Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002355-TA|BGIBMGA002355-PA|IPR000672|Tetrahydrofolate
dehydrogenase/cyclohydrolase
(301 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 398 e-109
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 354 2e-96
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 341 2e-92
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 335 7e-91
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 273 4e-72
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 259 5e-68
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 257 3e-67
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 255 9e-67
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 254 3e-66
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 252 8e-66
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 251 1e-65
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 250 3e-65
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 248 1e-64
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 248 2e-64
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 247 2e-64
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 244 2e-63
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 242 7e-63
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 241 2e-62
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 241 2e-62
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 239 8e-62
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 235 8e-61
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 235 1e-60
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 234 2e-60
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 233 3e-60
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 231 2e-59
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 230 4e-59
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 230 4e-59
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 229 5e-59
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 227 4e-58
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 225 1e-57
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 225 1e-57
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 222 1e-56
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 220 4e-56
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 219 5e-56
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 218 1e-55
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 218 2e-55
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 217 2e-55
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 217 4e-55
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 216 5e-55
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 215 1e-54
UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes: Me... 214 2e-54
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 212 1e-53
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 211 2e-53
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 210 3e-53
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 208 1e-52
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 208 1e-52
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 208 2e-52
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 207 3e-52
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 206 5e-52
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 206 7e-52
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 205 1e-51
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 204 2e-51
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 203 4e-51
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 202 7e-51
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 202 7e-51
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 200 3e-50
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 196 8e-49
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 196 8e-49
UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147, w... 194 2e-48
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 194 2e-48
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 193 5e-48
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 190 3e-47
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 189 7e-47
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 185 1e-45
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 184 2e-45
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 177 3e-43
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 175 1e-42
UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycopla... 175 2e-42
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 173 4e-42
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 172 8e-42
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 172 8e-42
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 170 3e-41
UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes: Me... 168 2e-40
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 167 2e-40
UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes: ... 165 9e-40
UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes: Me... 165 2e-39
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 159 1e-37
UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes: ... 158 1e-37
UniRef50_A6LP88 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 157 3e-37
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 155 1e-36
UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes: Me... 155 1e-36
UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate dehydrogenase... 153 7e-36
UniRef50_A4M873 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 152 9e-36
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 151 2e-35
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 148 2e-34
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 147 3e-34
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 144 2e-33
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 140 3e-32
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 140 3e-32
UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1; ... 137 4e-31
UniRef50_UPI0000D9A063 Cluster: PREDICTED: similar to Bifunction... 125 1e-27
UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121... 124 4e-27
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 121 3e-26
UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes: Me... 119 1e-25
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 119 1e-25
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 114 2e-24
UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes: Me... 112 9e-24
UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate dehydrogenase... 105 2e-21
UniRef50_UPI00005A5066 Cluster: PREDICTED: similar to Bifunction... 101 3e-20
UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate dehydrogenase... 75 2e-12
UniRef50_A1ZUI3 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 72 2e-11
UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase... 71 3e-11
UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunction... 70 6e-11
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 65 2e-09
UniRef50_UPI00015563B5 Cluster: PREDICTED: similar to Mthfd2-pro... 63 1e-08
UniRef50_UPI000023D48A Cluster: hypothetical protein FG10624.1; ... 63 1e-08
UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate for... 62 1e-08
UniRef50_Q02046 Cluster: Methylenetetrahydrofolate dehydrogenase... 60 9e-08
UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase... 53 8e-06
UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate deh... 51 4e-05
UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1; Trepo... 50 1e-04
UniRef50_A6QZK7 Cluster: Putative uncharacterized protein; n=1; ... 46 0.001
UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergil... 44 0.005
UniRef50_Q9PQF4 Cluster: Methylenetetrahydrofolate dehydrogenase... 44 0.006
UniRef50_Q8ZSG1 Cluster: Alr7549 protein; n=3; Nostocaceae|Rep: ... 39 0.18
UniRef50_Q08352 Cluster: Alanine dehydrogenase; n=81; Bacteria|R... 38 0.24
UniRef50_P11864 Cluster: Uncharacterized protein yhaC; n=7; Ente... 38 0.32
UniRef50_P58339 Cluster: Ornithine cyclodeaminase 2; n=5; Proteo... 38 0.42
UniRef50_A0FRY0 Cluster: Aminotransferase class-III; n=1; Burkho... 37 0.55
UniRef50_A5K2D8 Cluster: Putative uncharacterized protein; n=1; ... 37 0.55
UniRef50_A7IBV4 Cluster: Putative uncharacterized protein; n=1; ... 36 0.97
UniRef50_Q4YPQ5 Cluster: Putative uncharacterized protein; n=4; ... 36 1.3
UniRef50_P76339 Cluster: Putative sensor-like histidine kinase y... 36 1.3
UniRef50_Q6LEW8 Cluster: Putative uncharacterized protein; n=1; ... 36 1.7
UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase... 35 3.0
UniRef50_Q0UVW9 Cluster: Putative uncharacterized protein; n=1; ... 35 3.0
UniRef50_UPI0000D56538 Cluster: PREDICTED: similar to activating... 34 3.9
UniRef50_Q83AZ8 Cluster: Ornithine cyclodeaminase; n=2; Coxiella... 34 3.9
UniRef50_Q47IC2 Cluster: Putative uncharacterized protein; n=1; ... 34 3.9
UniRef50_Q18E84 Cluster: ATP-dependent DNA helicase; n=1; Haloqu... 34 3.9
UniRef50_Q9TW65 Cluster: Dystrophin-1; n=4; root|Rep: Dystrophin... 34 3.9
UniRef50_A7DV73 Cluster: Putative uncharacterized protein vep13;... 34 5.2
UniRef50_A6VS59 Cluster: Short-chain dehydrogenase/reductase SDR... 33 6.8
UniRef50_A5MC89 Cluster: Putative uncharacterized protein; n=1; ... 33 6.8
UniRef50_A3SDC1 Cluster: Ornithine cyclodeaminase; n=2; Sulfitob... 33 6.8
UniRef50_A3DEC5 Cluster: Putative stage IV sporulation YqfD; n=1... 33 6.8
UniRef50_O74539 Cluster: Peroxide stress-activated histidine kin... 33 6.8
UniRef50_Q7N1T7 Cluster: Similarities with the N-terminal region... 33 9.0
UniRef50_Q62L13 Cluster: Hydrolase; n=16; Burkholderia|Rep: Hydr... 33 9.0
UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10... 33 9.0
UniRef50_Q7CTP3 Cluster: AGR_L_1807p; n=4; Proteobacteria|Rep: A... 33 9.0
UniRef50_A5USY0 Cluster: Shikimate/quinate 5-dehydrogenase; n=5;... 33 9.0
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 398 bits (979), Expect = e-109
Identities = 187/301 (62%), Positives = 248/301 (82%), Gaps = 3/301 (0%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLG-NRAPTIRCIIVGDDPASHTYVRNKVEAAKF 59
MA+++DGK +A +I+ EL+++I +W+ G NRAP + I++G+DPAS+TYV NK++AA
Sbjct: 32 MAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKMKAAAD 91
Query: 60 VGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDI 119
VGI + T +DITEEQLL I+ LN+D+SVDGILVQLPVP INER+VC++++ +KD+
Sbjct: 92 VGITSKTERYSADITEEQLLKRIEELNQDDSVDGILVQLPVPGHINERKVCNSVSCDKDV 151
Query: 120 DGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
DGF+ NIGRLC+D+ T++P T L V E++KR I+TFG+NAVV+GRSKNVGMPIAM+LH
Sbjct: 152 DGFNERNIGRLCLDMNTLIPCTPLGVQELIKRTEIETFGKNAVVVGRSKNVGMPIAMLLH 211
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
+D R+++ MDATVT+CHR+TP ++L +CR ADII+TATG+P LIKADMVK GA IID
Sbjct: 212 ADGRNDT-CAMDATVTMCHRFTPPEELARFCRTADIIVTATGVPGLIKADMVKEGAAIID 270
Query: 240 VGITRITD-ENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQAN 298
VGITR+ D E GK++LVGDVD++EV K+AG ITPVPGGVGPMTVAMLM NTF AA++ A+
Sbjct: 271 VGITRVKDPETGKNKLVGDVDFDEVRKVAGHITPVPGGVGPMTVAMLMKNTFIAAKNLAH 330
Query: 299 K 299
K
Sbjct: 331 K 331
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 354 bits (870), Expect = 2e-96
Identities = 166/294 (56%), Positives = 228/294 (77%), Gaps = 2/294 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG
Sbjct: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+IN+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D
Sbjct: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
HE G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVG
Sbjct: 217 GAHERP-GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 275
Query: 242 ITRITDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
I R+ D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+
Sbjct: 276 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 329
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 341 bits (837), Expect = 2e-92
Identities = 161/300 (53%), Positives = 219/300 (73%), Gaps = 1/300 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A I+DG +A ++ +E+K ++ + G + P + I+VG++PAS YV KV+AAK VG
Sbjct: 28 AAIIDGNGVADQVLEEVKAEVDEMTRNGEKRPKLIAILVGNNPASKAYVGRKVKAAKTVG 87
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I++ T+ + IT+E+LL E+Q LN+D +VDG+LVQLPVP+ I+ER VC A+ P KD+DG
Sbjct: 88 IESETLRFEDSITQEELLHEVQKLNDDPTVDGLLVQLPVPEHISEREVCQAVTPTKDVDG 147
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+ NIG L ++ I+PATAL V E++ R I TFG+NAVVIGRSK+VG PIA++LHSD
Sbjct: 148 FHLSNIGNLALNNKGIIPATALGVKELIVRSKIPTFGKNAVVIGRSKHVGFPIALLLHSD 207
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
E+ G+D T TICHRYTP+ +LE Y + ADI++ + G+P L+ +M+KPGA +IDVG
Sbjct: 208 GNGETA-GLDMTTTICHRYTPRVELERYTKLADIVVASAGVPGLVTKEMIKPGACVIDVG 266
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANKSN 301
I+RI GK RLVGDV+YE V +AG ITPVPGGVGPMTVAMLM NT A + + + N
Sbjct: 267 ISRIKTSEGKYRLVGDVNYESVKTVAGHITPVPGGVGPMTVAMLMKNTLFAIRLRKSLEN 326
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 335 bits (824), Expect = 7e-91
Identities = 159/300 (53%), Positives = 218/300 (72%), Gaps = 2/300 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A I+DGK +A +I+ ELK + W++ + P + I VG++PAS YV K++AA F+G
Sbjct: 110 AIIIDGKKIANKIQNELKITVDNWINDNKKRPKLVAIKVGNNPASKIYVEKKIKAANFIG 169
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I+ TI+ D +++ +++EI NLN+D +VDGILVQLP+ +NE+ VC AI P KD+DG
Sbjct: 170 IENYTIHLDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIKHMNEQEVCQAIIPSKDVDG 229
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+ N+G L ++ I+PATALAV E++ R NI+TFG+NAVV+GRSK+VG+PIA++LH D
Sbjct: 230 FHLENLGNLALNRNGIIPATALAVKELIIRNNIETFGKNAVVVGRSKHVGLPIALLLHGD 289
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
+ +G +D T TICHR+TP +LE + + AD+++ A G+P LI +M+KPGA IIDVG
Sbjct: 290 SKDRTG-ALDMTTTICHRHTPHTELEKFTKLADLVVVAAGIPGLITKEMIKPGACIIDVG 348
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANKSN 301
ITRI +N K ++VGDVD+E V IAG ITPVPGGVGPMTVAMLM NT AA SN
Sbjct: 349 ITRIKMDN-KYKIVGDVDFENVKSIAGYITPVPGGVGPMTVAMLMKNTILAANKNYENSN 407
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 273 bits (669), Expect = 4e-72
Identities = 135/294 (45%), Positives = 196/294 (66%), Gaps = 9/294 (3%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
++LDGK ++ EIK+E+ + + + G R P + ++VG D S TY+ +KV+A + VG
Sbjct: 6 KLLDGKKISGEIKQEIAAVVNELLEKGGRRPHLAGVLVGHDGGSETYMASKVKACEEVGF 65
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 122
+ I + D+TEE+LL+ + LN+D +VDG +VQLP+P I+E+++ +A+ P KD+DGF
Sbjct: 66 TSSLIRYEDDVTEEELLACVHRLNQDPTVDGFIVQLPLPKHIDEQKIIEAVDPRKDVDGF 125
Query: 123 HIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
H IN+GRL + LP V AT +VE+L+R+NI T G++ VV+GRS VG P++ +L +
Sbjct: 126 HPINVGRLSIGLPGFVSATPKGIVELLRRYNIPTRGKHCVVLGRSNIVGKPVSQLLL--Q 183
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
+ E G D T+TICH TP ++ C ADIII A G P+ + ADMVKPGA ++DVG
Sbjct: 184 KGEPG---DCTITICHSRTP--NIKEVCLTADIIIAALGQPEFLTADMVKPGAVVVDVGT 238
Query: 243 TRITDENGKS--RLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
T + D KS RL GDV ++EV+ ITPVPGGVGPMT+ LM NT A++
Sbjct: 239 TLVPDSTRKSGFRLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMSNTLLASK 292
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 259 bits (635), Expect = 5e-68
Identities = 120/223 (53%), Positives = 166/223 (74%), Gaps = 1/223 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA +I++E + + +WV G+R P + ++VGDDPASH+YV NK AA +G
Sbjct: 30 AVVISGRKLARQIREEARADVEKWVLTGHRRPHLSVVLVGDDPASHSYVLNKTRAAADIG 89
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I + TI + SDI+EE+LL I LN D+ VDG+LVQLP+P+ I+ER +C+A+AP KD+DG
Sbjct: 90 ISSETILKHSDISEEELLDLIDKLNTDHRVDGLLVQLPLPEHIDERTICNAVAPTKDVDG 149
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH++N+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D
Sbjct: 150 FHVVNVGRMCLDQSSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 209
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPK 224
RHE G DATVTI HRYTPK++L + + ADI+I A GL K
Sbjct: 210 GRHERP-GGDATVTISHRYTPKEQLCQHTKIADIVIAAAGLCK 251
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 257 bits (629), Expect = 3e-67
Identities = 134/301 (44%), Positives = 189/301 (62%), Gaps = 11/301 (3%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A+I+ G + EI E+K + + P + I+VG+ PAS +YV K++ A +G
Sbjct: 3 AKIISGTEIRKEILGEIKDAVTEMKDKYGTVPGLVTILVGESPASMSYVSLKIKTALSLG 62
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+ + + TE +LL+ I+ N D+S+ G+LVQLP+P INE+ + AI P+KD+D
Sbjct: 63 FYEVQESLSVETTEAELLALIEKYNNDDSIHGVLVQLPLPKHINEQNIITAIDPDKDVDA 122
Query: 122 FHIINIGRLCV--DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
FH +NIGRL + D +P T + EML R ++T G VV+GRS VG PIAMM+
Sbjct: 123 FHPVNIGRLMIGGDDVKFLPCTPAGIQEMLVRSGVETAGAEVVVVGRSNIVGKPIAMMM- 181
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
+ G+G +ATVTI H T L +CR ADI+I A G+P L+K + +KPGAT+ID
Sbjct: 182 ----AQKGIGANATVTIVH--TGSRDLATHCRRADILIVAAGVPNLVKPEWIKPGATVID 235
Query: 240 VGITRI--TDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQA 297
VG+ R+ E GK+ L GDVD+E V +IAG ITPVPGGVGPMT+AMLM NT +A + +
Sbjct: 236 VGVNRVGTNSETGKAILRGDVDFEAVKEIAGKITPVPGGVGPMTIAMLMKNTLASALAHS 295
Query: 298 N 298
+
Sbjct: 296 S 296
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 255 bits (625), Expect = 9e-67
Identities = 136/288 (47%), Positives = 186/288 (64%), Gaps = 11/288 (3%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A LDGK+LA I+++L + + + R+P + + VG+DPAS YVR K +A VG
Sbjct: 6 ATCLDGKSLAQSIERQLADHVRTFQAQWGRSPGLAVLRVGNDPASAVYVRAKEQACSRVG 65
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I + + + ITE LL++I LN+D VDGIL+QLP+P ++ R + AI P+KD+DG
Sbjct: 66 IQSFGAHLPATITEAALLAKITELNQDERVDGILLQLPLPPHLDPRPLLYAIHPDKDVDG 125
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
H N+GRL D P + T V+++L + ID GR+AVV+GRS VG P+A+ML
Sbjct: 126 LHPENLGRLVRDEPGLRSCTPAGVMQLLAAYGIDVVGRSAVVVGRSILVGKPLALML--- 182
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L +ATVTI H + +L + R+A+I++TA G P+ I ADM++PGA +IDVG
Sbjct: 183 ------LSANATVTIAH--SRSRELASITRSAEILVTAMGQPRRITADMIRPGAVVIDVG 234
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNT 289
I RI +GKS L GDVDYE +A ITPVPGGVGPMTVAML+HNT
Sbjct: 235 INRIQRPDGKSSLWGDVDYEAARAVASYITPVPGGVGPMTVAMLLHNT 282
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 254 bits (621), Expect = 3e-66
