GeneModel BLAST Result against human

BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA002415-TA|BGIBMGA002415-PA|IPR006172|DNA-directed DNA
polymerase B, IPR012337|Polynucleotidyl transferase, Ribonuclease H
fold, IPR004578|DNA polymerase (pol2), IPR006133|DNA polymerase B,
exonuclease, IPR006134|DNA polymerase B region
         (1644 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

AY684169-1|AAT74627.1| 3052|Homo sapiens REV3-like, catalytic su...   725   0.0  
AL512325-2|CAI20998.1| 3130|Homo sapiens REV3-like, catalytic su...   725   0.0  
AL512325-1|CAI20997.1| 3052|Homo sapiens REV3-like, catalytic su...   725   0.0  
AL136310-1|CAI20509.1| 3130|Homo sapiens REV3-like, catalytic su...   725   0.0  
AL080317-3|CAI19192.1| 3130|Homo sapiens REV3-like, catalytic su...   725   0.0  
AL080317-2|CAI19191.1| 3052|Homo sapiens REV3-like, catalytic su...   725   0.0  
AF179429-1|AAG09403.1| 3052|Homo sapiens DNA polymerase zeta cat...   725   0.0  
AF179428-1|AAG09402.1| 3052|Homo sapiens DNA polymerase zeta cat...   725   0.0  
AF157476-1|AAD40184.1| 3130|Homo sapiens DNA polymerase zeta cat...   725   0.0  
AF078695-1|AAC28460.1| 3052|Homo sapiens DNA polymerase zeta cat...   725   0.0  
AF071798-1|AAC24009.1| 3130|Homo sapiens DNA polymerase zeta cat...   725   0.0  
AF058701-1|AAC24357.1| 3130|Homo sapiens DNA polymerase zeta cat...   725   0.0  
AF035537-1|AAB88486.1| 3052|Homo sapiens DNA polymerase zeta pro...   725   0.0  
AB209256-1|BAD92493.1|  750|Homo sapiens REV3-like, catalytic su...   358   1e-97
AF004713-1|AAF21598.1|  356|Homo sapiens DNA-dependent DNA polym...   262   1e-68
BC008800-1|AAH08800.1| 1107|Homo sapiens polymerase (DNA directe...   250   2e-65
AY129569-1|AAM76971.1| 1107|Homo sapiens polymerase (DNA directe...   250   2e-65
M81735-1|AAA35768.1| 1107|Homo sapiens DNA polymerase delta prot...   249   6e-65
M80397-1|AAA58439.1| 1107|Homo sapiens DNA polymerase-delta cata...   248   1e-64
AB209560-1|BAD92797.1| 1011|Homo sapiens polymerase (DNA directe...   235   7e-61
DQ234348-1|ABB29977.1| 1133|Homo sapiens DNA-directed polymerase...   232   7e-60
BC035823-1|AAH35823.1|  608|Homo sapiens Similar to REV3-like, c...   213   4e-54
AY275833-1|AAP13534.1| 1462|Homo sapiens polymerase (DNA directe...   101   2e-20
X06745-1|CAA29920.1| 1462|Homo sapiens protein ( Human mRNA for ...   100   4e-20
AF051164-1|AAC83554.1| 1147|Homo sapiens heart muscle inducible ...    37   0.53 
AF049656-1|AAC83553.1| 1147|Homo sapiens inducible nitric oxide ...    37   0.53 
BC034992-1|AAH34992.1|  201|Homo sapiens sorting nexin 10 protein.     36   0.92 
BC031050-1|AAH31050.1|  201|Homo sapiens sorting nexin 10 protein.     36   1.6  
AF121860-1|AAD27833.1|  201|Homo sapiens sorting nexin 10 protein.     34   4.9  
L14721-1|AAA35522.1|  957|Homo sapiens aminopeptidase A protein.       33   6.5  
L12468-1|AAA16876.1|  957|Homo sapiens aminopeptidase A protein.       33   6.5  
BC094770-1|AAH94770.1|  957|Homo sapiens glutamyl aminopeptidase...    33   6.5  
AF163151-1|AAF42472.1| 1253|Homo sapiens dentin sialophosphoprot...    33   6.5  
AF094508-1|AAD16120.1|  788|Homo sapiens dentin phosphoryn protein.    33   6.5  
AL353596-4|CAI17914.1|  632|Homo sapiens HBS1-like (S. cerevisia...    33   8.6  
AJ459827-1|CAD30874.1|  632|Homo sapiens HBS1-like protein protein.    33   8.6  

>AY684169-1|AAT74627.1| 3052|Homo sapiens REV3-like, catalytic subunit
            of DNA polymerase zeta (yeast) protein.
          Length = 3052

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2141 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2200

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2201 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2260

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2261 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2320

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2321 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2380

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2381 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2440

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2441 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2500

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2501 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2560

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2561 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2618

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2619 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2678

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2679 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2738

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2739 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2798

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2799 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2858

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2859 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2918

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2919 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 2976

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 2977 SKCRSQPQHVAVIL 2990



 Score =  153 bits (370), Expect = 7e-36
 Identities = 90/248 (36%), Positives = 146/248 (58%), Gaps = 38/248 (15%)

Query: 66  IAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGLIKQAVE 125
           +A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P ++K+  E
Sbjct: 1   MAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICE 60

Query: 126 LFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN------ 179
           L  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN      
Sbjct: 61  LLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSNTLHATG 118

Query: 180 ------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQRIGKGDG 218
                       + L+  +++ + S         +S+C  E D +A+ I+NR  I    G
Sbjct: 119 SCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLDIEAQIG 178

Query: 219 IENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK-------FENIFA 270
             NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++        +N F+
Sbjct: 179 -GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFS 237

Query: 271 VKLSNKID 278
           V LS  +D
Sbjct: 238 VTLSGSVD 245



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1799 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1858

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1859 LAEFEGDFSLEGLRLWK 1875


>AL512325-2|CAI20998.1| 3130|Homo sapiens REV3-like, catalytic subunit
            of DNA polymerase zeta (yeast) protein.
          Length = 3130

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2219 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2278

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2279 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2338

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2339 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2398

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2399 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2458

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2459 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2518

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2519 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2578

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2579 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2638

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2639 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2696

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2697 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2756

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2757 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2816

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2817 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2876

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2877 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2936

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2937 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2996

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2997 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 3054

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 3055 SKCRSQPQHVAVIL 3068



 Score =  213 bits (520), Expect = 4e-54
 Identities = 118/314 (37%), Positives = 183/314 (58%), Gaps = 39/314 (12%)

Query: 1   MTKPTAGLDVTYSEFRGTDIKQVPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEP 60
           M  P  GLD   S      +K+VPV+R+FG    G K CLH+HG+FPY Y+P      +P
Sbjct: 13  MASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQP 72

Query: 61  Q-LLYQIAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGL 119
           +  L Q+A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P +
Sbjct: 73  ESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTM 132

Query: 120 IKQAVELFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN 179
           +K+  EL  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN
Sbjct: 133 VKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSN 190

Query: 180 ------------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQR 212
                             + L+  +++ + S         +S+C  E D +A+ I+NR  
Sbjct: 191 TLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLD 250

Query: 213 IGKGDGIENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK------- 264
           I    G  NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++       
Sbjct: 251 IEAQIG-GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEIL 309

Query: 265 FENIFAVKLSNKID 278
            +N F+V LS  +D
Sbjct: 310 KQNDFSVTLSGSVD 323



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1877 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1936

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1937 LAEFEGDFSLEGLRLWK 1953


>AL512325-1|CAI20997.1| 3052|Homo sapiens REV3-like, catalytic subunit
            of DNA polymerase zeta (yeast) protein.
          Length = 3052

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2141 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2200

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2201 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2260

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2261 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2320

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2321 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2380

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2381 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2440

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2441 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2500

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2501 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2560

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2561 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2618

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2619 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2678

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2679 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2738

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2739 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2798

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2799 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2858

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2859 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2918

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2919 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 2976

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 2977 SKCRSQPQHVAVIL 2990



 Score =  153 bits (370), Expect = 7e-36
 Identities = 90/248 (36%), Positives = 146/248 (58%), Gaps = 38/248 (15%)

Query: 66  IAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGLIKQAVE 125
           +A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P ++K+  E
Sbjct: 1   MAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICE 60

Query: 126 LFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN------ 179
           L  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN      
Sbjct: 61  LLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSNTLHATG 118

Query: 180 ------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQRIGKGDG 218
                       + L+  +++ + S         +S+C  E D +A+ I+NR  I    G
Sbjct: 119 SCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLDIEAQIG 178

Query: 219 IENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK-------FENIFA 270
             NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++        +N F+
Sbjct: 179 -GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFS 237

Query: 271 VKLSNKID 278
           V LS  +D
Sbjct: 238 VTLSGSVD 245



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1799 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1858

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1859 LAEFEGDFSLEGLRLWK 1875


>AL136310-1|CAI20509.1| 3130|Homo sapiens REV3-like, catalytic subunit
            of DNA polymerase zeta (yeast) protein.
          Length = 3130

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2219 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2278

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2279 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2338

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2339 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2398

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2399 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2458

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2459 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2518

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2519 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2578

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2579 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2638

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2639 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2696

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2697 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2756

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2757 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2816

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2817 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2876

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2877 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2936

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2937 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2996

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2997 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 3054

