BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002392-TA|BGIBMGA002392-PA|undefined
(199 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Y08136-1|CAA69330.1| 177|Homo sapiens acid sphingomyelinase-lik... 62 1e-09
BC018999-1|AAH18999.1| 453|Homo sapiens sphingomyelin phosphodi... 62 1e-09
AL732431-1|CAI23631.1| 453|Homo sapiens XXyac-YR36GH4.1 protein. 62 1e-09
AL512288-3|CAI14293.1| 455|Homo sapiens sphingomyelin phosphodi... 60 5e-09
Y08134-1|CAA69328.1| 465|Homo sapiens acid sphingomyelinase-lik... 56 6e-08
BC014444-1|AAH14444.1| 373|Homo sapiens sphingomyelin phosphodi... 44 4e-04
AL512288-5|CAI14295.1| 269|Homo sapiens sphingomyelin phosphodi... 44 4e-04
AL512288-4|CAI14294.1| 373|Homo sapiens sphingomyelin phosphodi... 44 4e-04
X63600-1|CAA45145.1| 629|Homo sapiens acid sphingomyelinase pro... 40 0.006
X59960-1|CAA42584.1| 627|Homo sapiens sphingomyelin phosphodies... 40 0.006
X52678-1|CAA36901.1| 502|Homo sapiens acid sphingomyelinase (50... 40 0.006
M81780-2|AAA75009.1| 597|Homo sapiens acid sphingomyelinase pro... 40 0.006
M81780-1|AAA75008.1| 629|Homo sapiens acid sphingomyelinase pro... 40 0.006
M59917-2|AAA58378.1| 127|Homo sapiens acid sphingomyelinase pro... 40 0.006
M59916-1|AAA58377.1| 629|Homo sapiens acid sphingomyelinase pro... 40 0.006
AB209775-1|BAD93012.1| 664|Homo sapiens sphingomyelin phosphodi... 40 0.006
X52679-1|CAA36902.1| 316|Homo sapiens acid sphingomyelinase (31... 37 0.041
>Y08136-1|CAA69330.1| 177|Homo sapiens acid sphingomyelinase-like
phosphodiesterase protein.
Length = 177
Score = 62.5 bits (145), Expect = 1e-09
Identities = 34/101 (33%), Positives = 53/101 (52%), Gaps = 4/101 (3%)
Query: 73 VLDYTQYYLDVT--NPKGEIHWSIEYNLTQYYGLREINAASLHALAEKIRSHHDRSVFNK 130
+LD QYYL++T N KGE W +EY LTQ Y + ++ SL+ LA++ + D F K
Sbjct: 71 LLDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQF-TILDSKQFIK 129
Query: 131 YLTALRVRHSTDTSDCDASCAHVHYCAVTRADYSEFRSCVR 171
Y V + + + CD +C CA+ D + C++
Sbjct: 130 YYNYFFVSYDSSVT-CDKTCKAFQICAIMNLDNISYADCLK 169
>BC018999-1|AAH18999.1| 453|Homo sapiens sphingomyelin
phosphodiesterase, acid-like 3A protein.
Length = 453
Score = 62.5 bits (145), Expect = 1e-09
Identities = 34/101 (33%), Positives = 53/101 (52%), Gaps = 4/101 (3%)
Query: 73 VLDYTQYYLDVT--NPKGEIHWSIEYNLTQYYGLREINAASLHALAEKIRSHHDRSVFNK 130
+LD QYYL++T N KGE W +EY LTQ Y + ++ SL+ LA++ + D F K
Sbjct: 347 LLDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQF-TILDSKQFIK 405
Query: 131 YLTALRVRHSTDTSDCDASCAHVHYCAVTRADYSEFRSCVR 171
Y V + + + CD +C CA+ D + C++
Sbjct: 406 YYNYFFVSYDSSVT-CDKTCKAFQICAIMNLDNISYADCLK 445
Score = 48.8 bits (111), Expect = 1e-05
Identities = 25/74 (33%), Positives = 40/74 (54%), Gaps = 1/74 (1%)
Query: 1 MWRQWLPTEALQTFEIGGYYTIE-QSHSKLRIIVLNSVLWAGGAARTDGPNVGRAQWEWL 59
+W+ WL EA+ T GG+Y+ + ++ LRII LN+ L+ G T Q+EWL
Sbjct: 174 LWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWL 233
Query: 60 NQVLSTARKKSEMV 73
L+ +++ E V
Sbjct: 234 ESTLNNSQQNKEKV 247
>AL732431-1|CAI23631.1| 453|Homo sapiens XXyac-YR36GH4.1 protein.
