Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002355-TA|BGIBMGA002355-PA|IPR000672|Tetrahydrofolate
dehydrogenase/cyclohydrolase
(301 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for ... 354 2e-97
BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofola... 354 2e-97
BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofol... 354 2e-97
AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein. 354 2e-97
AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofol... 352 8e-97
AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofol... 352 8e-97
BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofola... 285 2e-76
AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15... 259 7e-69
J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein. 211 3e-54
BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofola... 211 3e-54
BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofola... 211 3e-54
BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein. 182 1e-45
BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein. 105 3e-22
BC065771-1|AAH65771.1| 70|Homo sapiens MTHFD2L protein protein. 89 2e-17
BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein. 73 2e-12
AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate syn... 73 2e-12
AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofola... 73 2e-12
AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein pr... 73 2e-12
AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofola... 73 2e-12
AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofola... 73 2e-12
AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial C1-tetrah... 73 2e-12
AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofola... 69 2e-11
AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofola... 69 2e-11
AY374131-1|AAQ82697.1| 275|Homo sapiens truncated C1-tetrahydro... 66 1e-10
AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofola... 56 2e-07
AL035086-5|CAI42792.1| 120|Homo sapiens methylenetetrahydrofola... 44 9e-04
AC097470-1|AAY40953.1| 43|Homo sapiens unknown protein. 43 0.001
AL035086-4|CAI42791.1| 120|Homo sapiens methylenetetrahydrofola... 40 0.011
Z99130-1|CAB16205.1| 803|Homo sapiens dJ83L6.1 (zinc finger pro... 31 3.7
L14788-1|AAC37522.1| 403|Homo sapiens DNA-binding protein protein. 31 3.7
L14787-1|AAC37521.1| 457|Homo sapiens DNA-binding protein protein. 31 3.7
BC059356-1|AAH59356.1| 799|Homo sapiens zinc finger, X-linked, ... 31 3.7
AL034396-1|CAB46717.1| 799|Homo sapiens zinc finger, X-linked, ... 31 3.7
AL031115-1|CAD92603.2| 803|Homo sapiens zinc finger, X-linked, ... 31 3.7
>X16396-1|CAA34431.1| 344|Homo sapiens protein ( Human mRNA for
NAD-dependent methylene tetrahydrofolate dehydrogenase
cyclohydrolase (EC 1.5.1.15). ).
Length = 344
Score = 354 bits (870), Expect = 2e-97
Identities = 166/294 (56%), Positives = 228/294 (77%), Gaps = 2/294 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 90
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG
Sbjct: 91 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 150
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+IN+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D
Sbjct: 151 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 210
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
HE G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVG
Sbjct: 211 GAHERP-GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 269
Query: 242 ITRITDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
I R+ D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+
Sbjct: 270 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 323
>BC017054-1|AAH17054.2| 350|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 350
Score = 354 bits (870), Expect = 2e-97
Identities = 166/294 (56%), Positives = 228/294 (77%), Gaps = 2/294 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG
Sbjct: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+IN+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D
Sbjct: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
HE G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVG
Sbjct: 217 GAHERP-GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 275
Query: 242 ITRITDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
I R+ D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+
Sbjct: 276 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 329
>BC001548-1|AAH01548.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2, precursor protein.
Length = 344
Score = 354 bits (870), Expect = 2e-97
Identities = 166/294 (56%), Positives = 228/294 (77%), Gaps = 2/294 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 90
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG
Sbjct: 91 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 150
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+IN+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D
Sbjct: 151 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 210
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
HE G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVG
Sbjct: 211 GAHERP-GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 269
Query: 242 ITRITDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
I R+ D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+
Sbjct: 270 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 323
>AC073263-5|AAX93061.1| 344|Homo sapiens unknown protein.
