE-KPGDLYPNYINPRTGQWGQRHI-SLGALGDSFYEYLLKAWLASNRGDE 308
+K+ + ++ + K L P +IN +G + + +LGA DS+YEYLLK W+ + +
Sbjct: 422 EKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET 481
Query: 309 QARTMFDTAMQAALDKMLRVS-PSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTL 367
Q + A++ +LR S PS L ++ EL +G KM+HL CF G AL +
Sbjct: 482 QLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG-RFSAKMDHLVCFLPGTLALG---V 537
Query: 368 ENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQ----KSDEKVYLLR 423
+ +M++A++L TC++ + ET L PE F+ + + K ++ LLR
Sbjct: 538 YHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLR 597
Query: 424 PETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV-EGGYTGLTNVYH-QNPQGDDVQQ 481
PET ES F ++R+T ++KY+DWGWE +Q+ + RV GGY+ + NV Q P+ D +
Sbjct: 598 PETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKME 657
Query: 482 SYFLAETXXXXXXXXXXXXXXXXXE-WVFNTEAHPLPI 518
S+FL ET + +VFNTEAHPLPI
Sbjct: 658 SFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AL807752-35|CAI12781.1| 699|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 699
Score = 302 bits (742), Expect = 2e-81
Identities = 166/458 (36%), Positives = 268/458 (58%), Gaps = 21/458 (4%)
Query: 71 KQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGL 130
+Q+ +I++ HAW Y+ +AWG +EL P+S+ S FG +G T++D LDT++++GL
Sbjct: 249 RQKGVIDVFLHAWKGYRKFAWGHDELKPVSRS--FSEWFG---LGLTLIDALDTMWILGL 303
Query: 131 TDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADAL 190
EF E R W+++ + E D ++++FE+TIR +GGLLS Y L+GD++F KA + + L
Sbjct: 304 RKEFEEARKWVSKKLHF-EKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRL 362
Query: 191 LPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKV 250
+PAF TP+ +PY+ +N T + W S+S ++E+ ++ LEF LS +TG + ++ V
Sbjct: 363 MPAFRTPSKIPYSDVNIGTGVAHPPRWT-SDSTVAEVTSIQLEFRELSRLTGDKKFQEAV 421
Query: 251 DKIREVLYTIE-KPGDLYPNYINPRTGQWGQRHI-SLGALGDSFYEYLLKAWLASNRGDE 308
+K+ + ++ + K L P +IN +G + + +LGA DS+YEYLLK W+ + +
Sbjct: 422 EKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET 481
Query: 309 QARTMFDTAMQAALDKMLRVS-PSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTL 367
Q + A++ +LR S PS L ++ EL +G KM+HL CF G AL +
Sbjct: 482 QLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG-RFSAKMDHLVCFLPGTLALG---V 537
Query: 368 ENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQ----KSDEKVYLLR 423
+ +M++A++L TC++ + ET L PE F+ + + K ++ LLR
Sbjct: 538 YHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLR 597
Query: 424 PETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV-EGGYTGLTNVYH-QNPQGDDVQQ 481
PET ES F ++R+T ++KY+DWGWE +Q+ + RV GGY+ + NV Q P+ D +
Sbjct: 598 PETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKME 657
Query: 482 SYFLAETXXXXXXXXXXXXXXXXXE-WVFNTEAHPLPI 518
S+FL ET + +VFNTEAHPLPI
Sbjct: 658 SFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AF148509-1|AAF03215.1| 699|Homo sapiens alpha 1,2-mannosidase
protein.
Length = 699
Score = 302 bits (742), Expect = 2e-81
Identities = 166/458 (36%), Positives = 268/458 (58%), Gaps = 21/458 (4%)
Query: 71 KQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGL 130
+Q+ +I++ HAW Y+ +AWG +EL P+S+ S FG +G T++D LDT++++GL
Sbjct: 249 RQKGVIDVFLHAWKGYRKFAWGHDELKPVSRS--FSEWFG---LGLTLIDALDTMWILGL 303
Query: 131 TDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADAL 190
EF E R W+++ + E D ++++FE+TIR +GGLLS Y L+GD++F KA + + L
Sbjct: 304 RKEFEEARKWVSKKLHF-EKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRL 362
Query: 191 LPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKV 250
+PAF TP+ +PY+ +N T + W S+S ++E+ ++ LEF LS +TG + ++ V
Sbjct: 363 MPAFRTPSKIPYSDVNIGTGVAHPPRWT-SDSTVAEVTSIQLEFRELSRLTGDKKFQEAV 421
Query: 251 DKIREVLYTIE-KPGDLYPNYINPRTGQWGQRHI-SLGALGDSFYEYLLKAWLASNRGDE 308
+K+ + ++ + K L P +IN +G + + +LGA DS+YEYLLK W+ + +
Sbjct: 422 EKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET 481
Query: 309 QARTMFDTAMQAALDKMLRVS-PSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTL 367
Q + A++ +LR S PS L ++ EL +G KM+HL CF G AL +
Sbjct: 482 QLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG-RFSAKMDHLVCFLPGTLALG---V 537
Query: 368 ENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQ----KSDEKVYLLR 423
+ +M++A++L TC++ + ET L PE F+ + + K ++ LLR
Sbjct: 538 YHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLR 597
Query: 424 PETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV-EGGYTGLTNVYH-QNPQGDDVQQ 481
PET ES F ++R+T ++KY+DWGWE +Q+ + RV GGY+ + NV Q P+ D +
Sbjct: 598 PETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKME 657
Query: 482 SYFLAETXXXXXXXXXXXXXXXXXE-WVFNTEAHPLPI 518
S+FL ET + +VFNTEAHPLPI
Sbjct: 658 SFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
>AF145732-1|AAD45504.1| 663|Homo sapiens endoplasmic reticulum
alpha-mannosidase I protein.
