Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002361-TA|BGIBMGA002361-PA|IPR001680|WD-40 repeat,
IPR011046|WD40-like, IPR011044|Quinoprotein amine dehydrogenase, beta
chain-like
(482 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC010080-1|AAH10080.1| 305|Homo sapiens WD repeat domain 61 pro... 297 7e-80
AK024754-1|BAB14986.1| 305|Homo sapiens protein ( Homo sapiens ... 297 7e-80
AF309553-1|AAG31639.1| 305|Homo sapiens meiotic recombination p... 297 7e-80
AF100786-1|AAP97225.1| 305|Homo sapiens G protein beta subunit-... 297 7e-80
CR457333-1|CAG33614.1| 305|Homo sapiens REC14 protein. 295 3e-79
AF127799-1|AAP97249.1| 305|Homo sapiens G protein beta subunit-... 288 3e-77
BC012075-1|AAH12075.1| 485|Homo sapiens notchless homolog 1 (Dr... 138 3e-32
BC002884-1|AAH02884.2| 484|Homo sapiens NLE1 protein protein. 138 3e-32
AK001320-1|BAA91621.1| 485|Homo sapiens protein ( Homo sapiens ... 138 3e-32
AB209111-1|BAD92348.1| 487|Homo sapiens Notchless gene homolog ... 137 7e-32
BC036377-1|AAH36377.1| 415|Homo sapiens WD repeat domain 69 pro... 134 5e-31
AK097409-1|BAC05039.1| 415|Homo sapiens protein ( Homo sapiens ... 134 5e-31
AC073065-2|AAX93215.1| 415|Homo sapiens unknown protein. 134 5e-31
AK098821-1|BAC05425.1| 415|Homo sapiens protein ( Homo sapiens ... 134 7e-31
BX649632-1|CAI18774.1| 334|Homo sapiens WD repeat domain 5 prot... 126 2e-28
BC001635-1|AAH01635.1| 334|Homo sapiens WD repeat domain 5 prot... 126 2e-28
AK000552-1|BAA91248.1| 334|Homo sapiens protein ( Homo sapiens ... 126 2e-28
AJ011376-1|CAB66159.1| 362|Homo sapiens hypothetical protein pr... 126 2e-28
AK002149-1|BAA92110.1| 330|Homo sapiens protein ( Homo sapiens ... 122 3e-27
CR457279-1|CAG33560.1| 330|Homo sapiens WDR5B protein. 122 4e-27
BC043494-1|AAH43494.1| 330|Homo sapiens WD repeat domain 5B pro... 122 4e-27
BC127949-1|AAI27950.1| 314|Homo sapiens similar to hypothetical... 115 3e-25
AL354928-6|CAI39637.1| 314|Homo sapiens WD repeat domain 38 pro... 115 4e-25
AJ243107-1|CAB56462.1| 1171|Homo sapiens apoptotic protease acti... 113 1e-24
AJ243005-1|CAB55581.1| 1205|Homo sapiens apoptotic protease acti... 113 1e-24
AJ243004-1|CAB55580.1| 1205|Homo sapiens apoptotic protease acti... 113 1e-24
AJ243003-1|CAB55579.1| 1205|Homo sapiens apoptotic protease acti... 113 1e-24
AF013263-1|AAC51678.1| 1194|Homo sapiens apoptotic protease acti... 113 1e-24
EF011619-1|ABK41109.1| 478|Homo sapiens CDW9/WDR51B protein. 113 1e-24
BC026080-1|AAH26080.1| 478|Homo sapiens WD repeat domain 51B pr... 113 1e-24
AK074772-1|BAC11198.1| 478|Homo sapiens protein ( Homo sapiens ... 113 1e-24
AJ243006-1|CAB55582.1| 1205|Homo sapiens apoptotic protease acti... 113 1e-24
AJ243007-1|CAB55583.1| 1205|Homo sapiens apoptotic protease acti... 113 2e-24
AJ243011-1|CAB55587.1| 1205|Homo sapiens protease activating fac... 112 3e-24
AJ243010-1|CAB55586.1| 1205|Homo sapiens apoptotic protease acti... 112 3e-24
AJ243008-1|CAB55584.1| 1205|Homo sapiens apoptotic protease acti... 110 9e-24
U82756-1|AAC02261.1| 520|Homo sapiens WD splicing factor Hprp4p... 109 3e-23
CR457105-1|CAG33386.1| 521|Homo sapiens PRPF4 protein. 109 3e-23
BC007424-1|AAH07424.1| 521|Homo sapiens PRP4 pre-mRNA processin... 109 3e-23
BC001588-1|AAH01588.1| 522|Homo sapiens PRP4 pre-mRNA processin... 109 3e-23
AY572489-1|AAS78572.1| 521|Homo sapiens 60 kDa U4/U6 snRNP-spec... 109 3e-23
AL449305-8|CAI10969.1| 521|Homo sapiens PRP4 pre-mRNA processin... 109 3e-23
AL449305-7|CAI10968.1| 522|Homo sapiens PRP4 pre-mRNA processin... 109 3e-23
AF016369-1|AAC51925.1| 522|Homo sapiens U4/U6 small nuclear rib... 109 3e-23
AB209797-1|BAD93034.1| 537|Homo sapiens PRPF4 protein variant p... 109 3e-23
AK127882-1|BAC87175.1| 369|Homo sapiens protein ( Homo sapiens ... 108 4e-23
X95525-1|CAA64777.1| 799|Homo sapiens hTAFII100 protein. 107 6e-23
U80191-1|AAC51215.1| 800|Homo sapiens TFIID subunit TAFII100 pr... 107 6e-23
U75309-1|AAC50902.1| 801|Homo sapiens TBP-associated factor pro... 107 6e-23
BC052268-1|AAH52268.2| 800|Homo sapiens TAF5 RNA polymerase II,... 107 6e-23
AL591408-4|CAI16747.1| 800|Homo sapiens TAF5 RNA polymerase II,... 107 6e-23
AK223615-1|BAD97335.1| 803|Homo sapiens Transcription initiatio... 107 6e-23
AF001687-1|AAB87640.1| 521|Homo sapiens U4/U6 snRNP 60 kDa prot... 106 2e-22
EF079890-1|ABN48555.1| 444|Homo sapiens ATG16 autophagy related... 103 1e-21
EF079889-1|ABN48554.1| 588|Homo sapiens ATG16 autophagy related... 103 1e-21
BC117337-1|AAI17338.1| 523|Homo sapiens ATG16L1 protein protein. 103 1e-21
BC071846-1|AAH71846.1| 475|Homo sapiens ATG16L1 protein protein. 103 1e-21
AY398617-1|AAR32130.1| 607|Homo sapiens APG16L beta protein. 103 1e-21
AC013726-3|AAY14860.1| 523|Homo sapiens unknown protein. 103 1e-21
X04526-2|CAA28207.1| 340|Homo sapiens protein ( Human liver mRN... 103 1e-21
CR456784-1|CAG33065.1| 340|Homo sapiens GNB1 protein. 103 1e-21
BT007305-1|AAP35969.1| 340|Homo sapiens guanine nucleotide bind... 103 1e-21
BC114618-1|AAI14619.1| 332|Homo sapiens GNB1 protein protein. 103 1e-21
BC008991-1|AAH08991.1| 340|Homo sapiens guanine nucleotide bind... 103 1e-21
BC005888-1|AAH05888.1| 340|Homo sapiens guanine nucleotide bind... 103 1e-21
BC004186-1|AAH04186.1| 340|Homo sapiens guanine nucleotide bind... 103 1e-21
AL109917-5|CAI95654.1| 340|Homo sapiens guanine nucleotide bind... 103 1e-21
AL031282-2|CAI20029.1| 340|Homo sapiens guanine nucleotide bind... 103 1e-21
AF501882-1|AAM15918.1| 340|Homo sapiens guanine nucleotide bind... 103 1e-21
AK027854-1|BAB55412.1| 504|Homo sapiens protein ( Homo sapiens ... 102 2e-21
M24194-1|AAA59626.1| 317|Homo sapiens MHC B complex protein 12.... 102 3e-21
CR541909-1|CAG46707.1| 317|Homo sapiens GNB2L1 protein. 102 3e-21
CR456978-1|CAG33259.1| 317|Homo sapiens GNB2L1 protein. 102 3e-21
CR456762-1|CAG33043.1| 655|Homo sapiens KATNB1 protein. 102 3e-21
BT007022-1|AAP35668.1| 655|Homo sapiens katanin p80 (WD40-conta... 102 3e-21
BC032006-1|AAH32006.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
BC021993-1|AAH21993.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
BC019362-1|AAH19362.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
BC019093-1|AAH19093.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
BC017287-1|AAH17287.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
BC014788-1|AAH14788.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
BC014256-1|AAH14256.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
BC010119-1|AAH10119.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
BC001353-1|AAH01353.1| 655|Homo sapiens katanin p80 (WD repeat ... 102 3e-21
BC000873-1|AAH00873.1| 340|Homo sapiens guanine nucleotide bind... 102 3e-21
BC000366-1|AAH00366.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
BC000214-1|AAH00214.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
AY159316-1|AAO21313.1| 347|Homo sapiens lung cancer oncogene 7 ... 102 3e-21
AK222488-1|BAD96208.1| 317|Homo sapiens guanine nucleotide bind... 102 3e-21
AF300648-1|AAG18442.1| 340|Homo sapiens guanine nucleotide bind... 102 3e-21
M36429-1|AAA63264.1| 340|Homo sapiens protein ( Human transduci... 101 4e-21
M16514-1|AAA03179.1| 340|Homo sapiens GNB2 protein. 101 4e-21
CR541729-1|CAG46530.1| 340|Homo sapiens GNB2 protein. 101 4e-21
BC068003-1|AAH68003.1| 340|Homo sapiens guanine nucleotide bind... 101 4e-21
BC012348-1|AAH12348.1| 340|Homo sapiens guanine nucleotide bind... 101 4e-21
BC010073-1|AAH10073.1| 340|Homo sapiens guanine nucleotide bind... 101 4e-21
AF501883-1|AAM15919.1| 340|Homo sapiens guanine nucleotide bind... 101 4e-21
AF053356-4|AAC78794.1| 340|Homo sapiens GNB2 protein. 101 4e-21
BC119693-1|AAI19694.1| 441|Homo sapiens WDR51A protein protein. 99 2e-20
BC119692-1|AAI19693.1| 407|Homo sapiens WD repeat domain 51A pr... 99 2e-20
BC110877-1|AAI10878.1| 359|Homo sapiens WDR51A protein protein. 99 2e-20
BC007417-1|AAH07417.2| 396|Homo sapiens WDR51A protein protein. 99 2e-20
BC130473-1|AAI30474.1| 522|Homo sapiens transducin (beta)-like ... 100 2e-20
BC130471-1|AAI30472.1| 522|Homo sapiens transducin (beta)-like ... 100 2e-20
AK075289-1|BAC11525.1| 407|Homo sapiens protein ( Homo sapiens ... 100 2e-20
AF332222-1|AAK13474.1| 522|Homo sapiens transducin beta-like 1 ... 100 2e-20
AF332221-1|AAK13473.1| 522|Homo sapiens transducin beta-like 1 ... 100 2e-20
AF332220-1|AAK13472.1| 522|Homo sapiens transducin beta-like 1 ... 100 2e-20
AK001667-1|BAA91822.1| 513|Homo sapiens protein ( Homo sapiens ... 99 4e-20
AJ243048-1|CAB55588.1| 1248|Homo sapiens apoptotic protease acti... 99 4e-20
AJ243009-1|CAB55585.1| 1248|Homo sapiens apoptotic protease acti... 99 4e-20
AF149794-1|AAD34016.1| 1248|Homo sapiens apoptotic protease acti... 99 4e-20
AF134397-1|AAD38344.1| 1237|Homo sapiens apoptotic protease acti... 99 4e-20
AF052432-1|AAC09328.1| 655|Homo sapiens katanin p80 subunit pro... 99 4e-20
AB007873-1|BAA24843.2| 1237|Homo sapiens KIAA0413 protein. 99 4e-20
U72342-1|AAC51111.1| 410|Homo sapiens platelet activating facto... 98 5e-20
L13386-1|AAA02881.1| 410|Homo sapiens Miller-Dieker lissencepha... 98 5e-20
L13385-1|AAA02880.1| 410|Homo sapiens Miller-Dieker lissencepha... 98 5e-20
EF011613-1|ABK41103.1| 513|Homo sapiens CDW3/SMU1 protein. 98 5e-20
BC064638-1|AAH64638.1| 410|Homo sapiens platelet-activating fac... 98 5e-20
BC002876-1|AAH02876.1| 513|Homo sapiens smu-1 suppressor of mec... 98 5e-20
AL162590-6|CAI15554.1| 513|Homo sapiens smu-1 suppressor of mec... 98 5e-20
AL121990-7|CAI22015.1| 589|Homo sapiens TAF5-like RNA polymeras... 98 5e-20
AJ009770-1|CAA08816.1| 260|Homo sapiens putative transcription ... 98 5e-20
AF400434-1|AAK92483.1| 410|Homo sapiens platelet-activating fac... 98 5e-20
AF208837-1|AAL34972.1| 410|Homo sapiens Miller-Dieker lissencep... 98 5e-20
AF069736-1|AAC39906.1| 589|Homo sapiens PCAF associated factor ... 98 5e-20
BC015920-1|AAH15920.1| 297|Homo sapiens GNB3 protein protein. 97 9e-20
BC110654-1|AAI10655.1| 513|Homo sapiens smu-1 suppressor of mec... 97 1e-19
AF208838-1|AAL34973.1| 410|Homo sapiens Miller-Dieker lissencep... 97 2e-19
M16538-1|AAA35922.1| 340|Homo sapiens protein ( Human signal-tr... 96 2e-19
L13387-1|AAA02882.1| 288|Homo sapiens Miller-Dieker lissencepha... 95 5e-19
BC117246-1|AAI17247.1| 707|Homo sapiens F-box and WD repeat dom... 95 6e-19
BC117244-1|AAI17245.1| 707|Homo sapiens F-box and WD repeat dom... 95 6e-19
BC113421-1|AAI13422.1| 514|Homo sapiens transducin (beta)-like ... 95 6e-19
BC037320-1|AAH37320.1| 621|Homo sapiens FBXW7 protein protein. 95 6e-19
AY049984-1|AAL07271.1| 707|Homo sapiens F-box protein CDC4 prot... 95 6e-19
AY033553-1|AAK57547.1| 627|Homo sapiens F-box protein FBW7 prot... 95 6e-19
AY008274-1|AAG16640.1| 589|Homo sapiens F-box protein SEL10 pro... 95 6e-19
AK223449-1|BAD97169.1| 627|Homo sapiens F-box protein FBW7 isof... 95 6e-19
AK022956-1|BAB14331.1| 514|Homo sapiens protein ( Homo sapiens ... 95 6e-19
AK001933-1|BAA91986.1| 553|Homo sapiens protein ( Homo sapiens ... 95 6e-19
AF411972-1|AAL06291.1| 627|Homo sapiens archipelago beta form p... 95 6e-19
AF411971-1|AAL06290.1| 707|Homo sapiens archipelago alpha form ... 95 6e-19
AF383178-1|AAK60269.1| 561|Homo sapiens F-box protein FBX30 pro... 95 6e-19
AF314544-1|AAK00301.1| 514|Homo sapiens nuclear receptor co-rep... 95 6e-19
AB209725-1|BAD92962.1| 624|Homo sapiens F-box protein FBW7 isof... 95 6e-19
AF268193-1|AAG44736.1| 514|Homo sapiens IRA1 protein. 94 9e-19
Y12050-1|CAA72779.1| 340|Homo sapiens guanine nucleotide-bindin... 94 1e-18
U47924-5|AAB51313.1| 340|Homo sapiens G-protein beta-3 chain pr... 94 1e-18
M31328-1|AAA52582.1| 340|Homo sapiens GNB3 protein. 94 1e-18
BT009800-1|AAP88802.1| 340|Homo sapiens guanine nucleotide bind... 94 1e-18
BC002454-1|AAH02454.1| 340|Homo sapiens guanine nucleotide bind... 94 1e-18
BC000115-1|AAH00115.1| 340|Homo sapiens guanine nucleotide bind... 94 1e-18
AY631872-1|AAT38116.1| 340|Homo sapiens guanine nucleotide bind... 94 1e-18
AF501884-1|AAM15920.1| 340|Homo sapiens guanine nucleotide bind... 94 1e-18
AB209669-1|BAD92906.1| 1903|Homo sapiens Telomerase protein comp... 94 1e-18
AB209283-1|BAD92520.1| 327|Homo sapiens guanine nucleotide-bind... 94 1e-18
Y12781-1|CAA73319.1| 577|Homo sapiens transducin (beta) like 1 ... 93 1e-18
BC052304-1|AAH52304.1| 577|Homo sapiens transducin (beta)-like ... 93 1e-18
BC032708-1|AAH32708.1| 526|Homo sapiens TBL1X protein protein. 93 1e-18
AF490390-1|AAM97147.1| 631|Homo sapiens sperm-associated WD rep... 93 1e-18
AF310672-1|AAM63956.1| 631|Homo sapiens PF20 variant 1a protein. 93 1e-18
AB209608-1|BAD92845.1| 540|Homo sapiens transducin beta-like 1X... 93 1e-18
AB053276-1|BAB69430.1| 348|Homo sapiens TUWD12 protein. 93 1e-18
AB053266-1|BAB69057.1| 348|Homo sapiens TUWD12 protein. 93 1e-18
BC031227-1|AAH31227.2| 452|Homo sapiens WDR88 protein protein. 93 2e-18
AK131444-1|BAD18589.1| 472|Homo sapiens protein ( Homo sapiens ... 93 2e-18
BC025379-1|AAH25379.1| 571|Homo sapiens SPAG16 protein protein. 93 3e-18
U86136-1|AAC51107.1| 2627|Homo sapiens telomerase-associated pro... 92 3e-18
BC126107-1|AAI26108.1| 2627|Homo sapiens telomerase-associated p... 92 3e-18
X70476-1|CAA49900.1| 906|Homo sapiens subunit of coatomer compl... 92 5e-18
BC000326-1|AAH00326.1| 906|Homo sapiens coatomer protein comple... 92 5e-18
AK123876-1|BAC85713.1| 428|Homo sapiens protein ( Homo sapiens ... 91 8e-18
X95263-1|CAA64560.1| 919|Homo sapiens PWP2 protein. 90 2e-17
U56089-1|AAC50905.1| 919|Homo sapiens periodic tryptophan prote... 90 2e-17
U56085-1|AAC50904.1| 919|Homo sapiens periodic tryptophan prote... 90 2e-17
U53346-1|AAB08084.1| 919|Homo sapiens PWP2H protein protein. 90 2e-17
AP001753-1|BAA95553.1| 919|Homo sapiens periodic tryptophan pro... 90 2e-17
AL121993-4|CAI22739.1| 943|Homo sapiens WD repeat domain 3 prot... 90 2e-17
AF090988-1|AAC69625.1| 357|Homo sapiens U5 snRNP-specific 40 kD... 90 2e-17
AF083217-1|AAD45865.1| 943|Homo sapiens WD repeat protein WDR3 ... 90 2e-17
AB001517-2|BAA21137.1| 919|Homo sapiens PWP2 protein protein. 90 2e-17
EF011621-1|ABK41111.1| 357|Homo sapiens CDW11/WDR57 protein. 89 2e-17
BC013997-1|AAH13997.1| 353|Homo sapiens guanine nucleotide bind... 89 2e-17
BC001494-1|AAH01494.1| 357|Homo sapiens WD repeat domain 57 (U5... 89 2e-17
AL451070-1|CAH71848.1| 357|Homo sapiens WD repeat domain 57 (U5... 89 2e-17
AF501885-1|AAM15921.1| 353|Homo sapiens guanine nucleotide bind... 89 2e-17
AF300650-1|AAG18444.1| 395|Homo sapiens guanine nucleotide bind... 89 2e-17
AF017656-1|AAC63826.1| 353|Homo sapiens G protein beta 5 subuni... 89 2e-17
M36430-1|AAA63265.1| 247|Homo sapiens protein ( Human transduci... 89 4e-17
BC035409-1|AAH35409.1| 808|Homo sapiens transducin (beta)-like ... 88 7e-17
BC014007-1|AAH14007.1| 808|Homo sapiens TBL3 protein protein. 88 7e-17
BC010231-1|AAH10231.1| 808|Homo sapiens transducin (beta)-like ... 88 7e-17
BC007620-1|AAH07620.1| 570|Homo sapiens TBL3 protein protein. 88 7e-17
AF083383-1|AAC64084.1| 310|Homo sapiens 38kDa splicing factor p... 88 7e-17
AB209173-1|BAD92410.1| 832|Homo sapiens transducin beta-like 3 ... 88 7e-17
BC014988-1|AAH14988.1| 919|Homo sapiens PWP2 periodic tryptopha... 87 1e-16
BC013309-1|AAH13309.1| 919|Homo sapiens PWP2 periodic tryptopha... 87 1e-16
AK090597-1|BAC03485.1| 513|Homo sapiens protein ( Homo sapiens ... 87 1e-16
BC036713-1|AAH36713.1| 542|Homo sapiens ATG16L2 protein protein. 87 1e-16
AK093494-1|BAC04184.1| 476|Homo sapiens protein ( Homo sapiens ... 87 2e-16
AB209201-1|BAD92438.1| 466|Homo sapiens WD repeat-containing pr... 85 7e-16
AK093017-1|BAC04021.1| 619|Homo sapiens protein ( Homo sapiens ... 84 9e-16
BC026353-1|AAH26353.1| 677|Homo sapiens WD repeat domain 48 pro... 83 2e-15
BC021110-1|AAH21110.1| 421|Homo sapiens WD repeat and SOCS box-... 83 2e-15
AK074917-1|BAC11291.1| 421|Homo sapiens protein ( Homo sapiens ... 83 2e-15
AF468833-1|AAL78650.1| 677|Homo sapiens WD repeat endosomal pro... 83 2e-15
AF112205-1|AAF17193.1| 421|Homo sapiens WSB-1 protein protein. 83 2e-15
AF072880-1|AAD28808.1| 421|Homo sapiens SOCS box-containing WD ... 83 2e-15
AF069313-1|AAD20954.2| 421|Homo sapiens WSB1 protein protein. 83 2e-15
AB040882-1|BAA95973.2| 680|Homo sapiens KIAA1449 protein protein. 83 2e-15
AK222501-1|BAD96221.1| 392|Homo sapiens hypothetical protein FL... 81 8e-15
BC106004-1|AAI06005.1| 514|Homo sapiens pleiotropic regulator 1... 80 1e-14
BC020786-1|AAH20786.1| 505|Homo sapiens PLRG1 protein protein. 80 1e-14
AF044333-1|AAD09407.1| 514|Homo sapiens pleiotropic regulator 1... 80 1e-14
AK222576-1|BAD96296.1| 421|Homo sapiens WD SOCS-box protein 1 i... 80 2e-14
U63810-1|AAC24948.1| 339|Homo sapiens WD40 protein Ciao 1 protein. 79 3e-14
EF011618-1|ABK41108.1| 339|Homo sapiens CDW8/WDR39 protein. 79 3e-14
CR456802-1|CAG33083.1| 339|Homo sapiens CIAO1 protein. 79 3e-14
BC032812-1|AAH32812.1| 339|Homo sapiens cytosolic iron-sulfur p... 79 3e-14
BC001395-1|AAH01395.1| 339|Homo sapiens cytosolic iron-sulfur p... 79 3e-14
AK223257-1|BAD96977.1| 339|Homo sapiens WD40 protein Ciao1 vari... 79 3e-14
AC004020-1|AAC23493.1| 339|Homo sapiens Unknown gene product pr... 79 3e-14
BC028628-1|AAH28628.1| 375|Homo sapiens WDR71 protein protein. 79 3e-14
BC006142-1|AAH06142.2| 392|Homo sapiens WD repeat domain 71 pro... 79 3e-14
AK021910-1|BAB13933.1| 392|Homo sapiens protein ( Homo sapiens ... 79 3e-14
BC111490-1|AAI11491.1| 768|Homo sapiens BRWD3 protein protein. 79 5e-14
BC021541-1|AAH21541.1| 392|Homo sapiens WD repeat domain 71 pro... 79 5e-14
AY497047-1|AAS45472.1| 1631|Homo sapiens bromodomain and WD repe... 79 5e-14
AY497046-1|AAS45471.1| 1802|Homo sapiens bromodomain and WD repe... 79 5e-14
AL669934-1|CAI95405.1| 1802|Homo sapiens bromodomain and WD repe... 79 5e-14
AL590031-1|CAI39936.2| 1802|Homo sapiens bromodomain and WD repe... 79 5e-14
AL512504-2|CAI95143.1| 1802|Homo sapiens bromodomain and WD repe... 79 5e-14
AL031282-15|CAI20051.1| 197|Homo sapiens guanine nucleotide bin... 79 5e-14
AF106683-1|AAD43036.1| 421|Homo sapiens WSB-1 protein. 79 5e-14
AF087895-1|AAP97194.1| 375|Homo sapiens G-16 protein. 79 5e-14
AF070603-1|AAC28655.1| 207|Homo sapiens beta-subunit signal tra... 79 5e-14
AY336089-1|AAR24619.1| 271|Homo sapiens proliferation-inducing ... 78 6e-14
BC025392-1|AAH25392.1| 620|Homo sapiens WD repeat domain 16 pro... 78 8e-14
AK094847-1|BAC04435.1| 630|Homo sapiens protein ( Homo sapiens ... 78 8e-14
AK074435-1|BAB85083.1| 412|Homo sapiens protein ( Homo sapiens ... 78 8e-14
AC006011-2|AAX82033.1| 1336|Homo sapiens unknown protein. 78 8e-14
AB065281-1|BAB83743.1| 620|Homo sapiens WDR16 protein. 78 8e-14
AB044749-1|BAB32435.1| 1336|Homo sapiens WDC146 protein. 78 8e-14
U05340-1|AAA19017.1| 499|Homo sapiens p55CDC protein. 77 1e-13
DQ473545-1|ABE96834.1| 499|Homo sapiens CDC20 cell division cyc... 77 1e-13
BT007388-1|AAP36052.1| 499|Homo sapiens CDC20 cell division cyc... 77 1e-13
BC110321-1|AAI10322.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC031294-1|AAH31294.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC024257-1|AAH24257.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC015998-1|AAH15998.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC013303-1|AAH13303.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC012827-1|AAH12827.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC012803-1|AAH12803.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC010044-1|AAH10044.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC009426-1|AAH09426.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC009425-1|AAH09425.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC006272-1|AAH06272.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC001088-1|AAH01088.1| 499|Homo sapiens cell division cycle 20 ... 77 1e-13
BC000624-1|AAH00624.1| 499|Homo sapiens CDC20 protein protein. 77 1e-13
AL139289-3|CAB92757.1| 499|Homo sapiens CDC20 cell division cyc... 77 1e-13
AK074434-1|BAB85082.1| 293|Homo sapiens protein ( Homo sapiens ... 77 1e-13
AF099644-1|AAD16405.1| 499|Homo sapiens cell cycle protein CDC2... 77 1e-13
AK074217-1|BAB85020.1| 506|Homo sapiens protein ( Homo sapiens ... 77 2e-13
BC018698-1|AAH18698.1| 504|Homo sapiens PRP19/PSO4 pre-mRNA pro... 76 2e-13
BC018665-1|AAH18665.1| 504|Homo sapiens PRP19/PSO4 pre-mRNA pro... 76 2e-13
BC008719-1|AAH08719.1| 504|Homo sapiens PRP19/PSO4 pre-mRNA pro... 76 2e-13
AK131383-1|BAD18534.1| 141|Homo sapiens protein ( Homo sapiens ... 76 2e-13
AJ131186-1|CAB51857.1| 504|Homo sapiens nuclear matrix protein ... 76 2e-13
AJ005257-1|CAA06444.1| 86|Homo sapiens protein ( Homo sapiens ... 76 2e-13
BC005870-1|AAH05870.1| 315|Homo sapiens mitogen-activated prote... 76 3e-13
DQ120664-1|ABB92447.1| 456|Homo sapiens rcCDC20 protein. 75 4e-13
BC068499-1|AAH68499.1| 351|Homo sapiens THO complex 3 protein. 75 4e-13
BC067132-1|AAH67132.1| 546|Homo sapiens WDR23 protein protein. 75 4e-13
BC066325-1|AAH66325.1| 327|Homo sapiens THOC3 protein protein. 75 4e-13
BC015887-1|AAH15887.1| 404|Homo sapiens WD repeat and SOCS box-... 75 4e-13
BC006849-1|AAH06849.1| 351|Homo sapiens THO complex 3 protein. 75 4e-13
AK074296-1|BAB85041.1| 546|Homo sapiens protein ( Homo sapiens ... 75 4e-13
AF267858-1|AAG44727.1| 548|Homo sapiens GL014 protein. 75 4e-13
AF229181-1|AAF71302.1| 404|Homo sapiens CS box-containing WD pr... 75 4e-13
AF163324-1|AAF80478.1| 404|Homo sapiens WSB-2 protein. 75 4e-13
AB209073-1|BAD92310.1| 469|Homo sapiens WD repeat domain 23 iso... 75 4e-13
AL607085-2|CAI15166.1| 494|Homo sapiens novel protein protein. 74 1e-12
AB023199-1|BAA76826.2| 502|Homo sapiens KIAA0982 protein protein. 74 1e-12
AK223195-1|BAD96915.1| 315|Homo sapiens mitogen-activated prote... 74 1e-12
Z92544-1|CAM26347.1| 790|Homo sapiens WD repeat domain 24 protein. 73 2e-12
U24105-1|AAB70879.1| 1224|Homo sapiens coatomer protein protein. 73 2e-12
BC038447-1|AAH38447.1| 1233|Homo sapiens COPA protein protein. 73 2e-12
BC009761-1|AAH09761.2| 718|Homo sapiens WDR24 protein protein. 73 2e-12
BC008025-1|AAH08025.1| 790|Homo sapiens WD repeat domain 24 pro... 73 2e-12
AY358182-1|AAQ88549.1| 470|Homo sapiens SSGL9393 protein. 73 2e-12
AL513282-3|CAI12455.1| 1233|Homo sapiens coatomer protein comple... 73 2e-12
AL513282-2|CAI12454.1| 1224|Homo sapiens coatomer protein comple... 73 2e-12
AL445230-2|CAI15005.1| 1224|Homo sapiens coatomer protein comple... 73 2e-12
AL445230-1|CAI15004.1| 1233|Homo sapiens coatomer protein comple... 73 2e-12
AL163279-2|CAB90452.1| 2295|Homo sapiens homolog to cAMP respons... 73 2e-12
AJ292466-1|CAC44372.1| 2269|Homo sapiens WDR9 protein, form B p... 73 2e-12
AJ292465-1|CAC44371.1| 2320|Homo sapiens WDR9 protein, form A pr... 73 2e-12
AJ238214-1|CAC37033.2| 2269|Homo sapiens hypothetical protein pr... 73 2e-12
AB080587-1|BAD74072.1| 2199|Homo sapiens WD repeat protein WDR9-... 73 2e-12
AB080586-1|BAD74071.1| 2269|Homo sapiens WD repeat protein protein. 73 2e-12
BC029520-1|AAH29520.1| 384|Homo sapiens WDSUB1 protein protein. 73 3e-12
BC008858-1|AAH08858.2| 383|Homo sapiens WDR23 protein protein. 72 5e-12
BC126114-1|AAI26115.1| 579|Homo sapiens cell division cycle 40 ... 71 7e-12
BC117145-1|AAI17146.1| 579|Homo sapiens cell division cycle 40 ... 71 7e-12
AL671518-2|CAI13322.1| 579|Homo sapiens cell division cycle 40 ... 71 7e-12
AK222721-1|BAD96441.1| 579|Homo sapiens pre-mRNA splicing facto... 71 7e-12
AF061241-1|AAC25166.1| 542|Homo sapiens splicing factor hPRP17 ... 71 7e-12
AF038392-1|AAC39730.1| 579|Homo sapiens pre-mRNA splicing facto... 71 7e-12
AY358264-1|AAQ88631.1| 313|Homo sapiens WD40 protein protein. 71 9e-12
AF240696-1|AAF82746.1| 275|Homo sapiens WSB1 isoform 2 protein. 70 2e-11
AF433157-1|AAL28117.1| 404|Homo sapiens CDC20-like 1b protein. 70 2e-11
U02609-1|AAA18945.1| 519|Homo sapiens transducin-like protein p... 69 3e-11
X96586-1|CAA65405.1| 917|Homo sapiens FAN protein protein. 69 5e-11
BC041124-1|AAH41124.1| 917|Homo sapiens neutral sphingomyelinas... 68 6e-11
BC021905-1|AAH21905.1| 896|Homo sapiens Unknown (protein for IM... 68 6e-11
AL450327-2|CAH70884.1| 1821|Homo sapiens protein ( Human DNA seq... 68 6e-11
AL356776-2|CAI14406.1| 1821|Homo sapiens protein ( Human DNA seq... 68 6e-11
AK057039-1|BAB71353.1| 912|Homo sapiens protein ( Homo sapiens ... 68 6e-11
AJ303102-1|CAC83118.1| 1821|Homo sapiens WD repeat domain 11 pro... 68 6e-11
AB209438-1|BAD92675.1| 316|Homo sapiens PWP2 periodic tryptopha... 68 6e-11
BT020045-1|AAV38848.1| 350|Homo sapiens unr-interacting protein... 68 8e-11
BT020044-1|AAV38847.1| 350|Homo sapiens unr-interacting protein... 68 8e-11
BC062306-1|AAH62306.1| 350|Homo sapiens serine/threonine kinase... 68 8e-11
BC000162-1|AAH00162.1| 350|Homo sapiens serine/threonine kinase... 68 8e-11
AY049776-1|AAL15433.1| 350|Homo sapiens unr-interacting protein... 68 8e-11
AL833831-1|CAD38691.1| 295|Homo sapiens hypothetical protein pr... 68 8e-11
AJ010025-1|CAB38041.1| 350|Homo sapiens unr-interacting protein... 68 8e-11
AB024327-1|BAA75544.1| 350|Homo sapiens WD-40 repeat protein pr... 68 8e-11
AB013463-1|BAA86955.1| 404|Homo sapiens Fzr2 protein. 68 8e-11
BX679664-5|CAH71327.1| 919|Homo sapiens WD repeat domain 47 pro... 67 1e-10
BX679664-4|CAH71326.1| 920|Homo sapiens WD repeat domain 47 pro... 67 1e-10
BX679664-3|CAH71325.1| 891|Homo sapiens WD repeat domain 47 pro... 67 1e-10
BC039254-1|AAH39254.1| 893|Homo sapiens WDR47 protein protein. 67 1e-10
BC034964-1|AAH34964.1| 920|Homo sapiens WD repeat domain 47 pro... 67 1e-10
AL449266-4|CAI14352.1| 891|Homo sapiens WD repeat domain 47 pro... 67 1e-10
AL449266-3|CAI14353.1| 919|Homo sapiens WD repeat domain 47 pro... 67 1e-10
AL449266-2|CAI14351.1| 920|Homo sapiens WD repeat domain 47 pro... 67 1e-10
AB020700-1|BAA74916.2| 974|Homo sapiens KIAA0893 protein protein. 67 1e-10
BC107125-1|AAI07126.1| 248|Homo sapiens WDR86 protein protein. 67 1e-10
BC047921-1|AAH47921.1| 563|Homo sapiens WDR86 protein protein. 67 1e-10
BC026213-1|AAH26213.1| 529|Homo sapiens F-box and WD repeat dom... 67 1e-10
AF176022-1|AAF04528.1| 542|Homo sapiens F-box protein Fbw1b pro... 67 1e-10
AB033281-1|BAA92331.1| 542|Homo sapiens F-box and WD-repeats pr... 67 1e-10
AB033280-1|BAA92330.1| 529|Homo sapiens F-box and WD-repeats pr... 67 1e-10
AB033279-1|BAA92329.1| 508|Homo sapiens F-box and WD-repeats pr... 67 1e-10
AB014596-1|BAA31671.1| 550|Homo sapiens KIAA0696 protein protein. 67 1e-10
BC106879-1|AAI06880.1| 731|Homo sapiens STRN protein protein. 66 2e-10
BC106878-1|AAI06879.1| 755|Homo sapiens STRN protein protein. 66 2e-10
BC028387-1|AAH28387.1| 569|Homo sapiens WD repeat domain 20 pro... 66 2e-10
AK022525-1|BAB14077.1| 864|Homo sapiens protein ( Homo sapiens ... 66 2e-10
AF327354-1|AAL56014.1| 572|Homo sapiens DMR protein protein. 66 2e-10
AC007382-1|AAF66162.1| 616|Homo sapiens unknown protein. 66 2e-10
AB209148-1|BAD92385.1| 439|Homo sapiens WD repeat domain 20 iso... 66 2e-10
Y14153-1|CAA74572.1| 569|Homo sapiens beta-transducin repeats c... 66 3e-10
BC028364-1|AAH28364.1| 1061|Homo sapiens FBXW10 protein protein. 66 3e-10
BC027994-1|AAH27994.1| 605|Homo sapiens beta-transducin repeat ... 66 3e-10
AY729024-1|AAU43731.1| 1052|Homo sapiens ubiquitin ligase specif... 66 3e-10
AL627424-18|CAI41043.1| 569|Homo sapiens beta-transducin repeat... 66 3e-10
AL627424-17|CAI41042.1| 605|Homo sapiens beta-transducin repeat... 66 3e-10
AL445463-3|CAI12964.1| 569|Homo sapiens beta-transducin repeat ... 66 3e-10
AL445463-2|CAI12963.1| 605|Homo sapiens beta-transducin repeat ... 66 3e-10
AL133387-2|CAH70019.1| 569|Homo sapiens beta-transducin repeat ... 66 3e-10
AL133387-1|CAH70020.1| 605|Homo sapiens beta-transducin repeat ... 66 3e-10
AJ223814-1|CAA11560.1| 780|Homo sapiens striatin protein. 66 3e-10
AF492460-1|AAN64030.1| 1322|Homo sapiens WD repeat 17 protein. 66 3e-10
AF129530-1|AAF04464.1| 569|Homo sapiens F-box protein Fbw1A pro... 66 3e-10
AF101784-1|AAD08702.1| 605|Homo sapiens b-TRCP variant E3RS-Ika... 66 3e-10
BC023662-1|AAH23662.2| 475|Homo sapiens RRP9, small subunit (SS... 66 3e-10
BC010048-1|AAH10048.1| 475|Homo sapiens RRP9, small subunit (SS... 66 3e-10
BC009879-1|AAH09879.1| 475|Homo sapiens RRP9, small subunit (SS... 66 3e-10
BC001113-1|AAH01113.1| 475|Homo sapiens RRP9, small subunit (SS... 66 3e-10
AJ001340-1|CAA04687.1| 475|Homo sapiens U3 snoRNP associated 55... 66 3e-10
M99438-1|AAA61194.1| 772|Homo sapiens transducin-like enhancer ... 65 5e-10
AK131467-1|BAD18612.1| 419|Homo sapiens protein ( Homo sapiens ... 65 5e-10
AF242546-1|AAF60355.1| 423|Homo sapiens YTM1 protein. 65 6e-10
EF011617-1|ABK41107.1| 423|Homo sapiens CDW7/WDR12 protein. 64 1e-09
BC008082-1|AAH08082.1| 423|Homo sapiens WD repeat domain 12 pro... 64 1e-09
BC002489-1|AAH02489.1| 606|Homo sapiens WD repeat domain 1 prot... 64 1e-09
BC000201-1|AAH00201.1| 606|Homo sapiens WD repeat domain 1 prot... 64 1e-09
AL833301-1|CAD91142.1| 1340|Homo sapiens hypothetical protein pr... 64 1e-09
AL832455-1|CAD89926.1| 1308|Homo sapiens hypothetical protein pr... 64 1e-09
AL832367-1|CAD91157.1| 820|Homo sapiens hypothetical protein pr... 64 1e-09
AL832352-1|CAD91149.1| 1337|Homo sapiens hypothetical protein pr... 64 1e-09
AL832014-1|CAD91147.1| 1264|Homo sapiens hypothetical protein pr... 64 1e-09
AK223095-1|BAD96815.1| 1182|Homo sapiens WD repeat domain 10 iso... 64 1e-09
AK222897-1|BAD96617.1| 606|Homo sapiens WD repeat-containing pr... 64 1e-09
AK024435-1|BAB15725.1| 955|Homo sapiens FLJ00025 protein protein. 64 1e-09
AK001759-1|BAA91888.1| 993|Homo sapiens protein ( Homo sapiens ... 64 1e-09
AK001743-1|BAA91875.1| 423|Homo sapiens protein ( Homo sapiens ... 64 1e-09
AF209502-2|AAL40184.1| 1883|Homo sapiens ZFP106 protein. 64 1e-09
AF205632-1|AAG35666.1| 1883|Homo sapiens zinc finger protein 106... 64 1e-09
AF020056-1|AAD05044.1| 606|Homo sapiens WDR1 protein protein. 64 1e-09
AC010900-2|AAY24287.1| 423|Homo sapiens unknown protein. 64 1e-09
AB209746-1|BAD92983.1| 624|Homo sapiens WD repeat-containing pr... 64 1e-09
AB010427-1|BAA31855.2| 606|Homo sapiens NORI-1 protein. 64 1e-09
BC110334-1|AAI10335.1| 454|Homo sapiens F-box and WD repeat dom... 64 1e-09
BC018738-1|AAH18738.1| 454|Homo sapiens F-box and WD repeat dom... 64 1e-09
AL161911-3|CAI95114.1| 208|Homo sapiens F-box and WD-40 domain ... 64 1e-09
AL161911-2|CAI95113.1| 454|Homo sapiens F-box and WD-40 domain ... 64 1e-09
AK222764-1|BAD96484.1| 606|Homo sapiens WD repeat-containing pr... 64 1e-09
AK022782-1|BAB14243.1| 423|Homo sapiens protein ( Homo sapiens ... 64 1e-09
AK022781-1|BAB14242.1| 423|Homo sapiens protein ( Homo sapiens ... 64 1e-09
AK022484-1|BAB14051.1| 454|Homo sapiens protein ( Homo sapiens ... 64 1e-09
AF176698-1|AAF13226.1| 422|Homo sapiens F-box protein FBW2 prot... 64 1e-09
AF145024-1|AAP97276.1| 422|Homo sapiens MD6 protein protein. 64 1e-09
AF129531-1|AAF04465.1| 422|Homo sapiens F-box protein Fbw2 prot... 64 1e-09
AF070597-1|AAC28652.1| 127|Homo sapiens beta-subunit signal tra... 64 1e-09
AB209899-1|BAD93136.1| 967|Homo sapiens Hypothetical protein DK... 64 1e-09
M99439-1|AAA61195.1| 448|Homo sapiens transducin-like enhancer ... 63 2e-09
BC014004-1|AAH14004.1| 400|Homo sapiens WD repeat and FYVE doma... 63 2e-09
AL139183-1|CAH73431.1| 400|Homo sapiens WD repeat and FYVE doma... 63 2e-09
AL136525-1|CAH70585.1| 400|Homo sapiens WD repeat and FYVE doma... 63 2e-09
BC043247-1|AAH43247.1| 767|Homo sapiens TLE3 protein protein. 63 2e-09
BC041831-1|AAH41831.1| 772|Homo sapiens TLE3 protein protein. 63 2e-09
AY583459-1|AAS90945.1| 764|Homo sapiens transducin-like enhance... 63 2e-09
AB046767-1|BAB13373.1| 863|Homo sapiens KIAA1547 protein protein. 63 2e-09
M99436-1|AAA61193.1| 743|Homo sapiens transducin-like enhancer ... 62 3e-09
BC059405-1|AAH59405.2| 805|Homo sapiens TLE4 protein protein. 62 3e-09
BC045650-1|AAH45650.1| 704|Homo sapiens TLE4 protein protein. 62 3e-09
BC012352-1|AAH12352.1| 366|Homo sapiens WDR31 protein protein. 62 3e-09
AY583460-1|AAS90946.1| 767|Homo sapiens transducin-like enhance... 62 3e-09
AL449305-1|CAI10961.1| 367|Homo sapiens WD repeat domain 31 pro... 62 3e-09
AL445252-3|CAI13644.1| 764|Homo sapiens transducin-like enhance... 62 3e-09
AL358975-3|CAI13734.1| 764|Homo sapiens transducin-like enhance... 62 3e-09
AL353813-5|CAI41315.1| 764|Homo sapiens transducin-like enhance... 62 3e-09
AL137066-1|CAH70096.1| 367|Homo sapiens WD repeat domain 31 pro... 62 3e-09
AK093240-1|BAC04106.1| 367|Homo sapiens protein ( Homo sapiens ... 62 3e-09
AF020260-1|AAD05045.1| 534|Homo sapiens WDR1 protein protein. 62 3e-09
AB033087-1|BAA86575.1| 787|Homo sapiens KIAA1261 protein protein. 62 3e-09
L02547-1|AAA35691.1| 431|Homo sapiens cleavage stimulation fact... 62 4e-09
EF011612-1|ABK41102.1| 514|Homo sapiens CDW2/WDR26 protein. 62 4e-09
BT007138-1|AAP35802.1| 431|Homo sapiens cleavage stimulation fa... 62 4e-09
BC065934-1|AAH65934.1| 410|Homo sapiens WD repeat and FYVE doma... 62 4e-09
BC063817-1|AAH63817.1| 404|Homo sapiens WDR26 protein protein. 62 4e-09
BC052301-1|AAH52301.2| 514|Homo sapiens WD repeat domain 26 pro... 62 4e-09
BC040525-1|AAH40525.1| 410|Homo sapiens WD repeat and FYVE doma... 62 4e-09
BC031471-1|AAH31471.2| 373|Homo sapiens WDR26 protein protein. 62 4e-09
BC007425-1|AAH07425.1| 431|Homo sapiens cleavage stimulation fa... 62 4e-09
BC001011-1|AAH01011.1| 431|Homo sapiens cleavage stimulation fa... 62 4e-09
AY304473-1|AAQ74770.1| 514|Homo sapiens WD40 repeat protein 26 ... 62 4e-09
AY221751-1|AAO67709.1| 498|Homo sapiens myocardial ischemic pre... 62 4e-09
AL121914-12|CAI19328.1| 431|Homo sapiens cleavage stimulation f... 62 4e-09
AL121914-11|CAC12718.2| 345|Homo sapiens cleavage stimulation f... 62 4e-09
AK126622-1|BAC86616.1| 1060|Homo sapiens protein ( Homo sapiens ... 62 4e-09
AK024669-1|BAB14955.1| 367|Homo sapiens protein ( Homo sapiens ... 62 4e-09
AK022888-1|BAB14294.1| 410|Homo sapiens protein ( Homo sapiens ... 62 4e-09
AJ310568-1|CAC83947.1| 410|Homo sapiens phosphoinositide-bindin... 62 4e-09
AF411977-1|AAL04161.1| 410|Homo sapiens WD40- and FYVE-domain c... 62 4e-09
AC073641-1|AAY14924.1| 410|Homo sapiens unknown protein. 62 4e-09
AB209887-1|BAD93124.1| 725|Homo sapiens WD repeat domain 26 var... 62 4e-09
AB037856-1|BAA92673.1| 415|Homo sapiens KIAA1435 protein protein. 62 4e-09
BC017364-1|AAH17364.1| 743|Homo sapiens transducin-like enhance... 62 6e-09
AC007766-2|AAD38075.1| 553|Homo sapiens TLE2_HUMAN [AA 191- 743... 62 6e-09
BC034604-1|AAH34604.1| 753|Homo sapiens striatin, calmodulin bi... 61 7e-09
BC004910-1|AAH04910.2| 349|Homo sapiens STRN4 protein protein. 61 7e-09
AF212940-1|AAF29527.1| 753|Homo sapiens zinedin protein. 61 7e-09
AB209003-1|BAD92240.1| 755|Homo sapiens Zinedin variant protein. 61 7e-09
BT007115-1|AAP35779.1| 493|Homo sapiens Fzr1 protein protein. 61 1e-08
BC013413-1|AAH13413.1| 493|Homo sapiens fizzy/cell division cyc... 61 1e-08
AF083810-1|AAD52030.1| 493|Homo sapiens fizzy-related protein p... 61 1e-08
AC005787-1|AAC62835.1| 493|Homo sapiens R33374_1 protein. 61 1e-08
AB033068-1|BAA86556.1| 504|Homo sapiens KIAA1242 protein protein. 61 1e-08
BC114493-1|AAI14494.1| 1514|Homo sapiens MAPKBP1 protein protein. 60 1e-08
BC113983-1|AAI13984.1| 1231|Homo sapiens MAPKBP1 protein protein. 60 1e-08
BC028353-1|AAH28353.1| 1241|Homo sapiens intraflagellar transpor... 60 1e-08
BC022050-1|AAH22050.1| 551|Homo sapiens DMXL2 protein protein. 60 1e-08
BC012938-1|AAH12938.1| 446|Homo sapiens TBL2 protein protein. 60 1e-08
AY358518-1|AAQ88882.1| 447|Homo sapiens TBL2 protein. 60 1e-08
AL117629-1|CAB56021.1| 192|Homo sapiens hypothetical protein pr... 60 1e-08
AK074619-1|BAC11093.1| 447|Homo sapiens protein ( Homo sapiens ... 60 1e-08
AF411978-1|AAL04162.1| 400|Homo sapiens WD40- and FYVE-domain c... 60 1e-08
AF302154-1|AAG13415.1| 1241|Homo sapiens SPG protein protein. 60 1e-08
AF244930-1|AAG15427.1| 1242|Homo sapiens WDR10p protein. 60 1e-08
AF097485-1|AAF06824.1| 447|Homo sapiens transducin beta-like 2 ... 60 1e-08
AF097484-1|AAF06823.1| 447|Homo sapiens transducin beta-like 2 ... 60 1e-08
AF056183-1|AAD28083.1| 426|Homo sapiens WS beta-transducin repe... 60 1e-08
AB177850-1|BAD66828.1| 1217|Homo sapiens KIAA0596 splice variant... 60 1e-08
AB020663-1|BAA74879.2| 2237|Homo sapiens KIAA0856 protein protein. 60 1e-08
AB011168-1|BAA25522.2| 1531|Homo sapiens KIAA0596 protein protein. 60 1e-08
M99435-1|AAA61192.1| 770|Homo sapiens transducin-like enhancer ... 60 2e-08
BC027605-1|AAH27605.1| 660|Homo sapiens neural precursor cell e... 60 2e-08
BC020799-1|AAH20799.1| 532|Homo sapiens Unknown (protein for IM... 60 2e-08
BC015747-1|AAH15747.1| 770|Homo sapiens transducin-like enhance... 60 2e-08
BC010100-1|AAH10100.1| 770|Homo sapiens transducin-like enhance... 60 2e-08
AL365190-2|CAI14977.1| 770|Homo sapiens transducin-like enhance... 60 2e-08
AL353682-1|CAI12595.1| 770|Homo sapiens transducin-like enhance... 60 2e-08
AF102507-1|AAD26623.1| 377|Homo sapiens fizzy-related protein p... 60 2e-08
AB013462-1|BAA86954.1| 496|Homo sapiens Fzr1 protein. 60 2e-08
BC032551-1|AAH32551.1| 795|Homo sapiens phospholipase A2-activa... 60 2e-08
AL671518-1|CAI13321.1| 539|Homo sapiens cell division cycle 40 ... 60 2e-08
AL445068-1|CAI22519.1| 539|Homo sapiens cell division cycle 40 ... 60 2e-08
AL356133-3|CAH72641.1| 738|Homo sapiens phospholipase A2-activa... 60 2e-08
AK223544-1|BAD97264.1| 748|Homo sapiens Hypothetical protein DK... 60 2e-08
AK002143-1|BAA92105.1| 544|Homo sapiens protein ( Homo sapiens ... 60 2e-08
AJ238243-1|CAB42881.1| 738|Homo sapiens phospholipase A2 activa... 60 2e-08
AF083395-1|AAD03030.1| 738|Homo sapiens phospholipase A2-activa... 60 2e-08
AB208903-1|BAD92140.1| 501|Homo sapiens pre-mRNA splicing facto... 60 2e-08
BC139834-1|AAI39835.1| 415|Homo sapiens WDR32 protein protein. 59 4e-08
>BC010080-1|AAH10080.1| 305|Homo sapiens WD repeat domain 61
protein.
Length = 305
Score = 297 bits (728), Expect = 7e-80
Identities = 131/194 (67%), Positives = 162/194 (83%)
Query: 3 ETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
+ G D WTL FSPD +++ +G++ GK+ IFGVESGK+E LDTRGKF LS+AYSPDGKY
Sbjct: 103 DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY 162
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ASGA+DGIINIFD+A GKL+HTLEGHAM IRSL FSPDSQLL+T SDDG++K+YDV HA
Sbjct: 163 LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHA 222
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
NLAGTLSGHASWVL+VAF PD FVS S+D++V+VWD+ + C HTF +H DQVWGVK+
Sbjct: 223 NLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKY 282
Query: 183 NAESNKIISVSEDK 196
N +KI+SV +D+
Sbjct: 283 NGNGSKIVSVGDDQ 296
Score = 259 bits (635), Expect = 1e-68
Identities = 123/301 (40%), Positives = 187/301 (62%), Gaps = 11/301 (3%)
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H+D +W V + +K + + +VTG LD+LVKVW + + +L+L +LEGH+
Sbjct: 15 HDDAIWSVAWGT----------NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQ 64
Query: 233 MPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATG 292
+ VVSV +S A G++I+ I D W + FSPD +ATG
Sbjct: 65 LGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATG 124
Query: 293 GHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
H GKV ++G+ +G + LDTRGKFI+S+A+SPDG+Y+ASGA G + +FD++ GK+LH
Sbjct: 125 THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLH 184
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T+E HA +RSL FSP ++LL +AS+DGY+ +Y+++ A L L H W ++V F PD
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDD 244
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYECP 471
+S++D S++V + +HTF +H V GV++N +GSK+VSV D+ I+IY+CP
Sbjct: 245 THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304
Query: 472 I 472
I
Sbjct: 305 I 305
Score = 109 bits (263), Expect = 2e-23
Identities = 60/188 (31%), Positives = 98/188 (52%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++D S S S I ++ +E+GKQ + +D ++A+SPD +Y+A+G
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
G +NIF V GK ++L+ I S+ +SPD + L +G+ DG + ++D+ L TL
Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
GHA + S+ FSPD + V+ S D ++++D+ T H V V F +
Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
Query: 189 IISVSEDK 196
+S S DK
Sbjct: 247 FVSSSSDK 254
Score = 93.5 bits (222), Expect = 1e-18
Identities = 47/152 (30%), Positives = 80/152 (52%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
+ ++ +SPDGK++ SG+ G I IF + +GK L+ S+ +SPD + + + +
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
DG I I+DV L TL GHA + ++ F PD ++ S D +K++DV T
Sbjct: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
H V V ++ +G + VS D+ + ++D
Sbjct: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 82.2 bits (194), Expect = 4e-15
Identities = 70/312 (22%), Positives = 136/312 (43%), Gaps = 25/312 (8%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKY----IASGALDGIINIFDVAQGKL--VHTLEGHAMS 92
KQEQ D SVA+ + K + +G+LD ++ ++ +L +LEGH +
Sbjct: 10 KQEQAHDDA---IWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66
Query: 93 IRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSA 152
+ S+ S + + S D H++L+D+ + ++ ++AFSPD + +G+
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 153 DRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLV 212
V ++ ++S + KE++ G KF I+S++ P Y+ +G +D ++
Sbjct: 127 VGKVNIFGVESGK-----KEYSLDTRG-KF------ILSIA--YSPDGKYLASGAIDGII 172
Query: 213 KVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT 272
++ K LLHTLEGH MP+ S+ SPD + + +
Sbjct: 173 NIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
+S + + F PD + + V V+ + T + V ++ +G I
Sbjct: 231 HASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIV 290
Query: 333 SGAEGGSVYLFD 344
S + ++++D
Sbjct: 291 SVGDDQEIHIYD 302
>AK024754-1|BAB14986.1| 305|Homo sapiens protein ( Homo sapiens
cDNA: FLJ21101 fis, clone CAS04682. ).
Length = 305
Score = 297 bits (728), Expect = 7e-80
Identities = 131/194 (67%), Positives = 162/194 (83%)
Query: 3 ETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
+ G D WTL FSPD +++ +G++ GK+ IFGVESGK+E LDTRGKF LS+AYSPDGKY
Sbjct: 103 DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY 162
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ASGA+DGIINIFD+A GKL+HTLEGHAM IRSL FSPDSQLL+T SDDG++K+YDV HA
Sbjct: 163 LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHA 222
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
NLAGTLSGHASWVL+VAF PD FVS S+D++V+VWD+ + C HTF +H DQVWGVK+
Sbjct: 223 NLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKY 282
Query: 183 NAESNKIISVSEDK 196
N +KI+SV +D+
Sbjct: 283 NGNGSKIVSVGDDQ 296
Score = 259 bits (635), Expect = 1e-68
Identities = 123/301 (40%), Positives = 187/301 (62%), Gaps = 11/301 (3%)
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H+D +W V + +K + + +VTG LD+LVKVW + + +L+L +LEGH+
Sbjct: 15 HDDAIWSVAWGT----------NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQ 64
Query: 233 MPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATG 292
+ VVSV +S A G++I+ I D W + FSPD +ATG
Sbjct: 65 LGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATG 124
Query: 293 GHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
H GKV ++G+ +G + LDTRGKFI+S+A+SPDG+Y+ASGA G + +FD++ GK+LH
Sbjct: 125 THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLH 184
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T+E HA +RSL FSP ++LL +AS+DGY+ +Y+++ A L L H W ++V F PD
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDD 244
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYECP 471
+S++D S++V + +HTF +H V GV++N +GSK+VSV D+ I+IY+CP
Sbjct: 245 THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304
Query: 472 I 472
I
Sbjct: 305 I 305
Score = 109 bits (263), Expect = 2e-23
Identities = 60/188 (31%), Positives = 98/188 (52%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++D S S S I ++ +E+GKQ + +D ++A+SPD +Y+A+G
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
G +NIF V GK ++L+ I S+ +SPD + L +G+ DG + ++D+ L TL
Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
GHA + S+ FSPD + V+ S D ++++D+ T H V V F +
Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
Query: 189 IISVSEDK 196
+S S DK
Sbjct: 247 FVSSSSDK 254
Score = 93.5 bits (222), Expect = 1e-18
Identities = 47/152 (30%), Positives = 80/152 (52%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
+ ++ +SPDGK++ SG+ G I IF + +GK L+ S+ +SPD + + + +
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
DG I I+DV L TL GHA + ++ F PD ++ S D +K++DV T
Sbjct: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
H V V ++ +G + VS D+ + ++D
Sbjct: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 82.2 bits (194), Expect = 4e-15
Identities = 70/312 (22%), Positives = 136/312 (43%), Gaps = 25/312 (8%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKY----IASGALDGIINIFDVAQGKL--VHTLEGHAMS 92
KQEQ D SVA+ + K + +G+LD ++ ++ +L +LEGH +
Sbjct: 10 KQEQAHDDA---IWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66
Query: 93 IRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSA 152
+ S+ S + + S D H++L+D+ + ++ ++AFSPD + +G+
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 153 DRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLV 212
V ++ ++S + KE++ G KF I+S++ P Y+ +G +D ++
Sbjct: 127 VGKVNIFGVESGK-----KEYSLDTRG-KF------ILSIA--YSPDGKYLASGAIDGII 172
Query: 213 KVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT 272
++ K LLHTLEGH MP+ S+ SPD + + +
Sbjct: 173 NIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
+S + + F PD + + V V+ + T + V ++ +G I
Sbjct: 231 HASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIV 290
Query: 333 SGAEGGSVYLFD 344
S + ++++D
Sbjct: 291 SVGDDQEIHIYD 302
>AF309553-1|AAG31639.1| 305|Homo sapiens meiotic recombination
protein REC14 protein.
Length = 305
Score = 297 bits (728), Expect = 7e-80
Identities = 131/194 (67%), Positives = 162/194 (83%)
Query: 3 ETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
+ G D WTL FSPD +++ +G++ GK+ IFGVESGK+E LDTRGKF LS+AYSPDGKY
Sbjct: 103 DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY 162
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ASGA+DGIINIFD+A GKL+HTLEGHAM IRSL FSPDSQLL+T SDDG++K+YDV HA
Sbjct: 163 LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHA 222
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
NLAGTLSGHASWVL+VAF PD FVS S+D++V+VWD+ + C HTF +H DQVWGVK+
Sbjct: 223 NLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKY 282
Query: 183 NAESNKIISVSEDK 196
N +KI+SV +D+
Sbjct: 283 NGNGSKIVSVGDDQ 296
Score = 259 bits (635), Expect = 1e-68
Identities = 123/301 (40%), Positives = 187/301 (62%), Gaps = 11/301 (3%)
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H+D +W V + +K + + +VTG LD+LVKVW + + +L+L +LEGH+
Sbjct: 15 HDDAIWSVAWGT----------NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQ 64
Query: 233 MPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATG 292
+ VVSV +S A G++I+ I D W + FSPD +ATG
Sbjct: 65 LGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATG 124
Query: 293 GHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
H GKV ++G+ +G + LDTRGKFI+S+A+SPDG+Y+ASGA G + +FD++ GK+LH
Sbjct: 125 THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLH 184
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T+E HA +RSL FSP ++LL +AS+DGY+ +Y+++ A L L H W ++V F PD
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDD 244
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYECP 471
+S++D S++V + +HTF +H V GV++N +GSK+VSV D+ I+IY+CP
Sbjct: 245 THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304
Query: 472 I 472
I
Sbjct: 305 I 305
Score = 109 bits (263), Expect = 2e-23
Identities = 60/188 (31%), Positives = 98/188 (52%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++D S S S I ++ +E+GKQ + +D ++A+SPD +Y+A+G
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
G +NIF V GK ++L+ I S+ +SPD + L +G+ DG + ++D+ L TL
Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
GHA + S+ FSPD + V+ S D ++++D+ T H V V F +
Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
Query: 189 IISVSEDK 196
+S S DK
Sbjct: 247 FVSSSSDK 254
Score = 93.5 bits (222), Expect = 1e-18
Identities = 47/152 (30%), Positives = 80/152 (52%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
+ ++ +SPDGK++ SG+ G I IF + +GK L+ S+ +SPD + + + +
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
DG I I+DV L TL GHA + ++ F PD ++ S D +K++DV T
Sbjct: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
H V V ++ +G + VS D+ + ++D
Sbjct: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 82.2 bits (194), Expect = 4e-15
Identities = 70/312 (22%), Positives = 136/312 (43%), Gaps = 25/312 (8%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKY----IASGALDGIINIFDVAQGKL--VHTLEGHAMS 92
KQEQ D SVA+ + K + +G+LD ++ ++ +L +LEGH +
Sbjct: 10 KQEQAHDDA---IWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66
Query: 93 IRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSA 152
+ S+ S + + S D H++L+D+ + ++ ++AFSPD + +G+
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 153 DRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLV 212
V ++ ++S + KE++ G KF I+S++ P Y+ +G +D ++
Sbjct: 127 VGKVNIFGVESGK-----KEYSLDTRG-KF------ILSIA--YSPDGKYLASGAIDGII 172
Query: 213 KVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT 272
++ K LLHTLEGH MP+ S+ SPD + + +
Sbjct: 173 NIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
+S + + F PD + + V V+ + T + V ++ +G I
Sbjct: 231 HASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIV 290
Query: 333 SGAEGGSVYLFD 344
S + ++++D
Sbjct: 291 SVGDDQEIHIYD 302
>AF100786-1|AAP97225.1| 305|Homo sapiens G protein beta
subunit-like protein protein.
Length = 305
Score = 297 bits (728), Expect = 7e-80
Identities = 131/194 (67%), Positives = 162/194 (83%)
Query: 3 ETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
+ G D WTL FSPD +++ +G++ GK+ IFGVESGK+E LDTRGKF LS+AYSPDGKY
Sbjct: 103 DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY 162
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ASGA+DGIINIFD+A GKL+HTLEGHAM IRSL FSPDSQLL+T SDDG++K+YDV HA
Sbjct: 163 LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHA 222
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
NLAGTLSGHASWVL+VAF PD FVS S+D++V+VWD+ + C HTF +H DQVWGVK+
Sbjct: 223 NLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKY 282
Query: 183 NAESNKIISVSEDK 196
N +KI+SV +D+
Sbjct: 283 NGNGSKIVSVGDDQ 296
Score = 259 bits (635), Expect = 1e-68
Identities = 123/301 (40%), Positives = 187/301 (62%), Gaps = 11/301 (3%)
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H+D +W V + +K + + +VTG LD+LVKVW + + +L+L +LEGH+
Sbjct: 15 HDDAIWSVAWGT----------NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQ 64
Query: 233 MPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATG 292
+ VVSV +S A G++I+ I D W + FSPD +ATG
Sbjct: 65 LGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATG 124
Query: 293 GHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
H GKV ++G+ +G + LDTRGKFI+S+A+SPDG+Y+ASGA G + +FD++ GK+LH
Sbjct: 125 THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLH 184
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T+E HA +RSL FSP ++LL +AS+DGY+ +Y+++ A L L H W ++V F PD
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDD 244
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYECP 471
+S++D S++V + +HTF +H V GV++N +GSK+VSV D+ I+IY+CP
Sbjct: 245 THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304
Query: 472 I 472
I
Sbjct: 305 I 305
Score = 109 bits (263), Expect = 2e-23
Identities = 60/188 (31%), Positives = 98/188 (52%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++D S S S I ++ +E+GKQ + +D ++A+SPD +Y+A+G
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
G +NIF V GK ++L+ I S+ +SPD + L +G+ DG + ++D+ L TL
Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
GHA + S+ FSPD + V+ S D ++++D+ T H V V F +
Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
Query: 189 IISVSEDK 196
+S S DK
Sbjct: 247 FVSSSSDK 254
Score = 93.5 bits (222), Expect = 1e-18
Identities = 47/152 (30%), Positives = 80/152 (52%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
+ ++ +SPDGK++ SG+ G I IF + +GK L+ S+ +SPD + + + +
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
DG I I+DV L TL GHA + ++ F PD ++ S D +K++DV T
Sbjct: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
H V V ++ +G + VS D+ + ++D
Sbjct: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 82.2 bits (194), Expect = 4e-15
Identities = 70/312 (22%), Positives = 136/312 (43%), Gaps = 25/312 (8%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKY----IASGALDGIINIFDVAQGKL--VHTLEGHAMS 92
KQEQ D SVA+ + K + +G+LD ++ ++ +L +LEGH +
Sbjct: 10 KQEQAHDDA---IWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66
Query: 93 IRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSA 152
+ S+ S + + S D H++L+D+ + ++ ++AFSPD + +G+
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 153 DRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLV 212
V ++ ++S + KE++ G KF I+S++ P Y+ +G +D ++
Sbjct: 127 VGKVNIFGVESGK-----KEYSLDTRG-KF------ILSIA--YSPDGKYLASGAIDGII 172
Query: 213 KVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT 272
++ K LLHTLEGH MP+ S+ SPD + + +
Sbjct: 173 NIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
+S + + F PD + + V V+ + T + V ++ +G I
Sbjct: 231 HASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIV 290
Query: 333 SGAEGGSVYLFD 344
S + ++++D
Sbjct: 291 SVGDDQEIHIYD 302
>CR457333-1|CAG33614.1| 305|Homo sapiens REC14 protein.
Length = 305
Score = 295 bits (723), Expect = 3e-79
Identities = 130/194 (67%), Positives = 160/194 (82%)
Query: 3 ETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
+ G D WTL FSPD +++ +G++ GK+ IFGVESGK+E LDTRGKF LS+AYSPDGKY
Sbjct: 103 DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY 162
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ASGA+DGIINIFD+A GKL+HTLEGHAM IRSL FSPDSQLL+T SDDG++K+YDV HA
Sbjct: 163 LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHA 222
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
NLAGTL GHASWVL+VAF PD FVS S+D+ V+VWD+ + C HTF +H DQVWGVK+
Sbjct: 223 NLAGTLGGHASWVLNVAFCPDDTHFVSSSSDKNVKVWDVGTRTCVHTFFDHQDQVWGVKY 282
Query: 183 NAESNKIISVSEDK 196
N +KI+SV +D+
Sbjct: 283 NGNGSKIVSVGDDQ 296
Score = 258 bits (631), Expect = 4e-68
Identities = 122/301 (40%), Positives = 187/301 (62%), Gaps = 11/301 (3%)
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H+D +W V + +K + + +VTG LD+LVKVW + + +L+L +LEGH+
Sbjct: 15 HDDAIWSVAWGT----------NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQ 64
Query: 233 MPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATG 292
+ VVSV +S A G++I+ I D W + FSPD +ATG
Sbjct: 65 LGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATG 124
Query: 293 GHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
H GKV ++G+ +G + LDTRGKFI+S+A+SPDG+Y+ASGA G + +FD++ GK+LH
Sbjct: 125 THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLH 184
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDG 411
T+E HA +RSL FSP ++LL +AS+DGY+ +Y+++ A L L H W ++V F PD
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLGGHASWVLNVAFCPDD 244
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYECP 471
+S++D +++V + +HTF +H V GV++N +GSK+VSV D+ I+IY+CP
Sbjct: 245 THFVSSSSDKNVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304
Query: 472 I 472
I
Sbjct: 305 I 305
Score = 109 bits (261), Expect = 3e-23
Identities = 60/188 (31%), Positives = 98/188 (52%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++D S S S I ++ +E+GKQ + +D ++A+SPD +Y+A+G
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
G +NIF V GK ++L+ I S+ +SPD + L +G+ DG + ++D+ L TL
Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL 186
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
GHA + S+ FSPD + V+ S D ++++D+ T H V V F +
Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLGGHASWVLNVAFCPDDTH 246
Query: 189 IISVSEDK 196
+S S DK
Sbjct: 247 FVSSSSDK 254
Score = 93.5 bits (222), Expect = 1e-18
Identities = 47/152 (30%), Positives = 81/152 (53%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
+ ++ +SPDGK++ SG+ G I IF + +GK L+ S+ +SPD + + + +
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
DG I I+DV L TL GHA + ++ F PD ++ S D ++K++DV T
Sbjct: 211 DGYIKIYDVQHANLAGTLGGHASWVLNVAFCPDDTHFVSSSSDKNVKVWDVGTRTCVHTF 270
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
H V V ++ +G + VS D+ + ++D
Sbjct: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 81.4 bits (192), Expect = 6e-15
Identities = 70/312 (22%), Positives = 136/312 (43%), Gaps = 25/312 (8%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKY----IASGALDGIINIFDVAQGKL--VHTLEGHAMS 92
KQEQ D SVA+ + K + +G+LD ++ ++ +L +LEGH +
Sbjct: 10 KQEQAHDDA---IWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66
Query: 93 IRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSA 152
+ S+ S + + S D H++L+D+ + ++ ++AFSPD + +G+
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 153 DRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLV 212
V ++ ++S + KE++ G KF I+S++ P Y+ +G +D ++
Sbjct: 127 VGKVNIFGVESGK-----KEYSLDTRG-KF------ILSIA--YSPDGKYLASGAIDGII 172
Query: 213 KVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT 272
++ K LLHTLEGH MP+ S+ SPD + + +
Sbjct: 173 NIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLGG 230
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
+S + + F PD + + V V+ + T + V ++ +G I
Sbjct: 231 HASWVLNVAFCPDDTHFVSSSSDKNVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIV 290
Query: 333 SGAEGGSVYLFD 344
S + ++++D
Sbjct: 291 SVGDDQEIHIYD 302
>AF127799-1|AAP97249.1| 305|Homo sapiens G protein beta
subunit-like protein protein.
Length = 305
Score = 288 bits (706), Expect = 3e-77
Identities = 129/194 (66%), Positives = 160/194 (82%)
Query: 3 ETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
+ G D WTL FSPD +++ +G++ GK+ IFGVESGK+E LDTRGKF LS+AYSPDGKY
Sbjct: 103 DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY 162
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ASGA+DGIINIF +A GKL+HTLEGHAM IRSL FSPDSQLL+T SDDG++K+YDV HA
Sbjct: 163 LASGAIDGIINIFAIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHA 222
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
NLAGTLSGHASWVL+VAF PD FVS S+D++V+V D+ + C HTF +H DQVWGVK+
Sbjct: 223 NLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVRDVGTRTCVHTFFDHQDQVWGVKY 282
Query: 183 NAESNKIISVSEDK 196
N +KI+SV +D+
Sbjct: 283 NGNGSKIVSVGDDQ 296
Score = 256 bits (628), Expect = 1e-67
Identities = 122/301 (40%), Positives = 186/301 (61%), Gaps = 11/301 (3%)
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H+D +W V + +K + + +VTG LD+LVKVW + + +L+L +LEGH+
Sbjct: 15 HDDAIWSVAWGT----------NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQ 64
Query: 233 MPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATG 292
+ VVSV +S A G++I+ I D W + FSPD +ATG
Sbjct: 65 LGVVSVDISHTLPIAASSSLDAHIRLRDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATG 124
Query: 293 GHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
H GKV ++G+ +G + LDTRGKFI+S+A+SPDG+Y+ASGA G + +F ++ GK+LH
Sbjct: 125 THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFAIATGKLLH 184
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T+E HA +RSL FSP ++LL +AS+DGY+ +Y+++ A L L H W ++V F PD
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDD 244
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYECP 471
+S++D S++V + +HTF +H V GV++N +GSK+VSV D+ I+IY+CP
Sbjct: 245 THFVSSSSDKSVKVRDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304
Query: 472 I 472
I
Sbjct: 305 I 305
Score = 105 bits (251), Expect = 5e-22
Identities = 59/188 (31%), Positives = 96/188 (51%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++D S S S I + +E+GKQ + +D ++A+SPD +Y+A+G
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLRDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
G +NIF V GK ++L+ I S+ +SPD + L +G+ DG + ++ + L TL
Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFAIATGKLLHTL 186
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
GHA + S+ FSPD + V+ S D ++++D+ T H V V F +
Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH 246
Query: 189 IISVSEDK 196
+S S DK
Sbjct: 247 FVSSSSDK 254
Score = 92.3 bits (219), Expect = 3e-18
Identities = 47/152 (30%), Positives = 79/152 (51%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
+ ++ +SPDGK++ SG+ G I IF + +GK L+ S+ +SPD + + + +
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFAIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
DG I I+DV L TL GHA + ++ F PD ++ S D +K+ DV T
Sbjct: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVRDVGTRTCVHTF 270
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
H V V ++ +G + VS D+ + ++D
Sbjct: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 79.4 bits (187), Expect = 3e-14
Identities = 70/312 (22%), Positives = 135/312 (43%), Gaps = 25/312 (8%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKY----IASGALDGIINIFDVAQGKL--VHTLEGHAMS 92
KQEQ D SVA+ + K + +G+LD ++ ++ +L +LEGH +
Sbjct: 10 KQEQAHDDA---IWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66
Query: 93 IRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSA 152
+ S+ S + + S D H++L D+ + ++ ++AFSPD + +G+
Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLRDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTH 126
Query: 153 DRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLV 212
V ++ ++S + KE++ G KF I+S++ P Y+ +G +D ++
Sbjct: 127 VGKVNIFGVESGK-----KEYSLDTRG-KF------ILSIA--YSPDGKYLASGAIDGII 172
Query: 213 KVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT 272
+++ K LLHTLEGH MP+ S+ SPD + + +
Sbjct: 173 NIFAIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
+S + + F PD + + V V + T + V ++ +G I
Sbjct: 231 HASWVLNVAFCPDDTHFVSSSSDKSVKVRDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIV 290
Query: 333 SGAEGGSVYLFD 344
S + ++++D
Sbjct: 291 SVGDDQEIHIYD 302
>BC012075-1|AAH12075.1| 485|Homo sapiens notchless homolog 1
(Drosophila) protein.
Length = 485
Score = 138 bits (335), Expect = 3e-32
Identities = 100/390 (25%), Positives = 183/390 (46%), Gaps = 25/390 (6%)
Query: 44 LDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ 103
L+ + +SVA+SP GKY+ASG+ D + +D++ T +GH + S+ +SPD +
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGK 169
Query: 104 LLLTGSDDGHMKLYDVVHANLAG-TLSGHASWVLSVAF-----SPDGKRFVSGSADRTVR 157
L +G +G + L+D G TL+GH+ W+ +++ +P+ + S S D +VR
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
Query: 158 VWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSY 217
+WD + +C+ H V +++ + + S S+D+ +KVW
Sbjct: 230 IWDTTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQDR--------------TIKVWRA 274
Query: 218 ENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDM 277
+ L TL+GH V ++A+S D ++E++ +
Sbjct: 275 HDG--VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSR 332
Query: 278 WKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDT-RGKFIMSVAWSPDGRYIASGAE 336
+ +V ++ +G + ++ T I V +SPD R +AS +
Sbjct: 333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S+ L+D GK L ++ H AV +A+S ++LL S S+D + V+++++ L L
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452
Query: 397 -DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
H +V +SPDGQR+A+ D +R+
Sbjct: 453 PGHADEVYAVDWSPDGQRVASGGKDKCLRI 482
Score = 106 bits (255), Expect = 1e-22
Identities = 88/400 (22%), Positives = 174/400 (43%), Gaps = 18/400 (4%)
Query: 74 IFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA 132
IF V A + +LEGH+ ++ S+ FSP + L +GS D ++ +D+ T GH
Sbjct: 97 IFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHR 156
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDS-MQCQHTFKEHNDQVWGVKFNAESNKIIS 191
WVLS+++SPDGK+ SG + + +WD + Q T H+ + G+ +
Sbjct: 157 HWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWE-------- 208
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
P Y+ + D V++W + E + L GH V + DG +
Sbjct: 209 -PLHANPECRYVASSSKDGSVRIWDTTAGRCERI--LTGHTQSVTCLRWGGDG-LLYSAS 264
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY-GIINGTVDK 310
G R +Q + + S D + + +V + G++ +
Sbjct: 265 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQE 324
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM-LHTIEAHAQAVRSLAFSPK 369
L R ++ + SG++ +++L+ ++ K L + H + + FSP
Sbjct: 325 -LKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD 383
Query: 370 TKLLASASNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
++++ASAS D + +++ + L + H + +S D + + + ++D +++V +
Sbjct: 384 SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ ++ H V V ++ DG ++ S KDK + I+
Sbjct: 444 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 101 bits (243), Expect = 4e-21
Identities = 90/363 (24%), Positives = 163/363 (44%), Gaps = 38/363 (10%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP GK++ SGS + + + + + LS+++SPDGK +ASG
Sbjct: 117 VISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCK 176
Query: 69 DGIINIFDVAQGKLV-HTLEGHAMSIRSLCF-----SPDSQLLLTGSDDGHMKLYDVVHA 122
+G I ++D + GK V TL GH+ I L + +P+ + + + S DG ++++D
Sbjct: 177 NGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAG 236
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL-DSMQCQHTFKEHNDQV---- 177
L+GH V + + DG + S S DRT++VW D + C+ T + H V
Sbjct: 237 RCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAHDGVLCR-TLQGHGHWVNTMA 294
Query: 178 ----WGVKFNAESNKIISVS-----------EDKGPSKDYIVTG-GLDNLVK-------- 213
+ ++ A SV+ +++ S+ +V G G + LV
Sbjct: 295 LSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLF 354
Query: 214 VWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTD 273
+WS +K L + GH+ + V SPD +A G+ + ++
Sbjct: 355 LWSPAEDKKPLTR-MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGH 413
Query: 274 SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ +++I +S D + +G + V+ + + L + +V WSPDG+ +AS
Sbjct: 414 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVAS 473
Query: 334 GAE 336
G +
Sbjct: 474 GGK 476
Score = 95.9 bits (228), Expect = 3e-19
Identities = 48/142 (33%), Positives = 83/142 (58%), Gaps = 1/142 (0%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGIINIFDV 77
+ ++SGS+ + ++ K+ T + ++ V +SPD + +AS + D I ++D
Sbjct: 342 ERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDG 401
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLS 137
GK + +L GH ++ + +S DS+LL++GS D +K++DV LA L GHA V +
Sbjct: 402 RTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYA 461
Query: 138 VAFSPDGKRFVSGSADRTVRVW 159
V +SPDG+R SG D+ +R+W
Sbjct: 462 VDWSPDGQRVASGGKDKCLRIW 483
Score = 80.2 bits (189), Expect = 1e-14
Identities = 77/350 (22%), Positives = 144/350 (41%), Gaps = 23/350 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
+L GH+ V+SVAFSP GK SGS D TVR WDL + T K H V + ++ +
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA-----VS 241
K+ S G + + +W K ++ TL GH + ++ +
Sbjct: 169 KKLAS--------------GCKNGQILLWDPSTGK-QVGRTLAGHSKWITGLSWEPLHAN 213
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
P+ +A G+ R + + + + + DG + + + V+
Sbjct: 214 PECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVW 272
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+G + + L G ++ ++A S D E + L ++ A +
Sbjct: 273 RAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSR 332
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
+L + L S S+D + +++ + L H+ V FSPD + +A+++
Sbjct: 333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392
Query: 420 DGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
D SI++ + L + H V + ++AD LVS S D ++ +++
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Score = 67.3 bits (157), Expect = 1e-10
Identities = 71/295 (24%), Positives = 123/295 (41%), Gaps = 27/295 (9%)
Query: 4 TGLTDVWT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TGL+ W L +P+ ++V S S G + I+ +G+ E++L + + + DG
Sbjct: 203 TGLS--WEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ S + D I ++ G L TL+GH + ++ S D L TG+ + V
Sbjct: 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTD-YALRTGAFEPAEA--SVNPQ 316
Query: 123 NLAGTLSGHASWVLS---VAFSPDGKRFVSGSADRTVRVWD-LDSMQCQHTFKEHNDQVW 178
+L G+L LS + +R VSGS D T+ +W + + H +
Sbjct: 317 DLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALIN 376
Query: 179 GVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSV 238
V F+ +S + S S DK +K+W K L +L GH V +
Sbjct: 377 QVLFSPDSRIVASASFDKS--------------IKLWDGRTGK--YLASLRGHVAAVYQI 420
Query: 239 AVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
A S D + + ++ + +++ + +SPDG +VA+GG
Sbjct: 421 AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 475
Score = 57.2 bits (132), Expect = 1e-07
Identities = 31/104 (29%), Positives = 53/104 (50%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPD + V S S I ++ +GK L +A+S D + + SG+ D +
Sbjct: 380 FSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
++DV KL L GHA + ++ +SPD Q + +G D ++++
Sbjct: 440 VWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
H +SV FSP G+ +A+ + D ++R L T + H H V + ++ DG KL
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLA 172
Query: 458 SVSKDKSINIYECPIPPKSAKKV 480
S K+ I +++ P + K+V
Sbjct: 173 SGCKNGQILLWD----PSTGKQV 191
Score = 37.9 bits (84), Expect = 0.078
Identities = 19/67 (28%), Positives = 37/67 (55%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + +S D + ++SGS+ + ++ V++ K L +V +SPDG+ +ASG
Sbjct: 417 VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGK 476
Query: 69 DGIINIF 75
D + I+
Sbjct: 477 DKCLRIW 483
>BC002884-1|AAH02884.2| 484|Homo sapiens NLE1 protein protein.
Length = 484
Score = 138 bits (335), Expect = 3e-32
Identities = 100/390 (25%), Positives = 183/390 (46%), Gaps = 25/390 (6%)
Query: 44 LDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ 103
L+ + +SVA+SP GKY+ASG+ D + +D++ T +GH + S+ +SPD +
Sbjct: 109 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGK 168
Query: 104 LLLTGSDDGHMKLYDVVHANLAG-TLSGHASWVLSVAF-----SPDGKRFVSGSADRTVR 157
L +G +G + L+D G TL+GH+ W+ +++ +P+ + S S D +VR
Sbjct: 169 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 228
Query: 158 VWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSY 217
+WD + +C+ H V +++ + + S S+D+ +KVW
Sbjct: 229 IWDTTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQDR--------------TIKVWRA 273
Query: 218 ENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDM 277
+ L TL+GH V ++A+S D ++E++ +
Sbjct: 274 HDG--VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSR 331
Query: 278 WKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDT-RGKFIMSVAWSPDGRYIASGAE 336
+ +V ++ +G + ++ T I V +SPD R +AS +
Sbjct: 332 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 391
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S+ L+D GK L ++ H AV +A+S ++LL S S+D + V+++++ L L
Sbjct: 392 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 451
Query: 397 -DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
H +V +SPDGQR+A+ D +R+
Sbjct: 452 PGHADEVYAVDWSPDGQRVASGGKDKCLRI 481
Score = 106 bits (255), Expect = 1e-22
Identities = 88/400 (22%), Positives = 174/400 (43%), Gaps = 18/400 (4%)
Query: 74 IFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA 132
IF V A + +LEGH+ ++ S+ FSP + L +GS D ++ +D+ T GH
Sbjct: 96 IFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHR 155
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDS-MQCQHTFKEHNDQVWGVKFNAESNKIIS 191
WVLS+++SPDGK+ SG + + +WD + Q T H+ + G+ +
Sbjct: 156 HWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWE-------- 207
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
P Y+ + D V++W + E + L GH V + DG +
Sbjct: 208 -PLHANPECRYVASSSKDGSVRIWDTTAGRCERI--LTGHTQSVTCLRWGGDG-LLYSAS 263
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY-GIINGTVDK 310
G R +Q + + S D + + +V + G++ +
Sbjct: 264 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQE 323
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM-LHTIEAHAQAVRSLAFSPK 369
L R ++ + SG++ +++L+ ++ K L + H + + FSP
Sbjct: 324 -LKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD 382
Query: 370 TKLLASASNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
++++ASAS D + +++ + L + H + +S D + + + ++D +++V +
Sbjct: 383 SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 442
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ ++ H V V ++ DG ++ S KDK + I+
Sbjct: 443 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 482
Score = 101 bits (243), Expect = 4e-21
Identities = 90/363 (24%), Positives = 163/363 (44%), Gaps = 38/363 (10%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP GK++ SGS + + + + + LS+++SPDGK +ASG
Sbjct: 116 VISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCK 175
Query: 69 DGIINIFDVAQGKLV-HTLEGHAMSIRSLCF-----SPDSQLLLTGSDDGHMKLYDVVHA 122
+G I ++D + GK V TL GH+ I L + +P+ + + + S DG ++++D
Sbjct: 176 NGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAG 235
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL-DSMQCQHTFKEHNDQV---- 177
L+GH V + + DG + S S DRT++VW D + C+ T + H V
Sbjct: 236 RCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAHDGVLCR-TLQGHGHWVNTMA 293
Query: 178 ----WGVKFNAESNKIISVS-----------EDKGPSKDYIVTG-GLDNLVK-------- 213
+ ++ A SV+ +++ S+ +V G G + LV
Sbjct: 294 LSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLF 353
Query: 214 VWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTD 273
+WS +K L + GH+ + V SPD +A G+ + ++
Sbjct: 354 LWSPAEDKKPLTR-MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGH 412
Query: 274 SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ +++I +S D + +G + V+ + + L + +V WSPDG+ +AS
Sbjct: 413 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVAS 472
Query: 334 GAE 336
G +
Sbjct: 473 GGK 475
Score = 95.9 bits (228), Expect = 3e-19
Identities = 48/142 (33%), Positives = 83/142 (58%), Gaps = 1/142 (0%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGIINIFDV 77
+ ++SGS+ + ++ K+ T + ++ V +SPD + +AS + D I ++D
Sbjct: 341 ERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDG 400
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLS 137
GK + +L GH ++ + +S DS+LL++GS D +K++DV LA L GHA V +
Sbjct: 401 RTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYA 460
Query: 138 VAFSPDGKRFVSGSADRTVRVW 159
V +SPDG+R SG D+ +R+W
Sbjct: 461 VDWSPDGQRVASGGKDKCLRIW 482
Score = 80.2 bits (189), Expect = 1e-14
Identities = 77/350 (22%), Positives = 144/350 (41%), Gaps = 23/350 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
+L GH+ V+SVAFSP GK SGS D TVR WDL + T K H V + ++ +
Sbjct: 108 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 167
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA-----VS 241
K+ S G + + +W K ++ TL GH + ++ +
Sbjct: 168 KKLAS--------------GCKNGQILLWDPSTGK-QVGRTLAGHSKWITGLSWEPLHAN 212
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
P+ +A G+ R + + + + + DG + + + V+
Sbjct: 213 PECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVW 271
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+G + + L G ++ ++A S D E + L ++ A +
Sbjct: 272 RAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSR 331
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
+L + L S S+D + +++ + L H+ V FSPD + +A+++
Sbjct: 332 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 391
Query: 420 DGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
D SI++ + L + H V + ++AD LVS S D ++ +++
Sbjct: 392 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 441
Score = 67.3 bits (157), Expect = 1e-10
Identities = 71/295 (24%), Positives = 123/295 (41%), Gaps = 27/295 (9%)
Query: 4 TGLTDVWT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TGL+ W L +P+ ++V S S G + I+ +G+ E++L + + + DG
Sbjct: 202 TGLS--WEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 258
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ S + D I ++ G L TL+GH + ++ S D L TG+ + V
Sbjct: 259 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTD-YALRTGAFEPAEA--SVNPQ 315
Query: 123 NLAGTLSGHASWVLS---VAFSPDGKRFVSGSADRTVRVWD-LDSMQCQHTFKEHNDQVW 178
+L G+L LS + +R VSGS D T+ +W + + H +
Sbjct: 316 DLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALIN 375
Query: 179 GVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSV 238
V F+ +S + S S DK +K+W K L +L GH V +
Sbjct: 376 QVLFSPDSRIVASASFDKS--------------IKLWDGRTGK--YLASLRGHVAAVYQI 419
Query: 239 AVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
A S D + + ++ + +++ + +SPDG +VA+GG
Sbjct: 420 AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 474
Score = 57.2 bits (132), Expect = 1e-07
Identities = 31/104 (29%), Positives = 53/104 (50%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPD + V S S I ++ +GK L +A+S D + + SG+ D +
Sbjct: 379 FSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 438
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
++DV KL L GHA + ++ +SPD Q + +G D ++++
Sbjct: 439 VWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 482
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
H +SV FSP G+ +A+ + D ++R L T + H H V + ++ DG KL
Sbjct: 112 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLA 171
Query: 458 SVSKDKSINIYECPIPPKSAKKV 480
S K+ I +++ P + K+V
Sbjct: 172 SGCKNGQILLWD----PSTGKQV 190
Score = 37.9 bits (84), Expect = 0.078
Identities = 19/67 (28%), Positives = 37/67 (55%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + +S D + ++SGS+ + ++ V++ K L +V +SPDG+ +ASG
Sbjct: 416 VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGK 475
Query: 69 DGIINIF 75
D + I+
Sbjct: 476 DKCLRIW 482
>AK001320-1|BAA91621.1| 485|Homo sapiens protein ( Homo sapiens
cDNA FLJ10458 fis, clone NT2RP1001457, highly similar to
Homo sapiens partial mRNA for beta-transducin family
protein. ).
Length = 485
Score = 138 bits (335), Expect = 3e-32
Identities = 100/390 (25%), Positives = 183/390 (46%), Gaps = 25/390 (6%)
Query: 44 LDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ 103
L+ + +SVA+SP GKY+ASG+ D + +D++ T +GH + S+ +SPD +
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGK 169
Query: 104 LLLTGSDDGHMKLYDVVHANLAG-TLSGHASWVLSVAF-----SPDGKRFVSGSADRTVR 157
L +G +G + L+D G TL+GH+ W+ +++ +P+ + S S D +VR
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
Query: 158 VWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSY 217
+WD + +C+ H V +++ + + S S+D+ +KVW
Sbjct: 230 IWDTTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQDR--------------TIKVWRA 274
Query: 218 ENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDM 277
+ L TL+GH V ++A+S D ++E++ +
Sbjct: 275 HDG--VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSR 332
Query: 278 WKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDT-RGKFIMSVAWSPDGRYIASGAE 336
+ +V ++ +G + ++ T I V +SPD R +AS +
Sbjct: 333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S+ L+D GK L ++ H AV +A+S ++LL S S+D + V+++++ L L
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452
Query: 397 -DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
H +V +SPDGQR+A+ D +R+
Sbjct: 453 PGHADEVYAVDWSPDGQRVASGGKDKCLRI 482
Score = 106 bits (255), Expect = 1e-22
Identities = 88/400 (22%), Positives = 174/400 (43%), Gaps = 18/400 (4%)
Query: 74 IFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA 132
IF V A + +LEGH+ ++ S+ FSP + L +GS D ++ +D+ T GH
Sbjct: 97 IFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHR 156
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDS-MQCQHTFKEHNDQVWGVKFNAESNKIIS 191
WVLS+++SPDGK+ SG + + +WD + Q T H+ + G+ +
Sbjct: 157 HWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWE-------- 208
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
P Y+ + D V++W + E + L GH V + DG +
Sbjct: 209 -PLHANPECRYVASSSKDGSVRIWDTTAGRCERI--LTGHTQSVTCLRWGGDG-LLYSAS 264
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY-GIINGTVDK 310
G R +Q + + S D + + +V + G++ +
Sbjct: 265 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQE 324
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM-LHTIEAHAQAVRSLAFSPK 369
L R ++ + SG++ +++L+ ++ K L + H + + FSP
Sbjct: 325 -LKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD 383
Query: 370 TKLLASASNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
++++ASAS D + +++ + L + H + +S D + + + ++D +++V +
Sbjct: 384 SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ ++ H V V ++ DG ++ S KDK + I+
Sbjct: 444 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 101 bits (243), Expect = 4e-21
Identities = 90/363 (24%), Positives = 163/363 (44%), Gaps = 38/363 (10%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP GK++ SGS + + + + + LS+++SPDGK +ASG
Sbjct: 117 VISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCK 176
Query: 69 DGIINIFDVAQGKLV-HTLEGHAMSIRSLCF-----SPDSQLLLTGSDDGHMKLYDVVHA 122
+G I ++D + GK V TL GH+ I L + +P+ + + + S DG ++++D
Sbjct: 177 NGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAG 236
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL-DSMQCQHTFKEHNDQV---- 177
L+GH V + + DG + S S DRT++VW D + C+ T + H V
Sbjct: 237 RCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAHDGVLCR-TLQGHGHWVNTMA 294
Query: 178 ----WGVKFNAESNKIISVS-----------EDKGPSKDYIVTG-GLDNLVK-------- 213
+ ++ A SV+ +++ S+ +V G G + LV
Sbjct: 295 LSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLF 354
Query: 214 VWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTD 273
+WS +K L + GH+ + V SPD +A G+ + ++
Sbjct: 355 LWSPAEDKKPLTR-MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGH 413
Query: 274 SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ +++I +S D + +G + V+ + + L + +V WSPDG+ +AS
Sbjct: 414 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVAS 473
Query: 334 GAE 336
G +
Sbjct: 474 GGK 476
Score = 95.9 bits (228), Expect = 3e-19
Identities = 48/142 (33%), Positives = 83/142 (58%), Gaps = 1/142 (0%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGIINIFDV 77
+ ++SGS+ + ++ K+ T + ++ V +SPD + +AS + D I ++D
Sbjct: 342 ERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDG 401
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLS 137
GK + +L GH ++ + +S DS+LL++GS D +K++DV LA L GHA V +
Sbjct: 402 RTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYA 461
Query: 138 VAFSPDGKRFVSGSADRTVRVW 159
V +SPDG+R SG D+ +R+W
Sbjct: 462 VDWSPDGQRVASGGKDKCLRIW 483
Score = 80.2 bits (189), Expect = 1e-14
Identities = 77/350 (22%), Positives = 144/350 (41%), Gaps = 23/350 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
+L GH+ V+SVAFSP GK SGS D TVR WDL + T K H V + ++ +
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA-----VS 241
K+ S G + + +W K ++ TL GH + ++ +
Sbjct: 169 KKLAS--------------GCKNGQILLWDPSTGK-QVGRTLAGHSKWITGLSWEPLHAN 213
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
P+ +A G+ R + + + + + DG + + + V+
Sbjct: 214 PECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVW 272
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+G + + L G ++ ++A S D E + L ++ A +
Sbjct: 273 RAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSR 332
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
+L + L S S+D + +++ + L H+ V FSPD + +A+++
Sbjct: 333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392
Query: 420 DGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
D SI++ + L + H V + ++AD LVS S D ++ +++
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Score = 67.3 bits (157), Expect = 1e-10
Identities = 71/295 (24%), Positives = 123/295 (41%), Gaps = 27/295 (9%)
Query: 4 TGLTDVWT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TGL+ W L +P+ ++V S S G + I+ +G+ E++L + + + DG
Sbjct: 203 TGLS--WEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ S + D I ++ G L TL+GH + ++ S D L TG+ + V
Sbjct: 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTD-YALRTGAFEPAEA--SVNPQ 316
Query: 123 NLAGTLSGHASWVLS---VAFSPDGKRFVSGSADRTVRVWD-LDSMQCQHTFKEHNDQVW 178
+L G+L LS + +R VSGS D T+ +W + + H +
Sbjct: 317 DLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALIN 376
Query: 179 GVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSV 238
V F+ +S + S S DK +K+W K L +L GH V +
Sbjct: 377 QVLFSPDSRIVASASFDKS--------------IKLWDGRTGK--YLASLRGHVAAVYQI 420
Query: 239 AVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
A S D + + ++ + +++ + +SPDG +VA+GG
Sbjct: 421 AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 475
Score = 57.2 bits (132), Expect = 1e-07
Identities = 31/104 (29%), Positives = 53/104 (50%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPD + V S S I ++ +GK L +A+S D + + SG+ D +
Sbjct: 380 FSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
++DV KL L GHA + ++ +SPD Q + +G D ++++
Sbjct: 440 VWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
H +SV FSP G+ +A+ + D ++R L T + H H V + ++ DG KL
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLA 172
Query: 458 SVSKDKSINIYECPIPPKSAKKV 480
S K+ I +++ P + K+V
Sbjct: 173 SGCKNGQILLWD----PSTGKQV 191
Score = 37.9 bits (84), Expect = 0.078
Identities = 19/67 (28%), Positives = 37/67 (55%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + +S D + ++SGS+ + ++ V++ K L +V +SPDG+ +ASG
Sbjct: 417 VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGK 476
Query: 69 DGIINIF 75
D + I+
Sbjct: 477 DKCLRIW 483
>AB209111-1|BAD92348.1| 487|Homo sapiens Notchless gene homolog
variant protein.
Length = 487
Score = 137 bits (332), Expect = 7e-32
Identities = 100/390 (25%), Positives = 183/390 (46%), Gaps = 25/390 (6%)
Query: 44 LDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ 103
L+ + +SVA+SP GKY+ASG+ D + +D++ T +GH + S+ +SPD +
Sbjct: 112 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGK 171
Query: 104 LLLTGSDDGHMKLYDVVHANLAG-TLSGHASWVLSVAF-----SPDGKRFVSGSADRTVR 157
L +G +G + L+D G TL+GH+ W+ +++ +P+ + S S D +VR
Sbjct: 172 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 231
Query: 158 VWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSY 217
+WD + +C+ H V +++ + + S S+D+ +KVW
Sbjct: 232 IWDTTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQDR--------------TIKVWRA 276
Query: 218 ENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDM 277
+ L TL+GH V ++A+S D ++E++ +
Sbjct: 277 HDG--VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGFLQELKERALSR 334
Query: 278 WKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDT-RGKFIMSVAWSPDGRYIASGAE 336
+ +V ++ +G + ++ T I V +SPD R +AS +
Sbjct: 335 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 394
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S+ L+D GK L ++ H AV +A+S ++LL S S+D + V+++++ L L
Sbjct: 395 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 454
Query: 397 -DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
H +V +SPDGQR+A+ D +R+
Sbjct: 455 PGHADEVYAVDWSPDGQRVASGGKDKCLRI 484
Score = 105 bits (252), Expect = 3e-22
Identities = 88/400 (22%), Positives = 173/400 (43%), Gaps = 18/400 (4%)
Query: 74 IFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA 132
IF V A + +LEGH+ ++ S+ FSP + L +GS D ++ +D+ T GH
Sbjct: 99 IFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHR 158
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDS-MQCQHTFKEHNDQVWGVKFNAESNKIIS 191
WVLS+++SPDGK+ SG + + +WD + Q T H+ + G+ +
Sbjct: 159 HWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWE-------- 210
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
P Y+ + D V++W + E + L GH V + DG +
Sbjct: 211 -PLHANPECRYVASSSKDGSVRIWDTTAGRCERI--LTGHTQSVTCLRWGGDG-LLYSAS 266
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY-GIINGTVDK 310
G R +Q + + S D + + +V + G + +
Sbjct: 267 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGFLQE 326
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM-LHTIEAHAQAVRSLAFSPK 369
L R ++ + SG++ +++L+ ++ K L + H + + FSP
Sbjct: 327 -LKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD 385
Query: 370 TKLLASASNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
++++ASAS D + +++ + L + H + +S D + + + ++D +++V +
Sbjct: 386 SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 445
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ ++ H V V ++ DG ++ S KDK + I+
Sbjct: 446 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 485
Score = 101 bits (243), Expect = 4e-21
Identities = 90/363 (24%), Positives = 163/363 (44%), Gaps = 38/363 (10%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP GK++ SGS + + + + + LS+++SPDGK +ASG
Sbjct: 119 VISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCK 178
Query: 69 DGIINIFDVAQGKLV-HTLEGHAMSIRSLCF-----SPDSQLLLTGSDDGHMKLYDVVHA 122
+G I ++D + GK V TL GH+ I L + +P+ + + + S DG ++++D
Sbjct: 179 NGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAG 238
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL-DSMQCQHTFKEHNDQV---- 177
L+GH V + + DG + S S DRT++VW D + C+ T + H V
Sbjct: 239 RCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAHDGVLCR-TLQGHGHWVNTMA 296
Query: 178 ----WGVKFNAESNKIISVS-----------EDKGPSKDYIVTG-GLDNLVK-------- 213
+ ++ A SV+ +++ S+ +V G G + LV
Sbjct: 297 LSTDYALRTGAFEPAEASVNPQDLQGFLQELKERALSRYNLVRGQGPERLVSGSDDFTLF 356
Query: 214 VWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTD 273
+WS +K L + GH+ + V SPD +A G+ + ++
Sbjct: 357 LWSPAEDKKPLTR-MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGH 415
Query: 274 SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ +++I +S D + +G + V+ + + L + +V WSPDG+ +AS
Sbjct: 416 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVAS 475
Query: 334 GAE 336
G +
Sbjct: 476 GGK 478
Score = 95.9 bits (228), Expect = 3e-19
Identities = 48/142 (33%), Positives = 83/142 (58%), Gaps = 1/142 (0%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGIINIFDV 77
+ ++SGS+ + ++ K+ T + ++ V +SPD + +AS + D I ++D
Sbjct: 344 ERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDG 403
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLS 137
GK + +L GH ++ + +S DS+LL++GS D +K++DV LA L GHA V +
Sbjct: 404 RTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYA 463
Query: 138 VAFSPDGKRFVSGSADRTVRVW 159
V +SPDG+R SG D+ +R+W
Sbjct: 464 VDWSPDGQRVASGGKDKCLRIW 485
Score = 80.6 bits (190), Expect = 1e-14
Identities = 77/350 (22%), Positives = 144/350 (41%), Gaps = 23/350 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
+L GH+ V+SVAFSP GK SGS D TVR WDL + T K H V + ++ +
Sbjct: 111 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 170
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA-----VS 241
K+ S G + + +W K ++ TL GH + ++ +
Sbjct: 171 KKLAS--------------GCKNGQILLWDPSTGK-QVGRTLAGHSKWITGLSWEPLHAN 215
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
P+ +A G+ R + + + + + DG + + + V+
Sbjct: 216 PECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVW 274
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+G + + L G ++ ++A S D E + L ++ A +
Sbjct: 275 RAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGFLQELKERALSR 334
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
+L + L S S+D + +++ + L H+ V FSPD + +A+++
Sbjct: 335 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 394
Query: 420 DGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
D SI++ + L + H V + ++AD LVS S D ++ +++
Sbjct: 395 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 444
Score = 67.3 bits (157), Expect = 1e-10
Identities = 65/292 (22%), Positives = 116/292 (39%), Gaps = 21/292 (7%)
Query: 4 TGLTDVWT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TGL+ W L +P+ ++V S S G + I+ +G+ E++L + + + DG
Sbjct: 205 TGLS--WEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 261
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ S + D I ++ G L TL+GH + ++ S D L + +
Sbjct: 262 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQ 321
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD-LDSMQCQHTFKEHNDQVWGVK 181
L A ++ +R VSGS D T+ +W + + H + V
Sbjct: 322 GFLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVL 381
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
F+ +S + S S DK +K+W K L +L GH V +A S
Sbjct: 382 FSPDSRIVASASFDKS--------------IKLWDGRTGK--YLASLRGHVAAVYQIAWS 425
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
D + + ++ + +++ + +SPDG +VA+GG
Sbjct: 426 ADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 477
Score = 57.2 bits (132), Expect = 1e-07
Identities = 31/104 (29%), Positives = 53/104 (50%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPD + V S S I ++ +GK L +A+S D + + SG+ D +
Sbjct: 382 FSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 441
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
++DV KL L GHA + ++ +SPD Q + +G D ++++
Sbjct: 442 VWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 485
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
H +SV FSP G+ +A+ + D ++R L T + H H V + ++ DG KL
Sbjct: 115 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLA 174
Query: 458 SVSKDKSINIYECPIPPKSAKKV 480
S K+ I +++ P + K+V
Sbjct: 175 SGCKNGQILLWD----PSTGKQV 193
Score = 37.9 bits (84), Expect = 0.078
Identities = 19/67 (28%), Positives = 37/67 (55%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + +S D + ++SGS+ + ++ V++ K L +V +SPDG+ +ASG
Sbjct: 419 VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGK 478
Query: 69 DGIINIF 75
D + I+
Sbjct: 479 DKCLRIW 485
>BC036377-1|AAH36377.1| 415|Homo sapiens WD repeat domain 69
protein.
Length = 415
Score = 134 bits (325), Expect = 5e-31
Identities = 86/342 (25%), Positives = 154/342 (45%), Gaps = 16/342 (4%)
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L H + +VA + G F++GS DRT ++WD S + +T + H + V+ + FN
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN---- 143
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
P D I TG D K+WS E K HT GH +V ++ +P +
Sbjct: 144 ---------NPYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNPQSTLV 192
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT 307
A G+++ ++ S+++ + F+ G ++ TG V V+ G
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
Query: 308 VDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
+L I S +++ D I +G+ + L+D + GK + T+ H + F
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD 312
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVV 426
KL+A+AS DG +++ + KL+ H+ + F+P G + T ++D + R+
Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 427 LLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ + L E HT + FN G+ +++ SKD + I+
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 132 bits (319), Expect = 3e-30
Identities = 85/320 (26%), Positives = 147/320 (45%), Gaps = 17/320 (5%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYS-PDGKYIASGALDGIINIFD 76
G I+GS ++ SG++ L+ ++A++ P G IA+G+ D ++
Sbjct: 104 GSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWS 163
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V GK HT GH I L F+P S L+ TGS D KL+D+ + TL GH++ ++
Sbjct: 164 VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEII 223
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
S++F+ G R ++GS D TV VWD D+ + + H ++ FN + +
Sbjct: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--------- 274
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
I+TG +D K+W N K + TL GH+ ++ G+ IA
Sbjct: 275 -----LILTGSMDKTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKLIATASADGTA 327
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I +++ ++ KI F+P G+ + TG ++ G +VL+
Sbjct: 328 RIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHT 387
Query: 317 KFIMSVAWSPDGRYIASGAE 336
I S A++ G + +G++
Sbjct: 388 DEIFSCAFNYKGNIVITGSK 407
Score = 129 bits (311), Expect = 2e-29
Identities = 79/346 (22%), Positives = 153/346 (44%), Gaps = 18/346 (5%)
Query: 82 LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF- 140
L L+ H + + ++ + +TGS D KL+D TL GH + V ++AF
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G + +GS D+T ++W +++ +C HTF+ H ++ + FN P
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN--------------PQS 189
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
+ TG +D K+W +N E ++TL GH ++S++ + G+ I
Sbjct: 190 TLVATGSMDTTAKLWDIQNG--EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G+K+ + +++ F+ D S + TG ++ NG L I+
Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEIL 307
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDG 380
+ G+ IA+ + G+ +F + K + +E H + ++F+P+ L + S+D
Sbjct: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK 367
Query: 381 YVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+++ ++ LQ H S F+ G + T + D + R+
Sbjct: 368 TARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
Score = 117 bits (282), Expect = 8e-26
Identities = 74/334 (22%), Positives = 145/334 (43%), Gaps = 17/334 (5%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDD 111
+VA + G +G+ D ++D A G+ ++TLEGH + ++ F +P + TGS D
Sbjct: 97 NVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFD 156
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
KL+ V T GH + ++ ++F+P +GS D T ++WD+ + + +T +
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGH 231
H+ ++ + FN S D I+TG D+ V VW + + ++ L GH
Sbjct: 217 GHSAEIISLSFNT--------------SGDRIITGSFDHTVVVWDADTGR--KVNILIGH 260
Query: 232 EMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
+ S + + D I G+ + + ++ F G +AT
Sbjct: 261 CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIAT 320
Query: 292 GGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKML 351
G ++ L+ I ++++P G ++ +G+ + ++D G+ L
Sbjct: 321 ASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVY 385
+E H + S AF+ K ++ + S D ++
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 115 bits (277), Expect = 3e-25
Identities = 52/188 (27%), Positives = 98/188 (52%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
++ +L F+ G +I+GS ++++ ++G++ +L S +++ D I +G+
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D ++D GK V TL GH I CF +L+ T S DG +++
Sbjct: 281 MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK 340
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L GH + ++F+P G ++GS+D+T R+WD + QC + H D+++ FN + N
Sbjct: 341 LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGN 400
Query: 188 KIISVSED 195
+I+ S+D
Sbjct: 401 IVITGSKD 408
Score = 105 bits (253), Expect = 3e-22
Identities = 63/246 (25%), Positives = 112/246 (45%), Gaps = 16/246 (6%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
F ++ L F+P V +GS ++ +++G++ L +S++++ G
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
I +G+ D + ++D G+ V+ L GH I S F+ D L+LTGS D KL+D +
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
TL+GH +L F GK + SAD T R++ + +C + H ++ +
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
FN + N +++TG D ++W + + L LEGH + S A +
Sbjct: 353 FNPQGN--------------HLLTGSSDKTARIWDAQTG--QCLQVLEGHTDEIFSCAFN 396
Query: 242 PDGETI 247
G +
Sbjct: 397 YKGNIV 402
Score = 94.3 bits (224), Expect = 9e-19
Identities = 64/268 (23%), Positives = 123/268 (45%), Gaps = 4/268 (1%)
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS-PDGETIAXXXXXXXXXXXXXX 262
+TG D K+W + E L+TLEGH V ++A + P G+ IA
Sbjct: 108 ITGSYDRTCKLWDTASG--EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE 165
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ + ++++ + F+P + VATG ++ I NG L I+S+
Sbjct: 166 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISL 225
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+++ G I +G+ +V ++D G+ ++ + H + S +F+ L+ + S D
Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285
Query: 383 NVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT 441
+++ + L H + CF G+ +AT++ADG+ R+ + + E H
Sbjct: 286 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHE 345
Query: 442 HIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + FN G+ L++ S DK+ I++
Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 81.4 bits (192), Expect = 6e-15
Identities = 45/152 (29%), Positives = 69/152 (45%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
++ + F+ D +++GS ++ +GK L L + GK IA+ +
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
DG IF A K + LEGH I + F+P LLTGS D +++D
Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L GH + S AF+ G ++GS D T R+W
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 61.3 bits (142), Expect = 7e-09
Identities = 36/162 (22%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAF-SP 368
KVL + +VA + G +G+ + L+D + G+ L+T+E H V ++AF +P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
+A+ S D ++++E+ + H V + F+P +AT + D + ++
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ ++T H+ + + FN G ++++ S D ++ +++
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
>AK097409-1|BAC05039.1| 415|Homo sapiens protein ( Homo sapiens
cDNA FLJ40090 fis, clone TESTI2003596, weakly similar to
VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1. ).
Length = 415
Score = 134 bits (325), Expect = 5e-31
Identities = 86/342 (25%), Positives = 154/342 (45%), Gaps = 16/342 (4%)
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L H + +VA + G F++GS DRT ++WD S + +T + H + V+ + FN
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN---- 143
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
P D I TG D K+WS E K HT GH +V ++ +P +
Sbjct: 144 ---------NPYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNPQSTLV 192
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT 307
A G+++ ++ S+++ + F+ G ++ TG V V+ G
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
Query: 308 VDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
+L I S +++ D I +G+ + L+D + GK + T+ H + F
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD 312
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVV 426
KL+A+AS DG +++ + KL+ H+ + F+P G + T ++D + R+
Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 427 LLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ + L E HT + FN G+ +++ SKD + I+
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 132 bits (319), Expect = 3e-30
Identities = 85/320 (26%), Positives = 147/320 (45%), Gaps = 17/320 (5%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYS-PDGKYIASGALDGIINIFD 76
G I+GS ++ SG++ L+ ++A++ P G IA+G+ D ++
Sbjct: 104 GSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWS 163
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V GK HT GH I L F+P S L+ TGS D KL+D+ + TL GH++ ++
Sbjct: 164 VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEII 223
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
S++F+ G R ++GS D TV VWD D+ + + H ++ FN + +
Sbjct: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--------- 274
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
I+TG +D K+W N K + TL GH+ ++ G+ IA
Sbjct: 275 -----LILTGSMDKTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKLIATASADGTA 327
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I +++ ++ KI F+P G+ + TG ++ G +VL+
Sbjct: 328 RIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHT 387
Query: 317 KFIMSVAWSPDGRYIASGAE 336
I S A++ G + +G++
Sbjct: 388 DEIFSCAFNYKGNIVITGSK 407
Score = 129 bits (311), Expect = 2e-29
Identities = 79/346 (22%), Positives = 153/346 (44%), Gaps = 18/346 (5%)
Query: 82 LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF- 140
L L+ H + + ++ + +TGS D KL+D TL GH + V ++AF
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G + +GS D+T ++W +++ +C HTF+ H ++ + FN P
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN--------------PQS 189
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
+ TG +D K+W +N E ++TL GH ++S++ + G+ I
Sbjct: 190 TLVATGSMDTTAKLWDIQNG--EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G+K+ + +++ F+ D S + TG ++ NG L I+
Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEIL 307
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDG 380
+ G+ IA+ + G+ +F + K + +E H + ++F+P+ L + S+D
Sbjct: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK 367
Query: 381 YVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+++ ++ LQ H S F+ G + T + D + R+
Sbjct: 368 TARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
Score = 117 bits (282), Expect = 8e-26
Identities = 74/334 (22%), Positives = 145/334 (43%), Gaps = 17/334 (5%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDD 111
+VA + G +G+ D ++D A G+ ++TLEGH + ++ F +P + TGS D
Sbjct: 97 NVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFD 156
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
KL+ V T GH + ++ ++F+P +GS D T ++WD+ + + +T +
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGH 231
H+ ++ + FN S D I+TG D+ V VW + + ++ L GH
Sbjct: 217 GHSAEIISLSFNT--------------SGDRIITGSFDHTVVVWDADTGR--KVNILIGH 260
Query: 232 EMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
+ S + + D I G+ + + ++ F G +AT
Sbjct: 261 CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIAT 320
Query: 292 GGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKML 351
G ++ L+ I ++++P G ++ +G+ + ++D G+ L
Sbjct: 321 ASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVY 385
+E H + S AF+ K ++ + S D ++
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 115 bits (277), Expect = 3e-25
Identities = 52/188 (27%), Positives = 98/188 (52%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
++ +L F+ G +I+GS ++++ ++G++ +L S +++ D I +G+
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D ++D GK V TL GH I CF +L+ T S DG +++
Sbjct: 281 MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK 340
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L GH + ++F+P G ++GS+D+T R+WD + QC + H D+++ FN + N
Sbjct: 341 LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGN 400
Query: 188 KIISVSED 195
+I+ S+D
Sbjct: 401 IVITGSKD 408
Score = 105 bits (253), Expect = 3e-22
Identities = 63/246 (25%), Positives = 112/246 (45%), Gaps = 16/246 (6%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
F ++ L F+P V +GS ++ +++G++ L +S++++ G
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
I +G+ D + ++D G+ V+ L GH I S F+ D L+LTGS D KL+D +
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
TL+GH +L F GK + SAD T R++ + +C + H ++ +
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
FN + N +++TG D ++W + + L LEGH + S A +
Sbjct: 353 FNPQGN--------------HLLTGSSDKTARIWDAQTG--QCLQVLEGHTDEIFSCAFN 396
Query: 242 PDGETI 247
G +
Sbjct: 397 YKGNIV 402
Score = 94.3 bits (224), Expect = 9e-19
Identities = 64/268 (23%), Positives = 123/268 (45%), Gaps = 4/268 (1%)
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS-PDGETIAXXXXXXXXXXXXXX 262
+TG D K+W + E L+TLEGH V ++A + P G+ IA
Sbjct: 108 ITGSYDRTCKLWDTASG--EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE 165
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ + ++++ + F+P + VATG ++ I NG L I+S+
Sbjct: 166 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISL 225
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+++ G I +G+ +V ++D G+ ++ + H + S +F+ L+ + S D
Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285
Query: 383 NVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT 441
+++ + L H + CF G+ +AT++ADG+ R+ + + E H
Sbjct: 286 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHE 345
Query: 442 HIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + FN G+ L++ S DK+ I++
Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 81.4 bits (192), Expect = 6e-15
Identities = 45/152 (29%), Positives = 69/152 (45%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
++ + F+ D +++GS ++ +GK L L + GK IA+ +
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
DG IF A K + LEGH I + F+P LLTGS D +++D
Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L GH + S AF+ G ++GS D T R+W
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 61.3 bits (142), Expect = 7e-09
Identities = 36/162 (22%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAF-SP 368
KVL + +VA + G +G+ + L+D + G+ L+T+E H V ++AF +P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
+A+ S D ++++E+ + H V + F+P +AT + D + ++
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ ++T H+ + + FN G ++++ S D ++ +++
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
>AC073065-2|AAX93215.1| 415|Homo sapiens unknown protein.
Length = 415
Score = 134 bits (325), Expect = 5e-31
Identities = 86/342 (25%), Positives = 154/342 (45%), Gaps = 16/342 (4%)
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L H + +VA + G F++GS DRT ++WD S + +T + H + V+ + FN
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN---- 143
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
P D I TG D K+WS E K HT GH +V ++ +P +
Sbjct: 144 ---------NPYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNPQSTLV 192
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT 307
A G+++ ++ S+++ + F+ G ++ TG V V+ G
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
Query: 308 VDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
+L I S +++ D I +G+ + L+D + GK + T+ H + F
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD 312
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVV 426
KL+A+AS DG +++ + KL+ H+ + F+P G + T ++D + R+
Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 427 LLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ + L E HT + FN G+ +++ SKD + I+
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 132 bits (319), Expect = 3e-30
Identities = 85/320 (26%), Positives = 147/320 (45%), Gaps = 17/320 (5%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYS-PDGKYIASGALDGIINIFD 76
G I+GS ++ SG++ L+ ++A++ P G IA+G+ D ++
Sbjct: 104 GSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWS 163
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V GK HT GH I L F+P S L+ TGS D KL+D+ + TL GH++ ++
Sbjct: 164 VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEII 223
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
S++F+ G R ++GS D TV VWD D+ + + H ++ FN + +
Sbjct: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--------- 274
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
I+TG +D K+W N K + TL GH+ ++ G+ IA
Sbjct: 275 -----LILTGSMDKTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKLIATASADGTA 327
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I +++ ++ KI F+P G+ + TG ++ G +VL+
Sbjct: 328 RIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHT 387
Query: 317 KFIMSVAWSPDGRYIASGAE 336
I S A++ G + +G++
Sbjct: 388 DEIFSCAFNYKGNIVITGSK 407
Score = 129 bits (311), Expect = 2e-29
Identities = 79/346 (22%), Positives = 153/346 (44%), Gaps = 18/346 (5%)
Query: 82 LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF- 140
L L+ H + + ++ + +TGS D KL+D TL GH + V ++AF
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G + +GS D+T ++W +++ +C HTF+ H ++ + FN P
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN--------------PQS 189
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
+ TG +D K+W +N E ++TL GH ++S++ + G+ I
Sbjct: 190 TLVATGSMDTTAKLWDIQNG--EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G+K+ + +++ F+ D S + TG ++ NG L I+
Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEIL 307
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDG 380
+ G+ IA+ + G+ +F + K + +E H + ++F+P+ L + S+D
Sbjct: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK 367
Query: 381 YVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+++ ++ LQ H S F+ G + T + D + R+
Sbjct: 368 TARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
Score = 117 bits (282), Expect = 8e-26
Identities = 74/334 (22%), Positives = 145/334 (43%), Gaps = 17/334 (5%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDD 111
+VA + G +G+ D ++D A G+ ++TLEGH + ++ F +P + TGS D
Sbjct: 97 NVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFD 156
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
KL+ V T GH + ++ ++F+P +GS D T ++WD+ + + +T +
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGH 231
H+ ++ + FN S D I+TG D+ V VW + + ++ L GH
Sbjct: 217 GHSAEIISLSFNT--------------SGDRIITGSFDHTVVVWDADTGR--KVNILIGH 260
Query: 232 EMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
+ S + + D I G+ + + ++ F G +AT
Sbjct: 261 CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIAT 320
Query: 292 GGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKML 351
G ++ L+ I ++++P G ++ +G+ + ++D G+ L
Sbjct: 321 ASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVY 385
+E H + S AF+ K ++ + S D ++
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 115 bits (277), Expect = 3e-25
Identities = 52/188 (27%), Positives = 98/188 (52%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
++ +L F+ G +I+GS ++++ ++G++ +L S +++ D I +G+
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D ++D GK V TL GH I CF +L+ T S DG +++
Sbjct: 281 MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK 340
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L GH + ++F+P G ++GS+D+T R+WD + QC + H D+++ FN + N
Sbjct: 341 LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGN 400
Query: 188 KIISVSED 195
+I+ S+D
Sbjct: 401 IVITGSKD 408
Score = 105 bits (253), Expect = 3e-22
Identities = 63/246 (25%), Positives = 112/246 (45%), Gaps = 16/246 (6%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
F ++ L F+P V +GS ++ +++G++ L +S++++ G
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
I +G+ D + ++D G+ V+ L GH I S F+ D L+LTGS D KL+D +
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
TL+GH +L F GK + SAD T R++ + +C + H ++ +
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
FN + N +++TG D ++W + + L LEGH + S A +
Sbjct: 353 FNPQGN--------------HLLTGSSDKTARIWDAQTG--QCLQVLEGHTDEIFSCAFN 396
Query: 242 PDGETI 247
G +
Sbjct: 397 YKGNIV 402
Score = 94.3 bits (224), Expect = 9e-19
Identities = 64/268 (23%), Positives = 123/268 (45%), Gaps = 4/268 (1%)
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS-PDGETIAXXXXXXXXXXXXXX 262
+TG D K+W + E L+TLEGH V ++A + P G+ IA
Sbjct: 108 ITGSYDRTCKLWDTASG--EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE 165
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ + ++++ + F+P + VATG ++ I NG L I+S+
Sbjct: 166 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISL 225
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+++ G I +G+ +V ++D G+ ++ + H + S +F+ L+ + S D
Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285
Query: 383 NVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT 441
+++ + L H + CF G+ +AT++ADG+ R+ + + E H
Sbjct: 286 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHE 345
Query: 442 HIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + FN G+ L++ S DK+ I++
Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 81.4 bits (192), Expect = 6e-15
Identities = 45/152 (29%), Positives = 69/152 (45%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
++ + F+ D +++GS ++ +GK L L + GK IA+ +
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
DG IF A K + LEGH I + F+P LLTGS D +++D
Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L GH + S AF+ G ++GS D T R+W
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 61.3 bits (142), Expect = 7e-09
Identities = 36/162 (22%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAF-SP 368
KVL + +VA + G +G+ + L+D + G+ L+T+E H V ++AF +P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
+A+ S D ++++E+ + H V + F+P +AT + D + ++
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ ++T H+ + + FN G ++++ S D ++ +++
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
>AK098821-1|BAC05425.1| 415|Homo sapiens protein ( Homo sapiens
cDNA FLJ25955 fis, clone TST03904. ).
Length = 415
Score = 134 bits (324), Expect = 7e-31
Identities = 86/323 (26%), Positives = 149/323 (46%), Gaps = 17/323 (5%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYS-PDGKYIASGALDGIINIFD 76
G I+GS ++ SG++ L+ ++A++ P G IA+G+ D ++
Sbjct: 104 GSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWS 163
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V GK HT GH I L F+P S L+ TGS D KL+D+ + TL GH++ ++
Sbjct: 164 VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEII 223
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
S++F+ G R ++GS D TV VWD D+ + + H ++ FN + +
Sbjct: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--------- 274
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
I+TG +D K+W N K + TL GH+ ++ G+ IA
Sbjct: 275 -----LILTGSMDKTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKLIATASADGTA 327
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I +++ ++ KI F+P G+ + TG ++ G +VL+
Sbjct: 328 RIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHT 387
Query: 317 KFIMSVAWSPDGRYIASGAEGGS 339
I S A++ G + +G++G +
Sbjct: 388 DEIFSCAFNYKGNIVITGSKGNT 410
Score = 131 bits (317), Expect = 5e-30
Identities = 85/342 (24%), Positives = 153/342 (44%), Gaps = 16/342 (4%)
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L H + +VA + G F++GS DRT ++WD S + +T + H + V+ + FN
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFN---- 143
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
P D I TG D K+WS E K HT GH +V ++ +P +
Sbjct: 144 ---------NPYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNPQSTLV 192
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT 307
A G+++ ++ S+++ + F+ G ++ TG V V+ G
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
Query: 308 VDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
+L I S +++ D I +G+ + L+D + GK + T+ H + F
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD 312
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVV 426
KL+A+AS DG +++ + KL+ H+ + F+P G + T ++D + R+
Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 427 LLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ + L E HT + FN G+ +++ SK + I+
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKGNTCRIW 414
Score = 125 bits (302), Expect = 3e-28
Identities = 78/346 (22%), Positives = 152/346 (43%), Gaps = 18/346 (5%)
Query: 82 LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF- 140
L L+ H + + ++ + +TGS D KL+D TL GH + V ++AF
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFN 143
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G + +GS D+T ++W +++ +C HTF+ H ++ + FN P
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN--------------PQS 189
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
+ TG +D K+W +N E ++TL GH ++S++ + G+ I
Sbjct: 190 TLVATGSMDTTAKLWDIQNG--EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G+K+ + +++ F+ D S + TG ++ NG L I+
Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEIL 307
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDG 380
+ G+ IA+ + G+ +F + K + +E H + ++F+P+ L + S+D
Sbjct: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK 367
Query: 381 YVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+++ ++ LQ H S F+ G + T + + R+
Sbjct: 368 TARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKGNTCRI 413
Score = 113 bits (273), Expect = 1e-24
Identities = 73/334 (21%), Positives = 144/334 (43%), Gaps = 17/334 (5%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDD 111
+VA + G +G+ D ++D A G+ ++TLEGH + ++ F +P + TGS D
Sbjct: 97 NVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFD 156
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
KL+ V T GH + ++ ++F+P +GS D T ++WD+ + + +T +
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGH 231
H+ ++ + FN S D I+TG D+ V VW + + ++ L GH
Sbjct: 217 GHSAEIISLSFNT--------------SGDRIITGSFDHTVVVWDADTGR--KVNILIGH 260
Query: 232 EMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
+ S + + D I G+ + + ++ F G +AT
Sbjct: 261 CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIAT 320
Query: 292 GGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKML 351
G ++ L+ I ++++P G ++ +G+ + ++D G+ L
Sbjct: 321 ASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVY 385
+E H + S AF+ K ++ + S ++
Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKGNTCRIW 414
Score = 113 bits (271), Expect = 2e-24
Identities = 51/187 (27%), Positives = 97/187 (51%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
++ +L F+ G +I+GS ++++ ++G++ +L S +++ D I +G+
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D ++D GK V TL GH I CF +L+ T S DG +++
Sbjct: 281 MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK 340
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L GH + ++F+P G ++GS+D+T R+WD + QC + H D+++ FN + N
Sbjct: 341 LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGN 400
Query: 188 KIISVSE 194
+I+ S+
Sbjct: 401 IVITGSK 407
Score = 105 bits (253), Expect = 3e-22
Identities = 63/246 (25%), Positives = 112/246 (45%), Gaps = 16/246 (6%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
F ++ L F+P V +GS ++ +++G++ L +S++++ G
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
I +G+ D + ++D G+ V+ L GH I S F+ D L+LTGS D KL+D +
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
TL+GH +L F GK + SAD T R++ + +C + H ++ +
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
FN + N +++TG D ++W + + L LEGH + S A +
Sbjct: 353 FNPQGN--------------HLLTGSSDKTARIWDAQTG--QCLQVLEGHTDEIFSCAFN 396
Query: 242 PDGETI 247
G +
Sbjct: 397 YKGNIV 402
Score = 94.3 bits (224), Expect = 9e-19
Identities = 64/268 (23%), Positives = 123/268 (45%), Gaps = 4/268 (1%)
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS-PDGETIAXXXXXXXXXXXXXX 262
+TG D K+W + E L+TLEGH V ++A + P G+ IA
Sbjct: 108 ITGSYDRTCKLWDSASG--EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE 165
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ + ++++ + F+P + VATG ++ I NG L I+S+
Sbjct: 166 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISL 225
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+++ G I +G+ +V ++D G+ ++ + H + S +F+ L+ + S D
Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285
Query: 383 NVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT 441
+++ + L H + CF G+ +AT++ADG+ R+ + + E H
Sbjct: 286 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHE 345
Query: 442 HIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + FN G+ L++ S DK+ I++
Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 78.6 bits (185), Expect = 5e-14
Identities = 44/152 (28%), Positives = 68/152 (44%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
++ + F+ D +++GS ++ +GK L L + GK IA+ +
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
DG IF A K + LEGH I + F+P LLTGS D +++D
Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L GH + S AF+ G ++GS T R+W
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITGSKGNTCRIW 414
Score = 60.5 bits (140), Expect = 1e-08
Identities = 36/162 (22%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAF-SP 368
KVL + +VA + G +G+ + L+D + G+ L+T+E H V ++AF +P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNNP 145
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
+A+ S D ++++E+ + H V + F+P +AT + D + ++
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ ++T H+ + + FN G ++++ S D ++ +++
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
>BX649632-1|CAI18774.1| 334|Homo sapiens WD repeat domain 5
protein.