Length = 344
Score = 354 bits (870), Expect = 2e-97
Identities = 166/294 (56%), Positives = 228/294 (77%), Gaps = 2/294 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 90
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG
Sbjct: 91 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 150
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+IN+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D
Sbjct: 151 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 210
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
HE G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVG
Sbjct: 211 GAHERP-GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 269
Query: 242 ITRITDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
I R+ D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+
Sbjct: 270 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 323
>AK223041-1|BAD96761.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 352 bits (866), Expect = 8e-97
Identities = 165/294 (56%), Positives = 227/294 (77%), Gaps = 2/294 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA G
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVAG 90
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG
Sbjct: 91 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 150
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+IN+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D
Sbjct: 151 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 210
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
HE G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVG
Sbjct: 211 GAHERP-GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 269
Query: 242 ITRITDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
I R+ D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+
Sbjct: 270 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 323
>AK222826-1|BAD96546.1| 344|Homo sapiens methylene tetrahydrofolate
dehydrogenase 2 precursor variant protein.
Length = 344
Score = 352 bits (866), Expect = 8e-97
Identities = 165/294 (56%), Positives = 227/294 (77%), Gaps = 2/294 (0%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61
A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+ G++PASH+YV NK AA VG
Sbjct: 31 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILAGENPASHSYVLNKTRAAAVVG 90
Query: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121
I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG
Sbjct: 91 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 150
Query: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181
FH+IN+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D
Sbjct: 151 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 210
Query: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241
HE G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVG
Sbjct: 211 GAHERP-GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 269
Query: 242 ITRITDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
I R+ D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+
Sbjct: 270 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 323
>BC015062-1|AAH15062.1| 248|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2, methenyltetrahydro
protein.
Length = 248
Score = 285 bits (698), Expect = 2e-76
Identities = 135/227 (59%), Positives = 178/227 (78%), Gaps = 2/227 (0%)
Query: 69 RDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIG 128
+ + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DGFH+IN+G
Sbjct: 2 KPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVG 61
Query: 129 RLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGL 188
R+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D HE
Sbjct: 62 RMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERP- 120
Query: 189 GMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVGITRITDE 248
G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVGI R+ D
Sbjct: 121 GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDP 180
Query: 249 -NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294
K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+
Sbjct: 181 VTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 227
>AK023167-1|BAB14441.1| 236|Homo sapiens ohydrolase (EC 1.5.1.15).
protein.
Length = 236
Score = 259 bits (635), Expect = 7e-69
Identities = 125/192 (65%), Positives = 153/192 (79%), Gaps = 2/192 (1%)
Query: 104 INERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVV 163
++ER +C+ IAPEKD+DGFHIINIGRLC+D +++PATA AV E++KR I TFG+N VV
Sbjct: 42 VDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVV 101
Query: 164 IGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLP 223
GRSKNVGMPIAM+LH+D HE G DATVTI HRYTPK++L+ + + ADIII A G+P
Sbjct: 102 AGRSKNVGMPIAMLLHTDGEHERP-GGDATVTIAHRYTPKEQLKIHTQLADIIIVAAGIP 160
Query: 224 KLIKADMVKPGATIIDVGITRITDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTV 282
KLI +DMVK GA +IDVGI + D GK++LVGDVD+E V K AG ITPVPGGVGPMTV
Sbjct: 161 KLITSDMVKEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTV 220
Query: 283 AMLMHNTFQAAQ 294
AML+ NT AA+
Sbjct: 221 AMLLKNTLLAAK 232
>J04031-1|AAA59574.1| 935|Homo sapiens MTHFD protein.