Identities = 139/298 (46%), Positives = 189/298 (63%), Gaps = 11/298 (3%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A++LDGKA+A +I++EL I Q R P + ++VGD+PAS YVRNK +A VG
Sbjct: 6 AKLLDGKAIAAKIQQELSVAITQLQPEIGRPPGLAVLMVGDNPASAAYVRNKEKACAKVG 65
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I + + ++ T +L I LN+D VDGILVQLP+PD ++ + I P+KD DG
Sbjct: 66 IASFGKHFPAETTFRELEKVIAALNDDERVDGILVQLPLPDHLDAVALLHQIDPDKDADG 125
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
H +N+GRL + T V+ +L+ + I G+ AVV+GRS VG P+A+ML
Sbjct: 126 LHPVNLGRLVRGEIGLRSCTPDGVMRLLQEYEIPLQGKQAVVVGRSILVGKPMALML--- 182
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L DATVTI H + L++ +NADI+I A G P LI ADMVKPGA ++DVG
Sbjct: 183 ------LEADATVTIAH--SRSHDLKSITQNADILIAAAGRPGLITADMVKPGAVVVDVG 234
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
+ R+TD +GKSRL+GDVD+E + +AG ITPVPGGVGPMTVA+L+ NTF + A K
Sbjct: 235 MNRVTDASGKSRLIGDVDFESTAGVAGFITPVPGGVGPMTVAILLQNTFTSYSRAAKK 292
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 252 bits (617), Expect = 8e-66
Identities = 135/296 (45%), Positives = 188/296 (63%), Gaps = 16/296 (5%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++DG AL+ ++ + ++ A + G+R P + I+VGD+PAS YVRNK++A + G
Sbjct: 3 ATLIDGNALSKTLRAQAAERAAALAARGHR-PGLAVILVGDNPASEVYVRNKIKACEDNG 61
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+L + ++E +LL+ I LN D + GILVQLP+P I+ +V +AIAPEKD+DG
Sbjct: 62 FFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDG 121
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+ N G L P P T V++M + + I G NAVVIGRS VG P+A++L
Sbjct: 122 FHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLL--- 178
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L ATVTICH T +L A+ R ADI++ A G ++ ADMVKPGAT+IDVG
Sbjct: 179 ------LEAGATVTICHSKT--RELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVG 230
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQA 297
+ R N + +L GDVD+ VS++AG ITPVPGGVGPMT+ ML+ NT +AA+ A
Sbjct: 231 MNR----NDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAA 282
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 251 bits (615), Expect = 1e-65
Identities = 134/297 (45%), Positives = 188/297 (63%), Gaps = 15/297 (5%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++DGKA+A +I+ E+ ++++ P + I+VGD S TYVRNK +A VG
Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKESIGVIPGLAVILVGDRKDSATYVRNKKKACDSVG 128
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I + + D +EE++L + N+D SV GILVQLP+P ++E+ + +A++ EKD+DG
Sbjct: 129 IKSFEVRLAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDG 188
Query: 122 FHIINIGRLCV--DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
FH +NIGRL + P VP T +E+L R+NI+ G+ AVVIGRS VGMP A++L
Sbjct: 189 FHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYNIEIKGKRAVVIGRSNIVGMPAALLLQ 248
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
+ DATV+I H T E R ADIII+A G P +++ +KPGA +ID
Sbjct: 249 RE---------DATVSIIHSRTKNP--EEITREADIIISAVGQPNMVRGSWIKPGAVLID 297
Query: 240 VGITRITDENGKS--RLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
VGI + D + RLVGD+ YEE SK+A AITPVPGGVGPMT+AML+ NT +A+
Sbjct: 298 VGINPVEDPSAARGYRLVGDICYEEASKVASAITPVPGGVGPMTIAMLLSNTLTSAK 354
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 250 bits (613), Expect = 3e-65
Identities = 126/293 (43%), Positives = 188/293 (64%), Gaps = 15/293 (5%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A+I+DGK +A ++K E+ ++ Q ++ G RAP + ++VGD+PAS YV +K + + VG
Sbjct: 3 AKIIDGKTIAQQVKDEVAARVTQRLAEGKRAPGLAVVLVGDNPASQIYVTSKRKVCEEVG 62
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+ + + TE +LL+ I LN D ++DGILVQLP+P+ I+ +V + IAP+KD+DG
Sbjct: 63 FISRSYDLPITTTESELLALIDQLNADQAIDGILVQLPLPEGIDNTKVIERIAPDKDVDG 122
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH N+GRLC P + T ++ +L+R+NIDTFG NAVV+G S VG P+++ L
Sbjct: 123 FHPYNVGRLCQRAPLLRACTPRGIITLLERYNIDTFGLNAVVVGASNIVGRPMSLEL--- 179
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L T T+ HR+T L + NAD+++ A G P I + +KPGA ++DVG
Sbjct: 180 ------LLAGCTTTVTHRFT--KNLRHHIENADLLVVAVGKPGFIPGEWIKPGAIVLDVG 231
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
I R+ E+GK +VGD+++E + A I+PVPGGVGPMTVA L+ NT QA +
Sbjct: 232 INRL--ESGK--VVGDIEFETAQERASYISPVPGGVGPMTVATLIQNTLQACE 280
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 248 bits (607), Expect = 1e-64
Identities = 133/295 (45%), Positives = 183/295 (62%), Gaps = 14/295 (4%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
+I+DGKA+A + +E+K ++ ++ + G P + ++VG+DPAS YVRNKV+ A FVGI
Sbjct: 12 KIIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGI 70
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 122
+L D+D++E++LL++I LN + V GILVQLP+P INE RV + I P+KD+DGF
Sbjct: 71 RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF 130
Query: 123 HIINIGRLCVDLPTIVPATALAVVEMLK-RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
H N+G L + P T + +LK D G +AVVIGRS VG P+A +L
Sbjct: 131 HSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGDDLSGLHAVVIGRSNIVGKPMAALL--- 187
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L TVT+ H T +E C+ ADI++ A G +I A +K A +IDVG
Sbjct: 188 ------LKESCTVTVVHSKT--RNIEQVCQQADIVVAAVGKANMINASYLKADAVVIDVG 239
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
I RI K+RLVGDVD+E+ + AITPVPGGVGPMT+A LM NT QA + Q
Sbjct: 240 INRIMTHE-KTRLVGDVDFEDALPMVSAITPVPGGVGPMTIAYLMKNTLQAVRLQ 293
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 248 bits (606), Expect = 2e-64
Identities = 134/297 (45%), Positives = 184/297 (61%), Gaps = 12/297 (4%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
MA I+ G A A + +L + +A++ + APT+ ++VGDDPASH YVR K+E + V
Sbjct: 1 MASIISGTAAAEGLLADLTRDVARFSQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRKV 60
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
G++++ +D +EE LL+ I +LN D V GILVQLP+P I+ +V D I P KD+D
Sbjct: 61 GMESVEHRLPADCSEEDLLALIASLNADERVHGILVQLPLPAQIDSGKVLDTIDPRKDVD 120
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
GFH +N+ RL +VP T + + +L+ D G+ AVVIG+S VG P+AM+L
Sbjct: 121 GFHPVNVFRLSTGTGGLVPCTPMGCMILLRSVLPDLKGKQAVVIGKSNIVGKPVAMLL-- 178
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
L TVT+C R+T L CRNADII+ A G P L+K VK GA +IDV
Sbjct: 179 -------LEQGCTVTVCGRHT--RNLAEVCRNADIIVAAAGTPHLVKGYWVKAGAVVIDV 229
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQA 297
GI RI ++G+SR+VGDV +E+ A A TPVPGGVGPMT+A L QAA+ +A
Sbjct: 230 GINRIALDDGRSRIVGDVASDEIGH-AAAFTPVPGGVGPMTIACLAAEYVQAARRRA 285
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 247 bits (605), Expect = 2e-64
Identities = 126/296 (42%), Positives = 188/296 (63%), Gaps = 15/296 (5%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
+LDG+ALA I+K+LK KI + ++ P + I+VG DPAS TYV K++A + VG+D
Sbjct: 8 LLDGQALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMD 67
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+ITE +LLS I++ N D ++ G+LVQLP+P I+ + + +AI P KD+DGFH
Sbjct: 68 FDLKTLQENITEAKLLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFH 127
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
+NIG+LC + +PAT + V+ +L+ ++I+ G++ +IG S +G P++M++
Sbjct: 128 PLNIGKLCTQKESFLPATPMGVMRLLEHYHIEIKGKDVAIIGASNIIGKPLSMLM----- 182
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
L A+V++CH T KD + Y +NADI+ G P LIKA M+K GA ++D+GI
Sbjct: 183 ----LNAGASVSVCHILT-KD-ISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGIN 236
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
+ D R+VGDVD+ V K+AG ITPVP GVGPMT+ L+ NT A + Q K
Sbjct: 237 HLND----GRIVGDVDFNNVQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRK 288
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 244 bits (597), Expect = 2e-63
Identities = 129/295 (43%), Positives = 187/295 (63%), Gaps = 9/295 (3%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
+LDGK A + E+ +K+A + G R P + I+VG+ S +YV++K+ + G +
Sbjct: 3 LLDGKKCAESLVAEIARKVAGYTESGLRTPHMTIILVGEHAPSESYVKSKIATSGLAGFE 62
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+ + I E +LL++I+ +NED + DG++VQLP+P IN++ V +AIAPEKDIDGFH
Sbjct: 63 STLLRFPETIRESELLAKIKEVNEDPTTDGLIVQLPLPKHINQQHVINAIAPEKDIDGFH 122
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
N GR+ + PATA + ++L+ + + ++ VVIGRS VG PI++ML +D
Sbjct: 123 PANFGRMTLGQKAFRPATAYGICKLLQFYEVPVKAKHCVVIGRSNIVGKPISIMLSND-- 180
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
+ G +ATVT+ H TP++ L R ADI+I A G+P + ADMVK G +IDVGI
Sbjct: 181 FDIG---NATVTLTHIETPRELLLDETRRADIVIVAVGIPGFVTADMVKDGVVLIDVGIN 237
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQAN 298
R+ E+GK +VGDVD+E V++ ITPVPGGVG MTVA LM NT A Q+ N
Sbjct: 238 RL--ESGK--IVGDVDFENVAQKCSWITPVPGGVGRMTVAALMINTLMAYQNNFN 288
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 242 bits (593), Expect = 7e-63
Identities = 131/297 (44%), Positives = 184/297 (61%), Gaps = 15/297 (5%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A+I+DGKA+A I+ E+ +++ + P + +IVG S TYV K +A VG
Sbjct: 9 AKIIDGKAIAHTIRSEIAEEVRGLSEKHGKVPGLAVVIVGSRKDSQTYVNTKRKACAEVG 68
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I + + +++E L+S++ LN + V GILVQLP+P INE + AI+ +KD+DG
Sbjct: 69 IKSFDVGLPEEVSEADLISKVHELNSNPDVHGILVQLPLPKHINEEHILGAISIDKDVDG 128
Query: 122 FHIINIGRLCVD--LPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
FH +NIG+L + P +P T +E+L R + G+ AVV+GRS VG+P++++L
Sbjct: 129 FHPLNIGKLAMKGREPLFLPCTPKGCLELLARSGVKIKGQRAVVVGRSNIVGLPVSLLL- 187
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
L DATVT H +T KD EA R ADI+I A G +IK + +KPGA +ID
Sbjct: 188 --------LKADATVTTVHSHT-KDP-EAIIREADIVIAACGQAHMIKGNWIKPGAAVID 237
Query: 240 VGITRITDENGKS--RLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
VG ++D + KS RLVGDVD+ E SK+AG ITPVPGGVGPMTVAML+ NT A+
Sbjct: 238 VGTNAVSDPSKKSGYRLVGDVDFAEASKVAGFITPVPGGVGPMTVAMLLRNTVDGAK 294
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 241 bits (589), Expect = 2e-62
Identities = 132/297 (44%), Positives = 186/297 (62%), Gaps = 9/297 (3%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
RI+DG+A+A +++ ++ + G P + +++ DDPAS TYV K + VGI
Sbjct: 13 RIIDGEAVAADVRDDVAAHVETLEEEGV-TPGLATVLMSDDPASETYVSMKQRDCEEVGI 71
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 122
+++ + D+D E+L I +LNE V GILVQLPVPD +++RRV IAP KD+DGF
Sbjct: 72 ESVHVEIDADAPAEELYETIDDLNEREDVHGILVQLPVPDHVDKRRVLRQIAPVKDVDGF 131
Query: 123 HIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
H N+GRL P T V ++L ++++T G +AVV+GRS VG P+A +L
Sbjct: 132 HPENVGRLVAGDARFKPCTPHGVQKLLAAYDVETEGADAVVVGRSDIVGKPMANLL---- 187
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
+ G +AT T+CH T +D LE ADI+I A G+P+ I M+K GAT+IDVGI
Sbjct: 188 -IQKGPIGNATTTVCHSRT-RD-LEGKLATADIVIAAVGVPEFIDGSMLKEGATVIDVGI 244
Query: 243 TRITDENGKS-RLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQAN 298
R+ + K LVGDV+YE + AGAITPVPGGVGPMT AML++NT +AA Q++
Sbjct: 245 NRVDADTEKGYALVGDVEYESAKEAAGAITPVPGGVGPMTRAMLLYNTVKAAGLQSD 301
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 241 bits (589), Expect = 2e-62
Identities = 136/313 (43%), Positives = 193/313 (61%), Gaps = 33/313 (10%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
+A ILDG ++ EIK E+ ++A+ + G P + ++VG +PAS YVRNKV+A +
Sbjct: 2 LATILDGNKISAEIKTEVAAEVAELKAKG-LTPGLAVVLVGHNPASEIYVRNKVKACEMT 60
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI + ++ LL +++LN N +DGILVQLP+P ++ +++ A++PEKD+D
Sbjct: 61 GIYSEQHTPPDTVSTADLLQLVESLNRRNDIDGILVQLPLPKQVDSKKILLAVSPEKDVD 120
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
GFH +N+G L P +VP T +E+L+R N+ G +AVV+GRS VG PIAM+L
Sbjct: 121 GFHPMNVGYLSTVRPGLVPCTPAGCMEILRRSNVPVEGADAVVVGRSDIVGKPIAMLL-- 178
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
+ATVTICH T L A CR ADI++ A G P +I D VKPGAT++DV
Sbjct: 179 -------TNANATVTICHSKT--HDLPAVCRRADILVAAIGRPGMITPDFVKPGATVLDV 229
Query: 241 GITRITD-------------------ENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMT 281
GI +ITD +NG S LVGD + +V+++AGA TPVPGGVGP+T
Sbjct: 230 GINKITDRAEFEKFFAGDAKREAAFAKNG-STLVGDC-HPKVAEVAGAFTPVPGGVGPLT 287
Query: 282 VAMLMHNTFQAAQ 294
+AMLM NT +AA+
Sbjct: 288 IAMLMANTVKAAK 300
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 239 bits (584), Expect = 8e-62
Identities = 131/297 (44%), Positives = 181/297 (60%), Gaps = 14/297 (4%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
ILDGK +A K+EL KI+++ + G R P + I+VG+DPAS YV +K++ A VGI
Sbjct: 3 ILDGKKVASRRKEELTAKISKYHNKGLRKPKLVVIMVGNDPASEVYVSHKIKVANEVGIY 62
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+ + D DI +E+L ++I LN D ++DGIL+QLP+P E AI P KD+DGFH
Sbjct: 63 SELLRFDKDIKKEELYNKINELNNDQNIDGILLQLPLPIDFIEEDYLQAITPSKDVDGFH 122
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
IN G++ T+ P T L ++ +L+ +NI ++ +IG S VG P+ MML
Sbjct: 123 YINQGKMLQGYDTVYPCTPLGIINLLEEYNISVKNKDITLIGTSNIVGKPLGMML----- 177
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
L AT+T+C++ T ++ + NADIII+ATG +I DM+K A IIDVGI
Sbjct: 178 ----LNNQATITMCNKNT--KNIKNHTINADIIISATGKQFIITEDMIKKDAVIIDVGII 231
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANKS 300
R N +LVGDVD+E+V + ITPVPGGVGPMTV LM NTF + NKS
Sbjct: 232 RDPVTN---KLVGDVDFEKVKLKSSYITPVPGGVGPMTVITLMENTFVLYEKHINKS 285
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 235 bits (576), Expect = 8e-61
Identities = 127/294 (43%), Positives = 181/294 (61%), Gaps = 16/294 (5%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
MA I+DGKA+A +I+ E+ + + G P + ++VGDD AS YV K +A
Sbjct: 1 MAHIIDGKAIAAKIRSEIASGVRELQGKGV-TPGLAVVLVGDDQASRVYVSMKEKACNDA 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI ++ ++ +E +LL+ ++ LN D + GILVQLP+P I+ +V +AI+P KD+D
Sbjct: 60 GIFSVEHKLAAETSEAELLALVELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVD 119
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
GFH N+GRL V P P T V+ ML+ ++ G+ VV+GRS VG P+AMM
Sbjct: 120 GFHPYNVGRLSVGKPVFQPCTPYGVMVMLREAGVELKGKEVVVVGRSNIVGKPVAMMC-- 177
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
L ATVT+CH T +D L R AD++I A G P++IK D +K GA +IDV
Sbjct: 178 -------LAEHATVTLCHSRT-RD-LPDVVRRADVVIAAVGRPEMIKGDWIKEGAVVIDV 228
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
GI R+ G+ +LVGDV++ S+ A AITPVPGGVGPMT+ ML+ NT ++A+
Sbjct: 229 GINRV----GEKKLVGDVEFAGASQRASAITPVPGGVGPMTITMLLQNTLESAK 278
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 235 bits (575), Expect = 1e-60
Identities = 125/299 (41%), Positives = 182/299 (60%), Gaps = 17/299 (5%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A+++DGKA A +++ ++ +++A + P + ++VG+DPAS YVRNK E G
Sbjct: 4 AKLIDGKAFAADLRAKIAEEVAALKAEHGVTPGLAVVLVGEDPASQVYVRNKGEQTTAAG 63
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+ + T T+++LL+ + LN D + G+LVQ PVP I++ V A++P+KD+DG
Sbjct: 64 MYSETHRLPETTTQDELLAVVAKLNADPKIHGVLVQFPVPPHISQMDVVAALSPDKDVDG 123
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
+ N GRL LP + P T + +++ D G+ AVVIGRS +G P+A ML
Sbjct: 124 LTVTNAGRLASGLPALAPCTPTGCMMLIRDAIGDLKGKTAVVIGRSNLMGKPMAQML--- 180
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L D TVTI H + L + R ADI++ A G +++KAD VKPGA +IDVG
Sbjct: 181 ------LAADCTVTIAH--SRSQDLPSIVRQADIVVAAVGRAEMVKADWVKPGAVVIDVG 232
Query: 242 ITRITDEN------GKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
ITR + GK+RLVGDV ++EV ++AGAITPVPGGVGPMT+A L+ NT AA+
Sbjct: 233 ITRFPARDPEAAAAGKTRLVGDVAFDEVREVAGAITPVPGGVGPMTIACLLANTLTAAK 291
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 234 bits (572), Expect = 2e-60
Identities = 129/302 (42%), Positives = 179/302 (59%), Gaps = 14/302 (4%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A I++GKA+A +I L I + P + ++VGDDPASH YVRNK A+ +G
Sbjct: 3 ANIINGKAIAEDITGTLATCINDLKLQYSLVPCLIVVLVGDDPASHLYVRNKQRKAEMLG 62
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+ + TI S +E L+ +I LN D++V GILVQLPVP I++ + + I P KD+DG
Sbjct: 63 LRSETILLPSTTSESSLIDKIHELNNDDNVHGILVQLPVPKHIDKNLIINTIDPRKDVDG 122
Query: 122 FHIINIGRLCVDLP--TIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
FH N+GRL ++P T + ++K + G +AVVIGRS VG P+A +L
Sbjct: 123 FHNDNVGRLFTGQKRNCLIPCTPRGCLYLIKTVTHNLSGSDAVVIGRSNIVGKPMACLL- 181
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
LG + TVT H T L YC ADI++ A G+P +K+ +KPGA +ID
Sbjct: 182 --------LGENCTVTTVHSAT--RNLSDYCSKADILVAAVGIPNFVKSSWIKPGAIVID 231
Query: 240 VGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
VGI + +E+G + VGDV++ E +A AITPVPGGVGPMT+A LM NT AA +Q+
Sbjct: 232 VGINSV-EEDGVKKFVGDVNFAEAKNVASAITPVPGGVGPMTIAFLMVNTVMAACNQSGI 290
Query: 300 SN 301
N
Sbjct: 291 EN 292
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 233 bits (571), Expect = 3e-60
Identities = 126/288 (43%), Positives = 185/288 (64%), Gaps = 16/288 (5%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
++DGK +A E++++L+Q++ + + N+ P + I++G+ S YVR K +AA VG+
Sbjct: 3 LIDGKKIAAELREQLRQEVVELKAKHNKIPGLTVILIGEMAPSQIYVRMKEKAANEVGLK 62
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+ I + E+ +L +I+ LN+D S+ GILVQLP+P I++++V + I P KD+DGFH
Sbjct: 63 SEVIRYPEAVEEKTVLDKIEELNKDESISGILVQLPLPKHIDKQKVIETILPGKDVDGFH 122
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
+N+G L + VP T L M+K+ + G+ AV+IGRS G P+A +L
Sbjct: 123 PMNVGNLSSGYESSVPCTPLGCYLMIKKIEPNLSGKKAVMIGRSNLNGKPMAQLL----- 177
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
L + TVTI H T KD L+A C ADII+ A G+P+L+KAD VK A +IDVGI
Sbjct: 178 ----LKENCTVTITHSKT-KD-LKAECLEADIIVAAVGIPELVKADWVKKDAIVIDVGIN 231
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQ 291
+ ENG +VGDV +EEVSK+A A+TPVPGGVGPMT+A L+ NT +
Sbjct: 232 K--TENG---IVGDVAFEEVSKVARALTPVPGGVGPMTIACLLKNTIE 274
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 231 bits (565), Expect = 2e-59
Identities = 128/298 (42%), Positives = 171/298 (57%), Gaps = 11/298 (3%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
AR++DGK A E L ++ + AP + ++VGDDPAS TYV K A
Sbjct: 3 ARLIDGKQAAHECTARLATRVQALRAAVGTAPFLAAVLVGDDPASCTYVAAKQRALARAH 62
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+ T + + Q+L I LNED V GIL+QLP+P ++ RVC A+APEKD+DG
Sbjct: 63 LRGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAHLDAARVCRAVAPEKDVDG 122
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH +N G L + P VP T +V +L+R + G V++GRS VG P+A++L S
Sbjct: 123 FHPLNCGALFLAQPGFVPCTPAGIVHLLRRAQVPLAGARVVIVGRSAIVGRPLAVLLASP 182
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
G DATVT+CH +T L C ADI++ A G + I A V+ GA +IDVG
Sbjct: 183 -------GCDATVTLCHSHT--RGLADICVQADILVAALGKARFIGAPFVRTGAVVIDVG 233
Query: 242 ITRITDENGK--SRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQA 297
I + D RL GDVD++ V+ AITPVPGGVGPMT+AML+HNT AA+ A