Length = 334
Score = 126 bits (304), Expect = 2e-28
Identities = 84/291 (28%), Positives = 137/291 (47%), Gaps = 20/291 (6%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K SV +SP+G+++AS + D +I I+ GK T+ GH + I + +S DS LL++
Sbjct: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
SDD +K++DV TL GH+++V F+P VSGS D +VR+WD+ + +C
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
T H+D V V FN + + I+S S D L ++W + + L TL
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSS--------------YDGLCRIWDTASG--QCLKTL 209
Query: 229 EGHEMPVVS-VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV--FSPD 285
+ P VS V SP+G+ I G+ ++ ++ + I FS
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 286 GSQ-VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGA 335
G + + +G V ++ + + + L ++S A P IAS A
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Score = 124 bits (298), Expect = 9e-28
Identities = 84/310 (27%), Positives = 143/310 (46%), Gaps = 22/310 (7%)
Query: 82 LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFS 141
L TL GH ++ S+ FSP+ + L + S D +K++ T+SGH + VA+S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 142 PDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKD 201
D VS S D+T+++WD+ S +C T K H++ V+ FN +SN I+S
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS---------- 146
Query: 202 YIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
G D V++W + K L TL H PV +V + DG I
Sbjct: 147 ----GSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 262 XXGQKIRE-IQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKF 318
GQ ++ I D+ + + FSP+G + + ++ G K K+
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260
Query: 319 IMSVAWS-PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
+ +S G++I SG+E VY++++ +++ ++ H V S A P ++ASA+
Sbjct: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Query: 378 --NDGYVNVY 385
ND + ++
Sbjct: 321 LENDKTIKLW 330
Score = 114 bits (274), Expect = 7e-25
Identities = 75/225 (33%), Positives = 112/225 (49%), Gaps = 17/225 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP+G+ + S S I I+G GK E+ + VA+S D + S +
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + I+DV+ GK + TL+GH+ + F+P S L+++GS D ++++DV TL
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT-FKEHNDQVWGVKFNAESN 187
H+ V +V F+ DG VS S D R+WD S QC T + N V VKF+
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS---- 223
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
P+ YI+ LDN +K+W Y K L T GH+
Sbjct: 224 ----------PNGKYILAATLDNTLKLWDYSKGK--CLKTYTGHK 256
Score = 87.0 bits (206), Expect = 1e-16
Identities = 63/250 (25%), Positives = 114/250 (45%), Gaps = 5/250 (2%)
Query: 224 LLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFS 283
L TL GH V SV SP+GE +A G+ + I + + +S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 284 PDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
D + + + + ++ + +G K L ++ ++P I SG+ SV ++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 344 DVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKLDHKCWA 402
DV GK L T+ AH+ V ++ F+ L+ S+S DG +++ S L+ +D
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 403 VS-VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH--IVCGVQFNADGSK-LVS 458
VS V FSP+G+ + + D ++++ + + L T+ H + F+ G K +VS
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 459 VSKDKSINIY 468
S+D + I+
Sbjct: 277 GSEDNLVYIW 286
Score = 80.6 bits (190), Expect = 1e-14
Identities = 60/299 (20%), Positives = 130/299 (43%), Gaps = 9/299 (3%)
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ +KF + S P+ +++ + D L+K+W + K E T+ GH++ +
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISD 92
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
VA S D + G+ ++ ++ S+ ++ F+P + + +G
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152
Query: 298 VTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHT-IEA 356
V ++ + G K L + +V ++ DG I S + G ++D + G+ L T I+
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHK--CWAVSVCFSPDGQR 413
V + FSP K + +A+ D + +++ + L+ HK + + FS G +
Sbjct: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272
Query: 414 MATSAA-DGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVS--VSKDKSINIYE 469
S + D + + L+ ++ + HT +V + + + S + DK+I +++
Sbjct: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
>BC001635-1|AAH01635.1| 334|Homo sapiens WD repeat domain 5
protein.
Length = 334
Score = 126 bits (304), Expect = 2e-28
Identities = 84/291 (28%), Positives = 137/291 (47%), Gaps = 20/291 (6%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K SV +SP+G+++AS + D +I I+ GK T+ GH + I + +S DS LL++
Sbjct: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
SDD +K++DV TL GH+++V F+P VSGS D +VR+WD+ + +C
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
T H+D V V FN + + I+S S D L ++W + + L TL
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSS--------------YDGLCRIWDTASG--QCLKTL 209
Query: 229 EGHEMPVVS-VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV--FSPD 285
+ P VS V SP+G+ I G+ ++ ++ + I FS
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 286 GSQ-VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGA 335
G + + +G V ++ + + + L ++S A P IAS A
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Score = 124 bits (298), Expect = 9e-28
Identities = 84/310 (27%), Positives = 143/310 (46%), Gaps = 22/310 (7%)
Query: 82 LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFS 141
L TL GH ++ S+ FSP+ + L + S D +K++ T+SGH + VA+S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 142 PDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKD 201
D VS S D+T+++WD+ S +C T K H++ V+ FN +SN I+S
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS---------- 146
Query: 202 YIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
G D V++W + K L TL H PV +V + DG I
Sbjct: 147 ----GSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 262 XXGQKIRE-IQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKF 318
GQ ++ I D+ + + FSP+G + + ++ G K K+
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260
Query: 319 IMSVAWS-PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
+ +S G++I SG+E VY++++ +++ ++ H V S A P ++ASA+
Sbjct: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Query: 378 --NDGYVNVY 385
ND + ++
Sbjct: 321 LENDKTIKLW 330
Score = 114 bits (274), Expect = 7e-25
Identities = 75/225 (33%), Positives = 112/225 (49%), Gaps = 17/225 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP+G+ + S S I I+G GK E+ + VA+S D + S +
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + I+DV+ GK + TL+GH+ + F+P S L+++GS D ++++DV TL
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT-FKEHNDQVWGVKFNAESN 187
H+ V +V F+ DG VS S D R+WD S QC T + N V VKF+
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS---- 223
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
P+ YI+ LDN +K+W Y K L T GH+
Sbjct: 224 ----------PNGKYILAATLDNTLKLWDYSKGK--CLKTYTGHK 256
Score = 87.0 bits (206), Expect = 1e-16
Identities = 63/250 (25%), Positives = 114/250 (45%), Gaps = 5/250 (2%)
Query: 224 LLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFS 283
L TL GH V SV SP+GE +A G+ + I + + +S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 284 PDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
D + + + + ++ + +G K L ++ ++P I SG+ SV ++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 344 DVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKLDHKCWA 402
DV GK L T+ AH+ V ++ F+ L+ S+S DG +++ S L+ +D
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 403 VS-VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH--IVCGVQFNADGSK-LVS 458
VS V FSP+G+ + + D ++++ + + L T+ H + F+ G K +VS
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 459 VSKDKSINIY 468
S+D + I+
Sbjct: 277 GSEDNLVYIW 286
Score = 80.6 bits (190), Expect = 1e-14
Identities = 60/299 (20%), Positives = 130/299 (43%), Gaps = 9/299 (3%)
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ +KF + S P+ +++ + D L+K+W + K E T+ GH++ +
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISD 92
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
VA S D + G+ ++ ++ S+ ++ F+P + + +G
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152
Query: 298 VTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHT-IEA 356
V ++ + G K L + +V ++ DG I S + G ++D + G+ L T I+
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHK--CWAVSVCFSPDGQR 413
V + FSP K + +A+ D + +++ + L+ HK + + FS G +
Sbjct: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272
Query: 414 MATSAA-DGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVS--VSKDKSINIYE 469
S + D + + L+ ++ + HT +V + + + S + DK+I +++
Sbjct: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
>AK000552-1|BAA91248.1| 334|Homo sapiens protein ( Homo sapiens
cDNA FLJ20545 fis, clone KAT11476. ).
Length = 334
Score = 126 bits (304), Expect = 2e-28
Identities = 84/291 (28%), Positives = 137/291 (47%), Gaps = 20/291 (6%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K SV +SP+G+++AS + D +I I+ GK T+ GH + I + +S DS LL++
Sbjct: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
SDD +K++DV TL GH+++V F+P VSGS D +VR+WD+ + +C
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
T H+D V V FN + + I+S S D L ++W + + L TL
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSS--------------YDGLCRIWDTASG--QCLKTL 209
Query: 229 EGHEMPVVS-VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV--FSPD 285
+ P VS V SP+G+ I G+ ++ ++ + I FS
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 286 GSQ-VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGA 335
G + + +G V ++ + + + L ++S A P IAS A
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Score = 124 bits (298), Expect = 9e-28
Identities = 84/310 (27%), Positives = 143/310 (46%), Gaps = 22/310 (7%)
Query: 82 LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFS 141
L TL GH ++ S+ FSP+ + L + S D +K++ T+SGH + VA+S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 142 PDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKD 201
D VS S D+T+++WD+ S +C T K H++ V+ FN +SN I+S
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS---------- 146
Query: 202 YIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
G D V++W + K L TL H PV +V + DG I
Sbjct: 147 ----GSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 262 XXGQKIRE-IQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKF 318
GQ ++ I D+ + + FSP+G + + ++ G K K+
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260
Query: 319 IMSVAWS-PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
+ +S G++I SG+E VY++++ +++ ++ H V S A P ++ASA+
Sbjct: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Query: 378 --NDGYVNVY 385
ND + ++
Sbjct: 321 LENDKTIKLW 330
Score = 114 bits (274), Expect = 7e-25
Identities = 75/225 (33%), Positives = 112/225 (49%), Gaps = 17/225 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP+G+ + S S I I+G GK E+ + VA+S D + S +
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + I+DV+ GK + TL+GH+ + F+P S L+++GS D ++++DV TL
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT-FKEHNDQVWGVKFNAESN 187
H+ V +V F+ DG VS S D R+WD S QC T + N V VKF+
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS---- 223
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
P+ YI+ LDN +K+W Y K L T GH+
Sbjct: 224 ----------PNGKYILAATLDNTLKLWDYSKGK--CLKTYTGHK 256
Score = 87.0 bits (206), Expect = 1e-16
Identities = 63/250 (25%), Positives = 114/250 (45%), Gaps = 5/250 (2%)
Query: 224 LLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFS 283
L TL GH V SV SP+GE +A G+ + I + + +S
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 284 PDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
D + + + + ++ + +G K L ++ ++P I SG+ SV ++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 344 DVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKLDHKCWA 402
DV GK L T+ AH+ V ++ F+ L+ S+S DG +++ S L+ +D
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
Query: 403 VS-VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH--IVCGVQFNADGSK-LVS 458
VS V FSP+G+ + + D ++++ + + L T+ H + F+ G K +VS
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 459 VSKDKSINIY 468
S+D + I+
Sbjct: 277 GSEDNLVYIW 286
Score = 80.6 bits (190), Expect = 1e-14
Identities = 60/299 (20%), Positives = 130/299 (43%), Gaps = 9/299 (3%)
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ +KF + S P+ +++ + D L+K+W + K E T+ GH++ +
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISD 92
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
VA S D + G+ ++ ++ S+ ++ F+P + + +G
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152
Query: 298 VTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHT-IEA 356
V ++ + G K L + +V ++ DG I S + G ++D + G+ L T I+
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHK--CWAVSVCFSPDGQR 413
V + FSP K + +A+ D + +++ + L+ HK + + FS G +
Sbjct: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272
Query: 414 MATSAA-DGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVS--VSKDKSINIYE 469
S + D + + L+ ++ + HT +V + + + S + DK+I +++
Sbjct: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
>AJ011376-1|CAB66159.1| 362|Homo sapiens hypothetical protein
protein.
Length = 362
Score = 126 bits (304), Expect = 2e-28
Identities = 84/291 (28%), Positives = 137/291 (47%), Gaps = 20/291 (6%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K SV +SP+G+++AS + D +I I+ GK T+ GH + I + +S DS LL++
Sbjct: 74 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 133
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
SDD +K++DV TL GH+++V F+P VSGS D +VR+WD+ + +C
Sbjct: 134 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 193
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
T H+D V V FN + + I+S S D L ++W + + L TL
Sbjct: 194 TLPAHSDPVSAVHFNRDGSLIVSSS--------------YDGLCRIWDTASG--QCLKTL 237
Query: 229 EGHEMPVVS-VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV--FSPD 285
+ P VS V SP+G+ I G+ ++ ++ + I FS
Sbjct: 238 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 297
Query: 286 GSQ-VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGA 335
G + + +G V ++ + + + L ++S A P IAS A
Sbjct: 298 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 348
Score = 124 bits (298), Expect = 9e-28
Identities = 84/310 (27%), Positives = 143/310 (46%), Gaps = 22/310 (7%)
Query: 82 LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFS 141
L TL GH ++ S+ FSP+ + L + S D +K++ T+SGH + VA+S
Sbjct: 65 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 124
Query: 142 PDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKD 201
D VS S D+T+++WD+ S +C T K H++ V+ FN +SN I+S
Sbjct: 125 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS---------- 174
Query: 202 YIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
G D V++W + K L TL H PV +V + DG I
Sbjct: 175 ----GSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 228
Query: 262 XXGQKIRE-IQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKF 318
GQ ++ I D+ + + FSP+G + + ++ G K K+
Sbjct: 229 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 288
Query: 319 IMSVAWS-PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
+ +S G++I SG+E VY++++ +++ ++ H V S A P ++ASA+
Sbjct: 289 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 348
Query: 378 --NDGYVNVY 385
ND + ++
Sbjct: 349 LENDKTIKLW 358
Score = 114 bits (274), Expect = 7e-25
Identities = 75/225 (33%), Positives = 112/225 (49%), Gaps = 17/225 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP+G+ + S S I I+G GK E+ + VA+S D + S +
Sbjct: 76 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 135
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + I+DV+ GK + TL+GH+ + F+P S L+++GS D ++++DV TL
Sbjct: 136 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 195
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT-FKEHNDQVWGVKFNAESN 187
H+ V +V F+ DG VS S D R+WD S QC T + N V VKF+
Sbjct: 196 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS---- 251
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
P+ YI+ LDN +K+W Y K L T GH+
Sbjct: 252 ----------PNGKYILAATLDNTLKLWDYSKGK--CLKTYTGHK 284
Score = 87.0 bits (206), Expect = 1e-16
Identities = 63/250 (25%), Positives = 114/250 (45%), Gaps = 5/250 (2%)
Query: 224 LLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFS 283
L TL GH V SV SP+GE +A G+ + I + + +S
Sbjct: 65 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 124
Query: 284 PDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
D + + + + ++ + +G K L ++ ++P I SG+ SV ++
Sbjct: 125 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 184
Query: 344 DVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKLDHKCWA 402
DV GK L T+ AH+ V ++ F+ L+ S+S DG +++ S L+ +D
Sbjct: 185 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 244
Query: 403 VS-VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH--IVCGVQFNADGSK-LVS 458
VS V FSP+G+ + + D ++++ + + L T+ H + F+ G K +VS
Sbjct: 245 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 304
Query: 459 VSKDKSINIY 468
S+D + I+
Sbjct: 305 GSEDNLVYIW 314
Score = 80.6 bits (190), Expect = 1e-14
Identities = 60/299 (20%), Positives = 130/299 (43%), Gaps = 9/299 (3%)
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ +KF + S P+ +++ + D L+K+W + K E T+ GH++ +
Sbjct: 63 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISD 120
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
VA S D + G+ ++ ++ S+ ++ F+P + + +G
Sbjct: 121 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 180
Query: 298 VTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHT-IEA 356
V ++ + G K L + +V ++ DG I S + G ++D + G+ L T I+
Sbjct: 181 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 240
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHK--CWAVSVCFSPDGQR 413
V + FSP K + +A+ D + +++ + L+ HK + + FS G +
Sbjct: 241 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 300
Query: 414 MATSAA-DGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVS--VSKDKSINIYE 469
S + D + + L+ ++ + HT +V + + + S + DK+I +++
Sbjct: 301 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 359
>AK002149-1|BAA92110.1| 330|Homo sapiens protein ( Homo sapiens
cDNA FLJ11287 fis, clone PLACE1009596, weakly similar to
VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1. ).
Length = 330
Score = 122 bits (294), Expect = 3e-27
Identities = 83/287 (28%), Positives = 134/287 (46%), Gaps = 20/287 (6%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
SV +SP+G+++AS + D +I I+ GK TL GH + I + +S DS L++ SDD
Sbjct: 46 SVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDK 105
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+KL+DV TL GH+++V F+P +SGS D TV++W++ + +C T
Sbjct: 106 TLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSA 165
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H+D V V FN S IV+G D L ++W + + L TL +
Sbjct: 166 HSDPVSAVHFNC--------------SGSLIVSGSYDGLCRIWDAASG--QCLKTLVDDD 209
Query: 233 MPVVS-VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV--FSPDGSQ- 288
P VS V SP+G+ I G+ ++ ++ + I FS G +
Sbjct: 210 NPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGQKNEKYCIFANFSVTGGKW 269
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGA 335
+ +G V ++ + + + L ++S A P IAS A
Sbjct: 270 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
Score = 119 bits (286), Expect = 3e-26
Identities = 86/307 (28%), Positives = 139/307 (45%), Gaps = 22/307 (7%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH ++ S+ FSP+ + L + S D + ++ TL GH + VA+S D
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
R VS S D+T+++WD+ S +C T K H++ V+ FN SN IIS
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS------------- 142
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
G D VK+W + K L TL H PV +V + G I G
Sbjct: 143 -GSFDETVKIWEVKTGKC--LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASG 199
Query: 265 QKIREIQTDSSDMWKIV-FSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKFIMS 321
Q ++ + D + V FSP+G + T + ++ G K K+ +
Sbjct: 200 QCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGQKNEKYCIF 259
Query: 322 VAWS-PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS--N 378
+S G++I SG+E VY++++ +++ ++ H V S A P L+ASA+ N
Sbjct: 260 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALEN 319
Query: 379 DGYVNVY 385
D + ++
Sbjct: 320 DKTIKLW 326
Score = 114 bits (275), Expect = 6e-25
Identities = 74/225 (32%), Positives = 114/225 (50%), Gaps = 15/225 (6%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP+G+ + S S I+I+G GK E+ L VA+S D + S +
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++DV GK + TL+GH+ + F+P S L+++GS D +K+++V TL
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF-KEHNDQVWGVKFNAESN 187
S H+ V +V F+ G VSGS D R+WD S QC T + N V VKF+
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS---- 219
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
P+ YI+T LDN +K+W Y + +T + +E
Sbjct: 220 ----------PNGKYILTATLDNTLKLWDYSRGRCLKTYTGQKNE 254
Score = 101 bits (241), Expect = 7e-21
Identities = 81/331 (24%), Positives = 147/331 (44%), Gaps = 21/331 (6%)
Query: 102 SQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
+QL L+ S + ++ + + L TL GH V SV FSP+G+ S SADR + +W
Sbjct: 11 AQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA 70
Query: 162 DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK 221
+ + T HN ++ V ++++S++++S S+DK +K+W + K
Sbjct: 71 YDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDK--------------TLKLWDVRSGK 116
Query: 222 LELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV 281
L TL+GH V +P I G+ ++ + S + +
Sbjct: 117 --CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVH 174
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVL-DTRGKFIMSVAWSPDGRYIASGAEGGSV 340
F+ GS + +G + G ++ +G K L D + V +SP+G+YI + ++
Sbjct: 175 FNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTL 234
Query: 341 YLFDVSQGKMLHTIEAHAQAVRSL--AFS-PKTKLLASASNDGYVNVYNIESAALQNKLD 397
L+D S+G+ L T + FS K + S S D V ++N+++ + KL
Sbjct: 235 KLWDYSRGRCLKTYTGQKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 294
Query: 398 -HKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
H +S P +A++A + + L
Sbjct: 295 GHTDVVISAACHPTENLIASAALENDKTIKL 325
Score = 87.8 bits (208), Expect = 7e-17
Identities = 64/256 (25%), Positives = 119/256 (46%), Gaps = 5/256 (1%)
Query: 218 ENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDM 277
EN L TL GH V SV SP+GE +A G+ + + + ++
Sbjct: 27 ENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEI 86
Query: 278 WKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEG 337
+ +S D S++ + + ++ + +G K L ++ ++P I SG+
Sbjct: 87 SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 338 GSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKL 396
+V +++V GK L T+ AH+ V ++ F+ L+ S S DG +++ S L+ +
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
Query: 397 DHKCWAVS-VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTF--EEHTHIVCGVQFNADG 453
D VS V FSP+G+ + T+ D ++++ R L T+ +++ F+ G
Sbjct: 207 DDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGQKNEKYCIFANFSVTG 266
Query: 454 SK-LVSVSKDKSINIY 468
K +VS S+D + I+
Sbjct: 267 GKWIVSGSEDNLVYIW 282
Score = 55.6 bits (128), Expect = 4e-07
Identities = 31/118 (26%), Positives = 61/118 (51%), Gaps = 1/118 (0%)
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDG 411
T+ H +AV S+ FSP + LAS+S D + ++ + L H V +S D
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
R+ +++ D ++++ + + L T + H++ V FN + ++S S D+++ I+E
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Score = 42.3 bits (95), Expect = 0.004
Identities = 32/102 (31%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVS-VCFSPDGQRMATSAADGSIRVVL 427
K +L S+S + V + AL+ L AVS V FSP+G+ +A+S+AD I +
Sbjct: 10 KAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWG 69
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + T H + V +++D S+LVS S DK++ +++
Sbjct: 70 AYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWD 111
>CR457279-1|CAG33560.1| 330|Homo sapiens WDR5B protein.
Length = 330
Score = 122 bits (293), Expect = 4e-27
Identities = 83/287 (28%), Positives = 134/287 (46%), Gaps = 20/287 (6%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
SV +SP+G+++AS + D +I I+ GK TL GH + I + +S DS L++ SDD
Sbjct: 46 SVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDK 105
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+KL+DV TL GH+++V F+P +SGS D TV++W++ + +C T
Sbjct: 106 TLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSA 165
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H+D V V FN S IV+G D L ++W + + L TL +
Sbjct: 166 HSDPVSAVHFNC--------------SGSLIVSGSYDGLCRIWDAASG--QCLKTLVDDD 209
Query: 233 MPVVS-VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV--FSPDGSQ- 288
P VS V SP+G+ I G+ ++ ++ + I FS G +
Sbjct: 210 NPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKW 269
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGA 335
+ +G V ++ + + + L ++S A P IAS A
Sbjct: 270 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
Score = 118 bits (285), Expect = 3e-26
Identities = 86/307 (28%), Positives = 139/307 (45%), Gaps = 22/307 (7%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH ++ S+ FSP+ + L + S D + ++ TL GH + VA+S D
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
R VS S D+T+++WD+ S +C T K H++ V+ FN SN IIS
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS------------- 142
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
G D VK+W + K L TL H PV +V + G I G
Sbjct: 143 -GSFDETVKIWEVKTGKC--LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASG 199
Query: 265 QKIREIQTDSSDMWKIV-FSPDGSQVATGGHTGKVTVYGIINGTVDKVLD--TRGKFIMS 321
Q ++ + D + V FSP+G + T + ++ G K K+ +
Sbjct: 200 QCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIF 259
Query: 322 VAWS-PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS--N 378
+S G++I SG+E VY++++ +++ ++ H V S A P L+ASA+ N
Sbjct: 260 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALEN 319
Query: 379 DGYVNVY 385
D + ++
Sbjct: 320 DKTIKLW 326
Score = 116 bits (280), Expect = 1e-25
Identities = 76/225 (33%), Positives = 114/225 (50%), Gaps = 17/225 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP+G+ + S S I+I+G GK E+ L VA+S D + S +
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++DV GK + TL+GH+ + F+P S L+++GS D +K+++V TL
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF-KEHNDQVWGVKFNAESN 187
S H+ V +V F+ G VSGS D R+WD S QC T + N V VKF+
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS---- 219
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
P+ YI+T LDN +K+W Y + L T GH+
Sbjct: 220 ----------PNGKYILTATLDNTLKLWDYSRGR--CLKTYTGHK 252
Score = 104 bits (249), Expect = 8e-22
Identities = 82/331 (24%), Positives = 148/331 (44%), Gaps = 21/331 (6%)
Query: 102 SQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
+QL L+ S + ++ + + L TL GH V SV FSP+G+ S SADR + +W
Sbjct: 11 AQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA 70
Query: 162 DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK 221
+ + T HN ++ V ++++S++++S S+DK +K+W + K
Sbjct: 71 YDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDK--------------TLKLWDVRSGK 116
Query: 222 LELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV 281
L TL+GH V +P I G+ ++ + S + +
Sbjct: 117 --CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVH 174
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVL-DTRGKFIMSVAWSPDGRYIASGAEGGSV 340
F+ GS + +G + G ++ +G K L D + V +SP+G+YI + ++
Sbjct: 175 FNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTL 234
Query: 341 YLFDVSQGKMLHTIEAHAQAVRSL--AFS-PKTKLLASASNDGYVNVYNIESAALQNKLD 397
L+D S+G+ L T H + FS K + S S D V ++N+++ + KL
Sbjct: 235 KLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 294
Query: 398 -HKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
H +S P +A++A + + L
Sbjct: 295 GHTDVVISAACHPTENLIASAALENDKTIKL 325
Score = 89.0 bits (211), Expect = 3e-17
Identities = 65/256 (25%), Positives = 118/256 (46%), Gaps = 5/256 (1%)
Query: 218 ENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDM 277
EN L TL GH V SV SP+GE +A G+ + + + ++
Sbjct: 27 ENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEI 86
Query: 278 WKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEG 337
+ +S D S++ + + ++ + +G K L ++ ++P I SG+
Sbjct: 87 SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 338 GSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKL 396
+V +++V GK L T+ AH+ V ++ F+ L+ S S DG +++ S L+ +
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
Query: 397 DHKCWAVS-VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH--IVCGVQFNADG 453
D VS V FSP+G+ + T+ D ++++ R L T+ H + F+ G
Sbjct: 207 DDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG 266
Query: 454 SK-LVSVSKDKSINIY 468
K +VS S+D + I+
Sbjct: 267 GKWIVSGSEDNLVYIW 282
Score = 55.6 bits (128), Expect = 4e-07
Identities = 31/118 (26%), Positives = 61/118 (51%), Gaps = 1/118 (0%)
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDG 411
T+ H +AV S+ FSP + LAS+S D + ++ + L H V +S D
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
R+ +++ D ++++ + + L T + H++ V FN + ++S S D+++ I+E
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Score = 42.3 bits (95), Expect = 0.004
Identities = 32/102 (31%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVS-VCFSPDGQRMATSAADGSIRVVL 427
K +L S+S + V + AL+ L AVS V FSP+G+ +A+S+AD I +
Sbjct: 10 KAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWG 69
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + T H + V +++D S+LVS S DK++ +++
Sbjct: 70 AYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWD 111
>BC043494-1|AAH43494.1| 330|Homo sapiens WD repeat domain 5B
protein.
Length = 330
Score = 122 bits (293), Expect = 4e-27
Identities = 83/287 (28%), Positives = 134/287 (46%), Gaps = 20/287 (6%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
SV +SP+G+++AS + D +I I+ GK TL GH + I + +S DS L++ SDD
Sbjct: 46 SVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDK 105
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+KL+DV TL GH+++V F+P +SGS D TV++W++ + +C T
Sbjct: 106 TLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSA 165
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H+D V V FN S IV+G D L ++W + + L TL +
Sbjct: 166 HSDPVSAVHFNC--------------SGSLIVSGSYDGLCRIWDAASG--QCLKTLVDDD 209
Query: 233 MPVVS-VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV--FSPDGSQ- 288
P VS V SP+G+ I G+ ++ ++ + I FS G +
Sbjct: 210 NPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKW 269
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGA 335
+ +G V ++ + + + L ++S A P IAS A
Sbjct: 270 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
Score = 118 bits (285), Expect = 3e-26
Identities = 86/307 (28%), Positives = 139/307 (45%), Gaps = 22/307 (7%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH ++ S+ FSP+ + L + S D + ++ TL GH + VA+S D
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
R VS S D+T+++WD+ S +C T K H++ V+ FN SN IIS
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS------------- 142
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
G D VK+W + K L TL H PV +V + G I G
Sbjct: 143 -GSFDETVKIWEVKTGKC--LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASG 199
Query: 265 QKIREIQTDSSDMWKIV-FSPDGSQVATGGHTGKVTVYGIINGTVDKVLD--TRGKFIMS 321
Q ++ + D + V FSP+G + T + ++ G K K+ +
Sbjct: 200 QCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIF 259
Query: 322 VAWS-PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS--N 378
+S G++I SG+E VY++++ +++ ++ H V S A P L+ASA+ N
Sbjct: 260 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALEN 319
Query: 379 DGYVNVY 385
D + ++
Sbjct: 320 DKTIKLW 326
Score = 116 bits (280), Expect = 1e-25
Identities = 76/225 (33%), Positives = 114/225 (50%), Gaps = 17/225 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++ FSP+G+ + S S I+I+G GK E+ L VA+S D + S +
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++DV GK + TL+GH+ + F+P S L+++GS D +K+++V TL
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF-KEHNDQVWGVKFNAESN 187
S H+ V +V F+ G VSGS D R+WD S QC T + N V VKF+
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS---- 219
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
P+ YI+T LDN +K+W Y + L T GH+
Sbjct: 220 ----------PNGKYILTATLDNTLKLWDYSRGR--CLKTYTGHK 252
Score = 104 bits (249), Expect = 8e-22
Identities = 82/331 (24%), Positives = 148/331 (44%), Gaps = 21/331 (6%)
Query: 102 SQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
+QL L+ S + ++ + + L TL GH V SV FSP+G+ S SADR + +W
Sbjct: 11 AQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA 70
Query: 162 DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK 221
+ + T HN ++ V ++++S++++S S+DK +K+W + K
Sbjct: 71 YDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDK--------------TLKLWDVRSGK 116
Query: 222 LELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV 281
L TL+GH V +P I G+ ++ + S + +
Sbjct: 117 --CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVH 174
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVL-DTRGKFIMSVAWSPDGRYIASGAEGGSV 340
F+ GS + +G + G ++ +G K L D + V +SP+G+YI + ++
Sbjct: 175 FNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTL 234
Query: 341 YLFDVSQGKMLHTIEAHAQAVRSL--AFS-PKTKLLASASNDGYVNVYNIESAALQNKLD 397
L+D S+G+ L T H + FS K + S S D V ++N+++ + KL
Sbjct: 235 KLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 294
Query: 398 -HKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
H +S P +A++A + + L
Sbjct: 295 GHTDVVISAACHPTENLIASAALENDKTIKL 325
Score = 89.0 bits (211), Expect = 3e-17
Identities = 65/256 (25%), Positives = 118/256 (46%), Gaps = 5/256 (1%)
Query: 218 ENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDM 277
EN L TL GH V SV SP+GE +A G+ + + + ++
Sbjct: 27 ENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEI 86
Query: 278 WKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEG 337
+ +S D S++ + + ++ + +G K L ++ ++P I SG+
Sbjct: 87 SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 338 GSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKL 396
+V +++V GK L T+ AH+ V ++ F+ L+ S S DG +++ S L+ +
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
Query: 397 DHKCWAVS-VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH--IVCGVQFNADG 453
D VS V FSP+G+ + T+ D ++++ R L T+ H + F+ G
Sbjct: 207 DDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG 266
Query: 454 SK-LVSVSKDKSINIY 468
K +VS S+D + I+
Sbjct: 267 GKWIVSGSEDNLVYIW 282
Score = 55.6 bits (128), Expect = 4e-07
Identities = 31/118 (26%), Positives = 61/118 (51%), Gaps = 1/118 (0%)
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDG 411
T+ H +AV S+ FSP + LAS+S D + ++ + L H V +S D
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
R+ +++ D ++++ + + L T + H++ V FN + ++S S D+++ I+E
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Score = 42.3 bits (95), Expect = 0.004
Identities = 32/102 (31%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVS-VCFSPDGQRMATSAADGSIRVVL 427
K +L S+S + V + AL+ L AVS V FSP+G+ +A+S+AD I +
Sbjct: 10 KAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWG 69
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + T H + V +++D S+LVS S DK++ +++
Sbjct: 70 AYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWD 111
>BC127949-1|AAI27950.1| 314|Homo sapiens similar to hypothetical
protein FLJ25955 protein.
Length = 314
Score = 115 bits (277), Expect = 3e-25
Identities = 78/284 (27%), Positives = 129/284 (45%), Gaps = 16/284 (5%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
S A+SPDG+ + +G+ DG + ++ G+L+ L GH ++ FSPD L + S D
Sbjct: 26 SSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDC 85
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
++L+DV A L GH V +V+FSPD ++ SG D+ V +WD+ S Q
Sbjct: 86 TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVG 145
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLH-TLEGH 231
H D + S D P+ + + TG D+ V++W + H LEGH
Sbjct: 146 HRDSI--------------QSSDFSPTVNCLATGSWDSTVRIWDLRMVTPAVSHQALEGH 191
Query: 232 EMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
+ + S G +A + +++ + + I FSPD +A+
Sbjct: 192 SGNISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 292 GGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGA 335
G++ V V+ G + L + A++PDG+ + SGA
Sbjct: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGA 294
Score = 110 bits (265), Expect = 9e-24
Identities = 80/294 (27%), Positives = 129/294 (43%), Gaps = 20/294 (6%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H + S FSPD Q+LLTGS+DG + ++ L L GH V FSPDG F
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
S S D TVR+WD+ +C K H V V F+ +S ++ S GG
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS--------------GGW 125
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX---XXXXXXXGQ 265
D V +W ++ ++L L GH + S SP +A
Sbjct: 126 DKRVMLWDVQSG--QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVRIWDLRMVTPAV 183
Query: 266 KIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWS 325
+ ++ S ++ + +S G +A+G + ++ ++ L ++ S+A+S
Sbjct: 184 SHQALEGHSGNISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFS 242
Query: 326 PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASND 379
PD ++AS V ++D + GK L T++ + AF+P K+L S + D
Sbjct: 243 PDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 106 bits (255), Expect = 1e-22
Identities = 81/282 (28%), Positives = 127/282 (45%), Gaps = 20/282 (7%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSV---AYSPDGKYIASGALDG 70
FSPDG+ +++GS G ++G E+ + Q+L G T V +SPDG AS + D
Sbjct: 29 FSPDGQMLLTGSEDG--CVYGWET-RSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDC 85
Query: 71 IINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSG 130
+ ++DVA+ K + L+GH S+ ++ FSPDS+ L +G D + L+DV + L G
Sbjct: 86 TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVG 145
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H + S FSP +GS D TVR+WDL + V S I
Sbjct: 146 HRDSIQSSDFSPTVNCLATGSWDSTVRIWDLRMV---------TPAVSHQALEGHSGNIS 196
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + + +G D + +W + LL L+GH V S+A SPD +A
Sbjct: 197 CLCYS---ASGLLASGSWDKTIHIWKPTTS--SLLIQLKGHVTWVKSIAFSPDELWLASA 251
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATG 292
G+ + ++ F+PDG + +G
Sbjct: 252 GYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSG 293
Score = 98.3 bits (234), Expect = 5e-20
Identities = 60/191 (31%), Positives = 98/191 (51%), Gaps = 4/191 (2%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V T+ FSPD + + SG +++++ V+SG+ ++L S +SP +A+G+
Sbjct: 108 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW 167
Query: 69 DGIINIFD---VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D + I+D V LEGH+ +I LC+S S LL +GS D + ++ ++L
Sbjct: 168 DSTVRIWDLRMVTPAVSHQALEGHSGNISCLCYSA-SGLLASGSWDKTIHIWKPTTSSLL 226
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
L GH +WV S+AFSPD S R V+VWD ++ +C T K D F +
Sbjct: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286
Query: 186 SNKIISVSEDK 196
++S + D+
Sbjct: 287 GKILVSGAADQ 297
Score = 89.8 bits (213), Expect = 2e-17
Identities = 70/271 (25%), Positives = 122/271 (45%), Gaps = 7/271 (2%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P ++TG D V W E +LL L GH PV SPDG A
Sbjct: 31 PDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVR 88
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ +R ++ + + FSPD Q+A+GG +V ++ + +G + ++L
Sbjct: 89 LWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD 148
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFD---VSQGKMLHTIEAHAQAVRSLAFSPKTKLLA 374
I S +SP +A+G+ +V ++D V+ +E H+ + L +S + LLA
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVRIWDLRMVTPAVSHQALEGHSGNISCLCYS-ASGLLA 207
Query: 375 SASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
S S D ++++ +++L +L H W S+ FSPD +A++ ++V +
Sbjct: 208 SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKS 464
L T + + F DG LVS + D++
Sbjct: 268 LETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 87.8 bits (208), Expect = 7e-17
Identities = 77/300 (25%), Positives = 127/300 (42%), Gaps = 21/300 (7%)
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H V S AFSPDG+ ++GS D V W+ S Q H V +F+ + +
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
S S D V++W K L L+GH+ V +V+ SPD +A
Sbjct: 80 SAS--------------CDCTVRLWDVARAKC--LRVLKGHQRSVETVSFSPDSRQLASG 123
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI--INGTV 308
GQ +R + + FSP + +ATG V ++ + + V
Sbjct: 124 GWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVRIWDLRMVTPAV 183
Query: 309 D-KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
+ L+ I + +S G +ASG+ +++++ + +L ++ H V+S+AFS
Sbjct: 184 SHQALEGHSGNISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFS 242
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMATSAADGSIRVV 426
P LASA V V++ + L C F+PDG+ + + AAD + R +
Sbjct: 243 PDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQI 302
Score = 83.0 bits (196), Expect = 2e-15
Identities = 61/244 (25%), Positives = 107/244 (43%), Gaps = 5/244 (2%)
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H V S A SPDG+ + GQ + + + + FSPDG A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 291 TGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM 350
+ V ++ + +VL + + +V++SPD R +ASG V L+DV G+M
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVS-VC 406
L + H +++S FSP LA+ S D V +++ + A L+ +S +C
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVRIWDLRMVTPAVSHQALEGHSGNISCLC 199
Query: 407 FSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSIN 466
+S G +A+ + D +I + +L + H V + F+ D L S + +
Sbjct: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
Query: 467 IYEC 470
+++C
Sbjct: 259 VWDC 262
Score = 70.5 bits (165), Expect = 1e-11
Identities = 44/161 (27%), Positives = 81/161 (50%), Gaps = 1/161 (0%)
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPK 369
K G + S A+SPDG+ + +G+E G VY ++ G++L + H V+ FSP
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
Query: 370 TKLLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
L ASAS D V ++++ A L+ H+ +V FSPD +++A+ D + + +
Sbjct: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ ++L H + F+ + L + S D ++ I++
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVRIWD 175
Score = 67.3 bits (157), Expect = 1e-10
Identities = 47/148 (31%), Positives = 70/148 (47%), Gaps = 4/148 (2%)
Query: 13 DFSPDGKHVISGSNAGKILIFG---VESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALD 69
DFSP + +GS + I+ V Q L+ + YS G +ASG+ D
Sbjct: 154 DFSPTVNCLATGSWDSTVRIWDLRMVTPAVSHQALEGHSGNISCLCYSASG-LLASGSWD 212
Query: 70 GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLS 129
I+I+ L+ L+GH ++S+ FSPD L + +K++D TL
Sbjct: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVR 157
G + AF+PDGK VSG+AD+T R
Sbjct: 273 GVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 33.5 bits (73), Expect = 1.7
Identities = 19/64 (29%), Positives = 33/64 (51%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
+T V ++ FSPD + S + + ++ +GK + L + A++PDGK + S
Sbjct: 233 VTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVS 292
Query: 66 GALD 69
GA D
Sbjct: 293 GAAD 296
>AL354928-6|CAI39637.1| 314|Homo sapiens WD repeat domain 38
protein.
Length = 314
Score = 115 bits (276), Expect = 4e-25
Identities = 78/284 (27%), Positives = 128/284 (45%), Gaps = 16/284 (5%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
S A+SPDG+ + +G+ DG + ++ G+L+ L GH ++ FSPD L + S D
Sbjct: 26 SSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDC 85
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
++L+DV A L GH V +V+FSPD ++ SG D+ V +WD+ S Q
Sbjct: 86 TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVG 145
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLH-TLEGH 231
H D + S D P+ + + TG D+ V +W + H LEGH
Sbjct: 146 HRDSI--------------QSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191
Query: 232 EMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
+ + S G +A + +++ + + I FSPD +A+
Sbjct: 192 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 292 GGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGA 335
G++ V V+ G + L + A++PDG+ + SGA
Sbjct: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGA 294
Score = 111 bits (266), Expect = 7e-24
Identities = 80/294 (27%), Positives = 130/294 (44%), Gaps = 20/294 (6%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H + S FSPD Q+LLTGS+DG + ++ L L GH V FSPDG F
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
S S D TVR+WD+ +C K H V V F+ +S ++ S GG
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS--------------GGW 125
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX---XXXXXXXGQ 265
D V +W ++ ++L L GH + S SP +A
Sbjct: 126 DKRVMLWDVQSG--QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAV 183
Query: 266 KIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWS 325
+ ++ S+++ + +S G +A+G + ++ ++ L ++ S+A+S
Sbjct: 184 SHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFS 242
Query: 326 PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASND 379
PD ++AS V ++D + GK L T++ + AF+P K+L S + D
Sbjct: 243 PDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 105 bits (251), Expect = 5e-22
Identities = 80/282 (28%), Positives = 127/282 (45%), Gaps = 20/282 (7%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSV---AYSPDGKYIASGALDG 70
FSPDG+ +++GS G ++G E+ + Q+L G T V +SPDG AS + D
Sbjct: 29 FSPDGQMLLTGSEDG--CVYGWET-RSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDC 85
Query: 71 IINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSG 130
+ ++DVA+ K + L+GH S+ ++ FSPDS+ L +G D + L+DV + L G
Sbjct: 86 TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVG 145
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H + S FSP +GS D TV +WDL + V A
Sbjct: 146 HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV------------TPAVSHQALEGHSA 193
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
++S + + +G D + +W + LL L+GH V S+A SPD +A
Sbjct: 194 NISCLCYSASGLLASGSWDKTIHIWKPTTS--SLLIQLKGHVTWVKSIAFSPDELWLASA 251
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATG 292
G+ + ++ F+PDG + +G
Sbjct: 252 GYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSG 293
Score = 99.5 bits (237), Expect = 2e-20
Identities = 60/191 (31%), Positives = 99/191 (51%), Gaps = 4/191 (2%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V T+ FSPD + + SG +++++ V+SG+ ++L S +SP +A+G+
Sbjct: 108 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW 167
Query: 69 DGIINIFD---VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D ++I+D V LEGH+ +I LC+S S LL +GS D + ++ ++L
Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLASGSWDKTIHIWKPTTSSLL 226
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
L GH +WV S+AFSPD S R V+VWD ++ +C T K D F +
Sbjct: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286
Query: 186 SNKIISVSEDK 196
++S + D+
Sbjct: 287 GKILVSGAADQ 297
Score = 91.9 bits (218), Expect = 5e-18
Identities = 70/271 (25%), Positives = 123/271 (45%), Gaps = 7/271 (2%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P ++TG D V W E +LL L GH PV SPDG A
Sbjct: 31 PDGQMLLTGSEDGCVYGW--ETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVR 88
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ +R ++ + + FSPD Q+A+GG +V ++ + +G + ++L
Sbjct: 89 LWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD 148
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFD---VSQGKMLHTIEAHAQAVRSLAFSPKTKLLA 374
I S +SP +A+G+ +V+++D V+ +E H+ + L +S + LLA
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS-ASGLLA 207
Query: 375 SASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
S S D ++++ +++L +L H W S+ FSPD +A++ ++V +
Sbjct: 208 SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKS 464
L T + + F DG LVS + D++
Sbjct: 268 LETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 87.8 bits (208), Expect = 7e-17
Identities = 77/300 (25%), Positives = 127/300 (42%), Gaps = 21/300 (7%)
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H V S AFSPDG+ ++GS D V W+ S Q H V +F+ + +
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
S S D V++W K L L+GH+ V +V+ SPD +A
Sbjct: 80 SAS--------------CDCTVRLWDVARAKC--LRVLKGHQRSVETVSFSPDSRQLASG 123
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI--INGTV 308
GQ +R + + FSP + +ATG V ++ + + V
Sbjct: 124 GWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAV 183
Query: 309 D-KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
+ L+ I + +S G +ASG+ +++++ + +L ++ H V+S+AFS
Sbjct: 184 SHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFS 242
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMATSAADGSIRVV 426
P LASA V V++ + L C F+PDG+ + + AAD + R +
Sbjct: 243 PDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQI 302
Score = 83.8 bits (198), Expect = 1e-15
Identities = 61/244 (25%), Positives = 107/244 (43%), Gaps = 5/244 (2%)
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H V S A SPDG+ + GQ + + + + FSPDG A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 291 TGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM 350
+ V ++ + +VL + + +V++SPD R +ASG V L+DV G+M
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLD-HKCWAVSVC 406
L + H +++S FSP LA+ S D V++++ + A L+ H +C
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
Query: 407 FSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSIN 466
+S G +A+ + D +I + +L + H V + F+ D L S + +
Sbjct: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
Query: 467 IYEC 470
+++C
Sbjct: 259 VWDC 262
Score = 70.9 bits (166), Expect = 9e-12
Identities = 44/161 (27%), Positives = 82/161 (50%), Gaps = 1/161 (0%)
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPK 369
K G + S A+SPDG+ + +G+E G VY ++ G++L + H V+ FSP
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
Query: 370 TKLLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
L ASAS D V ++++ A L+ H+ +V FSPD +++A+ D + + +
Sbjct: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ ++L H + F+ + L + S D +++I++
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
Score = 67.3 bits (157), Expect = 1e-10
Identities = 47/148 (31%), Positives = 70/148 (47%), Gaps = 4/148 (2%)
Query: 13 DFSPDGKHVISGSNAGKILIFG---VESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALD 69
DFSP + +GS + I+ V Q L+ + YS G +ASG+ D
Sbjct: 154 DFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWD 212
Query: 70 GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLS 129
I+I+ L+ L+GH ++S+ FSPD L + +K++D TL
Sbjct: 213 KTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLK 272
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVR 157
G + AF+PDGK VSG+AD+T R
Sbjct: 273 GVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 33.5 bits (73), Expect = 1.7
Identities = 19/64 (29%), Positives = 33/64 (51%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
+T V ++ FSPD + S + + ++ +GK + L + A++PDGK + S
Sbjct: 233 VTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVS 292
Query: 66 GALD 69
GA D
Sbjct: 293 GAAD 296
>AJ243107-1|CAB56462.1| 1171|Homo sapiens apoptotic protease
activating factor-1 protein.
Length = 1171
Score = 113 bits (273), Expect = 1e-24
Identities = 105/458 (22%), Positives = 190/458 (41%), Gaps = 14/458 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 631 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 690
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 691 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 750
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + K N + + + +
Sbjct: 751 TNSVNHCRFSPDDKPLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQEDMEV 807
Query: 192 VSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + S D + N + +W+ ++ + GH V V SPDG +
Sbjct: 808 IVKCCSWSADGARIMVAAKNKIFLWNTDSR--SKVADCRGHLSWVHGVMFSPDGSSFLTS 865
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK 310
K + +VF + V H ++ + G +D
Sbjct: 866 SDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 923
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKT 370
+ + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 924 LTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 980
Query: 371 KLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 981 KTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1039
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1040 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1077
Score = 87.4 bits (207), Expect = 1e-16
Identities = 84/395 (21%), Positives = 162/395 (41%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 622 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 681
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 682 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 729
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 730 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKPLASCSADGTLKLWDATSANERK 787
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ + KV D R
Sbjct: 788 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWN--TDSRSKVADCR 844
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 845 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 902
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 903 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 960
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 961 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 995
Score = 62.1 bits (144), Expect = 4e-09
Identities = 78/386 (20%), Positives = 146/386 (37%), Gaps = 50/386 (12%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGK-------------LVHTLEGHAMSIRSLCFSPDS 102
+SPD K +AS + DG + ++D L E + ++ +S D
Sbjct: 759 FSPDDKPLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADG 818
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 819 ARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 877
Query: 163 SMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKL 222
+ C+++ +V V F +++V + TG +D L
Sbjct: 878 KV-CKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT---------- 925
Query: 223 ELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVF 282
E V +SP + IA + + +W I F
Sbjct: 926 ---------EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQF 976
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG--KFIMSVAWSPDGRYIASGAEGGSV 340
+ D + + ++ V+ N +DK + RG + + + R + S + G+V
Sbjct: 977 TADEKTLISSSDDAEIQVW---NWQLDKCIFLRGHQETVKDFRLLKNSRLL-SWSFDGTV 1032
Query: 341 YLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL-------- 392
++++ G H V S S +S S D ++N+ + L
Sbjct: 1033 KVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWNVSNGELLHLCAPLS 1092
Query: 393 -QNKLDHKCWAVSVCFSPDGQRMATS 417
+ H W +CFSPDG+ + ++
Sbjct: 1093 EEGAATHGGWVTDLCFSPDGKMLISA 1118
Score = 58.8 bits (136), Expect = 4e-08
Identities = 39/154 (25%), Positives = 74/154 (48%), Gaps = 2/154 (1%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 935 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 994
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 995 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1052
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
VLS S D +F S SAD+T ++W++ + + H
Sbjct: 1053 VLSCDISHDATKFSSTSADKTAKIWNVSNGELLH 1086
Score = 58.4 bits (135), Expect = 5e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 626 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 685
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 686 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 745
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 746 TMFGHTNSVNHCRFSPDDKPLASCSADGTLKLWD 779
Score = 57.2 bits (132), Expect = 1e-07
Identities = 56/240 (23%), Positives = 98/240 (40%), Gaps = 12/240 (5%)
Query: 57 SPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
SP +YIA G +G I I ++ ++ + H ++ + F+ D + L++ SDD +++
Sbjct: 935 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 994
Query: 117 YDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQ 176
++ + L GH V + R +S S D TV+VW++ + + F H
Sbjct: 995 WNW-QLDKCIFLRGHQETVKDFRLLKNS-RLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1052
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVV 236
V + ++ K S S DK + G L +L S E H V
Sbjct: 1053 VLSCDISHDATKFSSTSADKTAKIWNVSNGELLHLCAPLSEEG--------AATHGGWVT 1104
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
+ SPDG+ + G+ + T+ +++ KI SPD T + G
Sbjct: 1105 DLCFSPDGKML--ISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1162
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 605 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 664
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 665 EDEVLCCAFSTDDRFIATCSVDKKVKIW 692
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1102 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1159
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1160 NL-GILYILQTLE 1171
Score = 32.7 bits (71), Expect = 2.9
Identities = 18/67 (26%), Positives = 33/67 (49%), Gaps = 2/67 (2%)
Query: 41 EQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP 100
E+ T G + + +SPDGK + S G I ++V G+ T + +++ + SP
Sbjct: 1093 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1150
Query: 101 DSQLLLT 107
D + +T
Sbjct: 1151 DFKTYVT 1157
>AJ243005-1|CAB55581.1| 1205|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1205
Score = 113 bits (273), Expect = 1e-24
Identities = 105/458 (22%), Positives = 190/458 (41%), Gaps = 14/458 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + K N + + + +
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQGDMEV 799
Query: 192 VSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + S D + N + +W+ ++ + GH V V SPDG +
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLWNTDSR--SKVTDCRGHLSWVHGVMFSPDGSSFLTS 857
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK 310
K + +VF + V H ++ + G +D
Sbjct: 858 SDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 915
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKT 370
+ + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 916 LTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 972
Query: 371 KLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 973 KTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1031
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Score = 87.4 bits (207), Expect = 1e-16
Identities = 84/395 (21%), Positives = 162/395 (41%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ + KV D R
Sbjct: 780 SINVKQFFLNLEDPQGDMEVIVKCCSWSADGARIMVAA-KNKIFLWN--TDSRSKVTDCR 836
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 894
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 895 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 953 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 987
Score = 77.8 bits (183), Expect = 8e-14
Identities = 88/410 (21%), Positives = 165/410 (40%), Gaps = 56/410 (13%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTL------------EGHAMSIRSLC-FSPDS 102
+SPD K +AS + DG + ++D ++ +G I C +S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQGDMEVIVKCCSWSADG 810
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 811 ARIMVAAKN-KIFLWNTDSRSKVTDCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 869
Query: 163 SMQCQHT-----------FKEHNDQVWGVK-------FNAESNKIISVSEDK------GP 198
+ C+++ F+E+ V V N + +I ++E + P
Sbjct: 870 KV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 928
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
YI G + +++ NN++ + H+ V + + D +T+
Sbjct: 929 HLQYIAFGDENGAIEILELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 259 XXXXXGQKI--REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I R Q D + S++ + G V V+ II G +K
Sbjct: 987 WNWQLDKCIFLRGHQETVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQ 1042
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
++S S D +S + + ++ LH + H VR AFS + LLA+
Sbjct: 1043 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1102
Query: 377 SNDGYVNVYNIESAAL---------QNKLDHKCWAVSVCFSPDGQRMATS 417
++G + ++N+ + L + H W +CFSPDG+ + ++
Sbjct: 1103 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1152
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1103
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1153
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1154 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1196
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 847 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 902
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 903 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 959
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 960 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1017
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1018 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1061
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1062 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1121
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1122 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1179
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1180 IHVSPDFKTYVTVDNLGILYI 1200
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1105 NGEIRIW 1111
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1136 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1193
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1194 NL-GILYILQTLE 1205
>AJ243004-1|CAB55580.1| 1205|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1205
Score = 113 bits (273), Expect = 1e-24
Identities = 105/458 (22%), Positives = 190/458 (41%), Gaps = 14/458 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + K N + + + +
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQEDMEV 799
Query: 192 VSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + S D + N + +W+ ++ + GH V V SPDG +
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLWNTDSR--SKVADCRGHLSWVHGVMFSPDGSSFLTS 857
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK 310
K + +VF + V H ++ + G +D
Sbjct: 858 SDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 915
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKT 370
+ + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 916 LTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 972
Query: 371 KLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 973 KTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1031
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Score = 87.4 bits (207), Expect = 1e-16
Identities = 84/395 (21%), Positives = 162/395 (41%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ + KV D R
Sbjct: 780 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWN--TDSRSKVADCR 836
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 894
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 895 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 953 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 987
Score = 79.4 bits (187), Expect = 3e-14
Identities = 87/410 (21%), Positives = 164/410 (40%), Gaps = 56/410 (13%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGK-------------LVHTLEGHAMSIRSLCFSPDS 102
+SPD K +AS + DG + ++D L E + ++ +S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADG 810
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 811 ARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 869
Query: 163 SMQCQHT-----------FKEHNDQVWGVK-------FNAESNKIISVSEDK------GP 198
+ C+++ F+E+ V V N + +I ++E + P
Sbjct: 870 KV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 928
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
YI G + +++ NN++ + H+ V + + D +T+
Sbjct: 929 HLQYIAFGDENGAIEILELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 259 XXXXXGQKI--REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I R Q D + S++ + G V V+ II G +K
Sbjct: 987 WNWQLDKCIFLRGHQETVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQ 1042
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
++S S D +S + + ++ LH + H VR AFS + LLA+
Sbjct: 1043 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1102
Query: 377 SNDGYVNVYNIESAAL---------QNKLDHKCWAVSVCFSPDGQRMATS 417
++G + ++N+ + L + H W +CFSPDG+ + ++
Sbjct: 1103 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1152
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1103
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1153
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1154 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1196
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 847 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 902
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 903 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 959
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 960 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1017
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1018 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1061
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1062 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1121
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1122 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1179
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1180 IHVSPDFKTYVTVDNLGILYI 1200
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1105 NGEIRIW 1111
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1136 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1193
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1194 NL-GILYILQTLE 1205
>AJ243003-1|CAB55579.1| 1205|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1205
Score = 113 bits (273), Expect = 1e-24
Identities = 105/458 (22%), Positives = 190/458 (41%), Gaps = 14/458 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFANSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + K N + + + +
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQEDMEV 799
Query: 192 VSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + S D + N + +W+ ++ + GH V V SPDG +
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLWNTDSR--SKVADCRGHLSWVHGVMFSPDGSSFLTS 857
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK 310
K + +VF + V H ++ + G +D
Sbjct: 858 SDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 915
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKT 370
+ + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 916 LTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 972
Query: 371 KLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 973 KTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1031
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Score = 86.6 bits (205), Expect = 2e-16
Identities = 84/395 (21%), Positives = 162/395 (41%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFANSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ + KV D R
Sbjct: 780 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWN--TDSRSKVADCR 836
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 894
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 895 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 953 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 987
Score = 79.4 bits (187), Expect = 3e-14
Identities = 87/410 (21%), Positives = 164/410 (40%), Gaps = 56/410 (13%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGK-------------LVHTLEGHAMSIRSLCFSPDS 102
+SPD K +AS + DG + ++D L E + ++ +S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADG 810
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 811 ARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 869
Query: 163 SMQCQHT-----------FKEHNDQVWGVK-------FNAESNKIISVSEDK------GP 198
+ C+++ F+E+ V V N + +I ++E + P
Sbjct: 870 KV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 928
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
YI G + +++ NN++ + H+ V + + D +T+
Sbjct: 929 HLQYIAFGDENGAIEILELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 259 XXXXXGQKI--REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I R Q D + S++ + G V V+ II G +K
Sbjct: 987 WNWQLDKCIFLRGHQETVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQ 1042
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
++S S D +S + + ++ LH + H VR AFS + LLA+
Sbjct: 1043 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1102
Query: 377 SNDGYVNVYNIESAAL---------QNKLDHKCWAVSVCFSPDGQRMATS 417
++G + ++N+ + L + H W +CFSPDG+ + ++
Sbjct: 1103 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1152
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1103
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1153
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1154 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1196
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 847 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 902
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 903 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 959
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 960 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1017
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1018 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1061
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1062 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1121
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1122 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1179
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1180 IHVSPDFKTYVTVDNLGILYI 1200
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFANSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1105 NGEIRIW 1111
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1136 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1193
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1194 NL-GILYILQTLE 1205
>AF013263-1|AAC51678.1| 1194|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1194
Score = 113 bits (273), Expect = 1e-24
Identities = 105/458 (22%), Positives = 190/458 (41%), Gaps = 14/458 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + K N + + + +
Sbjct: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQEDMEV 788
Query: 192 VSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + S D + N + +W+ ++ + GH V V SPDG +
Sbjct: 789 IVKCCSWSADGARIMVAAKNKIFLWNTDSR--SKVADCRGHLSWVHGVMFSPDGSSFLTS 846
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK 310
K + +VF + V H ++ + G +D
Sbjct: 847 SDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 904
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKT 370
+ + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 905 LTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 961
Query: 371 KLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 962 KTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1020
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1021 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1058
Score = 87.4 bits (207), Expect = 1e-16
Identities = 84/395 (21%), Positives = 162/395 (41%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 710
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 711 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 768
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ + KV D R
Sbjct: 769 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWN--TDSRSKVADCR 825
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 883
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 884 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 941
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 942 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 976
Score = 79.4 bits (187), Expect = 3e-14
Identities = 87/410 (21%), Positives = 164/410 (40%), Gaps = 56/410 (13%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGK-------------LVHTLEGHAMSIRSLCFSPDS 102
+SPD K +AS + DG + ++D L E + ++ +S D
Sbjct: 740 FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADG 799
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 800 ARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 858
Query: 163 SMQCQHT-----------FKEHNDQVWGVK-------FNAESNKIISVSEDK------GP 198
+ C+++ F+E+ V V N + +I ++E + P
Sbjct: 859 KV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 917
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
YI G + +++ NN++ + H+ V + + D +T+
Sbjct: 918 HLQYIAFGDENGAIEILELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 975
Query: 259 XXXXXGQKI--REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I R Q D + S++ + G V V+ II G +K
Sbjct: 976 WNWQLDKCIFLRGHQETVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQ 1031
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
++S S D +S + + ++ LH + H VR AFS + LLA+
Sbjct: 1032 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1091
Query: 377 SNDGYVNVYNIESAAL---------QNKLDHKCWAVSVCFSPDGQRMATS 417
++G + ++N+ + L + H W +CFSPDG+ + ++
Sbjct: 1092 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1141
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 916 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 975
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 976 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1033
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1034 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1092
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1093 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1142
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1143 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1185
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 836 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 891
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 892 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 948
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 949 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1006
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1007 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1050
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1051 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1110
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1111 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1168
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1169 IHVSPDFKTYVTVDNLGILYI 1189
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 607 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 666
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 667 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 726
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 916 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 975
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 976 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1033
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1034 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1093
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1094 NGEIRIW 1100
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 586 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 645
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 646 EDEVLCCAFSTDDRFIATCSVDKKVKIW 673
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1125 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1182
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1183 NL-GILYILQTLE 1194
>EF011619-1|ABK41109.1| 478|Homo sapiens CDW9/WDR51B protein.
Length = 478
Score = 113 bits (272), Expect = 1e-24
Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 16/293 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
+ +LD SP+GK + + S ++++ + + SV +SP G +AS +
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ + + H +RS+ FS D Q L T S+D +K++ + +L
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
H WV FSPDG+ VS S D+T+++WD + QC + F +D V F
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF---SDSVGFANF------ 191
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
D PS I + G D VKVW NK LL + H V ++ P G +
Sbjct: 192 -----VDFNPSGTCIASAGSDQTVKVWDVRVNK--LLQHYQVHSGGVNCISFHPSGNYLI 244
Query: 249 XXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
G+ I +Q + ++ + FS G A+GG +V ++
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 110 bits (264), Expect = 1e-23
Identities = 82/297 (27%), Positives = 130/297 (43%), Gaps = 18/297 (6%)
Query: 87 EGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKR 146
+GH +I SL SP+ + L T S D + L++ A GH V SV FSP G
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
Query: 147 FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTG 206
S S DRTVR+W D FK H V V F+A+ + + SEDK
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKS--------- 125
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK 266
+KVWS + L++L H V SPDG I Q
Sbjct: 126 -----IKVWSMYRQR--FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
Query: 267 IREIQTDSSDMWKIV-FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWS 325
+ +DS V F+P G+ +A+ G V V+ + + + + +++
Sbjct: 179 VNNF-SDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH 237
Query: 326 PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
P G Y+ + + G++ + D+ +G++++T++ H V +++FS +L AS D V
Sbjct: 238 PSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Score = 97.9 bits (233), Expect = 7e-20
Identities = 64/285 (22%), Positives = 125/285 (43%), Gaps = 3/285 (1%)
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
+ +K S D P+ + T D + +W+++ + + GH+ V SV SP G
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV--GHKDVVTSVQFSPHG 72
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
+A K E + ++ + + FS DG +AT + V+ +
Sbjct: 73 NLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSL 364
L ++ +SPDGR I S +E ++ ++D + + ++ +
Sbjct: 133 RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFV 192
Query: 365 AFSPKTKLLASASNDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSI 423
F+P +ASA +D V V+++ + LQ+ H + F P G + T+++DG++
Sbjct: 193 DFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252
Query: 424 RVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+++ L E R+++T + HT V V F+ G S D + ++
Sbjct: 253 KILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 93.5 bits (222), Expect = 1e-18
Identities = 51/162 (31%), Positives = 80/162 (49%), Gaps = 2/162 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S I I+ + + F V ++P G IAS D +
Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 211
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV KL+ + H+ + + F P L+T S DG +K+ D++ L TL GH
Sbjct: 212 VWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEH 173
V +V+FS G+ F SG AD V +W + D + C+ K +
Sbjct: 272 PVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRN 313
Score = 87.4 bits (207), Expect = 1e-16
Identities = 70/296 (23%), Positives = 124/296 (41%), Gaps = 19/296 (6%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
GH + + S+ SP+GK+ + S D + +W+ + + H D V V+F+ N +
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 190 ISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAX 249
S S D+ V++W + K + H PV SV S DG+ +A
Sbjct: 76 ASASRDR--------------TVRLWIPD--KRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
Query: 250 XXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-V 308
+ + + + + FSPDG + + + ++ N V
Sbjct: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
Query: 309 DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP 368
+ D+ G F V ++P G IAS +V ++DV K+L + H+ V ++F P
Sbjct: 180 NNFSDSVG-FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP 238
Query: 369 KTKLLASASNDGYVNVYN-IESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSI 423
L +AS+DG + + + +E + H +V FS G+ A+ AD +
Sbjct: 239 SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Score = 80.6 bits (190), Expect = 1e-14
Identities = 51/152 (33%), Positives = 81/152 (53%), Gaps = 1/152 (0%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
I S+ SP+G+ +A+ + + L++ + H V S+ FSP LLASAS
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 379 DGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTF 437
D V ++ + ++ H SV FS DGQ +AT++ D SI+V + R L++
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 438 EEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
HTH V +F+ DG +VS S+DK+I I++
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Score = 68.1 bits (159), Expect = 6e-11
Identities = 45/188 (23%), Positives = 85/188 (45%), Gaps = 1/188 (0%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP+G Q+AT + ++ + SV +SP G +AS + +V L
Sbjct: 27 SPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRL 86
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+ + +AH VRS+ FS + LA+AS D + V+++ L + H W
Sbjct: 87 WIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHW 146
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
FSPDG+ + + + D +I++ + ++ F + V FN G+ + S
Sbjct: 147 VRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGS 206
Query: 462 DKSINIYE 469
D+++ +++
Sbjct: 207 DQTVKVWD 214
Score = 68.1 bits (159), Expect = 6e-11
Identities = 43/182 (23%), Positives = 81/182 (44%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
F+ V ++DFS DG+ + + S I ++ + + L + +SPDG+
Sbjct: 98 FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
I S + D I I+D + V+ + F+P + + D +K++DV
Sbjct: 158 LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
L H+ V ++F P G ++ S+D T+++ DL + +T + H V+ V
Sbjct: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277
Query: 182 FN 183
F+
Sbjct: 278 FS 279
Score = 43.6 bits (98), Expect = 0.002
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 3/81 (3%)
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
HK S+ SP+G+++AT++ D + + + + + H +V VQF+ G+ L
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 458 SVSKDKSINIYECPIPPKSAK 478
S S+D+++ ++ IP K K
Sbjct: 77 SASRDRTVRLW---IPDKRGK 94
>BC026080-1|AAH26080.1| 478|Homo sapiens WD repeat domain 51B
protein.
Length = 478
Score = 113 bits (272), Expect = 1e-24
Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 16/293 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
+ +LD SP+GK + + S ++++ + + SV +SP G +AS +
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ + + H +RS+ FS D Q L T S+D +K++ + +L
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
H WV FSPDG+ VS S D+T+++WD + QC + F +D V F
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF---SDSVGFANF------ 191
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
D PS I + G D VKVW NK LL + H V ++ P G +
Sbjct: 192 -----VDFNPSGTCIASAGSDQTVKVWDVRVNK--LLQHYQVHSGGVNCISFHPSGNYLI 244
Query: 249 XXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
G+ I +Q + ++ + FS G A+GG +V ++
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 110 bits (264), Expect = 1e-23
Identities = 82/297 (27%), Positives = 130/297 (43%), Gaps = 18/297 (6%)
Query: 87 EGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKR 146
+GH +I SL SP+ + L T S D + L++ A GH V SV FSP G
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
Query: 147 FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTG 206
S S DRTVR+W D FK H V V F+A+ + + SEDK
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKS--------- 125
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK 266
+KVWS + L++L H V SPDG I Q
Sbjct: 126 -----IKVWSMYRQR--FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
Query: 267 IREIQTDSSDMWKIV-FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWS 325
+ +DS V F+P G+ +A+ G V V+ + + + + +++
Sbjct: 179 VNNF-SDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH 237
Query: 326 PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
P G Y+ + + G++ + D+ +G++++T++ H V +++FS +L AS D V
Sbjct: 238 PSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Score = 97.9 bits (233), Expect = 7e-20
Identities = 64/285 (22%), Positives = 125/285 (43%), Gaps = 3/285 (1%)
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
+ +K S D P+ + T D + +W+++ + + GH+ V SV SP G
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV--GHKDVVTSVQFSPHG 72
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
+A K E + ++ + + FS DG +AT + V+ +
Sbjct: 73 NLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSL 364
L ++ +SPDGR I S +E ++ ++D + + ++ +
Sbjct: 133 RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFV 192
Query: 365 AFSPKTKLLASASNDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSI 423
F+P +ASA +D V V+++ + LQ+ H + F P G + T+++DG++
Sbjct: 193 DFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252
Query: 424 RVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+++ L E R+++T + HT V V F+ G S D + ++
Sbjct: 253 KILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 93.5 bits (222), Expect = 1e-18
Identities = 51/162 (31%), Positives = 80/162 (49%), Gaps = 2/162 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S I I+ + + F V ++P G IAS D +
Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 211
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV KL+ + H+ + + F P L+T S DG +K+ D++ L TL GH
Sbjct: 212 VWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEH 173
V +V+FS G+ F SG AD V +W + D + C+ K +
Sbjct: 272 PVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRN 313
Score = 87.4 bits (207), Expect = 1e-16
Identities = 70/296 (23%), Positives = 124/296 (41%), Gaps = 19/296 (6%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
GH + + S+ SP+GK+ + S D + +W+ + + H D V V+F+ N +
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 190 ISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAX 249
S S D+ V++W + K + H PV SV S DG+ +A
Sbjct: 76 ASASRDR--------------TVRLWIPD--KRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
Query: 250 XXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-V 308
+ + + + + FSPDG + + + ++ N V
Sbjct: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
Query: 309 DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP 368
+ D+ G F V ++P G IAS +V ++DV K+L + H+ V ++F P
Sbjct: 180 NNFSDSVG-FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP 238
Query: 369 KTKLLASASNDGYVNVYN-IESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSI 423
L +AS+DG + + + +E + H +V FS G+ A+ AD +
Sbjct: 239 SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Score = 80.6 bits (190), Expect = 1e-14
Identities = 51/152 (33%), Positives = 81/152 (53%), Gaps = 1/152 (0%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
I S+ SP+G+ +A+ + + L++ + H V S+ FSP LLASAS
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 379 DGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTF 437
D V ++ + ++ H SV FS DGQ +AT++ D SI+V + R L++
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 438 EEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
HTH V +F+ DG +VS S+DK+I I++
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Score = 68.1 bits (159), Expect = 6e-11
Identities = 45/188 (23%), Positives = 85/188 (45%), Gaps = 1/188 (0%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP+G Q+AT + ++ + SV +SP G +AS + +V L
Sbjct: 27 SPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRL 86
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+ + +AH VRS+ FS + LA+AS D + V+++ L + H W
Sbjct: 87 WIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHW 146
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
FSPDG+ + + + D +I++ + ++ F + V FN G+ + S
Sbjct: 147 VRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGS 206
Query: 462 DKSINIYE 469
D+++ +++
Sbjct: 207 DQTVKVWD 214
Score = 68.1 bits (159), Expect = 6e-11
Identities = 43/182 (23%), Positives = 81/182 (44%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
F+ V ++DFS DG+ + + S I ++ + + L + +SPDG+
Sbjct: 98 FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
I S + D I I+D + V+ + F+P + + D +K++DV
Sbjct: 158 LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
L H+ V ++F P G ++ S+D T+++ DL + +T + H V+ V
Sbjct: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277
Query: 182 FN 183
F+
Sbjct: 278 FS 279
Score = 43.6 bits (98), Expect = 0.002
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 3/81 (3%)
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
HK S+ SP+G+++AT++ D + + + + + H +V VQF+ G+ L
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 458 SVSKDKSINIYECPIPPKSAK 478
S S+D+++ ++ IP K K
Sbjct: 77 SASRDRTVRLW---IPDKRGK 94
>AK074772-1|BAC11198.1| 478|Homo sapiens protein ( Homo sapiens
cDNA FLJ90291 fis, clone NT2RP1001031, weakly similar to
VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1. ).
Length = 478
Score = 113 bits (272), Expect = 1e-24
Identities = 77/293 (26%), Positives = 127/293 (43%), Gaps = 16/293 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
+ +LD SP+GK + + S ++++ + + SV +SP G +AS +
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ + + H +RS+ FS D Q L T S+D +K++ + +L
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
H WV FSPDG+ VS S D+T+++WD + QC + F +D V F
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF---SDSVGFANF------ 191
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
D PS I + G D VKVW NK LL + H V ++ P G +
Sbjct: 192 -----VDFNPSGTCIASAGSDQTVKVWDVRVNK--LLQHYQVHSGGVNCISFHPSGNYLI 244
Query: 249 XXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
G+ I +Q + ++ + FS G A+GG +V ++
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 110 bits (264), Expect = 1e-23
Identities = 82/297 (27%), Positives = 130/297 (43%), Gaps = 18/297 (6%)
Query: 87 EGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKR 146
+GH +I SL SP+ + L T S D + L++ A GH V SV FSP G
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
Query: 147 FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTG 206
S S DRTVR+W D FK H V V F+A+ + + SEDK
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKS--------- 125
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK 266
+KVWS + L++L H V SPDG I Q
Sbjct: 126 -----IKVWSMYRQR--FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
Query: 267 IREIQTDSSDMWKIV-FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWS 325
+ +DS V F+P G+ +A+ G V V+ + + + + +++
Sbjct: 179 VNNF-SDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH 237
Query: 326 PDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
P G Y+ + + G++ + D+ +G++++T++ H V +++FS +L AS D V
Sbjct: 238 PSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Score = 97.9 bits (233), Expect = 7e-20
Identities = 64/285 (22%), Positives = 125/285 (43%), Gaps = 3/285 (1%)
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
+ +K S D P+ + T D + +W+++ + + GH+ V SV SP G
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV--GHKDVVTSVQFSPHG 72
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
+A K E + ++ + + FS DG +AT + V+ +
Sbjct: 73 NLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSL 364
L ++ +SPDGR I S +E ++ ++D + + ++ +
Sbjct: 133 RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFV 192
Query: 365 AFSPKTKLLASASNDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSI 423
F+P +ASA +D V V+++ + LQ+ H + F P G + T+++DG++
Sbjct: 193 DFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252
Query: 424 RVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+++ L E R+++T + HT V V F+ G S D + ++
Sbjct: 253 KILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 93.5 bits (222), Expect = 1e-18
Identities = 51/162 (31%), Positives = 80/162 (49%), Gaps = 2/162 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S I I+ + + F V ++P G IAS D +
Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 211
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV KL+ + H+ + + F P L+T S DG +K+ D++ L TL GH
Sbjct: 212 VWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEH 173
V +V+FS G+ F SG AD V +W + D + C+ K +
Sbjct: 272 PVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRN 313
Score = 87.4 bits (207), Expect = 1e-16
Identities = 70/296 (23%), Positives = 124/296 (41%), Gaps = 19/296 (6%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
GH + + S+ SP+GK+ + S D + +W+ + + H D V V+F+ N +
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 190 ISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAX 249
S S D+ V++W + K + H PV SV S DG+ +A
Sbjct: 76 ASASRDR--------------TVRLWIPD--KRGKFSEFKAHTAPVRSVDFSADGQFLAT 119
Query: 250 XXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-V 308
+ + + + + FSPDG + + + ++ N V
Sbjct: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
Query: 309 DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP 368
+ D+ G F V ++P G IAS +V ++DV K+L + H+ V ++F P
Sbjct: 180 NNFSDSVG-FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP 238
Query: 369 KTKLLASASNDGYVNVYN-IESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSI 423
L +AS+DG + + + +E + H +V FS G+ A+ AD +
Sbjct: 239 SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Score = 80.6 bits (190), Expect = 1e-14
Identities = 51/152 (33%), Positives = 81/152 (53%), Gaps = 1/152 (0%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
I S+ SP+G+ +A+ + + L++ + H V S+ FSP LLASAS
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 379 DGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTF 437
D V ++ + ++ H SV FS DGQ +AT++ D SI+V + R L++
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 438 EEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
HTH V +F+ DG +VS S+DK+I I++
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Score = 68.1 bits (159), Expect = 6e-11
Identities = 45/188 (23%), Positives = 85/188 (45%), Gaps = 1/188 (0%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP+G Q+AT + ++ + SV +SP G +AS + +V L
Sbjct: 27 SPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRL 86
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+ + +AH VRS+ FS + LA+AS D + V+++ L + H W
Sbjct: 87 WIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHW 146
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
FSPDG+ + + + D +I++ + ++ F + V FN G+ + S
Sbjct: 147 VRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGS 206
Query: 462 DKSINIYE 469
D+++ +++
Sbjct: 207 DQTVKVWD 214
Score = 68.1 bits (159), Expect = 6e-11
Identities = 43/182 (23%), Positives = 81/182 (44%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
F+ V ++DFS DG+ + + S I ++ + + L + +SPDG+
Sbjct: 98 FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
I S + D I I+D + V+ + F+P + + D +K++DV
Sbjct: 158 LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
L H+ V ++F P G ++ S+D T+++ DL + +T + H V+ V
Sbjct: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277
Query: 182 FN 183
F+
Sbjct: 278 FS 279
Score = 43.6 bits (98), Expect = 0.002
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 3/81 (3%)
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
HK S+ SP+G+++AT++ D + + + + + H +V VQF+ G+ L
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 458 SVSKDKSINIYECPIPPKSAK 478
S S+D+++ ++ IP K K
Sbjct: 77 SASRDRTVRLW---IPDKRGK 94
>AJ243006-1|CAB55582.1| 1205|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1205
Score = 113 bits (272), Expect = 1e-24
Identities = 105/458 (22%), Positives = 190/458 (41%), Gaps = 14/458 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + K N + + + +
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQEDMEV 799
Query: 192 VSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + S D + N + +W+ ++ + GH V V SPDG +
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLWNTDSR--SKVADCRGHLSWVHGVMFSPDGSSFLTS 857
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK 310
K + +VF + V H ++ + G +D
Sbjct: 858 SDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 915
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKT 370
+ + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 916 LTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWRIQFTADE 972
Query: 371 KLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 973 KTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNPRLLSWSFDGTVKVWNIIT 1031
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Score = 87.4 bits (207), Expect = 1e-16
Identities = 84/395 (21%), Positives = 162/395 (41%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ + KV D R
Sbjct: 780 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWN--TDSRSKVADCR 836
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 894
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 895 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 953 FQSRFQHKKTVWRIQFTADEKTLISSSDDAEIQVW 987
Score = 80.2 bits (189), Expect = 1e-14
Identities = 87/410 (21%), Positives = 168/410 (40%), Gaps = 56/410 (13%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGK-------------LVHTLEGHAMSIRSLCFSPDS 102
+SPD K +AS + DG + ++D L E + ++ +S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADG 810
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 811 ARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 869
Query: 163 SMQCQHT-----------FKEHNDQVWGVK-------FNAESNKIISVSEDK------GP 198
+ C+++ F+E+ V V N + +I ++E + P
Sbjct: 870 KV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 928
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
YI G + +++ NN++ + H+ V + + D +T+
Sbjct: 929 HLQYIAFGDENGAIEILELVNNRI--FQSRFQHKKTVWRIQFTADEKTLISSSDDAEIQV 986
Query: 259 XXXXXGQKI--REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I R Q D ++++ +P ++ + G V V+ II G +K
Sbjct: 987 WNWQLDKCIFLRGHQETVKD-FRLLKNP---RLLSWSFDGTVKVWNIITGNKEKDFVCHQ 1042
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
++S S D +S + + ++ LH + H VR AFS + LLA+
Sbjct: 1043 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1102
Query: 377 SNDGYVNVYNIESAAL---------QNKLDHKCWAVSVCFSPDGQRMATS 417
++G + ++N+ + L + H W +CFSPDG+ + ++
Sbjct: 1103 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1152
Score = 70.9 bits (166), Expect = 9e-12
Identities = 67/283 (23%), Positives = 120/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWRIQFTADEKTLISSSDDAEIQV 986
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ + +LL + S DG +K+++++ N H
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNPRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1103
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1153
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1154 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1196
Score = 69.7 bits (163), Expect = 2e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 847 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 902
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 903 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 959
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + +++
Sbjct: 960 KKTVWRIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETV-------KDFRLL- 1010
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
K P +++ D VKVW+ E H+ V+S +S D +
Sbjct: 1011 ----KNPR---LLSWSFDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1061
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1062 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1121
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1122 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1179
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1180 IHVSPDFKTYVTVDNLGILYI 1200
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 48.8 bits (111), Expect = 4e-05
Identities = 37/187 (19%), Positives = 81/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWRIQFTADEKTLISSSDDAEIQV 986
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ +LL S S DG V V+NI + + + H+
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNPRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1105 NGEIRIW 1111
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1136 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1193
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1194 NL-GILYILQTLE 1205
>AJ243007-1|CAB55583.1| 1205|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1205
Score = 113 bits (271), Expect = 2e-24
Identities = 105/458 (22%), Positives = 189/458 (41%), Gaps = 14/458 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTFQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + K N + + + +
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQEDMEV 799
Query: 192 VSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + S D + N + +W+ ++ + GH V V SPDG +
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLWNTDSR--SKVADCRGHLSWVHGVMFSPDGSSFLTS 857
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK 310
K + +VF + V H ++ + G +D
Sbjct: 858 SDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 915
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKT 370
+ + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 916 LTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 972
Query: 371 KLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 973 KTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1031
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Score = 86.6 bits (205), Expect = 2e-16
Identities = 84/395 (21%), Positives = 161/395 (40%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D +++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTFQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ + KV D R
Sbjct: 780 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWN--TDSRSKVADCR 836
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 894
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 895 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 953 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 987
Score = 79.4 bits (187), Expect = 3e-14
Identities = 87/410 (21%), Positives = 164/410 (40%), Gaps = 56/410 (13%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGK-------------LVHTLEGHAMSIRSLCFSPDS 102
+SPD K +AS + DG + ++D L E + ++ +S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADG 810
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 811 ARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 869
Query: 163 SMQCQHT-----------FKEHNDQVWGVK-------FNAESNKIISVSEDK------GP 198
+ C+++ F+E+ V V N + +I ++E + P
Sbjct: 870 KV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 928
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
YI G + +++ NN++ + H+ V + + D +T+
Sbjct: 929 HLQYIAFGDENGAIEILELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 259 XXXXXGQKI--REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I R Q D + S++ + G V V+ II G +K
Sbjct: 987 WNWQLDKCIFLRGHQETVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQ 1042
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
++S S D +S + + ++ LH + H VR AFS + LLA+
Sbjct: 1043 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1102
Query: 377 SNDGYVNVYNIESAAL---------QNKLDHKCWAVSVCFSPDGQRMATS 417
++G + ++N+ + L + H W +CFSPDG+ + ++
Sbjct: 1103 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1152
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1103
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1153
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1154 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1196
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 847 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 902
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 903 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 959
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 960 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1017
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1018 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1061
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1062 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1121
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1122 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1179
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1180 IHVSPDFKTYVTVDNLGILYI 1200
Score = 57.2 bits (132), Expect = 1e-07
Identities = 39/154 (25%), Positives = 71/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS + +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYHACFSEDGQRIASCGADKTFQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1105 NGEIRIW 1111
Score = 40.7 bits (91), Expect = 0.011
Identities = 25/88 (28%), Positives = 39/88 (44%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD + +V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTFQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1136 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1193
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1194 NL-GILYILQTLE 1205
>AJ243011-1|CAB55587.1| 1205|Homo sapiens protease activating factor-1
protein.
Length = 1205
Score = 112 bits (269), Expect = 3e-24
Identities = 106/463 (22%), Positives = 191/463 (41%), Gaps = 14/463 (3%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++
Sbjct: 618 VYRACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAG 126
D + I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
T+ GH + V FSPD K S SAD T+++WD S + K N + + +
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQ 794
Query: 187 NKIISVSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
+ + + S D + N + +W+ + + GH V V SPDG
Sbjct: 795 EDMGVIVKCCSWSADGARIMVAAKNKIFLWN--TDLRSKVADCRGHLSWVHGVMFSPDGS 852
Query: 246 TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIIN 305
+ K + +VF + V H ++ +
Sbjct: 853 SFLTSSDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRT 910
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G +D + + + + SP +YIA G E G++ + ++ ++ + H + V +
Sbjct: 911 GQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 967
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
F+ K L S+S+D + V+N + H+ V R+ + + DG+++V
Sbjct: 968 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKV 1026
Query: 426 VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ F H V + D +K S S DK+ I+
Sbjct: 1027 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Score = 87.0 bits (206), Expect = 1e-16
Identities = 84/395 (21%), Positives = 161/395 (40%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYRACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ KV D R
Sbjct: 780 SINVKQFFLNLEDPQEDMGVIVKCCSWSADGARIMVAA-KNKIFLWN--TDLRSKVADCR 836
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 894
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 895 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 953 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 987
Score = 79.0 bits (186), Expect = 3e-14
Identities = 87/410 (21%), Positives = 164/410 (40%), Gaps = 56/410 (13%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGK-------------LVHTLEGHAMSIRSLCFSPDS 102
+SPD K +AS + DG + ++D L E + ++ +S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMGVIVKCCSWSADG 810
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 811 ARIMVAAKN-KIFLWNTDLRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 869
Query: 163 SMQCQHT-----------FKEHNDQVWGVK-------FNAESNKIISVSEDK------GP 198
+ C+++ F+E+ V V N + +I ++E + P
Sbjct: 870 KV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 928
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
YI G + +++ NN++ + H+ V + + D +T+
Sbjct: 929 HLQYIAFGDENGAIEILELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 259 XXXXXGQKI--REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I R Q D + S++ + G V V+ II G +K
Sbjct: 987 WNWQLDKCIFLRGHQETVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQ 1042
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
++S S D +S + + ++ LH + H VR AFS + LLA+
Sbjct: 1043 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1102
Query: 377 SNDGYVNVYNIESAAL---------QNKLDHKCWAVSVCFSPDGQRMATS 417
++G + ++N+ + L + H W +CFSPDG+ + ++
Sbjct: 1103 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1152
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1103
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1153
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1154 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1196
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 847 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 902
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 903 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 959
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 960 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1017
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1018 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1061
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1062 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1121
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1122 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1179
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1180 IHVSPDFKTYVTVDNLGILYI 1200
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYRACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1105 NGEIRIW 1111
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYRACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1136 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1193
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1194 NL-GILYILQTLE 1205
>AJ243010-1|CAB55586.1| 1205|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1205
Score = 112 bits (269), Expect = 3e-24
Identities = 104/458 (22%), Positives = 189/458 (41%), Gaps = 14/458 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ FSPD K S SAD T+++WD S + K N + + + +
Sbjct: 743 TNSANHCRFSPDDKLLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQEDMEV 799
Query: 192 VSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + S D + N + +W+ ++ + GH V V SPDG +
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLWNTDSR--SKVADCRGHLSWVHGVMFSPDGSSFLTS 857
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK 310
K + +VF + V H ++ + G +D
Sbjct: 858 SDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 915
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKT 370
+ + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 916 LTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 972
Query: 371 KLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 973 KTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1031
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Score = 85.8 bits (203), Expect = 3e-16
Identities = 83/395 (21%), Positives = 161/395 (40%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSANHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ + KV D R
Sbjct: 780 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWN--TDSRSKVADCR 836
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 894
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 895 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 953 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 987
Score = 79.4 bits (187), Expect = 3e-14
Identities = 87/410 (21%), Positives = 164/410 (40%), Gaps = 56/410 (13%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGK-------------LVHTLEGHAMSIRSLCFSPDS 102
+SPD K +AS + DG + ++D L E + ++ +S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADG 810
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 811 ARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 869
Query: 163 SMQCQHT-----------FKEHNDQVWGVK-------FNAESNKIISVSEDK------GP 198
+ C+++ F+E+ V V N + +I ++E + P
Sbjct: 870 KV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 928
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
YI G + +++ NN++ + H+ V + + D +T+
Sbjct: 929 HLQYIAFGDENGAIEILELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 259 XXXXXGQKI--REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I R Q D + S++ + G V V+ II G +K
Sbjct: 987 WNWQLDKCIFLRGHQETVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQ 1042
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
++S S D +S + + ++ LH + H VR AFS + LLA+
Sbjct: 1043 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1102
Query: 377 SNDGYVNVYNIESAAL---------QNKLDHKCWAVSVCFSPDGQRMATS 417
++G + ++N+ + L + H W +CFSPDG+ + ++
Sbjct: 1103 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1152
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1103
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1153
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1154 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1196
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 847 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 902
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 903 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 959
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 960 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1017
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1018 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1061
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1062 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1121
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1122 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1179
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1180 IHVSPDFKTYVTVDNLGILYI 1200
Score = 56.4 bits (130), Expect = 2e-07
Identities = 38/154 (24%), Positives = 71/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSANHCRFSPDDKLLASCSADGTLKLWD 771
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1105 NGEIRIW 1111
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1136 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1193
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1194 NL-GILYILQTLE 1205
>AJ243008-1|CAB55584.1| 1205|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1205
Score = 110 bits (265), Expect = 9e-24
Identities = 104/458 (22%), Positives = 189/458 (41%), Gaps = 14/458 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ G
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGR 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + K N + + + +
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATS---ANERKSINVKQFFLNLEDPQEDMEV 799
Query: 192 VSEDKGPSKDYI-VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXX 250
+ + S D + N + +W+ ++ + GH V V SPDG +
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLWNTDSR--SKVADCRGHLSWVHGVMFSPDGSSFLTS 857
Query: 251 XXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK 310
K + +VF + V H ++ + G +D
Sbjct: 858 SDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 915
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKT 370
+ + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 916 LTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 972
Query: 371 KLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 973 KTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1031
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1032 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Score = 84.2 bits (199), Expect = 9e-16
Identities = 83/395 (21%), Positives = 161/395 (40%), Gaps = 36/395 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ G V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGRTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
I + DM IV +S DG+++ K+ ++ + KV D R
Sbjct: 780 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWN--TDSRSKVADCR 836
Query: 316 G--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G ++ V +SPDG + ++ ++ L++ K+ + + F ++
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 894
Query: 374 ASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ + + + N + + + + C SP Q +A +G+I ++ L R+
Sbjct: 895 LAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPHLQYIAFGDENGAIEILELVNNRI 952
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ +H V +QF AD L+S S D I ++
Sbjct: 953 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 987
Score = 79.4 bits (187), Expect = 3e-14
Identities = 87/410 (21%), Positives = 164/410 (40%), Gaps = 56/410 (13%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGK-------------LVHTLEGHAMSIRSLCFSPDS 102
+SPD K +AS + DG + ++D L E + ++ +S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADG 810
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
++ + + + L++ + GH SWV V FSPDG F++ S D+T+R+W+
Sbjct: 811 ARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 869
Query: 163 SMQCQHT-----------FKEHNDQVWGVK-------FNAESNKIISVSEDK------GP 198
+ C+++ F+E+ V V N + +I ++E + P
Sbjct: 870 KV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 928
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
YI G + +++ NN++ + H+ V + + D +T+
Sbjct: 929 HLQYIAFGDENGAIEILELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 259 XXXXXGQKI--REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
+ I R Q D + S++ + G V V+ II G +K
Sbjct: 987 WNWQLDKCIFLRGHQETVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQ 1042
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
++S S D +S + + ++ LH + H VR AFS + LLA+
Sbjct: 1043 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1102
Query: 377 SNDGYVNVYNIESAAL---------QNKLDHKCWAVSVCFSPDGQRMATS 417
++G + ++N+ + L + H W +CFSPDG+ + ++
Sbjct: 1103 DDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1152
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1103
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1153
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1154 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1196
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 847 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 902
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 903 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 959
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 960 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1017
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1018 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1061
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1062 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1121
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1122 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1179
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1180 IHVSPDFKTYVTVDNLGILYI 1200
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 927 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 986
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 987 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1044
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1045 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1104
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1105 NGEIRIW 1111
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1136 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1193
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1194 NL-GILYILQTLE 1205
>U82756-1|AAC02261.1| 520|Homo sapiens WD splicing factor Hprp4p
protein.
Length = 520
Score = 109 bits (261), Expect = 3e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 284 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 340
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 341 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 399
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L GH + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 400 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 459
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 460 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 504
Query: 247 IA 248
IA
Sbjct: 505 IA 506
Score = 89.0 bits (211), Expect = 3e-17
Identities = 70/292 (23%), Positives = 125/292 (42%), Gaps = 10/292 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN + K S +VS D P
Sbjct: 237 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTK----KEQLHSIPKSTVSLD--PK 290
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 291 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 348
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 349 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 408
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI AH V + F P L + +
Sbjct: 409 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY 468
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
D ++ + L+ H+ + + S DGQ +AT + D + ++ + E
Sbjct: 469 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 520
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LEGH I +
Sbjct: 353 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 412
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 413 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 472
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 473 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 512
Score = 70.9 bits (166), Expect = 9e-12
Identities = 66/287 (22%), Positives = 115/287 (40%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH L P S + L D
Sbjct: 237 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTKKEQLHSIPKSTVSLDPKDVNLAS 296
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 297 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 356
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 357 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 400
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LEGH + + SP+G IA + + I + + + F P G
Sbjct: 401 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 460
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 461 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 507
Score = 69.3 bits (162), Expect = 3e-11
Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 366 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSG 425
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 426 DNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 485
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L+GH V+ + S DG+ + S DRT ++W
Sbjct: 486 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 517
Score = 66.5 bits (155), Expect = 2e-10
Identities = 52/213 (24%), Positives = 98/213 (46%), Gaps = 8/213 (3%)
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--S 321
G ++ Q S + P +A+ G V ++ + + + V D G +
Sbjct: 269 GHNTKKEQLHSIPKSTVSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVAR 326
Query: 322 VAWSPDGRYIASGAEGGSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDG 380
V W P GR++ + S L+D+ +Q ++LH E H+ V +AF L + D
Sbjct: 327 VMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDA 385
Query: 381 YVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE 439
+ V+++ + L+ H + FSP+G +AT + D + +V L + R ++T
Sbjct: 386 FGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPA 445
Query: 440 HTHIVCGVQFN-ADGSKLVSVSKDKSINIYECP 471
H ++V GV+F G+ L++ + D + I+ P
Sbjct: 446 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHP 478
Score = 52.4 bits (120), Expect = 3e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 1 MFETG-LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP- 58
MF G L +++ ++FSP+G H+ +GS ++ + + + V + P
Sbjct: 399 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 458
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G ++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 459 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 517
>CR457105-1|CAG33386.1| 521|Homo sapiens PRPF4 protein.
Length = 521
Score = 109 bits (261), Expect = 3e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 285 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 341
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 342 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 400
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L GH + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 401 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 460
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 461 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 505
Query: 247 IA 248
IA
Sbjct: 506 IA 507
Score = 94.7 bits (225), Expect = 6e-19
Identities = 70/288 (24%), Positives = 126/288 (43%), Gaps = 10/288 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN V + F+ +S +VS D P
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLD--PK 291
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 292 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 349
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 350 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 409
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI AH V + F P L + +
Sbjct: 410 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY 469
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
D ++ + L+ H+ + + S DGQ +AT + D + ++
Sbjct: 470 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKL 517
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LEGH I +
Sbjct: 354 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 413
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 414 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 473
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 474 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 513
Score = 77.0 bits (181), Expect = 1e-13
Identities = 66/287 (22%), Positives = 119/287 (41%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH ++ ++ F P S + L D
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 357
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 358 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 401
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LEGH + + SP+G IA + + I + + + F P G
Sbjct: 402 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 461
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 462 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 508
Score = 70.1 bits (164), Expect = 2e-11
Identities = 42/155 (27%), Positives = 76/155 (49%), Gaps = 1/155 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 367 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSG 426
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 427 DNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 486
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
L+GH V+ + S DG+ + S DRT ++W D
Sbjct: 487 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAD 521
Score = 64.9 bits (151), Expect = 6e-10
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 8/197 (4%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--SVAWSPDGRYIASGAEG 337
+ P +A+ G V ++ + + + V D G + V W P GR++ +
Sbjct: 286 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYD 343
Query: 338 GSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S L+D+ +Q ++LH E H+ V +AF L + D + V+++ + L
Sbjct: 344 RSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 402
Query: 397 D-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFN-ADGS 454
+ H + FSP+G +AT + D + +V L + R ++T H ++V GV+F G+
Sbjct: 403 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 462
Query: 455 KLVSVSKDKSINIYECP 471
L++ + D + I+ P
Sbjct: 463 FLLTGAYDNTAKIWTHP 479
Score = 52.4 bits (120), Expect = 3e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 1 MFETG-LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP- 58
MF G L +++ ++FSP+G H+ +GS ++ + + + V + P
Sbjct: 400 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 459
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G ++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 460 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Score = 38.7 bits (86), Expect = 0.045
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ--------RMAT 416
FSP +K+LA+A G ++++ L + L H ++ F P +A+
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
AADGS+++ L+ + E HT V V ++ G L + D+S +++
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
>BC007424-1|AAH07424.1| 521|Homo sapiens PRP4 pre-mRNA processing
factor 4 homolog (yeast) protein.
Length = 521
Score = 109 bits (261), Expect = 3e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 285 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 341
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 342 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 400
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L GH + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 401 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 460
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 461 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 505
Query: 247 IA 248
IA
Sbjct: 506 IA 507
Score = 95.9 bits (228), Expect = 3e-19
Identities = 71/292 (24%), Positives = 128/292 (43%), Gaps = 10/292 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN V + F+ +S +VS D P
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLD--PK 291
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 292 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 349
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 350 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 409
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI AH V + F P L + +
Sbjct: 410 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY 469
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
D ++ + L+ H+ + + S DGQ +AT + D + ++ + E
Sbjct: 470 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 521
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LEGH I +
Sbjct: 354 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 413
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 414 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 473
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 474 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 513
Score = 77.0 bits (181), Expect = 1e-13
Identities = 66/287 (22%), Positives = 119/287 (41%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH ++ ++ F P S + L D
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 357
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 358 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 401
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LEGH + + SP+G IA + + I + + + F P G
Sbjct: 402 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 461
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 462 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 367 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSG 426
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 427 DNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 486
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L+GH V+ + S DG+ + S DRT ++W
Sbjct: 487 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Score = 64.9 bits (151), Expect = 6e-10
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 8/197 (4%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--SVAWSPDGRYIASGAEG 337
+ P +A+ G V ++ + + + V D G + V W P GR++ +
Sbjct: 286 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYD 343
Query: 338 GSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S L+D+ +Q ++LH E H+ V +AF L + D + V+++ + L
Sbjct: 344 RSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 402
Query: 397 D-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFN-ADGS 454
+ H + FSP+G +AT + D + +V L + R ++T H ++V GV+F G+
Sbjct: 403 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 462
Query: 455 KLVSVSKDKSINIYECP 471
L++ + D + I+ P
Sbjct: 463 FLLTGAYDNTAKIWTHP 479
Score = 52.4 bits (120), Expect = 3e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 1 MFETG-LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP- 58
MF G L +++ ++FSP+G H+ +GS ++ + + + V + P
Sbjct: 400 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 459
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G ++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 460 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Score = 38.7 bits (86), Expect = 0.045
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ--------RMAT 416
FSP +K+LA+A G ++++ L + L H ++ F P +A+
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
AADGS+++ L+ + E HT V V ++ G L + D+S +++
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
>BC001588-1|AAH01588.1| 522|Homo sapiens PRP4 pre-mRNA processing
factor 4 homolog (yeast) protein.
Length = 522
Score = 109 bits (261), Expect = 3e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 342
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 343 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 401
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L GH + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 402 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 461
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 462 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 506
Query: 247 IA 248
IA
Sbjct: 507 IA 508
Score = 95.9 bits (228), Expect = 3e-19
Identities = 71/292 (24%), Positives = 128/292 (43%), Gaps = 10/292 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN V + F+ +S +VS D P
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLD--PK 292
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 293 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 350
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 351 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI AH V + F P L + +
Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY 470
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
D ++ + L+ H+ + + S DGQ +AT + D + ++ + E
Sbjct: 471 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LEGH I +
Sbjct: 355 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 414
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 474
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 475 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 514
Score = 77.0 bits (181), Expect = 1e-13
Identities = 66/287 (22%), Positives = 119/287 (41%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH ++ ++ F P S + L D
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 359 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 402
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LEGH + + SP+G IA + + I + + + F P G
Sbjct: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 462
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 463 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 509
Score = 69.3 bits (162), Expect = 3e-11
Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 368 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSG 427
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 428 DNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 487
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L+GH V+ + S DG+ + S DRT ++W
Sbjct: 488 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 64.9 bits (151), Expect = 6e-10
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 8/197 (4%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--SVAWSPDGRYIASGAEG 337
+ P +A+ G V ++ + + + V D G + V W P GR++ +
Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYD 344
Query: 338 GSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S L+D+ +Q ++LH E H+ V +AF L + D + V+++ + L
Sbjct: 345 RSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 403
Query: 397 D-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFN-ADGS 454
+ H + FSP+G +AT + D + +V L + R ++T H ++V GV+F G+
Sbjct: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463
Query: 455 KLVSVSKDKSINIYECP 471
L++ + D + I+ P
Sbjct: 464 FLLTGAYDNTAKIWTHP 480
Score = 52.4 bits (120), Expect = 3e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 1 MFETG-LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP- 58
MF G L +++ ++FSP+G H+ +GS ++ + + + V + P
Sbjct: 401 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 460
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G ++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 461 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 38.7 bits (86), Expect = 0.045
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ--------RMAT 416
FSP +K+LA+A G ++++ L + L H ++ F P +A+
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
AADGS+++ L+ + E HT V V ++ G L + D+S +++
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 351
>AY572489-1|AAS78572.1| 521|Homo sapiens 60 kDa U4/U6
snRNP-specific spliceosomal protein protein.
Length = 521
Score = 109 bits (261), Expect = 3e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 285 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 341
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 342 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 400
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L GH + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 401 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 460
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 461 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 505
Query: 247 IA 248
IA
Sbjct: 506 IA 507
Score = 95.9 bits (228), Expect = 3e-19
Identities = 71/292 (24%), Positives = 128/292 (43%), Gaps = 10/292 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN V + F+ +S +VS D P
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLD--PK 291
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 292 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 349
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 350 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 409
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI AH V + F P L + +
Sbjct: 410 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY 469
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
D ++ + L+ H+ + + S DGQ +AT + D + ++ + E
Sbjct: 470 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 521
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LEGH I +
Sbjct: 354 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 413
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 414 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 473
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 474 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 513
Score = 77.0 bits (181), Expect = 1e-13
Identities = 66/287 (22%), Positives = 119/287 (41%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH ++ ++ F P S + L D
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 357
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 358 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 401
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LEGH + + SP+G IA + + I + + + F P G
Sbjct: 402 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 461
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 462 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 367 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSG 426
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 427 DNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 486
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L+GH V+ + S DG+ + S DRT ++W
Sbjct: 487 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Score = 64.9 bits (151), Expect = 6e-10
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 8/197 (4%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--SVAWSPDGRYIASGAEG 337
+ P +A+ G V ++ + + + V D G + V W P GR++ +
Sbjct: 286 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYD 343
Query: 338 GSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S L+D+ +Q ++LH E H+ V +AF L + D + V+++ + L
Sbjct: 344 RSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 402
Query: 397 D-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFN-ADGS 454
+ H + FSP+G +AT + D + +V L + R ++T H ++V GV+F G+
Sbjct: 403 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 462
Query: 455 KLVSVSKDKSINIYECP 471
L++ + D + I+ P
Sbjct: 463 FLLTGAYDNTAKIWTHP 479
Score = 52.4 bits (120), Expect = 3e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 1 MFETG-LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP- 58
MF G L +++ ++FSP+G H+ +GS ++ + + + V + P
Sbjct: 400 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 459
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G ++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 460 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Score = 38.7 bits (86), Expect = 0.045
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ--------RMAT 416
FSP +K+LA+A G ++++ L + L H ++ F P +A+
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
AADGS+++ L+ + E HT V V ++ G L + D+S +++
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
>AL449305-8|CAI10969.1| 521|Homo sapiens PRP4 pre-mRNA processing
factor 4 homolog (yeast) protein.
Length = 521
Score = 109 bits (261), Expect = 3e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 285 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 341
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 342 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 400
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L GH + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 401 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 460
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 461 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 505
Query: 247 IA 248
IA
Sbjct: 506 IA 507
Score = 95.9 bits (228), Expect = 3e-19
Identities = 71/292 (24%), Positives = 128/292 (43%), Gaps = 10/292 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN V + F+ +S +VS D P
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLD--PK 291
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 292 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 349
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 350 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 409
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI AH V + F P L + +
Sbjct: 410 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY 469
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
D ++ + L+ H+ + + S DGQ +AT + D + ++ + E
Sbjct: 470 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 521
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LEGH I +
Sbjct: 354 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 413
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 414 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 473
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 474 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 513
Score = 77.0 bits (181), Expect = 1e-13
Identities = 66/287 (22%), Positives = 119/287 (41%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH ++ ++ F P S + L D
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 357
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 358 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 401
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LEGH + + SP+G IA + + I + + + F P G
Sbjct: 402 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 461
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 462 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 508
Score = 69.3 bits (162), Expect = 3e-11
Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 367 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSG 426
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 427 DNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 486
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L+GH V+ + S DG+ + S DRT ++W
Sbjct: 487 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Score = 64.9 bits (151), Expect = 6e-10
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 8/197 (4%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--SVAWSPDGRYIASGAEG 337
+ P +A+ G V ++ + + + V D G + V W P GR++ +
Sbjct: 286 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYD 343
Query: 338 GSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S L+D+ +Q ++LH E H+ V +AF L + D + V+++ + L
Sbjct: 344 RSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 402
Query: 397 D-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFN-ADGS 454
+ H + FSP+G +AT + D + +V L + R ++T H ++V GV+F G+
Sbjct: 403 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 462
Query: 455 KLVSVSKDKSINIYECP 471
L++ + D + I+ P
Sbjct: 463 FLLTGAYDNTAKIWTHP 479
Score = 52.4 bits (120), Expect = 3e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 1 MFETG-LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP- 58
MF G L +++ ++FSP+G H+ +GS ++ + + + V + P
Sbjct: 400 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 459
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G ++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 460 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Score = 38.7 bits (86), Expect = 0.045
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ--------RMAT 416
FSP +K+LA+A G ++++ L + L H ++ F P +A+
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
AADGS+++ L+ + E HT V V ++ G L + D+S +++
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
>AL449305-7|CAI10968.1| 522|Homo sapiens PRP4 pre-mRNA processing
factor 4 homolog (yeast) protein.
Length = 522
Score = 109 bits (261), Expect = 3e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 342
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 343 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 401
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L GH + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 402 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 461
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 462 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 506
Query: 247 IA 248
IA
Sbjct: 507 IA 508
Score = 95.9 bits (228), Expect = 3e-19
Identities = 71/292 (24%), Positives = 128/292 (43%), Gaps = 10/292 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN V + F+ +S +VS D P
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLD--PK 292
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 293 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 350
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 351 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI AH V + F P L + +
Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY 470
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
D ++ + L+ H+ + + S DGQ +AT + D + ++ + E
Sbjct: 471 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LEGH I +
Sbjct: 355 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 414
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 474
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 475 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 514
Score = 77.0 bits (181), Expect = 1e-13
Identities = 66/287 (22%), Positives = 119/287 (41%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH ++ ++ F P S + L D
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 359 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 402
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LEGH + + SP+G IA + + I + + + F P G
Sbjct: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 462
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 463 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 509
Score = 69.3 bits (162), Expect = 3e-11
Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 368 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSG 427
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 428 DNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 487
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L+GH V+ + S DG+ + S DRT ++W
Sbjct: 488 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 64.9 bits (151), Expect = 6e-10
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 8/197 (4%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--SVAWSPDGRYIASGAEG 337
+ P +A+ G V ++ + + + V D G + V W P GR++ +
Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYD 344
Query: 338 GSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S L+D+ +Q ++LH E H+ V +AF L + D + V+++ + L
Sbjct: 345 RSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 403
Query: 397 D-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFN-ADGS 454
+ H + FSP+G +AT + D + +V L + R ++T H ++V GV+F G+
Sbjct: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463
Query: 455 KLVSVSKDKSINIYECP 471
L++ + D + I+ P
Sbjct: 464 FLLTGAYDNTAKIWTHP 480
Score = 52.4 bits (120), Expect = 3e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 1 MFETG-LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP- 58
MF G L +++ ++FSP+G H+ +GS ++ + + + V + P
Sbjct: 401 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 460
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G ++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 461 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 38.7 bits (86), Expect = 0.045
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ--------RMAT 416
FSP +K+LA+A G ++++ L + L H ++ F P +A+
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
AADGS+++ L+ + E HT V V ++ G L + D+S +++
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 351
>AF016369-1|AAC51925.1| 522|Homo sapiens U4/U6 small nuclear
ribonucleoprotein hPrp4 protein.
Length = 522
Score = 109 bits (261), Expect = 3e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 342
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 343 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 401
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L GH + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 402 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 461
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 462 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 506
Query: 247 IA 248
IA
Sbjct: 507 IA 508
Score = 95.9 bits (228), Expect = 3e-19
Identities = 71/292 (24%), Positives = 128/292 (43%), Gaps = 10/292 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN V + F+ +S +VS D P
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLD--PK 292
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 293 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 350
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 351 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI AH V + F P L + +
Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY 470
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
D ++ + L+ H+ + + S DGQ +AT + D + ++ + E
Sbjct: 471 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LEGH I +
Sbjct: 355 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 414
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 415 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 474
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 475 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 514
Score = 77.0 bits (181), Expect = 1e-13
Identities = 66/287 (22%), Positives = 119/287 (41%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH ++ ++ F P S + L D
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 359 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 402
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LEGH + + SP+G IA + + I + + + F P G
Sbjct: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 462
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 463 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 509
Score = 69.3 bits (162), Expect = 3e-11
Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 368 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSG 427
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 428 DNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 487
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L+GH V+ + S DG+ + S DRT ++W
Sbjct: 488 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 64.9 bits (151), Expect = 6e-10
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 8/197 (4%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--SVAWSPDGRYIASGAEG 337
+ P +A+ G V ++ + + + V D G + V W P GR++ +
Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYD 344
Query: 338 GSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S L+D+ +Q ++LH E H+ V +AF L + D + V+++ + L
Sbjct: 345 RSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 403
Query: 397 D-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFN-ADGS 454
+ H + FSP+G +AT + D + +V L + R ++T H ++V GV+F G+
Sbjct: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463
Query: 455 KLVSVSKDKSINIYECP 471
L++ + D + I+ P
Sbjct: 464 FLLTGAYDNTAKIWTHP 480
Score = 52.4 bits (120), Expect = 3e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 1 MFETG-LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP- 58
MF G L +++ ++FSP+G H+ +GS ++ + + + V + P
Sbjct: 401 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 460
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G ++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 461 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 38.7 bits (86), Expect = 0.045
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ--------RMAT 416
FSP +K+LA+A G ++++ L + L H ++ F P +A+
Sbjct: 239 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
AADGS+++ L+ + E HT V V ++ G L + D+S +++
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 351
>AB209797-1|BAD93034.1| 537|Homo sapiens PRPF4 protein variant
protein.
Length = 537
Score = 109 bits (261), Expect = 3e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 301 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 357
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 358 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 416
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L GH + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 417 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 476
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 477 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 521
Query: 247 IA 248
IA
Sbjct: 522 IA 523
Score = 95.9 bits (228), Expect = 3e-19
Identities = 71/292 (24%), Positives = 128/292 (43%), Gaps = 10/292 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN V + F+ +S +VS D P
Sbjct: 254 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLD--PK 307
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 308 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 365
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 366 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 425
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI AH V + F P L + +
Sbjct: 426 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAY 485
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
D ++ + L+ H+ + + S DGQ +AT + D + ++ + E
Sbjct: 486 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 537
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LEGH I +
Sbjct: 370 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 429
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 430 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 489
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 490 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 529
Score = 77.0 bits (181), Expect = 1e-13
Identities = 66/287 (22%), Positives = 119/287 (41%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH ++ ++ F P S + L D
Sbjct: 254 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 313
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 314 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 373
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 374 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 417
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LEGH + + SP+G IA + + I + + + F P G
Sbjct: 418 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG 477
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 478 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 524
Score = 69.3 bits (162), Expect = 3e-11
Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 383 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSG 442
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 443 DNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 502
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L+GH V+ + S DG+ + S DRT ++W
Sbjct: 503 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 534
Score = 64.9 bits (151), Expect = 6e-10
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 8/197 (4%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--SVAWSPDGRYIASGAEG 337
+ P +A+ G V ++ + + + V D G + V W P GR++ +
Sbjct: 302 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYD 359
Query: 338 GSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S L+D+ +Q ++LH E H+ V +AF L + D + V+++ + L
Sbjct: 360 RSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 418
Query: 397 D-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFN-ADGS 454
+ H + FSP+G +AT + D + +V L + R ++T H ++V GV+F G+
Sbjct: 419 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 478
Query: 455 KLVSVSKDKSINIYECP 471
L++ + D + I+ P
Sbjct: 479 FLLTGAYDNTAKIWTHP 495
Score = 52.4 bits (120), Expect = 3e-06
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 1 MFETG-LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP- 58
MF G L +++ ++FSP+G H+ +GS ++ + + + V + P
Sbjct: 416 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 475
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G ++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 476 HGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 534
Score = 38.7 bits (86), Expect = 0.045
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ--------RMAT 416
FSP +K+LA+A G ++++ L + L H ++ F P +A+
Sbjct: 254 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 313
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
AADGS+++ L+ + E HT V V ++ G L + D+S +++
Sbjct: 314 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 366
>AK127882-1|BAC87175.1| 369|Homo sapiens protein ( Homo sapiens
cDNA FLJ45988 fis, clone PUAEN2006639, weakly similar
to Vegetatible incompatibility protein HET-E-1. ).
Length = 369
Score = 108 bits (260), Expect = 4e-23
Identities = 69/232 (29%), Positives = 112/232 (48%), Gaps = 17/232 (7%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYS-PDGKYIASGALDGIINIFD 76
G I+GS ++ SG++ L+ ++A++ P G IA+G+ D ++
Sbjct: 104 GSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWS 163
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V GK HT GH I L F+P S L+ TGS D KL+D+ + TL GH++ ++
Sbjct: 164 VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEII 223
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
S++F+ G R ++GS D TV VWD D+ + + H ++ FN + +
Sbjct: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--------- 274
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
I+TG +D K+W N K + TL GH+ ++ G+ IA
Sbjct: 275 -----LILTGSMDKTCKLWDATNGK--CVATLTGHDDEILDSCFDYTGKLIA 319
Score = 101 bits (242), Expect = 6e-21
Identities = 70/281 (24%), Positives = 122/281 (43%), Gaps = 20/281 (7%)
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L H + +VA + G F++GS DRT ++WD S + +T + H + V+ + FN
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFN---- 143
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
P D I TG D K+WS E K HT GH +V ++ +P +
Sbjct: 144 ---------NPYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNPQSTLV 192
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT 307
A G+++ ++ S+++ + F+ G ++ TG V V+ G
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
Query: 308 VDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
+L I S +++ D I +G+ + L+D + GK + T+ H + F
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD 312
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFS 408
KL+A+AS D V++ +A+ + W + C S
Sbjct: 313 YTGKLIATASADDGVSLCRPGRSAVA-----RSWLTATCAS 348
Score = 100 bits (239), Expect = 1e-20
Identities = 62/262 (23%), Positives = 114/262 (43%), Gaps = 17/262 (6%)
Query: 82 LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF- 140
L L+ H + + ++ + +TGS D KL+D TL GH + V ++AF
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFN 143
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G + +GS D+T ++W +++ +C HTF+ H ++ + FN P
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN--------------PQS 189
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
+ TG +D K+W +N E ++TL GH ++S++ + G+ I
Sbjct: 190 TLVATGSMDTTAKLWDIQNG--EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G+K+ + +++ F+ D S + TG ++ NG L I+
Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEIL 307
Query: 321 SVAWSPDGRYIASGAEGGSVYL 342
+ G+ IA+ + V L
Sbjct: 308 DSCFDYTGKLIATASADDGVSL 329
Score = 96.3 bits (229), Expect = 2e-19
Identities = 52/192 (27%), Positives = 97/192 (50%), Gaps = 1/192 (0%)
Query: 9 VWTLDFS-PDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
V+ + F+ P G + +GS ++ VE+GK + ++++P +A+G+
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D ++D+ G+ V+TL GH+ I SL F+ ++TGS D + ++D
Sbjct: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNI 256
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L GH + + S +F+ D ++GS D+T ++WD + +C T H+D++ F+
Sbjct: 257 LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316
Query: 188 KIISVSEDKGPS 199
I + S D G S
Sbjct: 317 LIATASADDGVS 328
Score = 83.8 bits (198), Expect = 1e-15
Identities = 57/240 (23%), Positives = 105/240 (43%), Gaps = 17/240 (7%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDD 111
+VA + G +G+ D ++D A G+ ++TLEGH + ++ F +P + TGS D
Sbjct: 97 NVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFD 156
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
KL+ V T GH + ++ ++F+P +GS D T ++WD+ + + +T +
Sbjct: 157 KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGH 231
H+ ++ + FN S D I+TG D+ V VW + + ++ L GH
Sbjct: 217 GHSAEIISLSFNT--------------SGDRIITGSFDHTVVVWDADTGR--KVNILIGH 260
Query: 232 EMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
+ S + + D I G+ + + ++ F G +AT
Sbjct: 261 CAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIAT 320
Score = 81.0 bits (191), Expect = 8e-15
Identities = 44/152 (28%), Positives = 74/152 (48%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
F ++ L F+P V +GS ++ +++G++ L +S++++ G
Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
I +G+ D + ++D G+ V+ L GH I S F+ D L+LTGS D KL+D +
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSAD 153
TL+GH +L F GK + SAD
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASAD 324
Score = 69.3 bits (162), Expect = 3e-11
Identities = 45/192 (23%), Positives = 91/192 (47%), Gaps = 2/192 (1%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWS-PDGRYIASGAEGG 338
+ + GS TG + ++ +G L+ + ++A++ P G IA+G+
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDK 157
Query: 339 SVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-D 397
+ L+ V GK HT H + L+F+P++ L+A+ S D +++I++ L
Sbjct: 158 TCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG 217
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
H +S+ F+ G R+ T + D ++ V + R ++ H + FN D S ++
Sbjct: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLIL 277
Query: 458 SVSKDKSINIYE 469
+ S DK+ +++
Sbjct: 278 TGSMDKTCKLWD 289
Score = 60.5 bits (140), Expect = 1e-08
Identities = 36/162 (22%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAF-SP 368
KVL + +VA + G +G+ + L+D + G+ L+T+E H V ++AF +P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNNP 145
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
+A+ S D ++++E+ + H V + F+P +AT + D + ++
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ ++T H+ + + FN G ++++ S D ++ +++
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Score = 56.4 bits (130), Expect = 2e-07
Identities = 30/106 (28%), Positives = 55/106 (51%), Gaps = 1/106 (0%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
++ +L F+ G +I+GS ++++ ++G++ +L S +++ D I +G+
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGS-DDG 112
+D ++D GK V TL GH I CF +L+ T S DDG
Sbjct: 281 MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADDG 326
Score = 41.9 bits (94), Expect = 0.005
Identities = 28/123 (22%), Positives = 60/123 (48%), Gaps = 4/123 (3%)
Query: 350 MLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFS 408
+ ++AH + ++A + + S D +++ S N L+ H+ ++ F+
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFN 143
Query: 409 -PDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT-HIVCGVQFNADGSKLVSVSKDKSIN 466
P G ++AT + D + ++ +E + HTF HT IVC + FN + + + S D +
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVC-LSFNPQSTLVATGSMDTTAK 202
Query: 467 IYE 469
+++
Sbjct: 203 LWD 205
>X95525-1|CAA64777.1| 799|Homo sapiens hTAFII100 protein.
Length = 799
Score = 107 bits (258), Expect = 6e-23
Identities = 52/152 (34%), Positives = 79/152 (51%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
VW FSP G + +SG + ++ + + ++ + P+ Y+A+G+
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++DV G V GH I SL FSP+ + L TG+ DG + L+D+ H + G L
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
GH V S+ FS DG+ SGS D TVR+WD
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 94.7 bits (225), Expect = 6e-19
Identities = 75/283 (26%), Positives = 113/283 (39%), Gaps = 16/283 (5%)
Query: 31 LIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHA 90
LI G + +V K SV + D I + D + I D + L GH+
Sbjct: 484 LIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHS 543
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSG 150
+ FSPD LL+ S+DG ++L+ + GH V FSP G FVSG
Sbjct: 544 GPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSG 603
Query: 151 SADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDN 210
DR R+W D Q F H V +F+ P+ +Y+ TG D
Sbjct: 604 GHDRVARLWATDHYQPLRIFAGHLADVNCTRFH--------------PNSNYVATGSADR 649
Query: 211 LVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREI 270
V++W N + T GH+ P+ S+ SP+G +A G + E+
Sbjct: 650 TVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 271 QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLD 313
+ + + + FS DG +A+G V ++ I D D
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETD 750
Score = 89.4 bits (212), Expect = 2e-17
Identities = 53/189 (28%), Positives = 89/189 (47%), Gaps = 2/189 (1%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P ++Y+++ D V++WS + L +GH PV SP G
Sbjct: 553 PDRNYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 610
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
Q +R +D+ F P+ + VATG V ++ ++NG ++
Sbjct: 611 LWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG 670
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
I S+ +SP+GR++A+GA G V L+D+ G M+ ++ H V SL FS ++LAS S
Sbjct: 671 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGS 730
Query: 378 NDGYVNVYN 386
D V +++
Sbjct: 731 MDNTVRLWD 739
Score = 87.0 bits (206), Expect = 1e-16
Identities = 48/187 (25%), Positives = 86/187 (45%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ FSPD +++S S G + ++ +++ +SP G Y SG
Sbjct: 546 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGH 605
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ + + GH + F P+S + TGS D ++L+DV++ N
Sbjct: 606 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 665
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
+GH + S+ FSP+G+ +G+ D V +WD+ K H D V ++F+ +
Sbjct: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI 725
Query: 189 IISVSED 195
+ S S D
Sbjct: 726 LASGSMD 732
Score = 74.9 bits (176), Expect = 6e-13
Identities = 48/202 (23%), Positives = 86/202 (42%), Gaps = 1/202 (0%)
Query: 225 LHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP 284
L L GH PV + SPD + + + + +W FSP
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
G +GGH ++ + ++ + + P+ Y+A+G+ +V L+D
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAV 403
V G + H + SL FSP + LA+ + DG V +++I + +L H
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 404 SVCFSPDGQRMATSAADGSIRV 425
S+ FS DG+ +A+ + D ++R+
Sbjct: 716 SLRFSRDGEILASGSMDNTVRL 737
Score = 74.9 bits (176), Expect = 6e-13
Identities = 38/122 (31%), Positives = 70/122 (57%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F L DV F P+ +V +GS + ++ V +G ++ S+ +SP+G
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG 681
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+++A+GA DG + ++D+ G +V L+GH ++ SL FS D ++L +GS D ++L+D +
Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Query: 121 HA 122
A
Sbjct: 742 KA 743
Score = 71.3 bits (167), Expect = 7e-12
Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 15/269 (5%)
Query: 203 IVTGGL-DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
++ GG D+ V+VWS KL SV + D I
Sbjct: 484 LIAGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKESDDVLERIMDE 530
Query: 262 XXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMS 321
+++ + S ++ FSPD + + + G V ++ + T +
Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 590
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+SP G Y SG L+ + L H V F P + +A+ S D
Sbjct: 591 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 650
Query: 382 VNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
V ++++ + ++ HK S+ FSP+G+ +AT A DG + + + ++ + H
Sbjct: 651 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 710
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIYE 469
T VC ++F+ DG L S S D ++ +++
Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>U80191-1|AAC51215.1| 800|Homo sapiens TFIID subunit TAFII100
protein.
Length = 800
Score = 107 bits (258), Expect = 6e-23
Identities = 52/152 (34%), Positives = 79/152 (51%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
VW FSP G + +SG + ++ + + ++ + P+ Y+A+G+
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++DV G V GH I SL FSP+ + L TG+ DG + L+D+ H + G L
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
GH V S+ FS DG+ SGS D TVR+WD
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 94.7 bits (225), Expect = 6e-19
Identities = 75/283 (26%), Positives = 113/283 (39%), Gaps = 16/283 (5%)
Query: 31 LIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHA 90
LI G + +V K SV + D I + D + I D + L GH+
Sbjct: 484 LIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHS 543
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSG 150
+ FSPD LL+ S+DG ++L+ + GH V FSP G FVSG
Sbjct: 544 GPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSG 603
Query: 151 SADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDN 210
DR R+W D Q F H V +F+ P+ +Y+ TG D
Sbjct: 604 GHDRVARLWATDHYQPLRIFAGHLADVNCTRFH--------------PNSNYVATGSADR 649
Query: 211 LVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREI 270
V++W N + T GH+ P+ S+ SP+G +A G + E+
Sbjct: 650 TVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 271 QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLD 313
+ + + + FS DG +A+G V ++ I D D
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETD 750
Score = 89.4 bits (212), Expect = 2e-17
Identities = 53/189 (28%), Positives = 89/189 (47%), Gaps = 2/189 (1%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P ++Y+++ D V++WS + L +GH PV SP G
Sbjct: 553 PDRNYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 610
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
Q +R +D+ F P+ + VATG V ++ ++NG ++
Sbjct: 611 LWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG 670
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
I S+ +SP+GR++A+GA G V L+D+ G M+ ++ H V SL FS ++LAS S
Sbjct: 671 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGS 730
Query: 378 NDGYVNVYN 386
D V +++
Sbjct: 731 MDNTVRLWD 739
Score = 87.0 bits (206), Expect = 1e-16
Identities = 48/187 (25%), Positives = 86/187 (45%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ FSPD +++S S G + ++ +++ +SP G Y SG
Sbjct: 546 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGH 605
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ + + GH + F P+S + TGS D ++L+DV++ N
Sbjct: 606 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 665
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
+GH + S+ FSP+G+ +G+ D V +WD+ K H D V ++F+ +
Sbjct: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI 725
Query: 189 IISVSED 195
+ S S D
Sbjct: 726 LASGSMD 732
Score = 74.9 bits (176), Expect = 6e-13
Identities = 48/202 (23%), Positives = 86/202 (42%), Gaps = 1/202 (0%)
Query: 225 LHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP 284
L L GH PV + SPD + + + + +W FSP
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
G +GGH ++ + ++ + + P+ Y+A+G+ +V L+D
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAV 403
V G + H + SL FSP + LA+ + DG V +++I + +L H
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 404 SVCFSPDGQRMATSAADGSIRV 425
S+ FS DG+ +A+ + D ++R+
Sbjct: 716 SLRFSRDGEILASGSMDNTVRL 737
Score = 74.9 bits (176), Expect = 6e-13
Identities = 38/122 (31%), Positives = 70/122 (57%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F L DV F P+ +V +GS + ++ V +G ++ S+ +SP+G
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG 681
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+++A+GA DG + ++D+ G +V L+GH ++ SL FS D ++L +GS D ++L+D +
Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Query: 121 HA 122
A
Sbjct: 742 KA 743
Score = 71.3 bits (167), Expect = 7e-12
Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 15/269 (5%)
Query: 203 IVTGGL-DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
++ GG D+ V+VWS KL SV + D I
Sbjct: 484 LIAGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKESDDVLERIMDE 530
Query: 262 XXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMS 321
+++ + S ++ FSPD + + + G V ++ + T +
Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 590
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+SP G Y SG L+ + L H V F P + +A+ S D
Sbjct: 591 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 650
Query: 382 VNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
V ++++ + ++ HK S+ FSP+G+ +AT A DG + + + ++ + H
Sbjct: 651 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 710
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIYE 469
T VC ++F+ DG L S S D ++ +++
Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>U75309-1|AAC50902.1| 801|Homo sapiens TBP-associated factor
protein.