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 3055 SKCRSQPQHVAVIL 3068



 Score =  213 bits (520), Expect = 4e-54
 Identities = 118/314 (37%), Positives = 183/314 (58%), Gaps = 39/314 (12%)

Query: 1   MTKPTAGLDVTYSEFRGTDIKQVPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEP 60
           M  P  GLD   S      +K+VPV+R+FG    G K CLH+HG+FPY Y+P      +P
Sbjct: 13  MASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQP 72

Query: 61  Q-LLYQIAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGL 119
           +  L Q+A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P +
Sbjct: 73  ESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTM 132

Query: 120 IKQAVELFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN 179
           +K+  EL  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN
Sbjct: 133 VKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSN 190

Query: 180 ------------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQR 212
                             + L+  +++ + S         +S+C  E D +A+ I+NR  
Sbjct: 191 TLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLD 250

Query: 213 IGKGDGIENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK------- 264
           I    G  NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++       
Sbjct: 251 IEAQIG-GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEIL 309

Query: 265 FENIFAVKLSNKID 278
            +N F+V LS  +D
Sbjct: 310 KQNDFSVTLSGSVD 323



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1877 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1936

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1937 LAEFEGDFSLEGLRLWK 1953


>AL080317-3|CAI19192.1| 3130|Homo sapiens REV3-like, catalytic subunit
            of DNA polymerase zeta (yeast) protein.
          Length = 3130

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2219 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2278

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2279 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2338

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2339 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2398

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2399 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2458

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2459 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2518

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2519 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2578

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2579 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2638

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2639 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2696

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2697 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2756

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2757 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2816

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2817 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2876

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2877 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2936

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2937 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2996

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2997 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 3054

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 3055 SKCRSQPQHVAVIL 3068



 Score =  213 bits (520), Expect = 4e-54
 Identities = 118/314 (37%), Positives = 183/314 (58%), Gaps = 39/314 (12%)

Query: 1   MTKPTAGLDVTYSEFRGTDIKQVPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEP 60
           M  P  GLD   S      +K+VPV+R+FG    G K CLH+HG+FPY Y+P      +P
Sbjct: 13  MASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQP 72

Query: 61  Q-LLYQIAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGL 119
           +  L Q+A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P +
Sbjct: 73  ESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTM 132

Query: 120 IKQAVELFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN 179
           +K+  EL  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN
Sbjct: 133 VKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSN 190

Query: 180 ------------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQR 212
                             + L+  +++ + S         +S+C  E D +A+ I+NR  
Sbjct: 191 TLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLD 250

Query: 213 IGKGDGIENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK------- 264
           I    G  NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++       
Sbjct: 251 IEAQIG-GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEIL 309

Query: 265 FENIFAVKLSNKID 278
            +N F+V LS  +D
Sbjct: 310 KQNDFSVTLSGSVD 323



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1877 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1936

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1937 LAEFEGDFSLEGLRLWK 1953


>AL080317-2|CAI19191.1| 3052|Homo sapiens REV3-like, catalytic subunit
            of DNA polymerase zeta (yeast) protein.
          Length = 3052

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2141 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2200

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2201 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2260

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2261 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2320

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2321 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2380

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2381 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2440

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2441 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2500

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2501 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2560

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2561 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2618

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2619 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2678

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2679 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2738

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2739 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2798

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2799 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2858

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2859 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2918

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2919 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 2976

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 2977 SKCRSQPQHVAVIL 2990



 Score =  153 bits (370), Expect = 7e-36
 Identities = 90/248 (36%), Positives = 146/248 (58%), Gaps = 38/248 (15%)

Query: 66  IAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGLIKQAVE 125
           +A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P ++K+  E
Sbjct: 1   MAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICE 60

Query: 126 LFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN------ 179
           L  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN      
Sbjct: 61  LLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSNTLHATG 118

Query: 180 ------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQRIGKGDG 218
                       + L+  +++ + S         +S+C  E D +A+ I+NR  I    G
Sbjct: 119 SCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLDIEAQIG 178

Query: 219 IENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK-------FENIFA 270
             NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++        +N F+
Sbjct: 179 -GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFS 237

Query: 271 VKLSNKID 278
           V LS  +D
Sbjct: 238 VTLSGSVD 245



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1799 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1858

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1859 LAEFEGDFSLEGLRLWK 1875


>AF179429-1|AAG09403.1| 3052|Homo sapiens DNA polymerase zeta
            catalytic subunit variant 2 protein.
          Length = 3052

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2141 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2200

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2201 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2260

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2261 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2320

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2321 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2380

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2381 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2440

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2441 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2500

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2501 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2560

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2561 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2618

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2619 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2678

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2679 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2738

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2739 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2798

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2799 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2858

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2859 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2918

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2919 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 2976

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 2977 SKCRSQPQHVAVIL 2990



 Score =  153 bits (370), Expect = 7e-36
 Identities = 90/248 (36%), Positives = 146/248 (58%), Gaps = 38/248 (15%)

Query: 66  IAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGLIKQAVE 125
           +A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P ++K+  E
Sbjct: 1   MAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICE 60

Query: 126 LFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN------ 179
           L  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN      
Sbjct: 61  LLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSNTLHATG 118

Query: 180 ------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQRIGKGDG 218
                       + L+  +++ + S         +S+C  E D +A+ I+NR  I    G
Sbjct: 119 SCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLDIEAQIG 178

Query: 219 IENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK-------FENIFA 270
             NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++        +N F+
Sbjct: 179 -GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFS 237

Query: 271 VKLSNKID 278
           V LS  +D
Sbjct: 238 VTLSGSVD 245



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1799 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1858

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1859 LAEFEGDFSLEGLRLWK 1875


>AF179428-1|AAG09402.1| 3052|Homo sapiens DNA polymerase zeta
            catalytic subunit variant 1 protein.
          Length = 3052

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2141 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2200

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2201 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2260

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2261 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2320

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2321 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2380

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2381 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2440

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2441 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2500

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2501 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2560

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2561 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2618

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2619 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2678

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2679 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2738

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2739 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2798

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2799 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2858

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2859 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2918

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2919 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 2976

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 2977 SKCRSQPQHVAVIL 2990



 Score =  153 bits (370), Expect = 7e-36
 Identities = 90/248 (36%), Positives = 146/248 (58%), Gaps = 38/248 (15%)

Query: 66  IAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGLIKQAVE 125
           +A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P ++K+  E
Sbjct: 1   MAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICE 60

Query: 126 LFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN------ 179
           L  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN      
Sbjct: 61  LLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSNTLHATG 118

Query: 180 ------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQRIGKGDG 218
                       + L+  +++ + S         +S+C  E D +A+ I+NR  I    G
Sbjct: 119 SCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLDIEAQIG 178

Query: 219 IENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK-------FENIFA 270
             NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++        +N F+
Sbjct: 179 -GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFS 237

Query: 271 VKLSNKID 278
           V LS  +D
Sbjct: 238 VTLSGSVD 245



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1799 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1858

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1859 LAEFEGDFSLEGLRLWK 1875


>AF157476-1|AAD40184.1| 3130|Homo sapiens DNA polymerase zeta
            catalytic subunit protein.
          Length = 3130

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2219 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2278

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2279 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2338

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2339 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2398

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2399 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2458

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2459 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2518

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2519 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2578

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2579 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2638

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2639 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2696

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2697 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2756

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2757 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2816

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2817 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2876

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2877 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2936

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2937 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2996

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2997 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 3054

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 3055 SKCRSQPQHVAVIL 3068



 Score =  213 bits (520), Expect = 4e-54
 Identities = 118/314 (37%), Positives = 183/314 (58%), Gaps = 39/314 (12%)

Query: 1   MTKPTAGLDVTYSEFRGTDIKQVPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEP 60
           M  P  GLD   S      +K+VPV+R+FG    G K CLH+HG+FPY Y+P      +P
Sbjct: 13  MASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQP 72

Query: 61  Q-LLYQIAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGL 119
           +  L Q+A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P +
Sbjct: 73  ESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTM 132

Query: 120 IKQAVELFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN 179
           +K+  EL  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN
Sbjct: 133 VKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSN 190

Query: 180 ------------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQR 212
                             + L+  +++ + S         +S+C  E D +A+ I+NR  
Sbjct: 191 TLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLD 250

Query: 213 IGKGDGIENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK------- 264
           I    G  NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++       
Sbjct: 251 IEAQIG-GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEIL 309

Query: 265 FENIFAVKLSNKID 278
            +N F+V LS  +D
Sbjct: 310 KQNDFSVTLSGSVD 323



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1877 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1936

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1937 LAEFEGDFSLEGLRLWK 1953


>AF078695-1|AAC28460.1| 3052|Homo sapiens DNA polymerase zeta
            catalytic subunit protein.
          Length = 3052

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2141 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2200

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2201 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2260

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2261 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2320

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2321 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2380

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2381 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2440

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2441 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2500

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2501 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2560

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2561 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2618

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2619 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2678

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2679 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2738

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2739 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2798

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2799 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2858

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2859 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2918

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2919 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 2976

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 2977 SKCRSQPQHVAVIL 2990



 Score =  151 bits (365), Expect = 3e-35
 Identities = 89/248 (35%), Positives = 145/248 (58%), Gaps = 38/248 (15%)