Sbjct: 234 IHHVPDATAPRGRRLCGDVDFDAVAHKVQAITPVPGGVGPMTIAMLLHNTLCAAEYAA 291
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 230 bits (562), Expect = 4e-59
Identities = 130/302 (43%), Positives = 181/302 (59%), Gaps = 17/302 (5%)
Query: 4 ILDGKALAMEIKKELKQKIAQ-WVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
+L G LA EI++ L + +A L N AP + + VG S+ Y+R K++AA +GI
Sbjct: 9 VLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGI 68
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDT--INERRVCDAIAPEKDID 120
A + + TE +LL+++ LN D GI+VQ+P+ IN + D ++P+KD+D
Sbjct: 69 KATHVKMPNTTTEHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDVD 128
Query: 121 GFHIINIGRLCV-DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
G + IN GR+ + D+ +P T +E++KR + G AVV+GRSK VG P+A +L
Sbjct: 129 GLNTINEGRVAIGDMSGFLPCTPNGCIELIKRSGVPIAGAQAVVLGRSKIVGTPVAELL- 187
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
K H +ATVT+CH T KD L + ADI++ G P+L+K +KPGA +ID
Sbjct: 188 --KWH------NATVTVCHSRT-KD-LPSVVSKADIVVVGIGQPELVKGSWIKPGAVVID 237
Query: 240 VGITRITDENGKS--RLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQA 297
GI I D KS RLVGDVDY E +K+A ITPVPGGVGPMTVAMLM NT +AQ A
Sbjct: 238 CGINSIPDPTKKSGQRLVGDVDYAEAAKVASYITPVPGGVGPMTVAMLMKNTVISAQRAA 297
Query: 298 NK 299
+
Sbjct: 298 ER 299
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 230 bits (562), Expect = 4e-59
Identities = 124/301 (41%), Positives = 180/301 (59%), Gaps = 13/301 (4%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M I+DGK +A + L+ + + + P + +IVGDDPAS YV NK A+ +
Sbjct: 1 MREIIDGKLVARGLLDRLRVSVDRLKAEHGIVPHLVVVIVGDDPASKLYVGNKQRKAEEL 60
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
G+ + TI + D ++E+LL I LN D +V GILVQLP+P I++ V +AI+PEKD+D
Sbjct: 61 GLQSRTIALEHDTSQEELLRIIDELNRDAAVHGILVQLPLPRHIDKELVINAISPEKDVD 120
Query: 121 GFHIINIGRLCV-DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
GFH N G+L L ++P T + ++K D G NAVV+GRS VG P+A++L
Sbjct: 121 GFHNANAGKLATGQLDCMIPCTPQGCIHLIKTVKQDLAGSNAVVVGRSNIVGKPVALLL- 179
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
L + TVT+ H + LE +C ADII+ A G + I+A +KPGA ++D
Sbjct: 180 --------LYENCTVTVLH--SASRNLEEHCLRADIIVAAVGKARFIRASWIKPGAIVVD 229
Query: 240 VGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
VGI + +E+GK R VGDV++E + + ++TPVPGGVGPMT+A L+ NT + Q
Sbjct: 230 VGI-NLVEESGKKRFVGDVEFEGLQDVPCSVTPVPGGVGPMTIAFLLVNTVLGSCKQCGV 288
Query: 300 S 300
S
Sbjct: 289 S 289
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 229 bits (561), Expect = 5e-59
Identities = 128/296 (43%), Positives = 180/296 (60%), Gaps = 19/296 (6%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
+RI+DGK LA ++++E++ + S P + I+VGDDPAS YVR K A + VG
Sbjct: 8 SRIIDGKVLAQQVEEEVRSGVEDLESNRGIVPGLATILVGDDPASKMYVRLKHRACERVG 67
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTIN---ERRVCDAIAPEKD 118
I A D T+E+LL+ I +LN++ V IL+QLP+P + + +AI+P KD
Sbjct: 68 IKAEDYLLPGDATQEELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAMEAISPTKD 127
Query: 119 IDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMML 178
DGFH N+G+L + +VP T V+ L+ + + G+NAV++G S VG P+A ML
Sbjct: 128 ADGFHPYNMGKLMIGDEDLVPCTPHGVIRALEEYGVSVQGKNAVIVGHSNVVGKPMAAML 187
Query: 179 HSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATII 238
L +ATV++CH +T D L+ Y ADII+ ATG+ LIKADMVK G I
Sbjct: 188 ---------LNRNATVSVCHIFT--DDLKKYTLGADIIVVATGVKHLIKADMVKEGTVIF 236
Query: 239 DVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
D GIT+ +E+G + GDVD+E V K A +TPVPGGVGPMT+AMLM + A+
Sbjct: 237 DAGITK--EEDG---VYGDVDFENVIKKASLVTPVPGGVGPMTIAMLMKHVLLCAE 287
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 227 bits (554), Expect = 4e-58
Identities = 119/293 (40%), Positives = 176/293 (60%), Gaps = 15/293 (5%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A+ +DG ++ ++ E+ ++ V G RAP + ++VG+DPAS YV +K A + VG
Sbjct: 3 AQNIDGTLISQTVRSEVAARVKARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEVG 62
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+ + + + +EE LLS ++ LN D +DGILVQLP+P ++ +V ++I PEKD+DG
Sbjct: 63 FVSKSFDLPATASEEALLSLVEELNNDPQIDGILVQLPLPAGMDTTKVLESIHPEKDVDG 122
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH N+GRL +P + T ++ +L+R+NI G++AV++G S VG P+ + L
Sbjct: 123 FHPYNVGRLAQRIPKLRSCTPKGIITLLERYNIPLRGKHAVIVGASNIVGRPMTLEL--- 179
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L T T CHR+T LE + R ADI++ A G P I +K GA ++DVG
Sbjct: 180 ------LLAGCTTTTCHRFT--QDLEGHIRQADILVVAVGKPNFIPGAWIKEGAVVVDVG 231
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
I R+ + GK LVGDV+Y+ A ITPVPGGVGPMTVA L+ NT A +
Sbjct: 232 INRL--DTGK--LVGDVEYDVARTRASFITPVPGGVGPMTVASLIENTMMACE 280
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 225 bits (550), Expect = 1e-57
Identities = 116/296 (39%), Positives = 181/296 (61%), Gaps = 17/296 (5%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
MA++LDGK ++ +K+E+K+++ +W G P + ++VGDDPAS Y ++K + + +
Sbjct: 1 MAQLLDGKEISKVLKEEIKEEVKRWKEQGVN-PKLAVVLVGDDPASVVYAKSKQKVSDSL 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GID +D +EE +L+ I +LN + V GI+++LP+P I++ RV A+ P+KD+D
Sbjct: 60 GIDFELTVLPADSSEESILALIDSLNANPDVHGIMIELPLPKHISKERVMAAVRPDKDVD 119
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
G H IN G + + PAT + +E++ R ++ G++ V++GR + VG P+ ++
Sbjct: 120 GVHPINRGYILSGEEGLFPATPESCIEIMLRSGVEIAGKHVVIVGRGETVGKPLVFLI-- 177
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
L +ATVTICH TP L A+ R ADII+ A G KL+K DMVKPGA ++D
Sbjct: 178 -------LKHNATVTICHSRTP--DLGAFTRQADIIVAAVGKAKLVKKDMVKPGAIVVDA 228
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
GI I + GDVD+EEV ++A I+PVPGGVG +T A++M N + Q
Sbjct: 229 GINEI-----PGGICGDVDFEEVKEVASLISPVPGGVGSLTTALIMKNVLKGITLQ 279
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 225 bits (549), Expect = 1e-57
Identities = 123/294 (41%), Positives = 180/294 (61%), Gaps = 16/294 (5%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
MA +L+GK L+ E+K+++K ++ + G P + I+VGD+PAS +YV+ K +A
Sbjct: 1 MATLLNGKELSEELKQKMKIEVDELKEKG-LTPHLTVILVGDNPASKSYVKGKEKACAVT 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI + I +I++++LL I N D+SV GILVQLP+PD ++E+++ AI+P KD+D
Sbjct: 60 GISSNLIELPENISQDELLQIIDEQNNDDSVHGILVQLPLPDQMDEQKIIHAISPAKDVD 119
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
GFH IN+G++ T +P T ++ ML+ +I G++AV+IGRS VG PI ++L
Sbjct: 120 GFHPINVGKMMTGEDTFIPCTPYGILTMLRSKDISLEGKHAVIIGRSNIVGKPIGLLL-- 177
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
L +ATVT H T L+ + ADI+I A G I AD +K A +IDV
Sbjct: 178 -------LQENATVTYTHSRT--KNLQEITKQADILIVAIGRAHAINADYIKEDAVVIDV 228
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
GI R D +L GDVD+E + A ITPVP GVGPMT+ ML+ NT +AA+
Sbjct: 229 GINRKDD----GKLTGDVDFESAEQKASYITPVPRGVGPMTITMLLKNTIKAAK 278
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 222 bits (542), Expect = 1e-56
Identities = 121/297 (40%), Positives = 168/297 (56%), Gaps = 9/297 (3%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M I+DG A+A +++ +L + + G P + +++ D AS TYV K + + V
Sbjct: 1 MTEIIDGDAVAAQLRADLTGAVETLETAGV-TPRLATVLMNDKQASETYVSMKQQDCEEV 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI A + D + + + L + LN V GILVQ P PD + + RV A+ P KD+D
Sbjct: 60 GIAAEDVRIDPEASADTLFDTVAELNAREDVHGILVQDPTPDHVPDERVLSAVDPAKDVD 119
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
GFH N+G+L P P T V ++L +D G VV+GRS VG P+A +L
Sbjct: 120 GFHPENVGKLVGGTPRFKPCTPHGVQKLLAHQGVDPDGAEVVVVGRSNIVGKPLANLL-- 177
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
+ G +ATVTICH +T D L A+ R AD+++ A G+P+LI DM+ +IDV
Sbjct: 178 ---AQKAAGGNATVTICHSHT--DDLAAHTRRADVVVAACGVPELIDGDMLSGDPVVIDV 232
Query: 241 GITRITDENGKS-RLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
GI R+ + K LVGDVDY+ A AITPVPGGVGPMT AML++NT AA Q
Sbjct: 233 GINRVDADTEKGYELVGDVDYDSAEAAASAITPVPGGVGPMTRAMLLYNTLAAASEQ 289
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 220 bits (537), Expect = 4e-56
Identities = 117/290 (40%), Positives = 177/290 (61%), Gaps = 16/290 (5%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
I+DGKALA EI +LK +I + +P + ++VGD+PAS YV+NK++ A VGID
Sbjct: 5 IIDGKALANEILADLKLEIQGFKEKTKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGID 64
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
L +N ++I + L+ +I LN D + GI+VQLP+P +I+E ++ A+ P KD DGFH
Sbjct: 65 TLLVNLSTNIYTDDLILKINELNLDKGISGIIVQLPLPSSIDENKILSAVLPSKDSDGFH 124
Query: 124 IINIGRLCVDL-PTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
+N+G L + +P TAL + ++K++ + G++AV++GRS VG P++ +L
Sbjct: 125 PLNVGYLHSGINQGFIPCTALGCLAVIKKYAPNLNGKDAVIVGRSNIVGKPLSALL---- 180
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
L + +VTICH T L + ADI++ A G P + A+ P A +IDVGI
Sbjct: 181 -----LQENCSVTICHSKT--CNLSSITSKADIVVVAIGSPLKLTAEYFNPEAIVIDVGI 233
Query: 243 TRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
RI+ +++ GDVD+E V ITPVPGG+GPMT+A L+ NT +A
Sbjct: 234 NRIS----HNKIAGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKA 279
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 219 bits (536), Expect = 5e-56
Identities = 123/296 (41%), Positives = 175/296 (59%), Gaps = 16/296 (5%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ILDGKALA +I+++L ++ + R P++ I+VGDDPAS TYVR K A + VG
Sbjct: 14 ATILDGKALAKQIEQQLSTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACQRVG 73
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+D++ + S T +L+++I LN + V GIL+Q PVP I+ER + I KD+DG
Sbjct: 74 MDSIRVEMPSATTTAELMAKIDELNNNPDVHGILLQHPVPAHIDERACFEQIDLAKDVDG 133
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
+ GR+ + T ++ +L+ NI+ G AVV+GRS +G P+AMML
Sbjct: 134 VTCLGFGRMAMQQSAYGSCTPQGIMHLLEHHNIELAGLEAVVVGRSAILGKPMAMML--- 190
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L + TVTICH T LE++ + ADI++ A G+P+LIKA+ +K GA +ID G
Sbjct: 191 ------LNANCTVTICHSRT--QDLESHIKRADIVVGAVGVPELIKANWIKAGAVVIDAG 242
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQA 297
TD G VGD++ + V IA A TPVPGGVGPMT+ L+ T AA+ A
Sbjct: 243 F-HPTDNGG----VGDIELQGVENIASAYTPVPGGVGPMTINTLIRQTVDAAEKSA 293
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 218 bits (533), Expect = 1e-55
Identities = 100/200 (50%), Positives = 144/200 (72%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G LA +I++E+++ + + V+ GN P + ++VG+DPAS TYV+NK AA +G
Sbjct: 7 AVVISGTELARQIQREIQRDVEELVAQGNMRPHLGVVLVGEDPASRTYVKNKTRAASILG 66
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I + T+ R S +++E+LL I +N D V G+LVQLP+P+ INER VC+AIAPEKD+DG
Sbjct: 67 ISSDTVVRPSSVSQEELLELIDKMNRDWRVSGLLVQLPLPEHINERAVCNAIAPEKDVDG 126
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FHI+NIG+LC+D ++VPAT AV E++KR I+T G+N +V GRSKNVGMPIAM+LH+D
Sbjct: 127 FHIVNIGKLCLDQRSMVPATPAAVWEIIKRAGIETVGKNVLVAGRSKNVGMPIAMLLHTD 186
Query: 182 KRHESGLGMDATVTICHRYT 201
++HE G T +T
Sbjct: 187 RKHERSGGRHHTQARARAHT 206
Score = 133 bits (321), Expect = 6e-30
Identities = 68/106 (64%), Positives = 80/106 (75%), Gaps = 1/106 (0%)
Query: 191 DATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITRITD-EN 249
DATVTI HR TPK +L+ R ADII+ A G+P LI ADMVK GA +IDVGI RI D +
Sbjct: 295 DATVTIAHRCTPKAQLKELTRLADIIVAAAGVPGLITADMVKEGAAVIDVGINRIQDPKT 354
Query: 250 GKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQS 295
GK RLVGDVD++ V + A ITPVPGGVGPMTV+MLM NT AA++
Sbjct: 355 GKVRLVGDVDFDGVKEKAAFITPVPGGVGPMTVSMLMKNTVAAARN 400
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 218 bits (532), Expect = 2e-55
Identities = 120/293 (40%), Positives = 180/293 (61%), Gaps = 15/293 (5%)
Query: 5 LDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 64
LDGKA EI +LK+++A G R P + ++VGDDP S YVR K VGI++
Sbjct: 9 LDGKATRDEIFVDLKERVAALTEQG-RTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGINS 67
Query: 65 LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHI 124
+ + +DI++ +L + I LN + G +VQLP+P ++E + I P KD DG H
Sbjct: 68 IRRDLPADISQAELDATIDELNANPECTGYIVQLPLPKHLDENAALERIDPGKDADGLHP 127
Query: 125 INIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRH 184
N+GRL ++ P +P T +V +L+R+ ++ G + VVIGR VG P+ ++L +R
Sbjct: 128 TNLGRLVLNEPAPLPCTPRGIVHLLRRYEVEIAGAHVVVIGRGVTVGRPLGLLL--TRRS 185
Query: 185 ESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITR 244
E +ATVT+CH T L + R ADII+ A G+P ++ A+MV+PGA +IDVG++R
Sbjct: 186 E-----NATVTLCH--TATRHLPQFTREADIIVAAAGVPHMVTAEMVRPGAAVIDVGVSR 238
Query: 245 ITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQA 297
D+NGK LVGDV +V ++AG ++P PGGVGP+T A L+ N + A++ A
Sbjct: 239 --DDNGK--LVGDV-APDVWEVAGHVSPNPGGVGPLTRAFLLTNVVERAEALA 286
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 217 bits (531), Expect = 2e-55
Identities = 126/292 (43%), Positives = 178/292 (60%), Gaps = 21/292 (7%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A++L G A + +E++ ++ SL + P++R I +G+DPAS YVR K + A+ +G
Sbjct: 3 AQVLSGHEAAEAVYEEIRARLR---SL-SFTPSLRVIRLGEDPASVAYVRLKDKRARALG 58
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+ D+ EE LL I LN D VDGILVQLP+P I +RV +AI P KD+DG
Sbjct: 59 YRSQVEVYPEDLPEEALLERIAALNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDG 118
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH +N+GRL + P T L VV +LK + +D G+ VV+GRS VG P+A +L
Sbjct: 119 FHPLNVGRLWSGGKGLFPCTPLGVVRLLKHYGVDLRGKEVVVVGRSNIVGKPLAGLL--- 175
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L DATVT+ H T L R A +++ A G P L++ + V+ GA ++DVG
Sbjct: 176 ------LREDATVTLAHSKT--QDLPEVTRRAQVLVVAVGRPHLVRKEWVREGAIVVDVG 227
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAA 293
+ R+ + RL+GDV + EV+++A A+TPVPGGVGPMTVAMLM NT +AA
Sbjct: 228 VNRV-----EGRLLGDV-HPEVAEVAFALTPVPGGVGPMTVAMLMGNTLEAA 273
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 217 bits (529), Expect = 4e-55
Identities = 131/292 (44%), Positives = 173/292 (59%), Gaps = 15/292 (5%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
MA LDGKALA ++ L+ +I + R P + + VGDDPAS YV NK +A +
Sbjct: 1 MALRLDGKALAKAVESRLQAQIESNLPQAGRPPGLAVLRVGDDPASAVYVANKEKACARI 60
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
G+ + + S ++LS IQ LN D VDGIL+QLP+P+ ++E + AI PEKD D
Sbjct: 61 GVASYGAHLPSSTPFAEVLSTIQQLNADPRVDGILLQLPLPEGLDEGPLLMAIDPEKDAD 120
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
G H +N+GRL T V+ ML+ ID G+ AVVIGRS VG P+A+ML +
Sbjct: 121 GLHTLNLGRLLKGEQGPRSCTPAGVMAMLRSQGIDPAGQRAVVIGRSILVGQPMALMLQA 180
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
+ATVT+ H T KD L A+ R ADI++ A G P ++ A+ +KPGA ++DV
Sbjct: 181 ---------ANATVTVVHSRT-KD-LVAHTREADIVVVAAGRPGMVGAEHIKPGAAVVDV 229
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
GI R E G L GDV EV IA A++PVPGGVGPMTV ML+ NT A
Sbjct: 230 GIHR-KPEGG---LCGDVRAAEVEPIAAALSPVPGGVGPMTVTMLLVNTVVA 277
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 216 bits (528), Expect = 5e-55
Identities = 125/302 (41%), Positives = 177/302 (58%), Gaps = 12/302 (3%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M+ LDGK L++EI++ L+ I ++ R P + I +G+DPAS YV NK +A V
Sbjct: 1 MSLKLDGKKLSLEIEERLRNYILTNKTIAKRNPGLAVIRIGEDPASGVYVGNKEKACSRV 60
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI + + + ++++ + LN DN++DG+L+QLP+ +E+R+ I PEKD+D
Sbjct: 61 GIKSYIFHLKDTVEQKEVEQLLNKLNLDNNIDGMLLQLPISKKFDEQRLISFINPEKDVD 120
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
G + NIG+L + + T +V +LK NI G+ VVIGRS VG P+++M+
Sbjct: 121 GLNEQNIGKLVKNEQAMRSCTPAGIVNLLKSQNIKIEGKKIVVIGRSLLVGKPLSLMM-- 178
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
L ++ATVTI H T L C+ ADI+I A G P LI + VK GA IIDV
Sbjct: 179 -------LNLNATVTITHSKT--INLNKICKEADILIAAAGKPNLINSSFVKEGAVIIDV 229
Query: 241 GITRIT-DENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
GI R+T + K+RL GDV E+V A TPVPGGVGPMTV ML+ NT + Q Q
Sbjct: 230 GIHRLTSSDKSKTRLCGDVLLEDVIPKVFAYTPVPGGVGPMTVTMLLVNTIFSWQKQFGL 289
Query: 300 SN 301
S+
Sbjct: 290 SS 291
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 215 bits (525), Expect = 1e-54
Identities = 124/286 (43%), Positives = 174/286 (60%), Gaps = 17/286 (5%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
MA ILDGKA+A K ++K K+ ++ N + ++VG+D AS Y V+ A +
Sbjct: 1 MALILDGKAVAAAYKAKIKAKVDA-LAAQNITCGLAILLVGNDAASRIYADRLVKLATGL 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
G+ A+ + +D TEE++L+ + LNED+ + GIL +P+P + RV A+AP+KD+D
Sbjct: 60 GVQAVVRHLPADATEEEVLALVCELNEDDHIHGILPMMPLPPHLATDRVAAALAPDKDVD 119
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
H +N G + P T AV+ +L + ID G++AVVIGRS VG P+A +L
Sbjct: 120 ALHPLNAGLVATGKSRWAPCTPRAVMAILDYYQIDVSGKHAVVIGRSNVVGKPLAHLL-- 177
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
LG +ATVT+CH T +D L A R AD+I+ A G P LI DMV+PGA +IDV
Sbjct: 178 -------LGQNATVTVCHSKT-RD-LAALTRQADVIVAAVGRPALIGPDMVRPGAVVIDV 228
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLM 286
GI + NG +VGDVDY+ V IAGAITPVPGGVG +T M++
Sbjct: 229 GINEV---NG--AVVGDVDYDAVFPIAGAITPVPGGVGAVTTVMVV 269
>UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Fusobacterium nucleatum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Fusobacterium nucleatum subsp. nucleatum
Length = 283
Score = 214 bits (523), Expect = 2e-54
Identities = 123/290 (42%), Positives = 176/290 (60%), Gaps = 17/290 (5%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
++DGK LA +IK ++K +I + N P + I+VGDDPAS Y+ ++V++ + +GI
Sbjct: 2 LMDGKELARDIKVKIKAEIDNIKKIHNINPMVATILVGDDPASQVYLNSQVKSYQDLGIG 61
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+I+E LL+ I LN+D VDGI++ LP+P IN +V ++I KD+DGF
Sbjct: 62 VQKYFFSEEISEAYLLNLIDKLNKDTEVDGIMINLPLPPQINATKVLNSIKLIKDVDGFK 121
Query: 124 IINIGRLCVDLPTIV-PATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
N+G L + P+T ++ +++++NID G++ VV+G S VG PIA ++
Sbjct: 122 AENLGLLFQNNEGFTSPSTPAGIMALIEKYNIDLEGKDVVVVGSSNIVGKPIAALI---- 177
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
L TVTIC+ YT L +NADI+I+A G KLI DMVK GA +IDVGI
Sbjct: 178 -----LNSRGTVTICNIYT--KNLAEKTKNADILISAVGKAKLITEDMVKEGAVVIDVGI 230
Query: 243 TRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
R+ NGK L GDVD+E V K A ITPVPGGVG +TVAML+ N ++
Sbjct: 231 NRV---NGK--LEGDVDFENVQKKASHITPVPGGVGALTVAMLLSNILKS 275
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 212 bits (517), Expect = 1e-53
Identities = 126/296 (42%), Positives = 172/296 (58%), Gaps = 17/296 (5%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M +ILDGK +A + ++LK+K+ G P I +GDDPAS YVR K A+ +
Sbjct: 1 MGKILDGKFVANLLGEKLKEKVKDLKEEGI-TPHFCVINIGDDPASKIYVRTKKRRAEKM 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI +D +E L+ I LNED ++G++VQLP P+ I+ + + I P KD+D
Sbjct: 60 GIIQDIYQLPADTKQEVALNLIDKLNEDPDINGVMVQLPAPEQIDADELLERIDPNKDVD 119
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