Length = 453
Score = 62.5 bits (145), Expect = 1e-09
Identities = 34/101 (33%), Positives = 53/101 (52%), Gaps = 4/101 (3%)
Query: 73 VLDYTQYYLDVT--NPKGEIHWSIEYNLTQYYGLREINAASLHALAEKIRSHHDRSVFNK 130
+LD QYYL++T N KGE W +EY LTQ Y + ++ SL+ LA++ + D F K
Sbjct: 347 LLDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQF-TILDSKQFIK 405
Query: 131 YLTALRVRHSTDTSDCDASCAHVHYCAVTRADYSEFRSCVR 171
Y V + + + CD +C CA+ D + C++
Sbjct: 406 YYNYFFVSYDSSVT-CDKTCKAFQICAIMNLDNISYADCLK 445
Score = 48.8 bits (111), Expect = 1e-05
Identities = 25/74 (33%), Positives = 40/74 (54%), Gaps = 1/74 (1%)
Query: 1 MWRQWLPTEALQTFEIGGYYTIE-QSHSKLRIIVLNSVLWAGGAARTDGPNVGRAQWEWL 59
+W+ WL EA+ T GG+Y+ + ++ LRII LN+ L+ G T Q+EWL
Sbjct: 174 LWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWL 233
Query: 60 NQVLSTARKKSEMV 73
L+ +++ E V
Sbjct: 234 ESTLNNSQQNKEKV 247
>AL512288-3|CAI14293.1| 455|Homo sapiens sphingomyelin
phosphodiesterase, acid-like 3B protein.
Length = 455
Score = 60.1 bits (139), Expect = 5e-09
Identities = 28/98 (28%), Positives = 53/98 (54%), Gaps = 6/98 (6%)
Query: 75 DYTQYYLDVT--NPKGEIHWSIEYNLTQYYGLREINAASLHALAEKIRSHHDRSVFNKYL 132
D Y+++++ N +G W +EY LT+ YG+ + +A S+H + ++I D+S +Y
Sbjct: 336 DMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDRIAG--DQSTLQRYY 393
Query: 133 TALRVRHSTDTSDCDASCAHVHYCAVTRADYSEFRSCV 170
V +S CD +C+ H CA+ + D + +C+
Sbjct: 394 VYNSVSYSAGV--CDEACSMQHVCAMRQVDIDAYTTCL 429
Score = 44.0 bits (99), Expect = 4e-04
Identities = 25/76 (32%), Positives = 41/76 (53%), Gaps = 4/76 (5%)
Query: 1 MWRQWLPTEALQTFEIGGYYT--IEQSHSKLRIIVLNSVLW-AGGAARTDGPNVGRAQWE 57
+W+ WL E++ F+ G +Y + RI+VLN+ L+ A D + G+ Q++
Sbjct: 157 LWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQ-QFQ 215
Query: 58 WLNQVLSTARKKSEMV 73
WL VL+ A K +MV
Sbjct: 216 WLEDVLTDASKAGDMV 231
>Y08134-1|CAA69328.1| 465|Homo sapiens acid sphingomyelinase-like
phosphodiesterase protein.
Length = 465
Score = 56.4 bits (130), Expect = 6e-08
Identities = 27/98 (27%), Positives = 52/98 (53%), Gaps = 6/98 (6%)
Query: 75 DYTQYYLDVT--NPKGEIHWSIEYNLTQYYGLREINAASLHALAEKIRSHHDRSVFNKYL 132
D Y+++++ N +G W +EY LT+ YG+ + +A S+ + ++I D+S +Y
Sbjct: 336 DMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSIDTVLDRIAG--DQSTLQRYY 393
Query: 133 TALRVRHSTDTSDCDASCAHVHYCAVTRADYSEFRSCV 170
V +S CD +C+ H CA+ + D + +C+
Sbjct: 394 VYNSVSYSAGV--CDEACSMQHVCAMRQVDIDAYTTCL 429
Score = 44.0 bits (99), Expect = 4e-04
Identities = 25/76 (32%), Positives = 41/76 (53%), Gaps = 4/76 (5%)
Query: 1 MWRQWLPTEALQTFEIGGYYT--IEQSHSKLRIIVLNSVLW-AGGAARTDGPNVGRAQWE 57
+W+ WL E++ F+ G +Y + RI+VLN+ L+ A D + G+ Q++
Sbjct: 157 LWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQ-QFQ 215
Query: 58 WLNQVLSTARKKSEMV 73
WL VL+ A K +MV
Sbjct: 216 WLEDVLTDASKAGDMV 231
>BC014444-1|AAH14444.1| 373|Homo sapiens sphingomyelin
phosphodiesterase, acid-like 3B protein.
