Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002307-TA|BGIBMGA002307-PA|IPR001128|Cytochrome P450
(458 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family... 179 2e-44
AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2 pro... 179 2e-44
AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens ... 179 2e-44
AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens ... 179 2e-44
BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family... 165 2e-40
U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein. 165 4e-40
S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxyl... 164 7e-40
AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4 omega-hy... 164 7e-40
D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4 omega-hydr... 163 1e-39
BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family... 163 1e-39
BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family... 163 1e-39
AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfam... 163 1e-39
AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein. 163 1e-39
S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxyl... 163 2e-39
L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein. 163 2e-39
D26481-1|BAA05491.1| 519|Homo sapiens fatty acids omega-hydroxy... 163 2e-39
AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family... 163 2e-39
AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family... 163 2e-39
AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfam... 161 5e-39
BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family... 161 6e-39
AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein. 161 6e-39
AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform... 161 6e-39
AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein. 161 6e-39
AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein. 161 6e-39
AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein. 161 6e-39
AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein. 160 1e-38
AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family... 159 2e-38
AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22 pr... 158 3e-38
AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K p... 158 4e-38
D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxyl... 157 1e-37
AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, famil... 156 1e-37
AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid omega-hydrox... 156 2e-37
D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV prot... 155 2e-37
BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family... 155 2e-37
BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family... 155 2e-37
BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family... 155 2e-37
AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens ... 155 2e-37
AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4 omega-hy... 155 2e-37
AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4 omega-hy... 155 2e-37
BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein. 152 3e-36
AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein. 151 4e-36
AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein. 149 2e-35
X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for ... 149 2e-35
J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung cyto... 149 2e-35
DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family... 149 2e-35
AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family... 149 2e-35
AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family... 149 2e-35
AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein. 149 2e-35
BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family... 149 3e-35
AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P4... 149 3e-35
AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family... 149 3e-35
AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family... 149 3e-35
AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein. 148 4e-35
AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein. 147 6e-35
AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein. 147 6e-35
AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family... 147 6e-35
AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family... 147 6e-35
AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein. 147 6e-35
BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein. 142 2e-33
AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family... 142 2e-33
AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P4... 140 7e-33
AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family... 140 7e-33
AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family... 140 7e-33
BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family... 139 2e-32
AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein. 139 2e-32
AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein. 139 2e-32
AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family... 139 2e-32
AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens ... 139 2e-32
AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens ... 139 2e-32
AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens ... 138 3e-32
AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, famil... 134 5e-31
J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3 prot... 118 6e-26
BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family... 118 6e-26
AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein. 118 6e-26
AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family... 116 2e-25
M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver glu... 115 3e-25
D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein. 115 3e-25
M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA... 113 9e-25
M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrom... 113 9e-25
DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family ... 113 9e-25
DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family... 113 9e-25
BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfam... 113 9e-25
BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family... 113 9e-25
AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein. 113 9e-25
AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein. 113 9e-25
AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450 polypep... 113 9e-25
AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4 p... 113 9e-25
X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for ... 113 1e-24
J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipin... 113 1e-24
AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4 pro... 110 1e-23
BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein. 108 3e-23
AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein. 108 3e-23
AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43... 107 6e-23
AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43... 107 8e-23
AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfami... 107 8e-23
AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43... 107 8e-23
AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfami... 107 8e-23
AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein. 107 8e-23
D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa pro... 106 1e-22
BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family... 106 1e-22
AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family... 106 1e-22
AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant... 106 1e-22
AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450 polypep... 106 1e-22
AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin D-1-... 106 1e-22
AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 106 1e-22
AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin ... 106 1e-22
AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 106 1e-22
AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 106 1e-22
AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 106 1e-22
AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 106 1e-22
AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 106 1e-22
BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family... 105 4e-22
AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxyl... 105 4e-22
AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfami... 103 2e-21
AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein. 103 2e-21
AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase pro... 100 2e-20
X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase... 99 3e-20
M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase pro... 99 3e-20
BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family... 99 3e-20
BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family... 99 3e-20
AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein. 99 4e-20
D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV prot... 98 7e-20
BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein. 95 5e-19
BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family... 90 2e-17
BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family... 90 2e-17
AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1 pro... 90 2e-17
U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450 monooxyge... 89 3e-17
BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family... 89 3e-17
AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family... 89 3e-17
AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein. 89 3e-17
AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2 pro... 89 4e-17
AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfami... 88 5e-17
AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase pr... 88 7e-17
AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase pr... 87 9e-17
M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase prot... 87 1e-16
D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase prot... 87 1e-16
BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase ... 87 1e-16
BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein. 87 1e-16
AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase ... 87 1e-16
AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase pr... 87 1e-16
AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase pr... 87 1e-16
AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase pr... 87 1e-16
AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase pr... 87 1e-16
AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase pr... 87 1e-16
AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase pr... 87 1e-16
AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase pr... 87 1e-16
AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase pr... 87 2e-16
AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase pr... 85 5e-16
AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens ... 84 9e-16
L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3 ... 84 1e-15
BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family... 84 1e-15
AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein. 84 1e-15
AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylas... 83 2e-15
AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family... 83 2e-15
AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family... 83 2e-15
S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D 24-hy... 82 3e-15
M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein. 80 1e-14
AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family... 80 1e-14
S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein. 80 2e-14
M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein. 80 2e-14
D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein. 80 2e-14
BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family... 80 2e-14
BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family... 80 2e-14
AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family... 80 2e-14
AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family... 80 2e-14
AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family... 80 2e-14
X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C pro... 79 2e-14
M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein. 79 2e-14
L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxyla... 79 2e-14
X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for ... 79 3e-14
M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid 1... 79 3e-14
M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein. 79 3e-14
L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein. 79 3e-14
BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family... 79 3e-14
BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein. 79 3e-14
AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family... 79 3e-14
AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family... 79 3e-14
AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family... 79 3e-14
AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome P-45... 79 3e-14
Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for ... 79 4e-14
X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for ... 79 4e-14
M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein. 79 4e-14
M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase... 79 4e-14
M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase... 79 4e-14
M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase... 79 4e-14
DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfami... 79 4e-14
BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein pr... 79 4e-14
BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein. 79 4e-14
BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family... 79 4e-14
BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family... 79 4e-14
BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family... 79 4e-14
AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family... 79 4e-14
AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family... 79 4e-14
X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein. 78 7e-14
X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase (P-... 78 7e-14
L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18 prot... 78 7e-14
D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase pr... 78 7e-14
X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein. 77 1e-13
M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc prot... 77 1e-13
M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein. 77 1e-13
BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family... 77 1e-13
BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family... 77 1e-13
M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatas... 77 1e-13
M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein. 77 1e-13
M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein. 77 1e-13
J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein. 77 1e-13
BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family... 77 1e-13
AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family... 77 2e-13
AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family... 77 2e-13
AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxyla... 77 2e-13
X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase ... 76 2e-13
DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6 pro... 76 2e-13
X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein. 76 3e-13
M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein. 76 3e-13
BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein. 76 3e-13
M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6 prot... 75 4e-13
M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoqu... 75 4e-13
M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein. 75 4e-13
DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 4e-13
DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 4e-13
DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6 pro... 75 4e-13
DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 4e-13
DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 4e-13
DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 4e-13
DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 4e-13
DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 4e-13
DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 4e-13
BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family... 75 4e-13
BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family... 75 4e-13
AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6 prot... 75 4e-13
AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein pr... 75 4e-13
AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein. 75 4e-13
AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxyl... 75 4e-13
X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein. 75 5e-13
AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 5e-13
AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 5e-13
M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant 21... 75 7e-13
M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human 21-hydrox... 75 7e-13
M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein. 75 7e-13
DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6 pro... 75 7e-13
DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 7e-13
DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 7e-13
DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 7e-13
DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 7e-13
DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 7e-13
DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 7e-13
DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 7e-13
CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein. 75 7e-13
BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family... 75 7e-13
BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family... 75 7e-13
BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family... 75 7e-13
BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family... 75 7e-13
BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family... 75 7e-13
BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family... 75 7e-13
BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family... 75 7e-13
BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family... 75 7e-13
BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein. 75 7e-13
AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 7e-13
AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,... 75 7e-13
AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family... 75 7e-13
AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family... 75 7e-13
AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, famil... 75 7e-13
AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, famil... 75 7e-13
AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, famil... 75 7e-13
AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, famil... 75 7e-13
AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P4... 75 7e-13
AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450 21-hydr... 75 7e-13
AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450 21-hydr... 75 7e-13
X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein. 74 9e-13
U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein. 74 9e-13
M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein. 74 9e-13
M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein. 74 9e-13
K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein. 74 9e-13
EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family... 74 9e-13
BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family... 74 9e-13
BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family... 74 9e-13
BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family... 74 9e-13
BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family... 74 9e-13
AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1 var... 74 9e-13
AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1 pro... 74 9e-13
AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,... 74 9e-13
AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family... 74 9e-13
AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein. 74 9e-13
AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein. 74 9e-13
Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for ... 74 1e-12
M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein. 74 1e-12
M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein. 74 1e-12
L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrom... 74 1e-12
DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family... 74 1e-12
BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family... 74 1e-12
BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family... 74 1e-12
BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family... 74 1e-12
BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family... 74 1e-12
BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family... 74 1e-12
AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,... 74 1e-12
AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,... 74 1e-12
AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein. 74 1e-12
M24667-1|AAA52148.1| 256|Homo sapiens steroid 11-beta-hydroxyla... 73 2e-12
BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family... 73 2e-12
AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,... 73 2e-12
AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2 pro... 73 2e-12
U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochro... 73 2e-12
BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family... 73 2e-12
AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family... 73 2e-12
AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1 ... 73 2e-12
X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mR... 73 3e-12
X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is ... 73 3e-12
M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein. 73 3e-12
BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family... 73 3e-12
BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family... 73 3e-12
BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family... 73 3e-12
BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family... 73 3e-12
AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase ... 73 3e-12
AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens ... 73 3e-12
AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6 pro... 73 3e-12
J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrom... 72 4e-12
J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrom... 72 4e-12
DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family... 72 4e-12
DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1 pro... 72 4e-12
AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family... 72 4e-12
AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family... 72 4e-12
AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens ... 72 4e-12
AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1 pro... 72 4e-12
AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1 pro... 72 4e-12
M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase pr... 72 5e-12
M12079-1|AAA52152.1| 191|Homo sapiens POR protein. 72 5e-12
AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family... 71 6e-12
X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for ... 71 9e-12
M12078-1|AAA52154.1| 192|Homo sapiens POR protein. 71 9e-12
Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein. 70 2e-11
M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein. 70 2e-11
M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein. 70 2e-11
M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein. 70 2e-11
M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein. 70 2e-11
M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein. 70 2e-11
M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrom... 70 2e-11
M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein. 70 2e-11
DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family... 70 2e-11
BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family... 70 2e-11
BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family... 70 2e-11
AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family... 70 2e-11
AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family... 70 2e-11
AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein. 70 2e-11
X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120... 69 3e-11
BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family... 69 3e-11
BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family... 69 3e-11
AY696295-1|AAU10524.1| 292|Homo sapiens cytochrome P450 protein. 69 3e-11
M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein. 69 3e-11
AL591242-1|CAH73899.1| 469|Homo sapiens cytochrome P450, family... 69 5e-11
AL035670-1|CAI20276.1| 469|Homo sapiens cytochrome P450, family... 69 5e-11
AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6 pro... 68 6e-11
BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family... 68 8e-11
BC010358-1|AAH10358.1| 469|Homo sapiens cytochrome P450, family... 68 8e-11
AF237982-1|AAF63329.1| 469|Homo sapiens oxysterol 7alpha-hydrox... 68 8e-11
U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase... 67 1e-10
D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase... 67 1e-10
AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein. 67 1e-10
AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13 va... 67 1e-10
AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13 va... 67 1e-10
AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13 va... 67 1e-10
AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13 va... 67 1e-10
AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13 pr... 67 1e-10
AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13 va... 66 2e-10
AY064484-1|AAL57719.1| 295|Homo sapiens truncated cytochrome P4... 66 2e-10
U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha demet... 66 2e-10
BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family... 66 2e-10
DQ016495-1|AAY34975.1| 195|Homo sapiens cytochrome P450 1B1 pro... 66 3e-10
U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein. 65 4e-10
M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein. 65 6e-10
J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein. 65 6e-10
BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family... 64 7e-10
AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein. 64 7e-10
AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens ... 64 7e-10
AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1 pro... 64 7e-10
U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein. 64 1e-09
L16883-1|AAD13467.1| 169|Homo sapiens cytochrome P-450 2C protein. 64 1e-09
AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1 pro... 64 1e-09
K03192-1|AAA52147.1| 331|Homo sapiens CYP1A1 protein. 63 2e-09
M80646-1|AAA60617.1| 460|Homo sapiens thromboxane synthase prot... 62 3e-09
BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein. 62 4e-09
U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein. 62 5e-09
AF221943-1|AAF86378.1| 175|Homo sapiens leukotriene B4 omega hy... 61 9e-09
BC022851-1|AAH22851.1| 215|Homo sapiens CYP4A11 protein protein. 60 1e-08
AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein. 60 1e-08
AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family... 58 6e-08
AM233517-1|CAJ80720.1| 175|Homo sapiens cytochrome P450 1A1 pro... 57 1e-07
BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family... 55 5e-07
BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family... 55 5e-07
AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoi... 55 5e-07
AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein. 55 5e-07
DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P4... 54 8e-07
AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens ... 51 1e-05
AK127151-1|BAC86855.1| 146|Homo sapiens protein ( Homo sapiens ... 50 2e-05
AY359068-1|AAQ89427.1| 462|Homo sapiens P450-like protein protein. 49 3e-05
S77409-1|AAB34643.1| 228|Homo sapiens steroid 18-hydroxylase pr... 49 4e-05
M17398-1|AAA35740.1| 393|Homo sapiens protein ( Human cytochrom... 49 4e-05
BC093022-1|AAH93022.1| 416|Homo sapiens CYP20A1 protein protein. 49 4e-05
BC033752-1|AAH33752.1| 462|Homo sapiens cytochrome P450, family... 49 4e-05
BC020616-1|AAH20616.1| 462|Homo sapiens cytochrome P450, family... 49 4e-05
L36085-1|AAC01761.1| 441|Homo sapiens thromboxane A2 synthase p... 48 9e-05
BC096286-1|AAH96286.1| 437|Homo sapiens cytochrome P450, family... 48 9e-05
AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family ... 48 9e-05
BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein. 47 1e-04
BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein. 47 1e-04
AL138805-2|CAM27343.1| 448|Homo sapiens cytochrome P450, family... 47 1e-04
BC128535-1|AAI28536.1| 143|Homo sapiens LOC283480 protein protein. 46 3e-04
AF183412-1|AAG09681.1| 435|Homo sapiens cytochrome P450 monooxy... 46 3e-04
X58904-1|CAA41707.1| 371|Homo sapiens steroid 21-monooxygenase ... 46 4e-04
X58902-1|CAA41706.1| 372|Homo sapiens steroid 21-monooxygenase ... 46 4e-04
X58900-1|CAA41704.1| 372|Homo sapiens steroid 21-monooxygenase ... 46 4e-04
X58899-1|CAA41703.1| 368|Homo sapiens steroid 21-monooxygenase ... 46 4e-04
AK094090-1|BAC04283.1| 153|Homo sapiens protein ( Homo sapiens ... 44 0.001
X58898-1|CAA41702.1| 371|Homo sapiens steroid 21-monooxygenase ... 44 0.001
AJ877238-1|CAI47002.1| 97|Homo sapiens putative cytochrome P45... 43 0.002
AY356349-1|AAQ55485.1| 522|Homo sapiens cytochrome P450 protein. 41 0.008
AL358613-1|CAH72802.2| 522|Homo sapiens cytochrome P450, family... 41 0.008
AC011737-1|AAX88915.1| 382|Homo sapiens unknown protein. 41 0.008
AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450 epoxyge... 40 0.014
AB209749-1|BAD92986.1| 210|Homo sapiens cytochrome P450, family... 40 0.014
M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein. 40 0.018
BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein. 40 0.018
AJ563379-2|CAD91649.1| 84|Homo sapiens cytochrome P450 protein. 38 0.098
BC001776-1|AAH01776.1| 217|Homo sapiens CYP27B1 protein protein. 32 3.7
AF280111-1|AAG33012.1| 250|Homo sapiens cytochrome P450 subfami... 31 6.4
X56088-1|CAA39568.1| 504|Homo sapiens cholesterol 7-alpha-hydr... 31 8.5
L29016-1|AAA36448.1| 386|Homo sapiens prostanoid IP receptor pr... 31 8.5
D38127-1|BAA07325.1| 386|Homo sapiens prostacyclin receptor pro... 31 8.5
D29634-1|BAA06110.1| 386|Homo sapiens prostacyclin receptor pro... 31 8.5
D25418-1|BAA05008.1| 386|Homo sapiens prostacyclin receptor pro... 31 8.5
BC110342-1|AAI10343.1| 386|Homo sapiens prostaglandin I2 (prost... 31 8.5
BC075814-1|AAH75814.1| 386|Homo sapiens prostaglandin I2 (prost... 31 8.5
AY242134-1|AAO92301.1| 386|Homo sapiens prostaglandin I2 (prost... 31 8.5
>BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family 4,
subfamily V, polypeptide 2 protein.
Length = 525
Score = 179 bits (436), Expect = 2e-44
Identities = 109/401 (27%), Positives = 193/401 (48%), Gaps = 8/401 (1%)
Query: 65 KHFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGN 124
K Y+F WLG GL+TS+G W+ RK+L P F+ IL F+ + N+++ LV ++
Sbjct: 120 KSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK 179
Query: 125 EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV-EDSDFNQKYIHSVDKLLSMLIYRFQNVLL 183
+ + A ++ TA G + S+ + +Y+ +V ++ M+ R + L
Sbjct: 180 HINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWL 239
Query: 184 HNSFIYKISGLKKKEEQIVETVHAMSNMII-KRKREASKNKSPTDEHCYDTTHRYKSIXX 242
Y + + ++ ++ +H +N +I +R E + N+ + + K
Sbjct: 240 WLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAF 299
Query: 243 XXXXXXXXXXX----XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEV 298
+IR+EVDT + G+DT++ + + LGS PE+Q KV E+
Sbjct: 300 LDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL 359
Query: 299 SSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNC 358
+FG S+ L Y+E V+KETLRL+P VP+ R D E+ Y + +
Sbjct: 360 DDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEA 419
Query: 359 VLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKT 418
V+ Y L+R P + P+ F+PER+ P A+ FS G R CIG+ +A+M KT
Sbjct: 420 VIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKT 479
Query: 419 TLVHLIRRYKVTADISKVEFKMD--VLMTPVNNCNVKFELR 457
L ++R + + ++ + E ++ +++ P N +K + R
Sbjct: 480 ILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
>AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2
protein.
Length = 525
Score = 179 bits (436), Expect = 2e-44
Identities = 109/401 (27%), Positives = 193/401 (48%), Gaps = 8/401 (1%)
Query: 65 KHFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGN 124
K Y+F WLG GL+TS+G W+ RK+L P F+ IL F+ + N+++ LV ++
Sbjct: 120 KSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK 179
Query: 125 EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV-EDSDFNQKYIHSVDKLLSMLIYRFQNVLL 183
+ + A ++ TA G + S+ + +Y+ +V ++ M+ R + L
Sbjct: 180 HINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWL 239
Query: 184 HNSFIYKISGLKKKEEQIVETVHAMSNMII-KRKREASKNKSPTDEHCYDTTHRYKSIXX 242
Y + + ++ ++ +H +N +I +R E + N+ + + K
Sbjct: 240 WLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAF 299
Query: 243 XXXXXXXXXXX----XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEV 298
+IR+EVDT + G+DT++ + + LGS PE+Q KV E+
Sbjct: 300 LDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL 359
Query: 299 SSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNC 358
+FG S+ L Y+E V+KETLRL+P VP+ R D E+ Y + +
Sbjct: 360 DDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEA 419
Query: 359 VLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKT 418
V+ Y L+R P + P+ F+PER+ P A+ FS G R CIG+ +A+M KT
Sbjct: 420 VIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKT 479
Query: 419 TLVHLIRRYKVTADISKVEFKMD--VLMTPVNNCNVKFELR 457
L ++R + + ++ + E ++ +++ P N +K + R
Sbjct: 480 ILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
>AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens
cDNA FLJ44509 fis, clone UTERU3001585, weakly similar
to Cytochrome P450 4c3 (EC 1.14.-.-). ).