Length = 663
Score = 302 bits (742), Expect = 2e-81
Identities = 166/458 (36%), Positives = 268/458 (58%), Gaps = 21/458 (4%)
Query: 71 KQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGL 130
+Q+ +I++ HAW Y+ +AWG +EL P+S+ S FG +G T++D LDT++++GL
Sbjct: 213 RQKGVIDVFLHAWKGYRKFAWGHDELKPVSRS--FSEWFG---LGLTLIDALDTMWILGL 267
Query: 131 TDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADAL 190
EF E R W+++ + E D ++++FE+TIR +GGLLS Y L+GD++F KA + + L
Sbjct: 268 RKEFEEARKWVSKKLHF-EKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRL 326
Query: 191 LPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKV 250
+PAF TP+ +PY+ +N T + W S+S ++E+ ++ LEF LS +TG + ++ V
Sbjct: 327 MPAFRTPSKIPYSDVNIGTGVAHPPRWT-SDSTVAEVTSIQLEFRELSRLTGDKKFQEAV 385
Query: 251 DKIREVLYTIE-KPGDLYPNYINPRTGQWGQRHI-SLGALGDSFYEYLLKAWLASNRGDE 308
+K+ + ++ + K L P +IN +G + + +LGA DS+YEYLLK W+ + +
Sbjct: 386 EKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET 445
Query: 309 QARTMFDTAMQAALDKMLRVS-PSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTL 367
Q + A++ +LR S PS L ++ EL +G KM+HL CF G AL +
Sbjct: 446 QLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG-RFSAKMDHLVCFLPGTLALG---V 501
Query: 368 ENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQ----KSDEKVYLLR 423
+ +M++A++L TC++ + ET L PE F+ + + K ++ LLR
Sbjct: 502 YHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLR 561
Query: 424 PETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV-EGGYTGLTNVYH-QNPQGDDVQQ 481
PET ES F ++R+T ++KY+DWGWE +Q+ + RV GGY+ + NV Q P+ D +
Sbjct: 562 PETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKME 621
Query: 482 SYFLAETXXXXXXXXXXXXXXXXXE-WVFNTEAHPLPI 518
S+FL ET + +VFNTEAHPLPI
Sbjct: 622 SFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 659
>AF053626-1|AAC26201.1| 251|Homo sapiens alpha 1,2-mannosidase IB
protein.
Length = 251
Score = 262 bits (643), Expect = 2e-69
Identities = 119/237 (50%), Positives = 158/237 (66%), Gaps = 1/237 (0%)
Query: 282 HISLGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKY 341
H S+G LGDSFYEYLLKAWL S++ D +AR M+D A++A +++ S GL ++ E K
Sbjct: 1 HTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKN 60
Query: 342 GWVIEEKMEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGPEA 401
G +E+KM HL+CFAGGMFAL A + Y+++ ++ TCHESY R+ KLGPE+
Sbjct: 61 GH-LEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPES 119
Query: 402 FRFSNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEG 461
F+F AVEA A + EK Y+LRPE E+Y+ +WR T + +YR WGWEA A+EK+CRV G
Sbjct: 120 FKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNG 179
Query: 462 GYTGLTNVYHQNPQGDDVQQSYFLAETXXXXXXXXXXXXXXXXXEWVFNTEAHPLPI 518
G++G+ +VY P DDVQQS+FLAET WVFNTEAHPLP+
Sbjct: 180 GFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDDLLPLDHWVFNTEAHPLPV 236
>AF053621-1|AAC26200.1| 358|Homo sapiens alpha 1,2-mannosidase IB
protein.
Length = 358
Score = 215 bits (525), Expect = 3e-55
Identities = 96/181 (53%), Positives = 136/181 (75%), Gaps = 2/181 (1%)
Query: 70 EKQRHIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMG 129
EK+ I EMM+HAW+NY+ Y WG NEL PI+++ H ++FGS +MGATIVD LDTLY+MG
Sbjct: 179 EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG 238
Query: 130 LTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADA 189
L DEF +G+ WI ++ + + ++SE+SVFE IRF+GGLL+ Y L+G+ IF+ KA ++A+
Sbjct: 239 LHDEFLDGQRWIEDNLDFS-VNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEK 297
Query: 190 LLPAFETPTGLPYALINPSTKASRQYHWADS-NSILSELGTLHLEFSYLSDVTGREVYKN 248
LLPAF TPTG+P+A++N + R + WA + +SIL+E GTLH+EF +LS +TG Y
Sbjct: 298 LLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYK 357
Query: 249 K 249
K
Sbjct: 358 K 358
>AL157902-2|CAI22316.1| 203|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 203
Score = 208 bits (508), Expect = 4e-53
Identities = 94/193 (48%), Positives = 125/193 (64%), Gaps = 1/193 (0%)
Query: 326 LRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHT 385
++ S GL ++ E K G +E+KM HL+CFAGGMFAL A + Y+++ ++ T
Sbjct: 1 IKKSRGGLTFIGEWKNGH-LEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIART 59
Query: 386 CHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDW 445
CHESY R+ KLGPE+F+F AVEA A + EK Y+LRPE E+Y+ +WR T + +YR W
Sbjct: 60 CHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQW 119
Query: 446 GWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAETXXXXXXXXXXXXXXXXX 505
GWEA A+EK+CRV GG++G+ +VY P DDVQQS+FLAET
Sbjct: 120 GWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDDLLPLD 179
Query: 506 EWVFNTEAHPLPI 518
WVFNTEAHPLP+
Sbjct: 180 HWVFNTEAHPLPV 192
>BC065827-1|AAH65827.1| 367|Homo sapiens MAN1A1 protein protein.
