Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002346-TA|BGIBMGA002346-PA|IPR006140|D-isomer specific
2-hydroxyacid dehydrogenase, NAD-binding, IPR006139|D-isomer specific
2-hydroxyacid dehydrogenase, catalytic region
(487 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q5BU19 Cluster: Ribeye a protein; n=4; Clupeocephala|Re... 536 e-151
UniRef50_P56545 Cluster: C-terminal-binding protein 2; n=98; Coe... 535 e-150
UniRef50_Q4S2R7 Cluster: Chromosome 17 SCAF14760, whole genome s... 411 e-113
UniRef50_Q20595 Cluster: Putative uncharacterized protein; n=3; ... 370 e-101
UniRef50_Q13ZE9 Cluster: Putative dehydrogenase, D-3-phosphoglyc... 179 1e-43
UniRef50_Q8TYK0 Cluster: Predicted dehydrogenase related to phos... 177 4e-43
UniRef50_Q58424 Cluster: D-3-phosphoglycerate dehydrogenase; n=7... 175 3e-42
UniRef50_A3S1P6 Cluster: Dehydrogenase; n=1; Prochlorococcus mar... 172 2e-41
UniRef50_A6FZB7 Cluster: Putative dehydrogenase; n=1; Plesiocyst... 169 2e-40
UniRef50_A4EQ78 Cluster: Dehydrogenase; n=1; Roseobacter sp. SK2... 165 2e-39
UniRef50_A2U4T1 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 160 7e-38
UniRef50_A7HM61 Cluster: Glyoxylate reductase; n=1; Fervidobacte... 159 1e-37
UniRef50_Q8EMM3 Cluster: Dehydrogenase; n=2; cellular organisms|... 157 5e-37
UniRef50_Q67TJ9 Cluster: Phosphoglycerate dehydrogenase; n=1; Sy... 155 2e-36
UniRef50_Q89EL0 Cluster: Blr7063 protein; n=1; Bradyrhizobium ja... 155 3e-36
UniRef50_A6UQN3 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 154 4e-36
UniRef50_Q7UQL2 Cluster: Phosphoglycerate dehydrogenase; n=2; Pl... 153 8e-36
UniRef50_Q9WYG2 Cluster: Phosphoglycerate dehydrogenase, putativ... 153 1e-35
UniRef50_Q483F8 Cluster: Putative glyoxylate reductase; n=1; Col... 152 2e-35
UniRef50_Q1CG62 Cluster: D-isomer specific 2-hydroxyacid dehydro... 151 3e-35
UniRef50_Q8R716 Cluster: Phosphoglycerate dehydrogenase and rela... 151 5e-35
UniRef50_O67741 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 150 7e-35
UniRef50_O66939 Cluster: D-lactate dehydrogenase; n=1; Aquifex a... 149 2e-34
UniRef50_Q1PZY1 Cluster: Similar to D-3-phosphoglycerate dehydro... 149 2e-34
UniRef50_A6W4F1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 148 3e-34
UniRef50_Q81T55 Cluster: D-isomer specific 2-hydroxyacid dehydro... 147 5e-34
UniRef50_A6C853 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 147 7e-34
UniRef50_A5MYX9 Cluster: Putative uncharacterized protein; n=1; ... 147 7e-34
UniRef50_Q8EN61 Cluster: Phosphoglycerate dehydrogenase; n=2; Ba... 146 9e-34
UniRef50_A1SPF8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 146 9e-34
UniRef50_Q82U25 Cluster: D-isomer specific 2-hydroxyacid dehydro... 146 1e-33
UniRef50_A6CKS4 Cluster: Putative uncharacterized protein; n=1; ... 146 2e-33
UniRef50_A1HMI9 Cluster: Phosphoglycerate dehydrogenase; n=1; Th... 146 2e-33
UniRef50_Q9X1C1 Cluster: D-3-phosphoglycerate dehydrogenase; n=3... 145 2e-33
UniRef50_Q5KYJ7 Cluster: Dehydrogenase; n=3; Firmicutes|Rep: Deh... 145 2e-33
UniRef50_P73990 Cluster: D-isomer specific 2-hydroxyacid dehydro... 145 2e-33
UniRef50_A7CYD6 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 145 2e-33
UniRef50_Q18XF4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 145 3e-33
UniRef50_A7HDB1 Cluster: D-3-phosphoglycerate dehydrogenase; n=5... 144 3e-33
UniRef50_Q8YEC6 Cluster: Gluconate 2-dehydrogenase; n=72; Alphap... 144 5e-33
UniRef50_A0ZEB8 Cluster: Predicted dehydrogenase; n=6; Cyanobact... 144 5e-33
UniRef50_A5URV2 Cluster: D-isomer specific 2-hydroxyacid dehydro... 144 6e-33
UniRef50_Q5V1E2 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 144 6e-33
UniRef50_Q8EMJ8 Cluster: Hypothetical conserved protein; n=1; Oc... 143 8e-33
UniRef50_Q0EUV6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 143 1e-32
UniRef50_Q1AXS3 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 142 1e-32
UniRef50_Q9KP72 Cluster: 2-hydroxyacid dehydrogenase family prot... 142 2e-32
UniRef50_A5UQ03 Cluster: D-3-phosphoglycerate dehydrogenase; n=5... 142 2e-32
UniRef50_A1G3C5 Cluster: D-isomer specific 2-hydroxyacid dehydro... 142 2e-32
UniRef50_A6CXX0 Cluster: Dehydrogenase; n=1; Vibrio shilonii AK1... 141 3e-32
UniRef50_A1RDF9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 141 3e-32
UniRef50_Q6A5K9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 141 4e-32
UniRef50_Q2AHU0 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 141 4e-32
UniRef50_A1AQ02 Cluster: D-isomer specific 2-hydroxyacid dehydro... 141 4e-32
UniRef50_Q5FKH9 Cluster: Glyoxylate reductase; n=1; Lactobacillu... 140 6e-32
UniRef50_Q1GAM7 Cluster: D-isomer specific 2-hydroxyacid dehydro... 140 6e-32
UniRef50_UPI00015BAF48 Cluster: D-isomer specific 2-hydroxyacid ... 140 8e-32
UniRef50_O29445 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 140 8e-32
UniRef50_Q897N8 Cluster: D-3-phosphoglycerate dehydrogenase; n=4... 140 1e-31
UniRef50_Q0ETU3 Cluster: D-isomer specific 2-hydroxyacid dehydro... 140 1e-31
UniRef50_Q1IVI0 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 139 1e-31
UniRef50_Q11JH0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 139 1e-31
UniRef50_A4A9T4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 139 1e-31
UniRef50_Q6F7L0 Cluster: Glycerate dehydrogenase; n=3; Gammaprot... 139 2e-31
UniRef50_Q7MT26 Cluster: D-isomer specific 2-hydroxyacid dehydro... 138 2e-31
UniRef50_O24922 Cluster: Phosphoglycerate dehydrogenase; n=4; He... 138 2e-31
UniRef50_A3H6F3 Cluster: D-isomer specific 2-hydroxyacid dehydro... 138 2e-31
UniRef50_O33116 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 138 2e-31
UniRef50_Q2S4U0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 138 3e-31
UniRef50_P35136 Cluster: D-3-phosphoglycerate dehydrogenase; n=8... 138 3e-31
UniRef50_Q6W1I8 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 138 4e-31
UniRef50_A1SM51 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 138 4e-31
UniRef50_A4YFM2 Cluster: D-isomer specific 2-hydroxyacid dehydro... 138 4e-31
UniRef50_A3EWA5 Cluster: Phosphoglycerate dehydrogenase; n=2; Ba... 137 5e-31
UniRef50_Q8YIU3 Cluster: D-3-PHOSPHOGLYCERATE DEHYDROGENASE; n=7... 136 1e-30
UniRef50_Q5WLJ2 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 136 1e-30
UniRef50_A6C2G1 Cluster: Phosphoglycerate dehydrogenase; n=1; Pl... 136 1e-30
UniRef50_Q9UYH9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 136 1e-30
UniRef50_Q0W4A2 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 136 1e-30
UniRef50_O58320 Cluster: Glyoxylate reductase; n=16; cellular or... 136 1e-30
UniRef50_A6GGA6 Cluster: Probable 2-hydroxyacid dehydrogenase; n... 136 2e-30
UniRef50_A6C9V4 Cluster: Phosphoglycerate dehydrogenase; n=1; Pl... 136 2e-30
UniRef50_Q120S8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 135 2e-30
UniRef50_A0LMX1 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 135 2e-30
UniRef50_A3ZW64 Cluster: Phosphoglycerate dehydrogenase, putativ... 135 3e-30
UniRef50_A1ZGW5 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 135 3e-30
UniRef50_A1W9A3 Cluster: D-isomer specific 2-hydroxyacid dehydro... 135 3e-30
UniRef50_Q46VE6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 134 4e-30
UniRef50_O14465 Cluster: D-mandelate dehydrogenase; n=1; Rhodoto... 134 4e-30
UniRef50_UPI00015B605A Cluster: PREDICTED: similar to GA19489-PA... 134 5e-30
UniRef50_Q6MN05 Cluster: Phosphoglycerate dehydrogenase; n=1; Bd... 134 5e-30
UniRef50_A4FIF2 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 134 5e-30
UniRef50_P44501 Cluster: 2-hydroxyacid dehydrogenase homolog; n=... 134 5e-30
UniRef50_Q3KBX8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 134 7e-30
UniRef50_A1W7V5 Cluster: D-isomer specific 2-hydroxyacid dehydro... 134 7e-30
UniRef50_A1DFM4 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 134 7e-30
UniRef50_Q8PW48 Cluster: D-3-phosphoglycerate dehydrogenase; n=4... 134 7e-30
UniRef50_Q3AQU0 Cluster: D-3-phosphoglycerate dehydrogenase; n=5... 133 1e-29
UniRef50_A3ZMM2 Cluster: Dehydrogenase; n=1; Blastopirellula mar... 133 1e-29
UniRef50_A0QQ27 Cluster: Glyoxylate reductase; n=4; Mycobacteriu... 133 1e-29
UniRef50_UPI00015BD3AA Cluster: UPI00015BD3AA related cluster; n... 132 2e-29
UniRef50_P52643 Cluster: D-lactate dehydrogenase; n=118; cellula... 132 2e-29
UniRef50_UPI000023EBBC Cluster: hypothetical protein FG00146.1; ... 132 3e-29
UniRef50_Q3ZX05 Cluster: D-3-phosphoglycerate dehydrogenase; n=3... 132 3e-29
UniRef50_A4MA79 Cluster: D-isomer specific 2-hydroxyacid dehydro... 132 3e-29
UniRef50_Q97F10 Cluster: Possible phosphoglycerate dehydrogenase... 131 3e-29
UniRef50_Q74CK1 Cluster: Glycerate dehydrogenase; n=12; Bacteria... 131 3e-29
UniRef50_Q72KT6 Cluster: Glycerate dehydrogenase/glyoxylate redu... 131 3e-29
UniRef50_Q87JV4 Cluster: D-lactate dehydrogenase; n=6; Vibrio|Re... 131 5e-29
UniRef50_A6CRV0 Cluster: 2-hydroxyacid dehydrogenase; n=15; Baci... 131 5e-29
UniRef50_A0Y9Y1 Cluster: Glyoxylate reductase; n=2; unclassified... 131 5e-29
UniRef50_P73821 Cluster: D-3-phosphoglycerate dehydrogenase; n=3... 131 5e-29
UniRef50_Q4L766 Cluster: D-3-phosphoglycerate dehydrogenase; n=3... 130 8e-29
UniRef50_Q9K1Q1 Cluster: Glycerate dehydrogenase; n=6; cellular ... 130 1e-28
UniRef50_A0UAW1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 130 1e-28
UniRef50_Q5KFZ5 Cluster: Phosphoglycerate dehydrogenase, putativ... 130 1e-28
UniRef50_Q0FX01 Cluster: D-isomer specific 2-hydroxyacid dehydro... 129 1e-28
UniRef50_A0V9Y4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 129 2e-28
UniRef50_Q9K7P7 Cluster: Glycerate dehydrogenase; n=8; Bacillace... 128 2e-28
UniRef50_Q7WNI7 Cluster: Putative dehydrogenase; n=1; Bordetella... 128 2e-28
UniRef50_A6ULR7 Cluster: D-isomer specific 2-hydroxyacid dehydro... 128 2e-28
UniRef50_A0L0H4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 128 2e-28
UniRef50_A2R1X3 Cluster: Remark: D(--)-Mandelate dehydrogenase; ... 128 2e-28
UniRef50_Q7W397 Cluster: Putative 2-hydroxyacid dehydrogenase; n... 128 3e-28
UniRef50_A7HBU0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 128 3e-28
UniRef50_A1UEI9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 128 3e-28
UniRef50_Q8UJZ6 Cluster: Phosphoglycerate dehydrogenase; n=3; Al... 128 4e-28
UniRef50_A5ZQ76 Cluster: Putative uncharacterized protein; n=2; ... 128 4e-28
UniRef50_Q7WEA3 Cluster: Phosphoglycerate dehydrogenase; n=1; Bo... 127 6e-28
UniRef50_Q2RTD0 Cluster: Glycolate reductase; n=8; Alphaproteoba... 127 6e-28
UniRef50_A1HQU2 Cluster: Glyoxylate reductase; n=1; Thermosinus ... 127 6e-28
UniRef50_UPI0000DB72A4 Cluster: PREDICTED: similar to 3-phosphog... 127 7e-28
UniRef50_Q98LH4 Cluster: Phosphoglycerate dehydrogenase; n=3; Me... 127 7e-28
UniRef50_Q896Z8 Cluster: 2-hydroxyacid dehydrogenase; n=4; Clost... 127 7e-28
UniRef50_Q3DL54 Cluster: Glyoxylate reductase, NADH-dependent; n... 127 7e-28
UniRef50_Q3CIY1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 127 7e-28
UniRef50_Q9HVG5 Cluster: Glycerate dehydrogenase; n=23; Gammapro... 126 1e-27
UniRef50_Q49ZM5 Cluster: Putative dehydrogenase; n=1; Staphyloco... 126 1e-27
UniRef50_A1FGW0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 126 1e-27
UniRef50_Q0W672 Cluster: Glycerate dehydrogenase; n=2; Archaea|R... 126 1e-27
UniRef50_Q82W00 Cluster: D-isomer specific 2-hydroxyacid dehydro... 126 1e-27
UniRef50_Q6RK69 Cluster: D-lactate dehydrogenase; n=1; Lactobaci... 126 1e-27
UniRef50_O43175 Cluster: D-3-phosphoglycerate dehydrogenase; n=5... 126 1e-27
UniRef50_A5ZA39 Cluster: Putative uncharacterized protein; n=1; ... 126 2e-27
UniRef50_A0FZA8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 126 2e-27
UniRef50_P45250 Cluster: Putative 2-hydroxyacid dehydrogenase HI... 126 2e-27
UniRef50_Q82XY9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 125 2e-27
UniRef50_Q7MV92 Cluster: Glycerate dehydrogenase; n=1; Porphyrom... 125 3e-27
UniRef50_Q2BHH2 Cluster: Glycerate dehydrogenase; n=1; Neptuniib... 125 3e-27
UniRef50_O28495 Cluster: 2-hydroxyacid dehydrogenase, putative; ... 125 3e-27
UniRef50_A0RW58 Cluster: Phosphoglycerate dehydrogenase; n=3; Cr... 125 3e-27
UniRef50_O32264 Cluster: Probable 2-ketogluconate reductase; n=1... 125 3e-27
UniRef50_Q1MPI0 Cluster: Lactate dehydrogenase and related dehyd... 124 4e-27
UniRef50_Q11SX0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 124 4e-27
UniRef50_Q0FY56 Cluster: Putative phosphoglycerate dehydrogenase... 124 4e-27
UniRef50_O04130 Cluster: D-3-phosphoglycerate dehydrogenase, chl... 124 4e-27
UniRef50_Q88YI0 Cluster: Phosphoglycerate dehydrogenase; n=5; Ba... 124 5e-27
UniRef50_Q5LT44 Cluster: D-isomer specific 2-hydroxyacid dehydro... 124 5e-27
UniRef50_Q5U922 Cluster: (R)-2-hydroxyisocaproate dehydrogenase;... 124 5e-27
UniRef50_A7NGZ0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 124 5e-27
UniRef50_A6GPV1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 124 5e-27
UniRef50_Q9LMM9 Cluster: F22L4.6 protein; n=22; core eudicotyled... 124 5e-27
UniRef50_Q9RUU0 Cluster: D-3-phosphoglycerate dehydrogenase; n=4... 124 7e-27
UniRef50_A7FYM9 Cluster: D-lactate dehydrogenase; n=4; Clostridi... 124 7e-27
UniRef50_A4ARG6 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 124 7e-27
UniRef50_Q8TR50 Cluster: Glycerate dehydrogenase; n=2; Methanosa... 124 7e-27
UniRef50_Q8R8Q2 Cluster: Lactate dehydrogenase and related dehyd... 123 9e-27
UniRef50_A1HM37 Cluster: D-isomer specific 2-hydroxyacid dehydro... 123 9e-27
UniRef50_Q6MY49 Cluster: NAD-dependant D-isomer specific 2-hydro... 123 9e-27
UniRef50_Q7WM64 Cluster: Putative dehydrogenase; n=2; Bordetella... 123 1e-26
UniRef50_Q1NQ97 Cluster: D-isomer specific 2-hydroxyacid dehydro... 123 1e-26
UniRef50_A7CY19 Cluster: D-isomer specific 2-hydroxyacid dehydro... 123 1e-26
UniRef50_A6Q7Q2 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 123 1e-26
UniRef50_A7STU0 Cluster: Predicted protein; n=5; Nematostella ve... 123 1e-26
UniRef50_P30799 Cluster: 2-hydroxyacid dehydrogenase homolog; n=... 123 1e-26
UniRef50_Q5FUW5 Cluster: D-3-phosphoglycerate dehydrogenase; n=5... 122 2e-26
UniRef50_Q0S7S0 Cluster: Probable phosphoglycerate dehydrogenase... 122 2e-26
UniRef50_Q5KQ73 Cluster: D-3-phosphoglycerate dehydrogenase, put... 122 2e-26
UniRef50_Q65WI5 Cluster: SerA protein; n=1; Mannheimia succinici... 122 2e-26
UniRef50_A1RC54 Cluster: Glyoxylate reductase; n=2; Actinomyceta... 122 2e-26
UniRef50_Q6BTY7 Cluster: Debaryomyces hansenii chromosome C of s... 122 2e-26
UniRef50_A7AAD2 Cluster: Putative uncharacterized protein; n=1; ... 122 3e-26
UniRef50_A5ZAS1 Cluster: Putative uncharacterized protein; n=1; ... 122 3e-26
UniRef50_A0L7J1 Cluster: D-3-phosphoglycerate dehydrogenase; n=3... 122 3e-26
UniRef50_Q2LUG0 Cluster: 2-hydroxyacid dehydrogenase, D-isomer s... 121 4e-26
UniRef50_Q7XAP0 Cluster: C-terminal binding protein; n=3; Marcha... 121 4e-26
UniRef50_A7EUN0 Cluster: Formate dehydrogenase; n=2; Sclerotinia... 121 4e-26
UniRef50_Q3IFC5 Cluster: 2-hydroxyacid dehydrogenase family prot... 121 5e-26
UniRef50_Q4PER7 Cluster: Putative uncharacterized protein; n=1; ... 121 5e-26
UniRef50_Q6LYW5 Cluster: 2-hydroxyacid dehydrogenase, D-isomer s... 121 5e-26
UniRef50_Q1DT79 Cluster: Putative uncharacterized protein; n=1; ... 120 7e-26
UniRef50_Q0V2B9 Cluster: Putative uncharacterized protein; n=1; ... 120 7e-26
UniRef50_A7HEG1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 120 9e-26
UniRef50_A4WXD4 Cluster: Dimethylmenaquinone methyltransferase; ... 120 9e-26
UniRef50_Q7D366 Cluster: AGR_pAT_578p; n=2; Agrobacterium tumefa... 120 1e-25
UniRef50_A6LZ51 Cluster: D-isomer specific 2-hydroxyacid dehydro... 120 1e-25
UniRef50_A0JWH0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 120 1e-25
UniRef50_A7P9P5 Cluster: Chromosome chr3 scaffold_8, whole genom... 120 1e-25
UniRef50_Q88VJ2 Cluster: D-lactate dehydrogenase; n=27; Lactobac... 120 1e-25
UniRef50_Q59516 Cluster: Glycerate dehydrogenase; n=23; Proteoba... 120 1e-25
UniRef50_Q89388 Cluster: A53R protein; n=3; Chlorovirus|Rep: A53... 119 2e-25
UniRef50_Q30V14 Cluster: D-isomer specific 2-hydroxyacid dehydro... 119 2e-25
UniRef50_O83080 Cluster: D-lactate dehydrogenase; n=1; Treponema... 119 2e-25
UniRef50_UPI000023F60F Cluster: hypothetical protein FG08018.1; ... 119 2e-25
UniRef50_Q0HS14 Cluster: D-isomer specific 2-hydroxyacid dehydro... 119 2e-25
UniRef50_Q04DF1 Cluster: Lactate dehydrogenase related enzyme; n... 119 2e-25
UniRef50_A6BZW2 Cluster: Putative dehydrogenase; n=1; Planctomyc... 119 2e-25
UniRef50_Q0CUD5 Cluster: Putative uncharacterized protein; n=1; ... 119 2e-25
UniRef50_A0RUD3 Cluster: 2 lactate dehydrogenase; n=2; Thermopro... 119 2e-25
UniRef50_Q8EP33 Cluster: Glycerate dehydrogenase; n=2; Bacillace... 118 3e-25
UniRef50_Q88YA7 Cluster: Bifunctional protein: amino acid aminot... 118 3e-25
UniRef50_Q73M93 Cluster: Glycerate dehydrogenase; n=3; Bacteria|... 118 3e-25
UniRef50_Q21A61 Cluster: D-isomer specific 2-hydroxyacid dehydro... 118 3e-25
UniRef50_Q12CS0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 118 3e-25
UniRef50_Q126V3 Cluster: D-isomer specific 2-hydroxyacid dehydro... 118 3e-25
UniRef50_Q0K073 Cluster: D-3-Phosphoglycerate dehydrogenase; n=2... 118 3e-25
UniRef50_A1IDH6 Cluster: D-3-phosphoglycerate dehydrogenase; n=3... 118 3e-25
UniRef50_P58220 Cluster: 2-ketogluconate reductase; n=75; Proteo... 118 3e-25
UniRef50_UPI0000384B5F Cluster: COG0111: Phosphoglycerate dehydr... 118 3e-25
UniRef50_Q7M7Q8 Cluster: PUTATIVE D-2-HYDROXYACID DEHYDROGENASE;... 118 3e-25
UniRef50_A7IJ69 Cluster: D-isomer specific 2-hydroxyacid dehydro... 118 3e-25
UniRef50_A4TXP1 Cluster: Glycolate reductase; n=1; Magnetospiril... 118 3e-25
UniRef50_Q0J5C2 Cluster: Os08g0447000 protein; n=11; Viridiplant... 118 3e-25
UniRef50_P53839 Cluster: Putative 2-hydroxyacid dehydrogenase YN... 118 3e-25
UniRef50_Q893I3 Cluster: D-lactate dehydrogenase; n=2; Firmicute... 118 5e-25
UniRef50_Q1FLB8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 118 5e-25
UniRef50_Q0B1Q1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 118 5e-25
UniRef50_A3IA61 Cluster: D-3 phosphoglycerate dehydrogenase; n=1... 118 5e-25
UniRef50_A0Q8P3 Cluster: D-isomer specific 2-hydroxyacid dehydro... 118 5e-25
UniRef50_A7SFV8 Cluster: Predicted protein; n=1; Nematostella ve... 118 5e-25
UniRef50_Q8XN08 Cluster: D-lactate dehydrogenase; n=4; Firmicute... 117 6e-25
UniRef50_Q6FFP8 Cluster: Putative 2-hydroxyacid dehydrogenase; n... 117 6e-25
UniRef50_A5ZAJ9 Cluster: Putative uncharacterized protein; n=1; ... 117 6e-25
UniRef50_A4BI79 Cluster: D-lactate dehydrogenase; n=1; Reinekea ... 117 6e-25
UniRef50_Q03XJ7 Cluster: 2-hydroxyacid dehydrogenase; n=3; Lacto... 117 8e-25
UniRef50_Q1E5G6 Cluster: Putative uncharacterized protein; n=1; ... 117 8e-25
UniRef50_Q97IU7 Cluster: Lactate dehydrogenase; n=5; Clostridial... 116 1e-24
UniRef50_A4FK85 Cluster: D-3-phosphoglycerate dehydrogenase, put... 116 1e-24
UniRef50_A3RV54 Cluster: 2-hydroxyacid dehydrogenase; n=5; Burkh... 116 1e-24
UniRef50_UPI000023E18D Cluster: hypothetical protein FG04024.1; ... 116 1e-24
UniRef50_Q97N23 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 116 1e-24
UniRef50_Q1K3M3 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 116 1e-24
UniRef50_A5N5A9 Cluster: SerA; n=1; Clostridium kluyveri DSM 555... 116 1e-24
UniRef50_Q825H6 Cluster: Putative glycerate dehydrogenase; n=1; ... 116 2e-24
UniRef50_Q0C254 Cluster: D-isomer specific 2-hydroxyacid dehydro... 116 2e-24
UniRef50_A1HSQ7 Cluster: D-isomer specific 2-hydroxyacid dehydro... 116 2e-24
UniRef50_Q8RG31 Cluster: 2-hydroxyglutarate dehydrogenase; n=4; ... 115 2e-24
UniRef50_Q47W88 Cluster: D-isomer specific 2-hydroxyacid dehydro... 115 2e-24
UniRef50_A0VQR0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 115 2e-24
UniRef50_Q8ZXX8 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 115 2e-24
UniRef50_Q2LGV1 Cluster: Phosphoglycerate dehydrogenase; n=6; Ha... 115 2e-24
UniRef50_A4FIJ9 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 115 3e-24
UniRef50_Q5K657 Cluster: Hydroxyacid dehydrogenase protein Ynl27... 115 3e-24
UniRef50_Q0TYA3 Cluster: Putative uncharacterized protein; n=2; ... 115 3e-24
UniRef50_UPI000050F9E4 Cluster: COG0111: Phosphoglycerate dehydr... 114 4e-24
UniRef50_A4YUP8 Cluster: Putative D-3-phosphoglycerate dehydroge... 114 4e-24
UniRef50_A4BPX8 Cluster: Glycerate dehydrogenase; n=1; Nitrococc... 114 4e-24
UniRef50_A1ZX42 Cluster: Glycerate dehydrogenase; n=1; Microscil... 114 4e-24
UniRef50_Q9TXJ5 Cluster: D-3-phosphoglycerate dehydrogenase-like... 114 4e-24
UniRef50_A7CR80 Cluster: D-isomer specific 2-hydroxyacid dehydro... 114 6e-24
UniRef50_A4AL46 Cluster: Putative dehydrogenase; n=1; marine act... 114 6e-24
UniRef50_A2QX18 Cluster: Contig An11c0250, complete genome; n=3;... 114 6e-24
UniRef50_Q0RXU8 Cluster: Phosphoglycerate dehydrogenase; n=1; Rh... 113 7e-24
UniRef50_A0GVM6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 113 7e-24
UniRef50_Q8ZTC7 Cluster: D-3-phosphoglycerate dehydrogenase; n=5... 113 7e-24
UniRef50_A4TF35 Cluster: D-isomer specific 2-hydroxyacid dehydro... 113 1e-23
UniRef50_Q752A0 Cluster: AFR675Wp; n=3; Saccharomycetales|Rep: A... 113 1e-23
UniRef50_A1CFW0 Cluster: D-mandelate dehydrogenase, putative; n=... 113 1e-23
UniRef50_A0HBX6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 113 1e-23
UniRef50_Q5KJK5 Cluster: Glycerate-and formate-dehydrogenase, pu... 113 1e-23
UniRef50_Q9HK29 Cluster: 2-hydroxyacid dehydrogenase related pro... 113 1e-23
UniRef50_UPI000023F11E Cluster: hypothetical protein FG10680.1; ... 112 2e-23
UniRef50_Q6NUX3 Cluster: Im:7137941 protein; n=3; Danio rerio|Re... 112 2e-23
UniRef50_Q83AZ4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 112 2e-23
UniRef50_Q5HW94 Cluster: D-isomer specific 2-hydroxyacid dehydro... 112 2e-23
UniRef50_Q1FF19 Cluster: D-isomer specific 2-hydroxyacid dehydro... 112 2e-23
UniRef50_A0Z2L3 Cluster: Putative uncharacterized protein; n=1; ... 112 2e-23
UniRef50_Q00TL2 Cluster: D-isomer specific 2-hydroxyacid dehydro... 112 2e-23
UniRef50_Q5KKI9 Cluster: 2-hydroxyacid dehydrogenase, putative; ... 112 2e-23
UniRef50_Q5WAF3 Cluster: 2-ketogluconate reductase; n=1; Bacillu... 112 2e-23
UniRef50_A6G5P3 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 112 2e-23
UniRef50_A5WBM9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 112 2e-23
UniRef50_A1RMU0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 112 2e-23
UniRef50_Q7Z019 Cluster: Putative D-lactate dehydrogenase; n=1; ... 112 2e-23
UniRef50_A4FHH0 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 111 3e-23
UniRef50_A4AQJ2 Cluster: D-lactate dehydrogenase; n=1; Flavobact... 111 3e-23
UniRef50_Q54UF7 Cluster: Putative uncharacterized protein; n=1; ... 111 3e-23
UniRef50_Q7NEV2 Cluster: Phosphoglycerate dehydrogenase; n=6; Ba... 111 4e-23
UniRef50_Q0FF66 Cluster: Glycolate reductase; n=2; Alphaproteoba... 111 4e-23
UniRef50_A1AR04 Cluster: D-isomer specific 2-hydroxyacid dehydro... 111 4e-23
UniRef50_A0PVI8 Cluster: D-3-phosphoglycerate dehydrogenase SerA... 111 4e-23
UniRef50_Q27SN5 Cluster: Beta xylosidase-like protein; n=1; Acan... 111 4e-23
UniRef50_Q986P2 Cluster: Phosphoglycerate dehydrogenase; n=14; c... 111 5e-23
UniRef50_A3PPC6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 111 5e-23
UniRef50_Q98GE4 Cluster: Phosphoglycerate dehydrogenase; n=5; Rh... 110 7e-23
UniRef50_Q5IW39 Cluster: Putative PhpE; n=2; Actinomycetales|Rep... 110 7e-23
UniRef50_A6Q6K4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 110 7e-23
UniRef50_A6QZ02 Cluster: Predicted protein; n=2; Onygenales|Rep:... 110 7e-23
UniRef50_Q99ZM2 Cluster: D-lactate dehydrogenase; n=7; Streptoco... 110 7e-23
UniRef50_Q59642 Cluster: D-lactate dehydrogenase; n=5; Pediococc... 110 7e-23
UniRef50_Q62LV8 Cluster: Glyoxylate reductase; n=53; cellular or... 110 9e-23
UniRef50_A6T665 Cluster: Putative D-3-phosphoglycerate dehydroge... 110 9e-23
UniRef50_A5TSY9 Cluster: Possible dehydrogenase; n=1; Fusobacter... 110 9e-23
UniRef50_A4GXI6 Cluster: D-lactate dehydrogenase; n=2; Lactobaci... 110 9e-23
UniRef50_A0LN07 Cluster: D-isomer specific 2-hydroxyacid dehydro... 110 9e-23
UniRef50_A2F8V0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 110 9e-23
UniRef50_Q9HSS1 Cluster: Phosphoglycerate dehydrogenase; n=1; Ha... 110 9e-23
UniRef50_Q931A1 Cluster: Putative; n=2; Rhizobiales|Rep: Putativ... 109 1e-22
UniRef50_Q89LI6 Cluster: Blr4558 protein; n=6; Bradyrhizobiaceae... 109 1e-22
UniRef50_P17584 Cluster: D-2-hydroxyisocaproate dehydrogenase; n... 109 1e-22
UniRef50_Q5QU97 Cluster: 2-hydroxyacid dehydrogenase; n=4; Gamma... 109 2e-22
UniRef50_Q5FUD9 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 109 2e-22
UniRef50_A4S3N1 Cluster: Predicted protein; n=2; Ostreococcus|Re... 109 2e-22
UniRef50_Q7UQC8 Cluster: Probable 2-hydroxyacid dehydrogenase; n... 109 2e-22
UniRef50_Q4AIL7 Cluster: D-isomer specific 2-hydroxyacid dehydro... 109 2e-22
UniRef50_Q214B1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 109 2e-22
UniRef50_Q04AA8 Cluster: Lactate dehydrogenase related enzyme; n... 109 2e-22
UniRef50_Q036G7 Cluster: Lactate dehydrogenase related 2-hydroxy... 109 2e-22
UniRef50_A5V984 Cluster: D-isomer specific 2-hydroxyacid dehydro... 109 2e-22
UniRef50_P33160 Cluster: Formate dehydrogenase; n=54; cellular o... 109 2e-22
UniRef50_A5TUT7 Cluster: Dehydrogenase; n=4; Fusobacterium nucle... 108 3e-22
UniRef50_A3UGW9 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 108 3e-22
UniRef50_Q8YK31 Cluster: Glycerate dehydrogenase; n=3; Cyanobact... 108 4e-22
UniRef50_Q8G427 Cluster: Possible 2-hydroxyacid dehydrogenase; n... 107 5e-22
UniRef50_Q6MIG3 Cluster: Hxdroxypyruvate reductase; n=1; Bdellov... 107 5e-22
UniRef50_Q579J7 Cluster: D-isomer specific 2-hydroxyacid dehydro... 107 5e-22
UniRef50_Q03U10 Cluster: 2-hydroxyacid dehydrogenase; n=1; Lacto... 107 5e-22
UniRef50_A5G0Z0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 107 5e-22
UniRef50_A3JX80 Cluster: D-isomer specific 2-hydroxyacid dehydro... 107 5e-22
UniRef50_Q81K70 Cluster: D-isomer specific 2-hydroxyacid dehydro... 107 6e-22
UniRef50_Q6FCL4 Cluster: 2-keto-D-gluconate reductase; n=15; Pse... 107 6e-22
UniRef50_Q03YV3 Cluster: Lactate dehydrogenase related enzyme; n... 107 6e-22
UniRef50_Q0FUK3 Cluster: Predicted dehydrogenase; n=3; Rhodobact... 107 9e-22
UniRef50_Q89QF5 Cluster: Blr3173 protein; n=3; Bradyrhizobium|Re... 106 1e-21
UniRef50_Q12E23 Cluster: D-isomer specific 2-hydroxyacid dehydro... 106 1e-21
UniRef50_Q11QU3 Cluster: D-lactate dehydrogenase; n=1; Cytophaga... 106 1e-21
UniRef50_A3XKE7 Cluster: D-lactate dehydrogenase; n=3; Bacteria|... 106 1e-21
UniRef50_Q4SJ39 Cluster: Chromosome 21 SCAF14577, whole genome s... 106 1e-21
UniRef50_Q44NM9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 106 1e-21
UniRef50_Q1LCR9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 106 1e-21
UniRef50_A7UH56 Cluster: Putative 2-hydroxy acid dehydrogenase; ... 106 1e-21
UniRef50_A6PUG1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 106 1e-21
UniRef50_A5Z3X2 Cluster: Putative uncharacterized protein; n=1; ... 106 1e-21
UniRef50_A4SWE6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 106 1e-21
UniRef50_Q5KN70 Cluster: D-3-phosphoglycerate dehydrogenase 2, p... 106 1e-21
UniRef50_Q8UBA7 Cluster: 2-hydroxyacid-family dehydrogenase; n=5... 105 2e-21
UniRef50_Q8CPW2 Cluster: Glycerate dehydrogenase; n=4; Staphyloc... 105 3e-21
UniRef50_Q0V699 Cluster: Putative uncharacterized protein; n=2; ... 105 3e-21
UniRef50_O14075 Cluster: Putative 2-hydroxyacid dehydrogenase UN... 105 3e-21
UniRef50_Q03WU1 Cluster: Lactate dehydrogenase related dehydroge... 105 3e-21
UniRef50_A6EBH4 Cluster: Phosphoglycerate dehydrogenase; n=1; Pe... 105 3e-21
UniRef50_A5V6T9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 105 3e-21
UniRef50_Q9BLF6 Cluster: D-lactate dehydrogenase; n=1; Octopus v... 105 3e-21
UniRef50_P40054 Cluster: D-3-phosphoglycerate dehydrogenase 1; n... 105 3e-21
UniRef50_P72357 Cluster: D-lactate dehydrogenase; n=28; Bacilli|... 105 3e-21
UniRef50_A0YEL9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 104 5e-21
UniRef50_Q4FNZ3 Cluster: Probable dehydrogenase; n=2; Candidatus... 104 6e-21
UniRef50_Q1MQK2 Cluster: Phosphoglycerate dehydrogenase and rela... 104 6e-21
UniRef50_Q191U4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 104 6e-21
UniRef50_A0NLL6 Cluster: Glycerate dehydrogenase; n=1; Stappia a... 104 6e-21
UniRef50_Q89Y67 Cluster: Oxidoreductase; n=14; Alphaproteobacter... 103 8e-21
UniRef50_Q14L30 Cluster: Hypothetical d-lactate dehydrogenase pr... 103 8e-21
UniRef50_Q120R1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 103 8e-21
UniRef50_A5VE25 Cluster: D-isomer specific 2-hydroxyacid dehydro... 103 8e-21
UniRef50_Q1E2M0 Cluster: Putative uncharacterized protein; n=3; ... 103 8e-21
UniRef50_A5YST2 Cluster: Phosphoglycerate dehydrogenase; n=2; Ha... 103 1e-20
UniRef50_Q81N95 Cluster: D-3-phosphoglycerate dehydrogenase, put... 103 1e-20
UniRef50_Q65DI9 Cluster: YoaD; n=1; Bacillus licheniformis ATCC ... 103 1e-20
UniRef50_Q1WVK4 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 103 1e-20
UniRef50_Q031D4 Cluster: Phosphoglycerate dehydrogenase; n=20; S... 103 1e-20
UniRef50_A0R5A8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 103 1e-20
UniRef50_Q9LE33 Cluster: T12C24.9; n=6; core eudicotyledons|Rep:... 103 1e-20
UniRef50_A6QVW0 Cluster: Putative uncharacterized protein; n=1; ... 103 1e-20
UniRef50_A6VXE9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 102 2e-20
UniRef50_Q22CX9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 102 2e-20
UniRef50_Q12VM6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 102 2e-20
UniRef50_Q39LG4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 102 2e-20
UniRef50_Q125T3 Cluster: D-isomer specific 2-hydroxyacid dehydro... 102 2e-20
UniRef50_A6PPS4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 102 2e-20
UniRef50_A0Z6W9 Cluster: Spermidine/putrescine ABC transporter A... 102 2e-20
UniRef50_Q9A6E7 Cluster: D-isomer specific 2-hydroxyacid dehydro... 101 3e-20
UniRef50_Q7X388 Cluster: Phosphoglycerate dehydrogenase; n=3; Es... 101 3e-20
UniRef50_A0JVX0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 101 3e-20
UniRef50_A0AFI6 Cluster: Complete genome; n=1; Listeria welshime... 101 3e-20
UniRef50_Q97ZK1 Cluster: D-3-phosphoglycerate dehydrogenase; n=4... 101 3e-20
UniRef50_Q8EMJ4 Cluster: 2-ketogluconate reductase; n=1; Oceanob... 101 4e-20
UniRef50_Q397E0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 101 4e-20
UniRef50_O86322 Cluster: POSSIBLE D-3-PHOSPHOGLYCERATE DEHYDROGE... 101 4e-20
UniRef50_A5UPU9 Cluster: Glyoxylate reductase; n=12; Bacteria|Re... 101 4e-20
UniRef50_A0GDF1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 101 4e-20
UniRef50_P36234 Cluster: Glycerate dehydrogenase; n=2; Hyphomicr... 101 4e-20
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 101 6e-20
UniRef50_Q67M77 Cluster: Phosphoglycerate dehydrogenase, C-termi... 101 6e-20
UniRef50_Q140F4 Cluster: Putative D-3-phosphoglycerate dehydroge... 101 6e-20
UniRef50_A1W7E2 Cluster: D-isomer specific 2-hydroxyacid dehydro... 101 6e-20
UniRef50_A1JTE6 Cluster: Putative oxidoreductase; n=1; Yersinia ... 101 6e-20
UniRef50_Q9NSY3 Cluster: Putative uncharacterized protein DKFZp4... 101 6e-20
UniRef50_Q47748 Cluster: D-specific alpha-keto acid dehydrogenas... 101 6e-20
UniRef50_Q8GQX5 Cluster: 2-oxo-4-phenylbutanoate reductase; n=2;... 100 7e-20
UniRef50_A2A023 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 100 7e-20
UniRef50_Q8Y3L1 Cluster: Lmo2824 protein; n=14; Bacillales|Rep: ... 100 1e-19
UniRef50_Q88ZU6 Cluster: Phosphoglycerate dehydrogenase; n=2; La... 100 1e-19
UniRef50_Q82ZC3 Cluster: D-isomer specific 2-hydroxyacid dehydro... 100 1e-19
UniRef50_Q7P6Z0 Cluster: D-lactate dehydrogenase; n=10; Bacteria... 100 1e-19
UniRef50_Q6KZ29 Cluster: Gluconate 2-dehydrogenase; n=3; Archaea... 100 1e-19
UniRef50_Q5HL54 Cluster: D-isomer specific 2-hydroxyacid dehydro... 99 1e-19
UniRef50_Q1GJ08 Cluster: D-isomer specific 2-hydroxyacid dehydro... 100 2e-19
UniRef50_Q9RK40 Cluster: Putative dehydrogenase; n=1; Streptomyc... 99 2e-19
UniRef50_Q8XPB1 Cluster: D-3-phosphoglycerate dehydrogenase; n=3... 99 2e-19
UniRef50_Q27SS3 Cluster: Glycerate dehydrogenase-like protein; n... 99 2e-19
UniRef50_Q883D2 Cluster: D-isomer specific 2-hydroxyacid dehydro... 99 3e-19
UniRef50_Q6CDS0 Cluster: Similar to tr|O94020 Candida albicans Y... 99 3e-19
UniRef50_A7I9X3 Cluster: D-isomer specific 2-hydroxyacid dehydro... 99 3e-19
UniRef50_UPI0000586D88 Cluster: PREDICTED: hypothetical protein,... 98 4e-19
UniRef50_Q9S2M5 Cluster: Putative D-lactate dehydrogenase; n=1; ... 98 4e-19
UniRef50_Q63YS2 Cluster: D-isomer specific 2-hydroxyacid dehydro... 98 4e-19
UniRef50_A5N6P2 Cluster: GyaR; n=1; Clostridium kluyveri DSM 555... 98 4e-19
UniRef50_A5IXT8 Cluster: D-lactate dehydrogenase; n=3; Mycoplasm... 98 4e-19
UniRef50_Q8X0E6 Cluster: Related to D-mandelate dehydrogenase; n... 98 4e-19
UniRef50_A4RX85 Cluster: Predicted protein; n=3; Ostreococcus|Re... 98 5e-19
UniRef50_A5P5Y8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 97 7e-19
UniRef50_Q2UDC2 Cluster: Glyoxylate/hydroxypyruvate reductase; n... 97 7e-19
UniRef50_UPI0000E4762C Cluster: PREDICTED: similar to D-3-phosph... 97 9e-19
UniRef50_Q1M7M0 Cluster: Putative 2-hydroxyacid dehydrogenase; n... 97 9e-19
UniRef50_A3VA29 Cluster: D-isomer specific 2-hydroxyacid dehydro... 97 9e-19
UniRef50_A2FHI8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 97 9e-19
UniRef50_Q981W5 Cluster: Phosphoglycerate dehydrogenase; n=1; Me... 97 1e-18
UniRef50_Q8MR05 Cluster: LD48009p; n=11; Coelomata|Rep: LD48009p... 97 1e-18
UniRef50_P0A9T3 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 97 1e-18
UniRef50_Q82XE1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 96 2e-18
UniRef50_A1WHT1 Cluster: D-isomer specific 2-hydroxyacid dehydro... 96 2e-18
UniRef50_Q76KF6 Cluster: D-glycerate dehydrogenase; n=4; Entamoe... 96 2e-18
UniRef50_O94574 Cluster: Putative 2-hydroxyacid dehydrogenase C1... 96 2e-18
UniRef50_Q63VJ5 Cluster: D-3-phosphoglycerate dehydrogenase; n=8... 96 2e-18
UniRef50_Q1FJY2 Cluster: D-isomer specific 2-hydroxyacid dehydro... 96 2e-18
UniRef50_Q11BV4 Cluster: D-isomer specific 2-hydroxyacid dehydro... 96 2e-18
UniRef50_Q48534 Cluster: D-hydroxyisocaproate dehydrogenase; n=6... 95 3e-18
UniRef50_A6DQ00 Cluster: SerA; n=1; Lentisphaera araneosa HTCC21... 95 3e-18
UniRef50_A3PDQ1 Cluster: Putative dehydrogenase; n=1; Prochloroc... 95 3e-18
UniRef50_Q8LL97 Cluster: Putative uncharacterized protein; n=1; ... 95 3e-18
UniRef50_Q11UL6 Cluster: Phosphoglycerate dehydrogenase; n=1; Cy... 95 4e-18
UniRef50_A4AN91 Cluster: Predicted dehydrogenase; n=14; Bacteroi... 95 4e-18
UniRef50_A7S382 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ... 95 4e-18
UniRef50_Q3SK87 Cluster: D-isomer specific 2-hydroxyacid dehydro... 95 5e-18
UniRef50_Q3KAR6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 95 5e-18
UniRef50_A7BQE7 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 95 5e-18
UniRef50_Q5ZYW9 Cluster: D-3-phosphoglycerate dehydrogenase; n=3... 94 6e-18
UniRef50_Q49UN3 Cluster: NAD-dependent formate dehydrogenase; n=... 94 6e-18
UniRef50_Q1V097 Cluster: Phosphoglycerate dehydrogenase; n=2; Ca... 94 6e-18
UniRef50_A4AK07 Cluster: Glycerate dehydrogenase; n=1; marine ac... 94 6e-18
UniRef50_Q5KLD5 Cluster: Oxidoreductase, putative; n=2; Filobasi... 94 6e-18
UniRef50_Q4WHR3 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 94 6e-18
UniRef50_Q1R7K3 Cluster: 2-hydroxyacid dehydrogenase; n=7; Enter... 94 9e-18
UniRef50_A7HWK6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 94 9e-18
UniRef50_Q6L245 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 94 9e-18
UniRef50_Q8U6W5 Cluster: 2-hydroxyacid dehydrogenase; n=3; Alpha... 93 1e-17
UniRef50_A5IAP7 Cluster: D-isomer specific 2-hydroxyacid dehydro... 93 1e-17
UniRef50_Q89F87 Cluster: Bll6814 protein; n=9; Bradyrhizobiaceae... 93 1e-17
UniRef50_Q5KKJ8 Cluster: Glyoxylate reductase, putative; n=2; Fi... 93 1e-17
UniRef50_Q89J71 Cluster: 2-hydroxyacid dehydrogenase; n=8; Brady... 93 2e-17
UniRef50_A0QVE9 Cluster: Glyoxylate reductase; n=1; Mycobacteriu... 93 2e-17
UniRef50_Q0UHH1 Cluster: Putative uncharacterized protein; n=1; ... 93 2e-17
UniRef50_A7F383 Cluster: Putative uncharacterized protein; n=1; ... 93 2e-17
UniRef50_Q97FN7 Cluster: D-lactate dehydrogenase; n=1; Clostridi... 92 3e-17
UniRef50_Q3KE30 Cluster: D-isomer specific 2-hydroxyacid dehydro... 92 3e-17
UniRef50_A1WAF9 Cluster: D-isomer specific 2-hydroxyacid dehydro... 92 3e-17
UniRef50_UPI0000EBEEB9 Cluster: PREDICTED: similar to C-terminal... 92 3e-17
UniRef50_Q3A6W9 Cluster: 3-phosphoglycerate dehydrogenase; n=1; ... 92 3e-17