Length = 801
Score = 107 bits (258), Expect = 6e-23
Identities = 52/152 (34%), Positives = 79/152 (51%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
VW FSP G + +SG + ++ + + ++ + P+ Y+A+G+
Sbjct: 589 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 648
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++DV G V GH I SL FSP+ + L TG+ DG + L+D+ H + G L
Sbjct: 649 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 708
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
GH V S+ FS DG+ SGS D TVR+WD
Sbjct: 709 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 740
Score = 94.7 bits (225), Expect = 6e-19
Identities = 75/283 (26%), Positives = 113/283 (39%), Gaps = 16/283 (5%)
Query: 31 LIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHA 90
LI G + +V K SV + D I + D + I D + L GH+
Sbjct: 485 LIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHS 544
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSG 150
+ FSPD LL+ S+DG ++L+ + GH V FSP G FVSG
Sbjct: 545 GPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSG 604
Query: 151 SADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDN 210
DR R+W D Q F H V +F+ P+ +Y+ TG D
Sbjct: 605 GHDRVARLWATDHYQPLRIFAGHLADVNCTRFH--------------PNSNYVATGSADR 650
Query: 211 LVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREI 270
V++W N + T GH+ P+ S+ SP+G +A G + E+
Sbjct: 651 TVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 708
Query: 271 QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLD 313
+ + + + FS DG +A+G V ++ I D D
Sbjct: 709 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETD 751
Score = 89.4 bits (212), Expect = 2e-17
Identities = 53/189 (28%), Positives = 89/189 (47%), Gaps = 2/189 (1%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P ++Y+++ D V++WS + L +GH PV SP G
Sbjct: 554 PDRNYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 611
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
Q +R +D+ F P+ + VATG V ++ ++NG ++
Sbjct: 612 LWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG 671
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
I S+ +SP+GR++A+GA G V L+D+ G M+ ++ H V SL FS ++LAS S
Sbjct: 672 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGS 731
Query: 378 NDGYVNVYN 386
D V +++
Sbjct: 732 MDNTVRLWD 740
Score = 87.0 bits (206), Expect = 1e-16
Identities = 48/187 (25%), Positives = 86/187 (45%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ FSPD +++S S G + ++ +++ +SP G Y SG
Sbjct: 547 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGH 606
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ + + GH + F P+S + TGS D ++L+DV++ N
Sbjct: 607 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 666
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
+GH + S+ FSP+G+ +G+ D V +WD+ K H D V ++F+ +
Sbjct: 667 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI 726
Query: 189 IISVSED 195
+ S S D
Sbjct: 727 LASGSMD 733
Score = 74.9 bits (176), Expect = 6e-13
Identities = 48/202 (23%), Positives = 86/202 (42%), Gaps = 1/202 (0%)
Query: 225 LHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP 284
L L GH PV + SPD + + + + +W FSP
Sbjct: 537 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 596
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
G +GGH ++ + ++ + + P+ Y+A+G+ +V L+D
Sbjct: 597 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 656
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAV 403
V G + H + SL FSP + LA+ + DG V +++I + +L H
Sbjct: 657 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 716
Query: 404 SVCFSPDGQRMATSAADGSIRV 425
S+ FS DG+ +A+ + D ++R+
Sbjct: 717 SLRFSRDGEILASGSMDNTVRL 738
Score = 74.9 bits (176), Expect = 6e-13
Identities = 38/122 (31%), Positives = 70/122 (57%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F L DV F P+ +V +GS + ++ V +G ++ S+ +SP+G
Sbjct: 623 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG 682
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+++A+GA DG + ++D+ G +V L+GH ++ SL FS D ++L +GS D ++L+D +
Sbjct: 683 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 742
Query: 121 HA 122
A
Sbjct: 743 KA 744
Score = 71.3 bits (167), Expect = 7e-12
Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 15/269 (5%)
Query: 203 IVTGGL-DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
++ GG D+ V+VWS KL SV + D I
Sbjct: 485 LIAGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKESDDVLERIMDE 531
Query: 262 XXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMS 321
+++ + S ++ FSPD + + + G V ++ + T +
Sbjct: 532 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 591
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+SP G Y SG L+ + L H V F P + +A+ S D
Sbjct: 592 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 651
Query: 382 VNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
V ++++ + ++ HK S+ FSP+G+ +AT A DG + + + ++ + H
Sbjct: 652 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 711
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIYE 469
T VC ++F+ DG L S S D ++ +++
Sbjct: 712 TDTVCSLRFSRDGEILASGSMDNTVRLWD 740
>BC052268-1|AAH52268.2| 800|Homo sapiens TAF5 RNA polymerase II,
TATA box binding protein (TBP)-associated factor, 100kD
protein.
Length = 800
Score = 107 bits (258), Expect = 6e-23
Identities = 52/152 (34%), Positives = 79/152 (51%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
VW FSP G + +SG + ++ + + ++ + P+ Y+A+G+
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++DV G V GH I SL FSP+ + L TG+ DG + L+D+ H + G L
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
GH V S+ FS DG+ SGS D TVR+WD
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 94.7 bits (225), Expect = 6e-19
Identities = 75/283 (26%), Positives = 113/283 (39%), Gaps = 16/283 (5%)
Query: 31 LIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHA 90
LI G + +V K SV + D I + D + I D + L GH+
Sbjct: 484 LIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHS 543
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSG 150
+ FSPD LL+ S+DG ++L+ + GH V FSP G FVSG
Sbjct: 544 GPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSG 603
Query: 151 SADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDN 210
DR R+W D Q F H V +F+ P+ +Y+ TG D
Sbjct: 604 GHDRVARLWATDHYQPLRIFAGHLADVNCTRFH--------------PNSNYVATGSADR 649
Query: 211 LVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREI 270
V++W N + T GH+ P+ S+ SP+G +A G + E+
Sbjct: 650 TVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 271 QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLD 313
+ + + + FS DG +A+G V ++ I D D
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETD 750
Score = 89.4 bits (212), Expect = 2e-17
Identities = 53/189 (28%), Positives = 89/189 (47%), Gaps = 2/189 (1%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P ++Y+++ D V++WS + L +GH PV SP G
Sbjct: 553 PDRNYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 610
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
Q +R +D+ F P+ + VATG V ++ ++NG ++
Sbjct: 611 LWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG 670
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
I S+ +SP+GR++A+GA G V L+D+ G M+ ++ H V SL FS ++LAS S
Sbjct: 671 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGS 730
Query: 378 NDGYVNVYN 386
D V +++
Sbjct: 731 MDNTVRLWD 739
Score = 87.0 bits (206), Expect = 1e-16
Identities = 48/187 (25%), Positives = 86/187 (45%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ FSPD +++S S G + ++ +++ +SP G Y SG
Sbjct: 546 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGH 605
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ + + GH + F P+S + TGS D ++L+DV++ N
Sbjct: 606 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 665
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
+GH + S+ FSP+G+ +G+ D V +WD+ K H D V ++F+ +
Sbjct: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI 725
Query: 189 IISVSED 195
+ S S D
Sbjct: 726 LASGSMD 732
Score = 74.9 bits (176), Expect = 6e-13
Identities = 48/202 (23%), Positives = 86/202 (42%), Gaps = 1/202 (0%)
Query: 225 LHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP 284
L L GH PV + SPD + + + + +W FSP
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
G +GGH ++ + ++ + + P+ Y+A+G+ +V L+D
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAV 403
V G + H + SL FSP + LA+ + DG V +++I + +L H
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 404 SVCFSPDGQRMATSAADGSIRV 425
S+ FS DG+ +A+ + D ++R+
Sbjct: 716 SLRFSRDGEILASGSMDNTVRL 737
Score = 74.9 bits (176), Expect = 6e-13
Identities = 38/122 (31%), Positives = 70/122 (57%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F L DV F P+ +V +GS + ++ V +G ++ S+ +SP+G
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG 681
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+++A+GA DG + ++D+ G +V L+GH ++ SL FS D ++L +GS D ++L+D +
Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Query: 121 HA 122
A
Sbjct: 742 KA 743
Score = 71.3 bits (167), Expect = 7e-12
Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 15/269 (5%)
Query: 203 IVTGGL-DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
++ GG D+ V+VWS KL SV + D I
Sbjct: 484 LIAGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKESDDVLERIMDE 530
Query: 262 XXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMS 321
+++ + S ++ FSPD + + + G V ++ + T +
Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 590
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+SP G Y SG L+ + L H V F P + +A+ S D
Sbjct: 591 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 650
Query: 382 VNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
V ++++ + ++ HK S+ FSP+G+ +AT A DG + + + ++ + H
Sbjct: 651 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 710
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIYE 469
T VC ++F+ DG L S S D ++ +++
Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>AL591408-4|CAI16747.1| 800|Homo sapiens TAF5 RNA polymerase II,
TATA box binding protein (TBP)-associated factor, 100kD
protein.
Length = 800
Score = 107 bits (258), Expect = 6e-23
Identities = 52/152 (34%), Positives = 79/152 (51%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
VW FSP G + +SG + ++ + + ++ + P+ Y+A+G+
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++DV G V GH I SL FSP+ + L TG+ DG + L+D+ H + G L
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
GH V S+ FS DG+ SGS D TVR+WD
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 94.7 bits (225), Expect = 6e-19
Identities = 75/283 (26%), Positives = 113/283 (39%), Gaps = 16/283 (5%)
Query: 31 LIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHA 90
LI G + +V K SV + D I + D + I D + L GH+
Sbjct: 484 LIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHS 543
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSG 150
+ FSPD LL+ S+DG ++L+ + GH V FSP G FVSG
Sbjct: 544 GPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSG 603
Query: 151 SADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDN 210
DR R+W D Q F H V +F+ P+ +Y+ TG D
Sbjct: 604 GHDRVARLWATDHYQPLRIFAGHLADVNCTRFH--------------PNSNYVATGSADR 649
Query: 211 LVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREI 270
V++W N + T GH+ P+ S+ SP+G +A G + E+
Sbjct: 650 TVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 271 QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLD 313
+ + + + FS DG +A+G V ++ I D D
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETD 750
Score = 89.4 bits (212), Expect = 2e-17
Identities = 53/189 (28%), Positives = 89/189 (47%), Gaps = 2/189 (1%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P ++Y+++ D V++WS + L +GH PV SP G
Sbjct: 553 PDRNYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 610
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
Q +R +D+ F P+ + VATG V ++ ++NG ++
Sbjct: 611 LWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG 670
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
I S+ +SP+GR++A+GA G V L+D+ G M+ ++ H V SL FS ++LAS S
Sbjct: 671 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGS 730
Query: 378 NDGYVNVYN 386
D V +++
Sbjct: 731 MDNTVRLWD 739
Score = 87.0 bits (206), Expect = 1e-16
Identities = 48/187 (25%), Positives = 86/187 (45%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ FSPD +++S S G + ++ +++ +SP G Y SG
Sbjct: 546 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGH 605
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ + + GH + F P+S + TGS D ++L+DV++ N
Sbjct: 606 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 665
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
+GH + S+ FSP+G+ +G+ D V +WD+ K H D V ++F+ +
Sbjct: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI 725
Query: 189 IISVSED 195
+ S S D
Sbjct: 726 LASGSMD 732
Score = 74.9 bits (176), Expect = 6e-13
Identities = 48/202 (23%), Positives = 86/202 (42%), Gaps = 1/202 (0%)
Query: 225 LHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP 284
L L GH PV + SPD + + + + +W FSP
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
G +GGH ++ + ++ + + P+ Y+A+G+ +V L+D
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAV 403
V G + H + SL FSP + LA+ + DG V +++I + +L H
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 404 SVCFSPDGQRMATSAADGSIRV 425
S+ FS DG+ +A+ + D ++R+
Sbjct: 716 SLRFSRDGEILASGSMDNTVRL 737
Score = 74.9 bits (176), Expect = 6e-13
Identities = 38/122 (31%), Positives = 70/122 (57%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F L DV F P+ +V +GS + ++ V +G ++ S+ +SP+G
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG 681
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+++A+GA DG + ++D+ G +V L+GH ++ SL FS D ++L +GS D ++L+D +
Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Query: 121 HA 122
A
Sbjct: 742 KA 743
Score = 71.3 bits (167), Expect = 7e-12
Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 15/269 (5%)
Query: 203 IVTGGL-DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
++ GG D+ V+VWS KL SV + D I
Sbjct: 484 LIAGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKESDDVLERIMDE 530
Query: 262 XXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMS 321
+++ + S ++ FSPD + + + G V ++ + T +
Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 590
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+SP G Y SG L+ + L H V F P + +A+ S D
Sbjct: 591 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 650
Query: 382 VNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
V ++++ + ++ HK S+ FSP+G+ +AT A DG + + + ++ + H
Sbjct: 651 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 710
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIYE 469
T VC ++F+ DG L S S D ++ +++
Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>AK223615-1|BAD97335.1| 803|Homo sapiens Transcription initiation
factor TFIID subunit 5 variant protein.
Length = 803
Score = 107 bits (258), Expect = 6e-23
Identities = 52/152 (34%), Positives = 79/152 (51%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
VW FSP G + +SG + ++ + + ++ + P+ Y+A+G+
Sbjct: 591 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 650
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++DV G V GH I SL FSP+ + L TG+ DG + L+D+ H + G L
Sbjct: 651 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 710
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
GH V S+ FS DG+ SGS D TVR+WD
Sbjct: 711 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 742
Score = 94.7 bits (225), Expect = 6e-19
Identities = 75/283 (26%), Positives = 113/283 (39%), Gaps = 16/283 (5%)
Query: 31 LIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHA 90
LI G + +V K SV + D I + D + I D + L GH+
Sbjct: 487 LIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHS 546
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSG 150
+ FSPD LL+ S+DG ++L+ + GH V FSP G FVSG
Sbjct: 547 GPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSG 606
Query: 151 SADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDN 210
DR R+W D Q F H V +F+ P+ +Y+ TG D
Sbjct: 607 GHDRVARLWATDHYQPLRIFAGHLADVNCTRFH--------------PNSNYVATGSADR 652
Query: 211 LVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREI 270
V++W N + T GH+ P+ S+ SP+G +A G + E+
Sbjct: 653 TVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 710
Query: 271 QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLD 313
+ + + + FS DG +A+G V ++ I D D
Sbjct: 711 KGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETD 753
Score = 89.4 bits (212), Expect = 2e-17
Identities = 53/189 (28%), Positives = 89/189 (47%), Gaps = 2/189 (1%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P ++Y+++ D V++WS + L +GH PV SP G
Sbjct: 556 PDRNYLLSSSEDGTVRLWSLQT--FTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 613
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
Q +R +D+ F P+ + VATG V ++ ++NG ++
Sbjct: 614 LWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG 673
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
I S+ +SP+GR++A+GA G V L+D+ G M+ ++ H V SL FS ++LAS S
Sbjct: 674 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGS 733
Query: 378 NDGYVNVYN 386
D V +++
Sbjct: 734 MDNTVRLWD 742
Score = 87.0 bits (206), Expect = 1e-16
Identities = 48/187 (25%), Positives = 86/187 (45%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ FSPD +++S S G + ++ +++ +SP G Y SG
Sbjct: 549 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGH 608
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ + + GH + F P+S + TGS D ++L+DV++ N
Sbjct: 609 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 668
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
+GH + S+ FSP+G+ +G+ D V +WD+ K H D V ++F+ +
Sbjct: 669 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI 728
Query: 189 IISVSED 195
+ S S D
Sbjct: 729 LASGSMD 735
Score = 74.9 bits (176), Expect = 6e-13
Identities = 48/202 (23%), Positives = 86/202 (42%), Gaps = 1/202 (0%)
Query: 225 LHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP 284
L L GH PV + SPD + + + + +W FSP
Sbjct: 539 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 598
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
G +GGH ++ + ++ + + P+ Y+A+G+ +V L+D
Sbjct: 599 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 658
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAV 403
V G + H + SL FSP + LA+ + DG V +++I + +L H
Sbjct: 659 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 718
Query: 404 SVCFSPDGQRMATSAADGSIRV 425
S+ FS DG+ +A+ + D ++R+
Sbjct: 719 SLRFSRDGEILASGSMDNTVRL 740
Score = 74.9 bits (176), Expect = 6e-13
Identities = 38/122 (31%), Positives = 70/122 (57%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F L DV F P+ +V +GS + ++ V +G ++ S+ +SP+G
Sbjct: 625 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG 684
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+++A+GA DG + ++D+ G +V L+GH ++ SL FS D ++L +GS D ++L+D +
Sbjct: 685 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 744
Query: 121 HA 122
A
Sbjct: 745 KA 746
Score = 71.3 bits (167), Expect = 7e-12
Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 15/269 (5%)
Query: 203 IVTGGL-DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
++ GG D+ V+VWS KL SV + D I
Sbjct: 487 LIAGGFADSTVRVWSVTPKKLR-------------SVKQASDLSLIDKESDDVLERIMDE 533
Query: 262 XXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMS 321
+++ + S ++ FSPD + + + G V ++ + T +
Sbjct: 534 KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD 593
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+SP G Y SG L+ + L H V F P + +A+ S D
Sbjct: 594 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 653
Query: 382 VNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
V ++++ + ++ HK S+ FSP+G+ +AT A DG + + + ++ + H
Sbjct: 654 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 713
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIYE 469
T VC ++F+ DG L S S D ++ +++
Sbjct: 714 TDTVCSLRFSRDGEILASGSMDNTVRLWD 742
>AF001687-1|AAB87640.1| 521|Homo sapiens U4/U6 snRNP 60 kDa protein
protein.
Length = 521
Score = 106 bits (254), Expect = 2e-22
Identities = 70/242 (28%), Positives = 117/242 (48%), Gaps = 23/242 (9%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA---YSPDGKYIASGA 67
T+ P ++ S + G + ++ ++S E V D G T+ VA + P G+++ +
Sbjct: 285 TVSLDPKDVNLASCAADGSVKLWSLDS--DEPVADIEGH-TVRVARVMWHPSGRFLGTTC 341
Query: 68 LDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
D ++D+ AQ +++H EGH+M + + F D L TG D +++D+
Sbjct: 342 YDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM 400
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
L H + + FSP+G +GS D T +VWDL +C +T H + V GVKF
Sbjct: 401 FLEDHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPPHQNLVTGVKFEPIH 460
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
++++TG DN K+W++ L TL GHE V+ + +S DG+
Sbjct: 461 G-------------NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQL 505
Query: 247 IA 248
IA
Sbjct: 506 IA 507
Score = 95.9 bits (228), Expect = 3e-19
Identities = 71/292 (24%), Positives = 128/292 (43%), Gaps = 10/292 (3%)
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
FSP+ K + ++W + HT + HN V + F+ +S +VS D P
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKS----TVSLD--PK 291
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+ + D VK+WS +++ E + +EGH + V V P G +
Sbjct: 292 DVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 349
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFI 319
++I + S ++ I F DGS TGG V+ + G L+ K I
Sbjct: 350 DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEDHLKEI 409
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP-KTKLLASASN 378
+ +SP+G +IA+G+ + ++D+ Q + ++TI H V + F P L + +
Sbjct: 410 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPPHQNLVTGVKFEPIHGNFLLTGAY 469
Query: 379 DGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
D ++ + L+ H+ + + S DGQ +AT + D + ++ +LE
Sbjct: 470 DNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATYSYDRTFKLWMLE 521
Score = 77.4 bits (182), Expect = 1e-13
Identities = 43/160 (26%), Positives = 73/160 (45%), Gaps = 3/160 (1%)
Query: 40 QEQVLDTRGKF--TLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
QE++L G +A+ DG +G LD ++D+ G+ + LE H I +
Sbjct: 354 QEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEDHLKEIYGIN 413
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSP-DGKRFVSGSADRTV 156
FSP+ + TGS D K++D+ T+ H + V V F P G ++G+ D T
Sbjct: 414 FSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPPHQNLVTGVKFEPIHGNFLLTGAYDNTA 473
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
++W T H +V G+ +++ I + S D+
Sbjct: 474 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATYSYDR 513
Score = 73.7 bits (173), Expect = 1e-12
Identities = 65/287 (22%), Positives = 118/287 (41%), Gaps = 25/287 (8%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSD----- 110
+SP+ K +A+ G+ ++ V L+HTL GH ++ ++ F P S + L D
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 111 ---DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
DG +KL+ + + GH V V + P G+ + DR+ R+WDL++ +
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 357
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
+ H+ V+ + F+ + + TGGLD +VW + +
Sbjct: 358 LHQEGHSMGVYDIAFHQDGS--------------LAGTGGLDAFGRVWDLRTGRCIMF-- 401
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSP-DG 286
LE H + + SP+G IA + + I + + + F P G
Sbjct: 402 LEDHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPPHQNLVTGVKFEPIHG 461
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
+ + TG + ++ + K L +M + S DG+ IA+
Sbjct: 462 NFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 508
Score = 70.1 bits (164), Expect = 2e-11
Identities = 42/155 (27%), Positives = 77/155 (49%), Gaps = 1/155 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + F DG +G ++ + +G+ L+ K + +SP+G +IA+G+
Sbjct: 367 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEDHLKEIYGINFSPNGYHIATGSG 426
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGT 127
D ++D+ Q + V+T+ H + + F P LLTG+ D K++ + T
Sbjct: 427 DNTCKVWDLRQRRCVYTIPPHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKT 486
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
L+GH V+ + S DG+ + S DRT ++W L+
Sbjct: 487 LAGHEGKVMGLDISSDGQLIATYSYDRTFKLWMLE 521
Score = 66.5 bits (155), Expect = 2e-10
Identities = 50/197 (25%), Positives = 93/197 (47%), Gaps = 8/197 (4%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM--SVAWSPDGRYIASGAEG 337
+ P +A+ G V ++ + + + V D G + V W P GR++ +
Sbjct: 286 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCYD 343
Query: 338 GSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
S L+D+ +Q ++LH E H+ V +AF L + D + V+++ + L
Sbjct: 344 RSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 402
Query: 397 -DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFN-ADGS 454
DH + FSP+G +AT + D + +V L + R ++T H ++V GV+F G+
Sbjct: 403 EDHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPPHQNLVTGVKFEPIHGN 462
Query: 455 KLVSVSKDKSINIYECP 471
L++ + D + I+ P
Sbjct: 463 FLLTGAYDNTAKIWTHP 479
Score = 52.0 bits (119), Expect = 4e-06
Identities = 30/116 (25%), Positives = 52/116 (44%), Gaps = 1/116 (0%)
Query: 3 ETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP-DGK 61
E L +++ ++FSP+G H+ +GS ++ + + + V + P G
Sbjct: 403 EDHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPPHQNLVTGVKFEPIHGN 462
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
++ +GA D I+ + TL GH + L S D QL+ T S D KL+
Sbjct: 463 FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATYSYDRTFKLW 518
Score = 38.7 bits (86), Expect = 0.045
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 9/113 (7%)
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ--------RMAT 416
FSP +K+LA+A G ++++ L + L H ++ F P +A+
Sbjct: 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 297
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
AADGS+++ L+ + E HT V V ++ G L + D+S +++
Sbjct: 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
>EF079890-1|ABN48555.1| 444|Homo sapiens ATG16 autophagy related
16-like protein 1 protein.
Length = 444
Score = 103 bits (248), Expect = 1e-21
Identities = 83/309 (26%), Positives = 138/309 (44%), Gaps = 29/309 (9%)
Query: 43 VLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVH--TLEGHAMSIRSLCFSP 100
V D +V +SP + +A+G +D + +++V K +L G I S+ F
Sbjct: 154 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 213
Query: 101 DSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
LL S+D +++ V L TL+GH+ VLS F D R VSGS DRT+++WD
Sbjct: 214 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWD 273
Query: 161 LDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYEN- 219
L S C T V + N I+ ++ +++G D ++ W +
Sbjct: 274 LRSKVCIKT----------VFAGSSCNDIVC-------TEQCVMSGHFDKKIRFWDIRSE 316
Query: 220 ---NKLELLHTLEGHEM-PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSS 275
++ELL + ++ P + +S + + + S
Sbjct: 317 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFK----CGS 372
Query: 276 DMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR-GKFIMSVAWSPDGRYIASG 334
D ++VFSPDGS VA G G + ++ ++ G V+KVL + I +VAWSP G ++ S
Sbjct: 373 DWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSV 432
Query: 335 AEGGSVYLF 343
+G L+
Sbjct: 433 DKGCKAVLW 441
Score = 62.9 bits (146), Expect = 2e-09
Identities = 57/286 (19%), Positives = 117/286 (40%), Gaps = 12/286 (4%)
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
F+A ++ +V P + TGG+D VK+W K E +L G + S+
Sbjct: 155 FDAHDGEVNAVQFS--PGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFD 212
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
G + + + S + F D +++ +G H + ++
Sbjct: 213 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 272
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+ + K + G + + + + SG + +D+ ++ +E + +
Sbjct: 273 DLRSKVCIKTV-FAGSSCNDIVCTE--QCVMSGHFDKKIRFWDIRSESIVREMELLGK-I 328
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWA--VSVCFSPDGQRMAT 416
+L +P+ L S S D + V ++ + A++ KC + V FSPDG +A
Sbjct: 329 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 388
Query: 417 SAADGSIRVVLLEEFRVLHTF-EEHTHIVCGVQFNADGSKLVSVSK 461
+A+GS+ + + +V ++H+ + V ++ GS +VSV K
Sbjct: 389 GSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 434
Score = 53.2 bits (122), Expect = 2e-06
Identities = 30/122 (24%), Positives = 62/122 (50%), Gaps = 3/122 (2%)
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLD-HKCWAVSVCF 407
L +AH V ++ FSP ++LLA+ D V ++ + E + L S+ F
Sbjct: 152 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 211
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
G + ++ D + R+ ++++R+ HT H+ V +F D +++VS S D+++ +
Sbjct: 212 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 271
Query: 468 YE 469
++
Sbjct: 272 WD 273
Score = 52.4 bits (120), Expect = 3e-06
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 28/319 (8%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
V A H V +V FSP + +G DR V++W++ +C+ FK
Sbjct: 147 VPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCE--FKG------- 197
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ + I S+ D S Y++ D ++W+ ++ +L HTL GH V+S
Sbjct: 198 -SLSGSNAGITSIEFDSAGS--YLLAASNDFASRIWTVDDYRLR--HTLTGHSGKVLSAK 252
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGH-TGKV 298
D I I+ + SS IV + Q GH K+
Sbjct: 253 FLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS-CNDIVCT---EQCVMSGHFDKKI 308
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
+ I + ++ + ++ GK I ++ +P+ + S + + + D+ + T A
Sbjct: 309 RFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG 367
Query: 359 QAVRS----LAFSPKTKLLASASNDGYVNVYNIESAALQNKL--DHKCWAVSVCFSPDGQ 412
S + FSP +A+ S +G + ++++ + ++ L H +V +SP G
Sbjct: 368 FKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGS 427
Query: 413 RMATSAADGSIRVVLLEEF 431
+ + D + VL ++
Sbjct: 428 HVV--SVDKGCKAVLWAQY 444
Score = 47.2 bits (107), Expect = 1e-04
Identities = 24/58 (41%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 10 WT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTL-SVAYSPDGKYIAS 65
WT + FSPDG +V +GS G + I+ V +GK E+VL + ++ +VA+SP G ++ S
Sbjct: 374 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 431
Score = 45.6 bits (103), Expect = 4e-04
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS----VAYSPDGK 61
L + LD +P+ ++S S + + + + +Q G S V +SPDG
Sbjct: 325 LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGS 384
Query: 62 YIASGALDGIINIFDVAQGKLVHTL-EGHAMSIRSLCFSP 100
Y+A+G+ +G + I+ V GK+ L + H+ SI ++ +SP
Sbjct: 385 YVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSP 424
>EF079889-1|ABN48554.1| 588|Homo sapiens ATG16 autophagy related
16-like protein 1 protein.
Length = 588
Score = 103 bits (248), Expect = 1e-21
Identities = 83/309 (26%), Positives = 138/309 (44%), Gaps = 29/309 (9%)
Query: 43 VLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVH--TLEGHAMSIRSLCFSP 100
V D +V +SP + +A+G +D + +++V K +L G I S+ F
Sbjct: 298 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 357
Query: 101 DSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
LL S+D +++ V L TL+GH+ VLS F D R VSGS DRT+++WD
Sbjct: 358 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWD 417
Query: 161 LDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYEN- 219
L S C T V + N I+ ++ +++G D ++ W +
Sbjct: 418 LRSKVCIKT----------VFAGSSCNDIVC-------TEQCVMSGHFDKKIRFWDIRSE 460
Query: 220 ---NKLELLHTLEGHEM-PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSS 275
++ELL + ++ P + +S + + + S
Sbjct: 461 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFK----CGS 516
Query: 276 DMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR-GKFIMSVAWSPDGRYIASG 334
D ++VFSPDGS VA G G + ++ ++ G V+KVL + I +VAWSP G ++ S
Sbjct: 517 DWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSV 576
Query: 335 AEGGSVYLF 343
+G L+
Sbjct: 577 DKGCKAVLW 585
Score = 62.9 bits (146), Expect = 2e-09
Identities = 57/286 (19%), Positives = 117/286 (40%), Gaps = 12/286 (4%)
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
F+A ++ +V P + TGG+D VK+W K E +L G + S+
Sbjct: 299 FDAHDGEVNAVQFS--PGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFD 356
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
G + + + S + F D +++ +G H + ++
Sbjct: 357 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 416
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+ + K + G + + + + SG + +D+ ++ +E + +
Sbjct: 417 DLRSKVCIKTV-FAGSSCNDIVCTE--QCVMSGHFDKKIRFWDIRSESIVREMELLGK-I 472
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWA--VSVCFSPDGQRMAT 416
+L +P+ L S S D + V ++ + A++ KC + V FSPDG +A
Sbjct: 473 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 532
Query: 417 SAADGSIRVVLLEEFRVLHTF-EEHTHIVCGVQFNADGSKLVSVSK 461
+A+GS+ + + +V ++H+ + V ++ GS +VSV K
Sbjct: 533 GSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 578
Score = 53.2 bits (122), Expect = 2e-06
Identities = 30/122 (24%), Positives = 62/122 (50%), Gaps = 3/122 (2%)
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLD-HKCWAVSVCF 407
L +AH V ++ FSP ++LLA+ D V ++ + E + L S+ F
Sbjct: 296 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 355
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
G + ++ D + R+ ++++R+ HT H+ V +F D +++VS S D+++ +
Sbjct: 356 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 415
Query: 468 YE 469
++
Sbjct: 416 WD 417
Score = 52.4 bits (120), Expect = 3e-06
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 28/319 (8%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
V A H V +V FSP + +G DR V++W++ +C+ FK
Sbjct: 291 VPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCE--FKG------- 341
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ + I S+ D S Y++ D ++W+ ++ +L HTL GH V+S
Sbjct: 342 -SLSGSNAGITSIEFDSAGS--YLLAASNDFASRIWTVDDYRLR--HTLTGHSGKVLSAK 396
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGH-TGKV 298
D I I+ + SS IV + Q GH K+
Sbjct: 397 FLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS-CNDIVCT---EQCVMSGHFDKKI 452
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
+ I + ++ + ++ GK I ++ +P+ + S + + + D+ + T A
Sbjct: 453 RFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG 511
Query: 359 QAVRS----LAFSPKTKLLASASNDGYVNVYNIESAALQNKL--DHKCWAVSVCFSPDGQ 412
S + FSP +A+ S +G + ++++ + ++ L H +V +SP G
Sbjct: 512 FKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGS 571
Query: 413 RMATSAADGSIRVVLLEEF 431
+ + D + VL ++
Sbjct: 572 HVV--SVDKGCKAVLWAQY 588
Score = 47.2 bits (107), Expect = 1e-04
Identities = 24/58 (41%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 10 WT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTL-SVAYSPDGKYIAS 65
WT + FSPDG +V +GS G + I+ V +GK E+VL + ++ +VA+SP G ++ S
Sbjct: 518 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 575
Score = 45.6 bits (103), Expect = 4e-04
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS----VAYSPDGK 61
L + LD +P+ ++S S + + + + +Q G S V +SPDG
Sbjct: 469 LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGS 528
Query: 62 YIASGALDGIINIFDVAQGKLVHTL-EGHAMSIRSLCFSP 100
Y+A+G+ +G + I+ V GK+ L + H+ SI ++ +SP
Sbjct: 529 YVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSP 568
>BC117337-1|AAI17338.1| 523|Homo sapiens ATG16L1 protein protein.
Length = 523
Score = 103 bits (248), Expect = 1e-21
Identities = 83/309 (26%), Positives = 138/309 (44%), Gaps = 29/309 (9%)
Query: 43 VLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVH--TLEGHAMSIRSLCFSP 100
V D +V +SP + +A+G +D + +++V K +L G I S+ F
Sbjct: 233 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 292
Query: 101 DSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
LL S+D +++ V L TL+GH+ VLS F D R VSGS DRT+++WD
Sbjct: 293 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWD 352
Query: 161 LDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYEN- 219
L S C T V + N I+ ++ +++G D ++ W +
Sbjct: 353 LRSKVCIKT----------VFAGSSCNDIVC-------TEQCVMSGHFDKKIRFWDIRSE 395
Query: 220 ---NKLELLHTLEGHEM-PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSS 275
++ELL + ++ P + +S + + + S
Sbjct: 396 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFK----CGS 451
Query: 276 DMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR-GKFIMSVAWSPDGRYIASG 334
D ++VFSPDGS VA G G + ++ ++ G V+KVL + I +VAWSP G ++ S
Sbjct: 452 DWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSV 511
Query: 335 AEGGSVYLF 343
+G L+
Sbjct: 512 DKGCKAVLW 520
Score = 62.9 bits (146), Expect = 2e-09
Identities = 57/286 (19%), Positives = 117/286 (40%), Gaps = 12/286 (4%)
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
F+A ++ +V P + TGG+D VK+W K E +L G + S+
Sbjct: 234 FDAHDGEVNAVQFS--PGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFD 291
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
G + + + S + F D +++ +G H + ++
Sbjct: 292 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 351
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+ + K + G + + + + SG + +D+ ++ +E + +
Sbjct: 352 DLRSKVCIKTV-FAGSSCNDIVCTE--QCVMSGHFDKKIRFWDIRSESIVREMELLGK-I 407
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWA--VSVCFSPDGQRMAT 416
+L +P+ L S S D + V ++ + A++ KC + V FSPDG +A
Sbjct: 408 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 467
Query: 417 SAADGSIRVVLLEEFRVLHTF-EEHTHIVCGVQFNADGSKLVSVSK 461
+A+GS+ + + +V ++H+ + V ++ GS +VSV K
Sbjct: 468 GSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 513
Score = 53.2 bits (122), Expect = 2e-06
Identities = 30/122 (24%), Positives = 62/122 (50%), Gaps = 3/122 (2%)
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLD-HKCWAVSVCF 407
L +AH V ++ FSP ++LLA+ D V ++ + E + L S+ F
Sbjct: 231 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 290
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
G + ++ D + R+ ++++R+ HT H+ V +F D +++VS S D+++ +
Sbjct: 291 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 350
Query: 468 YE 469
++
Sbjct: 351 WD 352
Score = 52.4 bits (120), Expect = 3e-06
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 28/319 (8%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
V A H V +V FSP + +G DR V++W++ +C+ FK
Sbjct: 226 VPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCE--FKG------- 276
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ + I S+ D S Y++ D ++W+ ++ +L HTL GH V+S
Sbjct: 277 -SLSGSNAGITSIEFDSAGS--YLLAASNDFASRIWTVDDYRLR--HTLTGHSGKVLSAK 331
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGH-TGKV 298
D I I+ + SS IV + Q GH K+
Sbjct: 332 FLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS-CNDIVCT---EQCVMSGHFDKKI 387
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
+ I + ++ + ++ GK I ++ +P+ + S + + + D+ + T A
Sbjct: 388 RFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG 446
Query: 359 QAVRS----LAFSPKTKLLASASNDGYVNVYNIESAALQNKL--DHKCWAVSVCFSPDGQ 412
S + FSP +A+ S +G + ++++ + ++ L H +V +SP G
Sbjct: 447 FKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGS 506
Query: 413 RMATSAADGSIRVVLLEEF 431
+ + D + VL ++
Sbjct: 507 HVV--SVDKGCKAVLWAQY 523
Score = 47.2 bits (107), Expect = 1e-04
Identities = 24/58 (41%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 10 WT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTL-SVAYSPDGKYIAS 65
WT + FSPDG +V +GS G + I+ V +GK E+VL + ++ +VA+SP G ++ S
Sbjct: 453 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 510
Score = 45.6 bits (103), Expect = 4e-04
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS----VAYSPDGK 61
L + LD +P+ ++S S + + + + +Q G S V +SPDG
Sbjct: 404 LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGS 463
Query: 62 YIASGALDGIINIFDVAQGKLVHTL-EGHAMSIRSLCFSP 100
Y+A+G+ +G + I+ V GK+ L + H+ SI ++ +SP
Sbjct: 464 YVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSP 503
>BC071846-1|AAH71846.1| 475|Homo sapiens ATG16L1 protein protein.
Length = 475
Score = 103 bits (248), Expect = 1e-21
Identities = 83/309 (26%), Positives = 138/309 (44%), Gaps = 29/309 (9%)
Query: 43 VLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVH--TLEGHAMSIRSLCFSP 100
V D +V +SP + +A+G +D + +++V K +L G I S+ F
Sbjct: 185 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 244
Query: 101 DSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
LL S+D +++ V L TL+GH+ VLS F D R VSGS DRT+++WD
Sbjct: 245 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWD 304
Query: 161 LDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYEN- 219
L S C T V + N I+ ++ +++G D ++ W +
Sbjct: 305 LRSKVCIKT----------VFAGSSCNDIVC-------TEQCVMSGHFDKKIRFWDIRSE 347
Query: 220 ---NKLELLHTLEGHEM-PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSS 275
++ELL + ++ P + +S + + + S
Sbjct: 348 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFK----CGS 403
Query: 276 DMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR-GKFIMSVAWSPDGRYIASG 334
D ++VFSPDGS VA G G + ++ ++ G V+KVL + I +VAWSP G ++ S
Sbjct: 404 DWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSV 463
Query: 335 AEGGSVYLF 343
+G L+
Sbjct: 464 DKGCKAVLW 472
Score = 62.9 bits (146), Expect = 2e-09
Identities = 57/286 (19%), Positives = 117/286 (40%), Gaps = 12/286 (4%)
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
F+A ++ +V P + TGG+D VK+W K E +L G + S+
Sbjct: 186 FDAHDGEVNAVQFS--PGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFD 243
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
G + + + S + F D +++ +G H + ++
Sbjct: 244 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 303
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+ + K + G + + + + SG + +D+ ++ +E + +
Sbjct: 304 DLRSKVCIKTV-FAGSSCNDIVCTE--QCVMSGHFDKKIRFWDIRSESIVREMELLGK-I 359
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWA--VSVCFSPDGQRMAT 416
+L +P+ L S S D + V ++ + A++ KC + V FSPDG +A
Sbjct: 360 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 419
Query: 417 SAADGSIRVVLLEEFRVLHTF-EEHTHIVCGVQFNADGSKLVSVSK 461
+A+GS+ + + +V ++H+ + V ++ GS +VSV K
Sbjct: 420 GSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 465
Score = 53.2 bits (122), Expect = 2e-06
Identities = 30/122 (24%), Positives = 62/122 (50%), Gaps = 3/122 (2%)
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLD-HKCWAVSVCF 407
L +AH V ++ FSP ++LLA+ D V ++ + E + L S+ F
Sbjct: 183 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 242
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
G + ++ D + R+ ++++R+ HT H+ V +F D +++VS S D+++ +
Sbjct: 243 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 302
Query: 468 YE 469
++
Sbjct: 303 WD 304
Score = 52.4 bits (120), Expect = 3e-06
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 28/319 (8%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
V A H V +V FSP + +G DR V++W++ +C+ FK
Sbjct: 178 VPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCE--FKG------- 228
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ + I S+ D S Y++ D ++W+ ++ +L HTL GH V+S
Sbjct: 229 -SLSGSNAGITSIEFDSAGS--YLLAASNDFASRIWTVDDYRLR--HTLTGHSGKVLSAK 283
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGH-TGKV 298
D I I+ + SS IV + Q GH K+
Sbjct: 284 FLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS-CNDIVCT---EQCVMSGHFDKKI 339
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
+ I + ++ + ++ GK I ++ +P+ + S + + + D+ + T A
Sbjct: 340 RFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG 398
Query: 359 QAVRS----LAFSPKTKLLASASNDGYVNVYNIESAALQNKL--DHKCWAVSVCFSPDGQ 412
S + FSP +A+ S +G + ++++ + ++ L H +V +SP G
Sbjct: 399 FKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGS 458
Query: 413 RMATSAADGSIRVVLLEEF 431
+ + D + VL ++
Sbjct: 459 HVV--SVDKGCKAVLWAQY 475
Score = 47.2 bits (107), Expect = 1e-04
Identities = 24/58 (41%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 10 WT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTL-SVAYSPDGKYIAS 65
WT + FSPDG +V +GS G + I+ V +GK E+VL + ++ +VA+SP G ++ S
Sbjct: 405 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 462
Score = 45.6 bits (103), Expect = 4e-04
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS----VAYSPDGK 61
L + LD +P+ ++S S + + + + +Q G S V +SPDG
Sbjct: 356 LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGS 415
Query: 62 YIASGALDGIINIFDVAQGKLVHTL-EGHAMSIRSLCFSP 100
Y+A+G+ +G + I+ V GK+ L + H+ SI ++ +SP
Sbjct: 416 YVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSP 455
>AY398617-1|AAR32130.1| 607|Homo sapiens APG16L beta protein.
Length = 607
Score = 103 bits (248), Expect = 1e-21
Identities = 83/309 (26%), Positives = 138/309 (44%), Gaps = 29/309 (9%)
Query: 43 VLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVH--TLEGHAMSIRSLCFSP 100
V D +V +SP + +A+G +D + +++V K +L G I S+ F
Sbjct: 317 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 376
Query: 101 DSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
LL S+D +++ V L TL+GH+ VLS F D R VSGS DRT+++WD
Sbjct: 377 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWD 436
Query: 161 LDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYEN- 219
L S C T V + N I+ ++ +++G D ++ W +
Sbjct: 437 LRSKVCIKT----------VFAGSSCNDIVC-------TEQCVMSGHFDKKIRFWDIRSE 479
Query: 220 ---NKLELLHTLEGHEM-PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSS 275
++ELL + ++ P + +S + + + S
Sbjct: 480 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFK----CGS 535
Query: 276 DMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR-GKFIMSVAWSPDGRYIASG 334
D ++VFSPDGS VA G G + ++ ++ G V+KVL + I +VAWSP G ++ S
Sbjct: 536 DWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSV 595
Query: 335 AEGGSVYLF 343
+G L+
Sbjct: 596 DKGCKAVLW 604
Score = 62.9 bits (146), Expect = 2e-09
Identities = 57/286 (19%), Positives = 117/286 (40%), Gaps = 12/286 (4%)
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
F+A ++ +V P + TGG+D VK+W K E +L G + S+
Sbjct: 318 FDAHDGEVNAVQFS--PGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFD 375
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
G + + + S + F D +++ +G H + ++
Sbjct: 376 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+ + K + G + + + + SG + +D+ ++ +E + +
Sbjct: 436 DLRSKVCIKTV-FAGSSCNDIVCTE--QCVMSGHFDKKIRFWDIRSESIVREMELLGK-I 491
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWA--VSVCFSPDGQRMAT 416
+L +P+ L S S D + V ++ + A++ KC + V FSPDG +A
Sbjct: 492 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 551
Query: 417 SAADGSIRVVLLEEFRVLHTF-EEHTHIVCGVQFNADGSKLVSVSK 461
+A+GS+ + + +V ++H+ + V ++ GS +VSV K
Sbjct: 552 GSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 597
Score = 53.2 bits (122), Expect = 2e-06
Identities = 30/122 (24%), Positives = 62/122 (50%), Gaps = 3/122 (2%)
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLD-HKCWAVSVCF 407
L +AH V ++ FSP ++LLA+ D V ++ + E + L S+ F
Sbjct: 315 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 374
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
G + ++ D + R+ ++++R+ HT H+ V +F D +++VS S D+++ +
Sbjct: 375 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 434
Query: 468 YE 469
++
Sbjct: 435 WD 436
Score = 52.4 bits (120), Expect = 3e-06
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 28/319 (8%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
V A H V +V FSP + +G DR V++W++ +C+ FK
Sbjct: 310 VPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCE--FKG------- 360
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ + I S+ D S Y++ D ++W+ ++ +L HTL GH V+S
Sbjct: 361 -SLSGSNAGITSIEFDSAGS--YLLAASNDFASRIWTVDDYRLR--HTLTGHSGKVLSAK 415
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGH-TGKV 298
D I I+ + SS IV + Q GH K+
Sbjct: 416 FLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS-CNDIVCT---EQCVMSGHFDKKI 471
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
+ I + ++ + ++ GK I ++ +P+ + S + + + D+ + T A
Sbjct: 472 RFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG 530
Query: 359 QAVRS----LAFSPKTKLLASASNDGYVNVYNIESAALQNKL--DHKCWAVSVCFSPDGQ 412
S + FSP +A+ S +G + ++++ + ++ L H +V +SP G
Sbjct: 531 FKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGS 590
Query: 413 RMATSAADGSIRVVLLEEF 431
+ + D + VL ++
Sbjct: 591 HVV--SVDKGCKAVLWAQY 607
Score = 47.2 bits (107), Expect = 1e-04
Identities = 24/58 (41%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 10 WT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTL-SVAYSPDGKYIAS 65
WT + FSPDG +V +GS G + I+ V +GK E+VL + ++ +VA+SP G ++ S
Sbjct: 537 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 594
Score = 45.6 bits (103), Expect = 4e-04
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS----VAYSPDGK 61
L + LD +P+ ++S S + + + + +Q G S V +SPDG
Sbjct: 488 LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGS 547
Query: 62 YIASGALDGIINIFDVAQGKLVHTL-EGHAMSIRSLCFSP 100
Y+A+G+ +G + I+ V GK+ L + H+ SI ++ +SP
Sbjct: 548 YVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSP 587
>AC013726-3|AAY14860.1| 523|Homo sapiens unknown protein.
Length = 523
Score = 103 bits (248), Expect = 1e-21
Identities = 83/309 (26%), Positives = 138/309 (44%), Gaps = 29/309 (9%)
Query: 43 VLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVH--TLEGHAMSIRSLCFSP 100
V D +V +SP + +A+G +D + +++V K +L G I S+ F
Sbjct: 233 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 292
Query: 101 DSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
LL S+D +++ V L TL+GH+ VLS F D R VSGS DRT+++WD
Sbjct: 293 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWD 352
Query: 161 LDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYEN- 219
L S C T V + N I+ ++ +++G D ++ W +
Sbjct: 353 LRSKVCIKT----------VFAGSSCNDIVC-------TEQCVMSGHFDKKIRFWDIRSE 395
Query: 220 ---NKLELLHTLEGHEM-PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSS 275
++ELL + ++ P + +S + + + S
Sbjct: 396 SIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFK----CGS 451
Query: 276 DMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR-GKFIMSVAWSPDGRYIASG 334
D ++VFSPDGS VA G G + ++ ++ G V+KVL + I +VAWSP G ++ S
Sbjct: 452 DWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSV 511
Query: 335 AEGGSVYLF 343
+G L+
Sbjct: 512 DKGCKAVLW 520
Score = 62.9 bits (146), Expect = 2e-09
Identities = 57/286 (19%), Positives = 117/286 (40%), Gaps = 12/286 (4%)
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
F+A ++ +V P + TGG+D VK+W K E +L G + S+
Sbjct: 234 FDAHDGEVNAVQFS--PGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFD 291
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
G + + + S + F D +++ +G H + ++
Sbjct: 292 SAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 351
Query: 302 GIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
+ + K + G + + + + SG + +D+ ++ +E + +
Sbjct: 352 DLRSKVCIKTV-FAGSSCNDIVCTE--QCVMSGHFDKKIRFWDIRSESIVREMELLGK-I 407
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWA--VSVCFSPDGQRMAT 416
+L +P+ L S S D + V ++ + A++ KC + V FSPDG +A
Sbjct: 408 TALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAA 467
Query: 417 SAADGSIRVVLLEEFRVLHTF-EEHTHIVCGVQFNADGSKLVSVSK 461
+A+GS+ + + +V ++H+ + V ++ GS +VSV K
Sbjct: 468 GSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 513
Score = 53.2 bits (122), Expect = 2e-06
Identities = 30/122 (24%), Positives = 62/122 (50%), Gaps = 3/122 (2%)
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLD-HKCWAVSVCF 407
L +AH V ++ FSP ++LLA+ D V ++ + E + L S+ F
Sbjct: 231 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 290
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
G + ++ D + R+ ++++R+ HT H+ V +F D +++VS S D+++ +
Sbjct: 291 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 350
Query: 468 YE 469
++
Sbjct: 351 WD 352
Score = 52.4 bits (120), Expect = 3e-06
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 28/319 (8%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
V A H V +V FSP + +G DR V++W++ +C+ FK
Sbjct: 226 VPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCE--FKG------- 276
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ + I S+ D S Y++ D ++W+ ++ +L HTL GH V+S
Sbjct: 277 -SLSGSNAGITSIEFDSAGS--YLLAASNDFASRIWTVDDYRLR--HTLTGHSGKVLSAK 331
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGH-TGKV 298
D I I+ + SS IV + Q GH K+
Sbjct: 332 FLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS-CNDIVCT---EQCVMSGHFDKKI 387
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
+ I + ++ + ++ GK I ++ +P+ + S + + + D+ + T A
Sbjct: 388 RFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPG 446
Query: 359 QAVRS----LAFSPKTKLLASASNDGYVNVYNIESAALQNKL--DHKCWAVSVCFSPDGQ 412
S + FSP +A+ S +G + ++++ + ++ L H +V +SP G
Sbjct: 447 FKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGS 506
Query: 413 RMATSAADGSIRVVLLEEF 431
+ + D + VL ++
Sbjct: 507 HVV--SVDKGCKAVLWAQY 523
Score = 47.2 bits (107), Expect = 1e-04
Identities = 24/58 (41%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 10 WT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTL-SVAYSPDGKYIAS 65
WT + FSPDG +V +GS G + I+ V +GK E+VL + ++ +VA+SP G ++ S
Sbjct: 453 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 510
Score = 45.6 bits (103), Expect = 4e-04
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS----VAYSPDGK 61
L + LD +P+ ++S S + + + + +Q G S V +SPDG
Sbjct: 404 LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGS 463
Query: 62 YIASGALDGIINIFDVAQGKLVHTL-EGHAMSIRSLCFSP 100
Y+A+G+ +G + I+ V GK+ L + H+ SI ++ +SP
Sbjct: 464 YVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSP 503
>X04526-2|CAA28207.1| 340|Homo sapiens protein ( Human liver mRNA
for beta-subunit signal transducing proteins Gs/Gi
(beta-G). ).
Length = 340
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 77.8 bits (183), Expect = 8e-14
Identities = 76/334 (22%), Positives = 134/334 (40%), Gaps = 24/334 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+ H V L + +A+ S D ++ ++N
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 64.5 bits (150), Expect = 8e-10
Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 20/304 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADG 421
S++FS +LL + +D NV++ A L H + + DG +AT + D
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 422 SIRV 425
+++
Sbjct: 335 FLKI 338
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>CR456784-1|CAG33065.1| 340|Homo sapiens GNB1 protein.
Length = 340
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 77.8 bits (183), Expect = 8e-14
Identities = 76/334 (22%), Positives = 134/334 (40%), Gaps = 24/334 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+ H V L + +A+ S D ++ ++N
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 64.5 bits (150), Expect = 8e-10
Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 20/304 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADG 421
S++FS +LL + +D NV++ A L H + + DG +AT + D
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 422 SIRV 425
+++
Sbjct: 335 FLKI 338
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BT007305-1|AAP35969.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 1 protein.
Length = 340
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 77.8 bits (183), Expect = 8e-14
Identities = 76/334 (22%), Positives = 134/334 (40%), Gaps = 24/334 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+ H V L + +A+ S D ++ ++N
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 64.5 bits (150), Expect = 8e-10
Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 20/304 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADG 421
S++FS +LL + +D NV++ A L H + + DG +AT + D
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 422 SIRV 425
+++
Sbjct: 335 FLKI 338
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BC114618-1|AAI14619.1| 332|Homo sapiens GNB1 protein protein.
Length = 332
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 70.5 bits (165), Expect = 1e-11
Identities = 74/323 (22%), Positives = 127/323 (39%), Gaps = 24/323 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLAS 375
+ H V L + +AS
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVAS 329
Score = 66.9 bits (156), Expect = 1e-10
Identities = 42/149 (28%), Positives = 72/149 (48%), Gaps = 3/149 (2%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVS 149
A+ AG L+GH + V + + DG S
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVAS 329
Score = 60.5 bits (140), Expect = 1e-08
Identities = 52/264 (19%), Positives = 104/264 (39%), Gaps = 19/264 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYN 386
S++FS +LL + +D NV++
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWD 298
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BC008991-1|AAH08991.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 1 protein.
Length = 340
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 77.8 bits (183), Expect = 8e-14
Identities = 76/334 (22%), Positives = 134/334 (40%), Gaps = 24/334 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+ H V L + +A+ S D ++ ++N
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 64.5 bits (150), Expect = 8e-10
Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 20/304 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADG 421
S++FS +LL + +D NV++ A L H + + DG +AT + D
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 422 SIRV 425
+++
Sbjct: 335 FLKI 338
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BC005888-1|AAH05888.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 1 protein.
Length = 340
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 77.8 bits (183), Expect = 8e-14
Identities = 76/334 (22%), Positives = 134/334 (40%), Gaps = 24/334 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+ H V L + +A+ S D ++ ++N
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 64.5 bits (150), Expect = 8e-10
Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 20/304 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADG 421
S++FS +LL + +D NV++ A L H + + DG +AT + D
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 422 SIRV 425
+++
Sbjct: 335 FLKI 338
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BC004186-1|AAH04186.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 1 protein.
Length = 340
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 77.8 bits (183), Expect = 8e-14
Identities = 76/334 (22%), Positives = 134/334 (40%), Gaps = 24/334 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+ H V L + +A+ S D ++ ++N
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 64.5 bits (150), Expect = 8e-10
Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 20/304 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADG 421
S++FS +LL + +D NV++ A L H + + DG +AT + D
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 422 SIRV 425
+++
Sbjct: 335 FLKI 338
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>AL109917-5|CAI95654.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 1 protein.
Length = 340
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 77.8 bits (183), Expect = 8e-14
Identities = 76/334 (22%), Positives = 134/334 (40%), Gaps = 24/334 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+ H V L + +A+ S D ++ ++N
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 64.5 bits (150), Expect = 8e-10
Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 20/304 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADG 421
S++FS +LL + +D NV++ A L H + + DG +AT + D
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 422 SIRV 425
+++
Sbjct: 335 FLKI 338
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>AL031282-2|CAI20029.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 1 protein.
Length = 340
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 77.8 bits (183), Expect = 8e-14
Identities = 76/334 (22%), Positives = 134/334 (40%), Gaps = 24/334 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+ H V L + +A+ S D ++ ++N
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 64.5 bits (150), Expect = 8e-10
Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 20/304 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADG 421
S++FS +LL + +D NV++ A L H + + DG +AT + D
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 422 SIRV 425
+++
Sbjct: 335 FLKI 338
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>AF501882-1|AAM15918.1| 340|Homo sapiens guanine nucleotide binding
protein beta 1 protein.
Length = 340
Score = 103 bits (247), Expect = 1e-21
Identities = 53/194 (27%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
T +GH V+S++ +PD + FVSG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F N + S+D
Sbjct: 234 FFPNGNAFATGSDD 247
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 79.4 bits (187), Expect = 3e-14
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ T H V SL+ +P T+L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G AT + D + R+ L + L T+ H +I+CG V F+ G L++
Sbjct: 229 INAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGITSVSFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 77.8 bits (183), Expect = 8e-14
Identities = 76/334 (22%), Positives = 134/334 (40%), Gaps = 24/334 (7%)
Query: 61 KYIASGALDGIINIFDVA---QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
K A L I N D Q + TL GH I ++ + DS+LL++ S DG + ++
Sbjct: 23 KACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW 82
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
D N + +SWV++ A++P G G D +++L + +E N +V
Sbjct: 83 DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT-------REGNVRV 135
Query: 178 WGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVS 237
+ A +S + + IVT D +W E + T GH V+S
Sbjct: 136 --SRELAGHTGYLSCC--RFLDDNQIVTSSGDTTCALWDIETG--QQTTTFTGHTGDVMS 189
Query: 238 VAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK 297
++++PD G + SD+ I F P+G+ ATG
Sbjct: 190 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDAT 249
Query: 298 VTVYGIINGTVDKVLDTRGK-----FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
++ + D+ L T I SV++S GR + +G + + ++D +
Sbjct: 250 CRLFDL---RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG 306
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+ H V L + +A+ S D ++ ++N
Sbjct: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 64.5 bits (150), Expect = 8e-10
Identities = 60/304 (19%), Positives = 119/304 (39%), Gaps = 20/304 (6%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ + D + VS S D + +WD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +Y+ GGLDN+ +++ + + + + L GH +S D
Sbjct: 106 ----------APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D+ + +PD +G ++ +
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
G + I ++ + P+G A+G++ + LFD+ Q M ++ + +
Sbjct: 215 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADG 421
S++FS +LL + +D NV++ A L H + + DG +AT + D
Sbjct: 275 SVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
Query: 422 SIRV 425
+++
Sbjct: 335 FLKI 338
Score = 48.0 bits (109), Expect = 7e-05
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + + D + + GK+ ++ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G Y+A G S+Y +G ++ + H + F +++ S S D
Sbjct: 109 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ H +S+ +PD + + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G+ + S D + +++
Sbjct: 228 DINAICFFPNGNAFATGSDDATCRLFD 254
Score = 34.7 bits (76), Expect = 0.73
Identities = 25/128 (19%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D +++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>AK027854-1|BAB55412.1| 504|Homo sapiens protein ( Homo sapiens
cDNA FLJ14948 fis, clone PLACE2000164, weakly similar to
TIPD PROTEIN. ).
Length = 504
Score = 102 bits (245), Expect = 2e-21
Identities = 83/308 (26%), Positives = 137/308 (44%), Gaps = 27/308 (8%)
Query: 43 VLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVH--TLEGHAMSIRSLCFSP 100
V D + +SP + +A+G +D + +++V K +L G I S+ F
Sbjct: 214 VFDAHDGEVNAAQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 273
Query: 101 DSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
LL S+D +++ V L TL+GH+ VLS F D R VSGS DRT+++WD
Sbjct: 274 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWD 333
Query: 161 LDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENN 220
L S C T V + N I+ ++ +++G D ++ W +
Sbjct: 334 LRSKVCIKT----------VFAGSSCNDIVC-------TEQCVMSGHFDKKIRFWDIRSE 376
Query: 221 KLELLHTLEGHEMPVVSVAVSPD-GETIAXXXXXXXXXXXXXXXGQKIREIQTD---SSD 276
+ L G + ++ ++P+ E ++ K T SD
Sbjct: 377 SIVREMELLG---KITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSATGFKCGSD 433
Query: 277 MWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR-GKFIMSVAWSPDGRYIASGA 335
++VFSPDGS VA G G + ++ ++ G V+KVL + I +VAWSP G ++ S
Sbjct: 434 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVD 493
Query: 336 EGGSVYLF 343
+G L+
Sbjct: 494 KGCKAVLW 501
Score = 62.5 bits (145), Expect = 3e-09
Identities = 54/270 (20%), Positives = 110/270 (40%), Gaps = 10/270 (3%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P + TGG+D VK+W K E +L G + S+ G +
Sbjct: 229 PGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASR 288
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ + S + F D +++ +G H + ++ + + K + G
Sbjct: 289 IWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV-FAGS 347
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
+ + + + SG + +D+ ++ +E + + +L +P+ L S S
Sbjct: 348 SCNDIVCTE--QCVMSGHFDKKIRFWDIRSESIVREMELLGK-ITALDLNPERTELLSCS 404
Query: 378 NDGYVNVYNIESAALQNKLD---HKCWA--VSVCFSPDGQRMATSAADGSIRVVLLEEFR 432
D + V ++ + A++ KC + V FSPDG +A +A+GS+ + + +
Sbjct: 405 RDDLLKVIDLRTNAIKQTFSATGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGK 464
Query: 433 VLHTF-EEHTHIVCGVQFNADGSKLVSVSK 461
V ++H+ + V ++ GS +VSV K
Sbjct: 465 VEKVLSKQHSSSINAVAWSPSGSHVVSVDK 494
Score = 52.4 bits (120), Expect = 3e-06
Identities = 30/122 (24%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI--ESAALQNKLD-HKCWAVSVCF 407
L +AH V + FSP ++LLA+ D V ++ + E + L S+ F
Sbjct: 212 LCVFDAHDGEVNAAQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEF 271
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
G + ++ D + R+ ++++R+ HT H+ V +F D +++VS S D+++ +
Sbjct: 272 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 331
Query: 468 YE 469
++
Sbjct: 332 WD 333
Score = 50.8 bits (116), Expect = 1e-05
Identities = 66/319 (20%), Positives = 127/319 (39%), Gaps = 28/319 (8%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
V A H V + FSP + +G DR V++W++ +C+ FK
Sbjct: 207 VPATALCVFDAHDGEVNAAQFSPGSRLLATGGMDRRVKLWEVFGEKCE--FKG------- 257
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ + I S+ D S Y++ D ++W+ ++ +L HTL GH V+S
Sbjct: 258 -SLSGSNAGITSIEFDSAGS--YLLAASNDFASRIWTVDDYRLR--HTLTGHSGKVLSAK 312
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGH-TGKV 298
D I I+ + SS IV + Q GH K+
Sbjct: 313 FLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS-CNDIVCT---EQCVMSGHFDKKI 368
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
+ I + ++ + ++ GK I ++ +P+ + S + + + D+ + T A
Sbjct: 369 RFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSATG 427
Query: 359 QAVRS----LAFSPKTKLLASASNDGYVNVYNIESAALQNKL--DHKCWAVSVCFSPDGQ 412
S + FSP +A+ S +G + ++++ + ++ L H +V +SP G
Sbjct: 428 FKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGS 487
Query: 413 RMATSAADGSIRVVLLEEF 431
+ + D + VL ++
Sbjct: 488 HVV--SVDKGCKAVLWAQY 504
Score = 47.2 bits (107), Expect = 1e-04
Identities = 24/58 (41%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 10 WT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTL-SVAYSPDGKYIAS 65
WT + FSPDG +V +GS G + I+ V +GK E+VL + ++ +VA+SP G ++ S
Sbjct: 434 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 491
Score = 46.0 bits (104), Expect = 3e-04
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 5/100 (5%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS----VAYSPDGK 61
L + LD +P+ ++S S + + + + +Q G S V +SPDG
Sbjct: 385 LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSATGFKCGSDWTRVVFSPDGS 444
Query: 62 YIASGALDGIINIFDVAQGKLVHTL-EGHAMSIRSLCFSP 100
Y+A+G+ +G + I+ V GK+ L + H+ SI ++ +SP
Sbjct: 445 YVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSP 484
>M24194-1|AAA59626.1| 317|Homo sapiens MHC B complex protein 12.3
protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>CR541909-1|CAG46707.1| 317|Homo sapiens GNB2L1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>CR456978-1|CAG33259.1| 317|Homo sapiens GNB2L1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>CR456762-1|CAG33043.1| 655|Homo sapiens KATNB1 protein.
Length = 655
Score = 102 bits (244), Expect = 3e-21
Identities = 54/175 (30%), Positives = 91/175 (52%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+++GS +G I ++ +E+ K + L S+ + P G+++ASG+ D I ++D+ +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
V GH+ ++R L FSPD + L + +DD +KL+D+ + GH V V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
P+ SGS+DRT+R WDL+ Q + V V FN + + S +D
Sbjct: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Score = 90.2 bits (214), Expect = 1e-17
Identities = 58/264 (21%), Positives = 119/264 (45%), Gaps = 17/264 (6%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF 98
K ++++ + V G+ +A+G D +N++ + + + +L GH + S+
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 99 SPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRV 158
+ +L++ GS G ++++D+ A + TL GH + + S+ F P G+ SGS D +++
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 159 WDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE 218
WD+ C ++ H+ V ++F+ + + S ++ D+ VK+W
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAAD--------------DHTVKLWDLT 177
Query: 219 NNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
K ++ GH PV V P+ +A Q + I+ + +
Sbjct: 178 AGK--MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVR 235
Query: 279 KIVFSPDGSQVATGGHTGKVTVYG 302
++F+PDG + +G + VYG
Sbjct: 236 SVLFNPDGCCLYSGCQ-DSLRVYG 258
Score = 85.8 bits (203), Expect = 3e-16
Identities = 53/181 (29%), Positives = 96/181 (53%), Gaps = 2/181 (1%)
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+ G +G + V+ + + + L I S+ + P G ++ASG++ ++ L+D+ +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-F 407
+ H+QAVR L FSP K LASA++D V ++++ + + ++ V+V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
P+ +A+ ++D +IR LE+F+V+ E V V FN DG L S +D S+ +
Sbjct: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRV 256
Query: 468 Y 468
Y
Sbjct: 257 Y 257
Score = 83.0 bits (196), Expect = 2e-15
Identities = 49/161 (30%), Positives = 85/161 (52%), Gaps = 5/161 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIAS 65
++ +LDF P G+ V SGS I ++ + ++ V RG + + +SPDGK++AS
Sbjct: 107 NICSLDFHPYGEFVASGSQDTNIKLWDIR--RKGCVFRYRGHSQAVRCLRFSPDGKWLAS 164
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
A D + ++D+ GK++ GH + + F P+ LL +GS D ++ +D+ +
Sbjct: 165 AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVV 224
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQC 166
+ G V SV F+PDG SG D ++RV+ + +C
Sbjct: 225 SCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
Score = 80.2 bits (189), Expect = 1e-14
Identities = 58/249 (23%), Positives = 105/249 (42%), Gaps = 17/249 (6%)
Query: 89 HAMSIRSLCFSPDS-QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRF 147
HA ++ SL S +LL TG DD + L+ + N +L+GH S V SV + +
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 148 VSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGG 207
V+GS ++RVWDL++ + T H + + F+ P +++ +G
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFH--------------PYGEFVASGS 124
Query: 208 LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI 267
D +K+W + GH V + SPDG+ +A G+ +
Sbjct: 125 QDTNIKLWDIRRKGCVFRY--RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMM 182
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
E + + + F P+ +A+G + + + V ++ + SV ++PD
Sbjct: 183 SEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPD 242
Query: 328 GRYIASGAE 336
G + SG +
Sbjct: 243 GCCLYSGCQ 251
Score = 79.4 bits (187), Expect = 3e-14
Identities = 55/206 (26%), Positives = 103/206 (50%), Gaps = 2/206 (0%)
Query: 266 KIREIQTDSSDMWKIVFSP-DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAW 324
K++EI +S++ +V G +ATGG +V ++ I L + SV
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 325 SPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNV 384
+ I +G++ GS+ ++D+ K+L T+ H + SL F P + +AS S D + +
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 385 YNIESAALQNKLDHKCWAV-SVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
++I + AV + FSPDG+ +A++A D ++++ L +++ F HT
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V V+F+ + L S S D++I ++
Sbjct: 192 VNVVEFHPNEYLLASGSSDRTIRFWD 217
>BT007022-1|AAP35668.1| 655|Homo sapiens katanin p80
(WD40-containing) subunit B 1 protein.
Length = 655
Score = 102 bits (244), Expect = 3e-21
Identities = 54/175 (30%), Positives = 91/175 (52%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+++GS +G I ++ +E+ K + L S+ + P G+++ASG+ D I ++D+ +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
V GH+ ++R L FSPD + L + +DD +KL+D+ + GH V V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
P+ SGS+DRT+R WDL+ Q + V V FN + + S +D
Sbjct: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Score = 90.2 bits (214), Expect = 1e-17
Identities = 58/264 (21%), Positives = 119/264 (45%), Gaps = 17/264 (6%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF 98
K ++++ + V G+ +A+G D +N++ + + + +L GH + S+
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 99 SPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRV 158
+ +L++ GS G ++++D+ A + TL GH + + S+ F P G+ SGS D +++
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 159 WDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE 218
WD+ C ++ H+ V ++F+ + + S ++ D+ VK+W
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAAD--------------DHTVKLWDLT 177
Query: 219 NNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
K ++ GH PV V P+ +A Q + I+ + +
Sbjct: 178 AGK--MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVR 235
Query: 279 KIVFSPDGSQVATGGHTGKVTVYG 302
++F+PDG + +G + VYG
Sbjct: 236 SVLFNPDGCCLYSGCQ-DSLRVYG 258
Score = 85.8 bits (203), Expect = 3e-16
Identities = 53/181 (29%), Positives = 96/181 (53%), Gaps = 2/181 (1%)
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+ G +G + V+ + + + L I S+ + P G ++ASG++ ++ L+D+ +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-F 407
+ H+QAVR L FSP K LASA++D V ++++ + + ++ V+V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
P+ +A+ ++D +IR LE+F+V+ E V V FN DG L S +D S+ +
Sbjct: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRV 256
Query: 468 Y 468
Y
Sbjct: 257 Y 257
Score = 83.0 bits (196), Expect = 2e-15
Identities = 49/161 (30%), Positives = 85/161 (52%), Gaps = 5/161 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIAS 65
++ +LDF P G+ V SGS I ++ + ++ V RG + + +SPDGK++AS
Sbjct: 107 NICSLDFHPYGEFVASGSQDTNIKLWDIR--RKGCVFRYRGHSQAVRCLRFSPDGKWLAS 164
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
A D + ++D+ GK++ GH + + F P+ LL +GS D ++ +D+ +
Sbjct: 165 AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVV 224
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQC 166
+ G V SV F+PDG SG D ++RV+ + +C
Sbjct: 225 SCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
Score = 80.2 bits (189), Expect = 1e-14
Identities = 58/249 (23%), Positives = 105/249 (42%), Gaps = 17/249 (6%)
Query: 89 HAMSIRSLCFSPDS-QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRF 147
HA ++ SL S +LL TG DD + L+ + N +L+GH S V SV + +
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 148 VSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGG 207
V+GS ++RVWDL++ + T H + + F+ P +++ +G
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFH--------------PYGEFVASGS 124
Query: 208 LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI 267
D +K+W + GH V + SPDG+ +A G+ +
Sbjct: 125 QDTNIKLWDIRRKGCVFRY--RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMM 182
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
E + + + F P+ +A+G + + + V ++ + SV ++PD
Sbjct: 183 SEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPD 242
Query: 328 GRYIASGAE 336
G + SG +
Sbjct: 243 GCCLYSGCQ 251
Score = 79.4 bits (187), Expect = 3e-14
Identities = 55/206 (26%), Positives = 103/206 (50%), Gaps = 2/206 (0%)
Query: 266 KIREIQTDSSDMWKIVFSP-DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAW 324
K++EI +S++ +V G +ATGG +V ++ I L + SV
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 325 SPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNV 384
+ I +G++ GS+ ++D+ K+L T+ H + SL F P + +AS S D + +
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 385 YNIESAALQNKLDHKCWAV-SVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
++I + AV + FSPDG+ +A++A D ++++ L +++ F HT
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V V+F+ + L S S D++I ++
Sbjct: 192 VNVVEFHPNEYLLASGSSDRTIRFWD 217
>BC032006-1|AAH32006.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>BC021993-1|AAH21993.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>BC019362-1|AAH19362.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>BC019093-1|AAH19093.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>BC017287-1|AAH17287.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>BC014788-1|AAH14788.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>BC014256-1|AAH14256.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>BC010119-1|AAH10119.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>BC001353-1|AAH01353.1| 655|Homo sapiens katanin p80 (WD repeat
containing) subunit B 1 protein.
Length = 655
Score = 102 bits (244), Expect = 3e-21
Identities = 54/175 (30%), Positives = 91/175 (52%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+++GS +G I ++ +E+ K + L S+ + P G+++ASG+ D I ++D+ +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
V GH+ ++R L FSPD + L + +DD +KL+D+ + GH V V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
P+ SGS+DRT+R WDL+ Q + V V FN + + S +D
Sbjct: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Score = 90.2 bits (214), Expect = 1e-17
Identities = 58/264 (21%), Positives = 119/264 (45%), Gaps = 17/264 (6%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF 98
K ++++ + V G+ +A+G D +N++ + + + +L GH + S+
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 99 SPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRV 158
+ +L++ GS G ++++D+ A + TL GH + + S+ F P G+ SGS D +++
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 159 WDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE 218
WD+ C ++ H+ V ++F+ + + S ++ D+ VK+W
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAAD--------------DHTVKLWDLT 177
Query: 219 NNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
K ++ GH PV V P+ +A Q + I+ + +
Sbjct: 178 AGK--MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVR 235
Query: 279 KIVFSPDGSQVATGGHTGKVTVYG 302
++F+PDG + +G + VYG
Sbjct: 236 SVLFNPDGCCLYSGCQ-DSLRVYG 258
Score = 85.8 bits (203), Expect = 3e-16
Identities = 53/181 (29%), Positives = 96/181 (53%), Gaps = 2/181 (1%)
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+ G +G + V+ + + + L I S+ + P G ++ASG++ ++ L+D+ +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-F 407
+ H+QAVR L FSP K LASA++D V ++++ + + ++ V+V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
P+ +A+ ++D +IR LE+F+V+ E V V FN DG L S +D S+ +
Sbjct: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRV 256
Query: 468 Y 468
Y
Sbjct: 257 Y 257
Score = 83.0 bits (196), Expect = 2e-15
Identities = 49/161 (30%), Positives = 85/161 (52%), Gaps = 5/161 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIAS 65
++ +LDF P G+ V SGS I ++ + ++ V RG + + +SPDGK++AS
Sbjct: 107 NICSLDFHPYGEFVASGSQDTNIKLWDIR--RKGCVFRYRGHSQAVRCLRFSPDGKWLAS 164
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
A D + ++D+ GK++ GH + + F P+ LL +GS D ++ +D+ +
Sbjct: 165 AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVV 224
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQC 166
+ G V SV F+PDG SG D ++RV+ + +C
Sbjct: 225 SCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
Score = 80.2 bits (189), Expect = 1e-14
Identities = 58/249 (23%), Positives = 105/249 (42%), Gaps = 17/249 (6%)
Query: 89 HAMSIRSLCFSPDS-QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRF 147
HA ++ SL S +LL TG DD + L+ + N +L+GH S V SV + +
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 148 VSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGG 207
V+GS ++RVWDL++ + T H + + F+ P +++ +G
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFH--------------PYGEFVASGS 124
Query: 208 LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI 267
D +K+W + GH V + SPDG+ +A G+ +
Sbjct: 125 QDTNIKLWDIRRKGCVFRY--RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMM 182
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
E + + + F P+ +A+G + + + V ++ + SV ++PD
Sbjct: 183 SEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPD 242
Query: 328 GRYIASGAE 336
G + SG +
Sbjct: 243 GCCLYSGCQ 251
Score = 79.4 bits (187), Expect = 3e-14
Identities = 55/206 (26%), Positives = 103/206 (50%), Gaps = 2/206 (0%)
Query: 266 KIREIQTDSSDMWKIVFSP-DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAW 324
K++EI +S++ +V G +ATGG +V ++ I L + SV
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 325 SPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNV 384
+ I +G++ GS+ ++D+ K+L T+ H + SL F P + +AS S D + +
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 385 YNIESAALQNKLDHKCWAV-SVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
++I + AV + FSPDG+ +A++A D ++++ L +++ F HT
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V V+F+ + L S S D++I ++
Sbjct: 192 VNVVEFHPNEYLLASGSSDRTIRFWD 217
>BC000873-1|AAH00873.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 4 protein.
Length = 340
Score = 102 bits (244), Expect = 3e-21
Identities = 55/194 (28%), Positives = 101/194 (52%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F DSQ ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
A T +GH+ V+S++ SPD + FVSG+ D + ++WD+ C+ +F H + V
Sbjct: 174 AQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVS 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFATGSDD 247
Score = 80.2 bits (189), Expect = 1e-14
Identities = 70/305 (22%), Positives = 126/305 (41%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L + +E N +V + +S S+ IV
Sbjct: 110 NYVACGGLDNICSIYNLKT-------REGNVRV--SRELPGHTGYLSCCRFLDDSQ--IV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + T GH V+S+++SPD T G
Sbjct: 159 TSSGDTTCALWDIET--AQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM---S 321
+ SD+ + F P+G ATG ++ + + +L + I S
Sbjct: 217 MCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDL-RADQELLLYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LRIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L SPD + +SG+ ++ + G Q +V++ P+G A+G+
Sbjct: 186 DVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +R+W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 72.1 bits (169), Expect = 4e-12
Identities = 65/243 (26%), Positives = 106/243 (43%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ + T GH+ + SL SPD + ++G+ D KL+D+
Sbjct: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
+ +GH S + +V+F P+G F +GS D T R++DL + Q + H++ + G
Sbjct: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQ-ELLLYSHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SV+ K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVAFSK--SGRLLLAGYDDFNCNVW--DTLKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 63.3 bits (147), Expect = 2e-09
Identities = 55/251 (21%), Positives = 103/251 (41%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ + T H+ V SL+ SP + S + D +++I + Q+ H
Sbjct: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
+V F P+G AT + D + R+ L + L + H +I+CG V F+ G L++
Sbjct: 229 INAVSFFPNGYAFATGSDDATCRLFDLRADQELLLY-SHDNIICGITSVAFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D S++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRF-LDDSQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BC000366-1|AAH00366.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>BC000214-1|AAH00214.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 81.4 bits (192), Expect = 6e-15
Identities = 73/317 (23%), Positives = 132/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D+++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 219 WDLNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>AY159316-1|AAO21313.1| 347|Homo sapiens lung cancer oncogene 7
protein.
Length = 347
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 89 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 148
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 149 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 197
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 198 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 255
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 256 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 313
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 314 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 345
Score = 82.6 bits (195), Expect = 3e-15
Identities = 77/343 (22%), Positives = 139/343 (40%), Gaps = 29/343 (8%)
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTV 156
FS S +L + + L GTL GH WV +A +P +S S D+T+
Sbjct: 11 FSKPSSAILVAAATHALAAAMTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTI 70
Query: 157 RVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWS 216
+W L + + + ++ ++ + +S D + ++G D +++W
Sbjct: 71 IMWKLTRDETNYGIPQR-----ALRGHSHFVSDVVISSD----GQFALSGSWDGTLRLWD 121
Query: 217 YENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSD 276
GH V+SVA S D I K +Q +S
Sbjct: 122 LTTG--TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHS 178
Query: 277 MWK--IVFSPDGSQ--VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
W + FSP+ S + + G V V+ + N + ++ +V SPDG A
Sbjct: 179 EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCA 238
Query: 333 SGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL 392
SG + G L+D+++GK L+T++ + +L FSP L +A+ + ++++E +
Sbjct: 239 SGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAATGPS-IKIWDLEGKII 296
Query: 393 QNKLDHKC----------WAVSVCFSPDGQRMATSAADGSIRV 425
++L + S+ +S DGQ + D +RV
Sbjct: 297 VDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRV 339
Score = 72.5 bits (170), Expect = 3e-12
Identities = 58/229 (25%), Positives = 104/229 (45%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 34 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 93
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 94 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 153
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 154 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 212
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + L E + L+T +
Sbjct: 213 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 261
Score = 72.5 bits (170), Expect = 3e-12
Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 83 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 142
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 143 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 202
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 203 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 248
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W K L+TL+G ++ + ++ SP+
Sbjct: 249 WDLNEGK--HLYTLDGGDI-INALCFSPN 274
Score = 71.7 bits (168), Expect = 5e-12
Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 102 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 161
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 162 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 220
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WDL+ + +T + D + + F+ +
Sbjct: 221 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-DGGDIINALCFSPNRYWLC 279
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 280 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 328
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 83 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 142
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 143 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 202
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 203 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 250
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 227 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 285
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 286 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 342
>AK222488-1|BAD96208.1| 317|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2-like 1 varia
protein.
Length = 317
Score = 102 bits (244), Expect = 3e-21
Identities = 81/272 (29%), Positives = 127/272 (46%), Gaps = 24/272 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH+ + + S D Q L+GS DG ++L+D+ GH VLSVAFS D +
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVT 205
+ VSGS D+T+++W+ + C++T ++ + W + V S IV+
Sbjct: 119 QIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------VSCVRFSPNSSNPIIVS 167
Query: 206 GGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQ 265
G D LVKVW+ N KL+ H GH + +V VSPDG A G+
Sbjct: 168 CGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDFNEGK 225
Query: 266 KIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--IINGTVDKVLDTRGKF-- 318
+ + D D+ + FSP+ + ATG + G I++ +V+ T K
Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Query: 319 --IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
S+AWS DG+ + +G V ++ V+ G
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 80.6 bits (190), Expect = 1e-14
Identities = 73/317 (23%), Positives = 131/317 (41%), Gaps = 29/317 (9%)
Query: 124 LAGTLSGHASWVLSVAFSPD-GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
L GTL GH WV +A +P +S S D+T+ +W L + + + ++
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-----ALRG 61
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
++ + +S D + ++G D +++W GH V+SVA S
Sbjct: 62 HSHFVSDVVISSD----GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSS 115
Query: 243 DGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGSQ--VATGGHTGKV 298
D I K +Q +S W + FSP+ S + + G V
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKY-TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 299 TVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHA 358
V+ + N + ++ +V SPDG ASG + G L+D ++GK L+T++
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDFNEGKHLYTLDG-G 233
Query: 359 QAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----------WAVSVCFS 408
+ +L FSP L +A+ + ++++E + ++L + S+ +S
Sbjct: 234 DIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
Query: 409 PDGQRMATSAADGSIRV 425
DGQ + D +RV
Sbjct: 293 ADGQTLFAGYTDNLVRV 309
Score = 74.1 bits (174), Expect = 1e-12
Identities = 53/209 (25%), Positives = 95/209 (45%), Gaps = 20/209 (9%)
Query: 38 GKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC 97
G ++ L F V S DG++ SG+ DG + ++D+ G GH + S+
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKR--FVSGSADR 154
FS D++ +++GS D +KL++ + H+ WV V FSP+ VS D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKV 214
V+VW+L + + + H + ++VS P +GG D +
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYL----------NTVTVS----PDGSLCASGGKDGQAML 218
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPD 243
W + K L+TL+G ++ + ++ SP+
Sbjct: 219 WDFNEGK--HLYTLDGGDI-INALCFSPN 244
Score = 70.9 bits (166), Expect = 9e-12
Identities = 57/229 (24%), Positives = 103/229 (44%), Gaps = 12/229 (5%)
Query: 221 KLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX------XXXXXXXGQKIREIQTDS 274
++ L TL+GH V +A +P + G R ++ S
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
+ +V S DG +G G + ++ + GT + K ++SVA+S D R I SG
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 335 AEGGSVYLFDVSQGKMLHTI--EAHAQAVRSLAFSPKTK--LLASASNDGYVNVYNIESA 390
+ ++ L++ + G +T+ E+H++ V + FSP + ++ S D V V+N+ +
Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
Query: 391 ALQ-NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ N + H + +V SPDG A+ DG + E + L+T +
Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDFNEGKHLYTLD 231
Score = 70.1 bits (164), Expect = 2e-11
Identities = 63/238 (26%), Positives = 115/238 (48%), Gaps = 16/238 (6%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
S DG+ +SGS G + ++ + +G + K LSVA+S D + I SG+ D I +
Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Query: 75 FDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSG 130
++ G +T+ E H+ + + FSP+S ++++ D +K++++ + L G
Sbjct: 132 WNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
Query: 131 HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKII 190
H ++ +V SPDG SG D +WD + + +T + D + + F+ +
Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDFNEGKHLYTL-DGGDIINALCFSPNRYWLC 249
Query: 191 SVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMP-VVSVAVSPDGETI 247
+ + GPS I L+ + V + K E++ T E P S+A S DG+T+
Sbjct: 250 AAT---GPS---IKIWDLEGKIIV---DELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Score = 58.8 bits (136), Expect = 4e-08
Identities = 42/168 (25%), Positives = 71/168 (42%), Gaps = 4/168 (2%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
G + L F+ V S DG++ SG+ G++ L+D++ G H + V S+A
Sbjct: 53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVA 112
Query: 366 FSPKTKLLASASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQR--MATSAADG 421
FS + + S S D + ++N D H W V FSP+ + + D
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++V L ++ HT + V + DGS S KD +++
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 38.3 bits (85), Expect = 0.059
Identities = 28/117 (23%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ GK LD G ++ +SP+ ++ +
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDFNEGKHLYTLD-GGDIINALCFSPNRYWLCAATGPS 255
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
>AF300648-1|AAG18442.1| 340|Homo sapiens guanine nucleotide binding
protein beta subunit 4 protein.
Length = 340
Score = 102 bits (244), Expect = 3e-21
Identities = 55/194 (28%), Positives = 101/194 (52%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G Y+A
Sbjct: 55 LAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+++ +G ++ L GH + F DSQ ++T S D L+D+
Sbjct: 115 GGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
A T +GH+ V+S++ SPD + FVSG+ D + ++WD+ C+ +F H + V
Sbjct: 174 AQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVS 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFATGSDD 247
Score = 80.2 bits (189), Expect = 1e-14
Identities = 70/305 (22%), Positives = 126/305 (41%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L + +E N +V + +S S+ IV
Sbjct: 110 NYVACGGLDNICSIYNLKT-------REGNVRV--SRELPGHTGYLSCCRFLDDSQ--IV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + T GH V+S+++SPD T G
Sbjct: 159 TSSGDTTCALWDIET--AQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM---S 321
+ SD+ + F P+G ATG ++ + + +L + I S
Sbjct: 217 MCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDL-RADQELLLYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LRIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L SPD + +SG+ ++ + G Q +V++ P+G A+G+
Sbjct: 186 DVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +R+W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 72.1 bits (169), Expect = 4e-12
Identities = 65/243 (26%), Positives = 106/243 (43%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ + T GH+ + SL SPD + ++G+ D KL+D+
Sbjct: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
+ +GH S + +V+F P+G F +GS D T R++DL + Q + H++ + G
Sbjct: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQ-ELLLYSHDNIICG------ 272
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SV+ K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 273 ---ITSVAFSK--SGRLLLAGYDDFNCNVW--DTLKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 63.3 bits (147), Expect = 2e-09
Identities = 55/251 (21%), Positives = 103/251 (41%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ D + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + + S + + L
Sbjct: 110 NYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ + T H+ V SL+ SP + S + D +++I + Q+ H
Sbjct: 169 WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
+V F P+G AT + D + R+ L + L + H +I+CG V F+ G L++
Sbjct: 229 INAVSFFPNGYAFATGSDDATCRLFDLRADQELLLY-SHDNIICGITSVAFSKSGRLLLA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ + ++LL SAS DG + +++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ RV HT + +F D S++V+ S
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRF-LDDSQIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>M36429-1|AAA63264.1| 340|Homo sapiens protein ( Human transducin
beta-2 subunit mRNA, complete cds. ).
Length = 340
Score = 101 bits (243), Expect = 4e-21
Identities = 52/194 (26%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+ + +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
+GH+ V+S++ +PDG+ FVSG+ D ++++WD+ C+ TF H + V
Sbjct: 174 GQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVA 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFTTGSDD 247
Score = 78.2 bits (184), Expect = 6e-14
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L +PDG+ +SG+ I ++ V Q +VA+ P+G +G+
Sbjct: 186 DVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +++W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 64/305 (20%), Positives = 125/305 (40%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D ++ L + +E N +V + + + S + + I+
Sbjct: 110 NFVACGGLDNICSIYSLKT-------REGNVRV-SRELPGHTGYL---SCCRFLDDNQII 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + GH V+S++++PDG T
Sbjct: 159 TSSGDTTCALWDIETGQQTV--GFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ + F P+G TG ++ + + ++ + I S
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 70.1 bits (164), Expect = 2e-11
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ GH+ + SL +PD + ++G+ D +KL+DV +
Sbjct: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T GH S + +VAF P+G F +GS D T R++DL + Q + H++ + G+ A
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIICGITSVAF 278
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
S S ++ G D +W + K + L GH+ V + V+ DG
Sbjct: 279 SR-----------SGRLLLAGYDDFNCNIW--DAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 68.9 bits (161), Expect = 4e-11
Identities = 63/291 (21%), Positives = 121/291 (41%), Gaps = 16/291 (5%)
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N+I + G S +T GLD + ++ ++ TL GH + ++ D
Sbjct: 16 NQIRDARKACGDSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 247 IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-- 304
+ K+ I SS + ++P G+ VA GG ++Y +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129
Query: 305 --NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
N V + L ++ + D + I S + + L+D+ G+ H+ V
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD-TTCALWDIETGQQTVGFAGHSGDVM 188
Query: 363 SLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
SL+ +P + S + D + ++++ +S Q + H+ +V F P+G T + D
Sbjct: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVSVSKDKSINIYE 469
+ R+ L + L + H +I+CG V F+ G L++ D + NI++
Sbjct: 249 TCRLFDLRADQELLMY-SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
>M16514-1|AAA03179.1| 340|Homo sapiens GNB2 protein.
Length = 340
Score = 101 bits (243), Expect = 4e-21
Identities = 52/194 (26%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+ + +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
+GH+ V+S++ +PDG+ FVSG+ D ++++WD+ C+ TF H + V
Sbjct: 174 GQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVA 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFTTGSDD 247
Score = 78.2 bits (184), Expect = 6e-14
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L +PDG+ +SG+ I ++ V Q +VA+ P+G +G+
Sbjct: 186 DVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +++W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 64/305 (20%), Positives = 125/305 (40%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D ++ L + +E N +V + + + S + + I+
Sbjct: 110 NFVACGGLDNICSIYSLKT-------REGNVRV-SRELPGHTGYL---SCCRFLDDNQII 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + GH V+S++++PDG T
Sbjct: 159 TSSGDTTCALWDIETGQQTV--GFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ + F P+G TG ++ + + ++ + I S
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 70.1 bits (164), Expect = 2e-11
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ GH+ + SL +PD + ++G+ D +KL+DV +
Sbjct: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T GH S + +VAF P+G F +GS D T R++DL + Q + H++ + G+ A
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIICGITSVAF 278
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
S S ++ G D +W + K + L GH+ V + V+ DG
Sbjct: 279 SR-----------SGRLLLAGYDDFNCNIW--DAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 68.9 bits (161), Expect = 4e-11
Identities = 63/291 (21%), Positives = 121/291 (41%), Gaps = 16/291 (5%)
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N+I + G S +T GLD + ++ ++ TL GH + ++ D
Sbjct: 16 NQIRDARKACGDSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 247 IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-- 304
+ K+ I SS + ++P G+ VA GG ++Y +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129
Query: 305 --NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
N V + L ++ + D + I S + + L+D+ G+ H+ V
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD-TTCALWDIETGQQTVGFAGHSGDVM 188
Query: 363 SLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
SL+ +P + S + D + ++++ +S Q + H+ +V F P+G T + D
Sbjct: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVSVSKDKSINIYE 469
+ R+ L + L + H +I+CG V F+ G L++ D + NI++
Sbjct: 249 TCRLFDLRADQELLMY-SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
>CR541729-1|CAG46530.1| 340|Homo sapiens GNB2 protein.
Length = 340
Score = 101 bits (243), Expect = 4e-21
Identities = 52/194 (26%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+ + +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
+GH+ V+S++ +PDG+ FVSG+ D ++++WD+ C+ TF H + V
Sbjct: 174 GQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVA 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFTTGSDD 247
Score = 78.2 bits (184), Expect = 6e-14
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L +PDG+ +SG+ I ++ V Q +VA+ P+G +G+
Sbjct: 186 DVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +++W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 64/305 (20%), Positives = 125/305 (40%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D ++ L + +E N +V + + + S + + I+
Sbjct: 110 NFVACGGLDNICSIYSLKT-------REGNVRV-SRELPGHTGYL---SCCRFLDDNQII 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + GH V+S++++PDG T
Sbjct: 159 TSSGDTTCALWDIETGQQTV--GFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ + F P+G TG ++ + + ++ + I S
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 70.1 bits (164), Expect = 2e-11
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ GH+ + SL +PD + ++G+ D +KL+DV +
Sbjct: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T GH S + +VAF P+G F +GS D T R++DL + Q + H++ + G+ A
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIICGITSVAF 278
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
S S ++ G D +W + K + L GH+ V + V+ DG
Sbjct: 279 SR-----------SGRLLLAGYDDFNCNIW--DAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 68.9 bits (161), Expect = 4e-11
Identities = 63/291 (21%), Positives = 121/291 (41%), Gaps = 16/291 (5%)
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N+I + G S +T GLD + ++ ++ TL GH + ++ D
Sbjct: 16 NQIRDARKACGDSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 247 IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-- 304
+ K+ I SS + ++P G+ VA GG ++Y +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129
Query: 305 --NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
N V + L ++ + D + I S + + L+D+ G+ H+ V
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD-TTCALWDIETGQQTVGFAGHSGDVM 188
Query: 363 SLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
SL+ +P + S + D + ++++ +S Q + H+ +V F P+G T + D
Sbjct: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVSVSKDKSINIYE 469
+ R+ L + L + H +I+CG V F+ G L++ D + NI++
Sbjct: 249 TCRLFDLRADQELLMY-SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
>BC068003-1|AAH68003.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2 protein.
Length = 340
Score = 101 bits (243), Expect = 4e-21
Identities = 52/194 (26%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+ + +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
+GH+ V+S++ +PDG+ FVSG+ D ++++WD+ C+ TF H + V
Sbjct: 174 GQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVA 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFTTGSDD 247
Score = 78.2 bits (184), Expect = 6e-14
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L +PDG+ +SG+ I ++ V Q +VA+ P+G +G+
Sbjct: 186 DVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +++W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 64/305 (20%), Positives = 125/305 (40%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D ++ L + +E N +V + + + S + + I+
Sbjct: 110 NFVACGGLDNICSIYSLKT-------REGNVRV-SRELPGHTGYL---SCCRFLDDNQII 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + GH V+S++++PDG T
Sbjct: 159 TSSGDTTCALWDIETGQQTV--GFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ + F P+G TG ++ + + ++ + I S
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 70.1 bits (164), Expect = 2e-11
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ GH+ + SL +PD + ++G+ D +KL+DV +
Sbjct: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T GH S + +VAF P+G F +GS D T R++DL + Q + H++ + G+ A
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIICGITSVAF 278
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
S S ++ G D +W + K + L GH+ V + V+ DG
Sbjct: 279 SR-----------SGRLLLAGYDDFNCNIW--DAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 68.9 bits (161), Expect = 4e-11
Identities = 63/291 (21%), Positives = 121/291 (41%), Gaps = 16/291 (5%)
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N+I + G S +T GLD + ++ ++ TL GH + ++ D
Sbjct: 16 NQIRDARKACGDSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 247 IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-- 304
+ K+ I SS + ++P G+ VA GG ++Y +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129
Query: 305 --NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
N V + L ++ + D + I S + + L+D+ G+ H+ V
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD-TTCALWDIETGQQTVGFAGHSGDVM 188
Query: 363 SLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
SL+ +P + S + D + ++++ +S Q + H+ +V F P+G T + D
Sbjct: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVSVSKDKSINIYE 469
+ R+ L + L + H +I+CG V F+ G L++ D + NI++
Sbjct: 249 TCRLFDLRADQELLMY-SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
>BC012348-1|AAH12348.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2 protein.
Length = 340
Score = 101 bits (243), Expect = 4e-21
Identities = 52/194 (26%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+ + +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
+GH+ V+S++ +PDG+ FVSG+ D ++++WD+ C+ TF H + V
Sbjct: 174 GQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVA 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFTTGSDD 247
Score = 78.2 bits (184), Expect = 6e-14
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L +PDG+ +SG+ I ++ V Q +VA+ P+G +G+
Sbjct: 186 DVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +++W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 64/305 (20%), Positives = 125/305 (40%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D ++ L + +E N +V + + + S + + I+
Sbjct: 110 NFVACGGLDNICSIYSLKT-------REGNVRV-SRELPGHTGYL---SCCRFLDDNQII 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + GH V+S++++PDG T
Sbjct: 159 TSSGDTTCALWDIETGQQTV--GFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ + F P+G TG ++ + + ++ + I S
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 70.1 bits (164), Expect = 2e-11
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ GH+ + SL +PD + ++G+ D +KL+DV +
Sbjct: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T GH S + +VAF P+G F +GS D T R++DL + Q + H++ + G+ A
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIICGITSVAF 278
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
S S ++ G D +W + K + L GH+ V + V+ DG
Sbjct: 279 SR-----------SGRLLLAGYDDFNCNIW--DAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 68.9 bits (161), Expect = 4e-11
Identities = 63/291 (21%), Positives = 121/291 (41%), Gaps = 16/291 (5%)
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N+I + G S +T GLD + ++ ++ TL GH + ++ D
Sbjct: 16 NQIRDARKACGDSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 247 IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-- 304
+ K+ I SS + ++P G+ VA GG ++Y +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129
Query: 305 --NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
N V + L ++ + D + I S + + L+D+ G+ H+ V
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD-TTCALWDIETGQQTVGFAGHSGDVM 188
Query: 363 SLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
SL+ +P + S + D + ++++ +S Q + H+ +V F P+G T + D
Sbjct: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVSVSKDKSINIYE 469
+ R+ L + L + H +I+CG V F+ G L++ D + NI++
Sbjct: 249 TCRLFDLRADQELLMY-SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
>BC010073-1|AAH10073.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 2 protein.
Length = 340
Score = 101 bits (243), Expect = 4e-21
Identities = 52/194 (26%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+ + +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
+GH+ V+S++ +PDG+ FVSG+ D ++++WD+ C+ TF H + V
Sbjct: 174 GQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVA 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFTTGSDD 247
Score = 78.2 bits (184), Expect = 6e-14
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L +PDG+ +SG+ I ++ V Q +VA+ P+G +G+
Sbjct: 186 DVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +++W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 64/305 (20%), Positives = 125/305 (40%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D ++ L + +E N +V + + + S + + I+
Sbjct: 110 NFVACGGLDNICSIYSLKT-------REGNVRV-SRELPGHTGYL---SCCRFLDDNQII 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + GH V+S++++PDG T
Sbjct: 159 TSSGDTTCALWDIETGQQTV--GFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ + F P+G TG ++ + + ++ + I S
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 70.1 bits (164), Expect = 2e-11
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ GH+ + SL +PD + ++G+ D +KL+DV +
Sbjct: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T GH S + +VAF P+G F +GS D T R++DL + Q + H++ + G+ A
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIICGITSVAF 278
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
S S ++ G D +W + K + L GH+ V + V+ DG
Sbjct: 279 SR-----------SGRLLLAGYDDFNCNIW--DAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 68.9 bits (161), Expect = 4e-11
Identities = 63/291 (21%), Positives = 121/291 (41%), Gaps = 16/291 (5%)
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N+I + G S +T GLD + ++ ++ TL GH + ++ D
Sbjct: 16 NQIRDARKACGDSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 247 IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-- 304
+ K+ I SS + ++P G+ VA GG ++Y +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129
Query: 305 --NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
N V + L ++ + D + I S + + L+D+ G+ H+ V
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD-TTCALWDIETGQQTVGFAGHSGDVM 188
Query: 363 SLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
SL+ +P + S + D + ++++ +S Q + H+ +V F P+G T + D
Sbjct: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVSVSKDKSINIYE 469
+ R+ L + L + H +I+CG V F+ G L++ D + NI++
Sbjct: 249 TCRLFDLRADQELLMY-SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
>AF501883-1|AAM15919.1| 340|Homo sapiens guanine nucleotide binding
protein beta 2 protein.
Length = 340
Score = 101 bits (243), Expect = 4e-21
Identities = 52/194 (26%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+ + +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
+GH+ V+S++ +PDG+ FVSG+ D ++++WD+ C+ TF H + V
Sbjct: 174 GQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVA 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFTTGSDD 247
Score = 78.2 bits (184), Expect = 6e-14
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L +PDG+ +SG+ I ++ V Q +VA+ P+G +G+
Sbjct: 186 DVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +++W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 64/305 (20%), Positives = 125/305 (40%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D ++ L + +E N +V + + + S + + I+
Sbjct: 110 NFVACGGLDNICSIYSLKT-------REGNVRV-SRELPGHTGYL---SCCRFLDDNQII 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + GH V+S++++PDG T
Sbjct: 159 TSSGDTTCALWDIETGQQTV--GFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ + F P+G TG ++ + + ++ + I S
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 70.1 bits (164), Expect = 2e-11
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ GH+ + SL +PD + ++G+ D +KL+DV +
Sbjct: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T GH S + +VAF P+G F +GS D T R++DL + Q + H++ + G+ A
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIICGITSVAF 278
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
S S ++ G D +W + K + L GH+ V + V+ DG
Sbjct: 279 SR-----------SGRLLLAGYDDFNCNIW--DAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 68.9 bits (161), Expect = 4e-11
Identities = 63/291 (21%), Positives = 121/291 (41%), Gaps = 16/291 (5%)
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N+I + G S +T GLD + ++ ++ TL GH + ++ D
Sbjct: 16 NQIRDARKACGDSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 247 IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-- 304
+ K+ I SS + ++P G+ VA GG ++Y +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129
Query: 305 --NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
N V + L ++ + D + I S + + L+D+ G+ H+ V
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD-TTCALWDIETGQQTVGFAGHSGDVM 188
Query: 363 SLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
SL+ +P + S + D + ++++ +S Q + H+ +V F P+G T + D
Sbjct: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVSVSKDKSINIYE 469
+ R+ L + L + H +I+CG V F+ G L++ D + NI++
Sbjct: 249 TCRLFDLRADQELLMY-SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
>AF053356-4|AAC78794.1| 340|Homo sapiens GNB2 protein.
Length = 340
Score = 101 bits (243), Expect = 4e-21
Identities = 52/194 (26%), Positives = 100/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+ + +G ++ L GH + F D+Q ++T S D L+D+
Sbjct: 115 GGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
+GH+ V+S++ +PDG+ FVSG+ D ++++WD+ C+ TF H + V
Sbjct: 174 GQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVA 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFTTGSDD 247
Score = 78.2 bits (184), Expect = 6e-14
Identities = 44/155 (28%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L +PDG+ +SG+ I ++ V Q +VA+ P+G +G+
Sbjct: 186 DVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +++W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 76.6 bits (180), Expect = 2e-13
Identities = 64/305 (20%), Positives = 125/305 (40%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D ++ L + +E N +V + + + S + + I+
Sbjct: 110 NFVACGGLDNICSIYSLKT-------REGNVRV-SRELPGHTGYL---SCCRFLDDNQII 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + GH V+S++++PDG T
Sbjct: 159 TSSGDTTCALWDIETGQQTV--GFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDS 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ + F P+G TG ++ + + ++ + I S
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 70.1 bits (164), Expect = 2e-11
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G V G N I G + G LS D I +
Sbjct: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ GH+ + SL +PD + ++G+ D +KL+DV +
Sbjct: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T GH S + +VAF P+G F +GS D T R++DL + Q + H++ + G+ A
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIICGITSVAF 278
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
S S ++ G D +W + K + L GH+ V + V+ DG
Sbjct: 279 SR-----------SGRLLLAGYDDFNCNIW--DAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
Query: 246 TIA 248
+A
Sbjct: 326 AVA 328
Score = 68.9 bits (161), Expect = 4e-11
Identities = 63/291 (21%), Positives = 121/291 (41%), Gaps = 16/291 (5%)
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N+I + G S +T GLD + ++ ++ TL GH + ++ D
Sbjct: 16 NQIRDARKACGDSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 247 IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-- 304
+ K+ I SS + ++P G+ VA GG ++Y +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 129
Query: 305 --NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
N V + L ++ + D + I S + + L+D+ G+ H+ V
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD-TTCALWDIETGQQTVGFAGHSGDVM 188
Query: 363 SLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
SL+ +P + S + D + ++++ +S Q + H+ +V F P+G T + D
Sbjct: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVSVSKDKSINIYE 469
+ R+ L + L + H +I+CG V F+ G L++ D + NI++
Sbjct: 249 TCRLFDLRADQELLMY-SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
>BC119693-1|AAI19694.1| 441|Homo sapiens WDR51A protein protein.
Length = 441
Score = 99 bits (238), Expect = 2e-20
Identities = 70/299 (23%), Positives = 126/299 (42%), Gaps = 16/299 (5%)
Query: 87 EGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKR 146
+GH ++ + FS +++ L +GS D + ++ + + A +GH V V FSP G
Sbjct: 50 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 109
Query: 147 FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTG 206
SGS D+TVR+W + F+ H V V F ++ ++ S+DK
Sbjct: 110 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK---------- 159
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK 266
VKVW+ K L +L H V SPDG I +
Sbjct: 160 ----TVKVWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 213
Query: 267 IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSP 326
+ + + F P G+ +A G V V+ + + + + +++ P
Sbjct: 214 VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 273
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVY 385
G Y+ + + ++ + D+ +G++L+T+ H ++AFS + AS +D V V+
Sbjct: 274 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 332
Score = 99.1 bits (236), Expect = 3e-20
Identities = 68/246 (27%), Positives = 113/246 (45%), Gaps = 17/246 (6%)
Query: 4 TGLTDVWT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG D T ++FSP G + SGS + I+ + V SV + DG+
Sbjct: 92 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 151
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ + D + ++ + K + +L H +R FSPD +L+++ SDD +KL+D
Sbjct: 152 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 211
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
+ H +V V F P G + D TV+VWD+ + + ++ H+ V G+ F
Sbjct: 212 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 271
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
+ PS +Y++T D+ +K+ + LL+TL GH+ P +VA S
Sbjct: 272 H--------------PSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFSR 315
Query: 243 DGETIA 248
GE A
Sbjct: 316 TGEYFA 321
Score = 92.7 bits (220), Expect = 3e-18
Identities = 70/290 (24%), Positives = 124/290 (42%), Gaps = 16/290 (5%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V +S + K +ASG++D + ++ + + GH ++ + FSP LL +GS D
Sbjct: 59 VDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 118
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
++++ + H + V SV F DG+ FV+ S D+TV+VW + + +H
Sbjct: 119 VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH 178
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V KF+ + I+S S+DK VK+W + + E +H+ H
Sbjct: 179 INWVRCAKFSPDGRLIVSASDDK--------------TVKLW--DKSSRECVHSYCEHGG 222
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V V P G IA + ++ Q S+ + + F P G+ + T
Sbjct: 223 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITAS 282
Query: 294 HTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
+ + ++ G + L +VA+S G Y ASG V ++
Sbjct: 283 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 332
Score = 92.7 bits (220), Expect = 3e-18
Identities = 46/146 (31%), Positives = 74/146 (50%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S+ + ++ S + G F V + P G IA+ +D +
Sbjct: 187 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 246
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV +L+ + H+ ++ L F P L+T S D +K+ D++ L TL GH
Sbjct: 247 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG 306
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW 159
+VAFS G+ F SG +D V VW
Sbjct: 307 PATTVAFSRTGEYFASGGSDEQVMVW 332
Score = 85.0 bits (201), Expect = 5e-16
Identities = 60/268 (22%), Positives = 111/268 (41%), Gaps = 3/268 (1%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+ +G +D+ + VW + T GH+ V V SP G +A
Sbjct: 68 LASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN 125
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
+ + ++ + + F DG T V V+ L ++
Sbjct: 126 VKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 185
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+SPDGR I S ++ +V L+D S + +H+ H V + F P +A+A D V
Sbjct: 186 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 245
Query: 383 NVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT 441
V+++ + LQ+ H + F P G + T+++D +++++ L E R+L+T H
Sbjct: 246 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQ 305
Query: 442 HIVCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ G S D+ + +++
Sbjct: 306 GPATTVAFSRTGEYFASGGSDEQVMVWK 333
Score = 83.8 bits (198), Expect = 1e-15
Identities = 72/297 (24%), Positives = 117/297 (39%), Gaps = 17/297 (5%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
GH V V FS + K+ SGS D + VW + + F H D V V F+
Sbjct: 51 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS------ 104
Query: 190 ISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAX 249
PS + +G D V++W N K E H V SV DG++
Sbjct: 105 --------PSGHLLASGSRDKTVRIW-VPNVKGEST-VFRAHTATVRSVHFCSDGQSFVT 154
Query: 250 XXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD 309
+ + + + + FSPDG + + V ++ +
Sbjct: 155 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 214
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPK 369
G F+ V + P G IA+ +V ++DV ++L + H+ AV L+F P
Sbjct: 215 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 274
Query: 370 TKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
L +AS+D + + ++ E L H+ A +V FS G+ A+ +D + V
Sbjct: 275 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 331
Score = 66.5 bits (155), Expect = 2e-10
Identities = 42/196 (21%), Positives = 82/196 (41%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F V ++ F DG+ ++ S+ + ++ K L + +SPDG
Sbjct: 132 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 191
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+ I S + D + ++D + + VH+ H + + F P + D +K++DV
Sbjct: 192 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 251
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
L H++ V ++F P G ++ S+D T+++ DL + +T H V
Sbjct: 252 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 311
Query: 181 KFNAESNKIISVSEDK 196
F+ S D+
Sbjct: 312 AFSRTGEYFASGGSDE 327
Score = 64.9 bits (151), Expect = 6e-10
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 3/153 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V +S + + +ASG+ + ++ + + H AV + FSP LLAS S
Sbjct: 56 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 115
Query: 379 DGYVNVY--NIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D V ++ N++ + + H SV F DGQ T++ D +++V + L +
Sbjct: 116 DKTVRIWVPNVKGESTVFRA-HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS 174
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H + V +F+ DG +VS S DK++ +++
Sbjct: 175 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 207
Score = 50.4 bits (115), Expect = 1e-05
Identities = 22/106 (20%), Positives = 49/106 (46%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
+DF P G + + + ++ V + + Q +++ P G Y+ + + D
Sbjct: 227 VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 286
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
+ I D+ +G+L++TL GH ++ FS + +G D + ++
Sbjct: 287 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 332
>BC119692-1|AAI19693.1| 407|Homo sapiens WD repeat domain 51A
protein.
Length = 407
Score = 99 bits (238), Expect = 2e-20
Identities = 70/299 (23%), Positives = 126/299 (42%), Gaps = 16/299 (5%)
Query: 87 EGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKR 146
+GH ++ + FS +++ L +GS D + ++ + + A +GH V V FSP G
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 147 FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTG 206
SGS D+TVR+W + F+ H V V F ++ ++ S+DK
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK---------- 125
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK 266
VKVW+ K L +L H V SPDG I +
Sbjct: 126 ----TVKVWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 267 IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSP 326
+ + + F P G+ +A G V V+ + + + + +++ P
Sbjct: 180 VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 239
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVY 385
G Y+ + + ++ + D+ +G++L+T+ H ++AFS + AS +D V V+
Sbjct: 240 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 99.1 bits (236), Expect = 3e-20
Identities = 68/246 (27%), Positives = 113/246 (45%), Gaps = 17/246 (6%)
Query: 4 TGLTDVWT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG D T ++FSP G + SGS + I+ + V SV + DG+
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ + D + ++ + K + +L H +R FSPD +L+++ SDD +KL+D
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
+ H +V V F P G + D TV+VWD+ + + ++ H+ V G+ F
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
+ PS +Y++T D+ +K+ + LL+TL GH+ P +VA S
Sbjct: 238 H--------------PSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFSR 281
Query: 243 DGETIA 248
GE A
Sbjct: 282 TGEYFA 287
Score = 92.7 bits (220), Expect = 3e-18
Identities = 70/290 (24%), Positives = 124/290 (42%), Gaps = 16/290 (5%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V +S + K +ASG++D + ++ + + GH ++ + FSP LL +GS D
Sbjct: 25 VDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 84
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
++++ + H + V SV F DG+ FV+ S D+TV+VW + + +H
Sbjct: 85 VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH 144
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V KF+ + I+S S+DK VK+W + + E +H+ H
Sbjct: 145 INWVRCAKFSPDGRLIVSASDDK--------------TVKLW--DKSSRECVHSYCEHGG 188
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V V P G IA + ++ Q S+ + + F P G+ + T
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
Query: 294 HTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
+ + ++ G + L +VA+S G Y ASG V ++
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 92.7 bits (220), Expect = 3e-18
Identities = 46/146 (31%), Positives = 74/146 (50%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S+ + ++ S + G F V + P G IA+ +D +
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 212
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV +L+ + H+ ++ L F P L+T S D +K+ D++ L TL GH
Sbjct: 213 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG 272
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW 159
+VAFS G+ F SG +D V VW
Sbjct: 273 PATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 85.0 bits (201), Expect = 5e-16
Identities = 60/268 (22%), Positives = 111/268 (41%), Gaps = 3/268 (1%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+ +G +D+ + VW + T GH+ V V SP G +A
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN 91
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
+ + ++ + + F DG T V V+ L ++
Sbjct: 92 VKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 151
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+SPDGR I S ++ +V L+D S + +H+ H V + F P +A+A D V
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 211
Query: 383 NVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT 441
V+++ + LQ+ H + F P G + T+++D +++++ L E R+L+T H
Sbjct: 212 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQ 271
Query: 442 HIVCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ G S D+ + +++
Sbjct: 272 GPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 83.8 bits (198), Expect = 1e-15
Identities = 72/297 (24%), Positives = 117/297 (39%), Gaps = 17/297 (5%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
GH V V FS + K+ SGS D + VW + + F H D V V F+
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS------ 70
Query: 190 ISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAX 249
PS + +G D V++W N K E H V SV DG++
Sbjct: 71 --------PSGHLLASGSRDKTVRIW-VPNVKGEST-VFRAHTATVRSVHFCSDGQSFVT 120
Query: 250 XXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD 309
+ + + + + FSPDG + + V ++ +
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPK 369
G F+ V + P G IA+ +V ++DV ++L + H+ AV L+F P
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
Query: 370 TKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
L +AS+D + + ++ E L H+ A +V FS G+ A+ +D + V
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 66.5 bits (155), Expect = 2e-10
Identities = 42/196 (21%), Positives = 82/196 (41%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F V ++ F DG+ ++ S+ + ++ K L + +SPDG
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+ I S + D + ++D + + VH+ H + + F P + D +K++DV
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
L H++ V ++F P G ++ S+D T+++ DL + +T H V
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 181 KFNAESNKIISVSEDK 196
F+ S D+
Sbjct: 278 AFSRTGEYFASGGSDE 293
Score = 64.9 bits (151), Expect = 6e-10
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 3/153 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V +S + + +ASG+ + ++ + + H AV + FSP LLAS S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 379 DGYVNVY--NIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D V ++ N++ + + H SV F DGQ T++ D +++V + L +
Sbjct: 82 DKTVRIWVPNVKGESTVFRA-HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS 140
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H + V +F+ DG +VS S DK++ +++
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Score = 50.4 bits (115), Expect = 1e-05
Identities = 22/106 (20%), Positives = 49/106 (46%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
+DF P G + + + ++ V + + Q +++ P G Y+ + + D
Sbjct: 193 VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
+ I D+ +G+L++TL GH ++ FS + +G D + ++
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>BC110877-1|AAI10878.1| 359|Homo sapiens WDR51A protein protein.
Length = 359
Score = 99 bits (238), Expect = 2e-20
Identities = 70/299 (23%), Positives = 126/299 (42%), Gaps = 16/299 (5%)
Query: 87 EGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKR 146
+GH ++ + FS +++ L +GS D + ++ + + A +GH V V FSP G
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 147 FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTG 206
SGS D+TVR+W + F+ H V V F ++ ++ S+DK
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK---------- 125
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK 266
VKVW+ K L +L H V SPDG I +
Sbjct: 126 ----TVKVWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 267 IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSP 326
+ + + F P G+ +A G V V+ + + + + +++ P
Sbjct: 180 VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 239
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVY 385
G Y+ + + ++ + D+ +G++L+T+ H ++AFS + AS +D V V+
Sbjct: 240 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 99.1 bits (236), Expect = 3e-20
Identities = 68/246 (27%), Positives = 113/246 (45%), Gaps = 17/246 (6%)
Query: 4 TGLTDVWT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG D T ++FSP G + SGS + I+ + V SV + DG+
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ + D + ++ + K + +L H +R FSPD +L+++ SDD +KL+D
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
+ H +V V F P G + D TV+VWD+ + + ++ H+ V G+ F
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
+ PS +Y++T D+ +K+ + LL+TL GH+ P +VA S
Sbjct: 238 H--------------PSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFSR 281
Query: 243 DGETIA 248
GE A
Sbjct: 282 TGEYFA 287
Score = 92.7 bits (220), Expect = 3e-18
Identities = 70/290 (24%), Positives = 124/290 (42%), Gaps = 16/290 (5%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V +S + K +ASG++D + ++ + + GH ++ + FSP LL +GS D
Sbjct: 25 VDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 84
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
++++ + H + V SV F DG+ FV+ S D+TV+VW + + +H
Sbjct: 85 VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH 144
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V KF+ + I+S S+DK VK+W + + E +H+ H
Sbjct: 145 INWVRCAKFSPDGRLIVSASDDK--------------TVKLW--DKSSRECVHSYCEHGG 188
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V V P G IA + ++ Q S+ + + F P G+ + T
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
Query: 294 HTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
+ + ++ G + L +VA+S G Y ASG V ++
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 92.7 bits (220), Expect = 3e-18
Identities = 46/146 (31%), Positives = 74/146 (50%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S+ + ++ S + G F V + P G IA+ +D +
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 212
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV +L+ + H+ ++ L F P L+T S D +K+ D++ L TL GH
Sbjct: 213 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG 272
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW 159
+VAFS G+ F SG +D V VW
Sbjct: 273 PATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 85.0 bits (201), Expect = 5e-16
Identities = 60/268 (22%), Positives = 111/268 (41%), Gaps = 3/268 (1%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+ +G +D+ + VW + T GH+ V V SP G +A
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN 91
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
+ + ++ + + F DG T V V+ L ++
Sbjct: 92 VKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 151
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+SPDGR I S ++ +V L+D S + +H+ H V + F P +A+A D V
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 211
Query: 383 NVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT 441
V+++ + LQ+ H + F P G + T+++D +++++ L E R+L+T H
Sbjct: 212 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQ 271
Query: 442 HIVCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ G S D+ + +++
Sbjct: 272 GPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 83.8 bits (198), Expect = 1e-15
Identities = 72/297 (24%), Positives = 117/297 (39%), Gaps = 17/297 (5%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
GH V V FS + K+ SGS D + VW + + F H D V V F+
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS------ 70
Query: 190 ISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAX 249
PS + +G D V++W N K E H V SV DG++
Sbjct: 71 --------PSGHLLASGSRDKTVRIW-VPNVKGEST-VFRAHTATVRSVHFCSDGQSFVT 120
Query: 250 XXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD 309
+ + + + + FSPDG + + V ++ +
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPK 369
G F+ V + P G IA+ +V ++DV ++L + H+ AV L+F P
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
Query: 370 TKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
L +AS+D + + ++ E L H+ A +V FS G+ A+ +D + V
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 66.5 bits (155), Expect = 2e-10
Identities = 42/196 (21%), Positives = 82/196 (41%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F V ++ F DG+ ++ S+ + ++ K L + +SPDG
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+ I S + D + ++D + + VH+ H + + F P + D +K++DV
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
L H++ V ++F P G ++ S+D T+++ DL + +T H V
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 181 KFNAESNKIISVSEDK 196
F+ S D+
Sbjct: 278 AFSRTGEYFASGGSDE 293
Score = 64.9 bits (151), Expect = 6e-10
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 3/153 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V +S + + +ASG+ + ++ + + H AV + FSP LLAS S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 379 DGYVNVY--NIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D V ++ N++ + + H SV F DGQ T++ D +++V + L +
Sbjct: 82 DKTVRIWVPNVKGESTVFRA-HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS 140
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H + V +F+ DG +VS S DK++ +++
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Score = 50.4 bits (115), Expect = 1e-05
Identities = 22/106 (20%), Positives = 49/106 (46%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
+DF P G + + + ++ V + + Q +++ P G Y+ + + D
Sbjct: 193 VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
+ I D+ +G+L++TL GH ++ FS + +G D + ++
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>BC007417-1|AAH07417.2| 396|Homo sapiens WDR51A protein protein.
Length = 396
Score = 99 bits (238), Expect = 2e-20
Identities = 70/299 (23%), Positives = 126/299 (42%), Gaps = 16/299 (5%)
Query: 87 EGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKR 146
+GH ++ + FS +++ L +GS D + ++ + + A +GH V V FSP G
Sbjct: 5 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 64
Query: 147 FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTG 206
SGS D+TVR+W + F+ H V V F ++ ++ S+DK
Sbjct: 65 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK---------- 114
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK 266
VKVW+ K L +L H V SPDG I +
Sbjct: 115 ----TVKVWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 168
Query: 267 IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSP 326
+ + + F P G+ +A G V V+ + + + + +++ P
Sbjct: 169 VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 228
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVY 385
G Y+ + + ++ + D+ +G++L+T+ H ++AFS + AS +D V V+
Sbjct: 229 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 287
Score = 99.1 bits (236), Expect = 3e-20
Identities = 68/246 (27%), Positives = 113/246 (45%), Gaps = 17/246 (6%)
Query: 4 TGLTDVWT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG D T ++FSP G + SGS + I+ + V SV + DG+
Sbjct: 47 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 106
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ + D + ++ + K + +L H +R FSPD +L+++ SDD +KL+D
Sbjct: 107 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 166
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
+ H +V V F P G + D TV+VWD+ + + ++ H+ V G+ F
Sbjct: 167 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 226
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
+ PS +Y++T D+ +K+ + LL+TL GH+ P +VA S
Sbjct: 227 H--------------PSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFSR 270
Query: 243 DGETIA 248
GE A
Sbjct: 271 TGEYFA 276
Score = 92.7 bits (220), Expect = 3e-18
Identities = 70/290 (24%), Positives = 124/290 (42%), Gaps = 16/290 (5%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V +S + K +ASG++D + ++ + + GH ++ + FSP LL +GS D
Sbjct: 14 VDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 73
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
++++ + H + V SV F DG+ FV+ S D+TV+VW + + +H
Sbjct: 74 VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH 133
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V KF+ + I+S S+DK VK+W + + E +H+ H
Sbjct: 134 INWVRCAKFSPDGRLIVSASDDK--------------TVKLW--DKSSRECVHSYCEHGG 177
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V V P G IA + ++ Q S+ + + F P G+ + T
Sbjct: 178 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITAS 237
Query: 294 HTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
+ + ++ G + L +VA+S G Y ASG V ++
Sbjct: 238 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 287
Score = 92.7 bits (220), Expect = 3e-18
Identities = 46/146 (31%), Positives = 74/146 (50%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S+ + ++ S + G F V + P G IA+ +D +
Sbjct: 142 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 201
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV +L+ + H+ ++ L F P L+T S D +K+ D++ L TL GH
Sbjct: 202 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG 261
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW 159
+VAFS G+ F SG +D V VW
Sbjct: 262 PATTVAFSRTGEYFASGGSDEQVMVW 287
Score = 85.0 bits (201), Expect = 5e-16
Identities = 60/268 (22%), Positives = 111/268 (41%), Gaps = 3/268 (1%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+ +G +D+ + VW + T GH+ V V SP G +A
Sbjct: 23 LASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN 80
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
+ + ++ + + F DG T V V+ L ++
Sbjct: 81 VKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 140
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+SPDGR I S ++ +V L+D S + +H+ H V + F P +A+A D V
Sbjct: 141 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 200
Query: 383 NVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT 441
V+++ + LQ+ H + F P G + T+++D +++++ L E R+L+T H
Sbjct: 201 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQ 260
Query: 442 HIVCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ G S D+ + +++
Sbjct: 261 GPATTVAFSRTGEYFASGGSDEQVMVWK 288
Score = 83.8 bits (198), Expect = 1e-15
Identities = 72/297 (24%), Positives = 117/297 (39%), Gaps = 17/297 (5%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
GH V V FS + K+ SGS D + VW + + F H D V V F+
Sbjct: 6 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS------ 59
Query: 190 ISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAX 249
PS + +G D V++W N K E H V SV DG++
Sbjct: 60 --------PSGHLLASGSRDKTVRIW-VPNVKGEST-VFRAHTATVRSVHFCSDGQSFVT 109
Query: 250 XXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD 309
+ + + + + FSPDG + + V ++ +
Sbjct: 110 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 169
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPK 369
G F+ V + P G IA+ +V ++DV ++L + H+ AV L+F P
Sbjct: 170 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 229
Query: 370 TKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
L +AS+D + + ++ E L H+ A +V FS G+ A+ +D + V
Sbjct: 230 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 286
Score = 66.5 bits (155), Expect = 2e-10
Identities = 42/196 (21%), Positives = 82/196 (41%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F V ++ F DG+ ++ S+ + ++ K L + +SPDG
Sbjct: 87 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 146
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+ I S + D + ++D + + VH+ H + + F P + D +K++DV
Sbjct: 147 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 206
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
L H++ V ++F P G ++ S+D T+++ DL + +T H V
Sbjct: 207 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 266
Query: 181 KFNAESNKIISVSEDK 196
F+ S D+
Sbjct: 267 AFSRTGEYFASGGSDE 282
Score = 64.9 bits (151), Expect = 6e-10
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 3/153 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V +S + + +ASG+ + ++ + + H AV + FSP LLAS S
Sbjct: 11 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 70
Query: 379 DGYVNVY--NIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D V ++ N++ + + H SV F DGQ T++ D +++V + L +
Sbjct: 71 DKTVRIWVPNVKGESTVFRA-HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS 129
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H + V +F+ DG +VS S DK++ +++
Sbjct: 130 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 162
Score = 50.4 bits (115), Expect = 1e-05
Identities = 22/106 (20%), Positives = 49/106 (46%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
+DF P G + + + ++ V + + Q +++ P G Y+ + + D
Sbjct: 182 VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 241
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
+ I D+ +G+L++TL GH ++ FS + +G D + ++
Sbjct: 242 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 287
>BC130473-1|AAI30474.1| 522|Homo sapiens transducin (beta)-like
1Y-linked protein.
Length = 522
Score = 99.5 bits (237), Expect = 2e-20
Identities = 86/364 (23%), Positives = 151/364 (41%), Gaps = 41/364 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL----------SGH---- 131
L GH + ++P S LL +GS D +++++ + G+ GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ DG GS D R+W ++ T +H ++ +K+N + N
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGN---- 289
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
Y+++ G+D +W E H P + V + T A
Sbjct: 290 ----------YVLSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNMTFASCS 336
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
++ Q ++++ I + P G +A+ + ++ +
Sbjct: 337 TDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD 396
Query: 312 LDTRGKFIMSVAWSPDGR---------YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+DV QG HT+ H + V
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP K LAS S D YV+++N +S +L + VC++ G ++ SA+DGS
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGS 516
Query: 423 IRVV 426
+ V+
Sbjct: 517 VCVL 520
Score = 87.0 bits (206), Expect = 1e-16
Identities = 78/360 (21%), Positives = 155/360 (43%), Gaps = 21/360 (5%)
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ---CQHTFKEHNDQVWG 179
N A L GH S V A++P SGS D T R+W+L+ H + G
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ SNK ++ S D + G D ++W+ N L TL H+ P+ ++
Sbjct: 230 --HDVPSNKDVT-SLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALK 283
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
+ G + G+ ++ S+ + + + A+ +
Sbjct: 284 WNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIH 342
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V + K + ++ W P G +AS ++ ++ ++ + Q +H ++AH++
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSK 402
Query: 360 AVRSLAFSP---------KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSP 409
+ ++ +SP + +LASAS D V ++++E + L H+ SV FSP
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP 462
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG+ +A+ + D + + + ++H++ + T + V +NA G K+ + + D S+ + +
Sbjct: 463 DGKYLASGSFDKYVHIWNTQSGSLVHSY-QGTGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 85.4 bits (202), Expect = 4e-16
Identities = 64/293 (21%), Positives = 122/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ DG + GS G I+ E+G L ++ ++ G Y+ S
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAG 295
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + + T
Sbjct: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H + H+ +++ +K++
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP--- 411
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ S + + D+ V++W E HTL H+ PV SVA SPDG+ +
Sbjct: 412 --TGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + Q + ++++ ++ G +V G V V
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCWNARGDKVGASASDGSVCV 519
Score = 66.9 bits (156), Expect = 1e-10
Identities = 66/306 (21%), Positives = 118/306 (38%), Gaps = 28/306 (9%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K S+ ++ DG +A G+ DG I+ G L TL H I +L ++ +L+
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
D ++D H++ L V + + F S S D + V L
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
TF+ H ++V +K++ + S S+D +K+WS + + +H L
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDM--------------TLKIWSMKQDAC--VHDL 397
Query: 229 EGHEMPVVSVAVSPDGET---------IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK 279
+ H + ++ SP G +A G + ++
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGS 339
+ FSPDG +A+G V ++ +G++ G I V W+ G + + A GS
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARGDKVGASASDGS 516
Query: 340 VYLFDV 345
V + D+
Sbjct: 517 VCVLDL 522
Score = 54.8 bits (126), Expect = 6e-07
Identities = 30/97 (30%), Positives = 51/97 (52%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ VE G L + SVA+SPDGKY+ASG+ D ++I++ G L
Sbjct: 427 SASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSL 486
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ +G I +C++ + + DG + + D+
Sbjct: 487 VHSYQGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 522
>BC130471-1|AAI30472.1| 522|Homo sapiens transducin (beta)-like
1Y-linked protein.