Query: 66  IAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGLIKQAVE 125
           +A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P ++K+  E
Sbjct: 1   MAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICE 60

Query: 126 LFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN------ 179
           L  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN      
Sbjct: 61  LLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSNTLHATG 118

Query: 180 ------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQRIGKGDG 218
                       + L+  +++ + S          S+C  + D +A+ I+NR  I    G
Sbjct: 119 SCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPHSTCELQVDAVAADILNRLDIEAQIG 178

Query: 219 IENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK-------FENIFA 270
             NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++        +N F+
Sbjct: 179 -GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFS 237

Query: 271 VKLSNKID 278
           V LS  +D
Sbjct: 238 VTLSGSVD 245



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1799 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1858

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1859 LAEFEGDFSLEGLRLWK 1875


>AF071798-1|AAC24009.1| 3130|Homo sapiens DNA polymerase zeta
            catalytic subunit protein.
          Length = 3130

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2219 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2278

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2279 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2338

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2339 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2398

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2399 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2458

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2459 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2518

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2519 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2578

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2579 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2638

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2639 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2696

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2697 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2756

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2757 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2816

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2817 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2876

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2877 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2936

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2937 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2996

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2997 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 3054

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 3055 SKCRSQPQHVAVIL 3068



 Score =  213 bits (520), Expect = 4e-54
 Identities = 118/314 (37%), Positives = 183/314 (58%), Gaps = 39/314 (12%)

Query: 1   MTKPTAGLDVTYSEFRGTDIKQVPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEP 60
           M  P  GLD   S      +K+VPV+R+FG    G K CLH+HG+FPY Y+P      +P
Sbjct: 13  MASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQP 72

Query: 61  Q-LLYQIAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGL 119
           +  L Q+A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P +
Sbjct: 73  ESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTM 132

Query: 120 IKQAVELFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN 179
           +K+  EL  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN
Sbjct: 133 VKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSN 190

Query: 180 ------------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQR 212
                             + L+  +++ + S         +S+C  E D +A+ I+NR  
Sbjct: 191 TLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLD 250

Query: 213 IGKGDGIENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK------- 264
           I    G  NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++       
Sbjct: 251 IEAQIG-GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEIL 309

Query: 265 FENIFAVKLSNKID 278
            +N F+V LS  +D
Sbjct: 310 KQNDFSVTLSGSVD 323



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1877 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1936

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1937 LAEFEGDFSLEGLRLWK 1953


>AF058701-1|AAC24357.1| 3130|Homo sapiens DNA polymerase zeta
            catalytic subunit protein.
          Length = 3130

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2219 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2278

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2279 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2338

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2339 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2398

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2399 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2458

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2459 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2518

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2519 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2578

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2579 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2638

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2639 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2696

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2697 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2756

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2757 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2816

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2817 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2876

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2877 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2936

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2937 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2996

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2997 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 3054

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 3055 SKCRSQPQHVAVIL 3068



 Score =  213 bits (520), Expect = 4e-54
 Identities = 118/314 (37%), Positives = 183/314 (58%), Gaps = 39/314 (12%)

Query: 1   MTKPTAGLDVTYSEFRGTDIKQVPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEP 60
           M  P  GLD   S      +K+VPV+R+FG    G K CLH+HG+FPY Y+P      +P
Sbjct: 13  MASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQP 72

Query: 61  Q-LLYQIAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGL 119
           +  L Q+A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P +
Sbjct: 73  ESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTM 132

Query: 120 IKQAVELFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN 179
           +K+  EL  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN
Sbjct: 133 VKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSN 190

Query: 180 ------------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQR 212
                             + L+  +++ + S         +S+C  E D +A+ I+NR  
Sbjct: 191 TLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLD 250

Query: 213 IGKGDGIENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK------- 264
           I    G  NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++       
Sbjct: 251 IEAQIG-GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEIL 309

Query: 265 FENIFAVKLSNKID 278
            +N F+V LS  +D
Sbjct: 310 KQNDFSVTLSGSVD 323



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1877 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1936

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1937 LAEFEGDFSLEGLRLWK 1953


>AF035537-1|AAB88486.1| 3052|Homo sapiens DNA polymerase zeta protein.
          Length = 3052

 Score =  725 bits (1793), Expect = 0.0
 Identities = 363/854 (42%), Positives = 543/854 (63%), Gaps = 35/854 (4%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 2141 LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 2200

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 2201 KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 2260

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 2261 KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 2320

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 2321 DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 2380

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 2381 VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 2440

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 2441 HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 2500

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 2501 VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 2560

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXX 1218
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK SVR+GVLP         
Sbjct: 2561 NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVKPSVRKGVLPRMLEEILKT 2618

Query: 1219 XQAVKKSMKM-QNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKG 1277
               VK+SMK  + D A+ + + +RQLGLKLIANVT+GYT+ANFSGRMPC+EV DS+V K 
Sbjct: 2619 RFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKA 2678

Query: 1278 RETLERAIKLVRENTTWNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPV 1337
            RETLERAIKLV +   W A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV
Sbjct: 2679 RETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPV 2738

Query: 1338 ALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCE 1397
             LK EKVY PC+LQTKKRYVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  
Sbjct: 2739 KLKFEKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKL 2798

Query: 1398 LFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGM 1457
            LF   D+S++K+ V+    +L E    + +  F +EY G   Y+PGA  P  E+ +++  
Sbjct: 2799 LFETRDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLT 2858

Query: 1458 KDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXX 1517
             DRR+ P+ G RV +++  G PGVPL++L R P E+ +D +LR +  YY T+        
Sbjct: 2859 YDRRSEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLAR 2918

Query: 1518 XXXXXGVDVFKWWNELG--YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVC 1573
                 G+DVF W++EL   +  T+  R + +   G I +Y +   C VC    + +  +C
Sbjct: 2919 IFSLIGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGIC 2976

Query: 1574 PQC-AHTQRACVVL 1586
             +C +  Q   V+L
Sbjct: 2977 SKCRSQPQHVAVIL 2990



 Score =  149 bits (361), Expect = 8e-35
 Identities = 88/248 (35%), Positives = 144/248 (58%), Gaps = 38/248 (15%)

Query: 66  IAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGLIKQAVE 125
           +A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P ++K+  E
Sbjct: 1   MAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICE 60

Query: 126 LFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN------ 179
           L  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN      
Sbjct: 61  LLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSNTLHATG 118

Query: 180 ------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQRIGKGDG 218
                       + L+  +++ + S          S+C  + D + + I+NR  I    G
Sbjct: 119 SCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPHSTCELQVDAVXADILNRLDIEAQIG 178

Query: 219 IENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK-------FENIFA 270
             NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++        +N F+
Sbjct: 179 -GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFS 237

Query: 271 VKLSNKID 278
           V LS  +D
Sbjct: 238 VTLSGSVD 245



 Score = 36.7 bits (81), Expect = 0.70
 Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 4/77 (5%)

Query: 661  IFTPTVKPPTKNE-MET--KYKIPKTKQVQPFFSDYKDVGDKV-EIGQLVLKLHSNLSRD 716
            I  P + PP++ E M T   + + +T   +PF S+  DV +K  EIG  +L + + L+ D
Sbjct: 1799 ILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLAND 1858

Query: 717  QKPFEKVLETESIENWR 733
               FE     E +  W+
Sbjct: 1859 LAEFEGDFSLEGLRLWK 1875


>AB209256-1|BAD92493.1|  750|Homo sapiens REV3-like, catalytic subunit
            of DNA polymerase zeta variant protein.
          Length = 750

 Score =  358 bits (880), Expect = 1e-97
 Identities = 180/462 (38%), Positives = 288/462 (62%), Gaps = 27/462 (5%)

Query: 764  IQPVVRPPTSEQV--KKWINEQKALQLLSQFSSEQAISKNMDDFNNSQALGLNEDEINSS 821
            + P+   P ++++  KK  N     ++L   +  Q  + N      SQ  G + +     
Sbjct: 280  LSPLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF 339

Query: 822  IVSIENCESADFL------TSMVIEVHTSVRGDMHPDPAVDPIKAVFYSVINDCPNNHFL 875
             VSI+N + A  L      T + +E+H   R D+ PDP  DPI A+FY + +D P     
Sbjct: 340  KVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTE 399

Query: 876  KKSLTGIIVVDSSSRKYLDGCVFNVPVI-----------YVSNEIETIDEVIKLVNIHDP 924
            K  LTG+IV+D     +     +  P++           Y ++E     E+  ++  +DP
Sbjct: 400  KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDP 459

Query: 925  DIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDY------EGRI 978
            DI+ GYEI+M+SWGY+L+RA  L +D+ + +SR+ +   + R+     +Y      E  I
Sbjct: 460  DILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINI 519

Query: 979  IGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKMLRWIPVE 1038
            +GR+  N+WR+ R+E+AL++Y+FEN  + VL++R P +++  LSDW+ +++ + RW  V+
Sbjct: 520  VGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVD 579

Query: 1039 YYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAARPLNLIA 1098
            +Y++++ G ++ML++LD+I +TSE+ARLFG+Q+  VL+RGSQ+RVES+MLR A+P+N I 
Sbjct: 580  HYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIP 639

Query: 1099 LSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQ 1158
            ++P+++QRS MRAP+ +PLI EPESRFYS+ V+VLDFQSLYPS++IAYNYCFSTC+G V+
Sbjct: 640  VTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVE 699