UniRef50_Q03UK9 Cluster: Lactate dehydrogenase; n=3; Leuconostoc... 92 3e-17
UniRef50_A4U158 Cluster: D-isomer specific 2-hydroxyacid dehydro... 92 3e-17
UniRef50_A4SW26 Cluster: D-isomer specific 2-hydroxyacid dehydro... 92 3e-17
UniRef50_A4EAR0 Cluster: Putative uncharacterized protein; n=1; ... 92 3e-17
UniRef50_UPI0000DC0E13 Cluster: 3-phosphoglycerate dehydrogenase... 91 5e-17
UniRef50_Q3S8E5 Cluster: Putative D-isomer specific 2-hydroxyaci... 91 5e-17
UniRef50_Q047V3 Cluster: Lactate dehydrogenase related 2-hydroxy... 91 5e-17
UniRef50_A6UCB8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 91 5e-17
UniRef50_Q6IP95 Cluster: CTBP1 protein; n=2; Homo sapiens|Rep: C... 91 5e-17
UniRef50_Q8F5N8 Cluster: Phosphoglycerate dehydrogenase; n=4; Le... 91 6e-17
UniRef50_Q5NR73 Cluster: 2-hydroxyacid dehydrogenase; n=1; Zymom... 91 6e-17
UniRef50_Q5LQR6 Cluster: D-isomer specific 2-hydroxyacid dehydro... 91 8e-17
UniRef50_A4GXJ1 Cluster: D-lactate dehydrogenase; n=4; Lactobaci... 91 8e-17
UniRef50_A2ZQX8 Cluster: Putative uncharacterized protein; n=1; ... 91 8e-17
UniRef50_A1S0J0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 91 8e-17
UniRef50_O69054 Cluster: Phosphonate dehydrogenase; n=16; Bacter... 91 8e-17
UniRef50_Q08911 Cluster: Formate dehydrogenase 1; n=71; Eukaryot... 90 1e-16
UniRef50_UPI0000587CB1 Cluster: PREDICTED: hypothetical protein;... 90 1e-16
UniRef50_Q2KZD5 Cluster: Putative reductase precursor; n=1; Bord... 90 1e-16
UniRef50_Q03Z77 Cluster: Lactate dehydrogenase related 2-hydroxy... 90 1e-16
UniRef50_Q7PMI6 Cluster: ENSANGP00000021069; n=1; Anopheles gamb... 90 1e-16
UniRef50_Q9RJW2 Cluster: Possible 2-hydroxyacid-family dehydroge... 89 2e-16
UniRef50_Q120Q8 Cluster: D-isomer specific 2-hydroxyacid dehydro... 89 2e-16
UniRef50_Q4PP80 Cluster: Putative glyoxylate reductase/hydroxypy... 89 2e-16
UniRef50_A7D498 Cluster: D-isomer specific 2-hydroxyacid dehydro... 89 2e-16
UniRef50_Q9UBQ7 Cluster: Glyoxylate reductase/hydroxypyruvate re... 89 2e-16
UniRef50_Q6A895 Cluster: D-3-phosphoglycerate dehydrogenase; n=2... 89 2e-16
UniRef50_O34815 Cluster: YoaD; n=2; Bacillus|Rep: YoaD - Bacillu... 89 3e-16
UniRef50_Q4IV69 Cluster: D-isomer specific 2-hydroxyacid dehydro... 89 3e-16
UniRef50_Q1VRN5 Cluster: D-3-phosphoglycerate dehydrogenase; n=1... 89 3e-16
UniRef50_Q11JF3 Cluster: D-isomer specific 2-hydroxyacid dehydro... 88 4e-16
UniRef50_Q01W77 Cluster: D-isomer specific 2-hydroxyacid dehydro... 88 4e-16
>UniRef50_Q5BU19 Cluster: Ribeye a protein; n=4; Clupeocephala|Rep:
Ribeye a protein - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 1147
Score = 536 bits (1323), Expect = e-151
Identities = 259/366 (70%), Positives = 298/366 (81%), Gaps = 26/366 (7%)
Query: 15 SMRGPIANGPLQSRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGA 74
S+R I NGP+ RPLVALLDGRDCTVEMPILKD+ATVAFCDAQST EIHEKVLNEAVGA
Sbjct: 763 SIRPQIMNGPMHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGA 822
Query: 75 LMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTM 134
+M+HTI LT+EDLEKFKALRII+RIGSG DNID+KAAGE+GIAVCN+P VEE AD+T+
Sbjct: 823 MMYHTITLTREDLEKFKALRIIIRIGSGYDNIDIKAAGEMGIAVCNIPSAAVEETADSTL 882
Query: 135 CLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRA 194
C ILNLYRR WL +REG + EQ+RE ++G ARIRG+TLG++G GR G AVA+RA
Sbjct: 883 CHILNLYRRNTWLYQAMREGTRVQSVEQIREVASGAARIRGETLGLIGFGRSGQAVAVRA 942
Query: 195 KAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIK 254
KAFGFNVIFYDPYL DG+E+SLG+ RVYTLQDLL+QSDCVSLHC+LNEHNHHLIN+FTIK
Sbjct: 943 KAFGFNVIFYDPYLQDGLERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIK 1002
Query: 255 QMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXX 314
QMR GAFLVNTARGGLVD++ LA ALK+GRIR AALDVHE+EPF+ Q
Sbjct: 1003 QMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFTQ------------ 1050
Query: 315 XXXXXXXCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCL 374
GPLKDAPNL+CTPH A+YS+ ++ E+RE AA+EIRRAI GRIPD L
Sbjct: 1051 --------------GPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPDSL 1096
Query: 375 RNCVNK 380
RNCVNK
Sbjct: 1097 RNCVNK 1102
>UniRef50_P56545 Cluster: C-terminal-binding protein 2; n=98;
Coelomata|Rep: C-terminal-binding protein 2 - Homo
sapiens (Human)
Length = 445
Score = 535 bits (1320), Expect = e-150
Identities = 264/384 (68%), Positives = 306/384 (79%), Gaps = 32/384 (8%)
Query: 1 MDKRKMLPKRARMD----SMRGPIANGPLQSRPLVALLDGRDCTVEMPILKDVATVAFCD 56
+DK K+ KR R+D +R I NGPL RPLVALLDGRDCTVEMPILKD+ATVAFCD
Sbjct: 4 VDKHKV--KRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCD 61
Query: 57 AQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGI 116
AQST EIHEKVLNEAVGA+M+HTI LT+EDLEKFKALR+IVRIGSG DN+D+KAAGELGI
Sbjct: 62 AQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGI 121
Query: 117 AVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGD 176
AVCN+P VEE AD+T+C ILNLYRR WL +REG + EQ+RE ++G ARIRG+
Sbjct: 122 AVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGE 181
Query: 177 TLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSL 236
TLG++G GR G AVA+RAKAFGF+VIFYDPYL DGIE+SLG+ RVYTLQDLL+QSDCVSL
Sbjct: 182 TLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSL 241
Query: 237 HCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
HC+LNEHNHHLIN+FTIKQMR GAFLVN ARGGLVD++ LA ALK+GRIR AALDVHE+E
Sbjct: 242 HCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESE 301
Query: 297 PFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELRE 356
PF+ Q GPLKDAPNL+CTPH A+YS+ ++ E+RE
Sbjct: 302 PFSFAQ--------------------------GPLKDAPNLICTPHTAWYSEQASLEMRE 335
Query: 357 MAASEIRRAIVGRIPDCLRNCVNK 380
AA+EIRRAI GRIP+ LRNCVNK
Sbjct: 336 AAATEIRRAITGRIPESLRNCVNK 359
>UniRef50_Q4S2R7 Cluster: Chromosome 17 SCAF14760, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 17 SCAF14760, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 634
Score = 411 bits (1011), Expect = e-113
Identities = 228/396 (57%), Positives = 265/396 (66%), Gaps = 45/396 (11%)
Query: 28 RPLVALLDGRDCTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDL 87
RPLVALLDGRDCTVEMPILKD+ATVAFCDAQST EIHEKVLNEAVGA+M+HTI LT+EDL
Sbjct: 159 RPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDL 218
Query: 88 EKFKALRIIVRIGSGVDNIDVKAAGELG-----------IAVCNVPGYGVEEVADTTMCL 136
EKFKALRII+RIGSG DNID+KAAGELG IAVCN+P VEE AD+T+C
Sbjct: 219 EKFKALRIIIRIGSGYDNIDIKAAGELGETGGMVGGGGGIAVCNIPSAAVEETADSTLCH 278
Query: 137 ILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIR---------GDTLGIVGL---- 183
ILNLYRR WL +REG + EQ+RE ++G ARIR G+ L VG
Sbjct: 279 ILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGELLVSVGWVTDA 338
Query: 184 ---------------GRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLL 228
GR G AVA+RAKAFGFNVIFYDPYL DG+E+SLG+ RVYTLQDLL
Sbjct: 339 VLFANSSPCPCPAPSGRSGQAVAMRAKAFGFNVIFYDPYLQDGLERSLGVQRVYTLQDLL 398
Query: 229 FQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFL----VNTARGGLVDDEGLAAALKQGR 284
+QSDCVSLHC+LNEHNHHLIN+FTIKQ G L + AR + + ++QG
Sbjct: 399 YQSDCVSLHCNLNEHNHHLINDFTIKQASSGLELRLLGLLEARPTWEETLVVHEKMRQGA 458
Query: 285 IRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCTPHAA 344
+ + + QA G S QGPLKDAPNL+CTPH A
Sbjct: 459 FLVNSARGGLVDEKALAQALKEGRIRGAALDVHESEPFS--FSQGPLKDAPNLICTPHTA 516
Query: 345 FYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNK 380
+YS+ ++ E+RE AA+EIRRAI GRIPD LRNCVNK
Sbjct: 517 WYSEQASLEMREAAATEIRRAITGRIPDSLRNCVNK 552
>UniRef50_Q20595 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 727
Score = 370 bits (911), Expect = e-101
Identities = 173/294 (58%), Positives = 227/294 (77%), Gaps = 2/294 (0%)
Query: 8 PKRARMD--SMRGPIANGPLQSRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTSEIHE 65
P++A D SM NGP SRPLVALLDGRDC+VEMPILKDVATVAFCDAQST EIHE
Sbjct: 156 PQQALNDILSMTSTRMNGPSSSRPLVALLDGRDCSVEMPILKDVATVAFCDAQSTQEIHE 215
Query: 66 KVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYG 125
KVLNEAV ALM+H+I L KEDLEKFK L+++ RIG G+DNIDVKAA ELGIAVC+ PG
Sbjct: 216 KVLNEAVAALMYHSIKLEKEDLEKFKVLKVVFRIGYGIDNIDVKAATELGIAVCHAPGDY 275
Query: 126 VEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGR 185
VE+VAD+T+ LIL+L+RRTYW A E +K G +QVRE + G ++RG LGI+G GR
Sbjct: 276 VEDVADSTLSLILDLFRRTYWHAKSYSETRKTIGADQVRENAVGSKKVRGSVLGILGCGR 335
Query: 186 IGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNH 245
+G+AV LRA+AFG ++IFYDP++ +G +K+LG RVYT+ + + +SDC+SLHC+L +
Sbjct: 336 VGTAVGLRARAFGLHIIFYDPFVREGHDKALGFERVYTMDEFMSRSDCISLHCNLGDETR 395
Query: 246 HLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFN 299
+IN +++Q + G ++VNT+ GL+++ LAAALK G ++ AALDVH++ F+
Sbjct: 396 GIINADSLRQCKSGVYIVNTSHAGLINENDLAAALKNGHVKGAALDVHDSVRFD 449
>UniRef50_Q13ZE9 Cluster: Putative dehydrogenase,
D-3-phosphoglycerate dehydrogenase-like; n=1;
Burkholderia xenovorans LB400|Rep: Putative
dehydrogenase, D-3-phosphoglycerate dehydrogenase-like -
Burkholderia xenovorans (strain LB400)
Length = 354
Score = 179 bits (436), Expect = 1e-43
Identities = 120/344 (34%), Positives = 171/344 (49%), Gaps = 26/344 (7%)
Query: 37 RDCTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRII 96
RD VE + ++ D + I ++ L+WH + +T+E + + R+I
Sbjct: 25 RDLDVERGVTGELIDYQVYDEIDAAAIPDEEWTSCDAILVWHRMKITREVVSRLSRCRMI 84
Query: 97 VRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKK 156
VR+G G DN+D A E GI V NVP YG EVAD + ++L L R L K
Sbjct: 85 VRVGVGFDNVDTAACSERGIPVSNVPNYGTTEVADHAIAMMLYLARG---LGTYQARIKA 141
Query: 157 FTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSL 216
V E R+RG T G +G+GRIG+A+A RA A +VI++DP+LP+G E L
Sbjct: 142 DPAHGFVAENVPVVRRLRGGTFGAIGMGRIGTAIARRAAAHDMHVIYHDPFLPEGHELGL 201
Query: 217 GLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGL 276
G RV +L +LL ++D VSLH L++ ++++ + M+P + +N ARG LVD + +
Sbjct: 202 GYERVGSLDELLARADVVSLHVPLSDATRFMMSDAQFQAMKPNSIFINIARGKLVDVDAV 261
Query: 277 AAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPN 336
L G I AA LDV NEP L R G A
Sbjct: 262 YRTLLSGHIAAAGLDVLPNEPPMPLPPLLEAWR------------------NGEEWLAGR 303
Query: 337 LLCTPHAAFYSDASAQELREMAASEIRRAIV-GRIPDCLRNCVN 379
+ TPHAAFYS+A ++R +A + +V GR LRN VN
Sbjct: 304 FIVTPHAAFYSEAGYLDMRTFSAQMLVDYLVHGR----LRNNVN 343
>UniRef50_Q8TYK0 Cluster: Predicted dehydrogenase related to
phosphoglycerate dehydrogenase; n=9; Archaea|Rep:
Predicted dehydrogenase related to phosphoglycerate
dehydrogenase - Methanopyrus kandleri
Length = 522
Score = 177 bits (432), Expect = 4e-43
Identities = 109/252 (43%), Positives = 144/252 (57%), Gaps = 8/252 (3%)
Query: 46 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDN 105
L+++ V + EI E V + + T + T+E +E+ K L++I R G GVDN
Sbjct: 18 LEELGEVVVLEDADEEEIREHVRDADAWVVRSGTRV-TRELIEEAKNLKVIARAGVGVDN 76
Query: 106 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 165
IDVKAA E GI V N P VA+ TM LIL L R+ VR G E R+
Sbjct: 77 IDVKAATERGIIVVNAPESSSISVAEHTMGLILALARKIPQADRSVRRG------EWDRK 130
Query: 166 ASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQ 225
G + G TLG++GLGRIG VA RAKAF V YDPY+P+ + + LG+ V L+
Sbjct: 131 RFMG-VELAGKTLGLIGLGRIGQQVAKRAKAFEMEVTAYDPYIPEKVAEELGVELVDELE 189
Query: 226 DLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRI 285
+LL ++D VS+H L E +I E +K+M+ AFLVN ARG +VD+E L ALK+G I
Sbjct: 190 ELLERADVVSIHVPLTEETEGMIGEEELKRMKSSAFLVNCARGKIVDEEALIKALKEGWI 249
Query: 286 RAAALDVHENEP 297
AALDV EP
Sbjct: 250 AGAALDVFAEEP 261
>UniRef50_Q58424 Cluster: D-3-phosphoglycerate dehydrogenase; n=7;
Euryarchaeota|Rep: D-3-phosphoglycerate dehydrogenase -
Methanococcus jannaschii
Length = 524
Score = 175 bits (425), Expect = 3e-42
Identities = 103/253 (40%), Positives = 146/253 (57%), Gaps = 8/253 (3%)
Query: 45 ILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVD 104
IL++V V + E+ EK+ + V + T + T++ +EK + L++I R G GVD
Sbjct: 17 ILEEVGEVEVATGLTKEELLEKIKDADVLVVRSGTKV-TRDVIEKAEKLKVIGRAGVGVD 75
Query: 105 NIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVR 164
NIDV+AA E GI V N P VA+ TM L+L R ++ G E R
Sbjct: 76 NIDVEAATEKGIIVVNAPDASSISVAELTMGLMLAAARNIPQATASLKRG------EWDR 129
Query: 165 EASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTL 224
+ G + G TLG++GLGRIG V RAKAFG N+I YDPY+P + +S+G+ V +
Sbjct: 130 KRFKGI-ELYGKTLGVIGLGRIGQQVVKRAKAFGMNIIGYDPYIPKEVAESMGVELVDDI 188
Query: 225 QDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGR 284
+L ++D ++LH L H+I I M+ A +VN ARGGL+D++ L ALK+G+
Sbjct: 189 NELCKRADFITLHVPLTPKTRHIIGREQIALMKKNAIIVNCARGGLIDEKALYEALKEGK 248
Query: 285 IRAAALDVHENEP 297
IRAAALDV E EP
Sbjct: 249 IRAAALDVFEEEP 261
>UniRef50_A3S1P6 Cluster: Dehydrogenase; n=1; Prochlorococcus
marinus str. MIT 9211|Rep: Dehydrogenase -
Prochlorococcus marinus str. MIT 9211
Length = 317
Score = 172 bits (419), Expect = 2e-41
Identities = 108/308 (35%), Positives = 162/308 (52%), Gaps = 28/308 (9%)
Query: 65 EKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGY 124
+++ ++ AL+WH +I ++ L K+ ++R IVR G G DNID++ + I V N P Y
Sbjct: 28 DQLTSQTTIALVWHEVI-NQDFLSKYPSIRAIVRYGVGFDNIDLEICRKRKIIVVNTPDY 86
Query: 125 GVEEVADTTMCLILNLYRRTYWLANMVREGK-KFTGPEQVREASAGCARIRGDTLGIVGL 183
G++EV+DT + +IL L R+ +E + ++G ++ RIR +LGI+GL
Sbjct: 87 GIDEVSDTALAMILCLTRKINSFQEFAKEDEYSWSG----KDIPFPVKRIRDMSLGIIGL 142
Query: 184 GRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEH 243
GRIG +A + A NV F+DPYLP G+EK LGL R +LQDLL SD VS+H LN
Sbjct: 143 GRIGGCLARKFTALSNNVGFHDPYLPSGVEKVLGLKRFQSLQDLLRNSDIVSIHTPLNHE 202
Query: 244 NHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLA-AALKQGRIRAAALDVHENE-PFNVF 301
+ L+NE I M+ G++L+N +RG +V D+ + AL ++ DV E P +
Sbjct: 203 SKGLVNEDFISNMKDGSYLINVSRGAIVKDKSIIYDALVSHKLEGYGTDVWTQEPPTDKD 262
Query: 302 QAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASE 361
Q Y+N + A ++ PH A+YS S +E R A
Sbjct: 263 QLYINWKKENAY--------------------AGRIIINPHTAYYSHESLEEARTKACKN 302
Query: 362 IRRAIVGR 369
I GR
Sbjct: 303 CLNIIKGR 310
>UniRef50_A6FZB7 Cluster: Putative dehydrogenase; n=1; Plesiocystis
pacifica SIR-1|Rep: Putative dehydrogenase -
Plesiocystis pacifica SIR-1
Length = 337
Score = 169 bits (410), Expect = 2e-40
Identities = 103/276 (37%), Positives = 150/276 (54%), Gaps = 13/276 (4%)
Query: 28 RPLVALLD---GRD---CTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTII 81
RP+VA+LD G+ VE +L + A++++ + L +A ++W
Sbjct: 3 RPVVAILDFEPGKHFAVADVEAAVLGSEVELRLLRARASAAVLP-ALADADAIIVWSRFE 61
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
L + L + R IV G +++D++AA GI VCNVP YG EEVAD L+L L
Sbjct: 62 LDADALATLERCRGIVCASVGYEHVDLEAARARGIPVCNVPDYGTEEVADHATALLLGLA 121
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R+ L VREG + + R+RG +LG+VG GRIG+A RA+AFG
Sbjct: 122 RKLAVLDRSVREG------QWDWQLGGMPTRLRGQSLGVVGFGRIGAAFTRRAQAFGLEP 175
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
F+DP++P G+EK LG+ R +L +LL + +S+H S N N LI + ++ GA
Sbjct: 176 AFFDPHVPSGVEKVLGVRRCESLDELLEGAQVLSIHASANPANRGLIGAEALAKLPRGAL 235
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L+NTARG LVD + + AL G++ A LDV EP
Sbjct: 236 LINTARGSLVDTQAVVDALASGQLGGAGLDVLAEEP 271
>UniRef50_A4EQ78 Cluster: Dehydrogenase; n=1; Roseobacter sp.
SK209-2-6|Rep: Dehydrogenase - Roseobacter sp. SK209-2-6
Length = 343
Score = 165 bits (402), Expect = 2e-39
Identities = 124/352 (35%), Positives = 173/352 (49%), Gaps = 33/352 (9%)
Query: 24 PLQSRPLVAL--LDGRDCTVEMPILKDV-ATVAFCDAQSTSEIHEKVLNEAVGALMWHTI 80
P RPLV + D D +VE IL+ A V A+ +++ + A A+M
Sbjct: 9 PRSDRPLVVITDFDFGDVSVETEILEAAGAEVVALQAKKETDLFDAARRCA--AMMNQYA 66
Query: 81 ILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNL 140
+ E + + + +I R G GVD +DV AA GI V NV Y EEVAD + L L L
Sbjct: 67 RIGHETITRMQRCEVIARYGVGVDIVDVNAATAKGILVTNVQNYCTEEVADHAIALWLAL 126
Query: 141 YRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
R+ L + R G Q + R+RG T+G+V LG+IG A+A RA+AFG N
Sbjct: 127 ARK---LPDYDRA--THAGLWQWQSGQP-VHRLRGRTMGVVSLGKIGQAIAARARAFGVN 180
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
VI YDP+LP LG+ V +LL +SD + + + HH +++ M+PGA
Sbjct: 181 VIAYDPFLPGEAAAKLGVELV-GKPELLARSDYILMQAPMTPDTHHFLSDAEFAAMKPGA 239
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXX 320
LVNT RG VD++ L AL +G + AA LD E EP A P
Sbjct: 240 ILVNTGRGPTVDNKALFRALTEGHLAAAGLDDPEEEP-----AKRANWTP---------- 284
Query: 321 XCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPD 372
L PN+L TPHAA+YS+ S R AA+++ + + G+ PD
Sbjct: 285 ------DDNLLFTLPNVLVTPHAAYYSEESILAARVTAATQVAKVLTGQNPD 330
>UniRef50_A2U4T1 Cluster: D-3-phosphoglycerate dehydrogenase; n=14;
Bacillales|Rep: D-3-phosphoglycerate dehydrogenase -
Bacillus coagulans 36D1
Length = 541
Score = 160 bits (389), Expect = 7e-38
Identities = 92/225 (40%), Positives = 131/225 (58%), Gaps = 8/225 (3%)
Query: 73 GALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADT 132
G ++ + +TK+ +E LR+I R G GVDNIDV AA GI V N PG +
Sbjct: 46 GLIVRNQTKVTKDIIEASGNLRVIARAGVGVDNIDVDAATRKGIIVVNSPGGNTISATEH 105
Query: 133 TMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVAL 192
T+ ++L+L R N+ + K + RE G + TLGI+G G+IG+ VA
Sbjct: 106 TLAMMLSLSR------NIPQAHKSAAAGKWEREKFKGVELFK-KTLGIIGTGKIGTEVAK 158
Query: 193 RAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFT 252
RAKAFG V+ YDPYL + LG+ + TL ++ Q+D ++LH L + HLINE
Sbjct: 159 RAKAFGMAVLGYDPYLTEERAAKLGIKKA-TLDEIAAQADFITLHTPLMKETKHLINEAF 217
Query: 253 IKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ + + G ++N ARGGLVD++ L AL++GR+ AALDV ENEP
Sbjct: 218 LAKTKKGVRIINCARGGLVDEQALLQALQEGRVAGAALDVFENEP 262
>UniRef50_A7HM61 Cluster: Glyoxylate reductase; n=1;
Fervidobacterium nodosum Rt17-B1|Rep: Glyoxylate
reductase - Fervidobacterium nodosum Rt17-B1
Length = 317
Score = 159 bits (387), Expect = 1e-37
Identities = 95/217 (43%), Positives = 127/217 (58%), Gaps = 6/217 (2%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+ KE + K +II G +NID++AA E GI V N PG E AD LIL +
Sbjct: 55 IDKEFIYSLKKAKIIANYAVGYNNIDIEAAKERGIYVTNTPGVLTEATADIAFALILAVA 114
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
RR VREGK F G + + G + G TLG++G+GRIG AVA RA FG N+
Sbjct: 115 RRIVESDKFVREGK-FVGWKP--KLFLGYD-LYGKTLGVIGMGRIGQAVARRALGFGMNI 170
Query: 202 IFYDPY-LPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
++Y+ LP+ IEK V + +L+ SD +SLH L + +HLIN+ I +M+P A
Sbjct: 171 VYYNRNRLPEEIEKQYNAKYV-NIDELVEISDYISLHTPLTKETYHLINKERIAKMKPNA 229
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
LVNTARG +VD++ L ALK+ RI A DV+ENEP
Sbjct: 230 ILVNTARGPVVDEQALYEALKERRIAGAGFDVYENEP 266
>UniRef50_Q8EMM3 Cluster: Dehydrogenase; n=2; cellular
organisms|Rep: Dehydrogenase - Oceanobacillus iheyensis
Length = 329
Score = 157 bits (382), Expect = 5e-37
Identities = 88/226 (38%), Positives = 136/226 (60%), Gaps = 9/226 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T+ +E L+++VR G GVDN+D+ AA E G+ VCNVP YG+ EVAD + ++LN
Sbjct: 58 VTRSVIENLPDLKLVVRYGVGVDNVDIAAATEHGVQVCNVPDYGMNEVADQALAMMLNFT 117
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R + + VR+G + S R T+G++G+GRIGS+ A + K+ G V
Sbjct: 118 RSISRMNSFVRKG------VWDYQKSMPLYRHSEQTVGVIGVGRIGSSFAKKVKSLGCRV 171
Query: 202 IFYDP-YLPDGIEKSLG-LTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPG 259
+ YDP YL + +KS + L +LL Q+D VS+HC L++ +LI+E +++M+P
Sbjct: 172 VAYDPKYLDEKAKKSPDFIDEFLPLNELLEQADVVSIHCPLDK-ARNLIDEKELQKMKPT 230
Query: 260 AFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYL 305
A+L+N +RGG+++++ L AL I AA+DV ENEP A L
Sbjct: 231 AYLINVSRGGIINEQALNKALTNQWIAGAAVDVAENEPLQPESALL 276
Score = 35.1 bits (77), Expect = 4.2
Identities = 16/44 (36%), Positives = 24/44 (54%)
Query: 325 LLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVG 368
L + L + N +CTPH +YS+ +A EL+ A E R + G
Sbjct: 269 LQPESALLEHDNFICTPHMGWYSEQAALELKRKVAEESIRHLNG 312
>UniRef50_Q67TJ9 Cluster: Phosphoglycerate dehydrogenase; n=1;
Symbiobacterium thermophilum|Rep: Phosphoglycerate
dehydrogenase - Symbiobacterium thermophilum
Length = 540
Score = 155 bits (377), Expect = 2e-36
Identities = 91/217 (41%), Positives = 128/217 (58%), Gaps = 8/217 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T E L + L+++ R G GVDNIDV AA E G+ V NVPG A+ L++ +
Sbjct: 51 VTAEVLARGTRLKVVGRAGVGVDNIDVAAATERGVVVVNVPGANTYSTAEHAFGLLIAVA 110
Query: 142 RRTYWLAN-MVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
R + + REG+ R + G + G TLGI+GLGRIGS VA+RA+AFG
Sbjct: 111 RNIPQAHHALAREGR------WDRMSFVG-TELHGKTLGIIGLGRIGSEVAVRARAFGMR 163
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
V+ YDPY+P + LG+T V +L+ LL + D +++H + + LI + M+P A
Sbjct: 164 VLAYDPYVPHSRAEHLGVTLVPSLRGLLPEVDFLTIHAAKTPESARLIGAAELALMKPTA 223
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+VN ARGG+VD+E L ALK+GR+ AALDV EP
Sbjct: 224 RIVNCARGGMVDEEALYRALKEGRLAGAALDVFAAEP 260
>UniRef50_Q89EL0 Cluster: Blr7063 protein; n=1; Bradyrhizobium
japonicum|Rep: Blr7063 protein - Bradyrhizobium
japonicum
Length = 387
Score = 155 bits (375), Expect = 3e-36
Identities = 87/218 (39%), Positives = 123/218 (56%), Gaps = 5/218 (2%)
Query: 80 IILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILN 139
I +TK ++ ++ ++I GVD++DVKAA GI V N+P +EEVAD M L+L
Sbjct: 100 IPITKSIIDALESCKVITLGSVGVDSVDVKAATARGIPVTNIPDTFIEEVADHAMMLLLA 159
Query: 140 LYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGF 199
+RR MVR G+ G R A R+ G TLG + GR+ AVA RA FG
Sbjct: 160 GFRRLVEQDRMVRSGRWAEG----RPALLKIPRLMGQTLGFISFGRVARAVAKRAAPFGL 215
Query: 200 NVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPG 259
++ YDP++ + + G+ TL ++L QSD VS+H HH++ E +QM+ G
Sbjct: 216 RMMAYDPFIQETLMYDHGVIPA-TLNEVLSQSDFVSMHAPARPEVHHMLTEKHFRQMKKG 274
Query: 260 AFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ +NT RG VD+E L AL++G I AALDV E EP
Sbjct: 275 SIFINTGRGATVDEESLIKALQEGWIAHAALDVLEKEP 312
>UniRef50_A6UQN3 Cluster: D-3-phosphoglycerate dehydrogenase; n=2;
Methanococcus|Rep: D-3-phosphoglycerate dehydrogenase -
Methanococcus vannielii SB
Length = 523
Score = 154 bits (374), Expect = 4e-36
Identities = 88/253 (34%), Positives = 139/253 (54%), Gaps = 9/253 (3%)
Query: 45 ILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVD 104
ILK+ V S EI +K+ +A ++ +TKE ++ + L++I R G GVD
Sbjct: 17 ILKEAGEVEIATGISIEEIKQKI-KDADALVVRSGTTVTKEIIDASENLKVIARAGVGVD 75
Query: 105 NIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVR 164
N+D+ AA E G+ V N P VA+ L+L+ R +++G E R
Sbjct: 76 NVDLDAATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQATASLKKG------EWDR 129
Query: 165 EASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTL 224
++ G + TLGIVGLGRIG VA RA+AF N++ YDPY+P+ + LG+ ++ ++
Sbjct: 130 KSFKGM-EVYAKTLGIVGLGRIGQQVAKRAQAFEMNIVAYDPYIPENVASELGI-KLLSV 187
Query: 225 QDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGR 284
+L +S+ ++LH L H+I + M+ ++N ARGGL+D+ L A+ G+
Sbjct: 188 DELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENALYDAINCGK 247
Query: 285 IRAAALDVHENEP 297
++AA LDV E EP
Sbjct: 248 VKAAGLDVFEEEP 260
>UniRef50_Q7UQL2 Cluster: Phosphoglycerate dehydrogenase; n=2;
Planctomycetaceae|Rep: Phosphoglycerate dehydrogenase -
Rhodopirellula baltica
Length = 540
Score = 153 bits (372), Expect = 8e-36
Identities = 87/230 (37%), Positives = 126/230 (54%), Gaps = 7/230 (3%)
Query: 68 LNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVE 127
LNE A++ + +T E LE LR +VR G G DNID AA GI V N P
Sbjct: 41 LNEFDAAILRSGVTITPESLEGNTRLRALVRAGVGTDNIDKPAATRRGIVVMNTPAGNTV 100
Query: 128 EVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIG 187
A+ T ++L + R N+ + R+ G ++ G TLGIVG+GRIG
Sbjct: 101 STAEHTFAMLLAMSR------NIAAANQSLVEGRWDRKKFMG-TQVAGKTLGIVGMGRIG 153
Query: 188 SAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHL 247
VA RA+AF +V+ +DP+L D +SL + RV T+ D+L Q D +++H L L
Sbjct: 154 REVASRAQAFDMDVVAFDPFLTDDQAESLKVRRVATVDDMLPQIDYLTVHTPLTPETRGL 213
Query: 248 INEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
I +++++PG ++N ARGG+ D E + LK G++ ALDV+ENEP
Sbjct: 214 IGMEQLEKVKPGLRIINVARGGIYDSEAMVEGLKSGKLGGVALDVYENEP 263
>UniRef50_Q9WYG2 Cluster: Phosphoglycerate dehydrogenase, putative;
n=2; Thermotoga|Rep: Phosphoglycerate dehydrogenase,
putative - Thermotoga maritima
Length = 327
Score = 153 bits (370), Expect = 1e-35
Identities = 100/235 (42%), Positives = 130/235 (55%), Gaps = 10/235 (4%)
Query: 63 IHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVP 122
I +L E V AL+ T +T E +E +L+II + G GVDNID++AA + GI V
Sbjct: 35 IDPDILKE-VDALIVGTHPVTAEMVEN-SSLKIIAKHGVGVDNIDLEAATKKGIPVTITA 92
Query: 123 GYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVG 182
G VA+ T+ I L R W N K F E+ E + G + G TLG+VG
Sbjct: 93 GANSLSVAELTIAFIFALSRGLVWAHN-----KLFL--ERRWEGTVG-QEVSGKTLGVVG 144
Query: 183 LGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNE 242
G IG V +A G NV+ YDPY+ + L T V L+ LL +SD VSLH LNE
Sbjct: 145 FGSIGREVVKKAVCLGMNVLVYDPYVSKDSVRLLEATPVDDLEQLLKESDFVSLHVPLNE 204
Query: 243 HNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++I E + M+ AFL+NT+RG LVD+E L ALK+GRI AALDV EP
Sbjct: 205 STKNMIGERELSLMKKSAFLINTSRGELVDEEALVKALKEGRIAGAALDVFSEEP 259
>UniRef50_Q483F8 Cluster: Putative glyoxylate reductase; n=1;
Colwellia psychrerythraea 34H|Rep: Putative glyoxylate
reductase - Colwellia psychrerythraea (strain 34H / ATCC
BAA-681) (Vibriopsychroerythus)
Length = 311
Score = 152 bits (368), Expect = 2e-35
Identities = 90/210 (42%), Positives = 116/210 (55%), Gaps = 11/210 (5%)
Query: 91 KALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANM 150
+++++I IG G DNID+ AA GIAV N P E+ AD LIL R+
Sbjct: 59 ESIKLIANIGVGYDNIDLAAATAKGIAVTNTPVV-TEDTADLAFSLILAASRQLTANEKF 117
Query: 151 VREGK-KFTGPEQVREASAGCA--RIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY 207
+R G+ T P GC + G LGI+G G IG AVA RAKAF + ++ P
Sbjct: 118 LRNGQWSATNP-------IGCLGKTVHGAKLGIIGFGEIGQAVARRAKAFNMEIFYHGPR 170
Query: 208 LPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTAR 267
E SL L D+L SD +S++C LNE+ HHLIN TI MRP A LVNT R
Sbjct: 171 RKIDAEVSLEAVYFENLTDMLAASDIISINCPLNENTHHLINADTIATMRPDAILVNTGR 230
Query: 268 GGLVDDEGLAAALKQGRIRAAALDVHENEP 297
G L+D+ L A+K+G + AA LDV E+EP
Sbjct: 231 GPLIDESALVGAMKKGHLFAAGLDVFEHEP 260
>UniRef50_Q1CG62 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=8; Yersinia|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase family
protein - Yersinia pestis (biovar Antiqua strain
Nepal516)
Length = 316
Score = 151 bits (367), Expect = 3e-35
Identities = 98/279 (35%), Positives = 145/279 (51%), Gaps = 33/279 (11%)
Query: 95 IIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREG 154
+IVR G GVDNID+ AA + G+ +CNVP YG+EEVAD + L L R+ +R G
Sbjct: 68 VIVRYGVGVDNIDLSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRYEAGIRSG 127
Query: 155 KKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEK 214
+ ++ + G +R T+G++GLGRI A A R FG +I +DPY+ + +
Sbjct: 128 R-----WEIDQMVDGVRSLRDTTVGLIGLGRIARAYATRMAVFGCRIIGFDPYVTETEAR 182
Query: 215 SLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDE 274
S G+ + ++ + +SLH L LI+ I +M GA L+N ARGGLV++
Sbjct: 183 SAGIEPL-PQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARGGLVNEV 241
Query: 275 GLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDA 334
L AL +G + A LDV E EP A L++ P
Sbjct: 242 ALIEALTRGHLSGAGLDVFEQEPLPADSA----------------------LRKAP---- 275
Query: 335 PNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDC 373
+LL +PHAAF+SDAS ++L+++A+ E R + G C
Sbjct: 276 -HLLLSPHAAFFSDASVKKLQQLASEEALRGLRGEPLRC 313
>UniRef50_Q8R716 Cluster: Phosphoglycerate dehydrogenase and related
dehydrogenases; n=5; Clostridia|Rep: Phosphoglycerate
dehydrogenase and related dehydrogenases -
Thermoanaerobacter tengcongensis
Length = 533
Score = 151 bits (365), Expect = 5e-35
Identities = 90/218 (41%), Positives = 127/218 (58%), Gaps = 9/218 (4%)
Query: 84 KEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRR 143
+E +EK + L++I R G+GVDNIDV+AA + GI V N P A+ T+ L+L + R
Sbjct: 54 RELIEKGEKLKVIGRAGNGVDNIDVEAATQRGILVVNTPAGNTIAAAELTIGLMLAIARN 113
Query: 144 TYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIF 203
+ G + R+ G + G T+GI+GLGRIGS VA R AF VI
Sbjct: 114 IPQAYHAALNG------DFRRDRFKG-VELNGKTVGIIGLGRIGSLVASRLAAFNMRVIA 166
Query: 204 YDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLV 263
YDPY+PD + G+ RV TL +LL QSD +++H E +I E K+M+ G +V
Sbjct: 167 YDPYMPDERFEKCGVKRV-TLDELLEQSDFITIHIPKTEETKKMIGEKEFKKMKKGVRIV 225
Query: 264 NTARGGLVDDEGLAAALKQGRIRAAALDVHENEP-FNV 300
N ARGG++D++ L A+K+G + A LDV E EP +NV
Sbjct: 226 NAARGGIIDEKALYNAIKEGIVAAVGLDVLEVEPKYNV 263
>UniRef50_O67741 Cluster: D-3-phosphoglycerate dehydrogenase; n=2;
Aquifex aeolicus|Rep: D-3-phosphoglycerate dehydrogenase
- Aquifex aeolicus
Length = 533
Score = 150 bits (364), Expect = 7e-35
Identities = 82/220 (37%), Positives = 127/220 (57%), Gaps = 15/220 (6%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+TKE LE+ + L+++ R G GVDN+D++ A + GI V N PG + TM +L +
Sbjct: 55 VTKELLERAEKLKVVGRAGVGVDNVDIEEATKRGILVVNTPGANTIGATELTMMHMLTIM 114
Query: 142 RRTYW----LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAF 197
R + + N + KKF G E + G LGI+GLG IGS VA+RAKAF
Sbjct: 115 RNGHKAHESMLNYKWDRKKFMGEE-----------LYGRILGIIGLGNIGSQVAIRAKAF 163
Query: 198 GFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMR 257
G V+ YDPY+P + LG+ V L D+L + D +++H L ++I+E + M+
Sbjct: 164 GMKVMAYDPYIPREKAEKLGVKLVDNLHDMLREIDVLTIHAPLTHETKNMIDEKEFEIMK 223
Query: 258 PGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
G ++VN ARGG+++++ L ++ G+I+ ALDV+ EP
Sbjct: 224 DGVYIVNCARGGIINEKALIKYMESGKIKGVALDVYSKEP 263
>UniRef50_O66939 Cluster: D-lactate dehydrogenase; n=1; Aquifex
aeolicus|Rep: D-lactate dehydrogenase - Aquifex aeolicus
Length = 334
Score = 149 bits (360), Expect = 2e-34
Identities = 107/334 (32%), Positives = 164/334 (49%), Gaps = 24/334 (7%)
Query: 46 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDN 105
LKD++ + S++ E L +A ++ LT+E L K L++I G D+
Sbjct: 20 LKDLSLKIY--TTDVSKVPENELKKAELISVFVYDKLTEELLSKMPRLKLIHTRSVGFDH 77
Query: 106 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 165
ID+ + GI V ++P Y E VA+ T +IL L +R + + V KK +
Sbjct: 78 IDLDYCKKKGILVTHIPAYSPESVAEHTFAMILTLVKRLKRIEDRV---KKLNFSQDSEI 134
Query: 166 ASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYT-L 224
+ R+ TLG++G GRIGS VA+ AFG V+ YD + + K G VYT L
Sbjct: 135 LARELNRL---TLGVIGTGRIGSRVAMYGLAFGMKVLCYDVVKREDL-KEKGC--VYTSL 188
Query: 225 QDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGR 284
+LL +SD +SLH + HH+INE I M+ G +L+NTARG +VD + L A ++G+
Sbjct: 189 DELLKESDVISLHVPYTKETHHMINEERISLMKDGVYLINTARGKVVDTDALYRAYQRGK 248
Query: 285 IRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCTPHAA 344
LDV E+E + + Y G + C KD N++ TPH A
Sbjct: 249 FSGLGLDVFEDEEILILKKYTEG-KATDKNLKILELAC---------KD--NVIITPHIA 296
Query: 345 FYSDASAQELREMAASEIRRAIVGRIPDCLRNCV 378
+Y+D S + +RE ++ + G + N V
Sbjct: 297 YYTDKSLERIREETVKVVKAFVKGDLEQIKGNFV 330
>UniRef50_Q1PZY1 Cluster: Similar to D-3-phosphoglycerate
dehydrogenase; n=1; Candidatus Kuenenia
stuttgartiensis|Rep: Similar to D-3-phosphoglycerate
dehydrogenase - Candidatus Kuenenia stuttgartiensis
Length = 535
Score = 149 bits (360), Expect = 2e-34
Identities = 90/237 (37%), Positives = 127/237 (53%), Gaps = 15/237 (6%)
Query: 65 EKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGY 124
+ V+ G ++ LT LEK + L+ I R G GVDNIDV AA + GI V N P
Sbjct: 45 DAVIKMCDGVIVRSNTKLTAPVLEKSEKLKAICRAGVGVDNIDVPAATKKGIVVMNTPAG 104
Query: 125 GVEEVADTTMCLILNLYRRTYWLANMVREGK----KFTGPEQVREASAGCARIRGDTLGI 180
+ A+ T+ L+ +L R V+EGK KFTG + + G T GI
Sbjct: 105 NIISTAEHTIALLCSLSRFVPQACASVKEGKWEKKKFTGQQ-----------LTGKTFGI 153
Query: 181 VGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSL 240
+GLGR+G VA RA A VI YDP++ I + V L+DLL Q+D +++H +L
Sbjct: 154 IGLGRVGRQVAKRAAALEMKVIGYDPFITTEISSQYNIHIVKNLRDLLAQADYITIHVTL 213
Query: 241 NEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
N+ +LI M+ G ++N ARGG++ +E L A+K G++ AALDV E EP
Sbjct: 214 NKETKNLITSKEFSLMKKGVQIINCARGGVICEEDLYNAIKTGQVAGAALDVFEEEP 270
>UniRef50_A6W4F1 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase NAD-binding; n=2; Actinomycetales|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase
NAD-binding - Kineococcus radiotolerans SRS30216
Length = 326
Score = 148 bits (359), Expect = 3e-34
Identities = 102/285 (35%), Positives = 134/285 (47%), Gaps = 35/285 (12%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
L+ +R + R G GVD +DV A G+AVCNVP YG E V+D + L L RR W
Sbjct: 60 LDALPTVRAVGRYGVGVDTVDVDACTARGVAVCNVPDYGTESVSDHAIALALAAARRIAW 119
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
+ VR G P +R + G G+VGLG IG+A A +A G+ V+ D
Sbjct: 120 MDRRVRAGAGELAP--LRPVH----QFGGRVFGVVGLGLIGAATARKAAGLGYRVVATDA 173
Query: 207 YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
G ++ V TL DLL ++ VSLH L E HLI + +MRP A +VNT+
Sbjct: 174 RRAPGT--TVDGVEVVTLDDLLARAHVVSLHVPLTEGTRHLIGAAELARMRPDAVVVNTS 231
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLL 326
RGG++D LA AL+ GR+ A LDV E EP GH
Sbjct: 232 RGGVLDTAALADALRAGRLHGAGLDVFEEEPLP------PGH------------------ 267
Query: 327 QQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIP 371
PL + TPH A+YS+ S EL+ + GR P
Sbjct: 268 ---PLATLDTAVLTPHLAWYSEESYGELKRRTVQNVVDVCAGRPP 309
>UniRef50_Q81T55 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=41; cellular
organisms|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase family protein - Bacillus anthracis
Length = 323
Score = 147 bits (357), Expect = 5e-34
Identities = 96/267 (35%), Positives = 141/267 (52%), Gaps = 8/267 (2%)
Query: 33 LLDGRDCTVEMPILKDVATVAFCDAQ--STSEIHEKVLNEAVGALMWHTIILTKEDLEKF 90
L+ G+ + + +LKD + + S E+ E+V ++ + T + TKE ++
Sbjct: 5 LVAGKIPEIGLELLKDHDVEMYDKEELISLDELTERVKDKDALLSLLSTKV-TKEVIDAA 63
Query: 91 KALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANM 150
+L+I+ G+G DNID AGE GIAV N P E A+ T L+L RR +
Sbjct: 64 PSLKIVANYGAGYDNIDYTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTL 123
Query: 151 VREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPD 210
R TG + G T+GI+GLG IG AVA RAKAFG N+++ P
Sbjct: 124 CRT----TGFNGWAPLFFLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKP 179
Query: 211 GIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGL 270
E L T V TL++LL +D ++++C+ N HH+I+E K M+ A++VN +RG +
Sbjct: 180 EAESELEATYV-TLEELLQTADFITINCAYNPKLHHMIDEEQFKMMKKTAYIVNASRGPI 238
Query: 271 VDDEGLAAALKQGRIRAAALDVHENEP 297
+ + LA ALK I AALDV E EP
Sbjct: 239 MHEAALAHALKTNEIEGAALDVFEFEP 265
>UniRef50_A6C853 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Planctomyces maris DSM 8797|Rep: D-3-phosphoglycerate
dehydrogenase - Planctomyces maris DSM 8797
Length = 328
Score = 147 bits (356), Expect = 7e-34
Identities = 86/220 (39%), Positives = 124/220 (56%), Gaps = 10/220 (4%)
Query: 81 ILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNL 140
I ++E L++ L++I R G G D +D+ AA I V PG VA+ L++ +
Sbjct: 59 IYSREVLQQLPDLKVISRYGVGFDAVDLAAADAQNIVVTITPGVNHHSVAEQAFALLMGI 118
Query: 141 YRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
R T VR G E RE + R+ G T+GIVGLGRIG AVA RA G +
Sbjct: 119 ARMTRTQDRAVRSG------EWERELTP---RVWGSTIGIVGLGRIGQAVATRAIGMGMH 169
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
V+ YDP+ + K+ + ++ +L++LL QSD V+LH + +IN T+ M+PG+
Sbjct: 170 VLAYDPFPNEEFAKTHQI-KLLSLEELLKQSDYVTLHLPVTPETIDIINRDTLALMKPGS 228
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNV 300
L+NTARGGL+D+ L AL+ G +R A LDV + EP V
Sbjct: 229 VLINTARGGLIDENALVEALESGHLRGAGLDVFKKEPLPV 268
>UniRef50_A5MYX9 Cluster: Putative uncharacterized protein; n=1;
Clostridium kluyveri DSM 555|Rep: Putative
uncharacterized protein - Clostridium kluyveri DSM 555
Length = 329
Score = 147 bits (356), Expect = 7e-34
Identities = 86/215 (40%), Positives = 123/215 (57%), Gaps = 6/215 (2%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+TKE +E L+II G +N+D+ AA E + V N+PG+ EEVA T+ +I++L
Sbjct: 61 MTKEIIESLPNLKIITLQSIGYNNVDISAATENNVCVTNIPGFCTEEVALHTIGMIIDLV 120
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R+ +L +VR+GK P R+ T+G+ G I A+ KA G NV
Sbjct: 121 RKITFLDRLVRKGK--WDPL----CGYKTYRLTDKTIGLYFFGSIPKAMMPMLKAMGLNV 174
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ Y P + G +V T +LL +SD VSLHC L HLI+E +K M+ A+
Sbjct: 175 LVYAPTKTKEYLEEFGAEKVETFDELLIKSDFVSLHCPLMASTTHLISERELKLMKESAY 234
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
L+NTARG +VD+ L ALK+GRI+AAA+DV E+E
Sbjct: 235 LINTARGKVVDETALIKALKEGRIKAAAVDVIEDE 269
>UniRef50_Q8EN61 Cluster: Phosphoglycerate dehydrogenase; n=2;
Bacillaceae|Rep: Phosphoglycerate dehydrogenase -
Oceanobacillus iheyensis
Length = 528
Score = 147 bits (355), Expect = 9e-34
Identities = 85/217 (39%), Positives = 128/217 (58%), Gaps = 8/217 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T+ +EK L+II R G GVDNID++AA E G+ V N P A+ TM +I+ L
Sbjct: 56 VTRALIEKASNLKIIGRAGVGVDNIDLEAATENGVIVVNAPNGNTNSAAEHTMAMIMALS 115
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R + +++ K++ R+ G ++ TLGIVGLGRIG+ VA RAK NV
Sbjct: 116 RNIPQAYHALKQ-KQWD-----RKRFVG-VELKQKTLGIVGLGRIGAEVAARAKGQRMNV 168
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
I YDP+ + + +G+ + TL+D+L D +++H L + HLIN+ M+ G
Sbjct: 169 IAYDPFFTEEKAEQMGV-QYGTLEDVLRAGDFITVHTPLLKETKHLINKDAFDLMKDGVQ 227
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPF 298
+VN ARGG++D++ L A++ G++ AALDV E EPF
Sbjct: 228 IVNCARGGIIDEDALYDAIQSGKVAGAALDVFEQEPF 264
>UniRef50_A1SPF8 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding precursor; n=2;
Actinomycetales|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding precursor - Nocardioides sp.