Length = 503
Score = 179 bits (436), Expect = 2e-44
Identities = 109/401 (27%), Positives = 193/401 (48%), Gaps = 8/401 (1%)
Query: 65 KHFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGN 124
K Y+F WLG GL+TS+G W+ RK+L P F+ IL F+ + N+++ LV ++
Sbjct: 98 KSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK 157
Query: 125 EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV-EDSDFNQKYIHSVDKLLSMLIYRFQNVLL 183
+ + A ++ TA G + S+ + +Y+ +V ++ M+ R + L
Sbjct: 158 HINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWL 217
Query: 184 HNSFIYKISGLKKKEEQIVETVHAMSNMII-KRKREASKNKSPTDEHCYDTTHRYKSIXX 242
Y + + ++ ++ +H +N +I +R E + N+ + + K
Sbjct: 218 WLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAF 277
Query: 243 XXXXXXXXXXX----XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEV 298
+IR+EVDT + G+DT++ + + LGS PE+Q KV E+
Sbjct: 278 LDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL 337
Query: 299 SSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNC 358
+FG S+ L Y+E V+KETLRL+P VP+ R D E+ Y + +
Sbjct: 338 DDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEA 397
Query: 359 VLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKT 418
V+ Y L+R P + P+ F+PER+ P A+ FS G R CIG+ +A+M KT
Sbjct: 398 VIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKT 457
Query: 419 TLVHLIRRYKVTADISKVEFKMD--VLMTPVNNCNVKFELR 457
L ++R + + ++ + E ++ +++ P N +K + R
Sbjct: 458 ILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 498
>AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens
cDNA FLJ16007 fis, clone KIDNE2006580, weakly similar
to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
Length = 525
Score = 179 bits (436), Expect = 2e-44
Identities = 109/401 (27%), Positives = 193/401 (48%), Gaps = 8/401 (1%)
Query: 65 KHFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGN 124
K Y+F WLG GL+TS+G W+ RK+L P F+ IL F+ + N+++ LV ++
Sbjct: 120 KSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK 179
Query: 125 EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV-EDSDFNQKYIHSVDKLLSMLIYRFQNVLL 183
+ + A ++ TA G + S+ + +Y+ +V ++ M+ R + L
Sbjct: 180 HINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWL 239
Query: 184 HNSFIYKISGLKKKEEQIVETVHAMSNMII-KRKREASKNKSPTDEHCYDTTHRYKSIXX 242
Y + + ++ ++ +H +N +I +R E + N+ + + K
Sbjct: 240 WLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAF 299
Query: 243 XXXXXXXXXXX----XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEV 298
+IR+EVDT + G+DT++ + + LGS PE+Q KV E+
Sbjct: 300 LDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL 359
Query: 299 SSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNC 358
+FG S+ L Y+E V+KETLRL+P VP+ R D E+ Y + +
Sbjct: 360 DDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEA 419
Query: 359 VLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKT 418
V+ Y L+R P + P+ F+PER+ P A+ FS G R CIG+ +A+M KT
Sbjct: 420 VIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKT 479
Query: 419 TLVHLIRRYKVTADISKVEFKMD--VLMTPVNNCNVKFELR 457
L ++R + + ++ + E ++ +++ P N +K + R
Sbjct: 480 ILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
>BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 165 bits (402), Expect = 2e-40
Identities = 103/386 (26%), Positives = 187/386 (48%), Gaps = 10/386 (2%)
Query: 67 FAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEM 126
F Y F WLGDGL+ S+G+ W RHR++L PAF+ IL ++ +FND + ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNDSVNIMHAKWQLLA 182
Query: 127 AKGP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLH 184
++G +++ M L F + +YI ++ +L +++ R +LLH
Sbjct: 183 SEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLH 242
Query: 185 NSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIX 241
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 242 XXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSM 301
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 303 LLSKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 302 FGDSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCV 359
D E +++ L ++ +KE+LRL+P VP+ R DI L + IP C+
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 360 LGIYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKT 418
+ ++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK
Sbjct: 422 ISVFGTHHNPAMWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
Query: 419 TLVHLIRRYKVTADISKVEFKMDVLM 444
L + R++V D ++ K ++++
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVL 506
>U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein.
Length = 520
Score = 165 bits (400), Expect = 4e-40
Identities = 102/386 (26%), Positives = 188/386 (48%), Gaps = 10/386 (2%)
Query: 67 FAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEM 126
F Y F WLGDGL+ S+G+ W RHR++L PAF+ IL ++ +FN+ + ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182
Query: 127 AKGP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLH 184
++G +++ M L F + +YI ++ +L +++ R +LLH
Sbjct: 183 SEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLH 242
Query: 185 NSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIX 241
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 242 XXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSM 301
+IR E DT + G+DT++ VL+ V+ L +PE Q + QEV +
Sbjct: 303 LLSKDEDGKKLSDE-DIRAEADTFMFEGHDTTASVLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 302 FGDSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCV 359
D E +++ L ++ +KE+LR++P VP+ R DI L + IP C+
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRVHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 360 LGIYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKT 418
+ ++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK
Sbjct: 422 ISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
Query: 419 TLVHLIRRYKVTADISKVEFKMDVLM 444
L + R++V D ++ K ++++
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVL 506
>S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 519
Score = 164 bits (398), Expect = 7e-40
Identities = 104/397 (26%), Positives = 190/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNPEVFDPSRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNELKVATA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D +++ + L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRIPIPIARLVLKSKN-GIHLRLRR 508
>AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 164 bits (398), Expect = 7e-40
Identities = 102/386 (26%), Positives = 187/386 (48%), Gaps = 10/386 (2%)
Query: 67 FAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEM 126
F Y F WLGDGL+ S+G+ W RHR++L PAF+ IL ++ +FN+ + ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182
Query: 127 AKGP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLH 184
++G +++ M L F + +YI ++ +L +++ R +LLH
Sbjct: 183 SEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLH 242
Query: 185 NSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIX 241
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 242 XXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSM 301
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 303 LLSKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 302 FGDSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCV 359
D E +++ L ++ +KE+LRL+P VP+ R DI L + IP C+
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 360 LGIYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKT 418
+ ++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK
Sbjct: 422 ISVFGTHHNPAMWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
Query: 419 TLVHLIRRYKVTADISKVEFKMDVLM 444
L + R++V D ++ K ++++
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVL 506
>D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 163 bits (396), Expect = 1e-39
Identities = 102/386 (26%), Positives = 187/386 (48%), Gaps = 10/386 (2%)
Query: 67 FAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEM 126
F Y F WLGDGL+ S+G+ W RHR++L PAF+ IL ++ +FN+ + ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182
Query: 127 AKGP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLH 184
++G +++ M L F + +YI ++ +L +++ R +LLH
Sbjct: 183 SEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLH 242
Query: 185 NSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIX 241
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 242 XXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSM 301
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 303 LLSKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 302 FGDSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCV 359
D E +++ L ++ +KE+LRL+P VP+ R DI L + IP C+
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 360 LGIYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKT 418
+ ++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK
Sbjct: 422 ISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
Query: 419 TLVHLIRRYKVTADISKVEFKMDVLM 444
L + R++V D ++ K ++++
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVL 506
>BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 163 bits (396), Expect = 1e-39
Identities = 102/386 (26%), Positives = 187/386 (48%), Gaps = 10/386 (2%)
Query: 67 FAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEM 126
F Y F WLGDGL+ S+G+ W RHR++L PAF+ IL ++ +FN+ + ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182
Query: 127 AKGP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLH 184
++G +++ M L F + +YI ++ +L +++ R +LLH
Sbjct: 183 SEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLH 242
Query: 185 NSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIX 241
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 242 XXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSM 301
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 303 LLSKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 302 FGDSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCV 359
D E +++ L ++ +KE+LRL+P VP+ R DI L + IP C+
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 360 LGIYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKT 418
+ ++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK
Sbjct: 422 ISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
Query: 419 TLVHLIRRYKVTADISKVEFKMDVLM 444
L + R++V D ++ K ++++
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVL 506
>BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 163 bits (396), Expect = 1e-39
Identities = 102/386 (26%), Positives = 187/386 (48%), Gaps = 10/386 (2%)
Query: 67 FAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEM 126
F Y F WLGDGL+ S+G+ W RHR++L PAF+ IL ++ +FN+ + ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182
Query: 127 AKGP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLH 184
++G +++ M L F + +YI ++ +L +++ R +LLH
Sbjct: 183 SEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLH 242
Query: 185 NSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIX 241
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 242 XXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSM 301
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 303 LLSKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 302 FGDSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCV 359
D E +++ L ++ +KE+LRL+P VP+ R DI L + IP C+
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 360 LGIYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKT 418
+ ++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK
Sbjct: 422 ISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
Query: 419 TLVHLIRRYKVTADISKVEFKMDVLM 444
L + R++V D ++ K ++++
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVL 506
>AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfamily
IVF, polypeptide 2 protein.