Length = 522
Score = 99.5 bits (237), Expect = 2e-20
Identities = 86/364 (23%), Positives = 151/364 (41%), Gaps = 41/364 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL----------SGH---- 131
L GH + ++P S LL +GS D +++++ + G+ GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ DG GS D R+W ++ T +H ++ +K+N + N
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGN---- 289
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
Y+++ G+D +W E H P + V + T A
Sbjct: 290 ----------YVLSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNMTFASCS 336
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
++ Q ++++ I + P G +A+ + ++ +
Sbjct: 337 TDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD 396
Query: 312 LDTRGKFIMSVAWSPDGR---------YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+DV QG HT+ H + V
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP K LAS S D YV+++N +S +L + VC++ G ++ SA+DGS
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGS 516
Query: 423 IRVV 426
+ V+
Sbjct: 517 VCVL 520
Score = 87.0 bits (206), Expect = 1e-16
Identities = 78/360 (21%), Positives = 155/360 (43%), Gaps = 21/360 (5%)
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ---CQHTFKEHNDQVWG 179
N A L GH S V A++P SGS D T R+W+L+ H + G
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ SNK ++ S D + G D ++W+ N L TL H+ P+ ++
Sbjct: 230 --HDVPSNKDVT-SLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALK 283
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
+ G + G+ ++ S+ + + + A+ +
Sbjct: 284 WNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIH 342
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V + K + ++ W P G +AS ++ ++ ++ + Q +H ++AH++
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSK 402
Query: 360 AVRSLAFSP---------KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSP 409
+ ++ +SP + +LASAS D V ++++E + L H+ SV FSP
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP 462
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG+ +A+ + D + + + ++H++ + T + V +NA G K+ + + D S+ + +
Sbjct: 463 DGKYLASGSFDKYVHIWNTQSGSLVHSY-QGTGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 85.4 bits (202), Expect = 4e-16
Identities = 64/293 (21%), Positives = 122/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ DG + GS G I+ E+G L ++ ++ G Y+ S
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAG 295
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + + T
Sbjct: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H + H+ +++ +K++
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP--- 411
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ S + + D+ V++W E HTL H+ PV SVA SPDG+ +
Sbjct: 412 --TGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + Q + ++++ ++ G +V G V V
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCWNARGDKVGASASDGSVCV 519
Score = 66.9 bits (156), Expect = 1e-10
Identities = 66/306 (21%), Positives = 118/306 (38%), Gaps = 28/306 (9%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K S+ ++ DG +A G+ DG I+ G L TL H I +L ++ +L+
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
D ++D H++ L V + + F S S D + V L
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
TF+ H ++V +K++ + S S+D +K+WS + + +H L
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDM--------------TLKIWSMKQDAC--VHDL 397
Query: 229 EGHEMPVVSVAVSPDGET---------IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK 279
+ H + ++ SP G +A G + ++
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGS 339
+ FSPDG +A+G V ++ +G++ G I V W+ G + + A GS
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARGDKVGASASDGS 516
Query: 340 VYLFDV 345
V + D+
Sbjct: 517 VCVLDL 522
Score = 54.8 bits (126), Expect = 6e-07
Identities = 30/97 (30%), Positives = 51/97 (52%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ VE G L + SVA+SPDGKY+ASG+ D ++I++ G L
Sbjct: 427 SASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSL 486
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ +G I +C++ + + DG + + D+
Sbjct: 487 VHSYQGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 522
>AK075289-1|BAC11525.1| 407|Homo sapiens protein ( Homo sapiens
cDNA FLJ90808 fis, clone Y79AA1000777, weakly similar to
VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1. ).
Length = 407
Score = 99.5 bits (237), Expect = 2e-20
Identities = 70/299 (23%), Positives = 126/299 (42%), Gaps = 16/299 (5%)
Query: 87 EGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKR 146
+GH ++ + FS +++ L +GS D + ++ + + A +GH V V FSP G
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 147 FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTG 206
SGS D+TVR+W + F+ H V V F ++ ++ S+DK
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK---------- 125
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK 266
VKVW+ K L +L H V SPDG I +
Sbjct: 126 ----TVKVWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 267 IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSP 326
+ + + F P G+ +A G V V+ + + + + +++ P
Sbjct: 180 VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTYRLLQHYQLHSAAVNGLSFHP 239
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVY 385
G Y+ + + ++ + D+ +G++L+T+ H ++AFS + AS +D V V+
Sbjct: 240 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 99.5 bits (237), Expect = 2e-20
Identities = 68/246 (27%), Positives = 113/246 (45%), Gaps = 17/246 (6%)
Query: 4 TGLTDVWT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG D T ++FSP G + SGS + I+ + V SV + DG+
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+ + D + ++ + K + +L H +R FSPD +L+++ SDD +KL+D
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 177
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
+ H +V V F P G + D TV+VWD+ + + ++ H+ V G+ F
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTYRLLQHYQLHSAAVNGLSF 237
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
+ PS +Y++T D+ +K+ + LL+TL GH+ P +VA S
Sbjct: 238 H--------------PSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFSR 281
Query: 243 DGETIA 248
GE A
Sbjct: 282 TGEYFA 287
Score = 92.3 bits (219), Expect = 3e-18
Identities = 70/290 (24%), Positives = 124/290 (42%), Gaps = 16/290 (5%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V +S + K +ASG++D + ++ + + GH ++ + FSP LL +GS D
Sbjct: 25 VDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 84
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
++++ + H + V SV F DG+ FV+ S D+TV+VW + + +H
Sbjct: 85 VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH 144
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V KF+ + I+S S+DK VK+W + + E +H+ H
Sbjct: 145 INWVRCAKFSPDGRLIVSASDDK--------------TVKLW--DKSSRECVHSYCEHGG 188
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V V P G IA + ++ Q S+ + + F P G+ + T
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTYRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
Query: 294 HTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
+ + ++ G + L +VA+S G Y ASG V ++
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 92.3 bits (219), Expect = 3e-18
Identities = 46/146 (31%), Positives = 74/146 (50%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S+ + ++ S + G F V + P G IA+ +D +
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 212
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV +L+ + H+ ++ L F P L+T S D +K+ D++ L TL GH
Sbjct: 213 VWDVRTYRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG 272
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW 159
+VAFS G+ F SG +D V VW
Sbjct: 273 PATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 85.0 bits (201), Expect = 5e-16
Identities = 60/268 (22%), Positives = 111/268 (41%), Gaps = 3/268 (1%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+ +G +D+ + VW + T GH+ V V SP G +A
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN 91
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
+ + ++ + + F DG T V V+ L ++
Sbjct: 92 VKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 151
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+SPDGR I S ++ +V L+D S + +H+ H V + F P +A+A D V
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 211
Query: 383 NVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHT 441
V+++ + LQ+ H + F P G + T+++D +++++ L E R+L+T H
Sbjct: 212 KVWDVRTYRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQ 271
Query: 442 HIVCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ G S D+ + +++
Sbjct: 272 GPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 83.4 bits (197), Expect = 2e-15
Identities = 72/297 (24%), Positives = 117/297 (39%), Gaps = 17/297 (5%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
GH V V FS + K+ SGS D + VW + + F H D V V F+
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS------ 70
Query: 190 ISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAX 249
PS + +G D V++W N K E H V SV DG++
Sbjct: 71 --------PSGHLLASGSRDKTVRIW-VPNVKGEST-VFRAHTATVRSVHFCSDGQSFVT 120
Query: 250 XXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD 309
+ + + + + FSPDG + + V ++ +
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPK 369
G F+ V + P G IA+ +V ++DV ++L + H+ AV L+F P
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTYRLLQHYQLHSAAVNGLSFHPS 240
Query: 370 TKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
L +AS+D + + ++ E L H+ A +V FS G+ A+ +D + V
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 66.5 bits (155), Expect = 2e-10
Identities = 42/196 (21%), Positives = 82/196 (41%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
+F V ++ F DG+ ++ S+ + ++ K L + +SPDG
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 61 KYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+ I S + D + ++D + + VH+ H + + F P + D +K++DV
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
L H++ V ++F P G ++ S+D T+++ DL + +T H V
Sbjct: 218 TYRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 181 KFNAESNKIISVSEDK 196
F+ S D+
Sbjct: 278 AFSRTGEYFASGGSDE 293
Score = 64.9 bits (151), Expect = 6e-10
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 3/153 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V +S + + +ASG+ + ++ + + H AV + FSP LLAS S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 379 DGYVNVY--NIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D V ++ N++ + + H SV F DGQ T++ D +++V + L +
Sbjct: 82 DKTVRIWVPNVKGESTVFRA-HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS 140
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H + V +F+ DG +VS S DK++ +++
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Score = 50.0 bits (114), Expect = 2e-05
Identities = 22/106 (20%), Positives = 49/106 (46%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
+DF P G + + + ++ V + + Q +++ P G Y+ + + D
Sbjct: 193 VDFHPSGTCIAAAGMDNTVKVWDVRTYRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
+ I D+ +G+L++TL GH ++ FS + +G D + ++
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>AF332222-1|AAK13474.1| 522|Homo sapiens transducin beta-like 1
protein.
Length = 522
Score = 99.5 bits (237), Expect = 2e-20
Identities = 86/364 (23%), Positives = 151/364 (41%), Gaps = 41/364 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL----------SGH---- 131
L GH + ++P S LL +GS D +++++ + G+ GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ DG GS D R+W ++ T +H ++ +K+N + N
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGN---- 289
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
Y+++ G+D +W E H P + V + T A
Sbjct: 290 ----------YVLSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNMTFASCS 336
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
++ Q ++++ I + P G +A+ + ++ +
Sbjct: 337 TDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD 396
Query: 312 LDTRGKFIMSVAWSPDGR---------YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+DV QG HT+ H + V
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP K LAS S D YV+++N +S +L + VC++ G ++ SA+DGS
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGS 516
Query: 423 IRVV 426
+ V+
Sbjct: 517 VCVL 520
Score = 87.0 bits (206), Expect = 1e-16
Identities = 78/360 (21%), Positives = 155/360 (43%), Gaps = 21/360 (5%)
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ---CQHTFKEHNDQVWG 179
N A L GH S V A++P SGS D T R+W+L+ H + G
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ SNK ++ S D + G D ++W+ N L TL H+ P+ ++
Sbjct: 230 --HDVPSNKDVT-SLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALK 283
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
+ G + G+ ++ S+ + + + A+ +
Sbjct: 284 WNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIH 342
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V + K + ++ W P G +AS ++ ++ ++ + Q +H ++AH++
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSK 402
Query: 360 AVRSLAFSP---------KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSP 409
+ ++ +SP + +LASAS D V ++++E + L H+ SV FSP
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP 462
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG+ +A+ + D + + + ++H++ + T + V +NA G K+ + + D S+ + +
Sbjct: 463 DGKYLASGSFDKYVHIWNTQSGSLVHSY-QGTGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 85.4 bits (202), Expect = 4e-16
Identities = 64/293 (21%), Positives = 122/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ DG + GS G I+ E+G L ++ ++ G Y+ S
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAG 295
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + + T
Sbjct: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H + H+ +++ +K++
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP--- 411
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ S + + D+ V++W E HTL H+ PV SVA SPDG+ +
Sbjct: 412 --TGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + Q + ++++ ++ G +V G V V
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCWNARGDKVGASASDGSVCV 519
Score = 66.9 bits (156), Expect = 1e-10
Identities = 66/306 (21%), Positives = 118/306 (38%), Gaps = 28/306 (9%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K S+ ++ DG +A G+ DG I+ G L TL H I +L ++ +L+
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
D ++D H++ L V + + F S S D + V L
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
TF+ H ++V +K++ + S S+D +K+WS + + +H L
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDM--------------TLKIWSMKQDAC--VHDL 397
Query: 229 EGHEMPVVSVAVSPDGET---------IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK 279
+ H + ++ SP G +A G + ++
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGS 339
+ FSPDG +A+G V ++ +G++ G I V W+ G + + A GS
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARGDKVGASASDGS 516
Query: 340 VYLFDV 345
V + D+
Sbjct: 517 VCVLDL 522
Score = 54.8 bits (126), Expect = 6e-07
Identities = 30/97 (30%), Positives = 51/97 (52%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ VE G L + SVA+SPDGKY+ASG+ D ++I++ G L
Sbjct: 427 SASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSL 486
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ +G I +C++ + + DG + + D+
Sbjct: 487 VHSYQGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 522
>AF332221-1|AAK13473.1| 522|Homo sapiens transducin beta-like 1
protein.
Length = 522
Score = 99.5 bits (237), Expect = 2e-20
Identities = 86/364 (23%), Positives = 151/364 (41%), Gaps = 41/364 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL----------SGH---- 131
L GH + ++P S LL +GS D +++++ + G+ GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ DG GS D R+W ++ T +H ++ +K+N + N
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGN---- 289
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
Y+++ G+D +W E H P + V + T A
Sbjct: 290 ----------YVLSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNMTFASCS 336
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
++ Q ++++ I + P G +A+ + ++ +
Sbjct: 337 TDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD 396
Query: 312 LDTRGKFIMSVAWSPDGR---------YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+DV QG HT+ H + V
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP K LAS S D YV+++N +S +L + VC++ G ++ SA+DGS
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGS 516
Query: 423 IRVV 426
+ V+
Sbjct: 517 VCVL 520
Score = 87.0 bits (206), Expect = 1e-16
Identities = 78/360 (21%), Positives = 155/360 (43%), Gaps = 21/360 (5%)
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ---CQHTFKEHNDQVWG 179
N A L GH S V A++P SGS D T R+W+L+ H + G
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ SNK ++ S D + G D ++W+ N L TL H+ P+ ++
Sbjct: 230 --HDVPSNKDVT-SLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALK 283
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
+ G + G+ ++ S+ + + + A+ +
Sbjct: 284 WNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIH 342
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V + K + ++ W P G +AS ++ ++ ++ + Q +H ++AH++
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSK 402
Query: 360 AVRSLAFSP---------KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSP 409
+ ++ +SP + +LASAS D V ++++E + L H+ SV FSP
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP 462
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG+ +A+ + D + + + ++H++ + T + V +NA G K+ + + D S+ + +
Sbjct: 463 DGKYLASGSFDKYVHIWNTQSGSLVHSY-QGTGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 85.4 bits (202), Expect = 4e-16
Identities = 64/293 (21%), Positives = 122/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ DG + GS G I+ E+G L ++ ++ G Y+ S
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAG 295
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + + T
Sbjct: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H + H+ +++ +K++
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP--- 411
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ S + + D+ V++W E HTL H+ PV SVA SPDG+ +
Sbjct: 412 --TGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + Q + ++++ ++ G +V G V V
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCWNARGDKVGASASDGSVCV 519
Score = 66.9 bits (156), Expect = 1e-10
Identities = 66/306 (21%), Positives = 118/306 (38%), Gaps = 28/306 (9%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K S+ ++ DG +A G+ DG I+ G L TL H I +L ++ +L+
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
D ++D H++ L V + + F S S D + V L
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
TF+ H ++V +K++ + S S+D +K+WS + + +H L
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDM--------------TLKIWSMKQDAC--VHDL 397
Query: 229 EGHEMPVVSVAVSPDGET---------IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK 279
+ H + ++ SP G +A G + ++
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGS 339
+ FSPDG +A+G V ++ +G++ G I V W+ G + + A GS
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARGDKVGASASDGS 516
Query: 340 VYLFDV 345
V + D+
Sbjct: 517 VCVLDL 522
Score = 54.8 bits (126), Expect = 6e-07
Identities = 30/97 (30%), Positives = 51/97 (52%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ VE G L + SVA+SPDGKY+ASG+ D ++I++ G L
Sbjct: 427 SASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSL 486
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ +G I +C++ + + DG + + D+
Sbjct: 487 VHSYQGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 522
>AF332220-1|AAK13472.1| 522|Homo sapiens transducin beta-like 1
protein.
Length = 522
Score = 99.5 bits (237), Expect = 2e-20
Identities = 86/364 (23%), Positives = 151/364 (41%), Gaps = 41/364 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL----------SGH---- 131
L GH + ++P S LL +GS D +++++ + G+ GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ DG GS D R+W ++ T +H ++ +K+N + N
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGN---- 289
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
Y+++ G+D +W E H P + V + T A
Sbjct: 290 ----------YVLSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNMTFASCS 336
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
++ Q ++++ I + P G +A+ + ++ +
Sbjct: 337 TDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD 396
Query: 312 LDTRGKFIMSVAWSPDGR---------YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+DV QG HT+ H + V
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP K LAS S D YV+++N +S +L + VC++ G ++ SA+DGS
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGS 516
Query: 423 IRVV 426
+ V+
Sbjct: 517 VCVL 520
Score = 87.0 bits (206), Expect = 1e-16
Identities = 78/360 (21%), Positives = 155/360 (43%), Gaps = 21/360 (5%)
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ---CQHTFKEHNDQVWG 179
N A L GH S V A++P SGS D T R+W+L+ H + G
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ SNK ++ S D + G D ++W+ N L TL H+ P+ ++
Sbjct: 230 --HDVPSNKDVT-SLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALK 283
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
+ G + G+ ++ S+ + + + A+ +
Sbjct: 284 WNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIH 342
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V + K + ++ W P G +AS ++ ++ ++ + Q +H ++AH++
Sbjct: 343 VCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSK 402
Query: 360 AVRSLAFSP---------KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSP 409
+ ++ +SP + +LASAS D V ++++E + L H+ SV FSP
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP 462
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG+ +A+ + D + + + ++H++ + T + V +NA G K+ + + D S+ + +
Sbjct: 463 DGKYLASGSFDKYVHIWNTQSGSLVHSY-QGTGGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 85.4 bits (202), Expect = 4e-16
Identities = 64/293 (21%), Positives = 122/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ DG + GS G I+ E+G L ++ ++ G Y+ S
Sbjct: 237 DVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAG 295
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + + T
Sbjct: 296 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H + H+ +++ +K++
Sbjct: 355 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP--- 411
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ S + + D+ V++W E HTL H+ PV SVA SPDG+ +
Sbjct: 412 --TGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + Q + ++++ ++ G +V G V V
Sbjct: 468 ASGSFDKYVHIWNTQSGSLVHSYQ-GTGGIFEVCWNARGDKVGASASDGSVCV 519
Score = 66.9 bits (156), Expect = 1e-10
Identities = 66/306 (21%), Positives = 118/306 (38%), Gaps = 28/306 (9%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K S+ ++ DG +A G+ DG I+ G L TL H I +L ++ +L+
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
D ++D H++ L V + + F S S D + V L
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVK 353
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
TF+ H ++V +K++ + S S+D +K+WS + + +H L
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDM--------------TLKIWSMKQDAC--VHDL 397
Query: 229 EGHEMPVVSVAVSPDGET---------IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK 279
+ H + ++ SP G +A G + ++
Sbjct: 398 QAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYS 457
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGS 339
+ FSPDG +A+G V ++ +G++ G I V W+ G + + A GS
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG-IFEVCWNARGDKVGASASDGS 516
Query: 340 VYLFDV 345
V + D+
Sbjct: 517 VCVLDL 522
Score = 54.8 bits (126), Expect = 6e-07
Identities = 30/97 (30%), Positives = 51/97 (52%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ VE G L + SVA+SPDGKY+ASG+ D ++I++ G L
Sbjct: 427 SASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSL 486
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ +G I +C++ + + DG + + D+
Sbjct: 487 VHSYQGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 522
>AK001667-1|BAA91822.1| 513|Homo sapiens protein ( Homo sapiens
cDNA FLJ10805 fis, clone NT2RP4000839, weakly similar to
VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1. ).
Length = 513
Score = 98.7 bits (235), Expect = 4e-20
Identities = 72/297 (24%), Positives = 133/297 (44%), Gaps = 16/297 (5%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGK--------FTLSVAYSPDGKYIAS 65
FSPDG+++++GS G I ++ +GK + L + + L + +S D + +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 66 GALDGIINIFDVAQGKLVHTLE-GHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
GA DG I ++ + G+ + E H+ + L FS DS +L+ S D ++++ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
GH+S+V F+ DG +S S+D TV++W++ + +C +TFK G
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTA-GTDITV 400
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
N +I + K P ++ V N V + + + + + + V A+SP G
Sbjct: 401 --NSVILL--PKNP--EHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRG 454
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
E I G+ R + D+ I P + +AT G + ++
Sbjct: 455 EWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNPIATYSEDGLLKLW 511
Score = 73.7 bits (173), Expect = 1e-12
Identities = 42/155 (27%), Positives = 81/155 (52%), Gaps = 10/155 (6%)
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ--------AVRSLAFSPKTKLLAS 375
+SPDG+Y+ +G+ G + +++ + GK+ ++ AQ AV + FS T++LA+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 376 ASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ DG + V+ I+S + + H + FS D ++ +++ D +IR+ L+ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
L F H+ V F DG ++S S D ++ I+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
Score = 71.3 bits (167), Expect = 7e-12
Identities = 74/312 (23%), Positives = 128/312 (41%), Gaps = 18/312 (5%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA--------SWV 135
H G + FSPD Q L+TGS DG +++++ + L A V
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF-KEHNDQVWGVKFNAESNKIISVSE 194
L + FS D + +G+ D ++VW + S QC F + H+ V + F+ +S++I+S S
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 195 DKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXX 254
D+ + +G L + + + E T +GH + ++ S DG
Sbjct: 328 DQTIRIHGLKSG--KTLKEFRGHSSFVNEATFTQDGHYI----ISASSDGTVKIWNMKTT 381
Query: 255 XXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKV-TVYGIINGTVDKVLD 313
G T +S + + +P+ V +T + + G I +
Sbjct: 382 ECSNTFKSLGSTAGTDITVNS-VILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKR 440
Query: 314 TRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G F+ A SP G +I E +Y F GK+ T+ H + V +A P +
Sbjct: 441 EGGDFV-CCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNPI 499
Query: 374 ASASNDGYVNVY 385
A+ S DG + ++
Sbjct: 500 ATYSEDGLLKLW 511
Score = 70.9 bits (166), Expect = 9e-12
Identities = 43/167 (25%), Positives = 85/167 (50%), Gaps = 10/167 (5%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKFIMS------VAWSPDGRYIAS 333
FSPDG + TG G + V+ G + K L + F+M + +S D +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 334 GAEGGSVYLFDVSQGKMLHTIE-AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-A 391
GA+ G + ++ + G+ L E AH++ V L+FS + + SAS D + ++ ++S
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 392 LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ H + F+ DG + ++++DG++++ ++ +TF+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFK 388
Score = 58.8 bits (136), Expect = 4e-08
Identities = 36/124 (29%), Positives = 66/124 (53%), Gaps = 13/124 (10%)
Query: 355 EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCW---------AVSV 405
++H + R FSP + L + S DG++ V+N + ++ L ++ + +
Sbjct: 214 KSHVECAR---FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 270
Query: 406 CFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE-HTHIVCGVQFNADGSKLVSVSKDKS 464
CFS D + +AT A DG I+V ++ + L FE H+ V + F+ D S+++S S D++
Sbjct: 271 CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQT 330
Query: 465 INIY 468
I I+
Sbjct: 331 IRIH 334
Score = 56.0 bits (129), Expect = 3e-07
Identities = 39/178 (21%), Positives = 75/178 (42%), Gaps = 9/178 (5%)
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV---- 281
H G + V SPDG+ + G+ ++++ + D + ++
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 282 ----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLD-TRGKFIMSVAWSPDGRYIASGAE 336
FS D +ATG GK+ V+ I +G + + K + +++S D I S +
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQN 394
++ + + GK L H+ V F+ + SAS+DG V ++N+++ N
Sbjct: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385
Score = 48.4 bits (110), Expect = 6e-05
Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 11/197 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V L FS D ++S S I I G++SGK + F ++ DG YI S +
Sbjct: 310 VTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASS 369
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHM---KLYDVVHANLA 125
DG + I+++ + +T + S + +S +LL + + + + VV N+
Sbjct: 370 DGTVKIWNMKTTECSNTFKSLG-STAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ 428
Query: 126 GTL-----SG--HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVW 178
G + SG + A SP G+ D + + + + + T H V
Sbjct: 429 GQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI 488
Query: 179 GVKFNAESNKIISVSED 195
G+ + N I + SED
Sbjct: 489 GIAHHPHQNPIATYSED 505
>AJ243048-1|CAB55588.1| 1248|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1248
Score = 98.7 bits (235), Expect = 4e-20
Identities = 91/415 (21%), Positives = 169/415 (40%), Gaps = 11/415 (2%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + + ++ E ++I
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV-KQFFLNLEDPQEDMEVIV 801
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
I+ + + + + L +HT GH + SP
Sbjct: 802 KCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHT--GHHSTIQYCDFSPQNHLAVVAL 859
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
K+ + + S + ++FSPDGS T + ++ V K
Sbjct: 860 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKN 917
Query: 312 LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK 371
K + V + + + + + L + G++ + EA V SP +
Sbjct: 918 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQ 974
Query: 372 LLASASNDGYVNVYN-IESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+A +G + + + + Q++ HK + F+ D + + +S+ D I+V
Sbjct: 975 YIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1029
Score = 92.7 bits (220), Expect = 3e-18
Identities = 93/418 (22%), Positives = 171/418 (40%), Gaps = 15/418 (3%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMK 115
+S DG+ IAS D + +F G+ + ++ H + FS D + + T S D +K
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 116 LYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV--SGSADRTVRVWDLDSMQCQHTFKEH 173
+++ + L T H+ V F+ + +GS+D +++WDL+ +C++T H
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V +F+ + + S S D G K + T N K + + L L E E+
Sbjct: 743 TNSVNHCRFSPDDKLLASCSAD-GTLKLWDATSA--NERKSINVKQFFLNLEDPQEDMEV 799
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDS-SDMWKIVFSPDGSQVATG 292
V + S DG I G + EI T S + FSP
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGL-LGEIHTGHHSTIQYCDFSPQNHLAVVA 858
Query: 293 GHTGKVTVYGIINGTVDKVLDTRG--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM 350
V ++ + KV D RG ++ V +SPDG + ++ ++ L++ K+
Sbjct: 859 LSQYCVELWN--TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KV 914
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPD 410
+ + F ++ + + + + N + + + + C SP
Sbjct: 915 CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPH 972
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +A +G+I ++ L R+ + +H V +QF AD L+S S D I ++
Sbjct: 973 LQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 1030
Score = 92.3 bits (219), Expect = 3e-18
Identities = 102/454 (22%), Positives = 187/454 (41%), Gaps = 59/454 (12%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSV--------------AYSPD 59
FSPD K + S S G + ++ S + + ++ + +F L++ ++S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSAD 809
Query: 60 GKYIASGALDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
G I A + I +FD+ G L GH +I+ FSP + L + ++L++
Sbjct: 810 GARIMVAAKNKIF-LFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWN 868
Query: 119 VVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT--------- 169
+ GH SWV V FSPDG F++ S D+T+R+W+ + C+++
Sbjct: 869 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVD 927
Query: 170 --FKEHNDQVWGVK-------FNAESNKIISVSEDK------GPSKDYIVTGGLDNLVKV 214
F+E+ V V N + +I ++E + P YI G + +++
Sbjct: 928 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 987
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI--REIQT 272
NN++ + H+ V + + D +T+ + I R Q
Sbjct: 988 LELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQE 1045
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
D + S++ + G V V+ II G +K ++S S D +
Sbjct: 1046 TVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFS 1101
Query: 333 SGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL 392
S + + ++ LH + H VR AFS + LLA+ ++G + ++N+ + L
Sbjct: 1102 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1161
Query: 393 ---------QNKLDHKCWAVSVCFSPDGQRMATS 417
+ H W +CFSPDG+ + ++
Sbjct: 1162 LHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1195
Score = 76.2 bits (179), Expect = 2e-13
Identities = 96/460 (20%), Positives = 182/460 (39%), Gaps = 17/460 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI--ASGALDGI 71
FS D + + + S K+ I+ +G+ D + ++ ++ A+G+ D
Sbjct: 665 FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ ++D+ Q + +T+ GH S+ FSPD +LL + S DG +KL+D AN +++
Sbjct: 725 LKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 784
Query: 132 ASWVLSVAFSPDGKRFV---SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
++ D + V S SAD R+ + + F H + G + + +
Sbjct: 785 QFFLNLEDPQEDMEVIVKCCSWSADGA-RIM-VAAKNKIFLFDIHTSGLLG-EIHTGHHS 841
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
I D P V V++W+ ++ + GH V V SPDG +
Sbjct: 842 TIQYC-DFSPQNHLAVVALSQYCVELWNTDSRSK--VADCRGHLSWVHGVMFSPDGSSFL 898
Query: 249 XXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV 308
K + +VF + V H ++ + G +
Sbjct: 899 TSSDDQTIRLWETKKVCKNSAVMLKQEV--DVVFQENEVMVLAVDHIRRLQLINGRTGQI 956
Query: 309 DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP 368
D + + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 957 DYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA 1013
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 1014 DEKTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNI 1072
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1073 ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1112
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 970 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1029
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 1030 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1087
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1146
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1147 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1196
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1197 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1239
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 890 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 945
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 946 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 1002
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 1003 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1060
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1061 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1104
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1105 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1164
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1165 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1222
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1223 IHVSPDFKTYVTVDNLGILYI 1243
Score = 66.1 bits (154), Expect = 3e-10
Identities = 64/311 (20%), Positives = 121/311 (38%), Gaps = 29/311 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDT 314
I + DM IV +S DG+++ K+ ++ I +G + ++
Sbjct: 780 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTG 838
Query: 315 RGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLA 374
I +SP V L++ + H V + FSP
Sbjct: 839 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 898
Query: 375 SASNDGYVNVY 385
++S+D + ++
Sbjct: 899 TSSDDQTIRLW 909
Score = 62.9 bits (146), Expect = 2e-09
Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 2/171 (1%)
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H V S DG+ IA G+K+ EI+ ++ FS D +A
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 291 TGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYI--ASGAEGGSVYLFDVSQG 348
T KV ++ + G + D + + ++ ++ A+G+ + L+D++Q
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHK 399
+ +T+ H +V FSP KLLAS S DG + +++ SA + ++ K
Sbjct: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 784
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 970 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1029
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 1030 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1087
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1147
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1148 NGEIRIW 1154
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1179 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1236
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1237 NL-GILYILQTLE 1248
>AJ243009-1|CAB55585.1| 1248|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1248
Score = 98.7 bits (235), Expect = 4e-20
Identities = 91/415 (21%), Positives = 169/415 (40%), Gaps = 11/415 (2%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + + ++ E ++I
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV-KQFFLNLEDPQEDMEVIV 801
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
I+ + + + + L +HT GH + SP
Sbjct: 802 KCCSWSADGARIMVAAKNKIFLFAIHTSGLLGEIHT--GHHSTIQYCDFSPQNHLAVVAL 859
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
K+ + + S + ++FSPDGS T + ++ V K
Sbjct: 860 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKN 917
Query: 312 LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK 371
K + V + + + + + L + G++ + EA V SP +
Sbjct: 918 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLVNGRTGQIDYLTEAQ---VSCCCLSPHLQ 974
Query: 372 LLASASNDGYVNVYN-IESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+A +G + + + + Q++ HK + F+ D + + +S+ D I+V
Sbjct: 975 YIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1029
Score = 93.1 bits (221), Expect = 2e-18
Identities = 93/418 (22%), Positives = 171/418 (40%), Gaps = 15/418 (3%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMK 115
+S DG+ IAS D + +F G+ + ++ H + FS D + + T S D +K
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 116 LYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV--SGSADRTVRVWDLDSMQCQHTFKEH 173
+++ + L T H+ V F+ + +GS+D +++WDL+ +C++T H
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V +F+ + + S S D G K + T N K + + L L E E+
Sbjct: 743 TNSVNHCRFSPDDKLLASCSAD-GTLKLWDATSA--NERKSINVKQFFLNLEDPQEDMEV 799
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDS-SDMWKIVFSPDGSQVATG 292
V + S DG I G + EI T S + FSP
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLFAIHTSGL-LGEIHTGHHSTIQYCDFSPQNHLAVVA 858
Query: 293 GHTGKVTVYGIINGTVDKVLDTRG--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM 350
V ++ + KV D RG ++ V +SPDG + ++ ++ L++ K+
Sbjct: 859 LSQYCVELWN--TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KV 914
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPD 410
+ + F ++ + + + + N + + + + C SP
Sbjct: 915 CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLVNGRTGQIDYLTEAQ--VSCCCLSPH 972
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +A +G+I ++ L R+ + +H V +QF AD L+S S D I ++
Sbjct: 973 LQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 1030
Score = 89.4 bits (212), Expect = 2e-17
Identities = 100/453 (22%), Positives = 183/453 (40%), Gaps = 57/453 (12%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSV--------------AYSPD 59
FSPD K + S S G + ++ S + + ++ + +F L++ ++S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSAD 809
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
G I A + I G L GH +I+ FSP + L + ++L++
Sbjct: 810 GARIMVAAKNKIFLFAIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNT 869
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT---------- 169
+ GH SWV V FSPDG F++ S D+T+R+W+ + C+++
Sbjct: 870 DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDV 928
Query: 170 -FKEHNDQVWGVKF-------NAESNKIISVSEDK------GPSKDYIVTGGLDNLVKVW 215
F+E+ V V N + +I ++E + P YI G + +++
Sbjct: 929 VFQENEVMVLAVDHIRRLQLVNGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEIL 988
Query: 216 SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI--REIQTD 273
NN++ + H+ V + + D +T+ + I R Q
Sbjct: 989 ELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQET 1046
Query: 274 SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIAS 333
D + S++ + G V V+ II G +K ++S S D +S
Sbjct: 1047 VKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSS 1102
Query: 334 GAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL- 392
+ + ++ LH + H VR AFS + LLA+ ++G + ++N+ + L
Sbjct: 1103 TSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1162
Query: 393 --------QNKLDHKCWAVSVCFSPDGQRMATS 417
+ H W +CFSPDG+ + ++
Sbjct: 1163 HLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1195
Score = 76.2 bits (179), Expect = 2e-13
Identities = 96/460 (20%), Positives = 182/460 (39%), Gaps = 17/460 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI--ASGALDGI 71
FS D + + + S K+ I+ +G+ D + ++ ++ A+G+ D
Sbjct: 665 FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ ++D+ Q + +T+ GH S+ FSPD +LL + S DG +KL+D AN +++
Sbjct: 725 LKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 784
Query: 132 ASWVLSVAFSPDGKRFV---SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
++ D + V S SAD R+ + + F H + G + + +
Sbjct: 785 QFFLNLEDPQEDMEVIVKCCSWSADGA-RIM-VAAKNKIFLFAIHTSGLLG-EIHTGHHS 841
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
I D P V V++W+ ++ + GH V V SPDG +
Sbjct: 842 TIQYC-DFSPQNHLAVVALSQYCVELWNTDSRSK--VADCRGHLSWVHGVMFSPDGSSFL 898
Query: 249 XXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV 308
K + +VF + V H ++ + G +
Sbjct: 899 TSSDDQTIRLWETKKVCKNSAVMLKQEV--DVVFQENEVMVLAVDHIRRLQLVNGRTGQI 956
Query: 309 DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP 368
D + + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 957 DYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA 1013
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 1014 DEKTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNI 1072
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1073 ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1112
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 970 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1029
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 1030 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1087
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1146
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1147 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1196
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1197 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1239
Score = 70.1 bits (164), Expect = 2e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 890 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 945
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 946 LQLVNGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 1002
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 1003 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1060
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1061 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1104
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1105 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1164
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1165 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1222
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1223 IHVSPDFKTYVTVDNLGILYI 1243
Score = 66.5 bits (155), Expect = 2e-10
Identities = 64/311 (20%), Positives = 121/311 (38%), Gaps = 29/311 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDT 314
I + DM IV +S DG+++ K+ ++ I +G + ++
Sbjct: 780 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFAIHTSGLLGEIHTG 838
Query: 315 RGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLA 374
I +SP V L++ + H V + FSP
Sbjct: 839 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 898
Query: 375 SASNDGYVNVY 385
++S+D + ++
Sbjct: 899 TSSDDQTIRLW 909
Score = 62.9 bits (146), Expect = 2e-09
Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 2/171 (1%)
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H V S DG+ IA G+K+ EI+ ++ FS D +A
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 291 TGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYI--ASGAEGGSVYLFDVSQG 348
T KV ++ + G + D + + ++ ++ A+G+ + L+D++Q
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHK 399
+ +T+ H +V FSP KLLAS S DG + +++ SA + ++ K
Sbjct: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 784
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 970 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1029
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 1030 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1087
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1147
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1148 NGEIRIW 1154
Score = 41.9 bits (94), Expect = 0.005
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSCLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1179 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1236
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1237 NL-GILYILQTLE 1248
>AF149794-1|AAD34016.1| 1248|Homo sapiens apoptotic protease
activating factor 1 protein.
Length = 1248
Score = 98.7 bits (235), Expect = 4e-20
Identities = 91/415 (21%), Positives = 169/415 (40%), Gaps = 11/415 (2%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + + ++ E ++I
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV-KQFFLNLEDPQEDMEVIV 801
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
I+ + + + + L +HT GH + SP
Sbjct: 802 KCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHT--GHHSTIQYCDFSPQNHLAVVAL 859
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
K+ + + S + ++FSPDGS T + ++ V K
Sbjct: 860 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKN 917
Query: 312 LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK 371
K + V + + + + + L + G++ + EA V SP +
Sbjct: 918 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQ 974
Query: 372 LLASASNDGYVNVYN-IESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+A +G + + + + Q++ HK + F+ D + + +S+ D I+V
Sbjct: 975 YIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1029
Score = 92.7 bits (220), Expect = 3e-18
Identities = 93/418 (22%), Positives = 171/418 (40%), Gaps = 15/418 (3%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMK 115
+S DG+ IAS D + +F G+ + ++ H + FS D + + T S D +K
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 116 LYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV--SGSADRTVRVWDLDSMQCQHTFKEH 173
+++ + L T H+ V F+ + +GS+D +++WDL+ +C++T H
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V +F+ + + S S D G K + T N K + + L L E E+
Sbjct: 743 TNSVNHCRFSPDDKLLASCSAD-GTLKLWDATSA--NERKSINVKQFFLNLEDPQEDMEV 799
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDS-SDMWKIVFSPDGSQVATG 292
V + S DG I G + EI T S + FSP
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGL-LGEIHTGHHSTIQYCDFSPQNHLAVVA 858
Query: 293 GHTGKVTVYGIINGTVDKVLDTRG--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM 350
V ++ + KV D RG ++ V +SPDG + ++ ++ L++ K+
Sbjct: 859 LSQYCVELWN--TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KV 914
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPD 410
+ + F ++ + + + + N + + + + C SP
Sbjct: 915 CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPH 972
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +A +G+I ++ L R+ + +H V +QF AD L+S S D I ++
Sbjct: 973 LQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 1030
Score = 92.3 bits (219), Expect = 3e-18
Identities = 102/454 (22%), Positives = 187/454 (41%), Gaps = 59/454 (12%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSV--------------AYSPD 59
FSPD K + S S G + ++ S + + ++ + +F L++ ++S D
Sbjct: 751 FSPDDKLLASCSADGTLKLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSAD 809
Query: 60 GKYIASGALDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
G I A + I +FD+ G L GH +I+ FSP + L + ++L++
Sbjct: 810 GARIMVAAKNKIF-LFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWN 868
Query: 119 VVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT--------- 169
+ GH SWV V FSPDG F++ S D+T+R+W+ + C+++
Sbjct: 869 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVD 927
Query: 170 --FKEHNDQVWGVK-------FNAESNKIISVSEDK------GPSKDYIVTGGLDNLVKV 214
F+E+ V V N + +I ++E + P YI G + +++
Sbjct: 928 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 987
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI--REIQT 272
NN++ + H+ V + + D +T+ + I R Q
Sbjct: 988 LELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQE 1045
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
D + S++ + G V V+ II G +K ++S S D +
Sbjct: 1046 TVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFS 1101
Query: 333 SGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL 392
S + + ++ LH + H VR AFS + LLA+ ++G + ++N+ + L
Sbjct: 1102 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1161
Query: 393 ---------QNKLDHKCWAVSVCFSPDGQRMATS 417
+ H W +CFSPDG+ + ++
Sbjct: 1162 LHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1195
Score = 76.2 bits (179), Expect = 2e-13
Identities = 96/460 (20%), Positives = 182/460 (39%), Gaps = 17/460 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI--ASGALDGI 71
FS D + + + S K+ I+ +G+ D + ++ ++ A+G+ D
Sbjct: 665 FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ ++D+ Q + +T+ GH S+ FSPD +LL + S DG +KL+D AN +++
Sbjct: 725 LKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 784
Query: 132 ASWVLSVAFSPDGKRFV---SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
++ D + V S SAD R+ + + F H + G + + +
Sbjct: 785 QFFLNLEDPQEDMEVIVKCCSWSADGA-RIM-VAAKNKIFLFDIHTSGLLG-EIHTGHHS 841
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
I D P V V++W+ ++ + GH V V SPDG +
Sbjct: 842 TIQYC-DFSPQNHLAVVALSQYCVELWNTDSRSK--VADCRGHLSWVHGVMFSPDGSSFL 898
Query: 249 XXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV 308
K + +VF + V H ++ + G +
Sbjct: 899 TSSDDQTIRLWETKKVCKNSAVMLKQEV--DVVFQENEVMVLAVDHIRRLQLINGRTGQI 956
Query: 309 DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP 368
D + + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 957 DYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA 1013
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 1014 DEKTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNI 1072
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1073 ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1112
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 970 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1029
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 1030 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1087
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1146
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1147 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1196
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1197 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1239
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 890 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 945
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 946 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 1002
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 1003 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1060
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1061 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1104
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1105 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1164
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1165 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1222
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1223 IHVSPDFKTYVTVDNLGILYI 1243
Score = 66.1 bits (154), Expect = 3e-10
Identities = 64/311 (20%), Positives = 121/311 (38%), Gaps = 29/311 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 721
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 722 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 779
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDT 314
I + DM IV +S DG+++ K+ ++ I +G + ++
Sbjct: 780 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTG 838
Query: 315 RGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLA 374
I +SP V L++ + H V + FSP
Sbjct: 839 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 898
Query: 375 SASNDGYVNVY 385
++S+D + ++
Sbjct: 899 TSSDDQTIRLW 909
Score = 62.9 bits (146), Expect = 2e-09
Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 2/171 (1%)
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H V S DG+ IA G+K+ EI+ ++ FS D +A
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 291 TGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYI--ASGAEGGSVYLFDVSQG 348
T KV ++ + G + D + + ++ ++ A+G+ + L+D++Q
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHK 399
+ +T+ H +V FSP KLLAS S DG + +++ SA + ++ K
Sbjct: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 784
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 618 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 677
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 678 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 970 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1029
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 1030 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1087
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1147
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1148 NGEIRIW 1154
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 597 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 656
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIW 684
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1179 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1236
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1237 NL-GILYILQTLE 1248
>AF134397-1|AAD38344.1| 1237|Homo sapiens apoptotic protease
activating factor-1 long isoform APAF-1L protein.
Length = 1237
Score = 98.7 bits (235), Expect = 4e-20
Identities = 91/415 (21%), Positives = 169/415 (40%), Gaps = 11/415 (2%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + + ++ E ++I
Sbjct: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV-KQFFLNLEDPQEDMEVIV 790
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
I+ + + + + L +HT GH + SP
Sbjct: 791 KCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHT--GHHSTIQYCDFSPQNHLAVVAL 848
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
K+ + + S + ++FSPDGS T + ++ V K
Sbjct: 849 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKN 906
Query: 312 LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK 371
K + V + + + + + L + G++ + EA V SP +
Sbjct: 907 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQ 963
Query: 372 LLASASNDGYVNVYN-IESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+A +G + + + + Q++ HK + F+ D + + +S+ D I+V
Sbjct: 964 YIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1018
Score = 92.7 bits (220), Expect = 3e-18
Identities = 93/418 (22%), Positives = 171/418 (40%), Gaps = 15/418 (3%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMK 115
+S DG+ IAS D + +F G+ + ++ H + FS D + + T S D +K
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 116 LYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV--SGSADRTVRVWDLDSMQCQHTFKEH 173
+++ + L T H+ V F+ + +GS+D +++WDL+ +C++T H
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V +F+ + + S S D G K + T N K + + L L E E+
Sbjct: 732 TNSVNHCRFSPDDKLLASCSAD-GTLKLWDATSA--NERKSINVKQFFLNLEDPQEDMEV 788
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDS-SDMWKIVFSPDGSQVATG 292
V + S DG I G + EI T S + FSP
Sbjct: 789 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGL-LGEIHTGHHSTIQYCDFSPQNHLAVVA 847
Query: 293 GHTGKVTVYGIINGTVDKVLDTRG--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM 350
V ++ + KV D RG ++ V +SPDG + ++ ++ L++ K+
Sbjct: 848 LSQYCVELWN--TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KV 903
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPD 410
+ + F ++ + + + + N + + + + C SP
Sbjct: 904 CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPH 961
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +A +G+I ++ L R+ + +H V +QF AD L+S S D I ++
Sbjct: 962 LQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 1019
Score = 92.3 bits (219), Expect = 3e-18
Identities = 102/454 (22%), Positives = 187/454 (41%), Gaps = 59/454 (12%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSV--------------AYSPD 59
FSPD K + S S G + ++ S + + ++ + +F L++ ++S D
Sbjct: 740 FSPDDKLLASCSADGTLKLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSAD 798
Query: 60 GKYIASGALDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
G I A + I +FD+ G L GH +I+ FSP + L + ++L++
Sbjct: 799 GARIMVAAKNKIF-LFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWN 857
Query: 119 VVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT--------- 169
+ GH SWV V FSPDG F++ S D+T+R+W+ + C+++
Sbjct: 858 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVD 916
Query: 170 --FKEHNDQVWGVK-------FNAESNKIISVSEDK------GPSKDYIVTGGLDNLVKV 214
F+E+ V V N + +I ++E + P YI G + +++
Sbjct: 917 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 976
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI--REIQT 272
NN++ + H+ V + + D +T+ + I R Q
Sbjct: 977 LELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQE 1034
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
D + S++ + G V V+ II G +K ++S S D +
Sbjct: 1035 TVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFS 1090
Query: 333 SGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL 392
S + + ++ LH + H VR AFS + LLA+ ++G + ++N+ + L
Sbjct: 1091 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1150
Query: 393 ---------QNKLDHKCWAVSVCFSPDGQRMATS 417
+ H W +CFSPDG+ + ++
Sbjct: 1151 LHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1184
Score = 76.2 bits (179), Expect = 2e-13
Identities = 96/460 (20%), Positives = 182/460 (39%), Gaps = 17/460 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI--ASGALDGI 71
FS D + + + S K+ I+ +G+ D + ++ ++ A+G+ D
Sbjct: 654 FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 713
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ ++D+ Q + +T+ GH S+ FSPD +LL + S DG +KL+D AN +++
Sbjct: 714 LKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 773
Query: 132 ASWVLSVAFSPDGKRFV---SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
++ D + V S SAD R+ + + F H + G + + +
Sbjct: 774 QFFLNLEDPQEDMEVIVKCCSWSADGA-RIM-VAAKNKIFLFDIHTSGLLG-EIHTGHHS 830
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
I D P V V++W+ ++ + GH V V SPDG +
Sbjct: 831 TIQYC-DFSPQNHLAVVALSQYCVELWNTDSRSK--VADCRGHLSWVHGVMFSPDGSSFL 887
Query: 249 XXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV 308
K + +VF + V H ++ + G +
Sbjct: 888 TSSDDQTIRLWETKKVCKNSAVMLKQEV--DVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
Query: 309 DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP 368
D + + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 946 DYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA 1002
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 1003 DEKTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNI 1061
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1062 ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1101
Score = 72.9 bits (171), Expect = 2e-12
Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 14/283 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 959 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1018
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 1019 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1135
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1136 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1185
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
G+ + T+ +++ KI SPD T + G
Sbjct: 1186 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLG 1228
Score = 70.5 bits (165), Expect = 1e-11
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 879 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 934
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 935 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 991
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 992 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1049
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1050 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1093
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1094 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1153
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1154 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1211
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1212 IHVSPDFKTYVTVDNLGILYI 1232
Score = 66.1 bits (154), Expect = 3e-10
Identities = 64/311 (20%), Positives = 121/311 (38%), Gaps = 29/311 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 710
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 711 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 768
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDT 314
I + DM IV +S DG+++ K+ ++ I +G + ++
Sbjct: 769 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTG 827
Query: 315 RGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLA 374
I +SP V L++ + H V + FSP
Sbjct: 828 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 887
Query: 375 SASNDGYVNVY 385
++S+D + ++
Sbjct: 888 TSSDDQTIRLW 898
Score = 62.9 bits (146), Expect = 2e-09
Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 2/171 (1%)
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H V S DG+ IA G+K+ EI+ ++ FS D +A
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 291 TGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYI--ASGAEGGSVYLFDVSQG 348
T KV ++ + G + D + + ++ ++ A+G+ + L+D++Q
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHK 399
+ +T+ H +V FSP KLLAS S DG + +++ SA + ++ K
Sbjct: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 773
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 607 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 666
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 667 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 726
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 959 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1018
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 1019 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1136
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1137 NGEIRIW 1143
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 586 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 645
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 646 EDEVLCCAFSTDDRFIATCSVDKKVKIW 673
Score = 33.1 bits (72), Expect = 2.2
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1168 WVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1225
Query: 67 ALDGIINIFDVAQ 79
L GI+ I +
Sbjct: 1226 NL-GILYILQTLE 1237
>AF052432-1|AAC09328.1| 655|Homo sapiens katanin p80 subunit
protein.
Length = 655
Score = 98.7 bits (235), Expect = 4e-20
Identities = 53/175 (30%), Positives = 90/175 (51%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+++GS +G I ++ +E+ K + L S+ + P G+++ASG+ D I ++D+ +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGLKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
V GH+ ++R L FSPD + L + +DD +KL+D+ + GH V V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
P+ SGS+D T+R WDL+ Q + V V FN + + S +D
Sbjct: 198 HPNEYLLASGSSDGTIRFWDLEKFQVVSRIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Score = 88.2 bits (209), Expect = 6e-17
Identities = 54/181 (29%), Positives = 97/181 (53%), Gaps = 2/181 (1%)
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+ G +G + V+ + + + L I S+ + P G ++ASG++ ++ L+D+ +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGLKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-F 407
+ H+QAVR L FSP K LASA++D V ++++ + + ++ V+V F
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
P+ +A+ ++DG+IR LE+F+V+ E V V FN DG L S +D S+ +
Sbjct: 198 HPNEYLLASGSSDGTIRFWDLEKFQVVSRIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRV 256
Query: 468 Y 468
Y
Sbjct: 257 Y 257
Score = 87.4 bits (207), Expect = 1e-16
Identities = 57/264 (21%), Positives = 118/264 (44%), Gaps = 17/264 (6%)
Query: 39 KQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF 98
K ++++ + V G+ +A+G D +N++ + + + +L GH + S+
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 99 SPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRV 158
+ +L++ GS G ++++D+ A + TL G + + S+ F P G+ SGS D +++
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGLKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 159 WDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE 218
WD+ C ++ H+ V ++F+ + + S ++ D+ VK+W
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAAD--------------DHTVKLWDLT 177
Query: 219 NNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
K ++ GH PV V P+ +A Q + I+ + +
Sbjct: 178 AGK--MMSEFPGHTGPVNVVEFHPNEYLLASGSSDGTIRFWDLEKFQVVSRIEGEPGPVR 235
Query: 279 KIVFSPDGSQVATGGHTGKVTVYG 302
++F+PDG + +G + VYG
Sbjct: 236 SVLFNPDGCCLYSGCQ-DSLRVYG 258
Score = 86.2 bits (204), Expect = 2e-16
Identities = 50/161 (31%), Positives = 86/161 (53%), Gaps = 5/161 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIAS 65
++ +LDF P G+ V SGS I ++ + ++ V RG + + +SPDGK++AS
Sbjct: 107 NICSLDFHPYGEFVASGSQDTNIKLWDIR--RKGCVFRYRGHSQAVRCLRFSPDGKWLAS 164
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
A D + ++D+ GK++ GH + + F P+ LL +GS DG ++ +D+ +
Sbjct: 165 AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDGTIRFWDLEKFQVV 224
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQC 166
+ G V SV F+PDG SG D ++RV+ + +C
Sbjct: 225 SRIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
Score = 81.0 bits (191), Expect = 8e-15
Identities = 62/249 (24%), Positives = 108/249 (43%), Gaps = 17/249 (6%)
Query: 89 HAMSIRSLCFSPDS-QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRF 147
HA ++ SL S +LL TG DD + L+ + N +L+GH S V SV + +
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 148 VSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGG 207
V+GS ++RVWDL++ + T + G+K N S D P +++ +G
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRT-------LMGLKANI-------CSLDFHPYGEFVASGS 124
Query: 208 LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI 267
D +K+W + GH V + SPDG+ +A G+ +
Sbjct: 125 QDTNIKLWDIRRKGCVFRY--RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMM 182
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
E + + + F P+ +A+G G + + + V ++ + SV ++PD
Sbjct: 183 SEFPGHTGPVNVVEFHPNEYLLASGSSDGTIRFWDLEKFQVVSRIEGEPGPVRSVLFNPD 242
Query: 328 GRYIASGAE 336
G + SG +
Sbjct: 243 GCCLYSGCQ 251
Score = 73.3 bits (172), Expect = 2e-12
Identities = 54/206 (26%), Positives = 101/206 (49%), Gaps = 2/206 (0%)
Query: 266 KIREIQTDSSDMWKIVFSP-DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAW 324
K++EI +S++ +V G +ATGG +V ++ I L + SV
Sbjct: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 325 SPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNV 384
+ I +G++ GS+ ++D+ K+L T+ + SL F P + +AS S D + +
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGLKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 385 YNIESAALQNKLDHKCWAV-SVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
++I + AV + FSPDG+ +A++A D ++++ L +++ F HT
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V V+F+ + L S S D +I ++
Sbjct: 192 VNVVEFHPNEYLLASGSSDGTIRFWD 217
>AB007873-1|BAA24843.2| 1237|Homo sapiens KIAA0413 protein.
Length = 1237
Score = 98.7 bits (235), Expect = 4e-20
Identities = 91/415 (21%), Positives = 169/415 (40%), Gaps = 11/415 (2%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FS DG+ + S + +F E+G++ + L A+S D ++IA+ ++D +
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANLAGTLSGH 131
I++ G+LVHT + H+ + F+ S LL TGS D +KL+D+ T+ GH
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
+ V FSPD K S SAD T+++WD S + + ++ E ++I
Sbjct: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV-KQFFLNLEDPQEDMEVIV 790
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
I+ + + + + L +HT GH + SP
Sbjct: 791 KCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHT--GHHSTIQYCDFSPQNHLAVVAL 848
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
K+ + + S + ++FSPDGS T + ++ V K
Sbjct: 849 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKN 906
Query: 312 LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK 371
K + V + + + + + L + G++ + EA V SP +
Sbjct: 907 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQ 963
Query: 372 LLASASNDGYVNVYN-IESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+A +G + + + + Q++ HK + F+ D + + +S+ D I+V
Sbjct: 964 YIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1018
Score = 92.7 bits (220), Expect = 3e-18
Identities = 93/418 (22%), Positives = 171/418 (40%), Gaps = 15/418 (3%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMK 115
+S DG+ IAS D + +F G+ + ++ H + FS D + + T S D +K
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 116 LYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV--SGSADRTVRVWDLDSMQCQHTFKEH 173
+++ + L T H+ V F+ + +GS+D +++WDL+ +C++T H
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V +F+ + + S S D G K + T N K + + L L E E+
Sbjct: 732 TNSVNHCRFSPDDKLLASCSAD-GTLKLWDATSA--NERKSINVKQFFLNLEDPQEDMEV 788
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDS-SDMWKIVFSPDGSQVATG 292
V + S DG I G + EI T S + FSP
Sbjct: 789 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGL-LGEIHTGHHSTIQYCDFSPQNHLAVVA 847
Query: 293 GHTGKVTVYGIINGTVDKVLDTRG--KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM 350
V ++ + KV D RG ++ V +SPDG + ++ ++ L++ K+
Sbjct: 848 LSQYCVELWN--TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KV 903
Query: 351 LHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPD 410
+ + F ++ + + + + N + + + + C SP
Sbjct: 904 CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQ--VSCCCLSPH 961
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +A +G+I ++ L R+ + +H V +QF AD L+S S D I ++
Sbjct: 962 LQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 1019
Score = 92.3 bits (219), Expect = 3e-18
Identities = 102/454 (22%), Positives = 187/454 (41%), Gaps = 59/454 (12%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSV--------------AYSPD 59
FSPD K + S S G + ++ S + + ++ + +F L++ ++S D
Sbjct: 740 FSPDDKLLASCSADGTLKLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSAD 798
Query: 60 GKYIASGALDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
G I A + I +FD+ G L GH +I+ FSP + L + ++L++
Sbjct: 799 GARIMVAAKNKIF-LFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWN 857
Query: 119 VVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT--------- 169
+ GH SWV V FSPDG F++ S D+T+R+W+ + C+++
Sbjct: 858 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVD 916
Query: 170 --FKEHNDQVWGVK-------FNAESNKIISVSEDK------GPSKDYIVTGGLDNLVKV 214
F+E+ V V N + +I ++E + P YI G + +++
Sbjct: 917 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 976
Query: 215 WSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI--REIQT 272
NN++ + H+ V + + D +T+ + I R Q
Sbjct: 977 LELVNNRI--FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQE 1034
Query: 273 DSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA 332
D + S++ + G V V+ II G +K ++S S D +
Sbjct: 1035 TVKDFRLL----KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFS 1090
Query: 333 SGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL 392
S + + ++ LH + H VR AFS + LLA+ ++G + ++N+ + L
Sbjct: 1091 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1150
Query: 393 ---------QNKLDHKCWAVSVCFSPDGQRMATS 417
+ H W +CFSPDG+ + ++
Sbjct: 1151 LHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1184
Score = 76.2 bits (179), Expect = 2e-13
Identities = 96/460 (20%), Positives = 182/460 (39%), Gaps = 17/460 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI--ASGALDGI 71
FS D + + + S K+ I+ +G+ D + ++ ++ A+G+ D
Sbjct: 654 FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 713
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ ++D+ Q + +T+ GH S+ FSPD +LL + S DG +KL+D AN +++
Sbjct: 714 LKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 773
Query: 132 ASWVLSVAFSPDGKRFV---SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
++ D + V S SAD R+ + + F H + G + + +
Sbjct: 774 QFFLNLEDPQEDMEVIVKCCSWSADGA-RIM-VAAKNKIFLFDIHTSGLLG-EIHTGHHS 830
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
I D P V V++W+ ++ + GH V V SPDG +
Sbjct: 831 TIQYC-DFSPQNHLAVVALSQYCVELWNTDSRSK--VADCRGHLSWVHGVMFSPDGSSFL 887
Query: 249 XXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV 308
K + +VF + V H ++ + G +
Sbjct: 888 TSSDDQTIRLWETKKVCKNSAVMLKQEV--DVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
Query: 309 DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSP 368
D + + + + SP +YIA G E G++ + ++ ++ + H + V + F+
Sbjct: 946 DYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA 1002
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLL 428
K L S+S+D + V+N + H+ V R+ + + DG+++V +
Sbjct: 1003 DEKTLISSSDDAEIQVWNWQLDKCIFLRGHQ-ETVKDFRLLKNSRLLSWSFDGTVKVWNI 1061
Query: 429 EEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
F H V + D +K S S DK+ I+
Sbjct: 1062 ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1101
Score = 73.3 bits (172), Expect = 2e-12
Identities = 68/287 (23%), Positives = 123/287 (42%), Gaps = 14/287 (4%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SP +++ G G I I + + + Q K + ++ D K + S + D I +
Sbjct: 959 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1018
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
++ K + L GH +++ +S+LL + S DG +K+++++ N H
Sbjct: 1019 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
VLS S D +F S SAD+T ++W D + H + HN V F+ +S +++ +
Sbjct: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-LLATGD 1135
Query: 195 DKGPSKDYIVTGG-LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXX 253
D G + + V+ G L +L S E H V + SPDG+ +
Sbjct: 1136 DNGEIRIWNVSNGELLHLCAPLSEEG--------AATHGGWVTDLCFSPDGKML--ISAG 1185
Query: 254 XXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
G+ + T+ +++ KI SPD T + G + +
Sbjct: 1186 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGIIYI 1232
Score = 71.3 bits (167), Expect = 7e-12
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 37/381 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI-- 71
FSPDG ++ S+ I ++ E+ K + K + V + + + A+D I
Sbjct: 879 FSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMVL--AVDHIRR 934
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ + + G++ + E + C SP Q + G ++G +++ ++V+ + + H
Sbjct: 935 LQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 991
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V + F+ D K +S S D ++VW+ +C + H + V + ++++++S
Sbjct: 992 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRL-LKNSRLLS 1049
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
S D VKVW+ E H+ V+S +S D +
Sbjct: 1050 WS--------------FDGTVKVWNIITGNKE--KDFVCHQGTVLSCDISHDATKFSSTS 1093
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV--- 308
+ E++ + + FS D + +ATG G++ ++ + NG +
Sbjct: 1094 ADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL 1153
Query: 309 -----DKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
++ T G ++ + +SPDG+ + S GG + ++V G+ T + ++
Sbjct: 1154 CAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYTNGTNLKK 1211
Query: 364 LAFSPKTKLLASASNDGYVNV 384
+ SP K + N G + +
Sbjct: 1212 IHVSPDFKTYVTVDNLGIIYI 1232
Score = 66.1 bits (154), Expect = 3e-10
Identities = 64/311 (20%), Positives = 121/311 (38%), Gaps = 29/311 (9%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H ++ CFS D Q + + D ++++ + H VL AFS D +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ S D+ V++W+ + + HT+ EH++QV F S+ ++ + TG
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL------------LATGSS 710
Query: 209 DNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIR 268
D +K+W + N+ E +T+ GH V SPD + +A + +
Sbjct: 711 DCFLKLW--DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERK 768
Query: 269 EI---------QTDSSDMWKIV----FSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDT 314
I + DM IV +S DG+++ K+ ++ I +G + ++
Sbjct: 769 SINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTG 827
Query: 315 RGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLA 374
I +SP V L++ + H V + FSP
Sbjct: 828 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 887
Query: 375 SASNDGYVNVY 385
++S+D + ++
Sbjct: 888 TSSDDQTIRLW 898
Score = 62.9 bits (146), Expect = 2e-09
Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 2/171 (1%)
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H V S DG+ IA G+K+ EI+ ++ FS D +A
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 291 TGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYI--ASGAEGGSVYLFDVSQG 348
T KV ++ + G + D + + ++ ++ A+G+ + L+D++Q
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHK 399
+ +T+ H +V FSP KLLAS S DG + +++ SA + ++ K
Sbjct: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVK 773
Score = 58.0 bits (134), Expect = 7e-08
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ +S DG+ IAS ++ +F G+ L I+AH V AFS + +A+ S
Sbjct: 607 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 666
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQR---MATSAADGSIRVVLLEEFRVLH 435
D V ++N + L + D V+ C + +AT ++D +++ L + +
Sbjct: 667 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 726
Query: 436 TFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
T HT+ V +F+ D L S S D ++ +++
Sbjct: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/187 (19%), Positives = 82/187 (43%), Gaps = 3/187 (1%)
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
SP +A G G + + ++N + + K + + ++ D + + S ++ + +
Sbjct: 959 SPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV 1018
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNK-LDHKCW 401
++ K + + H + V+ ++LL S S DG V V+NI + + + H+
Sbjct: 1019 WNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
+S S D + ++++AD + ++ + LH H V F+ D + L +
Sbjct: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1136
Query: 462 DKSINIY 468
+ I I+
Sbjct: 1137 NGEIRIW 1143
Score = 41.5 bits (93), Expect = 0.006
Identities = 25/88 (28%), Positives = 40/88 (45%)
Query: 381 YVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEH 440
++N NI + + H CFS DGQR+A+ AD +++V E L + H
Sbjct: 586 WINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH 645
Query: 441 THIVCGVQFNADGSKLVSVSKDKSINIY 468
V F+ D + + S DK + I+
Sbjct: 646 EDEVLCCAFSTDDRFIATCSVDKKVKIW 673
Score = 33.9 bits (74), Expect = 1.3
Identities = 27/73 (36%), Positives = 34/73 (46%), Gaps = 6/73 (8%)
Query: 10 WTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK-YIASG 66
W D FSPDGK +IS G I + V +G+ Q T G + SPD K Y+
Sbjct: 1168 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVD 1225
Query: 67 ALDGIINIFDVAQ 79
L GII I +
Sbjct: 1226 NL-GIIYILQTLE 1237
>U72342-1|AAC51111.1| 410|Homo sapiens platelet activating factor
acetylhydrolase, brain isoform, 45 kDa subunit protein.
Length = 410
Score = 98.3 bits (234), Expect = 5e-20
Identities = 64/240 (26%), Positives = 110/240 (45%), Gaps = 8/240 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P ++S S I ++ E+G E+ L +++ GK +AS + D I
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++D + + T+ GH ++ S+ P+ +++ S D +K+++V T +GH
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV----WGVKFNAESNKI 189
WV V + DG S S D+TVRVW + + +C+ +EH V W + + S
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 190 ISVSEDK--GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ SE K G ++++G D +K+W L TL GH+ V V G+ I
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM--CLMTLVGHDNWVRGVLFHSGGKFI 353
Score = 93.1 bits (221), Expect = 2e-18
Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 39/343 (11%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPD 143
+ L GH + + F P ++++ S+D +K++D + TL GH V ++F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 144 GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYI 203
GK S SAD T+++WD +C T H+ V V P+ D+I
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIM--------------PNGDHI 207
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXX 263
V+ D +K+W + + T GH V V + DG IA
Sbjct: 208 VSASRDKTIKMWEVQTG--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT 265
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
+ E++ + I ++P+ S + TG T GK
Sbjct: 266 KECKAELREHEHVVECISWAPESSYSSISEATGSET-------------KKSGK------ 306
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++ SG+ ++ ++DVS G L T+ H VR + F K + S ++D +
Sbjct: 307 ---PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 384 VYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRV 425
V++ ++ L+ H+ + S+ F + T + D +++V
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 85.0 bits (201), Expect = 5e-16
Identities = 46/143 (32%), Positives = 72/143 (50%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V + P + S + D I ++D G TL+GH S++ + F +LL + S D
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL+D T+ GH V SVA P+G VS S D+T+++W++ + C TF H
Sbjct: 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233
Query: 174 NDQVWGVKFNAESNKIISVSEDK 196
+ V V+ N + I S S D+
Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQ 256
Score = 79.8 bits (188), Expect = 2e-14
Identities = 61/228 (26%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
+V ++ P+G H++S S I ++ V++G + ++ V + DG IAS +
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------------------LLLT 107
D + ++ VA + L H + + ++P+S LL+
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 108 GSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
GS D +K++DV TL GH +WV V F GK +S + D+T+RVWD + +C
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVW 215
T H V + F+ + Y+VTG +D VKVW
Sbjct: 374 KTLNAHEHFVTSLDFHKTA--------------PYVVTGSVDQTVKVW 407
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/294 (19%), Positives = 118/294 (40%), Gaps = 23/294 (7%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P +V+ D +KVW YE E TL+GH V ++ G+ +A
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR + ++ + P+G + + + ++ + G K +
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK------ 371
++ V + DG IAS + +V ++ V+ + + H V ++++P++
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 372 --------------LLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMAT 416
L S S D + ++++ + L + H W V F G+ + +
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
A D ++RV + R + T H H V + F+ +V+ S D+++ ++EC
Sbjct: 356 CADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409
Score = 67.3 bits (157), Expect = 1e-10
Identities = 32/101 (31%), Positives = 57/101 (56%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
G ++ SG+ D I ++DV+ G + TL GH +R + F + +L+ +DD ++++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+ TL+ H +V S+ F V+GS D+TV+VW+
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 60.9 bits (141), Expect = 1e-08
Identities = 32/119 (26%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPD 410
+ + H V + F P ++ SAS D + V++ E+ + L H + F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G+ +A+ +AD +I++ + F + T H H V V +G +VS S+DK+I ++E
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Score = 60.9 bits (141), Expect = 1e-08
Identities = 35/171 (20%), Positives = 78/171 (45%), Gaps = 1/171 (0%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S + +++F P S + + + V+ G ++ L + +++ G+ +AS
Sbjct: 109 SPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASC 168
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQ 393
+ ++ L+D + + T+ H V S+A P + SAS D + ++ +++ ++
Sbjct: 169 SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK 228
Query: 394 NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIV 444
H+ W V + DG +A+ + D ++RV ++ EH H+V
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
Score = 44.8 bits (101), Expect = 7e-04
Identities = 27/101 (26%), Positives = 48/101 (47%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV 77
G ++SGS I ++ V +G L + V + GK+I S A D + ++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ + TL H + SL F + ++TGS D +K+++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>L13386-1|AAA02881.1| 410|Homo sapiens Miller-Dieker lissencephaly
protein protein.
Length = 410
Score = 98.3 bits (234), Expect = 5e-20
Identities = 64/240 (26%), Positives = 110/240 (45%), Gaps = 8/240 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P ++S S I ++ E+G E+ L +++ GK +AS + D I
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++D + + T+ GH ++ S+ P+ +++ S D +K+++V T +GH
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV----WGVKFNAESNKI 189
WV V + DG S S D+TVRVW + + +C+ +EH V W + + S
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 190 ISVSEDK--GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ SE K G ++++G D +K+W L TL GH+ V V G+ I
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM--CLMTLVGHDNWVRGVLFHSGGKFI 353
Score = 93.1 bits (221), Expect = 2e-18
Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 39/343 (11%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPD 143
+ L GH + + F P ++++ S+D +K++D + TL GH V ++F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 144 GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYI 203
GK S SAD T+++WD +C T H+ V V P+ D+I
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIM--------------PNGDHI 207
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXX 263
V+ D +K+W + + T GH V V + DG IA
Sbjct: 208 VSASRDKTIKMWEVQTG--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT 265
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
+ E++ + I ++P+ S + TG T GK
Sbjct: 266 KECKAELREHEHVVECISWAPESSYSSISEATGSET-------------KKSGK------ 306
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++ SG+ ++ ++DVS G L T+ H VR + F K + S ++D +
Sbjct: 307 ---PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 384 VYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRV 425
V++ ++ L+ H+ + S+ F + T + D +++V
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 85.0 bits (201), Expect = 5e-16
Identities = 46/143 (32%), Positives = 72/143 (50%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V + P + S + D I ++D G TL+GH S++ + F +LL + S D
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL+D T+ GH V SVA P+G VS S D+T+++W++ + C TF H
Sbjct: 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233
Query: 174 NDQVWGVKFNAESNKIISVSEDK 196
+ V V+ N + I S S D+
Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQ 256
Score = 79.8 bits (188), Expect = 2e-14
Identities = 61/228 (26%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
+V ++ P+G H++S S I ++ V++G + ++ V + DG IAS +
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------------------LLLT 107
D + ++ VA + L H + + ++P+S LL+
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 108 GSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
GS D +K++DV TL GH +WV V F GK +S + D+T+RVWD + +C
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVW 215
T H V + F+ + Y+VTG +D VKVW
Sbjct: 374 KTLNAHEHFVTSLDFHKTA--------------PYVVTGSVDQTVKVW 407
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/294 (19%), Positives = 118/294 (40%), Gaps = 23/294 (7%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P +V+ D +KVW YE E TL+GH V ++ G+ +A
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR + ++ + P+G + + + ++ + G K +
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK------ 371
++ V + DG IAS + +V ++ V+ + + H V ++++P++
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 372 --------------LLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMAT 416
L S S D + ++++ + L + H W V F G+ + +
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
A D ++RV + R + T H H V + F+ +V+ S D+++ ++EC
Sbjct: 356 CADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409
Score = 67.3 bits (157), Expect = 1e-10
Identities = 32/101 (31%), Positives = 57/101 (56%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
G ++ SG+ D I ++DV+ G + TL GH +R + F + +L+ +DD ++++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+ TL+ H +V S+ F V+GS D+TV+VW+
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 60.9 bits (141), Expect = 1e-08
Identities = 32/119 (26%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPD 410
+ + H V + F P ++ SAS D + V++ E+ + L H + F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G+ +A+ +AD +I++ + F + T H H V V +G +VS S+DK+I ++E
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Score = 60.9 bits (141), Expect = 1e-08
Identities = 35/171 (20%), Positives = 78/171 (45%), Gaps = 1/171 (0%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S + +++F P S + + + V+ G ++ L + +++ G+ +AS
Sbjct: 109 SPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASC 168
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQ 393
+ ++ L+D + + T+ H V S+A P + SAS D + ++ +++ ++
Sbjct: 169 SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK 228
Query: 394 NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIV 444
H+ W V + DG +A+ + D ++RV ++ EH H+V
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
Score = 44.8 bits (101), Expect = 7e-04
Identities = 27/101 (26%), Positives = 48/101 (47%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV 77
G ++SGS I ++ V +G L + V + GK+I S A D + ++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ + TL H + SL F + ++TGS D +K+++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>L13385-1|AAA02880.1| 410|Homo sapiens Miller-Dieker lissencephaly
protein protein.
Length = 410
Score = 98.3 bits (234), Expect = 5e-20
Identities = 64/240 (26%), Positives = 110/240 (45%), Gaps = 8/240 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P ++S S I ++ E+G E+ L +++ GK +AS + D I
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++D + + T+ GH ++ S+ P+ +++ S D +K+++V T +GH
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV----WGVKFNAESNKI 189
WV V + DG S S D+TVRVW + + +C+ +EH V W + + S
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 190 ISVSEDK--GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ SE K G ++++G D +K+W L TL GH+ V V G+ I
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM--CLMTLVGHDNWVRGVLFHSGGKFI 353
Score = 93.1 bits (221), Expect = 2e-18
Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 39/343 (11%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPD 143
+ L GH + + F P ++++ S+D +K++D + TL GH V ++F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 144 GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYI 203
GK S SAD T+++WD +C T H+ V V P+ D+I
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIM--------------PNGDHI 207
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXX 263
V+ D +K+W + + T GH V V + DG IA
Sbjct: 208 VSASRDKTIKMWEVQTG--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT 265
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
+ E++ + I ++P+ S + TG T GK
Sbjct: 266 KECKAELREHEHVVECISWAPESSYSSISEATGSET-------------KKSGK------ 306
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++ SG+ ++ ++DVS G L T+ H VR + F K + S ++D +
Sbjct: 307 ---PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 384 VYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRV 425
V++ ++ L+ H+ + S+ F + T + D +++V
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 85.0 bits (201), Expect = 5e-16
Identities = 46/143 (32%), Positives = 72/143 (50%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V + P + S + D I ++D G TL+GH S++ + F +LL + S D
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL+D T+ GH V SVA P+G VS S D+T+++W++ + C TF H
Sbjct: 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233
Query: 174 NDQVWGVKFNAESNKIISVSEDK 196
+ V V+ N + I S S D+
Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQ 256
Score = 79.8 bits (188), Expect = 2e-14
Identities = 61/228 (26%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
+V ++ P+G H++S S I ++ V++G + ++ V + DG IAS +
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------------------LLLT 107
D + ++ VA + L H + + ++P+S LL+
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 108 GSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
GS D +K++DV TL GH +WV V F GK +S + D+T+RVWD + +C
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVW 215
T H V + F+ + Y+VTG +D VKVW
Sbjct: 374 KTLNAHEHFVTSLDFHKTA--------------PYVVTGSVDQTVKVW 407
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/294 (19%), Positives = 118/294 (40%), Gaps = 23/294 (7%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P +V+ D +KVW YE E TL+GH V ++ G+ +A
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR + ++ + P+G + + + ++ + G K +
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK------ 371
++ V + DG IAS + +V ++ V+ + + H V ++++P++
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 372 --------------LLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMAT 416
L S S D + ++++ + L + H W V F G+ + +
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
A D ++RV + R + T H H V + F+ +V+ S D+++ ++EC
Sbjct: 356 CADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409
Score = 67.3 bits (157), Expect = 1e-10
Identities = 32/101 (31%), Positives = 57/101 (56%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
G ++ SG+ D I ++DV+ G + TL GH +R + F + +L+ +DD ++++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+ TL+ H +V S+ F V+GS D+TV+VW+
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 60.9 bits (141), Expect = 1e-08
Identities = 32/119 (26%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPD 410
+ + H V + F P ++ SAS D + V++ E+ + L H + F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G+ +A+ +AD +I++ + F + T H H V V +G +VS S+DK+I ++E
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Score = 60.9 bits (141), Expect = 1e-08
Identities = 35/171 (20%), Positives = 78/171 (45%), Gaps = 1/171 (0%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S + +++F P S + + + V+ G ++ L + +++ G+ +AS
Sbjct: 109 SPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASC 168
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQ 393
+ ++ L+D + + T+ H V S+A P + SAS D + ++ +++ ++
Sbjct: 169 SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK 228
Query: 394 NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIV 444
H+ W V + DG +A+ + D ++RV ++ EH H+V
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
Score = 44.8 bits (101), Expect = 7e-04
Identities = 27/101 (26%), Positives = 48/101 (47%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV 77
G ++SGS I ++ V +G L + V + GK+I S A D + ++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ + TL H + SL F + ++TGS D +K+++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>EF011613-1|ABK41103.1| 513|Homo sapiens CDW3/SMU1 protein.
Length = 513
Score = 98.3 bits (234), Expect = 5e-20
Identities = 72/297 (24%), Positives = 133/297 (44%), Gaps = 16/297 (5%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGK--------FTLSVAYSPDGKYIAS 65
FSPDG+++++GS G I ++ +GK + L + + L + +S D + +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 66 GALDGIINIFDVAQGKLVHTLE-GHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
GA DG I ++ + G+ + E H+ + L FS DS +L+ S D ++++ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
GH+S+V F+ DG +S S+D TV++W++ + +C +TFK G
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTA-GTDITV 400
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
N +I + K P ++ V N V + + + + + + V A+SP G
Sbjct: 401 --NSVILL--PKNP--EHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRG 454
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
E I G+ R + D+ I P + +AT G + ++
Sbjct: 455 EWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 74.1 bits (174), Expect = 1e-12
Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 18/312 (5%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA--------SWV 135
H G + FSPD Q L+TGS DG +++++ + L A V
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF-KEHNDQVWGVKFNAESNKIISVSE 194
L + FS D + +G+ D ++VW + S QC F + H+ V + F+ +S++I+S S
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 195 DKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXX 254
D+ + +G L + + + E T +GH + ++ S DG
Sbjct: 328 DQTIRIHGLKSG--KTLKEFRGHSSFVNEATFTQDGHYI----ISASSDGTVKIWNMKTT 381
Query: 255 XXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKV-TVYGIINGTVDKVLD 313
G T +S + + +P+ V +T + + G I +
Sbjct: 382 ECSNTFKSLGSTAGTDITVNS-VILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKR 440
Query: 314 TRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G F+ A SP G +I E +Y F GK+ T+ H + V +A P L+
Sbjct: 441 EGGDFV-CCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLI 499
Query: 374 ASASNDGYVNVY 385
A+ S DG + ++
Sbjct: 500 ATYSEDGLLKLW 511
Score = 73.7 bits (173), Expect = 1e-12
Identities = 42/155 (27%), Positives = 81/155 (52%), Gaps = 10/155 (6%)
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ--------AVRSLAFSPKTKLLAS 375
+SPDG+Y+ +G+ G + +++ + GK+ ++ AQ AV + FS T++LA+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 376 ASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ DG + V+ I+S + + H + FS D ++ +++ D +IR+ L+ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
L F H+ V F DG ++S S D ++ I+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
Score = 70.9 bits (166), Expect = 9e-12
Identities = 43/167 (25%), Positives = 85/167 (50%), Gaps = 10/167 (5%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKFIMS------VAWSPDGRYIAS 333
FSPDG + TG G + V+ G + K L + F+M + +S D +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 334 GAEGGSVYLFDVSQGKMLHTIE-AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-A 391
GA+ G + ++ + G+ L E AH++ V L+FS + + SAS D + ++ ++S
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 392 LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ H + F+ DG + ++++DG++++ ++ +TF+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFK 388
Score = 58.8 bits (136), Expect = 4e-08
Identities = 36/124 (29%), Positives = 66/124 (53%), Gaps = 13/124 (10%)
Query: 355 EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCW---------AVSV 405
++H + R FSP + L + S DG++ V+N + ++ L ++ + +
Sbjct: 214 KSHVECAR---FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 270
Query: 406 CFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE-HTHIVCGVQFNADGSKLVSVSKDKS 464
CFS D + +AT A DG I+V ++ + L FE H+ V + F+ D S+++S S D++
Sbjct: 271 CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQT 330
Query: 465 INIY 468
I I+
Sbjct: 331 IRIH 334
Score = 56.0 bits (129), Expect = 3e-07
Identities = 39/178 (21%), Positives = 75/178 (42%), Gaps = 9/178 (5%)
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV---- 281
H G + V SPDG+ + G+ ++++ + D + ++
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 282 ----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLD-TRGKFIMSVAWSPDGRYIASGAE 336
FS D +ATG GK+ V+ I +G + + K + +++S D I S +
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQN 394
++ + + GK L H+ V F+ + SAS+DG V ++N+++ N
Sbjct: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385
Score = 48.0 bits (109), Expect = 7e-05
Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 11/197 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V L FS D ++S S I I G++SGK + F ++ DG YI S +
Sbjct: 310 VTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASS 369
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHM---KLYDVVHANLA 125
DG + I+++ + +T + S + +S +LL + + + + VV N+
Sbjct: 370 DGTVKIWNMKTTECSNTFKSLG-STAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ 428
Query: 126 GTL-----SG--HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVW 178
G + SG + A SP G+ D + + + + + T H V
Sbjct: 429 GQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI 488
Query: 179 GVKFNAESNKIISVSED 195
G+ + N I + SED
Sbjct: 489 GIAHHPHQNLIATYSED 505
>BC064638-1|AAH64638.1| 410|Homo sapiens platelet-activating factor
acetylhydrolase, isoform Ib, alpha subunit 45kDa
protein.
Length = 410
Score = 98.3 bits (234), Expect = 5e-20
Identities = 64/240 (26%), Positives = 110/240 (45%), Gaps = 8/240 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P ++S S I ++ E+G E+ L +++ GK +AS + D I
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++D + + T+ GH ++ S+ P+ +++ S D +K+++V T +GH
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV----WGVKFNAESNKI 189
WV V + DG S S D+TVRVW + + +C+ +EH V W + + S
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 190 ISVSEDK--GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ SE K G ++++G D +K+W L TL GH+ V V G+ I
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM--CLMTLVGHDNWVRGVLFHSGGKFI 353
Score = 93.1 bits (221), Expect = 2e-18
Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 39/343 (11%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPD 143
+ L GH + + F P ++++ S+D +K++D + TL GH V ++F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 144 GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYI 203
GK S SAD T+++WD +C T H+ V V P+ D+I
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIM--------------PNGDHI 207
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXX 263
V+ D +K+W + + T GH V V + DG IA
Sbjct: 208 VSASRDKTIKMWEVQTG--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT 265
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
+ E++ + I ++P+ S + TG T GK
Sbjct: 266 KECKAELREHEHVVECISWAPESSYSSISEATGSET-------------KKSGK------ 306
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++ SG+ ++ ++DVS G L T+ H VR + F K + S ++D +
Sbjct: 307 ---PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 384 VYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRV 425
V++ ++ L+ H+ + S+ F + T + D +++V
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 85.0 bits (201), Expect = 5e-16
Identities = 46/143 (32%), Positives = 72/143 (50%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V + P + S + D I ++D G TL+GH S++ + F +LL + S D
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL+D T+ GH V SVA P+G VS S D+T+++W++ + C TF H
Sbjct: 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233
Query: 174 NDQVWGVKFNAESNKIISVSEDK 196
+ V V+ N + I S S D+
Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQ 256
Score = 79.8 bits (188), Expect = 2e-14
Identities = 61/228 (26%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
+V ++ P+G H++S S I ++ V++G + ++ V + DG IAS +
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------------------LLLT 107
D + ++ VA + L H + + ++P+S LL+
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 108 GSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
GS D +K++DV TL GH +WV V F GK +S + D+T+RVWD + +C
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVW 215
T H V + F+ + Y+VTG +D VKVW
Sbjct: 374 KTLNAHEHFVTSLDFHKTA--------------PYVVTGSVDQTVKVW 407
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/294 (19%), Positives = 118/294 (40%), Gaps = 23/294 (7%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P +V+ D +KVW YE E TL+GH V ++ G+ +A
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR + ++ + P+G + + + ++ + G K +
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK------ 371
++ V + DG IAS + +V ++ V+ + + H V ++++P++
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 372 --------------LLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMAT 416
L S S D + ++++ + L + H W V F G+ + +
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
A D ++RV + R + T H H V + F+ +V+ S D+++ ++EC
Sbjct: 356 CADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409
Score = 67.3 bits (157), Expect = 1e-10
Identities = 32/101 (31%), Positives = 57/101 (56%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
G ++ SG+ D I ++DV+ G + TL GH +R + F + +L+ +DD ++++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+ TL+ H +V S+ F V+GS D+TV+VW+
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 60.9 bits (141), Expect = 1e-08
Identities = 32/119 (26%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPD 410
+ + H V + F P ++ SAS D + V++ E+ + L H + F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G+ +A+ +AD +I++ + F + T H H V V +G +VS S+DK+I ++E
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Score = 60.9 bits (141), Expect = 1e-08
Identities = 35/171 (20%), Positives = 78/171 (45%), Gaps = 1/171 (0%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S + +++F P S + + + V+ G ++ L + +++ G+ +AS
Sbjct: 109 SPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASC 168
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQ 393
+ ++ L+D + + T+ H V S+A P + SAS D + ++ +++ ++
Sbjct: 169 SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK 228
Query: 394 NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIV 444
H+ W V + DG +A+ + D ++RV ++ EH H+V
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
Score = 44.8 bits (101), Expect = 7e-04
Identities = 27/101 (26%), Positives = 48/101 (47%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV 77
G ++SGS I ++ V +G L + V + GK+I S A D + ++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ + TL H + SL F + ++TGS D +K+++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>BC002876-1|AAH02876.1| 513|Homo sapiens smu-1 suppressor of mec-8
and unc-52 homolog (C. elegans) protein.
Length = 513
Score = 98.3 bits (234), Expect = 5e-20
Identities = 72/297 (24%), Positives = 133/297 (44%), Gaps = 16/297 (5%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGK--------FTLSVAYSPDGKYIAS 65
FSPDG+++++GS G I ++ +GK + L + + L + +S D + +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 66 GALDGIINIFDVAQGKLVHTLE-GHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
GA DG I ++ + G+ + E H+ + L FS DS +L+ S D ++++ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
GH+S+V F+ DG +S S+D TV++W++ + +C +TFK G
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTA-GTDITV 400
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
N +I + K P ++ V N V + + + + + + V A+SP G
Sbjct: 401 --NSVILL--PKNP--EHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRG 454
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
E I G+ R + D+ I P + +AT G + ++
Sbjct: 455 EWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 74.1 bits (174), Expect = 1e-12
Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 18/312 (5%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA--------SWV 135
H G + FSPD Q L+TGS DG +++++ + L A V
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF-KEHNDQVWGVKFNAESNKIISVSE 194
L + FS D + +G+ D ++VW + S QC F + H+ V + F+ +S++I+S S
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 195 DKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXX 254
D+ + +G L + + + E T +GH + ++ S DG
Sbjct: 328 DQTIRIHGLKSG--KTLKEFRGHSSFVNEATFTQDGHYI----ISASSDGTVKIWNMKTT 381
Query: 255 XXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKV-TVYGIINGTVDKVLD 313
G T +S + + +P+ V +T + + G I +
Sbjct: 382 ECSNTFKSLGSTAGTDITVNS-VILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKR 440
Query: 314 TRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G F+ A SP G +I E +Y F GK+ T+ H + V +A P L+
Sbjct: 441 EGGDFV-CCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLI 499
Query: 374 ASASNDGYVNVY 385
A+ S DG + ++
Sbjct: 500 ATYSEDGLLKLW 511
Score = 73.7 bits (173), Expect = 1e-12
Identities = 42/155 (27%), Positives = 81/155 (52%), Gaps = 10/155 (6%)
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ--------AVRSLAFSPKTKLLAS 375
+SPDG+Y+ +G+ G + +++ + GK+ ++ AQ AV + FS T++LA+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 376 ASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ DG + V+ I+S + + H + FS D ++ +++ D +IR+ L+ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
L F H+ V F DG ++S S D ++ I+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
Score = 70.9 bits (166), Expect = 9e-12
Identities = 43/167 (25%), Positives = 85/167 (50%), Gaps = 10/167 (5%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKFIMS------VAWSPDGRYIAS 333
FSPDG + TG G + V+ G + K L + F+M + +S D +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 334 GAEGGSVYLFDVSQGKMLHTIE-AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-A 391
GA+ G + ++ + G+ L E AH++ V L+FS + + SAS D + ++ ++S
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 392 LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ H + F+ DG + ++++DG++++ ++ +TF+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFK 388
Score = 58.8 bits (136), Expect = 4e-08
Identities = 36/124 (29%), Positives = 66/124 (53%), Gaps = 13/124 (10%)
Query: 355 EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCW---------AVSV 405
++H + R FSP + L + S DG++ V+N + ++ L ++ + +
Sbjct: 214 KSHVECAR---FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 270
Query: 406 CFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE-HTHIVCGVQFNADGSKLVSVSKDKS 464
CFS D + +AT A DG I+V ++ + L FE H+ V + F+ D S+++S S D++
Sbjct: 271 CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQT 330
Query: 465 INIY 468
I I+
Sbjct: 331 IRIH 334
Score = 56.0 bits (129), Expect = 3e-07
Identities = 39/178 (21%), Positives = 75/178 (42%), Gaps = 9/178 (5%)
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV---- 281
H G + V SPDG+ + G+ ++++ + D + ++
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 282 ----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLD-TRGKFIMSVAWSPDGRYIASGAE 336
FS D +ATG GK+ V+ I +G + + K + +++S D I S +
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQN 394
++ + + GK L H+ V F+ + SAS+DG V ++N+++ N
Sbjct: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385
Score = 48.0 bits (109), Expect = 7e-05
Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 11/197 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V L FS D ++S S I I G++SGK + F ++ DG YI S +
Sbjct: 310 VTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASS 369
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHM---KLYDVVHANLA 125
DG + I+++ + +T + S + +S +LL + + + + VV N+
Sbjct: 370 DGTVKIWNMKTTECSNTFKSLG-STAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ 428
Query: 126 GTL-----SG--HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVW 178
G + SG + A SP G+ D + + + + + T H V
Sbjct: 429 GQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI 488
Query: 179 GVKFNAESNKIISVSED 195
G+ + N I + SED
Sbjct: 489 GIAHHPHQNLIATYSED 505
>AL162590-6|CAI15554.1| 513|Homo sapiens smu-1 suppressor of mec-8
and unc-52 homolog (C. elegans) protein.
Length = 513
Score = 98.3 bits (234), Expect = 5e-20
Identities = 72/297 (24%), Positives = 133/297 (44%), Gaps = 16/297 (5%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGK--------FTLSVAYSPDGKYIAS 65
FSPDG+++++GS G I ++ +GK + L + + L + +S D + +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 66 GALDGIINIFDVAQGKLVHTLE-GHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
GA DG I ++ + G+ + E H+ + L FS DS +L+ S D ++++ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
GH+S+V F+ DG +S S+D TV++W++ + +C +TFK G
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTA-GTDITV 400
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
N +I + K P ++ V N V + + + + + + V A+SP G
Sbjct: 401 --NSVILL--PKNP--EHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRG 454
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY 301
E I G+ R + D+ I P + +AT G + ++
Sbjct: 455 EWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 74.1 bits (174), Expect = 1e-12
Identities = 75/312 (24%), Positives = 129/312 (41%), Gaps = 18/312 (5%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA--------SWV 135
H G + FSPD Q L+TGS DG +++++ + L A V
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF-KEHNDQVWGVKFNAESNKIISVSE 194
L + FS D + +G+ D ++VW + S QC F + H+ V + F+ +S++I+S S
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 195 DKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXX 254
D+ + +G L + + + E T +GH + ++ S DG
Sbjct: 328 DQTIRIHGLKSG--KTLKEFRGHSSFVNEATFTQDGHYI----ISASSDGTVKIWNMKTT 381
Query: 255 XXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKV-TVYGIINGTVDKVLD 313
G T +S + + +P+ V +T + + G I +
Sbjct: 382 ECSNTFKSLGSTAGTDITVNS-VILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKR 440
Query: 314 TRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G F+ A SP G +I E +Y F GK+ T+ H + V +A P L+
Sbjct: 441 EGGDFV-CCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLI 499
Query: 374 ASASNDGYVNVY 385
A+ S DG + ++
Sbjct: 500 ATYSEDGLLKLW 511
Score = 73.7 bits (173), Expect = 1e-12
Identities = 42/155 (27%), Positives = 81/155 (52%), Gaps = 10/155 (6%)
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ--------AVRSLAFSPKTKLLAS 375
+SPDG+Y+ +G+ G + +++ + GK+ ++ AQ AV + FS T++LA+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 376 ASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ DG + V+ I+S + + H + FS D ++ +++ D +IR+ L+ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
L F H+ V F DG ++S S D ++ I+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
Score = 70.9 bits (166), Expect = 9e-12
Identities = 43/167 (25%), Positives = 85/167 (50%), Gaps = 10/167 (5%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKFIMS------VAWSPDGRYIAS 333
FSPDG + TG G + V+ G + K L + F+M + +S D +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 334 GAEGGSVYLFDVSQGKMLHTIE-AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-A 391
GA+ G + ++ + G+ L E AH++ V L+FS + + SAS D + ++ ++S
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 392 LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ H + F+ DG + ++++DG++++ ++ +TF+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFK 388
Score = 58.8 bits (136), Expect = 4e-08
Identities = 36/124 (29%), Positives = 66/124 (53%), Gaps = 13/124 (10%)
Query: 355 EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCW---------AVSV 405
++H + R FSP + L + S DG++ V+N + ++ L ++ + +
Sbjct: 214 KSHVECAR---FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 270
Query: 406 CFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE-HTHIVCGVQFNADGSKLVSVSKDKS 464
CFS D + +AT A DG I+V ++ + L FE H+ V + F+ D S+++S S D++
Sbjct: 271 CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQT 330
Query: 465 INIY 468
I I+
Sbjct: 331 IRIH 334
Score = 56.0 bits (129), Expect = 3e-07
Identities = 39/178 (21%), Positives = 75/178 (42%), Gaps = 9/178 (5%)
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV---- 281
H G + V SPDG+ + G+ ++++ + D + ++
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 282 ----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLD-TRGKFIMSVAWSPDGRYIASGAE 336
FS D +ATG GK+ V+ I +G + + K + +++S D I S +
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQN 394
++ + + GK L H+ V F+ + SAS+DG V ++N+++ N
Sbjct: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385
Score = 48.0 bits (109), Expect = 7e-05
Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 11/197 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V L FS D ++S S I I G++SGK + F ++ DG YI S +
Sbjct: 310 VTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASS 369
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHM---KLYDVVHANLA 125
DG + I+++ + +T + S + +S +LL + + + + VV N+
Sbjct: 370 DGTVKIWNMKTTECSNTFKSLG-STAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ 428
Query: 126 GTL-----SG--HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVW 178
G + SG + A SP G+ D + + + + + T H V
Sbjct: 429 GQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI 488
Query: 179 GVKFNAESNKIISVSED 195
G+ + N I + SED
Sbjct: 489 GIAHHPHQNLIATYSED 505
>AL121990-7|CAI22015.1| 589|Homo sapiens TAF5-like RNA polymerase
II, p300/CBP-associated factor (PCAF)-associated facto
protein.
Length = 589
Score = 98.3 bits (234), Expect = 5e-20
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 1/184 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
VW LD SP + SGS+ ++ + ++ V + P+ Y+A+G+
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ QG V GH + SL FSP+ + L + +D +KL+D+ L L
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
GH + S+ FSPD S S D +VRVWD+ + C + ++ GV + + +
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGV-YTGQMSN 565
Query: 189 IISV 192
++SV
Sbjct: 566 VLSV 569
Score = 92.3 bits (219), Expect = 3e-18
Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 16/226 (7%)
Query: 80 GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVA 139
G + L GH + S F DS LL+ S+D ++ +D+ GHA V +
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 391
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
SP F SGS DRT R+W D + H V VKF+ P+
Sbjct: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH--------------PN 437
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+Y+ TG D V++WS + L T GH PV+S+A SP+G+ +A
Sbjct: 438 SNYLATGSTDKTVRLWSAQQGNSVRLFT--GHRGPVLSLAFSPNGKYLASAGEDQRLKLW 495
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIIN 305
G +E++ + ++ + FSPD +A+ V V+ I N
Sbjct: 496 DLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 82.2 bits (194), Expect = 4e-15
Identities = 44/139 (31%), Positives = 67/139 (48%)
Query: 57 SPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
SP Y ASG+ D ++ + + GH + + F P+S L TGS D ++L
Sbjct: 393 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452
Query: 117 YDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQ 176
+ N +GH VLS+AFSP+GK S D+ +++WDL S + H D
Sbjct: 453 WSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN 512
Query: 177 VWGVKFNAESNKIISVSED 195
+ + F+ +S I S S D
Sbjct: 513 ITSLTFSPDSGLIASASMD 531
Score = 81.4 bits (192), Expect = 6e-15
Identities = 41/133 (30%), Positives = 73/133 (54%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L DV + F P+ ++ +GS + ++ + G ++ LS+A+SP+GKY+AS
Sbjct: 426 LADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLAS 485
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D + ++D+A G L L GH +I SL FSPDS L+ + S D ++++D+ + +
Sbjct: 486 AGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCS 545
Query: 126 GTLSGHASWVLSV 138
G +S ++ V
Sbjct: 546 APADGSSSELVGV 558
Score = 81.0 bits (191), Expect = 8e-15
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 26/289 (8%)
Query: 57 SPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
SPD K +A+G + I ++ + KL E H + + + + D +L DD
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKKL--KSEPHQVDVSRIHLACD---ILEEEDD----- 326
Query: 117 YDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQ 176
D L GH V S F D +S S D ++R WDL S ++ H
Sbjct: 327 EDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYP 386
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVV 236
VW + D P Y +G D ++WS++ + L GH V
Sbjct: 387 VWDL--------------DISPYSLYFASGSHDRTARLWSFD--RTYPLRIYAGHLADVD 430
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
V P+ +A G +R + + FSP+G +A+ G
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV 345
++ ++ + +GT+ K L I S+ +SPD IAS + SV ++D+
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 78.2 bits (184), Expect = 6e-14
Identities = 70/291 (24%), Positives = 125/291 (42%), Gaps = 26/291 (8%)
Query: 99 SPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRV 158
SPDS+LL G D+ +KL+ + L H V + + D + D
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKKLKS--EPHQVDVSRIHLACD---ILEEEDDE---- 327
Query: 159 WDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE 218
D ++ + H V+ +F A+S+ ++S SED ++ W
Sbjct: 328 -DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMS--------------IRYWDLG 372
Query: 219 NNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
+ +L+ +GH PV + +SP A +R +D+
Sbjct: 373 SFTNTVLY--QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD 430
Query: 279 KIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGG 338
+ F P+ + +ATG V ++ G ++ ++S+A+SP+G+Y+AS E
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490
Query: 339 SVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES 389
+ L+D++ G + + H + SL FSP + L+ASAS D V V++I +
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 70.9 bits (166), Expect = 9e-12
Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 1/150 (0%)
Query: 277 MWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAE 336
+W + SP A+G H ++ ++ + V + P+ Y+A+G+
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
+V L+ QG + H V SLAFSP K LASA D + ++++ S L +L
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Query: 397 -DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
H S+ FSPD +A+++ D S+RV
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRV 536
Score = 63.3 bits (147), Expect = 2e-09
Identities = 50/196 (25%), Positives = 76/196 (38%), Gaps = 16/196 (8%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
S + D + S + D I +D+ +GHA + L SP S +GS D
Sbjct: 347 STRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDR 406
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+L+ +GH + V V F P+ +GS D+TVR+W F
Sbjct: 407 TARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTG 466
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H V + F+ P+ Y+ + G D +K+W + L L GH
Sbjct: 467 HRGPVLSLAFS--------------PNGKYLASAGEDQRLKLWDLASG--TLYKELRGHT 510
Query: 233 MPVVSVAVSPDGETIA 248
+ S+ SPD IA
Sbjct: 511 DNITSLTFSPDSGLIA 526
Score = 60.5 bits (140), Expect = 1e-08
Identities = 54/286 (18%), Positives = 121/286 (42%), Gaps = 16/286 (5%)
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDN-LVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
+ ++++ +E SK ++ G DN +K+WS + KL+ E H++ V + ++ D
Sbjct: 267 TEQLLNTAEISPDSK--LLAAGFDNSCIKLWSLRSKKLKS----EPHQVDVSRIHLACD- 319
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
G +++ ++ ++ F D S + + + + +
Sbjct: 320 -------ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLG 372
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSL 364
+ T + + + SP Y ASG+ + L+ + L H V +
Sbjct: 373 SFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCV 432
Query: 365 AFSPKTKLLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSI 423
F P + LA+ S D V +++ + +++ H+ +S+ FSP+G+ +A++ D +
Sbjct: 433 KFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRL 492
Query: 424 RVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ L + HT + + F+ D + S S D S+ +++
Sbjct: 493 KLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
>AJ009770-1|CAA08816.1| 260|Homo sapiens putative transcription
factor protein.
Length = 260
Score = 98.3 bits (234), Expect = 5e-20
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 1/184 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
VW LD SP + SGS+ ++ + ++ V + P+ Y+A+G+
Sbjct: 58 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 117
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ QG V GH + SL FSP+ + L + +D +KL+D+ L L
Sbjct: 118 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 177
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
GH + S+ FSPD S S D +VRVWD+ + C + ++ GV + + +
Sbjct: 178 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGV-YTGQMSN 236
Query: 189 IISV 192
++SV
Sbjct: 237 VLSV 240
Score = 92.3 bits (219), Expect = 3e-18
Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 16/226 (7%)
Query: 80 GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVA 139
G + L GH + S F DS LL+ S+D ++ +D+ GHA V +
Sbjct: 3 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 62
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
SP F SGS DRT R+W D + H V VKF+ P+
Sbjct: 63 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH--------------PN 108
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+Y+ TG D V++WS + L T GH PV+S+A SP+G+ +A
Sbjct: 109 SNYLATGSTDKTVRLWSAQQGNSVRLFT--GHRGPVLSLAFSPNGKYLASAGEDQRLKLW 166
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIIN 305
G +E++ + ++ + FSPD +A+ V V+ I N
Sbjct: 167 DLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 212
Score = 82.2 bits (194), Expect = 4e-15
Identities = 44/139 (31%), Positives = 67/139 (48%)
Query: 57 SPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
SP Y ASG+ D ++ + + GH + + F P+S L TGS D ++L
Sbjct: 64 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 123
Query: 117 YDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQ 176
+ N +GH VLS+AFSP+GK S D+ +++WDL S + H D
Sbjct: 124 WSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN 183
Query: 177 VWGVKFNAESNKIISVSED 195
+ + F+ +S I S S D
Sbjct: 184 ITSLTFSPDSGLIASASMD 202
Score = 81.4 bits (192), Expect = 6e-15
Identities = 41/133 (30%), Positives = 73/133 (54%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L DV + F P+ ++ +GS + ++ + G ++ LS+A+SP+GKY+AS
Sbjct: 97 LADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLAS 156
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D + ++D+A G L L GH +I SL FSPDS L+ + S D ++++D+ + +
Sbjct: 157 AGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCS 216
Query: 126 GTLSGHASWVLSV 138
G +S ++ V
Sbjct: 217 APADGSSSELVGV 229
Score = 77.0 bits (181), Expect = 1e-13
Identities = 54/217 (24%), Positives = 98/217 (45%), Gaps = 16/217 (7%)
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H V+ +F A+S+ ++S SED ++ W + +L+ +GH
Sbjct: 12 HCGPVYSTRFLADSSGLLSCSEDMS--------------IRYWDLGSFTNTVLY--QGHA 55
Query: 233 MPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATG 292
PV + +SP A +R +D+ + F P+ + +ATG
Sbjct: 56 YPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATG 115
Query: 293 GHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLH 352
V ++ G ++ ++S+A+SP+G+Y+AS E + L+D++ G +
Sbjct: 116 STDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYK 175
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES 389
+ H + SL FSP + L+ASAS D V V++I +
Sbjct: 176 ELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 212
Score = 70.9 bits (166), Expect = 9e-12
Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 1/150 (0%)
Query: 277 MWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAE 336
+W + SP A+G H ++ ++ + V + P+ Y+A+G+
Sbjct: 58 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 117
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
+V L+ QG + H V SLAFSP K LASA D + ++++ S L +L
Sbjct: 118 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 177
Query: 397 -DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
H S+ FSPD +A+++ D S+RV
Sbjct: 178 RGHTDNITSLTFSPDSGLIASASMDNSVRV 207
Score = 63.3 bits (147), Expect = 2e-09
Identities = 50/196 (25%), Positives = 76/196 (38%), Gaps = 16/196 (8%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
S + D + S + D I +D+ +GHA + L SP S +GS D
Sbjct: 18 STRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDR 77
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+L+ +GH + V V F P+ +GS D+TVR+W F
Sbjct: 78 TARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTG 137
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H V + F+ P+ Y+ + G D +K+W + L L GH
Sbjct: 138 HRGPVLSLAFS--------------PNGKYLASAGEDQRLKLWDLASG--TLYKELRGHT 181
Query: 233 MPVVSVAVSPDGETIA 248
+ S+ SPD IA
Sbjct: 182 DNITSLTFSPDSGLIA 197
Score = 58.0 bits (134), Expect = 7e-08
Identities = 34/146 (23%), Positives = 68/146 (46%), Gaps = 1/146 (0%)
Query: 325 SPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNV 384
SP Y ASG+ + L+ + L H V + F P + LA+ S D V +
Sbjct: 64 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 123
Query: 385 YNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
++ + +++ H+ +S+ FSP+G+ +A++ D +++ L + HT
Sbjct: 124 WSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN 183
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F+ D + S S D S+ +++
Sbjct: 184 ITSLTFSPDSGLIASASMDNSVRVWD 209
Score = 49.6 bits (113), Expect = 2e-05
Identities = 37/165 (22%), Positives = 72/165 (43%), Gaps = 1/165 (0%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA 365
GT K+L + S + D + S +E S+ +D+ + HA V L
Sbjct: 3 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 62
Query: 366 FSPKTKLLASASNDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIR 424
SP + AS S+D +++ + + L+ H V F P+ +AT + D ++R
Sbjct: 63 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVR 122
Query: 425 VVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ ++ + F H V + F+ +G L S +D+ + +++
Sbjct: 123 LWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 167
>AF400434-1|AAK92483.1| 410|Homo sapiens platelet-activating factor
acetyl hydrolase isoform Ib alpha subunit protein.
Length = 410
Score = 98.3 bits (234), Expect = 5e-20
Identities = 64/240 (26%), Positives = 110/240 (45%), Gaps = 8/240 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P ++S S I ++ E+G E+ L +++ GK +AS + D I
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++D + + T+ GH ++ S+ P+ +++ S D +K+++V T +GH
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV----WGVKFNAESNKI 189
WV V + DG S S D+TVRVW + + +C+ +EH V W + + S
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 190 ISVSEDK--GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ SE K G ++++G D +K+W L TL GH+ V V G+ I
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM--CLMTLVGHDNWVRGVLFHSGGKFI 353
Score = 93.1 bits (221), Expect = 2e-18
Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 39/343 (11%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPD 143
+ L GH + + F P ++++ S+D +K++D + TL GH V ++F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 144 GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYI 203
GK S SAD T+++WD +C T H+ V V P+ D+I
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIM--------------PNGDHI 207
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXX 263
V+ D +K+W + + T GH V V + DG IA
Sbjct: 208 VSASRDKTIKMWEVQTG--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT 265
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
+ E++ + I ++P+ S + TG T GK
Sbjct: 266 KECKAELREHEHVVECISWAPESSYSSISEATGSET-------------KKSGK------ 306
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++ SG+ ++ ++DVS G L T+ H VR + F K + S ++D +
Sbjct: 307 ---PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 384 VYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRV 425
V++ ++ L+ H+ + S+ F + T + D +++V
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 85.0 bits (201), Expect = 5e-16
Identities = 46/143 (32%), Positives = 72/143 (50%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V + P + S + D I ++D G TL+GH S++ + F +LL + S D
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL+D T+ GH V SVA P+G VS S D+T+++W++ + C TF H
Sbjct: 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233
Query: 174 NDQVWGVKFNAESNKIISVSEDK 196
+ V V+ N + I S S D+
Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQ 256
Score = 79.8 bits (188), Expect = 2e-14
Identities = 61/228 (26%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
+V ++ P+G H++S S I ++ V++G + ++ V + DG IAS +
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------------------LLLT 107
D + ++ VA + L H + + ++P+S LL+
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 108 GSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
GS D +K++DV TL GH +WV V F GK +S + D+T+RVWD + +C
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVW 215
T H V + F+ + Y+VTG +D VKVW
Sbjct: 374 KTLNAHEHFVTSLDFHKTA--------------PYVVTGSVDQTVKVW 407
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/294 (19%), Positives = 118/294 (40%), Gaps = 23/294 (7%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P +V+ D +KVW YE E TL+GH V ++ G+ +A
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR + ++ + P+G + + + ++ + G K +
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK------ 371
++ V + DG IAS + +V ++ V+ + + H V ++++P++
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 372 --------------LLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMAT 416
L S S D + ++++ + L + H W V F G+ + +
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
A D ++RV + R + T H H V + F+ +V+ S D+++ ++EC
Sbjct: 356 CADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409
Score = 67.3 bits (157), Expect = 1e-10
Identities = 32/101 (31%), Positives = 57/101 (56%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
G ++ SG+ D I ++DV+ G + TL GH +R + F + +L+ +DD ++++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+ TL+ H +V S+ F V+GS D+TV+VW+
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 60.9 bits (141), Expect = 1e-08
Identities = 32/119 (26%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPD 410
+ + H V + F P ++ SAS D + V++ E+ + L H + F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G+ +A+ +AD +I++ + F + T H H V V +G +VS S+DK+I ++E
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Score = 60.9 bits (141), Expect = 1e-08
Identities = 35/171 (20%), Positives = 78/171 (45%), Gaps = 1/171 (0%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S + +++F P S + + + V+ G ++ L + +++ G+ +AS
Sbjct: 109 SPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASC 168
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQ 393
+ ++ L+D + + T+ H V S+A P + SAS D + ++ +++ ++
Sbjct: 169 SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK 228
Query: 394 NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIV 444
H+ W V + DG +A+ + D ++RV ++ EH H+V
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
Score = 44.8 bits (101), Expect = 7e-04
Identities = 27/101 (26%), Positives = 48/101 (47%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV 77
G ++SGS I ++ V +G L + V + GK+I S A D + ++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ + TL H + SL F + ++TGS D +K+++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>AF208837-1|AAL34972.1| 410|Homo sapiens Miller-Dieker
lissencephaly protein protein.
Length = 410
Score = 98.3 bits (234), Expect = 5e-20
Identities = 64/240 (26%), Positives = 110/240 (45%), Gaps = 8/240 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P ++S S I ++ E+G E+ L +++ GK +AS + D I
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++D + + T+ GH ++ S+ P+ +++ S D +K+++V T +GH
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV----WGVKFNAESNKI 189
WV V + DG S S D+TVRVW + + +C+ +EH V W + + S
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 190 ISVSEDK--GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ SE K G ++++G D +K+W L TL GH+ V V G+ I
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM--CLMTLVGHDNWVRGVLFHSGGKFI 353
Score = 93.1 bits (221), Expect = 2e-18
Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 39/343 (11%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPD 143
+ L GH + + F P ++++ S+D +K++D + TL GH V ++F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 144 GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYI 203
GK S SAD T+++WD +C T H+ V V P+ D+I
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIM--------------PNGDHI 207
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXX 263
V+ D +K+W + + T GH V V + DG IA
Sbjct: 208 VSASRDKTIKMWEVQTG--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT 265
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
+ E++ + I ++P+ S + TG T GK
Sbjct: 266 KECKAELREHEHVVECISWAPESSYSSISEATGSET-------------KKSGK------ 306
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++ SG+ ++ ++DVS G L T+ H VR + F K + S ++D +
Sbjct: 307 ---PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 384 VYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRV 425
V++ ++ L+ H+ + S+ F + T + D +++V
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 85.0 bits (201), Expect = 5e-16
Identities = 46/143 (32%), Positives = 72/143 (50%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V + P + S + D I ++D G TL+GH S++ + F +LL + S D
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL+D T+ GH V SVA P+G VS S D+T+++W++ + C TF H
Sbjct: 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233
Query: 174 NDQVWGVKFNAESNKIISVSEDK 196
+ V V+ N + I S S D+
Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQ 256
Score = 79.8 bits (188), Expect = 2e-14
Identities = 61/228 (26%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
+V ++ P+G H++S S I ++ V++G + ++ V + DG IAS +
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------------------LLLT 107
D + ++ VA + L H + + ++P+S LL+
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 108 GSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
GS D +K++DV TL GH +WV V F GK +S + D+T+RVWD + +C
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVW 215
T H V + F+ + Y+VTG +D VKVW
Sbjct: 374 KTLNAHEHFVTSLDFHKTA--------------PYVVTGSVDQTVKVW 407
Score = 75.4 bits (177), Expect = 4e-13
Identities = 58/294 (19%), Positives = 118/294 (40%), Gaps = 23/294 (7%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P +V+ D +KVW YE E TL+GH V ++ G+ +A
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR + ++ + P+G + + + ++ + G K +
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK------ 371
++ V + DG IAS + +V ++ V+ + + H V ++++P++
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 372 --------------LLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMAT 416
L S S D + ++++ + L + H W V F G+ + +
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
A D ++RV + R + T H H V + F+ +V+ S D+++ ++EC
Sbjct: 356 CADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409
Score = 67.3 bits (157), Expect = 1e-10
Identities = 32/101 (31%), Positives = 57/101 (56%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
G ++ SG+ D I ++DV+ G + TL GH +R + F + +L+ +DD ++++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+ TL+ H +V S+ F V+GS D+TV+VW+
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 60.9 bits (141), Expect = 1e-08
Identities = 32/119 (26%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPD 410
+ + H V + F P ++ SAS D + V++ E+ + L H + F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G+ +A+ +AD +I++ + F + T H H V V +G +VS S+DK+I ++E
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Score = 60.9 bits (141), Expect = 1e-08
Identities = 35/171 (20%), Positives = 78/171 (45%), Gaps = 1/171 (0%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S + +++F P S + + + V+ G ++ L + +++ G+ +AS
Sbjct: 109 SPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASC 168
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQ 393
+ ++ L+D + + T+ H V S+A P + SAS D + ++ +++ ++
Sbjct: 169 SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK 228
Query: 394 NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIV 444
H+ W V + DG +A+ + D ++RV ++ EH H+V
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
Score = 44.8 bits (101), Expect = 7e-04
Identities = 27/101 (26%), Positives = 48/101 (47%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV 77
G ++SGS I ++ V +G L + V + GK+I S A D + ++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ + TL H + SL F + ++TGS D +K+++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>AF069736-1|AAC39906.1| 589|Homo sapiens PCAF associated factor 65
beta protein.
Length = 589
Score = 98.3 bits (234), Expect = 5e-20
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 1/184 (0%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
VW LD SP + SGS+ ++ + ++ V + P+ Y+A+G+
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D + ++ QG V GH + SL FSP+ + L + +D +KL+D+ L L
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
GH + S+ FSPD S S D +VRVWD+ + C + ++ GV + + +
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGV-YTGQMSN 565
Query: 189 IISV 192
++SV
Sbjct: 566 VLSV 569
Score = 92.3 bits (219), Expect = 3e-18
Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 16/226 (7%)
Query: 80 GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVA 139
G + L GH + S F DS LL+ S+D ++ +D+ GHA V +
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 391
Query: 140 FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPS 199
SP F SGS DRT R+W D + H V VKF+ P+
Sbjct: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH--------------PN 437
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
+Y+ TG D V++WS + L T GH PV+S+A SP+G+ +A
Sbjct: 438 SNYLATGSTDKTVRLWSAQQGNSVRLFT--GHRGPVLSLAFSPNGKYLASAGEDQRLKLW 495
Query: 260 XXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIIN 305
G +E++ + ++ + FSPD +A+ V V+ I N
Sbjct: 496 DLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 82.2 bits (194), Expect = 4e-15
Identities = 44/139 (31%), Positives = 67/139 (48%)
Query: 57 SPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
SP Y ASG+ D ++ + + GH + + F P+S L TGS D ++L
Sbjct: 393 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452
Query: 117 YDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQ 176
+ N +GH VLS+AFSP+GK S D+ +++WDL S + H D
Sbjct: 453 WSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN 512
Query: 177 VWGVKFNAESNKIISVSED 195
+ + F+ +S I S S D
Sbjct: 513 ITSLTFSPDSGLIASASMD 531
Score = 81.4 bits (192), Expect = 6e-15
Identities = 41/133 (30%), Positives = 73/133 (54%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L DV + F P+ ++ +GS + ++ + G ++ LS+A+SP+GKY+AS
Sbjct: 426 LADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLAS 485
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D + ++D+A G L L GH +I SL FSPDS L+ + S D ++++D+ + +
Sbjct: 486 AGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCS 545
Query: 126 GTLSGHASWVLSV 138
G +S ++ V
Sbjct: 546 APADGSSSELVGV 558
Score = 81.0 bits (191), Expect = 8e-15
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 26/289 (8%)
Query: 57 SPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
SPD K +A+G + I ++ + KL E H + + + + D +L DD
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKKL--KSEPHQVDVSRIHLACD---ILEEEDD----- 326
Query: 117 YDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQ 176
D L GH V S F D +S S D ++R WDL S ++ H
Sbjct: 327 EDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYP 386
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVV 236
VW + D P Y +G D ++WS++ + L GH V
Sbjct: 387 VWDL--------------DISPYSLYFASGSHDRTARLWSFD--RTYPLRIYAGHLADVD 430
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
V P+ +A G +R + + FSP+G +A+ G
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV 345
++ ++ + +GT+ K L I S+ +SPD IAS + SV ++D+
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 78.2 bits (184), Expect = 6e-14
Identities = 70/291 (24%), Positives = 125/291 (42%), Gaps = 26/291 (8%)
Query: 99 SPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRV 158
SPDS+LL G D+ +KL+ + L H V + + D + D
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKKLKS--EPHQVDVSRIHLACD---ILEEEDDE---- 327
Query: 159 WDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE 218
D ++ + H V+ +F A+S+ ++S SED ++ W
Sbjct: 328 -DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMS--------------IRYWDLG 372
Query: 219 NNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
+ +L+ +GH PV + +SP A +R +D+
Sbjct: 373 SFTNTVLY--QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD 430
Query: 279 KIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGG 338
+ F P+ + +ATG V ++ G ++ ++S+A+SP+G+Y+AS E
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490
Query: 339 SVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES 389
+ L+D++ G + + H + SL FSP + L+ASAS D V V++I +
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 70.9 bits (166), Expect = 9e-12
Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 1/150 (0%)
Query: 277 MWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAE 336
+W + SP A+G H ++ ++ + V + P+ Y+A+G+
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL 396
+V L+ QG + H V SLAFSP K LASA D + ++++ S L +L
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Query: 397 -DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
H S+ FSPD +A+++ D S+RV
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRV 536
Score = 63.3 bits (147), Expect = 2e-09
Identities = 50/196 (25%), Positives = 76/196 (38%), Gaps = 16/196 (8%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
S + D + S + D I +D+ +GHA + L SP S +GS D
Sbjct: 347 STRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDR 406
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+L+ +GH + V V F P+ +GS D+TVR+W F
Sbjct: 407 TARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTG 466
Query: 173 HNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
H V + F+ P+ Y+ + G D +K+W + L L GH
Sbjct: 467 HRGPVLSLAFS--------------PNGKYLASAGEDQRLKLWDLASG--TLYKELRGHT 510
Query: 233 MPVVSVAVSPDGETIA 248
+ S+ SPD IA
Sbjct: 511 DNITSLTFSPDSGLIA 526
Score = 60.5 bits (140), Expect = 1e-08
Identities = 54/286 (18%), Positives = 121/286 (42%), Gaps = 16/286 (5%)
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDN-LVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
+ ++++ +E SK ++ G DN +K+WS + KL+ E H++ V + ++ D
Sbjct: 267 TEQLLNTAEISPDSK--LLAAGFDNSCIKLWSLRSKKLKS----EPHQVDVSRIHLACD- 319
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
G +++ ++ ++ F D S + + + + +
Sbjct: 320 -------ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLG 372
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSL 364
+ T + + + SP Y ASG+ + L+ + L H V +
Sbjct: 373 SFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCV 432
Query: 365 AFSPKTKLLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSI 423
F P + LA+ S D V +++ + +++ H+ +S+ FSP+G+ +A++ D +
Sbjct: 433 KFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRL 492
Query: 424 RVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ L + HT + + F+ D + S S D S+ +++
Sbjct: 493 KLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
>BC015920-1|AAH15920.1| 297|Homo sapiens GNB3 protein protein.
Length = 297
Score = 97.5 bits (232), Expect = 9e-20
Identities = 62/247 (25%), Positives = 116/247 (46%), Gaps = 20/247 (8%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 115 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
F + S +++ D D VW ++ K E + L GH+ V + V+
Sbjct: 234 FFSLSGRLLFAGYD-------------DFNCNVW--DSMKSERVGILSGHDNRVSCLGVT 278
Query: 242 PDGETIA 248
DG +A
Sbjct: 279 ADGMAVA 285
Score = 82.6 bits (195), Expect = 3e-15
Identities = 43/145 (29%), Positives = 74/145 (51%), Gaps = 1/145 (0%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
V +G T GH I ++CF S +LL G DD + ++D + + G LSGH + V
Sbjct: 213 VREGTCRQTFTGHESDINAICFFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRV 272
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWD 160
+ + DG +GS D +++W+
Sbjct: 273 SCLGVTADGMAVATGSWDSFLKIWN 297
Score = 58.0 bits (134), Expect = 7e-08
Identities = 57/252 (22%), Positives = 102/252 (40%), Gaps = 14/252 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 110 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 265 QKIREIQTDSSDMWKI-VFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
+ SD+ I FS G + G V+ + +L + +
Sbjct: 217 TCRQTFTGHESDINAICFFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLG 276
Query: 324 WSPDGRYIASGA 335
+ DG +A+G+
Sbjct: 277 VTADGMAVATGS 288
Score = 50.8 bits (116), Expect = 1e-05
Identities = 50/248 (20%), Positives = 93/248 (37%), Gaps = 7/248 (2%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 402 AVSVC-FSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVS 460
++C FS G+ + D + V + + H + V + ADG + + S
Sbjct: 229 INAICFFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 288
Query: 461 KDKSINIY 468
D + I+
Sbjct: 289 WDSFLKIW 296
Score = 48.8 bits (111), Expect = 4e-05
Identities = 32/155 (20%), Positives = 69/155 (44%), Gaps = 4/155 (2%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
I ++ W+ D + + S ++ G + ++D +H I + V + A++P +A
Sbjct: 58 IYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGL 117
Query: 379 DGYVNVYNIESAALQNKLDHKCWA----VSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
D ++YN++S K+ + A +S C D + TS+ D + + +E +
Sbjct: 118 DNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQK 177
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
F HT + + D + +S + D S +++
Sbjct: 178 TVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Score = 48.0 bits (109), Expect = 7e-05
Identities = 56/232 (24%), Positives = 96/232 (41%), Gaps = 15/232 (6%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 70 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 126
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 127 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 185
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLA-FSPKTKLLASA 376
MS+A SPD SGA S L+DV +G T H + ++ FS +LL +
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFSLSGRLLFAG 245
Query: 377 SNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+D NV++ E + + D++ + V + DG +AT + D +++
Sbjct: 246 YDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSWDSFLKI 295
Score = 46.4 bits (105), Expect = 2e-04
Identities = 41/208 (19%), Positives = 88/208 (42%), Gaps = 7/208 (3%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 443 IVCGV-QFNADGSKLVSVSKDKSINIYE 469
+ + F+ G L + D + N+++
Sbjct: 228 DINAICFFSLSGRLLFAGYDDFNCNVWD 255
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BC110654-1|AAI10655.1| 513|Homo sapiens smu-1 suppressor of mec-8
and unc-52 homolog (C. elegans) protein.
Length = 513
Score = 97.1 bits (231), Expect = 1e-19
Identities = 71/287 (24%), Positives = 129/287 (44%), Gaps = 16/287 (5%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGK--------FTLSVAYSPDGKYIAS 65
FSPDG+++++GS G I ++ +GK + L + + L + +S D + +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 66 GALDGIINIFDVAQGKLVHTLE-GHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
GA DG I ++ + G+ + E H+ + L FS DS +L+ S D ++++ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
GH+S+V F+ DG +S S+D TV++W++ + +C +TFK G
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTA-GTDITV 400
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
N +I + K P ++ V N V + + + + + + V A+SP G
Sbjct: 401 --NSVILL--PKNP--EHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRG 454
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
E I G+ R + D+ I P + +AT
Sbjct: 455 EWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIAT 501
Score = 73.7 bits (173), Expect = 1e-12
Identities = 42/155 (27%), Positives = 81/155 (52%), Gaps = 10/155 (6%)
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ--------AVRSLAFSPKTKLLAS 375
+SPDG+Y+ +G+ G + +++ + GK+ ++ AQ AV + FS T++LA+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 376 ASNDGYVNVYNIESAALQNKLD--HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRV 433
+ DG + V+ I+S + + H + FS D ++ +++ D +IR+ L+ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 434 LHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
L F H+ V F DG ++S S D ++ I+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
Score = 71.7 bits (168), Expect = 5e-12
Identities = 74/312 (23%), Positives = 128/312 (41%), Gaps = 18/312 (5%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA--------SWV 135
H G + FSPD Q L+TGS DG +++++ + L A V
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF-KEHNDQVWGVKFNAESNKIISVSE 194
L + FS D + +G+ D ++VW + S QC F + H+ V + F+ +S++I+S S
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 195 DKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXX 254
D+ + +G L + + + E T +GH + ++ S DG
Sbjct: 328 DQTIRIHGLKSG--KTLKEFRGHSSFVNEATFTQDGHYI----ISASSDGTVKIWNMKTT 381
Query: 255 XXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKV-TVYGIINGTVDKVLD 313
G T +S + + +P+ V +T + + G I +
Sbjct: 382 ECSNTFKSLGSTAGTDITVNS-VILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKR 440
Query: 314 TRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
G F+ A SP G +I E +Y F GK+ T+ H + V +A P L+
Sbjct: 441 EGGDFV-CCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLI 499
Query: 374 ASASNDGYVNVY 385
A+ S D + ++
Sbjct: 500 ATYSEDALLKLW 511
Score = 70.9 bits (166), Expect = 9e-12
Identities = 43/167 (25%), Positives = 85/167 (50%), Gaps = 10/167 (5%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVL--DTRGKFIMS------VAWSPDGRYIAS 333
FSPDG + TG G + V+ G + K L + F+M + +S D +A+
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 334 GAEGGSVYLFDVSQGKMLHTIE-AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-A 391
GA+ G + ++ + G+ L E AH++ V L+FS + + SAS D + ++ ++S
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 392 LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE 438
L+ H + F+ DG + ++++DG++++ ++ +TF+
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFK 388
Score = 58.8 bits (136), Expect = 4e-08
Identities = 36/124 (29%), Positives = 66/124 (53%), Gaps = 13/124 (10%)
Query: 355 EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCW---------AVSV 405
++H + R FSP + L + S DG++ V+N + ++ L ++ + +
Sbjct: 214 KSHVECAR---FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 270
Query: 406 CFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE-HTHIVCGVQFNADGSKLVSVSKDKS 464
CFS D + +AT A DG I+V ++ + L FE H+ V + F+ D S+++S S D++
Sbjct: 271 CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQT 330
Query: 465 INIY 468
I I+
Sbjct: 331 IRIH 334
Score = 56.0 bits (129), Expect = 3e-07
Identities = 39/178 (21%), Positives = 75/178 (42%), Gaps = 9/178 (5%)
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIV---- 281
H G + V SPDG+ + G+ ++++ + D + ++
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 282 ----FSPDGSQVATGGHTGKVTVYGIINGTVDKVLD-TRGKFIMSVAWSPDGRYIASGAE 336
FS D +ATG GK+ V+ I +G + + K + +++S D I S +
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
Query: 337 GGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQN 394
++ + + GK L H+ V F+ + SAS+DG V ++N+++ N
Sbjct: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385
Score = 48.0 bits (109), Expect = 7e-05
Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 11/197 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V L FS D ++S S I I G++SGK + F ++ DG YI S +
Sbjct: 310 VTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASS 369
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHM---KLYDVVHANLA 125
DG + I+++ + +T + S + +S +LL + + + + VV N+
Sbjct: 370 DGTVKIWNMKTTECSNTFKSLG-STAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ 428
Query: 126 GTL-----SG--HASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVW 178
G + SG + A SP G+ D + + + + + T H V
Sbjct: 429 GQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI 488
Query: 179 GVKFNAESNKIISVSED 195
G+ + N I + SED
Sbjct: 489 GIAHHPHQNLIATYSED 505
Score = 38.3 bits (85), Expect = 0.059
Identities = 20/63 (31%), Positives = 30/63 (47%)
Query: 55 AYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHM 114
A SP G++I D ++ F GKL TL H + + P L+ T S+D +
Sbjct: 449 ALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDALL 508
Query: 115 KLY 117
KL+
Sbjct: 509 KLW 511
>AF208838-1|AAL34973.1| 410|Homo sapiens Miller-Dieker
lissencephaly protein protein.