Length = 935
Score = 211 bits (515), Expect = 3e-54
Identities = 124/301 (41%), Positives = 182/301 (60%), Gaps = 20/301 (6%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVS-LGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
A IL+GK ++ +I+ LK ++ Q + P + + VG+ S+ Y+ K++AA+ +
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVP--DTINERRVCDAIAPEKD 118
GI A I TE +++ I +LNED++V G LVQLP+ ++IN V +AIAPEKD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 119 IDGFHIINIGRLCV-DL-PTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAM 176
+DG IN GRL DL +P T +E++K + GR+AVV+GRSK VG P+
Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPM-- 181
Query: 177 MLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGAT 236
H+ L +ATVT CH T L+ DI++ ATG P+++K + +KPGA
Sbjct: 182 -------HDLLLWNNATVTTCHSKTAH--LDEEVNKGDILVVATGQPEMVKGEWIKPGAI 232
Query: 237 IIDVGITRITDE---NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAA 293
+ID GI + D+ NG+ ++VGDV Y+E + A ITPVPGGVGPMTVAMLM +T ++A
Sbjct: 233 VIDCGINYVPDDKKPNGR-KVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESA 291
Query: 294 Q 294
+
Sbjct: 292 K 292
>BC050420-1|AAH50420.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 211 bits (515), Expect = 3e-54
Identities = 124/301 (41%), Positives = 182/301 (60%), Gaps = 20/301 (6%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVS-LGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
A IL+GK ++ +I+ LK ++ Q + P + + VG+ S+ Y+ K++AA+ +
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVP--DTINERRVCDAIAPEKD 118
GI A I TE +++ I +LNED++V G LVQLP+ ++IN V +AIAPEKD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 119 IDGFHIINIGRLCV-DL-PTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAM 176
+DG IN GRL DL +P T +E++K + GR+AVV+GRSK VG P+
Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPM-- 181
Query: 177 MLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGAT 236
H+ L +ATVT CH T L+ DI++ ATG P+++K + +KPGA
Sbjct: 182 -------HDLLLWNNATVTTCHSKTAH--LDEEVNKGDILVVATGQPEMVKGEWIKPGAI 232
Query: 237 IIDVGITRITDE---NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAA 293
+ID GI + D+ NG+ ++VGDV Y+E + A ITPVPGGVGPMTVAMLM +T ++A
Sbjct: 233 VIDCGINYVPDDKKPNGR-KVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESA 291
Query: 294 Q 294
+
Sbjct: 292 K 292
>BC009806-1|AAH09806.1| 935|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1, methenyltetrahydro
protein.
Length = 935
Score = 211 bits (515), Expect = 3e-54
Identities = 124/301 (41%), Positives = 182/301 (60%), Gaps = 20/301 (6%)
Query: 2 ARILDGKALAMEIKKELKQKIAQWVS-LGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 60
A IL+GK ++ +I+ LK ++ Q + P + + VG+ S+ Y+ K++AA+ +
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 61 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVP--DTINERRVCDAIAPEKD 118
GI A I TE +++ I +LNED++V G LVQLP+ ++IN V +AIAPEKD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 119 IDGFHIINIGRLCV-DL-PTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAM 176
+DG IN GRL DL +P T +E++K + GR+AVV+GRSK VG P+
Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPM-- 181
Query: 177 MLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGAT 236
H+ L +ATVT CH T L+ DI++ ATG P+++K + +KPGA
Sbjct: 182 -------HDLLLWNNATVTTCHSKTAH--LDEEVNKGDILVVATGQPEMVKGEWIKPGAI 232
Query: 237 IIDVGITRITDE---NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAA 293
+ID GI + D+ NG+ ++VGDV Y+E + A ITPVPGGVGPMTVAMLM +T ++A
Sbjct: 233 VIDCGINYVPDDKKPNGR-KVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESA 291
Query: 294 Q 294
+
Sbjct: 292 K 292
>BC032771-1|AAH32771.1| 146|Homo sapiens MTHFD2L protein protein.
Length = 146
Score = 182 bits (444), Expect = 1e-45
Identities = 86/132 (65%), Positives = 106/132 (80%), Gaps = 1/132 (0%)
Query: 88 DNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVE 147
D V GILVQLP+PD ++ER +C+ IAPEKD+DGFHIINIGRLC+D +++PATA AV E
Sbjct: 2 DPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWE 61
Query: 148 MLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLE 207
++KR I TFG+N VV GRSKNVGMPIAM+LH+D HE G DATVTI HRYTPK++L+
Sbjct: 62 IIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERP-GGDATVTIAHRYTPKEQLK 120
Query: 208 AYCRNADIIITA 219
+ + ADIII A
Sbjct: 121 IHTQLADIIIVA 132
>BC037529-1|AAH37529.2| 106|Homo sapiens MTHFD2L protein protein.