Length = 520
Score = 163 bits (396), Expect = 1e-39
Identities = 102/386 (26%), Positives = 187/386 (48%), Gaps = 10/386 (2%)
Query: 67 FAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEM 126
F Y F WLGDGL+ S+G+ W RHR++L PAF+ IL ++ +FN+ + ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182
Query: 127 AKGP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLH 184
++G +++ M L F + +YI ++ +L +++ R +LLH
Sbjct: 183 SEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLH 242
Query: 185 NSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIX 241
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 242 XXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSM 301
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 303 LLSKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 302 FGDSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCV 359
D E +++ L ++ +KE+LRL+P VP+ R DI L + IP C+
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 360 LGIYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKT 418
+ ++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK
Sbjct: 422 ISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
Query: 419 TLVHLIRRYKVTADISKVEFKMDVLM 444
L + R++V D ++ K ++++
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVL 506
>AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein.
Length = 520
Score = 163 bits (396), Expect = 1e-39
Identities = 102/386 (26%), Positives = 187/386 (48%), Gaps = 10/386 (2%)
Query: 67 FAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEM 126
F Y F WLGDGL+ S+G+ W RHR++L PAF+ IL ++ +FN+ + ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182
Query: 127 AKGP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLH 184
++G +++ M L F + +YI ++ +L +++ R +LLH
Sbjct: 183 SEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLH 242
Query: 185 NSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIX 241
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 242 XXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSM 301
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 303 LLSKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 302 FGDSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCV 359
D E +++ L ++ +KE+LRL+P VP+ R DI L + IP C+
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 360 LGIYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKT 418
+ ++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK
Sbjct: 422 ISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480
Query: 419 TLVHLIRRYKVTADISKVEFKMDVLM 444
L + R++V D ++ K ++++
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVL 506
>S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 591
Score = 163 bits (395), Expect = 2e-39
Identities = 100/375 (26%), Positives = 182/375 (48%), Gaps = 8/375 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNPEVFDPSRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNELKVATA 472
Query: 422 HLIRRYKVTADISKV 436
+ R+++ D +++
Sbjct: 473 LTLLRFELLPDPTRI 487
>L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein.
Length = 519
Score = 163 bits (395), Expect = 2e-39
Identities = 104/397 (26%), Positives = 190/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNPEVFDPFRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNELKVATA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D +++ + L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRIPIPIARLVLKSKN-GIHLRLRR 508
>D26481-1|BAA05491.1| 519|Homo sapiens fatty acids
omega-hydroxylase protein.
Length = 519
Score = 163 bits (395), Expect = 2e-39
Identities = 104/397 (26%), Positives = 190/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNPEVFDPFRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNELKVATA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D +++ + L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRIPIPIARLVLKSKN-GIHLRLRR 508
>AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 163 bits (395), Expect = 2e-39
Identities = 104/397 (26%), Positives = 190/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNPEVFDPFRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNELKVATA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D +++ + L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRIPIPIARLVLKSKN-GIHLRLRR 508
>AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 163 bits (395), Expect = 2e-39
Identities = 104/397 (26%), Positives = 190/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNPEVFDPFRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNELKVATA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D +++ + L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRIPIPIARLVLKSKN-GIHLRLRR 508
>AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfamily
IVA, polypeptide 11 protein.
Length = 519
Score = 161 bits (391), Expect = 5e-39
Identities = 103/397 (25%), Positives = 190/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRL+P VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLFPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNPEVFDPFRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNELKVATA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D +++ + L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRIPIPIARLVLKSKN-GIHLRLRR 508
>BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 12 protein.
Length = 524
Score = 161 bits (390), Expect = 6e-39
Identities = 99/382 (25%), Positives = 182/382 (47%), Gaps = 8/382 (2%)
Query: 70 RFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
RF WLG+G++ S G+ W RHR++L PAF+ IL S+I +FN + ++ + + ++G
Sbjct: 126 RFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEG 185
Query: 130 P--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSF 187
+++ M L F + +YI ++ +L +++ R Q++L H F
Sbjct: 186 SSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDF 245
Query: 188 IYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXXX 244
+Y +S ++ + VH ++ +I+ +R + D + T + +
Sbjct: 246 LYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV-LLL 304
Query: 245 XXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD 304
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV + D
Sbjct: 305 SKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364
Query: 305 SE-ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+ +++ L ++ +KE+LRL+P P R DI L + IP C++ I
Sbjct: 365 RDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDI 424
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
G++ +P PD + P R+ P AF FS G R CIG+ +A+ MK L
Sbjct: 425 IGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484
Query: 423 LIRRYKVTADISKVEFKMDVLM 444
++ ++ D ++ K++++M
Sbjct: 485 MLLHFRFLPDHTEPRRKLELIM 506
>AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein.
Length = 524
Score = 161 bits (390), Expect = 6e-39
Identities = 99/382 (25%), Positives = 182/382 (47%), Gaps = 8/382 (2%)
Query: 70 RFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
RF WLG+G++ S G+ W RHR++L PAF+ IL S+I +FN + ++ + + ++G
Sbjct: 126 RFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEG 185
Query: 130 P--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSF 187
+++ M L F + +YI ++ +L +++ R Q++L H F
Sbjct: 186 SSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDF 245
Query: 188 IYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXXX 244
+Y +S ++ + VH ++ +I+ +R + D + T + +
Sbjct: 246 LYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV-LLL 304
Query: 245 XXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD 304
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV + D
Sbjct: 305 SKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364
Query: 305 SE-ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+ +++ L ++ +KE+LRL+P P R DI L + IP C++ I
Sbjct: 365 RDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDI 424
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
G++ +P PD + P R+ P AF FS G R CIG+ +A+ MK L
Sbjct: 425 IGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484
Query: 423 LIRRYKVTADISKVEFKMDVLM 444
++ ++ D ++ K++++M
Sbjct: 485 MLLHFRFLPDHTEPRRKLELIM 506
>AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform
4F12 protein.
Length = 524
Score = 161 bits (390), Expect = 6e-39
Identities = 99/382 (25%), Positives = 182/382 (47%), Gaps = 8/382 (2%)
Query: 70 RFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
RF WLG+G++ S G+ W RHR++L PAF+ IL S+I +FN + ++ + + ++G
Sbjct: 126 RFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEG 185
Query: 130 P--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSF 187
+++ M L F + +YI ++ +L +++ R Q++L H F
Sbjct: 186 SSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDF 245
Query: 188 IYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXXX 244
+Y +S ++ + VH ++ +I+ +R + D + T + +
Sbjct: 246 LYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV-LLL 304
Query: 245 XXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD 304
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV + D
Sbjct: 305 SKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364
Query: 305 SE-ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+ +++ L ++ +KE+LRL+P P R DI L + IP C++ I
Sbjct: 365 RDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDI 424
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
G++ +P PD + P R+ P AF FS G R CIG+ +A+ MK L
Sbjct: 425 IGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484
Query: 423 LIRRYKVTADISKVEFKMDVLM 444
++ ++ D ++ K++++M
Sbjct: 485 MLLHFRFLPDHTEPRRKLELIM 506
>AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein.