Length = 410
Score = 96.7 bits (230), Expect = 2e-19
Identities = 64/240 (26%), Positives = 109/240 (45%), Gaps = 8/240 (3%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P ++S S I ++ E+G E+ L +++ GK +AS + D I
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
+ D + + T+ GH ++ S+ P+ +++ S D +K+++V T +GH
Sbjct: 176 LRDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV----WGVKFNAESNKI 189
WV V + DG S S D+TVRVW + + +C+ +EH V W + + S
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 190 ISVSEDK--GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ SE K G ++++G D +K+W L TL GH+ V V G+ I
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM--CLMTLVGHDNWVRGVLFHSGGKFI 353
Score = 87.4 bits (207), Expect = 1e-16
Identities = 77/343 (22%), Positives = 138/343 (40%), Gaps = 39/343 (11%)
Query: 84 HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPD 143
+ L GH + + F P ++++ S+D +K++D + TL GH V ++F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 144 GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYI 203
GK S SAD T+++ D +C T H+ V V P+ D+I
Sbjct: 162 GKLLASCSADMTIKLRDFQGFECIRTMHGHDHNVSSVAIM--------------PNGDHI 207
Query: 204 VTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXX 263
V+ D +K+W + + T GH V V + DG IA
Sbjct: 208 VSASRDKTIKMWEVQTG--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT 265
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
+ E++ + I ++P+ S + TG T GK
Sbjct: 266 KECKAELREHEHVVECISWAPESSYSSISEATGSET-------------KKSGK------ 306
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++ SG+ ++ ++DVS G L T+ H VR + F K + S ++D +
Sbjct: 307 ---PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 384 VYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRV 425
V++ ++ L+ H+ + S+ F + T + D +++V
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 83.4 bits (197), Expect = 2e-15
Identities = 46/143 (32%), Positives = 71/143 (49%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V + P + S + D I ++D G TL+GH S++ + F +LL + S D
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL D T+ GH V SVA P+G VS S D+T+++W++ + C TF H
Sbjct: 174 IKLRDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233
Query: 174 NDQVWGVKFNAESNKIISVSEDK 196
+ V V+ N + I S S D+
Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQ 256
Score = 79.8 bits (188), Expect = 2e-14
Identities = 61/228 (26%), Positives = 101/228 (44%), Gaps = 34/228 (14%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
+V ++ P+G H++S S I ++ V++G + ++ V + DG IAS +
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------------------LLLT 107
D + ++ VA + L H + + ++P+S LL+
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 108 GSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
GS D +K++DV TL GH +WV V F GK +S + D+T+RVWD + +C
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVW 215
T H V + F+ + Y+VTG +D VKVW
Sbjct: 374 KTLNAHEHFVTSLDFHKTA--------------PYVVTGSVDQTVKVW 407
Score = 75.8 bits (178), Expect = 3e-13
Identities = 58/294 (19%), Positives = 118/294 (40%), Gaps = 23/294 (7%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P +V+ D +KVW YE E TL+GH V ++ G+ +A
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR + ++ + P+G + + + ++ + G K +
Sbjct: 176 LRDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK------ 371
++ V + DG IAS + +V ++ V+ + + H V ++++P++
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 372 --------------LLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMAT 416
L S S D + ++++ + L + H W V F G+ + +
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 417 SAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
A D ++RV + R + T H H V + F+ +V+ S D+++ ++EC
Sbjct: 356 CADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409
Score = 67.3 bits (157), Expect = 1e-10
Identities = 32/101 (31%), Positives = 57/101 (56%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
G ++ SG+ D I ++DV+ G + TL GH +R + F + +L+ +DD ++++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+ TL+ H +V S+ F V+GS D+TV+VW+
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 60.9 bits (141), Expect = 1e-08
Identities = 32/119 (26%), Positives = 58/119 (48%), Gaps = 1/119 (0%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPD 410
+ + H V + F P ++ SAS D + V++ E+ + L H + F
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G+ +A+ +AD +I++ + F + T H H V V +G +VS S+DK+I ++E
Sbjct: 162 GKLLASCSADMTIKLRDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Score = 59.3 bits (137), Expect = 3e-08
Identities = 35/171 (20%), Positives = 77/171 (45%), Gaps = 1/171 (0%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S + +++F P S + + + V+ G ++ L + +++ G+ +AS
Sbjct: 109 SPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASC 168
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQ 393
+ ++ L D + + T+ H V S+A P + SAS D + ++ +++ ++
Sbjct: 169 SADMTIKLRDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK 228
Query: 394 NKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIV 444
H+ W V + DG +A+ + D ++RV ++ EH H+V
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
Score = 44.8 bits (101), Expect = 7e-04
Identities = 27/101 (26%), Positives = 48/101 (47%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV 77
G ++SGS I ++ V +G L + V + GK+I S A D + ++D
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ + TL H + SL F + ++TGS D +K+++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>M16538-1|AAA35922.1| 340|Homo sapiens protein ( Human
signal-transducing guanine nucleotide-binding regulatory
(G) protein beta subunit mRNA, complete cds. ).
Length = 340
Score = 96.3 bits (229), Expect = 2e-19
Identities = 50/194 (25%), Positives = 99/194 (51%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + + D + ++S S GK++I+ + + + R + ++ AY+ G ++A
Sbjct: 55 LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAXSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD I +I+ + +G ++ L GH + F D+Q++ T S D L+D+
Sbjct: 115 GGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQII-TSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
+GH+ V+S++ +P+G+ FVSG+ D ++++WD+ C+ TF H + V
Sbjct: 174 GQQTVGFAGHSGDVMSLSLAPNGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVA 233
Query: 182 FNAESNKIISVSED 195
F + S+D
Sbjct: 234 FFPNGYAFTTGSDD 247
Score = 76.2 bits (179), Expect = 2e-13
Identities = 43/155 (27%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +L +P+G+ +SG+ I ++ V Q +VA+ P+G +G+
Sbjct: 186 DVMSLSLAPNGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q L+++ + I S+ FS +LLL G DD + ++D + + A
Sbjct: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G L+GH + V + + DG +GS D +++W+
Sbjct: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
Score = 72.5 bits (170), Expect = 3e-12
Identities = 51/203 (25%), Positives = 92/203 (45%), Gaps = 18/203 (8%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D +I+ S ++ +E+G+Q +S++ +P+G+ SGA D I ++D
Sbjct: 153 DDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPNGRTFVSGACDASIKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V T GH I ++ F P+ TGSDD +L+D + A+ + H +
Sbjct: 213 VRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIIC 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ ++G D +WD H+++V + V+
Sbjct: 272 GITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRV----------SCLGVT 321
Query: 194 EDKGPSKDYIVTGGLDNLVKVWS 216
+D G + + TG D+ +K+W+
Sbjct: 322 DD-GMA---VATGSWDSFLKIWN 340
Score = 70.9 bits (166), Expect = 9e-12
Identities = 62/305 (20%), Positives = 124/305 (40%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ + DS+LL++ S DG + ++D N + +SWV++ A++ G
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAXSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D ++ L + +E N +V + + + S + + I+
Sbjct: 110 NFVACGGLDNICSIYSLKT-------REGNVRV-SRELPGHTGYL---SCCRFLDDNQII 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + GH V+S++++P+G T
Sbjct: 159 TSSGDTTCALWDIETGQQTV--GFAGHSGDVMSLSLAPNGRTFVSGACDASIKLWDVRDS 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ + F P+G TG ++ + + ++ + I S
Sbjct: 217 MCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LRADQELLMYSHDNIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D +G + H V L + +A+ S D +
Sbjct: 276 VAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 66.5 bits (155), Expect = 2e-10
Identities = 51/190 (26%), Positives = 89/190 (46%), Gaps = 14/190 (7%)
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
D I + + D ++D+ G+ GH+ + SL +P+ + ++G+ D +KL+D
Sbjct: 153 DDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPNGRTFVSGACDASIKLWD 212
Query: 119 VVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVW 178
V + T GH S + +VAF P+G F +GS D T R++DL + Q + H++ +
Sbjct: 213 VRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIIC 271
Query: 179 GVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSV 238
G+ A S S ++ G D +W + K + L GH+ V +
Sbjct: 272 GITSVAFSR-----------SGRLLLAGYDDFNCNIW--DAMKGDRAGVLAGHDNRVSCL 318
Query: 239 AVSPDGETIA 248
V+ DG +A
Sbjct: 319 GVTDDGMAVA 328
Score = 65.7 bits (153), Expect = 3e-10
Identities = 62/291 (21%), Positives = 120/291 (41%), Gaps = 16/291 (5%)
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N+I + G S +T GLD + ++ ++ TL GH + ++ D
Sbjct: 16 NQIRDARKACGDSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRL 69
Query: 247 IAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-- 304
+ K+ I SS + ++ G+ VA GG ++Y +
Sbjct: 70 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAXSGNFVACGGLDNICSIYSLKTR 129
Query: 305 --NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
N V + L ++ + D + I S + + L+D+ G+ H+ V
Sbjct: 130 EGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD-TTCALWDIETGQQTVGFAGHSGDVM 188
Query: 363 SLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
SL+ +P + S + D + ++++ +S Q + H+ +V F P+G T + D
Sbjct: 189 SLSLAPNGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVSVSKDKSINIYE 469
+ R+ L + L + H +I+CG V F+ G L++ D + NI++
Sbjct: 249 TCRLFDLRADQELLMY-SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
>L13387-1|AAA02882.1| 288|Homo sapiens Miller-Dieker lissencephaly
protein protein.
Length = 288
Score = 95.1 bits (226), Expect = 5e-19
Identities = 61/233 (26%), Positives = 107/233 (45%), Gaps = 8/233 (3%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
++S S I ++ E+G E+ L +++ GK +AS + D I ++D
Sbjct: 1 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 60
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ + T+ GH ++ S+ P+ +++ S D +K+++V T +GH WV V
Sbjct: 61 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 120
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV----WGVKFNAESNKIISVSEDK 196
+ DG S S D+TVRVW + + +C+ +EH V W + + S + SE K
Sbjct: 121 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 180
Query: 197 --GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
G ++++G D +K+W L T GH+ V V G+ I
Sbjct: 181 KSGKPGPFLLSGSRDKTIKMWDVSTGM--CLMTXVGHDNWVRGVLFHSGGKFI 231
Score = 77.8 bits (183), Expect = 8e-14
Identities = 60/228 (26%), Positives = 100/228 (43%), Gaps = 34/228 (14%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
+V ++ P+G H++S S I ++ V++G + ++ V + DG IAS +
Sbjct: 72 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 131
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------------------LLLT 107
D + ++ VA + L H + + ++P+S LL+
Sbjct: 132 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 191
Query: 108 GSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ 167
GS D +K++DV T GH +WV V F GK +S + D+T+RVWD + +C
Sbjct: 192 GSRDKTIKMWDVSTGMCLMTXVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 251
Query: 168 HTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVW 215
T H V + F+ + Y+VTG +D VKVW
Sbjct: 252 KTLNAHEHFVTSLDFHKTA--------------PYVVTGSVDQTVKVW 285
Score = 77.4 bits (182), Expect = 1e-13
Identities = 63/299 (21%), Positives = 122/299 (40%), Gaps = 37/299 (12%)
Query: 148 VSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGG 207
VS S D T++VWD ++ + T K H D V + F+ + S S D
Sbjct: 2 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADM----------- 50
Query: 208 LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI 267
+K+W ++ E + T+ GH+ V SVA+ P+G+ I G +
Sbjct: 51 ---TIKLWDFQG--FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV 105
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
+ + + + DG+ +A+ + V V+ + L + ++W+P+
Sbjct: 106 KTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPE 165
Query: 328 --------------------GRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
G ++ SG+ ++ ++DVS G L T H VR + F
Sbjct: 166 SSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTXVGHDNWVRGVLFH 225
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRV 425
K + S ++D + V++ ++ L+ H+ + S+ F + T + D +++V
Sbjct: 226 SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 284
Score = 75.4 bits (177), Expect = 4e-13
Identities = 57/289 (19%), Positives = 117/289 (40%), Gaps = 23/289 (7%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+V+ D +KVW YE E TL+GH V ++ G+ +A
Sbjct: 1 MVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 58
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
+ IR + ++ + P+G + + + ++ + G K +++ V
Sbjct: 59 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV 118
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK----------- 371
+ DG IAS + +V ++ V+ + + H V ++++P++
Sbjct: 119 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 178
Query: 372 ---------LLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADG 421
L S S D + ++++ + L + H W V F G+ + + A D
Sbjct: 179 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTXVGHDNWVRGVLFHSGGKFILSCADDK 238
Query: 422 SIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
++RV + R + T H H V + F+ +V+ S D+++ ++EC
Sbjct: 239 TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 287
Score = 65.3 bits (152), Expect = 5e-10
Identities = 31/101 (30%), Positives = 56/101 (55%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
G ++ SG+ D I ++DV+ G + T GH +R + F + +L+ +DD ++++D
Sbjct: 186 GPFLLSGSRDKTIKMWDVSTGMCLMTXVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 245
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+ TL+ H +V S+ F V+GS D+TV+VW+
Sbjct: 246 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 286
Score = 42.7 bits (96), Expect = 0.003
Identities = 26/101 (25%), Positives = 47/101 (46%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV 77
G ++SGS I ++ V +G + V + GK+I S A D + ++D
Sbjct: 186 GPFLLSGSRDKTIKMWDVSTGMCLMTXVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 245
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ + TL H + SL F + ++TGS D +K+++
Sbjct: 246 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 286
>BC117246-1|AAI17247.1| 707|Homo sapiens F-box and WD repeat domain
containing 7 protein.
Length = 707
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 446
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 447 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 552
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 553 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 581
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 529
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 585
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 586 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 643
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 434 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 491
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 492 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 591
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 592 NILVSGNADSTVKIWDIKTG--QCLQTLQG 619
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 568 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 625
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 626 AVTCLQFNKNFVITSSDDGTVKLWDL 651
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 544 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 599
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 600 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 394 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 449
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 450 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 508 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 563
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 564 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 622 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 650
>BC117244-1|AAI17245.1| 707|Homo sapiens F-box and WD repeat domain
containing 7 protein.
Length = 707
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 446
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 447 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 552
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 553 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 581
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 529
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 585
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 586 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 643
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 434 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 491
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 492 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 591
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 592 NILVSGNADSTVKIWDIKTG--QCLQTLQG 619
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 568 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 625
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 626 AVTCLQFNKNFVITSSDDGTVKLWDL 651
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 544 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 599
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 600 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 394 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 449
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 450 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 508 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 563
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 564 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 622 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 650
>BC113421-1|AAI13422.1| 514|Homo sapiens transducin (beta)-like
1X-linked receptor 1 protein.
Length = 514
Score = 94.7 bits (225), Expect = 6e-19
Identities = 84/368 (22%), Positives = 155/368 (42%), Gaps = 41/368 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT---LSGHA---------- 132
L GH + ++P S LL +GS D +++++ + +G+ + H
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 133 -SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ +G +GS D R+W D T +H ++ +K+N + N
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGN---- 279
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
+I++ G+D +W E H P + V T A
Sbjct: 280 ----------FILSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-SNNTFASCS 326
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
+ I+ Q ++++ I + P G+ +A+ + ++ +
Sbjct: 327 TDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHD 386
Query: 312 LDTRGKFIMSVAWSPDG---------RYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+DV +G +HT+ H + V
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP + LAS S D V+++N ++ AL + VC++ G ++ SA+DGS
Sbjct: 447 SVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGS 506
Query: 423 IRVVLLEE 430
+ V+ L +
Sbjct: 507 VCVLDLRK 514
Score = 88.2 bits (209), Expect = 6e-17
Identities = 78/360 (21%), Positives = 155/360 (43%), Gaps = 21/360 (5%)
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWG 179
N A L GH S V A++P SGS D T R+W+L + + H + G
Sbjct: 160 NKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGG 219
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ SNK ++ S D + TG D ++W+ + N L TL H+ P+ ++
Sbjct: 220 Q--DVPSNKDVT-SLDWNSEGTLLATGSYDGFARIWTKDGN---LASTLGQHKGPIFALK 273
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
+ G I G+ ++ S+ + + + + A+ +
Sbjct: 274 WNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIH 332
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V + K + ++ W P G +AS ++ ++ ++ + Q +H ++AH +
Sbjct: 333 VCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK 392
Query: 360 AVRSLAFSP---------KTKLLASASNDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSP 409
+ ++ +SP +LASAS D V +++++ + H+ SV FSP
Sbjct: 393 EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP 452
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG+ +A+ + D + + + ++H++ T + V +NA G K+ + + D S+ + +
Sbjct: 453 DGRYLASGSFDKCVHIWNTQTGALVHSY-RGTGGIFEVCWNAAGDKVGASASDGSVCVLD 511
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/197 (24%), Positives = 91/197 (46%), Gaps = 10/197 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
++ L ++ G ++S +I+ +G+ +Q L V + + + AS +
Sbjct: 269 IFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCST 327
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D I++ + Q + + T +GH + ++ + P LL + SDD +K++ + N L
Sbjct: 328 DMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL 387
Query: 129 SGHASWVLSVAFSPDGK---------RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
H + ++ +SP G S S D TVR+WD+D C HT +H + V+
Sbjct: 388 QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYS 447
Query: 180 VKFNAESNKIISVSEDK 196
V F+ + + S S DK
Sbjct: 448 VAFSPDGRYLASGSFDK 464
Score = 71.3 bits (167), Expect = 7e-12
Identities = 44/152 (28%), Positives = 77/152 (50%), Gaps = 10/152 (6%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------- 103
++ + P G +AS + D + I+ + Q VH L+ H I ++ +SP
Sbjct: 354 AIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANL 413
Query: 104 LLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDS 163
+L + S D ++L+DV TL+ H V SVAFSPDG+ SGS D+ V +W+ +
Sbjct: 414 MLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQT 473
Query: 164 MQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
H+++ ++ V +NA +K+ + + D
Sbjct: 474 GALVHSYR-GTGGIFEVCWNAAGDKVGASASD 504
Score = 70.1 bits (164), Expect = 2e-11
Identities = 69/307 (22%), Positives = 120/307 (39%), Gaps = 30/307 (9%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K S+ ++ +G +A+G+ DG I+ G L TL H I +L ++ +L+
Sbjct: 226 KDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
D ++D H++ L V + F S S D + V L +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
TF+ H ++V +K++ N + S S+D +K+WS + + +H L
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDM--------------TLKIWSMKQD--NCVHDL 387
Query: 229 EGHEMPVVSVAVSPDGE---------TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK 279
+ H + ++ SP G +A G I + ++
Sbjct: 388 QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYS 447
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRGKFIMSVAWSPDGRYIASGAEGG 338
+ FSPDG +A+G V ++ G V T G I V W+ G + + A G
Sbjct: 448 VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG--IFEVCWNAAGDKVGASASDG 505
Query: 339 SVYLFDV 345
SV + D+
Sbjct: 506 SVCVLDL 512
Score = 50.0 bits (114), Expect = 2e-05
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ V+ G L + SVA+SPDG+Y+ASG+ D ++I++ G L
Sbjct: 417 SASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGAL 476
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ G I +C++ + + DG + + D+
Sbjct: 477 VHSYRGTG-GIFEVCWNAAGDKVGASASDGSVCVLDL 512
Score = 32.7 bits (71), Expect = 2.9
Identities = 20/70 (28%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGK-QEQVLDTRGKFTLSVAYSPDGKYIASGA 67
V+++ FSPDG+++ SGS + I+ ++G T G F V ++ G + + A
Sbjct: 445 VYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIF--EVCWNAAGDKVGASA 502
Query: 68 LDGIINIFDV 77
DG + + D+
Sbjct: 503 SDGSVCVLDL 512
>BC037320-1|AAH37320.1| 621|Homo sapiens FBXW7 protein protein.
Length = 621
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 305 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 360
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 361 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 418
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 419 RCVRY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 466
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 467 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 495
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 386 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVRY--DGRRVVSGAYDFMVKVWDPE 443
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 444 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 499
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 500 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 557
Score = 86.2 bits (204), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 348 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 405
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 406 QCLHVLMGHVAAVR--CVRYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 463
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 464 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 505
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 506 NILVSGNADSTVKIWDIKTG--QCLQTLQG 533
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 424 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 481
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 482 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 539
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 540 AVTCLQFNKNFVITSSDDGTVKLWDL 565
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 458 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 513
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 514 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 565
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 308 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 363
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 364 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 421
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 422 RY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 477
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 478 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 535
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 536 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 564
>AY049984-1|AAL07271.1| 707|Homo sapiens F-box protein CDC4
protein.
Length = 707
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 446
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 447 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 552
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 553 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 581
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 529
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 585
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 586 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 643
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 434 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 491
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 492 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 591
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 592 NILVSGNADSTVKIWDIKTG--QCLQTLQG 619
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 568 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 625
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 626 AVTCLQFNKNFVITSSDDGTVKLWDL 651
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 544 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 599
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 600 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 394 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 449
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 450 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 508 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 563
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 564 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 622 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 650
>AY033553-1|AAK57547.1| 627|Homo sapiens F-box protein FBW7
protein.
Length = 627
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 366
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 367 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 424
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 425 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 472
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 473 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 501
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 392 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 449
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 450 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 505
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 506 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 563
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 354 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 411
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 412 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 469
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 470 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 511
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 512 NILVSGNADSTVKIWDIKTG--QCLQTLQG 539
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 487
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 488 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 545
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 546 AVTCLQFNKNFVITSSDDGTVKLWDL 571
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 464 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 519
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 520 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 314 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 369
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 370 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 428 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 483
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 484 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 541
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 542 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 570
>AY008274-1|AAG16640.1| 589|Homo sapiens F-box protein SEL10
protein.
Length = 589
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 328
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 329 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 386
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 387 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 434
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 435 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 463
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 354 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 411
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 412 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 467
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 468 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 525
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 316 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 373
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 374 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 431
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 432 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 473
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 474 NILVSGNADSTVKIWDIKTG--QCLQTLQG 501
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 450 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 507
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 508 AVTCLQFNKNFVITSSDDGTVKLWDL 533
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 426 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 481
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 482 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 533
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 276 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 331
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 332 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 389
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 390 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 445
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 446 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 503
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 504 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 532
>AK223449-1|BAD97169.1| 627|Homo sapiens F-box protein FBW7 isoform
2 variant protein.
Length = 627
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 366
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 367 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 424
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 425 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 472
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 473 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 501
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 392 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 449
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 450 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 505
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 506 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 563
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 354 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 411
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 412 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 469
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 470 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 511
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 512 NILVSGNADSTVKIWDIKTG--QCLQTLQG 539
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 487
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 488 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 545
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 546 AVTCLQFNKNFVITSSDDGTVKLWDL 571
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 464 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 519
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 520 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 314 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 369
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 370 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 428 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 483
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 484 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 541
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 542 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 570
>AK022956-1|BAB14331.1| 514|Homo sapiens protein ( Homo sapiens
cDNA FLJ12894 fis, clone NT2RP2004170, moderately
similar to Homo sapiens mRNA for transducin (beta) like
1 protein. ).
Length = 514
Score = 94.7 bits (225), Expect = 6e-19
Identities = 84/368 (22%), Positives = 155/368 (42%), Gaps = 41/368 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT---LSGHA---------- 132
L GH + ++P S LL +GS D +++++ + +G+ + H
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 133 -SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ +G +GS D R+W D T +H ++ +K+N + N
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGN---- 279
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
+I++ G+D +W E H P + V T A
Sbjct: 280 ----------FILSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-SNNTFASCS 326
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
+ I+ Q ++++ I + P G+ +A+ + ++ +
Sbjct: 327 TDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHD 386
Query: 312 LDTRGKFIMSVAWSPDG---------RYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+DV +G +HT+ H + V
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP + LAS S D V+++N ++ AL + VC++ G ++ SA+DGS
Sbjct: 447 SVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGS 506
Query: 423 IRVVLLEE 430
+ V+ L +
Sbjct: 507 VCVLDLRK 514
Score = 88.2 bits (209), Expect = 6e-17
Identities = 78/360 (21%), Positives = 155/360 (43%), Gaps = 21/360 (5%)
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWG 179
N A L GH S V A++P SGS D T R+W+L + + H + G
Sbjct: 160 NKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGG 219
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ SNK ++ S D + TG D ++W+ + N L TL H+ P+ ++
Sbjct: 220 Q--DVPSNKDVT-SLDWNSEGTLLATGSYDGFARIWTKDGN---LASTLGQHKGPIFALK 273
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
+ G I G+ ++ S+ + + + + A+ +
Sbjct: 274 WNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIH 332
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V + K + ++ W P G +AS ++ ++ ++ + Q +H ++AH +
Sbjct: 333 VCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK 392
Query: 360 AVRSLAFSP---------KTKLLASASNDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSP 409
+ ++ +SP +LASAS D V +++++ + H+ SV FSP
Sbjct: 393 EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP 452
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG+ +A+ + D + + + ++H++ T + V +NA G K+ + + D S+ + +
Sbjct: 453 DGRYLASGSFDKCVHIWNTQTGALVHSY-RGTGGIFEVCWNAAGDKVGASASDGSVCVLD 511
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/197 (24%), Positives = 91/197 (46%), Gaps = 10/197 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
++ L ++ G ++S +I+ +G+ +Q L V + + + AS +
Sbjct: 269 IFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCST 327
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D I++ + Q + + T +GH + ++ + P LL + SDD +K++ + N L
Sbjct: 328 DMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL 387
Query: 129 SGHASWVLSVAFSPDGK---------RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
H + ++ +SP G S S D TVR+WD+D C HT +H + V+
Sbjct: 388 QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYS 447
Query: 180 VKFNAESNKIISVSEDK 196
V F+ + + S S DK
Sbjct: 448 VAFSPDGRYLASGSFDK 464
Score = 71.3 bits (167), Expect = 7e-12
Identities = 44/152 (28%), Positives = 77/152 (50%), Gaps = 10/152 (6%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------- 103
++ + P G +AS + D + I+ + Q VH L+ H I ++ +SP
Sbjct: 354 AIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANL 413
Query: 104 LLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDS 163
+L + S D ++L+DV TL+ H V SVAFSPDG+ SGS D+ V +W+ +
Sbjct: 414 MLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQT 473
Query: 164 MQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
H+++ ++ V +NA +K+ + + D
Sbjct: 474 GALVHSYR-GTGGIFEVCWNAAGDKVGASASD 504
Score = 70.1 bits (164), Expect = 2e-11
Identities = 69/307 (22%), Positives = 120/307 (39%), Gaps = 30/307 (9%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K S+ ++ +G +A+G+ DG I+ G L TL H I +L ++ +L+
Sbjct: 226 KDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
D ++D H++ L V + F S S D + V L +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
TF+ H ++V +K++ N + S S+D +K+WS + + +H L
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDM--------------TLKIWSMKQD--NCVHDL 387
Query: 229 EGHEMPVVSVAVSPDGE---------TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK 279
+ H + ++ SP G +A G I + ++
Sbjct: 388 QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYS 447
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRGKFIMSVAWSPDGRYIASGAEGG 338
+ FSPDG +A+G V ++ G V T G I V W+ G + + A G
Sbjct: 448 VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG--IFEVCWNAAGDKVGASASDG 505
Query: 339 SVYLFDV 345
SV + D+
Sbjct: 506 SVCVLDL 512
Score = 50.0 bits (114), Expect = 2e-05
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ V+ G L + SVA+SPDG+Y+ASG+ D ++I++ G L
Sbjct: 417 SASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGAL 476
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ G I +C++ + + DG + + D+
Sbjct: 477 VHSYRGTG-GIFEVCWNAAGDKVGASASDGSVCVLDL 512
Score = 32.7 bits (71), Expect = 2.9
Identities = 20/70 (28%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGK-QEQVLDTRGKFTLSVAYSPDGKYIASGA 67
V+++ FSPDG+++ SGS + I+ ++G T G F V ++ G + + A
Sbjct: 445 VYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIF--EVCWNAAGDKVGASA 502
Query: 68 LDGIINIFDV 77
DG + + D+
Sbjct: 503 SDGSVCVLDL 512
>AK001933-1|BAA91986.1| 553|Homo sapiens protein ( Homo sapiens
cDNA FLJ11071 fis, clone PLACE1004937, moderately
similar to SEL-10 PROTEIN. ).
Length = 553
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 237 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 292
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 293 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 350
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 351 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 398
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 399 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 427
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 318 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 375
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 376 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 431
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 432 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 489
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 280 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 337
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 338 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 395
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 396 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 437
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 438 NILVSGNADSTVKIWDIKTG--QCLQTLQG 465
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 356 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 413
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 414 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 471
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 472 AVTCLQFNKNFVITSSDDGTVKLWDL 497
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 390 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 445
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 446 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 497
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 240 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 295
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 296 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 353
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 354 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 409
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 410 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 467
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 468 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 496
>AF411972-1|AAL06291.1| 627|Homo sapiens archipelago beta form
protein.
Length = 627
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 366
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 367 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 424
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 425 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 472
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 473 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 501
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 392 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 449
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 450 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 505
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 506 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 563
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 354 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 411
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 412 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 469
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 470 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 511
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 512 NILVSGNADSTVKIWDIKTG--QCLQTLQG 539
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 487
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 488 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 545
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 546 AVTCLQFNKNFVITSSDDGTVKLWDL 571
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 464 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 519
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 520 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 314 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 369
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 370 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 428 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 483
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 484 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 541
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 542 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 570
>AF411971-1|AAL06290.1| 707|Homo sapiens archipelago alpha form
protein.
Length = 707
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 446
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 447 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 552
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 553 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 581
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 529
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 585
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 586 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 643
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 434 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 491
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 492 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 591
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 592 NILVSGNADSTVKIWDIKTG--QCLQTLQG 619
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 568 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 625
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 626 AVTCLQFNKNFVITSSDDGTVKLWDL 651
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 544 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 599
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 600 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 394 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 449
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 450 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 508 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 563
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 564 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 622 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 650
>AF383178-1|AAK60269.1| 561|Homo sapiens F-box protein FBX30
protein.
Length = 561
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 245 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 300
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 301 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 358
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 359 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 406
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 407 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 435
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 326 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 383
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 384 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 439
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 440 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 497
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 288 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 345
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 346 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 403
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 404 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 445
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 446 NILVSGNADSTVKIWDIKTG--QCLQTLQG 473
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 364 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 421
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 422 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 479
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 480 AVTCLQFNKNFVITSSDDGTVKLWDL 505
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 398 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 453
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 454 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 505
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 248 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 303
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 304 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 361
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 362 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 417
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 418 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 475
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 476 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 504
>AF314544-1|AAK00301.1| 514|Homo sapiens nuclear receptor
co-repressor/HDAC3 complex subunit TBLR1 protein.
Length = 514
Score = 94.7 bits (225), Expect = 6e-19
Identities = 84/368 (22%), Positives = 155/368 (42%), Gaps = 41/368 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT---LSGHA---------- 132
L GH + ++P S LL +GS D +++++ + +G+ + H
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 133 -SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ +G +GS D R+W D T +H ++ +K+N + N
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGN---- 279
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
+I++ G+D +W E H P + V T A
Sbjct: 280 ----------FILSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-SNNTFASCS 326
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
+ I+ Q ++++ I + P G+ +A+ + ++ +
Sbjct: 327 TDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHD 386
Query: 312 LDTRGKFIMSVAWSPDG---------RYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+DV +G +HT+ H + V
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP + LAS S D V+++N ++ AL + VC++ G ++ SA+DGS
Sbjct: 447 SVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGS 506
Query: 423 IRVVLLEE 430
+ V+ L +
Sbjct: 507 VCVLDLRK 514
Score = 88.2 bits (209), Expect = 6e-17
Identities = 78/360 (21%), Positives = 155/360 (43%), Gaps = 21/360 (5%)
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWG 179
N A L GH S V A++P SGS D T R+W+L + + H + G
Sbjct: 160 NKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGG 219
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ SNK ++ S D + TG D ++W+ + N L TL H+ P+ ++
Sbjct: 220 Q--DVPSNKDVT-SLDWNSEGTLLATGSYDGFARIWTKDGN---LASTLGQHKGPIFALK 273
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
+ G I G+ ++ S+ + + + + A+ +
Sbjct: 274 WNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIH 332
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V + K + ++ W P G +AS ++ ++ ++ + Q +H ++AH +
Sbjct: 333 VCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK 392
Query: 360 AVRSLAFSP---------KTKLLASASNDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSP 409
+ ++ +SP +LASAS D V +++++ + H+ SV FSP
Sbjct: 393 EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP 452
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG+ +A+ + D + + + ++H++ T + V +NA G K+ + + D S+ + +
Sbjct: 453 DGRYLASGSFDKCVHIWNTQTGALVHSY-RGTGGIFEVCWNAAGDKVGASASDGSVCVLD 511
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/197 (24%), Positives = 91/197 (46%), Gaps = 10/197 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
++ L ++ G ++S +I+ +G+ +Q L V + + + AS +
Sbjct: 269 IFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCST 327
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
D I++ + Q + + T +GH + ++ + P LL + SDD +K++ + N L
Sbjct: 328 DMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL 387
Query: 129 SGHASWVLSVAFSPDGK---------RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
H + ++ +SP G S S D TVR+WD+D C HT +H + V+
Sbjct: 388 QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYS 447
Query: 180 VKFNAESNKIISVSEDK 196
V F+ + + S S DK
Sbjct: 448 VAFSPDGRYLASGSFDK 464
Score = 71.3 bits (167), Expect = 7e-12
Identities = 44/152 (28%), Positives = 77/152 (50%), Gaps = 10/152 (6%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--------- 103
++ + P G +AS + D + I+ + Q VH L+ H I ++ +SP
Sbjct: 354 AIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANL 413
Query: 104 LLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDS 163
+L + S D ++L+DV TL+ H V SVAFSPDG+ SGS D+ V +W+ +
Sbjct: 414 MLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQT 473
Query: 164 MQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
H+++ ++ V +NA +K+ + + D
Sbjct: 474 GALVHSYR-GTGGIFEVCWNAAGDKVGASASD 504
Score = 70.1 bits (164), Expect = 2e-11
Identities = 69/307 (22%), Positives = 120/307 (39%), Gaps = 30/307 (9%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K S+ ++ +G +A+G+ DG I+ G L TL H I +L ++ +L+
Sbjct: 226 KDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
D ++D H++ L V + F S S D + V L +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
TF+ H ++V +K++ N + S S+D +K+WS + + +H L
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDM--------------TLKIWSMKQD--NCVHDL 387
Query: 229 EGHEMPVVSVAVSPDGE---------TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK 279
+ H + ++ SP G +A G I + ++
Sbjct: 388 QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYS 447
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRGKFIMSVAWSPDGRYIASGAEGG 338
+ FSPDG +A+G V ++ G V T G I V W+ G + + A G
Sbjct: 448 VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG--IFEVCWNAAGDKVGASASDG 505
Query: 339 SVYLFDV 345
SV + D+
Sbjct: 506 SVCVLDL 512
Score = 50.0 bits (114), Expect = 2e-05
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ V+ G L + SVA+SPDG+Y+ASG+ D ++I++ G L
Sbjct: 417 SASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGAL 476
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ G I +C++ + + DG + + D+
Sbjct: 477 VHSYRGTG-GIFEVCWNAAGDKVGASASDGSVCVLDL 512
Score = 32.7 bits (71), Expect = 2.9
Identities = 20/70 (28%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGK-QEQVLDTRGKFTLSVAYSPDGKYIASGA 67
V+++ FSPDG+++ SGS + I+ ++G T G F V ++ G + + A
Sbjct: 445 VYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIF--EVCWNAAGDKVGASA 502
Query: 68 LDGIINIFDV 77
DG + + D+
Sbjct: 503 SDGSVCVLDL 512
>AB209725-1|BAD92962.1| 624|Homo sapiens F-box protein FBW7 isoform
2 variant protein.
Length = 624
Score = 94.7 bits (225), Expect = 6e-19
Identities = 59/217 (27%), Positives = 109/217 (50%), Gaps = 28/217 (12%)
Query: 18 GKHVISGSNAGKILIFGVESGKQEQVL--DTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
G ++SGS+ + ++ +GK + L T G ++ + I SG+ D + ++
Sbjct: 308 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR----DNIIISGSTDRTLKVW 363
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
+ G+ +HTL GH ++R C + +++GS D ++++D+ L GH + V
Sbjct: 364 NAETGECIHTLYGHTSTVR--CMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAV 421
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V + DG+R VSG+ D V+VWD ++ C HT + H ++V+ ++F+
Sbjct: 422 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI---------- 469
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHE 232
++V+G LD ++VW E +HTL GH+
Sbjct: 470 ------HVVSGSLDTSIRVWDVETG--NCIHTLTGHQ 498
Score = 90.6 bits (215), Expect = 1e-17
Identities = 59/180 (32%), Positives = 96/180 (53%), Gaps = 11/180 (6%)
Query: 19 KHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVA 78
K V+SGS + ++ +E+G+ VL V Y DG+ + SGA D ++ ++D
Sbjct: 389 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE 446
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
+HTL+GH + SL F D +++GS D ++++DV N TL+GH S L+
Sbjct: 447 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTS 502
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWGVKFNAESNKIISVSED 195
VSG+AD TV++WD+ + QC T + +H V ++FN N +I+ S+D
Sbjct: 503 GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDD 560
Score = 86.6 bits (205), Expect = 2e-16
Identities = 58/210 (27%), Positives = 100/210 (47%), Gaps = 24/210 (11%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
+ISGS + ++ E+G E + G + K + SG+ D + ++D+ G
Sbjct: 351 IISGSTDRTLKVWNAETG--ECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETG 408
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +H L GH ++R C D + +++G+ D +K++D TL GH + V S+ F
Sbjct: 409 QCLHVLMGHVAAVR--CVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 466
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
DG VSGS D ++RVWD+++ C HT H G++
Sbjct: 467 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----------------KD 508
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
+ +V+G D+ VK+W + + L TL+G
Sbjct: 509 NILVSGNADSTVKIWDIKTG--QCLQTLQG 536
Score = 66.5 bits (155), Expect = 2e-10
Identities = 45/146 (30%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
DG+ V+SG+ + ++ E+ L S+ + DG ++ SG+LD I ++D
Sbjct: 427 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 484
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVL 136
V G +HTL GH S+ S D+ +L++G+ D +K++D+ TL G
Sbjct: 485 VETGNCIHTLTGH-QSLTSGMELKDN-ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQS 542
Query: 137 SVAFSPDGKRFV-SGSADRTVRVWDL 161
+V K FV + S D TV++WDL
Sbjct: 543 AVTCLQFNKNFVITSSDDGTVKLWDL 568
Score = 55.2 bits (127), Expect = 5e-07
Identities = 37/114 (32%), Positives = 61/114 (53%), Gaps = 9/114 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V++L F DG HV+SGS I ++ VE+G L G +L+ + SG
Sbjct: 461 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT--GHQSLTSGMELKDNILVSGNA 516
Query: 69 DGIINIFDVAQGKLVHTLEG---HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
D + I+D+ G+ + TL+G H ++ L F+ + ++T SDDG +KL+D+
Sbjct: 517 DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 568
Score = 50.0 bits (114), Expect = 2e-05
Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 18/271 (6%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
IV+G DN +KVWS K L TL GH V S + + I
Sbjct: 311 IVSGSDDNTLKVWSAVTGKC--LRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 366
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSV 322
G+ I + +S + + +V +G + V+ I G VL + V
Sbjct: 367 TGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 424
Query: 323 AWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYV 382
+ DGR + SGA V ++D LHT++ H V SL F + S S D +
Sbjct: 425 QY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSI 480
Query: 383 NVYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFE--- 438
V+++E+ + H+ +++ + + AD ++++ ++ + L T +
Sbjct: 481 RVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 538
Query: 439 EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+H V +QFN + +++ S D ++ +++
Sbjct: 539 KHQSAVTCLQFNK--NFVITSSDDGTVKLWD 567
>AF268193-1|AAG44736.1| 514|Homo sapiens IRA1 protein.
Length = 514
Score = 94.3 bits (224), Expect = 9e-19
Identities = 84/368 (22%), Positives = 155/368 (42%), Gaps = 41/368 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT---LSGHA---------- 132
L GH + ++P S LL +GS D +++++ + +G+ + H
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 133 -SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ +G +GS D R+W D T +H ++ +K+N + N
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGN---- 279
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
+I++ G+D +W E H P + V T A
Sbjct: 280 ----------FILSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-SNNTFASCS 326
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
+ I+ Q ++++ I + P G+ +A+ + ++ +
Sbjct: 327 TDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHD 386
Query: 312 LDTRGKFIMSVAWSPDG---------RYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+DV +G +HT+ H + V
Sbjct: 387 LQQHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP + LAS S D V+++N ++ AL + VC++ G ++ SA+DGS
Sbjct: 447 SVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGS 506
Query: 423 IRVVLLEE 430
+ V+ L +
Sbjct: 507 VCVLDLRK 514
Score = 86.2 bits (204), Expect = 2e-16
Identities = 77/360 (21%), Positives = 154/360 (42%), Gaps = 21/360 (5%)
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK---EHNDQVWG 179
N A L GH S V A++P SGS D T R+W+L + + H + G
Sbjct: 160 NKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGG 219
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ SNK ++ S D + TG D ++W+ + N L TL H+ P+ ++
Sbjct: 220 Q--DVPSNKDVT-SLDWNSEGTLLATGSYDGFARIWTKDGN---LASTLGQHKGPIFALK 273
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
+ G I G+ ++ S+ + + + + A+ +
Sbjct: 274 WNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIH 332
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V + K + ++ W P G +AS ++ ++ ++ + Q +H ++ H +
Sbjct: 333 VCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQQHNK 392
Query: 360 AVRSLAFSP---------KTKLLASASNDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSP 409
+ ++ +SP +LASAS D V +++++ + H+ SV FSP
Sbjct: 393 EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP 452
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG+ +A+ + D + + + ++H++ T + V +NA G K+ + + D S+ + +
Sbjct: 453 DGRYLASGSFDKCVHIWNTQTGALVHSY-RGTGGIFEVCWNAAGDKVGASASDGSVCVLD 511
Score = 81.0 bits (191), Expect = 8e-15
Identities = 60/293 (20%), Positives = 122/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ +G + +GS G I+ + G L ++ ++ G +I S
Sbjct: 227 DVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAG 285
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + T
Sbjct: 286 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFA-SCSTDMCIHVCKLGQDRPIKT 344
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H ++HN +++ +K++
Sbjct: 345 FQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQQHNKEIYTIKWSP--- 401
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ + + + D+ V++W + +HTL H+ PV SVA SPDG +
Sbjct: 402 --TGPGTNNPNANLMLASASFDSTVRLWDVDRG--ICIHTLTKHQEPVYSVAFSPDGRYL 457
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + + + ++++ ++ G +V G V V
Sbjct: 458 ASGSFDKCVHIWNTQTGALVHSYR-GTGGIFEVCWNAAGDKVGASASDGSVCV 509
Score = 69.3 bits (162), Expect = 3e-11
Identities = 69/307 (22%), Positives = 120/307 (39%), Gaps = 30/307 (9%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTG 108
K S+ ++ +G +A+G+ DG I+ G L TL H I +L ++ +L+
Sbjct: 226 KDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 109 SDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH 168
D ++D H++ L V + F S S D + V L +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343
Query: 169 TFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL 228
TF+ H ++V +K++ N + S S+D +K+WS + + +H L
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDM--------------TLKIWSMKQD--NCVHDL 387
Query: 229 EGHEMPVVSVAVSPDGE---------TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK 279
+ H + ++ SP G +A G I + ++
Sbjct: 388 QQHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYS 447
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRGKFIMSVAWSPDGRYIASGAEGG 338
+ FSPDG +A+G V ++ G V T G I V W+ G + + A G
Sbjct: 448 VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG--IFEVCWNAAGDKVGASASDG 505
Query: 339 SVYLFDV 345
SV + D+
Sbjct: 506 SVCVLDL 512
>Y12050-1|CAA72779.1| 340|Homo sapiens guanine nucleotide-binding
protein beta3 subunit protein.
Length = 340
Score = 93.9 bits (223), Expect = 1e-18
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 115 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F I + S+D
Sbjct: 234 FFPNGEAICTGSDD 247
Score = 83.0 bits (196), Expect = 2e-15
Identities = 51/182 (28%), Positives = 86/182 (47%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V +G T GH I ++CF P+ + + TGSDD +L+D + A+ H S
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIIC 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ +G D VWD + H+++V + A+ + + S
Sbjct: 272 GITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 331
Query: 194 ED 195
D
Sbjct: 332 WD 333
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 110 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ I F P+G + TG ++ + + + + I S
Sbjct: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D + + + + H V L + +A+ S D +
Sbjct: 276 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 72.1 bits (169), Expect = 4e-12
Identities = 57/251 (22%), Positives = 102/251 (40%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G+ + T + D S R+ L + L F H I+CG V F+ G L +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 67.7 bits (158), Expect = 8e-11
Identities = 42/155 (27%), Positives = 72/155 (46%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D +L SPD ISG+ ++ V G Q ++ + P+G+ I +G+
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q + + E I S+ FS +LL G DD + ++D + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G LSGH + V + + DG +GS D +++W+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 66.5 bits (155), Expect = 2e-10
Identities = 64/306 (20%), Positives = 126/306 (41%), Gaps = 24/306 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ ++ D K VS S D + VWD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +++ GGLDN+ +++ ++ + +++ L H +S D
Sbjct: 106 ----------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAH-TGYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D + SPD + +G ++ +
Sbjct: 155 NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
GT + I ++ + P+G I +G++ S LFD+ Q + + E+ +
Sbjct: 215 EGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
S+AFS +LL + +D NV++ E + + D++ + V + DG +AT +
Sbjct: 275 SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSW 332
Query: 420 DGSIRV 425
D +++
Sbjct: 333 DSFLKI 338
Score = 56.8 bits (131), Expect = 2e-07
Identities = 62/274 (22%), Positives = 107/274 (39%), Gaps = 12/274 (4%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 70 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 126
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 127 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 185
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
MS+A SPD SGA S L+DV +G T H + ++ F P + + + S
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 378 NDGYVNVYNIESAALQNKLDHK---CWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
+D ++++ + H+ C SV FS G+ + D + V + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
H + V + ADG + + S D + I+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/207 (19%), Positives = 88/207 (42%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G + + S D S +++
Sbjct: 228 DINAICFFPNGEAICTGSDDASCRLFD 254
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/115 (25%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF---TLSVAYSPDGKYI 63
+D+ + F P+G+ + +GS+ +F + + QE + + SVA+S G+ +
Sbjct: 227 SDINAICFFPNGEAICTGSDDASCRLFDLRA-DQELICFSHESIICGITSVAFSLSGRLL 285
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+G D N++D + + V L GH + L + D + TGS D +K+++
Sbjct: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>U47924-5|AAB51313.1| 340|Homo sapiens G-protein beta-3 chain
protein.
Length = 340
Score = 93.9 bits (223), Expect = 1e-18
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 115 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F I + S+D
Sbjct: 234 FFPNGEAICTGSDD 247
Score = 83.0 bits (196), Expect = 2e-15
Identities = 51/182 (28%), Positives = 86/182 (47%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V +G T GH I ++CF P+ + + TGSDD +L+D + A+ H S
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIIC 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ +G D VWD + H+++V + A+ + + S
Sbjct: 272 GITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 331
Query: 194 ED 195
D
Sbjct: 332 WD 333
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 110 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ I F P+G + TG ++ + + + + I S
Sbjct: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D + + + + H V L + +A+ S D +
Sbjct: 276 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 72.1 bits (169), Expect = 4e-12
Identities = 57/251 (22%), Positives = 102/251 (40%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G+ + T + D S R+ L + L F H I+CG V F+ G L +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 67.7 bits (158), Expect = 8e-11
Identities = 42/155 (27%), Positives = 72/155 (46%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D +L SPD ISG+ ++ V G Q ++ + P+G+ I +G+
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q + + E I S+ FS +LL G DD + ++D + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G LSGH + V + + DG +GS D +++W+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 66.5 bits (155), Expect = 2e-10
Identities = 64/306 (20%), Positives = 126/306 (41%), Gaps = 24/306 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ ++ D K VS S D + VWD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +++ GGLDN+ +++ ++ + +++ L H +S D
Sbjct: 106 ----------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAH-TGYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D + SPD + +G ++ +
Sbjct: 155 NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
GT + I ++ + P+G I +G++ S LFD+ Q + + E+ +
Sbjct: 215 EGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
S+AFS +LL + +D NV++ E + + D++ + V + DG +AT +
Sbjct: 275 SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSW 332
Query: 420 DGSIRV 425
D +++
Sbjct: 333 DSFLKI 338
Score = 56.8 bits (131), Expect = 2e-07
Identities = 62/274 (22%), Positives = 107/274 (39%), Gaps = 12/274 (4%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 70 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 126
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 127 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 185
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
MS+A SPD SGA S L+DV +G T H + ++ F P + + + S
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 378 NDGYVNVYNIESAALQNKLDHK---CWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
+D ++++ + H+ C SV FS G+ + D + V + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
H + V + ADG + + S D + I+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/207 (19%), Positives = 88/207 (42%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G + + S D S +++
Sbjct: 228 DINAICFFPNGEAICTGSDDASCRLFD 254
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/115 (25%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF---TLSVAYSPDGKYI 63
+D+ + F P+G+ + +GS+ +F + + QE + + SVA+S G+ +
Sbjct: 227 SDINAICFFPNGEAICTGSDDASCRLFDLRA-DQELICFSHESIICGITSVAFSLSGRLL 285
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+G D N++D + + V L GH + L + D + TGS D +K+++
Sbjct: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>M31328-1|AAA52582.1| 340|Homo sapiens GNB3 protein.
Length = 340
Score = 93.9 bits (223), Expect = 1e-18
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 115 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F I + S+D
Sbjct: 234 FFPNGEAICTGSDD 247
Score = 83.0 bits (196), Expect = 2e-15
Identities = 51/182 (28%), Positives = 86/182 (47%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V +G T GH I ++CF P+ + + TGSDD +L+D + A+ H S
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIIC 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ +G D VWD + H+++V + A+ + + S
Sbjct: 272 GITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 331
Query: 194 ED 195
D
Sbjct: 332 WD 333
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 110 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ I F P+G + TG ++ + + + + I S
Sbjct: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D + + + + H V L + +A+ S D +
Sbjct: 276 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 72.1 bits (169), Expect = 4e-12
Identities = 57/251 (22%), Positives = 102/251 (40%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G+ + T + D S R+ L + L F H I+CG V F+ G L +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 67.7 bits (158), Expect = 8e-11
Identities = 42/155 (27%), Positives = 72/155 (46%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D +L SPD ISG+ ++ V G Q ++ + P+G+ I +G+
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q + + E I S+ FS +LL G DD + ++D + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G LSGH + V + + DG +GS D +++W+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 66.5 bits (155), Expect = 2e-10
Identities = 64/306 (20%), Positives = 126/306 (41%), Gaps = 24/306 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ ++ D K VS S D + VWD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +++ GGLDN+ +++ ++ + +++ L H +S D
Sbjct: 106 ----------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAH-TGYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D + SPD + +G ++ +
Sbjct: 155 NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
GT + I ++ + P+G I +G++ S LFD+ Q + + E+ +
Sbjct: 215 EGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
S+AFS +LL + +D NV++ E + + D++ + V + DG +AT +
Sbjct: 275 SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSW 332
Query: 420 DGSIRV 425
D +++
Sbjct: 333 DSFLKI 338
Score = 56.8 bits (131), Expect = 2e-07
Identities = 62/274 (22%), Positives = 107/274 (39%), Gaps = 12/274 (4%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 70 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 126
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 127 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 185
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
MS+A SPD SGA S L+DV +G T H + ++ F P + + + S
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 378 NDGYVNVYNIESAALQNKLDHK---CWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
+D ++++ + H+ C SV FS G+ + D + V + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
H + V + ADG + + S D + I+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/207 (19%), Positives = 88/207 (42%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G + + S D S +++
Sbjct: 228 DINAICFFPNGEAICTGSDDASCRLFD 254
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/115 (25%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF---TLSVAYSPDGKYI 63
+D+ + F P+G+ + +GS+ +F + + QE + + SVA+S G+ +
Sbjct: 227 SDINAICFFPNGEAICTGSDDASCRLFDLRA-DQELICFSHESIICGITSVAFSLSGRLL 285
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+G D N++D + + V L GH + L + D + TGS D +K+++
Sbjct: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BT009800-1|AAP88802.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 3 protein.
Length = 340
Score = 93.9 bits (223), Expect = 1e-18
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 115 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F I + S+D
Sbjct: 234 FFPNGEAICTGSDD 247
Score = 82.6 bits (195), Expect = 3e-15
Identities = 51/182 (28%), Positives = 86/182 (47%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V +G T GH I ++CF P+ + + TGSDD +L+D + A+ H S
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIIC 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ +G D VWD + H+++V + A+ + + S
Sbjct: 272 SITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 331
Query: 194 ED 195
D
Sbjct: 332 WD 333
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 110 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ I F P+G + TG ++ + + + + I S
Sbjct: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIICSITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D + + + + H V L + +A+ S D +
Sbjct: 276 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 69.7 bits (163), Expect = 2e-11
Identities = 56/251 (22%), Positives = 101/251 (40%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVC---GVQFNADGSKLVS 458
++CF P+G+ + T + D S R+ L + L F H I+C V F+ G L +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICSITSVAFSLSGRLLFA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 69.3 bits (162), Expect = 3e-11
Identities = 43/155 (27%), Positives = 73/155 (47%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D +L SPD ISG+ ++ V G Q ++ + P+G+ I +G+
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q + + E SI S+ FS +LL G DD + ++D + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICSITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G LSGH + V + + DG +GS D +++W+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 66.9 bits (156), Expect = 1e-10
Identities = 64/306 (20%), Positives = 127/306 (41%), Gaps = 24/306 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ ++ D K VS S D + VWD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +++ GGLDN+ +++ ++ + +++ L H +S D
Sbjct: 106 ----------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAH-TGYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D + SPD + +G ++ +
Sbjct: 155 NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
GT + I ++ + P+G I +G++ S LFD+ Q + + E+ ++
Sbjct: 215 EGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICSIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
S+AFS +LL + +D NV++ E + + D++ + V + DG +AT +
Sbjct: 275 SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSW 332
Query: 420 DGSIRV 425
D +++
Sbjct: 333 DSFLKI 338
Score = 56.4 bits (130), Expect = 2e-07
Identities = 62/274 (22%), Positives = 107/274 (39%), Gaps = 12/274 (4%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 70 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 126
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 127 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 185
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
MS+A SPD SGA S L+DV +G T H + ++ F P + + + S
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 378 NDGYVNVYNIESAALQNKLDHK---CWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
+D ++++ + H+ C SV FS G+ + D + V + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICSITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
H + V + ADG + + S D + I+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/207 (19%), Positives = 88/207 (42%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G + + S D S +++
Sbjct: 228 DINAICFFPNGEAICTGSDDASCRLFD 254
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/115 (25%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF---TLSVAYSPDGKYI 63
+D+ + F P+G+ + +GS+ +F + + QE + + SVA+S G+ +
Sbjct: 227 SDINAICFFPNGEAICTGSDDASCRLFDLRA-DQELICFSHESIICSITSVAFSLSGRLL 285
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+G D N++D + + V L GH + L + D + TGS D +K+++
Sbjct: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BC002454-1|AAH02454.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 3 protein.
Length = 340
Score = 93.9 bits (223), Expect = 1e-18
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 115 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F I + S+D
Sbjct: 234 FFPNGEAICTGSDD 247
Score = 82.6 bits (195), Expect = 3e-15
Identities = 51/182 (28%), Positives = 86/182 (47%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V +G T GH I ++CF P+ + + TGSDD +L+D + A+ H S
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIIC 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ +G D VWD + H+++V + A+ + + S
Sbjct: 272 SITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 331
Query: 194 ED 195
D
Sbjct: 332 WD 333
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 110 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ I F P+G + TG ++ + + + + I S
Sbjct: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIICSITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D + + + + H V L + +A+ S D +
Sbjct: 276 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 69.7 bits (163), Expect = 2e-11
Identities = 56/251 (22%), Positives = 101/251 (40%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVC---GVQFNADGSKLVS 458
++CF P+G+ + T + D S R+ L + L F H I+C V F+ G L +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICSITSVAFSLSGRLLFA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 69.3 bits (162), Expect = 3e-11
Identities = 43/155 (27%), Positives = 73/155 (47%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D +L SPD ISG+ ++ V G Q ++ + P+G+ I +G+
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q + + E SI S+ FS +LL G DD + ++D + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICSITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G LSGH + V + + DG +GS D +++W+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 66.9 bits (156), Expect = 1e-10
Identities = 64/306 (20%), Positives = 127/306 (41%), Gaps = 24/306 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ ++ D K VS S D + VWD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +++ GGLDN+ +++ ++ + +++ L H +S D
Sbjct: 106 ----------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAH-TGYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D + SPD + +G ++ +
Sbjct: 155 NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
GT + I ++ + P+G I +G++ S LFD+ Q + + E+ ++
Sbjct: 215 EGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICSIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
S+AFS +LL + +D NV++ E + + D++ + V + DG +AT +
Sbjct: 275 SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSW 332
Query: 420 DGSIRV 425
D +++
Sbjct: 333 DSFLKI 338
Score = 56.4 bits (130), Expect = 2e-07
Identities = 62/274 (22%), Positives = 107/274 (39%), Gaps = 12/274 (4%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 70 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 126
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 127 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 185
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
MS+A SPD SGA S L+DV +G T H + ++ F P + + + S
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 378 NDGYVNVYNIESAALQNKLDHK---CWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
+D ++++ + H+ C SV FS G+ + D + V + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICSITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
H + V + ADG + + S D + I+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/207 (19%), Positives = 88/207 (42%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G + + S D S +++
Sbjct: 228 DINAICFFPNGEAICTGSDDASCRLFD 254
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/115 (25%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF---TLSVAYSPDGKYI 63
+D+ + F P+G+ + +GS+ +F + + QE + + SVA+S G+ +
Sbjct: 227 SDINAICFFPNGEAICTGSDDASCRLFDLRA-DQELICFSHESIICSITSVAFSLSGRLL 285
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+G D N++D + + V L GH + L + D + TGS D +K+++
Sbjct: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>BC000115-1|AAH00115.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 3 protein.
Length = 340
Score = 93.9 bits (223), Expect = 1e-18
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 115 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F I + S+D
Sbjct: 234 FFPNGEAICTGSDD 247
Score = 82.6 bits (195), Expect = 3e-15
Identities = 51/182 (28%), Positives = 86/182 (47%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V +G T GH I ++CF P+ + + TGSDD +L+D + A+ H S
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIIC 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ +G D VWD + H+++V + A+ + + S
Sbjct: 272 SITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 331
Query: 194 ED 195
D
Sbjct: 332 WD 333
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 110 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ I F P+G + TG ++ + + + + I S
Sbjct: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIICSITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D + + + + H V L + +A+ S D +
Sbjct: 276 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 69.7 bits (163), Expect = 2e-11
Identities = 56/251 (22%), Positives = 101/251 (40%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVC---GVQFNADGSKLVS 458
++CF P+G+ + T + D S R+ L + L F H I+C V F+ G L +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICSITSVAFSLSGRLLFA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 69.3 bits (162), Expect = 3e-11
Identities = 43/155 (27%), Positives = 73/155 (47%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D +L SPD ISG+ ++ V G Q ++ + P+G+ I +G+
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q + + E SI S+ FS +LL G DD + ++D + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICSITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G LSGH + V + + DG +GS D +++W+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 66.9 bits (156), Expect = 1e-10
Identities = 64/306 (20%), Positives = 127/306 (41%), Gaps = 24/306 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ ++ D K VS S D + VWD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +++ GGLDN+ +++ ++ + +++ L H +S D
Sbjct: 106 ----------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAH-TGYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D + SPD + +G ++ +
Sbjct: 155 NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
GT + I ++ + P+G I +G++ S LFD+ Q + + E+ ++
Sbjct: 215 EGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICSIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
S+AFS +LL + +D NV++ E + + D++ + V + DG +AT +
Sbjct: 275 SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSW 332
Query: 420 DGSIRV 425
D +++
Sbjct: 333 DSFLKI 338
Score = 56.4 bits (130), Expect = 2e-07
Identities = 62/274 (22%), Positives = 107/274 (39%), Gaps = 12/274 (4%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 70 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 126
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 127 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 185
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
MS+A SPD SGA S L+DV +G T H + ++ F P + + + S
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 378 NDGYVNVYNIESAALQNKLDHK---CWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
+D ++++ + H+ C SV FS G+ + D + V + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICSITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
H + V + ADG + + S D + I+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/207 (19%), Positives = 88/207 (42%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G + + S D S +++
Sbjct: 228 DINAICFFPNGEAICTGSDDASCRLFD 254
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/115 (25%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF---TLSVAYSPDGKYI 63
+D+ + F P+G+ + +GS+ +F + + QE + + SVA+S G+ +
Sbjct: 227 SDINAICFFPNGEAICTGSDDASCRLFDLRA-DQELICFSHESIICSITSVAFSLSGRLL 285
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+G D N++D + + V L GH + L + D + TGS D +K+++
Sbjct: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>AY631872-1|AAT38116.1| 340|Homo sapiens guanine nucleotide binding
protein (G protein), beta polypeptide 3 protein.
Length = 340
Score = 93.9 bits (223), Expect = 1e-18
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 115 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F I + S+D
Sbjct: 234 FFPNGEAICTGSDD 247
Score = 83.0 bits (196), Expect = 2e-15
Identities = 51/182 (28%), Positives = 86/182 (47%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V +G T GH I ++CF P+ + + TGSDD +L+D + A+ H S
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIIC 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ +G D VWD + H+++V + A+ + + S
Sbjct: 272 GITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 331
Query: 194 ED 195
D
Sbjct: 332 WD 333
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 110 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ I F P+G + TG ++ + + + + I S
Sbjct: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D + + + + H V L + +A+ S D +
Sbjct: 276 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 72.1 bits (169), Expect = 4e-12
Identities = 57/251 (22%), Positives = 102/251 (40%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G+ + T + D S R+ L + L F H I+CG V F+ G L +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 67.7 bits (158), Expect = 8e-11
Identities = 42/155 (27%), Positives = 72/155 (46%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D +L SPD ISG+ ++ V G Q ++ + P+G+ I +G+
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q + + E I S+ FS +LL G DD + ++D + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G LSGH + V + + DG +GS D +++W+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 66.5 bits (155), Expect = 2e-10
Identities = 64/306 (20%), Positives = 126/306 (41%), Gaps = 24/306 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ ++ D K VS S D + VWD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +++ GGLDN+ +++ ++ + +++ L H +S D
Sbjct: 106 ----------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAH-TGYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D + SPD + +G ++ +
Sbjct: 155 NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
GT + I ++ + P+G I +G++ S LFD+ Q + + E+ +
Sbjct: 215 EGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
S+AFS +LL + +D NV++ E + + D++ + V + DG +AT +
Sbjct: 275 SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSW 332
Query: 420 DGSIRV 425
D +++
Sbjct: 333 DSFLKI 338
Score = 56.8 bits (131), Expect = 2e-07
Identities = 62/274 (22%), Positives = 107/274 (39%), Gaps = 12/274 (4%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 70 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 126
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 127 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 185
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
MS+A SPD SGA S L+DV +G T H + ++ F P + + + S
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 378 NDGYVNVYNIESAALQNKLDHK---CWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
+D ++++ + H+ C SV FS G+ + D + V + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
H + V + ADG + + S D + I+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/207 (19%), Positives = 88/207 (42%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G + + S D S +++
Sbjct: 228 DINAICFFPNGEAICTGSDDASCRLFD 254
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/115 (25%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF---TLSVAYSPDGKYI 63
+D+ + F P+G+ + +GS+ +F + + QE + + SVA+S G+ +
Sbjct: 227 SDINAICFFPNGEAICTGSDDASCRLFDLRA-DQELICFSHESIICGITSVAFSLSGRLL 285
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+G D N++D + + V L GH + L + D + TGS D +K+++
Sbjct: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>AF501884-1|AAM15920.1| 340|Homo sapiens guanine nucleotide binding
protein beta 3 protein.
Length = 340
Score = 93.9 bits (223), Expect = 1e-18
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 55 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 114
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 115 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 173
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 174 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 233
Query: 182 FNAESNKIISVSED 195
F I + S+D
Sbjct: 234 FFPNGEAICTGSDD 247
Score = 83.0 bits (196), Expect = 2e-15
Identities = 51/182 (28%), Positives = 86/182 (47%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V +G T GH I ++CF P+ + + TGSDD +L+D + A+ H S
Sbjct: 213 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIIC 271
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ +G D VWD + H+++V + A+ + + S
Sbjct: 272 GITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 331
Query: 194 ED 195
D
Sbjct: 332 WD 333
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 110 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 158
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 159 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 216
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ I F P+G + TG ++ + + + + I S
Sbjct: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIICGITS 275
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D + + + + H V L + +A+ S D +
Sbjct: 276 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 335
Query: 382 VNVYN 386
+ ++N
Sbjct: 336 LKIWN 340
Score = 72.1 bits (169), Expect = 4e-12
Identities = 57/251 (22%), Positives = 102/251 (40%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 110 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 168
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 169 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 228
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G+ + T + D S R+ L + L F H I+CG V F+ G L +
Sbjct: 229 INAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFA 287
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 288 GYDDFNCNVWD 298
Score = 67.7 bits (158), Expect = 8e-11
Identities = 42/155 (27%), Positives = 72/155 (46%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D +L SPD ISG+ ++ V G Q ++ + P+G+ I +G+
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q + + E I S+ FS +LL G DD + ++D + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G LSGH + V + + DG +GS D +++W+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 66.5 bits (155), Expect = 2e-10
Identities = 64/306 (20%), Positives = 126/306 (41%), Gaps = 24/306 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ ++ D K VS S D + VWD + H + V +
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY---- 105
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +++ GGLDN+ +++ ++ + +++ L H +S D
Sbjct: 106 ----------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAH-TGYLSCCRFLDD 154
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D + SPD + +G ++ +
Sbjct: 155 NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 214
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
GT + I ++ + P+G I +G++ S LFD+ Q + + E+ +
Sbjct: 215 EGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGIT 274
Query: 363 SLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
S+AFS +LL + +D NV++ E + + D++ + V + DG +AT +
Sbjct: 275 SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSW 332
Query: 420 DGSIRV 425
D +++
Sbjct: 333 DSFLKI 338
Score = 56.8 bits (131), Expect = 2e-07
Identities = 62/274 (22%), Positives = 107/274 (39%), Gaps = 12/274 (4%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 70 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 126
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 127 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 185
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
MS+A SPD SGA S L+DV +G T H + ++ F P + + + S
Sbjct: 186 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 245
Query: 378 NDGYVNVYNIESAALQNKLDHK---CWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
+D ++++ + H+ C SV FS G+ + D + V + +
Sbjct: 246 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 305
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
H + V + ADG + + S D + I+
Sbjct: 306 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/207 (19%), Positives = 88/207 (42%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 167
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G + + S D S +++
Sbjct: 228 DINAICFFPNGEAICTGSDDASCRLFD 254
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/115 (25%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF---TLSVAYSPDGKYI 63
+D+ + F P+G+ + +GS+ +F + + QE + + SVA+S G+ +
Sbjct: 227 SDINAICFFPNGEAICTGSDDASCRLFDLRA-DQELICFSHESIICGITSVAFSLSGRLL 285
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+G D N++D + + V L GH + L + D + TGS D +K+++
Sbjct: 286 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 44 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 103
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 162
Query: 462 DKSINIYE 469
D + +++
Sbjct: 163 DTTCALWD 170
>AB209669-1|BAD92906.1| 1903|Homo sapiens Telomerase protein component
1 variant protein.
Length = 1903
Score = 93.9 bits (223), Expect = 1e-18
Identities = 115/475 (24%), Positives = 198/475 (41%), Gaps = 43/475 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQ-VLDTRGKFTLSVAYSPDGKYIASGALDGII 72
FS +G+ G+ G + + + + ++E+ V+ + + S D ++ A DG++
Sbjct: 1026 FSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT--AFDGLL 1083
Query: 73 NIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA 132
++D+ G V + H I C SPD QLL T G +KL+D V LA + +
Sbjct: 1084 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCQLLATVCLGGCLKLWDTVRGQLAFQHT-YP 1142
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+ VAF P+G+ +GS ++ + +D ++ + + FN
Sbjct: 1143 KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGG----- 1197
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
+ G LD++V++W++ L H V + G +
Sbjct: 1198 ---------VVAVGRLDSMVELWAWREG--ARLAAFPAHHGFVAAALFLHAGCQLLTAGE 1246
Query: 253 XXXXXXXXXXXGQKIREIQTDS-SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
G+ + + S S + SPDG +VA G + +Y I +G+
Sbjct: 1247 DGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQ 1306
Query: 312 LDTRGKFIMSVAW-SPDGRYIASGAEGGSVYLFDVSQGKM--LHTIEAHAQAVRSLAFSP 368
+ ++AW SP + + SGAE GS+ + + + + L + + V LA S
Sbjct: 1307 GQALDVAVSALAWLSP--KVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATS- 1363
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWA--------VSVC-FSPDGQRMATSA 418
+LLASAS D V ++ + +K D C VS C FS DG +AT
Sbjct: 1364 -QELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGG 1422
Query: 419 ADGSIRV--VLLEEFRVL-HTFEE-HTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
D S+ V + VL H+F H V G + D + L+S S D S+ +++
Sbjct: 1423 RDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKD-NLLISCSSDGSVGLWD 1476
Score = 82.6 bits (195), Expect = 3e-15
Identities = 108/480 (22%), Positives = 192/480 (40%), Gaps = 41/480 (8%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P+G+ + +GS AG I F V+ K + L G ++A++ G +A G LD ++
Sbjct: 1150 FHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVE 1209
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA- 132
++ +G + H + + F LLT +DG ++++ G L +
Sbjct: 1210 LWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSL 1269
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
S LSVA SPDG R G +R++ + S Q G + A ++V
Sbjct: 1270 SPALSVALSPDGDRVAVGYRADGIRIYKISS----------GSQ--GAQGQALD---VAV 1314
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
S S +V+G D ++ W+ + L+ L L + PV+ +A S + A
Sbjct: 1315 SALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDF 1374
Query: 253 XXXXX-XXXXXXGQKIR------EIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIIN 305
K E++ + FS DG +ATGG + + +
Sbjct: 1375 TVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRT 1434
Query: 306 GTVDKVLDT----RGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
++ + ++ AW+ D I+ ++G SV L+D G+ L H AV
Sbjct: 1435 PKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDG-SVGLWDPESGQRLGQFLGHQSAV 1493
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMA------ 415
++A + + S S DG + V++ + L + H +S C + R A
Sbjct: 1494 SAVA--AVEEHVVSVSRDGTLKVWDHQGVELTSIPAHS-GPISHCAAAMEPRAAGQPGSE 1550
Query: 416 ----TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYECP 471
T DG+ R+ HT H+ V + +++ S+D S+ +++ P
Sbjct: 1551 LLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVP 1610
Score = 74.1 bits (174), Expect = 1e-12
Identities = 74/291 (25%), Positives = 120/291 (41%), Gaps = 20/291 (6%)
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
+VAFS +G+R G+A+ TV + DL T++E V G +S
Sbjct: 1023 AVAFSTNGQRAAVGTANGTVYLLDL------RTWQEEKSVVSGCD---------GISACL 1067
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
S D + D L+++W ++ +L T + H+ + +SPD + +A
Sbjct: 1068 FLSDDTLFLTAFDGLLELWDLQHG-CRVLQT-KAHQYQITGCCLSPDCQLLATVCLGGCL 1125
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
GQ + T + + F P+G +ATG G ++ + + V K L G
Sbjct: 1126 KLWDTVRGQLAFQ-HTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPG 1184
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
I ++A++ G +A G V L+ +G L AH V + F L +A
Sbjct: 1185 ASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTA 1244
Query: 377 SNDGYVNVYNIESAALQNKLDHKCW--AVSVCFSPDGQRMATSAADGSIRV 425
DG V V++ + L A+SV SPDG R+A IR+
Sbjct: 1245 GEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRI 1295
Score = 62.5 bits (145), Expect = 3e-09
Identities = 62/251 (24%), Positives = 106/251 (42%), Gaps = 15/251 (5%)
Query: 55 AYSPDGKYIASGALDGIINIFDVAQGK---LVHTLEG-HAMSIRSLCFSPDSQLLLTGSD 110
++S DG +A+G D + +DV K L+H+ H + ++ D+ LL++ S
Sbjct: 1410 SFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN-LLISCSS 1468
Query: 111 DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF 170
DG + L+D G GH S V +VA + VS S D T++VWD ++ +
Sbjct: 1469 DGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRDGTLKVWDHQGVELT-SI 1525
Query: 171 KEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
H+ + E + + S+ +VT GLD ++W + HTL G
Sbjct: 1526 PAHSGPISHCAAAMEPR-----AAGQPGSELLVVTVGLDGATRLW--HPLLVCQTHTLLG 1578
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H PV + AVS + I S+ + + ++PDGS
Sbjct: 1579 HSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAV 1638
Query: 291 TGGHTGKVTVY 301
+G G++ ++
Sbjct: 1639 SGNQAGELILW 1649
Score = 50.0 bits (114), Expect = 2e-05
Identities = 63/284 (22%), Positives = 103/284 (36%), Gaps = 35/284 (12%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSG----HASWVLSVAFS 141
L GH + FS D L TG D + +DV + H WV A++
Sbjct: 1399 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT 1458
Query: 142 PDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKD 201
D +S S+D +V +WD +S Q F H V V A ++SVS D
Sbjct: 1459 KDNL-LISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA--AVEEHVVSVSRD------ 1509
Query: 202 YIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD----GETIAXXXXXXXXX 257
+KVW ++ +L ++ H P+ A + + G+ +
Sbjct: 1510 --------GTLKVWDHQGVELT---SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGL 1558
Query: 258 XXXXXXGQKIREIQTD-----SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVL 312
+ QT S + S + T G V ++ + D +
Sbjct: 1559 DGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCI 1618
Query: 313 DTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ +VAW+PDG SG + G + L+ + K + T +A
Sbjct: 1619 PRSSAAVTAVAWAPDGSMAVSGNQAGELILW--QEAKAVATAQA 1660
Score = 48.8 bits (111), Expect = 4e-05
Identities = 56/204 (27%), Positives = 89/204 (43%), Gaps = 17/204 (8%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAY-SPDGKYIA 64
L+ ++ SPDG V G A I I+ + SG Q ++A+ SP K +
Sbjct: 1269 LSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLV 1326
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD---VVH 121
SGA DG + + + + L L + +LL + S+D ++L+ +
Sbjct: 1327 SGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTR 1386
Query: 122 ANLA-----GT-LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ---HTFKE 172
+ A GT L GH V +FS DG +G DR++ WD+ + + H+F
Sbjct: 1387 PHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPA 1446
Query: 173 -HNDQVWGVKFNAESNKIISVSED 195
H D V G + + N +IS S D
Sbjct: 1447 CHRDWVTGCAW-TKDNLLISCSSD 1469
Score = 42.7 bits (96), Expect = 0.003
Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 5/127 (3%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAV-SVCFSPD 410
HT+ H+ VR+ A S + L+ +AS DG V ++ + A + AV +V ++PD
Sbjct: 1574 HTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPD 1633
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
G MA S ++L +E + + T + HI G + +S D+ I+ ++
Sbjct: 1634 GS-MAVSGNQAG-ELILWQEAKAVATAQAPGHI--GALIWSSAHTFFVLSADEKISEWQV 1689
Query: 471 PIPPKSA 477
+ SA
Sbjct: 1690 KLRKGSA 1696
>AB209283-1|BAD92520.1| 327|Homo sapiens guanine nucleotide-binding
protein, beta-3 subunit variant protein.
Length = 327
Score = 93.9 bits (223), Expect = 1e-18
Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 5/194 (2%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L ++ + ++ D K ++S S GK++++ + + + R + ++ AY+P G ++A
Sbjct: 42 LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVAC 101
Query: 66 GALDGIINIFDVA--QG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
G LD + +I+++ +G K+ L H + S C D ++T S D L+D+
Sbjct: 102 GGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVTSSGDTTCALWDIET 160
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
GH +S+A SPD F+SG+ D + ++WD+ C+ TF H + +
Sbjct: 161 GQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAIC 220
Query: 182 FNAESNKIISVSED 195
F I + S+D
Sbjct: 221 FFPNGEAICTGSDD 234
Score = 83.0 bits (196), Expect = 2e-15
Identities = 51/182 (28%), Positives = 86/182 (47%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D ++++ S ++ +E+G+Q+ V +S+A SPD SGA D ++D
Sbjct: 140 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 199
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS--- 133
V +G T GH I ++CF P+ + + TGSDD +L+D + A+ H S
Sbjct: 200 VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIIC 258
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ SVAFS G+ +G D VWD + H+++V + A+ + + S
Sbjct: 259 GITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGS 318
Query: 194 ED 195
D
Sbjct: 319 WD 320
Score = 79.4 bits (187), Expect = 3e-14
Identities = 68/305 (22%), Positives = 129/305 (42%), Gaps = 17/305 (5%)
Query: 85 TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDG 144
TL GH I ++ ++ DS+LL++ S DG + ++D N + +SWV++ A++P G
Sbjct: 37 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 96
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
G D +++L S +E N +V + +A + + S + + IV
Sbjct: 97 NFVACGGLDNMCSIYNLKS-------REGNVKV-SRELSAHTGYL---SCCRFLDDNNIV 145
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
T D +W E + + + GH +S+AVSPD G
Sbjct: 146 TSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREG 203
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF---IMS 321
+ SD+ I F P+G + TG ++ + + + + I S
Sbjct: 204 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD-LRADQELICFSHESIICGITS 262
Query: 322 VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
VA+S GR + +G + + ++D + + + + H V L + +A+ S D +
Sbjct: 263 VAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSF 322
Query: 382 VNVYN 386
+ ++N
Sbjct: 323 LKIWN 327
Score = 72.1 bits (169), Expect = 4e-12
Identities = 57/251 (22%), Positives = 102/251 (40%), Gaps = 10/251 (3%)
Query: 227 TLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDG 286
TL GH + ++ + D + + K+ I SS + ++P G
Sbjct: 37 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 96
Query: 287 SQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
+ VA GG ++Y + N V + L ++ + D + S + + L
Sbjct: 97 NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD-TTCAL 155
Query: 343 FDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-ESAALQNKLDHKCW 401
+D+ G+ H SLA SP L S + D ++++ E Q H+
Sbjct: 156 WDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESD 215
Query: 402 AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG---VQFNADGSKLVS 458
++CF P+G+ + T + D S R+ L + L F H I+CG V F+ G L +
Sbjct: 216 INAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLFA 274
Query: 459 VSKDKSINIYE 469
D + N+++
Sbjct: 275 GYDDFNCNVWD 285
Score = 67.7 bits (158), Expect = 8e-11
Identities = 42/155 (27%), Positives = 72/155 (46%), Gaps = 2/155 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D +L SPD ISG+ ++ V G Q ++ + P+G+ I +G+
Sbjct: 173 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 232
Query: 68 LDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
D +FD+ Q + + E I S+ FS +LL G DD + ++D + +
Sbjct: 233 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 292
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
G LSGH + V + + DG +GS D +++W+
Sbjct: 293 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 327
Score = 66.5 bits (155), Expect = 2e-10
Identities = 64/306 (20%), Positives = 126/306 (41%), Gaps = 24/306 (7%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
TL GH + + ++ ++ D K VS S D + VWD + H + V +
Sbjct: 37 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY---- 92
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDG 244
PS +++ GGLDN+ +++ ++ + +++ L H +S D
Sbjct: 93 ----------APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAH-TGYLSCCRFLDD 141
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII 304
I GQ+ + D + SPD + +G ++ +
Sbjct: 142 NNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVR 201
Query: 305 NGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVR 362
GT + I ++ + P+G I +G++ S LFD+ Q + + E+ +
Sbjct: 202 EGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGIT 261
Query: 363 SLAFSPKTKLLASASNDGYVNVYN---IESAALQNKLDHKCWAVSVCFSPDGQRMATSAA 419
S+AFS +LL + +D NV++ E + + D++ + V + DG +AT +
Sbjct: 262 SVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGV--TADGMAVATGSW 319
Query: 420 DGSIRV 425
D +++
Sbjct: 320 DSFLKI 325
Score = 56.8 bits (131), Expect = 2e-07
Identities = 62/274 (22%), Positives = 107/274 (39%), Gaps = 12/274 (4%)
Query: 203 IVTGGLDNLVKVW-SYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+V+ D + VW SY NK+ H + V++ A +P G +A
Sbjct: 57 LVSASQDGKLIVWDSYTTNKV---HAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNL 113
Query: 262 XXGQ---KI-REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ K+ RE+ + + F D + V + G T ++ I G V
Sbjct: 114 KSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDT-TCALWDIETGQQKTVFVGHTG 172
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
MS+A SPD SGA S L+DV +G T H + ++ F P + + + S
Sbjct: 173 DCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGS 232
Query: 378 NDGYVNVYNIESAALQNKLDHK---CWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
+D ++++ + H+ C SV FS G+ + D + V + +
Sbjct: 233 DDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERV 292
Query: 435 HTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
H + V + ADG + + S D + I+
Sbjct: 293 GILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 326
Score = 51.6 bits (118), Expect = 6e-06
Identities = 41/207 (19%), Positives = 88/207 (42%), Gaps = 6/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R ++ + ++ + ++ D + + GK+ V+ + R ++M+ A++P
Sbjct: 36 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 95
Query: 328 GRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
G ++A G S+Y +G K+ + AH + F ++ S S D
Sbjct: 96 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS-SGDTTCA 154
Query: 384 VYNIESAALQNK-LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+++IE+ + + H +S+ SPD + A D S ++ + E TF H
Sbjct: 155 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 214
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIYE 469
+ + F +G + + S D S +++
Sbjct: 215 DINAICFFPNGEAICTGSDDASCRLFD 241
Score = 44.8 bits (101), Expect = 7e-04
Identities = 29/115 (25%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF---TLSVAYSPDGKYI 63
+D+ + F P+G+ + +GS+ +F + + QE + + SVA+S G+ +
Sbjct: 214 SDINAICFFPNGEAICTGSDDASCRLFDLRA-DQELICFSHESIICGITSVAFSLSGRLL 272
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+G D N++D + + V L GH + L + D + TGS D +K+++
Sbjct: 273 FAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 327
Score = 35.9 bits (79), Expect = 0.32
Identities = 26/128 (20%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 347 QGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSV 405
Q + T+ H + ++ ++ +KLL SAS DG + V++ + + + W ++
Sbjct: 31 QMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTC 90
Query: 406 CFSPDGQRMATSAADGSIRVVLLE----EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSK 461
++P G +A D + L+ +V HT + +F D + +V+ S
Sbjct: 91 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSG 149
Query: 462 DKSINIYE 469
D + +++
Sbjct: 150 DTTCALWD 157
>Y12781-1|CAA73319.1| 577|Homo sapiens transducin (beta) like 1
protein protein.
Length = 577
Score = 93.5 bits (222), Expect = 1e-18
Identities = 85/368 (23%), Positives = 152/368 (41%), Gaps = 41/368 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL----------SGH---- 131
L GH + ++P S LL +GS D +++++ + G+ GH
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ +G +GS D R+W D T +H ++ +K+N + N
Sbjct: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKGN---- 342
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
YI++ G+D +W E H P + V + T A
Sbjct: 343 ----------YILSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCS 389
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
+ ++ Q ++++ I + P G +A+ + ++ +
Sbjct: 390 TDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 449
Query: 312 LDTRGKFIMSVAWSPDGR---------YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+D+ +G HT+ H + V
Sbjct: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP K LAS S D V+++N +S L + VC++ G ++ SA+DGS
Sbjct: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGS 569
Query: 423 IRVVLLEE 430
+ V+ L +
Sbjct: 570 VCVLDLRK 577
Score = 88.6 bits (210), Expect = 4e-17
Identities = 80/363 (22%), Positives = 158/363 (43%), Gaps = 21/363 (5%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ---CQHTFKEHNDQ 176
+ ++ A L GH S V A++P SGS D T R+W+L+ H +
Sbjct: 220 IPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIR 279
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVV 236
G + SNK ++ S D + + TG D ++W+ + N L TL H+ P+
Sbjct: 280 EGG--HDVPSNKDVT-SLDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQHKGPIF 333
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
++ + G I G+ ++ S+ + + + + A+
Sbjct: 334 ALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDM 392
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ V + K + ++ W P G +AS ++ ++ ++ + Q +H ++A
Sbjct: 393 CIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQA 452
Query: 357 HAQAVRSLAFSP---------KTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVC 406
H + + ++ +SP +LASAS D V +++IE + L H+ SV
Sbjct: 453 HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVA 512
Query: 407 FSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSIN 466
FSPDG+ +A+ + D + + + ++H++ T + V +NA G K+ + + D S+
Sbjct: 513 FSPDGKYLASGSFDKCVHIWNTQSGNLVHSY-RGTGGIFEVCWNARGDKVGASASDGSVC 571
Query: 467 IYE 469
+ +
Sbjct: 572 VLD 574
Score = 83.0 bits (196), Expect = 2e-15
Identities = 64/293 (21%), Positives = 121/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ +G + +GS G I+ E G L ++ ++ G YI S
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 348
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + T
Sbjct: 349 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 407
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H + HN +++ +K++
Sbjct: 408 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP--- 464
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ S + + D+ V++W E HTL H+ PV SVA SPDG+ +
Sbjct: 465 --TGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYL 520
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + + + ++++ ++ G +V G V V
Sbjct: 521 ASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCWNARGDKVGASASDGSVCV 572
Score = 54.0 bits (124), Expect = 1e-06
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ +E G L + SVA+SPDGKY+ASG+ D ++I++ G L
Sbjct: 480 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 539
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ G I +C++ + + DG + + D+
Sbjct: 540 VHSYRGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 575
>BC052304-1|AAH52304.1| 577|Homo sapiens transducin (beta)-like
1X-linked protein.
Length = 577
Score = 93.5 bits (222), Expect = 1e-18
Identities = 85/368 (23%), Positives = 152/368 (41%), Gaps = 41/368 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL----------SGH---- 131
L GH + ++P S LL +GS D +++++ + G+ GH
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ +G +GS D R+W D T +H ++ +K+N + N
Sbjct: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKGN---- 342
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
YI++ G+D +W E H P + V + T A
Sbjct: 343 ----------YILSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCS 389
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
+ ++ Q ++++ I + P G +A+ + ++ +
Sbjct: 390 TDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 449
Query: 312 LDTRGKFIMSVAWSPDGR---------YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+D+ +G HT+ H + V
Sbjct: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP K LAS S D V+++N +S L + VC++ G ++ SA+DGS
Sbjct: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGS 569
Query: 423 IRVVLLEE 430
+ V+ L +
Sbjct: 570 VCVLDLRK 577
Score = 88.6 bits (210), Expect = 4e-17
Identities = 80/363 (22%), Positives = 158/363 (43%), Gaps = 21/363 (5%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ---CQHTFKEHNDQ 176
+ ++ A L GH S V A++P SGS D T R+W+L+ H +
Sbjct: 220 IPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIR 279
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVV 236
G + SNK ++ S D + + TG D ++W+ + N L TL H+ P+
Sbjct: 280 EGG--HDVPSNKDVT-SLDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQHKGPIF 333
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
++ + G I G+ ++ S+ + + + + A+
Sbjct: 334 ALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDM 392
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ V + K + ++ W P G +AS ++ ++ ++ + Q +H ++A
Sbjct: 393 CIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQA 452
Query: 357 HAQAVRSLAFSP---------KTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVC 406
H + + ++ +SP +LASAS D V +++IE + L H+ SV
Sbjct: 453 HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVA 512
Query: 407 FSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSIN 466
FSPDG+ +A+ + D + + + ++H++ T + V +NA G K+ + + D S+
Sbjct: 513 FSPDGKYLASGSFDKCVHIWNTQSGNLVHSY-RGTGGIFEVCWNARGDKVGASASDGSVC 571
Query: 467 IYE 469
+ +
Sbjct: 572 VLD 574
Score = 83.0 bits (196), Expect = 2e-15
Identities = 64/293 (21%), Positives = 121/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ +G + +GS G I+ E G L ++ ++ G YI S
Sbjct: 290 DVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 348
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + T
Sbjct: 349 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 407
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H + HN +++ +K++
Sbjct: 408 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP--- 464
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ S + + D+ V++W E HTL H+ PV SVA SPDG+ +
Sbjct: 465 --TGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYL 520
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + + + ++++ ++ G +V G V V
Sbjct: 521 ASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCWNARGDKVGASASDGSVCV 572
Score = 54.0 bits (124), Expect = 1e-06
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ +E G L + SVA+SPDGKY+ASG+ D ++I++ G L
Sbjct: 480 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 539
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ G I +C++ + + DG + + D+
Sbjct: 540 VHSYRGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 575
>BC032708-1|AAH32708.1| 526|Homo sapiens TBL1X protein protein.
Length = 526
Score = 93.5 bits (222), Expect = 1e-18
Identities = 85/368 (23%), Positives = 152/368 (41%), Gaps = 41/368 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL----------SGH---- 131
L GH + ++P S LL +GS D +++++ + G+ GH
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ +G +GS D R+W D T +H ++ +K+N + N
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKGN---- 291
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
YI++ G+D +W E H P + V + T A
Sbjct: 292 ----------YILSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCS 338
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
+ ++ Q ++++ I + P G +A+ + ++ +
Sbjct: 339 TDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 398
Query: 312 LDTRGKFIMSVAWSPDGR---------YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+D+ +G HT+ H + V
Sbjct: 399 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 458
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP K LAS S D V+++N +S L + VC++ G ++ SA+DGS
Sbjct: 459 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGS 518
Query: 423 IRVVLLEE 430
+ V+ L +
Sbjct: 519 VCVLDLRK 526
Score = 88.6 bits (210), Expect = 4e-17
Identities = 80/363 (22%), Positives = 158/363 (43%), Gaps = 21/363 (5%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ---CQHTFKEHNDQ 176
+ ++ A L GH S V A++P SGS D T R+W+L+ H +
Sbjct: 169 IPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIR 228
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVV 236
G + SNK ++ S D + + TG D ++W+ + N L TL H+ P+
Sbjct: 229 EGG--HDVPSNKDVT-SLDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQHKGPIF 282
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
++ + G I G+ ++ S+ + + + + A+
Sbjct: 283 ALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDM 341
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ V + K + ++ W P G +AS ++ ++ ++ + Q +H ++A
Sbjct: 342 CIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQA 401
Query: 357 HAQAVRSLAFSP---------KTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVC 406
H + + ++ +SP +LASAS D V +++IE + L H+ SV
Sbjct: 402 HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVA 461
Query: 407 FSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSIN 466
FSPDG+ +A+ + D + + + ++H++ T + V +NA G K+ + + D S+
Sbjct: 462 FSPDGKYLASGSFDKCVHIWNTQSGNLVHSY-RGTGGIFEVCWNARGDKVGASASDGSVC 520
Query: 467 IYE 469
+ +
Sbjct: 521 VLD 523
Score = 83.0 bits (196), Expect = 2e-15
Identities = 64/293 (21%), Positives = 121/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ +G + +GS G I+ E G L ++ ++ G YI S
Sbjct: 239 DVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 297
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + T
Sbjct: 298 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 356
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H + HN +++ +K++
Sbjct: 357 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP--- 413
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ S + + D+ V++W E HTL H+ PV SVA SPDG+ +
Sbjct: 414 --TGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYL 469
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + + + ++++ ++ G +V G V V
Sbjct: 470 ASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCWNARGDKVGASASDGSVCV 521
Score = 54.0 bits (124), Expect = 1e-06
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ +E G L + SVA+SPDGKY+ASG+ D ++I++ G L
Sbjct: 429 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 488
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ G I +C++ + + DG + + D+
Sbjct: 489 VHSYRGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 524
>AF490390-1|AAM97147.1| 631|Homo sapiens sperm-associated WD repeat
protein protein.
Length = 631
Score = 93.5 bits (222), Expect = 1e-18
Identities = 65/306 (21%), Positives = 120/306 (39%), Gaps = 17/306 (5%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
KL + H + + + P +L++ +D K+ + N+ T GH W+ F
Sbjct: 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCF 402
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
P G + + S D TV++WDL + C TF+ H+ VW +++ N
Sbjct: 403 HPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGN------------- 449
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
++ + LD K+W + + TL GH V S+ P T+
Sbjct: 450 -FVASSSLDKTSKIWDVNSERCRC--TLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G + + + +F P G +A+ G ++ +D
Sbjct: 507 ARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGN 566
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDG 380
V + GR +A + G ++L D+ G+ +H + H ++ FS ++L S +DG
Sbjct: 567 EVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDG 625
Query: 381 YVNVYN 386
V ++
Sbjct: 626 TVRTWS 631
Score = 81.4 bits (192), Expect = 6e-15
Identities = 67/287 (23%), Positives = 113/287 (39%), Gaps = 17/287 (5%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V+ P + S D + + + + ++ T GH + CF P L T S D
Sbjct: 358 VSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTT 417
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL+D+ + T GH+ V S + G S S D+T ++WD++S +C+ T H
Sbjct: 418 VKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGH 477
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
D V ++F SN +++ S DK + +W E +L GH
Sbjct: 478 TDSVNSIEFFPFSNTLLTSSADK--------------TLSIWDARTGICE--QSLYGHMH 521
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
+ P G IA I I S ++ F G +A
Sbjct: 522 SINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQAS 581
Query: 294 HTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSV 340
G + + + +G + K++ + +V +S DG + SG G+V
Sbjct: 582 GNGVIHLLDLKSGEIHKLMGHENE-AHTVVFSHDGEILFSGGSDGTV 627
Score = 64.1 bits (149), Expect = 1e-09
Identities = 44/158 (27%), Positives = 68/158 (43%), Gaps = 3/158 (1%)
Query: 5 GLTDVWTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
G TD W D F P G + + S + ++ + +G + + S + G +
Sbjct: 392 GHTD-WLSDCCFHPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNF 450
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+AS +LD I+DV + TL GH S+ S+ F P S LLT S D + ++D
Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+L GH + F P G S A ++WD
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Score = 61.7 bits (143), Expect = 6e-09
Identities = 49/227 (21%), Positives = 92/227 (40%), Gaps = 2/227 (0%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
PS D + T D VK+W + + T EGH V S G +A
Sbjct: 404 PSGDKLATSSGDTTVKLWDLCTG--DCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSK 461
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ + + + I F P + + T ++++ G ++ L
Sbjct: 462 IWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMH 521
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
I + P G IAS G L+D + + +I+ + F ++LA AS
Sbjct: 522 SINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQAS 581
Query: 378 NDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIR 424
+G +++ +++S + + H+ A +V FS DG+ + + +DG++R
Sbjct: 582 GNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVR 628
Score = 54.0 bits (124), Expect = 1e-06
Identities = 36/154 (23%), Positives = 68/154 (44%), Gaps = 4/154 (2%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVY 341
F P G ++AT V ++ + G + + + S W G ++AS + +
Sbjct: 402 FHPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSK 461
Query: 342 LFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKC 400
++DV+ + T+ H +V S+ F P + L ++S D +++++ + + L H
Sbjct: 462 IWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMH 521
Query: 401 WAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
F P G +A+ A G V L +FR L
Sbjct: 522 SINDAIFDPRGHMIASCDACG---VTKLWDFRKL 552
Score = 52.0 bits (119), Expect = 4e-06
Identities = 31/122 (25%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCF 407
K+ + H V ++ P +L S D V + L H W CF
Sbjct: 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCF 402
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
P G ++ATS+ D ++++ L + TFE H+ V +++ G+ + S S DK+ I
Sbjct: 403 HPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKI 462
Query: 468 YE 469
++
Sbjct: 463 WD 464
Score = 49.2 bits (112), Expect = 3e-05
Identities = 40/156 (25%), Positives = 69/156 (44%), Gaps = 2/156 (1%)
Query: 5 GLTD-VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI 63
G TD V +++F P +++ S + I+ +G EQ L + P G I
Sbjct: 476 GHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI 535
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN 123
AS G+ ++D + + +++ + F ++L S +G + L D+
Sbjct: 536 ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE 595
Query: 124 LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ L GH + +V FS DG+ SG +D TVR W
Sbjct: 596 IH-KLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 45.2 bits (102), Expect = 5e-04
Identities = 43/194 (22%), Positives = 72/194 (37%), Gaps = 1/194 (0%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
FE VW+ + G V S S I+ V S + L S+ + P
Sbjct: 432 FEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSN 491
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
+ + + D ++I+D G +L GH SI F P ++ + G KL+D
Sbjct: 492 TLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
++ S V F G+ S + + + DL S + H H ++ V
Sbjct: 552 LLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVV 610
Query: 182 FNAESNKIISVSED 195
F+ + + S D
Sbjct: 611 FSHDGEILFSGGSD 624
Score = 41.9 bits (94), Expect = 0.005
Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 1/142 (0%)
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
++ + P G +A+ + +V L+D+ G + T E H++AV S + +AS+S
Sbjct: 396 WLSDCCFHPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSS 455
Query: 378 NDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D ++++ S + L H S+ F P + TS+AD ++ + +
Sbjct: 456 LDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQS 515
Query: 437 FEEHTHIVCGVQFNADGSKLVS 458
H H + F+ G + S
Sbjct: 516 LYGHMHSINDAIFDPRGHMIAS 537
Score = 34.3 bits (75), Expect = 0.97
Identities = 32/152 (21%), Positives = 66/152 (43%), Gaps = 1/152 (0%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V+ P + S E + + + +L T H + F P LA++S
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMATSAADGSIRVVLLEEFRVLHTF 437
D V ++++ + + AV C + G +A+S+ D + ++ + R T
Sbjct: 415 DTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
Query: 438 EEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
HT V ++F + L++ S DK+++I++
Sbjct: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
>AF310672-1|AAM63956.1| 631|Homo sapiens PF20 variant 1a protein.
Length = 631
Score = 93.5 bits (222), Expect = 1e-18
Identities = 65/306 (21%), Positives = 120/306 (39%), Gaps = 17/306 (5%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
KL + H + + + P +L++ +D K+ + N+ T GH W+ F
Sbjct: 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCF 402
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
P G + + S D TV++WDL + C TF+ H+ VW +++ N
Sbjct: 403 HPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGN------------- 449
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
++ + LD K+W + + TL GH V S+ P T+
Sbjct: 450 -FVASSSLDKTSKIWDVNSERCRC--TLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G + + + +F P G +A+ G ++ +D
Sbjct: 507 ARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGN 566
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDG 380
V + GR +A + G ++L D+ G+ +H + H ++ FS ++L S +DG
Sbjct: 567 EVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDG 625
Query: 381 YVNVYN 386
V ++
Sbjct: 626 TVRTWS 631
Score = 81.4 bits (192), Expect = 6e-15
Identities = 67/287 (23%), Positives = 113/287 (39%), Gaps = 17/287 (5%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V+ P + S D + + + + ++ T GH + CF P L T S D
Sbjct: 358 VSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTT 417
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL+D+ + T GH+ V S + G S S D+T ++WD++S +C+ T H
Sbjct: 418 VKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGH 477
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
D V ++F SN +++ S DK + +W E +L GH
Sbjct: 478 TDSVNSIEFFPFSNTLLTSSADK--------------TLSIWDARTGICE--QSLYGHMH 521
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
+ P G IA I I S ++ F G +A
Sbjct: 522 SINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQAS 581
Query: 294 HTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSV 340
G + + + +G + K++ + +V +S DG + SG G+V
Sbjct: 582 GNGVIHLLDLKSGEIHKLMGHENE-AHTVVFSHDGEILFSGGSDGTV 627
Score = 64.1 bits (149), Expect = 1e-09
Identities = 44/158 (27%), Positives = 68/158 (43%), Gaps = 3/158 (1%)
Query: 5 GLTDVWTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
G TD W D F P G + + S + ++ + +G + + S + G +
Sbjct: 392 GHTD-WLSDCCFHPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNF 450
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+AS +LD I+DV + TL GH S+ S+ F P S LLT S D + ++D
Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+L GH + F P G S A ++WD
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548
Score = 61.7 bits (143), Expect = 6e-09
Identities = 49/227 (21%), Positives = 92/227 (40%), Gaps = 2/227 (0%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
PS D + T D VK+W + + T EGH V S G +A
Sbjct: 404 PSGDKLATSSGDTTVKLWDLCTG--DCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSK 461
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ + + + I F P + + T ++++ G ++ L
Sbjct: 462 IWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMH 521
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
I + P G IAS G L+D + + +I+ + F ++LA AS
Sbjct: 522 SINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQAS 581
Query: 378 NDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIR 424
+G +++ +++S + + H+ A +V FS DG+ + + +DG++R
Sbjct: 582 GNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVR 628
Score = 54.0 bits (124), Expect = 1e-06
Identities = 36/154 (23%), Positives = 68/154 (44%), Gaps = 4/154 (2%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVY 341
F P G ++AT V ++ + G + + + S W G ++AS + +
Sbjct: 402 FHPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSK 461
Query: 342 LFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKC 400
++DV+ + T+ H +V S+ F P + L ++S D +++++ + + L H
Sbjct: 462 IWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMH 521
Query: 401 WAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
F P G +A+ A G V L +FR L
Sbjct: 522 SINDAIFDPRGHMIASCDACG---VTKLWDFRKL 552
Score = 52.0 bits (119), Expect = 4e-06
Identities = 31/122 (25%), Positives = 54/122 (44%), Gaps = 1/122 (0%)
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCF 407
K+ + H V ++ P +L S D V + L H W CF
Sbjct: 343 KLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCF 402
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
P G ++ATS+ D ++++ L + TFE H+ V +++ G+ + S S DK+ I
Sbjct: 403 HPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKI 462
Query: 468 YE 469
++
Sbjct: 463 WD 464
Score = 49.2 bits (112), Expect = 3e-05
Identities = 40/156 (25%), Positives = 69/156 (44%), Gaps = 2/156 (1%)
Query: 5 GLTD-VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI 63
G TD V +++F P +++ S + I+ +G EQ L + P G I
Sbjct: 476 GHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI 535
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN 123
AS G+ ++D + + +++ + F ++L S +G + L D+
Sbjct: 536 ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE 595
Query: 124 LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ L GH + +V FS DG+ SG +D TVR W
Sbjct: 596 IH-KLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 45.2 bits (102), Expect = 5e-04
Identities = 43/194 (22%), Positives = 72/194 (37%), Gaps = 1/194 (0%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
FE VW+ + G V S S I+ V S + L S+ + P
Sbjct: 432 FEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSN 491
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
+ + + D ++I+D G +L GH SI F P ++ + G KL+D
Sbjct: 492 TLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
++ S V F G+ S + + + DL S + H H ++ V
Sbjct: 552 LLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVV 610
Query: 182 FNAESNKIISVSED 195
F+ + + S D
Sbjct: 611 FSHDGEILFSGGSD 624
Score = 41.9 bits (94), Expect = 0.005
Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 1/142 (0%)
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
++ + P G +A+ + +V L+D+ G + T E H++AV S + +AS+S
Sbjct: 396 WLSDCCFHPSGDKLATSSGDTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSS 455
Query: 378 NDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D ++++ S + L H S+ F P + TS+AD ++ + +
Sbjct: 456 LDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQS 515
Query: 437 FEEHTHIVCGVQFNADGSKLVS 458
H H + F+ G + S
Sbjct: 516 LYGHMHSINDAIFDPRGHMIAS 537
Score = 34.3 bits (75), Expect = 0.97
Identities = 32/152 (21%), Positives = 66/152 (43%), Gaps = 1/152 (0%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V+ P + S E + + + +L T H + F P LA++S
Sbjct: 355 VSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 414
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMATSAADGSIRVVLLEEFRVLHTF 437
D V ++++ + + AV C + G +A+S+ D + ++ + R T
Sbjct: 415 DTTVKLWDLCTGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
Query: 438 EEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
HT V ++F + L++ S DK+++I++
Sbjct: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
>AB209608-1|BAD92845.1| 540|Homo sapiens transducin beta-like 1X
variant protein.
Length = 540
Score = 93.5 bits (222), Expect = 1e-18
Identities = 85/368 (23%), Positives = 152/368 (41%), Gaps = 41/368 (11%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL----------SGH---- 131
L GH + ++P S LL +GS D +++++ + G+ GH
Sbjct: 191 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 250
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIIS 191
V S+ ++ +G +GS D R+W D T +H ++ +K+N + N
Sbjct: 251 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKGN---- 305
Query: 192 VSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXX 251
YI++ G+D +W E H P + V + T A
Sbjct: 306 ----------YILSAGVDKTTIIWDAHTG--EAKQQFPFHSAPALDVDWQ-NNTTFASCS 352
Query: 252 XXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
+ ++ Q ++++ I + P G +A+ + ++ +
Sbjct: 353 TDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 412
Query: 312 LDTRGKFIMSVAWSPDGR---------YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVR 362
L K I ++ WSP G +AS + +V L+D+ +G HT+ H + V
Sbjct: 413 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 472
Query: 363 SLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGS 422
S+AFSP K LAS S D V+++N +S L + VC++ G ++ SA+DGS
Sbjct: 473 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGS 532
Query: 423 IRVVLLEE 430
+ V+ L +
Sbjct: 533 VCVLDLRK 540
Score = 88.6 bits (210), Expect = 4e-17
Identities = 80/363 (22%), Positives = 158/363 (43%), Gaps = 21/363 (5%)
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ---CQHTFKEHNDQ 176
+ ++ A L GH S V A++P SGS D T R+W+L+ H +
Sbjct: 183 IPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIR 242
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVV 236
G + SNK ++ S D + + TG D ++W+ + N L TL H+ P+
Sbjct: 243 EGG--HDVPSNKDVT-SLDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQHKGPIF 296
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
++ + G I G+ ++ S+ + + + + A+
Sbjct: 297 ALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDM 355
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ V + K + ++ W P G +AS ++ ++ ++ + Q +H ++A
Sbjct: 356 CIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQA 415
Query: 357 HAQAVRSLAFSP---------KTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVC 406
H + + ++ +SP +LASAS D V +++IE + L H+ SV
Sbjct: 416 HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVA 475
Query: 407 FSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSIN 466
FSPDG+ +A+ + D + + + ++H++ T + V +NA G K+ + + D S+
Sbjct: 476 FSPDGKYLASGSFDKCVHIWNTQSGNLVHSY-RGTGGIFEVCWNARGDKVGASASDGSVC 534
Query: 467 IYE 469
+ +
Sbjct: 535 VLD 537
Score = 83.0 bits (196), Expect = 2e-15
Identities = 64/293 (21%), Positives = 121/293 (41%), Gaps = 10/293 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV +LD++ +G + +GS G I+ E G L ++ ++ G YI S
Sbjct: 253 DVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 311
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
+D I+D G+ H+ + + ++ + S D + + + T
Sbjct: 312 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 370
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
GH + V ++ + P G S S D T+++W + C H + HN +++ +K++
Sbjct: 371 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP--- 427
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ S + + D+ V++W E HTL H+ PV SVA SPDG+ +
Sbjct: 428 --TGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAFSPDGKYL 483
Query: 248 AXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTV 300
A G + + + ++++ ++ G +V G V V
Sbjct: 484 ASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCWNARGDKVGASASDGSVCV 535
Score = 54.0 bits (124), Expect = 1e-06
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 1/97 (1%)
Query: 23 SGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKL 82
S S + ++ +E G L + SVA+SPDGKY+ASG+ D ++I++ G L
Sbjct: 443 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 502
Query: 83 VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
VH+ G I +C++ + + DG + + D+
Sbjct: 503 VHSYRGTG-GIFEVCWNARGDKVGASASDGSVCVLDL 538
>AB053276-1|BAB69430.1| 348|Homo sapiens TUWD12 protein.
Length = 348
Score = 93.5 bits (222), Expect = 1e-18
Identities = 51/162 (31%), Positives = 80/162 (49%), Gaps = 2/162 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S I I+ + + F V ++P G IAS D +
Sbjct: 22 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 81
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV KL+ + H+ + + F P L+T S DG +K+ D++ L TL GH
Sbjct: 82 VWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG 141
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEH 173
V +V+FS G+ F SG AD V +W + D + C+ K +
Sbjct: 142 PVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRN 183
Score = 74.5 bits (175), Expect = 7e-13
Identities = 45/168 (26%), Positives = 82/168 (48%), Gaps = 16/168 (9%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +++L H +R FSPD +L+++ S+D +K++D + S + V F
Sbjct: 5 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDF 64
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G S +D+TV+VWD+ + ++ H+ V + F+ PS
Sbjct: 65 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH--------------PSG 110
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
+Y++T D +K+ +L ++TL+GH PV +V+ S GE A
Sbjct: 111 NYLITASSDGTLKILDLLEGRL--IYTLQGHTGPVFTVSFSKGGELFA 156
Score = 69.3 bits (162), Expect = 3e-11
Identities = 38/152 (25%), Positives = 77/152 (50%), Gaps = 1/152 (0%)
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
++ +SPDGR I S +E ++ ++D + + ++ + F+P +ASA
Sbjct: 16 WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAG 75
Query: 378 NDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
+D V V+++ + LQ+ H + F P G + T+++DG+++++ L E R+++T
Sbjct: 76 SDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 135
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ HT V V F+ G S D + ++
Sbjct: 136 LQGHTGPVFTVSFSKGGELFASGGADTQVLLW 167
Score = 60.9 bits (141), Expect = 1e-08
Identities = 27/106 (25%), Positives = 54/106 (50%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
+DF+P G + S + + ++ V K Q +++ P G Y+ + + DG
Sbjct: 62 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 121
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
+ I D+ +G+L++TL+GH + ++ FS +L +G D + L+
Sbjct: 122 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 167
Score = 59.7 bits (138), Expect = 2e-08
Identities = 39/144 (27%), Positives = 67/144 (46%), Gaps = 3/144 (2%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSV 340
FSPDG + + + ++ N V+ D+ G F V ++P G IAS +V
Sbjct: 22 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG-FANFVDFNPSGTCIASAGSDQTV 80
Query: 341 YLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN-IESAALQNKLDHK 399
++DV K+L + H+ V ++F P L +AS+DG + + + +E + H
Sbjct: 81 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHT 140
Query: 400 CWAVSVCFSPDGQRMATSAADGSI 423
+V FS G+ A+ AD +
Sbjct: 141 GPVFTVSFSKGGELFASGGADTQV 164
Score = 58.8 bits (136), Expect = 4e-08
Identities = 33/128 (25%), Positives = 60/128 (46%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMK 115
+SPDG+ I S + D I I+D + V+ + F+P + + D +K
Sbjct: 22 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 81
Query: 116 LYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHND 175
++DV L H+ V ++F P G ++ S+D T+++ DL + +T + H
Sbjct: 82 VWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG 141
Query: 176 QVWGVKFN 183
V+ V F+
Sbjct: 142 PVFTVSFS 149
Score = 37.5 bits (83), Expect = 0.10
Identities = 16/72 (22%), Positives = 35/72 (48%)
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
H W FSPDG+ + + + D +I++ + ++ F + V FN G+ +
Sbjct: 13 HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIA 72
Query: 458 SVSKDKSINIYE 469
S D+++ +++
Sbjct: 73 SAGSDQTVKVWD 84
Score = 35.9 bits (79), Expect = 0.32
Identities = 16/38 (42%), Positives = 25/38 (65%)
Query: 432 RVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
R L++ HTH V +F+ DG +VS S+DK+I I++
Sbjct: 5 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 42
>AB053266-1|BAB69057.1| 348|Homo sapiens TUWD12 protein.
Length = 348
Score = 93.5 bits (222), Expect = 1e-18
Identities = 51/162 (31%), Positives = 80/162 (49%), Gaps = 2/162 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPDG+ ++S S I I+ + + F V ++P G IAS D +
Sbjct: 22 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 81
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
++DV KL+ + H+ + + F P L+T S DG +K+ D++ L TL GH
Sbjct: 82 VWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG 141
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEH 173
V +V+FS G+ F SG AD V +W + D + C+ K +
Sbjct: 142 PVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRN 183
Score = 74.5 bits (175), Expect = 7e-13
Identities = 45/168 (26%), Positives = 82/168 (48%), Gaps = 16/168 (9%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
+ +++L H +R FSPD +L+++ S+D +K++D + S + V F
Sbjct: 5 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDF 64
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G S +D+TV+VWD+ + ++ H+ V + F+ PS
Sbjct: 65 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFH--------------PSG 110
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
+Y++T D +K+ +L ++TL+GH PV +V+ S GE A
Sbjct: 111 NYLITASSDGTLKILDLLEGRL--IYTLQGHTGPVFTVSFSKGGELFA 156
Score = 69.3 bits (162), Expect = 3e-11
Identities = 38/152 (25%), Positives = 77/152 (50%), Gaps = 1/152 (0%)
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
++ +SPDGR I S +E ++ ++D + + ++ + F+P +ASA
Sbjct: 16 WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAG 75
Query: 378 NDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
+D V V+++ + LQ+ H + F P G + T+++DG+++++ L E R+++T
Sbjct: 76 SDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 135
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ HT V V F+ G S D + ++
Sbjct: 136 LQGHTGPVFTVSFSKGGELFASGGADTQVLLW 167
Score = 60.9 bits (141), Expect = 1e-08
Identities = 27/106 (25%), Positives = 54/106 (50%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
+DF+P G + S + + ++ V K Q +++ P G Y+ + + DG
Sbjct: 62 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 121
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
+ I D+ +G+L++TL+GH + ++ FS +L +G D + L+
Sbjct: 122 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 167
Score = 59.7 bits (138), Expect = 2e-08
Identities = 39/144 (27%), Positives = 67/144 (46%), Gaps = 3/144 (2%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSV 340
FSPDG + + + ++ N V+ D+ G F V ++P G IAS +V
Sbjct: 22 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG-FANFVDFNPSGTCIASAGSDQTV 80
Query: 341 YLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN-IESAALQNKLDHK 399
++DV K+L + H+ V ++F P L +AS+DG + + + +E + H
Sbjct: 81 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHT 140
Query: 400 CWAVSVCFSPDGQRMATSAADGSI 423
+V FS G+ A+ AD +
Sbjct: 141 GPVFTVSFSKGGELFASGGADTQV 164
Score = 58.8 bits (136), Expect = 4e-08
Identities = 33/128 (25%), Positives = 60/128 (46%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMK 115
+SPDG+ I S + D I I+D + V+ + F+P + + D +K
Sbjct: 22 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 81
Query: 116 LYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHND 175
++DV L H+ V ++F P G ++ S+D T+++ DL + +T + H
Sbjct: 82 VWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG 141
Query: 176 QVWGVKFN 183
V+ V F+
Sbjct: 142 PVFTVSFS 149
Score = 37.5 bits (83), Expect = 0.10
Identities = 16/72 (22%), Positives = 35/72 (48%)
Query: 398 HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
H W FSPDG+ + + + D +I++ + ++ F + V FN G+ +
Sbjct: 13 HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIA 72
Query: 458 SVSKDKSINIYE 469
S D+++ +++
Sbjct: 73 SAGSDQTVKVWD 84
Score = 35.9 bits (79), Expect = 0.32
Identities = 16/38 (42%), Positives = 25/38 (65%)
Query: 432 RVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
R L++ HTH V +F+ DG +VS S+DK+I I++
Sbjct: 5 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 42
>BC031227-1|AAH31227.2| 452|Homo sapiens WDR88 protein protein.
Length = 452
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/199 (31%), Positives = 98/199 (49%), Gaps = 9/199 (4%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGK-ILIFGVESGKQEQVL-DTRGKFTLSVAYSPDGKYIA 64
T + + FSPDGK+V+SG + I I E+ V+ D + S + PD + +A
Sbjct: 213 TFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVA 272
Query: 65 SGALDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN 123
S +LD I I+DV +Q L+ + H+ +I + CF+ L T S D ++K+++V
Sbjct: 273 SVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGE 332
Query: 124 LAGT------LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
+ GH V S F+ D +SG DRTV +WD+ + + K HND V
Sbjct: 333 FRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWV 392
Query: 178 WGVKFNAESNKIISVSEDK 196
V + I+S S+D+
Sbjct: 393 MDVAISNNKKWILSASKDR 411
Score = 79.4 bits (187), Expect = 3e-14
Identities = 63/228 (27%), Positives = 105/228 (46%), Gaps = 14/228 (6%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA-LDGIINIF 75
D VI+ S + + +E+GK + F +S +SPDGKY+ SG +D I I
Sbjct: 182 DSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 240
Query: 76 DVAQGKLVHTLEGH-AMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV-HANLAGTLSGHAS 133
D V ++ H SI S CF PDSQ + + S D +K++DV A L H++
Sbjct: 241 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 300
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ + F+ G + S D+ +++W++ HT + N + S
Sbjct: 301 AISNCCFTFSGHFLCTSSWDKNLKIWNV------HTGEFRNCGACVTLMQGHEGSVSSCH 354
Query: 194 EDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
+ S ++++GG D V +W +L +L+GH V+ VA+S
Sbjct: 355 FARDSS--FLISGGFDRTVAIWDVAEGYRKL--SLKGHNDWVMDVAIS 398
Score = 69.3 bits (162), Expect = 3e-11
Identities = 45/158 (28%), Positives = 78/158 (49%), Gaps = 7/158 (4%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGII 72
F PD + V S S I I+ V S + +S ++ G ++ + + D +
Sbjct: 264 FDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNL 323
Query: 73 NIFDVAQGKL------VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
I++V G+ V ++GH S+ S F+ DS L++G D + ++DV
Sbjct: 324 KIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKL 383
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSM 164
+L GH WV+ VA S + K +S S DRT+R+W+++ +
Sbjct: 384 SLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEI 421
Score = 67.3 bits (157), Expect = 1e-10
Identities = 68/313 (21%), Positives = 129/313 (41%), Gaps = 27/313 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW-VLSVAFSPDG 144
L GH ++ + F D LL+GS D +KL+D V ++ V+ + + D
Sbjct: 124 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 183
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
R ++ S D+TVR WDL E +W V+++ VS P Y+V
Sbjct: 184 SRVIAASYDKTVRAWDL----------ETGKLLWKVRYDT-----FIVSCKFSPDGKYVV 228
Query: 205 TG-GLDNLVKVWSYENNKLELLHTLEGHE-MPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+G +D+ + + EN + + ++ H + S PD + +A
Sbjct: 229 SGFDVDHGICIMDAEN--ITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 286
Query: 263 XGQKIREI-QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK------VLDTR 315
+ I + S+ + F+ G + T + ++ + G ++
Sbjct: 287 SQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGH 346
Query: 316 GKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
+ S ++ D ++ SG +V ++DV++G +++ H V +A S K + S
Sbjct: 347 EGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILS 406
Query: 376 ASNDGYVNVYNIE 388
AS D + ++NIE
Sbjct: 407 ASKDRTMRLWNIE 419
Score = 60.9 bits (141), Expect = 1e-08
Identities = 59/278 (21%), Positives = 125/278 (44%), Gaps = 16/278 (5%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGH-EMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+++G D VK+W + + + E + PVV +++ D +
Sbjct: 143 LLSGSYDCTVKLWDPVDGSV--VRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDL 200
Query: 262 XXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK-VTVYGIIN-GTVDKVLDTRGKFI 319
G+ + +++ D+ + FSPDG V +G + + N TV + D + I
Sbjct: 201 ETGKLLWKVRYDTFIV-SCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSI 259
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
S + PD + +AS + + ++DV SQ +L +AH+ A+ + F+ L ++S
Sbjct: 260 TSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSW 319
Query: 379 DGYVNVYNIESAALQN------KLDHKCWAVSVC-FSPDGQRMATSAADGSIRV-VLLEE 430
D + ++N+ + +N + +VS C F+ D + + D ++ + + E
Sbjct: 320 DKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG 379
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+R L + + H V V + + ++S SKD+++ ++
Sbjct: 380 YRKL-SLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 416
Score = 52.8 bits (121), Expect = 3e-06
Identities = 39/163 (23%), Positives = 77/163 (47%), Gaps = 3/163 (1%)
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQA-VRSLAFSP 368
K+L + + + D + SG+ +V L+D G ++ E +A V + +
Sbjct: 122 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 181
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSA-ADGSIRVVL 427
+ + +AS D V +++E+ L K+ + + VS FSPDG+ + + D I ++
Sbjct: 182 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMD 241
Query: 428 LEEFRVLHTFEEH-THIVCGVQFNADGSKLVSVSKDKSINIYE 469
E + ++H T + F+ D ++ SVS D+ I I++
Sbjct: 242 AENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWD 284
>AK131444-1|BAD18589.1| 472|Homo sapiens protein ( Homo sapiens
cDNA FLJ16579 fis, clone TESTI2049956, weakly similar
to Vegetatible incompatibility protein HET-E-1. ).
Length = 472
Score = 93.1 bits (221), Expect = 2e-18
Identities = 62/199 (31%), Positives = 98/199 (49%), Gaps = 9/199 (4%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGK-ILIFGVESGKQEQVL-DTRGKFTLSVAYSPDGKYIA 64
T + + FSPDGK+V+SG + I I E+ V+ D + S + PD + +A
Sbjct: 187 TFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVA 246
Query: 65 SGALDGIINIFDV-AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN 123
S +LD I I+DV +Q L+ + H+ +I + CF+ L T S D ++K+++V
Sbjct: 247 SVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGE 306
Query: 124 LAGT------LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
+ GH V S F+ D +SG DRTV +WD+ + + K HND V
Sbjct: 307 FRNRGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWV 366
Query: 178 WGVKFNAESNKIISVSEDK 196
V + I+S S+D+
Sbjct: 367 MDVAISNNKKWILSASKDR 385
Score = 79.8 bits (188), Expect = 2e-14
Identities = 63/228 (27%), Positives = 105/228 (46%), Gaps = 14/228 (6%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA-LDGIINIF 75
D VI+ S + + +E+GK + F +S +SPDGKY+ SG +D I I
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
Query: 76 DVAQGKLVHTLEGH-AMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV-HANLAGTLSGHAS 133
D V ++ H SI S CF PDSQ + + S D +K++DV A L H++
Sbjct: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
+ + F+ G + S D+ +++W++ HT + N + S
Sbjct: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNV------HTGEFRNRGACVTLMQGHEGSVSSCH 328
Query: 194 EDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVS 241
+ S ++++GG D V +W +L +L+GH V+ VA+S
Sbjct: 329 FARDSS--FLISGGFDRTVAIWDVAEGYRKL--SLKGHNDWVMDVAIS 372
Score = 69.3 bits (162), Expect = 3e-11
Identities = 45/158 (28%), Positives = 78/158 (49%), Gaps = 7/158 (4%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGII 72
F PD + V S S I I+ V S + +S ++ G ++ + + D +
Sbjct: 238 FDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNL 297
Query: 73 NIFDVAQGKL------VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
I++V G+ V ++GH S+ S F+ DS L++G D + ++DV
Sbjct: 298 KIWNVHTGEFRNRGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKL 357
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSM 164
+L GH WV+ VA S + K +S S DRT+R+W+++ +
Sbjct: 358 SLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEI 395
Score = 67.3 bits (157), Expect = 1e-10
Identities = 68/313 (21%), Positives = 129/313 (41%), Gaps = 27/313 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW-VLSVAFSPDG 144
L GH ++ + F D LL+GS D +KL+D V ++ V+ + + D
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
R ++ S D+TVR WDL E +W V+++ VS P Y+V
Sbjct: 158 SRVIAASYDKTVRAWDL----------ETGKLLWKVRYDT-----FIVSCKFSPDGKYVV 202
Query: 205 TG-GLDNLVKVWSYENNKLELLHTLEGHE-MPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+G +D+ + + EN + + ++ H + S PD + +A
Sbjct: 203 SGFDVDHGICIMDAEN--ITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
Query: 263 XGQKIREI-QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDK------VLDTR 315
+ I + S+ + F+ G + T + ++ + G ++
Sbjct: 261 SQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNRGACVTLMQGH 320
Query: 316 GKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
+ S ++ D ++ SG +V ++DV++G +++ H V +A S K + S
Sbjct: 321 EGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILS 380
Query: 376 ASNDGYVNVYNIE 388
AS D + ++NIE
Sbjct: 381 ASKDRTMRLWNIE 393
Score = 62.5 bits (145), Expect = 3e-09
Identities = 59/278 (21%), Positives = 126/278 (45%), Gaps = 16/278 (5%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHTLEGH-EMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+++G D VK+W + + + E + PVV +++ D +
Sbjct: 117 LLSGSYDCTVKLWDPVDGSV--VRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDL 174
Query: 262 XXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK-VTVYGIIN-GTVDKVLDTRGKFI 319
G+ + +++ D+ + FSPDG V +G + + N TV + D + I
Sbjct: 175 ETGKLLWKVRYDTFIV-SCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSI 233
Query: 320 MSVAWSPDGRYIASGAEGGSVYLFDV-SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
S + PD + +AS + + ++DV SQ +L +AH+ A+ + F+ L ++S
Sbjct: 234 TSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSW 293
Query: 379 DGYVNVYNIESAALQNK------LDHKCWAVSVC-FSPDGQRMATSAADGSIRV-VLLEE 430
D + ++N+ + +N+ + +VS C F+ D + + D ++ + + E
Sbjct: 294 DKNLKIWNVHTGEFRNRGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG 353
Query: 431 FRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+R L + + H V V + + ++S SKD+++ ++
Sbjct: 354 YRKL-SLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
Score = 52.8 bits (121), Expect = 3e-06
Identities = 39/163 (23%), Positives = 77/163 (47%), Gaps = 3/163 (1%)
Query: 310 KVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQA-VRSLAFSP 368
K+L + + + D + SG+ +V L+D G ++ E +A V + +
Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSA-ADGSIRVVL 427
+ + +AS D V +++E+ L K+ + + VS FSPDG+ + + D I ++
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMD 215
Query: 428 LEEFRVLHTFEEH-THIVCGVQFNADGSKLVSVSKDKSINIYE 469
E + ++H T + F+ D ++ SVS D+ I I++
Sbjct: 216 AENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWD 258
>BC025379-1|AAH25379.1| 571|Homo sapiens SPAG16 protein protein.