(strain BAA-499 / JS614)
Length = 318
Score = 147 bits (355), Expect = 9e-34
Identities = 90/220 (40%), Positives = 120/220 (54%), Gaps = 8/220 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T+E L ++ +VR G G DN+DV AA ELGI V NVP YGVE VAD +L L
Sbjct: 57 MTREVLAGMRSGGTVVRYGIGYDNVDVPAARELGIHVANVPDYGVETVADHASASLLALA 116
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCAR-IRGDTLGIVGLGRIGSAVALRAKAFGFN 200
RR + +R + VR G R +R +G+VG+GRI AV R + FGF+
Sbjct: 117 RRLPIYSGRIRTER------WVRPGDIGAIRGMRSSVVGLVGMGRIAQAVHDRLRPFGFS 170
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
+ YDP + +T V +L +L Q+ +SLH N +I E + ++PG
Sbjct: 171 FVAYDPLCDPEVFVERDVTPV-SLLELAQQAHAISLHAPSNAETRGMIGEEFFRAVQPGT 229
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNV 300
LVNTARG LVD+ L AL +GRI A ALDV + EP V
Sbjct: 230 VLVNTARGSLVDEAALVRALDEGRIAAVALDVTDPEPVPV 269
Score = 40.3 bits (90), Expect = 0.11
Identities = 18/41 (43%), Positives = 26/41 (63%)
Query: 328 QGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVG 368
+ PL++ +L TPHAAFY + S L+ +AA E RA+ G
Sbjct: 270 ESPLRNRDEVLLTPHAAFYDEDSLDRLQLLAAEEAGRALRG 310
>UniRef50_Q82U25 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase; n=3; Nitrosomonadaceae|Rep: D-isomer
specific 2-hydroxyacid dehydrogenase - Nitrosomonas
europaea
Length = 311
Score = 146 bits (354), Expect = 1e-33
Identities = 93/221 (42%), Positives = 127/221 (57%), Gaps = 19/221 (8%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
LT+ L ALR+I R G+G+DN+D++AA L I V N P + VA+ T+ L+L+
Sbjct: 61 LTEHVLTSASALRVIARCGTGMDNVDLEAARRLNIQVSNTPEAPAQAVAELTLGLMLDCL 120
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R+ + VR+G+ P A AR T+GIVGLG IG VA +AFG V
Sbjct: 121 RQINRIDRSVRQGE---WPRSQGRLLA--AR----TVGIVGLGHIGRRVAKLCQAFGAQV 171
Query: 202 IFYDPYL---PDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRP 258
I +DP+L PDG+E + L LL Q+D V+LH + H+LI+ I +M+P
Sbjct: 172 IAHDPHLQLAPDGVE-------LVALTTLLEQADLVTLHLPYSPAVHYLIDAEAIDRMKP 224
Query: 259 GAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFN 299
G L+N ARGGLVD+ L AAL G + AAALD E EP++
Sbjct: 225 GTILINAARGGLVDETALCAALNTGHLEAAALDSFEQEPYH 265
>UniRef50_A6CKS4 Cluster: Putative uncharacterized protein; n=1;
Bacillus sp. SG-1|Rep: Putative uncharacterized protein
- Bacillus sp. SG-1
Length = 322
Score = 146 bits (353), Expect = 2e-33
Identities = 88/228 (38%), Positives = 128/228 (56%), Gaps = 10/228 (4%)
Query: 72 VGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVAD 131
V A++ T L++ +EK L++I R G GVDNID++AA + GI V N P V VA+
Sbjct: 44 VDAILIRTAKLSRVVIEKASKLKVIARHGIGVDNIDLEAASDRGILVTNAPFANVNAVAE 103
Query: 132 TTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA 191
+ LIL+ R+ + + +R G +VR G ++G TLG+VG G IG VA
Sbjct: 104 HVLTLILSGSRQLIQVDSALRNGDF-----EVRNRKFGI-ELKGKTLGVVGFGNIGQLVA 157
Query: 192 LRAK-AFGFNVIFYDPYL-PDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLIN 249
+ G +V+ YDPY+ + + + L + +L ++L SD V++H HHLIN
Sbjct: 158 EKCHYGLGMDVLVYDPYVREENVSSYVQLNQ--SLSEVLASSDIVTIHVPYLPSTHHLIN 215
Query: 250 EFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
E ++QM+ A LVN ARGG++D+ L AL G IR A LD E EP
Sbjct: 216 EEALQQMKKDAILVNAARGGIIDEIALEKALGSGEIRGACLDCFETEP 263
>UniRef50_A1HMI9 Cluster: Phosphoglycerate dehydrogenase; n=1;
Thermosinus carboxydivorans Nor1|Rep: Phosphoglycerate
dehydrogenase - Thermosinus carboxydivorans Nor1
Length = 326
Score = 146 bits (353), Expect = 2e-33
Identities = 87/217 (40%), Positives = 126/217 (58%), Gaps = 7/217 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T+E ++K L++I + G GVDNID+ AA LGI V N PG VA+ T+ +I+NLY
Sbjct: 56 ITQELIQKAPKLKMIQKTGVGVDNIDLAAAKTLGIPVANTPGGNATSVAELTLGMIINLY 115
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R+ + + RE KK G E ++G T GI+G G IG VA ++AFG NV
Sbjct: 116 RK---INILDRETKK--GNWMSWEFRPSSYEVKGKTHGIIGFGNIGREVARLSQAFGTNV 170
Query: 202 IFYD-PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
I+YD L EK L +T + L +LL +SD +S+H L +LI+E + ++P A
Sbjct: 171 IYYDLRRLEPAEEKRLNVT-YHELNELLQKSDIISIHLPLTPDTKNLISERELALLKPTA 229
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L+N ARG +VD+ L ALK+ ++ A +DV EP
Sbjct: 230 LLINVARGNIVDEVALYRALKENKLLGAGIDVWSKEP 266
>UniRef50_Q9X1C1 Cluster: D-3-phosphoglycerate dehydrogenase; n=3;
Thermotogaceae|Rep: D-3-phosphoglycerate dehydrogenase -
Thermotoga maritima
Length = 306
Score = 145 bits (352), Expect = 2e-33
Identities = 90/216 (41%), Positives = 119/216 (55%), Gaps = 11/216 (5%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T + +E K L+II R G G+DNIDV+ A E GI V N PG VA+ M L+L
Sbjct: 56 VTADIIEAGKNLKIIARAGIGLDNIDVQKAKEKGIKVLNTPGASAPSVAELAMGLMLACA 115
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R ++EGK ++A G + G TLG++G G IG VA RA AFG +
Sbjct: 116 RHIARATVSLKEGK------WEKKALKG-KELLGKTLGLIGFGNIGQEVAKRALAFGMKI 168
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
I YDP P E L + V L L +SD +SLH L E H+IN +I +M+ G
Sbjct: 169 IAYDPAKP---ETDLPVEYV-DLDTLFKESDFISLHVPLTESTRHIINRESIAKMKDGVI 224
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+VNTARGG +D+E L + G++ AA LDV E EP
Sbjct: 225 IVNTARGGTIDEEALYEEVVSGKVYAAGLDVFEVEP 260
>UniRef50_Q5KYJ7 Cluster: Dehydrogenase; n=3; Firmicutes|Rep:
Dehydrogenase - Geobacillus kaustophilus
Length = 334
Score = 145 bits (352), Expect = 2e-33
Identities = 83/217 (38%), Positives = 127/217 (58%), Gaps = 9/217 (4%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
++ E + + + +II R G GV+ +DV AA E GI V NV Y ++EV+D + L+L+L
Sbjct: 58 ISAEVIAQLEKCKIISRYGVGVNTVDVDAATEKGIIVANVTDYSIDEVSDHALALLLSLA 117
Query: 142 RRTYWLANMVREGK-KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
R+ L + V+ G F + + R+RG TLG+VGLGRI A+A +A+AFG
Sbjct: 118 RKIVKLNHEVKSGTWNFNVGKPIY-------RLRGRTLGLVGLGRIPQALAKKAQAFGLR 170
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
VI YDPY+P + L + ++ L D+ QSD +S+H L + +I++ +
Sbjct: 171 VIAYDPYVPAKVADELNV-QLLGLNDVFRQSDYISVHAPLTKETKGMISDEQFNLAKKEL 229
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+VNTARG ++D+ L AL++G+I A LDV E EP
Sbjct: 230 IIVNTARGPVIDESALIRALQEGKISGAGLDVTECEP 266
Score = 39.5 bits (88), Expect = 0.19
Identities = 18/55 (32%), Positives = 27/55 (49%)
Query: 322 CSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRN 376
C + PL N++ TPH A+YS+ S +EL+ A + + G P L N
Sbjct: 264 CEPIQPDNPLLKMENVVITPHVAWYSEESEKELKRKTAQNVADVLSGYYPTYLVN 318
>UniRef50_P73990 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family; n=2; Cyanobacteria|Rep: D-isomer
specific 2-hydroxyacid dehydrogenase family -
Synechocystis sp. (strain PCC 6803)
Length = 318
Score = 145 bits (352), Expect = 2e-33
Identities = 83/206 (40%), Positives = 121/206 (58%), Gaps = 11/206 (5%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L+ + + G GVD ID+ AA +LGI N P +EVAD + ++ L R + + VR
Sbjct: 74 LKALAKWGIGVDAIDLAAAKQLGILTSNTPNVFGDEVADVAIGYLILLARELHCIDQAVR 133
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY-LPDG 211
+G+ ++R S +RG T GI+G+G IG A+A+R ++ G ++ YDP+ +
Sbjct: 134 QGEWL----KIRGHS-----LRGKTAGIIGVGSIGQAIAVRLQSMGLKLLGYDPHPISAD 184
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
+ GL V LQD+L Q+DC+ L C+L N HL+N T QM+PG +L+N ARGGLV
Sbjct: 185 FCEQTGLHPV-PLQDVLQQADCLFLACNLTPDNFHLLNADTFDQMKPGVWLINVARGGLV 243
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
D L L+ G++ AALDV E EP
Sbjct: 244 DQAALIETLQTGKVAKAALDVFEQEP 269
>UniRef50_A7CYD6 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Opitutaceae bacterium TAV2|Rep: D-3-phosphoglycerate
dehydrogenase - Opitutaceae bacterium TAV2
Length = 529
Score = 145 bits (352), Expect = 2e-33
Identities = 83/216 (38%), Positives = 124/216 (57%), Gaps = 8/216 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T+E + L+++ R G GVDN+DV+AA E G+ V N P A+ T IL
Sbjct: 54 ITREVIAAAPQLKVVGRAGVGVDNVDVEAATERGVVVMNTPAGNTIATAELTFTHILCGS 113
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R A +REGK R++ +G + TLG++G+GRIG VA RA AFG V
Sbjct: 114 RPVSQAAASMREGK------WDRKSFSGVELFK-KTLGVIGMGRIGGEVARRAVAFGMKV 166
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ YDPYL K++ + V TL ++L Q+D +++H L + ++I+E + + + G
Sbjct: 167 LAYDPYLAPSRAKAMQV-EVATLDEILAQADYITVHMPLTDDTKYMIDEAALAKCKKGVR 225
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L N ARGG++ + L AALK G + AA LDV+E+EP
Sbjct: 226 LFNCARGGIIKESALIAALKSGHVAAAGLDVYEDEP 261
>UniRef50_Q18XF4 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=2; Desulfitobacterium
hafniense|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding - Desulfitobacterium
hafniense (strain DCB-2)
Length = 320
Score = 145 bits (351), Expect = 3e-33
Identities = 83/213 (38%), Positives = 122/213 (57%), Gaps = 10/213 (4%)
Query: 85 EDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRT 144
EDLE L++I++ G+GVD+ID+KAA GI V N PG VAD +L+L R+
Sbjct: 65 EDLEAAPNLKLIIKHGTGVDSIDLKAAAARGITVANAPGTNANSVADLAFGFMLSLARQI 124
Query: 145 YWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFY 204
R+G F G ++ + G TLG++GLG+IG V RA F N++ Y
Sbjct: 125 VSADKRTRDG--FWGTVMGKD-------VYGKTLGVLGLGQIGKGVIRRASGFDMNILGY 175
Query: 205 DPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVN 264
D EK + R TL++++ ++D +S+H L E ++I+ +++MRP AFL+N
Sbjct: 176 DLVHHSQFEKEYRV-RAATLEEIMSEADYISVHLPLLESTKNIIDRSLLEKMRPTAFLIN 234
Query: 265 TARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
T+RGG+VD+ L LK+ RI AALDV EP
Sbjct: 235 TSRGGVVDETALYDLLKEKRIAGAALDVFATEP 267
>UniRef50_A7HDB1 Cluster: D-3-phosphoglycerate dehydrogenase; n=5;
Proteobacteria|Rep: D-3-phosphoglycerate dehydrogenase -
Anaeromyxobacter sp. Fw109-5
Length = 528
Score = 144 bits (350), Expect = 3e-33
Identities = 85/233 (36%), Positives = 125/233 (53%), Gaps = 8/233 (3%)
Query: 65 EKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGY 124
E+++ + G + +T + L+K L++I R G GVDN+D+ AA G+ V N PG
Sbjct: 38 ERIVGDYDGLAVRSATKVTAQLLDKAARLKVIGRAGVGVDNVDLAAATRRGVVVMNTPGG 97
Query: 125 GVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLG 184
VA+ + +IL L R V+ GK Q E + G TLG+VG+G
Sbjct: 98 SSITVAELALSMILALSRHVAAATGSVKAGKWEKKRFQGHE-------LAGRTLGVVGIG 150
Query: 185 RIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHN 244
IGS + RA A G V+ +DP++ LG + V L L ++D VS+H L +
Sbjct: 151 NIGSVLVARAVALGMRVVAFDPFISAEAAAKLGASLV-DLDTLWREADVVSIHVPLTDKT 209
Query: 245 HHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
HL++ + +M+ GA LVN ARGG+VD+ LA AL+ G++ A LDV E EP
Sbjct: 210 RHLVDATALGKMKKGALLVNCARGGIVDERALADALRSGQLGGAGLDVFEQEP 262
>UniRef50_Q8YEC6 Cluster: Gluconate 2-dehydrogenase; n=72;
Alphaproteobacteria|Rep: Gluconate 2-dehydrogenase -
Brucella melitensis
Length = 360
Score = 144 bits (349), Expect = 5e-33
Identities = 83/206 (40%), Positives = 122/206 (59%), Gaps = 3/206 (1%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L++I G+GVDNIDV AA GI V N P E+ AD T+ L+L++ RR AN++
Sbjct: 99 LKLIANFGNGVDNIDVAAAARRGITVTNTPNVLTEDTADMTLALLLSVPRRLVEGANVIN 158
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYD-PYLPDG 211
E + P G RI G LGIVG+GRIG+AVA RAKAFG ++ +++ +
Sbjct: 159 E-RHGQWPGWSPTWMLG-RRIWGKRLGIVGMGRIGTAVARRAKAFGLSIHYHNRKRVSPQ 216
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
+E+ L T +L +L + D +S++C HL++ I M+P A+LVNTARG ++
Sbjct: 217 VEEELEATYWDSLDQMLARMDIISVNCPSTPATFHLLSARHIALMQPTAYLVNTARGQII 276
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
D+ L +++GR+ A LDV E+EP
Sbjct: 277 DENALIDLIEEGRLAGAGLDVFEHEP 302
>UniRef50_A0ZEB8 Cluster: Predicted dehydrogenase; n=6;
Cyanobacteria|Rep: Predicted dehydrogenase - Nodularia
spumigena CCY 9414
Length = 341
Score = 144 bits (349), Expect = 5e-33
Identities = 90/254 (35%), Positives = 139/254 (54%), Gaps = 8/254 (3%)
Query: 45 ILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVD 104
+L++ + + +EI++ + EA G + + L + + K L++I G G D
Sbjct: 32 LLEEYTNIQILKDPTKNEINQAI-QEASGVFVRYPTKLDAQAIGLAKKLKVISTSGFGTD 90
Query: 105 NIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVR 164
ID+ A + G+ V N PG VA+ T+C+IL L ++ +L V+ G + QV+
Sbjct: 91 AIDISVATKHGVVVVNNPGLSTTAVAEHTICMILALAKKLTFLNQCVKTGN-YLIRNQVQ 149
Query: 165 EASAGCARIRGDTLGIVGLGRIGSAVALRAKA-FGFNVIFYDPYLPDGIEKSLGLTRVYT 223
++ G TLGIVGLGRIGSAVA + A F V+ YDPY+ +++G T V
Sbjct: 150 PM-----QLEGKTLGIVGLGRIGSAVASKCSAAFQMRVLAYDPYVLPSQAEAVGGTLVEN 204
Query: 224 LQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQG 283
L LL +SD VSLH L + + + K+M+P AFL+NT+RG +V ++ L A+ +
Sbjct: 205 LDYLLAESDFVSLHPELTDETYEMFALEAFKKMKPTAFLINTSRGKIVCEQDLVVAIGEK 264
Query: 284 RIRAAALDVHENEP 297
I AA+DV E EP
Sbjct: 265 WISGAAIDVFEPEP 278
>UniRef50_A5URV2 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Roseiflexus sp.
RS-1|Rep: D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Roseiflexus sp. RS-1
Length = 323
Score = 144 bits (348), Expect = 6e-33
Identities = 87/207 (42%), Positives = 111/207 (53%), Gaps = 8/207 (3%)
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
ALR I R G GVDNID+ AA + GI V N P E A+ + L+L L A V
Sbjct: 68 ALRAICRPGIGVDNIDIAAATKRGILVINTPDGPTESTAEHAVALLLAL-------AKQV 120
Query: 152 REGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA-LRAKAFGFNVIFYDPYLPD 210
+ E R A +RG TLGIVGLGRIG VA + + G +V+ YDP +PD
Sbjct: 121 VASDRVLRTEGWRAARLRGIEVRGKTLGIVGLGRIGRRVAQICRQGLGMHVVAYDPPVPD 180
Query: 211 GIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGL 270
+L + R TL DLL + +SLHC+L HLI + + PGA L+N +RG +
Sbjct: 181 ETFATLDVARAATLDDLLPHAQFLSLHCALTPETRHLIGARELGLLPPGALLINVSRGAV 240
Query: 271 VDDEGLAAALKQGRIRAAALDVHENEP 297
VD L AAL GR+ A LDV + EP
Sbjct: 241 VDQAALIAALSDGRLAGAGLDVFDPEP 267
>UniRef50_Q5V1E2 Cluster: D-3-phosphoglycerate dehydrogenase; n=2;
Haloarcula marismortui|Rep: D-3-phosphoglycerate
dehydrogenase - Haloarcula marismortui (Halobacterium
marismortui)
Length = 323
Score = 144 bits (348), Expect = 6e-33
Identities = 86/217 (39%), Positives = 121/217 (55%), Gaps = 9/217 (4%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T E +E +L+++ R G G+DNI V+AA G+ V NVP Y VEEV+ T L+L
Sbjct: 58 VTAEVIEAADSLKVVGRAGIGMDNIAVRAAVAAGVTVVNVPDYSVEEVSTHTFALMLACL 117
Query: 142 RRTYWLANMVREGK-KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
RR V+ G+ K+ + +R R+ G T+G+V G++ S A + + F +
Sbjct: 118 RRIPTFDRSVKRGEWKWAVGQPIR-------RLAGSTVGLVAFGKLASRFAAKLRGFDID 170
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
VI YDPY P+ LG+ V TL+ LL SD VSLH L + +I+ + +M A
Sbjct: 171 VIAYDPYAPEYRMGDLGVESV-TLETLLGDSDIVSLHAPLTDETRGMIDADALDRMHDDA 229
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
LVNTARGGLVD+ L AL G + A LDV + EP
Sbjct: 230 LLVNTARGGLVDETALYDALISGDLGGAGLDVRKPEP 266
Score = 40.7 bits (91), Expect = 0.084
Identities = 16/43 (37%), Positives = 27/43 (62%)
Query: 330 PLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPD 372
PL D +++C+PH A+YS+ S EL + A ++ R + G P+
Sbjct: 271 PLHDLDSVVCSPHVAWYSEESRVELTQTVAEDVIRVLRGEQPE 313
>UniRef50_Q8EMJ8 Cluster: Hypothetical conserved protein; n=1;
Oceanobacillus iheyensis|Rep: Hypothetical conserved
protein - Oceanobacillus iheyensis
Length = 319
Score = 143 bits (347), Expect = 8e-33
Identities = 87/228 (38%), Positives = 126/228 (55%), Gaps = 10/228 (4%)
Query: 72 VGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVAD 131
V A++ T I +++ LE L+II R G GVDNIDVKAA + GI V N P + VA+
Sbjct: 44 VDAIIARTEIYSEKVLENANRLKIIARHGIGVDNIDVKAATKYGIKVTNTPSANINAVAE 103
Query: 132 TTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA 191
+ +L R + VR G +R G + G T+GI+G G IG +A
Sbjct: 104 LVLTFMLASTRHLLPIDEAVRAGNF-----DIRNQLFGY-ELNGKTVGIIGFGNIGRLIA 157
Query: 192 LRAK-AFGFNVIFYDPYLP-DGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLIN 249
+ + G N++ +DPY+ + +E + LT +L+DLL SD V+LH HHLI+
Sbjct: 158 EKCRLGLGMNIVVFDPYVTAESVEPYVELTE--SLEDLLRISDVVTLHVPYVRATHHLIH 215
Query: 250 EFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ + + M+ A L+N ARGG+VD++ L AL G IR A +DV E EP
Sbjct: 216 KDSFQIMKKDAILINAARGGVVDEKALVEALMNGEIRGACVDVFEEEP 263
>UniRef50_Q0EUV6 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=4; Thermoanaerobacter
ethanolicus|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding - Thermoanaerobacter
ethanolicus X514
Length = 320
Score = 143 bits (346), Expect = 1e-32
Identities = 88/218 (40%), Positives = 120/218 (55%), Gaps = 14/218 (6%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T++ + K L++I R G G DN+D+ AA + GI V N P VAD + L+L L
Sbjct: 62 VTEDVINAGKKLKVISRYGVGYDNVDLNAAKKKGIVVTNTPNANNNSVADLVIGLMLVLA 121
Query: 142 RRTYWLANMVREG--KKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGF 199
R + +V+ G K+ G E I G TLGI+GLG+IG VA RAK F
Sbjct: 122 RNLLAVDRIVKSGGWKRIMGTE-----------IYGKTLGIIGLGKIGKGVAKRAKGFDM 170
Query: 200 NVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPG 259
NV+ YD Y + G+T + ++LL QSD V++H L LI E + M+P
Sbjct: 171 NVLCYDVYPDLKFSEEYGVTYC-SFEELLKQSDIVTIHVPLTPETKGLIGERELGMMKPT 229
Query: 260 AFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
AFL+NT+RGG+VD+ L AL +I AALDV E EP
Sbjct: 230 AFLINTSRGGIVDERALYNALANKKIAGAALDVMEQEP 267
>UniRef50_Q1AXS3 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Rubrobacter xylanophilus DSM 9941|Rep:
D-3-phosphoglycerate dehydrogenase - Rubrobacter
xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 527
Score = 142 bits (345), Expect = 1e-32
Identities = 89/239 (37%), Positives = 129/239 (53%), Gaps = 8/239 (3%)
Query: 59 STSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAV 118
S E+ E++ E G ++ +T E +E L+ I R G GVDNID++AA + GI V
Sbjct: 30 SPGELLERI-GEYDGLIVRSATKVTAEVIEAAGRLKAIGRAGIGVDNIDIEAATKRGILV 88
Query: 119 CNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTL 178
N P A+ T+ L+L + RR +R G E R A G + TL
Sbjct: 89 ANAPESNTVAAAEHTLGLMLAVARRIPAADASLRRG------EWNRAAFKG-VEVAEKTL 141
Query: 179 GIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHC 238
G+VGLG +GS VA A G V+ YDPY+ + +S+ + R +L+++ ++D VSLH
Sbjct: 142 GLVGLGHVGSIVARGALGMGMRVLAYDPYVSEERMRSMNVERAGSLEEIFEEADFVSLHV 201
Query: 239 SLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++ E + +M+P A+L+N ARGG+VD+ L ALKQG I AALDV EP
Sbjct: 202 PRTPQTTGMVGEEELARMKPTAYLINVARGGIVDETALYNALKQGEIAGAALDVFAEEP 260
>UniRef50_Q9KP72 Cluster: 2-hydroxyacid dehydrogenase family
protein; n=30; Proteobacteria|Rep: 2-hydroxyacid
dehydrogenase family protein - Vibrio cholerae
Length = 325
Score = 142 bits (344), Expect = 2e-32
Identities = 104/341 (30%), Positives = 164/341 (48%), Gaps = 34/341 (9%)
Query: 24 PLQSRPLVALLDGRDCT--VEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTII 81
P S P V LD + +P L DA ++ E++L A ++ + ++
Sbjct: 4 PTTSLPTVVFLDRATIPRHISLPALPFEHHWLEYDACEPQQVVERLL--AADIVITNKVV 61
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
LT+E L + L++I +G +N+D+ A +L IAVCNV GY V + + ++ L
Sbjct: 62 LTREMLIQLPKLKLIAISATGTNNVDLPACRDLNIAVCNVQGYATRSVPEHVVAMMFALR 121
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R N + G+ + +Q + I G T+GI+G G +G A A A+A G +V
Sbjct: 122 RNLIGYHNDIAAGE-WQRHKQFCFFTHPIGDIAGSTMGIIGSGALGQATANLARALGMHV 180
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ + +E G T + + +L QSD +SLHC L + ++I+E + QM P A
Sbjct: 181 LLAER--KGQVECRDGYT---SFEQVLAQSDVLSLHCPLTDETRNIISEAELAQMNPNAL 235
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXX 321
L+NT RGGLVD++ L ALK+ +I A +DV EP ++ +
Sbjct: 236 LINTGRGGLVDEQALVDALKRRQIAGAGVDVFSAEPADMDNPLIAN-------------- 281
Query: 322 CSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEI 362
+D PNLL TPH A+ SD+S Q+L + I
Sbjct: 282 ----------RDLPNLLLTPHVAWGSDSSIQQLATILIDNI 312
>UniRef50_A5UQ03 Cluster: D-3-phosphoglycerate dehydrogenase; n=5;
Chloroflexi (class)|Rep: D-3-phosphoglycerate
dehydrogenase - Roseiflexus sp. RS-1
Length = 524
Score = 142 bits (344), Expect = 2e-32
Identities = 86/216 (39%), Positives = 122/216 (56%), Gaps = 8/216 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T E L LR++ R G+GVDNID++AA GI V N P VA+ T+ LIL+L
Sbjct: 53 VTAEVLAAGTRLRVVGRAGTGVDNIDLEAATRQGIMVVNAPASNSVAVAELTIALILSLA 112
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R + V GK R G +R TLG+VGLGRIG+ VA RA+ +V
Sbjct: 113 RHIPQAHSSVVAGK------WERNRFMGF-EVRNKTLGLVGLGRIGAEVARRARGLEMHV 165
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ YDP + LG T + L+++L Q+D VSLH L + ++I+ + QM+ GA+
Sbjct: 166 VAYDPVVSTERAAQLGAT-LAPLEEVLAQADIVSLHVPLIDATRNMIDAARLAQMKRGAY 224
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L+N ARGG+VD+ L A++ G + AALD + EP
Sbjct: 225 LINAARGGVVDEAALLEAIESGHLAGAALDTYSTEP 260
>UniRef50_A1G3C5 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Salinispora arenicola
CNS205|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding - Salinispora arenicola
CNS205
Length = 345
Score = 142 bits (344), Expect = 2e-32
Identities = 86/231 (37%), Positives = 127/231 (54%), Gaps = 7/231 (3%)
Query: 68 LNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVE 127
L EA G + + +T + L+ L ++ G GVDNID+ AA G+ V N PG G +
Sbjct: 41 LREAHGLAVRYPAQITADVLDAAPQLLAVLSSGRGVDNIDIPAASRAGVVVANNPGLGGK 100
Query: 128 EVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIG 187
V++ + L++ + R L + R+ TG + R + + G TLGIVG G +G
Sbjct: 101 PVSEHALGLLIMITRD---LTAVARDA--MTGAWEKRLTTRR-VELTGGTLGIVGCGNVG 154
Query: 188 SAVALRAKA-FGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHH 246
+A RA A F V+ YDPY+ +G T+V L LL ++D VS H LN+
Sbjct: 155 GWMARRASAGFQMRVLAYDPYVSAEQMAQVGATKVDNLDKLLAEADFVSCHPELNDETDG 214
Query: 247 LINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ N+ T QM+ GA+ VNT+RG +V + L AL+ GR+ AAALDV++ EP
Sbjct: 215 MFNDDTFGQMKSGAYFVNTSRGAVVRTDALVRALRSGRLSAAALDVYDQEP 265
>UniRef50_A6CXX0 Cluster: Dehydrogenase; n=1; Vibrio shilonii
AK1|Rep: Dehydrogenase - Vibrio shilonii AK1
Length = 337
Score = 141 bits (342), Expect = 3e-32
Identities = 100/292 (34%), Positives = 143/292 (48%), Gaps = 31/292 (10%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+ + +E+ +II R G GVD +DV+A + GI V NVP Y ++EVAD ++ L L L+
Sbjct: 61 IPRTTIEQLDNCKIICRYGIGVDILDVEACYDHGIKVSNVPDYCIDEVADHSISLGLTLF 120
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCA--RIRGDTLGIVGLGRIGSAVALRAKAFGF 199
RR + KFT Q G R R T G++G GRI +A + A GF
Sbjct: 121 RR-------IPAYNKFTHEGQWHWDIDGLVPKRFRSSTWGLIGFGRIAQNIAKKMTALGF 173
Query: 200 NVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPG 259
VI +DPY+ + G+ +V L L+ SD V++ C LINE ++QM+
Sbjct: 174 KVISFDPYVSGSYMNTFGVEKV-DLDTLISTSDVVNVMCPHTPETDRLINEDRLRQMKSN 232
Query: 260 AFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXX 319
A LVN ARG +VD++ L AL +G I +A LD E EP A L+ P
Sbjct: 233 AVLVNGARGKVVDNKALYKALVEGWIASAGLDDPEEEP-----AKLDNWNP--------- 278
Query: 320 XXCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIP 371
P+ N + TPH A+ S + QE R +AA + ++G P
Sbjct: 279 -------NDNPIFGLDNCIVTPHVAYVSQEAFQECRRIAAENAKAVLLGGEP 323
>UniRef50_A1RDF9 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=1; Arthrobacter
aurescens TC1|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase family protein - Arthrobacter aurescens
(strain TC1)
Length = 329
Score = 141 bits (342), Expect = 3e-32
Identities = 101/304 (33%), Positives = 143/304 (47%), Gaps = 26/304 (8%)
Query: 68 LNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVE 127
++E + ++ T+E +E L+II R G G DN+D+ AA E + V + PG
Sbjct: 38 ISENIDGVILRAETFTREMIEASPRLKIIARHGVGTDNVDIPAASEHSVWVTSTPGSNSN 97
Query: 128 EVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIG 187
VA+ L+L+L RR AN V G G R G + G TLGIVG G IG
Sbjct: 98 AVAEHVFSLLLSLTRRIIPAANRVLAGTWAEG----RGDLVGF-ELSGRTLGIVGFGAIG 152
Query: 188 SAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHL 247
VA A FG V+ DP ++ G V L L +D ++LH L H+
Sbjct: 153 KRVATIANGFGMRVLASDPIATAADAEAAGAVLV-ELDTLYDGADIITLHAPLLSGTRHM 211
Query: 248 INEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNG 307
I+ + M+P A ++NT+RGGL+D++ L AL G + AALDV E E ++ +
Sbjct: 212 ISPRELAMMKPSAIIINTSRGGLIDEDALVTALTNGTLAGAALDVLEAESIDMKDPLTHN 271
Query: 308 HRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIV 367
SV PL + PNLL TPH A + + QE + SE+R +
Sbjct: 272 ---------------SV-----PLHEVPNLLVTPHIAGQTQEAFQEAGTRSWSEVRAVLA 311
Query: 368 GRIP 371
G P
Sbjct: 312 GTTP 315
>UniRef50_Q6A5K9 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, putative D-3- phosphoglycerate
dehydrogenase; n=1; Propionibacterium acnes|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase, putative
D-3- phosphoglycerate dehydrogenase - Propionibacterium
acnes
Length = 321
Score = 141 bits (341), Expect = 4e-32
Identities = 88/221 (39%), Positives = 119/221 (53%), Gaps = 9/221 (4%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
L E + + K L++I + +G +NID+ AA + G+ V + PG E AD L+L +
Sbjct: 54 LDAEMIGQGKNLKVIGQCAAGFNNIDLDAAKQAGVVVTSTPGVLHEATADLAFTLLLEVT 113
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
RRT VR G+ + + AG ++G TLGIVGLG+IG A+A R AFG NV
Sbjct: 114 RRTGEAERWVRAGRAWRY-DHTFMLGAG---LQGATLGIVGLGQIGEAMARRGAAFGMNV 169
Query: 202 IFY-----DPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQM 256
I+ D D + + TR L +L SD VSLHC L + HL++ + M
Sbjct: 170 IYNARHEKDVAAIDAVNLNTQPTRRVELDELFATSDVVSLHCPLTDETRHLVDADALAAM 229
Query: 257 RPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ A+LVNTARG VD+ L ALK G I A LDV E EP
Sbjct: 230 KKTAYLVNTARGACVDEAALVEALKTGAIAGAGLDVFEEEP 270
>UniRef50_Q2AHU0 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Halothermothrix orenii H 168|Rep: D-3-phosphoglycerate
dehydrogenase - Halothermothrix orenii H 168
Length = 527
Score = 141 bits (341), Expect = 4e-32
Identities = 92/258 (35%), Positives = 140/258 (54%), Gaps = 19/258 (7%)
Query: 45 ILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVD 104
IL+ A V F S E + ++ E G ++ + KE L+K + L++I R G+G D
Sbjct: 17 ILEQEADVTFNPDLSREEFLD-IIGEYDGLIVRSMTEVDKEALDKARNLKVIGRAGTGYD 75
Query: 105 NIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREG----KKFTGP 160
NID++ A + GI V N P + T+ ++L L R + EG KK+ G
Sbjct: 76 NIDIEEASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQANQALHEGIWDRKKYMGV 135
Query: 161 EQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGL-T 219
E ++G TLGI+GLGRIGS VA+RA+AFG VI DPYLP EK+ +
Sbjct: 136 E-----------VKGKTLGIIGLGRIGSRVAVRAQAFGMKVIANDPYLPP--EKAAKINV 182
Query: 220 RVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAA 279
+ +++L +SD ++LH L + +H+++ M+ ++N ARG VD + LA A
Sbjct: 183 PLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQALAKA 242
Query: 280 LKQGRIRAAALDVHENEP 297
L + ++ AA+DVHE EP
Sbjct: 243 LAEHKVAGAAIDVHEVEP 260
>UniRef50_A1AQ02 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=3; Bacteria|Rep: D-isomer
specific 2-hydroxyacid dehydrogenase, NAD-binding -
Pelobacter propionicus (strain DSM 2379)
Length = 318
Score = 141 bits (341), Expect = 4e-32
Identities = 86/261 (32%), Positives = 133/261 (50%), Gaps = 9/261 (3%)
Query: 38 DCTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKA-LRII 96
D ++ L D+ D S EI +V + + ++ + L +E + F A +++I
Sbjct: 15 DGKLDFSPLSDLTAFTRYDNSSDEEIPSRVEGQTI--VITKELPLGRELIHCFPASVKLI 72
Query: 97 VRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKK 156
G+G +NID+ AA GI VCNVP Y + VA + +LNL M+R G
Sbjct: 73 CEAGTGYNNIDIAAARSRGIGVCNVPSYSTDAVAQLAITFMLNLSASLVQQQTMLRRGNL 132
Query: 157 FTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSL 216
+ ++ + G TLG++G G IG V A+ G +I + ++ L
Sbjct: 133 DNFQKSLQLPHF---ELNGKTLGVIGFGEIGRRVIAIARTLGMKIIVHSRTPRPELDPDL 189
Query: 217 GLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGL 276
R +L++LL SD VSLHC LN+ H+IN ++ M+P AF++NT+RG L+ + L
Sbjct: 190 ---RFVSLEELLATSDFVSLHCPLNDATRHVINAERLEMMKPTAFIINTSRGPLIHEPAL 246
Query: 277 AAALKQGRIRAAALDVHENEP 297
+ AL +G I A LDV E EP
Sbjct: 247 SQALTRGTIAGAGLDVQEQEP 267
>UniRef50_Q5FKH9 Cluster: Glyoxylate reductase; n=1; Lactobacillus
acidophilus|Rep: Glyoxylate reductase - Lactobacillus
acidophilus
Length = 321
Score = 140 bits (340), Expect = 6e-32
Identities = 83/220 (37%), Positives = 121/220 (55%), Gaps = 6/220 (2%)
Query: 80 IILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILN 139
+I KE ++ K L++I G G D+ID+ A E GI V N P + A+ + +I+
Sbjct: 57 MIFDKEIIDAAKNLKVISTYGVGFDHIDIDYAREKGIVVTNCPNSVLRPTAELALTMIMA 116
Query: 140 LYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGF 199
RR + + +REG V E + I G TLGI+G+GRIG VA AKA G
Sbjct: 117 SARRIRYYDHALREGVFLN----VDEYDSQGYTIEGKTLGILGMGRIGQQVARFAKALGM 172
Query: 200 NVIFYDPY-LPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRP 258
+I+++ + L +E L R L+ SD +SLH + +H+I++ M+
Sbjct: 173 KIIYHNRHQLKPELEAELN-ARYVDFASLVKNSDFLSLHAPATDETYHIIDKDVFNNMKD 231
Query: 259 GAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPF 298
+FL+N ARG LVD + L AALK+G+I AALDV ENEP+
Sbjct: 232 TSFLINVARGSLVDSDDLVAALKEGKIAGAALDVFENEPY 271
>UniRef50_Q1GAM7 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase; n=1; Lactobacillus delbrueckii subsp.
bulgaricus ATCC 11842|Rep: D-isomer specific
2-hydroxyacid dehydrogenase - Lactobacillus delbrueckii
subsp. bulgaricus (strain ATCC 11842 / DSM20081)
Length = 322
Score = 140 bits (340), Expect = 6e-32
Identities = 94/260 (36%), Positives = 143/260 (55%), Gaps = 8/260 (3%)
Query: 42 EMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGS 101
++P L+ V V F A + + + L + AL+ + + +E L+ K L+I+ G
Sbjct: 21 QLPELEKVCEVTFAPAGAGKDWYLANLGD-FDALITGKLPVDQELLDAGKKLKIVSATGV 79
Query: 102 GVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPE 161
G D+IDV A GI V N P ++ A+ L+L L R+ L N + F
Sbjct: 80 GYDHIDVDYASSQGIIVSNCPASVMQPTAEMAFTLLLALSRKLA-LYNQEMRQENFLDTG 138
Query: 162 QVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY-LPDGIEKSLGLTR 220
+ + G + + G TLGI G+GRIG +A A+ FG N+++++ + LP+ E++LG++
Sbjct: 139 LLE--NQGQSPV-GKTLGIFGMGRIGKTLASYARTFGMNILYHNRHQLPEDEERALGVSY 195
Query: 221 VYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAAL 280
V L DLL Q+D VSL+ +H+I+E + M+P AFL+NT+RG VD+ L AL
Sbjct: 196 V-PLADLLSQADYVSLNAPATAETYHVIDEAALSMMQPTAFLINTSRGSQVDEAALLRAL 254
Query: 281 KQGRIRAAALDVHENEP-FN 299
K RI A LDV E EP FN
Sbjct: 255 KGKRIAGAGLDVFEEEPDFN 274
>UniRef50_UPI00015BAF48 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Ignicoccus hospitalis
KIN4/I|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding - Ignicoccus hospitalis
KIN4/I
Length = 308
Score = 140 bits (339), Expect = 8e-32
Identities = 85/214 (39%), Positives = 118/214 (55%), Gaps = 9/214 (4%)
Query: 84 KEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRR 143
+E +E L++I R GSG+DNID++AA E GI V N P VA+ + +++ L RR
Sbjct: 57 REVIEAADKLKVIARAGSGLDNIDLEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARR 116
Query: 144 TYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIF 203
++ + EG+ E G + G TLG+VG GRIG VA +AKA G NVI
Sbjct: 117 AHYSYRKLLEGEW--------EKVMGF-ELAGKTLGVVGFGRIGREVAKKAKALGMNVIA 167
Query: 204 YDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLV 263
YD K +G+ L++LL +SD VSLH L E ++IN IK M+ GA L+
Sbjct: 168 YDVVDLSETAKEMGVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILI 227
Query: 264 NTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
N ARG + D L AL+ G++ LDV+ EP
Sbjct: 228 NAARGEVADYSALLEALESGKLWGVGLDVYPEEP 261
>UniRef50_O29445 Cluster: D-3-phosphoglycerate dehydrogenase; n=2;
cellular organisms|Rep: D-3-phosphoglycerate
dehydrogenase - Archaeoglobus fulgidus
Length = 527
Score = 140 bits (339), Expect = 8e-32
Identities = 81/213 (38%), Positives = 119/213 (55%), Gaps = 8/213 (3%)
Query: 85 EDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRT 144
E ++ K L+II R G GVDNID+ AA + GI V N PG A+ + L+L R+
Sbjct: 56 EVIQAAKNLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKI 115
Query: 145 YWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFY 204
V+EGK R+ G +RG T G++GLGR+G VA R KA NV+ Y
Sbjct: 116 PQADRSVKEGK------WERKKFMGI-ELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAY 168
Query: 205 DPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVN 264
DP++ + +G+ ++ LL SD +++H + LI + ++M+ G +VN
Sbjct: 169 DPFVSKERAEQIGV-KLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVN 227
Query: 265 TARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
ARGG+VD+ L A+K G++ AAALDV+E EP
Sbjct: 228 AARGGIVDEAALYEAIKAGKVAAAALDVYEKEP 260
>UniRef50_Q897N8 Cluster: D-3-phosphoglycerate dehydrogenase; n=4;
Clostridiales|Rep: D-3-phosphoglycerate dehydrogenase -
Clostridium tetani
Length = 533
Score = 140 bits (338), Expect = 1e-31
Identities = 78/207 (37%), Positives = 116/207 (56%), Gaps = 7/207 (3%)
Query: 91 KALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANM 150
K L+++ R G+GVDNID+ A + GI V N P + T+ L+L R
Sbjct: 66 KKLKVVGRAGNGVDNIDIPEATKRGIIVANTPDSNTISACELTIGLLLAQSRNIAKTDRF 125
Query: 151 VREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPD 210
++EG R++ G + TLGI+GLGRIGS VA R AF VI YDPY+ D
Sbjct: 126 LKEGN------WDRDSFMG-TELFNKTLGIIGLGRIGSLVATRMNAFDMKVIAYDPYISD 178
Query: 211 GIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGL 270
K + + TL+DLL +SD +++H E ++I+E ++ M+ G +VN ARG L
Sbjct: 179 ERFKRFNVEKKDTLEDLLKESDFITIHTPRTEETINIISEKELELMKDGVRIVNAARGKL 238
Query: 271 VDDEGLAAALKQGRIRAAALDVHENEP 297
+ ++ L LK+G+I + +DVHE+EP
Sbjct: 239 ISEKALCKGLKKGKIASVGIDVHEHEP 265
>UniRef50_Q0ETU3 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Thermoanaerobacter
ethanolicus X514|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding - Thermoanaerobacter
ethanolicus X514
Length = 324
Score = 140 bits (338), Expect = 1e-31
Identities = 83/217 (38%), Positives = 117/217 (53%), Gaps = 8/217 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T+E +E L+II R G+GVDNIDV AA E GI VCN+P VA+ T+ +ILNL
Sbjct: 53 ITREVIENAPHLKIISRTGAGVDNIDVNAATEKGILVCNLPAVNNLSVAEHTIAMILNLS 112
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRA-KAFGFN 200
++ + VR G + I G LGIVG+G IGS VA + G
Sbjct: 113 KQLSLMDKAVRSGNWGARNSNI------SVEIEGKVLGIVGMGNIGSLVAKKCHDGLGMK 166
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
++ YDPY+ + + V T ++L +SD V+LHC +I I M+ A
Sbjct: 167 IVAYDPYVKEKF-RGYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTA 225
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+L+N ARG ++D++ L ALK+ RI A LDV + EP
Sbjct: 226 YLINAARGTVIDEQALIEALKEKRIAGAGLDVFQQEP 262
>UniRef50_Q1IVI0 Cluster: D-3-phosphoglycerate dehydrogenase; n=2;
Acidobacteria|Rep: D-3-phosphoglycerate dehydrogenase -
Acidobacteria bacterium (strain Ellin345)
Length = 531
Score = 139 bits (337), Expect = 1e-31
Identities = 89/236 (37%), Positives = 126/236 (53%), Gaps = 11/236 (4%)
Query: 65 EKVLNEAVGA---LMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNV 121
E++L + GA ++ + + LE LR+I R G GVDNI+++AA GIAV N
Sbjct: 35 EQLLEQLKGADALIVRSAVFVDAAMLEHADQLRVIGRAGVGVDNIELEAATRKGIAVMNT 94
Query: 122 PGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIV 181
PG VA+ T+ L+L L R + GK + S +RG TLGIV
Sbjct: 95 PGANAIAVAEHTIGLMLALARFIPRATETMHAGKW-------EKKSLQGTELRGKTLGIV 147
Query: 182 GLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLN 241
GLGRIG VA RA +FG ++ +DPY+ I + R+ ++L +D ++LH L
Sbjct: 148 GLGRIGLEVARRAASFGMTLVAHDPYVSPAIAHDAKI-RLADRDEVLAVADYITLHVGLT 206
Query: 242 EHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++IN T+ M+ G +VN ARG L+DD LA A+K G + AALDV EP
Sbjct: 207 PQTANMINATTLATMKKGVRIVNCARGELIDDAALAEAVKSGHVGGAALDVFTEEP 262
>UniRef50_Q11JH0 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Mesorhizobium sp.