Length = 458
Score = 161 bits (390), Expect = 6e-39
Identities = 99/382 (25%), Positives = 182/382 (47%), Gaps = 8/382 (2%)
Query: 70 RFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
RF WLG+G++ S G+ W RHR++L PAF+ IL S+I +FN + ++ + + ++G
Sbjct: 60 RFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEG 119
Query: 130 P--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSF 187
+++ M L F + +YI ++ +L +++ R Q++L H F
Sbjct: 120 SSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDF 179
Query: 188 IYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXXX 244
+Y +S ++ + VH ++ +I+ +R + D + T + +
Sbjct: 180 LYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV-LLL 238
Query: 245 XXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD 304
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV + D
Sbjct: 239 SKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 298
Query: 305 SE-ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+ +++ L ++ +KE+LRL+P P R DI L + IP C++ I
Sbjct: 299 RDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDI 358
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
G++ +P PD + P R+ P AF FS G R CIG+ +A+ MK L
Sbjct: 359 IGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 418
Query: 423 LIRRYKVTADISKVEFKMDVLM 444
++ ++ D ++ K++++M
Sbjct: 419 MLLHFRFLPDHTEPRRKLELIM 440
>AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 161 bits (390), Expect = 6e-39
Identities = 99/382 (25%), Positives = 182/382 (47%), Gaps = 8/382 (2%)
Query: 70 RFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
RF WLG+G++ S G+ W RHR++L PAF+ IL S+I +FN + ++ + + ++G
Sbjct: 126 RFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEG 185
Query: 130 P--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSF 187
+++ M L F + +YI ++ +L +++ R Q++L H F
Sbjct: 186 SSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDF 245
Query: 188 IYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXXX 244
+Y +S ++ + VH ++ +I+ +R + D + T + +
Sbjct: 246 LYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV-LLL 304
Query: 245 XXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD 304
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV + D
Sbjct: 305 SKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364
Query: 305 SE-ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+ +++ L ++ +KE+LRL+P P R DI L + IP C++ I
Sbjct: 365 RDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDI 424
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
G++ +P PD + P R+ P AF FS G R CIG+ +A+ MK L
Sbjct: 425 IGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484
Query: 423 LIRRYKVTADISKVEFKMDVLM 444
++ ++ D ++ K++++M
Sbjct: 485 MLLHFRFLPDHTEPRRKLELIM 506
>AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 161 bits (390), Expect = 6e-39
Identities = 99/382 (25%), Positives = 182/382 (47%), Gaps = 8/382 (2%)
Query: 70 RFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
RF WLG+G++ S G+ W RHR++L PAF+ IL S+I +FN + ++ + + ++G
Sbjct: 126 RFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEG 185
Query: 130 P--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSF 187
+++ M L F + +YI ++ +L +++ R Q++L H F
Sbjct: 186 SSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDF 245
Query: 188 IYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXXX 244
+Y +S ++ + VH ++ +I+ +R + D + T + +
Sbjct: 246 LYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDV-LLL 304
Query: 245 XXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD 304
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV + D
Sbjct: 305 SKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364
Query: 305 SE-ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+ +++ L ++ +KE+LRL+P P R DI L + IP C++ I
Sbjct: 365 RDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDI 424
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
G++ +P PD + P R+ P AF FS G R CIG+ +A+ MK L
Sbjct: 425 IGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLAL 484
Query: 423 LIRRYKVTADISKVEFKMDVLM 444
++ ++ D ++ K++++M
Sbjct: 485 MLLHFRFLPDHTEPRRKLELIM 506
>AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein.
Length = 520
Score = 160 bits (388), Expect = 1e-38
Identities = 103/384 (26%), Positives = 186/384 (48%), Gaps = 10/384 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S+GE W RHR++L PAF+ IL ++ +FN+ + ++ +K
Sbjct: 125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASK 184
Query: 129 G--PVEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G +++ M L F + +YI ++ +L +++ R Q +LL+
Sbjct: 185 GYARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXX 243
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 245 FLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLL 304
Query: 244 XXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFG 303
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 305 SKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLK 363
Query: 304 DSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
D E +++ L ++ +KE+LRL+P VP R DI L + IP C++
Sbjct: 364 DREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLIS 423
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKTTL 420
++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK L
Sbjct: 424 VFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 421 VHLIRRYKVTADISKVEFKMDVLM 444
+ R++V D ++ K ++++
Sbjct: 483 GLTLLRFRVLPDHTEPRRKPELVL 506
>AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 3 protein.
Length = 520
Score = 159 bits (385), Expect = 2e-38
Identities = 102/384 (26%), Positives = 186/384 (48%), Gaps = 10/384 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S+GE W RHR++L PAF+ IL ++ +FN+ + ++ ++
Sbjct: 125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASE 184
Query: 129 GP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G +++ M L F + +YI ++ +L +++ R Q +LL+
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXX 243
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 245 FLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLL 304
Query: 244 XXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFG 303
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 305 SKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLK 363
Query: 304 DSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
D E +++ L ++ +KE+LRL+P VP R DI L + IP C++
Sbjct: 364 DREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLIS 423
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKTTL 420
++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK L
Sbjct: 424 VFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 421 VHLIRRYKVTADISKVEFKMDVLM 444
+ R++V D ++ K ++++
Sbjct: 483 GLTLLRFRVLPDHTEPRRKPELVL 506
>AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22
protein.
Length = 519
Score = 158 bits (384), Expect = 3e-38
Identities = 101/397 (25%), Positives = 187/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +Y+F + W+G L+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYKFLAPWIGYSLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+E M + +AF ++ +Q YI ++ L S++ R +N
Sbjct: 177 LGQDSPLEFFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLSSLVFCRMRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A E H
Sbjct: 237 HENDAIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQTEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ +
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNPEVFDPSRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNQLKVARA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D +++ M L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRIPIPMARLVLKSKN-GIHLRLRR 508
>AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K
protein.
Length = 519
Score = 158 bits (383), Expect = 4e-38
Identities = 102/397 (25%), Positives = 188/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +Y+F + W+G L+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYKFLAPWIGYSLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+E M + +AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEFFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNPEVFDPFRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNQLKVARA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D ++ M L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRTPIPMARLVLKSKN-GIHLRLRR 508
>D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 521
Score = 157 bits (380), Expect = 1e-37
Identities = 104/398 (26%), Positives = 189/398 (47%), Gaps = 9/398 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H + + + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLSHQHTRPKVIQLRKAQLQKEGELEKIKRKRHLDFLDIL 296
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 297 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 356
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 357 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 415
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 416 IYGLHHNPKVWPNPEVFDPFRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNELKVGQQ 473
Query: 422 HL-IRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
L + R+++ D +++ + L+ N + LR+
Sbjct: 474 ALTLVRFELLPDPTRIPIPIARLVLKSKN-GIHLRLRR 510
>AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 519
Score = 156 bits (379), Expect = 1e-37
Identities = 102/397 (25%), Positives = 188/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +Y+F + +G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + +AF ++ +Q YI ++ L S++ +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HENDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ +
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNLEVFDPSRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNQLKVARA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D +++ M L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRIPIPMARLVLKSKN-GIHLRLRR 508
>AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid
omega-hydroxylase CYP4A11 protein.
Length = 519
Score = 156 bits (378), Expect = 2e-37
Identities = 102/397 (25%), Positives = 188/397 (47%), Gaps = 9/397 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + +G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + +AF ++ +Q YI ++ L S++ +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HENDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ +
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
IYGL+ +P P+ F P R+ PG +AF FS G R CIGK +A+ +K
Sbjct: 415 IYGLHHNPKVWPNLEVFDPSRF-APGSA-QHSHAFLPFSGGSRNCIGKQFAMNQLKVARA 472
Query: 422 HLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK 458
+ R+++ D +++ + L+ N + LR+
Sbjct: 473 LTLLRFELLPDPTRIPIPIARLVLKSKN-GIHLRLRR 508
>D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV
protein.