Length = 106
Score = 105 bits (251), Expect = 3e-22
Identities = 48/95 (50%), Positives = 67/95 (70%)
Query: 10 LAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 69
+A I+KE+++ + WVSLGNR P + I+VGD+PASHTYVRNK+ AA VGI + I +
Sbjct: 1 MAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILK 60
Query: 70 DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI 104
D+++E+LL LN D V GILVQLP+P+ +
Sbjct: 61 PKDVSQEELLDVTDQLNMDPRVSGILVQLPLPEAV 95
>BC065771-1|AAH65771.1| 70|Homo sapiens MTHFD2L protein protein.
Length = 70
Score = 88.6 bits (210), Expect = 2e-17
Identities = 44/66 (66%), Positives = 51/66 (77%), Gaps = 1/66 (1%)
Query: 230 MVKPGATIIDVGITRITDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHN 288
MVK GA +IDVGI + D GK++LVGDVD+E V K AG ITPVPGGVGPMTVAML+ N
Sbjct: 1 MVKEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKN 60
Query: 289 TFQAAQ 294
T AA+
Sbjct: 61 TLLAAK 66
>BC110319-1|AAI10320.1| 900|Homo sapiens MTHFD1L protein protein.
Length = 900
Score = 72.5 bits (170), Expect = 2e-12
Identities = 51/209 (24%), Positives = 102/209 (48%), Gaps = 18/209 (8%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 20 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 76
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLK 150
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L+
Sbjct: 77 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 134
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
+ ++ G+ +V+G ++ + + ++T+ ++ + +L++
Sbjct: 135 KSGVNLDGKKILVVGAHGSLEAALQCLFQ----------RKGSMTMSIQWKTR-QLQSKL 183
Query: 211 RNADIIITATGLPKLIKADMVKPGATIID 239
ADI++ + P+ I ++PG T+++
Sbjct: 184 HEADIVVLGSPKPEEIPLTWIQPGTTVLN 212
>AY374130-1|AAQ82696.1| 978|Homo sapiens C1-tetrahydrofolate
synthase protein.
Length = 978
Score = 72.5 bits (170), Expect = 2e-12
Identities = 51/209 (24%), Positives = 102/209 (48%), Gaps = 18/209 (8%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 98 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 154
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLK 150
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L+
Sbjct: 155 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 212
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
+ ++ G+ +V+G ++ + + ++T+ ++ + +L++
Sbjct: 213 KSGVNLDGKKILVVGAHGSLEAALQCLFQ----------RKGSMTMSIQWKTR-QLQSKL 261
Query: 211 RNADIIITATGLPKLIKADMVKPGATIID 239
ADI++ + P+ I ++PG T+++
Sbjct: 262 HEADIVVLGSPKPEEIPLTWIQPGTTVLN 290
>AL133260-2|CAI95678.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 72.5 bits (170), Expect = 2e-12
Identities = 51/209 (24%), Positives = 102/209 (48%), Gaps = 18/209 (8%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 98 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 154
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLK 150
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L+
Sbjct: 155 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 212
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
+ ++ G+ +V+G ++ + + ++T+ ++ + +L++
Sbjct: 213 KSGVNLDGKKILVVGAHGSLEAALQCLFQ----------RKGSMTMSIQWKTR-QLQSKL 261
Query: 211 RNADIIITATGLPKLIKADMVKPGATIID 239
ADI++ + P+ I ++PG T+++
Sbjct: 262 HEADIVVLGSPKPEEIPLTWIQPGTTVLN 290
>AL117452-1|CAB55934.1| 917|Homo sapiens hypothetical protein
protein.