BNC1|Rep: D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Mesorhizobium sp. (strain BNC1)
Length = 342
Score = 139 bits (337), Expect = 1e-31
Identities = 89/256 (34%), Positives = 141/256 (55%), Gaps = 11/256 (4%)
Query: 45 ILKDVATVAFCDAQS--TSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSG 102
I+++VA F + S T+E ++ E+ L+ T +T++ L++ LR++ + G G
Sbjct: 25 IIQEVAPPEFDLSFSVDTTEKAHPLIRESDFCLV--TTAITEKLLQESPKLRLVHKWGIG 82
Query: 103 VDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQ 162
+D ID++ A G+ V G VA+ T+ LIL RR +REGK
Sbjct: 83 IDKIDLEGAERQGVYVAITAGSNAGAVAEHTIMLILAALRRLALADQSMREGKWI----- 137
Query: 163 VREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY-LPDGIEKSLGLTRV 221
E C ++ G T+GI+G G IG VA R + F +I++DP+ P +E L T V
Sbjct: 138 YTELRPLCRKLSGKTVGILGFGNIGRNVAQRLQGFDVEIIYHDPFRAPPEVEDRLKATYV 197
Query: 222 YTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALK 281
+ +L+ +S+ ++LHC NHH+IN + +M+ G+ LVN ARG +VD+E + AAL+
Sbjct: 198 -SFDELIKRSNILTLHCPGGAANHHIINASALAKMQRGSVLVNCARGDVVDEEAMVAALQ 256
Query: 282 QGRIRAAALDVHENEP 297
G++ AA LD E EP
Sbjct: 257 SGQLLAAGLDAFEPEP 272
>UniRef50_A4A9T4 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=1; Congregibacter
litoralis KT71|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase family protein - Congregibacter litoralis
KT71
Length = 316
Score = 139 bits (337), Expect = 1e-31
Identities = 90/229 (39%), Positives = 124/229 (54%), Gaps = 11/229 (4%)
Query: 73 GALMW-HTII--LTKEDLEKFK-ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEE 128
GA +W T + +++E + F +L +I +G G DN+D+ AA E GI V N P E+
Sbjct: 42 GATVWLGTAVDPVSRELIASFPDSLGLIANLGVGTDNVDLVAAKERGILVSNTPVV-TED 100
Query: 129 VADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGS 188
AD T L+L RR +R G G A+ R+ G LGI+G G IG
Sbjct: 101 TADLTFALLLATCRRVGECERALRGGDWAGG------AALMGRRVHGAKLGIIGFGAIGQ 154
Query: 189 AVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLI 248
AVA RA+ F +V ++ P E S G +L LL +SD VSL+C L + H++
Sbjct: 155 AVAQRARGFDMDVGYHGPRRKADAEASTGARWYESLDQLLEESDIVSLNCPLTQATRHIM 214
Query: 249 NEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
NE ++ M+P A L+NT RG LVD+ L AAL+ GR+ A LDV E EP
Sbjct: 215 NETSLGLMKPEAILINTGRGPLVDEGALVAALQAGRLAGAGLDVFEFEP 263
>UniRef50_Q6F7L0 Cluster: Glycerate dehydrogenase; n=3;
Gammaproteobacteria|Rep: Glycerate dehydrogenase -
Acinetobacter sp. (strain ADP1)
Length = 318
Score = 139 bits (336), Expect = 2e-31
Identities = 84/218 (38%), Positives = 117/218 (53%), Gaps = 7/218 (3%)
Query: 80 IILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILN 139
+++ E L + L++I+ +G +N+D++AA GI VCN GYG VA T+ L+L
Sbjct: 54 VVINAEALTRLPKLKLILVSATGTNNVDLRAAKAQGIVVCNCQGYGTASVAQHTLTLMLA 113
Query: 140 LYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGF 199
L + V +G+ + Q + G TLGIVG G +G VA A+AFG
Sbjct: 114 LATSLLRYDHAVAQGR-WQQASQFCFLDYPIIELSGKTLGIVGYGELGKEVARLAQAFGM 172
Query: 200 NVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPG 259
++ + LP + L L+ LL Q D +SLHC L EH HLI+ M+P
Sbjct: 173 KILIAN--LPQRPKHEDRLE----LEALLPQVDFLSLHCPLTEHTQHLIDAHAFALMKPS 226
Query: 260 AFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
AFL+N ARGG+V ++ L ALKQGRI AA DV EP
Sbjct: 227 AFLINCARGGIVHEQALLDALKQGRIAGAATDVLSIEP 264
>UniRef50_Q7MT26 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=2;
Porphyromonadaceae|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase family protein - Porphyromonas gingivalis
(Bacteroides gingivalis)
Length = 319
Score = 138 bits (335), Expect = 2e-31
Identities = 89/236 (37%), Positives = 131/236 (55%), Gaps = 8/236 (3%)
Query: 62 EIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNV 121
EI E++++ V ++ I + ++ ++K ++L++I G +NIDV A GI V N
Sbjct: 37 EIAERIVDCDVLCSVFD-IPIGRDLIDKGRSLKLIANYAVGYNNIDVTYAASKGIVVTNT 95
Query: 122 PGYGVEEVADTTMCLILNLYRR-TYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGI 180
P +E AD + L+L+ RR W R+G+ E+ R G + G TLGI
Sbjct: 96 PRAVIEPTADLALALLLSCTRRIAEWDRLFRRDGEMV---ERGRLCRLG-VNLYGKTLGI 151
Query: 181 VGLGRIGSAVALRAKAFGFNVIFYD-PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCS 239
+G G IG+AVA R KAFG NV++ L + EK+ G+T DL+ ++D +SLH
Sbjct: 152 IGFGNIGAAVARRCKAFGMNVLYNKRTRLSEAEEKAQGITFA-DKDDLIRRADVLSLHTP 210
Query: 240 LNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHEN 295
L HLI + M+P A L+NTARG +VD+ L AL++ RI AA LDV EN
Sbjct: 211 LTPETKHLIGTAELSMMKPTAILINTARGAVVDERALVEALREKRIAAAGLDVFEN 266
>UniRef50_O24922 Cluster: Phosphoglycerate dehydrogenase; n=4;
Helicobacter|Rep: Phosphoglycerate dehydrogenase -
Helicobacter pylori (Campylobacter pylori)
Length = 314
Score = 138 bits (335), Expect = 2e-31
Identities = 89/275 (32%), Positives = 143/275 (52%), Gaps = 10/275 (3%)
Query: 33 LLDGRDCTVE-MPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFK 91
+LD + ++ + +LK+VA F + S+I E+ + + L + +++T+E L +
Sbjct: 9 ILDAKSVGLKALEVLKEVADFDFYEVTPPSQIVERSIEAEIMVL--NKVVITQEVLSQLP 66
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
L++I +G DN+D+K+A LGI V NV Y E VA T+ L+L R
Sbjct: 67 KLKLICITATGTDNVDIKSAKALGIEVKNVSAYSTESVAQHTLACALSLLGRINDYDRYC 126
Query: 152 REGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDG 211
+ G+ + I+G G++GLG IG VA A+AFG V++Y P
Sbjct: 127 KSGEYSQSDLFTHISDIKMGLIKGSQWGVIGLGTIGKRVAKLAQAFGAKVVYYSPK---- 182
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
+K R+ +L+DLL SD +S+H LNE LI ++ ++ GA L+N RGG+V
Sbjct: 183 -DKKEEYERL-SLKDLLATSDIISIHAPLNESTRDLIALKELQSLKDGAILINVGRGGIV 240
Query: 272 DDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLN 306
+++ LA L+ + A+ DV EPF A+LN
Sbjct: 241 NEKDLAEILETKDLYYAS-DVFVKEPFEKDHAFLN 274
>UniRef50_A3H6F3 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Caldivirga
maquilingensis IC-167|Rep: D-isomer specific
2-hydroxyacid dehydrogenase, NAD-binding - Caldivirga
maquilingensis IC-167
Length = 326
Score = 138 bits (335), Expect = 2e-31
Identities = 86/205 (41%), Positives = 119/205 (58%), Gaps = 6/205 (2%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
+++I G D+ID+ AA GI V P VE VAD + LI+ L RR +VR
Sbjct: 73 VKVIATYSVGYDHIDLDAATRRGIPVGYTPEVLVEAVADLAIGLIITLARRVIEGDRLVR 132
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
G+ + +V G + G TLGI+GLG IG+AVA RAKAF NVI++ I
Sbjct: 133 SGEAY----KVWGEFLG-TEVWGKTLGILGLGNIGAAVARRAKAFNMNVIYWSRTRKPWI 187
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
E +LGL R L +L QSD + L +L++ +H++NE ++ M+ ++LVN ARG +VD
Sbjct: 188 EVALGL-RYVDLNELFRQSDYLVLTVALSKETYHIVNEERLRLMKNTSYLVNVARGAVVD 246
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
L ALK+G I AALDV+E EP
Sbjct: 247 TNALVKALKEGWIAGAALDVYEEEP 271
>UniRef50_O33116 Cluster: D-3-phosphoglycerate dehydrogenase; n=28;
Actinomycetales|Rep: D-3-phosphoglycerate dehydrogenase
- Mycobacterium leprae
Length = 528
Score = 138 bits (335), Expect = 2e-31
Identities = 87/252 (34%), Positives = 127/252 (50%), Gaps = 9/252 (3%)
Query: 46 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDN 105
L D V + D +++ V EA L+ + E L L+I+ R G G+DN
Sbjct: 20 LGDQVEVRWVDGPDRTKLLAAV-PEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDN 78
Query: 106 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 165
+DV AA G+ V N P + A+ + L+L R+ + E +
Sbjct: 79 VDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQ-------IAEADASLRAHIWKR 131
Query: 166 ASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQ 225
+S I G T+G+VGLGRIG VA R AFG +VI YDPY+ LG+ + +
Sbjct: 132 SSFSGTEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQLGI-ELMSFD 190
Query: 226 DLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRI 285
DLL ++D +S+H LI++ + + +PG +VN ARGGLVD+ LA A++ G +
Sbjct: 191 DLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALADAVRSGHV 250
Query: 286 RAAALDVHENEP 297
RAA LDV EP
Sbjct: 251 RAAGLDVFATEP 262
>UniRef50_Q2S4U0 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD binding domain protein; n=2; cellular
organisms|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD binding domain protein - Salinibacter
ruber (strain DSM 13855)
Length = 321
Score = 138 bits (334), Expect = 3e-31
Identities = 94/257 (36%), Positives = 136/257 (52%), Gaps = 10/257 (3%)
Query: 46 LKDVATVAFCDAQ--STSEIHEKVLNEAVGALMWHTII---LTKEDLEKFKALRIIVRIG 100
++D T+ CD ST + E ++ A GA + +++ +T+ E L+++ +
Sbjct: 18 VRDEHTLTVCDPPDGSTRSVDE-LIALADGADVLLSVLADPITEALFEARPGLQMVSQYA 76
Query: 101 SGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGP 160
GVDNID++AA +AV + PG + AD L+L R VR+G+ F
Sbjct: 77 VGVDNIDLEAAEAHDVAVTHTPGVLTDATADQAWALLLAAARHVPAADRYVRDGR-FERW 135
Query: 161 EQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTR 220
E AR T+GIVG+GRIG+AVA RA FG VI+++ + + R
Sbjct: 136 ETTHLMGMELAR---KTIGIVGMGRIGTAVARRALGFGMEVIYHNRTRANPTVERQVSAR 192
Query: 221 VYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAAL 280
L +LL SD VSLHC N+ +HHL++ +M+ A LVNTARG +VD+ L AL
Sbjct: 193 HVGLGELLTTSDVVSLHCPHNDESHHLLDAAAFSKMKASALLVNTARGPVVDEAALVDAL 252
Query: 281 KQGRIRAAALDVHENEP 297
K G I A LDV E+EP
Sbjct: 253 KSGEIAGAGLDVFEDEP 269
>UniRef50_P35136 Cluster: D-3-phosphoglycerate dehydrogenase; n=8;
Bacillaceae|Rep: D-3-phosphoglycerate dehydrogenase -
Bacillus subtilis
Length = 525
Score = 138 bits (334), Expect = 3e-31
Identities = 84/225 (37%), Positives = 126/225 (56%), Gaps = 9/225 (4%)
Query: 74 ALMWHTIILTKEDL-EKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADT 132
AL+ + EDL K +L+I+ R G GVDNID+ A + G+ V N P A+
Sbjct: 43 ALLVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH 102
Query: 133 TMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVAL 192
T +I +L R AN+ + +++ R A G + + G TLGIVGLGRIGS +A
Sbjct: 103 TFAMISSLMRHIPQ-ANISVKSREWN-----RTAYVG-SELYGKTLGIVGLGRIGSEIAQ 155
Query: 193 RAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFT 252
R AFG V +DP+L + K +G+ T +++L +D +++H L + L+N+ T
Sbjct: 156 RRGAFGMTVHVFDPFLTEERAKKIGVNS-RTFEEVLESADIITVHTPLTKETKGLLNKET 214
Query: 253 IKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
I + + G L+N ARGG++D+ L AL+ G + AALDV E EP
Sbjct: 215 IAKTKKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEP 259
>UniRef50_Q6W1I8 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Rhizobium sp. NGR234|Rep: D-3-phosphoglycerate
dehydrogenase - Rhizobium sp. (strain NGR234)
Length = 327
Score = 138 bits (333), Expect = 4e-31
Identities = 88/230 (38%), Positives = 121/230 (52%), Gaps = 10/230 (4%)
Query: 68 LNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVE 127
L E A + T T+E L + L++I R+G G D+ID AA E G+ + PG E
Sbjct: 46 LLEDCDAAIVSTDPFTREVLAGDRNLKVIARVGVGTDSIDHDAAKEFGVGISVTPGMNAE 105
Query: 128 EVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIG 187
VAD T+ +IL L RR V+ G+ ++V EA+ + T+G++G G IG
Sbjct: 106 TVADQTLAMILGLMRRVVTQDQAVKAGRW----DRVGEATP--TELYRKTVGLIGAGIIG 159
Query: 188 SAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHL 247
AV R FG V+++D +EK G R +L LL SD VSLH L L
Sbjct: 160 KAVIRRLLGFGVRVLYFDAM----VEKVHGAERCGSLDQLLGSSDIVSLHAPLLADTREL 215
Query: 248 INEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+N I M G++L+NT+RGGLV + AAL+ G + AALDV E EP
Sbjct: 216 MNAARIALMPKGSYLINTSRGGLVQQPAVFAALRSGHLAGAALDVFEVEP 265
>UniRef50_A1SM51 Cluster: D-3-phosphoglycerate dehydrogenase; n=15;
Actinobacteria (class)|Rep: D-3-phosphoglycerate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 536
Score = 138 bits (333), Expect = 4e-31
Identities = 86/246 (34%), Positives = 126/246 (51%), Gaps = 9/246 (3%)
Query: 52 VAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAA 111
+ +CD E+ L EA L+ + E L + L++I R G G+DN+DV+AA
Sbjct: 34 IRYCDGADRGELLA-ALPEADAILVRSATKVDAEALAAARRLKVIARAGVGLDNVDVRAA 92
Query: 112 GELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCA 171
+ G+ V N P + A+ + L+L R ++ G E R G
Sbjct: 93 TQAGVMVVNAPTSNIVSAAELAVALMLAAARHISPAHAALKNG------EWKRARYTG-T 145
Query: 172 RIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQS 231
+ T+GIVGLGRIG VA R AFG ++ YDPY+ G +G+ R+ L LL ++
Sbjct: 146 ELYEKTVGIVGLGRIGVLVAQRLSAFGMKIVAYDPYVQAGRAAQMGV-RLVDLDTLLAEA 204
Query: 232 DCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALD 291
D +S+H LI + +++P LVN ARGG+V++ L AALK+GR+ AA LD
Sbjct: 205 DFMSVHLPKTPETVGLIGADQLAKVKPSLVLVNAARGGIVEEAALYAALKEGRVAAAGLD 264
Query: 292 VHENEP 297
V EP
Sbjct: 265 VFAQEP 270
>UniRef50_A4YFM2 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Metallosphaera sedula
DSM 5348|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding - Metallosphaera sedula DSM
5348
Length = 324
Score = 138 bits (333), Expect = 4e-31
Identities = 83/257 (32%), Positives = 137/257 (53%), Gaps = 8/257 (3%)
Query: 46 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDN 105
L +A + + + + + +L +A+ A++ ++ + + + + L++I R G+GVD
Sbjct: 24 LNSLAEIVYFNPYAPEDQIVSLLRDAI-AIVDRKAKISSKIIRELRNLKLIARTGAGVDE 82
Query: 106 --IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQV 163
+D+KAA E I + PG VA+ T+ L + LYR+ LA V+ GK ++
Sbjct: 83 TRVDLKAAKERDIIITYNPGGNSVAVAELTIMLAIALYRKVIPLALSVKAGKW----SEL 138
Query: 164 REASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYT 223
+ + G GI+G G IG VA + V+ YDPY+ I + G+ + +
Sbjct: 139 KPKDTMGHELEGKAWGILGFGNIGKRVAQLVTSLNCKVLGYDPYVSSEIMEKHGVKSL-S 197
Query: 224 LQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQG 283
L++LL +SD +S+H L E HLIN +K M+ A L+N +RGG++DD+ L +L+ G
Sbjct: 198 LEELLSKSDIISIHVPLTESTRHLINSERLKTMKKTAILINVSRGGIIDDKALYESLRNG 257
Query: 284 RIRAAALDVHENEPFNV 300
I AALD E EP V
Sbjct: 258 EIAGAALDTPEEEPVKV 274
>UniRef50_A3EWA5 Cluster: Phosphoglycerate dehydrogenase; n=2;
Bacteria|Rep: Phosphoglycerate dehydrogenase -
Leptospirillum sp. Group II UBA
Length = 535
Score = 137 bits (332), Expect = 5e-31
Identities = 81/220 (36%), Positives = 125/220 (56%), Gaps = 16/220 (7%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T+E L+ L++I R G+G+DN+D++AA E GI V N PG A+ TM L++++
Sbjct: 57 VTREILKNADRLKVIGRAGAGLDNVDLEAATERGIVVMNTPGGNTVTTAEHTMSLLMSMA 116
Query: 142 RRTYWLANMVREGK----KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAF 197
RR + GK KF G E ++ TLGIVG+G+IG VA A+
Sbjct: 117 RRIPQANASNKAGKWEKSKFMGVELFQK-----------TLGIVGMGKIGQHVAQIARGI 165
Query: 198 GFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMR 257
N+I +DPYL + + G+ V +L +L ++D +++H L LIN+ +I +M+
Sbjct: 166 AMNIIAFDPYLTPEVAEKSGVHPV-SLDELFQRADFITVHTPLTPETTGLINKQSIAKMK 224
Query: 258 PGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
G +++N ARGG+VD+ LA AL+ G + AA DV EP
Sbjct: 225 KGVYIINCARGGIVDENDLAEALQSGHVAGAASDVFVQEP 264
>UniRef50_Q8YIU3 Cluster: D-3-PHOSPHOGLYCERATE DEHYDROGENASE; n=75;
Bacteria|Rep: D-3-PHOSPHOGLYCERATE DEHYDROGENASE -
Brucella melitensis
Length = 538
Score = 136 bits (329), Expect = 1e-30
Identities = 82/232 (35%), Positives = 126/232 (54%), Gaps = 8/232 (3%)
Query: 66 KVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYG 125
+V+ E G + +T++ + K L+++ R G GVDN+D+ AA GI V N P
Sbjct: 46 EVIGEYDGLAIRSATKVTEKLIAAAKKLKVVGRAGIGVDNVDIPAASRRGIIVMNTPFGN 105
Query: 126 VEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGR 185
A+ + L+ + R+ R GK E+ R I G TLG+VG G
Sbjct: 106 SITTAEHAIALMFAVARQLPEADTSTRAGKW----EKNRFMGV---EITGKTLGVVGCGN 158
Query: 186 IGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNH 245
IGS VA R +V+ +DP+L D + LG+ +V L +LL ++D ++LH L +
Sbjct: 159 IGSIVATRGIGLKMHVVAFDPFLSDARAQELGVEKV-ELDELLARADFITLHTPLIDKTR 217
Query: 246 HLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++IN T+ +M+PG +VN ARGGL+ ++ L AALK G + A +DV+E EP
Sbjct: 218 NIINAQTLAKMKPGVRIVNCARGGLIVEKDLIAALKSGHVAGAGIDVYETEP 269
>UniRef50_Q5WLJ2 Cluster: D-3-phosphoglycerate dehydrogenase; n=2;
Bacillus|Rep: D-3-phosphoglycerate dehydrogenase -
Bacillus clausii (strain KSM-K16)
Length = 316
Score = 136 bits (329), Expect = 1e-30
Identities = 85/214 (39%), Positives = 116/214 (54%), Gaps = 10/214 (4%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
L + L+II + G GVDNIDV AA + G+ V NVP VAD L+L+L R+
Sbjct: 62 LAQLPDLKIIAKHGVGVDNIDVDAAKKHGVTVTNVPNANKHAVADFAFSLLLSLARQIPT 121
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
++GK S A + TLGI+GLG IG VA RA F V+ YDP
Sbjct: 122 GNEKTKKGKW---------PSLFGADVYQQTLGIIGLGAIGKEVARRASGFSMTVLAYDP 172
Query: 207 YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
Y+ + G+ V +L LL QSD V++H L HLI E ++ M+ A+LVN +
Sbjct: 173 YIDRTYARKNGIEAV-SLDALLQQSDFVTIHIPLLPETRHLIGERELQLMKKSAYLVNAS 231
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEPFNV 300
RGG+VD+ L AL+ ++ AALDV E EP ++
Sbjct: 232 RGGIVDETALYEALQTQQLAGAALDVFEEEPLHM 265
>UniRef50_A6C2G1 Cluster: Phosphoglycerate dehydrogenase; n=1;
Planctomyces maris DSM 8797|Rep: Phosphoglycerate
dehydrogenase - Planctomyces maris DSM 8797
Length = 316
Score = 136 bits (329), Expect = 1e-30
Identities = 86/220 (39%), Positives = 121/220 (55%), Gaps = 13/220 (5%)
Query: 83 TKEDLEKFKA---LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILN 139
TK D E A L+II R G+G+DN+D + A E GI VC P VA+ T+ L+L
Sbjct: 53 TKVDRELIDAAPELKIIARAGAGLDNVDTEYAHEKGIVVCFTPDANSLSVAELTIGLMLA 112
Query: 140 LYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGF 199
L R+ + E ++ T + G + G++GLGRIGS A RAKAFG
Sbjct: 113 LMRK-------IPEARQDTLTGGWNRLKFTGTELYGKSFGLIGLGRIGSFTATRAKAFGM 165
Query: 200 NVIFYDPYLP-DGIE-KSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMR 257
N++ DP+L D + K L T + +L DLL +SD VS H L ++ ++M+
Sbjct: 166 NILAADPFLKADAPQLKKLNAT-LLSLDDLLAESDVVSCHSPLTPDTRKMLTYQHFRKMK 224
Query: 258 PGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
P AF +NT+RG +VD+ GL AL + ++ AALDV E EP
Sbjct: 225 PDAFFINTSRGEVVDERGLTQALLEHKLAGAALDVRETEP 264
>UniRef50_Q9UYH9 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase; n=4; Thermococcaceae|Rep: D-isomer
specific 2-hydroxyacid dehydrogenase - Pyrococcus abyssi
Length = 333
Score = 136 bits (329), Expect = 1e-30
Identities = 82/252 (32%), Positives = 138/252 (54%), Gaps = 4/252 (1%)
Query: 46 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDN 105
LK V S E+ E ++ E G ++ +TK+ LE+ + L++I +G D+
Sbjct: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
Query: 106 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 165
+DV+ A + GI V V G E VA+ + L+++L R+ ++ + +REGK + RE
Sbjct: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
Query: 166 ASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQ 225
+ G +GIVG+G IG A+A R K FG + ++ + + IE+ + + L
Sbjct: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVN-AKYLDLD 195
Query: 226 DLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRI 285
+LL + D V L L + +H+INE +K++ G +LVN RG L+D++ L A+K+G++
Sbjct: 196 ELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKL 254
Query: 286 RAAALDVHENEP 297
+ A DV E EP
Sbjct: 255 KGFATDVFEEEP 266
>UniRef50_Q0W4A2 Cluster: D-3-phosphoglycerate dehydrogenase; n=11;
cellular organisms|Rep: D-3-phosphoglycerate
dehydrogenase - Uncultured methanogenic archaeon RC-I
Length = 526
Score = 136 bits (329), Expect = 1e-30
Identities = 75/216 (34%), Positives = 118/216 (54%), Gaps = 8/216 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+TKE + K L+II R G G+DN+DV AA E GI V N P + T+ ++L +
Sbjct: 54 VTKEVIAAGKNLKIIGRAGVGIDNVDVPAATEKGIIVANAPEGNTIAACEHTLSMMLAMS 113
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R ++ GK R G + TLGI+GLGRIG + RA++FG V
Sbjct: 114 RNIPQANASLKSGK------WERSKFMG-VEVMNKTLGIIGLGRIGGEITKRARSFGMEV 166
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ YDP+ + +G R+ TL ++ ++D +++H L H+++ ++M+ G
Sbjct: 167 LAYDPFTTAERAQQIG-ARLTTLDEIYEKADFITVHTPLTPSTKHMVSTAQFEKMKKGVR 225
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++N ARGG++D+ L A+K G++ AALDV E EP
Sbjct: 226 IINCARGGIIDEAALLEAIKSGKVAGAALDVFEKEP 261
>UniRef50_O58320 Cluster: Glyoxylate reductase; n=16; cellular
organisms|Rep: Glyoxylate reductase - Pyrococcus
horikoshii
Length = 334
Score = 136 bits (329), Expect = 1e-30
Identities = 84/218 (38%), Positives = 112/218 (51%), Gaps = 3/218 (1%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+ KE E LRI+ G DNID++ A + GI V N P + AD L+L
Sbjct: 57 IDKEVFENAPKLRIVANYAVGYDNIDIEEATKRGIYVTNTPDVLTDATADLAFALLLATA 116
Query: 142 RRTYWLANMVREGK-KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
R VR G+ K G + G + G T+GI+GLGRIG A+A RAK F
Sbjct: 117 RHVVKGDRFVRSGEWKKRGVAWHPKWFLGYD-VYGKTIGIIGLGRIGQAIAKRAKGFNMR 175
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
+++Y + +E+ L L+DLL +SD V L L +HLINE +K M+ A
Sbjct: 176 ILYYSRTRKEEVERELN-AEFKPLEDLLRESDFVVLAVPLTRETYHLINEERLKLMKKTA 234
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPF 298
L+N ARG +VD L ALK+G I A LDV E EP+
Sbjct: 235 ILINIARGKVVDTNALVKALKEGWIAGAGLDVFEEEPY 272
>UniRef50_A6GGA6 Cluster: Probable 2-hydroxyacid dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: Probable 2-hydroxyacid
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 327
Score = 136 bits (328), Expect = 2e-30
Identities = 88/211 (41%), Positives = 114/211 (54%), Gaps = 6/211 (2%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
L+ F LR++ + G DN+DV A I V N PG + AD M L+L+ R
Sbjct: 68 LDAFPELRVVSNMAVGFDNVDVPACTARSIRVGNTPGVLTDATADLAMALLLSAARNLPA 127
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
+ REG+ T G +RG TLG+VGLG+IG AVA RA+AFG +++ Y
Sbjct: 128 ASLDAREGRWQTWSPT---GWLGL-ELRGATLGVVGLGKIGLAVAQRARAFGMDIL-YTR 182
Query: 207 YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
LG TRV L LL ++D VSLH L HLI+ + +M+P A LVNTA
Sbjct: 183 RSDAPAPPELGATRV-ELDALLARADVVSLHVPLRPDTRHLIDAAALGRMKPSALLVNTA 241
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
RG +VD L AAL+ G+I AALDV EP
Sbjct: 242 RGDVVDQVALQAALEAGQIAGAALDVTSPEP 272
>UniRef50_A6C9V4 Cluster: Phosphoglycerate dehydrogenase; n=1;
Planctomyces maris DSM 8797|Rep: Phosphoglycerate
dehydrogenase - Planctomyces maris DSM 8797
Length = 541
Score = 136 bits (328), Expect = 2e-30
Identities = 87/239 (36%), Positives = 124/239 (51%), Gaps = 8/239 (3%)
Query: 59 STSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAV 118
S E+ E L A G ++ LT+E L+ L+ IVR G GVDNID AA GI V
Sbjct: 33 SPEEVRE-ALKSADGIIIRSATKLTEEVLKGQPRLKAIVRAGVGVDNIDRAAATREGIVV 91
Query: 119 CNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTL 178
N P A+ T+ L++ L R ++EGK R+ G ++ G TL
Sbjct: 92 MNTPAGNTTSTAEQTIALMMALARNIGPAYATMKEGK------WERKKLTG-TQVAGKTL 144
Query: 179 GIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHC 238
I+GLGRIG +VA RA+ VI YDP++ G+ + +L+ D +++H
Sbjct: 145 AIIGLGRIGLSVAHRAQGLEMKVIGYDPFMSAERAAEYGIELYKEVDELVKHCDFLTVHT 204
Query: 239 SLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L + LIN I MRPG ++N ARGG+V+++ LA AL+ G++ AA DV EP
Sbjct: 205 PLTDETRDLINAERIATMRPGVRIINCARGGIVNEDDLADALESGKVAGAACDVFTQEP 263
Score = 34.3 bits (75), Expect = 7.3
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 5/45 (11%)
Query: 322 CSVLLQQGP----LKDAPNLLCTPHAAFYSDASAQELREMAASEI 362
C V Q+ P L DAPN+L TPH +D AQE+ + A+EI
Sbjct: 256 CDVFTQEPPENRRLIDAPNMLATPHLGASTD-EAQEMVALEAAEI 299
>UniRef50_Q120S8 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=2; Proteobacteria|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Polaromonas sp. (strain JS666 / ATCC
BAA-500)
Length = 325
Score = 135 bits (327), Expect = 2e-30
Identities = 80/219 (36%), Positives = 117/219 (53%), Gaps = 16/219 (7%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+++ ++ + ++R G GVDNID+ AA IAV NVP YG +EV+ T+ L L +
Sbjct: 66 VSRRVIDAMDRCKAVIRYGIGVDNIDMAAAAARRIAVANVPDYGTDEVSTQTVALALAVV 125
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R+ VR G+ TG R+RG TLG++G GRI + FGF
Sbjct: 126 RQVVSHDREVRSGRWSTG------VIKPMYRLRGRTLGLIGYGRIARMTHEKFSGFGFGR 179
Query: 202 IFYD---PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRP 258
+ + P LPDG++ + + D+ ++D +SLH L H+I+ + MRP
Sbjct: 180 VLVNDPCPELPDGVQAA-------DVDDICREADIISLHAPLTAQTRHIIDARRLGLMRP 232
Query: 259 GAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
A +VNT+RGGL+D + L AL +GRI A LDV E EP
Sbjct: 233 TAIVVNTSRGGLIDLDALYRALSEGRILGAGLDVFETEP 271
>UniRef50_A0LMX1 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep:
D-3-phosphoglycerate dehydrogenase - Syntrophobacter
fumaroxidans (strain DSM 10017 / MPOB)
Length = 525
Score = 135 bits (327), Expect = 2e-30
Identities = 84/220 (38%), Positives = 119/220 (54%), Gaps = 16/220 (7%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T E +E L++I R G+GVDNIDVKAA G V N PG A+ T+ ++L L
Sbjct: 54 ITAELIENAPRLKVIGRAGTGVDNIDVKAASARGALVMNTPGANATAAAEHTIAMMLALA 113
Query: 142 RRTYWLANMVREG----KKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAF 197
R +REG K+F G E + TLGI+GLG+IGS VA RA +
Sbjct: 114 RHIPQATQSMREGRWDKKRFMGTELFHQ-----------TLGIIGLGKIGSIVADRALSM 162
Query: 198 GFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMR 257
+V+ +DPY+ LG+ V L +LL +SD ++LH ++N T+ + +
Sbjct: 163 KMDVLGHDPYIIPEAAAILGVEWV-PLDELLARSDFLTLHTPSTSETVRILNRETLARTK 221
Query: 258 PGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
PG ++N ARGGL+D++ L L G + AALDV E EP
Sbjct: 222 PGVRILNCARGGLIDEQALYEFLLNGHVGGAALDVFEQEP 261
>UniRef50_A3ZW64 Cluster: Phosphoglycerate dehydrogenase, putative;
n=1; Blastopirellula marina DSM 3645|Rep:
Phosphoglycerate dehydrogenase, putative -
Blastopirellula marina DSM 3645
Length = 320
Score = 135 bits (326), Expect = 3e-30
Identities = 82/207 (39%), Positives = 116/207 (56%), Gaps = 12/207 (5%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
+R++ R+G G D+++V AA E IAVC PG + V + T+ +IL +YR N++
Sbjct: 66 VRVVSRVGVGYDSVNVPAATEQNIAVCRTPGTLHQSVVEHTIGMILAIYR------NVIS 119
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
+ K+ + R A R G TLGI+G G IG VA A G VI YDP P G
Sbjct: 120 QNKQVRAGDWDRTAGP---RAYGKTLGIIGYGVIGKEVAKAAVLLGMQVIAYDPIAPAGG 176
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
+ RV L ++ +SD VSLH +IN ++ M+ A L+NT+RGGLV+
Sbjct: 177 PSEV--ERV-ALDEIWRRSDVVSLHAPCTPETERIINAQSLALMKDDALLINTSRGGLVN 233
Query: 273 DEGLAAALKQGRIRAAALDVHENEPFN 299
+ LAAA+K G++R AALDV E EP +
Sbjct: 234 EPELAAAMKGGKLRGAALDVFEQEPID 260
>UniRef50_A1ZGW5 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Microscilla marina ATCC 23134|Rep: D-3-phosphoglycerate
dehydrogenase - Microscilla marina ATCC 23134
Length = 322
Score = 135 bits (326), Expect = 3e-30
Identities = 102/284 (35%), Positives = 150/284 (52%), Gaps = 25/284 (8%)
Query: 29 PLVALLDGRDCTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHT---II---- 81
P+V +DG EMP L A+ + + E LNEA+ A+ H+ I+
Sbjct: 5 PIVLKIDGATY-FEMPQLDGYL------AKHQTRLVEASLNEAISAINEHSPGAIVSGAA 57
Query: 82 -LTKE--DLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLIL 138
+ +E D K LR IV+ G+G+DNID + A I V N+P Y E VA+ + L+L
Sbjct: 58 PIGREIMDAGLQKGLRGIVKAGTGLDNIDCEYARCQQILVENIPDYVHETVAEYAINLML 117
Query: 139 NLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFG 198
+L R+++ + +R+ F + AS G + G T+G+VG GRI +VA R FG
Sbjct: 118 SLARKSWPVQQTMRQKGWF----DITPASLG-TELNGKTIGLVGFGRIARSVA-RIAHFG 171
Query: 199 F--NVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQM 256
F +VI YDPY+ + + + L+D+L D VSLH SLN +LI E + M
Sbjct: 172 FQMSVIAYDPYVSAEEMELCAVQKAEQLEDILPHCDVVSLHTSLNNDTRNLIGEKQLAMM 231
Query: 257 RPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNV 300
+ A L+N ARGG++D+ L AL +I ALDV+ EP +V
Sbjct: 232 KSSALLINVARGGIIDETALLIALSTQKIGGVALDVYSQEPLDV 275
>UniRef50_A1W9A3 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Acidovorax sp.
JS42|Rep: D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Acidovorax sp. (strain JS42)
Length = 339
Score = 135 bits (326), Expect = 3e-30
Identities = 93/284 (32%), Positives = 130/284 (45%), Gaps = 17/284 (5%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
L LR++ +G D+ID++A + GIAVC+VP YG VA+ L+L + R
Sbjct: 66 LRMLPRLRLVATRSAGFDHIDLEACRKRGIAVCHVPDYGSASVAEHAFALLLGVTRHLTQ 125
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
R+G G + G TLGIVGLGRIG VA A FG +V+ YDP
Sbjct: 126 AHERARQGSF------AYRGLTGF-ELEGRTLGIVGLGRIGRHVARIAVGFGMDVLAYDP 178
Query: 207 YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
+ G++ V T + +L SD +SLH E HLI+ +M+PG ++NTA
Sbjct: 179 AFAASAARPAGVSLV-TWEQVLQGSDILSLHVPATEATRHLIDARAFARMKPGVVVINTA 237
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLL 326
RG L+D+ L AL G + AA LDV E E P + +
Sbjct: 238 RGALIDEAALLRALDDGSVAAAGLDVLEQE---------GALSPEVPTGCGGLGCDTGWM 288
Query: 327 QQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRI 370
PL P +L TPH F + + + + S I GR+
Sbjct: 289 ASSPLLTHPRVLVTPHVGFNTTEAIARIFDETISNIAAWHAGRL 332
>UniRef50_Q46VE6 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, catalytic region:D- isomer specific
2-hydroxyacid dehydrogenase, NAD-binding; n=6;
Proteobacteria|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, catalytic region:D- isomer specific
2-hydroxyacid dehydrogenase, NAD-binding - Ralstonia
eutropha (strain JMP134) (Alcaligenes eutrophus)
Length = 312
Score = 134 bits (325), Expect = 4e-30
Identities = 90/212 (42%), Positives = 112/212 (52%), Gaps = 7/212 (3%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
LE+ ALR++ R+G G+DNIDV A + GI V G VA+ + L R Y
Sbjct: 61 LERAPALRVVGRLGVGLDNIDVAACRDRGIRVIPASGANARSVAEYVVTTAALLLRGAYL 120
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
+ V GK P S G + G TLG++G G IG A A+AFG V+ +DP
Sbjct: 121 GSAEVAGGK---WPRA--RLSEGREAL-GKTLGLIGFGDIGRQAAALAQAFGMRVVAHDP 174
Query: 207 YL-PDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNT 265
L PD S TL LL QSD VSLH L HL+N I M+ GA L+NT
Sbjct: 175 MLAPDDPVWSATGVVCMTLDALLAQSDAVSLHVPLVAATRHLMNAQRIGAMKRGAVLINT 234
Query: 266 ARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
ARGG+VD+ LA AL +G + AALDV E EP
Sbjct: 235 ARGGVVDEGALAGALLEGHLAGAALDVFEAEP 266
>UniRef50_O14465 Cluster: D-mandelate dehydrogenase; n=1;
Rhodotorula graminis|Rep: D-mandelate dehydrogenase -
Rhodotorula graminis (Yeast)
Length = 351
Score = 134 bits (325), Expect = 4e-30
Identities = 77/208 (37%), Positives = 112/208 (53%), Gaps = 2/208 (0%)
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
+L++ G+G D +D+ A E G+A N G G +D + LIL+++R +
Sbjct: 80 SLKVFAAAGAGFDWLDLDALNERGVAFANSRGAGDTATSDLALYLILSVFRLASYSERAA 139
Query: 152 REGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRA-KAFGFNVIFYDPYLPD 210
R G T E RG LG VGLG I +A +A G +++YD D
Sbjct: 140 RTGDPETFNRVHLEIGKSAHNPRGHVLGAVGLGAIQKEIARKAVHGLGMKLVYYDVAPAD 199
Query: 211 G-IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGG 269
EK+LG RV +L++L +SDCVS+ + HHLI+E M+PG+ +VNTARG
Sbjct: 200 AETEKALGAERVDSLEELARRSDCVSVSVPYMKLTHHLIDEAFFAAMKPGSRIVNTARGP 259
Query: 270 LVDDEGLAAALKQGRIRAAALDVHENEP 297
++ + L AALK G++ +A LDVHE EP
Sbjct: 260 VISQDALIAALKSGKLLSAGLDVHEFEP 287
>UniRef50_UPI00015B605A Cluster: PREDICTED: similar to GA19489-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
GA19489-PA - Nasonia vitripennis
Length = 511
Score = 134 bits (324), Expect = 5e-30
Identities = 77/205 (37%), Positives = 112/205 (54%), Gaps = 8/205 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L+++ R G+GVDNID+ AA GI V N PG + T +I L R N+V+
Sbjct: 69 LKLVGRAGTGVDNIDIPAATRNGILVLNTPGGNSVSACELTCAVISALAR------NVVQ 122
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
G+ R+ AG + G LG+VG GRIG VA R KAFG +I YDP+
Sbjct: 123 AGQSMKEGRWDRKLYAG-RELSGKALGVVGFGRIGREVAHRMKAFGMEIIAYDPFFTKEQ 181
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
+G+T+ L+D+ +D +++H L +LIN T+ + + G ++VN ARGG+VD
Sbjct: 182 AAQIGVTKG-ELEDIWKNADYITVHTPLIPQTKNLINATTLAKCKKGVYIVNVARGGIVD 240
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
+E L ++ G + AALDV EP
Sbjct: 241 EEALLHSINAGHVAGAALDVFIEEP 265
>UniRef50_Q6MN05 Cluster: Phosphoglycerate dehydrogenase; n=1;
Bdellovibrio bacteriovorus|Rep: Phosphoglycerate
dehydrogenase - Bdellovibrio bacteriovorus
Length = 328
Score = 134 bits (324), Expect = 5e-30
Identities = 76/218 (34%), Positives = 121/218 (55%), Gaps = 8/218 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+ +E L+K + L++IV SG D+ID++A + G+ V + P +E A T L+L+
Sbjct: 55 IDEELLKKARQLQLIVTCTSGFDHIDLEATQKWGVTVMHTPTANIESAAQLTWGLVLSCV 114
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
MV+ G E R+ G + G GIVGLGRIGS VA A+AFG NV
Sbjct: 115 NNIQAAHKMVKAG------EWNRDQITGI-ELAGRNYGIVGLGRIGSRVAELAQAFGMNV 167
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ YDPY D + + L + R+ + +++L +D +S H H++N + + G
Sbjct: 168 VAYDPYQEDEVFERLHIPRL-SYEEVLKTADVISFHVPKTLETEHMLNRSQFEYIHRGIV 226
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFN 299
L+NT+RG ++++ L AL++G +R+ LDV+E EP N
Sbjct: 227 LINTSRGSVINENDLCEALEKGWLRSVGLDVYEKEPLN 264
>UniRef50_A4FIF2 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
D-3-phosphoglycerate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 316
Score = 134 bits (324), Expect = 5e-30
Identities = 87/219 (39%), Positives = 114/219 (52%), Gaps = 14/219 (6%)
Query: 81 ILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNL 140
++T E +E LR+I + G GVDNID+ AA GI V PG VA+ T L++
Sbjct: 59 LVTAEVIEAGPRLRVIAKHGVGVDNIDLDAARARGIPVVFAPGSNSRAVAELTFGLMIAA 118
Query: 141 YRRTYWLANMVREGK--KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFG 198
RR V G K GPE + G TLG++G GRIG +A A+AFG
Sbjct: 119 ARRIAAAHTAVVAGDWPKLYGPE-----------LAGRTLGVIGFGRIGRLLAGYAQAFG 167
Query: 199 FNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRP 258
V+ YDP+L DG G+ R + + L SD VSLH L+++ ++ M+P
Sbjct: 168 MTVVGYDPFLDDGELTERGV-RPVSFSECLAMSDFVSLHLPAEPGRPPLLDQRALRTMKP 226
Query: 259 GAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
GA LVN ARGGLVD+ LA L G + AAA D EP
Sbjct: 227 GACLVNAARGGLVDESALAELLHSGHLGAAACDAFATEP 265
Score = 36.3 bits (80), Expect = 1.8
Identities = 16/46 (34%), Positives = 25/46 (54%)
Query: 326 LQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIP 371
L PL+ APN+L TPH S + +++ M A ++ R + G P
Sbjct: 266 LADSPLRTAPNVLLTPHIGACSHEANRDMGVMVAQDVARVLRGEQP 311
>UniRef50_P44501 Cluster: 2-hydroxyacid dehydrogenase homolog; n=51;
Bacteria|Rep: 2-hydroxyacid dehydrogenase homolog -
Haemophilus influenzae
Length = 331
Score = 134 bits (324), Expect = 5e-30
Identities = 81/216 (37%), Positives = 122/216 (56%), Gaps = 11/216 (5%)
Query: 83 TKEDLEKFKAL--RIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNL 140
+++ LEK AL +I+ +G +N+D+KAA ELGI V VP Y E VA+ T+ L++ L
Sbjct: 57 SRKVLEKLAALGVKIVALRCAGFNNVDLKAAQELGIQVVRVPAYSPEAVAEHTIGLMMTL 116
Query: 141 YRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
RR + RE F+ E G + G T+G++G G+IG AV K FG N
Sbjct: 117 NRRIHRAYQRTREAN-FS-----LEGLIGF-NMYGRTVGVIGTGKIGIAVMRILKGFGMN 169
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
++ YDP+ +E+ G + L +L +S ++LHC N+HL+N +M+ G
Sbjct: 170 ILAYDPFKNPVVEELGG--QYVELDELYAKSHVITLHCPATPENYHLLNCEAFAKMKDGV 227
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
+VNT+RG L+D + ALKQ +I A +DV+ENE
Sbjct: 228 MIVNTSRGSLIDTQAAIDALKQRKIGALGMDVYENE 263
>UniRef50_Q3KBX8 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=2; Pseudomonas|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Pseudomonas fluorescens (strain PfO-1)
Length = 324
Score = 134 bits (323), Expect = 7e-30
Identities = 98/308 (31%), Positives = 146/308 (47%), Gaps = 31/308 (10%)
Query: 64 HEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPG 123
+ ++ NE V A+ ++ E + LRI+ R G+G DN+D KAA ELG+ V N PG
Sbjct: 35 YSEIQNE-VDAVFLRGGHISAEMIAASPKLRIVARHGAGYDNVDYKAAAELGVWVTNTPG 93
Query: 124 YGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGL 183
V + L+L + R+ + R Q R + G + G TLG++G
Sbjct: 94 ANRRSVVEHVFALLLGISRKVQLATDQTRNNIW----AQDRLSLTGI-ELEGRTLGLIGF 148
Query: 184 GRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEH 243
G IG VA A+AFG V+ DP +K R+ L LL Q+D VSLH L E
Sbjct: 149 GDIGRHVAPVAEAFGMKVLATDPAYDTSFDK-----RLVDLDTLLTQADVVSLHVPLQEG 203
Query: 244 NHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQA 303
+LI+ I++M+ GA L+NT+RGG++D+ +A AL+ G++ A +DV E ++
Sbjct: 204 TENLISRAEIEKMKTGAILINTSRGGVIDEAAVADALRSGKLGGAGIDVLAAENTDMITP 263
Query: 304 YLNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIR 363
+ P+ D PNLL TPH A ++ S + A I
Sbjct: 264 F--------------------SYNTFPVADLPNLLVTPHVAGQTNESLLRVGMSAVKAIS 303
Query: 364 RAIVGRIP 371
+ G P
Sbjct: 304 AVLRGAPP 311
>UniRef50_A1W7V5 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=2; Proteobacteria|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Acidovorax sp. (strain JS42)
Length = 337
Score = 134 bits (323), Expect = 7e-30
Identities = 94/281 (33%), Positives = 133/281 (47%), Gaps = 13/281 (4%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
LT E L +F LR+I +G D+ID+ GIAV NVP YG VA+ L+L +
Sbjct: 54 LTAEVLAQFPRLRLIATRSTGYDHIDLDYCRAHGIAVSNVPDYGDATVAEHAFALLLAVS 113
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R A R G F+ + G +RG TLG++G GRIG V K FG +
Sbjct: 114 RHIVTGAERTRRGD-FS-----QHGLRGF-ELRGKTLGVLGTGRIGRRVIEIGKGFGMKI 166
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ YD + + + LG + L LL Q+D V+LH HHL+ + M+ GA
Sbjct: 167 VAYDLFPDAAVAEHLGYEYL-DLHVLLSQADVVTLHVPATPQTHHLLGDPEFAAMKKGAV 225
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXX 321
L+NTARGG+VD L AL ++RAA LDV EP +A +
Sbjct: 226 LINTARGGVVDTSALVRALSARKLRAAGLDVLPAEPLIREEAEI-----FRNDRRNSDTD 280
Query: 322 CSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEI 362
LL L N++ TPH A+ +D + + + + + I
Sbjct: 281 LRALLADHVLLRFSNVIVTPHVAYDTDEALRRILDTTIANI 321
>UniRef50_A1DFM4 Cluster: D-3-phosphoglycerate dehydrogenase; n=10;
Fungi/Metazoa group|Rep: D-3-phosphoglycerate
dehydrogenase - Neosartorya fischeri (strain ATCC 1020 /
DSM 3700 / NRRL 181)(Aspergillus fischerianus (strain
ATCC 1020 / DSM 3700 / NRRL 181))
Length = 582
Score = 134 bits (323), Expect = 7e-30
Identities = 74/211 (35%), Positives = 115/211 (54%), Gaps = 7/211 (3%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
L K L+++ R G GVDN+DV+ A +LGI V N P + A+ T+ L++ + R
Sbjct: 65 LRAAKQLKVVARAGVGVDNVDVEEATKLGIVVVNSPSGNIGAAAEHTIALLIAMARNIPE 124
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
+ ++ GK R G ++G TL I+GLG++G VA AK G NV DP
Sbjct: 125 ACSSLKSGK------WERSKFVG-VEVKGKTLSIIGLGKVGLTVARLAKGLGMNVNALDP 177
Query: 207 YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
Y + S +T V +L +LL +D +++H L +I+ + QM+PG+ ++N A
Sbjct: 178 YASPAVAVSASVTLVSSLSELLPTADFLTIHTPLIASTKGMISTAELAQMKPGSRILNVA 237
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
RGG +D+ L +L+ G + AAA+DV EP
Sbjct: 238 RGGTIDEAALLQSLESGHLAAAAIDVFTTEP 268
>UniRef50_Q8PW48 Cluster: D-3-phosphoglycerate dehydrogenase; n=4;
Methanomicrobia|Rep: D-3-phosphoglycerate dehydrogenase
- Methanosarcina mazei (Methanosarcina frisia)
Length = 540
Score = 134 bits (323), Expect = 7e-30
Identities = 79/255 (30%), Positives = 138/255 (54%), Gaps = 9/255 (3%)
Query: 43 MPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSG 102
+ ILK+ + C E+ EK+ + T + T+ +E L+II R G G
Sbjct: 31 LEILKEHFDIDVCTGLCEDELVEKIKGYDALVIRSGTQV-TQRIIEAADNLKIIGRAGVG 89
Query: 103 VDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQ 162
VDN+DV AA + GI V N P + A+ T+ +++++ R N+ + E
Sbjct: 90 VDNVDVDAATKKGIIVANAPEGNMISAAEHTIAMMMSMSR------NIPQANASLKAREW 143
Query: 163 VREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVY 222
R G ++G TLG++GLGRIGS VA RA N++ YDP++ + LG+ ++
Sbjct: 144 KRNKFMG-VEVKGKTLGVIGLGRIGSEVAKRAAGLEMNLMGYDPFISEKRAMELGV-KLA 201
Query: 223 TLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQ 282
T+ ++ ++D +++H L + +++++ M+ G ++N ARGG++++E LA AL+
Sbjct: 202 TVNEIAKEADYITVHTPLIKETRNILDDEQFALMKKGVRVLNCARGGIINEEALARALES 261
Query: 283 GRIRAAALDVHENEP 297
G++ AA+DV EP
Sbjct: 262 GKVGGAAIDVFVEEP 276
>UniRef50_Q3AQU0 Cluster: D-3-phosphoglycerate dehydrogenase; n=5;
Chlorobium/Pelodictyon group|Rep: D-3-phosphoglycerate
dehydrogenase - Chlorobium chlorochromatii (strain CaD3)
Length = 538
Score = 133 bits (321), Expect = 1e-29
Identities = 77/216 (35%), Positives = 118/216 (54%), Gaps = 8/216 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
L E L K L +I R G+GVDNID++AA GI V + PG A+ T ++L
Sbjct: 65 LPAEVLAKATQLELIGRAGTGVDNIDLEAATRQGIVVMSTPGGNAVSAAEHTCAMLLAAA 124
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R +++G + AG + G TL ++GLGR+G VA+R +AFG
Sbjct: 125 RHIPQAMADLKQGN------WNKHLYAGI-ELEGKTLSLIGLGRVGREVAMRMQAFGMRT 177
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
I YDP + D L + + L + L ++D +++H +L+E ++L+ + T+ +PG
Sbjct: 178 IAYDPAIADEDAALLDI-ELLPLHENLLRADVITIHSALDESTYNLLGKETLSLTKPGVI 236
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+VN ARGG++++ LA AL G + AAALDV EP
Sbjct: 237 IVNCARGGIINEVALAEALASGHVAAAALDVFTKEP 272
>UniRef50_A3ZMM2 Cluster: Dehydrogenase; n=1; Blastopirellula marina
DSM 3645|Rep: Dehydrogenase - Blastopirellula marina DSM
3645
Length = 321
Score = 133 bits (321), Expect = 1e-29
Identities = 112/342 (32%), Positives = 163/342 (47%), Gaps = 41/342 (11%)
Query: 37 RDCTVEMPILKDVATVAFCDAQSTSE--IHEKVLNEAVGALMWHTIILTKEDLEKFKALR 94
+D +E L D A V A T E + V A++ + +T + + L+
Sbjct: 14 QDLEIEHKTL-DKAGVELIVATHTDENALATLAAEHQVDAILTNWANVTAKVIAASPNLK 72
Query: 95 IIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREG 154
I+ R+G G+DNIDV + I V N+P Y V EVA+ T+ L+L R+ +A E
Sbjct: 73 IVARLGIGLDNIDVAYCTQQKIPVTNIPDYCVIEVAEHTLALLLACARK---IAMYHHET 129
Query: 155 KKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEK 214
+ T Q A R+ G TLGIVGLG+IG +A RA A G VI K
Sbjct: 130 QSGTYDLQ---AGPLMRRVSGQTLGIVGLGQIGVLLAERALALGLKVI-----ATSRSGK 181
Query: 215 SLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDE 274
++ L+ +L +SD +SL H+ ++M+ A+L+NTARG LVD+E
Sbjct: 182 TMPGVETVDLERILSESDYISLLIPATAETRHMFGAEEFQKMKSTAYLINTARGALVDEE 241
Query: 275 GLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDA 334
LAAAL+ ++ AALDV + EP C L + P+ D
Sbjct: 242 ALAAALEANQLAGAALDVQDPEP------------------------CD--LTKPPMND- 274
Query: 335 PNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRN 376
P ++ TPHAAF S S + LR A ++ + GR P+ +RN
Sbjct: 275 PRVIVTPHAAFVSVESLENLRGRATKQVVDLLEGRTPENVRN 316
>UniRef50_A0QQ27 Cluster: Glyoxylate reductase; n=4;
Mycobacterium|Rep: Glyoxylate reductase - Mycobacterium
smegmatis (strain ATCC 700084 / mc(2)155)
Length = 322
Score = 133 bits (321), Expect = 1e-29
Identities = 88/251 (35%), Positives = 128/251 (50%), Gaps = 13/251 (5%)
Query: 48 DVATVAFCDAQSTSEIHEKVLNEAVGALMWHTII-LTKEDLEKFKALRIIVRIGSGVDNI 106
D V FC + E + L +A ++WH + +T +DL + LR++ ++G+GV+ I
Sbjct: 29 DWLDVRFC-GEEDDETFYRELGDA--DVLWHVLRPITGDDLNRAPRLRLVHKLGAGVNTI 85
Query: 107 DVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREA 166
DV+ A +LGI V N+PG VA+ T+ L+L RR L R G+ + + +
Sbjct: 86 DVETATQLGILVANMPGANAPSVAEGTVLLMLAALRRLPQLDRATRAGRGWPTDPTLGDT 145
Query: 167 SAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQD 226
I G T+G+VG G + V A G + + + G R L D
Sbjct: 146 VRD---IGGCTVGLVGYGNVAKRVERIVLAMGAEQVLHTS------TRDTGHPRWRNLPD 196
Query: 227 LLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIR 286
LL SD VSLH L + + L+ I M+PGA LVNTARG +VD+ L AL+ GR+
Sbjct: 197 LLAASDIVSLHLPLTDTSRGLLGPEAIAAMKPGAVLVNTARGPIVDEAALIEALRGGRLA 256
Query: 287 AAALDVHENEP 297
AA LDV + EP
Sbjct: 257 AAGLDVFDTEP 267
>UniRef50_UPI00015BD3AA Cluster: UPI00015BD3AA related cluster; n=1;
unknown|Rep: UPI00015BD3AA UniRef100 entry - unknown
Length = 332
Score = 132 bits (320), Expect = 2e-29
Identities = 88/273 (32%), Positives = 138/273 (50%), Gaps = 16/273 (5%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
++K+ ++ L++I +G D+IDV A GI VCNVP YG E V++ + L+L L
Sbjct: 55 ISKDVIDSLPDLKLIATRSTGFDHIDVAYANSKGITVCNVPSYGEESVSEYAIMLMLALA 114
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R+ + V +G T + E + G TLG++G GRIG+ AL A+ FG +V
Sbjct: 115 RKLRETIDNVEKGVYKTSNLRGIE-------LAGKTLGVIGTGRIGARTALLARCFGMDV 167
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ YD + I G+ + +LL SD ++LH HHLIN IK + G+F
Sbjct: 168 VCYDAR-QNQILIDAGI-KYLDFNELLSVSDFITLHVPYLPSTHHLINMDNIKLFKKGSF 225
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXX 321
L+NT+RG +V+ E + LKQ + AA+D E+E V + +L +
Sbjct: 226 LINTSRGKVVETESVIYGLKQKILAGAAIDTFESEEV-VMEEHLLWNENLSAETLKKALE 284
Query: 322 CSVLLQQGPLKDAPNLLCTPHAAFYSDASAQEL 354
+ LL+ PN++ TPH A+ + Q +
Sbjct: 285 INYLLKH------PNVIITPHNAYNTKEGLQRI 311
>UniRef50_P52643 Cluster: D-lactate dehydrogenase; n=118; cellular
organisms|Rep: D-lactate dehydrogenase - Escherichia
coli (strain K12)
Length = 329
Score = 132 bits (319), Expect = 2e-29
Identities = 78/212 (36%), Positives = 117/212 (55%), Gaps = 10/212 (4%)
Query: 85 EDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRT 144
E+L+K I +R +G +N+D+ AA ELG+ V VP Y E VA+ + +++ L RR
Sbjct: 62 EELKKHGVKYIALRC-AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120
Query: 145 YWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFY 204
+ R+ F+ E G + G T G++G G+IG A+ K FG ++ +
Sbjct: 121 HRAYQRTRDAN-FS-----LEGLTGFT-MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173
Query: 205 DPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVN 264
DPY P LG+ V L L +SD +SLHC L N+HL+NE +QM+ G +VN
Sbjct: 174 DPY-PSAAALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVN 231
Query: 265 TARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
T+RG L+D + ALK +I + +DV+ENE
Sbjct: 232 TSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263
>UniRef50_UPI000023EBBC Cluster: hypothetical protein FG00146.1; n=1;
Gibberella zeae PH-1|Rep: hypothetical protein FG00146.1
- Gibberella zeae PH-1
Length = 1068
Score = 132 bits (318), Expect = 3e-29
Identities = 83/227 (36%), Positives = 122/227 (53%), Gaps = 8/227 (3%)
Query: 74 ALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTT 133
A++ +T++DL LR+I + G G+D IDV+A + VCN PG VA+ T
Sbjct: 794 AILIKDYYITEDDLASAPQLRVIGKQGVGLDKIDVEACKRHNVKVCNTPGVNASAVAEMT 853
Query: 134 MCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA-L 192
+CL L + R + ++R+ K G +E AG R +G+VG+G IG A+A +
Sbjct: 854 LCLALTVAREVPDV--VIRQ--KIQGEAIRKETVAGMLLSR-KIIGVVGMGHIGQAIAQM 908
Query: 193 RAKAFGFNVIFYDPYLPD--GIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINE 250
+I +DPY D G ++ RV TL +LL +D V+LH L ++I
Sbjct: 909 FVGGLQAEIIAFDPYFHDNQGPWDTIPYKRVETLTELLEVADVVTLHVPLTHSTKNMIAA 968
Query: 251 FTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+KQM+ A L+NTARGG+V++E LA AL +G I A D H EP
Sbjct: 969 PQLKQMKKTAILINTARGGIVNEEDLADALDKGEIWGAGFDCHCEEP 1015
>UniRef50_Q3ZX05 Cluster: D-3-phosphoglycerate dehydrogenase; n=3;
Dehalococcoides|Rep: D-3-phosphoglycerate dehydrogenase
- Dehalococcoides sp. (strain CBDB1)
Length = 526
Score = 132 bits (318), Expect = 3e-29
Identities = 86/252 (34%), Positives = 130/252 (51%), Gaps = 9/252 (3%)
Query: 46 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDN 105
LK++A V E+ ++ E L+ +T + + K L++I R G GVDN
Sbjct: 18 LKEIAQVDVKTGLKPEELIS-IIGEYDALLVRSQTQVTADIINAGKKLQVIGRAGVGVDN 76
Query: 106 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 165
ID+K A GI V N P + T+ L+L + R ++ R + R
Sbjct: 77 IDLKTATGNGIIVVNAPTGNTISATEHTLALMLAMAR------HIPRANASLKSGQWKRN 130
Query: 166 ASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQ 225
G + ++G TLGIVGLG IGS +A RA A VI YDP++ K L + + +
Sbjct: 131 EFVG-SELKGKTLGIVGLGNIGSEIAKRALALEMRVIGYDPFISMERAKKLQV-ELLPFE 188
Query: 226 DLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRI 285
DLL ++D ++LH + LI ++ M+P L+NT+RGG++D+E LA A+K+ RI
Sbjct: 189 DLLKRADFITLHVPMTGQTKGLIGPKELEMMKPTVRLINTSRGGIIDEEALAKAVKEKRI 248
Query: 286 RAAALDVHENEP 297
AA+DV EP
Sbjct: 249 GGAAIDVFSKEP 260
>UniRef50_A4MA79 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Petrotoga mobilis
SJ95|Rep: D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Petrotoga mobilis SJ95
Length = 310
Score = 132 bits (318), Expect = 3e-29
Identities = 77/216 (35%), Positives = 111/216 (51%), Gaps = 7/216 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+TKE LE L+I+ R G G+DNIDV A GI V N PG VA+ + ++L++Y
Sbjct: 54 VTKEILEHADKLKIVARAGMGLDNIDVDTAKLKGITVLNTPGQNSLSVAELVIGMVLDIY 113
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R + G EQ + + T GI+G G +G +A K F N
Sbjct: 114 RH-------ITRGTIGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLKGFQTNT 166
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ YD + E+ R +L++LL SD +SLH NE +H I+E IK M+ GA
Sbjct: 167 LVYDVFEISAEEQKNYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAV 226
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++N ARGG++D+ + LK G++ LDV E EP
Sbjct: 227 IINAARGGVLDENYVLKYLKNGKLLGVGLDVFEEEP 262
>UniRef50_Q97F10 Cluster: Possible phosphoglycerate dehydrogenase;
n=10; Bacteria|Rep: Possible phosphoglycerate
dehydrogenase - Clostridium acetobutylicum
Length = 324
Score = 131 bits (317), Expect = 3e-29
Identities = 79/240 (32%), Positives = 128/240 (53%), Gaps = 5/240 (2%)
Query: 60 TSEIHEKVLNEA--VGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIA 117
T + EK + A A++ + I+T + +EK L+ I + +G + +D++ A + GI
Sbjct: 36 TGKEEEKTIERARDAEAILTNKTIITSKVIEKLPKLKYIGVLATGYNVVDLEFAKKKGIV 95
Query: 118 VCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDT 177
V N+P Y V +M LIL + V++G + + G T
Sbjct: 96 VTNIPQYSTSSVVQMSMALILEICGHVGQHNASVKKGD-WQNCADFSYLKYPIIELSGKT 154
Query: 178 LGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLH 237
+G+VG G IG A+ A+A G V Y P+ PD ++ + V +L L ++D +SLH
Sbjct: 155 IGLVGYGSIGKAMQKAAEALGMKVFVYTPH-PDKKYENESMKFV-SLDTLFKEADVISLH 212
Query: 238 CSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
C L + N +IN+ +IK+M+ G ++NTARGGL+++ L ALK+ ++ AAALDV EP
Sbjct: 213 CPLKDDNKEMINKASIKKMKNGVIIINTARGGLINERDLYEALKENKVYAAALDVVSFEP 272
>UniRef50_Q74CK1 Cluster: Glycerate dehydrogenase; n=12;
Bacteria|Rep: Glycerate dehydrogenase - Geobacter
sulfurreducens
Length = 327
Score = 131 bits (317), Expect = 3e-29
Identities = 80/218 (36%), Positives = 112/218 (51%), Gaps = 3/218 (1%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
L + L LR I + +G +N+DV+AAG+ GI V N+P Y E V TT L+L L
Sbjct: 59 LDEATLAALPKLRYISMLATGYNNVDVEAAGKRGIPVANIPAYSTESVVQTTFALLLELA 118
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
+ V+ + P+ + + G TLGIVG G IG AVA AFG +
Sbjct: 119 VHVGIHDSAVKAREWVRSPDHSFWKTP-IVELDGLTLGIVGYGTIGRAVARVGAAFGMKI 177
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ Y P +P + R +L +L SD VSL+C N +N + M+P AF
Sbjct: 178 MAYAPRVPADLGPVP--VRFVSLDELFAGSDVVSLNCPQTAENTGFVNSRLLSLMKPSAF 235
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFN 299
+N ARGGLV++ LAAAL G++ A LDV +EP +
Sbjct: 236 FLNVARGGLVNEVDLAAALHSGKLAGAGLDVVAHEPMS 273
>UniRef50_Q72KT6 Cluster: Glycerate dehydrogenase/glyoxylate
reductase; n=2; Thermus thermophilus|Rep: Glycerate
dehydrogenase/glyoxylate reductase - Thermus
thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Length = 338
Score = 131 bits (317), Expect = 3e-29
Identities = 89/233 (38%), Positives = 126/233 (54%), Gaps = 13/233 (5%)
Query: 66 KVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYG 125
K + AVG + + E +++ K L++I GVD++D++AA E GI V + PG
Sbjct: 66 KRVEGAVGLIPTVEDRIDAEVMDRAKGLKVIACYSVGVDHVDLEAARERGIRVTHTPGVL 125
Query: 126 VEEVADTTMCLILNLYRRTYWLANMVREGK-KFTGPEQVREASAGCARIRGDTLGIVGLG 184
E AD T+ L+L + RR A R+G + PE + ++G TLG+VG+G
Sbjct: 126 TEATADLTLALLLAVARRVVEGAAYARDGLWRAWHPELLLGLD-----LQGLTLGLVGMG 180
Query: 185 RIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHN 244
RIG AVA RA AFG V+ Y P + +L++LL ++D VSLH L
Sbjct: 181 RIGQAVAKRALAFGMRVV-YHARTPKPLPYPF-----LSLEELLKEADVVSLHTPLTPET 234
Query: 245 HHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
H L+N + M+ GA L+NTARG LVD E L AL+ G + A LDV + EP
Sbjct: 235 HRLLNRERLFAMKRGAILINTARGALVDTEALVEALR-GHLFGAGLDVTDPEP 286
>UniRef50_Q87JV4 Cluster: D-lactate dehydrogenase; n=6; Vibrio|Rep:
D-lactate dehydrogenase - Vibrio parahaemolyticus
Length = 331
Score = 131 bits (316), Expect = 5e-29
Identities = 76/209 (36%), Positives = 116/209 (55%), Gaps = 9/209 (4%)
Query: 94 RIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVRE 153
++I +G D +D +AA ELG+ V VP Y E VA+ T+ L++ L RR + R+
Sbjct: 71 KLIAMRCAGFDKVDQQAAKELGLQVVRVPAYSPEAVAEHTVGLMMCLNRRLHKAYQRTRD 130
Query: 154 GKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIE 213
F+ E G G T+G++G G+IG A K G ++ YDPY + +
Sbjct: 131 AN-FS-----LEGLVGF-NFFGKTVGVIGTGKIGIATMRIFKGLGMELLCYDPY-ENPLA 182
Query: 214 KSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDD 273
+G R +L+++ +D +SLHC ++E N+HL+NE QM+ G ++NT+RG L+D
Sbjct: 183 LEMG-ARYCSLEEIYANADVISLHCPMSEENYHLLNENAFAQMKDGVMIINTSRGELLDS 241
Query: 274 EGLAAALKQGRIRAAALDVHENEPFNVFQ 302
ALKQG+I A LDV++NE FQ
Sbjct: 242 VAAIEALKQGKIGALGLDVYDNEKDLFFQ 270
>UniRef50_A6CRV0 Cluster: 2-hydroxyacid dehydrogenase; n=15;
Bacillales|Rep: 2-hydroxyacid dehydrogenase - Bacillus
sp. SG-1
Length = 351
Score = 131 bits (316), Expect = 5e-29
Identities = 87/239 (36%), Positives = 123/239 (51%), Gaps = 7/239 (2%)
Query: 62 EIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNV 121
EI + EA G L + + +E EK L+++ + G DNID+KAA E +AVCN
Sbjct: 64 EILLEKAGEASGILSMLSDPIDRELFEKSPNLKVVANLAVGFDNIDLKAANEKDVAVCNT 123
Query: 122 PGYGVEEVADTTMCLILNLYRRTYWLANMVREGK-KFTGPEQVREASAGCARIRGDTLGI 180
P + AD T L++ RR VREGK K P + AG I T+GI
Sbjct: 124 PDVLTDTTADLTFGLMMAAARRLIEADKYVREGKWKSWSPLLM----AG-TDIHHKTVGI 178
Query: 181 VGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSL 240
+G+G IG A A RAK F N+++++ E+ LG + +L++LL QSD V L
Sbjct: 179 IGMGSIGEAFARRAKGFDMNILYHNRSRKPEAEEVLG-AKYASLEELLSQSDYVVCLAPL 237
Query: 241 NEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFN 299
L+ + + M+ A +N ARG +V++E L AL G I AA LDV E EP +
Sbjct: 238 TPETKGLLQKEQFEMMKSSAIFINAARGPIVNEEALYRALVDGEIAAAGLDVFEKEPID 296
>UniRef50_A0Y9Y1 Cluster: Glyoxylate reductase; n=2; unclassified
Gammaproteobacteria|Rep: Glyoxylate reductase - marine
gamma proteobacterium HTCC2143
Length = 326
Score = 131 bits (316), Expect = 5e-29
Identities = 86/213 (40%), Positives = 118/213 (55%), Gaps = 7/213 (3%)
Query: 85 EDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRT 144
E + K L+ + + GVD++DV GI + + PG V+ AD L+L RR
Sbjct: 59 ELINSSKNLKAVSCVSVGVDHVDVGTLTARGIPLGHTPGVLVDATADLAFGLLLAAARRI 118
Query: 145 YWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFY 204
VR G + G +A GC+ + G TLGI+GLG IG A+A RA F VI +
Sbjct: 119 PQGDRHVRTGG-WQGASWSPKAFLGCS-VAGKTLGIIGLGDIGQALARRAAGFDMPVIAW 176
Query: 205 DPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVN 264
G E + G+ R +L+ +L QSD VS++ +L E LI+ + +M+PGA LVN
Sbjct: 177 SR---SGREVA-GV-RTLSLEQVLDQSDFVSINVALTEETRGLIDAAALSKMKPGAILVN 231
Query: 265 TARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
TARGG+VD+ LA ALK+GRI A DV E EP
Sbjct: 232 TARGGIVDERALAQALKEGRIAGAGFDVFEKEP 264
>UniRef50_P73821 Cluster: D-3-phosphoglycerate dehydrogenase; n=37;
Cyanobacteria|Rep: D-3-phosphoglycerate dehydrogenase -
Synechocystis sp. (strain PCC 6803)
Length = 554
Score = 131 bits (316), Expect = 5e-29
Identities = 91/258 (35%), Positives = 136/258 (52%), Gaps = 11/258 (4%)
Query: 41 VEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIG 100
V + ILK VA V S +EI + ++ E ++ +T++ ++ L+II R G
Sbjct: 41 VGIDILKQVAQVDVKTGLSEAEIID-IVPEYDAIMLRSATKVTEKIIQAGSQLKIIGRAG 99
Query: 101 SGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGP 160
GVDNIDV AA GI V N P A+ + +++ L R V+E K
Sbjct: 100 VGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDANKSVKESK----- 154
Query: 161 EQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTR 220
R+ G + TLG+VGLG+IGS VA AKA G ++ YDP++ +G T
Sbjct: 155 -WERKQFIG-TEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQIGCTL 212
Query: 221 VYTLQDLLF-QSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAA 279
V DLLF ++D ++LH +LIN T+ +M+P A ++N +RGG++D+E L A
Sbjct: 213 VDL--DLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEALVTA 270
Query: 280 LKQGRIRAAALDVHENEP 297
++ +I AALDV EP
Sbjct: 271 IETAQIGGAALDVFAQEP 288
>UniRef50_Q4L766 Cluster: D-3-phosphoglycerate dehydrogenase; n=3;
Staphylococcus|Rep: D-3-phosphoglycerate dehydrogenase -
Staphylococcus haemolyticus (strain JCSC1435)
Length = 532
Score = 130 bits (314), Expect = 8e-29
Identities = 75/231 (32%), Positives = 125/231 (54%), Gaps = 8/231 (3%)
Query: 67 VLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGV 126
++ + G ++ +T++ +EK L++I R G GVDNID+ AA GI V N P
Sbjct: 41 IIGDYEGLIVRSQTQVTQQVIEKASNLKVIARAGVGVDNIDIDAATLQGILVINAPDGNT 100
Query: 127 EEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRI 186
+ ++ +IL + R N+ + E R+A G + TLG++G GRI
Sbjct: 101 ISATEHSVAMILAMAR------NIPQAHASLKNKEWNRKAFKG-VELYQKTLGVIGAGRI 153
Query: 187 GSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHH 246
G VA R ++FG V+ YDPYL + + LG+ ++ T+ ++ Q+D V++H L
Sbjct: 154 GIGVAQRLQSFGMKVLAYDPYLTEDKAQQLGV-KLATIDEIARQADFVTVHTPLTPKTRG 212
Query: 247 LINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++N + +P ++N ARGG+++++ L AL +I AALDV E+EP
Sbjct: 213 IVNADFFSKAKPTLQIINVARGGIINEDDLLNALNNNQIARAALDVFEHEP 263
>UniRef50_Q9K1Q1 Cluster: Glycerate dehydrogenase; n=6; cellular
organisms|Rep: Glycerate dehydrogenase - Neisseria
meningitidis serogroup B
Length = 317
Score = 130 bits (313), Expect = 1e-28
Identities = 79/218 (36%), Positives = 110/218 (50%), Gaps = 6/218 (2%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L +I +GV+N+D+ AA G+AVCNV YG E VA+ L++ L R V
Sbjct: 66 LELIAVSATGVNNVDIGAAKAAGVAVCNVRAYGNESVAEHAFMLMIALMRNLPAYQRDVA 125
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
G P A + G TL + G G IG +A A+AFG V+F + +
Sbjct: 126 AGLWEKSPFFCHYG-APIRDLNGKTLAVFGRGNIGRTLAGYAQAFGMGVVFAEHKHASAV 184
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
+ + +D + +D +SLHC LN ++I E ++QM+PGA L+N RGGLVD
Sbjct: 185 REGY-----VSFEDAVRAADVLSLHCPLNAQTENMIGENELRQMKPGAVLINCGRGGLVD 239
Query: 273 DEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRP 310
+ L AALK G+I A +DV NEP LN P
Sbjct: 240 ENALLAALKYGQIGGAGVDVLTNEPPKNGNPLLNARLP 277
>UniRef50_A0UAW1 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=14; Burkholderiales|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Burkholderia multivorans ATCC 17616
Length = 452
Score = 130 bits (313), Expect = 1e-28
Identities = 84/205 (40%), Positives = 110/205 (53%), Gaps = 11/205 (5%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L++I + GSG+D ID AA GIAV G VA+ LIL + L +R
Sbjct: 209 LQVISKHGSGIDVIDQDAAAARGIAVRAAVGANAAAVAEHAWALILACAKSVPQLDMRMR 268
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
EG +A+ + G TLG+VGLG IG VA AFG V+ +DP+
Sbjct: 269 EG-------HWDKATHKSVELDGRTLGLVGLGAIGRRVAAIGVAFGMKVLAFDPFAK--- 318
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
E G+T V L L +SD VS+HC L N ++N T+ + + GA LVNTARGGL+D
Sbjct: 319 EAPAGVTLV-PLDTLYAESDVVSMHCPLTADNRRMLNRDTLARFKRGAILVNTARGGLID 377
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
+ LA AL G +RAAALD + EP
Sbjct: 378 EAALAEALTSGPLRAAALDSFDVEP 402
>UniRef50_Q5KFZ5 Cluster: Phosphoglycerate dehydrogenase, putative;
n=2; Filobasidiella neoformans|Rep: Phosphoglycerate
dehydrogenase, putative - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 339
Score = 130 bits (313), Expect = 1e-28
Identities = 82/238 (34%), Positives = 127/238 (53%), Gaps = 14/238 (5%)
Query: 68 LNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVE 127
L + + ++ T +T E + LRII R G+GVDN+ + GIAV N+PG
Sbjct: 54 LMKQIDGILLRTGDVTAEMVLAAPNLRIISRNGTGVDNVPLPTCLSRGIAVTNIPGSNAF 113
Query: 128 EVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIG 187
VA+ + L+L + RR +V K+ G E+V A + G +G+VG+G I
Sbjct: 114 AVAELAIALMLTVLRR------VVEVDKRIRGGERVPSIEALAPGLGGKKVGLVGMGDIA 167
Query: 188 SAVALRAKAFGFNVIFYDPYLPD---GIEKS-----LGLTRVYTLQDLLFQSDCVSLHCS 239
+A +AFG V+ + P P+ +E + + TR+ +L+ LL Q D +SLHC
Sbjct: 168 YELAKLLRAFGCEVLIHSPSSPELRWTVEDTRYPVTISHTRMPSLRSLLEQCDVLSLHCP 227
Query: 240 LNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
LN + ++I + M+ A ++NTARGG++D+ L ALK+ +I A LDV E EP
Sbjct: 228 LNANTRYMIGREELGWMKSTAVVINTARGGIIDERALEEALKERKIGGAGLDVFEKEP 285
>UniRef50_Q0FX01 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD binding subunit; n=3;
Rhodobacteraceae|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD binding subunit - Roseovarius sp.