Length = 571
Score = 92.7 bits (220), Expect = 3e-18
Identities = 65/306 (21%), Positives = 119/306 (38%), Gaps = 17/306 (5%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
KL + H + + + P +L++ +D K+ + N+ T GH W+ F
Sbjct: 283 KLKNIFRLHELPVSCVSMHPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCF 342
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
P G + + S D TV++WDL C TF+ H+ VW +++ N
Sbjct: 343 HPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGN------------- 389
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
++ + LD K+W + + TL GH V S+ P T+
Sbjct: 390 -FVASSSLDKTSKIWDVNSERCRC--TLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 446
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G + + + +F P G +A+ G ++ +D
Sbjct: 447 ARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGN 506
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDG 380
V + GR +A + G ++L D+ G+ +H + H ++ FS ++L S +DG
Sbjct: 507 EVNFDSSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDG 565
Query: 381 YVNVYN 386
V ++
Sbjct: 566 TVRTWS 571
Score = 81.4 bits (192), Expect = 6e-15
Identities = 67/287 (23%), Positives = 113/287 (39%), Gaps = 17/287 (5%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
V+ P + S D + + + + ++ T GH + CF P L T S D
Sbjct: 298 VSMHPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTT 357
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+KL+D+ + T GH+ V S + G S S D+T ++WD++S +C+ T H
Sbjct: 358 VKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGH 417
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
D V ++F SN +++ S DK + +W E +L GH
Sbjct: 418 TDSVNSIEFFPFSNTLLTSSADK--------------TLSIWDARTGICE--QSLYGHMH 461
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
+ P G IA I I S ++ F G +A
Sbjct: 462 SINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQAS 521
Query: 294 HTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSV 340
G + + + +G + K++ + +V +S DG + SG G+V
Sbjct: 522 GNGVIHLLDLKSGEIHKLMGHENE-AHTVVFSHDGEILFSGGSDGTV 567
Score = 63.7 bits (148), Expect = 1e-09
Identities = 44/158 (27%), Positives = 67/158 (42%), Gaps = 3/158 (1%)
Query: 5 GLTDVWTLD--FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
G TD W D F P G + + S + ++ + G + + S + G +
Sbjct: 332 GHTD-WLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNF 390
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
+AS +LD I+DV + TL GH S+ S+ F P S LLT S D + ++D
Sbjct: 391 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 450
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
+L GH + F P G S A ++WD
Sbjct: 451 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 488
Score = 62.5 bits (145), Expect = 3e-09
Identities = 50/227 (22%), Positives = 93/227 (40%), Gaps = 2/227 (0%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
PS D + T D VK+W K + + T EGH V S G +A
Sbjct: 344 PSGDKLATSSGDTTVKLWDL--CKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSK 401
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ + + + I F P + + T ++++ G ++ L
Sbjct: 402 IWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMH 461
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
I + P G IAS G L+D + + +I+ + F ++LA AS
Sbjct: 462 SINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQAS 521
Query: 378 NDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIR 424
+G +++ +++S + + H+ A +V FS DG+ + + +DG++R
Sbjct: 522 GNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVR 568
Score = 54.0 bits (124), Expect = 1e-06
Identities = 36/154 (23%), Positives = 68/154 (44%), Gaps = 4/154 (2%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVY 341
F P G ++AT V ++ + G + + + S W G ++AS + +
Sbjct: 342 FHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSK 401
Query: 342 LFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKC 400
++DV+ + T+ H +V S+ F P + L ++S D +++++ + + L H
Sbjct: 402 IWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMH 461
Query: 401 WAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVL 434
F P G +A+ A G V L +FR L
Sbjct: 462 SINDAIFDPRGHMIASCDACG---VTKLWDFRKL 492
Score = 52.4 bits (120), Expect = 3e-06
Identities = 31/122 (25%), Positives = 55/122 (45%), Gaps = 1/122 (0%)
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA-ALQNKLDHKCWAVSVCF 407
K+ + H V ++ P +L S D V + L H W CF
Sbjct: 283 KLKNIFRLHELPVSCVSMHPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCF 342
Query: 408 SPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINI 467
P G ++ATS+ D ++++ L + + TFE H+ V +++ G+ + S S DK+ I
Sbjct: 343 HPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKI 402
Query: 468 YE 469
++
Sbjct: 403 WD 404
Score = 49.2 bits (112), Expect = 3e-05
Identities = 40/156 (25%), Positives = 69/156 (44%), Gaps = 2/156 (1%)
Query: 5 GLTD-VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI 63
G TD V +++F P +++ S + I+ +G EQ L + P G I
Sbjct: 416 GHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMI 475
Query: 64 ASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN 123
AS G+ ++D + + +++ + F ++L S +G + L D+
Sbjct: 476 ASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGE 535
Query: 124 LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ L GH + +V FS DG+ SG +D TVR W
Sbjct: 536 IH-KLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 570
Score = 45.2 bits (102), Expect = 5e-04
Identities = 43/194 (22%), Positives = 72/194 (37%), Gaps = 1/194 (0%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGK 61
FE VW+ + G V S S I+ V S + L S+ + P
Sbjct: 372 FEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSN 431
Query: 62 YIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH 121
+ + + D ++I+D G +L GH SI F P ++ + G KL+D
Sbjct: 432 TLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 491
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVK 181
++ S V F G+ S + + + DL S + H H ++ V
Sbjct: 492 LLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVV 550
Query: 182 FNAESNKIISVSED 195
F+ + + S D
Sbjct: 551 FSHDGEILFSGGSD 564
Score = 42.7 bits (96), Expect = 0.003
Identities = 32/142 (22%), Positives = 63/142 (44%), Gaps = 1/142 (0%)
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
++ + P G +A+ + +V L+D+ +G + T E H++AV S + +AS+S
Sbjct: 336 WLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSS 395
Query: 378 NDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D ++++ S + L H S+ F P + TS+AD ++ + +
Sbjct: 396 LDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQS 455
Query: 437 FEEHTHIVCGVQFNADGSKLVS 458
H H + F+ G + S
Sbjct: 456 LYGHMHSINDAIFDPRGHMIAS 477
Score = 33.5 bits (73), Expect = 1.7
Identities = 32/152 (21%), Positives = 65/152 (42%), Gaps = 1/152 (0%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V+ P + S E + + + +L T H + F P LA++S
Sbjct: 295 VSCVSMHPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSG 354
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMATSAADGSIRVVLLEEFRVLHTF 437
D V ++++ + AV C + G +A+S+ D + ++ + R T
Sbjct: 355 DTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 414
Query: 438 EEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
HT V ++F + L++ S DK+++I++
Sbjct: 415 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 446
>U86136-1|AAC51107.1| 2627|Homo sapiens telomerase-associated protein
TP-1 protein.
Length = 2627
Score = 92.3 bits (219), Expect = 3e-18
Identities = 114/475 (24%), Positives = 198/475 (41%), Gaps = 43/475 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQ-VLDTRGKFTLSVAYSPDGKYIASGALDGII 72
FS +G+ G+ G + + + + ++E+ V+ + + S D ++ A DG++
Sbjct: 1684 FSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT--AFDGLL 1741
Query: 73 NIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA 132
++D+ G V + H I C SPD +LL T G +KL+D V LA + +
Sbjct: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHT-YP 1800
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+ VAF P+G+ +GS ++ + +D ++ + + FN
Sbjct: 1801 KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGG----- 1855
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
+ G LD++V++W++ L H V + G +
Sbjct: 1856 ---------VVAVGRLDSMVELWAWREG--ARLAAFPAHHGFVAAALFLHAGCQLLTAGE 1904
Query: 253 XXXXXXXXXXXGQKIREIQTDS-SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
G+ + + S S + SPDG +VA G + +Y I +G+
Sbjct: 1905 DGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQ 1964
Query: 312 LDTRGKFIMSVAW-SPDGRYIASGAEGGSVYLFDVSQGKM--LHTIEAHAQAVRSLAFSP 368
+ ++AW SP + + SGAE GS+ + + + + L + + V LA S
Sbjct: 1965 GQALDVAVSALAWLSP--KVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATS- 2021
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWA--------VSVC-FSPDGQRMATSA 418
+LLASAS D V ++ + +K D C VS C FS DG +AT
Sbjct: 2022 -QELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGG 2080
Query: 419 ADGSIRV--VLLEEFRVL-HTFEE-HTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
D S+ V + VL H+F H V G + D + L+S S D S+ +++
Sbjct: 2081 RDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKD-NLLISCSSDGSVGLWD 2134
Score = 82.6 bits (195), Expect = 3e-15
Identities = 108/480 (22%), Positives = 192/480 (40%), Gaps = 41/480 (8%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P+G+ + +GS AG I F V+ K + L G ++A++ G +A G LD ++
Sbjct: 1808 FHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVE 1867
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA- 132
++ +G + H + + F LLT +DG ++++ G L +
Sbjct: 1868 LWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSL 1927
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
S LSVA SPDG R G +R++ + S Q G + A ++V
Sbjct: 1928 SPALSVALSPDGDRVAVGYRADGIRIYKISS----------GSQ--GAQGQALD---VAV 1972
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
S S +V+G D ++ W+ + L+ L L + PV+ +A S + A
Sbjct: 1973 SALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDF 2032
Query: 253 XXXXX-XXXXXXGQKIR------EIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIIN 305
K E++ + FS DG +ATGG + + +
Sbjct: 2033 TVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRT 2092
Query: 306 GTVDKVLDT----RGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
++ + ++ AW+ D I+ ++G SV L+D G+ L H AV
Sbjct: 2093 PKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDG-SVGLWDPESGQRLGQFLGHQSAV 2151
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMA------ 415
++A + + S S DG + V++ + L + H +S C + R A
Sbjct: 2152 SAVA--AVEEHVVSVSRDGTLKVWDHQGVELTSIPAHS-GPISHCAAAMEPRAAGQPGSE 2208
Query: 416 ----TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYECP 471
T DG+ R+ HT H+ V + +++ S+D S+ +++ P
Sbjct: 2209 LLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVP 2268
Score = 73.3 bits (172), Expect = 2e-12
Identities = 74/291 (25%), Positives = 119/291 (40%), Gaps = 20/291 (6%)
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
+VAFS +G+R G+A+ TV + DL T++E V G +S
Sbjct: 1681 AVAFSTNGQRAAVGTANGTVYLLDL------RTWQEEKSVVSGCD---------GISACL 1725
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
S D + D L+++W ++ +L T + H+ + +SPD +A
Sbjct: 1726 FLSDDTLFLTAFDGLLELWDLQHG-CRVLQT-KAHQYQITGCCLSPDCRLLATVCLGGCL 1783
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
GQ + T + + F P+G +ATG G ++ + + V K L G
Sbjct: 1784 KLWDTVRGQLAFQ-HTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPG 1842
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
I ++A++ G +A G V L+ +G L AH V + F L +A
Sbjct: 1843 ASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTA 1902
Query: 377 SNDGYVNVYNIESAALQNKLDHKCW--AVSVCFSPDGQRMATSAADGSIRV 425
DG V V++ + L A+SV SPDG R+A IR+
Sbjct: 1903 GEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRI 1953
Score = 62.5 bits (145), Expect = 3e-09
Identities = 62/251 (24%), Positives = 106/251 (42%), Gaps = 15/251 (5%)
Query: 55 AYSPDGKYIASGALDGIINIFDVAQGK---LVHTLEG-HAMSIRSLCFSPDSQLLLTGSD 110
++S DG +A+G D + +DV K L+H+ H + ++ D+ LL++ S
Sbjct: 2068 SFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN-LLISCSS 2126
Query: 111 DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF 170
DG + L+D G GH S V +VA + VS S D T++VWD ++ +
Sbjct: 2127 DGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRDGTLKVWDHQGVELT-SI 2183
Query: 171 KEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
H+ + E + + S+ +VT GLD ++W + HTL G
Sbjct: 2184 PAHSGPISHCAAAMEPR-----AAGQPGSELLVVTVGLDGATRLW--HPLLVCQTHTLLG 2236
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H PV + AVS + I S+ + + ++PDGS
Sbjct: 2237 HSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAV 2296
Query: 291 TGGHTGKVTVY 301
+G G++ ++
Sbjct: 2297 SGNQAGELILW 2307
Score = 50.0 bits (114), Expect = 2e-05
Identities = 63/284 (22%), Positives = 103/284 (36%), Gaps = 35/284 (12%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSG----HASWVLSVAFS 141
L GH + FS D L TG D + +DV + H WV A++
Sbjct: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT 2116
Query: 142 PDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKD 201
D +S S+D +V +WD +S Q F H V V A ++SVS D
Sbjct: 2117 KDNL-LISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA--AVEEHVVSVSRD------ 2167
Query: 202 YIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD----GETIAXXXXXXXXX 257
+KVW ++ +L ++ H P+ A + + G+ +
Sbjct: 2168 --------GTLKVWDHQGVELT---SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGL 2216
Query: 258 XXXXXXGQKIREIQTD-----SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVL 312
+ QT S + S + T G V ++ + D +
Sbjct: 2217 DGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCI 2276
Query: 313 DTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ +VAW+PDG SG + G + L+ + K + T +A
Sbjct: 2277 PRSSAAVTAVAWAPDGSMAVSGNQAGELILW--QEAKAVATAQA 2318
Score = 48.8 bits (111), Expect = 4e-05
Identities = 56/204 (27%), Positives = 89/204 (43%), Gaps = 17/204 (8%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAY-SPDGKYIA 64
L+ ++ SPDG V G A I I+ + SG Q ++A+ SP K +
Sbjct: 1927 LSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLV 1984
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD---VVH 121
SGA DG + + + + L L + +LL + S+D ++L+ +
Sbjct: 1985 SGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTR 2044
Query: 122 ANLA-----GT-LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ---HTFKE 172
+ A GT L GH V +FS DG +G DR++ WD+ + + H+F
Sbjct: 2045 PHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPA 2104
Query: 173 -HNDQVWGVKFNAESNKIISVSED 195
H D V G + + N +IS S D
Sbjct: 2105 CHRDWVTGCAW-TKDNLLISCSSD 2127
Score = 42.7 bits (96), Expect = 0.003
Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 5/127 (3%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAV-SVCFSPD 410
HT+ H+ VR+ A S + L+ +AS DG V ++ + A + AV +V ++PD
Sbjct: 2232 HTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPD 2291
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
G MA S ++L +E + + T + HI G + +S D+ I+ ++
Sbjct: 2292 GS-MAVSGNQAG-ELILWQEAKAVATAQAPGHI--GALIWSSAHTFFVLSADEKISEWQV 2347
Query: 471 PIPPKSA 477
+ SA
Sbjct: 2348 KLRKGSA 2354
>BC126107-1|AAI26108.1| 2627|Homo sapiens telomerase-associated
protein 1 protein.
Length = 2627
Score = 92.3 bits (219), Expect = 3e-18
Identities = 114/475 (24%), Positives = 198/475 (41%), Gaps = 43/475 (9%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQ-VLDTRGKFTLSVAYSPDGKYIASGALDGII 72
FS +G+ G+ G + + + + ++E+ V+ + + S D ++ A DG++
Sbjct: 1684 FSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT--AFDGLL 1741
Query: 73 NIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA 132
++D+ G V + H I C SPD +LL T G +KL+D V LA + +
Sbjct: 1742 ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHT-YP 1800
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+ VAF P+G+ +GS ++ + +D ++ + + FN
Sbjct: 1801 KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGG----- 1855
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
+ G LD++V++W++ L H V + G +
Sbjct: 1856 ---------VVAVGRLDSMVELWAWREG--ARLAAFPAHHGFVAAALFLHAGCQLLTAGE 1904
Query: 253 XXXXXXXXXXXGQKIREIQTDS-SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKV 311
G+ + + S S + SPDG +VA G + +Y I +G+
Sbjct: 1905 DGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQ 1964
Query: 312 LDTRGKFIMSVAW-SPDGRYIASGAEGGSVYLFDVSQGKM--LHTIEAHAQAVRSLAFSP 368
+ ++AW SP + + SGAE GS+ + + + + L + + V LA S
Sbjct: 1965 GQALDVAVSALAWLSP--KVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATS- 2021
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKL-DHKCWA--------VSVC-FSPDGQRMATSA 418
+LLASAS D V ++ + +K D C VS C FS DG +AT
Sbjct: 2022 -QELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGG 2080
Query: 419 ADGSIRV--VLLEEFRVL-HTFEE-HTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
D S+ V + VL H+F H V G + D + L+S S D S+ +++
Sbjct: 2081 RDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKD-NLLISCSSDGSVGLWD 2134
Score = 82.6 bits (195), Expect = 3e-15
Identities = 108/480 (22%), Positives = 192/480 (40%), Gaps = 41/480 (8%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
F P+G+ + +GS AG I F V+ K + L G ++A++ G +A G LD ++
Sbjct: 1808 FHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVE 1867
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHA- 132
++ +G + H + + F LLT +DG ++++ G L +
Sbjct: 1868 LWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSL 1927
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
S LSVA SPDG R G +R++ + S Q G + A ++V
Sbjct: 1928 SPALSVALSPDGDRVAVGYRADGIRIYKISS----------GSQ--GAQGQALD---VAV 1972
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
S S +V+G D ++ W+ + L+ L L + PV+ +A S + A
Sbjct: 1973 SALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDF 2032
Query: 253 XXXXX-XXXXXXGQKIR------EIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIIN 305
K E++ + FS DG +ATGG + + +
Sbjct: 2033 TVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRT 2092
Query: 306 GTVDKVLDT----RGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
++ + ++ AW+ D I+ ++G SV L+D G+ L H AV
Sbjct: 2093 PKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDG-SVGLWDPESGQRLGQFLGHQSAV 2151
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMA------ 415
++A + + S S DG + V++ + L + H +S C + R A
Sbjct: 2152 SAVA--AVEEHVVSVSRDGTLKVWDHQGVELTSIPAHS-GPISHCAAAMEPRAAGQPGSE 2208
Query: 416 ----TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYECP 471
T DG+ R+ HT H+ V + +++ S+D S+ +++ P
Sbjct: 2209 LLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVP 2268
Score = 73.3 bits (172), Expect = 2e-12
Identities = 74/291 (25%), Positives = 119/291 (40%), Gaps = 20/291 (6%)
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
+VAFS +G+R G+A+ TV + DL T++E V G +S
Sbjct: 1681 AVAFSTNGQRAAVGTANGTVYLLDL------RTWQEEKSVVSGCD---------GISACL 1725
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
S D + D L+++W ++ +L T + H+ + +SPD +A
Sbjct: 1726 FLSDDTLFLTAFDGLLELWDLQHG-CRVLQT-KAHQYQITGCCLSPDCRLLATVCLGGCL 1783
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
GQ + T + + F P+G +ATG G ++ + + V K L G
Sbjct: 1784 KLWDTVRGQLAFQ-HTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPG 1842
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
I ++A++ G +A G V L+ +G L AH V + F L +A
Sbjct: 1843 ASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTA 1902
Query: 377 SNDGYVNVYNIESAALQNKLDHKCW--AVSVCFSPDGQRMATSAADGSIRV 425
DG V V++ + L A+SV SPDG R+A IR+
Sbjct: 1903 GEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRI 1953
Score = 62.5 bits (145), Expect = 3e-09
Identities = 62/251 (24%), Positives = 106/251 (42%), Gaps = 15/251 (5%)
Query: 55 AYSPDGKYIASGALDGIINIFDVAQGK---LVHTLEG-HAMSIRSLCFSPDSQLLLTGSD 110
++S DG +A+G D + +DV K L+H+ H + ++ D+ LL++ S
Sbjct: 2068 SFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN-LLISCSS 2126
Query: 111 DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF 170
DG + L+D G GH S V +VA + VS S D T++VWD ++ +
Sbjct: 2127 DGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRDGTLKVWDHQGVELT-SI 2183
Query: 171 KEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
H+ + E + + S+ +VT GLD ++W + HTL G
Sbjct: 2184 PAHSGPISHCAAAMEPR-----AAGQPGSELLVVTVGLDGATRLW--HPLLVCQTHTLLG 2236
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H PV + AVS + I S+ + + ++PDGS
Sbjct: 2237 HSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAV 2296
Query: 291 TGGHTGKVTVY 301
+G G++ ++
Sbjct: 2297 SGNQAGELILW 2307
Score = 50.0 bits (114), Expect = 2e-05
Identities = 63/284 (22%), Positives = 103/284 (36%), Gaps = 35/284 (12%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSG----HASWVLSVAFS 141
L GH + FS D L TG D + +DV + H WV A++
Sbjct: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWT 2116
Query: 142 PDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKD 201
D +S S+D +V +WD +S Q F H V V A ++SVS D
Sbjct: 2117 KDNL-LISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA--AVEEHVVSVSRD------ 2167
Query: 202 YIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD----GETIAXXXXXXXXX 257
+KVW ++ +L ++ H P+ A + + G+ +
Sbjct: 2168 --------GTLKVWDHQGVELT---SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGL 2216
Query: 258 XXXXXXGQKIREIQTD-----SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVL 312
+ QT S + S + T G V ++ + D +
Sbjct: 2217 DGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCI 2276
Query: 313 DTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ +VAW+PDG SG + G + L+ + K + T +A
Sbjct: 2277 PRSSAAVTAVAWAPDGSMAVSGNQAGELILW--QEAKAVATAQA 2318
Score = 48.8 bits (111), Expect = 4e-05
Identities = 56/204 (27%), Positives = 89/204 (43%), Gaps = 17/204 (8%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAY-SPDGKYIA 64
L+ ++ SPDG V G A I I+ + SG Q ++A+ SP K +
Sbjct: 1927 LSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSP--KVLV 1984
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD---VVH 121
SGA DG + + + + L L + +LL + S+D ++L+ +
Sbjct: 1985 SGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTR 2044
Query: 122 ANLA-----GT-LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQ---HTFKE 172
+ A GT L GH V +FS DG +G DR++ WD+ + + H+F
Sbjct: 2045 PHKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPA 2104
Query: 173 -HNDQVWGVKFNAESNKIISVSED 195
H D V G + + N +IS S D
Sbjct: 2105 CHRDWVTGCAW-TKDNLLISCSSD 2127
Score = 42.7 bits (96), Expect = 0.003
Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 5/127 (3%)
Query: 352 HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAV-SVCFSPD 410
HT+ H+ VR+ A S + L+ +AS DG V ++ + A + AV +V ++PD
Sbjct: 2232 HTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPD 2291
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
G MA S ++L +E + + T + HI G + +S D+ I+ ++
Sbjct: 2292 GS-MAVSGNQAG-ELILWQEAKAVATAQAPGHI--GALIWSSAHTFFVLSADEKISEWQV 2347
Query: 471 PIPPKSA 477
+ SA
Sbjct: 2348 KLRKGSA 2354
>X70476-1|CAA49900.1| 906|Homo sapiens subunit of coatomer complex
protein.
Length = 906
Score = 91.9 bits (218), Expect = 5e-18
Identities = 61/237 (25%), Positives = 106/237 (44%), Gaps = 16/237 (6%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++D P +++ G + ++ E+ + + + + ++ +GA
Sbjct: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA-NLAGT 127
D I +F+ + VH E H+ IR + P +LT SDD +KL+D + +
Sbjct: 78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQV 137
Query: 128 LSGHASWVLSVAFSP-DGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
GH +V+ + +P D +F S S DRT++VW L S T + H V + + +
Sbjct: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS-- 195
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD 243
G K Y+++G D LVK+W Y+N + TLEGH V + P+
Sbjct: 196 ----------GGDKPYLISGADDRLVKIWDYQNK--TCVQTLEGHAQNVSCASFHPE 240
Score = 77.0 bits (181), Expect = 1e-13
Identities = 44/159 (27%), Positives = 77/159 (48%), Gaps = 4/159 (2%)
Query: 42 QVLDTRGKFTLSVAYSP-DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-- 98
QV + + + + +P D AS +LD I ++ + TLEGH + + +
Sbjct: 136 QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS 195
Query: 99 SPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRV 158
D L++G+DD +K++D + TL GHA V +F P+ ++GS D TVR+
Sbjct: 196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRI 255
Query: 159 WDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKG 197
W + + + T ++VW V SN +++ D+G
Sbjct: 256 WHSSTYRLESTLNYGMERVWCVASLRGSNN-VALGYDEG 293
Score = 67.3 bits (157), Expect = 1e-10
Identities = 57/236 (24%), Positives = 107/236 (45%), Gaps = 7/236 (2%)
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
K+++VTG D ++V++Y N LE +H E H + +AV P I
Sbjct: 69 KNWVVTGADDMQIRVFNY--NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
Query: 260 XXXXGQKIREI-QTDSSDMWKIVFSP-DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
++ + + + +IV +P D +Q A+ + V+ + + + + L+ K
Sbjct: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEK 186
Query: 318 FIMSVAWSPDGR--YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
+ + + G Y+ SGA+ V ++D + T+E HAQ V +F P+ ++ +
Sbjct: 187 GVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIIT 246
Query: 376 ASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDG-QRMATSAADGSIRVVLLEE 430
S DG V +++ + L++ L++ V S G +A +GSI V L E
Sbjct: 247 GSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGRE 302
Score = 63.3 bits (147), Expect = 2e-09
Identities = 45/207 (21%), Positives = 90/207 (43%), Gaps = 18/207 (8%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV-AQ 79
V++G++ +I +F + ++ + + + +A P +I + + D +I ++D +
Sbjct: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK 131
Query: 80 GKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
EGH + + +P D+ + S D +K++ + ++ TL GH V +
Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191
Query: 139 AFSPDGKR--FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
+ G + +SG+ DR V++WD + C T + H V F+
Sbjct: 192 DYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFH------------- 238
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLE 223
P I+TG D V++W +LE
Sbjct: 239 -PELPIIITGSEDGTVRIWHSSTYRLE 264
Score = 61.3 bits (142), Expect = 7e-09
Identities = 57/300 (19%), Positives = 114/300 (38%), Gaps = 18/300 (6%)
Query: 44 LDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ 103
L R SV P ++ + +G + +++ LV T E + +R+ F
Sbjct: 11 LTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKN 70
Query: 104 LLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD- 162
++TG+DD +++++ H+ ++ +A P ++ S D +++WD D
Sbjct: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130
Query: 163 SMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKL 222
C F+ H V + N + N + + LD +KVW ++
Sbjct: 131 KWSCSQVFEGHTHYVMQIVINPKDN-------------NQFASASLDRTIKVWQLGSSSP 177
Query: 223 ELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK--IREIQTDSSDMWKI 280
TLEGHE V + G+ K ++ ++ + ++
Sbjct: 178 NF--TLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCA 235
Query: 281 VFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSV 340
F P+ + TG G V ++ ++ L+ + + VA +A G + GS+
Sbjct: 236 SFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI 295
Score = 51.2 bits (117), Expect = 8e-06
Identities = 39/207 (18%), Positives = 93/207 (44%), Gaps = 5/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R++ S + + P + + G V V+ T+ K + + + +
Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVAR 68
Query: 328 GRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI 387
++ +GA+ + +F+ + + +H EAH+ +R +A P + ++S+D + +++
Sbjct: 69 KNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDW 128
Query: 388 ES--AALQNKLDHKCWAVSVCFSP-DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIV 444
+ + Q H + + + +P D + A+++ D +I+V L T E H V
Sbjct: 129 DKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGV 188
Query: 445 CGVQFNADGSK--LVSVSKDKSINIYE 469
+ + + G K L+S + D+ + I++
Sbjct: 189 NCIDYYSGGDKPYLISGADDRLVKIWD 215
>BC000326-1|AAH00326.1| 906|Homo sapiens coatomer protein complex,
subunit beta 2 (beta prime) protein.
Length = 906
Score = 91.9 bits (218), Expect = 5e-18
Identities = 61/237 (25%), Positives = 106/237 (44%), Gaps = 16/237 (6%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V ++D P +++ G + ++ E+ + + + + ++ +GA
Sbjct: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA-NLAGT 127
D I +F+ + VH E H+ IR + P +LT SDD +KL+D + +
Sbjct: 78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQV 137
Query: 128 LSGHASWVLSVAFSP-DGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
GH +V+ + +P D +F S S DRT++VW L S T + H V + + +
Sbjct: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS-- 195
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD 243
G K Y+++G D LVK+W Y+N + TLEGH V + P+
Sbjct: 196 ----------GGDKPYLISGADDRLVKIWDYQNK--TCVQTLEGHAQNVSCASFHPE 240
Score = 77.0 bits (181), Expect = 1e-13
Identities = 44/159 (27%), Positives = 77/159 (48%), Gaps = 4/159 (2%)
Query: 42 QVLDTRGKFTLSVAYSP-DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-- 98
QV + + + + +P D AS +LD I ++ + TLEGH + + +
Sbjct: 136 QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS 195
Query: 99 SPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRV 158
D L++G+DD +K++D + TL GHA V +F P+ ++GS D TVR+
Sbjct: 196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRI 255
Query: 159 WDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKG 197
W + + + T ++VW V SN +++ D+G
Sbjct: 256 WHSSTYRLESTLNYGMERVWCVASLRGSNN-VALGYDEG 293
Score = 67.3 bits (157), Expect = 1e-10
Identities = 57/236 (24%), Positives = 107/236 (45%), Gaps = 7/236 (2%)
Query: 200 KDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX 259
K+++VTG D ++V++Y N LE +H E H + +AV P I
Sbjct: 69 KNWVVTGADDMQIRVFNY--NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
Query: 260 XXXXGQKIREI-QTDSSDMWKIVFSP-DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
++ + + + +IV +P D +Q A+ + V+ + + + + L+ K
Sbjct: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEK 186
Query: 318 FIMSVAWSPDGR--YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
+ + + G Y+ SGA+ V ++D + T+E HAQ V +F P+ ++ +
Sbjct: 187 GVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIIT 246
Query: 376 ASNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDG-QRMATSAADGSIRVVLLEE 430
S DG V +++ + L++ L++ V S G +A +GSI V L E
Sbjct: 247 GSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGRE 302
Score = 63.3 bits (147), Expect = 2e-09
Identities = 45/207 (21%), Positives = 90/207 (43%), Gaps = 18/207 (8%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDV-AQ 79
V++G++ +I +F + ++ + + + +A P +I + + D +I ++D +
Sbjct: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK 131
Query: 80 GKLVHTLEGHAMSIRSLCFSP-DSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSV 138
EGH + + +P D+ + S D +K++ + ++ TL GH V +
Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191
Query: 139 AFSPDGKR--FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDK 196
+ G + +SG+ DR V++WD + C T + H V F+
Sbjct: 192 DYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFH------------- 238
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLE 223
P I+TG D V++W +LE
Sbjct: 239 -PELPIIITGSEDGTVRIWHSSTYRLE 264
Score = 61.3 bits (142), Expect = 7e-09
Identities = 57/300 (19%), Positives = 114/300 (38%), Gaps = 18/300 (6%)
Query: 44 LDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ 103
L R SV P ++ + +G + +++ LV T E + +R+ F
Sbjct: 11 LTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKN 70
Query: 104 LLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD- 162
++TG+DD +++++ H+ ++ +A P ++ S D +++WD D
Sbjct: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130
Query: 163 SMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKL 222
C F+ H V + N + N + + LD +KVW ++
Sbjct: 131 KWSCSQVFEGHTHYVMQIVINPKDN-------------NQFASASLDRTIKVWQLGSSSP 177
Query: 223 ELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQK--IREIQTDSSDMWKI 280
TLEGHE V + G+ K ++ ++ + ++
Sbjct: 178 NF--TLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCA 235
Query: 281 VFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSV 340
F P+ + TG G V ++ ++ L+ + + VA +A G + GS+
Sbjct: 236 SFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI 295
Score = 51.2 bits (117), Expect = 8e-06
Identities = 39/207 (18%), Positives = 93/207 (44%), Gaps = 5/207 (2%)
Query: 268 REIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD 327
R++ S + + P + + G V V+ T+ K + + + +
Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVAR 68
Query: 328 GRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI 387
++ +GA+ + +F+ + + +H EAH+ +R +A P + ++S+D + +++
Sbjct: 69 KNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDW 128
Query: 388 ES--AALQNKLDHKCWAVSVCFSP-DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIV 444
+ + Q H + + + +P D + A+++ D +I+V L T E H V
Sbjct: 129 DKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGV 188
Query: 445 CGVQFNADGSK--LVSVSKDKSINIYE 469
+ + + G K L+S + D+ + I++
Sbjct: 189 NCIDYYSGGDKPYLISGADDRLVKIWD 215
>AK123876-1|BAC85713.1| 428|Homo sapiens protein ( Homo sapiens
cDNA FLJ41882 fis, clone OCBBF2022351, weakly similar
to TIPD PROTEIN. ).
Length = 428
Score = 91.1 bits (216), Expect = 8e-18
Identities = 75/276 (27%), Positives = 125/276 (45%), Gaps = 29/276 (10%)
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHAS 133
+FD G+ V+ ++ + I S+ F LL S+D +++ V L TL+GH+
Sbjct: 173 VFDAHDGE-VNAVQ-FSPGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSG 230
Query: 134 WVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
VLS F D R VSGS DRT+++WDL S C T V + N I+
Sbjct: 231 KVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKT----------VFAGSSCNDIVC-- 278
Query: 194 EDKGPSKDYIVTGGLDNLVKVWSYEN----NKLELLHTLEGHEM-PVVSVAVSPDGETIA 248
++ +++G D ++ W + ++ELL + ++ P + +S + +
Sbjct: 279 -----TEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLL 333
Query: 249 XXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTV 308
+ SD ++VFSPDGS VA G G + ++ ++ G V
Sbjct: 334 KVIDLRTNAIKQTFSAPGFK----CGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKV 389
Query: 309 DKVLDTR-GKFIMSVAWSPDGRYIASGAEGGSVYLF 343
+KVL + I +VAWSP G ++ S +G L+
Sbjct: 390 EKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 425
Score = 56.4 bits (130), Expect = 2e-07
Identities = 62/269 (23%), Positives = 110/269 (40%), Gaps = 25/269 (9%)
Query: 27 AGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTL 86
A + +F G+ V + G S+ + G Y+ + + D I+ V +L HTL
Sbjct: 168 ATALCVFDAHDGEVNAVQFSPG--ITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTL 225
Query: 87 EGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKR 146
GH+ + S F D+ +++GS D +KL+D+ T+ +S V +
Sbjct: 226 TGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QC 282
Query: 147 FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTG 206
+SG D+ +R WD+ S E ++ + N E +++S S
Sbjct: 283 VMSGHFDKKIRFWDIRSESIVREM-ELLGKITALDLNPERTELLSCSR------------ 329
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHE--MPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
D+L+KV N ++ + G + V SPDG +A G
Sbjct: 330 --DDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTG 387
Query: 265 QKIREI--QTDSSDMWKIVFSPDGSQVAT 291
K+ ++ + SS + + +SP GS V +
Sbjct: 388 -KVEKVLSKQHSSSINAVAWSPSGSHVVS 415
Score = 47.2 bits (107), Expect = 1e-04
Identities = 24/58 (41%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 10 WT-LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTL-SVAYSPDGKYIAS 65
WT + FSPDG +V +GS G + I+ V +GK E+VL + ++ +VA+SP G ++ S
Sbjct: 358 WTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVS 415
Score = 44.0 bits (99), Expect = 0.001
Identities = 46/239 (19%), Positives = 98/239 (41%), Gaps = 25/239 (10%)
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
+ S+ F G ++ S D R+W +D + +HT H S K++S
Sbjct: 190 ITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGH------------SGKVLSAKF 237
Query: 195 DKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXX 254
++ IV+G D +K+W + K+ + G + + +
Sbjct: 238 LLDNAR--IVSGSHDRTLKLWDLRS-KVCIKTVFAGSSCNDIVCTE----QCVMSGHFDK 290
Query: 255 XXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDT 314
+RE++ + + +P+ +++ + + V + + +
Sbjct: 291 KIRFWDIRSESIVREMEL-LGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSA 349
Query: 315 RGKFIMS----VAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI-EAHAQAVRSLAFSP 368
G S V +SPDG Y+A+G+ GS+Y++ V GK+ + + H+ ++ ++A+SP
Sbjct: 350 PGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSP 408
Score = 44.0 bits (99), Expect = 0.001
Identities = 33/137 (24%), Positives = 66/137 (48%), Gaps = 7/137 (5%)
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA 390
+ SG + +D+ ++ +E + + +L +P+ L S S D + V ++ +
Sbjct: 283 VMSGHFDKKIRFWDIRSESIVREMELLGK-ITALDLNPERTELLSCSRDDLLKVIDLRTN 341
Query: 391 ALQNKLD---HKCWA--VSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTF-EEHTHIV 444
A++ KC + V FSPDG +A +A+GS+ + + +V ++H+ +
Sbjct: 342 AIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSI 401
Query: 445 CGVQFNADGSKLVSVSK 461
V ++ GS +VSV K
Sbjct: 402 NAVAWSPSGSHVVSVDK 418
Score = 31.5 bits (68), Expect = 6.8
Identities = 20/90 (22%), Positives = 43/90 (47%), Gaps = 2/90 (2%)
Query: 300 VYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ 359
V+ +G V+ V + G I S+ + G Y+ + + + ++ V ++ HT+ H+
Sbjct: 173 VFDAHDGEVNAVQFSPG--ITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSG 230
Query: 360 AVRSLAFSPKTKLLASASNDGYVNVYNIES 389
V S F + S S+D + ++++ S
Sbjct: 231 KVLSAKFLLDNARIVSGSHDRTLKLWDLRS 260
>X95263-1|CAA64560.1| 919|Homo sapiens PWP2 protein.
Length = 919
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/325 (25%), Positives = 139/325 (42%), Gaps = 37/325 (11%)
Query: 53 SVAYSPDGKYIASGALD-GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDD 111
SVA + G +IA G G + +++ V +GH S+ +L +SPD Q ++TG DD
Sbjct: 335 SVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDD 394
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
G +K+++ + T + H+S V V F+ G V+ S D TVR +DL + TF
Sbjct: 395 GKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNL-VKVWSYENNKLELLHTLEG 230
+ + V+ D S + + G D+ + VWS + + LL L G
Sbjct: 455 -----------SPRPTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGR--LLDVLSG 499
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
HE P+ + +P +A + +E +SD + F PDG+++A
Sbjct: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELA 559
Query: 291 TGGHTGKVTVY--------GIINGTVD-----KVLD-------TRGKFIMSVAWSPDGRY 330
++T + G I G D K LD +GK ++ +S DG
Sbjct: 560 VATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHS 619
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIE 355
I +G V ++ V + ++ E
Sbjct: 620 ILAGGMSKFVCIYHVREQILMKRFE 644
Score = 78.2 bits (184), Expect = 6e-14
Identities = 99/479 (20%), Positives = 203/479 (42%), Gaps = 24/479 (5%)
Query: 9 VWTLDFSPDG-KHVISGSNAGKILIF-GVESGKQEQVLDTR--GKF--TLSVAYSPDGKY 62
V ++ FSPDG K V++ N ++ G + VLD G + T + ++ D +
Sbjct: 99 VHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRC 158
Query: 63 IASGALDGIINIFDVAQ--GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
G+ D +F + + + L GH +I + F +S L + S DG + ++
Sbjct: 159 FVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCD 218
Query: 121 HANLAGTLSGHASW---VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
L A W +L + + G + T+R + + + T K ++
Sbjct: 219 TPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEE-EKTGKVKYSRL 277
Query: 178 WGVKFNAES--NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPV 235
FN E N + + + K +VTG + + +E + L+H+L + +
Sbjct: 278 AKYFFNKEGDFNNLTAAAFHK--KSHLLVTGFASGIFHL--HELPEFNLIHSLSISDQSI 333
Query: 236 VSVAVSPDGETIAXXXXXXXXXXXXXXXGQK-IREIQTDSSDMWKIVFSPDGSQVATGGH 294
SVA++ G+ IA + + + Q + M + +SPDG + TGG
Sbjct: 334 ASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGD 393
Query: 295 TGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI 354
GKV V+ ++G + V ++ G + + + G+V FD+ + + T
Sbjct: 394 DGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTF 453
Query: 355 EAHAQAVRS-LAFSPKTKLLASASNDGY-VNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
+ S +A +++++ + D + + V+++++ L + L H+ +CF+P
Sbjct: 454 TSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
Query: 412 QRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+A+++ D ++R+ + + +R T T V F DG++L + + I ++
Sbjct: 514 SVLASASWDKTVRLWDMFDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWD 571
Score = 37.1 bits (82), Expect = 0.14
Identities = 43/193 (22%), Positives = 80/193 (41%), Gaps = 14/193 (7%)
Query: 297 KVTVYGIINGTVDKV-LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+VTV+ + N D + L TR + V SPDGR EGG L + +LH
Sbjct: 36 RVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFH 94
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE------SAALQNKLDHKCWAVSVC--F 407
+V S++FSP + + +Y+ +A + +K + + C +
Sbjct: 95 FKG-SVHSVSFSPDGRKFV-VTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDW 152
Query: 408 SPDGQRMATSAADGSIRVVLLEEF--RVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSI 465
+ D + + D S V E + + + H + F ++ L S+S+D +
Sbjct: 153 TDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVL 212
Query: 466 NIYECPIPPKSAK 478
+++C PP+ +
Sbjct: 213 CMWQCDTPPEGLR 225
>U56089-1|AAC50905.1| 919|Homo sapiens periodic tryptophan protein
2 protein.
Length = 919
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/325 (25%), Positives = 139/325 (42%), Gaps = 37/325 (11%)
Query: 53 SVAYSPDGKYIASGALD-GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDD 111
SVA + G +IA G G + +++ V +GH S+ +L +SPD Q ++TG DD
Sbjct: 335 SVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDD 394
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
G +K+++ + T + H+S V V F+ G V+ S D TVR +DL + TF
Sbjct: 395 GKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNL-VKVWSYENNKLELLHTLEG 230
+ + V+ D S + + G D+ + VWS + + LL L G
Sbjct: 455 -----------SPRPTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGR--LLDVLSG 499
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
HE P+ + +P +A + +E +SD + F PDG+++A
Sbjct: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELA 559
Query: 291 TGGHTGKVTVY--------GIINGTVD-----KVLD-------TRGKFIMSVAWSPDGRY 330
++T + G I G D K LD +GK ++ +S DG
Sbjct: 560 VATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHS 619
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIE 355
I +G V ++ V + ++ E
Sbjct: 620 ILAGGMSKFVCIYHVREQILMKRFE 644
Score = 78.2 bits (184), Expect = 6e-14
Identities = 99/479 (20%), Positives = 203/479 (42%), Gaps = 24/479 (5%)
Query: 9 VWTLDFSPDG-KHVISGSNAGKILIF-GVESGKQEQVLDTR--GKF--TLSVAYSPDGKY 62
V ++ FSPDG K V++ N ++ G + VLD G + T + ++ D +
Sbjct: 99 VHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRC 158
Query: 63 IASGALDGIINIFDVAQ--GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
G+ D +F + + + L GH +I + F +S L + S DG + ++
Sbjct: 159 FVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCD 218
Query: 121 HANLAGTLSGHASW---VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
L A W +L + + G + T+R + + + T K ++
Sbjct: 219 TPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEE-EKTGKVKYSRL 277
Query: 178 WGVKFNAES--NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPV 235
FN E N + + + K +VTG + + +E + L+H+L + +
Sbjct: 278 AKYFFNKEGDFNNLTAAAFHK--KSHLLVTGFASGIFHL--HELPEFNLIHSLSISDQSI 333
Query: 236 VSVAVSPDGETIAXXXXXXXXXXXXXXXGQK-IREIQTDSSDMWKIVFSPDGSQVATGGH 294
SVA++ G+ IA + + + Q + M + +SPDG + TGG
Sbjct: 334 ASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGD 393
Query: 295 TGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI 354
GKV V+ ++G + V ++ G + + + G+V FD+ + + T
Sbjct: 394 DGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTF 453
Query: 355 EAHAQAVRS-LAFSPKTKLLASASNDGY-VNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
+ S +A +++++ + D + + V+++++ L + L H+ +CF+P
Sbjct: 454 TSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
Query: 412 QRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+A+++ D ++R+ + + +R T T V F DG++L + + I ++
Sbjct: 514 SVLASASWDKTVRLWDMFDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWD 571
Score = 37.1 bits (82), Expect = 0.14
Identities = 43/193 (22%), Positives = 80/193 (41%), Gaps = 14/193 (7%)
Query: 297 KVTVYGIINGTVDKV-LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+VTV+ + N D + L TR + V SPDGR EGG L + +LH
Sbjct: 36 RVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFH 94
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE------SAALQNKLDHKCWAVSVC--F 407
+V S++FSP + + +Y+ +A + +K + + C +
Sbjct: 95 FKG-SVHSVSFSPDGRKFV-VTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDW 152
Query: 408 SPDGQRMATSAADGSIRVVLLEEF--RVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSI 465
+ D + + D S V E + + + H + F ++ L S+S+D +
Sbjct: 153 TDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVL 212
Query: 466 NIYECPIPPKSAK 478
+++C PP+ +
Sbjct: 213 CMWQCDTPPEGLR 225
>U56085-1|AAC50904.1| 919|Homo sapiens periodic tryptophan protein
2 protein.
Length = 919
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/325 (25%), Positives = 139/325 (42%), Gaps = 37/325 (11%)
Query: 53 SVAYSPDGKYIASGALD-GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDD 111
SVA + G +IA G G + +++ V +GH S+ +L +SPD Q ++TG DD
Sbjct: 335 SVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDD 394
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
G +K+++ + T + H+S V V F+ G V+ S D TVR +DL + TF
Sbjct: 395 GKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNL-VKVWSYENNKLELLHTLEG 230
+ + V+ D S + + G D+ + VWS + + LL L G
Sbjct: 455 -----------SPRPTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGR--LLDVLSG 499
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
HE P+ + +P +A + +E +SD + F PDG+++A
Sbjct: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELA 559
Query: 291 TGGHTGKVTVY--------GIINGTVD-----KVLD-------TRGKFIMSVAWSPDGRY 330
++T + G I G D K LD +GK ++ +S DG
Sbjct: 560 VATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHS 619
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIE 355
I +G V ++ V + ++ E
Sbjct: 620 ILAGGMSKFVCIYHVREQILMKRFE 644
Score = 78.2 bits (184), Expect = 6e-14
Identities = 99/479 (20%), Positives = 203/479 (42%), Gaps = 24/479 (5%)
Query: 9 VWTLDFSPDG-KHVISGSNAGKILIF-GVESGKQEQVLDTR--GKF--TLSVAYSPDGKY 62
V ++ FSPDG K V++ N ++ G + VLD G + T + ++ D +
Sbjct: 99 VHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRC 158
Query: 63 IASGALDGIINIFDVAQ--GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
G+ D +F + + + L GH +I + F +S L + S DG + ++
Sbjct: 159 FVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCD 218
Query: 121 HANLAGTLSGHASW---VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
L A W +L + + G + T+R + + + T K ++
Sbjct: 219 TPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEE-EKTGKVKYSRL 277
Query: 178 WGVKFNAES--NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPV 235
FN E N + + + K +VTG + + +E + L+H+L + +
Sbjct: 278 AKYFFNKEGDFNNLTAAAFHK--KSHLLVTGFASGIFHL--HELPEFNLIHSLSISDQSI 333
Query: 236 VSVAVSPDGETIAXXXXXXXXXXXXXXXGQK-IREIQTDSSDMWKIVFSPDGSQVATGGH 294
SVA++ G+ IA + + + Q + M + +SPDG + TGG
Sbjct: 334 ASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGD 393
Query: 295 TGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI 354
GKV V+ ++G + V ++ G + + + G+V FD+ + + T
Sbjct: 394 DGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTF 453
Query: 355 EAHAQAVRS-LAFSPKTKLLASASNDGY-VNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
+ S +A +++++ + D + + V+++++ L + L H+ +CF+P
Sbjct: 454 TSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
Query: 412 QRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+A+++ D ++R+ + + +R T T V F DG++L + + I ++
Sbjct: 514 SVLASASWDKTVRLWDMFDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWD 571
Score = 37.1 bits (82), Expect = 0.14
Identities = 43/193 (22%), Positives = 80/193 (41%), Gaps = 14/193 (7%)
Query: 297 KVTVYGIINGTVDKV-LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+VTV+ + N D + L TR + V SPDGR EGG L + +LH
Sbjct: 36 RVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFH 94
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE------SAALQNKLDHKCWAVSVC--F 407
+V S++FSP + + +Y+ +A + +K + + C +
Sbjct: 95 FKG-SVHSVSFSPDGRKFV-VTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDW 152
Query: 408 SPDGQRMATSAADGSIRVVLLEEF--RVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSI 465
+ D + + D S V E + + + H + F ++ L S+S+D +
Sbjct: 153 TDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVL 212
Query: 466 NIYECPIPPKSAK 478
+++C PP+ +
Sbjct: 213 CMWQCDTPPEGLR 225
>U53346-1|AAB08084.1| 919|Homo sapiens PWP2H protein protein.
Length = 919
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/325 (25%), Positives = 139/325 (42%), Gaps = 37/325 (11%)
Query: 53 SVAYSPDGKYIASGALD-GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDD 111
SVA + G +IA G G + +++ V +GH S+ +L +SPD Q ++TG DD
Sbjct: 335 SVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDD 394
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
G +K+++ + T + H+S V V F+ G V+ S D TVR +DL + TF
Sbjct: 395 GKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNL-VKVWSYENNKLELLHTLEG 230
+ + V+ D S + + G D+ + VWS + + LL L G
Sbjct: 455 -----------SPRPTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGR--LLDVLSG 499
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
HE P+ + +P +A + +E +SD + F PDG+++A
Sbjct: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELA 559
Query: 291 TGGHTGKVTVY--------GIINGTVD-----KVLD-------TRGKFIMSVAWSPDGRY 330
++T + G I G D K LD +GK ++ +S DG
Sbjct: 560 VATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHS 619
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIE 355
I +G V ++ V + ++ E
Sbjct: 620 ILAGGMSKFVCIYHVREQILMKRFE 644
Score = 78.2 bits (184), Expect = 6e-14
Identities = 99/479 (20%), Positives = 203/479 (42%), Gaps = 24/479 (5%)
Query: 9 VWTLDFSPDG-KHVISGSNAGKILIF-GVESGKQEQVLDTR--GKF--TLSVAYSPDGKY 62
V ++ FSPDG K V++ N ++ G + VLD G + T + ++ D +
Sbjct: 99 VHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRC 158
Query: 63 IASGALDGIINIFDVAQ--GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
G+ D +F + + + L GH +I + F +S L + S DG + ++
Sbjct: 159 FVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCD 218
Query: 121 HANLAGTLSGHASW---VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
L A W +L + + G + T+R + + + T K ++
Sbjct: 219 TPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEE-EKTGKVKYSRL 277
Query: 178 WGVKFNAES--NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPV 235
FN E N + + + K +VTG + + +E + L+H+L + +
Sbjct: 278 AKYFFNKEGDFNNLTAAAFHK--KSHLLVTGFASGIFHL--HELPEFNLIHSLSISDQSI 333
Query: 236 VSVAVSPDGETIAXXXXXXXXXXXXXXXGQK-IREIQTDSSDMWKIVFSPDGSQVATGGH 294
SVA++ G+ IA + + + Q + M + +SPDG + TGG
Sbjct: 334 ASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGD 393
Query: 295 TGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI 354
GKV V+ ++G + V ++ G + + + G+V FD+ + + T
Sbjct: 394 DGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTF 453
Query: 355 EAHAQAVRS-LAFSPKTKLLASASNDGY-VNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
+ S +A +++++ + D + + V+++++ L + L H+ +CF+P
Sbjct: 454 TSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
Query: 412 QRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+A+++ D ++R+ + + +R T T V F DG++L + + I ++
Sbjct: 514 SVLASASWDKTVRLWDMFDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWD 571
Score = 37.1 bits (82), Expect = 0.14
Identities = 43/193 (22%), Positives = 80/193 (41%), Gaps = 14/193 (7%)
Query: 297 KVTVYGIINGTVDKV-LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+VTV+ + N D + L TR + V SPDGR EGG L + +LH
Sbjct: 36 RVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFH 94
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE------SAALQNKLDHKCWAVSVC--F 407
+V S++FSP + + +Y+ +A + +K + + C +
Sbjct: 95 FKG-SVHSVSFSPDGRKFV-VTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDW 152
Query: 408 SPDGQRMATSAADGSIRVVLLEEF--RVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSI 465
+ D + + D S V E + + + H + F ++ L S+S+D +
Sbjct: 153 TDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVL 212
Query: 466 NIYECPIPPKSAK 478
+++C PP+ +
Sbjct: 213 CMWQCDTPPEGLR 225
>AP001753-1|BAA95553.1| 919|Homo sapiens periodic tryptophan
protein 2 homolog protein.
Length = 919
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/325 (25%), Positives = 139/325 (42%), Gaps = 37/325 (11%)
Query: 53 SVAYSPDGKYIASGALD-GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDD 111
SVA + G +IA G G + +++ V +GH S+ +L +SPD Q ++TG DD
Sbjct: 335 SVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDD 394
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
G +K+++ + T + H+S V V F+ G V+ S D TVR +DL + TF
Sbjct: 395 GKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNL-VKVWSYENNKLELLHTLEG 230
+ + V+ D S + + G D+ + VWS + + LL L G
Sbjct: 455 -----------SPRPTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGR--LLDVLSG 499
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
HE P+ + +P +A + +E +SD + F PDG+++A
Sbjct: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELA 559
Query: 291 TGGHTGKVTVY--------GIINGTVD-----KVLD-------TRGKFIMSVAWSPDGRY 330
++T + G I G D K LD +GK ++ +S DG
Sbjct: 560 VATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHS 619
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIE 355
I +G V ++ V + ++ E
Sbjct: 620 ILAGGMSKFVCIYHVREQILMKRFE 644
Score = 78.2 bits (184), Expect = 6e-14
Identities = 99/479 (20%), Positives = 203/479 (42%), Gaps = 24/479 (5%)
Query: 9 VWTLDFSPDG-KHVISGSNAGKILIF-GVESGKQEQVLDTR--GKF--TLSVAYSPDGKY 62
V ++ FSPDG K V++ N ++ G + VLD G + T + ++ D +
Sbjct: 99 VHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRC 158
Query: 63 IASGALDGIINIFDVAQ--GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
G+ D +F + + + L GH +I + F +S L + S DG + ++
Sbjct: 159 FVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCD 218
Query: 121 HANLAGTLSGHASW---VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
L A W +L + + G + T+R + + + T K ++
Sbjct: 219 TPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEE-EKTGKVKYSRL 277
Query: 178 WGVKFNAES--NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPV 235
FN E N + + + K +VTG + + +E + L+H+L + +
Sbjct: 278 AKYFFNKEGDFNNLTAAAFHK--KSHLLVTGFASGIFHL--HELPEFNLIHSLSISDQSI 333
Query: 236 VSVAVSPDGETIAXXXXXXXXXXXXXXXGQK-IREIQTDSSDMWKIVFSPDGSQVATGGH 294
SVA++ G+ IA + + + Q + M + +SPDG + TGG
Sbjct: 334 ASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGD 393
Query: 295 TGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI 354
GKV V+ ++G + V ++ G + + + G+V FD+ + + T
Sbjct: 394 DGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTF 453
Query: 355 EAHAQAVRS-LAFSPKTKLLASASNDGY-VNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
+ S +A +++++ + D + + V+++++ L + L H+ +CF+P
Sbjct: 454 TSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
Query: 412 QRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+A+++ D ++R+ + + +R T T V F DG++L + + I ++
Sbjct: 514 SVLASASWDKTVRLWDMFDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWD 571
Score = 38.3 bits (85), Expect = 0.059
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 15/208 (7%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKV-LDTRGKFIMSVAWSPDGRYIASGAEGGSV 340
F+ DG+ V + +VTV+ + N D + L TR + V SPDGR EGG
Sbjct: 22 FTCDGNSVISPVGN-RVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGGDA 79
Query: 341 YLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE------SAALQN 394
L + +LH +V S++FSP + + +Y+ +A + +
Sbjct: 80 LLVSLVCRSVLHHFHFKG-SVHSVSFSPDGRKFV-VTKGNIAQMYHAPGKKREFNAFVLD 137
Query: 395 KLDHKCWAVSVC--FSPDGQRMATSAADGSIRVVLLEEF--RVLHTFEEHTHIVCGVQFN 450
K + + C ++ D + + D S V E + + + H + F
Sbjct: 138 KTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFE 197
Query: 451 ADGSKLVSVSKDKSINIYECPIPPKSAK 478
++ L S+S+D + +++C PP+ +
Sbjct: 198 SNSLDLYSLSQDGVLCMWQCDTPPEGLR 225
>AL121993-4|CAI22739.1| 943|Homo sapiens WD repeat domain 3
protein.
Length = 943
Score = 89.8 bits (213), Expect = 2e-17
Identities = 75/335 (22%), Positives = 150/335 (44%), Gaps = 16/335 (4%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC--FSPDSQLLLTGSD 110
++++S D + S A D I I++ + + + T+ +LC F P + ++ G+
Sbjct: 420 TLSFSSDNIAVLSAAADSI-KIWNRSTLQCIRTMTCEY----ALCSFFVPGDRQVVIGTK 474
Query: 111 DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF 170
G ++LYD+ NL T+ H + S++ SPD + FV+G AD++V+ WD + ++ +++
Sbjct: 475 TGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENST 534
Query: 171 KEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
++ V + ++ VS P++ + LD VK++ + K L +L G
Sbjct: 535 QKRL-SVKQTRTLQLDEDVLCVS--YSPNQKLLAVSLLDCTVKIFYVDTLKFFL--SLYG 589
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H++PV+ + +S DG IA G + + + + F P
Sbjct: 590 HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFF 649
Query: 291 TGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM 350
T G K+ + + L+ + I +A SP G Y+ S + S+ L++ ++ +
Sbjct: 650 TAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPL 709
Query: 351 L----HTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+ +E A+ S+A + + D Y
Sbjct: 710 ILEEEREMEREAEYEESVAKEDQPAVPGETQGDSY 744
Score = 84.6 bits (200), Expect = 7e-16
Identities = 52/199 (26%), Positives = 92/199 (46%), Gaps = 11/199 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQ-------VLDTR----GKFTLSVAYS 57
+W++ SPD + ++G + + E K E V TR + L V+YS
Sbjct: 499 LWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYS 558
Query: 58 PDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
P+ K +A LD + IF V K +L GH + + + S D L+ TGS D ++K++
Sbjct: 559 PNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIW 618
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
+ + +L H V+ + F P F + D ++ WD D + T + H+ ++
Sbjct: 619 GLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEI 678
Query: 178 WGVKFNAESNKIISVSEDK 196
W + + + ++S S DK
Sbjct: 679 WCLAVSPSGDYVVSSSHDK 697
Score = 84.2 bits (199), Expect = 9e-16
Identities = 46/166 (27%), Positives = 80/166 (48%)
Query: 30 ILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGH 89
+ I+ + G++ +L + + SPDG ++A G DG I IF + G+ T GH
Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
Query: 90 AMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVS 149
+I +L + L +GS D + ++DV++ + L GH + F + V+
Sbjct: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
Query: 150 GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
D V+ WDLD+ C T H +VWG+ +E ++I+ + D
Sbjct: 167 SGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASD 212
Score = 79.8 bits (188), Expect = 2e-14
Identities = 45/151 (29%), Positives = 76/151 (50%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SPDG H+ G G I IF + SG+ + ++ Y G +ASG+ D I +
Sbjct: 74 SPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIV 133
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
+DV ++ L+GH +I F + LL+T D +K +D+ + T+ GH +
Sbjct: 134 WDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTE 193
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ 165
V + + KR ++G++D +RVWD+ +Q
Sbjct: 194 VWGLVLLSEEKRLITGASDSELRVWDIAYLQ 224
Score = 73.7 bits (173), Expect = 1e-12
Identities = 48/189 (25%), Positives = 82/189 (43%), Gaps = 17/189 (8%)
Query: 47 RGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLL 106
+G G+Y+A A + + I+D+ +G+ + L+G + LC SPD L
Sbjct: 23 KGNIVFVTLRGEKGRYVAVPACEHVF-IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLA 81
Query: 107 TGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQC 166
G +DG ++++ ++ T +GH + + ++ + G R SGS D + VWD+ +
Sbjct: 82 VGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESG 141
Query: 167 QHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLH 226
+ K H D + F E N +VT G D +VK W +
Sbjct: 142 LYRLKGHKDAITQALFLREKN--------------LLVTSGKDTMVKWWDLDTQ--HCFK 185
Query: 227 TLEGHEMPV 235
T+ GH V
Sbjct: 186 TMVGHRTEV 194
Score = 68.5 bits (160), Expect = 5e-11
Identities = 68/281 (24%), Positives = 121/281 (43%), Gaps = 46/281 (16%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASG 66
+DV TL FS D V+S + A I I+ + + + + ++ L + P + + G
Sbjct: 416 SDVRTLSFSSDNIAVLSAA-ADSIKIWNRSTLQCIRTMTC--EYALCSFFVPGDRQVVIG 472
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
G + ++D+A G L+ T++ H ++ S+ SPD + +TG D +K +D
Sbjct: 473 TKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDEN 532
Query: 127 TLSGHASW-----------VLSVAFSPDGKRFVSGSADRTVRVWDLDS------------ 163
+ S VL V++SP+ K D TV+++ +D+
Sbjct: 533 STQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKL 592
Query: 164 ----MQCQHT-------FKEHNDQVWGVKFNAESNKIISVSEDK------GPSKDYIVTG 206
M H + N ++WG+ F + +K + +D P T
Sbjct: 593 PVICMDISHDGALIATGSADRNVKIWGLDF-GDCHKSLFAHDDSVMYLQFVPKSHLFFTA 651
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
G D+ +K W + +K E + TLEGH + +AVSP G+ +
Sbjct: 652 GKDHKIKQW--DADKFEHIQTLEGHHQEIWCLAVSPSGDYV 690
Score = 62.9 bits (146), Expect = 2e-09
Identities = 45/153 (29%), Positives = 70/153 (45%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV + +SP+ K + + IF V++ K L + + S DG IA+G+
Sbjct: 551 DVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGS 610
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
D + I+ + G +L H S+ L F P S L T D +K +D T
Sbjct: 611 ADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQT 670
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
L GH + +A SP G VS S D+++R+W+
Sbjct: 671 LEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 60.5 bits (140), Expect = 1e-08
Identities = 34/163 (20%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
G+KI +Q ++ + SPDG +A G G + ++ +++G + + I ++
Sbjct: 55 GEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLK 114
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
+ G +ASG++ + ++DV L+ ++ H A+ F + LL ++ D V
Sbjct: 115 YDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVK 174
Query: 384 VYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+++++ + + H+ + + +R+ T A+D +RV
Sbjct: 175 WWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRV 217
Score = 58.8 bits (136), Expect = 4e-08
Identities = 67/289 (23%), Positives = 118/289 (40%), Gaps = 38/289 (13%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT---------FKEHNDQ- 176
T+ GH S V +++FS D +S +AD ++++W+ ++QC T F D+
Sbjct: 410 TIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQ 468
Query: 177 -VWGVKFN-------AESNKIISVSEDKG--------PSKDYIVTGGLDNLVKVWSYENN 220
V G K A N + ++ G P + VTGG D VK W +E
Sbjct: 469 VVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELV 528
Query: 221 K----------LELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREI 270
K ++ TL+ E V+ V+ SP+ + +A + +
Sbjct: 529 KDENSTQKRLSVKQTRTLQLDE-DVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSL 587
Query: 271 QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRY 330
+ + S DG+ +ATG V ++G+ G K L +M + + P
Sbjct: 588 YGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHL 647
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASND 379
+ + + +D + + + T+E H Q + LA SP + S+S+D
Sbjct: 648 FFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHD 696
Score = 54.0 bits (124), Expect = 1e-06
Identities = 40/206 (19%), Positives = 91/206 (44%), Gaps = 15/206 (7%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
SD+ + FS D V + + ++ T+ + ++ + + P R + G
Sbjct: 416 SDVRTLSFSSDNIAVLSAA-ADSIKIWN--RSTLQCIRTMTCEYALCSFFVPGDRQVVIG 472
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQN 394
+ G + L+D++ G +L TI+AH A+ S++ SP + + D V ++ E +N
Sbjct: 473 TKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDEN 532
Query: 395 KLDHKCW------------AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+ + V +SP+ + +A S D ++++ ++ + + H
Sbjct: 533 STQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKL 592
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIY 468
V + + DG+ + + S D+++ I+
Sbjct: 593 PVICMDISHDGALIATGSADRNVKIW 618
Score = 53.6 bits (123), Expect = 1e-06
Identities = 60/283 (21%), Positives = 109/283 (38%), Gaps = 16/283 (5%)
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
S + V + +K+W+ + L+ + T+ E + S V P +
Sbjct: 425 SDNIAVLSAAADSIKIWN--RSTLQCIRTMTC-EYALCSFFV-PGDRQVVIGTKTGKLQL 480
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-----NGTVDK--V 311
G + I +W + SPD TGG V + N T + V
Sbjct: 481 YDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSV 540
Query: 312 LDTR----GKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
TR + ++ V++SP+ + +A +V +F V K ++ H V + S
Sbjct: 541 KQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIS 600
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVV 426
L+A+ S D V ++ ++ L H + + F P T+ D I+
Sbjct: 601 HDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW 660
Query: 427 LLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++F + T E H + + + G +VS S DKS+ ++E
Sbjct: 661 DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 41.5 bits (93), Expect = 0.006
Identities = 22/65 (33%), Positives = 34/65 (52%)
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKS 464
+C SPDG +A DGSIR+ L TF H + ++++ G +L S SKD
Sbjct: 71 LCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTD 130
Query: 465 INIYE 469
I +++
Sbjct: 131 IIVWD 135
Score = 34.3 bits (75), Expect = 0.97
Identities = 38/211 (18%), Positives = 81/211 (38%), Gaps = 5/211 (2%)
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVV 236
V+GV ++ I+ V+ +G Y+ ++ V +W + L+ L+G + V
Sbjct: 15 VFGV-IGSQKGNIVFVTL-RGEKGRYVAVPACEH-VFIWDLRKGEKILI--LQGLKQEVT 69
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
+ SPDG +A G+ + + + + G ++A+G
Sbjct: 70 CLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDT 129
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ V+ +IN + L I + + + + + V +D+ T+
Sbjct: 130 DIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVG 189
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNI 387
H V L + K L + ++D + V++I
Sbjct: 190 HRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
>AF090988-1|AAC69625.1| 357|Homo sapiens U5 snRNP-specific 40 kDa
protein protein.
Length = 357
Score = 89.8 bits (213), Expect = 2e-17
Identities = 69/287 (24%), Positives = 124/287 (43%), Gaps = 25/287 (8%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKFTLSVAYSPDGKYIASG 66
+V+ F P+G + S IL++ V L + + Y+ DG + S
Sbjct: 68 EVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSA 127
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF--SPDSQLLLTGSDDGHMKLYDVVHANL 124
+ D + ++D G+ V L+GH + S C+ QL+ TGSDDG +KL+D+
Sbjct: 128 STDKTVAVWDSETGERVKRLKGHTSFVNS-CYPARKSPQLVCTGSDDGTVKLWDIRKKAA 186
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T + VL+V F+ + +SG D ++VWDL + +T + H D V G+ ++
Sbjct: 187 IQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS 245
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE--NNKLELLHTLEGH----EMPVVSV 238
E + Y+++ +DN V+VW K + +G+ E ++
Sbjct: 246 EGS--------------YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 291
Query: 239 AVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPD 285
+ SPDG IA + + ++ + + ++ F PD
Sbjct: 292 SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
Score = 85.4 bits (202), Expect = 4e-16
Identities = 53/184 (28%), Positives = 88/184 (47%), Gaps = 9/184 (4%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
V +GS+ G + ++ + Q + L+V ++ I SG +D I ++D+ Q
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV--------VHANLAGTLSGHA 132
KL +T+ GHA S+ L S + LL+ + D ++++DV G +
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+L ++SPDG + +GSADR V VWD S + + H + V F+ + IIS
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 193 SEDK 196
S DK
Sbjct: 346 SSDK 349
Score = 76.6 bits (180), Expect = 2e-13
Identities = 59/282 (20%), Positives = 122/282 (43%), Gaps = 12/282 (4%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P+ + + G D L+ +W+ + + TL+GH V+ + + DG +
Sbjct: 76 PNGSTLASAGFDRLILLWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 134
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ-VATGGHTGKVTVYGIINGTVDKVLDTRG 316
G++++ ++ +S + + Q V TG G V ++ I +
Sbjct: 135 VWDSETGERVKRLKGHTSFVNSCYPARKSPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTY 194
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
+ +++V ++ I SG + ++D+ Q K+ +T+ HA +V L+ S + L S
Sbjct: 195 Q-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN 253
Query: 377 SNDGYVNVYNIESAALQNKL---------DHKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
+ D V V+++ A + + + + + +SPDG ++A +AD + V
Sbjct: 254 AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
R+L+ H + V F+ D ++S S DK + + E
Sbjct: 314 TTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGE 355
Score = 76.2 bits (179), Expect = 2e-13
Identities = 68/303 (22%), Positives = 125/303 (41%), Gaps = 25/303 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV-HANLAGTLSGHASWVLSVAFSPDG 144
L GH + F P+ L + D + L++V + TL GH+ V+ + ++ DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
S S D+TV VWD ++ + K H V N + S +
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFV---------NSCYPARK----SPQLVC 168
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
TG D VK+W + K + T + + V++V + + I
Sbjct: 169 TGSDDGTVKLW--DIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI----INGTVDKVLDTR----G 316
+ ++ + + + S +GS + + V V+ + K+
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K ++ +WSPDG IA+G+ VY++D + ++L+ + HA ++ +AF P ++ SA
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 377 SND 379
S+D
Sbjct: 346 SSD 348
Score = 57.6 bits (133), Expect = 9e-08
Identities = 36/161 (22%), Positives = 70/161 (43%), Gaps = 8/161 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V + F+ +ISG I ++ + K + ++ S +G Y+ S A+
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
Query: 69 DGIINIFDVA----QGKLVHTLEGHAMSIRS----LCFSPDSQLLLTGSDDGHMKLYDVV 120
D + ++DV + + V +G+ + +SPD + GS D + ++D
Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
+ L GHA + VAF PD +S S+D+ + + ++
Sbjct: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEI 356
Score = 49.6 bits (113), Expect = 2e-05
Identities = 49/253 (19%), Positives = 105/253 (41%), Gaps = 12/253 (4%)
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG-QKIREIQTDSSDMWKIVFSPDG 286
L GHE V P+G T+A ++ S + ++ ++ DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMS-VAWSPDGRYIASGAEGGSVYLFDV 345
S + + V V+ G K L F+ S + + +G++ G+V L+D+
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARKSPQLVCTGSDDGTVKLWDI 181
Query: 346 SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVS 404
+ + T + + V ++ F+ + + S D + V+++ L + H
Sbjct: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEF----RVLHTFEEHTH----IVCGVQFNADGSKL 456
+ S +G + ++A D ++RV + F R + F+ + H + ++ DGSK+
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI 300
Query: 457 VSVSKDKSINIYE 469
+ S D+ + +++
Sbjct: 301 AAGSADRFVYVWD 313
>AF083217-1|AAD45865.1| 943|Homo sapiens WD repeat protein WDR3
protein.
Length = 943
Score = 89.8 bits (213), Expect = 2e-17
Identities = 75/335 (22%), Positives = 150/335 (44%), Gaps = 16/335 (4%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC--FSPDSQLLLTGSD 110
++++S D + S A D I I++ + + + T+ +LC F P + ++ G+
Sbjct: 420 TLSFSSDNIAVLSAAADSI-KIWNRSTLQCIRTMTCEY----ALCSFFVPGDRQVVIGTK 474
Query: 111 DGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTF 170
G ++LYD+ NL T+ H + S++ SPD + FV+G AD++V+ WD + ++ +++
Sbjct: 475 TGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENST 534
Query: 171 KEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEG 230
++ V + ++ VS P++ + LD VK++ + K L +L G
Sbjct: 535 QKRL-SVKQTRTLQLDEDVLCVS--YSPNQKLLAVSLLDCTVKIFYVDTLKFFL--SLYG 589
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
H++PV+ + +S DG IA G + + + + F P
Sbjct: 590 HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFF 649
Query: 291 TGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM 350
T G K+ + + L+ + I +A SP G Y+ S + S+ L++ ++ +
Sbjct: 650 TAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPL 709
Query: 351 L----HTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+ +E A+ S+A + + D Y
Sbjct: 710 ILEEEREMEREAEYEESVAKEDQPAVPGETQGDSY 744
Score = 84.6 bits (200), Expect = 7e-16
Identities = 52/199 (26%), Positives = 92/199 (46%), Gaps = 11/199 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQ-------VLDTR----GKFTLSVAYS 57
+W++ SPD + ++G + + E K E V TR + L V+YS
Sbjct: 499 LWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYS 558
Query: 58 PDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
P+ K +A LD + IF V K +L GH + + + S D L+ TGS D ++K++
Sbjct: 559 PNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIW 618
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
+ + +L H V+ + F P F + D ++ WD D + T + H+ ++
Sbjct: 619 GLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEI 678
Query: 178 WGVKFNAESNKIISVSEDK 196
W + + + ++S S DK
Sbjct: 679 WCLAVSPSGDYVVSSSHDK 697
Score = 84.2 bits (199), Expect = 9e-16
Identities = 46/166 (27%), Positives = 80/166 (48%)
Query: 30 ILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGH 89
+ I+ + G++ +L + + SPDG ++A G DG I IF + G+ T GH
Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
Query: 90 AMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVS 149
+I +L + L +GS D + ++DV++ + L GH + F + V+
Sbjct: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
Query: 150 GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
D V+ WDLD+ C T H +VWG+ +E ++I+ + D
Sbjct: 167 SGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASD 212
Score = 79.8 bits (188), Expect = 2e-14
Identities = 45/151 (29%), Positives = 76/151 (50%)
Query: 15 SPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
SPDG H+ G G I IF + SG+ + ++ Y G +ASG+ D I +
Sbjct: 74 SPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIV 133
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
+DV ++ L+GH +I F + LL+T D +K +D+ + T+ GH +
Sbjct: 134 WDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTE 193
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQ 165
V + + KR ++G++D +RVWD+ +Q
Sbjct: 194 VWGLVLLSEEKRLITGASDSELRVWDIAYLQ 224
Score = 73.7 bits (173), Expect = 1e-12
Identities = 48/189 (25%), Positives = 82/189 (43%), Gaps = 17/189 (8%)
Query: 47 RGKFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLL 106
+G G+Y+A A + + I+D+ +G+ + L+G + LC SPD L
Sbjct: 23 KGNIVFVTLRGEKGRYVAVPACEHVF-IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLA 81
Query: 107 TGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQC 166
G +DG ++++ ++ T +GH + + ++ + G R SGS D + VWD+ +
Sbjct: 82 VGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESG 141
Query: 167 QHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLH 226
+ K H D + F E N +VT G D +VK W +
Sbjct: 142 LYRLKGHKDAITQALFLREKN--------------LLVTSGKDTMVKWWDLDTQ--HCFK 185
Query: 227 TLEGHEMPV 235
T+ GH V
Sbjct: 186 TMVGHRTEV 194
Score = 68.5 bits (160), Expect = 5e-11
Identities = 68/281 (24%), Positives = 121/281 (43%), Gaps = 46/281 (16%)
Query: 7 TDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASG 66
+DV TL FS D V+S + A I I+ + + + + ++ L + P + + G
Sbjct: 416 SDVRTLSFSSDNIAVLSAA-ADSIKIWNRSTLQCIRTMTC--EYALCSFFVPGDRQVVIG 472
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG 126
G + ++D+A G L+ T++ H ++ S+ SPD + +TG D +K +D
Sbjct: 473 TKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDEN 532
Query: 127 TLSGHASW-----------VLSVAFSPDGKRFVSGSADRTVRVWDLDS------------ 163
+ S VL V++SP+ K D TV+++ +D+
Sbjct: 533 STQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKL 592
Query: 164 ----MQCQHT-------FKEHNDQVWGVKFNAESNKIISVSEDK------GPSKDYIVTG 206
M H + N ++WG+ F + +K + +D P T
Sbjct: 593 PVICMDISHDGALIATGSADRNVKIWGLDF-GDCHKSLFAHDDSVMYLQFVPKSHLFFTA 651
Query: 207 GLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
G D+ +K W + +K E + TLEGH + +AVSP G+ +
Sbjct: 652 GKDHKIKQW--DADKFEHIQTLEGHHQEIWCLAVSPSGDYV 690
Score = 62.9 bits (146), Expect = 2e-09
Identities = 45/153 (29%), Positives = 70/153 (45%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV + +SP+ K + + IF V++ K L + + S DG IA+G+
Sbjct: 551 DVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGS 610
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
D + I+ + G +L H S+ L F P S L T D +K +D T
Sbjct: 611 ADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQT 670
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
L GH + +A SP G VS S D+++R+W+
Sbjct: 671 LEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 60.5 bits (140), Expect = 1e-08
Identities = 34/163 (20%), Positives = 78/163 (47%), Gaps = 1/163 (0%)
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
G+KI +Q ++ + SPDG +A G G + ++ +++G + + I ++
Sbjct: 55 GEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLK 114
Query: 324 WSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVN 383
+ G +ASG++ + ++DV L+ ++ H A+ F + LL ++ D V
Sbjct: 115 YDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVK 174
Query: 384 VYNIESA-ALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+++++ + + H+ + + +R+ T A+D +RV
Sbjct: 175 WWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRV 217
Score = 58.8 bits (136), Expect = 4e-08
Identities = 67/289 (23%), Positives = 118/289 (40%), Gaps = 38/289 (13%)
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT---------FKEHNDQ- 176
T+ GH S V +++FS D +S +AD ++++W+ ++QC T F D+
Sbjct: 410 TIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQ 468
Query: 177 -VWGVKFN-------AESNKIISVSEDKG--------PSKDYIVTGGLDNLVKVWSYENN 220
V G K A N + ++ G P + VTGG D VK W +E
Sbjct: 469 VVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELV 528
Query: 221 K----------LELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREI 270
K ++ TL+ E V+ V+ SP+ + +A + +
Sbjct: 529 KDENSTQKRLSVKQTRTLQLDE-DVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSL 587
Query: 271 QTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRY 330
+ + S DG+ +ATG V ++G+ G K L +M + + P
Sbjct: 588 YGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHL 647
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASND 379
+ + + +D + + + T+E H Q + LA SP + S+S+D
Sbjct: 648 FFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHD 696
Score = 54.0 bits (124), Expect = 1e-06
Identities = 40/206 (19%), Positives = 91/206 (44%), Gaps = 15/206 (7%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
SD+ + FS D V + + ++ T+ + ++ + + P R + G
Sbjct: 416 SDVRTLSFSSDNIAVLSAA-ADSIKIWN--RSTLQCIRTMTCEYALCSFFVPGDRQVVIG 472
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQN 394
+ G + L+D++ G +L TI+AH A+ S++ SP + + D V ++ E +N
Sbjct: 473 TKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDEN 532
Query: 395 KLDHKCW------------AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTH 442
+ + V +SP+ + +A S D ++++ ++ + + H
Sbjct: 533 STQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKL 592
Query: 443 IVCGVQFNADGSKLVSVSKDKSINIY 468
V + + DG+ + + S D+++ I+
Sbjct: 593 PVICMDISHDGALIATGSADRNVKIW 618
Score = 53.6 bits (123), Expect = 1e-06
Identities = 60/283 (21%), Positives = 109/283 (38%), Gaps = 16/283 (5%)
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
S + V + +K+W+ + L+ + T+ E + S V P +
Sbjct: 425 SDNIAVLSAAADSIKIWN--RSTLQCIRTMTC-EYALCSFFV-PGDRQVVIGTKTGKLQL 480
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-----NGTVDK--V 311
G + I +W + SPD TGG V + N T + V
Sbjct: 481 YDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSV 540
Query: 312 LDTR----GKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFS 367
TR + ++ V++SP+ + +A +V +F V K ++ H V + S
Sbjct: 541 KQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIS 600
Query: 368 PKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVV 426
L+A+ S D V ++ ++ L H + + F P T+ D I+
Sbjct: 601 HDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW 660
Query: 427 LLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++F + T E H + + + G +VS S DKS+ ++E
Sbjct: 661 DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Score = 41.5 bits (93), Expect = 0.006
Identities = 22/65 (33%), Positives = 34/65 (52%)
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKS 464
+C SPDG +A DGSIR+ L TF H + ++++ G +L S SKD
Sbjct: 71 LCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTD 130
Query: 465 INIYE 469
I +++
Sbjct: 131 IIVWD 135
Score = 34.3 bits (75), Expect = 0.97
Identities = 38/211 (18%), Positives = 81/211 (38%), Gaps = 5/211 (2%)
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVV 236
V+GV ++ I+ V+ +G Y+ ++ V +W + L+ L+G + V
Sbjct: 15 VFGV-IGSQKGNIVFVTL-RGEKGRYVAVPACEH-VFIWDLRKGEKILI--LQGLKQEVT 69
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
+ SPDG +A G+ + + + + G ++A+G
Sbjct: 70 CLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDT 129
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ V+ +IN + L I + + + + + V +D+ T+
Sbjct: 130 DIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVG 189
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNI 387
H V L + K L + ++D + V++I
Sbjct: 190 HRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
>AB001517-2|BAA21137.1| 919|Homo sapiens PWP2 protein protein.
Length = 919
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/325 (25%), Positives = 139/325 (42%), Gaps = 37/325 (11%)
Query: 53 SVAYSPDGKYIASGALD-GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDD 111
SVA + G +IA G G + +++ V +GH S+ +L +SPD Q ++TG DD
Sbjct: 335 SVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDD 394
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
G +K+++ + T + H+S V V F+ G V+ S D TVR +DL + TF
Sbjct: 395 GKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNL-VKVWSYENNKLELLHTLEG 230
+ + V+ D S + + G D+ + VWS + + LL L G
Sbjct: 455 -----------SPRPTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGR--LLDVLSG 499
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
HE P+ + +P +A + +E +SD + F PDG+++A
Sbjct: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELA 559
Query: 291 TGGHTGKVTVY--------GIINGTVD-----KVLD-------TRGKFIMSVAWSPDGRY 330
++T + G I G D K LD +GK ++ +S DG
Sbjct: 560 VATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHS 619
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIE 355
I +G V ++ V + ++ E
Sbjct: 620 ILAGGMSKFVCIYHVREQILMKRFE 644
Score = 78.2 bits (184), Expect = 6e-14
Identities = 99/479 (20%), Positives = 203/479 (42%), Gaps = 24/479 (5%)
Query: 9 VWTLDFSPDG-KHVISGSNAGKILIF-GVESGKQEQVLDTR--GKF--TLSVAYSPDGKY 62
V ++ FSPDG K V++ N ++ G + VLD G + T + ++ D +
Sbjct: 99 VHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRC 158
Query: 63 IASGALDGIINIFDVAQ--GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
G+ D +F + + + L GH +I + F +S L + S DG + ++
Sbjct: 159 FVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCD 218
Query: 121 HANLAGTLSGHASW---VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
L A W +L + + G + T+R + + + T K ++
Sbjct: 219 TPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEE-EKTGKVKYSRL 277
Query: 178 WGVKFNAES--NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPV 235
FN E N + + + K +VTG + + +E + L+H+L + +
Sbjct: 278 AKYFFNKEGDFNNLTAAAFHK--KSHLLVTGFASGIFHL--HELPEFNLIHSLSISDQSI 333
Query: 236 VSVAVSPDGETIAXXXXXXXXXXXXXXXGQK-IREIQTDSSDMWKIVFSPDGSQVATGGH 294
SVA++ G+ IA + + + Q + M + +SPDG + TGG
Sbjct: 334 ASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGD 393
Query: 295 TGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI 354
GKV V+ ++G + V ++ G + + + G+V FD+ + + T
Sbjct: 394 DGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTF 453
Query: 355 EAHAQAVRS-LAFSPKTKLLASASNDGY-VNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
+ S +A +++++ + D + + V+++++ L + L H+ +CF+P
Sbjct: 454 TSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
Query: 412 QRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+A+++ D ++R+ + + +R T T V F DG++L + + I ++
Sbjct: 514 SVLASASWDKTVRLWDMFDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWD 571
Score = 38.3 bits (85), Expect = 0.059
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 15/208 (7%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKV-LDTRGKFIMSVAWSPDGRYIASGAEGGSV 340
F+ DG+ V + +VTV+ + N D + L TR + V SPDGR EGG
Sbjct: 22 FTCDGNSVISPVGN-RVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGGDA 79
Query: 341 YLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE------SAALQN 394
L + +LH +V S++FSP + + +Y+ +A + +
Sbjct: 80 LLVSLVCRSVLHHFHFKG-SVHSVSFSPDGRKFV-VTKGNIAQMYHAPGKKREFNAFVLD 137
Query: 395 KLDHKCWAVSVC--FSPDGQRMATSAADGSIRVVLLEEF--RVLHTFEEHTHIVCGVQFN 450
K + + C ++ D + + D S V E + + + H + F
Sbjct: 138 KTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFE 197
Query: 451 ADGSKLVSVSKDKSINIYECPIPPKSAK 478
++ L S+S+D + +++C PP+ +
Sbjct: 198 SNSLDLYSLSQDGVLCMWQCDTPPEGLR 225
>EF011621-1|ABK41111.1| 357|Homo sapiens CDW11/WDR57 protein.
Length = 357
Score = 89.4 bits (212), Expect = 2e-17
Identities = 69/287 (24%), Positives = 124/287 (43%), Gaps = 25/287 (8%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKFTLSVAYSPDGKYIASG 66
+V+ F P+G + S IL++ V L + + Y+ DG + S
Sbjct: 68 EVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSA 127
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP--DSQLLLTGSDDGHMKLYDVVHANL 124
+ D + ++D G+ V L+GH + S C+ QL+ TGSDDG +KL+D+
Sbjct: 128 STDKTVAVWDSETGERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTVKLWDIRKKAA 186
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T + VL+V F+ + +SG D ++VWDL + +T + H D V G+ ++
Sbjct: 187 IQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS 245
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE--NNKLELLHTLEGH----EMPVVSV 238
E + Y+++ +DN V+VW K + +G+ E ++
Sbjct: 246 EGS--------------YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 291
Query: 239 AVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPD 285
+ SPDG IA + + ++ + + ++ F PD
Sbjct: 292 SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
Score = 85.4 bits (202), Expect = 4e-16
Identities = 53/184 (28%), Positives = 88/184 (47%), Gaps = 9/184 (4%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
V +GS+ G + ++ + Q + L+V ++ I SG +D I ++D+ Q
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV--------VHANLAGTLSGHA 132
KL +T+ GHA S+ L S + LL+ + D ++++DV G +
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+L ++SPDG + +GSADR V VWD S + + H + V F+ + IIS
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 193 SEDK 196
S DK
Sbjct: 346 SSDK 349
Score = 78.6 bits (185), Expect = 5e-14
Identities = 60/282 (21%), Positives = 123/282 (43%), Gaps = 12/282 (4%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P+ + + G D L+ +W+ + + TL+GH V+ + + DG +
Sbjct: 76 PNGSTLASAGFDRLILLWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 134
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ-VATGGHTGKVTVYGIINGTVDKVLDTRG 316
G++++ ++ +S + + G Q V TG G V ++ I +
Sbjct: 135 VWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTY 194
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
+ +++V ++ I SG + ++D+ Q K+ +T+ HA +V L+ S + L S
Sbjct: 195 Q-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN 253
Query: 377 SNDGYVNVYNIESAALQNKL---------DHKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
+ D V V+++ A + + + + + +SPDG ++A +AD + V
Sbjct: 254 AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
R+L+ H + V F+ D ++S S DK + + E
Sbjct: 314 TTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGE 355
Score = 77.0 bits (181), Expect = 1e-13
Identities = 69/303 (22%), Positives = 126/303 (41%), Gaps = 25/303 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV-HANLAGTLSGHASWVLSVAFSPDG 144
L GH + F P+ L + D + L++V + TL GH+ V+ + ++ DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
S S D+TV VWD ++ + K H V N +GP +
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFV---------NSCYPAR--RGP--QLVC 168
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
TG D VK+W + K + T + + V++V + + I
Sbjct: 169 TGSDDGTVKLW--DIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI----INGTVDKVLDTR----G 316
+ ++ + + + S +GS + + V V+ + K+
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K ++ +WSPDG IA+G+ VY++D + ++L+ + HA ++ +AF P ++ SA
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 377 SND 379
S+D
Sbjct: 346 SSD 348
Score = 57.6 bits (133), Expect = 9e-08
Identities = 36/161 (22%), Positives = 70/161 (43%), Gaps = 8/161 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V + F+ +ISG I ++ + K + ++ S +G Y+ S A+
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
Query: 69 DGIINIFDVA----QGKLVHTLEGHAMSIRS----LCFSPDSQLLLTGSDDGHMKLYDVV 120
D + ++DV + + V +G+ + +SPD + GS D + ++D
Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
+ L GHA + VAF PD +S S+D+ + + ++
Sbjct: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEI 356
Score = 51.6 bits (118), Expect = 6e-06
Identities = 50/253 (19%), Positives = 107/253 (42%), Gaps = 12/253 (4%)
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG-QKIREIQTDSSDMWKIVFSPDG 286
L GHE V P+G T+A ++ S + ++ ++ DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDG-RYIASGAEGGSVYLFDV 345
S + + V V+ G K L F+ S + G + + +G++ G+V L+D+
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 346 SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVS 404
+ + T + + V ++ F+ + + S D + V+++ L + H
Sbjct: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEF----RVLHTFEEHTH----IVCGVQFNADGSKL 456
+ S +G + ++A D ++RV + F R + F+ + H + ++ DGSK+
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI 300
Query: 457 VSVSKDKSINIYE 469
+ S D+ + +++
Sbjct: 301 AAGSADRFVYVWD 313
>BC013997-1|AAH13997.1| 353|Homo sapiens guanine nucleotide binding
protein (G protein), beta 5 protein.
Length = 353
Score = 89.4 bits (212), Expect = 2e-17
Identities = 52/195 (26%), Positives = 92/195 (47%), Gaps = 8/195 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V +D+ D + ++S S GK++++ + +E + + ++ AY+P G IA G L
Sbjct: 66 VLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGL 125
Query: 69 DGIINIFDVAQGKLVH------TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
D +++ + K + ++ H + + F+ +LT S DG L+DV
Sbjct: 126 DNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 185
Query: 123 NLAGTLSGHASWVLSVAFSPD--GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
L + GH + VL + +P G FVSG D+ VWD+ S QC F+ H + V
Sbjct: 186 QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSV 245
Query: 181 KFNAESNKIISVSED 195
++ + S S+D
Sbjct: 246 RYYPSGDAFASGSDD 260
Score = 83.4 bits (197), Expect = 2e-15
Identities = 50/156 (32%), Positives = 78/156 (50%), Gaps = 4/156 (2%)
Query: 8 DVWTLDFSPD--GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
DV LD +P G +SG K +++ + SG+ Q +T SV Y P G AS
Sbjct: 197 DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFAS 256
Query: 66 GALDGIINIFDVAQGK--LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN 123
G+ D ++D+ + +++ E S+ FS +LL G +D + ++DV+ +
Sbjct: 257 GSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGS 316
Query: 124 LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L GH + V ++ SPDG F SGS D T+RVW
Sbjct: 317 RVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 80.2 bits (189), Expect = 1e-14
Identities = 68/310 (21%), Positives = 126/310 (40%), Gaps = 16/310 (5%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
K TL+GH + + + D + +++ S DG + ++D N ++ +WV++ A+
Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 113
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G G D V+ L TF ++ + K A +S S
Sbjct: 114 APSGCAIACGGLDNKCSVYPL-------TFDKNENMAAKKKSVAMHTNYLSACSFTN-SD 165
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD--GETIAXXXXXXXXXX 258
I+T D +W E+ +LL + GH V+ + ++P G T
Sbjct: 166 MQILTASGDGTCALWDVESG--QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 223
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF 318
GQ ++ +T SD+ + + P G A+G +Y + + + ++
Sbjct: 224 WDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD-LRADREVAIYSKESI 282
Query: 319 IM---SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
I SV +S GR + +G ++ ++DV +G + + H V +L SP S
Sbjct: 283 IFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCS 342
Query: 376 ASNDGYVNVY 385
S D + V+
Sbjct: 343 GSWDHTLRVW 352
Score = 52.0 bits (119), Expect = 4e-06
Identities = 31/118 (26%), Positives = 58/118 (49%), Gaps = 2/118 (1%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF--TLSVAYSPD 59
FET +D+ ++ + P G SGS+ ++ + + ++ + SV +S
Sbjct: 235 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLS 294
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G+ + +G D IN++DV +G V L GH + +L SPD +GS D ++++
Sbjct: 295 GRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 49.2 bits (112), Expect = 3e-05
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 7/193 (3%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD--GRYIASGAEGGS 339
F+ Q+ T G ++ + +G + + G ++ + +P G SG
Sbjct: 161 FTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKK 220
Query: 340 VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES---AALQNKL 396
++D+ G+ + E H + S+ + P AS S+D +Y++ + A+ +K
Sbjct: 221 AMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKE 280
Query: 397 DHKCWAVSVCFSPDGQRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
A SV FS G+ + D +I V +L+ RV F H + V ++ + DG+
Sbjct: 281 SIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILF-GHENRVSTLRVSPDGTA 339
Query: 456 LVSVSKDKSINIY 468
S S D ++ ++
Sbjct: 340 FCSGSWDHTLRVW 352
Score = 47.6 bits (108), Expect = 1e-04
Identities = 41/194 (21%), Positives = 80/194 (41%), Gaps = 9/194 (4%)
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGG--SVY- 341
D ++ + GKV V+ + + ++M+ A++P G IA G SVY
Sbjct: 74 DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 133
Query: 342 -LFDVSQGKMLH--TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL-QNKLD 397
FD ++ ++ H + + +F+ + +AS DG ++++ES L Q+
Sbjct: 134 LTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHG 193
Query: 398 HKCWAVSVCFSPD--GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
H + + +P G + D V + + + FE H + V++ G
Sbjct: 194 HGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDA 253
Query: 456 LVSVSKDKSINIYE 469
S S D + +Y+
Sbjct: 254 FASGSDDATCRLYD 267
>BC001494-1|AAH01494.1| 357|Homo sapiens WD repeat domain 57 (U5
snRNP specific) protein.
Length = 357
Score = 89.4 bits (212), Expect = 2e-17
Identities = 69/287 (24%), Positives = 124/287 (43%), Gaps = 25/287 (8%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKFTLSVAYSPDGKYIASG 66
+V+ F P+G + S IL++ V L + + Y+ DG + S
Sbjct: 68 EVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSA 127
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP--DSQLLLTGSDDGHMKLYDVVHANL 124
+ D + ++D G+ V L+GH + S C+ QL+ TGSDDG +KL+D+
Sbjct: 128 STDKTVAVWDSETGERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTVKLWDIRKKAA 186
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T + VL+V F+ + +SG D ++VWDL + +T + H D V G+ ++
Sbjct: 187 IQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS 245
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE--NNKLELLHTLEGH----EMPVVSV 238
E + Y+++ +DN V+VW K + +G+ E ++
Sbjct: 246 EGS--------------YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 291
Query: 239 AVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPD 285
+ SPDG IA + + ++ + + ++ F PD
Sbjct: 292 SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
Score = 85.4 bits (202), Expect = 4e-16
Identities = 53/184 (28%), Positives = 88/184 (47%), Gaps = 9/184 (4%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
V +GS+ G + ++ + Q + L+V ++ I SG +D I ++D+ Q
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV--------VHANLAGTLSGHA 132
KL +T+ GHA S+ L S + LL+ + D ++++DV G +
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+L ++SPDG + +GSADR V VWD S + + H + V F+ + IIS
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 193 SEDK 196
S DK
Sbjct: 346 SSDK 349
Score = 78.6 bits (185), Expect = 5e-14
Identities = 60/282 (21%), Positives = 123/282 (43%), Gaps = 12/282 (4%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P+ + + G D L+ +W+ + + TL+GH V+ + + DG +
Sbjct: 76 PNGSTLASAGFDRLILLWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 134
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ-VATGGHTGKVTVYGIINGTVDKVLDTRG 316
G++++ ++ +S + + G Q V TG G V ++ I +
Sbjct: 135 VWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTY 194
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
+ +++V ++ I SG + ++D+ Q K+ +T+ HA +V L+ S + L S
Sbjct: 195 Q-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN 253
Query: 377 SNDGYVNVYNIESAALQNKL---------DHKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
+ D V V+++ A + + + + + +SPDG ++A +AD + V
Sbjct: 254 AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
R+L+ H + V F+ D ++S S DK + + E
Sbjct: 314 TTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGE 355
Score = 77.0 bits (181), Expect = 1e-13
Identities = 69/303 (22%), Positives = 126/303 (41%), Gaps = 25/303 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV-HANLAGTLSGHASWVLSVAFSPDG 144
L GH + F P+ L + D + L++V + TL GH+ V+ + ++ DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
S S D+TV VWD ++ + K H V N +GP +
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFV---------NSCYPAR--RGP--QLVC 168
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
TG D VK+W + K + T + + V++V + + I
Sbjct: 169 TGSDDGTVKLW--DIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI----INGTVDKVLDTR----G 316
+ ++ + + + S +GS + + V V+ + K+
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K ++ +WSPDG IA+G+ VY++D + ++L+ + HA ++ +AF P ++ SA
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 377 SND 379
S+D
Sbjct: 346 SSD 348
Score = 57.6 bits (133), Expect = 9e-08
Identities = 36/161 (22%), Positives = 70/161 (43%), Gaps = 8/161 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V + F+ +ISG I ++ + K + ++ S +G Y+ S A+
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
Query: 69 DGIINIFDVA----QGKLVHTLEGHAMSIRS----LCFSPDSQLLLTGSDDGHMKLYDVV 120
D + ++DV + + V +G+ + +SPD + GS D + ++D
Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
+ L GHA + VAF PD +S S+D+ + + ++
Sbjct: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEI 356
Score = 51.6 bits (118), Expect = 6e-06
Identities = 50/253 (19%), Positives = 107/253 (42%), Gaps = 12/253 (4%)
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG-QKIREIQTDSSDMWKIVFSPDG 286
L GHE V P+G T+A ++ S + ++ ++ DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDG-RYIASGAEGGSVYLFDV 345
S + + V V+ G K L F+ S + G + + +G++ G+V L+D+
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 346 SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVS 404
+ + T + + V ++ F+ + + S D + V+++ L + H
Sbjct: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEF----RVLHTFEEHTH----IVCGVQFNADGSKL 456
+ S +G + ++A D ++RV + F R + F+ + H + ++ DGSK+
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI 300
Query: 457 VSVSKDKSINIYE 469
+ S D+ + +++
Sbjct: 301 AAGSADRFVYVWD 313
>AL451070-1|CAH71848.1| 357|Homo sapiens WD repeat domain 57 (U5
snRNP specific) protein.
Length = 357
Score = 89.4 bits (212), Expect = 2e-17
Identities = 69/287 (24%), Positives = 124/287 (43%), Gaps = 25/287 (8%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKFTLSVAYSPDGKYIASG 66
+V+ F P+G + S IL++ V L + + Y+ DG + S
Sbjct: 68 EVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSA 127
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP--DSQLLLTGSDDGHMKLYDVVHANL 124
+ D + ++D G+ V L+GH + S C+ QL+ TGSDDG +KL+D+
Sbjct: 128 STDKTVAVWDSETGERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTVKLWDIRKKAA 186
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T + VL+V F+ + +SG D ++VWDL + +T + H D V G+ ++
Sbjct: 187 IQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS 245
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE--NNKLELLHTLEGH----EMPVVSV 238
E + Y+++ +DN V+VW K + +G+ E ++
Sbjct: 246 EGS--------------YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 291
Query: 239 AVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPD 285
+ SPDG IA + + ++ + + ++ F PD
Sbjct: 292 SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
Score = 85.4 bits (202), Expect = 4e-16
Identities = 53/184 (28%), Positives = 88/184 (47%), Gaps = 9/184 (4%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
V +GS+ G + ++ + Q + L+V ++ I SG +D I ++D+ Q
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV--------VHANLAGTLSGHA 132
KL +T+ GHA S+ L S + LL+ + D ++++DV G +
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+L ++SPDG + +GSADR V VWD S + + H + V F+ + IIS
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 193 SEDK 196
S DK
Sbjct: 346 SSDK 349
Score = 78.6 bits (185), Expect = 5e-14
Identities = 60/282 (21%), Positives = 123/282 (43%), Gaps = 12/282 (4%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P+ + + G D L+ +W+ + + TL+GH V+ + + DG +
Sbjct: 76 PNGSTLASAGFDRLILLWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 134
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ-VATGGHTGKVTVYGIINGTVDKVLDTRG 316
G++++ ++ +S + + G Q V TG G V ++ I +
Sbjct: 135 VWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTY 194
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
+ +++V ++ I SG + ++D+ Q K+ +T+ HA +V L+ S + L S
Sbjct: 195 Q-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN 253
Query: 377 SNDGYVNVYNIESAALQNKL---------DHKCWAVSVCFSPDGQRMATSAADGSIRVVL 427
+ D V V+++ A + + + + + +SPDG ++A +AD + V
Sbjct: 254 AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Query: 428 LEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
R+L+ H + V F+ D ++S S DK + + E
Sbjct: 314 TTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGE 355
Score = 77.0 bits (181), Expect = 1e-13
Identities = 69/303 (22%), Positives = 126/303 (41%), Gaps = 25/303 (8%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV-HANLAGTLSGHASWVLSVAFSPDG 144
L GH + F P+ L + D + L++V + TL GH+ V+ + ++ DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 145 KRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIV 204
S S D+TV VWD ++ + K H V N +GP +
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFV---------NSCYPAR--RGP--QLVC 168
Query: 205 TGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG 264
TG D VK+W + K + T + + V++V + + I
Sbjct: 169 TGSDDGTVKLW--DIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 265 QKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI----INGTVDKVLDTR----G 316
+ ++ + + + S +GS + + V V+ + K+
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K ++ +WSPDG IA+G+ VY++D + ++L+ + HA ++ +AF P ++ SA
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 377 SND 379
S+D
Sbjct: 346 SSD 348
Score = 57.6 bits (133), Expect = 9e-08
Identities = 36/161 (22%), Positives = 70/161 (43%), Gaps = 8/161 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V + F+ +ISG I ++ + K + ++ S +G Y+ S A+
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
Query: 69 DGIINIFDVA----QGKLVHTLEGHAMSIRS----LCFSPDSQLLLTGSDDGHMKLYDVV 120
D + ++DV + + V +G+ + +SPD + GS D + ++D
Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
+ L GHA + VAF PD +S S+D+ + + ++
Sbjct: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEI 356
Score = 51.6 bits (118), Expect = 6e-06
Identities = 50/253 (19%), Positives = 107/253 (42%), Gaps = 12/253 (4%)
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG-QKIREIQTDSSDMWKIVFSPDG 286
L GHE V P+G T+A ++ S + ++ ++ DG
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDG-RYIASGAEGGSVYLFDV 345
S + + V V+ G K L F+ S + G + + +G++ G+V L+D+
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 346 SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVS 404
+ + T + + V ++ F+ + + S D + V+++ L + H
Sbjct: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEF----RVLHTFEEHTH----IVCGVQFNADGSKL 456
+ S +G + ++A D ++RV + F R + F+ + H + ++ DGSK+
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI 300
Query: 457 VSVSKDKSINIYE 469
+ S D+ + +++
Sbjct: 301 AAGSADRFVYVWD 313
>AF501885-1|AAM15921.1| 353|Homo sapiens guanine nucleotide binding
protein beta 5 protein.
Length = 353
Score = 89.4 bits (212), Expect = 2e-17
Identities = 52/195 (26%), Positives = 92/195 (47%), Gaps = 8/195 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V +D+ D + ++S S GK++++ + +E + + ++ AY+P G IA G L
Sbjct: 66 VLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGL 125
Query: 69 DGIINIFDVAQGKLVH------TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
D +++ + K + ++ H + + F+ +LT S DG L+DV
Sbjct: 126 DNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 185
Query: 123 NLAGTLSGHASWVLSVAFSPD--GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
L + GH + VL + +P G FVSG D+ VWD+ S QC F+ H + V
Sbjct: 186 QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSV 245
Query: 181 KFNAESNKIISVSED 195
++ + S S+D
Sbjct: 246 RYYPSGDAFASGSDD 260
Score = 83.4 bits (197), Expect = 2e-15
Identities = 50/156 (32%), Positives = 78/156 (50%), Gaps = 4/156 (2%)
Query: 8 DVWTLDFSPD--GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
DV LD +P G +SG K +++ + SG+ Q +T SV Y P G AS
Sbjct: 197 DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFAS 256
Query: 66 GALDGIINIFDVAQGK--LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN 123
G+ D ++D+ + +++ E S+ FS +LL G +D + ++DV+ +
Sbjct: 257 GSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGS 316
Query: 124 LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L GH + V ++ SPDG F SGS D T+RVW
Sbjct: 317 RVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 80.2 bits (189), Expect = 1e-14
Identities = 68/310 (21%), Positives = 126/310 (40%), Gaps = 16/310 (5%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
K TL+GH + + + D + +++ S DG + ++D N ++ +WV++ A+
Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 113
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G G D V+ L TF ++ + K A +S S
Sbjct: 114 APSGCAIACGGLDNKCSVYPL-------TFDKNENMAAKKKSVAMHTNYLSACSFTN-SD 165
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD--GETIAXXXXXXXXXX 258
I+T D +W E+ +LL + GH V+ + ++P G T
Sbjct: 166 MQILTASGDGTCALWDVESG--QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 223
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF 318
GQ ++ +T SD+ + + P G A+G +Y + + + ++
Sbjct: 224 WDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD-LRADREVAIYSKESI 282
Query: 319 IM---SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
I SV +S GR + +G ++ ++DV +G + + H V +L SP S
Sbjct: 283 IFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCS 342
Query: 376 ASNDGYVNVY 385
S D + V+
Sbjct: 343 GSWDHTLRVW 352
Score = 52.0 bits (119), Expect = 4e-06
Identities = 31/118 (26%), Positives = 58/118 (49%), Gaps = 2/118 (1%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF--TLSVAYSPD 59
FET +D+ ++ + P G SGS+ ++ + + ++ + SV +S
Sbjct: 235 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLS 294
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G+ + +G D IN++DV +G V L GH + +L SPD +GS D ++++
Sbjct: 295 GRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 49.2 bits (112), Expect = 3e-05
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 7/193 (3%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD--GRYIASGAEGGS 339
F+ Q+ T G ++ + +G + + G ++ + +P G SG
Sbjct: 161 FTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKK 220
Query: 340 VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES---AALQNKL 396
++D+ G+ + E H + S+ + P AS S+D +Y++ + A+ +K
Sbjct: 221 AMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKE 280
Query: 397 DHKCWAVSVCFSPDGQRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
A SV FS G+ + D +I V +L+ RV F H + V ++ + DG+
Sbjct: 281 SIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILF-GHENRVSTLRVSPDGTA 339
Query: 456 LVSVSKDKSINIY 468
S S D ++ ++
Sbjct: 340 FCSGSWDHTLRVW 352
Score = 47.6 bits (108), Expect = 1e-04
Identities = 41/194 (21%), Positives = 80/194 (41%), Gaps = 9/194 (4%)
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGG--SVY- 341
D ++ + GKV V+ + + ++M+ A++P G IA G SVY
Sbjct: 74 DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 133
Query: 342 -LFDVSQGKMLH--TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL-QNKLD 397
FD ++ ++ H + + +F+ + +AS DG ++++ES L Q+
Sbjct: 134 LTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHG 193
Query: 398 HKCWAVSVCFSPD--GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
H + + +P G + D V + + + FE H + V++ G
Sbjct: 194 HGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDA 253
Query: 456 LVSVSKDKSINIYE 469
S S D + +Y+
Sbjct: 254 FASGSDDATCRLYD 267
>AF300650-1|AAG18444.1| 395|Homo sapiens guanine nucleotide binding
protein beta subunit 5L protein.
Length = 395
Score = 89.4 bits (212), Expect = 2e-17
Identities = 52/195 (26%), Positives = 92/195 (47%), Gaps = 8/195 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V +D+ D + ++S S GK++++ + +E + + ++ AY+P G IA G L
Sbjct: 108 VLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGL 167
Query: 69 DGIINIFDVAQGKLVH------TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
D +++ + K + ++ H + + F+ +LT S DG L+DV
Sbjct: 168 DNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 227
Query: 123 NLAGTLSGHASWVLSVAFSPD--GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
L + GH + VL + +P G FVSG D+ VWD+ S QC F+ H + V
Sbjct: 228 QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSV 287
Query: 181 KFNAESNKIISVSED 195
++ + S S+D
Sbjct: 288 RYYPSGDAFASGSDD 302
Score = 83.4 bits (197), Expect = 2e-15
Identities = 50/156 (32%), Positives = 78/156 (50%), Gaps = 4/156 (2%)
Query: 8 DVWTLDFSPD--GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
DV LD +P G +SG K +++ + SG+ Q +T SV Y P G AS
Sbjct: 239 DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFAS 298
Query: 66 GALDGIINIFDVAQGK--LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN 123
G+ D ++D+ + +++ E S+ FS +LL G +D + ++DV+ +
Sbjct: 299 GSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGS 358
Query: 124 LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L GH + V ++ SPDG F SGS D T+RVW
Sbjct: 359 RVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 80.2 bits (189), Expect = 1e-14
Identities = 68/310 (21%), Positives = 126/310 (40%), Gaps = 16/310 (5%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
K TL+GH + + + D + +++ S DG + ++D N ++ +WV++ A+
Sbjct: 96 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 155
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G G D V+ L TF ++ + K A +S S
Sbjct: 156 APSGCAIACGGLDNKCSVYPL-------TFDKNENMAAKKKSVAMHTNYLSACSFTN-SD 207
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD--GETIAXXXXXXXXXX 258
I+T D +W E+ +LL + GH V+ + ++P G T
Sbjct: 208 MQILTASGDGTCALWDVESG--QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 265
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF 318
GQ ++ +T SD+ + + P G A+G +Y + + + ++
Sbjct: 266 WDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD-LRADREVAIYSKESI 324
Query: 319 IM---SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
I SV +S GR + +G ++ ++DV +G + + H V +L SP S
Sbjct: 325 IFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCS 384
Query: 376 ASNDGYVNVY 385
S D + V+
Sbjct: 385 GSWDHTLRVW 394
Score = 52.0 bits (119), Expect = 4e-06
Identities = 31/118 (26%), Positives = 58/118 (49%), Gaps = 2/118 (1%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF--TLSVAYSPD 59
FET +D+ ++ + P G SGS+ ++ + + ++ + SV +S
Sbjct: 277 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLS 336
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G+ + +G D IN++DV +G V L GH + +L SPD +GS D ++++
Sbjct: 337 GRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 49.2 bits (112), Expect = 3e-05
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 7/193 (3%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD--GRYIASGAEGGS 339
F+ Q+ T G ++ + +G + + G ++ + +P G SG
Sbjct: 203 FTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKK 262
Query: 340 VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES---AALQNKL 396
++D+ G+ + E H + S+ + P AS S+D +Y++ + A+ +K
Sbjct: 263 AMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKE 322
Query: 397 DHKCWAVSVCFSPDGQRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
A SV FS G+ + D +I V +L+ RV F H + V ++ + DG+
Sbjct: 323 SIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILF-GHENRVSTLRVSPDGTA 381
Query: 456 LVSVSKDKSINIY 468
S S D ++ ++
Sbjct: 382 FCSGSWDHTLRVW 394
Score = 47.6 bits (108), Expect = 1e-04
Identities = 41/194 (21%), Positives = 80/194 (41%), Gaps = 9/194 (4%)
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGG--SVY- 341
D ++ + GKV V+ + + ++M+ A++P G IA G SVY
Sbjct: 116 DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 175
Query: 342 -LFDVSQGKMLH--TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL-QNKLD 397
FD ++ ++ H + + +F+ + +AS DG ++++ES L Q+
Sbjct: 176 LTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHG 235
Query: 398 HKCWAVSVCFSPD--GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
H + + +P G + D V + + + FE H + V++ G
Sbjct: 236 HGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDA 295
Query: 456 LVSVSKDKSINIYE 469
S S D + +Y+
Sbjct: 296 FASGSDDATCRLYD 309
>AF017656-1|AAC63826.1| 353|Homo sapiens G protein beta 5 subunit
protein.
Length = 353
Score = 89.4 bits (212), Expect = 2e-17
Identities = 52/195 (26%), Positives = 92/195 (47%), Gaps = 8/195 (4%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V +D+ D + ++S S GK++++ + +E + + ++ AY+P G IA G L
Sbjct: 66 VLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGL 125
Query: 69 DGIINIFDVAQGKLVH------TLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHA 122
D +++ + K + ++ H + + F+ +LT S DG L+DV
Sbjct: 126 DNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 185
Query: 123 NLAGTLSGHASWVLSVAFSPD--GKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
L + GH + VL + +P G FVSG D+ VWD+ S QC F+ H + V
Sbjct: 186 QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSV 245
Query: 181 KFNAESNKIISVSED 195
++ + S S+D
Sbjct: 246 RYYPSGDAFASGSDD 260
Score = 83.4 bits (197), Expect = 2e-15
Identities = 50/156 (32%), Positives = 78/156 (50%), Gaps = 4/156 (2%)
Query: 8 DVWTLDFSPD--GKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
DV LD +P G +SG K +++ + SG+ Q +T SV Y P G AS
Sbjct: 197 DVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFAS 256
Query: 66 GALDGIINIFDVAQGK--LVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN 123
G+ D ++D+ + +++ E S+ FS +LL G +D + ++DV+ +
Sbjct: 257 GSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGS 316
Query: 124 LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
L GH + V ++ SPDG F SGS D T+RVW
Sbjct: 317 RVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 80.2 bits (189), Expect = 1e-14
Identities = 68/310 (21%), Positives = 126/310 (40%), Gaps = 16/310 (5%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
K TL+GH + + + D + +++ S DG + ++D N ++ +WV++ A+
Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 113
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
+P G G D V+ L TF ++ + K A +S S
Sbjct: 114 APSGCAIACGGLDNKCSVYPL-------TFDKNENMAAKKKSVAMHTNYLSACSFTN-SD 165
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD--GETIAXXXXXXXXXX 258
I+T D +W E+ +LL + GH V+ + ++P G T
Sbjct: 166 MQILTASGDGTCALWDVESG--QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV 223
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKF 318
GQ ++ +T SD+ + + P G A+G +Y + + + ++
Sbjct: 224 WDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD-LRADREVAIYSKESI 282
Query: 319 IM---SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
I SV +S GR + +G ++ ++DV +G + + H V +L SP S
Sbjct: 283 IFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCS 342
Query: 376 ASNDGYVNVY 385
S D + V+
Sbjct: 343 GSWDHTLRVW 352
Score = 52.0 bits (119), Expect = 4e-06
Identities = 31/118 (26%), Positives = 58/118 (49%), Gaps = 2/118 (1%)
Query: 2 FETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF--TLSVAYSPD 59
FET +D+ ++ + P G SGS+ ++ + + ++ + SV +S
Sbjct: 235 FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLS 294
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
G+ + +G D IN++DV +G V L GH + +L SPD +GS D ++++
Sbjct: 295 GRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 49.2 bits (112), Expect = 3e-05
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 7/193 (3%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPD--GRYIASGAEGGS 339
F+ Q+ T G ++ + +G + + G ++ + +P G SG
Sbjct: 161 FTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKK 220
Query: 340 VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES---AALQNKL 396
++D+ G+ + E H + S+ + P AS S+D +Y++ + A+ +K
Sbjct: 221 AMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKE 280
Query: 397 DHKCWAVSVCFSPDGQRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
A SV FS G+ + D +I V +L+ RV F H + V ++ + DG+
Sbjct: 281 SIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILF-GHENRVSTLRVSPDGTA 339
Query: 456 LVSVSKDKSINIY 468
S S D ++ ++
Sbjct: 340 FCSGSWDHTLRVW 352
Score = 47.6 bits (108), Expect = 1e-04
Identities = 41/194 (21%), Positives = 80/194 (41%), Gaps = 9/194 (4%)
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGG--SVY- 341
D ++ + GKV V+ + + ++M+ A++P G IA G SVY
Sbjct: 74 DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 133
Query: 342 -LFDVSQGKMLH--TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAAL-QNKLD 397
FD ++ ++ H + + +F+ + +AS DG ++++ES L Q+
Sbjct: 134 LTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHG 193
Query: 398 HKCWAVSVCFSPD--GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
H + + +P G + D V + + + FE H + V++ G
Sbjct: 194 HGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDA 253
Query: 456 LVSVSKDKSINIYE 469
S S D + +Y+
Sbjct: 254 FASGSDDATCRLYD 267
>M36430-1|AAA63265.1| 247|Homo sapiens protein ( Human transducin
beta-1 subunit mRNA, 3' end. ).
Length = 247
Score = 88.6 bits (210), Expect = 4e-17
Identities = 46/153 (30%), Positives = 80/153 (52%), Gaps = 5/153 (3%)
Query: 47 RGKFTLSVAYSPDGKYIASGALDGIINIFDV--AQG--KLVHTLEGHAMSIRSLCFSPDS 102
R + ++ AY+P G Y+A G LD I +I+++ +G ++ L GH + F D+
Sbjct: 3 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN 62
Query: 103 QLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
Q ++T S D L+D+ T +GH V+S++ +PD + FVSG+ D + ++WD+
Sbjct: 63 Q-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 121
Query: 163 SMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
C+ TF H + + F N + S+D
Sbjct: 122 EGMCRQTFTGHESDINAICFFPNGNAFATGSDD 154
Score = 81.4 bits (192), Expect = 6e-15
Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 17/243 (6%)
Query: 9 VWTLDFSPDGKHVISGS--NAGKILIFGVESGKQEQVLDTRGKFT-LSVAYSPDGKYIAS 65
V T ++P G +V G N I G + G LS D I +
Sbjct: 7 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVT 66
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
+ D ++D+ G+ T GH + SL +PD++L ++G+ D KL+DV
Sbjct: 67 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 126
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ + G
Sbjct: 127 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICG------ 179
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
I SVS K S ++ G D VW + K + L GH+ V + V+ DG
Sbjct: 180 ---ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCLGVTDDGM 232
Query: 246 TIA 248
+A
Sbjct: 233 AVA 235
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 88 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 147
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 148 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 207
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 208 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 247
Score = 72.5 bits (170), Expect = 3e-12
Identities = 51/204 (25%), Positives = 95/204 (46%), Gaps = 10/204 (4%)
Query: 274 SSDMWKIVFSPDGSQVATGGHTGKVTVYGII----NGTVDKVLDTRGKFIMSVAWSPDGR 329
SS + ++P G+ VA GG ++Y + N V + L ++ + D +
Sbjct: 4 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 63
Query: 330 YIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-E 388
+ S + + L+D+ G+ T H V SL+ +P T+L S + D ++++ E
Sbjct: 64 IVTSSGDT-TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE 122
Query: 389 SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG-- 446
Q H+ ++CF P+G AT + D + R+ L + L T+ H +I+CG
Sbjct: 123 GMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIICGIT 181
Query: 447 -VQFNADGSKLVSVSKDKSINIYE 469
V F+ G L++ D + N+++
Sbjct: 182 SVSFSKSGRLLLAGYDDFNCNVWD 205
Score = 57.6 bits (133), Expect = 9e-08
Identities = 47/233 (20%), Positives = 95/233 (40%), Gaps = 6/233 (2%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXX 255
PS +Y+ GGLDN+ +++ + + + + L GH +S D I
Sbjct: 14 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDDNQIVTSSGDTT 72
Query: 256 XXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTR 315
GQ+ + D+ + +PD +G ++ + G +
Sbjct: 73 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH 132
Query: 316 GKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVRSLAFSPKTKLL 373
I ++ + P+G A+G++ + LFD+ Q M ++ + + S++FS +LL
Sbjct: 133 ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLL 192
Query: 374 ASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+ +D NV++ A L H + + DG +AT + D +++
Sbjct: 193 LAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 245
Score = 44.0 bits (99), Expect = 0.001
Identities = 33/160 (20%), Positives = 69/160 (43%), Gaps = 6/160 (3%)
Query: 315 RGKFIMSVAWSPDGRYIASGAEGG--SVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKT 370
R ++M+ A++P G Y+A G S+Y +G ++ + H + F
Sbjct: 3 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN 62
Query: 371 KLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLE 429
+++ S S D +++IE+ H +S+ +PD + + A D S ++ +
Sbjct: 63 QIVTS-SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 121
Query: 430 EFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
E TF H + + F +G+ + S D + +++
Sbjct: 122 EGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 161
>BC035409-1|AAH35409.1| 808|Homo sapiens transducin (beta)-like 3
protein.
Length = 808
Score = 87.8 bits (208), Expect = 7e-17
Identities = 43/128 (33%), Positives = 71/128 (55%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
SVA +P+ K +A+G+ D ++ + Q +L+ GH + + FSP Q+L T S DG
Sbjct: 484 SVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADG 543
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+KL+ + + T GH + VL VAF G + +S +D V++W + + +C T
Sbjct: 544 TIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDA 603
Query: 173 HNDQVWGV 180
H D+VWG+
Sbjct: 604 HEDKVWGL 611
Score = 85.0 bits (201), Expect = 5e-16
Identities = 99/488 (20%), Positives = 196/488 (40%), Gaps = 34/488 (6%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASG 66
D+ D SPD + +++ S A + + + G ++ ++ +A+ P +A+G
Sbjct: 68 DITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLSKAIHTAPVATMAFDPTSTLLATG 127
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANL 124
DG + ++D+ + H G + + F PD LL + + D ++++ + +
Sbjct: 128 GCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSC 187
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
L+ H S V S+AFS DG +S D+ +WDL S Q T V
Sbjct: 188 LAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPE 247
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL---EGHEMPVVSVAVS 241
E + V K P Y +T G ++VW + + G E+ ++A +
Sbjct: 248 EPVSQLGV---KSPGL-YFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVF-SPDGSQVATGGHTGKVTV 300
A QK + S ++ + F P+ S V ++ + V
Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQK--QFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKV 361
Query: 301 YGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI---EAH 357
+ + + ++L ++++ G AS A+ SV ++ +++ + + H
Sbjct: 362 FE-LQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGH 420
Query: 358 AQAVRSLAFSP-KTKLLASASNDGYVNVYNIESA-------------ALQNKLDHKCW-- 401
+V ++ S K L + S D V ++ + A LQ + +C
Sbjct: 421 THSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDK 480
Query: 402 -AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVS 460
SV +P+ + +AT + D + ++ L + ++L F H + VQF+ L + S
Sbjct: 481 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 540
Query: 461 KDKSINIY 468
D +I ++
Sbjct: 541 ADGTIKLW 548
Score = 81.8 bits (193), Expect = 5e-15
Identities = 48/144 (33%), Positives = 71/144 (49%), Gaps = 16/144 (11%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H I S+ +P+ +LL TGS D KL+ + L G SGH + V FSP +
Sbjct: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ SAD T+++W L C TF+ H+ V V F + +++S G
Sbjct: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLS--------------SGS 583
Query: 209 DNLVKVWSYENNKLELLHTLEGHE 232
D LVK+W+ +NN E + TL+ HE
Sbjct: 584 DGLVKLWTIKNN--ECVRTLDAHE 605
Score = 64.9 bits (151), Expect = 6e-10
Identities = 38/117 (32%), Positives = 62/117 (52%), Gaps = 1/117 (0%)
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T H + + S+A +P KLLA+ S D ++ + L H+ V FSP
Sbjct: 474 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMD 533
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +AT++ADG+I++ L++F L TFE H V V F + G++L+S D + ++
Sbjct: 534 QVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
Score = 61.3 bits (142), Expect = 7e-09
Identities = 78/395 (19%), Positives = 154/395 (38%), Gaps = 25/395 (6%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLE---GHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
G Y + G + +++ A G+ V+T G + + + ++LT + D ++ L
Sbjct: 259 GLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLL 318
Query: 117 YDVVHANLAGTLSGHASWVLSVAF-SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHND 175
Y+ L +G++ VL V F P+ V S ++V++L + CQ H D
Sbjct: 319 YEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTD 377
Query: 176 QVWGVKFNAESNKIISVSEDKG--------PSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
V + + S ++D+ + V G + V + ++L+
Sbjct: 378 IVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFL 437
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGS 287
+ G + V + P Q+ + D+ + +P+
Sbjct: 438 VTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHD-----KDINSVAIAPNDK 492
Query: 288 QVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQ 347
+ATG ++ + + V + + V +SP + +A+ + G++ L+ +
Sbjct: 493 LLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQD 552
Query: 348 GKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWAVS 404
L T E H +V +AF + L S+ +DG V ++ I++ LD K W +
Sbjct: 553 FSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLH 612
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE 439
C D + T A+D RV+L ++ EE
Sbjct: 613 -CSRLDDHAL-TGASDS--RVILWKDVTEAEQAEE 643
Score = 60.9 bits (141), Expect = 1e-08
Identities = 37/151 (24%), Positives = 77/151 (50%), Gaps = 2/151 (1%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I SVA +P+ + +A+G++ + L+ + Q ++L H + + + FSP ++LA+A
Sbjct: 480 KDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 539
Query: 377 SNDGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLH 435
S DG + ++ ++ + L+ H + V F G ++ +S +DG +++ ++ +
Sbjct: 540 SADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVR 599
Query: 436 TFEEHTHIVCGVQFN-ADGSKLVSVSKDKSI 465
T + H V G+ + D L S + I
Sbjct: 600 TLDAHEDKVWGLHCSRLDDHALTGASDSRVI 630
Score = 57.2 bits (132), Expect = 1e-07
Identities = 47/178 (26%), Positives = 82/178 (46%), Gaps = 5/178 (2%)
Query: 297 KVTVYGIINGTVDKVLDTRGKF-IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+V + + +G V + L+ + I + SPD + + + + + +G + +
Sbjct: 46 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLSK 105
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVS-VCFSPDGQR 413
A H V ++AF P + LLA+ DG V V++I + V V F PD R
Sbjct: 106 AIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTR 165
Query: 414 MA--TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ +SA D +IRV L++ L H V + F+ADG ++S +DK I++
Sbjct: 166 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
Score = 54.0 bits (124), Expect = 1e-06
Identities = 38/153 (24%), Positives = 73/153 (47%), Gaps = 2/153 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D+ ++ +P+ K + +GS ++ + + V + V +SP + +A+ +
Sbjct: 481 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 540
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDDGHMKLYDVVHANLAG 126
DG I ++ + + T EGH S+ + F S +QLL +GS DG +KL+ + +
Sbjct: 541 ADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGS-DGLVKLWTIKNNECVR 599
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL H V + S ++G++D V +W
Sbjct: 600 TLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 45.2 bits (102), Expect = 5e-04
Identities = 38/170 (22%), Positives = 70/170 (41%), Gaps = 4/170 (2%)
Query: 224 LLHTLEGHEMP-VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT-DSSDMWKIV 281
+L +LE + + + +SPD E + G R + ++ + +
Sbjct: 57 VLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLSKAIHTAPVATMA 116
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA--SGAEGGS 339
F P + +ATGG G V V+ I+ + VA+ PD + S A +
Sbjct: 117 FDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAA 176
Query: 340 VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES 389
+ ++ + L + AH AV SLAFS + S+ D +++++S
Sbjct: 177 IRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
>BC014007-1|AAH14007.1| 808|Homo sapiens TBL3 protein protein.
Length = 808
Score = 87.8 bits (208), Expect = 7e-17
Identities = 43/128 (33%), Positives = 71/128 (55%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
SVA +P+ K +A+G+ D ++ + Q +L+ GH + + FSP Q+L T S DG
Sbjct: 484 SVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADG 543
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+KL+ + + T GH + VL VAF G + +S +D V++W + + +C T
Sbjct: 544 TIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDA 603
Query: 173 HNDQVWGV 180
H D+VWG+
Sbjct: 604 HEDKVWGL 611
Score = 85.0 bits (201), Expect = 5e-16
Identities = 99/488 (20%), Positives = 196/488 (40%), Gaps = 34/488 (6%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASG 66
D+ D SPD + +++ S A + + + G ++ ++ +A+ P +A+G
Sbjct: 68 DITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATG 127
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANL 124
DG + ++D+ + H G + + F PD LL + + D ++++ + +
Sbjct: 128 GCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSC 187
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
L+ H S V S+AFS DG +S D+ +WDL S Q T V
Sbjct: 188 LAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPE 247
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL---EGHEMPVVSVAVS 241
E + V K P Y +T G ++VW + + G E+ ++A +
Sbjct: 248 EPVSQLGV---KSPGL-YFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVF-SPDGSQVATGGHTGKVTV 300
A QK + S ++ + F P+ S V ++ + V
Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQK--QFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKV 361
Query: 301 YGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI---EAH 357
+ + + ++L ++++ G AS A+ SV ++ +++ + + H
Sbjct: 362 FE-LQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGH 420
Query: 358 AQAVRSLAFSP-KTKLLASASNDGYVNVYNIESA-------------ALQNKLDHKCW-- 401
+V ++ S K L + S D V ++ + A LQ + +C
Sbjct: 421 THSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDK 480
Query: 402 -AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVS 460
SV +P+ + +AT + D + ++ L + ++L F H + VQF+ L + S
Sbjct: 481 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 540
Query: 461 KDKSINIY 468
D +I ++
Sbjct: 541 ADGTIKLW 548
Score = 81.8 bits (193), Expect = 5e-15
Identities = 48/144 (33%), Positives = 71/144 (49%), Gaps = 16/144 (11%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H I S+ +P+ +LL TGS D KL+ + L G SGH + V FSP +
Sbjct: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ SAD T+++W L C TF+ H+ V V F + +++S G
Sbjct: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLS--------------SGS 583
Query: 209 DNLVKVWSYENNKLELLHTLEGHE 232
D LVK+W+ +NN E + TL+ HE
Sbjct: 584 DGLVKLWTIKNN--ECVRTLDAHE 605
Score = 64.9 bits (151), Expect = 6e-10
Identities = 38/117 (32%), Positives = 62/117 (52%), Gaps = 1/117 (0%)
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T H + + S+A +P KLLA+ S D ++ + L H+ V FSP
Sbjct: 474 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMD 533
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +AT++ADG+I++ L++F L TFE H V V F + G++L+S D + ++
Sbjct: 534 QVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
Score = 61.3 bits (142), Expect = 7e-09
Identities = 78/395 (19%), Positives = 154/395 (38%), Gaps = 25/395 (6%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLE---GHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
G Y + G + +++ A G+ V+T G + + + ++LT + D ++ L
Sbjct: 259 GLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLL 318
Query: 117 YDVVHANLAGTLSGHASWVLSVAF-SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHND 175
Y+ L +G++ VL V F P+ V S ++V++L + CQ H D
Sbjct: 319 YEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTD 377
Query: 176 QVWGVKFNAESNKIISVSEDKG--------PSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
V + + S ++D+ + V G + V + ++L+
Sbjct: 378 IVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFL 437
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGS 287
+ G + V + P Q+ + D+ + +P+
Sbjct: 438 VTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHD-----KDINSVAIAPNDK 492
Query: 288 QVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQ 347
+ATG ++ + + V + + V +SP + +A+ + G++ L+ +
Sbjct: 493 LLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQD 552
Query: 348 GKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWAVS 404
L T E H +V +AF + L S+ +DG V ++ I++ LD K W +
Sbjct: 553 FSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLH 612
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE 439
C D + T A+D RV+L ++ EE
Sbjct: 613 -CSRLDDHAL-TGASDS--RVILWKDVTEAEQAEE 643
Score = 60.9 bits (141), Expect = 1e-08
Identities = 37/151 (24%), Positives = 77/151 (50%), Gaps = 2/151 (1%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I SVA +P+ + +A+G++ + L+ + Q ++L H + + + FSP ++LA+A
Sbjct: 480 KDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 539
Query: 377 SNDGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLH 435
S DG + ++ ++ + L+ H + V F G ++ +S +DG +++ ++ +
Sbjct: 540 SADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVR 599
Query: 436 TFEEHTHIVCGVQFN-ADGSKLVSVSKDKSI 465
T + H V G+ + D L S + I
Sbjct: 600 TLDAHEDKVWGLHCSRLDDHALTGASDSRVI 630
Score = 56.8 bits (131), Expect = 2e-07
Identities = 47/178 (26%), Positives = 82/178 (46%), Gaps = 5/178 (2%)
Query: 297 KVTVYGIINGTVDKVLDTRGKF-IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+V + + +G V + L+ + I + SPD + + + + + +G + +
Sbjct: 46 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWK 105
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVS-VCFSPDGQR 413
A H V ++AF P + LLA+ DG V V++I + V V F PD R
Sbjct: 106 AIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTR 165
Query: 414 MA--TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ +SA D +IRV L++ L H V + F+ADG ++S +DK I++
Sbjct: 166 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
Score = 54.0 bits (124), Expect = 1e-06
Identities = 38/153 (24%), Positives = 73/153 (47%), Gaps = 2/153 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D+ ++ +P+ K + +GS ++ + + V + V +SP + +A+ +
Sbjct: 481 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 540
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDDGHMKLYDVVHANLAG 126
DG I ++ + + T EGH S+ + F S +QLL +GS DG +KL+ + +
Sbjct: 541 ADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGS-DGLVKLWTIKNNECVR 599
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL H V + S ++G++D V +W
Sbjct: 600 TLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 44.8 bits (101), Expect = 7e-04
Identities = 38/170 (22%), Positives = 70/170 (41%), Gaps = 4/170 (2%)
Query: 224 LLHTLEGHEMP-VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT-DSSDMWKIV 281
+L +LE + + + +SPD E + G R + ++ + +
Sbjct: 57 VLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMA 116
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA--SGAEGGS 339
F P + +ATGG G V V+ I+ + VA+ PD + S A +
Sbjct: 117 FDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAA 176
Query: 340 VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES 389
+ ++ + L + AH AV SLAFS + S+ D +++++S
Sbjct: 177 IRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
>BC010231-1|AAH10231.1| 808|Homo sapiens transducin (beta)-like 3
protein.