Length = 367
Score = 177 bits (430), Expect = 1e-43
Identities = 90/175 (51%), Positives = 116/175 (66%), Gaps = 7/175 (4%)
Query: 32 SVHPASRLAREARSLQSNQIEAGNSSSYSGALDSQSSVEKQRHIIEMMRHAWNNYKLYAW 91
S PA RE R+ +IEA + S VE I+MM+HAWNNYK YAW
Sbjct: 184 SREPADAAIREKRAKIKEEIEARKGQANCPGSSSSCEVE-----IQMMKHAWNNYKGYAW 238
Query: 92 GKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEID 151
G NEL PISK H SS+FG+ + GATIVD LDTL++M + EF E + W+ E+ + N ++
Sbjct: 239 GLNELKPISKGGHSSSLFGNIK-GATIVDALDTLFIMEMKHEFEEAKSWVEENLDFN-VN 296
Query: 152 SELSVFETTIRFVGGLLSCYALTGDTIFRDKAAEVADALLPAFETPTGLPYALIN 206
+E+SVFE IRFVGGLLS Y L+G+ IFR KA E+ LLPAF TP+G+P+AL+N
Sbjct: 297 AEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHTPSGIPWALLN 351
>D86967-1|BAA13203.2| 666|Homo sapiens KIAA0212 protein.
Length = 666
Score = 141 bits (342), Expect = 5e-33
Identities = 130/456 (28%), Positives = 218/456 (47%), Gaps = 45/456 (9%)
Query: 59 YSGALDSQSSVEKQRHIIEMMRHAWNNYKLYAWGKNELNPISKR---------AHLSSVF 109
YSGA Q + + M ++NY +A+ ++ELNPI R ++L+
Sbjct: 127 YSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNIND 186
Query: 110 GSGEMGATIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLS 169
G T+VD LDTL +MG + EF++ + + ++ DS + VFE TIR +G LLS
Sbjct: 187 VLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDK-DSTVQVFEATIRVLGSLLS 245
Query: 170 CYALT-------GDTIFRD-------KAAEVADALLPAFE-TPTGLPYALINPSTKASRQ 214
+ + GD +D A ++A LLPAFE T TG+PY +N T
Sbjct: 246 AHRIITDSKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPD 305
Query: 215 YHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKVDKIREVLYTIEKPGD-LYPNYINP 273
++ + + G+L +EF LS + G ++ + + L+ + L N +N
Sbjct: 306 ---TNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNI 362
Query: 274 RTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGL 333
+TG W + LGA DSFYEYLLK+++ G+++ MF+ A Q+ + + R G
Sbjct: 363 QTGHWVGKQSGLGAGLDSFYEYLLKSYILF--GEKEDLEMFNAAYQSIQNYLRR----GR 416
Query: 334 AYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTC-HESYFR 392
E G +++ F+G + +L+ F + + C H Y+
Sbjct: 417 EACNE---GEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYA 473
Query: 393 SETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQA 452
+ G R++ ++A D Y LRPE ES +++++ TK Y G + +Q+
Sbjct: 474 IWKRYGALPERYNWQLQA----PDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQS 529
Query: 453 LEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
LEK+ +V+ GY L +V ++ +D +S+FL+ET
Sbjct: 530 LEKYTKVKCGYATLHHVIDKST--EDRMESFFLSET 563
>BC019088-1|AAH19088.1| 657|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 1 protein.
Length = 657
Score = 141 bits (342), Expect = 5e-33
Identities = 130/456 (28%), Positives = 218/456 (47%), Gaps = 45/456 (9%)
Query: 59 YSGALDSQSSVEKQRHIIEMMRHAWNNYKLYAWGKNELNPISKR---------AHLSSVF 109
YSGA Q + + M ++NY +A+ ++ELNPI R ++L+
Sbjct: 118 YSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNIND 177
Query: 110 GSGEMGATIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLS 169
G T+VD LDTL +MG + EF++ + + ++ DS + VFE TIR +G LLS
Sbjct: 178 VLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDK-DSTVQVFEATIRVLGSLLS 236
Query: 170 CYALT-------GDTIFRD-------KAAEVADALLPAFE-TPTGLPYALINPSTKASRQ 214
+ + GD +D A ++A LLPAFE T TG+PY +N T
Sbjct: 237 AHRIITDSKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPD 296
Query: 215 YHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKVDKIREVLYTIEKPGD-LYPNYINP 273
++ + + G+L +EF LS + G ++ + + L+ + L N +N
Sbjct: 297 ---TNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNI 353
Query: 274 RTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGL 333
+TG W + LGA DSFYEYLLK+++ G+++ MF+ A Q+ + + R G
Sbjct: 354 QTGHWVGKQSGLGAGLDSFYEYLLKSYILF--GEKEDLEMFNAAYQSIQNYLRR----GR 407
Query: 334 AYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTC-HESYFR 392
E G +++ F+G + +L+ F + + C H Y+
Sbjct: 408 EACNE---GEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYA 464
Query: 393 SETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQA 452
+ G R++ ++A D Y LRPE ES +++++ TK Y G + +Q+
Sbjct: 465 IWKRYGALPERYNWQLQA----PDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQS 520
Query: 453 LEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAET 488
LEK+ +V+ GY L +V ++ +D +S+FL+ET
Sbjct: 521 LEKYTKVKCGYATLHHVIDKST--EDRMESFFLSET 554
>AL929554-1|CAH72871.2| 329|Homo sapiens mannosidase, alpha, class
1B, member 1 protein.
Length = 329
Score = 136 bits (328), Expect = 2e-31
Identities = 80/235 (34%), Positives = 131/235 (55%), Gaps = 11/235 (4%)
Query: 232 LEFSYLSDVTGREVYKNKVDKIREVLYTIE-KPGDLYPNYINPRTGQWGQRHI-SLGALG 289
LEF LS +TG + ++ V+K+ + ++ + K L P +IN +G + + +LGA
Sbjct: 1 LEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARA 60
Query: 290 DSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVS-PSGLAYLAELKYGWVIEEK 348
DS+YEYLLK W+ + + Q + A++ +LR S PS L ++ EL +G K
Sbjct: 61 DSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGR-FSAK 119
Query: 349 MEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAV 408
M+HL CF G AL + + +M++A++L TC++ + ET L PE F+
Sbjct: 120 MDHLVCFLPGTLALG---VYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYP 176
Query: 409 EARAQ----KSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV 459
+ + K ++ LLRPET ES F ++R+T ++KY+DWGWE +Q+ + RV
Sbjct: 177 QPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRV 231
>AL096819-3|CAI21741.1| 932|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 3 protein.