Length = 373
Score = 44.0 bits (99), Expect = 4e-04
Identities = 25/76 (32%), Positives = 41/76 (53%), Gaps = 4/76 (5%)
Query: 1 MWRQWLPTEALQTFEIGGYYT--IEQSHSKLRIIVLNSVLW-AGGAARTDGPNVGRAQWE 57
+W+ WL E++ F+ G +Y + RI+VLN+ L+ A D + G+ Q++
Sbjct: 157 LWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQ-QFQ 215
Query: 58 WLNQVLSTARKKSEMV 73
WL VL+ A K +MV
Sbjct: 216 WLEDVLTDASKAGDMV 231
>AL512288-5|CAI14295.1| 269|Homo sapiens sphingomyelin
phosphodiesterase, acid-like 3B protein.
Length = 269
Score = 44.0 bits (99), Expect = 4e-04
Identities = 25/76 (32%), Positives = 41/76 (53%), Gaps = 4/76 (5%)
Query: 1 MWRQWLPTEALQTFEIGGYYT--IEQSHSKLRIIVLNSVLW-AGGAARTDGPNVGRAQWE 57
+W+ WL E++ F+ G +Y + RI+VLN+ L+ A D + G+ Q++
Sbjct: 187 LWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQ-QFQ 245
Query: 58 WLNQVLSTARKKSEMV 73
WL VL+ A K +MV
Sbjct: 246 WLEDVLTDASKAGDMV 261
>AL512288-4|CAI14294.1| 373|Homo sapiens sphingomyelin
phosphodiesterase, acid-like 3B protein.
Length = 373
Score = 44.0 bits (99), Expect = 4e-04
Identities = 25/76 (32%), Positives = 41/76 (53%), Gaps = 4/76 (5%)
Query: 1 MWRQWLPTEALQTFEIGGYYT--IEQSHSKLRIIVLNSVLW-AGGAARTDGPNVGRAQWE 57
+W+ WL E++ F+ G +Y + RI+VLN+ L+ A D + G+ Q++
Sbjct: 157 LWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQ-QFQ 215
Query: 58 WLNQVLSTARKKSEMV 73
WL VL+ A K +MV
Sbjct: 216 WLEDVLTDASKAGDMV 231
>X63600-1|CAA45145.1| 629|Homo sapiens acid sphingomyelinase
protein.
Length = 629
Score = 39.9 bits (89), Expect = 0.006
Identities = 17/34 (50%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 2 WRQWLPTEALQTFEIGGYYTIEQSHSKLRIIVLN 35
W WLP EAL+T IGG+Y + + LR+I LN
Sbjct: 349 WEPWLPAEALRTLRIGGFYAL-SPYPGLRLISLN 381
Score = 37.1 bits (82), Expect = 0.041
Identities = 27/100 (27%), Positives = 41/100 (41%), Gaps = 6/100 (6%)
Query: 61 QVLSTARKKSEMVLDYTQYYLDVT--NPKGEI-HWSIEYNLTQYYGLREINAASLHALAE 117
Q+ + S +VLD+ Y L++T N G I HW + Y + YGL + H L
Sbjct: 499 QIDGNYSRSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVY 558
Query: 118 KIRSHHDRSVFNKYLTALRVRHSTDTSDCDASCAHVHYCA 157
++R D +F + H + C C CA
Sbjct: 559 RMRG--DMQLFQTFWFLYHKGH-PPSEPCGTPCRLATLCA 595
>X59960-1|CAA42584.1| 627|Homo sapiens sphingomyelin
phosphodiesterase protein.