Query: 1159 NINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVK 1200
            N+     ++FG   LR+P   L  +  +  +  SP G+ FVK
Sbjct: 700  NLGKYDEFKFGCTSLRVPPDLLYQVRHDITV--SPNGVAFVK 739


>AF004713-1|AAF21598.1|  356|Homo sapiens DNA-dependent DNA polymerase
            protein.
          Length = 356

 Score =  262 bits (641), Expect = 1e-68
 Identities = 127/296 (42%), Positives = 187/296 (63%), Gaps = 7/296 (2%)

Query: 1296 AKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPVALKLEKVYQPCILQTKKR 1355
            A+V+YGDTDSMFVL+ G ++ ++F+IGQ+IA+AVTA NP PV LK EKVY PC+LQTKKR
Sbjct: 1    ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKR 60

Query: 1356 YVGFMFESPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCELFTHGDMSVVKRLVKATL 1415
            YVG+M+E+ DQ+ P ++AKGIETVRRD CPA  K+L +SL  LF   D+S++K+ V+   
Sbjct: 61   YVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQC 120

Query: 1416 SRLAETSLPVHELFFTREYHGQAGYRPGASAPPNEIAKRIGMKDRRAIPRTGWRVSWLVT 1475
             +L E    + +  F +EY G   Y+PGA  P  E+ +++   DRR+ P+ G RV +++ 
Sbjct: 121  MKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVII 180

Query: 1476 CGAPGVPLVRLARTPQELTRDRSLRPHVAYYATRVXXXXXXXXXXXXGVDVFKWWNELG- 1534
             G PGVPL++L R P E+ +D +LR +  YY T+             G+DVF W++EL  
Sbjct: 181  YGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIGIDVFSWYHELPR 240

Query: 1535 -YNRTAQQREQTQ--SGGIEKYMSRERCAVCGVRTIVRSAVCPQC-AHTQRACVVL 1586
             +  T+  R + +   G I +Y +   C VC    + +  +C +C +  Q   V+L
Sbjct: 241  IHKATSSSRSEPEGRKGTISQYFTTLHCPVCD--DLTQHGICSKCRSQPQHVAVIL 294


>BC008800-1|AAH08800.1| 1107|Homo sapiens polymerase (DNA directed),
            delta 1, catalytic subunit 125kDa protein.
          Length = 1107

 Score =  250 bits (613), Expect = 2e-65
 Identities = 182/601 (30%), Positives = 283/601 (47%), Gaps = 41/601 (6%)

Query: 919  VNIHDPDIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDYEGR- 977
            + I DPD++ GY I+     Y++ RA+ L +     L R+       R    +S   GR 
Sbjct: 385  IRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRR 444

Query: 978  ------IIGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKM 1031
                  ++GRV  ++ ++   E  L SY+     +  L E+     ++ ++D      + 
Sbjct: 445  DTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQT 504

Query: 1032 LRWIPVEYYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAA 1091
             R + V Y L      +R+L++L ++    E+AR+ G+    +LSRG Q +V S +LR A
Sbjct: 505  RRRLAV-YCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA 563

Query: 1092 RPLNLIALSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFS 1151
                L  L P +K         T   + EP   +Y  P+  LDF SLYPS+M+A+N C++
Sbjct: 564  MHEGL--LMPVVKSEGG--EDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYT 619

Query: 1152 TCIGRVQNINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXX 1211
            T +         TA + G             L ++  I  +P G  FVKTSVR+G+LP  
Sbjct: 620  TLL------RPGTAQKLG-------------LTEDQFIR-TPTGDEFVKTSVRKGLLPQI 659

Query: 1212 XXXXXXXXQAVKKSMKMQNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVAD 1271
                    +  K  +  + D   ++ +  RQL LK+ AN  YG+T A   G++PC+E++ 
Sbjct: 660  LENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQ 718

Query: 1272 SVVAKGRETLERAIKLVRENTT------WNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQI 1325
            SV   GR+ +E+  +LV    T       +AKV+YGDTDS+       S  EA  +G++ 
Sbjct: 719  SVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREA 778

Query: 1326 ADAVTADNPPPVALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCP 1385
            AD V+   P P+ L+ EKVY P +L +KKRY G +F S        + KG+E VRRD CP
Sbjct: 779  ADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCP 838

Query: 1386 AGVKLLRQSLCELFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGAS 1445
                L+  SL  L    D        +  +S L    + + +L  T+E    A    G  
Sbjct: 839  LVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQ 898

Query: 1446 APPNEIAKRIGMKDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAY 1505
            A   E+A+R+  +D  + P  G RV +++   A GV     +  P     + SL     Y
Sbjct: 899  AHV-ELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPL-FVLEHSLPIDTQY 956

Query: 1506 Y 1506
            Y
Sbjct: 957  Y 957



 Score = 72.9 bits (171), Expect = 9e-12
 Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 15/157 (9%)

Query: 23  VPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEPQLLYQIAASLDKALNIAMKQAT 82
           VPVLR FG   +G+  C HIHG  PYFY P P     P    +    L + LN+A+ + +
Sbjct: 122 VPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAP-----PGFGPEHMGDLQRELNLAISRDS 176

Query: 83  SSNQH-----VYKISLVKGLPFYGYHDK-EHLYLKVFLYRPGLIKQAVELFSSG---AIL 133
              +      V  + L      +GYH      +L++ +  P L+  A  L   G   A L
Sbjct: 177 RGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGL 236

Query: 134 G-QTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQF 169
           G  +F P+E++++F ++F +D ++ G + ++L + ++
Sbjct: 237 GTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKY 273


>AY129569-1|AAM76971.1| 1107|Homo sapiens polymerase (DNA directed),
            delta 1, catalytic subunit protein.
          Length = 1107

 Score =  250 bits (613), Expect = 2e-65
 Identities = 182/601 (30%), Positives = 283/601 (47%), Gaps = 41/601 (6%)

Query: 919  VNIHDPDIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDYEGR- 977
            + I DPD++ GY I+     Y++ RA+ L +     L R+       R    +S   GR 
Sbjct: 385  IRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRR 444

Query: 978  ------IIGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKM 1031
                  ++GRV  ++ ++   E  L SY+     +  L E+     ++ ++D      + 
Sbjct: 445  DTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQT 504

Query: 1032 LRWIPVEYYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAA 1091
             R + V Y L      +R+L++L ++    E+AR+ G+    +LSRG Q +V S +LR A
Sbjct: 505  RRRLAV-YCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA 563

Query: 1092 RPLNLIALSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFS 1151
                L  L P +K         T   + EP   +Y  P+  LDF SLYPS+M+A+N C++
Sbjct: 564  MHEGL--LMPVVKSEGG--EDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYT 619

Query: 1152 TCIGRVQNINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXX 1211
            T +         TA + G             L ++  I  +P G  FVKTSVR+G+LP  
Sbjct: 620  TLL------RPGTAQKLG-------------LTEDQFIR-TPTGDEFVKTSVRKGLLPQI 659

Query: 1212 XXXXXXXXQAVKKSMKMQNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVAD 1271
                    +  K  +  + D   ++ +  RQL LK+ AN  YG+T A   G++PC+E++ 
Sbjct: 660  LENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQ 718

Query: 1272 SVVAKGRETLERAIKLVRENTT------WNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQI 1325
            SV   GR+ +E+  +LV    T       +AKV+YGDTDS+       S  EA  +G++ 
Sbjct: 719  SVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREA 778

Query: 1326 ADAVTADNPPPVALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCP 1385
            AD V+   P P+ L+ EKVY P +L +KKRY G +F S        + KG+E VRRD CP
Sbjct: 779  ADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCP 838

Query: 1386 AGVKLLRQSLCELFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGAS 1445
                L+  SL  L    D        +  +S L    + + +L  T+E    A    G  
Sbjct: 839  LVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQ 898

Query: 1446 APPNEIAKRIGMKDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAY 1505
            A   E+A+R+  +D  + P  G RV +++   A GV     +  P     + SL     Y
Sbjct: 899  AHV-ELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPL-FVLEHSLPIDTQY 956

Query: 1506 Y 1506
            Y
Sbjct: 957  Y 957



 Score = 72.9 bits (171), Expect = 9e-12
 Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 15/157 (9%)

Query: 23  VPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEPQLLYQIAASLDKALNIAMKQAT 82
           VPVLR FG   +G+  C HIHG  PYFY P P     P    +    L + LN+A+ + +
Sbjct: 122 VPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAP-----PGFGPEHMGDLQRELNLAISRDS 176

Query: 83  SSNQH-----VYKISLVKGLPFYGYHDK-EHLYLKVFLYRPGLIKQAVELFSSG---AIL 133
              +      V  + L      +GYH      +L++ +  P L+  A  L   G   A L
Sbjct: 177 RGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGL 236

Query: 134 G-QTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQF 169
           G  +F P+E++++F ++F +D ++ G + ++L + ++
Sbjct: 237 GTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKY 273


>M81735-1|AAA35768.1| 1107|Homo sapiens DNA polymerase delta protein.
          Length = 1107

 Score =  249 bits (610), Expect = 6e-65
 Identities = 182/601 (30%), Positives = 282/601 (46%), Gaps = 41/601 (6%)