Length = 932
Score = 120 bits (288), Expect = 2e-26
Identities = 132/492 (26%), Positives = 215/492 (43%), Gaps = 56/492 (11%)
Query: 56 SSSYSGALDSQSSVEKQR---HIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGS- 111
+S ++ + S EKQ+ ++EM HA+ NY +A+ +EL P++ R + S
Sbjct: 34 TSVWTAGAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSR 93
Query: 112 -------GEMGATIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFV 164
G+ T++D LDTL V+ T EF + + N++ D +SVFET IR +
Sbjct: 94 GDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDN-DVVVSVFETNIRVL 152
Query: 165 GGLLSCYALT------GDTI--FRDKAAEVADAL----LPAFETPTGLPYALINPS--TK 210
GGLL ++L G+ + + D+ ++A L LPAF T +GLPY IN +
Sbjct: 153 GGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIR 212
Query: 211 ASRQYHWADSNSILSELGTLHLEFSYLSDVTGREVYKNKVDKIREVLYTI-EKPGDLYPN 269
++++ + GTL LEF+ LS TG +++ K + L+ ++ +L
Sbjct: 213 KPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGV 272
Query: 270 YINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVS 329
IN TG W ++ +GA DS+YEYLLKA++ GD+ F+T A + + +
Sbjct: 273 TINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVL--LGDDSFLERFNTHYDAIMRYISQ-- 328
Query: 330 PSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAATTLEN-SFSERYMDVARKLTHTCHE 388
P L + K M+ L F G+ L E V +K H
Sbjct: 329 PPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKK--HNFLP 386
Query: 389 SYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWE 448
F ++ FR A + E Y L T + Y++ + G
Sbjct: 387 EAFTTD-------FRVHWAQHPLRPEFAESTYFLYKATGDPYYL-----------EVGKT 428
Query: 449 AVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAE--TXXXXXXXXXXXXXXXXXE 506
++ L K+ RV G+ + +V + +D S+FLAE +
Sbjct: 429 LIENLNKYARVPCGFAAMKDV--RTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIED 486
Query: 507 WVFNTEAHPLPI 518
++F TEAH LP+
Sbjct: 487 YIFTTEAHLLPL 498
>CR457266-1|CAG33547.1| 578|Homo sapiens C20orf31 protein.
Length = 578
Score = 118 bits (285), Expect = 4e-26
Identities = 115/423 (27%), Positives = 198/423 (46%), Gaps = 43/423 (10%)
Query: 78 MMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREG 137
M HA+++Y A+ +EL P++ H +GS + T++D LDTL ++G EF+
Sbjct: 42 MFYHAYDSYLENAFPFDELRPLTCDGH--DTWGSFSL--TLIDALDTLLILGNVSEFQRV 97
Query: 138 RDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAA------------E 185
+ + + + +ID SVFET IR VGGLLS + L+ +A E
Sbjct: 98 VEVLQDSVDF-DIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEE 156
Query: 186 VADALLPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREV 245
A LLPAF+TPTG+PY +N + + + +GT +EF+ LS +TG V
Sbjct: 157 AARKLLPAFQTPTGMPYGTVNLLHGVN---PGETPVTCTAGIGTFIVEFATLSSLTGDPV 213
Query: 246 YKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNR 305
+++ L+ L N+I+ TG+W + +GA DS++EYL+K +
Sbjct: 214 FEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQ- 272
Query: 306 GDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAAT 365
D++ MF A+ R L ++ G V + L + G+ +L
Sbjct: 273 -DKKLMAMF-LEYNKAIRNYTRFDDWYL--WVQMYKGTVSMPVFQSLEAYWPGLQSLIG- 327
Query: 366 TLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPE 425
++N+ T + + ++ L PE + ++ Y LRPE
Sbjct: 328 DIDNAMR----------TFLNYYTVWKQFGGL-PEFYNIPQGYTVEKREG----YPLRPE 372
Query: 426 TFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFL 485
ES ++R T + + G +AV+++EK +VE G+ + ++ ++ + D+ +S+FL
Sbjct: 373 LIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDL--RDHKLDNRMESFFL 430
Query: 486 AET 488
AET
Sbjct: 431 AET 433
>BC016184-1|AAH16184.1| 578|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 2 protein.
Length = 578
Score = 118 bits (285), Expect = 4e-26
Identities = 115/423 (27%), Positives = 198/423 (46%), Gaps = 43/423 (10%)
Query: 78 MMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREG 137
M HA+++Y A+ +EL P++ H +GS + T++D LDTL ++G EF+
Sbjct: 42 MFYHAYDSYLENAFPFDELRPLTCDGH--DTWGSFSL--TLIDALDTLLILGNVSEFQRV 97
Query: 138 RDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAA------------E 185
+ + + + +ID SVFET IR VGGLLS + L+ +A E
Sbjct: 98 VEVLQDSVDF-DIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEE 156
Query: 186 VADALLPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREV 245
A LLPAF+TPTG+PY +N + + + +GT +EF+ LS +TG V
Sbjct: 157 AARKLLPAFQTPTGMPYGTVNLLHGVN---PGETPVTCTAGIGTFIVEFATLSSLTGDPV 213
Query: 246 YKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNR 305
+++ L+ L N+I+ TG+W + +GA DS++EYL+K +
Sbjct: 214 FEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQ- 272
Query: 306 GDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAAT 365
D++ MF A+ R L ++ G V + L + G+ +L
Sbjct: 273 -DKKLMAMF-LEYNKAIRNYTRFDDWYL--WVQMYKGTVSMPVFQSLEAYWPGLQSLIG- 327
Query: 366 TLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPE 425
++N+ T + + ++ L PE + ++ Y LRPE
Sbjct: 328 DIDNAMR----------TFLNYYTVWKQFGGL-PEFYNIPQGYTVEKREG----YPLRPE 372
Query: 426 TFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFL 485
ES ++R T + + G +AV+++EK +VE G+ + ++ ++ + D+ +S+FL
Sbjct: 373 LIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDL--RDHKLDNRMESFFL 430
Query: 486 AET 488
AET
Sbjct: 431 AET 433
>BC001371-1|AAH01371.1| 578|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 2 protein.