Length = 917
Score = 72.5 bits (170), Expect = 2e-12
Identities = 51/209 (24%), Positives = 102/209 (48%), Gaps = 18/209 (8%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 37 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 93
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLK 150
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L+
Sbjct: 94 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 151
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
+ ++ G+ +V+G ++ + + ++T+ ++ + +L++
Sbjct: 152 KSGVNLDGKKILVVGAHGSLEAALQCLFQ----------RKGSMTMSIQWKTR-QLQSKL 200
Query: 211 RNADIIITATGLPKLIKADMVKPGATIID 239
ADI++ + P+ I ++PG T+++
Sbjct: 201 HEADIVVLGSPKPEEIPLTWIQPGTTVLN 229
>AL049694-3|CAI95774.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 72.5 bits (170), Expect = 2e-12
Identities = 51/209 (24%), Positives = 102/209 (48%), Gaps = 18/209 (8%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 98 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 154
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLK 150
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L+
Sbjct: 155 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 212
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
+ ++ G+ +V+G ++ + + ++T+ ++ + +L++
Sbjct: 213 KSGVNLDGKKILVVGAHGSLEAALQCLFQ----------RKGSMTMSIQWKTR-QLQSKL 261
Query: 211 RNADIIITATGLPKLIKADMVKPGATIID 239
ADI++ + P+ I ++PG T+++
Sbjct: 262 HEADIVVLGSPKPEEIPLTWIQPGTTVLN 290
>AL035086-7|CAI42794.1| 978|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 978
Score = 72.5 bits (170), Expect = 2e-12
Identities = 51/209 (24%), Positives = 102/209 (48%), Gaps = 18/209 (8%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 98 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 154
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLK 150
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L+
Sbjct: 155 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 212
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
+ ++ G+ +V+G ++ + + ++T+ ++ + +L++
Sbjct: 213 KSGVNLDGKKILVVGAHGSLEAALQCLFQ----------RKGSMTMSIQWKTR-QLQSKL 261
Query: 211 RNADIIITATGLPKLIKADMVKPGATIID 239
ADI++ + P+ I ++PG T+++
Sbjct: 262 HEADIVVLGSPKPEEIPLTWIQPGTTVLN 290
>AB127387-1|BAD93193.1| 978|Homo sapiens mitochondrial
C1-tetrahydrofolate synthetase protein.
Length = 978
Score = 72.5 bits (170), Expect = 2e-12
Identities = 51/209 (24%), Positives = 102/209 (48%), Gaps = 18/209 (8%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 98 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 154
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLK 150
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L+
Sbjct: 155 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 212
Query: 151 RFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYC 210
+ ++ G+ +V+G ++ + + ++T+ ++ + +L++
Sbjct: 213 KSGVNLDGKKILVVGAHGSLEAALQCLFQ----------RKGSMTMSIQWKTR-QLQSKL 261
Query: 211 RNADIIITATGLPKLIKADMVKPGATIID 239
ADI++ + P+ I ++PG T+++
Sbjct: 262 HEADIVVLGSPKPEEIPLTWIQPGTTVLN 290
>AL049694-4|CAI95775.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 68.9 bits (161), Expect = 2e-11
Identities = 52/210 (24%), Positives = 101/210 (48%), Gaps = 19/210 (9%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 57 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 113
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEML- 149
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L
Sbjct: 114 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 171
Query: 150 KRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAY 209
K ++ G+ +V+G ++ + + ++T+ ++ + +L++
Sbjct: 172 KSVGVNLDGKKILVVGAHGSLEAALQCLFQ----------RKGSMTMSIQWKTR-QLQSK 220
Query: 210 CRNADIIITATGLPKLIKADMVKPGATIID 239
ADI++ + P+ I ++PG T+++
Sbjct: 221 LHEADIVVLGSPKPEEIPLTWIQPGTTVLN 250
>AL035086-8|CAI42795.1| 331|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 331
Score = 68.9 bits (161), Expect = 2e-11
Identities = 52/210 (24%), Positives = 101/210 (48%), Gaps = 19/210 (9%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 57 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 113
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEML- 149
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L
Sbjct: 114 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 171
Query: 150 KRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAY 209
K ++ G+ +V+G ++ + + ++T+ ++ + +L++
Sbjct: 172 KSVGVNLDGKKILVVGAHGSLEAALQCLFQ----------RKGSMTMSIQWKTR-QLQSK 220
Query: 210 CRNADIIITATGLPKLIKADMVKPGATIID 239
ADI++ + P+ I ++PG T+++
Sbjct: 221 LHEADIVVLGSPKPEEIPLTWIQPGTTVLN 250
>AY374131-1|AAQ82697.1| 275|Homo sapiens truncated
C1-tetrahydrofolate synthase protein.