Length = 808
Score = 87.8 bits (208), Expect = 7e-17
Identities = 43/128 (33%), Positives = 71/128 (55%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
SVA +P+ K +A+G+ D ++ + Q +L+ GH + + FSP Q+L T S DG
Sbjct: 484 SVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADG 543
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+KL+ + + T GH + VL VAF G + +S +D V++W + + +C T
Sbjct: 544 TIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDA 603
Query: 173 HNDQVWGV 180
H D+VWG+
Sbjct: 604 HEDKVWGL 611
Score = 85.0 bits (201), Expect = 5e-16
Identities = 99/488 (20%), Positives = 196/488 (40%), Gaps = 34/488 (6%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASG 66
D+ D SPD + +++ S A + + + G ++ ++ +A+ P +A+G
Sbjct: 68 DITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATG 127
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANL 124
DG + ++D+ + H G + + F PD LL + + D ++++ + +
Sbjct: 128 GCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSC 187
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
L+ H S V S+AFS DG +S D+ +WDL S Q T V
Sbjct: 188 LAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPE 247
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL---EGHEMPVVSVAVS 241
E + V K P Y +T G ++VW + + G E+ ++A +
Sbjct: 248 EPVSQLGV---KSPGL-YFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVF-SPDGSQVATGGHTGKVTV 300
A QK + S ++ + F P+ S V ++ + V
Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQK--QFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKV 361
Query: 301 YGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI---EAH 357
+ + + ++L ++++ G AS A+ SV ++ +++ + + H
Sbjct: 362 FE-LQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGH 420
Query: 358 AQAVRSLAFSP-KTKLLASASNDGYVNVYNIESA-------------ALQNKLDHKCW-- 401
+V ++ S K L + S D V ++ + A LQ + +C
Sbjct: 421 THSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDK 480
Query: 402 -AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVS 460
SV +P+ + +AT + D + ++ L + ++L F H + VQF+ L + S
Sbjct: 481 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 540
Query: 461 KDKSINIY 468
D +I ++
Sbjct: 541 ADGTIKLW 548
Score = 81.8 bits (193), Expect = 5e-15
Identities = 48/144 (33%), Positives = 71/144 (49%), Gaps = 16/144 (11%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H I S+ +P+ +LL TGS D KL+ + L G SGH + V FSP +
Sbjct: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ SAD T+++W L C TF+ H+ V V F + +++S G
Sbjct: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLS--------------SGS 583
Query: 209 DNLVKVWSYENNKLELLHTLEGHE 232
D LVK+W+ +NN E + TL+ HE
Sbjct: 584 DGLVKLWTIKNN--ECVRTLDAHE 605
Score = 64.9 bits (151), Expect = 6e-10
Identities = 38/117 (32%), Positives = 62/117 (52%), Gaps = 1/117 (0%)
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T H + + S+A +P KLLA+ S D ++ + L H+ V FSP
Sbjct: 474 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMD 533
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +AT++ADG+I++ L++F L TFE H V V F + G++L+S D + ++
Sbjct: 534 QVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
Score = 61.3 bits (142), Expect = 7e-09
Identities = 78/395 (19%), Positives = 154/395 (38%), Gaps = 25/395 (6%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLE---GHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
G Y + G + +++ A G+ V+T G + + + ++LT + D ++ L
Sbjct: 259 GLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLL 318
Query: 117 YDVVHANLAGTLSGHASWVLSVAF-SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHND 175
Y+ L +G++ VL V F P+ V S ++V++L + CQ H D
Sbjct: 319 YEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTD 377
Query: 176 QVWGVKFNAESNKIISVSEDKG--------PSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
V + + S ++D+ + V G + V + ++L+
Sbjct: 378 IVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFL 437
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGS 287
+ G + V + P Q+ + D+ + +P+
Sbjct: 438 VTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHD-----KDINSVAIAPNDK 492
Query: 288 QVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQ 347
+ATG ++ + + V + + V +SP + +A+ + G++ L+ +
Sbjct: 493 LLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQD 552
Query: 348 GKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWAVS 404
L T E H +V +AF + L S+ +DG V ++ I++ LD K W +
Sbjct: 553 FSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLH 612
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE 439
C D + T A+D RV+L ++ EE
Sbjct: 613 -CSRLDDHAL-TGASDS--RVILWKDVTEAEQAEE 643
Score = 60.9 bits (141), Expect = 1e-08
Identities = 37/151 (24%), Positives = 77/151 (50%), Gaps = 2/151 (1%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I SVA +P+ + +A+G++ + L+ + Q ++L H + + + FSP ++LA+A
Sbjct: 480 KDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 539
Query: 377 SNDGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLH 435
S DG + ++ ++ + L+ H + V F G ++ +S +DG +++ ++ +
Sbjct: 540 SADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVR 599
Query: 436 TFEEHTHIVCGVQFN-ADGSKLVSVSKDKSI 465
T + H V G+ + D L S + I
Sbjct: 600 TLDAHEDKVWGLHCSRLDDHALTGASDSRVI 630
Score = 56.8 bits (131), Expect = 2e-07
Identities = 47/178 (26%), Positives = 82/178 (46%), Gaps = 5/178 (2%)
Query: 297 KVTVYGIINGTVDKVLDTRGKF-IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+V + + +G V + L+ + I + SPD + + + + + +G + +
Sbjct: 46 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWK 105
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVS-VCFSPDGQR 413
A H V ++AF P + LLA+ DG V V++I + V V F PD R
Sbjct: 106 AIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTR 165
Query: 414 MA--TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ +SA D +IRV L++ L H V + F+ADG ++S +DK I++
Sbjct: 166 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
Score = 54.0 bits (124), Expect = 1e-06
Identities = 38/153 (24%), Positives = 73/153 (47%), Gaps = 2/153 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D+ ++ +P+ K + +GS ++ + + V + V +SP + +A+ +
Sbjct: 481 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 540
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDDGHMKLYDVVHANLAG 126
DG I ++ + + T EGH S+ + F S +QLL +GS DG +KL+ + +
Sbjct: 541 ADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGS-DGLVKLWTIKNNECVR 599
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL H V + S ++G++D V +W
Sbjct: 600 TLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 44.8 bits (101), Expect = 7e-04
Identities = 38/170 (22%), Positives = 70/170 (41%), Gaps = 4/170 (2%)
Query: 224 LLHTLEGHEMP-VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT-DSSDMWKIV 281
+L +LE + + + +SPD E + G R + ++ + +
Sbjct: 57 VLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMA 116
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA--SGAEGGS 339
F P + +ATGG G V V+ I+ + VA+ PD + S A +
Sbjct: 117 FDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAA 176
Query: 340 VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES 389
+ ++ + L + AH AV SLAFS + S+ D +++++S
Sbjct: 177 IRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 226
>BC007620-1|AAH07620.1| 570|Homo sapiens TBL3 protein protein.
Length = 570
Score = 87.8 bits (208), Expect = 7e-17
Identities = 43/128 (33%), Positives = 71/128 (55%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
SVA +P+ K +A+G+ D ++ + Q +L+ GH + + FSP Q+L T S DG
Sbjct: 246 SVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADG 305
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+KL+ + + T GH + VL VAF G + +S +D V++W + + +C T
Sbjct: 306 TIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDA 365
Query: 173 HNDQVWGV 180
H D+VWG+
Sbjct: 366 HEDKVWGL 373
Score = 81.8 bits (193), Expect = 5e-15
Identities = 48/144 (33%), Positives = 71/144 (49%), Gaps = 16/144 (11%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H I S+ +P+ +LL TGS D KL+ + L G SGH + V FSP +
Sbjct: 240 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 299
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ SAD T+++W L C TF+ H+ V V F + +++S G
Sbjct: 300 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLS--------------SGS 345
Query: 209 DNLVKVWSYENNKLELLHTLEGHE 232
D LVK+W+ +NN E + TL+ HE
Sbjct: 346 DGLVKLWTIKNN--ECVRTLDAHE 367
Score = 64.9 bits (151), Expect = 6e-10
Identities = 38/117 (32%), Positives = 62/117 (52%), Gaps = 1/117 (0%)
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T H + + S+A +P KLLA+ S D ++ + L H+ V FSP
Sbjct: 236 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMD 295
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +AT++ADG+I++ L++F L TFE H V V F + G++L+S D + ++
Sbjct: 296 QVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 352
Score = 61.3 bits (142), Expect = 7e-09
Identities = 78/395 (19%), Positives = 154/395 (38%), Gaps = 25/395 (6%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLE---GHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
G Y + G + +++ A G+ V+T G + + + ++LT + D ++ L
Sbjct: 21 GLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLL 80
Query: 117 YDVVHANLAGTLSGHASWVLSVAF-SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHND 175
Y+ L +G++ VL V F P+ V S ++V++L + CQ H D
Sbjct: 81 YEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTD 139
Query: 176 QVWGVKFNAESNKIISVSEDKG--------PSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
V + + S ++D+ + V G + V + ++L+
Sbjct: 140 IVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFL 199
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGS 287
+ G + V + P Q+ + D+ + +P+
Sbjct: 200 VTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHD-----KDINSVAIAPNDK 254
Query: 288 QVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQ 347
+ATG ++ + + V + + V +SP + +A+ + G++ L+ +
Sbjct: 255 LLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQD 314
Query: 348 GKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWAVS 404
L T E H +V +AF + L S+ +DG V ++ I++ LD K W +
Sbjct: 315 FSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLH 374
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE 439
C D + T A+D RV+L ++ EE
Sbjct: 375 -CSRLDDHAL-TGASDS--RVILWKDVTEAEQAEE 405
Score = 60.9 bits (141), Expect = 1e-08
Identities = 37/151 (24%), Positives = 77/151 (50%), Gaps = 2/151 (1%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I SVA +P+ + +A+G++ + L+ + Q ++L H + + + FSP ++LA+A
Sbjct: 242 KDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 301
Query: 377 SNDGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLH 435
S DG + ++ ++ + L+ H + V F G ++ +S +DG +++ ++ +
Sbjct: 302 SADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVR 361
Query: 436 TFEEHTHIVCGVQFN-ADGSKLVSVSKDKSI 465
T + H V G+ + D L S + I
Sbjct: 362 TLDAHEDKVWGLHCSRLDDHALTGASDSRVI 392
Score = 54.0 bits (124), Expect = 1e-06
Identities = 38/153 (24%), Positives = 73/153 (47%), Gaps = 2/153 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D+ ++ +P+ K + +GS ++ + + V + V +SP + +A+ +
Sbjct: 243 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 302
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDDGHMKLYDVVHANLAG 126
DG I ++ + + T EGH S+ + F S +QLL +GS DG +KL+ + +
Sbjct: 303 ADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGS-DGLVKLWTIKNNECVR 361
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL H V + S ++G++D V +W
Sbjct: 362 TLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 394
>AF083383-1|AAC64084.1| 310|Homo sapiens 38kDa splicing factor
protein.
Length = 310
Score = 87.8 bits (208), Expect = 7e-17
Identities = 66/250 (26%), Positives = 113/250 (45%), Gaps = 25/250 (10%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKFTLSVAYSPDGKYIASG 66
+V+ F P+G + S IL++ V L + + Y+ DG + S
Sbjct: 9 EVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSA 68
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSP--DSQLLLTGSDDGHMKLYDVVHANL 124
+ D + ++D G+ V L+GH + S C+ QL+ TGSDDG +KL+D+
Sbjct: 69 STDKTVAVWDSETGERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTVKLWDIRKKAA 127
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T + VL+V F+ + +SG D ++VWDL + +T + H D V G+ ++
Sbjct: 128 VQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS 186
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE--NNKLELLHTLEGH----EMPVVSV 238
E + Y+++ +DN V+VW K + +G+ E ++
Sbjct: 187 EGS--------------YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC 232
Query: 239 AVSPDGETIA 248
+ SPDG IA
Sbjct: 233 SWSPDGSKIA 242
Score = 73.7 bits (173), Expect = 1e-12
Identities = 44/151 (29%), Positives = 74/151 (49%), Gaps = 9/151 (5%)
Query: 21 VISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFDVAQG 80
V +GS+ G + ++ + Q + L+V ++ I SG +D I ++D+ Q
Sbjct: 108 VCTGSDDGTVKLWDIRKKAAVQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQN 166
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV--------VHANLAGTLSGHA 132
KL +T+ GHA S+ L S + LL+ + D ++++DV G +
Sbjct: 167 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 226
Query: 133 SWVLSVAFSPDGKRFVSGSADRTVRVWDLDS 163
+L ++SPDG + +GSADR V VWD S
Sbjct: 227 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTS 257
Score = 64.5 bits (150), Expect = 8e-10
Identities = 50/238 (21%), Positives = 104/238 (43%), Gaps = 12/238 (5%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P+ + + G D L+ +W+ + + TL+GH V+ + + DG +
Sbjct: 17 PNGSTLASAGFDRLILLWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 75
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ-VATGGHTGKVTVYGIINGTVDKVLDTRG 316
G++++ ++ +S + + G Q V TG G V ++ I +
Sbjct: 76 VWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAVQTFQNTY 135
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
+ +++V ++ I SG + ++D+ Q K+ +T+ HA +V L+ S + L S
Sbjct: 136 Q-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN 194
Query: 377 SNDGYVNVYNIESAALQ---------NKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
+ D V V+++ A + N + + + +SPDG ++A +AD + V
Sbjct: 195 AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYV 252
Score = 51.2 bits (117), Expect = 8e-06
Identities = 50/253 (19%), Positives = 107/253 (42%), Gaps = 12/253 (4%)
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXG-QKIREIQTDSSDMWKIVFSPDG 286
L GHE V P+G T+A ++ S + ++ ++ DG
Sbjct: 3 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 62
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDG-RYIASGAEGGSVYLFDV 345
S + + V V+ G K L F+ S + G + + +G++ G+V L+D+
Sbjct: 63 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 122
Query: 346 SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVS 404
+ + T + + V ++ F+ + + S D + V+++ L + H
Sbjct: 123 RKKAAVQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 181
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEF----RVLHTFEEHTH----IVCGVQFNADGSKL 456
+ S +G + ++A D ++RV + F R + F+ + H + ++ DGSK+
Sbjct: 182 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI 241
Query: 457 VSVSKDKSINIYE 469
+ S D+ + +++
Sbjct: 242 AAGSADRFVYVWD 254
Score = 51.2 bits (117), Expect = 8e-06
Identities = 46/220 (20%), Positives = 84/220 (38%), Gaps = 19/220 (8%)
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQH--TFKEHNDQVWGVKFNAE 185
LSGH V F P+G S DR + +W++ C + T K H+ V + +N +
Sbjct: 3 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG-DCDNYATLKGHSGAVMELHYNTD 61
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
+ + S S DK V VW E E + L+GH V S + G
Sbjct: 62 GSMLFSASTDK--------------TVAVWDSETG--ERVKRLKGHTSFVNSCYPARRGP 105
Query: 246 TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIIN 305
+ + + ++ + + F+ Q+ +GG + V+ +
Sbjct: 106 QLVCTGSDDGTVKLWDIRKKAAVQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 165
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV 345
+ + + ++ S +G Y+ S A +V ++DV
Sbjct: 166 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV 205
Score = 36.3 bits (80), Expect = 0.24
Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 13/150 (8%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V + F+ +ISG I ++ + K + ++ S +G Y+ S A+
Sbjct: 137 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 196
Query: 69 DGIINIFDV----AQGKLVHTLEGHA----MSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
D + ++DV + + V +G+ ++ +SPD + GS D + ++D
Sbjct: 197 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 256
Query: 121 H----ANLAGTLSGHASWVLSVAFSPDGKR 146
+ TL+ W LS SP +
Sbjct: 257 SRRSCTSCLVTLAPSMKW-LSTPTSPSSSQ 285
>AB209173-1|BAD92410.1| 832|Homo sapiens transducin beta-like 3
variant protein.
Length = 832
Score = 87.8 bits (208), Expect = 7e-17
Identities = 43/128 (33%), Positives = 71/128 (55%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
SVA +P+ K +A+G+ D ++ + Q +L+ GH + + FSP Q+L T S DG
Sbjct: 508 SVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADG 567
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKE 172
+KL+ + + T GH + VL VAF G + +S +D V++W + + +C T
Sbjct: 568 TIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDA 627
Query: 173 HNDQVWGV 180
H D+VWG+
Sbjct: 628 HEDKVWGL 635
Score = 85.0 bits (201), Expect = 5e-16
Identities = 99/488 (20%), Positives = 196/488 (40%), Gaps = 34/488 (6%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASG 66
D+ D SPD + +++ S A + + + G ++ ++ +A+ P +A+G
Sbjct: 92 DITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATG 151
Query: 67 ALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ--LLLTGSDDGHMKLYDVVHANL 124
DG + ++D+ + H G + + F PD LL + + D ++++ + +
Sbjct: 152 GCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSC 211
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
L+ H S V S+AFS DG +S D+ +WDL S Q T V
Sbjct: 212 LAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPE 271
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTL---EGHEMPVVSVAVS 241
E + V K P Y +T G ++VW + + G E+ ++A +
Sbjct: 272 EPVSQLGV---KSPGL-YFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGRELTHCTLAHT 327
Query: 242 PDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVF-SPDGSQVATGGHTGKVTV 300
A QK + S ++ + F P+ S V ++ + V
Sbjct: 328 AGVVLTATADHNLLLYEARSLRLQK--QFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKV 385
Query: 301 YGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI---EAH 357
+ + + ++L ++++ G AS A+ SV ++ +++ + + H
Sbjct: 386 FE-LQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGH 444
Query: 358 AQAVRSLAFSP-KTKLLASASNDGYVNVYNIESA-------------ALQNKLDHKCW-- 401
+V ++ S K L + S D V ++ + A LQ + +C
Sbjct: 445 THSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLPKNTAPDNGPILLQAQTTQRCHDK 504
Query: 402 -AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVS 460
SV +P+ + +AT + D + ++ L + ++L F H + VQF+ L + S
Sbjct: 505 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 564
Query: 461 KDKSINIY 468
D +I ++
Sbjct: 565 ADGTIKLW 572
Score = 81.8 bits (193), Expect = 5e-15
Identities = 48/144 (33%), Positives = 71/144 (49%), Gaps = 16/144 (11%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H I S+ +P+ +LL TGS D KL+ + L G SGH + V FSP +
Sbjct: 502 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 561
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGL 208
+ SAD T+++W L C TF+ H+ V V F + +++S G
Sbjct: 562 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLS--------------SGS 607
Query: 209 DNLVKVWSYENNKLELLHTLEGHE 232
D LVK+W+ +NN E + TL+ HE
Sbjct: 608 DGLVKLWTIKNN--ECVRTLDAHE 629
Score = 64.9 bits (151), Expect = 6e-10
Identities = 38/117 (32%), Positives = 62/117 (52%), Gaps = 1/117 (0%)
Query: 353 TIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
T H + + S+A +P KLLA+ S D ++ + L H+ V FSP
Sbjct: 498 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMD 557
Query: 412 QRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
Q +AT++ADG+I++ L++F L TFE H V V F + G++L+S D + ++
Sbjct: 558 QVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 614
Score = 60.9 bits (141), Expect = 1e-08
Identities = 62/337 (18%), Positives = 133/337 (39%), Gaps = 9/337 (2%)
Query: 63 IASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDDGHMKLYDVVH 121
+ + D + +++ +L G++ + + F P+ ++ S+ +K++++
Sbjct: 331 VLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFEL-Q 389
Query: 122 ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLD---SMQCQHTFKEHNDQVW 178
+ L GH VL++ G F S + D++VR+W ++ + C H V
Sbjct: 390 TSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVG 449
Query: 179 GVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK--LELLHTLEGHEMPVV 236
V + + K + + L L K + +N L+ T H+ +
Sbjct: 450 TVCCSRLKESFLVTGSQDCTVKLWPLPKAL--LPKNTAPDNGPILLQAQTTQRCHDKDIN 507
Query: 237 SVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTG 296
SVA++P+ + +A Q + +W + FSP +AT G
Sbjct: 508 SVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADG 567
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEA 356
+ ++ + + + K + ++ VA+ G + S G V L+ + + + T++A
Sbjct: 568 TIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDA 627
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQ 393
H V L S + ++D V ++ + A Q
Sbjct: 628 HEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQ 664
Score = 60.9 bits (141), Expect = 1e-08
Identities = 37/151 (24%), Positives = 77/151 (50%), Gaps = 2/151 (1%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I SVA +P+ + +A+G++ + L+ + Q ++L H + + + FSP ++LA+A
Sbjct: 504 KDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 563
Query: 377 SNDGYVNVYNIES-AALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLH 435
S DG + ++ ++ + L+ H + V F G ++ +S +DG +++ ++ +
Sbjct: 564 SADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVR 623
Query: 436 TFEEHTHIVCGVQFN-ADGSKLVSVSKDKSI 465
T + H V G+ + D L S + I
Sbjct: 624 TLDAHEDKVWGLHCSRLDDHALTGASDSRVI 654
Score = 60.5 bits (140), Expect = 1e-08
Identities = 78/395 (19%), Positives = 154/395 (38%), Gaps = 25/395 (6%)
Query: 60 GKYIASGALDGIINIFDVAQGKLVHTLE---GHAMSIRSLCFSPDSQLLLTGSDDGHMKL 116
G Y + G + +++ A G+ V+T G + + + ++LT + D ++ L
Sbjct: 283 GLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGRELTHCTLAHTAGVVLTATADHNLLL 342
Query: 117 YDVVHANLAGTLSGHASWVLSVAF-SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHND 175
Y+ L +G++ VL V F P+ V S ++V++L + CQ H D
Sbjct: 343 YEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTD 401
Query: 176 QVWGVKFNAESNKIISVSEDKG--------PSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
V + + S ++D+ + V G + V + ++L+
Sbjct: 402 IVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFL 461
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGS 287
+ G + V + P Q+ + D+ + +P+
Sbjct: 462 VTGSQDCTVKLWPLPKALLPKNTAPDNGPILLQAQTTQRCHD-----KDINSVAIAPNDK 516
Query: 288 QVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQ 347
+ATG ++ + + V + + V +SP + +A+ + G++ L+ +
Sbjct: 517 LLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQD 576
Query: 348 GKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLD---HKCWAVS 404
L T E H +V +AF + L S+ +DG V ++ I++ LD K W +
Sbjct: 577 FSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLH 636
Query: 405 VCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEE 439
C D + T A+D RV+L ++ EE
Sbjct: 637 -CSRLDDHAL-TGASDS--RVILWKDVTEAEQAEE 667
Score = 56.8 bits (131), Expect = 2e-07
Identities = 47/178 (26%), Positives = 82/178 (46%), Gaps = 5/178 (2%)
Query: 297 KVTVYGIINGTVDKVLDTRGKF-IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+V + + +G V + L+ + I + SPD + + + + + +G + +
Sbjct: 70 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWK 129
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVS-VCFSPDGQR 413
A H V ++AF P + LLA+ DG V V++I + V V F PD R
Sbjct: 130 AIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTR 189
Query: 414 MA--TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ +SA D +IRV L++ L H V + F+ADG ++S +DK I++
Sbjct: 190 LLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 247
Score = 54.0 bits (124), Expect = 1e-06
Identities = 38/153 (24%), Positives = 73/153 (47%), Gaps = 2/153 (1%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
D+ ++ +P+ K + +GS ++ + + V + V +SP + +A+ +
Sbjct: 505 DINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATAS 564
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCF-SPDSQLLLTGSDDGHMKLYDVVHANLAG 126
DG I ++ + + T EGH S+ + F S +QLL +GS DG +KL+ + +
Sbjct: 565 ADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGS-DGLVKLWTIKNNECVR 623
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL H V + S ++G++D V +W
Sbjct: 624 TLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 656
Score = 44.8 bits (101), Expect = 7e-04
Identities = 38/170 (22%), Positives = 70/170 (41%), Gaps = 4/170 (2%)
Query: 224 LLHTLEGHEMP-VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQT-DSSDMWKIV 281
+L +LE + + + +SPD E + G R + ++ + +
Sbjct: 81 VLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMA 140
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIA--SGAEGGS 339
F P + +ATGG G V V+ I+ + VA+ PD + S A +
Sbjct: 141 FDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAA 200
Query: 340 VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIES 389
+ ++ + L + AH AV SLAFS + S+ D +++++S
Sbjct: 201 IRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQS 250
>BC014988-1|AAH14988.1| 919|Homo sapiens PWP2 periodic tryptophan
protein homolog (yeast) protein.
Length = 919
Score = 87.4 bits (207), Expect = 1e-16
Identities = 82/325 (25%), Positives = 138/325 (42%), Gaps = 37/325 (11%)
Query: 53 SVAYSPDGKYIASGALD-GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDD 111
SVA + G +IA G G + +++ V +GH S+ +L +SPD Q ++TG DD
Sbjct: 335 SVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDD 394
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
G +K+++ + T + H+S V V F+ G V+ S D TVR +DL + TF
Sbjct: 395 GKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNL-VKVWSYENNKLELLHTLEG 230
+ + V+ D S + + G D+ + VWS + + LL L G
Sbjct: 455 -----------SPRPTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGR--LLDVLSG 499
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
HE P+ + +P +A + +E +SD + PDG+++A
Sbjct: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTIRPDGAELA 559
Query: 291 TGGHTGKVTVY--------GIINGTVD-----KVLD-------TRGKFIMSVAWSPDGRY 330
++T + G I G D K LD +GK ++ +S DG
Sbjct: 560 VATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHS 619
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIE 355
I +G V ++ V + ++ E
Sbjct: 620 ILAGGMSKFVCIYHVREQILMKRFE 644
Score = 75.8 bits (178), Expect = 3e-13
Identities = 98/479 (20%), Positives = 202/479 (42%), Gaps = 24/479 (5%)
Query: 9 VWTLDFSPDG-KHVISGSNAGKILIF-GVESGKQEQVLDTR--GKF--TLSVAYSPDGKY 62
V ++ FSPDG K V++ N ++ G + VLD G + T + ++ D +
Sbjct: 99 VHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRC 158
Query: 63 IASGALDGIINIFDVAQ--GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
G+ D +F + + + L GH +I + F +S L + S DG + ++
Sbjct: 159 FVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCD 218
Query: 121 HANLAGTLSGHASW---VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
L A W +L + + G + T+R + + + T K ++
Sbjct: 219 TPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEE-EKTGKVKYSRL 277
Query: 178 WGVKFNAES--NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPV 235
FN E N + + + K +VTG + + +E + L+H+L + +
Sbjct: 278 AKYFFNKEGDFNNLTAAAFHK--KSHLLVTGFASGIFHL--HELPEFNLIHSLSISDQSI 333
Query: 236 VSVAVSPDGETIAXXXXXXXXXXXXXXXGQK-IREIQTDSSDMWKIVFSPDGSQVATGGH 294
SVA++ G+ IA + + + Q + M + +SPDG + TGG
Sbjct: 334 ASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGD 393
Query: 295 TGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI 354
GKV V+ ++G + V ++ G + + + G+V FD+ + + T
Sbjct: 394 DGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTF 453
Query: 355 EAHAQAVRS-LAFSPKTKLLASASNDGY-VNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
+ S +A +++++ + D + + V+++++ L + L H+ +CF+P
Sbjct: 454 TSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
Query: 412 QRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+A+++ D ++R+ + + +R T T V DG++L + + I ++
Sbjct: 514 SVLASASWDKTVRLWDMFDSWRTKETL-ALTSDALAVTIRPDGAELAVATLNSQITFWD 571
Score = 37.1 bits (82), Expect = 0.14
Identities = 43/193 (22%), Positives = 80/193 (41%), Gaps = 14/193 (7%)
Query: 297 KVTVYGIINGTVDKV-LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+VTV+ + N D + L TR + V SPDGR EGG L + +LH
Sbjct: 36 RVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFH 94
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE------SAALQNKLDHKCWAVSVC--F 407
+V S++FSP + + +Y+ +A + +K + + C +
Sbjct: 95 FKG-SVHSVSFSPDGRKFV-VTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDW 152
Query: 408 SPDGQRMATSAADGSIRVVLLEEF--RVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSI 465
+ D + + D S V E + + + H + F ++ L S+S+D +
Sbjct: 153 TDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVL 212
Query: 466 NIYECPIPPKSAK 478
+++C PP+ +
Sbjct: 213 CMWQCDTPPEGLR 225
>BC013309-1|AAH13309.1| 919|Homo sapiens PWP2 periodic tryptophan
protein homolog (yeast) protein.
Length = 919
Score = 87.4 bits (207), Expect = 1e-16
Identities = 82/325 (25%), Positives = 138/325 (42%), Gaps = 37/325 (11%)
Query: 53 SVAYSPDGKYIASGALD-GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDD 111
SVA + G +IA G G + +++ V +GH S+ +L +SPD Q ++TG DD
Sbjct: 335 SVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDD 394
Query: 112 GHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFK 171
G +K+++ + T + H+S V V F+ G V+ S D TVR +DL + TF
Sbjct: 395 GKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Query: 172 EHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNL-VKVWSYENNKLELLHTLEG 230
+ + V+ D S + + G D+ + VWS + + LL L G
Sbjct: 455 -----------SPRPTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGR--LLDVLSG 499
Query: 231 HEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVA 290
HE P+ + +P +A + +E +SD + PDG+++A
Sbjct: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTIRPDGAELA 559
Query: 291 TGGHTGKVTVY--------GIINGTVD-----KVLD-------TRGKFIMSVAWSPDGRY 330
++T + G I G D K LD +GK ++ +S DG
Sbjct: 560 VATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHS 619
Query: 331 IASGAEGGSVYLFDVSQGKMLHTIE 355
I +G V ++ V + ++ E
Sbjct: 620 ILAGGMSKFVCIYHVREQILMKRFE 644
Score = 75.8 bits (178), Expect = 3e-13
Identities = 98/479 (20%), Positives = 202/479 (42%), Gaps = 24/479 (5%)
Query: 9 VWTLDFSPDG-KHVISGSNAGKILIF-GVESGKQEQVLDTR--GKF--TLSVAYSPDGKY 62
V ++ FSPDG K V++ N ++ G + VLD G + T + ++ D +
Sbjct: 99 VHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRC 158
Query: 63 IASGALDGIINIFDVAQ--GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
G+ D +F + + + L GH +I + F +S L + S DG + ++
Sbjct: 159 FVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCD 218
Query: 121 HANLAGTLSGHASW---VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
L A W +L + + G + T+R + + + T K ++
Sbjct: 219 TPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEE-EKTGKVKYSRL 277
Query: 178 WGVKFNAES--NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPV 235
FN E N + + + K +VTG + + +E + L+H+L + +
Sbjct: 278 AKYFFNKEGDFNNLTAAAFHK--KSHLLVTGFASGIFHL--HELPEFNLIHSLSISDQSI 333
Query: 236 VSVAVSPDGETIAXXXXXXXXXXXXXXXGQK-IREIQTDSSDMWKIVFSPDGSQVATGGH 294
SVA++ G+ IA + + + Q + M + +SPDG + TGG
Sbjct: 334 ASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGD 393
Query: 295 TGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI 354
GKV V+ ++G + V ++ G + + + G+V FD+ + + T
Sbjct: 394 DGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTF 453
Query: 355 EAHAQAVRS-LAFSPKTKLLASASNDGY-VNVYNIESAALQNKLD-HKCWAVSVCFSPDG 411
+ S +A +++++ + D + + V+++++ L + L H+ +CF+P
Sbjct: 454 TSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
Query: 412 QRMATSAADGSIRV-VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+A+++ D ++R+ + + +R T T V DG++L + + I ++
Sbjct: 514 SVLASASWDKTVRLWDMFDSWRTKETL-ALTSDALAVTIRPDGAELAVATLNSQITFWD 571
Score = 37.1 bits (82), Expect = 0.14
Identities = 43/193 (22%), Positives = 80/193 (41%), Gaps = 14/193 (7%)
Query: 297 KVTVYGIINGTVDKV-LDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
+VTV+ + N D + L TR + V SPDGR EGG L + +LH
Sbjct: 36 RVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFH 94
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE------SAALQNKLDHKCWAVSVC--F 407
+V S++FSP + + +Y+ +A + +K + + C +
Sbjct: 95 FKG-SVHSVSFSPDGRKFV-VTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDW 152
Query: 408 SPDGQRMATSAADGSIRVVLLEEF--RVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSI 465
+ D + + D S V E + + + H + F ++ L S+S+D +
Sbjct: 153 TDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVL 212
Query: 466 NIYECPIPPKSAK 478
+++C PP+ +
Sbjct: 213 CMWQCDTPPEGLR 225
>AK090597-1|BAC03485.1| 513|Homo sapiens protein ( Homo sapiens
cDNA FLJ33278 fis, clone ASTRO2008508, weakly similar to
TIPD PROTEIN. ).
Length = 513
Score = 87.4 bits (207), Expect = 1e-16
Identities = 89/345 (25%), Positives = 144/345 (41%), Gaps = 34/345 (9%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESG-----KQEQVLDTRGKFTLSVAYSPDGKYIASG 66
LDF H I G+ + I V + + VLD +V + P+ +A+G
Sbjct: 189 LDFKKRRGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVGFGPNSSLLATG 248
Query: 67 ALDGIINIFDVAQGKLV--HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
D +I++++V +L TLEG SI S+ F P +L + + +L+ V A
Sbjct: 249 GADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQS 308
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT---FKEHNDQVWG-- 179
TLSGH V + F + V+GS DRTV+ WDL C T ND V G
Sbjct: 309 KETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDH 368
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ + +++ I + +GP ++ + V S +++L LL + + V+ +
Sbjct: 369 IIISGHNDQKIRFWDSRGPHCTQVIP--VQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLR 426
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
VS + G K SD K VFSPD S G G +
Sbjct: 427 VSNIRQVF-------------RADGFKC------GSDWTKAVFSPDRSYALAGSCDGALY 467
Query: 300 VYGIINGTVDKVLD-TRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
++ + G ++ L + +VAW G ++ S +G V L+
Sbjct: 468 IWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 512
Score = 54.8 bits (126), Expect = 6e-07
Identities = 59/280 (21%), Positives = 106/280 (37%), Gaps = 12/280 (4%)
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
GP+ + TGG D L+ +W+ ++LE TLEG + SV P G +
Sbjct: 239 GPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAA 298
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
Q + + F Q TG V + + + ++
Sbjct: 299 QLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVL- 357
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
+ V I SG + +D S+G + V SL+ S L S
Sbjct: 358 SYCNDVVCG--DHIIISGHNDQKIRFWD-SRGPHCTQVIPVQGRVTSLSLSHDQLHLLSC 414
Query: 377 SNDGYVNVYNIESAALQN--KLD-HKC---WAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
S D + V ++ + ++ + D KC W +V FSPD + DG++ + ++
Sbjct: 415 SRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAV-FSPDRSYALAGSCDGALYIWDVDT 473
Query: 431 FRVLHTFE-EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ + H V V + GS +VSV + + + +++
Sbjct: 474 GKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 513
Score = 42.3 bits (95), Expect = 0.004
Identities = 25/119 (21%), Positives = 59/119 (49%), Gaps = 3/119 (2%)
Query: 354 IEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQ--NKLDHKCWAV-SVCFSPD 410
++AH V ++ F P + LLA+ D ++++N+ + L+ L+ ++ SV F P
Sbjct: 226 LDAHLSEVNAVGFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 285
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G ++ + + + ++ + E + T H V +F + V+ S+D+++ ++
Sbjct: 286 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 344
Score = 41.1 bits (92), Expect = 0.008
Identities = 25/118 (21%), Positives = 52/118 (44%), Gaps = 2/118 (1%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD--KVLDTRGKFIMSVAWSPDGRYIA 332
S++ + F P+ S +ATGG + ++ ++ ++ + L+ G I SV + P G +
Sbjct: 231 SEVNAVGFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVL 290
Query: 333 SGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA 390
+ + L+ V + + T+ H V + F + S D V +++ A
Sbjct: 291 AATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 348
Score = 41.1 bits (92), Expect = 0.008
Identities = 30/99 (30%), Positives = 49/99 (49%), Gaps = 9/99 (9%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG-----KFTLSVAYSPDGKYI 63
V +L S D H++S S + + + QV G +T +V +SPD Y
Sbjct: 399 VTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAV-FSPDRSYA 457
Query: 64 ASGALDGIINIFDVAQGKLVHTLEG-HAMSIRSL--CFS 99
+G+ DG + I+DV GKL L+G H ++ ++ C+S
Sbjct: 458 LAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYS 496
Score = 31.1 bits (67), Expect = 9.0
Identities = 23/117 (19%), Positives = 53/117 (45%), Gaps = 3/117 (2%)
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVRSLAFSP 368
VLD + +V + P+ +A+G ++L++V S+ + T+E ++ S+ F P
Sbjct: 225 VLDAHLSEVNAVGFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDP 284
Query: 369 KTKLLASASNDGYVNVYNIESAALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIR 424
+ +A+ + ++ + A + L HK + F + T + D +++
Sbjct: 285 SGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVK 341
>BC036713-1|AAH36713.1| 542|Homo sapiens ATG16L2 protein protein.
Length = 542
Score = 87.0 bits (206), Expect = 1e-16
Identities = 89/345 (25%), Positives = 144/345 (41%), Gaps = 34/345 (9%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESG-----KQEQVLDTRGKFTLSVAYSPDGKYIASG 66
LDF H I G+ + I V + + VLD +V + P+ +A+G
Sbjct: 218 LDFKKRRGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATG 277
Query: 67 ALDGIINIFDVAQGKLV--HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
D +I++++V +L TLEG SI S+ F P +L + + +L+ V A
Sbjct: 278 GADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQS 337
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHT---FKEHNDQVWG-- 179
TLSGH V + F + V+GS DRTV+ WDL C T ND V G
Sbjct: 338 KETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDH 397
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
+ + +++ I + +GP ++ + V S +++L LL + + V+ +
Sbjct: 398 IIISGHNDQKIRFWDSRGPHCTQVIP--VQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLR 455
Query: 240 VSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVT 299
VS + G K SD K VFSPD S G G +
Sbjct: 456 VSNIRQVF-------------RADGFKC------GSDWTKAVFSPDRSYALAGSCDGALY 496
Query: 300 VYGIINGTVDKVLD-TRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
++ + G ++ L + +VAW G ++ S +G V L+
Sbjct: 497 IWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 541
Score = 54.8 bits (126), Expect = 6e-07
Identities = 59/280 (21%), Positives = 106/280 (37%), Gaps = 12/280 (4%)
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
GP+ + TGG D L+ +W+ ++LE TLEG + SV P G +
Sbjct: 268 GPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAA 327
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
Q + + F Q TG V + + + ++
Sbjct: 328 QLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVL- 386
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
+ V I SG + +D S+G + V SL+ S L S
Sbjct: 387 SYCNDVVCG--DHIIISGHNDQKIRFWD-SRGPHCTQVIPVQGRVTSLSLSHDQLHLLSC 443
Query: 377 SNDGYVNVYNIESAALQN--KLD-HKC---WAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
S D + V ++ + ++ + D KC W +V FSPD + DG++ + ++
Sbjct: 444 SRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAV-FSPDRSYALAGSCDGALYIWDVDT 502
Query: 431 FRVLHTFE-EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ + H V V + GS +VSV + + + +++
Sbjct: 503 GKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 542
Score = 41.9 bits (94), Expect = 0.005
Identities = 25/119 (21%), Positives = 59/119 (49%), Gaps = 3/119 (2%)
Query: 354 IEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQ--NKLDHKCWAV-SVCFSPD 410
++AH V ++ F P + LLA+ D ++++N+ + L+ L+ ++ SV F P
Sbjct: 255 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 314
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G ++ + + + ++ + E + T H V +F + V+ S+D+++ ++
Sbjct: 315 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 373
Score = 41.1 bits (92), Expect = 0.008
Identities = 25/118 (21%), Positives = 52/118 (44%), Gaps = 2/118 (1%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD--KVLDTRGKFIMSVAWSPDGRYIA 332
S++ + F P+ S +ATGG + ++ ++ ++ + L+ G I SV + P G +
Sbjct: 260 SEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVL 319
Query: 333 SGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA 390
+ + L+ V + + T+ H V + F + S D V +++ A
Sbjct: 320 AATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 377
Score = 41.1 bits (92), Expect = 0.008
Identities = 30/99 (30%), Positives = 49/99 (49%), Gaps = 9/99 (9%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG-----KFTLSVAYSPDGKYI 63
V +L S D H++S S + + + QV G +T +V +SPD Y
Sbjct: 428 VTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAV-FSPDRSYA 486
Query: 64 ASGALDGIINIFDVAQGKLVHTLEG-HAMSIRSL--CFS 99
+G+ DG + I+DV GKL L+G H ++ ++ C+S
Sbjct: 487 LAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYS 525
>AK093494-1|BAC04184.1| 476|Homo sapiens protein ( Homo sapiens
cDNA FLJ36175 fis, clone TESTI2026453, weakly similar to
PUTATIVE SERINE/THREONINE-PROTEIN KINASE PKWA (EC
2.7.1.-). ).
Length = 476
Score = 86.6 bits (205), Expect = 2e-16
Identities = 69/252 (27%), Positives = 120/252 (47%), Gaps = 11/252 (4%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLC-FSPDSQLLLTGSDDGHM 114
+SP G +AS + DG +++ G+++ +E + S +C FSPDS L +G+ DG +
Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
Query: 115 KLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHN 174
L++ L S + + AFSP+G FV+GS+ + VWD D M+C H+ K H+
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHD 180
Query: 175 DQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVW--SYEN---NKLELLHTLE 229
G+ S++ +S E +G + + G D VK+W S+ + +L+ TL
Sbjct: 181 ---LGITCCDFSSQPVSDGE-QGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLS 236
Query: 230 GHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQV 289
GH PV++ A S DG+ + + + + + F+P+ +
Sbjct: 237 GHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLL 296
Query: 290 ATGGHTGKVTVY 301
ATG V ++
Sbjct: 297 ATGSMDKTVNIW 308
Score = 77.8 bits (183), Expect = 8e-14
Identities = 68/287 (23%), Positives = 125/287 (43%), Gaps = 22/287 (7%)
Query: 203 IVTGGLDNLVKVWSYENNKLELLHT-LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXX 261
+ T LD ++++S + EL H+ L+ H V SP G +A
Sbjct: 25 LATCSLDKTIRLYSLRDFT-ELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNT 83
Query: 262 XXGQKIREIQTDSSDMWKIV-FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
GQ + ++ S ++ FSPD + +A+G G V ++ + + + + +
Sbjct: 84 ENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLA 143
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKL-------- 372
+ A+SP+G + +G+ G + ++D + + LH+ +AH + FS +
Sbjct: 144 ACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQF 202
Query: 373 --LASASNDGYVNVYNIESAAL-------QNKLDHKCWAVSVC-FSPDGQRMATSAADGS 422
LAS D V ++ + + ++ L C V C FS DGQ + + + D S
Sbjct: 203 FRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKS 262
Query: 423 IRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ V +LHT +HT V F + L + S DK++NI++
Sbjct: 263 VIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
Score = 75.4 bits (177), Expect = 4e-13
Identities = 59/222 (26%), Positives = 103/222 (46%), Gaps = 32/222 (14%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIIN 73
FSPD + SG+ G ++++ +S K + + + A+SP+G + +G+ G +
Sbjct: 105 FSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLT 164
Query: 74 IFDVAQGKLVHTLEGHAMSIRSLCFS--PDSQ--------LLLTGSDDGHMKLYDVVHAN 123
++D + +H+ + H + I FS P S L + D +K++ V +
Sbjct: 165 VWDDKM-RCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTH 223
Query: 124 LAG-------TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQ 176
+ G TLSGH + VL+ AFS DG+ VSGS D++V V+D ++ HT +H
Sbjct: 224 ILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRY 283
Query: 177 VWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYE 218
V F P+ + TG +D V +W ++
Sbjct: 284 VTTCAF--------------APNTLLLATGSMDKTVNIWQFD 311
Score = 67.7 bits (158), Expect = 8e-11
Identities = 34/94 (36%), Positives = 50/94 (53%), Gaps = 1/94 (1%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
K TL GH + + FS D Q+L++GS D + +YD N+ TL+ H +V + AF
Sbjct: 230 KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAF 289
Query: 141 SPDGKRFVSGSADRTVRVWDLD-SMQCQHTFKEH 173
+P+ +GS D+TV +W D CQ EH
Sbjct: 290 APNTLLLATGSMDKTVNIWQFDLETLCQARSTEH 323
Score = 66.1 bits (154), Expect = 3e-10
Identities = 82/331 (24%), Positives = 133/331 (40%), Gaps = 37/331 (11%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA--GTLSGHASWVLSV 138
KL+HTL H + FS LL T S D ++LY + L H V
Sbjct: 3 KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
Query: 139 AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGP 198
FSP G S S D T +W+ + N Q+ V S + V + P
Sbjct: 61 CFSPSGHILASCSTDGTTVLWNTE-----------NGQMLAV-MEQPSGSPVRVCQFS-P 107
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
+ +G D V +W+ ++ KL +++ + + A SP+G
Sbjct: 108 DSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSL--AACAFSPNGSFFVTGSSCGDLTV 165
Query: 259 XXXXX----GQKIREIQTDSSDMWKIVFSPDGSQ------VATGGHTGKVTVYGI----I 304
+K ++ D S DG Q +A+ G +V ++ + I
Sbjct: 166 WDDKMRCLHSEKAHDLGITCCDFSSQPVS-DGEQGLQFFRLASCGQDCQVKIWIVSFTHI 224
Query: 305 NGTVDKVLDTRGKF---IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAV 361
G K T +++ A+S DG+ + SG+ SV ++D + +LHT+ H + V
Sbjct: 225 LGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYV 284
Query: 362 RSLAFSPKTKLLASASNDGYVNVYNIESAAL 392
+ AF+P T LLA+ S D VN++ + L
Sbjct: 285 TTCAFAPNTLLLATGSMDKTVNIWQFDLETL 315
Score = 58.0 bits (134), Expect = 7e-08
Identities = 61/241 (25%), Positives = 102/241 (42%), Gaps = 21/241 (8%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVA-YSPDGKYIASGALDGII 72
FSP G + S S G +++ E+G+ V++ + V +SPD +ASGA DG +
Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
Query: 73 NIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD----VVHANLAGTL 128
+++ KL S+ + FSP+ +TGS G + ++D +H+ A L
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181
Query: 129 SGHASWVLSVAFSPDGK------RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKF 182
G S DG+ R S D V++W + ++ + G
Sbjct: 182 -GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSG--- 237
Query: 183 NAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSP 242
+ + S D +V+G +D V V Y+ N +LHTL H V + A +P
Sbjct: 238 HCAPVLACAFSHD----GQMLVSGSVDKSVIV--YDTNTENILHTLTQHTRYVTTCAFAP 291
Query: 243 D 243
+
Sbjct: 292 N 292
Score = 51.6 bits (118), Expect = 6e-06
Identities = 62/301 (20%), Positives = 121/301 (40%), Gaps = 37/301 (12%)
Query: 63 IASGALDGIINIFDVAQ-GKLVHT-LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+A+ +LD I ++ + +L H+ L+ H ++ CFSP +L + S DG L++
Sbjct: 25 LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTE 84
Query: 121 HANLAGTLSGHASWVLSVA-FSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWG 179
+ + + + + V FSPD SG+AD TV +W+ S + + +
Sbjct: 85 NGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAA 144
Query: 180 VKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVA 239
F+ P+ + VTG + VW ++K+ LH+ + H++ +
Sbjct: 145 CAFS--------------PNGSFFVTGSSCGDLTVW---DDKMRCLHSEKAHDLGITCCD 187
Query: 240 VS----PDGETIAXXXXXXX----------XXXXXXXXGQKIREIQTDSSDMWKIV---F 282
S DGE G +++ T S ++ F
Sbjct: 188 FSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAF 247
Query: 283 SPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYL 342
S DG + +G V VY + L +++ + A++P+ +A+G+ +V +
Sbjct: 248 SHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNI 307
Query: 343 F 343
+
Sbjct: 308 W 308
Score = 45.2 bits (102), Expect = 5e-04
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 6/124 (4%)
Query: 349 KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE--SAALQNKLDHKCWAV-SV 405
K++HT+ H V AFS LLA+ S D + +Y++ + + L +AV
Sbjct: 3 KLIHTLADHGDDVNCCAFS--FSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCC 60
Query: 406 CFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGV-QFNADGSKLVSVSKDKS 464
CFSP G +A+ + DG+ + E ++L E+ + V QF+ D + L S + D +
Sbjct: 61 CFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGT 120
Query: 465 INIY 468
+ ++
Sbjct: 121 VVLW 124
>AB209201-1|BAD92438.1| 466|Homo sapiens WD repeat-containing
protein 3 variant protein.
Length = 466
Score = 84.6 bits (200), Expect = 7e-16
Identities = 52/199 (26%), Positives = 92/199 (46%), Gaps = 11/199 (5%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQ-------VLDTR----GKFTLSVAYS 57
+W++ SPD + ++G + + E K E V TR + L V+YS
Sbjct: 22 LWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENRTQKRLSVKQTRTLQLDEDVLCVSYS 81
Query: 58 PDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLY 117
P+ K +A LD + IF V K +L GH + + + S D L+ TGS D ++K++
Sbjct: 82 PNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIW 141
Query: 118 DVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQV 177
+ + +L H V+ + F P F + D ++ WD D + T + H+ ++
Sbjct: 142 GLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEI 201
Query: 178 WGVKFNAESNKIISVSEDK 196
W + + + ++S S DK
Sbjct: 202 WCLAVSPSGDYVVSSSHDK 220
Score = 79.0 bits (186), Expect = 3e-14
Identities = 61/272 (22%), Positives = 119/272 (43%), Gaps = 9/272 (3%)
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
++LYD+ NL T+ H + S++ SPD + FV+G AD++V+ WD + ++ ++ ++
Sbjct: 1 LQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENRTQKR 60
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
V + ++ VS P++ + LD VK++ + K L +L GH++
Sbjct: 61 L-SVKQTRTLQLDEDVLCVS--YSPNQKLLAVSLLDCTVKIFYVDTLKFFL--SLYGHKL 115
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
PV+ + +S DG IA G + + + + F P T G
Sbjct: 116 PVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAG 175
Query: 294 HTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKML-- 351
K+ + + L+ + I +A SP G Y+ S + S+ L++ ++ ++
Sbjct: 176 KDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILE 235
Query: 352 --HTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+E A+ S+A + + D Y
Sbjct: 236 EEREMEREAEYEESVAKEDQPAVPGETQGDSY 267
Score = 62.9 bits (146), Expect = 2e-09
Identities = 45/153 (29%), Positives = 70/153 (45%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA 67
DV + +SP+ K + + IF V++ K L + + S DG IA+G+
Sbjct: 74 DVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGS 133
Query: 68 LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
D + I+ + G +L H S+ L F P S L T D +K +D T
Sbjct: 134 ADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQT 193
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
L GH + +A SP G VS S D+++R+W+
Sbjct: 194 LEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 226
Score = 55.2 bits (127), Expect = 5e-07
Identities = 53/217 (24%), Positives = 93/217 (42%), Gaps = 45/217 (20%)
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV------------ 119
+ ++D+A G L+ T++ H ++ S+ SPD + +TG D +K +D
Sbjct: 1 LQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENRTQKR 60
Query: 120 VHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDS---------------- 163
+ TL VL V++SP+ K D TV+++ +D+
Sbjct: 61 LSVKQTRTLQLDED-VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVIC 119
Query: 164 MQCQHT-------FKEHNDQVWGVKFNAESNKIISVSEDK------GPSKDYIVTGGLDN 210
M H + N ++WG+ F + +K + +D P T G D+
Sbjct: 120 MDISHDGALIATGSADRNVKIWGLDF-GDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDH 178
Query: 211 LVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+K W + +K E + TLEGH + +AVSP G+ +
Sbjct: 179 KIKQW--DADKFEHIQTLEGHHQEIWCLAVSPSGDYV 213
Score = 51.6 bits (118), Expect = 6e-06
Identities = 50/218 (22%), Positives = 88/218 (40%), Gaps = 12/218 (5%)
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGII-----NGTVDK--VLDTR- 315
G + I +W + SPD TGG V + N T + V TR
Sbjct: 9 GNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENRTQKRLSVKQTRT 68
Query: 316 ---GKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKL 372
+ ++ V++SP+ + +A +V +F V K ++ H V + S L
Sbjct: 69 LQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGAL 128
Query: 373 LASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEF 431
+A+ S D V ++ ++ L H + + F P T+ D I+ ++F
Sbjct: 129 IATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKF 188
Query: 432 RVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
+ T E H + + + G +VS S DKS+ ++E
Sbjct: 189 EHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 226
Score = 45.6 bits (103), Expect = 4e-04
Identities = 29/139 (20%), Positives = 66/139 (47%), Gaps = 12/139 (8%)
Query: 342 LFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCW 401
L+D++ G +L TI+AH A+ S++ SP + + D V ++ E +N+ +
Sbjct: 3 LYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENRTQKRLS 62
Query: 402 ------------AVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQF 449
+ V +SP+ + +A S D ++++ ++ + + H V +
Sbjct: 63 VKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDI 122
Query: 450 NADGSKLVSVSKDKSINIY 468
+ DG+ + + S D+++ I+
Sbjct: 123 SHDGALIATGSADRNVKIW 141
>AK093017-1|BAC04021.1| 619|Homo sapiens protein ( Homo sapiens
cDNA FLJ35698 fis, clone SPLEN2019839, weakly similar to
TIPD PROTEIN. ).
Length = 619
Score = 84.2 bits (199), Expect = 9e-16
Identities = 84/344 (24%), Positives = 136/344 (39%), Gaps = 32/344 (9%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESG-----KQEQVLDTRGKFTLSVAYSPDGKYIASG 66
LDF H I G+ + I V + + VLD +V + P+ +A+G
Sbjct: 295 LDFKKRRGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATG 354
Query: 67 ALDGIINIFDVAQGKLV--HTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
D +I++++V +L TLEG SI S+ F P +L + + +L+ V A
Sbjct: 355 GADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQS 414
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
TLSGH V + F + V+GS DRTV+ WDL C T
Sbjct: 415 KETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTI-------------- 460
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDG 244
++S D I++G D ++ W + ++G V S+++S D
Sbjct: 461 ---NVLSYCNDVVCGDHIIISGHNDQKIRFWDSREPHCTQVIPVQGR---VTSLSLSHDQ 514
Query: 245 ETIAXXXXXXXXXXXXXXXGQKIREIQTD----SSDMWKIVFSPDGSQVATGGHTGKVTV 300
+ + + D SD K VFSPD S G G + +
Sbjct: 515 LHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYI 574
Query: 301 YGIINGTVDKVLD-TRGKFIMSVAWSPDGRYIASGAEGGSVYLF 343
+ + G ++ L + +VAW G ++ S +G V L+
Sbjct: 575 WDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLW 618
Score = 55.6 bits (128), Expect = 4e-07
Identities = 58/280 (20%), Positives = 105/280 (37%), Gaps = 12/280 (4%)
Query: 197 GPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXX 256
GP+ + TGG D L+ +W+ ++LE TLEG + SV P G +
Sbjct: 345 GPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAA 404
Query: 257 XXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRG 316
Q + + F Q TG V + + + ++
Sbjct: 405 QLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVL- 463
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
+ V I SG + +D + I + V SL+ S L S
Sbjct: 464 SYCNDVVCG--DHIIISGHNDQKIRFWDSREPHCTQVIPVQGR-VTSLSLSHDQLHLLSC 520
Query: 377 SNDGYVNVYNIESAALQN--KLD-HKC---WAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
S D + V ++ + ++ + D KC W +V FSPD + DG++ + ++
Sbjct: 521 SRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAV-FSPDRSYALAGSCDGALYIWDVDT 579
Query: 431 FRVLHTFE-EHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
++ + H V V + GS +VSV + + + +++
Sbjct: 580 GKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
Score = 41.9 bits (94), Expect = 0.005
Identities = 25/119 (21%), Positives = 59/119 (49%), Gaps = 3/119 (2%)
Query: 354 IEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQ--NKLDHKCWAV-SVCFSPD 410
++AH V ++ F P + LLA+ D ++++N+ + L+ L+ ++ SV F P
Sbjct: 332 LDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPS 391
Query: 411 GQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
G ++ + + + ++ + E + T H V +F + V+ S+D+++ ++
Sbjct: 392 GYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD 450
Score = 41.1 bits (92), Expect = 0.008
Identities = 25/118 (21%), Positives = 52/118 (44%), Gaps = 2/118 (1%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD--KVLDTRGKFIMSVAWSPDGRYIA 332
S++ + F P+ S +ATGG + ++ ++ ++ + L+ G I SV + P G +
Sbjct: 337 SEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVL 396
Query: 333 SGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA 390
+ + L+ V + + T+ H V + F + S D V +++ A
Sbjct: 397 AATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA 454
Score = 41.1 bits (92), Expect = 0.008
Identities = 30/99 (30%), Positives = 49/99 (49%), Gaps = 9/99 (9%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG-----KFTLSVAYSPDGKYI 63
V +L S D H++S S + + + QV G +T +V +SPD Y
Sbjct: 505 VTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAV-FSPDRSYA 563
Query: 64 ASGALDGIINIFDVAQGKLVHTLEG-HAMSIRSL--CFS 99
+G+ DG + I+DV GKL L+G H ++ ++ C+S
Sbjct: 564 LAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYS 602
>BC026353-1|AAH26353.1| 677|Homo sapiens WD repeat domain 48
protein.
Length = 677
Score = 83.0 bits (196), Expect = 2e-15
Identities = 52/189 (27%), Positives = 94/189 (49%), Gaps = 9/189 (4%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+GK +IS S+ + ++ G L T + ++AY+ D + +AS LD I ++D
Sbjct: 86 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Query: 77 V-------AQGKLVHT--LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
V A V T L G+ SI SL + ++++GS + ++++D
Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK 205
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L GH V ++ + DG + +SGS+D T+R+W L +C T++ H++ VW ++ N
Sbjct: 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFT 265
Query: 188 KIISVSEDK 196
+ S D+
Sbjct: 266 HVYSGGRDR 274
Score = 58.0 bits (134), Expect = 7e-08
Identities = 44/221 (19%), Positives = 92/221 (41%), Gaps = 24/221 (10%)
Query: 93 IRSLCFSPDSQLLLTGSDDGHMKLYDV-VHAN--LAGTLSGHASWVLSVAFSPDGKRFVS 149
+ +L P L T D ++++ V H ++ H WV + +GK +S
Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92
Query: 150 GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLD 209
S+D TV+VW+ C T + H D V K ++ ++D K+ + + GLD
Sbjct: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYV----------KALAYAKD----KELVASAGLD 138
Query: 210 NLVKVWSYE-------NNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+ +W +N +L G++ + S+A++ G I
Sbjct: 139 RQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPR 198
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI 303
K+ +++ + ++ ++ + DG+Q +G G + ++ +
Sbjct: 199 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239
Score = 50.4 bits (115), Expect = 1e-05
Identities = 42/196 (21%), Positives = 87/196 (44%), Gaps = 10/196 (5%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGS 339
IV +G + + V V+ G L T ++ ++A++ D +AS
Sbjct: 81 IVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQ 140
Query: 340 VYLFDVSQGKML---------HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA 390
++L+DV+ L ++ + ++ SLA + ++ S S + + V++ +
Sbjct: 141 IFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTC 200
Query: 391 ALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQF 449
A KL H ++ + DG + + ++DG+IR+ L + R + T+ H V +Q
Sbjct: 201 AKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQV 260
Query: 450 NADGSKLVSVSKDKSI 465
N + + S +D+ I
Sbjct: 261 NDAFTHVYSGGRDRKI 276
Score = 46.8 bits (106), Expect = 2e-04
Identities = 27/109 (24%), Positives = 51/109 (46%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
S+A + G I SG+ + ++ ++D + L+GH ++++L + D L+GS DG
Sbjct: 173 SLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDG 232
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
++L+ + T H V ++ + SG DR + DL
Sbjct: 233 TIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281
Score = 39.9 bits (89), Expect = 0.019
Identities = 32/152 (21%), Positives = 69/152 (45%), Gaps = 10/152 (6%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+G+ + S + +V +++ +G + T+ H V++LA++ +L+ASA D + +++
Sbjct: 86 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Query: 387 IESAALQNKLDHKCWAVSVCFSPDG------QRMATSAADGSIRVVLL----EEFRVLHT 436
+ + ++ S+ + D ++ T GS VL L
Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK 205
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ HT V + N DG++ +S S D +I ++
Sbjct: 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 237
Score = 33.1 bits (72), Expect = 2.2
Identities = 30/131 (22%), Positives = 58/131 (44%), Gaps = 7/131 (5%)
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM---LHT 353
KV V +I V+K + G + ++ P + + + ++ V+Q K + +
Sbjct: 14 KVQVSYVIRDEVEKY-NRNG--VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS 70
Query: 354 IEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ 412
+E H V + K L SAS+D V V+N + L HK + ++ ++ D +
Sbjct: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
Query: 413 RMATSAADGSI 423
+A++ D I
Sbjct: 131 LVASAGLDRQI 141
>BC021110-1|AAH21110.1| 421|Homo sapiens WD repeat and SOCS
box-containing 1 protein.
Length = 421
Score = 83.0 bits (196), Expect = 2e-15
Identities = 65/245 (26%), Positives = 110/245 (44%), Gaps = 7/245 (2%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLL-TGSDDGHM 114
+ D +A+G +G I I+DV GKL+ L H +R L F+PD L+L + S D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 115 KLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+++D+ N+ L GH +WV S AFSPD S A + V +W++D + H
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V F+ + + + S D ++ YI +++ + + + ++
Sbjct: 256 HHDVVACDFSPDGALLATASYD---TRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDR 312
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V SV+ S DG +A + ++ S+ + FS DGS +A G
Sbjct: 313 WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLC-CAFSTDGSVLAAGT 370
Query: 294 HTGKV 298
H G V
Sbjct: 371 HDGSV 375
Score = 78.2 bits (184), Expect = 6e-14
Identities = 42/146 (28%), Positives = 75/146 (51%), Gaps = 3/146 (2%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKL-LASASNDGYVNVY 385
D +A+G G + ++DV GK+L + H + VR L F+P L L SAS D + V+
Sbjct: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
Query: 386 NIESAALQNKL--DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
+++ K+ H+ W S FSPD + + A ++ + ++++ ++ E H H
Sbjct: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ DG+ L + S D + I++
Sbjct: 259 VVACDFSPDGALLATASYDTRVYIWD 284
Score = 74.1 bits (174), Expect = 1e-12
Identities = 86/362 (23%), Positives = 147/362 (40%), Gaps = 34/362 (9%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
G +W +VAF+PDG F RTV++ + QC F H + V N+ S ++
Sbjct: 34 GRENW--TVAFAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHGTK--NVT-NSSSLRL 86
Query: 190 ISVSEDKG----PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
+ D G P + I G + + S K +E H D
Sbjct: 87 PRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRF-----RFGQDQL 141
Query: 246 TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK-VTVYGII 304
+A G+ + + + + + F+PDGS + K + V+ +
Sbjct: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
Query: 305 N-GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
+ G + KVL ++ S A+SPD + S +V+L+++ + M+ +E H V +
Sbjct: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
Query: 364 LAFSPKTKLLASASNDGYVNVYNIESAALQNKLDH--------------KCWAVSVCFSP 409
FSP LLA+AS D V +++ + + + H W SV FS
Sbjct: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG +A+ A D +R ++E + + C F+ DGS L + + D S+ +
Sbjct: 322 DGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWA 379
Query: 470 CP 471
P
Sbjct: 380 TP 381
Score = 70.5 bits (165), Expect = 1e-11
Identities = 44/149 (29%), Positives = 72/149 (48%), Gaps = 2/149 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI-ASGALDGII 72
F D + +G N G+I I+ V +GK L + + ++PDG I S + D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 73 NIFDVAQ-GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
++D+ G ++ L GH + S FSPDS +L + + L+++ + L GH
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
V++ FSPDG + S D V +WD
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
Score = 66.1 bits (154), Expect = 3e-10
Identities = 48/166 (28%), Positives = 83/166 (50%), Gaps = 15/166 (9%)
Query: 12 LDFSPDGKHVISGSNAGKIL-IFGV-ESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALD 69
L F+PDG ++ ++ K L ++ + + G +VL + S A+SPD + S
Sbjct: 176 LTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGAS 235
Query: 70 GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA---G 126
+ ++++ + ++ LEGH + + FSPD LL T S D + ++D + ++ G
Sbjct: 236 KAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG 295
Query: 127 TL--------SGHAS--WVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
L +G A+ WV SV+FS DG S + D+ VR W +D
Sbjct: 296 HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341
Score = 33.5 bits (73), Expect = 1.7
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 1 MFETGLTDVW--TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP 58
+F G D W ++ FS DG HV S ++ + + ++ QV L A+S
Sbjct: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFST 361
Query: 59 DGKYIASGALDGII 72
DG +A+G DG +
Sbjct: 362 DGSVLAAGTHDGSV 375
>AK074917-1|BAC11291.1| 421|Homo sapiens protein ( Homo sapiens
cDNA FLJ90436 fis, clone NT2RP3000820, weakly similar to
PUTATIVE SERINE/THREONINE-PROTEIN KINASE PKWA (EC
2.7.1.-). ).
Length = 421
Score = 83.0 bits (196), Expect = 2e-15
Identities = 65/245 (26%), Positives = 110/245 (44%), Gaps = 7/245 (2%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLL-TGSDDGHM 114
+ D +A+G +G I I+DV GKL+ L H +R L F+PD L+L + S D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 115 KLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+++D+ N+ L GH +WV S AFSPD S A + V +W++D + H
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V F+ + + + S D ++ YI +++ + + + ++
Sbjct: 256 HHDVVACDFSPDGALLATASYD---TRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDR 312
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V SV+ S DG +A + ++ S+ + FS DGS +A G
Sbjct: 313 WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLC-CAFSTDGSVLAAGT 370
Query: 294 HTGKV 298
H G V
Sbjct: 371 HDGSV 375
Score = 78.2 bits (184), Expect = 6e-14
Identities = 42/146 (28%), Positives = 75/146 (51%), Gaps = 3/146 (2%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKL-LASASNDGYVNVY 385
D +A+G G + ++DV GK+L + H + VR L F+P L L SAS D + V+
Sbjct: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
Query: 386 NIESAALQNKL--DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
+++ K+ H+ W S FSPD + + A ++ + ++++ ++ E H H
Sbjct: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ DG+ L + S D + I++
Sbjct: 259 VVACDFSPDGALLATASYDTRVYIWD 284
Score = 73.3 bits (172), Expect = 2e-12
Identities = 86/362 (23%), Positives = 146/362 (40%), Gaps = 34/362 (9%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
G +W +VAF+PDG F RTV+ + QC F H + V N+ S ++
Sbjct: 34 GRENW--TVAFAPDGSYFAWSQGHRTVK--PVPWSQCLQNFLLHGTK--NVT-NSSSLRL 86
Query: 190 ISVSEDKG----PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
+ D G P + I G + + S K +E H D
Sbjct: 87 PRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRF-----RFGQDQL 141
Query: 246 TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK-VTVYGII 304
+A G+ + + + + + F+PDGS + K + V+ +
Sbjct: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
Query: 305 N-GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
+ G + KVL ++ S A+SPD + S +V+L+++ + M+ +E H V +
Sbjct: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
Query: 364 LAFSPKTKLLASASNDGYVNVYNIESAALQNKLDH--------------KCWAVSVCFSP 409
FSP LLA+AS D V +++ + + + H W SV FS
Sbjct: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG +A+ A D +R ++E + + C F+ DGS L + + D S+ +
Sbjct: 322 DGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWA 379
Query: 470 CP 471
P
Sbjct: 380 TP 381
Score = 70.5 bits (165), Expect = 1e-11
Identities = 44/149 (29%), Positives = 72/149 (48%), Gaps = 2/149 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI-ASGALDGII 72
F D + +G N G+I I+ V +GK L + + ++PDG I S + D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 73 NIFDVAQ-GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
++D+ G ++ L GH + S FSPDS +L + + L+++ + L GH
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
V++ FSPDG + S D V +WD
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
Score = 66.1 bits (154), Expect = 3e-10
Identities = 48/166 (28%), Positives = 83/166 (50%), Gaps = 15/166 (9%)
Query: 12 LDFSPDGKHVISGSNAGKIL-IFGV-ESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALD 69
L F+PDG ++ ++ K L ++ + + G +VL + S A+SPD + S
Sbjct: 176 LTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGAS 235
Query: 70 GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA---G 126
+ ++++ + ++ LEGH + + FSPD LL T S D + ++D + ++ G
Sbjct: 236 KAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG 295
Query: 127 TL--------SGHAS--WVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
L +G A+ WV SV+FS DG S + D+ VR W +D
Sbjct: 296 HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341
Score = 33.5 bits (73), Expect = 1.7
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 1 MFETGLTDVW--TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP 58
+F G D W ++ FS DG HV S ++ + + ++ QV L A+S
Sbjct: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFST 361
Query: 59 DGKYIASGALDGII 72
DG +A+G DG +
Sbjct: 362 DGSVLAAGTHDGSV 375
>AF468833-1|AAL78650.1| 677|Homo sapiens WD repeat endosomal
protein protein.
Length = 677
Score = 83.0 bits (196), Expect = 2e-15
Identities = 52/189 (27%), Positives = 94/189 (49%), Gaps = 9/189 (4%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+GK +IS S+ + ++ G L T + ++AY+ D + +AS LD I ++D
Sbjct: 86 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Query: 77 V-------AQGKLVHT--LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
V A V T L G+ SI SL + ++++GS + ++++D
Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK 205
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L GH V ++ + DG + +SGS+D T+R+W L +C T++ H++ VW ++ N
Sbjct: 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFT 265
Query: 188 KIISVSEDK 196
+ S D+
Sbjct: 266 HVYSGGRDR 274
Score = 58.0 bits (134), Expect = 7e-08
Identities = 44/221 (19%), Positives = 92/221 (41%), Gaps = 24/221 (10%)
Query: 93 IRSLCFSPDSQLLLTGSDDGHMKLYDV-VHAN--LAGTLSGHASWVLSVAFSPDGKRFVS 149
+ +L P L T D ++++ V H ++ H WV + +GK +S
Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92
Query: 150 GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLD 209
S+D TV+VW+ C T + H D V K ++ ++D K+ + + GLD
Sbjct: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYV----------KALAYAKD----KELVASAGLD 138
Query: 210 NLVKVWSYE-------NNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+ +W +N +L G++ + S+A++ G I
Sbjct: 139 RQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPR 198
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI 303
K+ +++ + ++ ++ + DG+Q +G G + ++ +
Sbjct: 199 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239
Score = 50.4 bits (115), Expect = 1e-05
Identities = 42/196 (21%), Positives = 87/196 (44%), Gaps = 10/196 (5%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGS 339
IV +G + + V V+ G L T ++ ++A++ D +AS
Sbjct: 81 IVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQ 140
Query: 340 VYLFDVSQGKML---------HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA 390
++L+DV+ L ++ + ++ SLA + ++ S S + + V++ +
Sbjct: 141 IFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTC 200
Query: 391 ALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQF 449
A KL H ++ + DG + + ++DG+IR+ L + R + T+ H V +Q
Sbjct: 201 AKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQV 260
Query: 450 NADGSKLVSVSKDKSI 465
N + + S +D+ I
Sbjct: 261 NDAFTHVYSGGRDRKI 276
Score = 46.8 bits (106), Expect = 2e-04
Identities = 27/109 (24%), Positives = 51/109 (46%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
S+A + G I SG+ + ++ ++D + L+GH ++++L + D L+GS DG
Sbjct: 173 SLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDG 232
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
++L+ + T H V ++ + SG DR + DL
Sbjct: 233 TIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281
Score = 39.9 bits (89), Expect = 0.019
Identities = 32/152 (21%), Positives = 69/152 (45%), Gaps = 10/152 (6%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+G+ + S + +V +++ +G + T+ H V++LA++ +L+ASA D + +++
Sbjct: 86 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Query: 387 IESAALQNKLDHKCWAVSVCFSPDG------QRMATSAADGSIRVVLL----EEFRVLHT 436
+ + ++ S+ + D ++ T GS VL L
Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK 205
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ HT V + N DG++ +S S D +I ++
Sbjct: 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 237
Score = 33.1 bits (72), Expect = 2.2
Identities = 30/131 (22%), Positives = 58/131 (44%), Gaps = 7/131 (5%)
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM---LHT 353
KV V +I V+K + G + ++ P + + + ++ V+Q K + +
Sbjct: 14 KVQVSYVIRDEVEKY-NRNG--VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS 70
Query: 354 IEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ 412
+E H V + K L SAS+D V V+N + L HK + ++ ++ D +
Sbjct: 71 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 130
Query: 413 RMATSAADGSI 423
+A++ D I
Sbjct: 131 LVASAGLDRQI 141
>AF112205-1|AAF17193.1| 421|Homo sapiens WSB-1 protein protein.
Length = 421
Score = 83.0 bits (196), Expect = 2e-15
Identities = 65/245 (26%), Positives = 110/245 (44%), Gaps = 7/245 (2%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLL-TGSDDGHM 114
+ D +A+G +G I I+DV GKL+ L H +R L F+PD L+L + S D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 115 KLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+++D+ N+ L GH +WV S AFSPD S A + V +W++D + H
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V F+ + + + S D ++ YI +++ + + + ++
Sbjct: 256 HHDVVACDFSPDGALLATASYD---TRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDR 312
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V SV+ S DG +A + ++ S+ + FS DGS +A G
Sbjct: 313 WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLC-CAFSTDGSVLAAGT 370
Query: 294 HTGKV 298
H G V
Sbjct: 371 HDGSV 375
Score = 78.2 bits (184), Expect = 6e-14
Identities = 42/146 (28%), Positives = 75/146 (51%), Gaps = 3/146 (2%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKL-LASASNDGYVNVY 385
D +A+G G + ++DV GK+L + H + VR L F+P L L SAS D + V+
Sbjct: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
Query: 386 NIESAALQNKL--DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
+++ K+ H+ W S FSPD + + A ++ + ++++ ++ E H H
Sbjct: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ DG+ L + S D + I++
Sbjct: 259 VVACDFSPDGALLATASYDTRVYIWD 284
Score = 74.1 bits (174), Expect = 1e-12
Identities = 86/362 (23%), Positives = 147/362 (40%), Gaps = 34/362 (9%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
G +W +VAF+PDG F RTV++ + QC F H + V N+ S ++
Sbjct: 34 GRENW--TVAFAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHGTK--NVT-NSSSLRL 86
Query: 190 ISVSEDKG----PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
+ D G P + I G + + S K +E H D
Sbjct: 87 PRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRF-----RFGQDQL 141
Query: 246 TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK-VTVYGII 304
+A G+ + + + + + F+PDGS + K + V+ +
Sbjct: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
Query: 305 N-GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
+ G + KVL ++ S A+SPD + S +V+L+++ + M+ +E H V +
Sbjct: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
Query: 364 LAFSPKTKLLASASNDGYVNVYNIESAALQNKLDH--------------KCWAVSVCFSP 409
FSP LLA+AS D V +++ + + + H W SV FS
Sbjct: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG +A+ A D +R ++E + + C F+ DGS L + + D S+ +
Sbjct: 322 DGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWA 379
Query: 470 CP 471
P
Sbjct: 380 TP 381
Score = 70.5 bits (165), Expect = 1e-11
Identities = 44/149 (29%), Positives = 72/149 (48%), Gaps = 2/149 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI-ASGALDGII 72
F D + +G N G+I I+ V +GK L + + ++PDG I S + D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 73 NIFDVAQ-GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
++D+ G ++ L GH + S FSPDS +L + + L+++ + L GH
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
V++ FSPDG + S D V +WD
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
Score = 66.1 bits (154), Expect = 3e-10
Identities = 48/166 (28%), Positives = 83/166 (50%), Gaps = 15/166 (9%)
Query: 12 LDFSPDGKHVISGSNAGKIL-IFGV-ESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALD 69
L F+PDG ++ ++ K L ++ + + G +VL + S A+SPD + S
Sbjct: 176 LTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGAS 235
Query: 70 GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA---G 126
+ ++++ + ++ LEGH + + FSPD LL T S D + ++D + ++ G
Sbjct: 236 KAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG 295
Query: 127 TL--------SGHAS--WVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
L +G A+ WV SV+FS DG S + D+ VR W +D
Sbjct: 296 HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341
Score = 33.5 bits (73), Expect = 1.7
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 1 MFETGLTDVW--TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP 58
+F G D W ++ FS DG HV S ++ + + ++ QV L A+S
Sbjct: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFST 361
Query: 59 DGKYIASGALDGII 72
DG +A+G DG +
Sbjct: 362 DGSVLAAGTHDGSV 375
>AF072880-1|AAD28808.1| 421|Homo sapiens SOCS box-containing WD
protein SWiP-1 protein.
Length = 421
Score = 83.0 bits (196), Expect = 2e-15
Identities = 65/245 (26%), Positives = 110/245 (44%), Gaps = 7/245 (2%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLL-TGSDDGHM 114
+ D +A+G +G I I+DV GKL+ L H +R L F+PD L+L + S D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 115 KLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+++D+ N+ L GH +WV S AFSPD S A + V +W++D + H
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V F+ + + + S D ++ YI +++ + + + ++
Sbjct: 256 HHDVVACDFSPDGALLATASYD---TRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDR 312
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V SV+ S DG +A + ++ S+ + FS DGS +A G
Sbjct: 313 WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLC-CAFSTDGSVLAAGT 370
Query: 294 HTGKV 298
H G V
Sbjct: 371 HDGSV 375
Score = 78.2 bits (184), Expect = 6e-14
Identities = 42/146 (28%), Positives = 75/146 (51%), Gaps = 3/146 (2%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKL-LASASNDGYVNVY 385
D +A+G G + ++DV GK+L + H + VR L F+P L L SAS D + V+
Sbjct: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
Query: 386 NIESAALQNKL--DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
+++ K+ H+ W S FSPD + + A ++ + ++++ ++ E H H
Sbjct: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ DG+ L + S D + I++
Sbjct: 259 VVACDFSPDGALLATASYDTRVYIWD 284
Score = 74.1 bits (174), Expect = 1e-12
Identities = 86/362 (23%), Positives = 147/362 (40%), Gaps = 34/362 (9%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
G +W +VAF+PDG F RTV++ + QC F H + V N+ S ++
Sbjct: 34 GRENW--TVAFAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHGTK--NVT-NSSSLRL 86
Query: 190 ISVSEDKG----PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
+ D G P + I G + + S K +E H D
Sbjct: 87 PRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRF-----RFGQDQL 141
Query: 246 TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK-VTVYGII 304
+A G+ + + + + + F+PDGS + K + V+ +
Sbjct: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
Query: 305 N-GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
+ G + KVL ++ S A+SPD + S +V+L+++ + M+ +E H V +
Sbjct: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
Query: 364 LAFSPKTKLLASASNDGYVNVYNIESAALQNKLDH--------------KCWAVSVCFSP 409
FSP LLA+AS D V +++ + + + H W SV FS
Sbjct: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG +A+ A D +R ++E + + C F+ DGS L + + D S+ +
Sbjct: 322 DGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWA 379
Query: 470 CP 471
P
Sbjct: 380 TP 381
Score = 70.5 bits (165), Expect = 1e-11
Identities = 44/149 (29%), Positives = 72/149 (48%), Gaps = 2/149 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI-ASGALDGII 72
F D + +G N G+I I+ V +GK L + + ++PDG I S + D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 73 NIFDVAQ-GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
++D+ G ++ L GH + S FSPDS +L + + L+++ + L GH
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
V++ FSPDG + S D V +WD
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
Score = 66.1 bits (154), Expect = 3e-10
Identities = 48/166 (28%), Positives = 83/166 (50%), Gaps = 15/166 (9%)
Query: 12 LDFSPDGKHVISGSNAGKIL-IFGV-ESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALD 69
L F+PDG ++ ++ K L ++ + + G +VL + S A+SPD + S
Sbjct: 176 LTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGAS 235
Query: 70 GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA---G 126
+ ++++ + ++ LEGH + + FSPD LL T S D + ++D + ++ G
Sbjct: 236 KAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG 295
Query: 127 TL--------SGHAS--WVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
L +G A+ WV SV+FS DG S + D+ VR W +D
Sbjct: 296 HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341
Score = 33.5 bits (73), Expect = 1.7
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 1 MFETGLTDVW--TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP 58
+F G D W ++ FS DG HV S ++ + + ++ QV L A+S
Sbjct: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFST 361
Query: 59 DGKYIASGALDGII 72
DG +A+G DG +
Sbjct: 362 DGSVLAAGTHDGSV 375
>AF069313-1|AAD20954.2| 421|Homo sapiens WSB1 protein protein.
Length = 421
Score = 83.0 bits (196), Expect = 2e-15
Identities = 65/245 (26%), Positives = 110/245 (44%), Gaps = 7/245 (2%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLL-TGSDDGHM 114
+ D +A+G +G I I+DV GKL+ L H +R L F+PD L+L + S D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 115 KLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+++D+ N+ L GH +WV S AFSPD S A + V +W++D + H
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V F+ + + + S D ++ YI +++ + + + ++
Sbjct: 256 HHDVVACDFSPDGALLATASYD---TRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDR 312
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V SV+ S DG +A + ++ S+ + FS DGS +A G
Sbjct: 313 WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLC-CAFSTDGSVLAAGT 370
Query: 294 HTGKV 298
H G V
Sbjct: 371 HDGSV 375
Score = 78.2 bits (184), Expect = 6e-14
Identities = 42/146 (28%), Positives = 75/146 (51%), Gaps = 3/146 (2%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKL-LASASNDGYVNVY 385
D +A+G G + ++DV GK+L + H + VR L F+P L L SAS D + V+
Sbjct: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
Query: 386 NIESAALQNKL--DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
+++ K+ H+ W S FSPD + + A ++ + ++++ ++ E H H
Sbjct: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ DG+ L + S D + I++
Sbjct: 259 VVACDFSPDGALLATASYDTRVYIWD 284
Score = 74.1 bits (174), Expect = 1e-12
Identities = 86/362 (23%), Positives = 147/362 (40%), Gaps = 34/362 (9%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
G +W +VAF+PDG F RTV++ + QC F H + V N+ S ++
Sbjct: 34 GRENW--TVAFAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHGTK--NVT-NSSSLRL 86
Query: 190 ISVSEDKG----PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGE 245
+ D G P + I G + + S K +E H D
Sbjct: 87 PRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRF-----RFGQDQL 141
Query: 246 TIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGK-VTVYGII 304
+A G+ + + + + + F+PDGS + K + V+ +
Sbjct: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
Query: 305 N-GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRS 363
+ G + KVL ++ S A+SPD + S +V+L+++ + M+ +E H V +
Sbjct: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
Query: 364 LAFSPKTKLLASASNDGYVNVYNIESAALQNKLDH--------------KCWAVSVCFSP 409
FSP LLA+AS D V +++ + + + H W SV FS
Sbjct: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
Query: 410 DGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
DG +A+ A D +R ++E + + C F+ DGS L + + D S+ +
Sbjct: 322 DGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWA 379
Query: 470 CP 471
P
Sbjct: 380 TP 381
Score = 70.5 bits (165), Expect = 1e-11
Identities = 44/149 (29%), Positives = 72/149 (48%), Gaps = 2/149 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI-ASGALDGII 72
F D + +G N G+I I+ V +GK L + + ++PDG I S + D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 73 NIFDVAQ-GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
++D+ G ++ L GH + S FSPDS +L + + L+++ + L GH
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
V++ FSPDG + S D V +WD
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
Score = 66.1 bits (154), Expect = 3e-10
Identities = 48/166 (28%), Positives = 83/166 (50%), Gaps = 15/166 (9%)
Query: 12 LDFSPDGKHVISGSNAGKIL-IFGV-ESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALD 69
L F+PDG ++ ++ K L ++ + + G +VL + S A+SPD + S
Sbjct: 176 LTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGAS 235
Query: 70 GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA---G 126
+ ++++ + ++ LEGH + + FSPD LL T S D + ++D + ++ G
Sbjct: 236 KAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG 295
Query: 127 TL--------SGHAS--WVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
L +G A+ WV SV+FS DG S + D+ VR W +D
Sbjct: 296 HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341
Score = 33.5 bits (73), Expect = 1.7
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 1 MFETGLTDVW--TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP 58
+F G D W ++ FS DG HV S ++ + + ++ QV L A+S
Sbjct: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFST 361
Query: 59 DGKYIASGALDGII 72
DG +A+G DG +
Sbjct: 362 DGSVLAAGTHDGSV 375
>AB040882-1|BAA95973.2| 680|Homo sapiens KIAA1449 protein protein.
Length = 680
Score = 83.0 bits (196), Expect = 2e-15
Identities = 52/189 (27%), Positives = 94/189 (49%), Gaps = 9/189 (4%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+GK +IS S+ + ++ G L T + ++AY+ D + +AS LD I ++D
Sbjct: 89 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 148
Query: 77 V-------AQGKLVHT--LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGT 127
V A V T L G+ SI SL + ++++GS + ++++D
Sbjct: 149 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK 208
Query: 128 LSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESN 187
L GH V ++ + DG + +SGS+D T+R+W L +C T++ H++ VW ++ N
Sbjct: 209 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFT 268
Query: 188 KIISVSEDK 196
+ S D+
Sbjct: 269 HVYSGGRDR 277
Score = 58.0 bits (134), Expect = 7e-08
Identities = 44/221 (19%), Positives = 92/221 (41%), Gaps = 24/221 (10%)
Query: 93 IRSLCFSPDSQLLLTGSDDGHMKLYDV-VHAN--LAGTLSGHASWVLSVAFSPDGKRFVS 149
+ +L P L T D ++++ V H ++ H WV + +GK +S
Sbjct: 36 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 95
Query: 150 GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLD 209
S+D TV+VW+ C T + H D V K ++ ++D K+ + + GLD
Sbjct: 96 ASSDTTVKVWNAHKGFCMSTLRTHKDYV----------KALAYAKD----KELVASAGLD 141
Query: 210 NLVKVWSYE-------NNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX 262
+ +W +N +L G++ + S+A++ G I
Sbjct: 142 RQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPR 201
Query: 263 XGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI 303
K+ +++ + ++ ++ + DG+Q +G G + ++ +
Sbjct: 202 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 242
Score = 50.4 bits (115), Expect = 1e-05
Identities = 42/196 (21%), Positives = 87/196 (44%), Gaps = 10/196 (5%)
Query: 280 IVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGS 339
IV +G + + V V+ G L T ++ ++A++ D +AS
Sbjct: 84 IVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQ 143
Query: 340 VYLFDVSQGKML---------HTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESA 390
++L+DV+ L ++ + ++ SLA + ++ S S + + V++ +
Sbjct: 144 IFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTC 203
Query: 391 ALQNKLD-HKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQF 449
A KL H ++ + DG + + ++DG+IR+ L + R + T+ H V +Q
Sbjct: 204 AKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQV 263
Query: 450 NADGSKLVSVSKDKSI 465
N + + S +D+ I
Sbjct: 264 NDAFTHVYSGGRDRKI 279
Score = 46.8 bits (106), Expect = 2e-04
Identities = 27/109 (24%), Positives = 51/109 (46%)
Query: 53 SVAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
S+A + G I SG+ + ++ ++D + L+GH ++++L + D L+GS DG
Sbjct: 176 SLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDG 235
Query: 113 HMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL 161
++L+ + T H V ++ + SG DR + DL
Sbjct: 236 TIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 284
Score = 39.9 bits (89), Expect = 0.019
Identities = 32/152 (21%), Positives = 69/152 (45%), Gaps = 10/152 (6%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
+G+ + S + +V +++ +G + T+ H V++LA++ +L+ASA D + +++
Sbjct: 89 NGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 148
Query: 387 IESAALQNKLDHKCWAVSVCFSPDG------QRMATSAADGSIRVVLL----EEFRVLHT 436
+ + ++ S+ + D ++ T GS VL L
Sbjct: 149 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK 208
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIY 468
+ HT V + N DG++ +S S D +I ++
Sbjct: 209 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 240
Score = 33.1 bits (72), Expect = 2.2
Identities = 30/131 (22%), Positives = 58/131 (44%), Gaps = 7/131 (5%)
Query: 297 KVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKM---LHT 353
KV V +I V+K + G + ++ P + + + ++ V+Q K + +
Sbjct: 17 KVQVSYVIRDEVEKY-NRNG--VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIAS 73
Query: 354 IEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKCWAVSVCFSPDGQ 412
+E H V + K L SAS+D V V+N + L HK + ++ ++ D +
Sbjct: 74 MEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE 133
Query: 413 RMATSAADGSI 423
+A++ D I
Sbjct: 134 LVASAGLDRQI 144
>AK222501-1|BAD96221.1| 392|Homo sapiens hypothetical protein
FLJ11848 variant protein.
Length = 392
Score = 81.0 bits (191), Expect = 8e-15
Identities = 46/161 (28%), Positives = 74/161 (45%), Gaps = 3/161 (1%)
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
S + DG + I+ + G+L LEGH + S F P ++L+G D +K++ A+
Sbjct: 109 SSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T GH +L A G+ VS S D T R+WD C + + GV A
Sbjct: 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGA 228
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
N I S ++ PS+ + G + + + + E+ KL+ L
Sbjct: 229 ADNSINLGSPEQMPSEREV---GTEAKMLLLAREDKKLQCL 266
Score = 58.8 bits (136), Expect = 4e-08
Identities = 32/107 (29%), Positives = 45/107 (42%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H SI L S L ++ S DG MK++ + L L GH V S F P G +
Sbjct: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVL 150
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
SG D +++W + C TFK H + ++S S D
Sbjct: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRD 197
Score = 49.2 bits (112), Expect = 3e-05
Identities = 35/143 (24%), Positives = 59/143 (41%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
LD S G +S S G + I+ +G+ +VL+ S + P G + SG +D
Sbjct: 98 LDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQ 157
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ I+ V T +GH I + +++ S DG +L+D + G L+
Sbjct: 158 LKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADC 217
Query: 132 ASWVLSVAFSPDGKRFVSGSADR 154
S + VA GS ++
Sbjct: 218 GSSINGVAVGAADNSINLGSPEQ 240
Score = 46.8 bits (106), Expect = 2e-04
Identities = 26/115 (22%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMA 415
H +++ L S + L S+S DG + ++ + L+ L+ + V+ C F P G +
Sbjct: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVL 150
Query: 416 TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ D +++ E+ + TF+ H + G +VS S+D + +++C
Sbjct: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205
Score = 37.9 bits (84), Expect = 0.078
Identities = 24/110 (21%), Positives = 49/110 (44%), Gaps = 1/110 (0%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I + S G S + G++ ++ S G++ +E H V S F P ++ S
Sbjct: 93 KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSG 152
Query: 377 SNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
D + +++ E A+ + HK + G+ + +++ DG+ R+
Sbjct: 153 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARL 202
Score = 34.3 bits (75), Expect = 0.97
Identities = 19/96 (19%), Positives = 41/96 (42%)
Query: 296 GKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
G + ++ NG + +VL+ + S + P G + SG + ++ + T +
Sbjct: 114 GTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFK 173
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAA 391
H + A + + + SAS DG +++ +A
Sbjct: 174 GHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSA 209
>BC106004-1|AAI06005.1| 514|Homo sapiens pleiotropic regulator 1
(PRL1 homolog, Arabidopsis) protein.
Length = 514
Score = 80.2 bits (189), Expect = 1e-14
Identities = 72/321 (22%), Positives = 123/321 (38%), Gaps = 26/321 (8%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
KL + GH +R + P +Q +TGS D +K++D+ L +L+GH S V V
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
S S D+ V+ WDL+ + + H V+G+ D P+
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGL--------------DLHPTI 300
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
D +VT D+ ++W +HTL GH V +V I
Sbjct: 301 DVLVTCSRDSTARIWDVRTK--ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G+ + + +V P A+G + + +G+ + L I
Sbjct: 359 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGS-PDNIKQWKFPDGSFIQNLSGHNAIIN 417
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ--------AVRSLAFSPKTKL 372
++ + DG + SGA+ G+++L+D G + A Q + + AF
Sbjct: 418 TLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESR 476
Query: 373 LASASNDGYVNVYNIESAALQ 393
L +A D + VY + A +
Sbjct: 477 LLTAEADKTIKVYREDDTATE 497
Score = 79.8 bits (188), Expect = 2e-14
Identities = 53/195 (27%), Positives = 88/195 (45%), Gaps = 16/195 (8%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
+A P ++ +G+ D I I+D+A GKL +L GH ++R + S S L + +D
Sbjct: 210 IAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQ 269
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+K +D+ + + GH S V + P V+ S D T R+WD+ + HT H
Sbjct: 270 VKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGH 329
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V V+ A ++ I+TG D +++W K + TL H+
Sbjct: 330 TNAVATVRCQA--------------AEPQIITGSHDTTIRLWDLVAGKTRV--TLTNHKK 373
Query: 234 PVVSVAVSPDGETIA 248
V +V + P T A
Sbjct: 374 SVRAVVLHPRHYTFA 388
Score = 73.3 bits (172), Expect = 2e-12
Identities = 57/233 (24%), Positives = 98/233 (42%), Gaps = 17/233 (7%)
Query: 16 PDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
P + ++GS I I+ + SGK + L V S Y+ S D + +
Sbjct: 214 PGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCW 273
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
D+ K++ GH ++ L P +L+T S D +++DV TLSGH + V
Sbjct: 274 DLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV 333
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+V + ++GS D T+R+WDL + + + T H V V +
Sbjct: 334 ATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLH------------ 381
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
P +G DN +K W + + + L GH + ++ V+ DG ++
Sbjct: 382 --PRHYTFASGSPDN-IKQWKFPDG--SFIQNLSGHNAIINTLTVNSDGVLVS 429
Score = 60.1 bits (139), Expect = 2e-08
Identities = 52/221 (23%), Positives = 98/221 (44%), Gaps = 8/221 (3%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L+ V+ LD P +++ S I+ V + L +V I +
Sbjct: 288 LSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIIT 347
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
G+ D I ++D+ GK TL H S+R++ P +GS D ++K + +
Sbjct: 348 GSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFI 406
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
LSGH + + ++ + DG VSG+ + T+ +WD + + F+ + V ++E
Sbjct: 407 QNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWD---WRTGYNFQRVHAAVQPGSLDSE 462
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLH 226
S I + + D+ S+ ++T D +KV+ ++ E H
Sbjct: 463 SG-IFACAFDQSESR--LLTAEADKTIKVYREDDTATEETH 500
Score = 56.4 bits (130), Expect = 2e-07
Identities = 58/282 (20%), Positives = 107/282 (37%), Gaps = 17/282 (6%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P + VTG D +K+W + KL+L +L GH V V VS +
Sbjct: 214 PGNQWFVTGSADRTIKIWDLASGKLKL--SLTGHISTVRGVIVSTRSPYLFSCGEDKQVK 271
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR S ++ + P + T ++ + L
Sbjct: 272 CWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTN 331
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
+ +V I +G+ ++ L+D+ GK T+ H ++VR++ P+ AS S
Sbjct: 332 AVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGS 391
Query: 378 NDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTF 437
D + + +QN H ++ + DG + S AD + L ++R + F
Sbjct: 392 PDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSGADNG--TMHLWDWRTGYNF 447
Query: 438 EE-HTHI----------VCGVQFNADGSKLVSVSKDKSINIY 468
+ H + + F+ S+L++ DK+I +Y
Sbjct: 448 QRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
Score = 54.8 bits (126), Expect = 6e-07
Identities = 30/153 (19%), Positives = 73/153 (47%), Gaps = 1/153 (0%)
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
++ +A P ++ +G+ ++ ++D++ GK+ ++ H VR + S ++ L S
Sbjct: 206 WVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCG 265
Query: 378 NDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D V +++E + +++ H + P + T + D + R+ + +HT
Sbjct: 266 EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHT 325
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
HT+ V V+ A ++++ S D +I +++
Sbjct: 326 LSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
>BC020786-1|AAH20786.1| 505|Homo sapiens PLRG1 protein protein.
Length = 505
Score = 80.2 bits (189), Expect = 1e-14
Identities = 72/321 (22%), Positives = 123/321 (38%), Gaps = 26/321 (8%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
KL + GH +R + P +Q +TGS D +K++D+ L +L+GH S V V
Sbjct: 186 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 245
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
S S D+ V+ WDL+ + + H V+G+ D P+
Sbjct: 246 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGL--------------DLHPTI 291
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
D +VT D+ ++W +HTL GH V +V I
Sbjct: 292 DVLVTCSRDSTARIWDVRTK--ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 349
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G+ + + +V P A+G + + +G+ + L I
Sbjct: 350 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGS-PDNIKQWKFPDGSFIQNLSGHNAIIN 408
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ--------AVRSLAFSPKTKL 372
++ + DG + SGA+ G+++L+D G + A Q + + AF
Sbjct: 409 TLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESR 467
Query: 373 LASASNDGYVNVYNIESAALQ 393
L +A D + VY + A +
Sbjct: 468 LLTAEADKTIKVYREDDTATE 488
Score = 79.8 bits (188), Expect = 2e-14
Identities = 53/195 (27%), Positives = 88/195 (45%), Gaps = 16/195 (8%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
+A P ++ +G+ D I I+D+A GKL +L GH ++R + S S L + +D
Sbjct: 201 IAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQ 260
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+K +D+ + + GH S V + P V+ S D T R+WD+ + HT H
Sbjct: 261 VKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGH 320
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V V+ A ++ I+TG D +++W K + TL H+
Sbjct: 321 TNAVATVRCQA--------------AEPQIITGSHDTTIRLWDLVAGKTRV--TLTNHKK 364
Query: 234 PVVSVAVSPDGETIA 248
V +V + P T A
Sbjct: 365 SVRAVVLHPRHYTFA 379
Score = 73.3 bits (172), Expect = 2e-12
Identities = 57/233 (24%), Positives = 98/233 (42%), Gaps = 17/233 (7%)
Query: 16 PDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
P + ++GS I I+ + SGK + L V S Y+ S D + +
Sbjct: 205 PGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCW 264
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
D+ K++ GH ++ L P +L+T S D +++DV TLSGH + V
Sbjct: 265 DLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV 324
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+V + ++GS D T+R+WDL + + + T H V V +
Sbjct: 325 ATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLH------------ 372
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
P +G DN +K W + + + L GH + ++ V+ DG ++
Sbjct: 373 --PRHYTFASGSPDN-IKQWKFPDG--SFIQNLSGHNAIINTLTVNSDGVLVS 420
Score = 60.1 bits (139), Expect = 2e-08
Identities = 52/221 (23%), Positives = 98/221 (44%), Gaps = 8/221 (3%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L+ V+ LD P +++ S I+ V + L +V I +
Sbjct: 279 LSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIIT 338
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
G+ D I ++D+ GK TL H S+R++ P +GS D ++K + +
Sbjct: 339 GSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFI 397
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
LSGH + + ++ + DG VSG+ + T+ +WD + + F+ + V ++E
Sbjct: 398 QNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWD---WRTGYNFQRVHAAVQPGSLDSE 453
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLH 226
S I + + D+ S+ ++T D +KV+ ++ E H
Sbjct: 454 SG-IFACAFDQSESR--LLTAEADKTIKVYREDDTATEETH 491
Score = 56.4 bits (130), Expect = 2e-07
Identities = 58/282 (20%), Positives = 107/282 (37%), Gaps = 17/282 (6%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P + VTG D +K+W + KL+L +L GH V V VS +
Sbjct: 205 PGNQWFVTGSADRTIKIWDLASGKLKL--SLTGHISTVRGVIVSTRSPYLFSCGEDKQVK 262
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR S ++ + P + T ++ + L
Sbjct: 263 CWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTN 322
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
+ +V I +G+ ++ L+D+ GK T+ H ++VR++ P+ AS S
Sbjct: 323 AVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGS 382
Query: 378 NDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTF 437
D + + +QN H ++ + DG + S AD + L ++R + F
Sbjct: 383 PDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSGADNG--TMHLWDWRTGYNF 438
Query: 438 EE-HTHI----------VCGVQFNADGSKLVSVSKDKSINIY 468
+ H + + F+ S+L++ DK+I +Y
Sbjct: 439 QRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 480
Score = 54.8 bits (126), Expect = 6e-07
Identities = 30/153 (19%), Positives = 73/153 (47%), Gaps = 1/153 (0%)
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
++ +A P ++ +G+ ++ ++D++ GK+ ++ H VR + S ++ L S
Sbjct: 197 WVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCG 256
Query: 378 NDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D V +++E + +++ H + P + T + D + R+ + +HT
Sbjct: 257 EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHT 316
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
HT+ V V+ A ++++ S D +I +++
Sbjct: 317 LSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 349
>AF044333-1|AAD09407.1| 514|Homo sapiens pleiotropic regulator 1
protein.
Length = 514
Score = 80.2 bits (189), Expect = 1e-14
Identities = 72/321 (22%), Positives = 123/321 (38%), Gaps = 26/321 (8%)
Query: 81 KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAF 140
KL + GH +R + P +Q +TGS D +K++D+ L +L+GH S V V
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
Query: 141 SPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSK 200
S S D+ V+ WDL+ + + H V+G+ D P+
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGL--------------DLHPTI 300
Query: 201 DYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXX 260
D +VT D+ ++W +HTL GH V +V I
Sbjct: 301 DVLVTCSRDSTARIWDVRTK--ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
Query: 261 XXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIM 320
G+ + + +V P A+G + + +G+ + L I
Sbjct: 359 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGS-PDNIKQWKFPDGSFIQNLSGHNAIIN 417
Query: 321 SVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQ--------AVRSLAFSPKTKL 372
++ + DG + SGA+ G+++L+D G + A Q + + AF
Sbjct: 418 TLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESR 476
Query: 373 LASASNDGYVNVYNIESAALQ 393
L +A D + VY + A +
Sbjct: 477 LLTAEADKTIKVYREDDTATE 497
Score = 79.8 bits (188), Expect = 2e-14
Identities = 53/195 (27%), Positives = 88/195 (45%), Gaps = 16/195 (8%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
+A P ++ +G+ D I I+D+A GKL +L GH ++R + S S L + +D
Sbjct: 210 IAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQ 269
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+K +D+ + + GH S V + P V+ S D T R+WD+ + HT H
Sbjct: 270 VKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGH 329
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V V+ A ++ I+TG D +++W K + TL H+
Sbjct: 330 TNAVATVRCQA--------------AEPQIITGSHDTTIRLWDLVAGKTRV--TLTNHKK 373
Query: 234 PVVSVAVSPDGETIA 248
V +V + P T A
Sbjct: 374 SVRAVVLHPRHYTFA 388
Score = 73.3 bits (172), Expect = 2e-12
Identities = 57/233 (24%), Positives = 98/233 (42%), Gaps = 17/233 (7%)
Query: 16 PDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIF 75
P + ++GS I I+ + SGK + L V S Y+ S D + +
Sbjct: 214 PGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCW 273
Query: 76 DVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
D+ K++ GH ++ L P +L+T S D +++DV TLSGH + V
Sbjct: 274 DLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV 333
Query: 136 LSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+V + ++GS D T+R+WDL + + + T H V V +
Sbjct: 334 ATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLH------------ 381
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
P +G DN +K W + + + L GH + ++ V+ DG ++
Sbjct: 382 --PRHYTFASGSPDN-IKQWKFPDG--SFIQNLSGHNAIINTLTVNSDGVLVS 429
Score = 60.1 bits (139), Expect = 2e-08
Identities = 52/221 (23%), Positives = 98/221 (44%), Gaps = 8/221 (3%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L+ V+ LD P +++ S I+ V + L +V I +
Sbjct: 288 LSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIIT 347
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA 125
G+ D I ++D+ GK TL H S+R++ P +GS D ++K + +
Sbjct: 348 GSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFI 406
Query: 126 GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAE 185
LSGH + + ++ + DG VSG+ + T+ +WD + + F+ + V ++E
Sbjct: 407 QNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWD---WRTGYNFQRVHAAVQPGSLDSE 462
Query: 186 SNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLH 226
S I + + D+ S+ ++T D +KV+ ++ E H
Sbjct: 463 SG-IFACAFDQSESR--LLTAEADKTIKVYREDDTATEETH 500
Score = 56.4 bits (130), Expect = 2e-07
Identities = 58/282 (20%), Positives = 107/282 (37%), Gaps = 17/282 (6%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P + VTG D +K+W + KL+L +L GH V V VS +
Sbjct: 214 PGNQWFVTGSADRTIKIWDLASGKLKL--SLTGHISTVRGVIVSTRSPYLFSCGEDKQVK 271
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
+ IR S ++ + P + T ++ + L
Sbjct: 272 CWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTN 331
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
+ +V I +G+ ++ L+D+ GK T+ H ++VR++ P+ AS S
Sbjct: 332 AVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGS 391
Query: 378 NDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTF 437
D + + +QN H ++ + DG + S AD + L ++R + F
Sbjct: 392 PDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSGADNG--TMHLWDWRTGYNF 447
Query: 438 EE-HTHI----------VCGVQFNADGSKLVSVSKDKSINIY 468
+ H + + F+ S+L++ DK+I +Y
Sbjct: 448 QRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
Score = 54.8 bits (126), Expect = 6e-07
Identities = 30/153 (19%), Positives = 73/153 (47%), Gaps = 1/153 (0%)
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASAS 377
++ +A P ++ +G+ ++ ++D++ GK+ ++ H VR + S ++ L S
Sbjct: 206 WVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCG 265
Query: 378 NDGYVNVYNIE-SAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHT 436
D V +++E + +++ H + P + T + D + R+ + +HT
Sbjct: 266 EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHT 325
Query: 437 FEEHTHIVCGVQFNADGSKLVSVSKDKSINIYE 469
HT+ V V+ A ++++ S D +I +++
Sbjct: 326 LSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
>AK222576-1|BAD96296.1| 421|Homo sapiens WD SOCS-box protein 1
isoform 1 variant protein.
Length = 421
Score = 79.8 bits (188), Expect = 2e-14
Identities = 64/245 (26%), Positives = 109/245 (44%), Gaps = 7/245 (2%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLL-TGSDDGHM 114
+ D +A+G +G I I+DV GKL+ L H +R L F+PD L+L + S D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 115 KLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+++D+ N+ L GH +WV S AFSPD S A + V +W++D +
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGR 255
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V F+ + + + S D ++ YI +++ + + + ++
Sbjct: 256 HHDVVACDFSPDGALLATASYD---TRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDR 312
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V SV+ S DG +A + ++ S+ + FS DGS +A G
Sbjct: 313 WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLC-CAFSTDGSVLAAGT 370
Query: 294 HTGKV 298
H G V
Sbjct: 371 HDGSV 375
Score = 68.1 bits (159), Expect = 6e-11
Identities = 54/205 (26%), Positives = 96/205 (46%), Gaps = 20/205 (9%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYI-ASGAEGGSV 340
F D +ATG + G++ ++ + G + L + + + ++PDG I S + ++
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 341 YLFDVSQ-GKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHK 399
++D+ G M+ + H V S AFSP + +L S V ++N++ + KL+ +
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGR 255
Query: 400 CWAVSVC-FSPDGQRMATSAADGSIRV------VLLEEFRVLHTFEEHTHIVCG------ 446
V C FSPDG +AT++ D + + +L EF H F T I G
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG--HLFPPPTPIFAGGANDRW 313
Query: 447 ---VQFNADGSKLVSVSKDKSINIY 468
V F+ DG + S++ DK + +
Sbjct: 314 VRSVSFSHDGLHVASLADDKMVRFW 338
Score = 67.3 bits (157), Expect = 1e-10
Identities = 43/149 (28%), Positives = 71/149 (47%), Gaps = 2/149 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI-ASGALDGII 72
F D + +G N G+I I+ V +GK L + + ++PDG I S + D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
Query: 73 NIFDVAQ-GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
++D+ G ++ L GH + S FSPDS +L + + L+++ + L G
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGR 255
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
V++ FSPDG + S D V +WD
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
Score = 62.9 bits (146), Expect = 2e-09
Identities = 47/166 (28%), Positives = 82/166 (49%), Gaps = 15/166 (9%)
Query: 12 LDFSPDGKHVISGSNAGKIL-IFGV-ESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALD 69
L F+PDG ++ ++ K L ++ + + G +VL + S A+SPD + S
Sbjct: 176 LTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGAS 235
Query: 70 GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA---G 126
+ ++++ + ++ LEG + + FSPD LL T S D + ++D + ++ G
Sbjct: 236 KAVFLWNMDKYTMIRKLEGRHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG 295
Query: 127 TL--------SGHAS--WVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
L +G A+ WV SV+FS DG S + D+ VR W +D
Sbjct: 296 HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341
Score = 62.5 bits (145), Expect = 3e-09
Identities = 68/306 (22%), Positives = 124/306 (40%), Gaps = 41/306 (13%)
Query: 175 DQVWGVKFNA----ESNKIISVSEDK---GPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
D VW + F + + ++ +++ + G + + TG + +K+W KL L
Sbjct: 108 DIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL--N 165
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX--XXXXGQKIREIQTDSSDMWKIVFSPD 285
L H V + +PDG I G ++ ++ + ++ FSPD
Sbjct: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 225
Query: 286 GSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV 345
S + + G + V ++ + T+ + L+ R +++ +SPDG +A+ + VY++D
Sbjct: 226 SSMLCSVGASKAVFLWNMDKYTMIRKLEGRHHDVVACDFSPDGALLATASYDTRVYIWDP 285
Query: 346 SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSV 405
G +L H F P T + A +ND W SV
Sbjct: 286 HNGDILMEF-GH-------LFPPPTPIFAGGANDR--------------------WVRSV 317
Query: 406 CFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSI 465
FS DG +A+ A D +R ++E + + C F+ DGS L + + D S+
Sbjct: 318 SFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSV 375
Query: 466 NIYECP 471
+ P
Sbjct: 376 YFWATP 381
Score = 33.5 bits (73), Expect = 1.7
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 1 MFETGLTDVW--TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP 58
+F G D W ++ FS DG HV S ++ + + ++ QV L A+S
Sbjct: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFST 361
Query: 59 DGKYIASGALDGII 72
DG +A+G DG +
Sbjct: 362 DGSVLAAGTHDGSV 375
>U63810-1|AAC24948.1| 339|Homo sapiens WD40 protein Ciao 1 protein.
Length = 339
Score = 79.4 bits (187), Expect = 3e-14
Identities = 57/197 (28%), Positives = 94/197 (47%), Gaps = 10/197 (5%)
Query: 10 WTLDFSPDGKHVISGSNAGKILIFGVESGKQ--EQVLDTRGKFTL-SVAYSPDGKYIASG 66
W L ++P G + S +I I+G E + VL + T+ VA+SP G Y+AS
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 67 ALDGIINIFDVAQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN- 123
+ D I+ Q + V TLEGH ++S+ ++P LL T S D + +++V +
Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139
Query: 124 --LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEHNDQVWG 179
L+ H V V + P + S S D TV+++ + D C T + H VW
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 180 VKFNAESNKIISVSEDK 196
+ F+ ++ S S+D+
Sbjct: 200 LAFDPSGQRLASCSDDR 216
Score = 74.5 bits (175), Expect = 7e-13
Identities = 53/210 (25%), Positives = 105/210 (50%), Gaps = 11/210 (5%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRG--KFIMSVAWSPDGRYI 331
S W + ++P G+ +A+ G ++ ++G + + K + + G + + VAWSP G Y+
Sbjct: 17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYL 76
Query: 332 ASGAEGGSVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-- 387
AS + + ++ +Q + + T+E H V+S+A++P LLA+ S D V V+ +
Sbjct: 77 ASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDE 136
Query: 388 --ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE--FRVLHTFEEHTHI 443
E + H V + P + +A+++ D ++++ EE + T E H
Sbjct: 137 EDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHEST 196
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYECPIP 473
V + F+ G +L S S D+++ I+ +P
Sbjct: 197 VWSLAFDPSGQRLASCSDDRTVRIWRQYLP 226
Score = 70.9 bits (166), Expect = 9e-12
Identities = 86/339 (25%), Positives = 137/339 (40%), Gaps = 42/339 (12%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTL---EGHAMSIRSLCFSPDSQLLLTGSD 110
+A++P G +AS D I I+ + EGH ++R + +SP L + S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 111 DGHMKLYDVVHANL--AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL---DSMQ 165
D ++ + TL GH + V SVA++P G + S D++V VW++ D +
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Query: 166 CQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
C H V V ++ PS++ + + D+ VK++ E +
Sbjct: 142 CVSVLNSHTQDVKHVVWH--------------PSQELLASASYDDTVKLYREEEDDWVCC 187
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSD-MWKIVFSP 284
TLEGHE V S+A P G+ +A + + SD WK + +
Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICT- 246
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
+G H+ T+Y I + L T A D +
Sbjct: 247 -----LSGFHSR--TIYDIAWCQLTGALAT--------ACGDDAIRVFQEDPNSDPQQPT 291
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTK-LLASASNDGYV 382
S LH +AH+Q V +A++PK LLAS S+DG V
Sbjct: 292 FSLTAHLH--QAHSQDVNCVAWNPKEPGLLASCSDDGEV 328
Score = 70.9 bits (166), Expect = 9e-12
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIASGALDGI 71
+SP G ++ S S I+ E V G SVA++P G +A+ + D
Sbjct: 69 WSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 72 INIFDVAQG---KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN--LAG 126
+ +++V + + V L H ++ + + P +LL + S D +KLY +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL GH S V S+AF P G+R S S DRTVR+W
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 52.4 bits (120), Expect = 3e-06
Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 36/271 (13%)
Query: 138 VAFSPDGKRFVSGSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+A++P G S DR +R+W DS C+ E + + V+ A S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWS--------- 70
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXX 255
P +Y+ + D +W + E + TLEGHE V SVA +P G +A
Sbjct: 71 --PCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 256 XXXXXXXXGQK---IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDK 310
+ + + + + D+ +V+ P +A+ + V +Y +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSV-----YLFDVSQG----------KMLHTIE 355
L+ + S+A+ P G+ +AS ++ +V YL QG K + T+
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVY 385
H++ + +A+ T LA+A D + V+
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVF 279
>EF011618-1|ABK41108.1| 339|Homo sapiens CDW8/WDR39 protein.
Length = 339
Score = 79.4 bits (187), Expect = 3e-14
Identities = 57/197 (28%), Positives = 94/197 (47%), Gaps = 10/197 (5%)
Query: 10 WTLDFSPDGKHVISGSNAGKILIFGVESGKQ--EQVLDTRGKFTL-SVAYSPDGKYIASG 66
W L ++P G + S +I I+G E + VL + T+ VA+SP G Y+AS
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 67 ALDGIINIFDVAQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN- 123
+ D I+ Q + V TLEGH ++S+ ++P LL T S D + +++V +
Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139
Query: 124 --LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEHNDQVWG 179
L+ H V V + P + S S D TV+++ + D C T + H VW
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 180 VKFNAESNKIISVSEDK 196
+ F+ ++ S S+D+
Sbjct: 200 LAFDPSGQRLASCSDDR 216
Score = 74.5 bits (175), Expect = 7e-13
Identities = 53/210 (25%), Positives = 105/210 (50%), Gaps = 11/210 (5%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRG--KFIMSVAWSPDGRYI 331
S W + ++P G+ +A+ G ++ ++G + + K + + G + + VAWSP G Y+
Sbjct: 17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYL 76
Query: 332 ASGAEGGSVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-- 387
AS + + ++ +Q + + T+E H V+S+A++P LLA+ S D V V+ +
Sbjct: 77 ASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDE 136
Query: 388 --ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE--FRVLHTFEEHTHI 443
E + H V + P + +A+++ D ++++ EE + T E H
Sbjct: 137 EDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHEST 196
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYECPIP 473
V + F+ G +L S S D+++ I+ +P
Sbjct: 197 VWSLAFDPSGQRLASCSDDRTVRIWRQYLP 226
Score = 70.9 bits (166), Expect = 9e-12
Identities = 86/339 (25%), Positives = 137/339 (40%), Gaps = 42/339 (12%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTL---EGHAMSIRSLCFSPDSQLLLTGSD 110
+A++P G +AS D I I+ + EGH ++R + +SP L + S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 111 DGHMKLYDVVHANL--AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL---DSMQ 165
D ++ + TL GH + V SVA++P G + S D++V VW++ D +
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Query: 166 CQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
C H V V ++ PS++ + + D+ VK++ E +
Sbjct: 142 CVSVLNSHTQDVKHVVWH--------------PSQELLASASYDDTVKLYREEEDDWVCC 187
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSD-MWKIVFSP 284
TLEGHE V S+A P G+ +A + + SD WK + +
Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICT- 246
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
+G H+ T+Y I + L T A D +
Sbjct: 247 -----LSGFHSR--TIYDIAWCQLTGALAT--------ACGDDAIRVFQEDPNSDPQQPT 291
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTK-LLASASNDGYV 382
S LH +AH+Q V +A++PK LLAS S+DG V
Sbjct: 292 FSLTAHLH--QAHSQDVNCVAWNPKEPGLLASCSDDGEV 328
Score = 70.9 bits (166), Expect = 9e-12
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIASGALDGI 71
+SP G ++ S S I+ E V G SVA++P G +A+ + D
Sbjct: 69 WSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 72 INIFDVAQG---KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN--LAG 126
+ +++V + + V L H ++ + + P +LL + S D +KLY +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL GH S V S+AF P G+R S S DRTVR+W
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 52.4 bits (120), Expect = 3e-06
Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 36/271 (13%)
Query: 138 VAFSPDGKRFVSGSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+A++P G S DR +R+W DS C+ E + + V+ A S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWS--------- 70
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXX 255
P +Y+ + D +W + E + TLEGHE V SVA +P G +A
Sbjct: 71 --PCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 256 XXXXXXXXGQK---IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDK 310
+ + + + + D+ +V+ P +A+ + V +Y +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSV-----YLFDVSQG----------KMLHTIE 355
L+ + S+A+ P G+ +AS ++ +V YL QG K + T+
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVY 385
H++ + +A+ T LA+A D + V+
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVF 279
>CR456802-1|CAG33083.1| 339|Homo sapiens CIAO1 protein.
Length = 339
Score = 79.4 bits (187), Expect = 3e-14
Identities = 57/197 (28%), Positives = 94/197 (47%), Gaps = 10/197 (5%)
Query: 10 WTLDFSPDGKHVISGSNAGKILIFGVESGKQ--EQVLDTRGKFTL-SVAYSPDGKYIASG 66
W L ++P G + S +I I+G E + VL + T+ VA+SP G Y+AS
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 67 ALDGIINIFDVAQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN- 123
+ D I+ Q + V TLEGH ++S+ ++P LL T S D + +++V +
Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139
Query: 124 --LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEHNDQVWG 179
L+ H V V + P + S S D TV+++ + D C T + H VW
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 180 VKFNAESNKIISVSEDK 196
+ F+ ++ S S+D+
Sbjct: 200 LAFDPSGQRLASCSDDR 216
Score = 74.5 bits (175), Expect = 7e-13
Identities = 53/210 (25%), Positives = 105/210 (50%), Gaps = 11/210 (5%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRG--KFIMSVAWSPDGRYI 331
S W + ++P G+ +A+ G ++ ++G + + K + + G + + VAWSP G Y+
Sbjct: 17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYL 76
Query: 332 ASGAEGGSVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-- 387
AS + + ++ +Q + + T+E H V+S+A++P LLA+ S D V V+ +
Sbjct: 77 ASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDE 136
Query: 388 --ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE--FRVLHTFEEHTHI 443
E + H V + P + +A+++ D ++++ EE + T E H
Sbjct: 137 EDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHEST 196
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYECPIP 473
V + F+ G +L S S D+++ I+ +P
Sbjct: 197 VWSLAFDPSGQRLASCSDDRTVRIWRQYLP 226
Score = 70.9 bits (166), Expect = 9e-12
Identities = 86/339 (25%), Positives = 137/339 (40%), Gaps = 42/339 (12%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTL---EGHAMSIRSLCFSPDSQLLLTGSD 110
+A++P G +AS D I I+ + EGH ++R + +SP L + S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 111 DGHMKLYDVVHANL--AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL---DSMQ 165
D ++ + TL GH + V SVA++P G + S D++V VW++ D +
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Query: 166 CQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
C H V V ++ PS++ + + D+ VK++ E +
Sbjct: 142 CVSVLNSHTQDVKHVVWH--------------PSQELLASASYDDTVKLYREEEDDWVCC 187
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSD-MWKIVFSP 284
TLEGHE V S+A P G+ +A + + SD WK + +
Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICT- 246
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
+G H+ T+Y I + L T A D +
Sbjct: 247 -----LSGFHSR--TIYDIAWCQLTGALAT--------ACGDDAIRVFQEDPNSDPQQPT 291
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTK-LLASASNDGYV 382
S LH +AH+Q V +A++PK LLAS S+DG V
Sbjct: 292 FSLTAHLH--QAHSQDVNCVAWNPKEPGLLASCSDDGEV 328
Score = 70.9 bits (166), Expect = 9e-12
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIASGALDGI 71
+SP G ++ S S I+ E V G SVA++P G +A+ + D
Sbjct: 69 WSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 72 INIFDVAQG---KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN--LAG 126
+ +++V + + V L H ++ + + P +LL + S D +KLY +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL GH S V S+AF P G+R S S DRTVR+W
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 52.4 bits (120), Expect = 3e-06
Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 36/271 (13%)
Query: 138 VAFSPDGKRFVSGSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+A++P G S DR +R+W DS C+ E + + V+ A S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWS--------- 70
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXX 255
P +Y+ + D +W + E + TLEGHE V SVA +P G +A
Sbjct: 71 --PCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 256 XXXXXXXXGQK---IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDK 310
+ + + + + D+ +V+ P +A+ + V +Y +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSV-----YLFDVSQG----------KMLHTIE 355
L+ + S+A+ P G+ +AS ++ +V YL QG K + T+
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVY 385
H++ + +A+ T LA+A D + V+
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVF 279
>BC032812-1|AAH32812.1| 339|Homo sapiens cytosolic iron-sulfur
protein assembly 1 homolog (S. cerevisiae) protein.
Length = 339
Score = 79.4 bits (187), Expect = 3e-14
Identities = 57/197 (28%), Positives = 94/197 (47%), Gaps = 10/197 (5%)
Query: 10 WTLDFSPDGKHVISGSNAGKILIFGVESGKQ--EQVLDTRGKFTL-SVAYSPDGKYIASG 66
W L ++P G + S +I I+G E + VL + T+ VA+SP G Y+AS
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 67 ALDGIINIFDVAQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN- 123
+ D I+ Q + V TLEGH ++S+ ++P LL T S D + +++V +
Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139
Query: 124 --LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEHNDQVWG 179
L+ H V V + P + S S D TV+++ + D C T + H VW
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 180 VKFNAESNKIISVSEDK 196
+ F+ ++ S S+D+
Sbjct: 200 LAFDPSGQRLASCSDDR 216
Score = 74.5 bits (175), Expect = 7e-13
Identities = 53/210 (25%), Positives = 105/210 (50%), Gaps = 11/210 (5%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRG--KFIMSVAWSPDGRYI 331
S W + ++P G+ +A+ G ++ ++G + + K + + G + + VAWSP G Y+
Sbjct: 17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYL 76
Query: 332 ASGAEGGSVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-- 387
AS + + ++ +Q + + T+E H V+S+A++P LLA+ S D V V+ +
Sbjct: 77 ASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDE 136
Query: 388 --ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE--FRVLHTFEEHTHI 443
E + H V + P + +A+++ D ++++ EE + T E H
Sbjct: 137 EDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHEST 196
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYECPIP 473
V + F+ G +L S S D+++ I+ +P
Sbjct: 197 VWSLAFDPSGQRLASCSDDRTVRIWRQYLP 226
Score = 70.9 bits (166), Expect = 9e-12
Identities = 86/339 (25%), Positives = 137/339 (40%), Gaps = 42/339 (12%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTL---EGHAMSIRSLCFSPDSQLLLTGSD 110
+A++P G +AS D I I+ + EGH ++R + +SP L + S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 111 DGHMKLYDVVHANL--AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL---DSMQ 165
D ++ + TL GH + V SVA++P G + S D++V VW++ D +
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Query: 166 CQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
C H V V ++ PS++ + + D+ VK++ E +
Sbjct: 142 CVSVLNSHTQDVKHVVWH--------------PSQELLASASYDDTVKLYREEEDDWVCC 187
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSD-MWKIVFSP 284
TLEGHE V S+A P G+ +A + + SD WK + +
Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICT- 246
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
+G H+ T+Y I + L T A D +
Sbjct: 247 -----LSGFHSR--TIYDIAWCQLTGALAT--------ACGDDAIRVFQEDPNSDPQQPT 291
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTK-LLASASNDGYV 382
S LH +AH+Q V +A++PK LLAS S+DG V
Sbjct: 292 FSLTAHLH--QAHSQDVNCVAWNPKEPGLLASCSDDGEV 328
Score = 70.9 bits (166), Expect = 9e-12
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIASGALDGI 71
+SP G ++ S S I+ E V G SVA++P G +A+ + D
Sbjct: 69 WSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 72 INIFDVAQG---KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN--LAG 126
+ +++V + + V L H ++ + + P +LL + S D +KLY +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL GH S V S+AF P G+R S S DRTVR+W
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 52.4 bits (120), Expect = 3e-06
Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 36/271 (13%)
Query: 138 VAFSPDGKRFVSGSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+A++P G S DR +R+W DS C+ E + + V+ A S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWS--------- 70
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXX 255
P +Y+ + D +W + E + TLEGHE V SVA +P G +A
Sbjct: 71 --PCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 256 XXXXXXXXGQK---IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDK 310
+ + + + + D+ +V+ P +A+ + V +Y +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSV-----YLFDVSQG----------KMLHTIE 355
L+ + S+A+ P G+ +AS ++ +V YL QG K + T+
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVY 385
H++ + +A+ T LA+A D + V+
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVF 279
>BC001395-1|AAH01395.1| 339|Homo sapiens cytosolic iron-sulfur
protein assembly 1 homolog (S. cerevisiae) protein.