Length = 578
Score = 118 bits (285), Expect = 4e-26
Identities = 115/423 (27%), Positives = 198/423 (46%), Gaps = 43/423 (10%)
Query: 78 MMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREG 137
M HA+++Y A+ +EL P++ H +GS + T++D LDTL ++G EF+
Sbjct: 42 MFYHAYDSYLENAFPFDELRPLTCDGH--DTWGSFSL--TLIDALDTLLILGNVSEFQRV 97
Query: 138 RDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAA------------E 185
+ + + + +ID SVFET IR VGGLLS + L+ +A E
Sbjct: 98 VEVLQDSVDF-DIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEE 156
Query: 186 VADALLPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREV 245
A LLPAF+TPTG+PY +N + + + +GT +EF+ LS +TG V
Sbjct: 157 AARKLLPAFQTPTGMPYGTVNLLHGVN---PGETPVTCTAGIGTFIVEFATLSSLTGDPV 213
Query: 246 YKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNR 305
+++ L+ L N+I+ TG+W + +GA DS++EYL+K +
Sbjct: 214 FEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQ- 272
Query: 306 GDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAAT 365
D++ MF A+ R L ++ G V + L + G+ +L
Sbjct: 273 -DKKLMAMF-LEYNKAIRNYTRFDDWYL--WVQMYKGTVSMPVFQSLEAYWPGLQSLIG- 327
Query: 366 TLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPE 425
++N+ T + + ++ L PE + ++ Y LRPE
Sbjct: 328 DIDNAMR----------TFLNYYTVWKQFGGL-PEFYNIPQGYTVEKREG----YPLRPE 372
Query: 426 TFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFL 485
ES ++R T + + G +AV+++EK +VE G+ + ++ ++ + D+ +S+FL
Sbjct: 373 LIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDL--RDHKLDNRMESFFL 430
Query: 486 AET 488
AET
Sbjct: 431 AET 433
>AL356652-1|CAH73763.1| 578|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 2 protein.
Length = 578
Score = 118 bits (285), Expect = 4e-26
Identities = 115/423 (27%), Positives = 198/423 (46%), Gaps = 43/423 (10%)
Query: 78 MMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREG 137
M HA+++Y A+ +EL P++ H +GS + T++D LDTL ++G EF+
Sbjct: 42 MFYHAYDSYLENAFPFDELRPLTCDGH--DTWGSFSL--TLIDALDTLLILGNVSEFQRV 97
Query: 138 RDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAA------------E 185
+ + + + +ID SVFET IR VGGLLS + L+ +A E
Sbjct: 98 VEVLQDSVDF-DIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEE 156
Query: 186 VADALLPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREV 245
A LLPAF+TPTG+PY +N + + + +GT +EF+ LS +TG V
Sbjct: 157 AARKLLPAFQTPTGMPYGTVNLLHGVN---PGETPVTCTAGIGTFIVEFATLSSLTGDPV 213
Query: 246 YKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNR 305
+++ L+ L N+I+ TG+W + +GA DS++EYL+K +
Sbjct: 214 FEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQ- 272
Query: 306 GDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAAT 365
D++ MF A+ R L ++ G V + L + G+ +L
Sbjct: 273 -DKKLMAMF-LEYNKAIRNYTRFDDWYL--WVQMYKGTVSMPVFQSLEAYWPGLQSLIG- 327
Query: 366 TLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPE 425
++N+ T + + ++ L PE + ++ Y LRPE
Sbjct: 328 DIDNAMR----------TFLNYYTVWKQFGGL-PEFYNIPQGYTVEKREG----YPLRPE 372
Query: 426 TFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFL 485
ES ++R T + + G +AV+++EK +VE G+ + ++ ++ + D+ +S+FL
Sbjct: 373 LIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDL--RDHKLDNRMESFFL 430
Query: 486 AET 488
AET
Sbjct: 431 AET 433
>AL135844-1|CAI19292.1| 578|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 2 protein.
Length = 578
Score = 118 bits (285), Expect = 4e-26
Identities = 115/423 (27%), Positives = 198/423 (46%), Gaps = 43/423 (10%)
Query: 78 MMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREG 137
M HA+++Y A+ +EL P++ H +GS + T++D LDTL ++G EF+
Sbjct: 42 MFYHAYDSYLENAFPFDELRPLTCDGH--DTWGSFSL--TLIDALDTLLILGNVSEFQRV 97
Query: 138 RDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAA------------E 185
+ + + + +ID SVFET IR VGGLLS + L+ +A E
Sbjct: 98 VEVLQDSVDF-DIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEE 156
Query: 186 VADALLPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREV 245
A LLPAF+TPTG+PY +N + + + +GT +EF+ LS +TG V
Sbjct: 157 AARKLLPAFQTPTGMPYGTVNLLHGVN---PGETPVTCTAGIGTFIVEFATLSSLTGDPV 213
Query: 246 YKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNR 305
+++ L+ L N+I+ TG+W + +GA DS++EYL+K +
Sbjct: 214 FEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQ- 272
Query: 306 GDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAAT 365
D++ MF A+ R L ++ G V + L + G+ +L
Sbjct: 273 -DKKLMAMF-LEYNKAIRNYTRFDDWYL--WVQMYKGTVSMPVFQSLEAYWPGLQSLIG- 327
Query: 366 TLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPE 425
++N+ T + + ++ L PE + ++ Y LRPE
Sbjct: 328 DIDNAMR----------TFLNYYTVWKQFGGL-PEFYNIPQGYTVEKREG----YPLRPE 372
Query: 426 TFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFL 485
ES ++R T + + G +AV+++EK +VE G+ + ++ ++ + D+ +S+FL
Sbjct: 373 LIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDL--RDHKLDNRMESFFL 430
Query: 486 AET 488
AET
Sbjct: 431 AET 433
>AK023931-1|BAB14731.1| 578|Homo sapiens protein ( Homo sapiens
cDNA FLJ13869 fis, clone THYRO1001287, weakly similar to
MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE (EC
3.2.1.113). ).