G NIGR+ ++ I PATA ++ +LK + I G+N VVIGRS VG P+A ++
Sbjct: 120 GLTPSNIGRIWMENHFIEPATAEGIIALLKYYKILLKGKNVVVIGRSNIVGKPVAALM-- 177
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
L +ATVTI H T + L RNADII++ATG L+ DMVK G ++DV
Sbjct: 178 -------LEQNATVTIAHSET--ENLAELTRNADIIVSATGQAFLVTEDMVKDGVVVVDV 228
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
G+ + NGK LVGDVD+E V K A ITPVPGGVGP+TV LM + + Q
Sbjct: 229 GMNHV---NGK--LVGDVDFENVKKKASYITPVPGGVGPLTVQFLMEAVVKLTRRQ 279
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 211 bits (515), Expect = 2e-53
Identities = 124/301 (41%), Positives = 182/301 (60%), Gaps = 20/301 (6%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVS-LGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
A IL+GK ++ +I+ LK ++ Q + P + + VG+ S+ Y+ K++AA+ +
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVP--DTINERRVCDAIAPEKD 118
GI A I TE +++ I +LNED++V G LVQLP+ ++IN V +AIAPEKD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 119 IDGFHIINIGRLCV-DL-PTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAM 176
+DG IN GRL DL +P T +E++K + GR+AVV+GRSK VG P+
Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPM-- 181
Query: 177 MLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGAT 236
H+ L +ATVT CH T L+ DI++ ATG P+++K + +KPGA
Sbjct: 182 -------HDLLLWNNATVTTCHSKTAH--LDEEVNKGDILVVATGQPEMVKGEWIKPGAI 232
Query: 237 IIDVGITRITDE---NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAA 293
+ID GI + D+ NG+ ++VGDV Y+E + A ITPVPGGVGPMTVAMLM +T ++A
Sbjct: 233 VIDCGINYVPDDKKPNGR-KVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESA 291
Query: 294 Q 294
+
Sbjct: 292 K 292
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 210 bits (513), Expect = 3e-53
Identities = 116/297 (39%), Positives = 171/297 (57%), Gaps = 14/297 (4%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M ILDGK +A E++ L ++A++ RAP + +IVGDD ASH YV+NK A + +
Sbjct: 1 MVLILDGKEVAKEVRASLVPRVAKFKETYGRAPQLSVVIVGDDKASHVYVKNKKIACEKI 60
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
G+ + ++ T+ +L + LN DN VDGILVQ P+P ++ V ++ EKD D
Sbjct: 61 GMTSTIHTLPAETTQSELNQILSKLNNDNGVDGILVQFPLPKHLSSDEVLKLVSAEKDAD 120
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
G ++G P + P T V+E+LK + I G+ AVV+GRS VG P+A++L
Sbjct: 121 GLTYESLGYFFAGKPLVSPCTPAGVMEILKHYRIPVEGKKAVVVGRSNIVGKPMALLLTE 180
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
+ATVT+CH T + + AD+++ A G +L+ + K A +IDV
Sbjct: 181 ---------ANATVTLCHSKT--SNMSELTKQADLVVVAAGKARLLGKEDFKKDAIVIDV 229
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQA 297
G+ + + GK L GDV +EE+ A A TPVPGGVGPMT+AML+ NT Q A+ +A
Sbjct: 230 GM-HGSGQGGK--LCGDVRFEELDGWAKAATPVPGGVGPMTIAMLLKNTCQLAEQRA 283
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 208 bits (509), Expect = 1e-52
Identities = 119/295 (40%), Positives = 168/295 (56%), Gaps = 15/295 (5%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ILDG+ALA +++EL+ ++ AP++ + + DPAS Y R + + +G
Sbjct: 3 AIILDGRALAKTLREELRADTQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEEIG 62
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I + T+ L I L+ D ++ GIL+ LP+P ++ R I P KD+DG
Sbjct: 63 ITFTDHTLPPETTQAMLEETISALSFDRTIHGILLHLPLPPGLDSARAIAQIDPAKDVDG 122
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
H N G L + P ++P T +E+L R NI G++A V+GRS VG P+A++L
Sbjct: 123 VHPYNAGLLAMGRPGLIPNTPAGGMELLLRNNIPLKGQHATVVGRSVVVGKPMALLL--- 179
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
L ATVTI H T KD L A R+ADI++ ATG P LI DMVKPGA ++D G
Sbjct: 180 ------LNEHATVTIAHSRT-KD-LAAVVRSADIVVAATGKPGLITGDMVKPGAVVVDFG 231
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
+ + D R+VGDVD++ V +A AITPVPGG GP+T ML+ N +AAQ Q
Sbjct: 232 VNVLED----GRVVGDVDFDSVVNVASAITPVPGGTGPVTNVMLLRNVLRAAQQQ 282
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 208 bits (508), Expect = 1e-52
Identities = 124/291 (42%), Positives = 171/291 (58%), Gaps = 19/291 (6%)
Query: 5 LDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 64
+DGK ++ +K +K+ + + + G P + ++VGD+PAS TYVRNK A + VGI
Sbjct: 6 IDGKVISQSVKDRVKKAVEELKNQGIN-PCLATVLVGDNPASATYVRNKHRACEEVGITT 64
Query: 65 LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHI 124
D+ T+ QL I+NLN DNSV GILVQLP+P+ ++E I+P KD+DG
Sbjct: 65 KDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQLDEFTTTSRISPLKDVDGLTP 124
Query: 125 INIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRH 184
N G L + +V T V+EM I+ G+N V+I RS VG P+ +L
Sbjct: 125 HNAGLLAMKKAALVACTPSGVMEMFDYHGIELEGKNIVLINRSNLVGKPLYHLL------ 178
Query: 185 ESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPK--LIKADMVKPGATIIDVGI 242
L +ATV CH T K+ +E C++ADIIITA G + +DM+K GA +IDV I
Sbjct: 179 ---LDKNATVITCHSRT-KNLVE-LCQSADIIITAVGDRNKFTLTSDMIKEGAIVIDVAI 233
Query: 243 TRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAA 293
+R + +LVGD DYE++ + A TPVPGGVGPMTVAML+ NT AA
Sbjct: 234 SRF-----QEKLVGDADYEDIIQKASFATPVPGGVGPMTVAMLLKNTITAA 279
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 208 bits (507), Expect = 2e-52
Identities = 117/282 (41%), Positives = 170/282 (60%), Gaps = 16/282 (5%)
Query: 18 LKQKIAQW-VSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEE 76
L+ + W +L R+ + IV D A +R+ ++ +++ + D +EE
Sbjct: 34 LRTTASTWRCTLSIRSSSSPSAIVIDGKAEAKKIRDDIKIEVSRMKESIGVVPAEDSSEE 93
Query: 77 QLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DL 134
++L + N+D SV G+LVQLP+P ++E+ + +A++ EKD+DGFH +NIGRL +
Sbjct: 94 EVLKYVSGFNDDPSVHGVLVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGRE 153
Query: 135 PTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATV 194
P VP T +E+L R+NI+ G+ AVVIGRS VGMP A++L + DATV
Sbjct: 154 PLFVPCTPKGCIELLHRYNIEFKGKRAVVIGRSNIVGMPAALLLQKE---------DATV 204
Query: 195 TICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITRITDEN--GKS 252
+I H T E R ADI+I+A G P +++ +KPGA +IDVGI + D + G
Sbjct: 205 SIIHSRTMNP--EELTRQADILISAVGKPNMVRGSWIKPGAVLIDVGIKPVEDPSAAGGE 262
Query: 253 RLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
RLVGD+ Y E SKIA AITPVPG VGPMT+AML+ NT +A+
Sbjct: 263 RLVGDICYVEASKIASAITPVPGDVGPMTIAMLLSNTLTSAK 304
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 207 bits (505), Expect = 3e-52
Identities = 122/295 (41%), Positives = 166/295 (56%), Gaps = 12/295 (4%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
+R L G +A I +++ A + G P + I VGD A YVRN+ A+ G
Sbjct: 7 SRYLKGGPVAQRIIAAVREDAAIAKAEGF-PPKLISITVGDTDAVDVYVRNQRAKAQLAG 65
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
ID + IT +L + I LN D V GI++Q PVP I+ + + A+ P KD++G
Sbjct: 66 IDFEERRFPATITSGELEAAIHGLNADPRVTGIIIQRPVPAHISVKTLQAAVHPLKDVEG 125
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
H +IG + + + P TA A VE+LK +D G VV+G S+ VG PIA +L S+
Sbjct: 126 MHPASIGNIVYNQLDLAPCTAAASVELLKETGLDLKGLEVVVVGHSEIVGKPIAFLLMSE 185
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
ATVT+CH T + A+ R AD + A G P+LIKADMVKPGA +ID+G
Sbjct: 186 ---------GATVTVCHHLTRS--VAAHARRADALFVAVGKPRLIKADMVKPGAAVIDIG 234
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
I +G SR+VGDVD + V +A ITPVPGGVGP+TVA+L+ NT A Q
Sbjct: 235 INSEIGPDGTSRIVGDVDTDSVKDVASWITPVPGGVGPITVAILLRNTMVALSRQ 289
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 206 bits (503), Expect = 5e-52
Identities = 117/298 (39%), Positives = 180/298 (60%), Gaps = 16/298 (5%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A+ILDGKA A IK EL +++A+ + G P I ++VG DPAS YV K + + +G
Sbjct: 5 AKILDGKAAAAAIKSELAERVAKLKARGV-TPGIATVLVGADPASQLYVSMKHKQSVEIG 63
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
++++ +D T+ Q+ + I LN D + G +VQLP+P ++ + + I P KD DG
Sbjct: 64 MNSIQRELPADATQAQVEALIDELNADPACHGYIVQLPLPKHLDTDAILERIDPAKDADG 123
Query: 122 FHIINIGRLCV----DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMM 177
H N+GRL + ++ + +P T V+E+L+R G++ VV+GR +G I ++
Sbjct: 124 LHPTNLGRLVLNVSGEITSPLPCTPRGVIELLERNGYSLSGKHVVVVGRGVTIGRTIGLL 183
Query: 178 LHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATI 237
L + ++ATVT+ H T + L R AD+I+ A G ++KA VKPGA +
Sbjct: 184 L-------TRRSVNATVTLTH--TGTENLSQLLRQADVIVGAAGAKHIVKAADVKPGAAL 234
Query: 238 IDVGITRITD-ENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
+DVG+TR TD E GKS++ GD+D +++AG I+P PGGVGPMTVA+LM N +AA+
Sbjct: 235 LDVGVTRETDPETGKSKVHGDID-PAAAEVAGWISPNPGGVGPMTVALLMTNVVEAAE 291
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 206 bits (502), Expect = 7e-52
Identities = 113/296 (38%), Positives = 179/296 (60%), Gaps = 18/296 (6%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M I++G+ +A ++ +E K ++ + G P I I+VGDDPAS Y RNK + A+ +
Sbjct: 1 MTNIINGRQIAKQLNQETKTRVDKLKEEGI-IPGIVVILVGDDPASVIYTRNKQKNAEKL 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
G+ ++ D+++ ++L I + N+D ++ IL+QLP+P +N+ + +AIAPEKD+D
Sbjct: 60 GMKSILRKFPKDVSQAEVLQAIHHYNDDPTIHAILIQLPLPKHLNQTELIEAIAPEKDVD 119
Query: 121 GFHIINIGRLCVDLPTIVP--ATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMML 178
GF+ N+G+L + P T+ ++ +L + G N ++GRS V P+ +L
Sbjct: 120 GFNSKNVGKLYNNEEGHYPVSCTSRGIMTLLHTYLDKIEGLNVTIVGRSILVSRPLQSLL 179
Query: 179 HSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATII 238
+ +ATVT+ +T D ++ Y ++ADI++ A G P LIK D VKPGAT+I
Sbjct: 180 ---------INENATVTMVSLHT--DNIDYYTKHADILVVAAGKPNLIKKDQVKPGATVI 228
Query: 239 DVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
DVGI R+ + LVGDVD+++V ++A ITPVPGGVGPMT+A LM T A+
Sbjct: 229 DVGINRMANH----YLVGDVDFDDVKEVAKNITPVPGGVGPMTIATLMQQTVDLAE 280
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 205 bits (500), Expect = 1e-51
Identities = 121/296 (40%), Positives = 177/296 (59%), Gaps = 11/296 (3%)
Query: 5 LDGKALAMEI---KKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
LDGK LA I KK +K ++ P + I VGD +Y++ K + VG
Sbjct: 86 LDGKLLASHIVSSKKSIKADTEDFIKNSGVTPNLVVIYVGDSKQIESYIKAKRTGCEDVG 145
Query: 62 IDALTINR-DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
T++R SDI E+QL+ +I+ +ED SV GI+VQLP+PD +N+ + +I P+KD+D
Sbjct: 146 FK-FTLDRFSSDIKEDQLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDAIIQSIDPKKDVD 204
Query: 121 GFHIINIGRLCVD-LPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
G N+G++ + P +P T L ++E+LK + I G+N VV+GRS VG IA +L
Sbjct: 205 GLTSTNLGQIMISKKPLYIPCTPLGILEILKAYKIKVEGKNVVVLGRSNLVGRTIATILS 264
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
+ A VTI H+Y+ K+ L + R AD+II+ATG+P LIK + +K G +ID
Sbjct: 265 QKDLTNPSIMNGANVTIIHKYS-KNHLGS-IRQADLIISATGVPGLIKKEDLKRGVILID 322
Query: 240 VGITRITDENGKS--RLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAA 293
VGI+ D KS ++VGD+D E S+ + A TPVPGGVGP+TVA L+ N ++A
Sbjct: 323 VGISFKEDSTKKSGYKMVGDIDPEAYSR-SIAYTPVPGGVGPLTVACLLRNVLRSA 377
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 204 bits (498), Expect = 2e-51
Identities = 110/291 (37%), Positives = 173/291 (59%), Gaps = 13/291 (4%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
+L G A I +K+ I ++AP + +++G++PAS YV K++ A +G+
Sbjct: 2 LLKGAPAADHILATIKENIRAC----SKAPGLAVVLIGNNPASEIYVNMKIKRATDLGMV 57
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+ + + SD T +L+ I LN D ++ GILVQLP+P ++ + + I P+KD+DG H
Sbjct: 58 SKSYRKPSDATLSDILALIHQLNNDENIHGILVQLPLPKHLDAQAILSTITPDKDVDGLH 117
Query: 124 IINIGRLCV-DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
+N+G+L + + +P T +VE+ K + I G++ V++GRS VG P+A +L +
Sbjct: 118 PVNVGKLLLGETDGFIPCTPAGIVELCKYYEIPLHGKHVVILGRSNIVGKPLAALLM--Q 175
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
RH +A+VT+ H + + L R ADI+I+A G+P + +M+ I+DVG
Sbjct: 176 RHAD---TNASVTLLH--SQSEHLTEITRTADILISAIGVPLFVNKEMIAEKTVIMDVGT 230
Query: 243 TRITDENGKSR-LVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
+RI N K LVGDVD+ V + AITPVPGGVGPMTVAMLM NT+++
Sbjct: 231 SRIPAANPKGYILVGDVDFNNVVPVCRAITPVPGGVGPMTVAMLMRNTWES 281
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 203 bits (496), Expect = 4e-51
Identities = 110/290 (37%), Positives = 172/290 (59%), Gaps = 12/290 (4%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
+ILDG ++ +I K++K+KI + + P + I++G++PAS YV K EA G
Sbjct: 4 KILDGLKISKKIIKKIKKKIEKRKKKRKKIPGLAMIVIGNNPASLIYVNKKREACNQAGF 63
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 122
++ + + I E +L++ I+ LN++ +DGIL+QLP+P IN ++ +I P+KD+DGF
Sbjct: 64 FSIYWHLSNQIEEIELINLIKKLNKNKCIDGILIQLPLPIKINYLKIITSIDPKKDVDGF 123
Query: 123 HIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
H N+G LC + P T+ V+ +LK++ I+ G AV+IG S VG P+ M L
Sbjct: 124 HPYNLGSLCQNNPQFRSCTSKGVITLLKKYKINIHGLYAVIIGSSNIVGKPMYMEL---- 179
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
L TVTI ++ T ++ Y + AD+++ A G P + +K GA +ID+GI
Sbjct: 180 -----LLAGCTVTIVNKNT--KNIKTYVKKADLVVIAIGQPNFLYGHWIKLGAIVIDIGI 232
Query: 243 TRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
+ ++N K ++VGDV ++ S ITPVPGGVGPMTV L+ NT QA
Sbjct: 233 NYLYNKN-KYKIVGDVHFKSTSVKTSYITPVPGGVGPMTVVSLLENTLQA 281
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 202 bits (494), Expect = 7e-51
Identities = 112/291 (38%), Positives = 171/291 (58%), Gaps = 20/291 (6%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
ILDGK +A ++K+ L ++ G P + I+VGDDP+S TYVR K A +GI
Sbjct: 45 ILDGKRVAADVKEGLMPRVENLTQKGI-TPCLATILVGDDPSSETYVRMKGNACARLGIR 103
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+ I+ + T E+L+ I+ LNE+ V GIL+Q PVP I+ER+ + I+ +KD+DG
Sbjct: 104 SERIHMPKETTTEELVKTIEELNENKEVHGILLQHPVPGHIDERKAFETISIDKDVDGVT 163
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
G+ + T T A++ ++ +++ G++AVV+GRS +G P++ +L
Sbjct: 164 SHGYGQTALGFGTYPSCTPAAIMAIIDYYHLPVEGKHAVVVGRSPILGKPVSALL----- 218
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
L +ATVT CH YT + L Y AD++I A G P+ IK + +KPGA I+D G
Sbjct: 219 ----LNRNATVTTCHSYT--ENLSRYVGQADLVIAAVGKPEFIKGEWIKPGAVILDAGYN 272
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
+ G VGD +Y+ + A AITPVPGGVGP+T++ML+ +T +AA+
Sbjct: 273 K-----GN---VGDAEYDSCLEKASAITPVPGGVGPVTISMLLKHTVEAAE 315
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 202 bits (494), Expect = 7e-51
Identities = 109/286 (38%), Positives = 165/286 (57%), Gaps = 15/286 (5%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
+I+DGK ++ IK ++ ++I + + R P + I +G++ AS TY++NK A + VG+
Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRVPALTIIQIGNNKASTTYIKNKKIACEKVGV 64
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 122
+N ITE L+ I +LN ++ +D ILVQLP+P IN +V + I +KD+DGF
Sbjct: 65 TCKVLNYPDIITESALIKIINDLNNNSKIDAILVQLPLPSHINSEKVINTIITKKDVDGF 124
Query: 123 HIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
+G L + ++P+T ++ +LK + I G++ V+IGRS VG P+A +L
Sbjct: 125 TPKILGNLMLGHYNLLPSTPKGIIALLKHYQIQLAGQHVVIIGRSNIVGKPLANLL---- 180
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
+ ATVT+CH T L + ADI+I+A G K + A+M+K +IDVGI
Sbjct: 181 -----INASATVTVCHSQT--KNLSDFTNQADILISAVGKAKFVTAEMIKENVIVIDVGI 233
Query: 243 TRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHN 288
R D N L GD+D+ V ITPVPGGVGPMT+A L+ N
Sbjct: 234 NRDEDNN----LCGDIDFHNVFSKVKMITPVPGGVGPMTIAALLEN 275
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 200 bits (489), Expect = 3e-50
Identities = 120/296 (40%), Positives = 167/296 (56%), Gaps = 16/296 (5%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M R L G LA I+ + A LG R P + + DD ++ YVR+ AAK
Sbjct: 1 MTRSLGGAELATSIRNDASVAAAALNDLGTR-PKLAVVQATDDESTAWYVRSIASAAKRT 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI ++ + + EQ+ S + L D V GI++Q P+PD + + +AI P KD+D
Sbjct: 60 GILCDIVDLGAAASTEQIRSTLVELGHDPDVHGIILQTPLPDGTDLDALREAINPAKDVD 119
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
G + +++GRL LP PATA AV+ +L I R A V+GRS VG P+A +L
Sbjct: 120 GANPVSLGRLVARLPAFAPATAQAVIALLDHHGISPHARTATVVGRSTVVGSPVAHLL-- 177
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
+ +ATVT+CHR+T L A R+ADI++ A G+P LI AD V GA +IDV
Sbjct: 178 -------VQRNATVTVCHRHT--TDLAAGTRDADILVVAVGIPGLITADHVADGAVVIDV 228
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
G T D +L+GDVD V AGA+TPVPGGVGP+T A+L+++T AA +Q
Sbjct: 229 GTTATAD----GQLLGDVDAAAVDGRAGALTPVPGGVGPVTTALLLNHTVDAAGTQ 280
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 196 bits (477), Expect = 8e-49
Identities = 108/289 (37%), Positives = 168/289 (58%), Gaps = 21/289 (7%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
I+DGK ++ IK+E+K++I ++ P + ++ GDD +S Y +KV+A + VGI+
Sbjct: 5 IIDGKEISNRIKEEVKREIQEF----GYKPRLAILMAGDDESSKVYANSKVKACESVGIE 60
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
A + S+ E++ ++ LNED GI++++P+P + +V D I P KD+D
Sbjct: 61 A-KVYYFSEKEEDKFFDTLEKLNEDKDTHGIMIEMPLPKGFDVDKVYDTINPYKDVDCIS 119
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
N+GRL P VP T A++ +L+ +D G++AVVIGRS +G P+A +L
Sbjct: 120 NYNMGRLFAGKPLFVPCTPKAIIHILENTGVDLEGKHAVVIGRSNILGKPVAKLL----- 174
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
L + TVT+CH T KD L + + AD+++ A G L++ DMVK G +ID G
Sbjct: 175 ----LDKNCTVTVCHSKT-KD-LAYHTKQADVLVVAAGKMNLVRGDMVKEGVVLIDAG-- 226
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
I GK + GD D+E + A +TPVPGGVGP+T AM++ NT +A
Sbjct: 227 -INVHEGK--IYGDADFESIKDKASYVTPVPGGVGPVTTAMILKNTLEA 272
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 196 bits (477), Expect = 8e-49
Identities = 116/292 (39%), Positives = 167/292 (57%), Gaps = 16/292 (5%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M I++GKA + + K ++ + I + G P I I VGDD S YV N+ + ++ +
Sbjct: 1 MGDIINGKAESQKYKDKIIEFINERKKQGLDIPCIASITVGDDGGSLYYVNNQKKVSESL 60
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI+ +I D I EE+L+ I+ LN DN + GI++QLP+P+ I+ + V I KDID
Sbjct: 61 GIEFKSIFLDESIREEELIKLIEGLNVDNKIHGIMLQLPLPNHIDAKLVTSKIDANKDID 120
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
IN G+ + +P T +++ ++K N+D G+NAVVIGRS VG P A +L
Sbjct: 121 SLTDINTGKFYKGEKSFIPCTPRSIINLIKSLNVDICGKNAVVIGRSNIVGKPTAQLL-- 178
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
L +ATVTICH T L+ C+ ADII++A G P I + V + +IDV
Sbjct: 179 -------LNENATVTICHSRT--QNLKDICKKADIIVSAIGRPGFITDEFVNEKSIVIDV 229
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
G T + +GK R GDV ++EV K A +TPVPGGVG MT ML+ N +A
Sbjct: 230 GTTVV---DGKLR--GDVVFDEVIKKAAYVTPVPGGVGAMTTTMLILNVCEA 276
>UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_147,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 404
Score = 194 bits (474), Expect = 2e-48
Identities = 109/258 (42%), Positives = 163/258 (63%), Gaps = 22/258 (8%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + +VGD PAS +YV K++A + + +DA N ++ +EQL+ IQ +N D
Sbjct: 141 PKLGICLVGDSPASKSYVNRKLKACQEINVDAEVFNFSENVGQEQLIKHIQQMNHD---- 196
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DLPTIVPATALAVVEMLK 150