HTCC2601
Length = 326
Score = 129 bits (312), Expect = 1e-28
Identities = 80/224 (35%), Positives = 122/224 (54%), Gaps = 10/224 (4%)
Query: 74 ALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTT 133
AL+ + +T E L + LR +++ G GVDNID+ A E G+ VCN P + VA+
Sbjct: 54 ALVVGLVPVTPETLTQGGKLRAVIKHGVGVDNIDIPACTEAGLPVCNTPAANADAVAELA 113
Query: 134 MCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALR 193
+ L+ ++ R W+ G R + ++ G TLGIVGLG IG +A
Sbjct: 114 VGLMFSMAR---WIPQ--GHASVTAGGWDRRIGT----QLGGKTLGIVGLGNIGKRLAKL 164
Query: 194 AKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTI 253
A+ G V+ D Y + G++ + L++LL QSD +SLH N LINE T+
Sbjct: 165 ARGLGMQVVATDKYPDEAFAAEHGISFL-PLEELLAQSDYISLHVFGGADNAALINEATL 223
Query: 254 KQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
Q++PGA L+N ARG +VD + +A AL+ G++ A+D + +EP
Sbjct: 224 AQIKPGAKLINLARGEVVDLDAVAKALESGQLGGVAIDAYVSEP 267
>UniRef50_A0V9Y4 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=2; Comamonadaceae|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Delftia acidovorans SPH-1
Length = 354
Score = 129 bits (311), Expect = 2e-28
Identities = 82/241 (34%), Positives = 123/241 (51%), Gaps = 12/241 (4%)
Query: 61 SEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCN 120
+E+ + E+V A++ T L+ + L++I + G GV NIDV AA + GI V
Sbjct: 63 AEVAAVLARESVDAVISRTATLSAAAIAACPTLKVISKHGVGVSNIDVAAASQRGIPVYV 122
Query: 121 VPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGI 180
PG + VA+ T+ L+ RR W+ +R G+ + + + G TLG+
Sbjct: 123 TPGANAQSVAEMTLGLMFAAARRIAWMDAELRAGRWSRAQDGLE--------LSGRTLGL 174
Query: 181 VGLGRIGSAVALRAKAFGFNVIFYDPYLPD----GIEKSLGLTRVYTLQDLLFQSDCVSL 236
+G G++G VA A A G V+ +DP G G+ + ++ +LL SD +SL
Sbjct: 175 LGFGQVGQRVARVALALGMQVVAFDPAFDPACAPGPGAVAGVRMLGSVDELLPLSDVLSL 234
Query: 237 HCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
H LN HL++ I Q+ GA LVNTARG +VD+ L AL+ G + AA LD E
Sbjct: 235 HLPLNARTRHLLDAGRIAQLPRGALLVNTARGEVVDEAALIDALRSGHLAAAGLDTMAEE 294
Query: 297 P 297
P
Sbjct: 295 P 295
>UniRef50_Q9K7P7 Cluster: Glycerate dehydrogenase; n=8;
Bacillaceae|Rep: Glycerate dehydrogenase - Bacillus
halodurans
Length = 324
Score = 128 bits (310), Expect = 2e-28
Identities = 86/239 (35%), Positives = 125/239 (52%), Gaps = 7/239 (2%)
Query: 62 EIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNV 121
E+ K L EA G T E E+ K L+++ + G DNID+K A + G++V +
Sbjct: 36 ELFLKELEEADGVFTNLTDRFDVEAFERAKRLKVVSTMAVGYDNIDIKEATKRGVSVGHT 95
Query: 122 PGYGVEEVADTTMCLILNLYRRTYWLANMVREGK-KFTGPEQVREASAGCARIRGDTLGI 180
PG E AD T L++ RR + VR + K GP + G A I G TLGI
Sbjct: 96 PGVLTEATADLTFALLMATGRRLRESIDYVRNDQWKSWGPFML----TGQA-IYGTTLGI 150
Query: 181 VGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSL 240
+G+GRIG AVA RAK F +++++ + EK LG T +L LL +SD V L
Sbjct: 151 IGMGRIGQAVAKRAKGFNMTLLYHNRSRNEQAEKELGATYC-SLDHLLARSDYVVLLAPS 209
Query: 241 NEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFN 299
+ ++ ++M+ A +NT+RG VD++ L AL +G I A LDV+E EP +
Sbjct: 210 TDETRKMMGPAQFQKMKSTAHFINTSRGTNVDEQALYRALTEGWIAGAGLDVYEKEPIS 268
>UniRef50_Q7WNI7 Cluster: Putative dehydrogenase; n=1; Bordetella
bronchiseptica|Rep: Putative dehydrogenase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 333
Score = 128 bits (310), Expect = 2e-28
Identities = 83/218 (38%), Positives = 116/218 (53%), Gaps = 8/218 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
LT LE +R + + G GVD IDV AA LGI + G VA+ + LIL +Y
Sbjct: 61 LTAGMLEAATRVRAVHKWGIGVDRIDVDAARRLGIPLAITAGSNAGPVAELAVALILGVY 120
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
RR ++ +R G+ ++RE+ C +I T+G+VG G IG +A R F +
Sbjct: 121 RRLCYVNREMRAGQ--WPKAEMRES---CFQIHRKTIGLVGFGNIGRKLARRLSGFEPDA 175
Query: 202 IFY--DPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPG 259
I Y P +E++LG RV L +LL SD VSLH LI+ ++ M+ G
Sbjct: 176 ILYCDQQAAPAEVERALGARRV-ELPELLAASDIVSLHLPCTASTRRLIDAAALQHMKKG 234
Query: 260 AFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
A L+NTARG LVD+ LA AL++G + A LD + EP
Sbjct: 235 AVLINTARGELVDEAALAEALQRGHLLGAGLDAFDPEP 272
>UniRef50_A6ULR7 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase NAD-binding; n=1; Sinorhizobium medicae
WSM419|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase NAD-binding - Sinorhizobium medicae WSM419
Length = 328
Score = 128 bits (310), Expect = 2e-28
Identities = 81/255 (31%), Positives = 130/255 (50%), Gaps = 10/255 (3%)
Query: 52 VAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAA 111
V+F + +E+ E + + A++ T+ L +E ALR+I R G G +N+D+++A
Sbjct: 27 VSFLKEGTEAELAESLRSTPFDAVISRTLALPAMMIETAPALRVISRHGVGYNNVDIESA 86
Query: 112 GELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCA 171
G+ V G + VA+ + L L++ R+ +R Q ++ G
Sbjct: 87 TRRGVPVLIADGANGKSVAELAVGLALSVARKITTQDASIRA-------RQWNRSAYGL- 138
Query: 172 RIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQS 231
+ G T GIV G IG VA +A +I +DP+ D + G+ TL +LL +S
Sbjct: 139 QFAGKTAGIVAFGAIGRRVAEILRAMDMRIIAFDPHARD--RSTTGVDWTETLDELLQES 196
Query: 232 DCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALD 291
D VSLHC L ++I + +M+PGA L+NTARGGL+D++ LA A+ G + A LD
Sbjct: 197 DLVSLHCPLTPETRNMITAPRLARMKPGAILINTARGGLIDEKALAEAVLSGHLAGAGLD 256
Query: 292 VHENEPFNVFQAYLN 306
+EP +L+
Sbjct: 257 TFADEPLPADHPFLS 271
>UniRef50_A0L0H4 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=13; Bacteria|Rep: D-isomer
specific 2-hydroxyacid dehydrogenase, NAD-binding -
Shewanella sp. (strain ANA-3)
Length = 329
Score = 128 bits (310), Expect = 2e-28
Identities = 76/203 (37%), Positives = 114/203 (56%), Gaps = 9/203 (4%)
Query: 94 RIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVRE 153
+II +G +N+D+ AA LG+ V NVP Y E VA+ T+ L+L L R+ + R+
Sbjct: 70 KIIAMRCAGFNNVDLVAAKRLGMQVVNVPAYSPESVAEHTVALMLTLNRKIHKAYQRTRD 129
Query: 154 GKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIE 213
F+ E G + G T+G++G G+IG A FG VI +DPY P+
Sbjct: 130 AN-FS-----LEGLVGF-NMFGKTVGVIGTGKIGVATIKVLLGFGCKVIAFDPY-PNPAV 181
Query: 214 KSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDD 273
++L + L + SD +SLHC L NHHL+N+ + +M+PG ++NT+RGGL++
Sbjct: 182 EALNV-EYQDLDTIYANSDIISLHCPLTADNHHLLNKESFAKMKPGVMVINTSRGGLLNA 240
Query: 274 EGLAAALKQGRIRAAALDVHENE 296
ALK G+I + LDV+ENE
Sbjct: 241 FDAMEALKLGQIGSLGLDVYENE 263
>UniRef50_A2R1X3 Cluster: Remark: D(--)-Mandelate dehydrogenase;
n=1; Aspergillus niger|Rep: Remark: D(--)-Mandelate
dehydrogenase - Aspergillus niger
Length = 359
Score = 128 bits (310), Expect = 2e-28
Identities = 78/208 (37%), Positives = 113/208 (54%), Gaps = 2/208 (0%)
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
+++I G+G ++I V + GI N G E VADTT+ +IL+++R
Sbjct: 81 SVKIFASAGAGYNDISVPSLTARGIYYTNGAGASDEAVADTTLYMILSVFRNFTASQIAA 140
Query: 152 REGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKA-FGFNVIFYDPY-LP 209
R G E R + RG LG++GLGRIGS V + + G V++YD L
Sbjct: 141 RSGDTERFLECHRNLAGVSTNPRGKVLGLIGLGRIGSEVVRKVRGGLGMEVVYYDAVRLS 200
Query: 210 DGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGG 269
+ E+ LG+ ++ +L +DCVS+HC L E LI++ I MR G +VN ARGG
Sbjct: 201 EERERELGVRWGGGIRGVLEGADCVSVHCPLTEGTRGLIDKEKIGWMRDGVRVVNVARGG 260
Query: 270 LVDDEGLAAALKQGRIRAAALDVHENEP 297
+V +E L L+ G++ AAALDVHE EP
Sbjct: 261 VVVEEDLVQGLRSGKVAAAALDVHEFEP 288
>UniRef50_Q7W397 Cluster: Putative 2-hydroxyacid dehydrogenase; n=4;
Bordetella|Rep: Putative 2-hydroxyacid dehydrogenase -
Bordetella parapertussis
Length = 322
Score = 128 bits (309), Expect = 3e-28
Identities = 80/215 (37%), Positives = 114/215 (53%), Gaps = 12/215 (5%)
Query: 85 EDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCL--ILNLYR 142
E ++ ALR++V G + ID++A GI VC PG A + IL L++
Sbjct: 63 ELIQALPALRLLVTTGMRNNAIDMQACAAGGILVCGAPGSAEAGAATAELAWAHILALFK 122
Query: 143 RTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVI 202
R +R G TG Q + G LG++GLG++GSAVA +AFG V+
Sbjct: 123 RLPQEDAAMRRGLWQTGMPQP---------LAGRRLGVLGLGKLGSAVAQVGRAFGMEVV 173
Query: 203 FYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFL 262
+ P L D G+TRV L +D VSLH L E H+++ + M+P A+L
Sbjct: 174 AWSPNLTDERAAQAGVTRV-DKHTLFSTADVVSLHLILGESTRHIVDAAALSAMKPSAYL 232
Query: 263 VNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
VNT+R GLVD + L AL++GR+ A LDV+E+EP
Sbjct: 233 VNTSRAGLVDQDALLDALRKGRLAGAGLDVYESEP 267
>UniRef50_A7HBU0 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase NAD-binding; n=2; Anaeromyxobacter|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase
NAD-binding - Anaeromyxobacter sp. Fw109-5
Length = 313
Score = 128 bits (309), Expect = 3e-28
Identities = 87/244 (35%), Positives = 127/244 (52%), Gaps = 13/244 (5%)
Query: 65 EKVLNEAVGALMWHTIILTKED---LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNV 121
E+++ EA A + + + D ++ ALR + G GV+++D+ A G+ V N
Sbjct: 36 ERLVEEAREAAVLVPTYIDRVDAALVDALPALRHVASYGVGVNHLDLDACRRRGVLVTNT 95
Query: 122 PGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIV 181
PG + AD M L+L RR +VR G G +V A + G T+G+V
Sbjct: 96 PGVVTDATADHAMALLLAAARRVVEGDRVVRAG----GWTEVDPAWMLGTEVTGKTVGVV 151
Query: 182 GLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLN 241
G GRIG A A RA+ F V++ P + + L+ LL ++D VSLH L
Sbjct: 152 GFGRIGQAFARRARGFDTRVLYTSPR-----DAGVAWAERVGLERLLAEADFVSLHVPLV 206
Query: 242 EHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVF 301
+L++ + ++PGA +VNTARGG++DD LA AL GRI AA LDV +EP V
Sbjct: 207 PATRNLLSRERLALLKPGAIVVNTARGGVLDDAALAEALADGRIGAAGLDVFPDEP-RVP 265
Query: 302 QAYL 305
+AYL
Sbjct: 266 EAYL 269
>UniRef50_A1UEI9 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=5; Mycobacterium|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Mycobacterium sp. (strain KMS)
Length = 321
Score = 128 bits (309), Expect = 3e-28
Identities = 83/206 (40%), Positives = 106/206 (51%), Gaps = 8/206 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
LR++ + G DNIDV AA G+ V N PG AD T LIL + RR +R
Sbjct: 72 LRVVANVAVGYDNIDVAAAHAAGVTVTNTPGVLDNATADHTFALILAVTRRVVDGDRFLR 131
Query: 153 EGKKFT-GPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDG 211
+ + GP + G G TLGI+G GRIG AVA RA+AF V+ G
Sbjct: 132 SRRPWIWGPRML----TGLDVSAGATLGILGYGRIGRAVARRARAFDMTVLATSRRRTSG 187
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
+ + TL L SD V + L HLI+ + +M+ A+LVNTARGG+V
Sbjct: 188 ADDDVWFVDTDTL---LADSDVVCVLTPLTPETRHLIDAAALDRMKSTAYLVNTARGGVV 244
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
D+ L AL+ GRI AALDV ENEP
Sbjct: 245 DESALIDALRAGRIGGAALDVFENEP 270
>UniRef50_Q8UJZ6 Cluster: Phosphoglycerate dehydrogenase; n=3;
Alphaproteobacteria|Rep: Phosphoglycerate dehydrogenase
- Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Length = 354
Score = 128 bits (308), Expect = 4e-28
Identities = 71/206 (34%), Positives = 110/206 (53%), Gaps = 7/206 (3%)
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
+LR++ + G GVDNIDV AA I V G VA+ + L+ + +R L + +
Sbjct: 93 SLRVLSKHGVGVDNIDVDAASRREIPVVVAAGANALSVAEHAITLLFAVVKRIVPLDSGI 152
Query: 152 REGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDG 211
R G+ +A + G +G+VG G I A+ A+ FG V YDP+ +
Sbjct: 153 RAGRW-------EKAGYSGKELAGMIIGLVGFGAIARQTAVFARGFGLKVQAYDPFTDET 205
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
G+ RV + DL+ SD +SLHC L +L+++ + M+PG+F++NTARGGL+
Sbjct: 206 AFVEAGVHRVADVDDLISSSDILSLHCPLTPDTRNLLDDRRLGMMKPGSFIINTARGGLI 265
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
D++ L A++ G I A LD + EP
Sbjct: 266 DEDALLRAVESGHIAGAGLDTFQIEP 291
>UniRef50_A5ZQ76 Cluster: Putative uncharacterized protein; n=2;
Clostridiales|Rep: Putative uncharacterized protein -
Ruminococcus obeum ATCC 29174
Length = 339
Score = 128 bits (308), Expect = 4e-28
Identities = 80/214 (37%), Positives = 116/214 (54%), Gaps = 12/214 (5%)
Query: 89 KFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLA 148
+ + +R+I+ +G +N+D+ E GI V VPGY E VA+ M L+L R T+
Sbjct: 77 RHQGIRLILMRCAGYNNVDLNKTAECGIKVLRVPGYSPEAVAEHAMALVLTANRHTHKAY 136
Query: 149 NMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYL 208
RE F+ G + G T GIVG G+IG A+A + FG ++ YD Y
Sbjct: 137 IKCRENN-FS-----LNGLMG-VNLYGKTAGIVGTGKIGLAMARICQGFGMKIVAYDLY- 188
Query: 209 PDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARG 268
P+ +S GL V +L LL SD +SLHC L HH+IN+ +I +M+ G LVNT+RG
Sbjct: 189 PN---ESSGLEYV-SLDRLLAISDLISLHCPLTPETHHMINKKSISRMKDGVILVNTSRG 244
Query: 269 GLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQ 302
GL+ E L ++ + A LDV+E E V++
Sbjct: 245 GLICTEDLITGIRDHKFWAVGLDVYEEESDFVYE 278
>UniRef50_Q7WEA3 Cluster: Phosphoglycerate dehydrogenase; n=1;
Bordetella bronchiseptica|Rep: Phosphoglycerate
dehydrogenase - Bordetella bronchiseptica (Alcaligenes
bronchisepticus)
Length = 329
Score = 127 bits (307), Expect = 6e-28
Identities = 80/217 (36%), Positives = 112/217 (51%), Gaps = 7/217 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
L E ++ L +I G+G D I V A LGI V P V VA+ + L+L
Sbjct: 52 LPAELIDMAPRLCVIANHGTGTDKIAVAHADALGIPVVYTPQANVRSVAEHALMLMLVTA 111
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA-LRAKAFGFN 200
R+ R+G EQ + + G TLG++GLGR G + + A A
Sbjct: 112 RQAVQADAATRKGHWGFKYEQPMYS------LYGKTLGVIGLGRTGRLLCEMAAPALNMQ 165
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
+ + P LP G G RV TLQ+LL ++D VSLH L H ++ T+ M+PGA
Sbjct: 166 ALVWSPSLPAGEALPPGARRVDTLQELLREADVVSLHRPLRPDTRHTLDAATLACMKPGA 225
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++NT+RGGL+D+ LA AL++GR+ A LDV E EP
Sbjct: 226 IVINTSRGGLIDEAALADALREGRLAGAGLDVFETEP 262
>UniRef50_Q2RTD0 Cluster: Glycolate reductase; n=8;
Alphaproteobacteria|Rep: Glycolate reductase -
Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Length = 323
Score = 127 bits (307), Expect = 6e-28
Identities = 80/206 (38%), Positives = 109/206 (52%), Gaps = 5/206 (2%)
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
++ II G ++ID AA GI V N PG + AD + L+L RR +V
Sbjct: 72 SVAIIASFSVGYEHIDHNAAARRGILVTNTPGVLSDATADIALLLMLGAARRASEGERLV 131
Query: 152 REGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDG 211
R G + G V+ + G LGI+G+GRIG A+A RA+ G I Y P
Sbjct: 132 RSGY-WKGLTPVQLLGR---HLHGQRLGILGMGRIGQALAERARPLGLE-IHYHNRTPIA 186
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
+ + G T++DLL SD +SLHC L+N + + PGA +VNTARG L+
Sbjct: 187 EDAAKGAIFHATVEDLLAVSDVLSLHCPATPLTRKLLNAERLALLPPGAIVVNTARGILI 246
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
DDE L AAL G++ AA LDV++NEP
Sbjct: 247 DDEALIAALNSGQVFAAGLDVYDNEP 272
>UniRef50_A1HQU2 Cluster: Glyoxylate reductase; n=1; Thermosinus
carboxydivorans Nor1|Rep: Glyoxylate reductase -
Thermosinus carboxydivorans Nor1
Length = 324
Score = 127 bits (307), Expect = 6e-28
Identities = 86/230 (37%), Positives = 120/230 (52%), Gaps = 7/230 (3%)
Query: 68 LNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVE 127
L +A G + + + E L LR+I + G DN+D+ A GI N PG VE
Sbjct: 44 LADAEGLVSTGDVRVDDELLAHAPRLRVIAQASVGYDNVDIAACTRRGIPFGNTPGVLVE 103
Query: 128 EVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIG 187
AD T L+L RR + N V G+ + G + G TLGIVG+GRIG
Sbjct: 104 ATADLTFGLLLCAARRIHEGWNQVASGRWLNN----HDVPFGID-LYGKTLGIVGMGRIG 158
Query: 188 SAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHL 247
+AVA RAKA G VI+++ ++ LG T V DLL Q+DC+ + L+ + +
Sbjct: 159 AAVARRAKACGMKVIYHNRSRRTD-DEHLGATYV-AFDDLLAQADCIVVLVPLSPASQGM 216
Query: 248 INEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+M+ A+ +N ARGGLVD + L ALK+G+I AALDV + EP
Sbjct: 217 FGRAEFAKMKRTAYFINAARGGLVDTQALYDALKEGQIAYAALDVTDPEP 266
>UniRef50_UPI0000DB72A4 Cluster: PREDICTED: similar to
3-phosphoglycerate dehydrogenase; n=1; Apis
mellifera|Rep: PREDICTED: similar to 3-phosphoglycerate
dehydrogenase - Apis mellifera
Length = 478
Score = 127 bits (306), Expect = 7e-28
Identities = 73/205 (35%), Positives = 111/205 (54%), Gaps = 8/205 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
LR++ R G+GVDNID++AA G+ V N PG + T LI NL R ++
Sbjct: 69 LRVVGRAGTGVDNIDLEAATRKGVIVLNTPGGNSISACELTCALISNLARNVTQAVQSLK 128
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
+G+ R+ +G + G TL ++G+GRIG V R +A+G VI +DP L
Sbjct: 129 DGR------WDRKLYSGF-ELSGKTLAVLGMGRIGREVTRRMQAYGMRVIAFDPLLTSED 181
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
L + + ++L ++ +D +++H L +LIN T+ + + G ++N ARGG+VD
Sbjct: 182 ANYLNVEK-FSLDEIWPMADYITVHTPLIPQTKNLINATTLAKCKKGVRIINVARGGIVD 240
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
+E L ALK G AALDV EP
Sbjct: 241 EEALLNALKSGHCAGAALDVFTEEP 265
>UniRef50_Q98LH4 Cluster: Phosphoglycerate dehydrogenase; n=3;
Mesorhizobium loti|Rep: Phosphoglycerate dehydrogenase -
Rhizobium loti (Mesorhizobium loti)
Length = 341
Score = 127 bits (306), Expect = 7e-28
Identities = 82/221 (37%), Positives = 121/221 (54%), Gaps = 20/221 (9%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPG-YGVEEVADTTMCLILNL 140
+T+ ++ LR I + G GVD+ID+ AA E GI V + P + + V++ + L+L +
Sbjct: 69 ITRRVMQALPDLRYISKYGIGVDSIDIDAATEHGILVSSTPNDFQIFTVSEHAVALMLAV 128
Query: 141 YRRT-YWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGF 199
++ W +R G R + G A +RG T+GIVGLGRIG VA R +
Sbjct: 129 AKQLGTWTPEFMRRGGW-------RGLTHG-ATLRGATVGIVGLGRIGRGVAQRLSGWEA 180
Query: 200 NVIFYDPYL---PDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQM 256
++ YDP+L P GIE + L+ QSD ++LH + + NHH++N +M
Sbjct: 181 RILAYDPFLKEAPPGIE-------LVDFPTLVEQSDFLTLHATPSPDNHHILNAAAFAKM 233
Query: 257 RPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+P A +VNT RG L+D L AAL G+I AALDV + EP
Sbjct: 234 KPSAIVVNTGRGSLIDYTALRAALANGQIAGAALDVFDQEP 274
>UniRef50_Q896Z8 Cluster: 2-hydroxyacid dehydrogenase; n=4;
Clostridium|Rep: 2-hydroxyacid dehydrogenase -
Clostridium tetani
Length = 357
Score = 127 bits (306), Expect = 7e-28
Identities = 84/228 (36%), Positives = 118/228 (51%), Gaps = 10/228 (4%)
Query: 70 EAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEV 129
E L+ + L KE +E L++I +G+D+I+++ + I VCN GY V
Sbjct: 88 ETADVLILANMPLKKEVIEAATNLKMISVAFTGIDHINMETCRKNNIMVCNSAGYSTSSV 147
Query: 130 ADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSA 189
+ T LIL+L R L + VR G G Q A G TLG++G G IG+
Sbjct: 148 VELTFGLILSLLRNIVPLNDEVRNGNTKQGYSQYDLA--------GKTLGVIGAGDIGTE 199
Query: 190 VALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLIN 249
V KAFG NV+ Y+ I K LG T+ TL ++L SD V+LH N LIN
Sbjct: 200 VIRIGKAFGCNVLVYNRSEKQHI-KELGATQT-TLDEVLKNSDIVTLHIPSNNETKGLIN 257
Query: 250 EFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ M+ A L+NTARG +VD++ LA AL +G + A +DV + EP
Sbjct: 258 SEKLAMMKKDALLINTARGPVVDNKALAEALNKGELGGAGIDVFDMEP 305
>UniRef50_Q3DL54 Cluster: Glyoxylate reductase, NADH-dependent; n=9;
Streptococcus|Rep: Glyoxylate reductase, NADH-dependent
- Streptococcus agalactiae 515
Length = 318
Score = 127 bits (306), Expect = 7e-28
Identities = 80/215 (37%), Positives = 115/215 (53%), Gaps = 6/215 (2%)
Query: 84 KEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRR 143
KE ++ + L+II G D++D A E GI V N P A+ T LIL +R
Sbjct: 58 KEMIDAGENLQIISLNAVGFDHVDTAYAKEKGIIVSNSPQAVRVPTAEMTFALILAASKR 117
Query: 144 TYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIF 203
+ ++VR G+ EQ + ++G TLGI G+GRIG VA AKAFG V++
Sbjct: 118 LAFYDSIVRSGEWIDPSEQRYQGLT----LQGSTLGIYGMGRIGLTVANFAKAFGMTVVY 173
Query: 204 YDPY-LPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFL 262
D Y LP+ EK LG+T + L+ +D +++H H N+ +M+ ++L
Sbjct: 174 NDVYRLPEDKEKELGVTYL-EFDQLIKTADVITIHAPALPSTIHKFNKDVFAKMKNRSYL 232
Query: 263 VNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+N ARG +V +E L ALK+G I A LDV ENEP
Sbjct: 233 INAARGPIVSEEALIEALKEGEIAGAGLDVFENEP 267
>UniRef50_Q3CIY1 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, catalytic region:D- isomer specific
2-hydroxyacid dehydrogenase, NAD-binding; n=2;
Thermoanaerobacter ethanolicus|Rep: D-isomer specific
2-hydroxyacid dehydrogenase, catalytic region:D- isomer
specific 2-hydroxyacid dehydrogenase, NAD-binding -
Thermoanaerobacter ethanolicus ATCC 33223
Length = 319
Score = 127 bits (306), Expect = 7e-28
Identities = 78/211 (36%), Positives = 119/211 (56%), Gaps = 11/211 (5%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
++K K L+II + G GVD+IDVK A +LGI V N PG EEVAD L L++ R +
Sbjct: 67 IKKCKRLKIIAKHGVGVDSIDVKTANQLGIVVTNAPGTNSEEVADLAFGL-LHMLARGLY 125
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
AN + K+ P + + T+GI+G+G IG+AVA RA + N++ YD
Sbjct: 126 QANTDTKNGKWIKPVGI--------SLSKKTIGIIGVGTIGTAVAKRATGYDMNILGYD- 176
Query: 207 YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
+ + LG+ V L +LL ++D +SLH L +++N K ++ GA ++NTA
Sbjct: 177 IKKNPLALGLGVKYV-GLDELLSEADFISLHLPLTNDTLNILNADKFKLIKKGAIMINTA 235
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
R L+D+E L +L G ++ A DV++ EP
Sbjct: 236 RSQLIDNEALYNSLIDGTLKGYATDVYDFEP 266
>UniRef50_Q9HVG5 Cluster: Glycerate dehydrogenase; n=23;
Gammaproteobacteria|Rep: Glycerate dehydrogenase -
Pseudomonas aeruginosa
Length = 323
Score = 126 bits (305), Expect = 1e-27
Identities = 81/205 (39%), Positives = 110/205 (53%), Gaps = 7/205 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L +I+ +G +NID+ AA E GI V N GYG VA T+ L+L L R VR
Sbjct: 71 LELILISATGTNNIDLAAARERGIVVANCHGYGTPSVAQHTLALLLALATRLPDYQQAVR 130
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
G+ + Q + G TLG++G G +G AVA A+AFG V+ LP
Sbjct: 131 SGR-WQQSSQFCLLDFPIVELEGKTLGLLGHGELGGAVARLAEAFGMRVLLGQ--LPGRP 187
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
++ L L +LL + D ++LHC L E ++ + M+PGAFLVNTARGGLVD
Sbjct: 188 ARADRLP----LGELLPRVDALTLHCPLTEDTRGMLGSAELALMKPGAFLVNTARGGLVD 243
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
++ LA AL+ G + AA DV EP
Sbjct: 244 EQALADALRGGHLGGAATDVLSVEP 268
>UniRef50_Q49ZM5 Cluster: Putative dehydrogenase; n=1;
Staphylococcus saprophyticus subsp. saprophyticus ATCC
15305|Rep: Putative dehydrogenase - Staphylococcus
saprophyticus subsp. saprophyticus (strain ATCC 15305
/DSM 20229)
Length = 318
Score = 126 bits (305), Expect = 1e-27
Identities = 77/217 (35%), Positives = 116/217 (53%), Gaps = 11/217 (5%)
Query: 84 KEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRR 143
KE ++ L+II G+G +N+D+ A + I V N P A+ T L+L + RR
Sbjct: 59 KEVIDAANNLKIITNYGAGFNNVDIDYARQQNIDVTNTPKASTNSTAELTFALVLAVARR 118
Query: 144 TYWLANMVREGKKF---TGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
+ EG K TG + + G T+GI+GLG IGSAVA RAKAF N
Sbjct: 119 -------IPEGDKLCRTTGFDGWAPLFFRGREVSGKTIGIIGLGEIGSAVARRAKAFDMN 171
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
+++ P+ E+ +G V L+ LL +D V+++ + N HH I++ + M+P +
Sbjct: 172 ILYTGPHQKVDKEREIGAKYV-DLETLLKNADFVTINAAYNPSLHHQIDKAQFEMMKPTS 230
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+L+N +RG +V ++ L ALK I AALDV E EP
Sbjct: 231 YLINASRGPIVHEKALVQALKDKEIEGAALDVFEFEP 267
>UniRef50_A1FGW0 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Pseudomonas putida
W619|Rep: D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Pseudomonas putida W619
Length = 318
Score = 126 bits (305), Expect = 1e-27
Identities = 86/224 (38%), Positives = 115/224 (51%), Gaps = 6/224 (2%)
Query: 75 LMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTM 134
L+ T+ L E L+ +L++I + +G DN + + GI + N P E ADT
Sbjct: 48 LIGSTLPLDAELLDHAPSLKVIASVSAGFDNYPLGYLRDRGICLTNTPDAVTETTADTGF 107
Query: 135 CLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRA 194
L++ RR LA +VR+G G Q +AS + G TLGIVGLGRIG+AVA RA
Sbjct: 108 MLLMMAARRACELAQLVRDG----GWTQGIDASRFGMDVHGKTLGIVGLGRIGAAVARRA 163
Query: 195 K-AFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTI 253
FG V++ E RV +Q LL ++D V + L+ HHL
Sbjct: 164 HFGFGMPVLYSGNSAKPEYEAEFAARRVPLMQ-LLGEADFVCVCVPLSAATHHLFGRAQF 222
Query: 254 KQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
MR A VN ARG +VD+ L AL +G+IRAA LDV E EP
Sbjct: 223 AAMRADAVFVNIARGAVVDERALLKALAEGQIRAAGLDVFELEP 266
>UniRef50_Q0W672 Cluster: Glycerate dehydrogenase; n=2; Archaea|Rep:
Glycerate dehydrogenase - Uncultured methanogenic
archaeon RC-I
Length = 319
Score = 126 bits (305), Expect = 1e-27
Identities = 76/205 (37%), Positives = 111/205 (54%), Gaps = 10/205 (4%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L+++ +G D++D+ AA G+AV N PGY E VA+ ++L+ RR +R
Sbjct: 66 LKLVALTRTGYDDVDLDAATLKGVAVANAPGYSNEAVAEHVFAMLLSFIRRISEADFWIR 125
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
E K + RE +RG T+GI+G G+IG VA A+ FG +VI YD +
Sbjct: 126 EEKFDCTAFEGRE-------LRGKTMGIIGTGQIGLRVAEIARCFGMDVIAYDVRRNPAV 178
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
+ L R L L +SD +++H L LI+E + + M+PGA ++NTARG +VD
Sbjct: 179 AEKL---RYVGLDRLCAESDFITVHLPLTSDTRGLIDEESFRLMKPGAVIINTARGPVVD 235
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
L AL +GRI A LDV + EP
Sbjct: 236 QAALLRALDEGRIAGACLDVFDQEP 260
>UniRef50_Q82W00 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase; n=7; Bacteria|Rep: D-isomer specific
2-hydroxyacid dehydrogenase - Nitrosomonas europaea
Length = 330
Score = 126 bits (304), Expect = 1e-27
Identities = 86/273 (31%), Positives = 131/273 (47%), Gaps = 27/273 (9%)
Query: 101 SGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGP 160
+G +N+D+KAA I V VP Y VA+ T+ +I+ L R+T+ N VRE + F+
Sbjct: 77 AGFNNVDIKAAHACNIRVVRVPAYSPHAVAEHTLAMIMTLNRKTHKAYNRVRE-QNFS-- 133
Query: 161 EQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTR 220
G + T+G++G G IG G N++ DP IEK +G+
Sbjct: 134 ---LNGLLGFD-LHKKTVGVIGTGHIGEVFCRIMHGLGCNILACDPVKKLEIEK-MGIPY 188
Query: 221 VYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAAL 280
V + +L + D +SLHC LNE +LI+ I QM+ G L+NT RGGL+D + + A L
Sbjct: 189 V-PMNELFSRCDILSLHCPLNEETRYLIDSSVIAQMKTGVMLINTGRGGLIDTKAVIAGL 247
Query: 281 KQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQ--GPLKDAPNLL 338
K G+I +DV+E E FQ ++L L PN+L
Sbjct: 248 KSGKIGYLGIDVYEQEADLFFQNLSE----------------QIILDDTIARLMTFPNVL 291
Query: 339 CTPHAAFYSDASAQELREMAASEIRRAIVGRIP 371
T H F++ + ++ + I+R + G IP
Sbjct: 292 ITAHQGFFTQEALDQIALTTFANIKRFVAGEIP 324
>UniRef50_Q6RK69 Cluster: D-lactate dehydrogenase; n=1;
Lactobacillus sp. MD-1|Rep: D-lactate dehydrogenase -
Lactobacillus sp. MD-1
Length = 331
Score = 126 bits (304), Expect = 1e-27
Identities = 84/270 (31%), Positives = 129/270 (47%), Gaps = 21/270 (7%)
Query: 102 GVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPE 161
G DNID++AA + + NVP Y E +A+ + + L L R+ ++ ++E +F
Sbjct: 78 GTDNIDIQAAKANNVKITNVPAYSPESIAEFAVMMALYLSRKVGYMQQQLQEQHEF---- 133
Query: 162 QVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRV 221
A G I T+G++G GRIG + G NVI YD Y P I V
Sbjct: 134 HFSPAFMG-RLISEQTVGVIGTGRIGRHAIQLFRGLGANVIAYDKY-PQKITGG-AFKYV 190
Query: 222 YTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALK 281
L+D++ QSD +SLH N HL N ++M+P A L+NTARG +VD L AL+
Sbjct: 191 DHLEDIIKQSDIISLHMPATADNFHLFNHEVFEEMKPNAILINTARGTIVDTNDLIFALE 250
Query: 282 QGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCTP 341
G I AA +D E+E + L R S++ PN++ TP
Sbjct: 251 SGEIAAAGIDTLEDESID-----LQDSRSTKKITDADLIKLSMM---------PNVILTP 296
Query: 342 HAAFYSDASAQELREMAASEIRRAIVGRIP 371
H+AF++ S + + ++ + ++ G P
Sbjct: 297 HSAFHTTESVKNMVNISLNNLKTMAEGGKP 326
>UniRef50_O43175 Cluster: D-3-phosphoglycerate dehydrogenase; n=53;
Bilateria|Rep: D-3-phosphoglycerate dehydrogenase - Homo
sapiens (Human)
Length = 533
Score = 126 bits (304), Expect = 1e-27
Identities = 80/234 (34%), Positives = 122/234 (52%), Gaps = 16/234 (6%)
Query: 68 LNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVE 127
L + G ++ +T + + + L+++ R G+GVDN+D++AA GI V N P
Sbjct: 45 LQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSL 104
Query: 128 EVADTT----MCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGL 183
A+ T MCL + + T + + E KKF G E + G TLGI+GL
Sbjct: 105 SAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTE-----------LNGKTLGILGL 153
Query: 184 GRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEH 243
GRIG VA R ++FG I YDP + + S G+ ++ L+++ D +++H L
Sbjct: 154 GRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQL-PLEEIWPLCDFITVHTPLLPS 212
Query: 244 NHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L+N+ T Q + G +VN ARGG+VD+ L AL+ G+ AALDV EP
Sbjct: 213 TTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEP 266
>UniRef50_A5ZA39 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 381
Score = 126 bits (303), Expect = 2e-27
Identities = 81/245 (33%), Positives = 133/245 (54%), Gaps = 9/245 (3%)
Query: 56 DAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELG 115
DA +E E+ + +A +M H + K +EK K L++I+ GV++I+VK A
Sbjct: 85 DAAPIAEGLEEAIVDA-DIVMTHFSPIPKYIIEKGKNLKLILTSRGGVEHINVKEASNHN 143
Query: 116 IAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRG 175
I V NV E VAD + L+L++ R +R G+ + G
Sbjct: 144 IPVFNVIR-NAEPVADFALGLMLDITRNITLSDKFIRNGQWMHEYYNTGQIKL----FNG 198
Query: 176 DTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDG--IEKSLG-LTRVYTLQDLLFQSD 232
+G+VG+G +G+A+A R A G ++I YD ++ + ++ LG + +V T++D+ ++D
Sbjct: 199 HLVGLVGIGNVGAAIARRLNALGVSIIAYDSFVSEERLAQQGLGFIKKVETMEDVFKKAD 258
Query: 233 CVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDV 292
VSLH L +INE K M+ A+ +NTARGGL+D++ L +L++G + AALDV
Sbjct: 259 IVSLHLRLTPETEGIINEDYFKLMKKTAYFINTARGGLIDEDALITSLQKGYFKGAALDV 318
Query: 293 HENEP 297
+ EP
Sbjct: 319 VKKEP 323
>UniRef50_A0FZA8 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=3; Burkholderia|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Burkholderia phymatum STM815
Length = 321
Score = 126 bits (303), Expect = 2e-27
Identities = 89/256 (34%), Positives = 129/256 (50%), Gaps = 8/256 (3%)
Query: 46 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDN 105
L+ A V D + + E L +A GA+ + + E L L+++ + G D
Sbjct: 18 LRSHAQVTIVDPKQPGALIE-ALKDADGAI-GTGVKMNAETLADASRLKVLSTVSVGFDA 75
Query: 106 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 165
DV + GI + N P E ADT LIL RR LA V+ GK +++ E
Sbjct: 76 FDVDYLNKRGILLTNTPDVLTESTADTAFSLILLTARRLAELAAFVKAGK---WTKKIAE 132
Query: 166 ASAGCARIRGDTLGIVGLGRIGSAVALRAK-AFGFNVIFYDPYLPDGIEKSLGLTRVYTL 224
G + TLGIVGLGRIG++VA RA F NV++ D + + E+ G RV +
Sbjct: 133 DRFG-VDVHHKTLGIVGLGRIGTSVARRAALGFQMNVLYVDQGVNEKAEREYGAKRV-SF 190
Query: 225 QDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGR 284
+LL SD V L L +LI+ ++ M+ AFL+N +RG +VD+ L AL+ G
Sbjct: 191 DELLKTSDFVLLQAPLTPETRNLISTPQLQAMKRSAFLINASRGPIVDEPALVKALQDGV 250
Query: 285 IRAAALDVHENEPFNV 300
I A LDV++ EP +V
Sbjct: 251 IAGAGLDVYQEEPLSV 266
>UniRef50_P45250 Cluster: Putative 2-hydroxyacid dehydrogenase
HI1556; n=25; cellular organisms|Rep: Putative
2-hydroxyacid dehydrogenase HI1556 - Haemophilus
influenzae
Length = 315
Score = 126 bits (303), Expect = 2e-27
Identities = 79/219 (36%), Positives = 115/219 (52%), Gaps = 8/219 (3%)
Query: 80 IILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILN 139
+I +E L++ L++I +G +N+D+ AA E+GIAV NV GY V + + LI +
Sbjct: 52 VIFDRETLQQLPKLKLIAITATGTNNVDLVAAEEMGIAVRNVTGYSSTTVPEHVIGLIFS 111
Query: 140 L-YRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFG 198
L + WL + K+ +Q +RG TLG+ G G +G+ V A A G
Sbjct: 112 LKHSLAGWLRDQTEA--KWAESKQFCYFDYPITDVRGSTLGVFGKGCLGTEVGRLANAVG 169
Query: 199 FNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRP 258
V++ + D G T ++L Q+D V+LHC L E LIN T+ +M+
Sbjct: 170 MKVLYAEH--KDATVCREGYT---PFDEVLKQADIVTLHCPLTETTKDLINAETLSKMKK 224
Query: 259 GAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
GAFL+NT RG L+D+ L ALK G + AALDV EP
Sbjct: 225 GAFLINTGRGPLIDELALVDALKTGHLGGAALDVMVKEP 263
>UniRef50_Q82XY9 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase; n=2; Nitrosomonas|Rep: D-isomer specific
2-hydroxyacid dehydrogenase - Nitrosomonas europaea
Length = 322
Score = 125 bits (302), Expect = 2e-27
Identities = 78/258 (30%), Positives = 129/258 (50%), Gaps = 9/258 (3%)
Query: 41 VEMPILKDVATV-AFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRI 99
++ +L+ V + + D S ++ E++ + ++ + +L + L+ L++I
Sbjct: 16 IDRTVLEQVVSPWVYHDNTSREQVAERIREAEI--VVSNKTLLDRSALDAANKLKLICVA 73
Query: 100 GSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTG 159
+G +N+D+ AA E I VCNV Y VA +LN R +++ G +
Sbjct: 74 ATGYNNVDLIAAAERNIPVCNVRNYATGSVAQHVFMFMLNFACRFVEYQQLIKRGG-WQA 132
Query: 160 PEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLT 219
G + G TLGIVG G +G+AVA AKAFG ++ + I G T
Sbjct: 133 SSYFCPLDFGITELAGKTLGIVGYGELGNAVANIAKAFGMKLLIAEHKSASTIRP--GRT 190
Query: 220 RVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAA 279
+++ Q+D ++LHC L+E HLI+ + M+P A+L+NTAR GL+D+ L +
Sbjct: 191 ---AFDEVIRQTDFITLHCPLSEDTRHLISNRELNLMKPSAYLINTARSGLIDETDLLKS 247
Query: 280 LKQGRIRAAALDVHENEP 297
L I AA+DV + EP
Sbjct: 248 LYSKHIAGAAIDVLKEEP 265
>UniRef50_Q7MV92 Cluster: Glycerate dehydrogenase; n=1;
Porphyromonas gingivalis|Rep: Glycerate dehydrogenase -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 317
Score = 125 bits (301), Expect = 3e-27
Identities = 73/216 (33%), Positives = 120/216 (55%), Gaps = 3/216 (1%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T D+EK LR I + +G++ ID+ AA + GI + N+P Y E VA + +L++
Sbjct: 55 VTAADMEKMPHLRYIGLMITGLNLIDMDAARQRGITITNIPHYSTESVAQMAISHLLHIT 114
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
L+ V++G + EQ+ + + G T+ IVGLG IG+ VA A+ FG +
Sbjct: 115 MPIGELSRQVKDGCWQSNYEQISRNTYQI-ELSGLTMAIVGLGAIGTRVAEMARGFGMKI 173
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ + P IE + + +L+ L ++D +SLHC L +++ + M+P A
Sbjct: 174 LAHTSKSP--IELPSYIEKSDSLEKLFSRADVLSLHCPLTAQTQRMVSADRLALMKPTAI 231
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L+N +RG L+D++ LA+AL +GR+ AA LDV EP
Sbjct: 232 LLNMSRGSLIDEKALASALNEGRLYAAGLDVLAEEP 267
>UniRef50_Q2BHH2 Cluster: Glycerate dehydrogenase; n=1;
Neptuniibacter caesariensis|Rep: Glycerate dehydrogenase
- Neptuniibacter caesariensis
Length = 315
Score = 125 bits (301), Expect = 3e-27
Identities = 79/216 (36%), Positives = 117/216 (54%), Gaps = 6/216 (2%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
L+ + L + L+ I + +G + +D +AA EL I V N YGV+ V +IL L+
Sbjct: 54 LSADLLSQADRLKYISVLATGTNVVDKQAASELSIPVSNCVAYGVDSVVQHVWSMILALH 113
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
+N VR+G+ + +Q + + ++G TLGIVG G +G VA A+AFG V
Sbjct: 114 TNLVNYSNDVRQGE-WQKAQQFCFFNHPISELKGKTLGIVGYGNLGQGVAKIAEAFGMQV 172
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ + PD E G T+ + SD +SLHC L E +L E T ++M+ A
Sbjct: 173 LIANR--PDDAELKAGRVLFDTVVE---NSDVISLHCPLTEGTRNLFIEETFRKMKGSAM 227
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L+N ARGG+V++E LA+AL+ I AAA DV EP
Sbjct: 228 LINAARGGIVNEEDLASALRNHEIAAAATDVLSVEP 263
>UniRef50_O28495 Cluster: 2-hydroxyacid dehydrogenase, putative;
n=4; Archaea|Rep: 2-hydroxyacid dehydrogenase, putative
- Archaeoglobus fulgidus
Length = 323
Score = 125 bits (301), Expect = 3e-27
Identities = 78/218 (35%), Positives = 116/218 (53%), Gaps = 6/218 (2%)
Query: 80 IILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILN 139
I +T+E + + +++I + +G +NIDV+AA +L I V NV G VA+ T+ L
Sbjct: 58 IPITEEMMRAMEKVKLIQQPSTGYNNIDVEAAKKLSITVANVGGVNALSVAEHTVMFALA 117
Query: 140 LYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGF 199
L RR + N V G+ EQ A+ G + G T GI+G+G G V R + +G
Sbjct: 118 LLRRLIYAHNSVLSGRW----EQDEMANLGVYELHGKTWGIIGMGAQGREVTKRLQGWGV 173
Query: 200 NVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPG 259
+I++D + IE+ G+ LL ++D VSLH L E +I E +K M+
Sbjct: 174 KIIYHDVRRAEDIEE-YGV-EFRDFDALLREADIVSLHVPLTEETRGMIGERELKMMKNS 231
Query: 260 AFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
A L+N ARG +VD+ L A+K+ I AALDV EP
Sbjct: 232 AILINVARGEVVDENALVRAIKERWIAGAALDVFAKEP 269
>UniRef50_A0RW58 Cluster: Phosphoglycerate dehydrogenase; n=3;
Crenarchaeota|Rep: Phosphoglycerate dehydrogenase -
Cenarchaeum symbiosum
Length = 310
Score = 125 bits (301), Expect = 3e-27
Identities = 78/217 (35%), Positives = 114/217 (52%), Gaps = 9/217 (4%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T E + K +II R+G G+DNID+ AA G+ V N V++ + ++L +
Sbjct: 57 ITGEIIRSAKDCKIIARVGVGLDNIDLAAAESAGVRVINAVEGATTAVSELVLGMMLCMA 116
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R+ +R GK G G ++G LGIVGLG IG + A+ N+
Sbjct: 117 RQIPRADRGIRGGKWLKG-------ELGGTELKGKYLGIVGLGNIGRRLGRLARGMNMNI 169