Length = 578
Score = 118 bits (285), Expect = 4e-26
Identities = 115/423 (27%), Positives = 198/423 (46%), Gaps = 43/423 (10%)
Query: 78 MMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREG 137
M HA+++Y A+ +EL P++ H +GS + T++D LDTL ++G EF+
Sbjct: 42 MFYHAYDSYLENAFPFDELRPLTCDGH--DTWGSFSL--TLIDALDTLLILGNVSEFQRV 97
Query: 138 RDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAA------------E 185
+ + + + +ID SVFET IR VGGLLS + L+ +A E
Sbjct: 98 VEVLQDSVDF-DIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEE 156
Query: 186 VADALLPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREV 245
A LLPAF+TPTG+PY +N + + + +GT +EF+ LS +TG V
Sbjct: 157 AARKLLPAFQTPTGMPYGTVNLLHGVN---PGETPVTCTAGIGTFIVEFATLSSLTGDPV 213
Query: 246 YKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNR 305
+++ L+ L N+I+ TG+W + +GA DS++EYL+K +
Sbjct: 214 FEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQ- 272
Query: 306 GDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAAT 365
D++ MF A+ R L ++ G V + L + G+ +L
Sbjct: 273 -DKKLMAMF-LEYNKAIRNYTRFDDWYL--WVQMYKGTVSMPVFQSLEAYWPGLQSLIG- 327
Query: 366 TLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPE 425
++N+ T + + ++ L PE + ++ Y LRPE
Sbjct: 328 DIDNAMR----------TFLNYYTVWKQFGGL-PEFYNIPQGYTVEKREG----YPLRPE 372
Query: 426 TFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFL 485
ES ++R T + + G +AV+++EK +VE G+ + ++ ++ + D+ +S+FL
Sbjct: 373 LIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDL--RDHKLDNRMESFFL 430
Query: 486 AET 488
AET
Sbjct: 431 AET 433
>AK001645-1|BAA91806.1| 578|Homo sapiens protein ( Homo sapiens
cDNA FLJ10783 fis, clone NT2RP4000417, weakly similar to
MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE (EC
3.2.1.113). ).
Length = 578
Score = 118 bits (285), Expect = 4e-26
Identities = 115/423 (27%), Positives = 198/423 (46%), Gaps = 43/423 (10%)
Query: 78 MMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGSGEMGATIVDGLDTLYVMGLTDEFREG 137
M HA+++Y A+ +EL P++ H +GS + T++D LDTL ++G EF+
Sbjct: 42 MFYHAYDSYLENAFPFDELRPLTCDGH--DTWGSFSL--TLIDALDTLLILGNVSEFQRV 97
Query: 138 RDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGDTIFRDKAA------------E 185
+ + + + +ID SVFET IR VGGLLS + L+ +A E
Sbjct: 98 VEVLQDSVDF-DIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEE 156
Query: 186 VADALLPAFETPTGLPYALINPSTKASRQYHWADSNSILSELGTLHLEFSYLSDVTGREV 245
A LLPAF+TPTG+PY +N + + + +GT +EF+ LS +TG V
Sbjct: 157 AARKLLPAFQTPTGMPYGTVNLLHGVN---PGETPVTCTAGIGTFIVEFATLSSLTGDPV 213
Query: 246 YKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHISLGALGDSFYEYLLKAWLASNR 305
+++ L+ L N+I+ TG+W + +GA DS++EYL+K +
Sbjct: 214 FEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQ- 272
Query: 306 GDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWVIEEKMEHLSCFAGGMFALAAT 365
D++ MF A+ R L ++ G V + L + G+ +L
Sbjct: 273 -DKKLMAMF-LEYNKAIRNYTRFDDWYL--WVQMYKGTVSMPVFQSLEAYWPGLQSLIG- 327
Query: 366 TLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQKSDEKVYLLRPE 425
++N+ T + + ++ L PE + ++ Y LRPE
Sbjct: 328 DIDNAMR----------TFLNYYTVWKQFGGL-PEFYNIPQGYTVEKREG----YPLRPE 372
Query: 426 TFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFL 485
ES ++R T + + G +AV+++EK +VE G+ + ++ ++ + D+ +S+FL
Sbjct: 373 LIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDL--RDHKLDNRMESFFL 430
Query: 486 AET 488
AET
Sbjct: 431 AET 433
>AF288393-1|AAG60613.1| 889|Homo sapiens C1orf22 protein.