Length = 627
Score = 39.9 bits (89), Expect = 0.006
Identities = 17/34 (50%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 2 WRQWLPTEALQTFEIGGYYTIEQSHSKLRIIVLN 35
W WLP EAL+T IGG+Y + + LR+I LN
Sbjct: 347 WEPWLPAEALRTLRIGGFYAL-SPYPGLRLISLN 379
Score = 35.9 bits (79), Expect = 0.095
Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 6/91 (6%)
Query: 70 SEMVLDYTQYYLDVT--NPKGEI-HWSIEYNLTQYYGLREINAASLHALAEKIRSHHDRS 126
S +VLD+ Y L++T N G I HW + Y + YGL + H L ++R D
Sbjct: 506 SHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG--DMQ 563
Query: 127 VFNKYLTALRVRHSTDTSDCDASCAHVHYCA 157
+F + H + C C CA
Sbjct: 564 LFQTFWFLYHKGH-PPSEPCGTPCRLATLCA 593
>X52678-1|CAA36901.1| 502|Homo sapiens acid sphingomyelinase (502
AA) protein.
Length = 502
Score = 39.9 bits (89), Expect = 0.006
Identities = 17/34 (50%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 2 WRQWLPTEALQTFEIGGYYTIEQSHSKLRIIVLN 35
W WLP EAL+T IGG+Y + + LR+I LN
Sbjct: 222 WEPWLPAEALRTLRIGGFYAL-SPYPGLRLISLN 254
Score = 37.1 bits (82), Expect = 0.041
Identities = 27/100 (27%), Positives = 41/100 (41%), Gaps = 6/100 (6%)
Query: 61 QVLSTARKKSEMVLDYTQYYLDVT--NPKGEI-HWSIEYNLTQYYGLREINAASLHALAE 117
Q+ + S +VLD+ Y L++T N G I HW + Y + YGL + H L
Sbjct: 372 QIDGNYSRSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVY 431
Query: 118 KIRSHHDRSVFNKYLTALRVRHSTDTSDCDASCAHVHYCA 157
++R D +F + H + C C CA
Sbjct: 432 RMRG--DMQLFQTFWFLYHKGH-PPSEPCGTPCRLATLCA 468
>M81780-2|AAA75009.1| 597|Homo sapiens acid sphingomyelinase
protein.
Length = 597
Score = 39.9 bits (89), Expect = 0.006
Identities = 17/34 (50%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 2 WRQWLPTEALQTFEIGGYYTIEQSHSKLRIIVLN 35
W WLP EAL+T IGG+Y + + LR+I LN
Sbjct: 317 WEPWLPAEALRTLRIGGFYAL-SPYPGLRLISLN 349
Score = 35.9 bits (79), Expect = 0.095
Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 6/91 (6%)
Query: 70 SEMVLDYTQYYLDVT--NPKGEI-HWSIEYNLTQYYGLREINAASLHALAEKIRSHHDRS 126
S +VLD+ Y L++T N G I HW + Y + YGL + H L ++R D
Sbjct: 476 SHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG--DMQ 533
Query: 127 VFNKYLTALRVRHSTDTSDCDASCAHVHYCA 157
+F + H + C C CA
Sbjct: 534 LFQTFWFLYHKGH-PPSEPCGTPCRLATLCA 563
>M81780-1|AAA75008.1| 629|Homo sapiens acid sphingomyelinase
protein.
Length = 629
Score = 39.9 bits (89), Expect = 0.006
Identities = 17/34 (50%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 2 WRQWLPTEALQTFEIGGYYTIEQSHSKLRIIVLN 35
W WLP EAL+T IGG+Y + + LR+I LN
Sbjct: 349 WEPWLPAEALRTLRIGGFYAL-SPYPGLRLISLN 381
Score = 35.9 bits (79), Expect = 0.095
Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 6/91 (6%)
Query: 70 SEMVLDYTQYYLDVT--NPKGEI-HWSIEYNLTQYYGLREINAASLHALAEKIRSHHDRS 126
S +VLD+ Y L++T N G I HW + Y + YGL + H L ++R D
Sbjct: 508 SHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG--DMQ 565
Query: 127 VFNKYLTALRVRHSTDTSDCDASCAHVHYCA 157
+F + H + C C CA
Sbjct: 566 LFQTFWFLYHKGH-PPSEPCGTPCRLATLCA 595
>M59917-2|AAA58378.1| 127|Homo sapiens acid sphingomyelinase
protein.