Length = 275
Score = 66.5 bits (155), Expect = 1e-10
Identities = 41/135 (30%), Positives = 70/135 (51%), Gaps = 7/135 (5%)
Query: 33 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 92
P + I GDD +N E A G++ I D +E +++ EI +NED V
Sbjct: 98 PVLAIIQAGDDNLMQEINQNLAEEA---GLNITHICLPPDSSEAEIIDEILKINEDTRVH 154
Query: 93 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLK 150
G+ +Q + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L+
Sbjct: 155 GLALQ--ISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLE 212
Query: 151 RFNIDTFGRNAVVIG 165
+ ++ G+ +V+G
Sbjct: 213 KSGVNLDGKKILVVG 227
>AL035086-6|CAI42793.1| 114|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 114
Score = 56.0 bits (129), Expect = 2e-07
Identities = 32/105 (30%), Positives = 58/105 (55%), Gaps = 4/105 (3%)
Query: 57 AKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPE 116
A+ G++ I D +E +++ EI +NED V G+ +Q + + + +V +A+ PE
Sbjct: 9 AEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQ--ISENLFSNKVLNALKPE 66
Query: 117 KDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKRFNIDTFGR 159
KD+DG IN+G+L V A AV+E+L++ ++ G+
Sbjct: 67 KDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGK 111
>AL035086-5|CAI42792.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 43.6 bits (98), Expect = 9e-04
Identities = 22/70 (31%), Positives = 40/70 (57%), Gaps = 2/70 (2%)
Query: 98 LPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKRFNID 155
L + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L++ ++
Sbjct: 3 LQISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVN 62
Query: 156 TFGRNAVVIG 165
G+ +V+G
Sbjct: 63 LDGKKILVVG 72
>AC097470-1|AAY40953.1| 43|Homo sapiens unknown protein.
Length = 43
Score = 43.2 bits (97), Expect = 0.001
Identities = 19/29 (65%), Positives = 24/29 (82%)
Query: 191 DATVTICHRYTPKDKLEAYCRNADIIITA 219
DATVTI HRYTPK++L+ + + ADIII A
Sbjct: 1 DATVTIAHRYTPKEQLKIHTQLADIIIVA 29
>AL035086-4|CAI42791.1| 120|Homo sapiens methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 1-like protein.
Length = 120
Score = 39.9 bits (89), Expect = 0.011
Identities = 23/71 (32%), Positives = 39/71 (54%), Gaps = 3/71 (4%)
Query: 98 LPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEML-KRFNI 154
L + + + +V +A+ PEKD+DG IN+G+L V A AV+E+L K +
Sbjct: 2 LQISENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSVGV 61
Query: 155 DTFGRNAVVIG 165
+ G+ +V+G
Sbjct: 62 NLDGKKILVVG 72
>Z99130-1|CAB16205.1| 803|Homo sapiens dJ83L6.1 (zinc finger
protein ZXDA (ZFPA)) protein.
Length = 803
Score = 31.5 bits (68), Expect = 3.7
Identities = 26/124 (20%), Positives = 53/124 (42%), Gaps = 6/124 (4%)
Query: 153 NIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRN 212
++DT+ + +K +M H KRH+ G + A + + TP +L + +N
Sbjct: 541 DVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQN 600
Query: 213 ----ADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAG 268
A+I+ + +P A ++ +++ GI I + S L G + + +
Sbjct: 601 DLSDAEIVSLFSDVPDSTSAALL--DTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQ 658
Query: 269 AITP 272
A+ P
Sbjct: 659 AVDP 662
>L14788-1|AAC37522.1| 403|Homo sapiens DNA-binding protein protein.