Query: 202 IFYDPYLPDG-IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
I +D D + +GL + L LL SD VSLH L + H+IN + M+P +
Sbjct: 170 IGHDVVPIDAEFSREVGLMKT-DLNTLLGSSDYVSLHVPLLDSTRHMINAEKLALMKPTS 228
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+VNT+RGG++D++ L AL GRI AALDV E+EP
Sbjct: 229 RIVNTSRGGIIDEDALYEALSGGRIAGAALDVFESEP 265
>UniRef50_O32264 Cluster: Probable 2-ketogluconate reductase; n=1;
Bacillus subtilis|Rep: Probable 2-ketogluconate
reductase - Bacillus subtilis
Length = 325
Score = 125 bits (301), Expect = 3e-27
Identities = 90/241 (37%), Positives = 127/241 (52%), Gaps = 10/241 (4%)
Query: 61 SEIHEKVLNEAVGALMWHTI--ILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAV 118
S++ + L EA G L T + +E LE L+++ G DN D++A E G+
Sbjct: 36 SDVLFEKLKEAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVG 95
Query: 119 CNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTL 178
+ P + VAD LIL+ RR L VR GK T E EA G + TL
Sbjct: 96 THTPYTLDDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEE---EALFGID-VHHQTL 151
Query: 179 GIVGLGRIGSAVALRAKAFGFN--VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSL 236
GI+G+GRIG A RAK FGF+ V++++ + E S+G+ + L LL QSD + L
Sbjct: 152 GIIGMGRIGEQAARRAK-FGFDMEVLYHNRHRKQETEDSIGV-KYAELDTLLEQSDFILL 209
Query: 237 HCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
L + +H+I E K M+ A VN +RG VD++ L AL++G IR A LDV+E E
Sbjct: 210 ITPLTDETYHMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKE 269
Query: 297 P 297
P
Sbjct: 270 P 270
>UniRef50_Q1MPI0 Cluster: Lactate dehydrogenase and related
dehydrogenases; n=2; Desulfovibrionaceae|Rep: Lactate
dehydrogenase and related dehydrogenases - Lawsonia
intracellularis (strain PHE/MN1-00)
Length = 323
Score = 124 bits (300), Expect = 4e-27
Identities = 76/222 (34%), Positives = 113/222 (50%), Gaps = 8/222 (3%)
Query: 81 ILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNL 140
ILT E +E+ L+ I +G+G + ID++ AG+ GI V NV YGV+ VA L+L L
Sbjct: 54 ILTTEHIEELPKLKCIGVLGTGYNQIDIETAGKRGIPVINVTAYGVDAVAQHAFALLLEL 113
Query: 141 YRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
R T L +R G ++ P+ + GI+G G IG A F +
Sbjct: 114 CRHTAALDQAIRNGA-WSSPDWAPWKYPQ-VELTYKCFGIIGYGNIGQKAGYIAHGFDMS 171
Query: 201 VIFYD--PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRP 258
V+ YD P P S L ++ +D +SLHC L E N HL+N+ I+ M+
Sbjct: 172 VLAYDERPVQPP----SYTPFSFADLDEVFKNADVLSLHCPLTEDNFHLVNKKRIETMKD 227
Query: 259 GAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNV 300
GA ++N ARG L+D++ +A AL G++ D +EP N+
Sbjct: 228 GAIIINVARGALLDEQAVADALISGKLGGLGSDAFVDEPINL 269
>UniRef50_Q11SX0 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=1; Cytophaga
hutchinsonii ATCC 33406|Rep: D-isomer specific
2-hydroxyacid dehydrogenase family protein - Cytophaga
hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Length = 310
Score = 124 bits (300), Expect = 4e-27
Identities = 78/211 (36%), Positives = 106/211 (50%), Gaps = 5/211 (2%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
LE L++I +G +NID++ A L I V NV GY VA T I+ LY R +
Sbjct: 59 LELLPNLKLICVAATGTNNIDLEKAAALNIPVKNVKGYSTNSVAQLTFGFIIELYNRISF 118
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
V+E + ++ + G I G T+GI+G+G IG AVA A AF V +Y
Sbjct: 119 YDTYVKE-EMYSSQQLFTHIGPGLEEIAGKTIGIIGMGDIGKAVAKIAAAFNMQVQYYST 177
Query: 207 YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
G G V +L+ LL SD VS+H N LI + M+ A L+N
Sbjct: 178 ---SGKNTDAGYPSV-SLEVLLKTSDVVSIHAPFNPQTSQLIGAKQLAMMKSDAVLINVG 233
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
RGG+V + L AL++ +I AAALDV E EP
Sbjct: 234 RGGIVVEADLVRALEEKKIYAAALDVFEQEP 264
>UniRef50_Q0FY56 Cluster: Putative phosphoglycerate dehydrogenase
protein; n=1; Fulvimarina pelagi HTCC2506|Rep: Putative
phosphoglycerate dehydrogenase protein - Fulvimarina
pelagi HTCC2506
Length = 322
Score = 124 bits (300), Expect = 4e-27
Identities = 81/212 (38%), Positives = 114/212 (53%), Gaps = 9/212 (4%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
LE LR +VR G+G+D I V+AA LGIAV N P + VA+ LI+ L RR
Sbjct: 53 LENAPKLRALVRHGAGLDFIPVQAASRLGIAVTNTPSVNAKSVAEHVFGLIICLARRIVE 112
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAK-AFGFNVIFYD 205
+R + +R A+ G I G LG++G G IG A+A K FG NV+
Sbjct: 113 NDAGIRRNEWHA----LRAAAPGSCEIAGKALGLIGYGGIGQAIAQIGKLGFGMNVLAAT 168
Query: 206 PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNT 265
+ P E + + L D+ ++D + + C L+E +L++E I M P A LVN
Sbjct: 169 RW-PREDEDGVSF---HPLTDVAAKADILVVACPLSEETRNLVSEEIIAAMPPNAILVNV 224
Query: 266 ARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
ARG +VD+ L+AAL+ G IR AALDV ++P
Sbjct: 225 ARGPIVDEAALSAALRAGHIRGAALDVFSDQP 256
>UniRef50_O04130 Cluster: D-3-phosphoglycerate dehydrogenase,
chloroplast precursor; n=13; Magnoliophyta|Rep:
D-3-phosphoglycerate dehydrogenase, chloroplast
precursor - Arabidopsis thaliana (Mouse-ear cress)
Length = 624
Score = 124 bits (300), Expect = 4e-27
Identities = 78/244 (31%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Query: 55 CDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKA-LRIIVRIGSGVDNIDVKAAGE 113
C + E +K + E+ ++ +T+E E K L+++ R G G+DN+D++AA E
Sbjct: 107 CSYDLSPEDLKKKVAESDALIVRSGTKVTREVFEAAKGRLKVVGRAGVGIDNVDLQAATE 166
Query: 114 LGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARI 173
G V N P A+ + L+ ++ R ++ GK R G + +
Sbjct: 167 HGCLVVNAPTANTVAAAEHGIALLASMARNVAQADASIKAGK------WERSKYVGVSLV 220
Query: 174 RGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDC 233
G TL ++G G++G+ VA RAK G VI +DPY P ++LG+ V + + +D
Sbjct: 221 -GKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRARALGVDLV-SFDQAISTADF 278
Query: 234 VSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVH 293
VSLH L + N+ T +M+ G L+N ARGG++D++ L AL G + AALDV
Sbjct: 279 VSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALDVF 338
Query: 294 ENEP 297
EP
Sbjct: 339 CEEP 342
>UniRef50_Q88YI0 Cluster: Phosphoglycerate dehydrogenase; n=5;
Bacilli|Rep: Phosphoglycerate dehydrogenase -
Lactobacillus plantarum
Length = 324
Score = 124 bits (299), Expect = 5e-27
Identities = 77/206 (37%), Positives = 116/206 (56%), Gaps = 6/206 (2%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L++I G+G +NID+ AA + I V N P A++T+ LI++L R +++R
Sbjct: 68 LKLIANFGAGTNNIDIAAAAKRQIPVTNTPNVSAVATAESTVGLIISLAHRIVEGDHLMR 127
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY-LPDG 211
F G + ++G TLGI+GLG+IG AVA R AF +++ + LP
Sbjct: 128 TSG-FNGWAPLFFLGHN---LQGKTLGILGLGQIGQAVAKRLHAFDMPILYSQHHRLPIS 183
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
E LG T V + +LL ++D V+LH L HLI+ +M+ A L+N ARG +V
Sbjct: 184 RETQLGATFV-SQDELLQRADIVTLHLPLTTQTTHLIDNAAFSKMKSTALLINAARGPIV 242
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
D++ L AL+Q +I AALDV+E+EP
Sbjct: 243 DEQALVTALQQHQIAGAALDVYEHEP 268
>UniRef50_Q5LT44 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=16; Proteobacteria|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase family
protein - Silicibacter pomeroyi
Length = 330
Score = 124 bits (299), Expect = 5e-27
Identities = 83/206 (40%), Positives = 108/206 (52%), Gaps = 6/206 (2%)
Query: 94 RIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVRE 153
R++ G G +ID A GI V N P E AD M L+L + RR +R
Sbjct: 78 RLLANYGVGYSHIDSDAVRAHGITVSNTPDVLSECTADIAMTLMLMVARRAGEGERELRA 137
Query: 154 GKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAK-AFGFNVIFYD-PYLPDG 211
G+ +TG R +++ G LGIVG GRIG A+A RA FG ++ + +P
Sbjct: 138 GQ-WTG---WRPTHLVGSKVSGKVLGIVGFGRIGQAMAQRAHHGFGMKILVQNRSAVPQD 193
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
+ G T+V TL +L Q D VSLHC N HLIN + M+P AFL+NTARG +V
Sbjct: 194 VLDRYGATQVETLDAMLPQCDFVSLHCPGGAANRHLINSRRLDLMKPDAFLINTARGEVV 253
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
D+ LA AL I AALDV + EP
Sbjct: 254 DEHALAQALMFDCIGGAALDVFDGEP 279
>UniRef50_Q5U922 Cluster: (R)-2-hydroxyisocaproate dehydrogenase;
n=7; Clostridium|Rep: (R)-2-hydroxyisocaproate
dehydrogenase - Clostridium difficile
Length = 331
Score = 124 bits (299), Expect = 5e-27
Identities = 76/208 (36%), Positives = 113/208 (54%), Gaps = 8/208 (3%)
Query: 89 KFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLA 148
K +++I +GVD I E G+ V NVP Y +A+ + +NL R+T +
Sbjct: 66 KDAGVKVIASRTAGVDMIHFDLVNENGLIVTNVPSYSPNAIAELAVTQAMNLLRKTPLVK 125
Query: 149 NMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYL 208
V EG + E +R T+G++G G+IG+ A K G NVI +D Y
Sbjct: 126 KKVCEGDY----RWIAELLG--TEVRSITVGVIGTGKIGATSAKLFKGLGANVIAFDQY- 178
Query: 209 PDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARG 268
P+ + LT +L+DLL ++D ++LH L E H+IN+ T+ M+ GA++VNT RG
Sbjct: 179 PNSDLNDI-LTYKDSLEDLLKEADLITLHTPLLEGTKHMINKDTLAIMKDGAYIVNTGRG 237
Query: 269 GLVDDEGLAAALKQGRIRAAALDVHENE 296
GL++ L AL+ G+IRAAALD E E
Sbjct: 238 GLINTGDLIEALESGKIRAAALDTFETE 265
>UniRef50_A7NGZ0 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase NAD-binding; n=1; Roseiflexus castenholzii
DSM 13941|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase NAD-binding - Roseiflexus castenholzii DSM
13941
Length = 345
Score = 124 bits (299), Expect = 5e-27
Identities = 94/285 (32%), Positives = 132/285 (46%), Gaps = 35/285 (12%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L I R G GVDNID+ AA E GI V N P E A+ + L+L L ++ +V
Sbjct: 70 LMAIARPGIGVDNIDLAAATERGILVINTPDGPTESTAEHAVALVLALAKQ------VVA 123
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA-LRAKAFGFNVIFYDPYLPDG 211
+F G +RG TLG+VGLGRIG VA + + G V YDP P
Sbjct: 124 ADHRFRTAGWSAARLRG-VEVRGKTLGVVGLGRIGRRVAQICRQGLGMRVAAYDPLAPAE 182
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
+L + V TL +LL QS+ ++LHC+L LI + + GAFL+N +RG ++
Sbjct: 183 AFAALDVVHVETLDNLLPQSEFLTLHCALTPSTRGLIGARELALLPKGAFLINVSRGAVI 242
Query: 272 DDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPL 331
D L AL G + A LDV + EP N H PL
Sbjct: 243 DQAALIDALTTGHLAGAGLDVFDPEPLP------NDH---------------------PL 275
Query: 332 KDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRN 376
P+++ TPH A ++D + + A ++I R + G P + N
Sbjct: 276 LQFPHVILTPHIASFTDDGVRVMHHGAVAQIVRLLRGEHPPHIVN 320
>UniRef50_A6GPV1 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, catalytic region:D- isomer specific
2-hydroxyacid dehydrogenase; n=1; Limnobacter sp.
MED105|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, catalytic region:D- isomer specific
2-hydroxyacid dehydrogenase - Limnobacter sp. MED105
Length = 309
Score = 124 bits (299), Expect = 5e-27
Identities = 79/212 (37%), Positives = 110/212 (51%), Gaps = 6/212 (2%)
Query: 86 DLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTY 145
+L+ L++I + +G DN+D A E GI V NV YG E VA+ M IL L RR
Sbjct: 56 ELDAAPKLKMIQLVATGTDNVDKVACAERGIKVSNVVNYGPESVAEHAMACILQLTRRVP 115
Query: 146 WLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYD 205
+V +G ++ + + TLG++G G IG + AKAFG ++ +
Sbjct: 116 EWEALVHDGS-WSASRFFCLHTLPMRGLHTQTLGVLGSGAIGGKLIEFAKAFGMTILHIE 174
Query: 206 PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNT 265
G++K T + L SD +SLHC LNE LI TI +M+ GA L+NT
Sbjct: 175 R---QGVDKPRD--GYVTFEHGLAHSDVLSLHCPLNEQTKGLIGPDTIPKMKKGAILINT 229
Query: 266 ARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
ARGGLV + L A++ G + AALDV E EP
Sbjct: 230 ARGGLVQFDALKQAIESGHLGGAALDVLEVEP 261
>UniRef50_Q9LMM9 Cluster: F22L4.6 protein; n=22; core
eudicotyledons|Rep: F22L4.6 protein - Arabidopsis
thaliana (Mouse-ear cress)
Length = 1284
Score = 124 bits (299), Expect = 5e-27
Identities = 89/281 (31%), Positives = 136/281 (48%), Gaps = 15/281 (5%)
Query: 19 PIANGPLQSRPLVALLDG-RDCTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMW 77
P + P + P V L+ DC +E L VA V + S I + + A L+
Sbjct: 341 PHRDQPSPASPHVVTLNCIEDCALEQDSLAGVAGVEYVPL---SRIADGKIESATAVLLH 397
Query: 78 HTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLI 137
L + + + ++I+ +GS +D A +LG+ + +V EE+ADT M LI
Sbjct: 398 SLAYLPRAAQRRLRPHQLILCLGSADRAVDSTLAADLGLRLVHVDTSRAEEIADTVMALI 457
Query: 138 LNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAF 197
L L RRT+ L+ + G ++ G R RG LGIVG +A R+ AF
Sbjct: 458 LGLLRRTHLLSRHALSASGWLG--SLQPLCRGMRRCRGMVLGIVGRSVSARYLASRSLAF 515
Query: 198 GFNVIFYDPYLPDGIEKSL-------GLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINE 250
+V+++D +P+G E+ + R+ TL DLL SD +SLHC+L ++N
Sbjct: 516 KMSVLYFD--VPEGDEERIRPSRFPRAARRMDTLNDLLAASDVISLHCALTNDTVQILNA 573
Query: 251 FTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALD 291
++ ++PGAFLVNT L+DD + L G I ALD
Sbjct: 574 ECLQHIKPGAFLVNTGSCQLLDDCAVKQLLIDGTIAGCALD 614
>UniRef50_Q9RUU0 Cluster: D-3-phosphoglycerate dehydrogenase; n=4;
Deinococci|Rep: D-3-phosphoglycerate dehydrogenase -
Deinococcus radiodurans
Length = 544
Score = 124 bits (298), Expect = 7e-27
Identities = 78/219 (35%), Positives = 116/219 (52%), Gaps = 12/219 (5%)
Query: 83 TKEDLEKFKA----LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLIL 138
TK D E A L++I R G GVDNID++ A G+ V N P A+ + ++
Sbjct: 67 TKVDRELLDAAGPRLKVIGRGGVGVDNIDLEYASRRGLLVLNAPESNNVSAAELAVMHLM 126
Query: 139 NLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFG 198
R + R +K E R+ + TLGIVGLGRIGS VA RA+
Sbjct: 127 AAAR------GLTRSDRKTRAGEWDRKFLG--LELTDKTLGIVGLGRIGSIVADRAQGLH 178
Query: 199 FNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRP 258
NV+ YDPY+P+ + LG+ R +L +LL Q D +++H L + +I E + ++
Sbjct: 179 MNVVAYDPYVPENKFERLGVQRAASLDELLGQVDALTVHTPLTDETRGMIGERELALLKR 238
Query: 259 GAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
A +VN ARGG+++++ L AL G + AA +DV +EP
Sbjct: 239 DAIVVNAARGGIIEEQALVNALHAGHLFAAGVDVFVDEP 277
>UniRef50_A7FYM9 Cluster: D-lactate dehydrogenase; n=4; Clostridium
botulinum|Rep: D-lactate dehydrogenase - Clostridium
botulinum (strain ATCC 19397 / Type A)
Length = 336
Score = 124 bits (298), Expect = 7e-27
Identities = 88/283 (31%), Positives = 140/283 (49%), Gaps = 27/283 (9%)
Query: 84 KEDLEKFK--ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+E LEK K ++ + +GV+NID AA E GI V NVP Y V++ T+ L L+L
Sbjct: 63 REALEKIKDCGIKYLATRTAGVNNIDFDAAKEFGINVANVPAYSPNSVSEFTIGLALSLT 122
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN- 200
R+ + V G G +R TLG++G GRIG V FG
Sbjct: 123 RKIPFALKRVELNNFALG------GLIG-VELRNLTLGVIGTGRIGLKVIEGFSGFGMKK 175
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
+I YD + + +K + +L ++ ++D ++LH L + N+H+I + +I +M+ G
Sbjct: 176 MIGYDIFENEEAKKYI---EYKSLDEVFKEADIITLHAPLTDDNYHMIGKESIAKMKDGV 232
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXX 320
F++N ARG L+D E L LK G+I AALD +E E Q + ++
Sbjct: 233 FIINAARGALIDSEALIEGLKSGKIAGAALDSYEYE-----QGVFHNNKMNEIMQDDT-- 285
Query: 321 XCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIR 363
L++ LK PN++ TPH FY+D + + E+ ++
Sbjct: 286 -----LER--LKSFPNVVITPHLGFYTDEAVSNMVEITLMNLQ 321
>UniRef50_A4ARG6 Cluster: D-3-phosphoglycerate dehydrogenase; n=14;
Bacteroidetes|Rep: D-3-phosphoglycerate dehydrogenase -
Flavobacteriales bacterium HTCC2170
Length = 329
Score = 124 bits (298), Expect = 7e-27
Identities = 91/261 (34%), Positives = 136/261 (52%), Gaps = 20/261 (7%)
Query: 48 DVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNID 107
+++T Q I+E N+ G L+ + K+ ++ +L++I R G G+DNID
Sbjct: 36 EISTTTVAQEQLKEFINE---NQIAGLLVRSATQVRKDIIDNCPSLKLIGRGGVGMDNID 92
Query: 108 VKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWL-ANMVREG-KKFTGPEQVRE 165
V A E G+ V N P E VA+ + R Y NM EG KF +Q+++
Sbjct: 93 VAYAKEKGLHVINTPAASSESVAELVFAHLFGGVRFLYDANRNMPLEGDSKF---KQLKK 149
Query: 166 ASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY-------LP--DGIEKSL 216
+ AG + +RG TLG++G GRIG A A A G VI+ DP+ LP DG + S
Sbjct: 150 SYAGGSELRGKTLGVIGFGRIGQATAKIALGIGMKVIYSDPFIEKASIELPFFDGQKVSF 209
Query: 217 GLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGL 276
+ +LL +D +SLH + +EF+I M+ G LVN ARGG++D+ L
Sbjct: 210 DFVS-KSKSELLQNADFISLHVPAQKEYVIGKDEFSI--MKNGVGLVNAARGGVIDEVAL 266
Query: 277 AAALKQGRIRAAALDVHENEP 297
AL++G++ A LDV E+EP
Sbjct: 267 VDALEEGKVSFAGLDVFESEP 287
>UniRef50_Q8TR50 Cluster: Glycerate dehydrogenase; n=2;
Methanosarcina|Rep: Glycerate dehydrogenase -
Methanosarcina acetivorans
Length = 319
Score = 124 bits (298), Expect = 7e-27
Identities = 82/228 (35%), Positives = 119/228 (52%), Gaps = 10/228 (4%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
++ E L L++I +G DN+D++ A + G+ V NVP Y E VA+ L LNL
Sbjct: 55 VSAEALRSAPRLKMISLWQTGFDNVDLEEATDHGVIVSNVPSYAFESVAEFVFALTLNLL 114
Query: 142 RRTYWLANM-VREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
RR + LA+M +REG F V ++ T+G++G G IG V A F N
Sbjct: 115 RRVH-LADMNLREGL-FDWKYYVGN------QLMSKTIGVLGTGEIGKRVIQIAHGFNMN 166
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
V+ + K+LG+ V L LL +SD V+LH L H+I + +M+P A
Sbjct: 167 VLSVTAHPSPERAKALGVKFV-DLDTLLSESDIVTLHVPLTPETEHMIGARELAKMKPTA 225
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGH 308
L+NTARG +V++ L ALK+ +I A LDV E EP ++ L H
Sbjct: 226 ILINTARGKVVEEAALMEALKEKKIAGAGLDVFEREPLSMDSPLLEMH 273
>UniRef50_Q8R8Q2 Cluster: Lactate dehydrogenase and related
dehydrogenases; n=8; cellular organisms|Rep: Lactate
dehydrogenase and related dehydrogenases -
Thermoanaerobacter tengcongensis
Length = 358
Score = 123 bits (297), Expect = 9e-27
Identities = 80/207 (38%), Positives = 114/207 (55%), Gaps = 9/207 (4%)
Query: 95 IIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEE-VADTTMCLILNLYRRTYWLANMVRE 153
+I R G G D ID+++A + G V V G E VA+ + L+L++ R+ + V+E
Sbjct: 97 LIARHGIGYDAIDIESATKKGTIVTIVEGIVEREAVAENAVALLLDVMRKVREASIKVKE 156
Query: 154 GKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAK-AFGFNVIFYDPYLPDGI 212
GK A+ I+G T GI+G+G IGS VA K FG VI YDP L
Sbjct: 157 GKWH------ERANFIGYEIKGKTAGIIGIGNIGSRVAEILKYGFGAEVIAYDPNLSKE- 209
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
E R +L++LL SD +SL+ SLNE N+H+++ M+ F+VNTARG L+D
Sbjct: 210 EIIKREARPVSLEELLRSSDIISLNASLNERNYHMLSYKEFSMMKNNVFIVNTARGELID 269
Query: 273 DEGLAAALKQGRIRAAALDVHENEPFN 299
E L AL++G++ LDV E EP +
Sbjct: 270 TEALIKALREGKVAGVGLDVVEGEPID 296
>UniRef50_A1HM37 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=3; cellular organisms|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Thermosinus carboxydivorans Nor1
Length = 365
Score = 123 bits (297), Expect = 9e-27
Identities = 77/216 (35%), Positives = 116/216 (53%), Gaps = 11/216 (5%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
LRI+ +G++N++VK A + GI V N+ G E V+D T+ L+L R ++
Sbjct: 96 LRIVGVSRAGLENVNVKEATKRGILVFNIEGRNAEAVSDFTVGLMLAECRNIARAHYSIK 155
Query: 153 EG---KKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLP 209
G K+F+ + V E ++G +G+VG G IG VA + FG + YDP++
Sbjct: 156 NGGWRKEFSNSDWVPE-------LKGKKVGLVGFGYIGRLVAQKLSGFGVTRLVYDPFVD 208
Query: 210 DGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGG 269
+ + G V + L +SD +SLH L+E +L+ E I M+P A+L+NTAR G
Sbjct: 209 EETIRGAGCIPV-DKETLFKESDFISLHARLSESTKNLVGEKEISLMKPTAYLINTARAG 267
Query: 270 LVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYL 305
LVD+ L AAL++ RI A LDV EP +L
Sbjct: 268 LVDENALLAALREKRIAGAGLDVFNFEPLKPDSEFL 303
>UniRef50_Q6MY49 Cluster: NAD-dependant D-isomer specific
2-hydroxyacid dehydrogenase, putative; n=5;
Eurotiomycetidae|Rep: NAD-dependant D-isomer specific
2-hydroxyacid dehydrogenase, putative - Aspergillus
fumigatus (Sartorya fumigata)
Length = 335
Score = 123 bits (297), Expect = 9e-27
Identities = 74/208 (35%), Positives = 117/208 (56%), Gaps = 11/208 (5%)
Query: 91 KALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANM 150
K+L+ I G+G DNID+ A E GIAV + P AD + L++ R+ Y +
Sbjct: 75 KSLKYICHNGAGYDNIDIPACSEKGIAVSSTPVAVNHATADVGIFLMIGALRQAYIPLSA 134
Query: 151 VREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYD-PYLP 209
+R G+ + G + +G LGI+G+G IG +A RA+AFG + +++ L
Sbjct: 135 LRAGQ-WQGKTTLGHDP------QGKVLGILGMGGIGREMANRARAFGMKIQYHNRSRLS 187
Query: 210 DGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGG 269
+E G + + +LL +D +SL+ +LN H+I E ++M+ G +VNTARG
Sbjct: 188 PELE---GDAQYVSFDELLANADVLSLNLALNAKTRHIIGEKEFQKMKDGVVIVNTARGA 244
Query: 270 LVDDEGLAAALKQGRIRAAALDVHENEP 297
L+D++ L AAL G++ +A LDV+ENEP
Sbjct: 245 LIDEKALVAALDSGKVMSAGLDVYENEP 272
>UniRef50_Q7WM64 Cluster: Putative dehydrogenase; n=2;
Bordetella|Rep: Putative dehydrogenase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 330
Score = 123 bits (296), Expect = 1e-26
Identities = 79/212 (37%), Positives = 111/212 (52%), Gaps = 7/212 (3%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
+E + LR+I G+G + ID+ AA LGI V N PG VA+ + + + L +RT
Sbjct: 62 IEAGRRLRVIGNHGTGTNMIDLAAAERLGIPVVNTPGANARSVAELALAMAMALLKRTVP 121
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRA-KAFGFNVIFYD 205
L VR+G +R AG + G +LGIVG G+IG A+A A FG V Y
Sbjct: 122 LDQAVRQGNW-----NIRY-EAGLRELSGMSLGIVGFGQIGRALAAMAIGGFGMRVHVYS 175
Query: 206 PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNT 265
P + + G R +L L ++D VSLH L+++ + M+PGA L+NT
Sbjct: 176 PSVAPQDIAAAGCQRADSLPALAREADIVSLHRPARPGAGPLVDDALLLAMKPGALLINT 235
Query: 266 ARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
AR LVD+ LA L+ GR+ A LDV +EP
Sbjct: 236 ARADLVDEAALARHLEAGRLGGAGLDVFSSEP 267
>UniRef50_Q1NQ97 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, catalytic region:D- isomer specific
2-hydroxyacid dehydrogenase, NAD-binding; n=2;
Bacteria|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, catalytic region:D- isomer specific
2-hydroxyacid dehydrogenase, NAD-binding - delta
proteobacterium MLMS-1
Length = 304
Score = 123 bits (296), Expect = 1e-26
Identities = 75/216 (34%), Positives = 114/216 (52%), Gaps = 8/216 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T E LE + L+++ R G G+DN+DV AA + G+ V N P A+ + +++ L
Sbjct: 53 VTAEILEAAENLKVVGRAGIGLDNVDVPAASKKGVVVMNAPDGNATTAAEHAVSMMMALT 112
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R ++ GK Q E +A A G+VG+GRIG A RA V
Sbjct: 113 RNIPQATASMKAGKWEKKKFQGHEVTAKVA-------GVVGIGRIGRIFAERAMGLRMKV 165
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
I +DP++P + +G+ V TL++L ++D +S+H L H++ M+P
Sbjct: 166 IAFDPHMPAEQMEKIGVEPV-TLEELCQRADYISVHVPLTPETKHVLGAEQFAMMKPTTM 224
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+V+ ARGG+VD++ L ALK IR AALDV E EP
Sbjct: 225 VVDCARGGVVDEKALYEALKTKTIRGAALDVFEVEP 260
>UniRef50_A7CY19 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase NAD-binding; n=1; Opitutaceae bacterium
TAV2|Rep: D-isomer specific 2-hydroxyacid dehydrogenase
NAD-binding - Opitutaceae bacterium TAV2
Length = 318
Score = 123 bits (296), Expect = 1e-26
Identities = 76/207 (36%), Positives = 108/207 (52%), Gaps = 13/207 (6%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L++I + G G+D IDV A I V PG VA+ T L+L L + + + R
Sbjct: 70 LKVISKYGIGLDKIDVAHATSKKIPVLFTPGVNHTTVAEHTFLLLLALEKNILFHTDSTR 129
Query: 153 EG--KKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPD 210
G K+ TG E + + T+GIVGLGRIG VA+RA+AFG VI YD Y +
Sbjct: 130 SGGWKRKTGHELLAK-----------TIGIVGLGRIGKEVAIRARAFGMEVIAYDIYWDE 178
Query: 211 GIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGL 270
K + RV T +++ +D +SLH +L +IN TI M+ G ++N ARG +
Sbjct: 179 AFAKQHNVKRVATKEEIFTSADYISLHTNLTPETRDMINAKTIATMKKGVLILNCARGEI 238
Query: 271 VDDEGLAAALKQGRIRAAALDVHENEP 297
V + AALK G++ DV + EP
Sbjct: 239 VHTADMVAALKSGQVGGYGADVLDAEP 265
>UniRef50_A6Q7Q2 Cluster: D-3-phosphoglycerate dehydrogenase; n=27;
Epsilonproteobacteria|Rep: D-3-phosphoglycerate
dehydrogenase - Sulfurovum sp. (strain NBC37-1)
Length = 529
Score = 123 bits (296), Expect = 1e-26
Identities = 72/211 (34%), Positives = 109/211 (51%), Gaps = 7/211 (3%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
LE K + IVR G GVDN+D+ + + GI V NVP + T+ +L+ R+ +
Sbjct: 63 LESAKKITAIVRAGVGVDNVDIPGSSKQGIVVMNVPTANTIAAVELTLAHMLSCVRQFPY 122
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
N ++ + + R+ G ++ LGI+G G IGS V RAKAF +V+ YDP
Sbjct: 123 AHNNLKLDRVWR-----RQDWYG-TELKDKKLGIIGFGNIGSRVGKRAKAFEMDVLAYDP 176
Query: 207 YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
Y+ L + +D+L D +++H E +IN+ I +M+ G L+N A
Sbjct: 177 YIDPSKATDLDIGYTKNFEDIL-ACDIITIHTPKTEETIGMINKDEIAKMKDGVILINCA 235
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
RGGL ++E L LK G+I A +DV EP
Sbjct: 236 RGGLYNEEALLEGLKSGKIAMAGIDVFNKEP 266
>UniRef50_A7STU0 Cluster: Predicted protein; n=5; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 332
Score = 123 bits (296), Expect = 1e-26
Identities = 87/250 (34%), Positives = 129/250 (51%), Gaps = 15/250 (6%)
Query: 59 STSEIHEKVLNEAVGALMWHTIILTKEDL-EKFKALRIIVRIGSGVDNIDVKAAGELGIA 117
S+ E+ +K + G + ++ L + + LR+I G GVD+ID+ AA GI
Sbjct: 35 SSDEVSDKNRSRVQGLYIHAGFVVVDSALMDCYPELRVISSAGVGVDHIDLAAATIRGIR 94
Query: 118 VCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDT 177
V N PG E AD + L+L R+ +++R+ G + ++ ++ G T
Sbjct: 95 VGNTPGVVQECTADHAIGLLLASARKICSGDSVIRQ----PGFSKESIFNSFGTKVTGST 150
Query: 178 LGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVY----------TLQDL 227
LGIVGLG +GSAVA RAK F +++++ + E + Y L +L
Sbjct: 151 LGIVGLGGVGSAVANRAKGFKMRILYHNRTRKEDKELETVVLLFYYAFVGAEYCSKLDEL 210
Query: 228 LFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRA 287
L +SD V L C+L + HLI + QM+ A L+N ARGGLV+ + L AL+ G IR
Sbjct: 211 LKESDFVVLCCALTDETRHLITAAQLSQMKSSATLINVARGGLVNHDDLTTALQNGVIRG 270
Query: 288 AALDVHENEP 297
AALDV E EP
Sbjct: 271 AALDVTEPEP 280
>UniRef50_P30799 Cluster: 2-hydroxyacid dehydrogenase homolog; n=34;
cellular organisms|Rep: 2-hydroxyacid dehydrogenase
homolog - Zymomonas mobilis
Length = 331
Score = 123 bits (296), Expect = 1e-26
Identities = 84/248 (33%), Positives = 128/248 (51%), Gaps = 12/248 (4%)
Query: 52 VAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKAL--RIIVRIGSGVDNIDVK 109
+ F + + T E EK +A ++ E LE L +++ +G +N+D+
Sbjct: 27 LVFLNERLTKETAEKA-KDAEAVCIFVNDEANAEVLEILAGLGIKLVALRCAGYNNVDLD 85
Query: 110 AAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAG 169
AA +L I V VP Y VA+ + ++L L R+ VRE F+ E G
Sbjct: 86 AAKKLNIKVVRVPAYSPYSVAEYAVGMLLTLNRQISRGLKRVRENN-FS-----LEGLIG 139
Query: 170 CARIRGDTLGIVGLGRIGSAVA-LRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLL 228
+ T+GI+G+G IGS A + FG NVI Y P+ + K +G R +L +++
Sbjct: 140 LD-VHDKTVGIIGVGHIGSVFAHIMTHGFGANVIAYKPHPDPELAKKVGF-RFTSLDEVI 197
Query: 229 FQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAA 288
SD +SLHC L NHH+INE T+ + + G +LVNT+RGGLVD + + +LK +
Sbjct: 198 ETSDIISLHCPLTPENHHMINEETLARAKKGFYLVNTSRGGLVDTKAVIKSLKAKHLGGY 257
Query: 289 ALDVHENE 296
A DV+E E
Sbjct: 258 AADVYEEE 265
>UniRef50_Q5FUW5 Cluster: D-3-phosphoglycerate dehydrogenase; n=55;
Bacteria|Rep: D-3-phosphoglycerate dehydrogenase -
Gluconobacter oxydans (Gluconobacter suboxydans)
Length = 416
Score = 122 bits (295), Expect = 2e-26
Identities = 85/218 (38%), Positives = 113/218 (51%), Gaps = 14/218 (6%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
LT+E LE L I G + +D+ AA LGI V N P VA+ M I+ L
Sbjct: 66 LTREVLEGADRLMAIGCFCIGTNQVDLNAARMLGIPVFNAPFSNTRSVAELVMGEIVMLL 125
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
RR + +G G ++ ++ +RG TLGIVG G IGS +++ A+AFG V
Sbjct: 126 RRIPSRSEACHKG----GWDK---SATNAWEVRGKTLGIVGYGSIGSQLSVLAEAFGMRV 178
Query: 202 IFYD--PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPG 259
+++D P LP G V TL DLL QSD VSLH LI E I+ M+P
Sbjct: 179 LYFDVMPRLPHG-----NAIAVSTLHDLLAQSDIVSLHVPQTPETDLLIGETEIRAMKPN 233
Query: 260 AFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ L+N ARG +V+ E LA ALK G + A +DV EP
Sbjct: 234 SILLNNARGNVVELEALAVALKDGHLMGAGVDVFPVEP 271
>UniRef50_Q0S7S0 Cluster: Probable phosphoglycerate dehydrogenase;
n=1; Rhodococcus sp. RHA1|Rep: Probable phosphoglycerate
dehydrogenase - Rhodococcus sp. (strain RHA1)
Length = 319
Score = 122 bits (295), Expect = 2e-26
Identities = 81/206 (39%), Positives = 107/206 (51%), Gaps = 8/206 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
LR++ +G D++ V AA E G+ V Y EEVAD + L L L R T+ L V
Sbjct: 65 LRLLSATSAGYDHLPVSAAHERGLWVTRAVDYCTEEVADHALTLTLGLLRSTHALDRSVH 124
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
G G + +A RI G LG+ G GRI A ALRA+A G V+ L D
Sbjct: 125 AG----GWDVT---AAPPRRIAGTVLGLYGFGRIAGAFALRARALGMTVLVSGRGLGDRA 177
Query: 213 -EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
E + V ++LL +SD +SLH L LI E + M+ G +LVN +RGGLV
Sbjct: 178 GELAAEGIEVVGFEELLRRSDVLSLHVPLTSETRGLIGERALAAMKRGGYLVNVSRGGLV 237
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
D + L AAL+ G + AA+DV NEP
Sbjct: 238 DHDALGAALRSGHLAGAAVDVLPNEP 263
Score = 39.9 bits (89), Expect = 0.15
Identities = 17/45 (37%), Positives = 25/45 (55%)
Query: 327 QQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIP 371
Q P+ PNL+ TPHAA+YS A+ L + +A + + G P
Sbjct: 266 QDDPILQIPNLVITPHAAWYSPQVARTLAQQSARNVAAVLTGASP 310
>UniRef50_Q5KQ73 Cluster: D-3-phosphoglycerate dehydrogenase,
putative; n=3; Filobasidiella neoformans|Rep:
D-3-phosphoglycerate dehydrogenase, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 594
Score = 122 bits (295), Expect = 2e-26
Identities = 83/239 (34%), Positives = 127/239 (53%), Gaps = 17/239 (7%)
Query: 70 EAVGALMWHTIILTKEDLEKFKA-----LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGY 124
EA G L+ + + T EDLE+ + L+ I + G+GVD ID+ A +LGI V N PG
Sbjct: 72 EAQGLLVRGSYV-TAEDLERATSMKGGKLKYISKQGTGVDKIDIVNAKKLGIPVMNTPGV 130
Query: 125 GVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLG 184
+ VA+ ++L+L R+T + +R+G T + + + G TLG++G G
Sbjct: 131 NAQAVAELAFGMMLSLARQTPSIDRKIRKGASVTKLDGWKGQM-----LYGKTLGVIGGG 185
Query: 185 RIGSAVA-LRAKAFGFNVIFYDPYLPD-----GIEKSLGLTRVYTLQDLLFQSDCVSLHC 238
IG VA + A AF ++ YDPYL + + +V + +LL SD V++H
Sbjct: 186 NIGLLVAKMFAGAFSGKIVLYDPYLKSLDTWHSAIPNASIHKVSEIDELLTTSDIVTIHV 245
Query: 239 SLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L ++I+ K M+P A L+NTARGG++++E L+ AL I AA LD EP
Sbjct: 246 PLTPSTENMISAPQFKTMKPTAILINTARGGIINEEDLSQALLNEEIFAAGLDAFTVEP 304
>UniRef50_Q65WI5 Cluster: SerA protein; n=1; Mannheimia
succiniciproducens MBEL55E|Rep: SerA protein -
Mannheimia succiniciproducens (strain MBEL55E)
Length = 326
Score = 122 bits (294), Expect = 2e-26
Identities = 74/219 (33%), Positives = 112/219 (51%), Gaps = 6/219 (2%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+ +E + + K L++I R G GVD++DVK A ELGI V PG VA+ L+
Sbjct: 54 IDRETMLQAKNLKVIGRPGVGVDDVDVKTATELGIPVVIAPGSNTRSVAEHAFALMFACA 113
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
+ N +R+G F +R +S + TL ++G GRIGS +A +KA G NV
Sbjct: 114 KDIVRSDNEMRKGN-FA----IR-SSYKAYELNHKTLALIGYGRIGSILAQMSKAIGMNV 167
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
YDP++ G + G L D++ S +S+H L +LI E M
Sbjct: 168 KVYDPFVKQGTIEQEGYIYCTELDDVIRDSHVISIHVPLTNETRNLIGEHEFSLMNEHTI 227
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNV 300
L+N ARG ++D+ L L++G+I +A LDV EP ++
Sbjct: 228 LINCARGEVIDEPVLTKVLQEGKIHSAGLDVFACEPVDI 266
>UniRef50_A1RC54 Cluster: Glyoxylate reductase; n=2;
Actinomycetales|Rep: Glyoxylate reductase - Arthrobacter
aurescens (strain TC1)
Length = 329
Score = 122 bits (294), Expect = 2e-26
Identities = 81/202 (40%), Positives = 104/202 (51%), Gaps = 10/202 (4%)
Query: 102 GVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPE 161
G +NIDV AA GI V N PG + AD M LIL RR +VR+GK F G E
Sbjct: 76 GYNNIDVDAATRHGILVGNTPGVLTDATADVAMLLILGTARRVVESDRVVRDGK-FLGWE 134
Query: 162 QVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYD------PYLPDGIEKS 215
E G + G LG+ G GRI AVA RA FG +F P + + +
Sbjct: 135 P--EFMLG-RDVSGAVLGLAGFGRIARAVARRALGFGMEELFSPRPPGDRPVSDEELGEF 191
Query: 216 LGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEG 275
G R L+ +SD +SLH LNE HL++ + +M+ A L+NTARG +VD+
Sbjct: 192 AGKVRQVPWDSLVERSDFLSLHVPLNEQTRHLVDADVLGRMKSDAILINTARGPVVDESA 251
Query: 276 LAAALKQGRIRAAALDVHENEP 297
L AL+ G I A LDV E+EP
Sbjct: 252 LVEALRNGVIGGAGLDVFEDEP 273
>UniRef50_Q6BTY7 Cluster: Debaryomyces hansenii chromosome C of
strain CBS767 of Debaryomyces hansenii; n=1;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome C of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 339
Score = 122 bits (294), Expect = 2e-26
Identities = 77/206 (37%), Positives = 108/206 (52%), Gaps = 2/206 (0%)
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
+L+ I G+G D IDV + GI + N P + AD + L+L R +
Sbjct: 77 SLKYIAHQGTGYDQIDVDELNKRGIQLSNCPDIVTKSTADMNIFLMLGAMRNFEAGRRNL 136
Query: 152 REGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDG 211
GK G AG A R LGI+G+G IG AV RA +FGF I Y
Sbjct: 137 IAGKWPAGGLGAG-VEAGWAPSR-KVLGIIGMGNIGRAVRDRAVSFGFEKIVYYSRSKLT 194
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
E V +L++L+ SD +S++C LN+ +HLIN+ I +M+ G +VNTARG ++
Sbjct: 195 PELEKDCEYVASLEELVAASDVLSINCPLNKSTYHLINDSLISKMKDGVIIVNTARGAVI 254
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
D++ + LK G+I AA LDV ENEP
Sbjct: 255 DEQDMIKHLKTGKIGAAGLDVFENEP 280
>UniRef50_A7AAD2 Cluster: Putative uncharacterized protein; n=1;
Parabacteroides merdae ATCC 43184|Rep: Putative
uncharacterized protein - Parabacteroides merdae ATCC
43184
Length = 320
Score = 122 bits (293), Expect = 3e-26
Identities = 82/217 (37%), Positives = 119/217 (54%), Gaps = 11/217 (5%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+ KE ++ L+++ G +NIDV E GI V N P A+ + L+L++
Sbjct: 55 VNKELIDHASKLKMVANYAVGYNNIDVAYCLEKGITVANTPDPVTAPTANLALGLMLDVA 114
Query: 142 RR-TYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
RR T + REG G + + G + G TLGI+G+GRIG A+A RA A G
Sbjct: 115 RRITECDRKLRREG---LGMKVGVLENLGI-NVTGKTLGIIGMGRIGKALARRANACGME 170
Query: 201 VIFYDP---YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMR 257
V++++ Y+ + E L +T V + ++LL QSD VSL+ +H+I E +KQM+
Sbjct: 171 VLYHNRRQLYVEE--ETKLNVTYV-SKEELLSQSDFVSLNAPYTPETYHIIGEAELKQMK 227
Query: 258 PGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHE 294
P A L+NT RG LVD++ L ALK G I A LDV E
Sbjct: 228 PTAVLINTGRGPLVDEKALVQALKDGTIHGAGLDVFE 264
>UniRef50_A5ZAS1 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 319
Score = 122 bits (293), Expect = 3e-26
Identities = 76/260 (29%), Positives = 125/260 (48%), Gaps = 5/260 (1%)
Query: 38 DCTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIV 97
D ++ + V + + E+ E++ + V ++ + +L + L K L+ I
Sbjct: 14 DNDIDFSVFNQYGNVTIYQSSTDEEVGERIKDAEV--VLCNKTVLNADKLSKAPNLKYIG 71
Query: 98 RIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKF 157
+G +NID+ GI VCN Y E VA IL+ Y T N + + +
Sbjct: 72 LFATGYNNIDIDYTRAYGITVCNAGDYSTEAVAQHVFAFILHEYN-TVDKYNTFVKNEGW 130
Query: 158 TGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLG 217
E A ++G T+G++G G IG VA A+ FG V+ Y + + +
Sbjct: 131 VNAETFSPFFA-MRELQGKTIGVIGYGSIGRKVADVARVFGMKVMAYSRS-QEKKDPNFR 188
Query: 218 LTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLA 277
+ ++ D+L SD V++HC LNE + ++ N+ K+M+ A +NT+RG +VD+E LA
Sbjct: 189 ILEYASIDDILANSDIVTMHCPLNEDSKYMCNKEFFKKMKKDALFINTSRGNVVDEEALA 248
Query: 278 AALKQGRIRAAALDVHENEP 297
AL I AA+DV EP
Sbjct: 249 WALNNDIIAHAAVDVVSKEP 268
>UniRef50_A0L7J1 Cluster: D-3-phosphoglycerate dehydrogenase; n=3;
Proteobacteria|Rep: D-3-phosphoglycerate dehydrogenase -
Magnetococcus sp. (strain MC-1)
Length = 527
Score = 122 bits (293), Expect = 3e-26
Identities = 72/205 (35%), Positives = 104/205 (50%), Gaps = 7/205 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L++I R G GVDN+D AA + GI V N P A+ + L + R +
Sbjct: 65 LKVIGRAGIGVDNVDTPAASQKGIIVMNTPFGNAITTAELGVTLAMAAARHIPAATASTK 124
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
GK RE + G T G++GLG +G VA R V+ YDP++
Sbjct: 125 AGKWEKSRFMGRE-------LAGKTAGVIGLGNVGRLVAQRLAGLDMKVVAYDPFINKDR 177
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
SLGL V L+DL + D +++H LN+H +L++ + QM+ G LVN ARGG+ +
Sbjct: 178 AISLGLEMVDKLEDLWPRVDLLTVHTPLNDHTRNLVDAKVVAQMKEGVILVNCARGGIYN 237
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
++ L L G+I AA LDV+ EP
Sbjct: 238 EDALYDGLVSGKIYAAGLDVYVQEP 262
>UniRef50_Q2LUG0 Cluster: 2-hydroxyacid dehydrogenase, D-isomer
specific; n=1; Syntrophus aciditrophicus SB|Rep:
2-hydroxyacid dehydrogenase, D-isomer specific -
Syntrophus aciditrophicus (strain SB)
Length = 326
Score = 121 bits (292), Expect = 4e-26
Identities = 80/245 (32%), Positives = 123/245 (50%), Gaps = 7/245 (2%)