Length = 127
Score = 39.9 bits (89), Expect = 0.006
Identities = 17/34 (50%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 2 WRQWLPTEALQTFEIGGYYTIEQSHSKLRIIVLN 35
W WLP EAL+T IGG+Y + + LR+I LN
Sbjct: 33 WEPWLPAEALRTLRIGGFYAL-SPYPGLRLISLN 65
>M59916-1|AAA58377.1| 629|Homo sapiens acid sphingomyelinase
protein.
Length = 629
Score = 39.9 bits (89), Expect = 0.006
Identities = 17/34 (50%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 2 WRQWLPTEALQTFEIGGYYTIEQSHSKLRIIVLN 35
W WLP EAL+T IGG+Y + + LR+I LN
Sbjct: 349 WEPWLPAEALRTLRIGGFYAL-SPYPGLRLISLN 381
Score = 37.1 bits (82), Expect = 0.041
Identities = 27/100 (27%), Positives = 41/100 (41%), Gaps = 6/100 (6%)
Query: 61 QVLSTARKKSEMVLDYTQYYLDVT--NPKGEI-HWSIEYNLTQYYGLREINAASLHALAE 117
Q+ + S +VLD+ Y L++T N G I HW + Y + YGL + H L
Sbjct: 499 QIDGNYSRSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVY 558
Query: 118 KIRSHHDRSVFNKYLTALRVRHSTDTSDCDASCAHVHYCA 157
++R D +F + H + C C CA
Sbjct: 559 RMRG--DMQLFQTFWFLYHKGH-PPSEPCGTPCRLATLCA 595
>AB209775-1|BAD93012.1| 664|Homo sapiens sphingomyelin
phosphodiesterase 1, acid lysosomal isoform 1 precursor
variant protein.
Length = 664
Score = 39.9 bits (89), Expect = 0.006
Identities = 17/34 (50%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 2 WRQWLPTEALQTFEIGGYYTIEQSHSKLRIIVLN 35
W WLP EAL+T IGG+Y + + LR+I LN
Sbjct: 384 WEPWLPAEALRTLRIGGFYAL-SPYPGLRLISLN 416
Score = 35.9 bits (79), Expect = 0.095
Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 6/91 (6%)
Query: 70 SEMVLDYTQYYLDVT--NPKGEI-HWSIEYNLTQYYGLREINAASLHALAEKIRSHHDRS 126
S +VLD+ Y L++T N G I HW + Y + YGL + H L ++R D
Sbjct: 543 SHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG--DMQ 600
Query: 127 VFNKYLTALRVRHSTDTSDCDASCAHVHYCA 157
+F + H + C C CA
Sbjct: 601 LFQTFWFLYHKGH-PPSEPCGTPCRLATLCA 630
>X52679-1|CAA36902.1| 316|Homo sapiens acid sphingomyelinase (317
AA) protein.
Length = 316
Score = 37.1 bits (82), Expect = 0.041
Identities = 27/100 (27%), Positives = 41/100 (41%), Gaps = 6/100 (6%)
Query: 61 QVLSTARKKSEMVLDYTQYYLDVT--NPKGEI-HWSIEYNLTQYYGLREINAASLHALAE 117
Q+ + S +VLD+ Y L++T N G I HW + Y + YGL + H L
Sbjct: 186 QIDGNYSRSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVY 245
Query: 118 KIRSHHDRSVFNKYLTALRVRHSTDTSDCDASCAHVHYCA 157
++R D +F + H + C C CA
Sbjct: 246 RMRG--DMQLFQTFWFLYHKGH-PPSEPCGTPCRLATLCA 282
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.130 0.403
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 29,447,034
Number of Sequences: 224733
Number of extensions: 1107398
Number of successful extensions: 1813
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 1774
Number of HSP's gapped (non-prelim): 29
length of query: 199
length of database: 73,234,838
effective HSP length: 86
effective length of query: 113
effective length of database: 53,907,800
effective search space: 6091581400
effective search space used: 6091581400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 63 (29.5 bits)
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