Query: 919  VNIHDPDIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDYEGR- 977
            + I DPD++ GY I+     Y++ RA+ L +     L R+       R    +S   GR 
Sbjct: 385  IRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRR 444

Query: 978  ------IIGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKM 1031
                  ++GRV  ++ ++   E  L SY+     +  L E+     ++ ++D      + 
Sbjct: 445  DTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQT 504

Query: 1032 LRWIPVEYYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAA 1091
             R + V Y L      +R+L++L ++    E+AR+ G+    +LSRG Q +V S +LR A
Sbjct: 505  RRRLAV-YCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA 563

Query: 1092 RPLNLIALSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFS 1151
                L  L P +K         T   + EP   +Y  P+  LDF SLYPS+M+A+N C++
Sbjct: 564  MHEGL--LMPVVKSEGG--EDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYT 619

Query: 1152 TCIGRVQNINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXX 1211
            T +         TA + G             L ++  I  +P G  FVKTSVR+G+LP  
Sbjct: 620  TLL------RPGTAQKLG-------------LTEDQFIR-TPTGDEFVKTSVRKGLLPQI 659

Query: 1212 XXXXXXXXQAVKKSMKMQNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVAD 1271
                    +  K  +  + D   ++ +  RQL LK+ AN  YG+T A   G++PC+E++ 
Sbjct: 660  LENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQ 718

Query: 1272 SVVAKGRETLERAIKLVRENTT------WNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQI 1325
            SV   GR+ +E+  +LV    T       +AKV+YGDTDS+       S  EA  +G + 
Sbjct: 719  SVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGGEA 778

Query: 1326 ADAVTADNPPPVALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCP 1385
            AD V+   P P+ L+ EKVY P +L +KKRY G +F S        + KG+E VRRD CP
Sbjct: 779  ADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCP 838

Query: 1386 AGVKLLRQSLCELFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGAS 1445
                L+  SL  L    D        +  +S L    + + +L  T+E    A    G  
Sbjct: 839  LVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQ 898

Query: 1446 APPNEIAKRIGMKDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAY 1505
            A   E+A+R+  +D  + P  G RV +++   A GV     +  P     + SL     Y
Sbjct: 899  AHV-ELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPL-FVLEHSLPIDTQY 956

Query: 1506 Y 1506
            Y
Sbjct: 957  Y 957



 Score = 73.7 bits (173), Expect = 5e-12
 Identities = 45/153 (29%), Positives = 78/153 (50%), Gaps = 7/153 (4%)

Query: 23  VPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEPQLLYQIAASLDKALNIAMKQAT 82
           VPVLR FG   +G+  C HIHG  PYFY P P     P+ +  +   L+ A+N   +   
Sbjct: 122 VPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAP-PGFGPEHMGDLQRELNLAINRDSRGGR 180

Query: 83  S-SNQHVYKISLVKGLPFYGYHDK-EHLYLKVFLYRPGLIKQAVELFSSG---AILG-QT 136
             +   V  + L      +GYH      +L++ +  P L+  A  L   G   A LG  +
Sbjct: 181 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS 240

Query: 137 FQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQF 169
           F P+E++++F ++F +D ++ G + ++L + ++
Sbjct: 241 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKY 273


>M80397-1|AAA58439.1| 1107|Homo sapiens DNA polymerase-delta
            catalytic-subunit protein.
          Length = 1107

 Score =  248 bits (608), Expect = 1e-64
 Identities = 181/601 (30%), Positives = 283/601 (47%), Gaps = 41/601 (6%)

Query: 919  VNIHDPDIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDYEGR- 977
            + I DPD++ GY I+     Y++ RA+ L +     L R+       R    +S   GR 
Sbjct: 385  IRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRR 444

Query: 978  ------IIGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKM 1031
                  ++GRV  ++ ++   E  L S++     +  L E+     ++ ++D      + 
Sbjct: 445  DTKVVSMVGRVQMDMLQVLLREYKLRSHTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQT 504

Query: 1032 LRWIPVEYYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAA 1091
             R + V Y L      +R+L++L ++    E+AR+ G+    +LSRG Q +V S +LR A
Sbjct: 505  RRRLAV-YCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA 563

Query: 1092 RPLNLIALSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFS 1151
                L  L P +K         T   + EP   +Y  P+  LDF SLYPS+M+A+N C++
Sbjct: 564  MHEGL--LMPVVKSEGG--EDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYT 619

Query: 1152 TCIGRVQNINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXX 1211
            T +         TA + G             L ++  I  +P G  FVKTSVR+G+LP  
Sbjct: 620  TLL------RPGTAQKLG-------------LTEDQFIR-TPTGDEFVKTSVRKGLLPQI 659

Query: 1212 XXXXXXXXQAVKKSMKMQNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVAD 1271
                    +  K  +  + D   ++ +  RQL LK+ AN  YG+T A   G++PC+E++ 
Sbjct: 660  LENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQ 718

Query: 1272 SVVAKGRETLERAIKLVRENTT------WNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQI 1325
            SV   GR+ +E+  +LV    T       +AKV+YGDTDS+       S  EA  +G++ 
Sbjct: 719  SVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREA 778

Query: 1326 ADAVTADNPPPVALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCP 1385
            AD V+   P P+ L+ EKVY P +L +KKRY G +F S        + KG+E VRRD CP
Sbjct: 779  ADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCP 838

Query: 1386 AGVKLLRQSLCELFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGAS 1445
                L+  SL  L    D        +  +S L    + + +L  T+E    A    G  
Sbjct: 839  LVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQ 898

Query: 1446 APPNEIAKRIGMKDRRAIPRTGWRVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAY 1505
            A   E+A+R+  +D  + P  G RV +++   A GV     +  P     + SL     Y
Sbjct: 899  AHV-ELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPL-FVLEHSLPIDTQY 956

Query: 1506 Y 1506
            Y
Sbjct: 957  Y 957



 Score = 72.9 bits (171), Expect = 9e-12
 Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 15/157 (9%)

Query: 23  VPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEPQLLYQIAASLDKALNIAMKQAT 82
           VPVLR FG   +G+  C HIHG  PYFY P P     P    +    L + LN+A+ + +
Sbjct: 122 VPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAP-----PGFGPEHMGDLQRELNLAISRDS 176

Query: 83  SSNQH-----VYKISLVKGLPFYGYHDK-EHLYLKVFLYRPGLIKQAVELFSSG---AIL 133
              +      V  + L      +GYH      +L++ +  P L+  A  L   G   A L
Sbjct: 177 RGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGL 236

Query: 134 G-QTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQF 169
           G  +F P+E++++F ++F +D ++ G + ++L + ++
Sbjct: 237 GTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKY 273


>AB209560-1|BAD92797.1| 1011|Homo sapiens polymerase (DNA directed),
            delta 1, catalytic subunit 125kDa variant protein.
          Length = 1011

 Score =  235 bits (576), Expect = 7e-61
 Identities = 169/549 (30%), Positives = 262/549 (47%), Gaps = 40/549 (7%)

Query: 919  VNIHDPDIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDYEGR- 977
            + I DPD++ GY I+     Y++ RA+ L +     L R+       R    +S   GR 
Sbjct: 387  IRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRR 446

Query: 978  ------IIGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKM 1031
                  ++GRV  ++ ++   E  L SY+     +  L E+     ++ ++D      + 
Sbjct: 447  DTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQT 506

Query: 1032 LRWIPVEYYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAA 1091
             R + V Y L      +R+L++L ++    E+AR+ G+    +LSRG Q +V S +LR A
Sbjct: 507  RRRLAV-YCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA 565

Query: 1092 RPLNLIALSPTIKQRSTMRAPETLPLIFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFS 1151
                L  L P +K         T   + EP   +Y  P+  LDF SLYPS+M+A+N C++
Sbjct: 566  MHEGL--LMPVVKSEGG--EDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYT 621

Query: 1152 TCIGRVQNINGETAYEFGAWRLRIPRSKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXX 1211
            T +         TA + G             L ++  I  +P G  FVKTSVR+G+LP  
Sbjct: 622  TLL------RPGTAQKLG-------------LTEDQFIR-TPTGDEFVKTSVRKGLLPQI 661

Query: 1212 XXXXXXXXQAVKKSMKMQNDEAVKKAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVAD 1271
                    +  K  +  + D   ++ +  RQL LK+ AN  YG+T A   G++PC+E++ 
Sbjct: 662  LENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQ 720

Query: 1272 SVVAKGRETLERAIKLVRENTT------WNAKVIYGDTDSMFVLVPGRSRLEAFEIGQQI 1325
            SV   GR+ +E+  +LV    T       +AKV+YGDTDS+       S  EA  +G++ 
Sbjct: 721  SVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREA 780

Query: 1326 ADAVTADNPPPVALKLEKVYQPCILQTKKRYVGFMFESPDQEKPTYEAKGIETVRRDGCP 1385
            AD V+   P P+ L+ EKVY P +L +KKRY G +F S        + KG+E VRRD CP
Sbjct: 781  ADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCP 840

Query: 1386 AGVKLLRQSLCELFTHGDMSVVKRLVKATLSRLAETSLPVHELFFTREYHGQAGYRPGAS 1445
                L+  SL  L    D        +  +S L    + + +L  T+E    A    G  
Sbjct: 841  LVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQ 900