Length = 889
Score = 117 bits (282), Expect = 9e-26
Identities = 131/481 (27%), Positives = 210/481 (43%), Gaps = 56/481 (11%)
Query: 67 SSVEKQR---HIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGS--------GEMG 115
S EKQ+ ++EM HA+ NY +A+ +EL P++ R + S G+
Sbjct: 2 SREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFS 61
Query: 116 ATIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALT- 174
T++D LDTL V+ T EF + + N++ D +SVFET IR +GGLL ++L
Sbjct: 62 LTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDN-DVVVSVFETNIRVLGGLLGGHSLAI 120
Query: 175 -----GDTI--FRDKAAEVADAL----LPAFETPTGLPYALINPS--TKASRQYHWADSN 221
G+ + + D+ ++A L LPAF T +GLPY IN + +++
Sbjct: 121 MLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETD 180
Query: 222 SILSELGTLHLEFSYLSDVTGREVYKNKVDKIREVLYTI-EKPGDLYPNYINPRTGQWGQ 280
+ + GTL LEF+ LS TG +++ K + L+ ++ +L IN TG W +
Sbjct: 181 TCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVR 240
Query: 281 RHISLGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELK 340
+ +GA DS+YEYLLKA++ GD+ F+T A + + + P L + K
Sbjct: 241 KDSGVGAGIDSYYEYLLKAYVL--LGDDSFLERFNTHYDAIMRYISQ--PPLLLDVHIHK 296
Query: 341 YGWVIEEKMEHLSCFAGGMFALAATTLEN-SFSERYMDVARKLTHTCHESYFRSETKLGP 399
M+ L F G+ L E V +K H F ++
Sbjct: 297 PMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKK--HNFLPEAFTTD----- 349
Query: 400 EAFRFSNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV 459
FR A + E Y L T + Y++ + G ++ L K+ RV
Sbjct: 350 --FRVHWAQHPLRPEFAESTYFLYKATGDPYYL-----------EVGKTLIENLNKYARV 396
Query: 460 EGGYTGLTNVYHQNPQGDDVQQSYFLAE--TXXXXXXXXXXXXXXXXXEWVFNTEAHPLP 517
G+ + +V + +D S+FLAE +++F TEAH LP
Sbjct: 397 PCGFAAMKDV--RTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLP 454
Query: 518 I 518
+
Sbjct: 455 L 455
>AK074559-1|BAC11060.1| 178|Homo sapiens .2.1.113). protein.
Length = 178
Score = 113 bits (273), Expect = 1e-24
Identities = 65/177 (36%), Positives = 97/177 (54%), Gaps = 10/177 (5%)
Query: 349 MEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRFSNAV 408
M+HL CF G AL + + +M++A++L TC++ + ET L PE F+
Sbjct: 1 MDHLVCFLPGTLALG---VYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYP 57
Query: 409 EARAQ----KSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRV-EGGY 463
+ + K ++ LLRPET ES F ++R+T ++KY+DWGWE +Q+ + RV GGY
Sbjct: 58 QPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGY 117
Query: 464 TGLTNVYH-QNPQGDDVQQSYFLAETXXXXXXXXXXXXXXXXXE-WVFNTEAHPLPI 518
+ + NV Q P+ D +S+FL ET + +VFNTEAHPLPI
Sbjct: 118 SSINNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 174
>AY358580-1|AAQ88943.1| 541|Homo sapiens C20orf31 protein.
Length = 541
Score = 108 bits (259), Expect = 6e-23
Identities = 104/384 (27%), Positives = 178/384 (46%), Gaps = 39/384 (10%)
Query: 117 TIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCYALTGD 176
T++D LDTL ++G EF+ + + + + +ID SVFET IR VGGLLS + L+
Sbjct: 40 TLIDALDTLLILGNVSEFQRVVEVLQDSVDF-DIDVNASVFETNIRVVGGLLSAHLLSKK 98
Query: 177 TIFRDKAA------------EVADALLPAFETPTGLPYALINPSTKASRQYHWADSNSIL 224
+A E A LLPAF+TPTG+PY +N + +
Sbjct: 99 AGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVN---PGETPVTCT 155
Query: 225 SELGTLHLEFSYLSDVTGREVYKNKVDKIREVLYTIEKPGDLYPNYINPRTGQWGQRHIS 284
+ +GT +EF+ LS +TG V+++ L+ L N+I+ TG+W +
Sbjct: 156 AGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAG 215
Query: 285 LGALGDSFYEYLLKAWLASNRGDEQARTMFDTAMQAALDKMLRVSPSGLAYLAELKYGWV 344
+GA DS++EYL+K + D++ MF A+ R L ++ G V
Sbjct: 216 IGAGVDSYFEYLVKGAILLQ--DKKLMAMF-LEYNKAIRNYTRFDDWYL--WVQMYKGTV 270
Query: 345 IEEKMEHLSCFAGGMFALAATTLENSFSERYMDVARKLTHTCHESYFRSETKLGPEAFRF 404
+ L + G+ +L ++N+ T + + ++ L PE +
Sbjct: 271 SMPVFQSLEAYWPGLQSLIG-DIDNAMR----------TFLNYYTVWKQFGGL-PEFYNI 318
Query: 405 SNAVEARAQKSDEKVYLLRPETFESYFIMWRLTKEQKYRDWGWEAVQALEKHCRVEGGYT 464
++ Y LRPE ES ++R T + + G +AV+++EK +VE G+
Sbjct: 319 PQGYTVEKREG----YPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFA 374
Query: 465 GLTNVYHQNPQGDDVQQSYFLAET 488
+ ++ ++ + D+ +S+FLAET
Sbjct: 375 TIKDL--RDHKLDNRMESFFLAET 396
>AB209276-1|BAD92513.1| 185|Homo sapiens alpha 1,2-mannosidase
variant protein.
Length = 185
Score = 102 bits (245), Expect = 3e-21
Identities = 56/151 (37%), Positives = 85/151 (56%), Gaps = 7/151 (4%)
Query: 375 YMDVARKLTHTCHESYFRSETKLGPEAFRFSNAVEARAQ----KSDEKVYLLRPETFESY 430
+M++A++L TC++ + ET L PE F+ + + K ++ LLRPET ES
Sbjct: 31 HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESL 90
Query: 431 FIMWRLTKEQKYRDWGWEAVQALEKHCRV-EGGYTGLTNVYH-QNPQGDDVQQSYFLAET 488
F ++R+T ++KY+DWGWE +Q+ + RV GGY+ + N Q P+ D +S+FL ET
Sbjct: 91 FYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNAQDPQKPEPRDKMESFFLGET 150
Query: 489 XXXXXXXXXXXXXXXXXE-WVFNTEAHPLPI 518
+ +VFNTEAHPLPI
Sbjct: 151 LKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 181
>BC105586-1|AAI05587.1| 242|Homo sapiens EDEM3 protein protein.