Query: 55 CDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGEL 114
C A S + L A ++ + LT+ DL+ LR+I G++++ + +
Sbjct: 44 CVAPCRSSAWKAGLASAEALIVLLSEPLTEADLDLCPNLRVIGTYSVGINHLPITSCQSR 103
Query: 115 GIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGK-KFTGPEQVREASAGCARI 173
GI + N G + AD + L+L+L RR +VR G K P+ + +
Sbjct: 104 GIRIVNTQGVLTDATADLALTLLLSLTRRVREGEALVRSGHWKGWAPDLLLGTG-----L 158
Query: 174 RGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY-LPDGIEKSLGLTRVYTLQDLLFQSD 232
G T GI+G G IG A A R A G VIF++ ++ + + L +LL QSD
Sbjct: 159 TGKTCGILGSGPIGRAFARRVWAIGMKVIFWNREGNQKPVDFGVDIAARLPLDELLRQSD 218
Query: 233 CVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDV 292
+SLHC L + L+N + + GAFL+NTARGG++D++ + L QG+I LDV
Sbjct: 219 VLSLHCPLTDTTRGLLNREKLDLLPHGAFLINTARGGILDEQAVMELLHQGKIGGVGLDV 278
Query: 293 HENEP 297
+ENEP
Sbjct: 279 YENEP 283
>UniRef50_Q7XAP0 Cluster: C-terminal binding protein; n=3;
Marchantia polymorpha|Rep: C-terminal binding protein -
Marchantia polymorpha (Liverwort)
Length = 688
Score = 121 bits (292), Expect = 4e-26
Identities = 91/270 (33%), Positives = 129/270 (47%), Gaps = 12/270 (4%)
Query: 29 PLVALLDGRD-CTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDL 87
PLV L+ D C E L+ VA V + +++ E + AV L+ L +
Sbjct: 54 PLVVALNCMDDCRAEAEALEGVAVV---EHVGLAQVGEGKIEAAVAVLVQSLAYLPRAAQ 110
Query: 88 EKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWL 147
+ + ++I+ +G +D A +LG+ + +V EEVADT M LIL L RRT L
Sbjct: 111 RRLQPWQLILSLGCADKAVDSGLASDLGLQLLHVDSGRSEEVADTAMALILGLLRRTPAL 170
Query: 148 ANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY 207
A + G + A G R RG LGI+G A+A R +F VI+ D
Sbjct: 171 AAQAGASAGWLGA--LPAACRGMRRCRGQVLGIIGTSASACALATRCLSFKMRVIYLDTE 228
Query: 208 LP-DGIEKSLG-----LTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
DG + + + L++LL SD VSLHC L +IN TIK ++PGA
Sbjct: 229 EERDGDRRHRRAFPPLVKKSENLKELLSLSDVVSLHCPLTNETVQIINAETIKYIKPGAL 288
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALD 291
LVNT+ L+DD L AL +G + ALD
Sbjct: 289 LVNTSSSHLLDDCALKEALIEGTLAGCALD 318
>UniRef50_A7EUN0 Cluster: Formate dehydrogenase; n=2;
Sclerotiniaceae|Rep: Formate dehydrogenase - Sclerotinia
sclerotiorum 1980
Length = 436
Score = 121 bits (292), Expect = 4e-26
Identities = 81/225 (36%), Positives = 115/225 (51%), Gaps = 9/225 (4%)
Query: 77 WHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGEL--GIAVCNVPGYGVEEVADTTM 134
+H LT E L K K L+I + G G D++D+ AA + GI V V G V VA+ +
Sbjct: 132 FHPGYLTAERLAKAKNLKIAITAGIGSDHVDLNAANKTNGGITVAEVTGSNVVSVAEHVV 191
Query: 135 CLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRA 194
IL L R ++ G+ V A+ + G +G V +GRIG V R
Sbjct: 192 MTILVLVRNFVPAHEQIQAGEW-----DVAAAAKNEFDLEGKVVGTVAVGRIGERVLRRL 246
Query: 195 KAFGFNVIFYDPYLP--DGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFT 252
K F + Y Y P IEK +G RV L+++L Q D V+++C L+E L N+
Sbjct: 247 KPFDCKELLYFDYQPLKPEIEKEIGCRRVTDLEEMLAQCDVVTINCPLHEKTRGLFNKEL 306
Query: 253 IKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
I +M+ G++LVNTARG +V E +A ALK G +R DV +P
Sbjct: 307 ISKMKKGSWLVNTARGAIVVKEDVADALKSGHLRGYGGDVWFPQP 351
>UniRef50_Q3IFC5 Cluster: 2-hydroxyacid dehydrogenase family
protein; n=2; Alteromonadales|Rep: 2-hydroxyacid
dehydrogenase family protein - Pseudoalteromonas
haloplanktis (strain TAC 125)
Length = 314
Score = 121 bits (291), Expect = 5e-26
Identities = 75/223 (33%), Positives = 117/223 (52%), Gaps = 7/223 (3%)
Query: 75 LMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTM 134
L+ + ++ +E + + K+L++I +G +N+D+ AA ELGIAV NV GY V T
Sbjct: 46 LITNKAVVNRETMSQLKSLKLICVSATGTNNVDLVAAKELGIAVTNVAGYSTPSVVQHTF 105
Query: 135 CLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRA 194
LI NL T+ ++G + E ++ T I+G G +GSAVA A
Sbjct: 106 SLITNLLGNTHRYQADCQQGA-WQKSEMFCRLDYSFNDLQDKTFAIIGGGTLGSAVATVA 164
Query: 195 KAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIK 254
AFG NVI + G + G R+ + + +D +S+HC L + LI +K
Sbjct: 165 SAFGANVITAER---KGTQCREG--RI-PFEQAIKTADIISVHCPLTDETRDLITLNELK 218
Query: 255 QMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
M+P + ++NTARGG++++ LA AL+Q I A +DV EP
Sbjct: 219 MMKPSSIIINTARGGIINEADLATALEQNLIAGAGVDVLTKEP 261
>UniRef50_Q4PER7 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 413
Score = 121 bits (291), Expect = 5e-26
Identities = 105/291 (36%), Positives = 143/291 (49%), Gaps = 25/291 (8%)
Query: 27 SRPLVALLDG-RDCTVEMPILKDVATVAFCDAQSTSEIHEKVLN-----EAVGALMW--- 77
S+P V LLD + T E+ L VA V A++ E+ EK + + VG
Sbjct: 67 SKPKVLLLDQIKLATTELGQLSKVANVVESTAKTRQELIEKFQSGGEYAQVVGIYRHFGG 126
Query: 78 -HTIILT-KEDLEKFK----ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVAD 131
+I +T + D E LR IV G+G D +DV+A + GI NVP + +D
Sbjct: 127 ARSIKVTGRFDAELVSQLPSTLRYIVHNGAGYDQLDVQALSDKGIQASNVPTAVDDATSD 186
Query: 132 TTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA 191
+ L+L RR + A KF +A RG TLGIVG G IG A A
Sbjct: 187 VALYLLLGALRR-FPRAKAQMNAGKFNSAFSFLDARDP----RGKTLGIVGAGGIGRAFA 241
Query: 192 LRAK-AFGFNVIFYDP-YLPDGIEKSL---GLTRVYTLQDLLFQSDCVSLHCSLNEHNHH 246
+A A G VI+++ L +E G+ TL++LL QSD VSLHC L
Sbjct: 242 HKASHALGVKVIYHNRNQLSSDVESQAAKGGMKYAKTLEELLQQSDIVSLHCPLTPATKG 301
Query: 247 LINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
LI + ++ M+ A L+NTARG +V ++ LA AL+QG I A LDV E EP
Sbjct: 302 LIGKQQLEMMKKDAILINTARGPVVKEDELAEALEQGVIAGAGLDVFEAEP 352
>UniRef50_Q6LYW5 Cluster: 2-hydroxyacid dehydrogenase, D-isomer
specific; n=7; cellular organisms|Rep: 2-hydroxyacid
dehydrogenase, D-isomer specific - Methanococcus
maripaludis
Length = 318
Score = 121 bits (291), Expect = 5e-26
Identities = 75/252 (29%), Positives = 123/252 (48%), Gaps = 6/252 (2%)
Query: 46 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDN 105
LK + ++ D SE+ E++ + + ++ + +I+ KE LEK K ++ + +G +
Sbjct: 21 LKKLGELSIYDRTLESEVVERISDSEI--VITNKVIIGKEVLEKCKNIKYVGVTATGYNV 78
Query: 106 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 165
+D A + G+ V NVP Y + VA IL + V+ G + +
Sbjct: 79 VDTTLAKDHGVIVTNVPAYSTDSVAQLVFSFILEHCQNVSKYTESVKSGD-WVNSKDFSY 137
Query: 166 ASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQ 225
+ G +LGI+G G IG VA AFG NV+ + E ++ + +
Sbjct: 138 QKFPIIELAGKSLGIIGFGAIGKKVAEIGNAFGMNVLVNTRTVSKTDEINVNFV---SKE 194
Query: 226 DLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRI 285
++ SD ++LHC LN ++NE T+ M+ A L+NT RGGLV+++ LA AL +I
Sbjct: 195 EIFKNSDFLTLHCPLNNETDKIVNEKTLNLMKKSAILINTGRGGLVNEKDLANALNLEKI 254
Query: 286 RAAALDVHENEP 297
A LDV EP
Sbjct: 255 AGAGLDVLSTEP 266
>UniRef50_Q1DT79 Cluster: Putative uncharacterized protein; n=1;
Coccidioides immitis|Rep: Putative uncharacterized
protein - Coccidioides immitis
Length = 354
Score = 120 bits (290), Expect = 7e-26
Identities = 73/211 (34%), Positives = 110/211 (52%), Gaps = 8/211 (3%)
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
+L+II G + D + G GI CN G + D + LI+ +R T + N +
Sbjct: 88 SLKIISSSNHGYEREDTEELGRRGIWYCNGAGAANDSTGDIALLLIIAAFRYTSFCENNL 147
Query: 152 REGKK---FTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYL 208
R +K F + V S R LGIVG+G +G AV++RAKA G + ++
Sbjct: 148 RTTRKGDYFAVEDAVAPTSVNP---RDKILGIVGMGEVGRAVSVRAKALGMKIHYFSRTR 204
Query: 209 PDG-IEKSLGLTRVY-TLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
+E+ G+ + TL+ LL +DCV L C + HHL+N+ T K M+ G +VN A
Sbjct: 205 KSPKVEREAGVAEYHATLESLLKVADCVLLACPHSPETHHLLNKDTFKLMKRGVRVVNVA 264
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
RG +D+E LA A+ +G + A LDV+ +EP
Sbjct: 265 RGKCIDEEALADAIDEGIVVGAGLDVYHDEP 295
>UniRef50_Q0V2B9 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 336
Score = 120 bits (290), Expect = 7e-26
Identities = 82/253 (32%), Positives = 120/253 (47%), Gaps = 9/253 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
LRI+V G D+ V + G+ CN + AD + LI+ + R T +R
Sbjct: 89 LRIVVSAQRGFDDFHVDWMTKQGVLFCNTGHAMADSTADIALFLIMAVTRNTSRAEQSLR 148
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY-LPDG 211
G R+ +R TLGIVG G IGS +A +A A G +++Y+ P
Sbjct: 149 SGAWRGHLPLSRD-------LRSITLGIVGAGSIGSCLAQKAVALGMKLLYYNKSGKPMA 201
Query: 212 IEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
G TL +LL SD VSLHC LN+ HL+++ M+ G+++VNTARG ++
Sbjct: 202 NRFPTGSVHCATLDELLQTSDVVSLHCPLNQDTWHLMSDREFNLMKDGSYVVNTARGAVI 261
Query: 272 DDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSV-LLQQGP 330
D + L AL+ G++ A LDV ENEP + +L + S L +Q
Sbjct: 262 DSQALIRALESGKLAGAGLDVFENEPTGIDPYFLESDKVVPIPHMGGLTEGSFELAEQEC 321
Query: 331 LKDAPNLLCTPHA 343
L++ LCT A
Sbjct: 322 LRNVYECLCTATA 334
>UniRef50_A7HEG1 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase NAD-binding; n=4; Bacteria|Rep: D-isomer
specific 2-hydroxyacid dehydrogenase NAD-binding -
Anaeromyxobacter sp. Fw109-5
Length = 399
Score = 120 bits (289), Expect = 9e-26
Identities = 76/205 (37%), Positives = 109/205 (53%), Gaps = 7/205 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L ++VR G+GV+ IDV AA G+ V N PG VA+ + L++ L RR ++R
Sbjct: 63 LSLVVRAGAGVNTIDVAAASRRGVYVANCPGQNSIAVAELAIGLVVALDRRIPDNVALLR 122
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
GK + EA + G TLG+ G+G IG VA RA+A G V+ + L D
Sbjct: 123 AGK--WDKKTFSEAQG----LYGRTLGVAGVGSIGREVARRAQALGMRVVAWSRSLDDRQ 176
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
K LG+ R L L +SD +SLH +L++ +++ ++ +RPGA LVNTAR +VD
Sbjct: 177 AKLLGVERAPDLAALARESDFLSLHLALSKETRGIVSREVLEALRPGAALVNTARAEIVD 236
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
L + GR+R DV EP
Sbjct: 237 QAALLELARAGRLRVGT-DVFAGEP 260
>UniRef50_A4WXD4 Cluster: Dimethylmenaquinone methyltransferase;
n=1; Rhodobacter sphaeroides ATCC 17025|Rep:
Dimethylmenaquinone methyltransferase - Rhodobacter
sphaeroides ATCC 17025
Length = 334
Score = 120 bits (289), Expect = 9e-26
Identities = 80/226 (35%), Positives = 112/226 (49%), Gaps = 8/226 (3%)
Query: 72 VGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVAD 131
+ A+M +T E + L++IV+ G GVDNID+ AA GI V G VA+
Sbjct: 57 IDAMMVRQGRITDEVIGASPGLKVIVKHGVGVDNIDLAAAEARGIPVLRSMGSNSRAVAE 116
Query: 132 TTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA 191
+ L L L + L N +G + P + + +G LG+VG G IG A
Sbjct: 117 HAIALALMLVKEIQPL-NAAVKGGAWPKPTFIGKD------FQGAMLGLVGYGGIGRETA 169
Query: 192 LRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEF 251
A+A G V+ +DPY P+ E G L+ +L D +SLHC L LI+
Sbjct: 170 RMAEALGMEVVVHDPYAPEAAEAD-GFAAAADLEAMLPALDILSLHCPLTSATRDLIDAR 228
Query: 252 TIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ M+ A +VNTARGG++D+ LA AL+ G I AALD EP
Sbjct: 229 RLAMMKRTAVIVNTARGGIIDEAALADALRAGAIAGAALDSFATEP 274
>UniRef50_Q7D366 Cluster: AGR_pAT_578p; n=2; Agrobacterium
tumefaciens str. C58|Rep: AGR_pAT_578p - Agrobacterium
tumefaciens (strain C58 / ATCC 33970)
Length = 317
Score = 120 bits (288), Expect = 1e-25
Identities = 74/207 (35%), Positives = 110/207 (53%), Gaps = 14/207 (6%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L+ I R G GVDNID+ AA GIAV N PG VA+ T+ LIL+ RR +L + +R
Sbjct: 72 LKAIARFGVGVDNIDIDAAHRHGIAVTNAPGGNANAVAELTLGLILSAMRRIPYLHDALR 131
Query: 153 EGK--KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPD 210
G +F G E + G +G++G G I +A + F VI YD + PD
Sbjct: 132 GGAWDRFVGQELI-----------GRRVGLLGFGNIARKIARKLCGFDVEVIAYDKF-PD 179
Query: 211 GIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGL 270
+ + R+ + ++L SD + + L++ +M+PG+ +NTARG L
Sbjct: 180 QVAATKLGVRMCEMDEVLSSSDILVMMMPSLPETRRLMDAGRFARMKPGSIFINTARGAL 239
Query: 271 VDDEGLAAALKQGRIRAAALDVHENEP 297
VD++ L AL G ++AAA+DV+E EP
Sbjct: 240 VDEKALYDALVSGHLQAAAIDVYETEP 266
>UniRef50_A6LZ51 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Clostridium
beijerinckii NCIMB 8052|Rep: D-isomer specific
2-hydroxyacid dehydrogenase, NAD-binding - Clostridium
beijerinckii NCIMB 8052
Length = 320
Score = 120 bits (288), Expect = 1e-25
Identities = 70/205 (34%), Positives = 108/205 (52%), Gaps = 9/205 (4%)
Query: 96 IVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGK 155
+V+ G+G DN+D+ A + GI N G + VA+ M LIL+ Y+ +L + ++
Sbjct: 72 LVQTGAGFDNVDIDACTQYGIWAANAAGVNAQAVAEHVMALILSYYKNIPFLDSFIKN-- 129
Query: 156 KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKS 215
K E S ++G T+GI+G G +G VA + F N++ Y + + +S
Sbjct: 130 KIDENELQYTGS----ELKGKTIGIIGFGAVGKKVAEFCRVFDMNILVY---ARNPVVQS 182
Query: 216 LGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEG 275
++ L+ SD VS+H SLN+ LIN+ K+M+ A VNTARGG+V++
Sbjct: 183 DSFVKMTDFDTLVGASDIVSVHVSLNQQTKQLINKDVFKKMKNTALFVNTARGGIVNERD 242
Query: 276 LAAALKQGRIRAAALDVHENEPFNV 300
L ALK I A LDV E+EP +
Sbjct: 243 LIDALKNKDISGACLDVFESEPLPI 267
>UniRef50_A0JWH0 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=14; Bacteria|Rep: D-isomer
specific 2-hydroxyacid dehydrogenase, NAD-binding -
Arthrobacter sp. (strain FB24)
Length = 322
Score = 120 bits (288), Expect = 1e-25
Identities = 79/226 (34%), Positives = 120/226 (53%), Gaps = 11/226 (4%)
Query: 84 KEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRR 143
+E L K L+++V G +ID++AA ELGI VC G + T L+L L R
Sbjct: 63 RERLAKLPDLKLLVTTGMANQSIDLRAAEELGIVVCGTGG-SPTAAPELTWGLLLALARS 121
Query: 144 TYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIF 203
+ +REG+ +++ G + G TLG++GLG+IG VA +AFG +VI
Sbjct: 122 ISFEDRNLREGRW--------QSTVGF-ELAGKTLGVLGLGKIGRRVAAYGQAFGMDVIA 172
Query: 204 YDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLV 263
+ P L G+ +V + ++L SD VS+H L+E + ++ E ++ + P LV
Sbjct: 173 WSPNLTGEAAAQAGVRKV-SKEELFRDSDVVSVHVRLSERSRGVVGEEELRLLGPRGVLV 231
Query: 264 NTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHR 309
NT+RG LVD++ L AL +G I AALDV + EP L+ R
Sbjct: 232 NTSRGPLVDEDSLIRALNEGWIGGAALDVFDVEPLPAGHRLLSAPR 277
>UniRef50_A7P9P5 Cluster: Chromosome chr3 scaffold_8, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr3 scaffold_8, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 653
Score = 120 bits (288), Expect = 1e-25
Identities = 83/259 (32%), Positives = 128/259 (49%), Gaps = 16/259 (6%)
Query: 43 MPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKA----LRIIVR 98
+ +LKD A V S E+ K+ AL+ + TK E F+A L+++ R
Sbjct: 125 LDLLKDFANVDCAYNLSPEELCTKI--SLCDALIVRSG--TKVSREVFEASSGRLKVVGR 180
Query: 99 IGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFT 158
G G+DN+D+ AA E G V N P A+ + L+ + R V+ GK
Sbjct: 181 AGVGIDNVDLAAATEHGCLVVNAPTANTVAAAEHGIALLTAMARNVAQADASVKSGK--- 237
Query: 159 GPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGL 218
R G + + G TL ++G G++GS V RAK G +VI +DPY +++G+
Sbjct: 238 ---WQRNKYVGVSLV-GKTLAVMGFGKVGSEVTRRAKGLGMHVIAHDPYAAADRARAIGV 293
Query: 219 TRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAA 278
V + + +D +SLH L ++N+ T +M+ G ++N ARGG++D+E L
Sbjct: 294 ELV-GFDEAISTADFISLHMPLTPATSKMLNDETFAKMKKGVRIINVARGGVIDEEALVR 352
Query: 279 ALKQGRIRAAALDVHENEP 297
AL G + AALDV EP
Sbjct: 353 ALDAGIVAQAALDVFTEEP 371
>UniRef50_Q88VJ2 Cluster: D-lactate dehydrogenase; n=27;
Lactobacillales|Rep: D-lactate dehydrogenase -
Lactobacillus plantarum
Length = 332
Score = 120 bits (288), Expect = 1e-25
Identities = 81/265 (30%), Positives = 131/265 (49%), Gaps = 23/265 (8%)
Query: 102 GVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPE 161
GVDN+DV G+ + NVP Y +A+ ++ ++ L R+T + + P+
Sbjct: 79 GVDNLDVPTVKARGLNISNVPAYSPNAIAELSVTQLMQLLRQTPLFNKKLAKQDFRWAPD 138
Query: 162 QVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRV 221
+E + T+G++G GRIG A K FG VI YD Y +EK G+ V
Sbjct: 139 IAKELNTM-------TVGVIGTGRIGRAAIDIFKGFGAKVIGYDVYRNAELEKE-GMY-V 189
Query: 222 YTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALK 281
TL +L Q+D ++LH + N+H++N +M+ GA+++N ARG L+D E L AL
Sbjct: 190 DTLDELYAQADVITLHVPALKDNYHMLNADAFSKMKDGAYILNFARGTLIDSEDLIKALD 249
Query: 282 QGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCTP 341
G++ AALD +E E +F L G V + L + N+L TP
Sbjct: 250 SGKVAGAALDTYEYET-KIFNKDLEGQ----------TIDDKVFMN---LFNRDNVLITP 295
Query: 342 HAAFYSDASAQELREMAASEIRRAI 366
H AFY++ + + ++ + ++ I
Sbjct: 296 HTAFYTETAVHNMVHVSMNSNKQFI 320
>UniRef50_Q59516 Cluster: Glycerate dehydrogenase; n=23;
Proteobacteria|Rep: Glycerate dehydrogenase -
Methylobacterium extorquens (Protomonas extorquens)
Length = 314
Score = 120 bits (288), Expect = 1e-25
Identities = 78/235 (33%), Positives = 117/235 (49%), Gaps = 12/235 (5%)
Query: 65 EKVLNEAVGA--LMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVP 122
E+++ GA M + + + + L++ L++I +G D +D AA GI V N+
Sbjct: 36 EEIVERLQGAEIAMINKVPMRADTLKQLPDLKLIAVAATGTDVVDKAAAKAQGITVVNIR 95
Query: 123 GYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVG 182
Y V + + L+ L R AN VR G + +Q I G TLGI+G
Sbjct: 96 NYAFNTVPEHVVGLMFALRRAIVPYANSVRRGD-WNKSKQFCYFDYPIYDIAGSTLGIIG 154
Query: 183 LGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNE 242
G +G ++A RA+A G V+ +D + DG+ L+ +L QSD ++LH L
Sbjct: 155 YGALGKSIAKRAEALGMKVLAFDVFPQDGL---------VDLETILTQSDVITLHVPLTP 205
Query: 243 HNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++I +K+M+ A L+NTARGGLVD+ L ALK G I A DV EP
Sbjct: 206 DTKNMIGAEQLKKMKRSAILINTARGGLVDEAALLQALKDGTIGGAGFDVVAQEP 260
>UniRef50_Q89388 Cluster: A53R protein; n=3; Chlorovirus|Rep: A53R
protein - Paramecium bursaria Chlorella virus 1 (PBCV-1)
Length = 363
Score = 119 bits (287), Expect = 2e-25
Identities = 87/288 (30%), Positives = 140/288 (48%), Gaps = 13/288 (4%)
Query: 12 RMDSMRGPIANGPLQSRPLVALLDGRDCTVE-MPILKDVATVAFCDAQSTSEIHEKVLN- 69
+M S P P +P VA+ + + + ++ + T + ++ S +E + N
Sbjct: 13 KMFSRTSPKPVMPKNLKPQVAIFSAGNYVKDFIKPIESICTPVYIES-SLNETTAALANK 71
Query: 70 -EAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEE 128
+A+ A + + D+ K + I +G D +D++ A ELG V VP Y
Sbjct: 72 CDAINAFVNDDLSAPVLDILKNCGVSSITLRCAGFDRLDIEYAKELGFNVYRVPAYSPRS 131
Query: 129 VADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGS 188
VA+ + ++ L R + V+ G E G I T+GI+G G+I
Sbjct: 132 VAELALTHMMALSRNIQLVLPRVKTGN------YTMEGLVG-REITDKTIGIIGTGKIAQ 184
Query: 189 AVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLI 248
K +I YD Y D I K +G+ + +L D++ +SD +SLHC L + H+I
Sbjct: 185 EFIKLVKPMAGRIIAYDVYEND-IVKEMGVEYM-SLPDVIKESDVLSLHCPLMKSTFHMI 242
Query: 249 NEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
NE T+K M+ A ++NTARGGL+D E L AL+ G I A+DV+E+E
Sbjct: 243 NEDTLKTMKKTAVIINTARGGLIDTEALIDALESGVISGCAMDVYEHE 290
>UniRef50_Q30V14 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=3; Desulfovibrio|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase family
protein - Desulfovibrio desulfuricans (strain G20)
Length = 305
Score = 119 bits (287), Expect = 2e-25
Identities = 78/217 (35%), Positives = 120/217 (55%), Gaps = 15/217 (6%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
LT ++ L++I R G+G+DN+D++AA GIAV N P + VA+ T+ L L+L
Sbjct: 59 LTARVMDALPGLKVISRCGTGMDNVDMEAARARGIAVRNTPDGPTQAVAELTLGLALDLM 118
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R+ ++ M RE + +G + R + + G LGIVG+GRIG AVA G V
Sbjct: 119 RQ---VSRMDRELR--SGVWKKRMGNL----LGGKRLGIVGMGRIGRAVADIFTPLGVQV 169
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
F DP G +++LL +D +SLHCS+ L +++M+ G++
Sbjct: 170 AFNDPV------SCCGDYPCMPVEELLGWADILSLHCSMTGGECSLFTAEHLRRMKRGSW 223
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPF 298
++N ARGGL+D++ L AL G + AA+DV NEP+
Sbjct: 224 VINVARGGLIDEQALYEALADGHLAGAAVDVFGNEPY 260
>UniRef50_O83080 Cluster: D-lactate dehydrogenase; n=1; Treponema
pallidum|Rep: D-lactate dehydrogenase - Treponema
pallidum
Length = 331
Score = 119 bits (287), Expect = 2e-25
Identities = 81/262 (30%), Positives = 127/262 (48%), Gaps = 23/262 (8%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L+++ +G D + + GI + NVP Y + + + L L R + VR
Sbjct: 70 LKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVR 129
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
+ + F + + C+R+ GI+G GRIG A A K G V+ +DPY D
Sbjct: 130 K-RDFRWQKPILSKELRCSRV-----GILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAA 183
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
++ LT V ++ +LL SD +SLH + +HHLIN TI QM+ G +LVNTARG ++D
Sbjct: 184 KE--WLTYV-SMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVID 240
Query: 273 DEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLK 332
+ L +L +G+I AALD +E E + NG+ P L
Sbjct: 241 SQALLDSLDKGKIAGAALDAYEFE--GPYIPKDNGNNPITDTVYAR------------LV 286
Query: 333 DAPNLLCTPHAAFYSDASAQEL 354
++ TPH AFY++ + + +
Sbjct: 287 AHERIIYTPHIAFYTETAIENM 308
>UniRef50_UPI000023F60F Cluster: hypothetical protein FG08018.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG08018.1 - Gibberella zeae PH-1
Length = 901
Score = 119 bits (286), Expect = 2e-25
Identities = 77/243 (31%), Positives = 125/243 (51%), Gaps = 7/243 (2%)
Query: 56 DAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELG 115
DA +T + + L+ + LT +D+ L I + G G+D IDV A G
Sbjct: 42 DAITTDDPRHSRWRQEARYLLVRSSRLTAQDIISCPNLVAIGKQGVGLDKIDVDACASRG 101
Query: 116 IAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRG 175
I + N PG VA+ + L R+ + +++ K+ +G +E +G +
Sbjct: 102 IKIFNTPGVNARAVAELVLTLATASARQ---VGSII--AKQSSGILVPKEKCSGLI-LHE 155
Query: 176 DTLGIVGLGRIGSAVA-LRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCV 234
T+GI+G+G IG VA + AF NVI YDP+LP + + R +++++L SD +
Sbjct: 156 KTIGILGMGNIGKCVAKIFRGAFDANVIAYDPFLPADAWEEIPHKRATSVEEVLRSSDVI 215
Query: 235 SLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHE 294
++H L +LI +K+M+ A ++NTARGG+V+++ L AL +G I A LD H
Sbjct: 216 TVHMPLTPETRNLIGYDQMKKMKKTAIVINTARGGIVNEDDLKQALSEGLIWGAGLDCHT 275
Query: 295 NEP 297
EP
Sbjct: 276 EEP 278
>UniRef50_Q0HS14 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding protein; n=4; Shewanella|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding protein - Shewanella sp. (strain MR-7)
Length = 317
Score = 119 bits (286), Expect = 2e-25
Identities = 77/217 (35%), Positives = 112/217 (51%), Gaps = 7/217 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
L L + L+ I + +G + +D+ AA ELGI V NVP YG + VA IL+
Sbjct: 55 LDANTLAQLPKLKYIGVLATGTNVVDLAAAKELGIVVTNVPAYGPDAVAQMVFAHILHHT 114
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
+ V G+ ++ ++G TLG++G G IG VA A AFG V
Sbjct: 115 QAVAAHHQAVAAGQ-WSNCSDFCFTLMPLQSLKGKTLGLIGYGDIGQQVAKLALAFGMKV 173
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLF-QSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
+ P + + + +T +D +F +SD +SLHC LIN T++ M+P A
Sbjct: 174 LVNTRTKPSDLPQGVS----WTSRDTVFKESDILSLHCPFTPETTELINTQTLELMKPQA 229
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
L+NTARGGL+D+ LAAAL QG++ A +DV EP
Sbjct: 230 LLINTARGGLIDEAALAAALTQGKV-FAGVDVLSTEP 265
>UniRef50_Q04DF1 Cluster: Lactate dehydrogenase related enzyme; n=1;
Oenococcus oeni PSU-1|Rep: Lactate dehydrogenase related
enzyme - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 311
Score = 119 bits (286), Expect = 2e-25
Identities = 77/232 (33%), Positives = 123/232 (53%), Gaps = 12/232 (5%)
Query: 66 KVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYG 125
KV +A G ++ T + L KF L+II R G G DN+D K AGE G+ V P
Sbjct: 37 KVGKDADGIVLM-TDPFDNQTLTKFTNLKIIARHGVGFDNVDEKFAGEHGVYVTITPMAN 95
Query: 126 VEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGR 185
VA+TT+ IL+L + +++ +R+G + + + +G++G GR
Sbjct: 96 ASTVAETTIAEILDLSKNLTKISDEMRQGNFAYKLDHMG------FDLSHKKIGVMGYGR 149
Query: 186 IGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNH 245
IG VA +A A G +V+ +DP++ E +G ++ L+ QSD ++LH ++ +
Sbjct: 150 IGRQVAEKANALGMDVLIFDPFVK---ETKIG--KLVDRDTLISQSDVITLHLAVTDQTI 204
Query: 246 HLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
H + ++ M+ A L+N RG LVD++ L ALK +I AALDV + EP
Sbjct: 205 HGFGKRELEMMKKSASLINLGRGALVDEQALIDALKTKQINGAALDVFDEEP 256
>UniRef50_A6BZW2 Cluster: Putative dehydrogenase; n=1; Planctomyces
maris DSM 8797|Rep: Putative dehydrogenase -
Planctomyces maris DSM 8797
Length = 322
Score = 119 bits (286), Expect = 2e-25
Identities = 76/204 (37%), Positives = 108/204 (52%), Gaps = 10/204 (4%)
Query: 94 RIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVRE 153
+ I R+G G+DNIDV A L I V NVP Y + EVAD + L+L R +L +++
Sbjct: 72 KTIARLGIGLDNIDVAYATSLKIPVTNVPDYCIPEVADHAIGLMLASLRNIAFLNQQIKQ 131
Query: 154 GKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIE 213
G V R+ TLG+ G G G AVA RA+AFG VI + G +
Sbjct: 132 GIYDLSAAPVPR------RVGSLTLGLFGFGLTGQAVAERARAFGMQVIATNS---SGND 182
Query: 214 KSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDD 273
G TR+ ++LL +SD +S+H L + + + ++M+ A +VNTARG L+D
Sbjct: 183 YGTG-TRMVAFEELLEESDVISIHAPLTDATEYQFDAAAFQKMKSTAIIVNTARGALIDF 241
Query: 274 EGLAAALKQGRIRAAALDVHENEP 297
+ L A+K I AALDV + EP
Sbjct: 242 DALKTAVKNEDISGAALDVFDPEP 265
Score = 39.1 bits (87), Expect = 0.26
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 330 PLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRN 376
P ++ TPHAAF S S ELR+ AA ++ +VG+ P + N
Sbjct: 271 PFFQHDRIITTPHAAFISQESLDELRQQAACQVADVLVGKKPSNVVN 317
>UniRef50_Q0CUD5 Cluster: Putative uncharacterized protein; n=1;
Aspergillus terreus NIH2624|Rep: Putative
uncharacterized protein - Aspergillus terreus (strain
NIH 2624)
Length = 743
Score = 119 bits (286), Expect = 2e-25
Identities = 70/225 (31%), Positives = 117/225 (52%), Gaps = 8/225 (3%)
Query: 74 ALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTT 133
AL+ + LT ED+ L I + G G++ ID A + GI + N PG +VA+
Sbjct: 479 ALLIRSSYLTAEDIASCPNLVAIGKHGVGIEKIDQDACVKRGIKILNTPGANARDVAELV 538
Query: 134 MCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA-L 192
+ L L++ R + ++ + P V + + + T+GI+G+G IG VA +
Sbjct: 539 VTLALSVARGIRSITT-----RQMSKP--VPKETCNGLTLYQKTIGIIGMGNIGRTVAEI 591
Query: 193 RAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFT 252
F +++ YD Y PD I + + R ++ ++L ++D +S+H L + +I
Sbjct: 592 FRGGFAADIVAYDAYTPDNIWQHIPHVRARSIDEVLVRADVLSIHVPLTKDTRDMITYDR 651
Query: 253 IKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
I+ M+P A L+N ARGG+V++ L AL +G + A LD HE EP
Sbjct: 652 IRAMKPDAILINAARGGIVNERDLTRALSEGYLWGAGLDCHEQEP 696
>UniRef50_A0RUD3 Cluster: 2 lactate dehydrogenase; n=2;
Thermoprotei|Rep: 2 lactate dehydrogenase - Cenarchaeum
symbiosum
Length = 348
Score = 119 bits (286), Expect = 2e-25
Identities = 79/207 (38%), Positives = 110/207 (53%), Gaps = 14/207 (6%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L I G D+IDV A GI V P + AD TM L+L+L RR ++R
Sbjct: 102 LETIATYSVGYDHIDVAHARGRGITVGYTPDVLTDATADLTMALMLDLLRRVTEGDRIIR 161
Query: 153 EGK--KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPD 210
G+ + G + G G TLGI+G+GRIGS VA RA AFG VI++
Sbjct: 162 AGRWRQIYGADDYLGTDVG-----GKTLGILGMGRIGSRVAKRAAAFGMKVIYHS----- 211
Query: 211 GIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGL 270
S G TL LL +SD +S+H H +++ +++M+ A+L+NT+RG +
Sbjct: 212 --RSSTGPGTRVTLGRLLERSDVLSIHVPHTPDTHEMMDMSRLRKMKRSAYLINTSRGRV 269
Query: 271 VDDEGLAAALKQGRIRAAALDVHENEP 297
V ++ LAAAL+QG I AALDV +EP
Sbjct: 270 VHEKDLAAALRQGIIAGAALDVFHSEP 296
>UniRef50_Q8EP33 Cluster: Glycerate dehydrogenase; n=2;
Bacillaceae|Rep: Glycerate dehydrogenase -
Oceanobacillus iheyensis
Length = 314
Score = 118 bits (285), Expect = 3e-25
Identities = 79/226 (34%), Positives = 113/226 (50%), Gaps = 10/226 (4%)
Query: 72 VGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVAD 131
V ++ + + KE ++ L+ I++ G+G DNID K A E GI V N PG + VAD
Sbjct: 49 VEVIITAVVQIDKEIIDAAPNLKYIMKFGAGYDNIDFKYAREKGIPVTNTPGQNADAVAD 108
Query: 132 TTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA 191
+ L+L R +R G E S G I LGI+G G IG A+A
Sbjct: 109 LAIGLMLATARNIPAKNEELRNGNW--------ELSMGI-EIFQKKLGIIGFGAIGQAIA 159
Query: 192 LRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEF 251
RA F V+ Y + I L + V L LL +SD V + +L + N+ LIN
Sbjct: 160 QRATGFQMEVLAYGTFQDQTIADRLNVEFV-DLNKLLNESDIVVVSTTLRKDNYQLINAK 218
Query: 252 TIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
T+ +++ A +N +RG LVD++ L AL G+I+ A LDV EP
Sbjct: 219 TLNEIKKDALFINVSRGALVDEDALYEALTNGKIKGAGLDVFVEEP 264
>UniRef50_Q88YA7 Cluster: Bifunctional protein: amino acid
aminotransferase; 2-hydroxyacid dehydrogenase; n=2;
Lactobacillus|Rep: Bifunctional protein: amino acid
aminotransferase; 2-hydroxyacid dehydrogenase -
Lactobacillus plantarum
Length = 543
Score = 118 bits (285), Expect = 3e-25
Identities = 90/304 (29%), Positives = 136/304 (44%), Gaps = 24/304 (7%)
Query: 66 KVLNEAVGALMWHTIILTKEDLEKFKA-LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGY 124
K + +G + T+ T + + A L+ + +GVD ID+ AA G+ V NVP Y
Sbjct: 256 KAITAQLGKIHQFTVTSTTTNAQAAAAGLKQLTSRTAGVDTIDIPAAKAAGLVVTNVPAY 315
Query: 125 GVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLG 184
VA+ ++ + L R + + Q RE IR T+GI+G G
Sbjct: 316 SPNSVAEMSVAQTMRLIRNLEMFDQRISQQNFQWAGLQARE-------IRSLTVGIIGAG 368
Query: 185 RIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHN 244
RIG A G VI YD +E L T V T +DLL Q+D V LH LNE +
Sbjct: 369 RIGGTAARLFHGLGAKVIAYDVVRHPELEDVL--TYVDTKEDLLRQADVVDLHVDLNETS 426
Query: 245 HHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAY 304
LI+ +K M+ A+L+N +RG ++ + L AALK G I ALD E E A
Sbjct: 427 AGLIDAAALKLMKTDAYLINASRGPVIVTDDLVAALKAGEIAGCALDTVEGE-----NAL 481
Query: 305 LNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRR 364
N + L PN++ TPH FY++ + + + +++ ++
Sbjct: 482 FNQNHQGEVLQDT---------NVAQLMQMPNVIITPHVGFYTNLAVKNMVDISLDDVLA 532
Query: 365 AIVG 368
+ G
Sbjct: 533 ILNG 536
>UniRef50_Q73M93 Cluster: Glycerate dehydrogenase; n=3;
Bacteria|Rep: Glycerate dehydrogenase - Treponema
denticola
Length = 322
Score = 118 bits (285), Expect = 3e-25
Identities = 74/252 (29%), Positives = 125/252 (49%), Gaps = 5/252 (1%)
Query: 46 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDN 105
LK V+ + D S E+ E+ + A++ + ++ +KE ++ L+ I + +G +
Sbjct: 25 LKSVSNLTIYDKTSAEELLERC--KEADAVLTNKVVFSKEIMDSLPRLKYIGVLATGYNV 82
Query: 106 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 165
+D++AA I V N+P Y + VA LI + Y ++ V GK P
Sbjct: 83 VDIEAARAKNICVTNIPSYSTDSVAQLVFALIFHFYWHVKEHSDEVMGGKWSASPHFCYH 142
Query: 166 ASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQ 225
S + T+GIVG G IG AVA A A VI+++ + K L + +L
Sbjct: 143 -SFDIRELSDKTMGIVGFGNIGQAVAKIALAMNMKVIYFNRSKKN--IKGLEEAKQVSLD 199
Query: 226 DLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRI 285
+L SD +SL+C L +IN ++K+++ + ++NT RG L++++ A ALK+ R+
Sbjct: 200 ELFSSSDIISLNCPLTPETKEIINAESLKKIKKTSIVINTGRGPLINEKDAAEALKEKRL 259
Query: 286 RAAALDVHENEP 297
A DV EP
Sbjct: 260 AGLACDVLSVEP 271
>UniRef50_Q21A61 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Rhodopseudomonas
palustris BisB18|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding - Rhodopseudomonas palustris
(strain BisB18)
Length = 321
Score = 118 bits (285), Expect = 3e-25
Identities = 77/205 (37%), Positives = 103/205 (50%), Gaps = 8/205 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L+++ + G+G ++ID+ AA LG+ V G VA+ L+L L + VR
Sbjct: 70 LKVVAKHGAGTNDIDLAAAKALGVPVLAAVGANAHSVAEHAFMLMLALIKDVRNQDAYVR 129
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
G + RE +RG LG+VG+G IG A+A + G I YDP+ P
Sbjct: 130 GGGWDKKGYRGRE-------LRGRVLGLVGIGMIGRALAAMVQPIGMTTIAYDPFAP-AA 181
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
RV +L +LL QSD VSLHC L +LI M+P A L+NTARG +VD
Sbjct: 182 AFGPHARRVDSLDELLAQSDVVSLHCPLTPQTQNLIGVREFGLMKPSALLINTARGEVVD 241
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
+ L AL GRI AA LD EP
Sbjct: 242 EPALVGALTSGRIAAAGLDSFAVEP 266
>UniRef50_Q12CS0 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=8; Proteobacteria|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Polaromonas sp. (strain JS666 / ATCC
BAA-500)
Length = 335
Score = 118 bits (285), Expect = 3e-25
Identities = 82/221 (37%), Positives = 110/221 (49%), Gaps = 10/221 (4%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T L L++I + GVDN D+ A GI +C+ PG E ADT LI+
Sbjct: 64 ITASLLASAPQLKVISSVSVGVDNYDLPALAARGIMLCHTPGVLTETTADTIFSLIMASS 123
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
RR LA+ VREG+ + E G + G TLGI+G GRIG AVA RA A GFN+
Sbjct: 124 RRLVELASHVREGR---WTRNIGEDLFGWD-VHGKTLGILGFGRIGQAVARRA-ALGFNM 178
Query: 202 -IFYDPYLPDGIEKSL----GLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQM 256
+ Y P + L G +LL ++D V+ L++ L+ M
Sbjct: 179 PVLYHSRRPVDVAHELPELAGKATHTPFDELLQRADIVAAVLPLSKETRGLMGAREFDLM 238
Query: 257 RPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+PGA VN ARG +V ++ L AL G +RAA LDV EP
Sbjct: 239 KPGAIFVNGARGAIVQEDALLNALDHGTLRAAGLDVFATEP 279
>UniRef50_Q126V3 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=4; Proteobacteria|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Polaromonas sp. (strain JS666 / ATCC
BAA-500)
Length = 315
Score = 118 bits (285), Expect = 3e-25
Identities = 79/211 (37%), Positives = 110/211 (52%), Gaps = 10/211 (4%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
+ + AL +I +G G D +DV AA E I V + PG ++VAD + L+L++ RR
Sbjct: 61 MAQLPALEMISIMGVGYDGVDVTAALERNIRVTHTPGVLNDDVADLAIGLMLSVARRIPQ 120
Query: 147 LANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDP 206
VR G+ GP + ++ G+ LGIVGLGRIG A+A RA+AFG +V
Sbjct: 121 ADQYVRSGRWPEGPMPLAR------KVSGERLGIVGLGRIGQAIATRAEAFGMSVA---- 170
Query: 207 YLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTA 266
Y + L + Q L + D + L LIN +K + P +L+N A
Sbjct: 171 YTARSRKAELPYAYYPSAQALAAEVDFLVLITPGGAGTRKLINADVLKALGPQGYLINVA 230
Query: 267 RGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
RG +VD+ L AL+QG I AALDV ENEP
Sbjct: 231 RGSVVDEAALVEALQQGVIAGAALDVFENEP 261
>UniRef50_Q0K073 Cluster: D-3-Phosphoglycerate dehydrogenase; n=2;
Burkholderiales|Rep: D-3-Phosphoglycerate dehydrogenase
- Ralstonia eutropha (strain ATCC 17699 / H16 / DSM 428
/ Stanier 337)(Cupriavidus necator (strain ATCC 17699 /
H16 / DSM 428 / Stanier337))
Length = 360
Score = 118 bits (285), Expect = 3e-25
Identities = 76/198 (38%), Positives = 105/198 (53%), Gaps = 7/198 (3%)
Query: 100 GSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTG 159
GSG D ID+ A E G+AV N G + VA+ T+ L+L + RR +A R +
Sbjct: 92 GSGCDTIDIDACTEAGVAVLNQAGGNADSVAEMTLGLMLAVLRR---IAESDRSLRAHNC 148
Query: 160 PEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLT 219
+ RE G +RG TLG+VG+G G VA +A G VI DP L D E S
Sbjct: 149 --ESREDLMG-HELRGRTLGLVGVGHAGRRVAALGRALGMRVIGCDPAL-DAAELSARGA 204
Query: 220 RVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAA 279
+ + ++LL +D VSLHC + +++ MRPG+ V+TARGG+ D+ L AA
Sbjct: 205 QAVSFEELLRSADIVSLHCPRDATTLRMMDGAAFAAMRPGSIFVSTARGGIHDEGALHAA 264
Query: 280 LKQGRIRAAALDVHENEP 297
L G + A LDV + EP
Sbjct: 265 LASGHLAGAGLDVWDQEP 282
>UniRef50_A1IDH6 Cluster: D-3-phosphoglycerate dehydrogenase; n=3;
Deltaproteobacteria|Rep: D-3-phosphoglycerate
dehydrogenase - Candidatus Desulfococcus oleovorans Hxd3
Length = 532
Score = 118 bits (285), Expect = 3e-25
Identities = 72/205 (35%), Positives = 112/205 (54%), Gaps = 8/205 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L+ + R G G+DN+D+ AA + G+AV N P V A+ T+ +++ L R +R
Sbjct: 68 LKAVARAGIGLDNVDIPAATKHGVAVMNTPEGNVVTTAEHTIAMMMALTRNIPQGTLSLR 127
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
G+ Q RE + TLG++G G+IGS VA RA+ NVI +DP +
Sbjct: 128 SGQWEKKKLQGRE-------VFNKTLGVIGFGKIGSIVADRARQLKMNVIVFDPNIARTT 180
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
++ G V +L DL ++D +++H + L+N+ ++M+ G ++N ARGG+VD
Sbjct: 181 IENEGFEYV-SLDDLFARADYITVHVPKLKQTVGLLNKAAFEKMKTGVMVLNCARGGIVD 239
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
+ L AL GR+ AAALDV EP
Sbjct: 240 EADLYDALMSGRVAAAALDVFVTEP 264
>UniRef50_P58220 Cluster: 2-ketogluconate reductase; n=75;
Proteobacteria|Rep: 2-ketogluconate reductase -
Escherichia coli O157:H7
Length = 324
Score = 118 bits (285), Expect = 3e-25
Identities = 83/217 (38%), Positives = 107/217 (49%), Gaps = 10/217 (4%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
LEK LR I G DN DV A I + + P E VADT M L+L+ RR
Sbjct: 61 LEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRVVE 120
Query: 147 LANMVREGK--KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV-IF 203
+A V+ G+ GP+ + TLGIVG+GRIG A+A RA FGFN+ I
Sbjct: 121 VAERVKAGEWTASIGPDWYG------TDVHHKTLGIVGMGRIGMALAQRAH-FGFNMPIL 173
Query: 204 YDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLV 263