Length = 520
Score = 155 bits (377), Expect = 2e-37
Identities = 101/384 (26%), Positives = 185/384 (48%), Gaps = 10/384 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S+GE W RHR++L PAF+ IL ++ +FN+ + ++ ++
Sbjct: 125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASE 184
Query: 129 GP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G +++ M L F + +YI ++ +L +++ R Q +LL+
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXX 243
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 245 FLYYLTPDGQRFRRACRLVHDFTDDVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLL 304
Query: 244 XXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFG 303
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 305 SKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLK 363
Query: 304 DSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
D E +++ L ++ +KE+LRL+P VP R DI L + IP C++
Sbjct: 364 DREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLIS 423
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKTTL 420
++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK L
Sbjct: 424 VFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 421 VHLIRRYKVTADISKVEFKMDVLM 444
+ ++V D ++ K ++++
Sbjct: 483 GLTLLAFRVLPDHTEPRRKPELVL 506
>BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 155 bits (377), Expect = 2e-37
Identities = 106/394 (26%), Positives = 183/394 (46%), Gaps = 8/394 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S G+ W RHR+LL PAF+ IL ++ +FN +S ++ +A+
Sbjct: 133 YGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFN-QSADIMHAKWRHLAE 191
Query: 129 GPVEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQK---YIHSVDKLLSMLIYRFQNVLLHN 185
G F ++ L + +S+ +K YI ++ +L ++ + R + +
Sbjct: 192 GSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYL 251
Query: 186 SFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXX 245
FIY S ++ Q + VH + +I+ +R A + + I
Sbjct: 252 DFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLL 311
Query: 246 XXXXXXXXXXXE-IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSS-MFG 303
E IR E DT + G+DT+S ++ ++ L YPE Q K +E+ M G
Sbjct: 312 ARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKG 371
Query: 304 DSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+++ L + +KE+LR YP V + RQ DI+L + IP C++ I
Sbjct: 372 RELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSI 431
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
YG + +P PD+ + P R+ P A+ FS G R CIG+ +A+ ++ +
Sbjct: 432 YGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVAL 491
Query: 423 LIRRYKVTAD-ISKVEFKMDVLMTPVNNCNVKFE 455
+ R++++ D KV K ++++ N +K E
Sbjct: 492 TLLRFRLSVDRTRKVRRKPELILRTENGLWLKVE 525
>BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 155 bits (377), Expect = 2e-37
Identities = 106/394 (26%), Positives = 183/394 (46%), Gaps = 8/394 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S G+ W RHR+LL PAF+ IL ++ +FN +S ++ +A+
Sbjct: 133 YGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFN-QSADIMHAKWRHLAE 191
Query: 129 GPVEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQK---YIHSVDKLLSMLIYRFQNVLLHN 185
G F ++ L + +S+ +K YI ++ +L ++ + R + +
Sbjct: 192 GSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYL 251
Query: 186 SFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXX 245
FIY S ++ Q + VH + +I+ +R A + + I
Sbjct: 252 DFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLL 311
Query: 246 XXXXXXXXXXXE-IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSS-MFG 303
E IR E DT + G+DT+S ++ ++ L YPE Q K +E+ M G
Sbjct: 312 ARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKG 371
Query: 304 DSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+++ L + +KE+LR YP V + RQ DI+L + IP C++ I
Sbjct: 372 RELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSI 431
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
YG + +P PD+ + P R+ P A+ FS G R CIG+ +A+ ++ +
Sbjct: 432 YGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVAL 491
Query: 423 LIRRYKVTAD-ISKVEFKMDVLMTPVNNCNVKFE 455
+ R++++ D KV K ++++ N +K E
Sbjct: 492 TLLRFRLSVDRTRKVRRKPELILRTENGLWLKVE 525
>BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 155 bits (377), Expect = 2e-37
Identities = 106/394 (26%), Positives = 183/394 (46%), Gaps = 8/394 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S G+ W RHR+LL PAF+ IL ++ +FN +S ++ +A+
Sbjct: 133 YGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFN-QSADIMHAKWRHLAE 191
Query: 129 GPVEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQK---YIHSVDKLLSMLIYRFQNVLLHN 185
G F ++ L + +S+ +K YI ++ +L ++ + R + +
Sbjct: 192 GSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYL 251
Query: 186 SFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXX 245
FIY S ++ Q + VH + +I+ +R A + + I
Sbjct: 252 DFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLL 311
Query: 246 XXXXXXXXXXXE-IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSS-MFG 303
E IR E DT + G+DT+S ++ ++ L YPE Q K +E+ M G
Sbjct: 312 ARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKG 371
Query: 304 DSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+++ L + +KE+LR YP V + RQ DI+L + IP C++ I
Sbjct: 372 RELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSI 431
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
YG + +P PD+ + P R+ P A+ FS G R CIG+ +A+ ++ +
Sbjct: 432 YGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVAL 491
Query: 423 LIRRYKVTAD-ISKVEFKMDVLMTPVNNCNVKFE 455
+ R++++ D KV K ++++ N +K E
Sbjct: 492 TLLRFRLSVDRTRKVRRKPELILRTENGLWLKVE 525
>AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens
cDNA FLJ39501 fis, clone PROST2016980, moderately
similar to CYTOCHROME P450 4F2 (EC 1.14.13.30). ).
Length = 531
Score = 155 bits (377), Expect = 2e-37
Identities = 106/394 (26%), Positives = 183/394 (46%), Gaps = 8/394 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S G+ W RHR+LL PAF+ IL ++ +FN +S ++ +A+
Sbjct: 133 YGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFN-QSADIMHAKWRHLAE 191
Query: 129 GPVEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQK---YIHSVDKLLSMLIYRFQNVLLHN 185
G F ++ L + +S+ +K YI ++ +L ++ + R + +
Sbjct: 192 GSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYL 251
Query: 186 SFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXX 245
FIY S ++ Q + VH + +I+ +R A + + I
Sbjct: 252 DFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRRQGAEAWLKAKQGKTLDFIDVLLL 311
Query: 246 XXXXXXXXXXXE-IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSS-MFG 303
E IR E DT + G+DT+S ++ ++ L YPE Q K +E+ M G
Sbjct: 312 ARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKG 371
Query: 304 DSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGI 362
+++ L + +KE+LR YP V + RQ DI+L + IP C++ I
Sbjct: 372 RELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSI 431
Query: 363 YGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVH 422
YG + +P PD+ + P R+ P A+ FS G R CIG+ +A+ ++ +
Sbjct: 432 YGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVAL 491
Query: 423 LIRRYKVTAD-ISKVEFKMDVLMTPVNNCNVKFE 455
+ R++++ D KV K ++++ N +K E
Sbjct: 492 TLLRFRLSVDRTRKVRRKPELILRTENGLWLKVE 525
>AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 155 bits (377), Expect = 2e-37
Identities = 101/384 (26%), Positives = 185/384 (48%), Gaps = 10/384 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S+GE W RHR++L PAF+ IL ++ +FN+ + ++ ++
Sbjct: 125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASE 184
Query: 129 GP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G +++ M L F + +YI ++ +L +++ R Q +LL+
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXX 243
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 245 FLYYLTPDGQRFRRACRLVHDFTDDVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLL 304
Query: 244 XXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFG 303
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 305 SKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLK 363
Query: 304 DSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
D E +++ L ++ +KE+LRL+P VP R DI L + IP C++
Sbjct: 364 DREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLIS 423
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKTTL 420
++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK L
Sbjct: 424 VFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 421 VHLIRRYKVTADISKVEFKMDVLM 444
+ ++V D ++ K ++++
Sbjct: 483 GLTLLAFRVLPDHTEPRRKPELVL 506
>AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 155 bits (377), Expect = 2e-37
Identities = 101/384 (26%), Positives = 185/384 (48%), Gaps = 10/384 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S+GE W RHR++L PAF+ IL ++ +FN+ + ++ ++
Sbjct: 125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASE 184
Query: 129 GP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G +++ M L F + +YI ++ +L +++ R Q +LL+
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXX 243
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 245 FLYYLTPDGQRFRRACRLVHDFTDDVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLL 304
Query: 244 XXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFG 303
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 305 SKDEDGKKLSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLK 363
Query: 304 DSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
D E +++ L ++ +KE+LRL+P VP R DI L + IP C++
Sbjct: 364 DREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLIS 423
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPD-DPNAFAGFSVGKRTCIGKVYALMSMKTTL 420
++G + +P PD + P R+ +P + + P AF FS G R CIG+ +A+ MK L
Sbjct: 424 VFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 421 VHLIRRYKVTADISKVEFKMDVLM 444
+ ++V D ++ K ++++
Sbjct: 483 GLTLLAFRVLPDHTEPRRKPELVL 506
>BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein.