Length = 242
Score = 99 bits (238), Expect = 2e-20
Identities = 73/220 (33%), Positives = 115/220 (52%), Gaps = 18/220 (8%)
Query: 112 GEMGATIVDGLDTLYVMGLTDEFREGRDWIAEHFNINEIDSELSVFETTIRFVGGLLSCY 171
G+ T++D LDTL V+ T EF + + N++ D +SVFET IR +GGLL +
Sbjct: 24 GKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDN-DVVVSVFETNIRVLGGLLGGH 82
Query: 172 ALT------GDTI--FRDKAAEVADAL----LPAFETPTGLPYALINPS--TKASRQYHW 217
+L G+ + + D+ ++A L LPAF T +GLPY IN +
Sbjct: 83 SLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTG 142
Query: 218 ADSNSILSELGTLHLEFSYLSDVTGREVYKNKVDKIREVLYTI-EKPGDLYPNYINPRTG 276
++++ + GTL LEF+ LS TG +++ K + L+ ++ +L IN TG
Sbjct: 143 TETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTG 202
Query: 277 QWGQRHISLGALGDSFYEYLLKAWLASNRGDEQARTMFDT 316
W ++ +GA DS+YEYLLKA++ GD+ F+T
Sbjct: 203 DWVRKDSGVGAGIDSYYEYLLKAYVL--LGDDSFLERFNT 240
>AL157902-3|CAI22317.1| 97|Homo sapiens mannosidase, alpha, class
1A, member 2 protein.
Length = 97
Score = 75.4 bits (177), Expect = 5e-13
Identities = 33/65 (50%), Positives = 40/65 (61%)
Query: 454 EKHCRVEGGYTGLTNVYHQNPQGDDVQQSYFLAETXXXXXXXXXXXXXXXXXEWVFNTEA 513
EK+CRV GG++G+ +VY P DDVQQS+FLAET WVFNTEA
Sbjct: 1 EKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDDLLPLDHWVFNTEA 60
Query: 514 HPLPI 518
HPLP+
Sbjct: 61 HPLPV 65
>AK127005-1|BAC86786.1| 223|Homo sapiens protein ( Homo sapiens
cDNA FLJ45060 fis, clone BRAWH3023415, highly similar
to Homo sapiens alpha 1,2-mannosidase (LOC51697). ).
Length = 223
Score = 53.6 bits (123), Expect = 2e-06
Identities = 31/96 (32%), Positives = 53/96 (55%), Gaps = 3/96 (3%)
Query: 250 VDKIREVLYTIE-KPGDLYPNYINPRTGQWGQRHI-SLGALGDSFYEYLLKAWLASNRGD 307
V+K+ + ++ + K L P +IN +G + + +LGA DS+YEYLLK W+ + +
Sbjct: 94 VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE 153
Query: 308 EQARTMFDTAMQAALDKMLRVS-PSGLAYLAELKYG 342
Q + A++ +LR S PS L ++ EL +G
Sbjct: 154 TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHG 189
>AL096819-2|CAI21740.1| 155|Homo sapiens ER degradation enhancer,
mannosidase alpha-like 3 protein.
Length = 155
Score = 39.1 bits (87), Expect = 0.039
Identities = 25/84 (29%), Positives = 43/84 (51%), Gaps = 11/84 (13%)
Query: 56 SSSYSGALDSQSSVEKQR---HIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGS- 111
+S ++ + S EKQ+ ++EM HA+ NY +A+ +EL P++ R + S
Sbjct: 34 TSVWTAGAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSR 93
Query: 112 -------GEMGATIVDGLDTLYVM 128
G+ T++D LDTL V+
Sbjct: 94 GDVDDALGKFSLTLIDSLDTLVVI 117
>AK023095-1|BAB14402.1| 155|Homo sapiens protein ( Homo sapiens
cDNA FLJ13033 fis, clone NT2RP3001126. ).
Length = 155
Score = 38.7 bits (86), Expect = 0.051
Identities = 25/84 (29%), Positives = 43/84 (51%), Gaps = 11/84 (13%)
Query: 56 SSSYSGALDSQSSVEKQR---HIIEMMRHAWNNYKLYAWGKNELNPISKRAHLSSVFGS- 111
+S ++ + S EKQ+ ++EM HA+ NY +A+ +EL P++ R + S
Sbjct: 34 TSVWTAGAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSR 93
Query: 112 -------GEMGATIVDGLDTLYVM 128
G+ T++D LDTL V+
Sbjct: 94 GDVDDALGKFSLTLIDSLDTLEVI 117
>AK074085-1|BAB84911.1| 1887|Homo sapiens FLJ00156 protein protein.
Length = 1887
Score = 33.5 bits (73), Expect = 1.9
Identities = 15/31 (48%), Positives = 21/31 (67%), Gaps = 2/31 (6%)
Query: 448 EAVQALEKHCRVEGGYT--GLTNVYHQNPQG 476
EA +AL + C+ EGG GL++ Y +NPQG
Sbjct: 1829 EAAEALAQQCQAEGGRGDWGLSSAYRRNPQG 1859
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.318 0.132 0.398
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 76,227,918
Number of Sequences: 224733
Number of extensions: 2982792
Number of successful extensions: 5955
Number of sequences better than 10.0: 46
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 5677
Number of HSP's gapped (non-prelim): 78
length of query: 539
length of database: 73,234,838
effective HSP length: 94
effective length of query: 445
effective length of database: 52,109,936
effective search space: 23188921520
effective search space used: 23188921520
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 68 (31.5 bits)
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