GILVQLP+P +N+ + +I EKD+D H+ N+ R+ V +L ++P T AV+++L
Sbjct: 197 GILVQLPLPSHLNKLDIIHSIPYEKDVDCLHMHNLQRILVYGELCEMLPCTPAAVLQILD 256
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
++++ G+ +IGRS VG+P++++L KR+ ATVT+CHR T L+ +
Sbjct: 257 YYDVNVIGKKVTMIGRSFLVGLPLSLLLQ--KRN-------ATVTVCHRETLN--LDQHI 305
Query: 211 RNADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAI 270
NADI+I+A G PKL++ VK GA +IDVGI++ K ++VGDVD++ V A I
Sbjct: 306 MNADIVISAAGHPKLVRN--VKQGAIVIDVGISQ---GEKKGKIVGDVDFDVVKNQASLI 360
Query: 271 TPVPGGVGPMTVAMLMHN 288
TPVPGGVGPMTV MLM N
Sbjct: 361 TPVPGGVGPMTVCMLMRN 378
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 194 bits (473), Expect = 2e-48
Identities = 115/293 (39%), Positives = 169/293 (57%), Gaps = 19/293 (6%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
R+LDG+++A EI + + + A+ ++ PT+ ++ DPA+++Y A VG+
Sbjct: 2 RMLDGRSMAAEIGRYVVDE-AERLAAAGVTPTLAVVLPTADPAAYSYAEIIERTAGKVGV 60
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 122
+ + +L I + D +V GI+VQ P+P + R V + I KD+DG
Sbjct: 61 HCVLHEPKGE--PAAILDTIDTVAADPTVHGIIVQTPLPGGLTSREVGEHIPTAKDVDGM 118
Query: 123 HIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
+ ++GRL + LP+ PATA AVVE+L R I G VIGR VG P++++L
Sbjct: 119 NPSSLGRLALGLPSFAPATAAAVVEILTRARIPMSGARVCVIGRGPVVGKPVSLLL---- 174
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
L DATVTICH T L + ADII++ATG P+L+ A V+PGA +IDVG
Sbjct: 175 -----LAEDATVTICHSRT--KGLVSIAHEADIIVSATGHPRLVGAGFVRPGAAVIDVG- 226
Query: 243 TRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQS 295
+ E G+ VGDVD VS +AGA+TPVPGGVGP+T +L+ NT +AA++
Sbjct: 227 -TVVTETGQ---VGDVDAAAVSSVAGALTPVPGGVGPVTTMLLLRNTIRAARA 275
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 193 bits (470), Expect = 5e-48
Identities = 106/300 (35%), Positives = 173/300 (57%), Gaps = 12/300 (4%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
+A++LDG A++ I + L + + + G P + ++VG++PAS +YV +K K +
Sbjct: 2 VAKVLDGLAVSAGIFERLHRACCELENNGV-CPKLATVLVGNNPASRSYVLSKHRDCKNI 60
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI + I ++ +E++L+S+++ LN + V GI+VQLP+P++I++ +V +AI P+KD D
Sbjct: 61 GIQSTLIELPANTSEKELISKVEILNASSDVSGIIVQLPLPESIDQNKVIEAINPDKDAD 120
Query: 121 GFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
G H +N+G L IVP T +V++L+ I G+ VIGR VG P+ ++L
Sbjct: 121 GLHPLNLGYLVTGKQGIVPCTPAGIVKLLEAHRITLEGKTIAVIGRGTTVGRPLGILL-- 178
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
SG G++ATV H + + R AD+++ G+ +++ +KPGA ++DV
Sbjct: 179 -----SGKGVNATVINIH--SRSRNISGLSRIADVVVACAGVKHIVEPSWIKPGAVVVDV 231
Query: 241 GITRI-TDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
GI + +GK L GDV + IA I+PV GGVGPMT AMLM N ++ K
Sbjct: 232 GINQSGVSSSGKMILTGDV-HPLTKNIASYISPVVGGVGPMTRAMLMSNVINLSERDFRK 290
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 190 bits (464), Expect = 3e-47
Identities = 111/299 (37%), Positives = 175/299 (58%), Gaps = 14/299 (4%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A++L+GK +A + +++ +++A G +P + I+VGDD S +YV K E K VG
Sbjct: 3 AQLLEGKVVAAAVLEDVARRVAVLKDKGI-SPGLGTILVGDDGPSVSYVNKKRETCKQVG 61
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I + + T+ LL+ +++ N+ VD ++Q P+P + + + PEKD DG
Sbjct: 62 IASFHNEIPASATQSDLLAAVRDFNDSPDVDAYIIQYPLPKGFDFNEALNLMLPEKDADG 121
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
H +N+GRL + P VP T + ML+ ++I G+ VVIGR +G P++++L
Sbjct: 122 LHPVNLGRLVLQEPGPVPCTPAGIRAMLQHYDIAIEGKEVVVIGRGPTLGRPLSLLLTLK 181
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
+ + +A VT+ H KD L AY R ADI+I A G P +++ DM++PGA +I G
Sbjct: 182 QPY-----ANAAVTVVHSGI-KD-LGAYTRRADIVIAAAGCPGIVQPDMIRPGAVVISGG 234
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANKS 300
I+ G+ +L+ DVD E V ++AG ITP GGVGP TVAML+ NT QAA+ +A ++
Sbjct: 235 IS----WEGR-KLLPDVD-EAVGEVAGWITPRLGGVGPTTVAMLLLNTVQAAEERARRA 287
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 189 bits (461), Expect = 7e-47
Identities = 119/302 (39%), Positives = 167/302 (55%), Gaps = 20/302 (6%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCII-VGDDPASHTYVRNKVEAAKF 59
+A I+ G + ++ ++ QKIA+ + I+ VG+ S+ Y+ +K++ AK
Sbjct: 2 VAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAKE 61
Query: 60 VGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVP--DTINERRVCDAIAPEK 117
+G D I IT+ L EI LN DN +DGI++QLP+ I+ V D I P K
Sbjct: 62 IGADGKLIKLPDTITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPLK 121
Query: 118 DIDGFHIINIGRLCV-DLP-TIVPATALAVVEMLKRFNIDT---FGRNAVVIGRSKNVGM 172
D+DG IN GRL +L TI P T + ++++ D G+ VV+GRSK VG
Sbjct: 122 DVDGLTRINAGRLARGELQRTIFPCTPFGCLYLVQQATGDANFVSGKEVVVLGRSKIVGS 181
Query: 173 PIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVK 232
P A + L TVTICH TP L+ C ADI+I A G +KAD +K
Sbjct: 182 PAAALF---------LWHHGTVTICHSKTPN--LKEKCLRADILIVAIGRKHFVKADWIK 230
Query: 233 PGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
PGA +ID GI + D+ ++ GDVD E ++AG +TPVPGGVGPMTVAML+ NTF+
Sbjct: 231 PGAFVIDCGIN-VGDDPNSRKIYGDVDTEAAKEVAGFLTPVPGGVGPMTVAMLIRNTFEQ 289
Query: 293 AQ 294
A+
Sbjct: 290 AK 291
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 185 bits (451), Expect = 1e-45
Identities = 109/269 (40%), Positives = 159/269 (59%), Gaps = 19/269 (7%)
Query: 40 VGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLP 99
VGD S+ Y+ K++AA +GIDA + S T+E++L I ++NED SV G++VQLP
Sbjct: 89 VGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQEEVLLNILSINEDQSVHGLIVQLP 148
Query: 100 VPDT--INERRVCDAIAPEKDIDGFHIINIGRLCV-DLPT-IVPATALAVVEMLKRFNID 155
+ I+ + + ++ +KD+DG IN GRL DL +P T +E++++ +
Sbjct: 149 LDSVHHIDSECITNTVSADKDVDGLSCINAGRLSRGDLDACFLPCTPSGCLELIRQTGVS 208
Query: 156 TFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADI 215
G+ AVVIGRSK VG P+ H+ L ATVT CH TP L ADI
Sbjct: 209 LEGKQAVVIGRSKIVGAPM---------HDLLLWNHATVTTCHSKTPD--LPEQVGRADI 257
Query: 216 IITATGLPKLIKADMVKPGATIIDVGITRITD---ENGKSRLVGDVDYEEVSKIAGAITP 272
++ G ++++ + +K GA +ID GI ++ D +GK R+VGDV Y + AG ITP
Sbjct: 258 LVVGAGRAEMVRGEWLKEGAVVIDCGINQVPDCTRASGK-RVVGDVHYASAHQRAGFITP 316
Query: 273 VPGGVGPMTVAMLMHNTFQAAQSQANKSN 301
VPGGVGPMTVAMLM NT ++AQ +K++
Sbjct: 317 VPGGVGPMTVAMLMQNTVRSAQRYLSKTH 345
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 184 bits (449), Expect = 2e-45
Identities = 105/290 (36%), Positives = 169/290 (58%), Gaps = 13/290 (4%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
+ +GK A + LK+ + Q +L ++ ++ ++ D+PAS+ YV K AK +G++
Sbjct: 11 VFNGKDFANKYYLMLKEFLKQH-NLRDKI-ALKVVLANDEPASNLYVSIKSRVAKEIGLN 68
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
I ++ + +L I N++ S DGI+VQLP+ ++ + ++I KD+DG
Sbjct: 69 VEVIKFSANSVQSDILEVIDRENKNLSTDGIIVQLPLLKGMDLNSILNSIVYSKDVDGLS 128
Query: 124 IINIGRLCV-DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
+N+G++ + D +P TALAV+++L+ I T G+ VV+GRS VG PI+++L S
Sbjct: 129 FVNLGKMILGDKKGFIPCTALAVLKILRDEGIKTLGKTVVVVGRSPLVGRPISILLSSKP 188
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
DATV +CH + L+ Y R ADI+I+A G P+LI M+ +ID+GI
Sbjct: 189 -------YDATVIVCH--SKSIYLDVYLRQADIVISAVGKPRLIDKSMLCGKPYVIDIGI 239
Query: 243 TRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
+ I +NGK L GD D++ + + ITPV GG+GP+TV MLM NT +A
Sbjct: 240 SEIETDNGKI-LSGDTDFDNIKECVKFITPVKGGIGPVTVLMLMFNTIKA 288
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 177 bits (431), Expect = 3e-43
Identities = 114/296 (38%), Positives = 162/296 (54%), Gaps = 13/296 (4%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M I+DGK LA E K + + I+VG++ AS YV NKV AK +
Sbjct: 1 MTVIMDGKKLAELRLIETKNDLLALKDKYQITVKLVIILVGNNDASLIYVNNKVAKAKAI 60
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
G+D+ I I E++L S I +LN D++V GI+VQLP+P I+ ++ I KD+D
Sbjct: 61 GMDSEIIRLFEFIEEKKLFSVIDDLNCDSTVHGIIVQLPLPPHIDALKLFARIDSRKDVD 120
Query: 121 GFHIINIGRLCVDL-PTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
G + INIG L + ++P TAL +++L+ + G++ VVIG+S VG P++ +L
Sbjct: 121 GLNPINIGYLNIGANQGLIPCTALGCIDLLQYYVTGLKGKHVVVIGKSNIVGKPLSALL- 179
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
L TVTICH T L + R ADI+I+A G + ID
Sbjct: 180 --------LRNSCTVTICHSATV--DLALHTRTADIVISAVGKANFLTDKHFSGNLAFID 229
Query: 240 VGITRITD-ENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
VGI+ I D + K +LVGD D+ ++ + ITPVPGGVGPMTVA L+ NT AA+
Sbjct: 230 VGISHIYDLQTHKRKLVGDGDFLKIKDLVKFITPVPGGVGPMTVAYLLKNTLTAAK 285
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 175 bits (426), Expect = 1e-42
Identities = 106/290 (36%), Positives = 166/290 (57%), Gaps = 14/290 (4%)
Query: 4 ILDGKALAMEIKKELKQKIA--QWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
+ +G A +I L+++I Q S +R P + I+VG++PAS +Y++ K++A + +G
Sbjct: 18 VFNGNKSAKKILSSLRKEIEWFQKQSDLSRKPGLGIILVGNNPASLSYIKKKLQACEAIG 77
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I + DI E +LS I NLN + +D I+ QLP+P I++ V + I+ EKD DG
Sbjct: 78 IRHELYHFSEDIQEYDVLSAIDNLNRKDDIDAIMAQLPLPSHIDKNNVINMISSEKDADG 137
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
+ N L I+P T A +++L+ I ++ V+IGR + VG P+ +L
Sbjct: 138 LKL-NSNNLDPKA-NILPCTPAACLKILEEHQICLKDKHVVLIGRGRLVGQPLEQLL--- 192
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
S L A +T C + T ++ + AD+II A G +LIK +K GA ++DVG
Sbjct: 193 ----SKLS-PAQITTCVKET--GDIKQHILKADVIIAAAGERQLIKGKWIKKGAIVLDVG 245
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQ 291
+ + +++VGDV++EE K A ITPVPGG+GPMTV+MLM+NT Q
Sbjct: 246 VNKGIPGIDPTKVVGDVEFEEAKKRASLITPVPGGIGPMTVSMLMYNTVQ 295
>UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycoplasma
agalactiae|Rep: FolD bifunctional protein - Mycoplasma
agalactiae
Length = 286
Score = 175 bits (425), Expect = 2e-42
Identities = 108/294 (36%), Positives = 165/294 (56%), Gaps = 22/294 (7%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
IL+GK +A E ELK++ + L R P + I VGD+PAS Y++NK++ A+ +G+
Sbjct: 3 ILNGKIIAEERTVELKKEFEEITKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGVK 62
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF- 122
A D DI++ LL ++ LNE++ DGI+VQLP+P+ I+ + + + I EKD+DG
Sbjct: 63 ATLYKFDEDISQNSLLKKLDVLNEES--DGIIVQLPLPEHISPKVIMNGIRLEKDVDGLC 120
Query: 123 --HIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHS 180
N D + PATA A+++++ + ID G+ A VIGRS VG P A +L
Sbjct: 121 EKSTFNFYNDKYDELSFTPATAAAIIDLINYYKIDLNGKKAAVIGRSYLVGKPTAFLLKK 180
Query: 181 DKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDV 240
+ A V+ ++ T + +E +AD++++A G P L+K + +K GA +ID
Sbjct: 181 ---------LGAMVSTYNKNTGINGVE----SADLLVSAAGQPDLVKKENIKDGAWLIDA 227
Query: 241 GITRITDENGKSRLVGDVDY--EEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
G T I + GK VGD EE + G TP PGG+GP+TV L N +A
Sbjct: 228 GTTMI-EREGKKCFVGDASLTPEEYQLLEG-YTPTPGGIGPLTVIWLFKNLAKA 279
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 173 bits (422), Expect = 4e-42
Identities = 101/272 (37%), Positives = 159/272 (58%), Gaps = 18/272 (6%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I VG++P+S TYVR K+ + I + I++++++ I++LN+ S+D
Sbjct: 37 PGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQKEIVHRIKSLNQKGSID 96
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DLPTIVPATALAVVEMLK 150
GILVQLP+P ++ + + I KDID H+ N L + I+P T AV+ +L
Sbjct: 97 GILVQLPLPPHLSRLEISNEIKLNKDIDCLHMANFQNLLQNGEDNDIIPCTPAAVLHILD 156
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
NID +N VIGRS+ VG P++++L L +A VTICH T ++ +
Sbjct: 157 TQNIDVRNQNVTVIGRSQLVGFPLSVLL---------LKRNARVTICHSET---TVQEHV 204
Query: 211 RNADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAI 270
ADI+I+ G +L+K + +K GA +IDVGITRI G +++VGD+++++ I
Sbjct: 205 EKADIVISCAGHKELVKGEWIKNGAKVIDVGITRIP---GTNQIVGDIEFQKALPRVSFI 261
Query: 271 TPVPGGVGPMTVAMLMHNTFQA-AQSQANKSN 301
TPVPGGVGP+TV+ML N ++ +S K+N
Sbjct: 262 TPVPGGVGPLTVSMLFRNLYRVWCRSNGLKAN 293
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 172 bits (419), Expect = 8e-42
Identities = 118/290 (40%), Positives = 168/290 (57%), Gaps = 23/290 (7%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
+IL G+ A + K+LK+++ + ++L NR + I VGD S+ YV K++ AK +GI
Sbjct: 2 KILSGREKAEQDLKQLKKELDE-LNL-NRPIKLAIIQVGDKMESNRYVEQKLKKAKEIGI 59
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 122
+A D +IT+++LL + +NE+ DGIL+QLP+P + + + DA+ EKDIDG
Sbjct: 60 EAKCFKFDENITQKRLLLAMDEINEN--WDGILIQLPLPKHLPKEVILDAVPYEKDIDGL 117
Query: 123 ----HIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMML 178
I D VPA A AV+E+++ I+ + V+GRS VG P+A +L
Sbjct: 118 SHRNEFILYNEKNSDDKFFVPAAARAVLELIEHHEINYKKKKVAVVGRSHLVGKPVAHIL 177
Query: 179 HSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATII 238
KR A+V+ TP KL A +ADI+I A G+PK IKA+ +K GA II
Sbjct: 178 ---KRR------GASVSTFDENTPI-KLVA---SADIVIVAIGVPKYIKAENIKQGAIII 224
Query: 239 DVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHN 288
DVG D+N S + GDVD+E V A AITPVPGGVGP+TV L+ N
Sbjct: 225 DVGTNY--DQNDPSVIFGDVDHESVKTKASAITPVPGGVGPLTVVCLLKN 272
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 172 bits (419), Expect = 8e-42
Identities = 109/298 (36%), Positives = 159/298 (53%), Gaps = 17/298 (5%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
+I+ GK +A +I +EL +++ V G P + + VG +Y R ++ + +GI
Sbjct: 9 QIIKGKPVADKISEELIKEVDLLVKEGIN-PKLTIVRVGARSDDLSYERGALKRCQNIGI 67
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 122
+ DIT+E+ + ++ +N+D +V+GIL P+P +NE + IAPEKD+D F
Sbjct: 68 TTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCFRPLPKHLNEEVIKYVIAPEKDVDCF 127
Query: 123 HIINIGRLCV-DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
IN ++ D P T AVVE+LK +N+D G V+GRS VG P++M+L S+
Sbjct: 128 SPINSAKVMEGDKSGFPPCTPTAVVEILKHYNVDLKGSKVTVLGRSMVVGKPVSMLLLSE 187
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
ATVTICH T L AD++I A G K++ VK GA +IDVG
Sbjct: 188 ---------HATVTICHSKT--KNLSGVAAEADVLIAAIGRAKMVDESFVKDGAVVIDVG 236
Query: 242 ITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
I DE G L GDVD V ITPVP GVG +T ++L + +A + Q NK
Sbjct: 237 IN--VDEEG--NLCGDVDTNAVLDKVSMITPVPAGVGSVTTSILAKHVVKACKLQNNK 290
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 170 bits (414), Expect = 3e-41
Identities = 98/296 (33%), Positives = 171/296 (57%), Gaps = 23/296 (7%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 62
++L G+ +A + +ELK++I + +P + + VG+ A+ Y R K++ K +G
Sbjct: 4 KLLKGEEIAEKKAEELKERIEKM----GVSPRLVLLQVGNYSAATIYARAKIKRGKKIGA 59
Query: 63 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 122
D + + + D+T+++L+ I+ L+ D V+GI+V+ P+P TI+ + +I KD+D
Sbjct: 60 DVV-LEKYEDLTKQELVRRIEELSADKDVNGIMVENPLPKTIDYYDIVKSIPYYKDVDAL 118
Query: 123 HIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
N G + ++ +VPATA+AVV++LK + + A +I RS VG P++MM+
Sbjct: 119 SPYNQGSIAINREFLVPATAMAVVDILKYYGYEK--TTATIINRSPVVGRPLSMMM---- 172
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
L D TV+ICH TP + + + + II+ A G P + V + +IDVGI
Sbjct: 173 -----LNRDYTVSICHSKTP--DIRSIAKASKIIVVAVGRPGFLDDTYVTESSVVIDVGI 225
Query: 243 TRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQAN 298
+ D +++GD+D+++VS+ A+TPVPGGVGP+T ++ N +AA+ Q+N
Sbjct: 226 NYVQD-----KVIGDIDFDKVSEKVEAVTPVPGGVGPITATNILSNLVKAAEYQSN 276
>UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Leuconostocaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 285
Score = 168 bits (408), Expect = 2e-40
Identities = 103/298 (34%), Positives = 162/298 (54%), Gaps = 20/298 (6%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M +ILDG++++ +I +E+K K+A+ + I ++ S YV K+ A F
Sbjct: 1 MVQILDGRSVSKKILQEVKDKVAK----AGFPVKLATIYNEENEGSKMYVGMKIRRATFA 56
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
G+ ++ D+ + +L + LN D+S+ GILVQ P+ D I+E ++ +AI P KD D
Sbjct: 57 GLISVEYKVDNSWKTDDILRLLSKLNMDSSICGILVQSPLGDGIDESKIFNAIDPLKDAD 116
Query: 121 GFHIINIGRLCVDLPT--IVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMML 178
G N G L + IVPAT V+ +L+ ++ +NA+V+GRS G P++++L
Sbjct: 117 GLSAFNQGLLFENAKENYIVPATPAGVISLLEAYHYQFAAKNALVVGRSVLFGRPMSVLL 176
Query: 179 HSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATII 238
D TVT+ H TP D+L + + AD+I+ A G + +K +I
Sbjct: 177 ---------TNRDMTVTLAHSKTPVDQLRQFAKRADLIVVAIGKANWFQFTDLKKDVVVI 227
Query: 239 DVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
DVG ++ NG + GDVD+E+V I+PVPGGVGPMT+A L+ +TF A Q
Sbjct: 228 DVGANKL---NGHA--TGDVDFEKVYPHVSQISPVPGGVGPMTIATLIKHTFDLAVFQ 280
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 167 bits (407), Expect = 2e-40
Identities = 107/295 (36%), Positives = 162/295 (54%), Gaps = 16/295 (5%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
MA +L G +A + +EL + A G P + + VG+ +Y R ++ + V
Sbjct: 1 MAELLKGAPVARALTEELAARCAALREQGV-VPMLAIVRVGEREDDLSYERGALKRCEKV 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
GI+A + D+++++LL+ I+++N D +V G L+ P+P ++E V A+ P KD+D
Sbjct: 60 GIEARRVLLPVDVSQDELLAAIKDINADPAVHGCLMFRPLPAGLDEDAVAAALDPAKDVD 119
Query: 121 GFHIIN-IGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
+ + L P TA AV+ +L + ++ G V+GRS +G P+A ML
Sbjct: 120 SMTPASLLTTLSGRGEGFAPCTAEAVLALLDHYGVELDGAKVAVVGRSLVIGRPVAAML- 178
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
+ATVT CH +T +D L A CR ADI++ A G + I AD V+ G TIID
Sbjct: 179 --------TARNATVTTCHTHT-RD-LAAECRAADIVVAAVGRARTIGADAVRGGQTIID 228
Query: 240 VGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
VGI DE +LVGDVD++ I GAITPVPGGVG +T A+L + +AA+
Sbjct: 229 VGIN--WDE-AAGKLVGDVDFDAAEPIVGAITPVPGGVGAVTTAILAKHVIEAAE 280
>UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 272
Score = 165 bits (402), Expect = 9e-40
Identities = 104/285 (36%), Positives = 159/285 (55%), Gaps = 22/285 (7%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
++ GK + +IK+ ++Q A+ V +G + I VGDDP+S YVR + A+ G+
Sbjct: 2 LIYGKDIREQIKERVRQS-AEEVKMG-----LAIIRVGDDPSSMAYVRGIRKFAEETGVK 55
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+N + E +LL I +LN + + GI++Q P+P ++N + +AI +KD++G H
Sbjct: 56 VEIVNLPDAVGERELLKTIGDLNNSSEITGIMLQTPLPASLNASHLVNAIDFDKDVEGIH 115
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
N+G+L + P T AV+ MLK +I G+ +IGRS VG P+A+M+ ++
Sbjct: 116 NYNLGKLISKEEGVRPCTPKAVISMLKAHDILIEGQKVTIIGRSMTVGSPLALMMTAE-- 173
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
+ATVT+CH T K EA ADI++ A G + + ADMV +IDVGI
Sbjct: 174 -------NATVTVCHTRTRNLKEEAL--RADILVAAVGKREFVTADMVHKDMVVIDVGIN 224
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHN 288
DENGK ++GDV +EE + VPGG+G +TVA L N
Sbjct: 225 --FDENGK--MLGDV-HEEARNHCRLASAVPGGIGVITVAELFDN 264
>UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermotogaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermotoga maritima
Length = 271
Score = 165 bits (400), Expect = 2e-39
Identities = 104/292 (35%), Positives = 168/292 (57%), Gaps = 25/292 (8%)