Length = 339
Score = 79.4 bits (187), Expect = 3e-14
Identities = 57/197 (28%), Positives = 94/197 (47%), Gaps = 10/197 (5%)
Query: 10 WTLDFSPDGKHVISGSNAGKILIFGVESGKQ--EQVLDTRGKFTL-SVAYSPDGKYIASG 66
W L ++P G + S +I I+G E + VL + T+ VA+SP G Y+AS
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 67 ALDGIINIFDVAQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN- 123
+ D I+ Q + V TLEGH ++S+ ++P LL T S D + +++V +
Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139
Query: 124 --LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEHNDQVWG 179
L+ H V V + P + S S D TV+++ + D C T + H VW
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 180 VKFNAESNKIISVSEDK 196
+ F+ ++ S S+D+
Sbjct: 200 LAFDPSGQRLASCSDDR 216
Score = 74.5 bits (175), Expect = 7e-13
Identities = 53/210 (25%), Positives = 105/210 (50%), Gaps = 11/210 (5%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRG--KFIMSVAWSPDGRYI 331
S W + ++P G+ +A+ G ++ ++G + + K + + G + + VAWSP G Y+
Sbjct: 17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYL 76
Query: 332 ASGAEGGSVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-- 387
AS + + ++ +Q + + T+E H V+S+A++P LLA+ S D V V+ +
Sbjct: 77 ASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDE 136
Query: 388 --ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE--FRVLHTFEEHTHI 443
E + H V + P + +A+++ D ++++ EE + T E H
Sbjct: 137 EDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHEST 196
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYECPIP 473
V + F+ G +L S S D+++ I+ +P
Sbjct: 197 VWSLAFDPSGQRLASCSDDRTVRIWRQYLP 226
Score = 70.9 bits (166), Expect = 9e-12
Identities = 86/339 (25%), Positives = 137/339 (40%), Gaps = 42/339 (12%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTL---EGHAMSIRSLCFSPDSQLLLTGSD 110
+A++P G +AS D I I+ + EGH ++R + +SP L + S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 111 DGHMKLYDVVHANL--AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL---DSMQ 165
D ++ + TL GH + V SVA++P G + S D++V VW++ D +
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Query: 166 CQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
C H V V ++ PS++ + + D+ VK++ E +
Sbjct: 142 CVSVLNSHTQDVKHVVWH--------------PSQELLASASYDDTVKLYREEEDDWVCC 187
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSD-MWKIVFSP 284
TLEGHE V S+A P G+ +A + + SD WK + +
Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICT- 246
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
+G H+ T+Y I + L T A D +
Sbjct: 247 -----LSGFHSR--TIYDIAWCQLTGALAT--------ACGDDAIRVFQEDPNSDPQQPT 291
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTK-LLASASNDGYV 382
S LH +AH+Q V +A++PK LLAS S+DG V
Sbjct: 292 FSLTAHLH--QAHSQDVNCVAWNPKEPGLLASCSDDGEV 328
Score = 70.9 bits (166), Expect = 9e-12
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIASGALDGI 71
+SP G ++ S S I+ E V G SVA++P G +A+ + D
Sbjct: 69 WSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 72 INIFDVAQG---KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN--LAG 126
+ +++V + + V L H ++ + + P +LL + S D +KLY +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL GH S V S+AF P G+R S S DRTVR+W
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 52.4 bits (120), Expect = 3e-06
Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 36/271 (13%)
Query: 138 VAFSPDGKRFVSGSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+A++P G S DR +R+W DS C+ E + + V+ A S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWS--------- 70
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXX 255
P +Y+ + D +W + E + TLEGHE V SVA +P G +A
Sbjct: 71 --PCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 256 XXXXXXXXGQK---IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDK 310
+ + + + + D+ +V+ P +A+ + V +Y +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSV-----YLFDVSQG----------KMLHTIE 355
L+ + S+A+ P G+ +AS ++ +V YL QG K + T+
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVY 385
H++ + +A+ T LA+A D + V+
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVF 279
>AK223257-1|BAD96977.1| 339|Homo sapiens WD40 protein Ciao1 variant
protein.
Length = 339
Score = 79.4 bits (187), Expect = 3e-14
Identities = 57/197 (28%), Positives = 94/197 (47%), Gaps = 10/197 (5%)
Query: 10 WTLDFSPDGKHVISGSNAGKILIFGVESGKQ--EQVLDTRGKFTL-SVAYSPDGKYIASG 66
W L ++P G + S +I I+G E + VL + T+ VA+SP G Y+AS
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 67 ALDGIINIFDVAQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN- 123
+ D I+ Q + V TLEGH ++S+ ++P LL T S D + +++V +
Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139
Query: 124 --LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEHNDQVWG 179
L+ H V V + P + S S D TV+++ + D C T + H VW
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 180 VKFNAESNKIISVSEDK 196
+ F+ ++ S S+D+
Sbjct: 200 LAFDPSGQRLASCSDDR 216
Score = 74.5 bits (175), Expect = 7e-13
Identities = 53/210 (25%), Positives = 105/210 (50%), Gaps = 11/210 (5%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRG--KFIMSVAWSPDGRYI 331
S W + ++P G+ +A+ G ++ ++G + + K + + G + + VAWSP G Y+
Sbjct: 17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYL 76
Query: 332 ASGAEGGSVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-- 387
AS + + ++ +Q + + T+E H V+S+A++P LLA+ S D V V+ +
Sbjct: 77 ASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDE 136
Query: 388 --ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE--FRVLHTFEEHTHI 443
E + H V + P + +A+++ D ++++ EE + T E H
Sbjct: 137 EDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHEST 196
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYECPIP 473
V + F+ G +L S S D+++ I+ +P
Sbjct: 197 VWSLAFDPSGQRLASCSDDRTVRIWRQYLP 226
Score = 70.9 bits (166), Expect = 9e-12
Identities = 87/339 (25%), Positives = 136/339 (40%), Gaps = 42/339 (12%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTL---EGHAMSIRSLCFSPDSQLLLTGSD 110
+A++P G +AS D I I+ + EGH ++R + +SP L + S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 111 DGHMKLYDVVHANL--AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL---DSMQ 165
D ++ + TL GH + V SVA++P G + S D++V VW++ D +
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Query: 166 CQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
C H V V ++ PS++ + + D+ VK++ E +
Sbjct: 142 CVSVLNSHTQDVKHVVWH--------------PSQELLASASYDDTVKLYREEEDDWVCC 187
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSD-MWKIVFSP 284
TLEGHE V S+A P G+ +A + + SD WK
Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWK----- 242
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
G +G H+ T+Y I + L T A D +
Sbjct: 243 -GICTLSGFHSR--TIYDIAWCQLTGALAT--------ACGDDAIRVFQEDPNSDPQQPT 291
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTK-LLASASNDGYV 382
S LH +AH+Q V +A++PK LLAS S+DG V
Sbjct: 292 FSLTAHLH--QAHSQDVNCVAWNPKEPGLLASCSDDGEV 328
Score = 70.9 bits (166), Expect = 9e-12
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIASGALDGI 71
+SP G ++ S S I+ E V G SVA++P G +A+ + D
Sbjct: 69 WSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 72 INIFDVAQG---KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN--LAG 126
+ +++V + + V L H ++ + + P +LL + S D +KLY +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL GH S V S+AF P G+R S S DRTVR+W
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
>AC004020-1|AAC23493.1| 339|Homo sapiens Unknown gene product
protein.
Length = 339
Score = 79.4 bits (187), Expect = 3e-14
Identities = 57/197 (28%), Positives = 94/197 (47%), Gaps = 10/197 (5%)
Query: 10 WTLDFSPDGKHVISGSNAGKILIFGVESGKQ--EQVLDTRGKFTL-SVAYSPDGKYIASG 66
W L ++P G + S +I I+G E + VL + T+ VA+SP G Y+AS
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 67 ALDGIINIFDVAQG--KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN- 123
+ D I+ Q + V TLEGH ++S+ ++P LL T S D + +++V +
Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139
Query: 124 --LAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW--DLDSMQCQHTFKEHNDQVWG 179
L+ H V V + P + S S D TV+++ + D C T + H VW
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 180 VKFNAESNKIISVSEDK 196
+ F+ ++ S S+D+
Sbjct: 200 LAFDPSGQRLASCSDDR 216
Score = 74.5 bits (175), Expect = 7e-13
Identities = 53/210 (25%), Positives = 105/210 (50%), Gaps = 11/210 (5%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGT-VDKVLDTRG--KFIMSVAWSPDGRYI 331
S W + ++P G+ +A+ G ++ ++G + + K + + G + + VAWSP G Y+
Sbjct: 17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYL 76
Query: 332 ASGAEGGSVYLFDVSQG--KMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNI-- 387
AS + + ++ +Q + + T+E H V+S+A++P LLA+ S D V V+ +
Sbjct: 77 ASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDE 136
Query: 388 --ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE--FRVLHTFEEHTHI 443
E + H V + P + +A+++ D ++++ EE + T E H
Sbjct: 137 EDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHEST 196
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYECPIP 473
V + F+ G +L S S D+++ I+ +P
Sbjct: 197 VWSLAFDPSGQRLASCSDDRTVRIWRQYLP 226
Score = 70.9 bits (166), Expect = 9e-12
Identities = 86/339 (25%), Positives = 137/339 (40%), Gaps = 42/339 (12%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTL---EGHAMSIRSLCFSPDSQLLLTGSD 110
+A++P G +AS D I I+ + EGH ++R + +SP L + S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 111 DGHMKLYDVVHANL--AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL---DSMQ 165
D ++ + TL GH + V SVA++P G + S D++V VW++ D +
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Query: 166 CQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
C H V V ++ PS++ + + D+ VK++ E +
Sbjct: 142 CVSVLNSHTQDVKHVVWH--------------PSQELLASASYDDTVKLYREEEDDWVCC 187
Query: 226 HTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSD-MWKIVFSP 284
TLEGHE V S+A P G+ +A + + SD WK + +
Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICT- 246
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
+G H+ T+Y I + L T A D +
Sbjct: 247 -----LSGFHSR--TIYDIAWCQLTGALAT--------ACGDDAIRVFQEDPNSDPQQPT 291
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTK-LLASASNDGYV 382
S LH +AH+Q V +A++PK LLAS S+DG V
Sbjct: 292 FSLTAHLH--QAHSQDVNCVAWNPKEPGLLASCSDDGEV 328
Score = 70.9 bits (166), Expect = 9e-12
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 7/153 (4%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRG--KFTLSVAYSPDGKYIASGALDGI 71
+SP G ++ S S I+ E V G SVA++P G +A+ + D
Sbjct: 69 WSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 72 INIFDVAQG---KLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHAN--LAG 126
+ +++V + + V L H ++ + + P +LL + S D +KLY +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 127 TLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
TL GH S V S+AF P G+R S S DRTVR+W
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 52.4 bits (120), Expect = 3e-06
Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 36/271 (13%)
Query: 138 VAFSPDGKRFVSGSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+A++P G S DR +R+W DS C+ E + + V+ A S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWS--------- 70
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXX 255
P +Y+ + D +W + E + TLEGHE V SVA +P G +A
Sbjct: 71 --PCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128
Query: 256 XXXXXXXXGQK---IREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDK 310
+ + + + + D+ +V+ P +A+ + V +Y +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 311 VLDTRGKFIMSVAWSPDGRYIASGAEGGSV-----YLFDVSQG----------KMLHTIE 355
L+ + S+A+ P G+ +AS ++ +V YL QG K + T+
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248
Query: 356 A-HAQAVRSLAFSPKTKLLASASNDGYVNVY 385
H++ + +A+ T LA+A D + V+
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVF 279
>BC028628-1|AAH28628.1| 375|Homo sapiens WDR71 protein protein.
Length = 375
Score = 79.0 bits (186), Expect = 3e-14
Identities = 45/161 (27%), Positives = 73/161 (45%), Gaps = 3/161 (1%)
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
S + DG + I+ + G+L LEGH + F P ++L+G D +K++ A+
Sbjct: 92 SSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 151
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T GH +L A G+ VS S D T R+WD C + + GV A
Sbjct: 152 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGA 211
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
N I S ++ PS+ + G + + + + E+ KL+ L
Sbjct: 212 ADNSINLGSPEQMPSEREV---GTEAKMLLLAREDKKLQCL 249
Score = 56.8 bits (131), Expect = 2e-07
Identities = 31/107 (28%), Positives = 44/107 (41%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H SI L S L ++ S DG MK++ + L L GH V F P G +
Sbjct: 74 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 133
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
SG D +++W + C TFK H + ++S S D
Sbjct: 134 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRD 180
Score = 47.2 bits (107), Expect = 1e-04
Identities = 26/115 (22%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMA 415
H +++ L S + L S+S DG + ++ + L+ L+ + V+ C F P G +
Sbjct: 74 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 133
Query: 416 TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ D +++ E+ + TF+ H + G +VS S+D + +++C
Sbjct: 134 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 188
Score = 47.2 bits (107), Expect = 1e-04
Identities = 34/143 (23%), Positives = 58/143 (40%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
LD S G +S S G + I+ +G+ +VL+ + P G + SG +D
Sbjct: 81 LDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQ 140
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ I+ V T +GH I + +++ S DG +L+D + G L+
Sbjct: 141 LKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADC 200
Query: 132 ASWVLSVAFSPDGKRFVSGSADR 154
S + VA GS ++
Sbjct: 201 GSSINGVAVGAADNSINLGSPEQ 223
Score = 35.9 bits (79), Expect = 0.32
Identities = 23/110 (20%), Positives = 48/110 (43%), Gaps = 1/110 (0%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I + S G S + G++ ++ S G++ +E H V F P ++ S
Sbjct: 76 KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG 135
Query: 377 SNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
D + +++ E A+ + HK + G+ + +++ DG+ R+
Sbjct: 136 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARL 185
Score = 32.3 bits (70), Expect = 3.9
Identities = 18/96 (18%), Positives = 40/96 (41%)
Query: 296 GKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
G + ++ NG + +VL+ + + P G + SG + ++ + T +
Sbjct: 97 GTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFK 156
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAA 391
H + A + + + SAS DG +++ +A
Sbjct: 157 GHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSA 192
>BC006142-1|AAH06142.2| 392|Homo sapiens WD repeat domain 71
protein.
Length = 392
Score = 79.0 bits (186), Expect = 3e-14
Identities = 45/161 (27%), Positives = 73/161 (45%), Gaps = 3/161 (1%)
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
S + DG + I+ + G+L LEGH + F P ++L+G D +K++ A+
Sbjct: 109 SSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T GH +L A G+ VS S D T R+WD C + + GV A
Sbjct: 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGA 228
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
N I S ++ PS+ + G + + + + E+ KL+ L
Sbjct: 229 ADNSINLGSPEQMPSEREV---GTEAKMLLLAREDKKLQCL 266
Score = 56.8 bits (131), Expect = 2e-07
Identities = 31/107 (28%), Positives = 44/107 (41%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H SI L S L ++ S DG MK++ + L L GH V F P G +
Sbjct: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
SG D +++W + C TFK H + ++S S D
Sbjct: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRD 197
Score = 47.2 bits (107), Expect = 1e-04
Identities = 26/115 (22%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMA 415
H +++ L S + L S+S DG + ++ + L+ L+ + V+ C F P G +
Sbjct: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
Query: 416 TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ D +++ E+ + TF+ H + G +VS S+D + +++C
Sbjct: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205
Score = 47.2 bits (107), Expect = 1e-04
Identities = 34/143 (23%), Positives = 58/143 (40%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
LD S G +S S G + I+ +G+ +VL+ + P G + SG +D
Sbjct: 98 LDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQ 157
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ I+ V T +GH I + +++ S DG +L+D + G L+
Sbjct: 158 LKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADC 217
Query: 132 ASWVLSVAFSPDGKRFVSGSADR 154
S + VA GS ++
Sbjct: 218 GSSINGVAVGAADNSINLGSPEQ 240
Score = 35.9 bits (79), Expect = 0.32
Identities = 23/110 (20%), Positives = 48/110 (43%), Gaps = 1/110 (0%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I + S G S + G++ ++ S G++ +E H V F P ++ S
Sbjct: 93 KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG 152
Query: 377 SNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
D + +++ E A+ + HK + G+ + +++ DG+ R+
Sbjct: 153 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARL 202
Score = 32.3 bits (70), Expect = 3.9
Identities = 18/96 (18%), Positives = 40/96 (41%)
Query: 296 GKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
G + ++ NG + +VL+ + + P G + SG + ++ + T +
Sbjct: 114 GTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFK 173
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAA 391
H + A + + + SAS DG +++ +A
Sbjct: 174 GHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSA 209
>AK021910-1|BAB13933.1| 392|Homo sapiens protein ( Homo sapiens
cDNA FLJ11848 fis, clone HEMBA1006708, weakly similar to
HYPOTHETICAL 46.4 KD TRP-ASP REPEATS CONTAINING PROTEIN
IN ).
Length = 392
Score = 79.0 bits (186), Expect = 3e-14
Identities = 45/161 (27%), Positives = 73/161 (45%), Gaps = 3/161 (1%)
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
S + DG + I+ + G+L LEGH + F P ++L+G D +K++ A+
Sbjct: 109 SSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T GH +L A G+ VS S D T R+WD C + + GV A
Sbjct: 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGA 228
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
N I S ++ PS+ + G + + + + E+ KL+ L
Sbjct: 229 ADNSINLGSPEQMPSEREV---GTEAKMLLLAREDKKLQCL 266
Score = 56.8 bits (131), Expect = 2e-07
Identities = 31/107 (28%), Positives = 44/107 (41%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H SI L S L ++ S DG MK++ + L L GH V F P G +
Sbjct: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
SG D +++W + C TFK H + ++S S D
Sbjct: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRD 197
Score = 47.2 bits (107), Expect = 1e-04
Identities = 26/115 (22%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMA 415
H +++ L S + L S+S DG + ++ + L+ L+ + V+ C F P G +
Sbjct: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
Query: 416 TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ D +++ E+ + TF+ H + G +VS S+D + +++C
Sbjct: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205
Score = 47.2 bits (107), Expect = 1e-04
Identities = 34/143 (23%), Positives = 58/143 (40%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
LD S G +S S G + I+ +G+ +VL+ + P G + SG +D
Sbjct: 98 LDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQ 157
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ I+ V T +GH I + +++ S DG +L+D + G L+
Sbjct: 158 LKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADC 217
Query: 132 ASWVLSVAFSPDGKRFVSGSADR 154
S + VA GS ++
Sbjct: 218 GSSINGVAVGAADNSINLGSPEQ 240
Score = 35.9 bits (79), Expect = 0.32
Identities = 23/110 (20%), Positives = 48/110 (43%), Gaps = 1/110 (0%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I + S G S + G++ ++ S G++ +E H V F P ++ S
Sbjct: 93 KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG 152
Query: 377 SNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
D + +++ E A+ + HK + G+ + +++ DG+ R+
Sbjct: 153 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARL 202
Score = 32.3 bits (70), Expect = 3.9
Identities = 18/96 (18%), Positives = 40/96 (41%)
Query: 296 GKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
G + ++ NG + +VL+ + + P G + SG + ++ + T +
Sbjct: 114 GTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFK 173
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAA 391
H + A + + + SAS DG +++ +A
Sbjct: 174 GHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSA 209
>BC111490-1|AAI11491.1| 768|Homo sapiens BRWD3 protein protein.
Length = 768
Score = 78.6 bits (185), Expect = 5e-14
Identities = 91/382 (23%), Positives = 169/382 (44%), Gaps = 42/382 (10%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
VA+ G+ I +G+ D ++ I+ G+L+ TL GH+ I + + ++ L+ GS D
Sbjct: 186 VAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKV 245
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGK---RFV-SGSADRTVRVWDLDSMQCQHT 169
++++ + L GH++ + S+ F P K R++ S AD T+ W Q
Sbjct: 246 VRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW-------QWH 298
Query: 170 FKEHNDQVWGVKFNAESNKIISVSEDKGPSKD-YIVTGGLDNLVKVWSYENNKLELLHTL 228
K + VKF S + +S S +I TG D++++++ + E + L
Sbjct: 299 VKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAEL 358
Query: 229 EGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ 288
E H VV+V +G+++ +I + Q WK +
Sbjct: 359 ESHTDKVVAVQFCNNGDSLRFVSGSRDGTA-------RIWQYQQQE---WKSIV----LD 404
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+AT K+T + +G DK+ T+ K M VAW + + + +++ G
Sbjct: 405 MAT-----KMTGNNLPSGE-DKI--TKLKVTM-VAWDRYDTTVITAVNNFLLKVWNSITG 455
Query: 349 KMLHTIEAHAQAVRSLAFSP-KTKLLASASNDGYVNVYNIE-SAALQNKLD----HKCWA 402
++LHT+ H V L P +++ SA +DG + +++++ ++N + A
Sbjct: 456 QLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGA 515
Query: 403 VSVC-FSPDGQRMATSAADGSI 423
V C FSPDG A + + G +
Sbjct: 516 VFDCKFSPDGNHFACTDSHGHL 537
Score = 64.1 bits (149), Expect = 1e-09
Identities = 75/382 (19%), Positives = 152/382 (39%), Gaps = 43/382 (11%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L+ V+ + F G+ + +GS+ + I+ + G+ L +A + + IA+
Sbjct: 180 LSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAA 239
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ-----LLLTGSD------DGHM 114
G+ D ++ ++ + V L+GH+ SI S+ F P ++ L TG+D H+
Sbjct: 240 GSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHV 299
Query: 115 KLYDVVHANLAGTLSGHASWVLSV-AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
K + T +S +FS G +GS D +R++ L S E
Sbjct: 300 KTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGS--------EV 351
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK-----LELLHTL 228
+++ + + ++K+++V V+G D ++W Y+ + L++ +
Sbjct: 352 PEKI--AELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKM 409
Query: 229 EGHEMP----------VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
G+ +P V VA T+ GQ + + +++
Sbjct: 410 TGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVF 469
Query: 279 KIVFSP-DGSQVATGGHTGKVTVYGIINGTVDK----VLDTRGK-FIMSVAWSPDGRYIA 332
+ P D + + GH G + ++ + GT + +++ +G + +SPDG + A
Sbjct: 470 VLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFA 529
Query: 333 SGAEGGSVYLFDVSQGKMLHTI 354
G + LF K I
Sbjct: 530 CTDSHGHLLLFGFGCSKYYEKI 551
Score = 45.6 bits (103), Expect = 4e-04
Identities = 24/76 (31%), Positives = 38/76 (50%)
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
H + + GH S V VAF G+R +GS D V++W D + T + H+ ++ +
Sbjct: 169 HIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDM 228
Query: 181 KFNAESNKIISVSEDK 196
N E+ I + S DK
Sbjct: 229 AVNYENTLIAAGSCDK 244
Score = 45.6 bits (103), Expect = 4e-04
Identities = 49/212 (23%), Positives = 93/212 (43%), Gaps = 17/212 (8%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S ++ + F G ++ TG V ++ +G + L I +A + + IA+G
Sbjct: 181 SSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG 240
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK----LLASASNDGYVNVY--NIE 388
+ V ++ + + ++ H+ ++ S+ F P TK L S DG + + +++
Sbjct: 241 SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVK 300
Query: 389 SAALQNK----LDHKCWAVSV-C--FSPDGQRMATSAADGSIRVVLL--EEFRVLHTFEE 439
+ +++ + V + C FS G + T + D IR+ L E + E
Sbjct: 301 TMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELES 360
Query: 440 HTHIVCGVQF--NADGSKLVSVSKDKSINIYE 469
HT V VQF N D + VS S+D + I++
Sbjct: 361 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ 392
Score = 31.9 bits (69), Expect = 5.1
Identities = 16/73 (21%), Positives = 35/73 (47%)
Query: 396 LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
L H V F G+R+ T + D +++ ++ R+L T H+ + + N + +
Sbjct: 177 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTL 236
Query: 456 LVSVSKDKSINIY 468
+ + S DK + ++
Sbjct: 237 IAAGSCDKVVRVW 249
>BC021541-1|AAH21541.1| 392|Homo sapiens WD repeat domain 71
protein.
Length = 392
Score = 78.6 bits (185), Expect = 5e-14
Identities = 45/161 (27%), Positives = 73/161 (45%), Gaps = 3/161 (1%)
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
S + DG + I+ + G+L LEGH + F P ++L+G D +K++ A+
Sbjct: 109 SSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T GH +L A G+ VS S D T R+WD C + + GV A
Sbjct: 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSGCLGVLADCGSSINGVAVGA 228
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
N I S ++ PS+ + G + + + + E+ KL+ L
Sbjct: 229 ADNSINLGSPEQMPSEREV---GTEAKMLLLAREDKKLQCL 266
Score = 56.8 bits (131), Expect = 2e-07
Identities = 31/107 (28%), Positives = 44/107 (41%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H SI L S L ++ S DG MK++ + L L GH V F P G +
Sbjct: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
SG D +++W + C TFK H + ++S S D
Sbjct: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRD 197
Score = 48.0 bits (109), Expect = 7e-05
Identities = 34/143 (23%), Positives = 58/143 (40%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
LD S G +S S G + I+ +G+ +VL+ + P G + SG +D
Sbjct: 98 LDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQ 157
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ I+ V T +GH I + +++ S DG +L+D + G L+
Sbjct: 158 LKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSGCLGVLADC 217
Query: 132 ASWVLSVAFSPDGKRFVSGSADR 154
S + VA GS ++
Sbjct: 218 GSSINGVAVGAADNSINLGSPEQ 240
Score = 47.2 bits (107), Expect = 1e-04
Identities = 26/115 (22%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMA 415
H +++ L S + L S+S DG + ++ + L+ L+ + V+ C F P G +
Sbjct: 91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 150
Query: 416 TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ D +++ E+ + TF+ H + G +VS S+D + +++C
Sbjct: 151 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205
Score = 35.9 bits (79), Expect = 0.32
Identities = 23/110 (20%), Positives = 48/110 (43%), Gaps = 1/110 (0%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I + S G S + G++ ++ S G++ +E H V F P ++ S
Sbjct: 93 KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG 152
Query: 377 SNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
D + +++ E A+ + HK + G+ + +++ DG+ R+
Sbjct: 153 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARL 202
Score = 31.9 bits (69), Expect = 5.1
Identities = 17/91 (18%), Positives = 38/91 (41%)
Query: 296 GKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
G + ++ NG + +VL+ + + P G + SG + ++ + T +
Sbjct: 114 GTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFK 173
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
H + A + + + SAS DG +++
Sbjct: 174 GHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
>AY497047-1|AAS45472.1| 1631|Homo sapiens bromodomain and WD repeat
domain containing 3 variant BRWD3-B protein.
Length = 1631
Score = 78.6 bits (185), Expect = 5e-14
Identities = 91/382 (23%), Positives = 169/382 (44%), Gaps = 42/382 (10%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
VA+ G+ I +G+ D ++ I+ G+L+ TL GH+ I + + ++ L+ GS D
Sbjct: 15 VAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKV 74
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGK---RFV-SGSADRTVRVWDLDSMQCQHT 169
++++ + L GH++ + S+ F P K R++ S AD T+ W Q
Sbjct: 75 VRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW-------QWH 127
Query: 170 FKEHNDQVWGVKFNAESNKIISVSEDKGPSKD-YIVTGGLDNLVKVWSYENNKLELLHTL 228
K + VKF S + +S S +I TG D++++++ + E + L
Sbjct: 128 VKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAEL 187
Query: 229 EGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ 288
E H VV+V +G+++ +I + Q WK +
Sbjct: 188 ESHTDKVVAVQFCNNGDSLRFVSGSRDGTA-------RIWQYQQQE---WKSIV----LD 233
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+AT K+T + +G DK+ T+ K M VAW + + + +++ G
Sbjct: 234 MAT-----KMTGNNLPSGE-DKI--TKLKVTM-VAWDRYDTTVITAVNNFLLKVWNSITG 284
Query: 349 KMLHTIEAHAQAVRSLAFSP-KTKLLASASNDGYVNVYNIE-SAALQNKLD----HKCWA 402
++LHT+ H V L P +++ SA +DG + +++++ ++N + A
Sbjct: 285 QLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGA 344
Query: 403 VSVC-FSPDGQRMATSAADGSI 423
V C FSPDG A + + G +
Sbjct: 345 VFDCKFSPDGNHFACTDSHGHL 366
Score = 64.1 bits (149), Expect = 1e-09
Identities = 75/382 (19%), Positives = 152/382 (39%), Gaps = 43/382 (11%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L+ V+ + F G+ + +GS+ + I+ + G+ L +A + + IA+
Sbjct: 9 LSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAA 68
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ-----LLLTGSD------DGHM 114
G+ D ++ ++ + V L+GH+ SI S+ F P ++ L TG+D H+
Sbjct: 69 GSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHV 128
Query: 115 KLYDVVHANLAGTLSGHASWVLSV-AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
K + T +S +FS G +GS D +R++ L S E
Sbjct: 129 KTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGS--------EV 180
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK-----LELLHTL 228
+++ + + ++K+++V V+G D ++W Y+ + L++ +
Sbjct: 181 PEKI--AELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKM 238
Query: 229 EGHEMP----------VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
G+ +P V VA T+ GQ + + +++
Sbjct: 239 TGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVF 298
Query: 279 KIVFSP-DGSQVATGGHTGKVTVYGIINGTVDK----VLDTRGK-FIMSVAWSPDGRYIA 332
+ P D + + GH G + ++ + GT + +++ +G + +SPDG + A
Sbjct: 299 VLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFA 358
Query: 333 SGAEGGSVYLFDVSQGKMLHTI 354
G + LF K I
Sbjct: 359 CTDSHGHLLLFGFGCSKYYEKI 380
Score = 45.6 bits (103), Expect = 4e-04
Identities = 49/212 (23%), Positives = 93/212 (43%), Gaps = 17/212 (8%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S ++ + F G ++ TG V ++ +G + L I +A + + IA+G
Sbjct: 10 SSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG 69
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK----LLASASNDGYVNVY--NIE 388
+ V ++ + + ++ H+ ++ S+ F P TK L S DG + + +++
Sbjct: 70 SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVK 129
Query: 389 SAALQNK----LDHKCWAVSV-C--FSPDGQRMATSAADGSIRVVLL--EEFRVLHTFEE 439
+ +++ + V + C FS G + T + D IR+ L E + E
Sbjct: 130 TMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELES 189
Query: 440 HTHIVCGVQF--NADGSKLVSVSKDKSINIYE 469
HT V VQF N D + VS S+D + I++
Sbjct: 190 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ 221
Score = 31.9 bits (69), Expect = 5.1
Identities = 16/73 (21%), Positives = 35/73 (47%)
Query: 396 LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
L H V F G+R+ T + D +++ ++ R+L T H+ + + N + +
Sbjct: 6 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTL 65
Query: 456 LVSVSKDKSINIY 468
+ + S DK + ++
Sbjct: 66 IAAGSCDKVVRVW 78
>AY497046-1|AAS45471.1| 1802|Homo sapiens bromodomain and WD repeat
domain containing 3 variant BRWD3-A protein.
Length = 1802
Score = 78.6 bits (185), Expect = 5e-14
Identities = 91/382 (23%), Positives = 169/382 (44%), Gaps = 42/382 (10%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
VA+ G+ I +G+ D ++ I+ G+L+ TL GH+ I + + ++ L+ GS D
Sbjct: 186 VAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKV 245
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGK---RFV-SGSADRTVRVWDLDSMQCQHT 169
++++ + L GH++ + S+ F P K R++ S AD T+ W Q
Sbjct: 246 VRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW-------QWH 298
Query: 170 FKEHNDQVWGVKFNAESNKIISVSEDKGPSKD-YIVTGGLDNLVKVWSYENNKLELLHTL 228
K + VKF S + +S S +I TG D++++++ + E + L
Sbjct: 299 VKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAEL 358
Query: 229 EGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ 288
E H VV+V +G+++ +I + Q WK +
Sbjct: 359 ESHTDKVVAVQFCNNGDSLRFVSGSRDGTA-------RIWQYQQQE---WKSIV----LD 404
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+AT K+T + +G DK+ T+ K M VAW + + + +++ G
Sbjct: 405 MAT-----KMTGNNLPSGE-DKI--TKLKVTM-VAWDRYDTTVITAVNNFLLKVWNSITG 455
Query: 349 KMLHTIEAHAQAVRSLAFSP-KTKLLASASNDGYVNVYNIE-SAALQNKLD----HKCWA 402
++LHT+ H V L P +++ SA +DG + +++++ ++N + A
Sbjct: 456 QLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGA 515
Query: 403 VSVC-FSPDGQRMATSAADGSI 423
V C FSPDG A + + G +
Sbjct: 516 VFDCKFSPDGNHFACTDSHGHL 537
Score = 64.1 bits (149), Expect = 1e-09
Identities = 75/382 (19%), Positives = 152/382 (39%), Gaps = 43/382 (11%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L+ V+ + F G+ + +GS+ + I+ + G+ L +A + + IA+
Sbjct: 180 LSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAA 239
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ-----LLLTGSD------DGHM 114
G+ D ++ ++ + V L+GH+ SI S+ F P ++ L TG+D H+
Sbjct: 240 GSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHV 299
Query: 115 KLYDVVHANLAGTLSGHASWVLSV-AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
K + T +S +FS G +GS D +R++ L S E
Sbjct: 300 KTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGS--------EV 351
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK-----LELLHTL 228
+++ + + ++K+++V V+G D ++W Y+ + L++ +
Sbjct: 352 PEKI--AELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKM 409
Query: 229 EGHEMP----------VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
G+ +P V VA T+ GQ + + +++
Sbjct: 410 TGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVF 469
Query: 279 KIVFSP-DGSQVATGGHTGKVTVYGIINGTVDK----VLDTRGK-FIMSVAWSPDGRYIA 332
+ P D + + GH G + ++ + GT + +++ +G + +SPDG + A
Sbjct: 470 VLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFA 529
Query: 333 SGAEGGSVYLFDVSQGKMLHTI 354
G + LF K I
Sbjct: 530 CTDSHGHLLLFGFGCSKYYEKI 551
Score = 45.6 bits (103), Expect = 4e-04
Identities = 24/76 (31%), Positives = 38/76 (50%)
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
H + + GH S V VAF G+R +GS D V++W D + T + H+ ++ +
Sbjct: 169 HIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDM 228
Query: 181 KFNAESNKIISVSEDK 196
N E+ I + S DK
Sbjct: 229 AVNYENTLIAAGSCDK 244
Score = 45.6 bits (103), Expect = 4e-04
Identities = 49/212 (23%), Positives = 93/212 (43%), Gaps = 17/212 (8%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S ++ + F G ++ TG V ++ +G + L I +A + + IA+G
Sbjct: 181 SSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG 240
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK----LLASASNDGYVNVY--NIE 388
+ V ++ + + ++ H+ ++ S+ F P TK L S DG + + +++
Sbjct: 241 SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVK 300
Query: 389 SAALQNK----LDHKCWAVSV-C--FSPDGQRMATSAADGSIRVVLL--EEFRVLHTFEE 439
+ +++ + V + C FS G + T + D IR+ L E + E
Sbjct: 301 TMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELES 360
Query: 440 HTHIVCGVQF--NADGSKLVSVSKDKSINIYE 469
HT V VQF N D + VS S+D + I++
Sbjct: 361 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ 392
Score = 31.9 bits (69), Expect = 5.1
Identities = 16/73 (21%), Positives = 35/73 (47%)
Query: 396 LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
L H V F G+R+ T + D +++ ++ R+L T H+ + + N + +
Sbjct: 177 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTL 236
Query: 456 LVSVSKDKSINIY 468
+ + S DK + ++
Sbjct: 237 IAAGSCDKVVRVW 249
>AL669934-1|CAI95405.1| 1802|Homo sapiens bromodomain and WD repeat
domain containing 3 protein.
Length = 1802
Score = 78.6 bits (185), Expect = 5e-14
Identities = 91/382 (23%), Positives = 169/382 (44%), Gaps = 42/382 (10%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
VA+ G+ I +G+ D ++ I+ G+L+ TL GH+ I + + ++ L+ GS D
Sbjct: 186 VAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKV 245
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGK---RFV-SGSADRTVRVWDLDSMQCQHT 169
++++ + L GH++ + S+ F P K R++ S AD T+ W Q
Sbjct: 246 VRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW-------QWH 298
Query: 170 FKEHNDQVWGVKFNAESNKIISVSEDKGPSKD-YIVTGGLDNLVKVWSYENNKLELLHTL 228
K + VKF S + +S S +I TG D++++++ + E + L
Sbjct: 299 VKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAEL 358
Query: 229 EGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ 288
E H VV+V +G+++ +I + Q WK +
Sbjct: 359 ESHTDKVVAVQFCNNGDSLRFVSGSRDGTA-------RIWQYQQQE---WKSIV----LD 404
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+AT K+T + +G DK+ T+ K M VAW + + + +++ G
Sbjct: 405 MAT-----KMTGNNLPSGE-DKI--TKLKVTM-VAWDRYDTTVITAVNNFLLKVWNSITG 455
Query: 349 KMLHTIEAHAQAVRSLAFSP-KTKLLASASNDGYVNVYNIE-SAALQNKLD----HKCWA 402
++LHT+ H V L P +++ SA +DG + +++++ ++N + A
Sbjct: 456 QLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGA 515
Query: 403 VSVC-FSPDGQRMATSAADGSI 423
V C FSPDG A + + G +
Sbjct: 516 VFDCKFSPDGNHFACTDSHGHL 537
Score = 64.1 bits (149), Expect = 1e-09
Identities = 75/382 (19%), Positives = 152/382 (39%), Gaps = 43/382 (11%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L+ V+ + F G+ + +GS+ + I+ + G+ L +A + + IA+
Sbjct: 180 LSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAA 239
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ-----LLLTGSD------DGHM 114
G+ D ++ ++ + V L+GH+ SI S+ F P ++ L TG+D H+
Sbjct: 240 GSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHV 299
Query: 115 KLYDVVHANLAGTLSGHASWVLSV-AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
K + T +S +FS G +GS D +R++ L S E
Sbjct: 300 KTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGS--------EV 351
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK-----LELLHTL 228
+++ + + ++K+++V V+G D ++W Y+ + L++ +
Sbjct: 352 PEKI--AELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKM 409
Query: 229 EGHEMP----------VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
G+ +P V VA T+ GQ + + +++
Sbjct: 410 TGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVF 469
Query: 279 KIVFSP-DGSQVATGGHTGKVTVYGIINGTVDK----VLDTRGK-FIMSVAWSPDGRYIA 332
+ P D + + GH G + ++ + GT + +++ +G + +SPDG + A
Sbjct: 470 VLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFA 529
Query: 333 SGAEGGSVYLFDVSQGKMLHTI 354
G + LF K I
Sbjct: 530 CTDSHGHLLLFGFGCSKYYEKI 551
Score = 45.6 bits (103), Expect = 4e-04
Identities = 24/76 (31%), Positives = 38/76 (50%)
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
H + + GH S V VAF G+R +GS D V++W D + T + H+ ++ +
Sbjct: 169 HIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDM 228
Query: 181 KFNAESNKIISVSEDK 196
N E+ I + S DK
Sbjct: 229 AVNYENTLIAAGSCDK 244
Score = 45.6 bits (103), Expect = 4e-04
Identities = 49/212 (23%), Positives = 93/212 (43%), Gaps = 17/212 (8%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S ++ + F G ++ TG V ++ +G + L I +A + + IA+G
Sbjct: 181 SSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG 240
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK----LLASASNDGYVNVY--NIE 388
+ V ++ + + ++ H+ ++ S+ F P TK L S DG + + +++
Sbjct: 241 SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVK 300
Query: 389 SAALQNK----LDHKCWAVSV-C--FSPDGQRMATSAADGSIRVVLL--EEFRVLHTFEE 439
+ +++ + V + C FS G + T + D IR+ L E + E
Sbjct: 301 TMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELES 360
Query: 440 HTHIVCGVQF--NADGSKLVSVSKDKSINIYE 469
HT V VQF N D + VS S+D + I++
Sbjct: 361 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ 392
Score = 31.9 bits (69), Expect = 5.1
Identities = 16/73 (21%), Positives = 35/73 (47%)
Query: 396 LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
L H V F G+R+ T + D +++ ++ R+L T H+ + + N + +
Sbjct: 177 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTL 236
Query: 456 LVSVSKDKSINIY 468
+ + S DK + ++
Sbjct: 237 IAAGSCDKVVRVW 249
>AL590031-1|CAI39936.2| 1802|Homo sapiens bromodomain and WD repeat
domain containing 3 protein.
Length = 1802
Score = 78.6 bits (185), Expect = 5e-14
Identities = 91/382 (23%), Positives = 169/382 (44%), Gaps = 42/382 (10%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
VA+ G+ I +G+ D ++ I+ G+L+ TL GH+ I + + ++ L+ GS D
Sbjct: 186 VAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKV 245
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGK---RFV-SGSADRTVRVWDLDSMQCQHT 169
++++ + L GH++ + S+ F P K R++ S AD T+ W Q
Sbjct: 246 VRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW-------QWH 298
Query: 170 FKEHNDQVWGVKFNAESNKIISVSEDKGPSKD-YIVTGGLDNLVKVWSYENNKLELLHTL 228
K + VKF S + +S S +I TG D++++++ + E + L
Sbjct: 299 VKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAEL 358
Query: 229 EGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ 288
E H VV+V +G+++ +I + Q WK +
Sbjct: 359 ESHTDKVVAVQFCNNGDSLRFVSGSRDGTA-------RIWQYQQQE---WKSIV----LD 404
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+AT K+T + +G DK+ T+ K M VAW + + + +++ G
Sbjct: 405 MAT-----KMTGNNLPSGE-DKI--TKLKVTM-VAWDRYDTTVITAVNNFLLKVWNSITG 455
Query: 349 KMLHTIEAHAQAVRSLAFSP-KTKLLASASNDGYVNVYNIE-SAALQNKLD----HKCWA 402
++LHT+ H V L P +++ SA +DG + +++++ ++N + A
Sbjct: 456 QLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGA 515
Query: 403 VSVC-FSPDGQRMATSAADGSI 423
V C FSPDG A + + G +
Sbjct: 516 VFDCKFSPDGNHFACTDSHGHL 537
Score = 64.1 bits (149), Expect = 1e-09
Identities = 75/382 (19%), Positives = 152/382 (39%), Gaps = 43/382 (11%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L+ V+ + F G+ + +GS+ + I+ + G+ L +A + + IA+
Sbjct: 180 LSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAA 239
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ-----LLLTGSD------DGHM 114
G+ D ++ ++ + V L+GH+ SI S+ F P ++ L TG+D H+
Sbjct: 240 GSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHV 299
Query: 115 KLYDVVHANLAGTLSGHASWVLSV-AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
K + T +S +FS G +GS D +R++ L S E
Sbjct: 300 KTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGS--------EV 351
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK-----LELLHTL 228
+++ + + ++K+++V V+G D ++W Y+ + L++ +
Sbjct: 352 PEKI--AELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKM 409
Query: 229 EGHEMP----------VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
G+ +P V VA T+ GQ + + +++
Sbjct: 410 TGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVF 469
Query: 279 KIVFSP-DGSQVATGGHTGKVTVYGIINGTVDK----VLDTRGK-FIMSVAWSPDGRYIA 332
+ P D + + GH G + ++ + GT + +++ +G + +SPDG + A
Sbjct: 470 VLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFA 529
Query: 333 SGAEGGSVYLFDVSQGKMLHTI 354
G + LF K I
Sbjct: 530 CTDSHGHLLLFGFGCSKYYEKI 551
Score = 45.6 bits (103), Expect = 4e-04
Identities = 24/76 (31%), Positives = 38/76 (50%)
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
H + + GH S V VAF G+R +GS D V++W D + T + H+ ++ +
Sbjct: 169 HIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDM 228
Query: 181 KFNAESNKIISVSEDK 196
N E+ I + S DK
Sbjct: 229 AVNYENTLIAAGSCDK 244
Score = 45.6 bits (103), Expect = 4e-04
Identities = 49/212 (23%), Positives = 93/212 (43%), Gaps = 17/212 (8%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S ++ + F G ++ TG V ++ +G + L I +A + + IA+G
Sbjct: 181 SSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG 240
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK----LLASASNDGYVNVY--NIE 388
+ V ++ + + ++ H+ ++ S+ F P TK L S DG + + +++
Sbjct: 241 SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVK 300
Query: 389 SAALQNK----LDHKCWAVSV-C--FSPDGQRMATSAADGSIRVVLL--EEFRVLHTFEE 439
+ +++ + V + C FS G + T + D IR+ L E + E
Sbjct: 301 TMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELES 360
Query: 440 HTHIVCGVQF--NADGSKLVSVSKDKSINIYE 469
HT V VQF N D + VS S+D + I++
Sbjct: 361 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ 392
Score = 31.9 bits (69), Expect = 5.1
Identities = 16/73 (21%), Positives = 35/73 (47%)
Query: 396 LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
L H V F G+R+ T + D +++ ++ R+L T H+ + + N + +
Sbjct: 177 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTL 236
Query: 456 LVSVSKDKSINIY 468
+ + S DK + ++
Sbjct: 237 IAAGSCDKVVRVW 249
>AL512504-2|CAI95143.1| 1802|Homo sapiens bromodomain and WD repeat
domain containing 3 protein.
Length = 1802
Score = 78.6 bits (185), Expect = 5e-14
Identities = 91/382 (23%), Positives = 169/382 (44%), Gaps = 42/382 (10%)
Query: 54 VAYSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGH 113
VA+ G+ I +G+ D ++ I+ G+L+ TL GH+ I + + ++ L+ GS D
Sbjct: 186 VAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKV 245
Query: 114 MKLYDVVHANLAGTLSGHASWVLSVAFSPDGK---RFV-SGSADRTVRVWDLDSMQCQHT 169
++++ + L GH++ + S+ F P K R++ S AD T+ W Q
Sbjct: 246 VRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFW-------QWH 298
Query: 170 FKEHNDQVWGVKFNAESNKIISVSEDKGPSKD-YIVTGGLDNLVKVWSYENNKLELLHTL 228
K + VKF S + +S S +I TG D++++++ + E + L
Sbjct: 299 VKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAEL 358
Query: 229 EGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQ 288
E H VV+V +G+++ +I + Q WK +
Sbjct: 359 ESHTDKVVAVQFCNNGDSLRFVSGSRDGTA-------RIWQYQQQE---WKSIV----LD 404
Query: 289 VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+AT K+T + +G DK+ T+ K M VAW + + + +++ G
Sbjct: 405 MAT-----KMTGNNLPSGE-DKI--TKLKVTM-VAWDRYDTTVITAVNNFLLKVWNSITG 455
Query: 349 KMLHTIEAHAQAVRSLAFSP-KTKLLASASNDGYVNVYNIE-SAALQNKLD----HKCWA 402
++LHT+ H V L P +++ SA +DG + +++++ ++N + A
Sbjct: 456 QLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGA 515
Query: 403 VSVC-FSPDGQRMATSAADGSI 423
V C FSPDG A + + G +
Sbjct: 516 VFDCKFSPDGNHFACTDSHGHL 537
Score = 64.1 bits (149), Expect = 1e-09
Identities = 75/382 (19%), Positives = 152/382 (39%), Gaps = 43/382 (11%)
Query: 6 LTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
L+ V+ + F G+ + +GS+ + I+ + G+ L +A + + IA+
Sbjct: 180 LSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAA 239
Query: 66 GALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQ-----LLLTGSD------DGHM 114
G+ D ++ ++ + V L+GH+ SI S+ F P ++ L TG+D H+
Sbjct: 240 GSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHV 299
Query: 115 KLYDVVHANLAGTLSGHASWVLSV-AFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
K + T +S +FS G +GS D +R++ L S E
Sbjct: 300 KTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGS--------EV 351
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNK-----LELLHTL 228
+++ + + ++K+++V V+G D ++W Y+ + L++ +
Sbjct: 352 PEKI--AELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKM 409
Query: 229 EGHEMP----------VVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMW 278
G+ +P V VA T+ GQ + + +++
Sbjct: 410 TGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVF 469
Query: 279 KIVFSP-DGSQVATGGHTGKVTVYGIINGTVDK----VLDTRGK-FIMSVAWSPDGRYIA 332
+ P D + + GH G + ++ + GT + +++ +G + +SPDG + A
Sbjct: 470 VLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFA 529
Query: 333 SGAEGGSVYLFDVSQGKMLHTI 354
G + LF K I
Sbjct: 530 CTDSHGHLLLFGFGCSKYYEKI 551
Score = 45.6 bits (103), Expect = 4e-04
Identities = 24/76 (31%), Positives = 38/76 (50%)
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGV 180
H + + GH S V VAF G+R +GS D V++W D + T + H+ ++ +
Sbjct: 169 HIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDM 228
Query: 181 KFNAESNKIISVSEDK 196
N E+ I + S DK
Sbjct: 229 AVNYENTLIAAGSCDK 244
Score = 45.6 bits (103), Expect = 4e-04
Identities = 49/212 (23%), Positives = 93/212 (43%), Gaps = 17/212 (8%)
Query: 275 SDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASG 334
S ++ + F G ++ TG V ++ +G + L I +A + + IA+G
Sbjct: 181 SSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG 240
Query: 335 AEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTK----LLASASNDGYVNVY--NIE 388
+ V ++ + + ++ H+ ++ S+ F P TK L S DG + + +++
Sbjct: 241 SCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHVK 300
Query: 389 SAALQNK----LDHKCWAVSV-C--FSPDGQRMATSAADGSIRVVLL--EEFRVLHTFEE 439
+ +++ + V + C FS G + T + D IR+ L E + E
Sbjct: 301 TMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELES 360
Query: 440 HTHIVCGVQF--NADGSKLVSVSKDKSINIYE 469
HT V VQF N D + VS S+D + I++
Sbjct: 361 HTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ 392
Score = 31.9 bits (69), Expect = 5.1
Identities = 16/73 (21%), Positives = 35/73 (47%)
Query: 396 LDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSK 455
L H V F G+R+ T + D +++ ++ R+L T H+ + + N + +
Sbjct: 177 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTL 236
Query: 456 LVSVSKDKSINIY 468
+ + S DK + ++
Sbjct: 237 IAAGSCDKVVRVW 249
>AL031282-15|CAI20051.1| 197|Homo sapiens guanine nucleotide
binding protein (G protein), beta polypeptide 1 protein.
Length = 197
Score = 78.6 bits (185), Expect = 5e-14
Identities = 57/190 (30%), Positives = 92/190 (48%), Gaps = 14/190 (7%)
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
D I + + D ++D+ G+ T GH + SL +PD++L ++G+ D KL+D
Sbjct: 10 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 69
Query: 119 VVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVW 178
V T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ +
Sbjct: 70 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIIC 128
Query: 179 GVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSV 238
G I SVS K S ++ G D VW + K + L GH+ V +
Sbjct: 129 G---------ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCL 175
Query: 239 AVSPDGETIA 248
V+ DG +A
Sbjct: 176 GVTDDGMAVA 185
Score = 78.2 bits (184), Expect = 6e-14
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 16/202 (7%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D +++ S ++ +E+G+Q +S++ +PD + SGA D ++D
Sbjct: 10 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 69
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLS--GHASW 134
V +G T GH I ++CF P+ TGSDD +L+D+ T S
Sbjct: 70 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 129
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
+ SV+FS G+ ++G D VWD H+++V + V++
Sbjct: 130 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRV----------SCLGVTD 179
Query: 195 DKGPSKDYIVTGGLDNLVKVWS 216
D G + + TG D+ +K+W+
Sbjct: 180 D-GMA---VATGSWDSFLKIWN 197
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 38 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 97
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 98 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 157
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 158 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 197
Score = 64.5 bits (150), Expect = 8e-10
Identities = 30/101 (29%), Positives = 50/101 (49%)
Query: 95 SLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADR 154
S C D ++T S D L+D+ T +GH V+S++ +PD + FVSG+ D
Sbjct: 4 SCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 63
Query: 155 TVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
+ ++WD+ C+ TF H + + F N + S+D
Sbjct: 64 SAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDD 104
Score = 64.1 bits (149), Expect = 1e-09
Identities = 39/147 (26%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
D I + + + L+D+ G+ T H V SL+ +P T+L S + D +++
Sbjct: 10 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 69
Query: 387 I-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVC 445
+ E Q H+ ++CF P+G AT + D + R+ L + L T+ H +I+C
Sbjct: 70 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIIC 128
Query: 446 G---VQFNADGSKLVSVSKDKSINIYE 469
G V F+ G L++ D + N+++
Sbjct: 129 GITSVSFSKSGRLLLAGYDDFNCNVWD 155
Score = 51.6 bits (118), Expect = 6e-06
Identities = 34/144 (23%), Positives = 57/144 (39%), Gaps = 3/144 (2%)
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
D +Q+ T ++ I G +MS++ +PD R SGA S L+D
Sbjct: 10 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 69
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHK---CW 401
V +G T H + ++ F P A+ S+D ++++ + H C
Sbjct: 70 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 129
Query: 402 AVSVCFSPDGQRMATSAADGSIRV 425
SV FS G+ + D + V
Sbjct: 130 ITSVSFSKSGRLLLAGYDDFNCNV 153
Score = 42.7 bits (96), Expect = 0.003
Identities = 33/165 (20%), Positives = 70/165 (42%), Gaps = 3/165 (1%)
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
GQ+ + D+ + +PD +G ++ + G + I ++
Sbjct: 31 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 90
Query: 324 WSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+ P+G A+G++ + LFD+ Q M ++ + + S++FS +LL + +D
Sbjct: 91 FFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFN 150
Query: 382 VNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
NV++ A L H + + DG +AT + D +++
Sbjct: 151 CNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 195
>AF106683-1|AAD43036.1| 421|Homo sapiens WSB-1 protein.
Length = 421
Score = 78.6 bits (185), Expect = 5e-14
Identities = 63/245 (25%), Positives = 108/245 (44%), Gaps = 7/245 (2%)
Query: 56 YSPDGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLL-TGSDDGHM 114
+ D +A+G +G I I+DV GKL+ L H +R L +PD L+L + S D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTLAPDGSLILVSASRDKTL 195
Query: 115 KLYDVVH-ANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEH 173
+++D+ N+ L GH +WV S AFSPD A + V +W++D + H
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCPVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 174 NDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEM 233
+ V F+ + + + S D ++ YI +++ + + + ++
Sbjct: 256 HHDVVACDFSPDGALLATASYD---TRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDR 312
Query: 234 PVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGG 293
V SV+ S DG +A + ++ S+ + FS DGS +A G
Sbjct: 313 WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLC-CAFSTDGSVLAAGT 370
Query: 294 HTGKV 298
H G V
Sbjct: 371 HDGSV 375
Score = 74.9 bits (176), Expect = 6e-13
Identities = 41/146 (28%), Positives = 73/146 (50%), Gaps = 3/146 (2%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKL-LASASNDGYVNVY 385
D +A+G G + ++DV GK+L + H + VR L +P L L SAS D + V+
Sbjct: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTLAPDGSLILVSASRDKTLRVW 198
Query: 386 NIESAALQNKL--DHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHI 443
+++ K+ H+ W S FSPD + A ++ + ++++ ++ E H H
Sbjct: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCPVGASKAVFLWNMDKYTMIRKLEGHHHD 258
Query: 444 VCGVQFNADGSKLVSVSKDKSINIYE 469
V F+ DG+ L + S D + I++
Sbjct: 259 VVACDFSPDGALLATASYDTRVYIWD 284
Score = 68.1 bits (159), Expect = 6e-11
Identities = 44/149 (29%), Positives = 70/149 (46%), Gaps = 2/149 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYI-ASGALDGII 72
F D + +G N G+I I+ V +GK L + + +PDG I S + D +
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTLAPDGSLILVSASRDKTL 195
Query: 73 NIFDVAQ-GKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
++D+ G ++ L GH + S FSPDS +L + L+++ + L GH
Sbjct: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCPVGASKAVFLWNMDKYTMIRKLEGH 255
Query: 132 ASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
V++ FSPDG + S D V +WD
Sbjct: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
Score = 61.7 bits (143), Expect = 6e-09
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 15/166 (9%)
Query: 12 LDFSPDGKHVISGSNAGKIL-IFGV-ESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALD 69
L +PDG ++ ++ K L ++ + + G +VL + S A+SPD +
Sbjct: 176 LTLAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCPVGAS 235
Query: 70 GIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLA---G 126
+ ++++ + ++ LEGH + + FSPD LL T S D + ++D + ++ G
Sbjct: 236 KAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFG 295
Query: 127 TL--------SGHAS--WVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
L +G A+ WV SV+FS DG S + D+ VR W +D
Sbjct: 296 HLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID 341
Score = 60.5 bits (140), Expect = 1e-08
Identities = 67/306 (21%), Positives = 123/306 (40%), Gaps = 41/306 (13%)
Query: 175 DQVWGVKFNA----ESNKIISVSEDK---GPSKDYIVTGGLDNLVKVWSYENNKLELLHT 227
D VW + F + + ++ +++ + G + + TG + +K+W KL L
Sbjct: 108 DIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL--N 165
Query: 228 LEGHEMPVVSVAVSPDGETIAXXXXXXXXXXX--XXXXGQKIREIQTDSSDMWKIVFSPD 285
L H V + ++PDG I G ++ ++ + ++ FSPD
Sbjct: 166 LVDHTEVVRDLTLAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 225
Query: 286 GSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV 345
S + G + V ++ + T+ + L+ +++ +SPDG +A+ + VY++D
Sbjct: 226 SSMLCPVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDP 285
Query: 346 SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSV 405
G +L H F P T + A +ND W SV
Sbjct: 286 HNGDILMEF-GH-------LFPPPTPIFAGGANDR--------------------WVRSV 317
Query: 406 CFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSI 465
FS DG +A+ A D +R ++E + + C F+ DGS L + + D S+
Sbjct: 318 SFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSV 375
Query: 466 NIYECP 471
+ P
Sbjct: 376 YFWATP 381
Score = 33.5 bits (73), Expect = 1.7
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 1 MFETGLTDVW--TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSP 58
+F G D W ++ FS DG HV S ++ + + ++ QV L A+S
Sbjct: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFST 361
Query: 59 DGKYIASGALDGII 72
DG +A+G DG +
Sbjct: 362 DGSVLAAGTHDGSV 375
>AF087895-1|AAP97194.1| 375|Homo sapiens G-16 protein.
Length = 375
Score = 78.6 bits (185), Expect = 5e-14
Identities = 45/161 (27%), Positives = 73/161 (45%), Gaps = 3/161 (1%)
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
S + DG + I+ + G+L LEGH + F P ++L+G D +K++ A+
Sbjct: 92 SSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 151
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
T GH +L A G+ VS S D T R+WD C + + GV A
Sbjct: 152 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSGCLGVLADCGSSINGVAVGA 211
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELL 225
N I S ++ PS+ + G + + + + E+ KL+ L
Sbjct: 212 ADNSINLGSPEQMPSEREV---GTEAKMLLLAREDKKLQCL 249
Score = 56.8 bits (131), Expect = 2e-07
Identities = 31/107 (28%), Positives = 44/107 (41%)
Query: 89 HAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFV 148
H SI L S L ++ S DG MK++ + L L GH V F P G +
Sbjct: 74 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 133
Query: 149 SGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
SG D +++W + C TFK H + ++S S D
Sbjct: 134 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRD 180
Score = 48.0 bits (109), Expect = 7e-05
Identities = 34/143 (23%), Positives = 58/143 (40%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI 71
LD S G +S S G + I+ +G+ +VL+ + P G + SG +D
Sbjct: 81 LDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQ 140
Query: 72 INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGH 131
+ I+ V T +GH I + +++ S DG +L+D + G L+
Sbjct: 141 LKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSGCLGVLADC 200
Query: 132 ASWVLSVAFSPDGKRFVSGSADR 154
S + VA GS ++
Sbjct: 201 GSSINGVAVGAADNSINLGSPEQ 223
Score = 47.2 bits (107), Expect = 1e-04
Identities = 26/115 (22%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Query: 357 HAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKCWAVSVC-FSPDGQRMA 415
H +++ L S + L S+S DG + ++ + L+ L+ + V+ C F P G +
Sbjct: 74 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVL 133
Query: 416 TSAADGSIRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ D +++ E+ + TF+ H + G +VS S+D + +++C
Sbjct: 134 SGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 188
Score = 35.9 bits (79), Expect = 0.32
Identities = 23/110 (20%), Positives = 48/110 (43%), Gaps = 1/110 (0%)
Query: 317 KFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASA 376
K I + S G S + G++ ++ S G++ +E H V F P ++ S
Sbjct: 76 KSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSG 135
Query: 377 SNDGYVNVYNIESAA-LQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
D + +++ E A+ + HK + G+ + +++ DG+ R+
Sbjct: 136 GMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARL 185
Score = 31.9 bits (69), Expect = 5.1
Identities = 17/91 (18%), Positives = 38/91 (41%)
Query: 296 GKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIE 355
G + ++ NG + +VL+ + + P G + SG + ++ + T +
Sbjct: 97 GTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFK 156
Query: 356 AHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
H + A + + + SAS DG +++
Sbjct: 157 GHKGGILDTAIVDRGRNVVSASRDGTARLWD 187
>AF070603-1|AAC28655.1| 207|Homo sapiens beta-subunit signal
transducing proteins GS/GI protein.
Length = 207
Score = 78.6 bits (185), Expect = 5e-14
Identities = 57/190 (30%), Positives = 92/190 (48%), Gaps = 14/190 (7%)
Query: 59 DGKYIASGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
D I + + D ++D+ G+ T GH + SL +PD++L ++G+ D KL+D
Sbjct: 20 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 79
Query: 119 VVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVW 178
V T +GH S + ++ F P+G F +GS D T R++DL + Q T+ H++ +
Sbjct: 80 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIIC 138
Query: 179 GVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSV 238
G I SVS K S ++ G D VW + K + L GH+ V +
Sbjct: 139 G---------ITSVSFSK--SGRLLLAGYDDFNCNVW--DALKADRAGVLAGHDNRVSCL 185
Query: 239 AVSPDGETIA 248
V+ DG +A
Sbjct: 186 GVTDDGMAVA 195
Score = 78.2 bits (184), Expect = 6e-14
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 16/202 (7%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
D +++ S ++ +E+G+Q +S++ +PD + SGA D ++D
Sbjct: 20 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 79
Query: 77 VAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLS--GHASW 134
V +G T GH I ++CF P+ TGSDD +L+D+ T S
Sbjct: 80 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 139
Query: 135 VLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSE 194
+ SV+FS G+ ++G D VWD H+++V + V++
Sbjct: 140 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRV----------SCLGVTD 189
Query: 195 DKGPSKDYIVTGGLDNLVKVWS 216
D G + + TG D+ +K+W+
Sbjct: 190 D-GMA---VATGSWDSFLKIWN 207
Score = 77.0 bits (181), Expect = 1e-13
Identities = 45/160 (28%), Positives = 80/160 (50%), Gaps = 3/160 (1%)
Query: 4 TGLT-DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKY 62
TG T DV +L +PD + +SG+ ++ V G Q ++ + P+G
Sbjct: 48 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 107
Query: 63 IASGALDGIINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
A+G+ D +FD+ Q + ++ + I S+ FS +LLL G DD + ++D +
Sbjct: 108 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 167
Query: 121 HANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWD 160
A+ AG L+GH + V + + DG +GS D +++W+
Sbjct: 168 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 207
Score = 66.1 bits (154), Expect = 3e-10
Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 1/110 (0%)
Query: 86 LEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGK 145
L GH + F D+Q++ T S D L+D+ T +GH V+S++ +PD +
Sbjct: 6 LAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 64
Query: 146 RFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
FVSG+ D + ++WD+ C+ TF H + + F N + S+D
Sbjct: 65 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDD 114
Score = 64.1 bits (149), Expect = 1e-09
Identities = 39/147 (26%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 327 DGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYN 386
D I + + + L+D+ G+ T H V SL+ +P T+L S + D +++
Sbjct: 20 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 79
Query: 387 I-ESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVC 445
+ E Q H+ ++CF P+G AT + D + R+ L + L T+ H +I+C
Sbjct: 80 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY-SHDNIIC 138
Query: 446 G---VQFNADGSKLVSVSKDKSINIYE 469
G V F+ G L++ D + N+++
Sbjct: 139 GITSVSFSKSGRLLLAGYDDFNCNVWD 165
Score = 51.6 bits (118), Expect = 6e-06
Identities = 34/144 (23%), Positives = 57/144 (39%), Gaps = 3/144 (2%)
Query: 285 DGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFD 344
D +Q+ T ++ I G +MS++ +PD R SGA S L+D
Sbjct: 20 DDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWD 79
Query: 345 VSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHK---CW 401
V +G T H + ++ F P A+ S+D ++++ + H C
Sbjct: 80 VREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 139
Query: 402 AVSVCFSPDGQRMATSAADGSIRV 425
SV FS G+ + D + V
Sbjct: 140 ITSVSFSKSGRLLLAGYDDFNCNV 163
Score = 42.7 bits (96), Expect = 0.003
Identities = 33/165 (20%), Positives = 70/165 (42%), Gaps = 3/165 (1%)
Query: 264 GQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVA 323
GQ+ + D+ + +PD +G ++ + G + I ++
Sbjct: 41 GQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 100
Query: 324 WSPDGRYIASGAEGGSVYLFDV--SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGY 381
+ P+G A+G++ + LFD+ Q M ++ + + S++FS +LL + +D
Sbjct: 101 FFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFN 160
Query: 382 VNVYNIESAALQNKL-DHKCWAVSVCFSPDGQRMATSAADGSIRV 425
NV++ A L H + + DG +AT + D +++
Sbjct: 161 CNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 205
>AY336089-1|AAR24619.1| 271|Homo sapiens proliferation-inducing
gene 21 protein.
Length = 271
Score = 78.2 bits (184), Expect = 6e-14
Identities = 68/228 (29%), Positives = 106/228 (46%), Gaps = 24/228 (10%)
Query: 130 GHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKI 189
GH VLSVAFS D ++ VSGS D+T+++W+ + C++T ++ + W +
Sbjct: 57 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEW----------V 105
Query: 190 ISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAX 249
V S IV+ G D LVKVW+ N KL+ H GH + +V VSPDG A
Sbjct: 106 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI--GHTGYLNTVTVSPDGSLCAS 163
Query: 250 XXXXXXXXXXXXXXGQKIREIQTDSSDMWK-IVFSPDGSQV--ATGGHTGKVTVYG--II 304
G+ + + D D+ + FSP+ + ATG + G I+
Sbjct: 164 GGKDGQAMLWDLNEGKHLYTL--DGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIV 221
Query: 305 NGTVDKVLDTRGKF----IMSVAWSPDGRYIASGAEGGSVYLFDVSQG 348
+ +V+ T K S+AWS DG+ + +G V ++ V+ G
Sbjct: 222 DELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 269
Score = 67.3 bits (157), Expect = 1e-10
Identities = 52/211 (24%), Positives = 97/211 (45%), Gaps = 10/211 (4%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLD-TRGKFTLSVAYSPDGK--YIA 64
DV ++ FS D + ++SGS I ++ + V D + ++ V +SP+ I
Sbjct: 61 DVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 120
Query: 65 SGALDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANL 124
S D ++ ++++A KL GH + ++ SPD L +G DG L+D+
Sbjct: 121 SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 180
Query: 125 AGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNA 184
TL G + ++ FSP+ + ++ + ++++WDL+ K+ +V A
Sbjct: 181 LYTLDG-GDIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQ---EVISTSSKA 235
Query: 185 ESNKIISVSEDKGPSKDYIVTGGLDNLVKVW 215
E + S++ + G DNLV+VW
Sbjct: 236 EPPQCTSLA--WSADGQTLFAGYTDNLVRVW 264
Score = 60.9 bits (141), Expect = 1e-08
Identities = 56/204 (27%), Positives = 100/204 (49%), Gaps = 16/204 (7%)
Query: 49 KFTLSVAYSPDGKYIASGALDGIINIFDVAQGKLVHTL--EGHAMSIRSLCFSPDSQ--L 104
K LSVA+S D + I SG+ D I +++ G +T+ E H+ + + FSP+S +
Sbjct: 60 KDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPI 118
Query: 105 LLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVWDLDSM 164
+++ D +K++++ + L GH ++ +V SPDG SG D +WDL+
Sbjct: 119 IVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 178
Query: 165 QCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLEL 224
+ +T + D + + F+ + + + GPS I L+ + V + K E+
Sbjct: 179 KHLYTL-DGGDIINALCFSPNRYWLCAAT---GPS---IKIWDLEGKIIV---DELKQEV 228
Query: 225 LHTLEGHEMP-VVSVAVSPDGETI 247
+ T E P S+A S DG+T+
Sbjct: 229 ISTSSKAEPPQCTSLAWSADGQTL 252
Score = 60.5 bits (140), Expect = 1e-08
Identities = 52/210 (24%), Positives = 90/210 (42%), Gaps = 17/210 (8%)
Query: 230 GHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQTDSSDMWK--IVFSPDGS 287
GH V+SVA S D I K +Q +S W + FSP+ S
Sbjct: 57 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYT-VQDESHSEWVSCVRFSPNSS 115
Query: 288 Q--VATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDV 345
+ + G V V+ + N + ++ +V SPDG ASG + G L+D+
Sbjct: 116 NPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 175
Query: 346 SQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKLDHKC----- 400
++GK L+T++ + +L FSP L +A+ + ++++E + ++L +
Sbjct: 176 NEGKHLYTLDG-GDIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSS 233
Query: 401 -----WAVSVCFSPDGQRMATSAADGSIRV 425
S+ +S DGQ + D +RV
Sbjct: 234 KAEPPQCTSLAWSADGQTLFAGYTDNLVRV 263
Score = 59.3 bits (137), Expect = 3e-08
Identities = 41/138 (29%), Positives = 72/138 (52%), Gaps = 6/138 (4%)
Query: 306 GTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTI--EAHAQAVRS 363
GT + K ++SVA+S D R I SG+ ++ L++ + G +T+ E+H++ V
Sbjct: 49 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSC 107
Query: 364 LAFSPKTK--LLASASNDGYVNVYNIESAALQ-NKLDHKCWAVSVCFSPDGQRMATSAAD 420
+ FSP + ++ S D V V+N+ + L+ N + H + +V SPDG A+ D
Sbjct: 108 VRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKD 167
Query: 421 GSIRVVLLEEFRVLHTFE 438
G + L E + L+T +
Sbjct: 168 GQAMLWDLNEGKHLYTLD 185
Score = 49.2 bits (112), Expect = 3e-05
Identities = 41/168 (24%), Positives = 74/168 (44%), Gaps = 20/168 (11%)
Query: 79 QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVH-ANLAGTLSGHASWVLS 137
+G GH + S+ FS D++ +++GS D +KL++ + H+ WV
Sbjct: 48 KGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSC 107
Query: 138 VAFSPDGKR--FVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSED 195
V FSP+ VS D+ V+VW+L + + + H + ++VS
Sbjct: 108 VRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL----------NTVTVS-- 155
Query: 196 KGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPD 243
P +GG D +W K L+TL+G ++ + ++ SP+
Sbjct: 156 --PDGSLCASGGKDGQAMLWDLNEGK--HLYTLDGGDI-INALCFSPN 198
Score = 39.1 bits (87), Expect = 0.034
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 11 TLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGA--- 67
T+ SPDG SG G+ +++ + GK LD G ++ +SP+ ++ +
Sbjct: 151 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAATGPS 209
Query: 68 -----LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV 119
L+G I + ++ Q + + + SL +S D Q L G D ++++ V
Sbjct: 210 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 266
>BC025392-1|AAH25392.1| 620|Homo sapiens WD repeat domain 16
protein.
Length = 620
Score = 77.8 bits (183), Expect = 8e-14
Identities = 59/240 (24%), Positives = 108/240 (45%), Gaps = 21/240 (8%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF-TLSVAYSPDGKYIASGALDG 70
+DF DGK +IS N GKI F E+G+ V++ + ++A + D K + SG +G
Sbjct: 380 IDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEG 439
Query: 71 IINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
+ ++ + KL L+ H S+ + +++ +T S DG ++D+V +
Sbjct: 440 EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMI 499
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL-DSMQCQHTFKEHNDQVWGVKFNAESN 187
+ + V + P+ + ++ DR + W++ D + + + G+ E
Sbjct: 500 LANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEG- 557
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ VTGG D+LVKVW Y N+ E+ H GH + + +SP + I
Sbjct: 558 -------------VHFVTGGNDHLVKVWDY--NEGEVTHVGVGHSGNITRIRISPGNQYI 602
Score = 64.1 bits (149), Expect = 1e-09
Identities = 39/182 (21%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIF--GVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
D K VISG G++ ++ G ++ K E+ L + + + + + DG I
Sbjct: 428 DCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCII 487
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
+D+ + + + + + + +C+ P+ ++T D + ++V + L G S
Sbjct: 488 WDLVRLRRNQMILANTL-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSG 546
Query: 135 VLS-VAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
++ + + +G FV+G D V+VWD + + H H+ + ++ + + I+SVS
Sbjct: 547 SINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVS 606
Query: 194 ED 195
D
Sbjct: 607 AD 608
Score = 49.6 bits (113), Expect = 2e-05
Identities = 55/254 (21%), Positives = 103/254 (40%), Gaps = 21/254 (8%)
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSG-HASWVLSVAFSPDGKRFVS 149
M+ + F D + +++ +DG ++ + L ++ H V ++A + D KR +S
Sbjct: 375 MTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVIS 434
Query: 150 GSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGG 207
G + VRVW + + + + KEH V ++ + + ++ S D T
Sbjct: 435 GGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDG--------TCI 486
Query: 208 LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI 267
+ +LV++ N++ L +TL V P+ I G I
Sbjct: 487 IWDLVRL---RRNQMILANTL------FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVI 537
Query: 268 REIQTD-SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSP 326
RE++ S + + + +G TGG+ V V+ G V V I + SP
Sbjct: 538 RELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISP 597
Query: 327 DGRYIASGAEGGSV 340
+YI S + G++
Sbjct: 598 GNQYIVSVSADGAI 611
Score = 48.8 bits (111), Expect = 4e-05
Identities = 43/157 (27%), Positives = 74/157 (47%), Gaps = 12/157 (7%)
Query: 16 PDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI---- 71
PD +H+I +LI + + K++ L G +A S G+YIASG + +
Sbjct: 34 PDQEHMIYPLGC-TVLIQAINT-KEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKV 91
Query: 72 -INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLL--LTGSDDGHMKLYDVVHAN-LAGT 127
I ++D +L+ L H I +L FSP+ L L G DDG + ++ + + + G+
Sbjct: 92 DIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGS 151
Query: 128 LSG--HASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
+ + +V FS + + T+RVW+LD
Sbjct: 152 PAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELD 188
Score = 48.4 bits (110), Expect = 6e-05
Identities = 33/144 (22%), Positives = 64/144 (44%), Gaps = 2/144 (1%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+ + ++ S G +I+ + ++ Q++ F V Y P+ I + D I ++
Sbjct: 472 NNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VCYHPEEFQIITSGTDRKIAYWE 530
Query: 77 VAQGKLVHTLEGHAM-SIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
V G ++ LEG SI + + + +TG +D +K++D + GH+ +
Sbjct: 531 VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNI 590
Query: 136 LSVAFSPDGKRFVSGSADRTVRVW 159
+ SP + VS SAD + W
Sbjct: 591 TRIRISPGNQYIVSVSADGAILRW 614
Score = 39.1 bits (87), Expect = 0.034
Identities = 22/100 (22%), Positives = 51/100 (51%), Gaps = 1/100 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGII 72
+ P+ +I+ KI + V G + L+ +++ + + +G + +G D ++
Sbjct: 510 YHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLV 569
Query: 73 NIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
++D +G++ H GH+ +I + SP +Q +++ S DG
Sbjct: 570 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADG 609
Score = 36.7 bits (81), Expect = 0.18
Identities = 39/133 (29%), Positives = 57/133 (42%), Gaps = 11/133 (8%)
Query: 304 INGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGG-----SVYLFDVSQGKMLHTIEAHA 358
IN L G + +A S G YIASG + L+D ++L + H
Sbjct: 52 INTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKVDIILWDYKNRELLARLSLHK 111
Query: 359 QAVRSLAFSPKTKLLAS--ASNDGYVNVYNI--ESAALQNKLD--HKCWAVSVCFSPDGQ 412
+ +LAFSP L S +DG V V++I A + + A +V FS
Sbjct: 112 GKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRD 171
Query: 413 RMATSAADGSIRV 425
M +A +G+IRV
Sbjct: 172 EMFMTAGNGTIRV 184
Score = 31.1 bits (67), Expect = 9.0
Identities = 44/265 (16%), Positives = 102/265 (38%), Gaps = 8/265 (3%)
Query: 212 VKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQ 271
++VW +N+ ELL + M + DG++I G+ + I
Sbjct: 356 IRVWHTSSNR-ELLR-ITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVIN 413
Query: 272 TDSS-DMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDKVLDTRGKFIMSVAWSPDG 328
+ I + D +V +GG G+V V+ G +++ L + + +
Sbjct: 414 NAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNN 473
Query: 329 RYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE 388
+ + G+ ++D+ + + I A+ + + + P+ + ++ D + + +
Sbjct: 474 EECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAYWEVF 532
Query: 389 SAALQNKLDHKCWAV--SVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG 446
+ +L+ + + +G T D ++V E V H H+ +
Sbjct: 533 DGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITR 592
Query: 447 VQFNADGSKLVSVSKDKSINIYECP 471
++ + +VSVS D +I ++ P
Sbjct: 593 IRISPGNQYIVSVSADGAILRWKYP 617
>AK094847-1|BAC04435.1| 630|Homo sapiens protein ( Homo sapiens
cDNA FLJ37528 fis, clone BRCAN2012408. ).
Length = 630
Score = 77.8 bits (183), Expect = 8e-14
Identities = 59/240 (24%), Positives = 108/240 (45%), Gaps = 21/240 (8%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF-TLSVAYSPDGKYIASGALDG 70
+DF DGK +IS N GKI F E+G+ V++ + ++A + D K + SG +G
Sbjct: 390 IDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEG 449
Query: 71 IINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
+ ++ + KL L+ H S+ + +++ +T S DG ++D+V +
Sbjct: 450 EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMI 509
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL-DSMQCQHTFKEHNDQVWGVKFNAESN 187
+ + V + P+ + ++ DR + W++ D + + + G+ E
Sbjct: 510 LANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEG- 567
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ VTGG D+LVKVW Y N+ E+ H GH + + +SP + I
Sbjct: 568 -------------VHFVTGGNDHLVKVWDY--NEGEVTHVGVGHSGNITRIRISPGNQYI 612
Score = 64.1 bits (149), Expect = 1e-09
Identities = 39/182 (21%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIF--GVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
D K VISG G++ ++ G ++ K E+ L + + + + + DG I
Sbjct: 438 DCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCII 497
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
+D+ + + + + + + +C+ P+ ++T D + ++V + L G S
Sbjct: 498 WDLVRLRRNQMILANTL-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSG 556
Query: 135 VLS-VAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
++ + + +G FV+G D V+VWD + + H H+ + ++ + + I+SVS
Sbjct: 557 SINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVS 616
Query: 194 ED 195
D
Sbjct: 617 AD 618
Score = 49.6 bits (113), Expect = 2e-05
Identities = 55/254 (21%), Positives = 103/254 (40%), Gaps = 21/254 (8%)
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSG-HASWVLSVAFSPDGKRFVS 149
M+ + F D + +++ +DG ++ + L ++ H V ++A + D KR +S
Sbjct: 385 MTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVIS 444
Query: 150 GSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGG 207
G + VRVW + + + + KEH V ++ + + ++ S D T
Sbjct: 445 GGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDG--------TCI 496
Query: 208 LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI 267
+ +LV++ N++ L +TL V P+ I G I
Sbjct: 497 IWDLVRL---RRNQMILANTL------FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVI 547
Query: 268 REIQTD-SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSP 326
RE++ S + + + +G TGG+ V V+ G V V I + SP
Sbjct: 548 RELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISP 607
Query: 327 DGRYIASGAEGGSV 340
+YI S + G++
Sbjct: 608 GNQYIVSVSADGAI 621
Score = 48.8 bits (111), Expect = 4e-05
Identities = 43/157 (27%), Positives = 74/157 (47%), Gaps = 12/157 (7%)
Query: 16 PDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI---- 71
PD +H+I +LI + + K++ L G +A S G+YIASG + +
Sbjct: 44 PDQEHMIYPLGC-TVLIQAINT-KEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKA 101
Query: 72 -INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLL--LTGSDDGHMKLYDVVHAN-LAGT 127
I ++D +L+ L H I +L FSP+ L L G DDG + ++ + + + G+
Sbjct: 102 DIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGS 161
Query: 128 LSG--HASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
+ + +V FS + + T+RVW+LD
Sbjct: 162 PAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELD 198
Score = 48.4 bits (110), Expect = 6e-05
Identities = 33/144 (22%), Positives = 64/144 (44%), Gaps = 2/144 (1%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+ + ++ S G +I+ + ++ Q++ F V Y P+ I + D I ++
Sbjct: 482 NNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VCYHPEEFQIITSGTDRKIAYWE 540
Query: 77 VAQGKLVHTLEGHAM-SIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
V G ++ LEG SI + + + +TG +D +K++D + GH+ +
Sbjct: 541 VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNI 600
Query: 136 LSVAFSPDGKRFVSGSADRTVRVW 159
+ SP + VS SAD + W
Sbjct: 601 TRIRISPGNQYIVSVSADGAILRW 624
Score = 39.1 bits (87), Expect = 0.034
Identities = 22/100 (22%), Positives = 51/100 (51%), Gaps = 1/100 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGII 72
+ P+ +I+ KI + V G + L+ +++ + + +G + +G D ++
Sbjct: 520 YHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLV 579
Query: 73 NIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
++D +G++ H GH+ +I + SP +Q +++ S DG
Sbjct: 580 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADG 619
Score = 37.9 bits (84), Expect = 0.078
Identities = 39/133 (29%), Positives = 57/133 (42%), Gaps = 11/133 (8%)
Query: 304 INGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEG-----GSVYLFDVSQGKMLHTIEAHA 358
IN L G + +A S G YIASG + L+D ++L + H
Sbjct: 62 INTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHK 121
Query: 359 QAVRSLAFSPKTKLLAS--ASNDGYVNVYNI--ESAALQNKLD--HKCWAVSVCFSPDGQ 412
+ +LAFSP L S +DG V V++I A + + A +V FS
Sbjct: 122 GKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRD 181
Query: 413 RMATSAADGSIRV 425
M +A +G+IRV
Sbjct: 182 EMFMTAGNGTIRV 194
Score = 31.1 bits (67), Expect = 9.0
Identities = 44/265 (16%), Positives = 102/265 (38%), Gaps = 8/265 (3%)
Query: 212 VKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQ 271
++VW +N+ ELL + M + DG++I G+ + I
Sbjct: 366 IRVWHTSSNR-ELLR-ITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVIN 423
Query: 272 TDSS-DMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDKVLDTRGKFIMSVAWSPDG 328
+ I + D +V +GG G+V V+ G +++ L + + +
Sbjct: 424 NAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNN 483
Query: 329 RYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE 388
+ + G+ ++D+ + + I A+ + + + P+ + ++ D + + +
Sbjct: 484 EECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAYWEVF 542
Query: 389 SAALQNKLDHKCWAV--SVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG 446
+ +L+ + + +G T D ++V E V H H+ +
Sbjct: 543 DGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITR 602
Query: 447 VQFNADGSKLVSVSKDKSINIYECP 471
++ + +VSVS D +I ++ P
Sbjct: 603 IRISPGNQYIVSVSADGAILRWKYP 627
>AK074435-1|BAB85083.1| 412|Homo sapiens protein ( Homo sapiens
cDNA FLJ23855 fis, clone LNG06370. ).
Length = 412
Score = 77.8 bits (183), Expect = 8e-14
Identities = 59/240 (24%), Positives = 108/240 (45%), Gaps = 21/240 (8%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF-TLSVAYSPDGKYIASGALDG 70
+DF DGK +IS N GKI F E+G+ V++ + ++A + D K + SG +G
Sbjct: 172 IDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEG 231
Query: 71 IINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
+ ++ + KL L+ H S+ + +++ +T S DG ++D+V +
Sbjct: 232 EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMI 291
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL-DSMQCQHTFKEHNDQVWGVKFNAESN 187
+ + V + P+ + ++ DR + W++ D + + + G+ E
Sbjct: 292 LANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEG- 349
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ VTGG D+LVKVW Y N+ E+ H GH + + +SP + I
Sbjct: 350 -------------VHFVTGGNDHLVKVWDY--NEGEVTHVGVGHSGNITRIRISPGNQYI 394
Score = 64.1 bits (149), Expect = 1e-09
Identities = 39/182 (21%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIF--GVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
D K VISG G++ ++ G ++ K E+ L + + + + + DG I
Sbjct: 220 DCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCII 279
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
+D+ + + + + + + +C+ P+ ++T D + ++V + L G S
Sbjct: 280 WDLVRLRRNQMILANTL-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSG 338
Query: 135 VLS-VAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
++ + + +G FV+G D V+VWD + + H H+ + ++ + + I+SVS
Sbjct: 339 SINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVS 398
Query: 194 ED 195
D
Sbjct: 399 AD 400
Score = 49.6 bits (113), Expect = 2e-05
Identities = 55/254 (21%), Positives = 103/254 (40%), Gaps = 21/254 (8%)
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSG-HASWVLSVAFSPDGKRFVS 149
M+ + F D + +++ +DG ++ + L ++ H V ++A + D KR +S
Sbjct: 167 MTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVIS 226
Query: 150 GSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGG 207
G + VRVW + + + + KEH V ++ + + ++ S D T
Sbjct: 227 GGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDG--------TCI 278
Query: 208 LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI 267
+ +LV++ N++ L +TL V P+ I G I
Sbjct: 279 IWDLVRL---RRNQMILANTL------FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVI 329
Query: 268 REIQTD-SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSP 326
RE++ S + + + +G TGG+ V V+ G V V I + SP
Sbjct: 330 RELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISP 389
Query: 327 DGRYIASGAEGGSV 340
+YI S + G++
Sbjct: 390 GNQYIVSVSADGAI 403
Score = 48.4 bits (110), Expect = 6e-05
Identities = 33/144 (22%), Positives = 64/144 (44%), Gaps = 2/144 (1%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+ + ++ S G +I+ + ++ Q++ F V Y P+ I + D I ++
Sbjct: 264 NNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VCYHPEEFQIITSGTDRKIAYWE 322
Query: 77 VAQGKLVHTLEGHAM-SIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
V G ++ LEG SI + + + +TG +D +K++D + GH+ +
Sbjct: 323 VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNI 382
Query: 136 LSVAFSPDGKRFVSGSADRTVRVW 159
+ SP + VS SAD + W
Sbjct: 383 TRIRISPGNQYIVSVSADGAILRW 406
Score = 39.1 bits (87), Expect = 0.034
Identities = 22/100 (22%), Positives = 51/100 (51%), Gaps = 1/100 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGII 72
+ P+ +I+ KI + V G + L+ +++ + + +G + +G D ++
Sbjct: 302 YHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLV 361
Query: 73 NIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
++D +G++ H GH+ +I + SP +Q +++ S DG
Sbjct: 362 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADG 401
Score = 31.1 bits (67), Expect = 9.0
Identities = 44/265 (16%), Positives = 102/265 (38%), Gaps = 8/265 (3%)
Query: 212 VKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQ 271
++VW +N+ ELL + M + DG++I G+ + I
Sbjct: 148 IRVWHTSSNR-ELLR-ITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVIN 205
Query: 272 TDSS-DMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDKVLDTRGKFIMSVAWSPDG 328
+ I + D +V +GG G+V V+ G +++ L + + +
Sbjct: 206 NAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNN 265
Query: 329 RYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE 388
+ + G+ ++D+ + + I A+ + + + P+ + ++ D + + +
Sbjct: 266 EECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAYWEVF 324
Query: 389 SAALQNKLDHKCWAV--SVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG 446
+ +L+ + + +G T D ++V E V H H+ +
Sbjct: 325 DGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITR 384
Query: 447 VQFNADGSKLVSVSKDKSINIYECP 471
++ + +VSVS D +I ++ P
Sbjct: 385 IRISPGNQYIVSVSADGAILRWKYP 409
>AC006011-2|AAX82033.1| 1336|Homo sapiens unknown protein.
Length = 1336
Score = 77.8 bits (183), Expect = 8e-14
Identities = 66/295 (22%), Positives = 125/295 (42%), Gaps = 22/295 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + ++P+G+ +++G+++G+ ++ + E +L ++ +S + ++ +
Sbjct: 122 VFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADH 181
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
G + + V + H +IR FSP T SDDG ++++D + + L
Sbjct: 182 GGYVKYWQSNMNN-VKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERIL 240
Query: 129 SGHASWVLSVAFSPDGKRFVSGSAD--RTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
GH + V V + P VSGS D + ++ WD + Q T H + V VK N
Sbjct: 241 RGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNG 300
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N +++T D+L K++ N K E L GH+ +VA P E
Sbjct: 301 N--------------WLLTASRDHLCKLFDIRNLK-EELQVFRGHKKEATAVAWHPVHEG 345
Query: 247 I-AXXXXXXXXXXXXXXXGQKIREIQTDSSDM-WKIVFSPDGSQVATGG--HTGK 297
+ A +++ ++ M W + + P G + +G HT K
Sbjct: 346 LFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSK 400
Score = 62.1 bits (144), Expect = 4e-09
Identities = 41/191 (21%), Positives = 89/191 (46%), Gaps = 4/191 (2%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVY 341
++P+G ++ TG +G+ T++ + + +L + ++ WS + ++ + GG V
Sbjct: 127 WTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVK 186
Query: 342 LFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKC 400
+ S + +AH +A+R +FSP A+ S+DG V +++ + L H
Sbjct: 187 YWQ-SNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGA 245
Query: 401 WAVSVCFSPDGQRMATSAADGS--IRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVS 458
V + P + + + D I+ + + L T H + V V+ N +G+ L++
Sbjct: 246 DVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLT 305
Query: 459 VSKDKSINIYE 469
S+D +++
Sbjct: 306 ASRDHLCKLFD 316
Score = 56.8 bits (131), Expect = 2e-07
Identities = 63/288 (21%), Positives = 115/288 (39%), Gaps = 24/288 (8%)
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVR 157
++P+ + L+TG+ G L++ + N L H S V ++ +S + ++ V+
Sbjct: 127 WTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVK 186
Query: 158 VWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSY 217
W +M F+ H + + F+ NK + S+D V++W +
Sbjct: 187 YWQ-SNMNNVKMFQAHKEAIREASFSPTDNKFATCSDD--------------GTVRIWDF 231
Query: 218 ENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX--XGQKIREIQTDSS 275
E + L GH V V P + GQ + + +
Sbjct: 232 LRCHEERI--LRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKN 289
Query: 276 DMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD-KVLDTRGKFIMSVAWSP--DGRYIA 332
+ ++ + +G+ + T ++ I N + +V K +VAW P +G + A
Sbjct: 290 TVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLF-A 348
Query: 333 SGAEGGSVYLFDVSQGKMLHTIE-AHAQAVRSLAFSPKTKLLASASND 379
SG GS+ + V K + +E AH + SLA+ P +L S SND
Sbjct: 349 SGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSND 396
Score = 54.8 bits (126), Expect = 6e-07
Identities = 49/231 (21%), Positives = 93/231 (40%), Gaps = 8/231 (3%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P +VTG +W+ E + L+ H+ PV ++ S + +
Sbjct: 129 PEGRRLVTGASSGEFTLWNGLTFNFETI--LQAHDSPVRAMTWSHNDMWMLTADHGGYVK 186
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
++ Q + + FSP ++ AT G V ++ + +++L G
Sbjct: 187 YWQSNMNN-VKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGA 245
Query: 318 FIMSVAWSPDGRYIASGAEGGS--VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
+ V W P + SG++ + +D G+ L T+ AH V + + L +
Sbjct: 246 DVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLT 305
Query: 376 ASNDGYVNVYNIES--AALQNKLDHKCWAVSVCFSPDGQRM-ATSAADGSI 423
AS D +++I + LQ HK A +V + P + + A+ +DGS+
Sbjct: 306 ASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSL 356
Score = 54.0 bits (124), Expect = 1e-06
Identities = 28/107 (26%), Positives = 51/107 (47%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V W+P+GR + +GA G L++ ++AH VR++ +S + +A +
Sbjct: 122 VFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADH 181
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
GYV + ++ HK FSP + AT + DG++R+
Sbjct: 182 GGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRI 228
Score = 53.6 bits (123), Expect = 1e-06
Identities = 38/157 (24%), Positives = 69/157 (43%), Gaps = 5/157 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGK--ILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
DV +D+ P V+SGS + I + ++G+ L + V + +G ++ +
Sbjct: 246 DVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLT 305
Query: 66 GALDGIINIFDVAQGKL-VHTLEGHAMSIRSLCFSPDSQ-LLLTGSDDGHMKLYDV-VHA 122
+ D + +FD+ K + GH ++ + P + L +G DG + + V V
Sbjct: 306 ASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEK 365
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ G H + S+A+ P G SGS D T + W
Sbjct: 366 EVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Score = 52.4 bits (120), Expect = 3e-06
Identities = 48/202 (23%), Positives = 84/202 (41%), Gaps = 9/202 (4%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
MF+ + FSP + S+ G + I+ +E++L G V + P
Sbjct: 197 MFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTK 256
Query: 61 KYIASGALDG--IINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ SG+ D I +D G+ + TL H ++ + + + LLT S D KL+D
Sbjct: 257 GLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFD 316
Query: 119 VVHANLAGTLS---GHASWVLSVAFSPDGK-RFVSGSADRTVRVWDLD-SMQCQHTFKEH 173
+ NL L GH +VA+ P + F SG +D ++ W + + H
Sbjct: 317 I--RNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAH 374
Query: 174 NDQVWGVKFNAESNKIISVSED 195
+W + ++ + + S S D
Sbjct: 375 EGMIWSLAWHPLGHILCSGSND 396
>AB065281-1|BAB83743.1| 620|Homo sapiens WDR16 protein.
Length = 620
Score = 77.8 bits (183), Expect = 8e-14
Identities = 59/240 (24%), Positives = 108/240 (45%), Gaps = 21/240 (8%)
Query: 12 LDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKF-TLSVAYSPDGKYIASGALDG 70
+DF DGK +IS N GKI F E+G+ V++ + ++A + D K + SG +G
Sbjct: 380 IDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEG 439
Query: 71 IINIFDVA--QGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
+ ++ + KL L+ H S+ + +++ +T S DG ++D+V +
Sbjct: 440 EVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMI 499
Query: 129 SGHASWVLSVAFSPDGKRFVSGSADRTVRVWDL-DSMQCQHTFKEHNDQVWGVKFNAESN 187
+ + V + P+ + ++ DR + W++ D + + + G+ E
Sbjct: 500 LANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEG- 557
Query: 188 KIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETI 247
+ VTGG D+LVKVW Y N+ E+ H GH + + +SP + I
Sbjct: 558 -------------VHFVTGGNDHLVKVWDY--NEGEVTHVGVGHSGNITRIRISPGNQYI 602
Score = 64.1 bits (149), Expect = 1e-09
Identities = 39/182 (21%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 17 DGKHVISGSNAGKILIF--GVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINI 74
D K VISG G++ ++ G ++ K E+ L + + + + + DG I
Sbjct: 428 DCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCII 487
Query: 75 FDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASW 134
+D+ + + + + + + +C+ P+ ++T D + ++V + L G S
Sbjct: 488 WDLVRLRRNQMILANTL-FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSG 546
Query: 135 VLS-VAFSPDGKRFVSGSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVS 193
++ + + +G FV+G D V+VWD + + H H+ + ++ + + I+SVS
Sbjct: 547 SINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVS 606
Query: 194 ED 195
D
Sbjct: 607 AD 608
Score = 49.6 bits (113), Expect = 2e-05
Identities = 55/254 (21%), Positives = 103/254 (40%), Gaps = 21/254 (8%)
Query: 91 MSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSG-HASWVLSVAFSPDGKRFVS 149
M+ + F D + +++ +DG ++ + L ++ H V ++A + D KR +S
Sbjct: 375 MTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVIS 434
Query: 150 GSADRTVRVWDL--DSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGG 207
G + VRVW + + + + KEH V ++ + + ++ S D T
Sbjct: 435 GGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDG--------TCI 486
Query: 208 LDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKI 267
+ +LV++ N++ L +TL V P+ I G I
Sbjct: 487 IWDLVRL---RRNQMILANTL------FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVI 537
Query: 268 REIQTD-SSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSP 326
RE++ S + + + +G TGG+ V V+ G V V I + SP
Sbjct: 538 RELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISP 597
Query: 327 DGRYIASGAEGGSV 340
+YI S + G++
Sbjct: 598 GNQYIVSVSADGAI 611
Score = 48.8 bits (111), Expect = 4e-05
Identities = 43/157 (27%), Positives = 74/157 (47%), Gaps = 12/157 (7%)
Query: 16 PDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGI---- 71
PD +H+I +LI + + K++ L G +A S G+YIASG + +
Sbjct: 34 PDQEHMIYPLGC-TVLIQAINT-KEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKA 91
Query: 72 -INIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLL--LTGSDDGHMKLYDVVHAN-LAGT 127
I ++D +L+ L H I +L FSP+ L L G DDG + ++ + + + G+
Sbjct: 92 DIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGS 151
Query: 128 LSG--HASWVLSVAFSPDGKRFVSGSADRTVRVWDLD 162
+ + +V FS + + T+RVW+LD
Sbjct: 152 PAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELD 188
Score = 48.4 bits (110), Expect = 6e-05
Identities = 33/144 (22%), Positives = 64/144 (44%), Gaps = 2/144 (1%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+ + ++ S G +I+ + ++ Q++ F V Y P+ I + D I ++
Sbjct: 472 NNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQC-VCYHPEEFQIITSGTDRKIAYWE 530
Query: 77 VAQGKLVHTLEGHAM-SIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWV 135
V G ++ LEG SI + + + +TG +D +K++D + GH+ +
Sbjct: 531 VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNI 590
Query: 136 LSVAFSPDGKRFVSGSADRTVRVW 159
+ SP + VS SAD + W
Sbjct: 591 TRIRISPGNQYIVSVSADGAILRW 614
Score = 39.1 bits (87), Expect = 0.034
Identities = 22/100 (22%), Positives = 51/100 (51%), Gaps = 1/100 (1%)
Query: 14 FSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLS-VAYSPDGKYIASGALDGII 72
+ P+ +I+ KI + V G + L+ +++ + + +G + +G D ++
Sbjct: 510 YHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLV 569
Query: 73 NIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDG 112
++D +G++ H GH+ +I + SP +Q +++ S DG
Sbjct: 570 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADG 609
Score = 37.9 bits (84), Expect = 0.078
Identities = 39/133 (29%), Positives = 57/133 (42%), Gaps = 11/133 (8%)
Query: 304 INGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEG-----GSVYLFDVSQGKMLHTIEAHA 358
IN L G + +A S G YIASG + L+D ++L + H
Sbjct: 52 INTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHK 111
Query: 359 QAVRSLAFSPKTKLLAS--ASNDGYVNVYNI--ESAALQNKLD--HKCWAVSVCFSPDGQ 412
+ +LAFSP L S +DG V V++I A + + A +V FS
Sbjct: 112 GKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRD 171
Query: 413 RMATSAADGSIRV 425
M +A +G+IRV
Sbjct: 172 EMFMTAGNGTIRV 184
Score = 31.1 bits (67), Expect = 9.0
Identities = 44/265 (16%), Positives = 102/265 (38%), Gaps = 8/265 (3%)
Query: 212 VKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXXXGQKIREIQ 271
++VW +N+ ELL + M + DG++I G+ + I
Sbjct: 356 IRVWHTSSNR-ELLR-ITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVIN 413
Query: 272 TDSS-DMWKIVFSPDGSQVATGGHTGKVTVY--GIINGTVDKVLDTRGKFIMSVAWSPDG 328
+ I + D +V +GG G+V V+ G +++ L + + +
Sbjct: 414 NAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNN 473
Query: 329 RYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIE 388
+ + G+ ++D+ + + I A+ + + + P+ + ++ D + + +
Sbjct: 474 EECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAYWEVF 532
Query: 389 SAALQNKLDHKCWAV--SVCFSPDGQRMATSAADGSIRVVLLEEFRVLHTFEEHTHIVCG 446
+ +L+ + + +G T D ++V E V H H+ +
Sbjct: 533 DGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITR 592
Query: 447 VQFNADGSKLVSVSKDKSINIYECP 471
++ + +VSVS D +I ++ P
Sbjct: 593 IRISPGNQYIVSVSADGAILRWKYP 617
>AB044749-1|BAB32435.1| 1336|Homo sapiens WDC146 protein.
Length = 1336
Score = 77.8 bits (183), Expect = 8e-14
Identities = 66/295 (22%), Positives = 125/295 (42%), Gaps = 22/295 (7%)
Query: 9 VWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGAL 68
V+ + ++P+G+ +++G+++G+ ++ + E +L ++ +S + ++ +
Sbjct: 122 VFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADH 181
Query: 69 DGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAGTL 128
G + + V + H +IR FSP T SDDG ++++D + + L
Sbjct: 182 GGYVKYWQSNMNN-VKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERIL 240
Query: 129 SGHASWVLSVAFSPDGKRFVSGSAD--RTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAES 186
GH + V V + P VSGS D + ++ WD + Q T H + V VK N
Sbjct: 241 RGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNG 300
Query: 187 NKIISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGET 246
N +++T D+L K++ N K E L GH+ +VA P E
Sbjct: 301 N--------------WLLTASRDHLCKLFDIRNLK-EELQVFRGHKKEATAVAWHPVHEG 345
Query: 247 I-AXXXXXXXXXXXXXXXGQKIREIQTDSSDM-WKIVFSPDGSQVATGG--HTGK 297
+ A +++ ++ M W + + P G + +G HT K
Sbjct: 346 LFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSK 400
Score = 62.1 bits (144), Expect = 4e-09
Identities = 41/191 (21%), Positives = 89/191 (46%), Gaps = 4/191 (2%)
Query: 282 FSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGKFIMSVAWSPDGRYIASGAEGGSVY 341
++P+G ++ TG +G+ T++ + + +L + ++ WS + ++ + GG V
Sbjct: 127 WTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVK 186
Query: 342 LFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAALQNKL-DHKC 400
+ S + +AH +A+R +FSP A+ S+DG V +++ + L H
Sbjct: 187 YWQ-SNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGA 245
Query: 401 WAVSVCFSPDGQRMATSAADGS--IRVVLLEEFRVLHTFEEHTHIVCGVQFNADGSKLVS 458
V + P + + + D I+ + + L T H + V V+ N +G+ L++
Sbjct: 246 DVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLT 305
Query: 459 VSKDKSINIYE 469
S+D +++
Sbjct: 306 ASRDHLCKLFD 316
Score = 56.8 bits (131), Expect = 2e-07
Identities = 63/288 (21%), Positives = 115/288 (39%), Gaps = 24/288 (8%)
Query: 98 FSPDSQLLLTGSDDGHMKLYDVVHANLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVR 157
++P+ + L+TG+ G L++ + N L H S V ++ +S + ++ V+
Sbjct: 127 WTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVK 186
Query: 158 VWDLDSMQCQHTFKEHNDQVWGVKFNAESNKIISVSEDKGPSKDYIVTGGLDNLVKVWSY 217
W +M F+ H + + F+ NK + S+D V++W +
Sbjct: 187 YWQ-SNMNNVKMFQAHKEAIREASFSPTDNKFATCSDD--------------GTVRIWDF 231
Query: 218 ENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXXXXXX--XGQKIREIQTDSS 275
E + L GH V V P + GQ + + +
Sbjct: 232 LRCHEERI--LRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKN 289
Query: 276 DMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVD-KVLDTRGKFIMSVAWSP--DGRYIA 332
+ ++ + +G+ + T ++ I N + +V K +VAW P +G + A
Sbjct: 290 TVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLF-A 348
Query: 333 SGAEGGSVYLFDVSQGKMLHTIE-AHAQAVRSLAFSPKTKLLASASND 379
SG GS+ + V K + +E AH + SLA+ P +L S SND
Sbjct: 349 SGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSND 396
Score = 54.8 bits (126), Expect = 6e-07
Identities = 49/231 (21%), Positives = 93/231 (40%), Gaps = 8/231 (3%)
Query: 198 PSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXX 257
P +VTG +W+ E + L+ H+ PV ++ S + +
Sbjct: 129 PEGRRLVTGASSGEFTLWNGLTFNFETI--LQAHDSPVRAMTWSHNDMWMLTADHGGYVK 186
Query: 258 XXXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGIINGTVDKVLDTRGK 317
++ Q + + FSP ++ AT G V ++ + +++L G
Sbjct: 187 YWQSNMNN-VKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGA 245
Query: 318 FIMSVAWSPDGRYIASGAEGGS--VYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLAS 375
+ V W P + SG++ + +D G+ L T+ AH V + + L +
Sbjct: 246 DVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLT 305
Query: 376 ASNDGYVNVYNIES--AALQNKLDHKCWAVSVCFSPDGQRM-ATSAADGSI 423
AS D +++I + LQ HK A +V + P + + A+ +DGS+
Sbjct: 306 ASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSL 356
Score = 54.0 bits (124), Expect = 1e-06
Identities = 28/107 (26%), Positives = 51/107 (47%)
Query: 319 IMSVAWSPDGRYIASGAEGGSVYLFDVSQGKMLHTIEAHAQAVRSLAFSPKTKLLASASN 378
+ V W+P+GR + +GA G L++ ++AH VR++ +S + +A +
Sbjct: 122 VFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADH 181
Query: 379 DGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRV 425
GYV + ++ HK FSP + AT + DG++R+
Sbjct: 182 GGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRI 228
Score = 53.6 bits (123), Expect = 1e-06
Identities = 38/157 (24%), Positives = 69/157 (43%), Gaps = 5/157 (3%)
Query: 8 DVWTLDFSPDGKHVISGSNAGK--ILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIAS 65
DV +D+ P V+SGS + I + ++G+ L + V + +G ++ +
Sbjct: 246 DVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLT 305
Query: 66 GALDGIINIFDVAQGKL-VHTLEGHAMSIRSLCFSPDSQ-LLLTGSDDGHMKLYDV-VHA 122
+ D + +FD+ K + GH ++ + P + L +G DG + + V V
Sbjct: 306 ASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEK 365
Query: 123 NLAGTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ G H + S+A+ P G SGS D T + W
Sbjct: 366 EVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Score = 52.4 bits (120), Expect = 3e-06
Identities = 48/202 (23%), Positives = 84/202 (41%), Gaps = 9/202 (4%)
Query: 1 MFETGLTDVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDG 60
MF+ + FSP + S+ G + I+ +E++L G V + P
Sbjct: 197 MFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTK 256
Query: 61 KYIASGALDG--IINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYD 118
+ SG+ D I +D G+ + TL H ++ + + + LLT S D KL+D
Sbjct: 257 GLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFD 316
Query: 119 VVHANLAGTLS---GHASWVLSVAFSPDGK-RFVSGSADRTVRVWDLD-SMQCQHTFKEH 173
+ NL L GH +VA+ P + F SG +D ++ W + + H
Sbjct: 317 I--RNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAH 374
Query: 174 NDQVWGVKFNAESNKIISVSED 195
+W + ++ + + S S D
Sbjct: 375 EGMIWSLAWHPLGHILCSGSND 396
>U05340-1|AAA19017.1| 499|Homo sapiens p55CDC protein.
Length = 499
Score = 77.4 bits (182), Expect = 1e-13
Identities = 67/281 (23%), Positives = 123/281 (43%), Gaps = 25/281 (8%)
Query: 20 HVISGSNAGKILIFGVESGKQEQVLDTR--GKFTLSVAYSPDGKYIASGALDGIINIFDV 77
+V++ + + ++ SG Q+L G++ SVA+ +G Y+A G + ++DV
Sbjct: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV-VHANLAGTLSGHASWVL 136
Q K + + H+ + SL ++ S +L +GS GH+ +DV V + TLSGH+ V
Sbjct: 256 QQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVC 313
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDL----DSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+ ++PDG+ SG D V VW TF +H V V + + +++
Sbjct: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
G D +++W+ + L ++ H V S+ SP + +
Sbjct: 374 G-----------GGTSDRHIRIWNVCSG--ACLSAVDAHSQ-VCSILWSPHYKELISGHG 419
Query: 253 XXXXXXX--XXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
K+ E++ +S + + SPDG+ VA+
Sbjct: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460
Score = 69.3 bits (162), Expect = 3e-11
Identities = 57/282 (20%), Positives = 130/282 (46%), Gaps = 12/282 (4%)
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
S ++ LDN V +WS + + L +E + SVA +G +A
Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDTRGK 317
+++R + + S+ + + S + +++G +G + + + + L +
Sbjct: 253 WDVQQQKRLRNMTSHSARVGSL--SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ 310
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGK----MLHTIEAHAQAVRSLAFSP-KTKL 372
+ + W+PDGR++ASG V ++ + G+ L T H AV+++A+ P ++ +
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 373 LASA--SNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
LA+ ++D ++ ++N+ S A + +D S+ +SP + + + ++V+ +
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430
Query: 431 FRVLHTFE--EHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ E HT V + + DG+ + S + D+++ ++ C
Sbjct: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
Score = 63.7 bits (148), Expect = 1e-09
Identities = 55/240 (22%), Positives = 115/240 (47%), Gaps = 25/240 (10%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+G ++ G+++ ++ ++ V+ K+ + + + S++++ ++SG+ G I+ D
Sbjct: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHD 294
Query: 77 VAQGKL-VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG----TLSGH 131
V + V TL GH+ + L ++PD + L +G +D + ++ T + H
Sbjct: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354
Query: 132 ASWVLSVAFSPDGKRFVS---GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
V +VA+ P ++ G++DR +R+W++ S C H+ QV + ++ +
Sbjct: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKE 413
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
+IS G N + +W Y + + L+GH V+S+ +SPDG T+A
Sbjct: 414 LISGH------------GFAQNQLVIWKYPT--MAKVAELKGHTSRVLSLTMSPDGATVA 459
Score = 62.9 bits (146), Expect = 2e-09
Identities = 48/161 (29%), Positives = 81/161 (50%), Gaps = 10/161 (6%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKF---TLSVAYSP-DGKY 62
+V L ++PDG+H+ SG N + ++ G+ V L T + +VA+ P
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 63 IASGA--LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+A+G D I I++V G + ++ H+ + S+ +SP + L++G +L
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK 429
Query: 121 HANLA--GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ +A L GH S VLS+ SPDG S +AD T+R+W
Sbjct: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
Score = 50.0 bits (114), Expect = 2e-05
Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 16/191 (8%)
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDT---RGKFIMS-VAWSPDGRYIASGAEGGSVYL 342
SQ AT G + K Y I D++LD R + ++ V WS G +A + SVYL
Sbjct: 153 SQKATPGSSRKTCRY--IPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDN-SVYL 208
Query: 343 FDVSQGKMLHTI--EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAA-LQNKLDHK 399
+ S G +L + E + + S+A+ + LA ++ V +++++ L+N H
Sbjct: 209 WSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHS 268
Query: 400 CWAVSVCFSPDGQRMATSAADGSIRV--VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
S+ ++ +++ + G I V + E V T H+ VCG+++ DG L
Sbjct: 269 ARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVA-TLSGHSQEVCGLRWAPDGRHLA 325
Query: 458 SVSKDKSINIY 468
S D +N++
Sbjct: 326 SGGNDNLVNVW 336
>DQ473545-1|ABE96834.1| 499|Homo sapiens CDC20 cell division cycle
20 homolog protein.
Length = 499
Score = 77.4 bits (182), Expect = 1e-13
Identities = 67/281 (23%), Positives = 123/281 (43%), Gaps = 25/281 (8%)
Query: 20 HVISGSNAGKILIFGVESGKQEQVLDTR--GKFTLSVAYSPDGKYIASGALDGIINIFDV 77
+V++ + + ++ SG Q+L G++ SVA+ +G Y+A G + ++DV
Sbjct: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV-VHANLAGTLSGHASWVL 136
Q K + + H+ + SL ++ S +L +GS GH+ +DV V + TLSGH+ V
Sbjct: 256 QQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVC 313
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDL----DSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+ ++PDG+ SG D V VW TF +H V V + + +++
Sbjct: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
G D +++W+ + L ++ H V S+ SP + +
Sbjct: 374 G-----------GGTSDRHIRIWNVCSG--ACLSAVDAHSQ-VCSILWSPHYKELISGHG 419
Query: 253 XXXXXXX--XXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
K+ E++ +S + + SPDG+ VA+
Sbjct: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460
Score = 69.3 bits (162), Expect = 3e-11
Identities = 57/282 (20%), Positives = 130/282 (46%), Gaps = 12/282 (4%)
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
S ++ LDN V +WS + + L +E + SVA +G +A
Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDTRGK 317
+++R + + S+ + + S + +++G +G + + + + L +
Sbjct: 253 WDVQQQKRLRNMTSHSARVGSL--SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ 310
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGK----MLHTIEAHAQAVRSLAFSP-KTKL 372
+ + W+PDGR++ASG V ++ + G+ L T H AV+++A+ P ++ +
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 373 LASA--SNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
LA+ ++D ++ ++N+ S A + +D S+ +SP + + + ++V+ +
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430
Query: 431 FRVLHTFE--EHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ E HT V + + DG+ + S + D+++ ++ C
Sbjct: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
Score = 63.7 bits (148), Expect = 1e-09
Identities = 55/240 (22%), Positives = 115/240 (47%), Gaps = 25/240 (10%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+G ++ G+++ ++ ++ V+ K+ + + + S++++ ++SG+ G I+ D
Sbjct: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHD 294
Query: 77 VAQGKL-VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG----TLSGH 131
V + V TL GH+ + L ++PD + L +G +D + ++ T + H
Sbjct: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354
Query: 132 ASWVLSVAFSPDGKRFVS---GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
V +VA+ P ++ G++DR +R+W++ S C H+ QV + ++ +
Sbjct: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKE 413
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
+IS G N + +W Y + + L+GH V+S+ +SPDG T+A
Sbjct: 414 LISGH------------GFAQNQLVIWKYPT--MAKVAELKGHTSRVLSLTMSPDGATVA 459
Score = 62.9 bits (146), Expect = 2e-09
Identities = 48/161 (29%), Positives = 81/161 (50%), Gaps = 10/161 (6%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKF---TLSVAYSP-DGKY 62
+V L ++PDG+H+ SG N + ++ G+ V L T + +VA+ P
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 63 IASGA--LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+A+G D I I++V G + ++ H+ + S+ +SP + L++G +L
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK 429
Query: 121 HANLA--GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ +A L GH S VLS+ SPDG S +AD T+R+W
Sbjct: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
Score = 50.0 bits (114), Expect = 2e-05
Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 16/191 (8%)
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDT---RGKFIMS-VAWSPDGRYIASGAEGGSVYL 342
SQ AT G + K Y I D++LD R + ++ V WS G +A + SVYL
Sbjct: 153 SQKATPGSSRKTCRY--IPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDN-SVYL 208
Query: 343 FDVSQGKMLHTI--EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAA-LQNKLDHK 399
+ S G +L + E + + S+A+ + LA ++ V +++++ L+N H
Sbjct: 209 WSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHS 268
Query: 400 CWAVSVCFSPDGQRMATSAADGSIRV--VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
S+ ++ +++ + G I V + E V T H+ VCG+++ DG L
Sbjct: 269 ARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVA-TLSGHSQEVCGLRWAPDGRHLA 325
Query: 458 SVSKDKSINIY 468
S D +N++
Sbjct: 326 SGGNDNLVNVW 336
>BT007388-1|AAP36052.1| 499|Homo sapiens CDC20 cell division cycle
20 homolog (S. cerevisiae) protein.
Length = 499
Score = 77.4 bits (182), Expect = 1e-13
Identities = 67/281 (23%), Positives = 123/281 (43%), Gaps = 25/281 (8%)
Query: 20 HVISGSNAGKILIFGVESGKQEQVLDTR--GKFTLSVAYSPDGKYIASGALDGIINIFDV 77
+V++ + + ++ SG Q+L G++ SVA+ +G Y+A G + ++DV
Sbjct: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV-VHANLAGTLSGHASWVL 136
Q K + + H+ + SL ++ S +L +GS GH+ +DV V + TLSGH+ V
Sbjct: 256 QQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVC 313
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDL----DSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+ ++PDG+ SG D V VW TF +H V V + + +++
Sbjct: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
G D +++W+ + L ++ H V S+ SP + +
Sbjct: 374 G-----------GGTSDRHIRIWNVCSG--ACLSAVDAHSQ-VCSILWSPHYKELISGHG 419
Query: 253 XXXXXXX--XXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
K+ E++ +S + + SPDG+ VA+
Sbjct: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460
Score = 69.3 bits (162), Expect = 3e-11
Identities = 57/282 (20%), Positives = 130/282 (46%), Gaps = 12/282 (4%)
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
S ++ LDN V +WS + + L +E + SVA +G +A
Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDTRGK 317
+++R + + S+ + + S + +++G +G + + + + L +
Sbjct: 253 WDVQQQKRLRNMTSHSARVGSL--SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ 310
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGK----MLHTIEAHAQAVRSLAFSP-KTKL 372
+ + W+PDGR++ASG V ++ + G+ L T H AV+++A+ P ++ +
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 373 LASA--SNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
LA+ ++D ++ ++N+ S A + +D S+ +SP + + + ++V+ +
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430
Query: 431 FRVLHTFE--EHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ E HT V + + DG+ + S + D+++ ++ C
Sbjct: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
Score = 63.7 bits (148), Expect = 1e-09
Identities = 55/240 (22%), Positives = 115/240 (47%), Gaps = 25/240 (10%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+G ++ G+++ ++ ++ V+ K+ + + + S++++ ++SG+ G I+ D
Sbjct: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHD 294
Query: 77 VAQGKL-VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG----TLSGH 131
V + V TL GH+ + L ++PD + L +G +D + ++ T + H
Sbjct: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354
Query: 132 ASWVLSVAFSPDGKRFVS---GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
V +VA+ P ++ G++DR +R+W++ S C H+ QV + ++ +
Sbjct: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKE 413
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
+IS G N + +W Y + + L+GH V+S+ +SPDG T+A
Sbjct: 414 LISGH------------GFAQNQLVIWKYPT--MAKVAELKGHTSRVLSLTMSPDGATVA 459
Score = 62.9 bits (146), Expect = 2e-09
Identities = 48/161 (29%), Positives = 81/161 (50%), Gaps = 10/161 (6%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKF---TLSVAYSP-DGKY 62
+V L ++PDG+H+ SG N + ++ G+ V L T + +VA+ P
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 63 IASGA--LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+A+G D I I++V G + ++ H+ + S+ +SP + L++G +L
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK 429
Query: 121 HANLA--GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ +A L GH S VLS+ SPDG S +AD T+R+W
Sbjct: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
Score = 50.0 bits (114), Expect = 2e-05
Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 16/191 (8%)
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDT---RGKFIMS-VAWSPDGRYIASGAEGGSVYL 342
SQ AT G + K Y I D++LD R + ++ V WS G +A + SVYL
Sbjct: 153 SQKATPGSSRKTCRY--IPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDN-SVYL 208
Query: 343 FDVSQGKMLHTI--EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAA-LQNKLDHK 399
+ S G +L + E + + S+A+ + LA ++ V +++++ L+N H
Sbjct: 209 WSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHS 268
Query: 400 CWAVSVCFSPDGQRMATSAADGSIRV--VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
S+ ++ +++ + G I V + E V T H+ VCG+++ DG L
Sbjct: 269 ARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVA-TLSGHSQEVCGLRWAPDGRHLA 325
Query: 458 SVSKDKSINIY 468
S D +N++
Sbjct: 326 SGGNDNLVNVW 336
>BC110321-1|AAI10322.1| 499|Homo sapiens cell division cycle 20
homolog (S. cerevisiae) protein.
Length = 499
Score = 77.4 bits (182), Expect = 1e-13
Identities = 67/281 (23%), Positives = 123/281 (43%), Gaps = 25/281 (8%)
Query: 20 HVISGSNAGKILIFGVESGKQEQVLDTR--GKFTLSVAYSPDGKYIASGALDGIINIFDV 77
+V++ + + ++ SG Q+L G++ SVA+ +G Y+A G + ++DV
Sbjct: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV-VHANLAGTLSGHASWVL 136
Q K + + H+ + SL ++ S +L +GS GH+ +DV V + TLSGH+ V
Sbjct: 256 QQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVC 313
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDL----DSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+ ++PDG+ SG D V VW TF +H V V + + +++
Sbjct: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
G D +++W+ + L ++ H V S+ SP + +
Sbjct: 374 G-----------GGTSDRHIRIWNVCSG--ACLSAVDAHSQ-VCSILWSPHYKELISGHG 419
Query: 253 XXXXXXX--XXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
K+ E++ +S + + SPDG+ VA+
Sbjct: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460
Score = 69.3 bits (162), Expect = 3e-11
Identities = 57/282 (20%), Positives = 130/282 (46%), Gaps = 12/282 (4%)
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
S ++ LDN V +WS + + L +E + SVA +G +A
Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDTRGK 317
+++R + + S+ + + S + +++G +G + + + + L +
Sbjct: 253 WDVQQQKRLRNMTSHSARVGSL--SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ 310
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGK----MLHTIEAHAQAVRSLAFSP-KTKL 372
+ + W+PDGR++ASG V ++ + G+ L T H AV+++A+ P ++ +
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 373 LASA--SNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
LA+ ++D ++ ++N+ S A + +D S+ +SP + + + ++V+ +
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430
Query: 431 FRVLHTFE--EHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ E HT V + + DG+ + S + D+++ ++ C
Sbjct: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
Score = 63.7 bits (148), Expect = 1e-09
Identities = 55/240 (22%), Positives = 115/240 (47%), Gaps = 25/240 (10%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+G ++ G+++ ++ ++ V+ K+ + + + S++++ ++SG+ G I+ D
Sbjct: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHD 294
Query: 77 VAQGKL-VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG----TLSGH 131
V + V TL GH+ + L ++PD + L +G +D + ++ T + H
Sbjct: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354
Query: 132 ASWVLSVAFSPDGKRFVS---GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
V +VA+ P ++ G++DR +R+W++ S C H+ QV + ++ +
Sbjct: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKE 413
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
+IS G N + +W Y + + L+GH V+S+ +SPDG T+A
Sbjct: 414 LISGH------------GFAQNQLVIWKYPT--MAKVAELKGHTSRVLSLTMSPDGATVA 459
Score = 62.9 bits (146), Expect = 2e-09
Identities = 48/161 (29%), Positives = 81/161 (50%), Gaps = 10/161 (6%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKF---TLSVAYSP-DGKY 62
+V L ++PDG+H+ SG N + ++ G+ V L T + +VA+ P
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 63 IASGA--LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+A+G D I I++V G + ++ H+ + S+ +SP + L++G +L
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK 429
Query: 121 HANLA--GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ +A L GH S VLS+ SPDG S +AD T+R+W
Sbjct: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
Score = 50.0 bits (114), Expect = 2e-05
Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 16/191 (8%)
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDT---RGKFIMS-VAWSPDGRYIASGAEGGSVYL 342
SQ AT G + K Y I D++LD R + ++ V WS G +A + SVYL
Sbjct: 153 SQKATPGSSRKTCRY--IPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDN-SVYL 208
Query: 343 FDVSQGKMLHTI--EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAA-LQNKLDHK 399
+ S G +L + E + + S+A+ + LA ++ V +++++ L+N H
Sbjct: 209 WSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHS 268
Query: 400 CWAVSVCFSPDGQRMATSAADGSIRV--VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
S+ ++ +++ + G I V + E V T H+ VCG+++ DG L
Sbjct: 269 ARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVA-TLSGHSQEVCGLRWAPDGRHLA 325
Query: 458 SVSKDKSINIY 468
S D +N++
Sbjct: 326 SGGNDNLVNVW 336
>BC031294-1|AAH31294.1| 499|Homo sapiens cell division cycle 20
homolog (S. cerevisiae) protein.
Length = 499
Score = 77.4 bits (182), Expect = 1e-13
Identities = 67/281 (23%), Positives = 123/281 (43%), Gaps = 25/281 (8%)
Query: 20 HVISGSNAGKILIFGVESGKQEQVLDTR--GKFTLSVAYSPDGKYIASGALDGIINIFDV 77
+V++ + + ++ SG Q+L G++ SVA+ +G Y+A G + ++DV
Sbjct: 196 NVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV 255
Query: 78 AQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDV-VHANLAGTLSGHASWVL 136
Q K + + H+ + SL ++ S +L +GS GH+ +DV V + TLSGH+ V
Sbjct: 256 QQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVC 313
Query: 137 SVAFSPDGKRFVSGSADRTVRVWDL----DSMQCQHTFKEHNDQVWGVKFNAESNKIISV 192
+ ++PDG+ SG D V VW TF +H V V + + +++
Sbjct: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLAT 373
Query: 193 SEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXX 252
G D +++W+ + L ++ H V S+ SP + +
Sbjct: 374 G-----------GGTSDRHIRIWNVCSG--ACLSAVDAHSQ-VCSILWSPHYKELISGHG 419
Query: 253 XXXXXXX--XXXXGQKIREIQTDSSDMWKIVFSPDGSQVAT 291
K+ E++ +S + + SPDG+ VA+
Sbjct: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVAS 460
Score = 69.3 bits (162), Expect = 3e-11
Identities = 57/282 (20%), Positives = 130/282 (46%), Gaps = 12/282 (4%)
Query: 199 SKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIAXXXXXXXXXX 258
S ++ LDN V +WS + + L +E + SVA +G +A
Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252
Query: 259 XXXXXGQKIREIQTDSSDMWKIVFSPDGSQVATGGHTGKVTVYGI-INGTVDKVLDTRGK 317
+++R + + S+ + + S + +++G +G + + + + L +
Sbjct: 253 WDVQQQKRLRNMTSHSARVGSL--SWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQ 310
Query: 318 FIMSVAWSPDGRYIASGAEGGSVYLFDVSQGK----MLHTIEAHAQAVRSLAFSP-KTKL 372
+ + W+PDGR++ASG V ++ + G+ L T H AV+++A+ P ++ +
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 373 LASA--SNDGYVNVYNIESAALQNKLDHKCWAVSVCFSPDGQRMATSAADGSIRVVLLEE 430
LA+ ++D ++ ++N+ S A + +D S+ +SP + + + ++V+ +
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKY 430
Query: 431 FRVLHTFE--EHTHIVCGVQFNADGSKLVSVSKDKSINIYEC 470
+ E HT V + + DG+ + S + D+++ ++ C
Sbjct: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472
Score = 63.7 bits (148), Expect = 1e-09
Identities = 55/240 (22%), Positives = 115/240 (47%), Gaps = 25/240 (10%)
Query: 17 DGKHVISGSNAGKILIFGVESGKQEQVLDTRGKFTLSVAYSPDGKYIASGALDGIINIFD 76
+G ++ G+++ ++ ++ V+ K+ + + + S++++ ++SG+ G I+ D
Sbjct: 237 EGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHD 294
Query: 77 VAQGKL-VHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVVHANLAG----TLSGH 131
V + V TL GH+ + L ++PD + L +G +D + ++ T + H
Sbjct: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354
Query: 132 ASWVLSVAFSPDGKRFVS---GSADRTVRVWDLDSMQCQHTFKEHNDQVWGVKFNAESNK 188
V +VA+ P ++ G++DR +R+W++ S C H+ QV + ++ +
Sbjct: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKE 413
Query: 189 IISVSEDKGPSKDYIVTGGLDNLVKVWSYENNKLELLHTLEGHEMPVVSVAVSPDGETIA 248
+IS G N + +W Y + + L+GH V+S+ +SPDG T+A
Sbjct: 414 LISGH------------GFAQNQLVIWKYPT--MAKVAELKGHTSRVLSLTMSPDGATVA 459
Score = 62.9 bits (146), Expect = 2e-09
Identities = 48/161 (29%), Positives = 81/161 (50%), Gaps = 10/161 (6%)
Query: 8 DVWTLDFSPDGKHVISGSNAGKILIFGVESGKQEQV-LDTRGKF---TLSVAYSP-DGKY 62
+V L ++PDG+H+ SG N + ++ G+ V L T + +VA+ P
Sbjct: 311 EVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370
Query: 63 IASGA--LDGIINIFDVAQGKLVHTLEGHAMSIRSLCFSPDSQLLLTGSDDGHMKLYDVV 120
+A+G D I I++V G + ++ H+ + S+ +SP + L++G +L
Sbjct: 371 LATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK 429
Query: 121 HANLA--GTLSGHASWVLSVAFSPDGKRFVSGSADRTVRVW 159
+ +A L GH S VLS+ SPDG S +AD T+R+W
Sbjct: 430 YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
Score = 50.0 bits (114), Expect = 2e-05
Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 16/191 (8%)
Query: 287 SQVATGGHTGKVTVYGIINGTVDKVLDT---RGKFIMS-VAWSPDGRYIASGAEGGSVYL 342
SQ AT G + K Y I D++LD R + ++ V WS G +A + SVYL
Sbjct: 153 SQKATPGSSRKTCRY--IPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDN-SVYL 208
Query: 343 FDVSQGKMLHTI--EAHAQAVRSLAFSPKTKLLASASNDGYVNVYNIESAA-LQNKLDHK 399
+ S G +L + E + + S+A+ + LA ++ V +++++ L+N H
Sbjct: 209 WSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHS 268
Query: 400 CWAVSVCFSPDGQRMATSAADGSIRV--VLLEEFRVLHTFEEHTHIVCGVQFNADGSKLV 457
S+ ++ +++ + G I V + E V T H+ VCG+++ DG L
Sbjct: 269 ARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVA-TLSGHSQEVCGLRWAPDGRHLA 325
Query: 458 SVSKDKSINIY 468
S D +N++
Sbjct: 326 SGGNDNLVNVW 336
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.316 0.133 0.393
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 68,871,716
Number of Sequences: 224733
Number of extensions: 2731988
Number of successful extensions: 22502
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 927
Number of HSP's successfully gapped in prelim test: 374
Number of HSP's that attempted gapping in prelim test: 5409
Number of HSP's gapped (non-prelim): 9842
length of query: 482
length of database: 73,234,838
effective HSP length: 93
effective length of query: 389
effective length of database: 52,334,669
effective search space: 20358186241
effective search space used: 20358186241
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 67 (31.1 bits)
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