Query: 1446 APPNEIAKR 1454
            A   E+A+R
Sbjct: 901  AHV-ELAER 908



 Score = 72.9 bits (171), Expect = 9e-12
 Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 15/157 (9%)

Query: 23  VPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEPQLLYQIAASLDKALNIAMKQAT 82
           VPVLR FG   +G+  C HIHG  PYFY P P     P    +    L + LN+A+ + +
Sbjct: 124 VPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAP-----PGFGPEHMGDLQRELNLAISRDS 178

Query: 83  SSNQH-----VYKISLVKGLPFYGYHDK-EHLYLKVFLYRPGLIKQAVELFSSG---AIL 133
              +      V  + L      +GYH      +L++ +  P L+  A  L   G   A L
Sbjct: 179 RGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGL 238

Query: 134 G-QTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQF 169
           G  +F P+E++++F ++F +D ++ G + ++L + ++
Sbjct: 239 GTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKY 275


>DQ234348-1|ABB29977.1| 1133|Homo sapiens DNA-directed polymerase
            delta 1 protein.
          Length = 1133

 Score =  232 bits (568), Expect = 7e-60
 Identities = 197/696 (28%), Positives = 311/696 (44%), Gaps = 63/696 (9%)

Query: 919  VNIHDPDIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRITEKNRQKRWMKNESDYEGR- 977
            + I DPD++ GY I+     Y++ RA+ L +     L R+       R    +S   GR 
Sbjct: 385  IRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRR 444

Query: 978  ------IIGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSYAQLSDWWCDESKM 1031
                  ++GRV  ++ ++   E  L SY+     +  L E+     ++ ++D      + 
Sbjct: 445  DTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQT 504

Query: 1032 LRWIPVEYYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRGSQFRVESLMLRAA 1091
             R + V Y L      +R+L++L ++    E+AR+ G+    +LSRG Q +V S +LR A
Sbjct: 505  RRRLAV-YCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA 563

Query: 1092 RPLNLI----------------ALSPTIKQRSTMRAPETLPLI-FEP-----ESRFYSDP 1129
                L+                 + P    R   RA     L+   P       R+Y  P
Sbjct: 564  MHEGLLMPVVKSEGGEDYTGATVIGPLKGVRPQDRAGAAWELLALTPGRGCSPPRYYDVP 623

Query: 1130 VIVLDFQSLYPSMMIAYNYCFSTCIGRVQNINGETAYEFGAWRLRIPRSKLEALVKNSLI 1189
            +  L F SLYPS+M+A+N C++T +         TA + G             L ++  I
Sbjct: 624  IATLGFSSLYPSIMMAHNLCYTTLL------RPGTAQKLG-------------LTEDQFI 664

Query: 1190 HWSPVGIGFVKTSVRRGVLPXXXXXXXXXXQAVKKSMKMQNDEAVKKAMHSRQLGLKLIA 1249
              +P G  FVKTSVR+G+LP          +  K  +  + D   ++ +  RQLGLK+ A
Sbjct: 665  R-TPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLGLKVSA 723

Query: 1250 NVTYGYTAANFSGRMPCVEVADSVVAKGRETLERAIKLVRENTT------WNAKVIYGDT 1303
            N  YG+T A   G++PC+E++ SV   GR+ +E+  +LV    T       +AKV+YGDT
Sbjct: 724  NSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDT 782

Query: 1304 DSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPVALKLEKVYQPCILQTKKRYVGFMFES 1363
            DS+       S  EA  +G++ AD V+   P P+ L+ EKVY P +L +KKRY G +F S
Sbjct: 783  DSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSS 842

Query: 1364 PDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCELFTHGDMSVVKRLVKATLSRLAETSL 1423
                    + KG+E VRRD CP    L+  SL  L    D        +  +S L    +
Sbjct: 843  RPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRI 902

Query: 1424 PVHELFFTREYHGQAGYRPGASAPPNEIAKRIGMKDRRAIPRTGWRVSWLVTCGAPGVPL 1483
             + +L  T+E    A    G  A   E+A+R+  +D  + P  G RV +++   A GV  
Sbjct: 903  DISQLVITKELTRAASDYAGKQAHV-ELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAA 961

Query: 1484 VRLARTPQELTRDRSLRPHVAYYATRVXXXXXXXXXXXXGVDVFKWWNELGYNRTAQQRE 1543
               +  P     + SL     YY  +               +       L  + T ++  
Sbjct: 962  YMKSEDPL-FVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRRKTV 1020

Query: 1544 QT-QSGGIEKYMSRERCAVCGVRTIV--RSAVCPQC 1576
             T + GG+  +  R  C + G RT++  + AVC  C
Sbjct: 1021 LTGKVGGLLAFAKRRNCCI-GCRTVLSHQGAVCEFC 1055



 Score = 72.9 bits (171), Expect = 9e-12
 Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 15/157 (9%)

Query: 23  VPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEPQLLYQIAASLDKALNIAMKQAT 82
           VPVLR FG   +G+  C HIHG  PYFY P P     P    +    L + LN+A+ + +
Sbjct: 122 VPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAP-----PGFGPEHMGDLQRELNLAISRDS 176

Query: 83  SSNQH-----VYKISLVKGLPFYGYHDK-EHLYLKVFLYRPGLIKQAVELFSSG---AIL 133
              +      V  + L      +GYH      +L++ +  P L+  A  L   G   A L
Sbjct: 177 RGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGL 236

Query: 134 G-QTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQF 169
           G  +F P+E++++F ++F +D ++ G + ++L + ++
Sbjct: 237 GTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKY 273


>BC035823-1|AAH35823.1|  608|Homo sapiens Similar to REV3-like,
           catalytic subunit of DNA polymerase zeta RAD54 like (S.
           c protein.
          Length = 608

 Score =  213 bits (520), Expect = 4e-54
 Identities = 118/314 (37%), Positives = 183/314 (58%), Gaps = 39/314 (12%)

Query: 1   MTKPTAGLDVTYSEFRGTDIKQVPVLRIFGPAKDGYKACLHIHGVFPYFYIPCPTQNPEP 60
           M  P  GLD   S      +K+VPV+R+FG    G K CLH+HG+FPY Y+P      +P
Sbjct: 13  MASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQP 72

Query: 61  Q-LLYQIAASLDKALNIAMKQATSSNQHVYKISLVKGLPFYGYHDKEHLYLKVFLYRPGL 119
           +  L Q+A S+D+ALN+A+   +S+ QHV+K+SLV G+PFYGYH+KE  ++K++LY P +
Sbjct: 73  ESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTM 132

Query: 120 IKQAVELFSSGAILGQTFQPHESHLNFTLQFFIDFNLFGMSDIDLQSVQFRKSGFSQKSN 179
           +K+  EL  SGAI+ + +QPHE+H+ + LQ FID+NL+GM+ I+L +V+FRK+   +KSN
Sbjct: 133 VKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAVKFRKA--RRKSN 190

Query: 180 ------------------EVLYDTKENTLTS---------ESSCHYEADCMASHIINRQR 212
                             + L+  +++ + S         +S+C  E D +A+ I+NR  
Sbjct: 191 TLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLD 250

Query: 213 IGKGDGIENPGLEEVWNQELERRKQLN-MSLASKSLSQGLTSLKQVETDSHYK------- 264
           I    G  NPGL+ +W  E +RR+  N  S  S+  SQ    +   E++  ++       
Sbjct: 251 IEAQIG-GNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEIL 309

Query: 265 FENIFAVKLSNKID 278
            +N F+V LS  +D
Sbjct: 310 KQNDFSVTLSGSVD 323


>AY275833-1|AAP13534.1| 1462|Homo sapiens polymerase (DNA directed),
            alpha protein.
          Length = 1462

 Score =  101 bits (242), Expect = 2e-20
 Identities = 138/638 (21%), Positives = 251/638 (39%), Gaps = 62/638 (9%)

Query: 899  NVPVIYVSNEIETIDEVIKLVNIHDPDIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRI 958
            NV V   + E   +   +  V+  DPDI+ G+ I       +L+R  +        + R+
Sbjct: 606  NVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRL 665

Query: 959  TEKNRQKRWMKNESDYEGRIIGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSY 1018
               N  K   ++         GR+I +V    +  +   SY     + ++L         
Sbjct: 666  KRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPM 725

Query: 1019 AQLSDWWCDESKMLRWIPVEYYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRG 1078
              + + + + S++L  +  E+        ++++ +L+++    ++  + G      L  G
Sbjct: 726  ENIQNMYSESSQLLYLL--EHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGG 783

Query: 1079 SQFRVESLMLRAARPLNLIALSPTI---------------------KQRSTMRAPETLPL 1117
               R E L+L A    N I     I                      ++   +A     L
Sbjct: 784  RSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGL 843

Query: 1118 IFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQNINGETAYEFGAWRLRIPR 1177
            + +P+  FY   +++LDF SLYPS++  +N CF+T    VQ +  E              
Sbjct: 844  VLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTT----VQRVASEA------------- 886

Query: 1178 SKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXXXQAVKKSMKMQ--NDEAVK 1235
             K+    +   I   P        S+  G+LP          + VK+ MK Q  N + + 
Sbjct: 887  QKVTEDGEQEQIPELP------DPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLIL 940

Query: 1236 KAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKGRETLERAIKLVRENTTWN 1295
            +    RQ  LKL AN  YG    ++S R     +A  V  KGRE L    ++V++    N
Sbjct: 941  Q-YDIRQKALKLTANSMYGCLGFSYS-RFYAKPLAALVTYKGREILMHTKEMVQK---MN 995