Query: 5 LDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 64
+D K +A I++ K+++ + LG P + + DDP++ +Y++++ + A+ +GI
Sbjct: 3 IDCKTIARSIEERTKERVEK---LGF-TPKLVSVACTDDPSALSYLKSQRKKAEKLGIAF 58
Query: 65 LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHI 124
+N ++ E+++S ++ L D SV+G+ V P P ++E+ + ++ EKD++G +
Sbjct: 59 EIMN----VSPEEIVSTLKKLGSDESVNGVFVARPFPLGLDEKEILSSVPVEKDVEGVNP 114
Query: 125 INIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRH 184
N+G L D P TA A V +L+R + G+ V+GRS VG P+A+ML
Sbjct: 115 ANLGLLLYDEEIFPPCTAEAAVRILER-ETNLSGKRVTVVGRSVTVGKPLALMLLKK--- 170
Query: 185 ESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITR 244
G DATVT+CH T LE +N+DI++ A G +K +MVK GA +IDVGI
Sbjct: 171 ----GRDATVTVCHSRTV--NLEEITKNSDIVVVAVGRAHFLKKNMVKEGAIVIDVGINY 224
Query: 245 ITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
+ +GK L GDVD V +IA +TPVPGGVG +T A+L + +AA+ Q
Sbjct: 225 V---DGK--LQGDVD-PSVEEIA-RVTPVPGGVGQVTTALLFEHVVRAAERQ 269
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 159 bits (385), Expect = 1e-37
Identities = 88/202 (43%), Positives = 121/202 (59%), Gaps = 13/202 (6%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I VG P S YV+ K++AAK I + + D D++EE LL EI LN+D V+
Sbjct: 76 PNLTIIQVGGRPDSSAYVKAKLKAAKSSNILSSLLKFDEDMSEEDLLEEIDRLNKDPKVN 135
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DLPTIVPATALAVVEMLK 150
G+L+QLP+P NE + +A+A EKD+DGF N+G L P P T ++E++K
Sbjct: 136 GLLIQLPLPKHFNETLITNAVATEKDVDGFARYNVGELTKKGGAPMFKPCTPNGIMELIK 195
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
I G+NAVV+GRS VG P+A ML ++ D TVTICHR+T L +
Sbjct: 196 TTGISLRGKNAVVLGRSDIVGTPVAAMLRNE---------DCTVTICHRHT--YDLPSVV 244
Query: 211 RNADIIITATGLPKLIKADMVK 232
RNADII+ A G+P+ +KAD VK
Sbjct: 245 RNADIIVAAVGIPEYVKADWVK 266
>UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Rubrobacter xylanophilus DSM 9941|Rep: Bifunctional
protein folD 2 [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 320
Score = 158 bits (384), Expect = 1e-37
Identities = 105/308 (34%), Positives = 154/308 (50%), Gaps = 23/308 (7%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
AR++DG+ +A E+KK + ++ + G R P + ++VG+D A+ Y R A +G
Sbjct: 3 ARVIDGRPIAGELKKRVASEVEGLAARGVR-PGLATVLVGEDYAARAYERRVGGLAAELG 61
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+ + E +L+ + LN D V GILV P+P I+E V A+ P KDI+
Sbjct: 62 CRYVCERLPREAEEADVLAVVGKLNADPRVSGILVLRPLPGHISEPAVFSALDPLKDIEA 121
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGR---------NAVVIGRSKNVGM 172
H +N G L + P VP+T A +L R+ ++ GR VV+GRS NVG
Sbjct: 122 VHPVNAGLLALGRPRYVPSTPAACFYLLDRY-LERSGRPPEEFYPRSTVVVVGRSNNVGK 180
Query: 173 PIAMMLHSDKRHESGLGMDATVTICHRYTPK-DKLEAYCRNADIIITATGLPKLIKADMV 231
P + G A V C + +L + AD +I A G+ LI V
Sbjct: 181 PAVSL---------GFARGAAVISCDANAYRAGRLREHTLKADALIVAAGVAGLIDESYV 231
Query: 232 KPGATIIDVGITRITDENGKSR--LVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNT 289
+ G +DVGI + D G R LVGD+D+ V++ A A+TPVPGGVGP+T L+ NT
Sbjct: 232 REGVIAVDVGINPVADPGGSGRTLLVGDLDFGSVARKAEALTPVPGGVGPITDVWLLKNT 291
Query: 290 FQAAQSQA 297
A + A
Sbjct: 292 VAAGRGLA 299
>UniRef50_A6LP88 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Thermosipho
melanesiensis BI429|Rep: Tetrahydrofolate
dehydrogenase/cyclohydrolase - Thermosipho melanesiensis
BI429
Length = 271
Score = 157 bits (381), Expect = 3e-37
Identities = 104/291 (35%), Positives = 163/291 (56%), Gaps = 25/291 (8%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
I+D K L +IK L ++I + R P + + DP++ +Y++++ +AAK G+D
Sbjct: 2 IIDVKPLYEDIKVNLLKRIEKL----KRTPKLVAVTFKPDPSTVSYLKSQEKAAKRFGLD 57
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+S ++L+E L+ DN+V+GI V P+ +NE + + + P KDI+G H
Sbjct: 58 YEIFEGNSPKGVLKILAE---LSRDNNVNGIFVTHPLSQ-VNEMEIFENLVPSKDIEGRH 113
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
N+G L P TA AVV +++ I G+N V++GRS VG P+A+ML R
Sbjct: 114 PYNLGMLAYGEEFFAPCTAEAVVRIMEN-EIGIPGKNVVIVGRSNTVGKPLAIMLLRRDR 172
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
ATVT+CH T L + + AD+++ A G P LI DMV+ + IIDVGI
Sbjct: 173 -------SATVTVCH--TKTRNLSSITKGADVVVAAAGRPGLITVDMVEKDSIIIDVGI- 222
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
+TDE ++GDV ++V+ A +TPVPGGVG +T +LM + ++A+
Sbjct: 223 NVTDEG----IIGDVS-KDVANFA-KVTPVPGGVGKITTILLMEHLVKSAE 267
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 155 bits (377), Expect = 1e-36
Identities = 94/280 (33%), Positives = 155/280 (55%), Gaps = 20/280 (7%)
Query: 13 EIKKELKQKIAQWVSLGN-RAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDS 71
+I K++ QK+ + + N R P + I+VG+ S +YV K A K VG+ + I+
Sbjct: 35 KISKDVLQKVKERILRVNIREPKLAIILVGNAADSISYVSVKQRACKRVGVQSELIHLPE 94
Query: 72 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC 131
T+++++ +++LN+ VD IL QLP P I++ V + I P KD+DG + +
Sbjct: 95 TTTQKEVIQIVEDLNKREDVDSILTQLPFPAQISKTIVINQIEPSKDVDGLQRCFLTQQL 154
Query: 132 V---DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGL 188
+ +P T + + +L ID G+ V++G+ VG P+ +L L
Sbjct: 155 IWDDHNNRALPCTPQSCLHILDTHKIDVKGKQVVMLGKGLLVGSPLGAIL---------L 205
Query: 189 GMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITRITDE 248
G A V++C + K L ++ADI+++ATG+ KL+K + +K G +IDVG +R
Sbjct: 206 GRGAIVSMCDK---KSDLSIALKDADILVSATGVRKLVKGEQLKKGVIVIDVGCSRPLPH 262
Query: 249 NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHN 288
+S +VGDV++E A +TPVPGGVGP+TV+ML+ N
Sbjct: 263 EDQSSIVGDVEFES----ASLLTPVPGGVGPVTVSMLIQN 298
>UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasmatales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Picrophilus torridus
Length = 276
Score = 155 bits (376), Expect = 1e-36
Identities = 101/293 (34%), Positives = 153/293 (52%), Gaps = 21/293 (7%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
I+DG ++ + LK +I + + G P ++ I++G+D S Y + K+ +GID
Sbjct: 2 IIDGVKISETKMERLKNEIEKIKNTGIN-PKMKIILIGNDYGSVVYSKAKMRRGSKLGID 60
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+ ++R I+ E L+ ++ ++ + + GI+++ PVP IN V + I KD+DG
Sbjct: 61 -VDLDRYDSISREDLIKLLKRYSQSDDIHGIMIETPVPG-INYYDVVNEIPFYKDVDGMT 118
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
N+G L + I PATA AVV++L NI + N +I RS VG P++MML
Sbjct: 119 SYNLGNLYLKNEFIAPATARAVVDILDYINIKS--GNVAIINRSPVVGRPLSMML----- 171
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
L D TVT+CH T + R++DI++ A G P + V IIDVGI
Sbjct: 172 ----LNRDFTVTVCHSRTVN--INEITRSSDIVVVAVGKPNFLDRSYVSDKNIIIDVGIN 225
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
+ NGK+ GD DYE + AITPVPGGVGP+T + N + Q
Sbjct: 226 YL---NGKT--CGDADYENIKDYVNAITPVPGGVGPVTATDIFENFINGLKYQ 273
>UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1; n=11; Viridiplantae|Rep:
Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1 - Zea mays (Maize)
Length = 160
Score = 153 bits (370), Expect = 7e-36
Identities = 84/171 (49%), Positives = 107/171 (62%), Gaps = 15/171 (8%)
Query: 116 EKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMP 173
EKD+DGFH +NIG+L + P +P T +E+L R I G+NAVV+GRS VG+P
Sbjct: 1 EKDVDGFHPLNIGKLAMKGRQPLFLPCTPKGCIELLHRSGISIKGKNAVVVGRSNIVGLP 60
Query: 174 IAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKP 233
++++L L DATVTI H T + E R ADIII A G +IK +KP
Sbjct: 61 VSLLL---------LKEDATVTIVHSRTKEP--EKIVREADIIIAAAGQAMMIKGSWIKP 109
Query: 234 GATIIDVGITRITDENGKS--RLVGDVDYEEVSKIAGAITPVPGGVGPMTV 282
GA +IDVG + D KS RLVGDVD++E K+AG ITPVPGGVGPMT+
Sbjct: 110 GAAVIDVGTNAVDDPTRKSGYRLVGDVDFQEACKVAGWITPVPGGVGPMTI 160
>UniRef50_A4M873 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Petrotoga mobilis
SJ95|Rep: Tetrahydrofolate dehydrogenase/cyclohydrolase
- Petrotoga mobilis SJ95
Length = 273
Score = 152 bits (369), Expect = 9e-36
Identities = 100/280 (35%), Positives = 158/280 (56%), Gaps = 23/280 (8%)
Query: 17 ELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEE 76
E+K +I+ P + ++V D ++ +Y+ ++ AK GI+ L I +D+T
Sbjct: 11 EIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGIN-LEIVESNDLT-- 67
Query: 77 QLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT 136
++++ NED+ D I + P+ E + I PEKD++G + NIG + +
Sbjct: 68 ---NDLRKYNEDDDTDAIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFYEKEL 124
Query: 137 IVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTI 196
VP TA AVV++++ D G+N V++GRS VG P A+ML +RH G DATVT+
Sbjct: 125 FVPCTAEAVVKIIED-TTDVRGKNIVILGRSTTVGKPAAIML---QRH----GRDATVTV 176
Query: 197 CHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVG 256
H T L+ + ADI++ A G + + VK G +IDVGI + +GK +VG
Sbjct: 177 TH--TKTKNLKEITKEADILVAAIGKANFVDSTFVKEGMIVIDVGINVV---DGK--IVG 229
Query: 257 DVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
DV+ ++VS+I +TPVPGGVG +T A+LM N F+AA ++
Sbjct: 230 DVN-KDVSEIC-QLTPVPGGVGSVTTAILMRNVFRAANNK 267
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 151 bits (366), Expect = 2e-35
Identities = 109/306 (35%), Positives = 154/306 (50%), Gaps = 25/306 (8%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
IL G+ +A + ++K +A S + P + I VG+ P S Y++ K + AK GI
Sbjct: 6 ILYGRQVAQAVGHKIKLDVALLKSSFDVYPKLVVIEVGELPQSKLYIKQKFKFAKKYGIL 65
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPV-PDT-INERRVCDAIAPEKDIDG 121
+ S I+E LL + LN D+SV GI +QLP DT IN +A+A KD++G
Sbjct: 66 LSHMRLPSHISESLLLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVEG 125
Query: 122 FHIINIGRLCVDLPTIV-----------PATALAVVEMLKRFNIDTFGRNAVVIGRSKNV 170
+ N L V + + TA A +++ N G V+IGR + V
Sbjct: 126 LNSYNTALLSVVIYSATLRRLKTKTYSYTCTAAACYALIRHVNFPISGSRCVIIGRGRLV 185
Query: 171 GMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADM 230
G P A +L SG ATV CH + ++ DIII+ G P LIK D
Sbjct: 186 GAPTAELL-------SG-SCGATVIQCHLQSA--NIDEEINRGDIIISGVGHPGLIKGDW 235
Query: 231 VKPGATIIDVGITRITDEN--GKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHN 288
V+PGA +ID G + + D KSR GDV++ + A ITPVPGGVGP+++AML N
Sbjct: 236 VRPGALVIDCGYSVMNDPQNPSKSRCFGDVEFNTALEKAKWITPVPGGVGPVSIAMLFRN 295
Query: 289 TFQAAQ 294
T +AQ
Sbjct: 296 TVNSAQ 301
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 148 bits (358), Expect = 2e-34
Identities = 93/269 (34%), Positives = 144/269 (53%), Gaps = 20/269 (7%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + + + DD AS YV K++ A +G+ I+ T++ L+ +I LN D+S+D
Sbjct: 30 PHMAIVKINDDAASDKYVSIKLKKAAELGVKTTLISEGIK-TQDDLIKQIHILNNDDSID 88
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DLPTIVPATALAVVEMLK 150
G ++QLP+P + +C+ I KDIDG I R +L P TA ++E+LK
Sbjct: 89 GYIIQLPLPKGFDSNVICEHIDVNKDIDGLSSFAISRNLANSNLFHPKPCTANGIIEILK 148
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
+ N G++AV+I RS VG P+ + L +ATVT+CH T L+
Sbjct: 149 QSNYSIEGKHAVIINRSMIVGKPLIGLF---------LENNATVTVCH--TKTQNLKEMT 197
Query: 211 RNADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAI 270
+ ADI++ A G P + DMV P A +ID GI+ + +GK +VGD +++ + I
Sbjct: 198 KTADIVVVAIGKPDFLTKDMVNPNAFVIDAGISVV---DGK--VVGDA-AKDLQEYVKYI 251
Query: 271 TPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
TPVP GVG +TVAM+ N + + N+
Sbjct: 252 TPVPNGVGRLTVAMIFKNLMDLVKEKYNE 280
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 147 bits (356), Expect = 3e-34
Identities = 76/182 (41%), Positives = 114/182 (62%), Gaps = 2/182 (1%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++DGK +A I+ ELK ++ + + N P + ++VG+ S TYVR+K +A VG
Sbjct: 62 AALIDGKKIAETIRGELKVEVDELRAQYNTVPGLAVVLVGERKDSQTYVRSKKKACDEVG 121
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I++ + TEE++L+ + N+D +V GILVQLP+P+ INE+RV DAI+ EKD+DG
Sbjct: 122 INSFGADLPETATEEEVLAVVAKFNDDPNVHGILVQLPLPEHINEKRVLDAISLEKDVDG 181
Query: 122 FHIINIGRLCV--DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
FH NIG L + PT V T +E+LKR + G+ A V+GRS VG+P A++L
Sbjct: 182 FHPNNIGELAMRGRSPTYVSCTPKGCLELLKRAGVTLAGKRAAVVGRSNIVGLPAALLLQ 241
Query: 180 SD 181
+
Sbjct: 242 QE 243
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 144 bits (349), Expect = 2e-33
Identities = 91/297 (30%), Positives = 158/297 (53%), Gaps = 27/297 (9%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
I+ G +A EI+++LK+K + +P + I+VG YV K +AA G
Sbjct: 3 IISGSQIAQEIRQKLKEKNER----EGISPCLAMILVGGQKEDLHYVGLKEKAATATGGK 58
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINER--RVCDAIAPEKDIDG 121
+ ++ D ++++L+++I LN+D VDGIL+QLP+P + E+ + AI P+KD+DG
Sbjct: 59 SRLLHLPEDTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVDG 118
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
F ++N GR+ D P + ALA +E+++RF G+ AV++G S ++ +P+A ++
Sbjct: 119 FSLVNRGRMSGDRPGFISCAALACLEVIERFFPSLAGKKAVLVGDSFDLIIPLATIM--- 175
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
+ +++ Y P ADI++ G +++A+ + PG IID G
Sbjct: 176 ------IKRACQLSVLPSYEP-----GLASGADILVVEKGRAGIVQAEGLAPGVLIIDAG 224
Query: 242 ITRITDENGKSRLVGDVDYEEVSK--IAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
G + G+VD + + + PVPGG+GP+ +A LM N QAA+ +
Sbjct: 225 FYW-----GAGGVCGNVDRAALERQGFEARLLPVPGGMGPILIAKLMENLAQAARQK 276
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 140 bits (340), Expect = 3e-32
Identities = 74/179 (41%), Positives = 114/179 (63%), Gaps = 4/179 (2%)
Query: 2 ARILDGKALAMEIKKELKQKI-AQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
A+I+ G A+A I++EL+ ++ A L + P +R + VG S+ Y+R K++AA +
Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVP-DT-INERRVCDAIAPEKD 118
GIDA + ITE +LL +I +LNED V GI+VQ+P+ DT I+ R+ DA++PEKD
Sbjct: 64 GIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKD 123
Query: 119 IDGFHIINIGRLCV-DLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAM 176
+DG H +N GRL + DL +P T +E+++R ++ G AVV+GRSK VG P ++
Sbjct: 124 VDGLHTVNEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPASL 182
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 140 bits (340), Expect = 3e-32
Identities = 95/288 (32%), Positives = 147/288 (51%), Gaps = 20/288 (6%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
ILDGK L+ + LK+K+ Q+ P + VG+ +S+ Y++ K++ A +G+
Sbjct: 3 ILDGKKLSQKDTIFLKEKVNQF----KIKPVFTIVQVGNLFSSNKYIKTKMDKALEIGVV 58
Query: 64 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
+ I I+E+ L+S I+ E G++VQLP+P ++ ++ +++ KDIDG
Sbjct: 59 SRLIKIPESISEKDLISIIEE--ESKISHGLIVQLPLPLQFDQSKILNSVPITKDIDGLS 116
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKR 183
N L I PATA +++++K +N + VIG S VG PI +
Sbjct: 117 EKNSKNLYSGKSCIQPATARGIIDLIKEYNFTIKDKKVYVIGESNLVGKPIKELF----- 171
Query: 184 HESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGIT 243
++G I + ++ ADI+I A G P L+K + VK + +IDVGI
Sbjct: 172 KQAG-------AIVKSFNINTGIKG-SEEADILIVAAGHPNLVKPENVKNNSIVIDVGIN 223
Query: 244 RITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQ 291
I EN K + GDVD+ V AI+PVPGGVGPMTV L N +
Sbjct: 224 SI-GENDKMIVTGDVDFSNVKTKVKAISPVPGGVGPMTVISLFKNLIE 270
>UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus gnavus ATCC 29149|Rep: Putative
uncharacterized protein - Ruminococcus gnavus ATCC 29149
Length = 276
Score = 137 bits (331), Expect = 4e-31
Identities = 101/288 (35%), Positives = 149/288 (51%), Gaps = 31/288 (10%)
Query: 15 KKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDIT 74
KKELK++I ++ P + I + DD AS++Y++ K + +GI+ +N S+ T
Sbjct: 16 KKELKEEIKHL----DKKPVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNIYSNTT 71
Query: 75 EEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDL 134
E++ + + + DGI++QLP+PD N R+ I PEKD+DGF + C
Sbjct: 72 EQKEVECVITDIAKSDADGIIIQLPIPDKYNLERLQHLIPPEKDVDGFRKDS----C--- 124
Query: 135 PTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATV 194
P T +++ ++ N + G++ V+GRSK VG+P+ ML E G ATV
Sbjct: 125 --FKPCTPKGIIDWMEYNNFEFEGKDCCVLGRSKIVGLPLTNML-----IEKG----ATV 173
Query: 195 TICHRYTPKDKLEAYCRNADIIITATGLPKLIK-ADMVKPGATIIDVGITRITDENGKSR 253
T C+ TP Y RNAD +A G+P +D ++D+GI R DENGK
Sbjct: 174 TCCNSTTPSTWY--YTRNADYAFSAVGVPNYFDFSDFQDFCELVVDIGINR--DENGK-- 227
Query: 254 LVGDVDYE--EVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
L GDV+ E S +TPVPGGVG +T LM N A + Q K
Sbjct: 228 LCGDVNNAGFESSLNDTYVTPVPGGVGLLTRLTLMQNVVDAYKVQKMK 275
>UniRef50_UPI0000D9A063 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Macaca mulatta|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Macaca mulatta
Length = 198
Score = 125 bits (302), Expect = 1e-27
Identities = 64/155 (41%), Positives = 96/155 (61%), Gaps = 1/155 (0%)
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRF 152
G LVQLP+ +ER++C+A +P+K +D F ++N+G C+D +++ AT V E +K+
Sbjct: 31 GHLVQLPLAGHTDERKICNAFSPDKGVDDFPVMNVGLKCLDQYSMLLATRWDVRETIKQT 90
Query: 153 NIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRN 212
++ + VV GRSK V MPI M LH D HE DATV I Y+P ++L+ +
Sbjct: 91 DVPILEKTVVVAGRSKIVRMPIVMSLHIDGAHERPRD-DATVIISPGYSPNEQLKKHKIF 149
Query: 213 ADIIITATGLPKLIKADMVKPGATIIDVGITRITD 247
AD + +A G+P L D++K A +IDVGITR+ D
Sbjct: 150 ADSVTSAAGIPSLFTIDIIKERAAVIDVGITRVQD 184
>UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121;
n=5; Eutheria|Rep: Uncharacterized protein
ENSP00000372121 - Homo sapiens (Human)
Length = 200
Score = 124 bits (298), Expect = 4e-27
Identities = 61/104 (58%), Positives = 77/104 (74%), Gaps = 1/104 (0%)
Query: 187 GLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITRIT 246
G+ DATVTI +RYT K++L+ + ADI+I+A G+P LI ADM+K A + D+GI R+
Sbjct: 96 GINSDATVTISYRYTSKEQLKKHTILADIVISAAGIPNLITADMIKEEAAVTDMGINRVH 155
Query: 247 DE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNT 289
D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT
Sbjct: 156 DPVTAKLKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNT 199
Score = 65.3 bits (152), Expect = 2e-09
Identities = 27/63 (42%), Positives = 46/63 (73%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA +IK+E++Q++ +WV+ G++ P + I+VG+ ASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGDKRPHLSMILVGESSASHSYVLNKTRAAADVG 96
Query: 62 IDA 64
I++
Sbjct: 97 INS 99
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 121 bits (291), Expect = 3e-26
Identities = 94/316 (29%), Positives = 161/316 (50%), Gaps = 37/316 (11%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPAS----HTYVRNKVEA 56
M + G+ L K+ + + + +G P + +++ DDP +V K
Sbjct: 1 MVTWIRGEELHARTKEWARSHVKRLEEVGI-TPKLAVLLLNDDPVELETQRRFVTLKARD 59
Query: 57 AKFVGIDALTINRDSDITE---EQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAI 113
+ +G + S E ++ L I++LN + V G+++Q P+P ++E+ + A+
Sbjct: 60 VREIGGEVEIYELYSAPPERRTKEALRLIESLNRRDDVTGVIIQKPLPPFVDEKALFSAL 119
Query: 114 APEKDIDGFHIINIGRLCVDLPT---IVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNV 170
+PEKD+D N RL D ++P T ++E+ K + ID G++ VV+G+ + V
Sbjct: 120 SPEKDVDALTPENKKRLLTDFDLDRDVLPCTPAGILELFKLYGIDVRGKDVVVVGKGELV 179
Query: 171 GMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLP-KLIK-- 227