Y+ + R L LL +SD V L L + HHL +M+ A +
Sbjct: 174 YNARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFI 233
Query: 264 NTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNV 300
N RG +VD+ L AAL++G I AA LDV E EP +V
Sbjct: 234 NAGRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSV 270
>UniRef50_UPI0000384B5F Cluster: COG0111: Phosphoglycerate
dehydrogenase and related dehydrogenases; n=1;
Magnetospirillum magnetotacticum MS-1|Rep: COG0111:
Phosphoglycerate dehydrogenase and related
dehydrogenases - Magnetospirillum magnetotacticum MS-1
Length = 311
Score = 118 bits (284), Expect = 3e-25
Identities = 79/224 (35%), Positives = 117/224 (52%), Gaps = 9/224 (4%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+TK ++ L++I + G+G+D+ID A GI + VADT + IL+
Sbjct: 61 ITKTVIDAAANLKVISKWGTGIDSIDSAYAATKGIPTGRTLDAFTQPVADTALGYILSFA 120
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
R W+ M++ G + + G A + T+G+VG+G +GSAV RAK FG +
Sbjct: 121 RNLPWMDKMMKAG--------IWDKIPGRA-LNESTIGVVGVGCMGSAVLRRAKPFGARL 171
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ D D + + L LL QSD VS+ C LN ++ L N+ K+M+ G+
Sbjct: 172 LGNDIRTIDPAFVAEVGVEMMDLDSLLEQSDFVSVCCDLNPTSYLLFNDERFKRMKAGSV 231
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYL 305
LVNTARG +V +E L AL+ G+I ALDV E+EP A L
Sbjct: 232 LVNTARGPVVQEEALVRALQSGKIVGCALDVFEHEPLPKTSALL 275
>UniRef50_Q7M7Q8 Cluster: PUTATIVE D-2-HYDROXYACID DEHYDROGENASE;
n=2; Helicobacteraceae|Rep: PUTATIVE D-2-HYDROXYACID
DEHYDROGENASE - Wolinella succinogenes
Length = 312
Score = 118 bits (284), Expect = 3e-25
Identities = 75/239 (31%), Positives = 125/239 (52%), Gaps = 6/239 (2%)
Query: 59 STSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAV 118
+TS+ ++ L+ + ++L +E L + L++I +G++N+D+ A + GIAV
Sbjct: 30 TTSKEERLAHSQGQTILITNKVVLDEEILSQLPDLKLICISATGMNNVDLAYAKKRGIAV 89
Query: 119 CNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTL 178
NV GY VA T+ L+L L + + ++G P ++G
Sbjct: 90 KNVAGYSTSGVAQHTLLLVLALLGKLPYYHQYTQKGAWMESPI-FTHLDEEMHELKGKKW 148
Query: 179 GIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHC 238
GI+G+G IG VA A AFG ++ + + LT L+ +L +SD +++H
Sbjct: 149 GIIGMGAIGQRVAKLATAFGAIPSYHSTSGANTHQPYPALT----LEAILEESDILTIHA 204
Query: 239 SLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
LNE HHL+NE +K+++ GA L+N RGG+VD+E L+ + + R LDV E+EP
Sbjct: 205 PLNEKTHHLLNESRLKRVKRGAILINVGRGGIVDEEALSRLMLE-RNLWVGLDVLESEP 262
>UniRef50_A7IJ69 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase NAD-binding; n=2; Rhizobiales|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase
NAD-binding - Xanthobacter sp. (strain Py2)
Length = 359
Score = 118 bits (284), Expect = 3e-25
Identities = 82/215 (38%), Positives = 111/215 (51%), Gaps = 13/215 (6%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+T++ L L++I R G G D +DV AA +LG V G VAD T+ L+L +
Sbjct: 94 VTRDVLAAHPQLKVIARRGVGYDRVDVDAARDLGRVVTIAAGANDPAVADHTIALMLAVL 153
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
RR + G G A + G T+G++G GRIG VA R F V
Sbjct: 154 RRLKASQAAIARGDW--------RVLVG-ADLTGKTVGLIGFGRIGRQVARRLSGFDVTV 204
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
+ PD ++ G+T V L +L+ +SD VSLH L H+IN T+K M+ A
Sbjct: 205 LVTSR-TPD--PEAAGVTFV-ALDELIARSDVVSLHAPLVPETRHVINAATLKAMKRSAV 260
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
+VNT+RGGL+DD L AAL+ G I A LDV E E
Sbjct: 261 VVNTSRGGLIDDATLLAALEAGEIAGAGLDVFEAE 295
>UniRef50_A4TXP1 Cluster: Glycolate reductase; n=1; Magnetospirillum
gryphiswaldense|Rep: Glycolate reductase -
Magnetospirillum gryphiswaldense
Length = 330
Score = 118 bits (284), Expect = 3e-25
Identities = 79/208 (37%), Positives = 111/208 (53%), Gaps = 9/208 (4%)
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
++RII G +++D++AA GIA+ P E ADT M L+L RR + +
Sbjct: 80 SVRIICTYSVGTNHLDLQAARRHGIALAYAPEAVTEATADTAMLLLLAACRRAHEFQAQL 139
Query: 152 REGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDG 211
R+G+ G E + G G LG+VG+GRIG AVA RA+AFG ++ ++ +
Sbjct: 140 RQGR--WGAWNAWE-NLGWDP-GGQILGLVGMGRIGRAVARRARAFGMDIHYFQR---NR 192
Query: 212 IEKSL--GLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGG 269
+E SL G T +L L S VSLH IN + ++ GA +NTARG
Sbjct: 193 LESSLEDGATYHSSLDSLFAISRFVSLHTPTTPETKGFINAQALSWLKDGAIFINTARGD 252
Query: 270 LVDDEGLAAALKQGRIRAAALDVHENEP 297
VDD+ L AAL+ G++ AA LDV NEP
Sbjct: 253 QVDDDALIAALRSGKLAAAGLDVFNNEP 280
>UniRef50_Q0J5C2 Cluster: Os08g0447000 protein; n=11;
Viridiplantae|Rep: Os08g0447000 protein - Oryza sativa
subsp. japonica (Rice)
Length = 666
Score = 118 bits (284), Expect = 3e-25
Identities = 96/365 (26%), Positives = 165/365 (45%), Gaps = 19/365 (5%)
Query: 18 GPIANGPLQSRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMW 77
G +G L +P V + + + + +L+ A V S +E+ KV +
Sbjct: 67 GAGTDGALWPKPAVLVAE-KLSEAGLAVLRGFADVECAYGMSPAELLAKVAQFDALIVRS 125
Query: 78 HTIILTKEDLEKFKA-LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCL 136
T + T+E LE + LR++ R G G+DN+D++AA E G V N P A+ + L
Sbjct: 126 GTKV-TREVLEAGRGRLRVVGRAGVGIDNVDLQAATEAGCLVVNAPTANTVAAAEHGIAL 184
Query: 137 ILNLYRRTYWL-----ANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVA 191
+ ++ R A R FT + + + G TL ++G G++GS VA
Sbjct: 185 LASMARNVSQADAALKAVYSRTLTVFTAQGKWQRTKYVGVSLVGKTLAVMGFGKVGSEVA 244
Query: 192 LRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEF 251
RAK G +VI +DPY P +++G + + + + ++D +SLH L + N+
Sbjct: 245 RRAKGLGMHVIAHDPYAPADRARAIG-AELVSFDEAIGRADFISLHMPLTPATSKVFNDE 303
Query: 252 TIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNV-FQAYLNGHRP 310
+ +M+ G ++N ARGG++D++ L AL G++ + + + +Q +
Sbjct: 304 SFSRMKNGVRIINVARGGVIDEDALVRALDSGKVAQVICNFPYVIRYLLNYQCAIFLKVG 363
Query: 311 XXXXXXXXXXXCSVLLQQGPLKDA-----PNLLCTPHAAFYSDASAQELREMAASEIRRA 365
V ++ P KD+ N+ TPH AS E +E A EI A
Sbjct: 364 FLFLANVDQAALDVFTEEPPAKDSKLVLHENVTVTPHLG----ASTVEAQEGVAIEIAEA 419
Query: 366 IVGRI 370
+VG +
Sbjct: 420 VVGAL 424
>UniRef50_P53839 Cluster: Putative 2-hydroxyacid dehydrogenase
YNL274C; n=13; Saccharomycetales|Rep: Putative
2-hydroxyacid dehydrogenase YNL274C - Saccharomyces
cerevisiae (Baker's yeast)
Length = 350
Score = 118 bits (284), Expect = 3e-25
Identities = 78/205 (38%), Positives = 114/205 (55%), Gaps = 9/205 (4%)
Query: 96 IVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGK 155
+ G+G D IDV+ + I V NVP ADT + L+L R + + N R
Sbjct: 86 VCHTGAGYDQIDVEPFKKRHIQVANVPDLVSNATADTHVFLLLGALRN-FGIGN--RRLI 142
Query: 156 KFTGPEQVREASAGCARI-RGDTLGIVGLGRIGSAVALRAKAFGF-NVIFYDPY-LPDGI 212
+ PE + G T+GI+GLGRIG + R K FGF N I+++ + LP
Sbjct: 143 EGNWPEAGPACGSPFGYDPEGKTVGILGLGRIGRCILERLKPFGFENFIYHNRHQLPS-- 200
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
E+ G V ++ L +SD VS++ LN + HHLIN TI++M+ G +VNTARG ++D
Sbjct: 201 EEEHGCEYV-GFEEFLKRSDIVSVNVPLNHNTHHLINAETIEKMKDGVVIVNTARGAVID 259
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
++ + AL+ G+IR+A LDV E EP
Sbjct: 260 EQAMTDALRSGKIRSAGLDVFEYEP 284
>UniRef50_Q893I3 Cluster: D-lactate dehydrogenase; n=2;
Firmicutes|Rep: D-lactate dehydrogenase - Clostridium
tetani
Length = 327
Score = 118 bits (283), Expect = 5e-25
Identities = 89/277 (32%), Positives = 134/277 (48%), Gaps = 27/277 (9%)
Query: 84 KEDLEKFK--ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 141
+E LEK + + +G +NID++AA E I V N Y VAD L L L
Sbjct: 58 RETLEKLSKGGTKYLASRSTGYNNIDMEAAKEFRIKVSNAT-YSPNSVADFATMLALMLN 116
Query: 142 RRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNV 201
RR ++ K+ G + G + +G++G GRIG +V FG +
Sbjct: 117 RR------VIETLKRSVGNDYSLAGLMG-NELHNQVVGVIGTGRIGQSVVKNFSGFGCKI 169
Query: 202 IFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
I YD Y + ++K + + TL L ++D +++H L E N+HLIN+ TI +M+ G
Sbjct: 170 IAYDLYPNEEMKKYVEYVDLGTL---LSKADIITIHTPLFESNYHLINKETISKMKDGVK 226
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXX 321
++NTARG L++ L LK G+I AALDV ENE + N R
Sbjct: 227 IINTARGELINTFDLIEGLKSGKIGGAALDVIENE-LGILH---NDCRLKIINHDEFAI- 281
Query: 322 CSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMA 358
L++ PN++ TPH AFY+D + ++ E A
Sbjct: 282 ---------LRNLPNVILTPHLAFYTDQAVSDMVECA 309
>UniRef50_Q1FLB8 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, catalytic region:D- isomer specific
2-hydroxyacid dehydrogenase, NAD-binding; n=2;
Bacteria|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, catalytic region:D- isomer specific
2-hydroxyacid dehydrogenase, NAD-binding - Clostridium
phytofermentans ISDg
Length = 346
Score = 118 bits (283), Expect = 5e-25
Identities = 81/217 (37%), Positives = 116/217 (53%), Gaps = 15/217 (6%)
Query: 82 LTKEDLEKFKAL--RIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILN 139
+ KE +E+ L ++I +G +NID K A + IAV VPGY VA+ M L+L
Sbjct: 56 IDKETIEELYQLGIKVIAMRCAGYNNIDFKEAYQK-IAVVRVPGYSPHAVAEHAMALLLC 114
Query: 140 LYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGF 199
L R+ + R+ F+ + G + T+G+VG G+IG K FG
Sbjct: 115 LNRKIHRAYIRTRD-YNFS-----LKGLIGFDLYK-KTIGVVGTGKIGQVFIDICKGFGM 167
Query: 200 NVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPG 259
V+ YD Y PD K + +L+ L +SD +SLHC L E + H+IN T+K M+
Sbjct: 168 RVLAYDLY-PDH-SKDI---EYVSLETLFSESDVISLHCPLTEESKHMINAETLKLMKQD 222
Query: 260 AFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
A ++NT+RG L+D E L ALK+ RI A LDV+E E
Sbjct: 223 AVIINTSRGALIDSEALLVALKEERIAGAGLDVYEEE 259
>UniRef50_Q0B1Q1 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=5; Burkholderia|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase,
NAD-binding - Burkholderia cepacia (strain ATCC 53795 /
AMMD)
Length = 320
Score = 118 bits (283), Expect = 5e-25
Identities = 82/208 (39%), Positives = 105/208 (50%), Gaps = 11/208 (5%)
Query: 92 ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 151
+++II +G D++DV AA E GI V N P + AD TM L+L RR +V
Sbjct: 72 SVKIIANASAGYDHLDVAAARERGIVVSNAPDALTDCTADFTMLLMLAACRRASEYERIV 131
Query: 152 REG--KKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLP 209
R G K F + + R+ G TLGIVG GRIG AVA RA+ FG +++ D P
Sbjct: 132 RAGWGKSFGMTDMLG------TRVNGKTLGIVGFGRIGRAVAQRARGFGMKIVYTDRQ-P 184
Query: 210 DGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGG 269
E G L LL Q D V+LH + L+ MR GA VN ARG
Sbjct: 185 APPEVEAGARYCADLDTLLPQCDIVTLH--VPGGGTPLMTRRAFGLMRDGAVFVNAARGS 242
Query: 270 LVDDEGLAAALKQGRIRAAALDVHENEP 297
LVD++ L AL R+ A LDV+ NEP
Sbjct: 243 LVDEDALYDALTSRRLFGAGLDVYRNEP 270
>UniRef50_A3IA61 Cluster: D-3 phosphoglycerate dehydrogenase; n=1;
Bacillus sp. B14905|Rep: D-3 phosphoglycerate
dehydrogenase - Bacillus sp. B14905
Length = 319
Score = 118 bits (283), Expect = 5e-25
Identities = 73/213 (34%), Positives = 117/213 (54%), Gaps = 9/213 (4%)
Query: 85 EDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRT 144
E +++ L++I +GVD++ + A + VCN GY + VA+ T+ L+L++YR
Sbjct: 63 EVIDQNANLKLINVAFTGVDHVGIGQARNQDVMVCNAAGYANQAVAELTIGLVLDVYRH- 121
Query: 145 YWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFY 204
+ +G K + A G + I+G T+G++G G+IG A KAFG ++
Sbjct: 122 ------ITQGDKEIHADHFPGAFQG-SEIKGKTVGLIGTGKIGMMTARLFKAFGAKIVAS 174
Query: 205 DPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVN 264
D + + LG+ + L +LL QSD VSLH L LI++ ++ M+ A L+N
Sbjct: 175 DQSRRNPAAEVLGIEYM-ELDELLAQSDIVSLHIPLLSSTKGLISKEKLELMKGSAILIN 233
Query: 265 TARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
ARG +VD++ LA AL +GRI A +DV + EP
Sbjct: 234 CARGPIVDNDALADALNEGRIAGAGIDVFDMEP 266
>UniRef50_A0Q8P3 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase; n=3; Francisella tularensis subsp.
novicida|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase - Francisella tularensis subsp. novicida
(strain U112)
Length = 327
Score = 118 bits (283), Expect = 5e-25
Identities = 70/204 (34%), Positives = 109/204 (53%), Gaps = 8/204 (3%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
+R ++ +G +N+D+ A +L I V VP Y VA+ T+ L+L L R+ + N V+
Sbjct: 67 VRAVLLRCAGFNNVDIDHAKKLDIKVARVPAYSPFSVAEHTLALLLCLNRKIHKAYNRVK 126
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
E F E G + T+GI+G G IG A A FG ++ YDPY I
Sbjct: 127 ESN-FN-----IEGLEGFD-VHRKTIGIIGFGNIGKAFAQICSGFGGEILVYDPYADRAI 179
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
S +T V L ++D +SLHC LN ++I+E ++ ++P F++NT+RG L+D
Sbjct: 180 APSY-VTFVDDKNKLFAEADIISLHCPLNADTKYIIDEKALQIIKPSTFIINTSRGALID 238
Query: 273 DEGLAAALKQGRIRAAALDVHENE 296
+ + +LK I A A+DV+E E
Sbjct: 239 TQAIIKSLKSKSIAALAIDVYEYE 262
>UniRef50_A7SFV8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 487
Score = 118 bits (283), Expect = 5e-25
Identities = 78/216 (36%), Positives = 112/216 (51%), Gaps = 13/216 (6%)
Query: 85 EDLEKF-KALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRR 143
ED+ K K L+II R G+GVDNID AA G+ V N PG A+ T LI +L R
Sbjct: 61 EDVIKAGKNLKIIGRAGTGVDNIDTVAASLHGVLVMNTPGGNTLSAAEHTCALISSLARH 120
Query: 144 TYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIF 203
+ +EGK R+ G + G TL I+GLGRIG VALR +++G I
Sbjct: 121 IPQASASTKEGK------WERKQFMG-NELFGKTLAIIGLGRIGREVALRMQSYGVKTIG 173
Query: 204 YDPYLP--DGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAF 261
YDP + D E ++ + L +D +++H L ++N+ TI + G +
Sbjct: 174 YDPLVSPQDAAESNIEWMETEKIWPL---ADYITVHVPLIPPTKGMLNDKTIGMCKKGVY 230
Query: 262 LVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++N ARGG++D+E L L+ G + A LDV EP
Sbjct: 231 ILNVARGGIIDEEALLRGLESGHVGGAGLDVFVTEP 266
>UniRef50_Q8XN08 Cluster: D-lactate dehydrogenase; n=4;
Firmicutes|Rep: D-lactate dehydrogenase - Clostridium
perfringens
Length = 332
Score = 117 bits (282), Expect = 6e-25
Identities = 83/252 (32%), Positives = 127/252 (50%), Gaps = 17/252 (6%)
Query: 64 HEKVLNEAVGA---LMWHTIILTKEDLE--KFKALRIIVRIGSGVDNIDVKAAGELGIAV 118
HE V EA+GA ++ + +++LE K K L+ ++ G D++D+ AA +LG+ V
Sbjct: 37 HENV-EEAIGAEAIMVRGNCMADRQNLELLKSKGLKYVLTRTVGFDHVDLDAAKDLGLQV 95
Query: 119 CNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTL 178
VPGY + + + L + L R T + N K F V + IR T+
Sbjct: 96 ARVPGYSPNAIGELAVSLAMMLLRHTAYTTNRT-SNKNF-----VVDGFMFSKEIRNCTV 149
Query: 179 GIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHC 238
GI+G GRIG A K G V+ YD + D ++ + L ++L SD +S+H
Sbjct: 150 GILGAGRIGLTTAKLFKGLGAKVVAYDVFQSDAAKE---IVEFMPLDEVLKVSDVISVHM 206
Query: 239 S-LNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ N+H+INE I +M+ A ++NTARG L D E + AL++GR+ DV E E
Sbjct: 207 PYIKGQNYHMINEEFISKMKNDAIIINTARGELQDIEAIVKALEEGRLGGFGADVLEGES 266
Query: 298 FNVFQAYLNGHR 309
VF L G +
Sbjct: 267 -AVFFKNLEGQK 277
>UniRef50_Q6FFP8 Cluster: Putative 2-hydroxyacid dehydrogenase; n=2;
Acinetobacter sp. ADP1|Rep: Putative 2-hydroxyacid
dehydrogenase - Acinetobacter sp. (strain ADP1)
Length = 322
Score = 117 bits (282), Expect = 6e-25
Identities = 67/239 (28%), Positives = 124/239 (51%), Gaps = 8/239 (3%)
Query: 59 STSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAV 118
S +++ +V ++ V ++ +I+ ++ L+ L+++ +G ++++++ + + V
Sbjct: 38 SQDQLYHQVFDQDV--IIISDLIIDEQVLKNNPNLKLLALCSTGYNHVNIELLRQHNVQV 95
Query: 119 CNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTL 178
CN+ GY + VA+ L++ L + V++G TG A A ++G TL
Sbjct: 96 CNIRGYAGDAVAEHAFTLMIQLIKNFSQQVEGVKQGLWGTGQSSFYLA-APMRELKGKTL 154
Query: 179 GIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHC 238
I+G G IG ++A +A+AFG ++IF + + + + Q+D +SLHC
Sbjct: 155 TILGKGEIGESLAQKARAFGMHIIFSERKNASQCREGY-----VPFEQAIQQADILSLHC 209
Query: 239 SLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
LN+ HHLI+ + QM+P + L+N RGGLV D L AL ++ DV + EP
Sbjct: 210 ELNQSTHHLIDHSVLSQMKPESILINVGRGGLVKDSDLIEALLNHQLSGFGADVLDQEP 268
>UniRef50_A5ZAJ9 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 336
Score = 117 bits (282), Expect = 6e-25
Identities = 76/260 (29%), Positives = 131/260 (50%), Gaps = 11/260 (4%)
Query: 37 RDCTVEMPILK----DVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKA 92
RD +E + K + ++ + +E ++ + + G L + + KE +
Sbjct: 14 RDLEIEKSVFKKFLGEDTEISLYVHEGDNEKFKEAIKDVDGILTSY-LEFPKEIINSNPN 72
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L+ I +G + +D AA E G AV + Y +EVAD ++ L+L + R+ +
Sbjct: 73 LKGISIEATGYNFVDADAAQEQGTAVAVIGEYCTQEVADHSIALMLAVARKLKHYDREIE 132
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
+ +++G R+ G T GI+GLG+IG AVA RA+ FG NVI Y P +
Sbjct: 133 YKHVYD-----YNSTSGMIRLEGSTFGILGLGKIGKAVARRAQGFGMNVIAYSPSCKPEV 187
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
+SLG+ ++ + ++L SD +S+H L N +++N M+ +VN +RG ++D
Sbjct: 188 AESLGV-KLVSKEELFETSDVISVHMRLTPENENMLNREAFAMMKKKPIIVNVSRGSMID 246
Query: 273 DEGLAAALKQGRIRAAALDV 292
+E L AL G++ A LDV
Sbjct: 247 EEALLEALDNGQVFGAGLDV 266
>UniRef50_A4BI79 Cluster: D-lactate dehydrogenase; n=1; Reinekea sp.
MED297|Rep: D-lactate dehydrogenase - Reinekea sp.
MED297
Length = 320
Score = 117 bits (282), Expect = 6e-25
Identities = 76/225 (33%), Positives = 117/225 (52%), Gaps = 10/225 (4%)
Query: 75 LMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTM 134
++ + +++ ++ + + L++I +G +NID+ A + I V N YG VA+ T+
Sbjct: 47 IVTNKVVIDRDLISQLPQLKLIAVTATGTNNIDLDACRDHQIQVVNATDYGTHSVAEHTL 106
Query: 135 CLILNLYR--RTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVAL 192
L+L L R RTY AN E + ++ + + + + G L I+G G +GSAVA
Sbjct: 107 MLMLALSRQLRTYLEAN---ERRSWSQSPFFCDLLSPISTLHGKRLTILGRGTLGSAVAD 163
Query: 193 RAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFT 252
A A G +V F + D + + L +D VSLHC L + + LIN+ T
Sbjct: 164 LASALGMDVCFAEHRGADPVRPGY-----IAFESALRDADVVSLHCPLTDDTYQLINQET 218
Query: 253 IKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ M+P A L+NT RG LV++ L ALK G I AALDV EP
Sbjct: 219 LSWMKPTALLINTGRGDLVNETDLLHALKNGDIAGAALDVASVEP 263
>UniRef50_Q03XJ7 Cluster: 2-hydroxyacid dehydrogenase; n=3;
Lactobacillales|Rep: 2-hydroxyacid dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 319
Score = 117 bits (281), Expect = 8e-25
Identities = 82/272 (30%), Positives = 137/272 (50%), Gaps = 11/272 (4%)
Query: 31 VALLDGRDCTVEM--PILKDVATVAFCDAQST---SEIHEKVLNEAVGALMWHTIILTKE 85
+ LLDG + ++ LK++ F S +EI +++ + V ++ H L
Sbjct: 3 IVLLDGYNLNQDLNWETLKNLGDFEFYSRTSVDNDTEILQRIDDAEV--VITHKTPLDDS 60
Query: 86 DLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTY 145
+ + L+ I +G+G D +D+ +A I V NVP Y + VA T L+L + +
Sbjct: 61 VISRASQLKYIGIMGTGYDVVDIDSANNHNIIVTNVPTYATDAVAQFTFSLLLEITGQVG 120
Query: 146 WLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYD 205
+V +GK ++ + ++G TLG++G GRI VA A AF VIFY+
Sbjct: 121 LHNQLVHDGK-WSSVDDFTFWDKPLFELKGKTLGLIGYGRIAQKVAELANAFSMKVIFYN 179
Query: 206 PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNT 265
+ P + + +V +L +L ++D +SLH +LIN+ TI +M+ G L+NT
Sbjct: 180 -HRPS-VATQKWVNQV-SLDELFQKADIISLHVVQTPETINLINKTTISKMKDGVILINT 236
Query: 266 ARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
ARG L+ + +A AL ++ A A DV + EP
Sbjct: 237 ARGKLISENDIAEALNNEKVYALATDVVQKEP 268
>UniRef50_Q1E5G6 Cluster: Putative uncharacterized protein; n=1;
Coccidioides immitis|Rep: Putative uncharacterized
protein - Coccidioides immitis
Length = 527
Score = 117 bits (281), Expect = 8e-25
Identities = 83/205 (40%), Positives = 107/205 (52%), Gaps = 12/205 (5%)
Query: 101 SGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGK-KFTG 159
SG D +D+KAA GI V VP Y E + + T+ +++ L RRT VR G TG
Sbjct: 77 SGYDRVDIKAATANGITVTRVPAYSPEAIVEYTVGMLIALDRRTPHAWQRVRAGNFDLTG 136
Query: 160 PEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAK-AFGFNVIFYDPYLPDGIEKSLGL 218
G I G T+GIVG GRIG+ VA K F V+ D Y P+ + G+
Sbjct: 137 -------FVGHG-IHGKTVGIVGTGRIGAGVARVFKNGFQCEVLANDLY-PNATLEQHGV 187
Query: 219 TRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAA 278
R ++LL SD V LHC L H+I T+ M+ A LVNT+RG LV+ L
Sbjct: 188 -RYVEFKELLKSSDIVCLHCPLTTATRHIIKAETLAIMKQNAILVNTSRGALVNSSDLLH 246
Query: 279 ALKQGRIRAAALDVHENEPFNVFQA 303
AL++GRIR ALDV E E FQ+
Sbjct: 247 ALEKGRIRGCALDVVEGEEKYFFQS 271
>UniRef50_Q97IU7 Cluster: Lactate dehydrogenase; n=5;
Clostridiales|Rep: Lactate dehydrogenase - Clostridium
acetobutylicum
Length = 326
Score = 116 bits (280), Expect = 1e-24
Identities = 84/256 (32%), Positives = 130/256 (50%), Gaps = 27/256 (10%)
Query: 102 GVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLA-NMVREGKKFTGP 160
G D+ID+K A EL I V NV Y VAD T+ +IL R+ + N + G
Sbjct: 77 GYDHIDIKKAKELRIGVGNVT-YSPRSVADYTVMMILMATRKVKAIMQNSYVQDYSLEGI 135
Query: 161 EQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTR 220
Q +E + T+G++G G+IG V K F N+I YD + ++ +
Sbjct: 136 -QGKE-------LHNLTVGVIGTGKIGRTVIKNLKGFECNIIAYDINENEEVKAH---AK 184
Query: 221 VYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAAL 280
L++LL SD +++H E N+HLIN+ +I +M+ G F++NTARG +++ A+
Sbjct: 185 YVKLEELLMSSDVITVHVPGAEDNYHLINKNSISKMKDGVFIINTARGSIINTYDFIDAV 244
Query: 281 KQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXXXCSVLLQQGPLKDAPNLLCT 340
++G+I AALDV ENE N++ L G + LK PN++ T
Sbjct: 245 EKGKIGGAALDVIENET-NLYYKNLKGEVLGNR-------------ELAVLKSYPNVIIT 290
Query: 341 PHAAFYSDASAQELRE 356
PH AFY+D + ++ E
Sbjct: 291 PHTAFYTDQAVSDMVE 306
>UniRef50_A4FK85 Cluster: D-3-phosphoglycerate dehydrogenase,
putative; n=1; Saccharopolyspora erythraea NRRL
2338|Rep: D-3-phosphoglycerate dehydrogenase, putative -
Saccharopolyspora erythraea (strain NRRL 23338)
Length = 352
Score = 116 bits (280), Expect = 1e-24
Identities = 83/244 (34%), Positives = 123/244 (50%), Gaps = 6/244 (2%)
Query: 56 DAQSTSEIHEKVLNEAVGALMWHTII--LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGE 113
+ + S E++L G + T + T + L K LR + G N+D++AA E
Sbjct: 49 NVKEASGTEEQLLESLSGVQIAATQMAPFTADVLAKSPDLRFVGVCRGGPVNVDLQAATE 108
Query: 114 LGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARI 173
G+ V PG A+ + L+L RR ++ G + G E +AG +
Sbjct: 109 AGVVVSYAPGRNAAAAAEFAVGLVLAALRRIPASDAELKSGN-WRGDYYAYE-NAGI-EL 165
Query: 174 RGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDC 233
G T+G+VG G IG VA AFG +V+ DP++ + G+ V L++LL +S
Sbjct: 166 EGSTVGLVGYGAIGRIVARVLAAFGAHVLVADPFVKPEDATADGVELV-ELEELLRRSSV 224
Query: 234 VSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVH 293
VSLH L HHL+N + + GA LVN+ARGGL+D L LK GR+ A A+DV+
Sbjct: 225 VSLHARLTPETHHLLNADNLALLPEGAVLVNSARGGLLDYAPLPGLLKSGRLGALAVDVY 284
Query: 294 ENEP 297
+ EP
Sbjct: 285 DIEP 288
Score = 37.5 bits (83), Expect = 0.79
Identities = 17/47 (36%), Positives = 26/47 (55%)
Query: 330 PLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRN 376
PL DAPN++ TPH A + +A ++ A E+ R + G P + N
Sbjct: 294 PLFDAPNVITTPHLAGATRQTAHRAADIVAGEVARFLAGERPRFVAN 340
>UniRef50_A3RV54 Cluster: 2-hydroxyacid dehydrogenase; n=5;
Burkholderiales|Rep: 2-hydroxyacid dehydrogenase -
Ralstonia solanacearum UW551
Length = 331
Score = 116 bits (280), Expect = 1e-24
Identities = 80/215 (37%), Positives = 111/215 (51%), Gaps = 10/215 (4%)
Query: 87 LEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYW 146
L+ L+ + +G G +N+DV A G+ V N P + AD L+L RR
Sbjct: 62 LDACPGLKAVCNVGVGYNNVDVAACTARGVVVTNTPDVLTQTTADFGFALMLATARRITE 121
Query: 147 LANMVREGK-KFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAK-AFGFNVIFY 204
VR G+ + TG + G + I G TLGI+G+GRIG A+A RA F VI++
Sbjct: 122 SERFVRRGEWQKTG---IYNQMLG-SDIYGATLGILGMGRIGQAIARRAALGFEMQVIYH 177
Query: 205 D--PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFL 262
+ P P+ ++ R LL ++D + L + HH I + +M+P A L
Sbjct: 178 NRSPLTPE--TEARAHARYVDKDTLLREADHLILVLPYSPEAHHAIGAAELAKMKPTATL 235
Query: 263 VNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
N ARGG+VDDE LA AL+QG I AA LDV E EP
Sbjct: 236 TNIARGGIVDDEALAHALRQGTIAAAGLDVFEGEP 270
>UniRef50_UPI000023E18D Cluster: hypothetical protein FG04024.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG04024.1 - Gibberella zeae PH-1
Length = 357
Score = 116 bits (279), Expect = 1e-24
Identities = 77/205 (37%), Positives = 106/205 (51%), Gaps = 8/205 (3%)
Query: 94 RIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVRE 153
+II +G D++ + E GI +CN E AD L L + R TY +RE
Sbjct: 103 KIIASAAAGYDDLAEEWCTEQGIWLCNSVNAVAEATADMAFFLTLAVIRDTYRGERCLRE 162
Query: 154 GKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPY-LPDGI 212
G + GP G TLGIVGLG IG +A RA AF + +Y+ L
Sbjct: 163 GN-WRGPVVPSRDPWGM------TLGIVGLGAIGKCLAKRAVAFNMKIKYYNRRRLSAED 215
Query: 213 EKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVD 272
E+ T +L +LL QSD VS++C L + ++I+ + M+ GAF+VNTARG +VD
Sbjct: 216 EERYHATHCPSLNELLAQSDVVSINCPLTKETENMISTKEFETMKDGAFIVNTARGAIVD 275
Query: 273 DEGLAAALKQGRIRAAALDVHENEP 297
+ L AL+ G+I A LDV NEP
Sbjct: 276 ETALINALENGKITRAGLDVFLNEP 300
>UniRef50_Q97N23 Cluster: D-3-phosphoglycerate dehydrogenase; n=10;
Clostridiaceae|Rep: D-3-phosphoglycerate dehydrogenase -
Clostridium acetobutylicum
Length = 305
Score = 116 bits (279), Expect = 1e-24
Identities = 77/206 (37%), Positives = 109/206 (52%), Gaps = 11/206 (5%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L++I+R G GVDNIDV A + G+ V N P VA+ + + + R +R
Sbjct: 68 LKLIIRAGVGVDNIDVTYARDKGLTVNNTPNASSASVAELAIGHMFAVSRFINTANVTMR 127
Query: 153 EGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGI 212
+GK ++A G I G TLG++G GRI VA RA+A G VI+ D G
Sbjct: 128 QGK------WEKKAYTG-TEIFGKTLGLIGFGRIAREVAKRAEALGMKVIYNDIC---GK 177
Query: 213 EKSLGLTRVYT-LQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLV 271
Y + LL ++D VSLH ++ ++I + M+ GAFL+N ARGG+V
Sbjct: 178 VVGYDSYEFYDDINGLLREADFVSLHIPYDKKKGYVIGDNEFNAMKDGAFLINCARGGVV 237
Query: 272 DDEGLAAALKQGRIRAAALDVHENEP 297
++ L A+ G+IR AALDV ENEP
Sbjct: 238 SEQALLNAINNGKIRGAALDVFENEP 263
>UniRef50_Q1K3M3 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Desulfuromonas acetoxidans DSM 684|Rep:
D-3-phosphoglycerate dehydrogenase - Desulfuromonas
acetoxidans DSM 684
Length = 528
Score = 116 bits (279), Expect = 1e-24
Identities = 75/232 (32%), Positives = 118/232 (50%), Gaps = 8/232 (3%)
Query: 66 KVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYG 125
K++N ++ +++E + K L+II R G GV+NI + AA GI V N P
Sbjct: 38 KIINNYDALIVRGGTTVSEELIFAAKRLKIIARAGIGVENIAMDAANIKGIVVTNTPLGS 97
Query: 126 VEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGR 185
+A+ + ++++L R + +GK Q E + I TLG++G G+
Sbjct: 98 TTTIAEHAIAMMMSLARLIPQAHESMSQGKW-----QSTEFLG--SDINDKTLGVIGGGK 150
Query: 186 IGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNH 245
IG V A+ +V YDPYL + + LG ++V +L+DLL +D +SLH L
Sbjct: 151 IGRRVIEYARGLHMHVNLYDPYLSEEVITRLGASKV-SLEDLLSTADFISLHLPLTLETE 209
Query: 246 HLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
++N T ++PG L+N A GGL++++ L AL G AALD EP
Sbjct: 210 QILNAETFAMVKPGCRLINCALGGLINEDDLVNALTDGTFAGAALDTFATEP 261
>UniRef50_A5N5A9 Cluster: SerA; n=1; Clostridium kluyveri DSM
555|Rep: SerA - Clostridium kluyveri DSM 555
Length = 320
Score = 116 bits (279), Expect = 1e-24
Identities = 85/237 (35%), Positives = 127/237 (53%), Gaps = 13/237 (5%)
Query: 65 EKVLNEAV---GALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNV 121
E VL E V A++ +T++ + K L++I R G GV+N+D+K A EL I + N
Sbjct: 34 EDVLIEEVKDCDAILVRMANITEKVIRAGKKLKVISRFGVGVNNVDIKTASELSIQITNA 93
Query: 122 PGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIV 181
P VA+ TM LI+ L ++ + +R+G +VR+ + G LGIV
Sbjct: 94 PESNKNTVAEYTMGLIIALAKKFFLYDRGLRKGN-----FKVRDILG--IDLEGKVLGIV 146
Query: 182 GLGRIGSAVALRA-KAFGFNVIFYDPYLPDGIEKSLGLTRVY-TLQDLLFQSDCVSLHCS 239
GLG IG +AL+A K FG VI + ++ D KSL + +L +L SD VSL+
Sbjct: 147 GLGSIGKLLALKASKGFGMKVIGFKRHI-DEESKSLDYVELTDSLDYVLENSDFVSLNVP 205
Query: 240 LNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
L + +I + + M+ AFL+NTARG +VD++ L AL +I AA DV + E
Sbjct: 206 LTKATTKIIGKRELSFMKKDAFLINTARGEVVDNDALCNALLNKQIAGAATDVFDGE 262
>UniRef50_Q825H6 Cluster: Putative glycerate dehydrogenase; n=1;
Streptomyces avermitilis|Rep: Putative glycerate
dehydrogenase - Streptomyces avermitilis
Length = 325
Score = 116 bits (278), Expect = 2e-24
Identities = 76/219 (34%), Positives = 114/219 (52%), Gaps = 8/219 (3%)
Query: 82 LTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEE--VADTTMCLILN 139
+T E + L++I G D +D+ AA G+ VCN+ G E+ VA+ T L+L
Sbjct: 60 VTAEHIAAAPELQLIQCASHGFDYVDLDAARARGLPVCNIGSSGAEQQNVAEQTFALMLA 119
Query: 140 LYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGF 199
L ++ A+ + P R + + G TLGIVGLG IG VA RA AF
Sbjct: 120 LAKQLV-PAHTALVDADWALPRLQRSIT----ELSGKTLGIVGLGHIGEEVARRAVAFDM 174
Query: 200 NVIFYD-PYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRP 258
+++ + E LG R L +LL +D V+LH L E HL++ + ++P
Sbjct: 175 RIVYAGRERVGAEREARLGGARHVGLDELLRTADYVTLHAPLTEATRHLLDADRLALLKP 234
Query: 259 GAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
AF++NTARG L+D + LA AL++G + A +DV + EP
Sbjct: 235 TAFVINTARGALIDQDALADALEKGALAGAGIDVFDPEP 273
>UniRef50_Q0C254 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=2;
Alphaproteobacteria|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase family protein - Hyphomonas neptunium
(strain ATCC 15444)
Length = 337
Score = 116 bits (278), Expect = 2e-24
Identities = 79/232 (34%), Positives = 118/232 (50%), Gaps = 15/232 (6%)
Query: 67 VLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGV 126
+L A G ++ H I T+ E L +I R G G + +DV+AA +LG V G
Sbjct: 52 LLEGAGGWVVGHARI-TRAVFEALPDLAVISRRGVGYEKVDVEAARDLGRVVAIAAGGND 110
Query: 127 EEVADTTMCLILNLYRRTYWLANMVREGKK--FTGPEQVREASAGCARIRGDTLGIVGLG 184
VAD + +++++ RR + ++ GK G E R +GIVG G
Sbjct: 111 ASVADQVIGMMISIGRRFQEAQSAMKAGKWNILVGTELYRRK-----------VGIVGFG 159
Query: 185 RIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHN 244
RIG ++A R F ++ P L ++ GL V + LL ++D +S+H L
Sbjct: 160 RIGRSLARRLSGFEAEILVCAPRLASEDIETFGLRHV-AFETLLKEADYISVHAPLTPET 218
Query: 245 HHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENE 296
H+ N +M+P A L+N+ARGGLVDD L AAL+ G+I A LDV+E+E
Sbjct: 219 RHMFNAAAFGRMKPSAVLINSARGGLVDDTALLAALESGQILGAGLDVYESE 270
>UniRef50_A1HSQ7 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Thermosinus
carboxydivorans Nor1|Rep: D-isomer specific
2-hydroxyacid dehydrogenase, NAD-binding - Thermosinus
carboxydivorans Nor1
Length = 317
Score = 116 bits (278), Expect = 2e-24
Identities = 79/207 (38%), Positives = 109/207 (52%), Gaps = 14/207 (6%)
Query: 93 LRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVR 152
L+II + G G + IDV AA GI V PG VA+ + L+L + R + +VR
Sbjct: 71 LKIIAKHGVGYNTIDVAAAAAYGIPVTITPGANNISVAELAIGLMLAVARHIPQMDGIVR 130
Query: 153 EG--KKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPD 210
G + TG E + G LGI+G+G IG VA RA AFG +I YD
Sbjct: 131 RGGWSRMTGSE-----------LYGKVLGIIGMGSIGCEVAKRAHAFGMKIIAYDIRPRQ 179
Query: 211 GIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGL 270
+ ++ G+T + + D L Q+D +SLH +IN+ T+K M+ AFL+NTARG L
Sbjct: 180 DMIENYGVTYL-PMADCLAQADFLSLHAPALPETIGMINKDTLKTMKRTAFLINTARGDL 238
Query: 271 VDDEGLAAALKQGRIRAAALDVHENEP 297
+ +E L ALK G I A LD +EP
Sbjct: 239 IVEEDLYDALKNGVIAGAGLDTFVHEP 265
>UniRef50_Q8RG31 Cluster: 2-hydroxyglutarate dehydrogenase; n=4;
Bacteria|Rep: 2-hydroxyglutarate dehydrogenase -
Fusobacterium nucleatum subsp. nucleatum
Length = 338
Score = 115 bits (277), Expect = 2e-24
Identities = 82/283 (28%), Positives = 135/283 (47%), Gaps = 20/283 (7%)
Query: 83 TKEDLEKFK--ALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNL 140
TKE L+ +K ++ ++ G ++IDVK A ELG + VP Y +A+ + L ++L
Sbjct: 60 TKEVLDMYKEYGVKYLLTRTVGTNHIDVKYAKELGFKLAYVPFYSPNAIAELAVSLAMSL 119
Query: 141 YRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
R + A +KF +A +R T+G++GLGRIG A K G N
Sbjct: 120 LRHLPYTA------EKFKNRNFTVDAQMFSKEVRNCTVGVIGLGRIGFTAAKLFKGLGAN 173
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
VI YD + G+E + T+V + +L+ +SD ++LH + N ++ + + M+ +
Sbjct: 174 VIGYDMFPKTGVEDIV--TQV-PMDELIKKSDIITLHAPFIKENGKIVTKEFLNNMKENS 230
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQAYLNGHRPXXXXXXXXXX 320
L+NTARG L+D E + AL+ G + AA +D E E F+ +
Sbjct: 231 ILINTARGELMDLEAVIEALESGHLAAAGIDTIEGEVNYFFKNF---------SDKQAEF 281
Query: 321 XCSVLLQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIR 363
L L P +L TPH Y+D +A + E + ++
Sbjct: 282 RADYPLYNRLLDLYPRVLVTPHVGSYTDEAASNMIETSFENLK 324
>UniRef50_Q47W88 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase family protein; n=2; Alteromonadales|Rep:
D-isomer specific 2-hydroxyacid dehydrogenase family
protein - Colwellia psychrerythraea (strain 34H / ATCC
BAA-681) (Vibriopsychroerythus)
Length = 317
Score = 115 bits (277), Expect = 2e-24
Identities = 77/259 (29%), Positives = 132/259 (50%), Gaps = 9/259 (3%)
Query: 40 TVEMPILKDVATVAFCDAQ-STSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVR 98
T++ +++ + C A S +E+ ++ L+ + ++ + + LT E L +++I
Sbjct: 14 TIDFSVIEQQVSQLVCYANTSPNEVIKRCLDADI--IITNKVQLTAEMLSALPNVKLICI 71
Query: 99 IGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFT 158
+G +N+D++AA L IAV NV GY + VA +L Y++T + +G ++
Sbjct: 72 SATGYNNVDIEAARHLDIAVTNVSGYAGQSVAQYVFAQLLEYYQQTSHHNSNTEQGL-WS 130
Query: 159 GPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGL 218
+ + + G TLGI+G G +G AV A+AF V+ + P ++
Sbjct: 131 RNDTFCYHGNSISELAGKTLGIIGYGSLGKAVVDIAQAFNMKVLISER--PQA--STIRA 186
Query: 219 TRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAA 278
RV + + ++ ++D +SLHC + INE + +M+ A LVNTARG L+D+ L
Sbjct: 187 ERV-SFEQVIEEADIISLHCPQTPETENFINESVLARMKNTAVLVNTARGALIDEPALLD 245
Query: 279 ALKQGRIRAAALDVHENEP 297
ALK I A LDV EP
Sbjct: 246 ALKTKEIAYAILDVLSQEP 264
>UniRef50_A0VQR0 Cluster: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding; n=1; Dinoroseobacter shibae
DFL 12|Rep: D-isomer specific 2-hydroxyacid
dehydrogenase, NAD-binding - Dinoroseobacter shibae DFL
12
Length = 316
Score = 115 bits (277), Expect = 2e-24
Identities = 77/233 (33%), Positives = 114/233 (48%), Gaps = 7/233 (3%)
Query: 71 AVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVA 130
A G ++ + + + L+ LR+I +G+G+DNID+ A GI+V G VA
Sbjct: 45 ADGVIVRNRTQVDRPFLDAASRLRVIGLLGTGLDNIDMAACAARGISVHPATGANTRSVA 104
Query: 131 DTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAV 190
+ + L L RR + ++EG GP G I G LG+ G G + AV
Sbjct: 105 EYVITAALMLTRRAFMSTPEMQEGAWPRGP-----LGEG-GEIAGRKLGLYGCGAVAQAV 158
Query: 191 ALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINE 250
A AK ++ +DP+L G +TRV + LL ++D +SLH L I+
Sbjct: 159 ARLAKPLSMTILGHDPHLGPGHPLWTEVTRVSDAE-LLARADVLSLHLPLTPETRGRIDA 217
Query: 251 FTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQA 303
+ M+PGA L+NTA G +VD + AL++G + AALDV E EP A
Sbjct: 218 TALTAMKPGAILINTAHGEIVDARAVCDALRRGHLGGAALDVFEPEPLGTQDA 270
>UniRef50_Q8ZXX8 Cluster: D-3-phosphoglycerate dehydrogenase; n=1;
Pyrobaculum aerophilum|Rep: D-3-phosphoglycerate
dehydrogenase - Pyrobaculum aerophilum
Length = 323
Score = 115 bits (277), Expect = 2e-24
Identities = 74/217 (34%), Positives = 113/217 (52%), Gaps = 6/217 (2%)
Query: 81 ILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNL 140
++ KE L+ + L+I+ GVD+IDV+ A G+ V + P V+ VAD + L++ +
Sbjct: 62 VIDKEVLDAGEKLKIVSTASVGVDHIDVEYAKRKGVVVAHTPYVLVDAVADLAVGLLIAV 121
Query: 141 YRRTYWLANMVREGKKFTGPEQVREASAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFN 200
R+ ++R G + V + G +RG GIVGLG IG A+A R KAF
Sbjct: 122 TRKIALGDRLIRSG----AADAVWGSLMG-VNLRGKRAGIVGLGNIGVAIARRLKAFDIE 176
Query: 201 VIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGA 260
V ++ +E +LG+ + L LL SD + L +L N +++ GA
Sbjct: 177 VAYWSRRRKPEVEFALGIEYM-ELDSLLSSSDFIFLTMALTPETRWFFNRERFAKVKRGA 235
Query: 261 FLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEP 297
+ +N ARGGLVD + L AL+ G + AALDV + EP
Sbjct: 236 YFINVARGGLVDTDALIEALEAGVLAGAALDVFDVEP 272
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.322 0.137 0.410
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 443,408,550
Number of Sequences: 1657284
Number of extensions: 16459484
Number of successful extensions: 38567
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 831
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 36060
Number of HSP's gapped (non-prelim): 1334
length of query: 487
length of database: 575,637,011
effective HSP length: 104
effective length of query: 383
effective length of database: 403,279,475
effective search space: 154456038925
effective search space used: 154456038925
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 74 (33.9 bits)
- SilkBase 1999-2023 -