Query: 1296 AKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPVALKLEKVYQPCILQTKKR 1355
             +VIYGDTDS+ +     +  E F++G ++   V       + + ++ V++  +L  KK+
Sbjct: 996  LEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVN-KLYKLLEIDIDGVFKSLLLLKKKK 1054

Query: 1356 YVGFMFE--SPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCELFTHGDMSVVKRLVKA 1413
            Y   + E  S        E KG++ VRRD C          + ++ +      +   ++ 
Sbjct: 1055 YAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQK 1114

Query: 1414 TLSRLAET----SLPVHELFFTREY-HGQAGYRPGASAPPNEIAKRIGMKDRRAIPRTGW 1468
             L  + E     S+PV +    +        Y    S P   +A  I  +  R + + G 
Sbjct: 1115 RLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKV-KAGD 1173

Query: 1469 RVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYY 1506
             VS+++      +   + A  P++L +  +L     YY
Sbjct: 1174 TVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYY 1211


>X06745-1|CAA29920.1| 1462|Homo sapiens protein ( Human mRNA for DNA
            polymerase alpha-subunit. ).
          Length = 1462

 Score =  100 bits (240), Expect = 4e-20
 Identities = 138/638 (21%), Positives = 252/638 (39%), Gaps = 62/638 (9%)

Query: 899  NVPVIYVSNEIETIDEVIKLVNIHDPDIMCGYEIEMNSWGYVLERAEILGLDVLKDLSRI 958
            NV V   + E   +   +  V+  DPDI+ G+ I       +L+R  +        + R+
Sbjct: 606  NVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRL 665

Query: 959  TEKNRQKRWMKNESDYEGRIIGRVIFNVWRLFRHELALSSYSFENCMYEVLNERVPSYSY 1018
               N  K   ++         GR+I +V    +  +   SY     + ++L         
Sbjct: 666  KRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPM 725

Query: 1019 AQLSDWWCDESKMLRWIPVEYYLTKLSGTVRMLQKLDIINRTSELARLFGLQWWEVLSRG 1078
              + + + + S++L  +  E+        ++++ +L+++    ++  + G      L  G
Sbjct: 726  ENIQNMYSESSQLLYLL--EHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGG 783

Query: 1079 SQFRVESLMLRAARPLNLIALSPTIKQRSTMRA---PETLP------------------L 1117
               R E L+L A    N I     I ++   +     E +                   L
Sbjct: 784  RSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKGAYAGGL 843

Query: 1118 IFEPESRFYSDPVIVLDFQSLYPSMMIAYNYCFSTCIGRVQNINGETAYEFGAWRLRIPR 1177
            + +P+  FY   +++LDF SLYPS++  +N CF+T    VQ +  E              
Sbjct: 844  VLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTT----VQRVASEA------------- 886

Query: 1178 SKLEALVKNSLIHWSPVGIGFVKTSVRRGVLPXXXXXXXXXXQAVKKSMKMQ--NDEAVK 1235
             K+    +   I   P        S+  G+LP          + VK+ MK Q  N + + 
Sbjct: 887  QKVTEDGEQEQIPELP------DPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLIL 940

Query: 1236 KAMHSRQLGLKLIANVTYGYTAANFSGRMPCVEVADSVVAKGRETLERAIKLVRENTTWN 1295
            +    RQ  LKL AN  YG    ++S R     +A  V  KGRE L    ++V++    N
Sbjct: 941  Q-YDIRQKALKLTANSMYGCLGFSYS-RFYAKPLAALVTYKGREILMHTKEMVQK---MN 995

Query: 1296 AKVIYGDTDSMFVLVPGRSRLEAFEIGQQIADAVTADNPPPVALKLEKVYQPCILQTKKR 1355
             +VIYGDTDS+ +     +  E F++G ++   V       + + ++ V++  +L  KK+
Sbjct: 996  LEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVN-KLYKLLEIDIDGVFKSLLLLKKKK 1054

Query: 1356 YVGFMFE--SPDQEKPTYEAKGIETVRRDGCPAGVKLLRQSLCELFTHGDMSVVKRLVKA 1413
            Y   + E  S        E KG++ VRRD C          + ++ +      +   ++ 
Sbjct: 1055 YAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQK 1114

Query: 1414 TLSRLAET----SLPVHELFFTREY-HGQAGYRPGASAPPNEIAKRIGMKDRRAIPRTGW 1468
             L  + E     S+PV +    +        Y    S P   +A  I  +  R + + G 
Sbjct: 1115 RLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKV-KAGD 1173

Query: 1469 RVSWLVTCGAPGVPLVRLARTPQELTRDRSLRPHVAYY 1506
             VS+++      +   + A  P++L +  +L     YY
Sbjct: 1174 TVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYY 1211


>AF051164-1|AAC83554.1| 1147|Homo sapiens heart muscle inducible
           nitric oxide synthase protein.
          Length = 1147

 Score = 37.1 bits (82), Expect = 0.53
 Identities = 30/104 (28%), Positives = 51/104 (49%), Gaps = 9/104 (8%)

Query: 178 SNEVLYDTKENTLTSESSCHYEADCMASHIINRQRIGKGDGIENPGLEEVWNQELERRKQ 237
           + E+ +DT  +  TS+ SC  +  CM S I+N + + +G   +   +EE+  Q +E   Q
Sbjct: 89  NGEIFHDTLHHKATSDISCKSKL-CMGS-IMNSKSLTRGPRDKPTPVEELLPQAIEFINQ 146

Query: 238 LNMSLASKSLSQGLTSL----KQVETDSHYKF---ENIFAVKLS 274
              S     + + L  L    K++ET   Y+    E IFA K++
Sbjct: 147 YYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMA 190


>AF049656-1|AAC83553.1| 1147|Homo sapiens inducible nitric oxide
           synthase protein.
          Length = 1147

 Score = 37.1 bits (82), Expect = 0.53
 Identities = 30/104 (28%), Positives = 51/104 (49%), Gaps = 9/104 (8%)

Query: 178 SNEVLYDTKENTLTSESSCHYEADCMASHIINRQRIGKGDGIENPGLEEVWNQELERRKQ 237
           + E+ +DT  +  TS+ SC  +  CM S I+N + + +G   +   +EE+  Q +E   Q
Sbjct: 89  NGEIFHDTLHHKATSDISCKSKL-CMGS-IMNSKSLTRGPRDKPTPVEELLPQAIEFINQ 146

Query: 238 LNMSLASKSLSQGLTSL----KQVETDSHYKF---ENIFAVKLS 274
              S     + + L  L    K++ET   Y+    E IFA K++
Sbjct: 147 YYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMA 190


>BC034992-1|AAH34992.1|  201|Homo sapiens sorting nexin 10 protein.
          Length = 201

 Score = 36.3 bits (80), Expect = 0.92
 Identities = 25/116 (21%), Positives = 52/116 (44%), Gaps = 2/116 (1%)

Query: 308 LPSKDLDLTLNRTTKMNLNEHEEEDLDTTIVDENLVLNSSMSLQYSQVLLNSEDME--LI 365
           LPSK+L   +N    ++      ED    ++   L+L+ S    + Q  LNSED+E  + 
Sbjct: 76  LPSKNLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDIEACVS 135

Query: 366 DMLHDMDQQRVEEDSIMGTPANRDQEVDMELDDAEYSRIFNDDSVCHDQNESENNG 421
                  ++ + + ++M      + E   + +D +Y    +   + H  ++S ++G
Sbjct: 136 GQTKYSVEEAIHKFALMNRRFPEEDEEGKKENDIDYDSESSSSGLGHSSDDSSSHG 191


>BC031050-1|AAH31050.1|  201|Homo sapiens sorting nexin 10 protein.
          Length = 201

 Score = 35.5 bits (78), Expect = 1.6
 Identities = 25/116 (21%), Positives = 52/116 (44%), Gaps = 2/116 (1%)

Query: 308 LPSKDLDLTLNRTTKMNLNEHEEEDLDTTIVDENLVLNSSMSLQYSQVLLNSEDME--LI 365
           LPSK+L   +N    ++      ED    ++   L+L+ S    + Q  LNSED+E  + 
Sbjct: 76  LPSKNLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSYSSLHLFLQSHLNSEDIEACVS 135

Query: 366 DMLHDMDQQRVEEDSIMGTPANRDQEVDMELDDAEYSRIFNDDSVCHDQNESENNG 421
                  ++ + + ++M      + E   + +D +Y    +   + H  ++S ++G
Sbjct: 136 GQTKYSVEEAIHKFALMNRRFPEEDEEGKKENDIDYDSESSSSGLGHSSDDSSSHG 191


>AF121860-1|AAD27833.1|  201|Homo sapiens sorting nexin 10 protein.
          Length = 201

 Score = 33.9 bits (74), Expect = 4.9
 Identities = 24/116 (20%), Positives = 51/116 (43%), Gaps = 2/116 (1%)

Query: 308 LPSKDLDLTLNRTTKMNLNEHEEEDLDTTIVDENLVLNSSMSLQYSQVLLNSEDME--LI 365
           LPSK+L   +N    ++      ED    ++   L+L+ S    + Q  LNSED+E  + 
Sbjct: 76  LPSKNLFFNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDIEACVS 135