G P+A+ML + +DATVT+ H + K++ E Y + ADI+I+A G P +L K
Sbjct: 180 GKPLAVML---------MQLDATVTVLHALS-KER-EPYVKRADIVISAVGRPPELYKDN 228
Query: 228 -----ADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTV 282
DM+K GA ++ VG ++ + R DVD + V++ A +TP GGVG T
Sbjct: 229 PWRLTGDMIKEGAVVVGVG-GKV--DPATKRWFFDVDEKSVAEKASYLTPNIGGVGLATR 285
Query: 283 AMLMHN----TFQAAQ 294
A ++ N T+Q AQ
Sbjct: 286 ARVLKNLIRTTYQVAQ 301
>UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma pulmonis|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma pulmonis
Length = 272
Score = 119 bits (286), Expect = 1e-25
Identities = 85/292 (29%), Positives = 152/292 (52%), Gaps = 28/292 (9%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
M ++L + + ++ + ELK+K ++ ++ +++GD+ +S YV+ K+E A+ +
Sbjct: 2 MKKLLSNELVQIK-RAELKEKFSKL----DQKVKFAIVLIGDNASSKIYVKKKIEFAQDI 56
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPD-TINERRVCDAIAPEKDI 119
G++A + + ++ L + + D DGI++QLPV +NE + I KD+
Sbjct: 57 GVEAKLFHFEENVDFNLLKDAFKKI--DKEYDGIILQLPVLHFDVNELLLM--IDKNKDL 112
Query: 120 DGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLH 179
DG + N + I+PATA A+ LK I + V+G+S+ VG PI+ L
Sbjct: 113 DGLNPENEKAFYENRECIIPATARAIWTFLKFHKISVENKKVFVVGQSRLVGKPISQFLK 172
Query: 180 SDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIID 239
++ +A V + + T E ADI+I ATG+ +LIKA+ +K + +ID
Sbjct: 173 NN---------NAIVRVFDKSTGLKGTE----EADILIVATGVAQLIKAENIKENSILID 219
Query: 240 VGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQ 291
VG ++I +++ GD+D E + + A TP G +GP+TV L N ++
Sbjct: 220 VGFSKI-----NNKIYGDLDIESIKEKALKYTPPIGAIGPVTVLSLFENLYE 266
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 119 bits (286), Expect = 1e-25
Identities = 87/294 (29%), Positives = 146/294 (49%), Gaps = 22/294 (7%)
Query: 7 GKALAMEIKKELKQKIAQWVSLGNR-APTIRCIIVGDDPASHTYVRNKVEAAKFVGIDAL 65
GK LA + + ++ + W L P + ++ DD AS YV++K + AK +G+
Sbjct: 17 GKPLADRVMRGVRADLKAWAQLDPPFEPQLVSVLASDDEASQVYVQSKAKRAKKLGVAFR 76
Query: 66 TINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHII 125
++ + T+E L ++ L+ D +V GI+++LP+ ++ IA KDI+G
Sbjct: 77 VVDLGAAATQEALEQTLRELSADPAVHGIVLELPLAAGLDADAALLHIAARKDIEGLSPA 136
Query: 126 NIGRLCV--DLPTIVPATALAVVEMLKR-FNIDTFGRNAVVIGRSKNVGMPIAMMLHSDK 182
N+ + + ++P T +V +L+ D G VIG + VG P+ ML++
Sbjct: 137 NLALIAAGREPEALLPPTPRSVRFLLRHALGDDLRGLRVAVIGPGRTVGRPLLFMLNN-- 194
Query: 183 RHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGI 242
ATVT+C+ +T +D L A D ++ A G L++ + V+P +ID GI
Sbjct: 195 -------KGATVTLCNEHT-RD-LAAVLAAQDAVVVAVGKAGLLRPEQVQPEHVVIDAGI 245
Query: 243 TRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
E+G +VGD E + A TPVPGGVGP+T A++ N + + Q
Sbjct: 246 N--VQESGD--MVGDALPELPVR---AQTPVPGGVGPLTSALMYQNLVRGVKLQ 292
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 114 bits (275), Expect = 2e-24
Identities = 79/251 (31%), Positives = 130/251 (51%), Gaps = 22/251 (8%)
Query: 38 IIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQ 97
I DD +S ++++ K+ A VG + I + IT+ +L+ +I +LN D +V GI++Q
Sbjct: 29 IQANDDDSSDSFIKQKLIACNTVGAKSELIKLSNQITQAELIEKIISLNHDVNVTGIILQ 88
Query: 98 LPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTF 157
LPV +++ + +AI P KD+DG + L I P A++ + + FN++
Sbjct: 89 LPVYPHLDKNSLLEAINPLKDVDGLTTNH-------LAEIKPCIVEAIITLKELFNLEFN 141
Query: 158 GRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIII 217
+ VV+G G PI L + SG + A C + TP + E ++ADI+
Sbjct: 142 NQKIVVVGLGITGGKPIYEFLKT-----SGYKVQA----CDKDTP-NTFE-LIKSADIVF 190
Query: 218 TATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGV 277
TA G +A K G + D+G++R N +++L GD++ E + K A T PGGV
Sbjct: 191 TAIGKSHFFQAKNFKKGVILFDIGVSR----NKQNKLCGDINPEGIEKKARWWTKTPGGV 246
Query: 278 GPMTVAMLMHN 288
GP TV ++ N
Sbjct: 247 GPFTVLAIIKN 257
>UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Mycoplasma gallisepticum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma gallisepticum
Length = 283
Score = 112 bits (270), Expect = 9e-24
Identities = 78/293 (26%), Positives = 133/293 (45%), Gaps = 19/293 (6%)
Query: 5 LDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 64
LDG L+ ++K++L +K+ N+ I II AS YVRNK+ +GI
Sbjct: 5 LDGTKLSQKLKEDLAKKV------NNQKIKILIIISDPSEASRIYVRNKINYCDSLGIQT 58
Query: 65 LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHI 124
+ Q + E+ ++ +G+LVQLP+ + ++ ++ + I D+D F
Sbjct: 59 EVYDLSKIDDTNQFIVEMNQKISLSNPNGVLVQLPIKERLDTNKIIENIPIRLDVDAFLY 118
Query: 125 INIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRH 184
+ ++P AV+E+ K + + + ++IG PI L+
Sbjct: 119 HRFDQ--DQKEKVIPCVLNAVLELFKEYQLSFLDKKILLIGNGITSNQPIVNYLN----- 171
Query: 185 ESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITR 244
E + D LE + AD++I+A G K + K G ID+GI +
Sbjct: 172 EHQIKFDLITK-----ENSQLLEEKTKVADLVISAVGKAKFLANYQFKRGVIFIDIGIDK 226
Query: 245 ITD-ENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQ 296
D E K + GD DY+++ +IA TP PGG+GP+T+ L+ N ++ Q
Sbjct: 227 YFDPEQSKYLICGDFDYDKLKEIASYGTPTPGGIGPLTIYSLVKNLINLSEIQ 279
>UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein, putative; n=1; Trypanosoma
cruzi|Rep: Methylenetetrahydrofolate dehydrogenase-like
protein, putative - Trypanosoma cruzi
Length = 375
Score = 105 bits (251), Expect = 2e-21
Identities = 57/147 (38%), Positives = 83/147 (56%), Gaps = 13/147 (8%)
Query: 160 NAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITA 219
+AV+I +S VG+P A +L + VT+C R + ++ R AD+++TA
Sbjct: 196 HAVIINKSMVVGVPTAALLQKEDNF--------LVTLCSRSNDLEAVKEVSRQADVLVTA 247
Query: 220 TGLPKLIKADMVKPGATIIDVGITRITDENGKS-----RLVGDVDYEEVSKIAGAITPVP 274
G+P+++ AD VKPGA ++DV I G+ R+ GDVD V + A A+TPVP
Sbjct: 248 LGIPRVVTADFVKPGAIVLDVAINEDCASGGEMTSGSRRVCGDVDLASVREKAAAVTPVP 307
Query: 275 GGVGPMTVAMLMHNTFQAAQSQANKSN 301
GG+GP+TVA LM NT +A N N
Sbjct: 308 GGIGPLTVAYLMQNTLKAHLLAKNHIN 334
Score = 79.0 bits (186), Expect = 1e-13
Identities = 42/132 (31%), Positives = 76/132 (57%), Gaps = 4/132 (3%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A IL G+ L+ + + ++ ++A+ + +P++ ++VG+ S YV K A+ G
Sbjct: 3 AEILLGRPLSGTLIERIQHEVARL----SCSPSLAVVMVGNRQDSRRYVSVKQRTAEACG 58
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I ++ ++EE+L E++ +++DN+ DG+L+QLP+P + R I P KD+DG
Sbjct: 59 IRFHLLSLPETVSEERLHQELRRISDDNAFDGVLLQLPIPSHLRVRPALLCIHPGKDVDG 118
Query: 122 FHIINIGRLCVD 133
H IN G L +D
Sbjct: 119 LHPINAGSLFLD 130
>UniRef50_UPI00005A5066 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Canis lupus
familiaris|Rep: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Canis familiaris
Length = 239
Score = 101 bits (241), Expect = 3e-20
Identities = 53/100 (53%), Positives = 72/100 (72%), Gaps = 2/100 (2%)
Query: 196 ICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITRITDE-NGKSRL 254
+ H+YTPK++L+ A+I+I+A G+ LI AD++K GA +I+VGI R+ D K++L
Sbjct: 98 LSHQYTPKEQLKKCTVLAEIVISAVGILNLITADIIKEGAALINVGINRVQDPILSKAKL 157
Query: 255 VGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
VGDVD+E + K A ITPV GVGPMTVAMLM NT AA+
Sbjct: 158 VGDVDFEGIRKNANYITPV-WGVGPMTVAMLMKNTIIAAK 196
>UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein; n=2; Leishmania|Rep:
Methylenetetrahydrofolate dehydrogenase-like protein -
Leishmania major
Length = 207
Score = 75.4 bits (177), Expect = 2e-12
Identities = 39/115 (33%), Positives = 63/115 (54%)
Query: 14 IKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDI 73
I K+L+Q+I S+ R P + ++VGD S YV +K+ AA GI+ ++ + +
Sbjct: 40 ISKQLRQRIRASTSVLRRPPCLVVVLVGDGADSIHYVNHKMRAAADCGIEVRLVHLSATV 99
Query: 74 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIG 128
+ +L + +N+D VD +L+QLP+P R I P KD+DG H +N G
Sbjct: 100 QQIELHRTLAAVNDDVEVDAVLLQLPLPPHQRTRSALVHIHPGKDVDGLHPLNAG 154
>UniRef50_A1ZUI3 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Microscilla marina ATCC 23134|Rep: Tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Microscilla marina ATCC 23134
Length = 233
Score = 71.7 bits (168), Expect = 2e-11
Identities = 64/208 (30%), Positives = 101/208 (48%), Gaps = 17/208 (8%)
Query: 82 IQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPAT 141
I +LN+D ++ ++VQ P P + + + P+KD+D R+ P PAT
Sbjct: 2 IDSLNKDTNIGAVIVQSPPPKGLEN--IVKKLNPKKDLDALSGDKKNRM---FP--YPAT 54
Query: 142 ALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYT 201
+ +V +++ F G+ VV+G +G + ML +K + + +D V Y
Sbjct: 55 SEGIVRIVEPFA--EAGKKIVVVGGGGFIGEGVITML-KEKGIKPHI-IDPRVIDDPGYQ 110
Query: 202 PKDKLEAYCRNADIIITATGLPKLIKADMVKPGAT-IIDVGITRI--TDENGKSRLVGDV 258
KD A +N DIII+ G LIK +K T I+D G + D+ + GDV
Sbjct: 111 GKDL--ALMKNYDIIISTVGKEGLIKGKDLKDDHTLIVDTGFVPLENVDKLTSKNVKGDV 168
Query: 259 DYEEVSKIAGAITPVPGGVGPMTVAMLM 286
D +K +TPVPGG GP+ +A+LM
Sbjct: 169 DPTAKNKTK-FVTPVPGGTGPVEMAVLM 195
>UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=1; Chlorobaculum tepidum|Rep:
Methylenetetrahydrofolate dehydrogenase - Chlorobium
tepidum
Length = 296
Score = 71.3 bits (167), Expect = 3e-11
Identities = 73/276 (26%), Positives = 125/276 (45%), Gaps = 43/276 (15%)
Query: 38 IIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQ 97
I+ DDPAS TY + VGI + + E + + ++ N D++V GI V
Sbjct: 33 ILASDDPASITYADYTRAGCEDVGIH-FDLRK---CEPESVRATLEAANRDSAVHGIFVY 88
Query: 98 LPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD---------LPTIVPATALAVVEM 148
P+ + + D I+P KD++G I +L + +I+P T LA++++
Sbjct: 89 YPIWGDKRDAELRDLISPHKDVEGLSPHWIKKLYANERFDDTERRFKSILPCTPLAIIKL 148
Query: 149 LK------RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTI-----C 197
L+ F + G+ + RS+ VG P+A ML +D ++ +
Sbjct: 149 LEVTEAYAPFGLPFGGQQITIFNRSEVVGRPLAYMLSNDGARVYSFDINGGFVVDVNSSD 208
Query: 198 HRYTPKDKLEAYCRNADIIITATGLP--KLIKADMVKPGATIIDVGITRITDENGKSRLV 255
H P + EA + +DI+IT P + ++A+ +KPGA ++ +
Sbjct: 209 HESRPVTREEALSQ-SDIVITGVPSPHFEKVRAEELKPGAICLNFSYIQ----------- 256
Query: 256 GDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQ 291
++E +K A ++ +P VGPMTVAM M N Q
Sbjct: 257 ---NFEPEAKEAASLY-IP-RVGPMTVAMCMRNALQ 287
>UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to
Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor;
n=2; Catarrhini|Rep: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Macaca mulatta
Length = 111
Score = 70.1 bits (164), Expect = 6e-11
Identities = 29/61 (47%), Positives = 46/61 (75%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA EIK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQEIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAADVG 96
Query: 62 I 62
+
Sbjct: 97 M 97
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 65.3 bits (152), Expect = 2e-09
Identities = 56/219 (25%), Positives = 102/219 (46%), Gaps = 18/219 (8%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P++ I G+D NK + A+ +G++ I + +E ++++E+ L+ED V
Sbjct: 23 PSLAIIQAGEDDGLLEI--NK-KMARRIGLNVTQICLAKECSEIEIVTEVLKLSEDPGVH 79
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC-VDLPT-IVPATALAVVEMLK 150
G+ + LP + RV A+ PEKD+DG +N G L DL VP AV+E L
Sbjct: 80 GLYLHLPQASLTS--RVLTALKPEKDVDGLSDLNTGCLIRGDLSAGFVPPVTSAVLEWLS 137
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
+ ++ G+ +++G + + ++ G++ V+ +T K+ L++
Sbjct: 138 KHHVTLEGKTVLILGGHGTFEVTLRCLIERQ-------GIEVVVS---DWTSKN-LKSQV 186
Query: 211 RNADIIITATGLPKLIKADMVKPGATIIDVGITRITDEN 249
AD ++ K + KPGA + T TDE+
Sbjct: 187 MRADAVVVLEAGKKNLPPTWFKPGALVFSCDPTSKTDES 225
>UniRef50_UPI00015563B5 Cluster: PREDICTED: similar to Mthfd2-prov
protein, partial; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to Mthfd2-prov protein, partial -
Ornithorhynchus anatinus
Length = 161
Score = 62.9 bits (146), Expect = 1e-08
Identities = 24/56 (42%), Positives = 43/56 (76%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAA 57
A ++ G+ LA +I++E++ ++ +WV+ GN+ P + I+VG++PASH+YV NK +AA
Sbjct: 47 AVVISGRKLARQIREEVRHEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTKAA 102
>UniRef50_UPI000023D48A Cluster: hypothetical protein FG10624.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG10624.1 - Gibberella zeae PH-1
Length = 302
Score = 62.9 bits (146), Expect = 1e-08
Identities = 69/292 (23%), Positives = 131/292 (44%), Gaps = 38/292 (13%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
AR+L G + +I++ +K + G P + + + YV+ K A G
Sbjct: 18 ARLLTGDLVVRDIERWCDRKADK----GGVKPVMAVVYFNTGADAIDYVKIKAHVAARAG 73
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
+ D + Q++++++ LN++ + GIL+Q P+P +NE V +I P K+I+
Sbjct: 74 VSYWVYEMPVDASTTQVMTQVKKLNKNPRIHGILIQRPLPRQLNEPEVMRSINPIKNIEE 133
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
+ + D A+V +L ++ + R + R + VG +
Sbjct: 134 YAKGRANNIAAD----------ALVRLLTKYGL----RESAQQARIQIVGFGNIITKEFI 179
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATI-IDV 240
K+ +S P ++EA R++ II P IK+ MVK ++ +D+
Sbjct: 180 KQMKSQF-------------PYMEVEA-PRDSIIISELHRGPGFIKSSMVKSEVSVLVDL 225
Query: 241 GITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQA 292
G +T++ ++GDV + + + AI P PGGV P+ + ++M T +A
Sbjct: 226 GF-YVTEKG----VLGDVSHVLFDRSSLAIAPTPGGVLPILLWIMMERTIKA 272
>UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate
formyltetrahydrofolate synthetase domain containing 1;
n=1; Danio rerio|Rep: Novel protein similar to
vertebrate formyltetrahydrofolate synthetase domain
containing 1 - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 217
Score = 62.5 bits (145), Expect = 1e-08
Identities = 41/124 (33%), Positives = 66/124 (53%), Gaps = 7/124 (5%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
PT+ I G+D NK A K +G++ + I TEE+++ E+ LN+D+ V
Sbjct: 22 PTLAIIQAGEDDG--LLEMNKKMAGK-IGLNVMQICLPHRCTEEEVIEEVLRLNKDSRVH 78
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT--IVPATALAVVEMLK 150
GI + L P T + V +AI P+KD+DG +N+GR+ + T A AV+E+L
Sbjct: 79 GIFLHL--PQTFLSKSVRNAIKPQKDVDGVCDLNVGRVVLGDKTDGFTSPVAGAVLELLA 136
Query: 151 RFNI 154
+ +
Sbjct: 137 KHGV 140
>UniRef50_Q02046 Cluster: Methylenetetrahydrofolate dehydrogenase
[NAD+]; n=27; Ascomycota|Rep: Methylenetetrahydrofolate
dehydrogenase [NAD+] - Saccharomyces cerevisiae (Baker's
yeast)
Length = 320
Score = 59.7 bits (138), Expect = 9e-08
Identities = 52/199 (26%), Positives = 94/199 (47%), Gaps = 24/199 (12%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGN-RAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
R + +A E+ + ++ N + P + + +DPA+ Y + ++ +G
Sbjct: 6 RTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMG 65
Query: 62 IDA-LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 120
L + D D EE ++ N D+SV+GI+V PV ++ + + EKD++
Sbjct: 66 FRYDLRVIEDKDFLEEAIIQA----NGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVE 121
Query: 121 GFHII-------NIGRLCVD--LPTIVPATALAVV---EMLKRFN------IDTFGRNAV 162
G + + N+ L + L +I+P T LA+V E LK +N +G+ +
Sbjct: 122 GLNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCI 181
Query: 163 VIGRSKNVGMPIAMMLHSD 181
VI RS+ VG P+A +L +D
Sbjct: 182 VINRSEIVGRPLAALLAND 200
>UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=2; Dictyostelium discoideum|Rep:
Methylenetetrahydrofolate dehydrogenase - Dictyostelium
discoideum AX4
Length = 313
Score = 53.2 bits (122), Expect = 8e-06
Identities = 64/272 (23%), Positives = 119/272 (43%), Gaps = 34/272 (12%)
Query: 7 GKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALT 66
GK I ++++ Q ++ P + + DD + Y + A + GI+ +
Sbjct: 13 GKVDVTPIANFFREEVKQQITKNCWKPRVVAFLTSDDQGAIDYSKWTKLACQKDGIEFI- 71
Query: 67 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG----- 121
+ R + E L+ E N D+ V GILV PV + + + D ++P KDI+G
Sbjct: 72 LKRVERVDLEDLIIEANN---DSCVHGILVYYPVFGGMMDSYLQDVVSPTKDIEGLSTQN 128
Query: 122 -FHII-NIGRLCVDLPT---IVPATALAVVEMLKRFNI---------DTFGRNAVVIGRS 167
F++ NI + + T ++P T LA+V+++ I G+ ++ RS
Sbjct: 129 RFNLYHNIRFMDGETATKKCVIPCTPLAMVKIIDNLGIYDKSLAMGEHLKGKTVTIVNRS 188
Query: 168 KNVGMPIAMMLHSDKRHESGLGMDATV---------TICHRYTPKDKLEAYCRNADIIIT 218
+ VG P+A ML +D + ++ + TI T + EA + +DI+I
Sbjct: 189 EIVGRPLAAMLANDGAIVYSIDINGIIIFQSGKRHGTIKMSETNVTREEAISK-SDILIL 247
Query: 219 ATGLPKL-IKADMVKPGATIIDVGITRITDEN 249
P + +D+++ G +I+ DE+
Sbjct: 248 GVPSPNYKVNSDLIQDGTIVINFAGCLNVDES 279
>UniRef50_Q4VDG8 Cluster: Putative methylene tetrahydrofolate
dehydrogenase; n=1; Hyaloperonospora parasitica|Rep:
Putative methylene tetrahydrofolate dehydrogenase -
Hyaloperonospora parasitica
Length = 328
Score = 50.8 bits (116), Expect = 4e-05
Identities = 67/295 (22%), Positives = 120/295 (40%), Gaps = 35/295 (11%)
Query: 5 LDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 64
+D +A ++Q I + P + ++ DPA+ Y +A GI
Sbjct: 19 VDASTIAEPFSSAVRQYIEH--DMAGVGPKLIGLLAHGDPAAKKYAEWTGKACARDGIRY 76
Query: 65 LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI-------NERRVCDAIAPEK 117
++ ++ LL+ +Q NED V GILV P T + + D+I+ +K
Sbjct: 77 EL----REVPKDDLLAALQQANEDPDVHGILVYYPCFGTFPSFFGGTMDDFLRDSISIKK 132
Query: 118 DIDGFHIINIGRLCVDL---------PTIVPATALAVVEMLKRFNI----------DTFG 158
D++G G L ++ ++P T LA+V++L+ I G
Sbjct: 133 DVEGLGQFYRGNLYRNIRYVDDEKTQKCVLPCTPLAIVKILEHLGIYDKARENTGNQLEG 192
Query: 159 RNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICH-RYTPKDKL-EAYCRNADII 216
+ VI RS VG P+A +L +D +D+ + P ++ E C+ + +I
Sbjct: 193 VSITVINRSDIVGRPLAALLANDGADVYSADIDSLYLFRRGKLIPSEETPETACKKSRVI 252
Query: 217 ITATGLPKL-IKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAI 270
IT + + + V +I+V + DE G ++ G V K+ A+
Sbjct: 253 ITGVPVKSYKLSLEWVSENTIVINVASFKNVDEAGLLQIKGVQYVPLVGKVTVAM 307
>UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1;
Treponema primitia|Rep: Methylene-THF dehydrogenase -
Treponema primitia
Length = 97
Score = 49.6 bits (113), Expect = 1e-04
Identities = 30/97 (30%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
MA++LDGK +A + + LK+ + + G PT+ I +G+ +Y + + A+ V
Sbjct: 1 MAQLLDGKVVAAALAESLKKDVEALKAKGV-TPTLGIIRLGEKGPDISYEKGATKRAEEV 59
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQ 97
G D T+E LL I+ N+D V G L Q
Sbjct: 60 GAAVKNYILPEDTTQEALLKVIKEANDDKGVHGCLAQ 96
>UniRef50_A6QZK7 Cluster: Putative uncharacterized protein; n=1;
Ajellomyces capsulatus NAm1|Rep: Putative
uncharacterized protein - Ajellomyces capsulatus NAm1
Length = 297
Score = 46.4 bits (105), Expect = 0.001
Identities = 50/193 (25%), Positives = 89/193 (46%), Gaps = 27/193 (13%)
Query: 10 LAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI--DALTI 67
LA + + L ++ + + AP + + DPA+ Y + K T+
Sbjct: 17 LAANVARGLLAEVNEGRQTLSTAPHLVGFLANSDPAAKMYADWTEKTCKDNNFRYTLRTV 76
Query: 68 NRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF---HI 124
+RD DI + L++ N D VDGI+V P+ + ++ + + KD++G +I
Sbjct: 77 SRD-DIEDAILVA-----NSDPDVDGIIVYYPIFNNRQDQYLQQIVDISKDVEGLSHRYI 130
Query: 125 INIGRLC--VDLP-----TIVPATALAVVEMLKRFNIDT---------FGRNAVVIGRSK 168