Length = 403
Score = 31.5 bits (68), Expect = 3.7
Identities = 26/124 (20%), Positives = 53/124 (42%), Gaps = 6/124 (4%)
Query: 153 NIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRN 212
++DT+ + +K +M H KRH+ G + A + + TP +L + +N
Sbjct: 235 DVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQN 294
Query: 213 ----ADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAG 268
A+I+ + +P A ++ +++ GI I + S L G + + +
Sbjct: 295 DLSDAEIVSLFSDVPDSTSAALL--DTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQ 352
Query: 269 AITP 272
A+ P
Sbjct: 353 AVDP 356
>L14787-1|AAC37521.1| 457|Homo sapiens DNA-binding protein protein.
Length = 457
Score = 31.5 bits (68), Expect = 3.7
Identities = 26/124 (20%), Positives = 53/124 (42%), Gaps = 6/124 (4%)
Query: 153 NIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRN 212
++DT+ + +K +M H KRH+ G + A + + TP +L + +N
Sbjct: 235 DVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQN 294
Query: 213 ----ADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAG 268
A+I+ + +P A ++ +++ GI I + S L G + + +
Sbjct: 295 DLSDAEIVSLFSDVPDSTSAALL--DTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQ 352
Query: 269 AITP 272
A+ P
Sbjct: 353 AVDP 356
>BC059356-1|AAH59356.1| 799|Homo sapiens zinc finger, X-linked,
duplicated A protein.
Length = 799
Score = 31.5 bits (68), Expect = 3.7
Identities = 26/124 (20%), Positives = 53/124 (42%), Gaps = 6/124 (4%)
Query: 153 NIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRN 212
++DT+ + +K +M H KRH+ G + A + + TP +L + +N
Sbjct: 537 DVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQN 596
Query: 213 ----ADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAG 268
A+I+ + +P A ++ +++ GI I + S L G + + +
Sbjct: 597 DLSDAEIVSLFSDVPDSTSAALL--DTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQ 654
Query: 269 AITP 272
A+ P
Sbjct: 655 AVDP 658
>AL034396-1|CAB46717.1| 799|Homo sapiens zinc finger, X-linked,
duplicated A protein.
Length = 799
Score = 31.5 bits (68), Expect = 3.7
Identities = 26/124 (20%), Positives = 53/124 (42%), Gaps = 6/124 (4%)
Query: 153 NIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRN 212
++DT+ + +K +M H KRH+ G + A + + TP +L + +N
Sbjct: 537 DVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQN 596
Query: 213 ----ADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAG 268
A+I+ + +P A ++ +++ GI I + S L G + + +
Sbjct: 597 DLSDAEIVSLFSDVPDSTSAALL--DTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQ 654
Query: 269 AITP 272
A+ P
Sbjct: 655 AVDP 658
>AL031115-1|CAD92603.2| 803|Homo sapiens zinc finger, X-linked,
duplicated B protein.
Length = 803
Score = 31.5 bits (68), Expect = 3.7
Identities = 26/124 (20%), Positives = 53/124 (42%), Gaps = 6/124 (4%)
Query: 153 NIDTFGRNAVVIGRSKNVGMPIAMMLHSDKRHESGLGMDATVTICHRYTPKDKLEAYCRN 212
++DT+ + +K +M H KRH+ G + A + + TP +L + +N
Sbjct: 541 DVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQN 600
Query: 213 ----ADIIITATGLPKLIKADMVKPGATIIDVGITRITDENGKSRLVGDVDYEEVSKIAG 268
A+I+ + +P A ++ +++ GI I + S L G + + +
Sbjct: 601 DLSDAEIVSLFSDVPDSTSAALL--DTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQ 658
Query: 269 AITP 272
A+ P
Sbjct: 659 AVDP 662
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.136 0.388
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 41,551,732
Number of Sequences: 224733
Number of extensions: 1678629
Number of successful extensions: 3015
Number of sequences better than 10.0: 34
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2936
Number of HSP's gapped (non-prelim): 43
length of query: 301
length of database: 73,234,838
effective HSP length: 90
effective length of query: 211
effective length of database: 53,008,868
effective search space: 11184871148
effective search space used: 11184871148
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 65 (30.3 bits)
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