Query: 366 DMLHDMDQQRVEEDSIMGTPANRDQEVDMELDDAEYSRIFNDDSVCHDQNESENNG 421
                  ++ + + ++M      + E   + +D +Y    +   + H  ++  ++G
Sbjct: 136 GQTKYSVEEAIHKFALMNRRFPEEDEEGKKENDIDYDSESSSSGLGHSSDDISSHG 191


>L14721-1|AAA35522.1|  957|Homo sapiens aminopeptidase A protein.
          Length = 957

 Score = 33.5 bits (73), Expect = 6.5
 Identities = 16/46 (34%), Positives = 26/46 (56%)

Query: 218 GIENPGLEEVWNQELERRKQLNMSLASKSLSQGLTSLKQVETDSHY 263
           G++N G E  WN  LE+ ++ +++   + L  GL S+K V   S Y
Sbjct: 790 GMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRY 835


>L12468-1|AAA16876.1|  957|Homo sapiens aminopeptidase A protein.
          Length = 957

 Score = 33.5 bits (73), Expect = 6.5
 Identities = 16/46 (34%), Positives = 26/46 (56%)

Query: 218 GIENPGLEEVWNQELERRKQLNMSLASKSLSQGLTSLKQVETDSHY 263
           G++N G E  WN  LE+ ++ +++   + L  GL S+K V   S Y
Sbjct: 790 GMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRY 835


>BC094770-1|AAH94770.1|  957|Homo sapiens glutamyl aminopeptidase
           (aminopeptidase A) protein.
          Length = 957

 Score = 33.5 bits (73), Expect = 6.5
 Identities = 16/46 (34%), Positives = 26/46 (56%)

Query: 218 GIENPGLEEVWNQELERRKQLNMSLASKSLSQGLTSLKQVETDSHY 263
           G++N G E  WN  LE+ ++ +++   + L  GL S+K V   S Y
Sbjct: 790 GMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRY 835


>AF163151-1|AAF42472.1| 1253|Homo sapiens dentin sialophosphoprotein
           precursor protein.
          Length = 1253

 Score = 33.5 bits (73), Expect = 6.5
 Identities = 53/272 (19%), Positives = 99/272 (36%), Gaps = 6/272 (2%)

Query: 358 NSEDMELIDMLHDMDQQRVEEDSIMGTPANR-DQEVDMELDDAEYSRIFNDDSVCHD-QN 415
           +S D +  D     D    + DS   + ++  D     +  D+  S   +D S   D ++
Sbjct: 565 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624

Query: 416 ESENNGSPLSWHDSFWDGANIPQLDGTFDNDHXXXXXXXXXXXLQLGLSRPKKKNERVNN 475
           +S  + S  S  DS  D ++    D + DN                  S     +   ++
Sbjct: 625 DSSKSESDSSDSDSKSDSSDSNSSDSS-DNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDS 683

Query: 476 PTNTDSNIDTSEIDEINVSRETADGDVCISELVRASKISKTSIENTEIKSEETFIDAVSR 535
            +++DS+  +   D  + S  +   D   S    +S  S +S  N+         D+ S 
Sbjct: 684 SSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDS-SD 742

Query: 536 ITAKQNIVKLMNKSEIYDLQNKFVPT-AGPSNKPVDCDNTEMGNSSNNELELSPDGNELG 594
            +   +     + S+  D  N    + +  S+   D  N+   N S+N  + S   N   
Sbjct: 743 SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSD 802

Query: 595 IVSFYDASKVFDDS-FNQTFLQEQTNCDDCSD 625
             +  D+S   D S  + +   + +N  D SD
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSD 834


>AF094508-1|AAD16120.1|  788|Homo sapiens dentin phosphoryn protein.
          Length = 788

 Score = 33.5 bits (73), Expect = 6.5
 Identities = 51/272 (18%), Positives = 101/272 (37%), Gaps = 6/272 (2%)

Query: 358 NSEDMELIDMLHDMDQQRVEEDSIMGTPANR-DQEVDMELDDAEYSRIFNDDSVCHD-QN 415
           +S D +  D     D    + DS   + ++  D     +  D+  S   +D S   D ++
Sbjct: 103 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 162

Query: 416 ESENNGSPLSWHDSFWDGANIPQLDGTFDNDHXXXXXXXXXX-XLQLGLSRPKKKNERVN 474
           +S  + S  S  DS  D ++    D + ++D                  S     +   +
Sbjct: 163 DSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSS 222

Query: 475 NPTNTDSNIDTSEIDEINVSRETADGDVCISELVRASKISKTSIENTEIKSEETFIDAVS 534
           N +++  + D+S   E + S +++D D   S     S  S +   N+   S+ +     S
Sbjct: 223 NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 282

Query: 535 RITAKQNIVKLMNKSEIYDLQNKFVPTAGPSNKPVDCDNTEMGNSSNNELELSPDGNELG 594
             +   N     + S+  +  +     +  S+   D  N+   N S+N  + S   +   
Sbjct: 283 DSSDSSNSSDSSDSSDSSNSSDS--SDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSDSSD 340

Query: 595 IVSFYDASKVFDDS-FNQTFLQEQTNCDDCSD 625
             +  D+S   D S  + +   + +N  D SD
Sbjct: 341 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSD 372


>AL353596-4|CAI17914.1|  632|Homo sapiens HBS1-like (S. cerevisiae)
           protein.
          Length = 632

 Score = 33.1 bits (72), Expect = 8.6
 Identities = 45/223 (20%), Positives = 90/223 (40%), Gaps = 10/223 (4%)

Query: 474 NNPTNTDSNIDTSEIDEINVSRETADGDVCISELVRASKISKTSIENTEI-KSEETFIDA 532
           NNP    S+++   +D +N S+ET  G+V + E  +++K      +N +  + E   +  
Sbjct: 321 NNPLYLTSSLENMTVDNLNASKETEVGNVSLVE--QSAKNHTFKNDNLQFSQCESPSLTE 378

Query: 533 VSRITAKQNIVKLMNKSEIYDLQNKFVPTAGPSNKPVDCDNTEMGNSSNNELELSPDGNE 592
           + +   + NI +    S++ +  +         + P+    +++ N   +   +S     
Sbjct: 379 LFQEHKENNISQCFTLSDLCNQSSASFTDLSLGSFPL----SQLANRCQSSPGISELTGS 434

Query: 593 LGIVSFYDASKVFD-DSFNQTFLQEQTNCDDCSDIIANEYEKQEDYDKFKDTELKLDVSV 651
           L  ++F+ AS   D ++ + + L  +T   D S I    +E      +    +  +D+SV
Sbjct: 435 LSSLAFHKASPTRDLENLSLSELIAETIDVDNSQIKKESFEVSLSEVRSPGIDSNIDLSV 494

Query: 652 NEKLDTGIKIFTPTVKPPTKNEMETKYKIPKTKQVQPFFSDYK 694
             K    +    P V P       TK    K  +   F  D K
Sbjct: 495 LIKNPDFVP--KPVVDPSIAPSSRTKVLSSKLGKNSNFAKDNK 535


>AJ459827-1|CAD30874.1|  632|Homo sapiens HBS1-like protein protein.
          Length = 632

 Score = 33.1 bits (72), Expect = 8.6
 Identities = 45/223 (20%), Positives = 90/223 (40%), Gaps = 10/223 (4%)

Query: 474 NNPTNTDSNIDTSEIDEINVSRETADGDVCISELVRASKISKTSIENTEI-KSEETFIDA 532
           NNP    S+++   +D +N S+ET  G+V + E  +++K      +N +  + E   +  
Sbjct: 321 NNPLYLTSSLENMTVDNLNASKETEVGNVSLVE--QSAKNHTFKNDNLQFSQCESPSLTE 378

Query: 533 VSRITAKQNIVKLMNKSEIYDLQNKFVPTAGPSNKPVDCDNTEMGNSSNNELELSPDGNE 592
           + +   + NI +    S++ +  +         + P+    +++ N   +   +S     
Sbjct: 379 LFQEHKENNISQCFTLSDLCNQSSASFTDLSLGSFPL----SQLANRCQSSPGISELTGS 434

Query: 593 LGIVSFYDASKVFD-DSFNQTFLQEQTNCDDCSDIIANEYEKQEDYDKFKDTELKLDVSV 651
           L  ++F+ AS   D ++ + + L  +T   D S I    +E      +    +  +D+SV
Sbjct: 435 LSSLAFHKASPTRDLENLSLSELIAETIDVDNSQIKKESFEVSLSEVRSPGIDSNIDLSV 494

Query: 652 NEKLDTGIKIFTPTVKPPTKNEMETKYKIPKTKQVQPFFSDYK 694
             K    +    P V P       TK    K  +   F  D K
Sbjct: 495 LIKNPDFVP--KPVVDPSIAPSSRTKVLSSKLGKNSNFAKDNK 535


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.317    0.133    0.392 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 229,064,042
Number of Sequences: 224733
Number of extensions: 9464468
Number of successful extensions: 21557
Number of sequences better than 10.0: 36
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 21331
Number of HSP's gapped (non-prelim): 136
length of query: 1644
length of database: 73,234,838
effective HSP length: 100
effective length of query: 1544
effective length of database: 50,761,538
effective search space: 78375814672
effective search space used: 78375814672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 72 (33.1 bits)