N+ + +D P +I+P T LAV+++L+ I FG V+ RS+
Sbjct: 131 FNMYQNIRFLDPPENKQKSILPCTPLAVIKILEYLQIYNTILPYGNRLFGHTICVVNRSE 190
Query: 169 NVGMPIAMMLHSD 181
VG P+A +L +D
Sbjct: 191 VVGRPLAALLAND 203
>UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergillus
oryzae|Rep: RIB40 genomic DNA, SC009 - Aspergillus
oryzae
Length = 275
Score = 44.0 bits (99), Expect = 0.005
Identities = 37/159 (23%), Positives = 74/159 (46%), Gaps = 22/159 (13%)
Query: 38 IIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQ 97
++ DD S+ Y + + +G+ + ++ + + + I+ +N +NSV GI+V
Sbjct: 38 VLASDDAGSNQYANWTRKTCQEIGVHFHLMK----LSPKNVATYIRAINANNSVHGIIVY 93
Query: 98 LPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC----VDLP-----TIVPATALAVVEM 148
P+ + + +AP KD++G + + R+ V P ++P T AV +
Sbjct: 94 YPIFGDRRDDEIRQLVAPSKDVEGLNHQTLHRISDAAEVSRPPKPGRNVIPCTPRAVAWI 153
Query: 149 LKRFNIDTFGRNA---------VVIGRSKNVGMPIAMML 178
L+ ++ R A +I RS+ VG+P+A +L
Sbjct: 154 LEWMDVHDRTRPAGERLQNQEICIINRSEVVGLPLAHLL 192
>UniRef50_Q9PQF4 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=1; Ureaplasma parvum|Rep: Methylenetetrahydrofolate
dehydrogenase - Ureaplasma parvum (Ureaplasma
urealyticum biotype 1)
Length = 269
Score = 43.6 bits (98), Expect = 0.006
Identities = 49/246 (19%), Positives = 108/246 (43%), Gaps = 21/246 (8%)
Query: 49 YVRNKVEAAKFVGIDALTINRDSDITEEQ--LLSEIQNLNEDNSVDGILVQLPVPDTINE 106
Y+++K++ AK + + + ++ +E LS+++ N+D + + P+ +
Sbjct: 42 YIQSKLKYAKLFSVKLIIYDLNAYQIQENHHFLSKLKQANKDF----LFFEFPLSKKHLD 97
Query: 107 RRVCDAIAPEKDIDGFHI-INIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIG 165
+ + + D+DG + + + + + PAT A++ ++K +++ +IG
Sbjct: 98 QNYFQYLTFQNDLDGINSHLFLNKKQENQIIYHPATINAILTLIKELDVNLNDYRICIIG 157
Query: 166 RSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKL 225
RS +G + +L+ + I H T K+ L + ++ II+ +
Sbjct: 158 RSPYLGDYLYKLLNPKNNK---------INIIHSQT-KNPLRII-KESNFIISCVNKAHI 206
Query: 226 IKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAML 285
++ + + +IDV I ++ S L+ D + TPVPGG+G +T L
Sbjct: 207 FNSNALSDNSYLIDVTTEYINNKLCGSFLINKNDALNRNI---KYTPVPGGIGKLTTLFL 263
Query: 286 MHNTFQ 291
N F+
Sbjct: 264 FLNYFK 269
>UniRef50_Q8ZSG1 Cluster: Alr7549 protein; n=3; Nostocaceae|Rep:
Alr7549 protein - Anabaena sp. (strain PCC 7120)
Length = 246
Score = 38.7 bits (86), Expect = 0.18
Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 45 ASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI 104
A+ KV +GI I ++I EQ + IQ++NE++ V +VQ P+P
Sbjct: 52 AARISAEQKVATFNAIGITPNYIALSANIAVEQFDNIIQSINENSKVTAAIVQYPIPAKF 111
Query: 105 NERRVCDAIAPEKDID 120
+ P+KDID
Sbjct: 112 TSS--IQLLEPQKDID 125
>UniRef50_Q08352 Cluster: Alanine dehydrogenase; n=81; Bacteria|Rep:
Alanine dehydrogenase - Bacillus subtilis
Length = 378
Score = 38.3 bits (85), Expect = 0.24
Identities = 48/210 (22%), Positives = 83/210 (39%), Gaps = 12/210 (5%)
Query: 102 DTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNA 161
+T++E R + P ++ G IG ++ P LA V + R + G
Sbjct: 117 ETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAGVPGVSRGKVTIIGGGV 176
Query: 162 VVIGRSK---NVGMPIAMM-LHSDKRHESG--LGMDATVTICHRYTPKDKL-EAYCRNAD 214
V +K +G + ++ L++D+ + G I + D + EA
Sbjct: 177 VGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLISNPVNIADAVAEADLLICA 236
Query: 215 IIITATGLPKLIKADMVK---PGATIIDVGITR--ITDENGKSRLVGDVDYEEVSKIAGA 269
++I P L+ +MVK PG+ I+DV I + I + YE+ + A
Sbjct: 237 VLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETVDHITTHDQPTYEKHGVVHYA 296
Query: 270 ITPVPGGVGPMTVAMLMHNTFQAAQSQANK 299
+ +PG V + L + T A ANK
Sbjct: 297 VANMPGAVPRTSTIALTNVTVPYALQIANK 326
>UniRef50_P11864 Cluster: Uncharacterized protein yhaC; n=7;
Enterobacteriaceae|Rep: Uncharacterized protein yhaC -
Escherichia coli (strain K12)
Length = 395
Score = 37.9 bits (84), Expect = 0.32
Identities = 39/113 (34%), Positives = 57/113 (50%), Gaps = 10/113 (8%)
Query: 8 KALAMEIKKELKQKIAQWVSLGNRA-PTIRCIIVGDDPASHTYVRN----KVEAAK--FV 60
+ALA I+K LKQ + V+L N P +CII GD Y++N V + + F+
Sbjct: 33 EALAPGIEK-LKQTSIEMVTLLNTLQPGGKCIITGDFQKELAYLQNVILYNVSSLRLDFL 91
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAI 113
G +A I R SD T E ++E N++ S I + P+ D NE R + I
Sbjct: 92 GYNAQIIQR-SDNTCELTINEPLK-NQEISTGNININCPLKDIYNEIRRLNVI 142
>UniRef50_P58339 Cluster: Ornithine cyclodeaminase 2; n=5;
Proteobacteria|Rep: Ornithine cyclodeaminase 2 -
Rhizobium meliloti (Sinorhizobium meliloti)
Length = 342
Score = 37.5 bits (83), Expect = 0.42
Identities = 21/43 (48%), Positives = 27/43 (62%), Gaps = 5/43 (11%)
Query: 213 ADIIITAT-GLPKLIKADMVKPGATIIDVGITRITDENGKSRL 254
ADI+IT T G L++AD VKPG I+ +G TD+ GK L
Sbjct: 209 ADILITTTRGKGSLVEADWVKPGTHIVAIG----TDQRGKQEL 247
>UniRef50_A0FRY0 Cluster: Aminotransferase class-III; n=1;
Burkholderia phymatum STM815|Rep: Aminotransferase
class-III - Burkholderia phymatum STM815
Length = 955
Score = 37.1 bits (82), Expect = 0.55
Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 7/66 (10%)
Query: 213 ADIIITATGLPK-LIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAIT 271
AD+I+TAT P+ + A++++PGA + D+ R + + +V I G I
Sbjct: 810 ADVIVTATSFPRNSVDANLLRPGAIVCDISRPRSLSASAA------LTRPDVLVIDGGIV 863
Query: 272 PVPGGV 277
VPGGV
Sbjct: 864 SVPGGV 869
>UniRef50_A5K2D8 Cluster: Putative uncharacterized protein; n=1;
Plasmodium vivax|Rep: Putative uncharacterized protein -
Plasmodium vivax
Length = 614
Score = 37.1 bits (82), Expect = 0.55
Identities = 16/35 (45%), Positives = 23/35 (65%)
Query: 211 RNADIIITATGLPKLIKADMVKPGATIIDVGITRI 245
+ AD+II A G P L+K +K GA I+D+GI +
Sbjct: 392 KQADVIIIAIGCPHLLKKRNIKEGAIILDLGINLV 426
>UniRef50_A7IBV4 Cluster: Putative uncharacterized protein; n=1;
Xanthobacter autotrophicus Py2|Rep: Putative
uncharacterized protein - Xanthobacter sp. (strain Py2)
Length = 429
Score = 36.3 bits (80), Expect = 0.97
Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 216 IITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAITPVPG 275
++ G+ L+KA ++ GATI+ GI R+ E G V V + G I V G
Sbjct: 46 LVGGEGIMPLVKAGLLAAGATIVSYGINRLAVERGAPLAVVGYKSAAVLSVVG-ILAVGG 104
Query: 276 GVGPMTVAMLMHNTFQAAQSQAN 298
G+ T L++ + + +A+
Sbjct: 105 GLFGATYPGLVYRDVEQLRLEAH 127
>UniRef50_Q4YPQ5 Cluster: Putative uncharacterized protein; n=4;
Plasmodium (Vinckeia)|Rep: Putative uncharacterized
protein - Plasmodium berghei
Length = 666
Score = 35.9 bits (79), Expect = 1.3
Identities = 16/37 (43%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 254 LVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTF 290
+ GDVD K + I+ VPGG+GP+T +ML +N +
Sbjct: 613 IFGDVDLN-CRKNSSHISAVPGGIGPITTSMLFYNLY 648
>UniRef50_P76339 Cluster: Putative sensor-like histidine kinase
yedV; n=22; Enterobacteriaceae|Rep: Putative sensor-like
histidine kinase yedV - Escherichia coli (strain K12)
Length = 452
Score = 35.9 bits (79), Expect = 1.3
Identities = 25/93 (26%), Positives = 47/93 (50%), Gaps = 5/93 (5%)
Query: 68 NRDSDITEEQLLSEIQNLNE----DNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 123
NR D++++ L+ ++N+ N DG+L +P +TI+ + +I + +ID
Sbjct: 70 NRMMDVSQDILIIHGDSINKIVNRTNVSDGMLNNIPASETISAAGIYRSIINDTEIDALR 129
Query: 124 IINIGRLCVDLPTIVPATALAVVEMLKRFNIDT 156
INI + L V A A ML+++ I++
Sbjct: 130 -INIDEVSPSLTVTVAKLASARHNMLEQYKINS 161
>UniRef50_Q6LEW8 Cluster: Putative uncharacterized protein; n=1;
Plasmodium falciparum 3D7|Rep: Putative uncharacterized
protein - Plasmodium falciparum (isolate 3D7)
Length = 657
Score = 35.5 bits (78), Expect = 1.7
Identities = 16/37 (43%), Positives = 26/37 (70%), Gaps = 1/37 (2%)
Query: 254 LVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTF 290
++GDVD +K + I+ VPGG+GP+T +ML +N +
Sbjct: 619 IMGDVDMNCKNKCS-YISSVPGGLGPITTSMLFYNLY 654
Score = 33.5 bits (73), Expect = 6.8
Identities = 21/86 (24%), Positives = 47/86 (54%), Gaps = 3/86 (3%)
Query: 38 IIVGDDPASHTYVRNKVEAAKFVGIDAL--TINRDSDITEEQLLSEIQNLN-EDNSVDGI 94
II + S++Y+ ++ + ++ D + I + ++EE+L+ I+ +N +N+ +
Sbjct: 44 IIYSKNIVSYSYLYILLKKSIYLNSDVVFVLIRVNKKVSEEKLIKIIKRININENNDTSL 103
Query: 95 LVQLPVPDTINERRVCDAIAPEKDID 120
++ P+ IN+ + + I EKDID
Sbjct: 104 IILSPLSYHINKCYISEFIQKEKDID 129
>UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase
(NAD+), putative; n=1; Filobasidiella neoformans|Rep:
Methylenetetrahydrofolate dehydrogenase (NAD+), putative
- Cryptococcus neoformans (Filobasidiella neoformans)
Length = 367
Score = 34.7 bits (76), Expect = 3.0
Identities = 28/127 (22%), Positives = 55/127 (43%), Gaps = 8/127 (6%)
Query: 4 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 63
++ +A K EL +A +R P + I+ + TY +A + +GI
Sbjct: 6 LITASKVATPFKSELLSALAS-PRFSSRPPHLVGILATKKEDARTYAEFTKKACETLGIT 64
Query: 64 -ALTI------NRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPE 116
L + D + ++ I NED VDG++V P+ ++ + ++P+
Sbjct: 65 YELRLVGEAREGMDGEGVGIEVEEAILEANEDPEVDGMMVYYPIYGGRQDQYLQSVVSPQ 124
Query: 117 KDIDGFH 123
KD++G +
Sbjct: 125 KDVEGLN 131
>UniRef50_Q0UVW9 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 309
Score = 34.7 bits (76), Expect = 3.0
Identities = 37/172 (21%), Positives = 68/172 (39%), Gaps = 7/172 (4%)
Query: 10 LAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 69
LA I K L +++ +S R P + + DPA+ Y + G
Sbjct: 12 LANNIAKSLLEEVRDGLSKIERKPLLVGFLSSSDPAARVYAEWTGKTCTENGFAFDLREV 71
Query: 70 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGR 129
D ++ E+ L+ + N D+ + I + + ++ R + + + +D +
Sbjct: 72 DRELLEDALI----DANNDDKIVSIDKDV---EGLSHRYIFNMYQNIRFLDPANTKKSIL 124
Query: 130 LCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
C L I L + + + GR VI RS+ VG P+A +L +D
Sbjct: 125 PCTPLAVIKILEYLRIYNTILPYGNRLHGRTITVINRSEVVGRPLAALLAND 176
>UniRef50_UPI0000D56538 Cluster: PREDICTED: similar to activating
signal cointegrator 1 complex subunit 3 isoform a,
partial; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to activating signal cointegrator 1 complex
subunit 3 isoform a, partial - Tribolium castaneum
Length = 1407
Score = 34.3 bits (75), Expect = 3.9
Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 5/76 (6%)
Query: 201 TPKDKLEAYCRN--ADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDV 258
T KD+LE C N D + + +LIK+D+ KP +D+ I I + + G+V
Sbjct: 116 TVKDELEYVCDNLPGDFFKKGSEMARLIKSDVEKPAEKPLDI-IFYIPMSENEPCIEGEV 174
Query: 259 DYEEVSKIAGAITPVP 274
EE+S A A T P
Sbjct: 175 --EELSLAAAASTGAP 188
>UniRef50_Q83AZ8 Cluster: Ornithine cyclodeaminase; n=2; Coxiella
burnetii|Rep: Ornithine cyclodeaminase - Coxiella
burnetii
Length = 336
Score = 34.3 bits (75), Expect = 3.9
Identities = 21/52 (40%), Positives = 30/52 (57%), Gaps = 7/52 (13%)
Query: 206 LEAYCRNADIIITATGLPK---LIKADMVKPGATIIDVGITRITDENGKSRL 254
+E +NADII TAT + K ++K D ++PG TI +G D GK+ L
Sbjct: 187 VETAIKNADIITTATAIQKKTQILKNDWIQPGMTINAIG----GDRAGKTEL 234
>UniRef50_Q47IC2 Cluster: Putative uncharacterized protein; n=1;
Dechloromonas aromatica RCB|Rep: Putative
uncharacterized protein - Dechloromonas aromatica
(strain RCB)
Length = 133
Score = 34.3 bits (75), Expect = 3.9
Identities = 15/43 (34%), Positives = 23/43 (53%)
Query: 228 ADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAGAI 270
A +V G + V +T + KSR+VGDV+Y + GA+
Sbjct: 70 AHLVTNGTVVGPVNVTETLEMQSKSRIVGDVEYASIEMHQGAV 112
>UniRef50_Q18E84 Cluster: ATP-dependent DNA helicase; n=1;
Haloquadratum walsbyi DSM 16790|Rep: ATP-dependent DNA
helicase - Haloquadratum walsbyi (strain DSM 16790)
Length = 2216
Score = 34.3 bits (75), Expect = 3.9
Identities = 24/78 (30%), Positives = 44/78 (56%), Gaps = 4/78 (5%)
Query: 64 ALTINRDSDITEEQLLSEIQN-LNED-NSVDGILVQLPVPDTINERRVCDAIA-PEKDID 120
++TI R +++ Q ++ + LN D NSV+ ++ PV + + RVCDAI+ +DI
Sbjct: 713 SITILRTEIVSQYQNIAAAADALNIDVNSVEALITGQPVVSDVID-RVCDAISVSSEDIT 771
Query: 121 GFHIINIGRLCVDLPTIV 138
H+I ++LP ++
Sbjct: 772 IHHVIGPTGTAIELPEVL 789
>UniRef50_Q9TW65 Cluster: Dystrophin-1; n=4; root|Rep: Dystrophin-1 -
Caenorhabditis elegans
Length = 3674
Score = 34.3 bits (75), Expect = 3.9
Identities = 18/52 (34%), Positives = 27/52 (51%)
Query: 3 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKV 54
R LD +A +KEL ++ + VSL +RA I C + G P H +K+
Sbjct: 1734 RNLDDVDIAKSTRKELAERDSHIVSLTSRATAIHCALPGKGPQLHDVTLDKL 1785
>UniRef50_A7DV73 Cluster: Putative uncharacterized protein vep13;
n=1; Vibrio vulnificus|Rep: Putative uncharacterized
protein vep13 - Vibrio vulnificus
Length = 179
Score = 33.9 bits (74), Expect = 5.2
Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 9/95 (9%)
Query: 60 VGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDI 119
+G D + D T EQ LS +LNE N+ D L D+ R + +AIA + D
Sbjct: 29 LGYDVWGKDTDPQGTYEQFLS---SLNEPNNADFFLYDTQGADSAINRTLLEAIA-QADS 84
Query: 120 DGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNI 154
D I+ + DL AL+V +L +FN+
Sbjct: 85 DNLIIVPVQPTETDLD-----RALSVAHLLHQFNV 114
>UniRef50_A6VS59 Cluster: Short-chain dehydrogenase/reductase SDR;
n=33; Bacteria|Rep: Short-chain dehydrogenase/reductase
SDR - Marinomonas sp. MWYL1
Length = 260
Score = 33.5 bits (73), Expect = 6.8
Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 9/91 (9%)
Query: 152 FNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCR 211
F+++ GR A+V G +K +G + LH G V R PKD LE
Sbjct: 3 FDLELNGRIALVTGGTKGLGAAVVESLH---------GAGVHVIAVARSVPKDALEGISY 53
Query: 212 NADIIITATGLPKLIKADMVKPGATIIDVGI 242
++TA G L+ + K G I V +
Sbjct: 54 IEGDLLTAAGCSALVSTVLEKFGGVDIVVNV 84
>UniRef50_A5MC89 Cluster: Putative uncharacterized protein; n=1;
Streptococcus pneumoniae SP14-BS69|Rep: Putative
uncharacterized protein - Streptococcus pneumoniae
SP14-BS69
Length = 65
Score = 33.5 bits (73), Expect = 6.8
Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Query: 1 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVG-DDPASHTYVRNKVEAAKF 59
M +I+DGKALA +++ +L +K A+ P + I+VG PA T+ + + +
Sbjct: 1 MTQIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVGIIQPAKSTFATRRGQLLRL 60
Query: 60 VGI 62
V +
Sbjct: 61 VPV 63
>UniRef50_A3SDC1 Cluster: Ornithine cyclodeaminase; n=2;
Sulfitobacter|Rep: Ornithine cyclodeaminase -
Sulfitobacter sp. EE-36
Length = 315
Score = 33.5 bits (73), Expect = 6.8
Identities = 24/79 (30%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 204 DKLEAYCRNADIIITATGLPK-LIKADMVKPGATIIDVGI----TRITDENGKSRLVGDV 258
D LE CR AD+I T T + +I+ D +KPG+ + +G R +D+ + V
Sbjct: 183 DDLETACRAADVISTVTASTRPIIQGDWLKPGSHLDLIGAFKGDMRESDDQAIQQAEVFV 242
Query: 259 DYEEVSKIAGAIT-PVPGG 276
D + +AG ++ P+ G
Sbjct: 243 DLRAGASLAGDLSQPLEAG 261
>UniRef50_A3DEC5 Cluster: Putative stage IV sporulation YqfD; n=1;
Clostridium thermocellum ATCC 27405|Rep: Putative stage
IV sporulation YqfD - Clostridium thermocellum (strain
ATCC 27405 / DSM 1237)
Length = 398
Score = 33.5 bits (73), Expect = 6.8
Identities = 23/74 (31%), Positives = 35/74 (47%), Gaps = 2/74 (2%)
Query: 196 ICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLV 255
+ RY D +EA D A G+ A+ + GATI+D + I +ENG+ ++
Sbjct: 321 VIERYYENDLVEADISLEDAKENAAGIAYRKAAENIPEGATIVDKRVNFIENENGE--II 378
Query: 256 GDVDYEEVSKIAGA 269
DV E + I A
Sbjct: 379 ADVIIECLEDIGVA 392
>UniRef50_O74539 Cluster: Peroxide stress-activated histidine kinase
mak3; n=1; Schizosaccharomyces pombe|Rep: Peroxide
stress-activated histidine kinase mak3 -
Schizosaccharomyces pombe (Fission yeast)
Length = 2344
Score = 33.5 bits (73), Expect = 6.8
Identities = 14/47 (29%), Positives = 28/47 (59%)
Query: 75 EEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
EEQ+ ++ + +D+S++ +L+ L + D + R C IA E ++ G
Sbjct: 1438 EEQIDDDVSPVAQDSSLEELLISLDIIDLTSVMRSCQTIASEIELTG 1484
>UniRef50_Q7N1T7 Cluster: Similarities with the N-terminal region of
tail fiber protein; n=2; Photorhabdus luminescens subsp.
laumondii|Rep: Similarities with the N-terminal region
of tail fiber protein - Photorhabdus luminescens subsp.
laumondii
Length = 447
Score = 33.1 bits (72), Expect = 9.0
Identities = 20/54 (37%), Positives = 33/54 (61%), Gaps = 8/54 (14%)
Query: 221 GLPKLIKADMVKPGATIIDVGITRITDENGKS-------RLVGDVDYEEVSKIA 267
GL ++ D++ P AT+I+ GIT++TD+ G S +LV DV+ +K+A
Sbjct: 162 GLGEIATQDLI-PDATLIEKGITQLTDKTGNSNTLAATQKLVSDVNDNANNKLA 214
>UniRef50_Q62L13 Cluster: Hydrolase; n=16; Burkholderia|Rep:
Hydrolase - Burkholderia mallei (Pseudomonas mallei)
Length = 330
Score = 33.1 bits (72), Expect = 9.0
Identities = 24/71 (33%), Positives = 36/71 (50%), Gaps = 7/71 (9%)
Query: 95 LVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNI 154
LV LP+PD R A+ + G+H+ + R DLP I+P A+++ R +
Sbjct: 156 LVGLPIPDFTAPR--WRALLARANALGWHV-EVHRRAADLPAIIP----ALLDQSCRVVV 208
Query: 155 DTFGRNAVVIG 165
D FGR A +G
Sbjct: 209 DHFGRPAPHLG 219
>UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10 -
Vibrio marinus (Moritella marina)
Length = 2011
Score = 33.1 bits (72), Expect = 9.0
Identities = 21/82 (25%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 179 HSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATI- 237
H D LG++A + + Y K+ L N I T + + + +
Sbjct: 1909 HQDPVMPGSLGVEAIIELMQTYALKNDLGGKFANPRFIAPMTQVDWKYRGQITPLNKQMS 1968
Query: 238 IDVGITRITDENGKSRLVGDVD 259
+DV IT I ++ G+ R+VGD +
Sbjct: 1969 LDVHITEIVNDAGEVRIVGDAN 1990
>UniRef50_Q7CTP3 Cluster: AGR_L_1807p; n=4; Proteobacteria|Rep:
AGR_L_1807p - Agrobacterium tumefaciens (strain C58 /
ATCC 33970)
Length = 328
Score = 33.1 bits (72), Expect = 9.0
Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 5/46 (10%)
Query: 210 CRNADIIITAT-GLPKLIKADMVKPGATIIDVGITRITDENGKSRL 254
C ADII+TAT L +AD V+PG + +G +D GK L
Sbjct: 200 CAEADIIVTATSSRAPLFEADWVRPGTHVASMG----SDARGKQEL 241
>UniRef50_A5USY0 Cluster: Shikimate/quinate 5-dehydrogenase; n=5;
Chloroflexi (class)|Rep: Shikimate/quinate
5-dehydrogenase - Roseiflexus sp. RS-1
Length = 685
Score = 33.1 bits (72), Expect = 9.0
Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 2/44 (4%)
Query: 199 RYTPKDKLEAYCRNADIIITATGL--PKLIKADMVKPGATIIDV 240
R T +AY D+I+T T ++I D +KPGA + DV
Sbjct: 517 RVTATTSADAYLAECDLIVTTTSALSGRVINVDKLKPGAVVCDV 560
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.319 0.136 0.388
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 330,055,042
Number of Sequences: 1657284
Number of extensions: 13856289
Number of successful extensions: 34688
Number of sequences better than 10.0: 142
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 34241
Number of HSP's gapped (non-prelim): 162
length of query: 301
length of database: 575,637,011
effective HSP length: 100
effective length of query: 201
effective length of database: 409,908,611
effective search space: 82391630811
effective search space used: 82391630811
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 72 (33.1 bits)
- SilkBase 1999-2023 -