Length = 524
Score = 152 bits (368), Expect = 3e-36
Identities = 98/383 (25%), Positives = 176/383 (45%), Gaps = 8/383 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S G+ W RHR++L PAF+ IL ++ +FN + + ++
Sbjct: 125 YGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASE 184
Query: 129 GP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G +++ M L F + +YI ++ +L + + R Q +LLH
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTD 244
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXX 243
F+Y ++ ++ + VH ++ +I+ +R + D T + +
Sbjct: 245 FLYYLTPDGQRFRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLLL 304
Query: 244 XXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFG 303
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 305 SKDEDGKELSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLK 363
Query: 304 DSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
D E +++ L ++ +KE+LRL+P VP+ R D L + IP C++
Sbjct: 364 DREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLIN 423
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
I G++ +P PD + P R+ + P AF FS G R CIG+ +A+ MK L
Sbjct: 424 IIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLA 483
Query: 422 HLIRRYKVTADISKVEFKMDVLM 444
+ +++ ++ K ++++
Sbjct: 484 LTLLHFRILPTHTEPRRKPELIL 506
>AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein.
Length = 524
Score = 151 bits (367), Expect = 4e-36
Identities = 97/368 (26%), Positives = 169/368 (45%), Gaps = 8/368 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S G+ W RHR++L PAF+ IL ++ +FN + + ++
Sbjct: 125 YGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASE 184
Query: 129 GP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G +++ M L F + +YI ++ +L + + R Q +LLH
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTD 244
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXX 243
F+Y ++ ++ + VH ++ +I+ +R + D T + +
Sbjct: 245 FLYYLTPDGQRFRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLLL 304
Query: 244 XXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFG 303
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 305 SKDEDGKELSDE-DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLK 363
Query: 304 DSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
D E +++ L ++ +KE+LRL+P VP+ R D L + IP C++
Sbjct: 364 DREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLIN 423
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
I G++ +P PD + P R+ + P AF FS G R CIG+ +A+ MK L
Sbjct: 424 IIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLA 483
Query: 422 HLIRRYKV 429
+ +++
Sbjct: 484 LTLLHFRI 491
>AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 149 bits (362), Expect = 2e-35
Identities = 98/384 (25%), Positives = 170/384 (44%), Gaps = 5/384 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDF-NQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G ++ MA L FG + Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXX 246
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGAR 293
Query: 247 XXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSE 306
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 294 DEDDIKLSDADLRAEVDTFMFEGHDTTTGGISWFLYCMALYPEHQHRCREEVREILGDQD 353
Query: 307 ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGL 365
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L
Sbjct: 354 F-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYAL 412
Query: 366 NRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIR 425
+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 HRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL 472
Query: 426 RYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 RFEFSLDPSRLPIKMPQLVLRSKN 496
>X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for
cytochrome P-450HP. ).
Length = 511
Score = 149 bits (361), Expect = 2e-35
Identities = 98/384 (25%), Positives = 170/384 (44%), Gaps = 5/384 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDF-NQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G ++ MA L FG + Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXX 246
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGAR 293
Query: 247 XXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSE 306
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 294 DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD 353
Query: 307 ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGL 365
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L
Sbjct: 354 F-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYAL 412
Query: 366 NRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIR 425
+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 HRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL 472
Query: 426 RYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 RFEFSLDPSRLPIKMPQLVLRSKN 496
>J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung
cytochrome P450 (IV subfamily) BI protein, complete cds.
).
Length = 511
Score = 149 bits (361), Expect = 2e-35
Identities = 98/384 (25%), Positives = 170/384 (44%), Gaps = 5/384 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDF-NQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G ++ MA L FG + Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXX 246
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGAR 293
Query: 247 XXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSE 306
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 294 DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD 353
Query: 307 ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGL 365
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L
Sbjct: 354 F-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYAL 412
Query: 366 NRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIR 425
+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 HRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL 472
Query: 426 RYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 RFEFSLDPSRLPIKMPQLVLRSKN 496
>DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 149 bits (361), Expect = 2e-35
Identities = 98/384 (25%), Positives = 170/384 (44%), Gaps = 5/384 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDF-NQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G ++ MA L FG + Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXX 246
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGAR 293
Query: 247 XXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSE 306
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 294 DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD 353
Query: 307 ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGL 365
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L
Sbjct: 354 F-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYAL 412
Query: 366 NRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIR 425
+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 HRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL 472
Query: 426 RYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 RFEFSLDPSRLPIKMPQLVLRSKN 496
>AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 149 bits (361), Expect = 2e-35
Identities = 98/384 (25%), Positives = 170/384 (44%), Gaps = 5/384 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDF-NQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G ++ MA L FG + Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXX 246
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGAR 293
Query: 247 XXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSE 306
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 294 DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD 353
Query: 307 ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGL 365
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L
Sbjct: 354 F-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYAL 412
Query: 366 NRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIR 425
+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 HRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL 472
Query: 426 RYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 RFEFSLDPSRLPIKMPQLVLRSKN 496
>AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 149 bits (361), Expect = 2e-35
Identities = 98/384 (25%), Positives = 170/384 (44%), Gaps = 5/384 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDF-NQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G ++ MA L FG + Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXX 246
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGAR 293
Query: 247 XXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSE 306
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 294 DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD 353
Query: 307 ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGL 365
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L
Sbjct: 354 F-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYAL 412
Query: 366 NRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIR 425
+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 HRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL 472
Query: 426 RYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 RFEFSLDPSRLPIKMPQLVLRSKN 496
>AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 149 bits (361), Expect = 2e-35
Identities = 98/384 (25%), Positives = 170/384 (44%), Gaps = 5/384 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDF-NQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G ++ MA L FG + Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXX 246
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGAR 293
Query: 247 XXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSE 306
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 294 DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCIALYPEHQHRCREEVREILGDQD 353
Query: 307 ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGL 365
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L
Sbjct: 354 F-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYAL 412
Query: 366 NRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIR 425
+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 HRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL 472
Query: 426 RYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 RFEFSLDPSRLPIKMPQLVLRSKN 496
>BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 149 bits (360), Expect = 3e-35
Identities = 98/385 (25%), Positives = 171/385 (44%), Gaps = 6/385 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQ--KYIHSVDKLLSMLIYRFQNVLLHN 185
G ++ MA L FG ++ Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 186 SFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXX 245
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGA 293
Query: 246 XXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDS 305
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD
Sbjct: 294 RDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQ 353
Query: 306 EADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYG 364
+ + Y+ +KE+ RLYP VP RQ + + ++PA S + IY
Sbjct: 354 DF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYA 412
Query: 365 LNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLI 424
L+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 LHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCL 472
Query: 425 RRYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 LRFEFSLDPSRLPIKMPQLVLRSKN 497
>AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P450
4B1 protein.
Length = 512
Score = 149 bits (360), Expect = 3e-35
Identities = 98/385 (25%), Positives = 171/385 (44%), Gaps = 6/385 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQ--KYIHSVDKLLSMLIYRFQNVLLHN 185
G ++ MA L FG ++ Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 186 SFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXX 245
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGA 293
Query: 246 XXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDS 305
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD
Sbjct: 294 RDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQ 353
Query: 306 EADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYG 364
+ + Y+ +KE+ RLYP VP RQ + + ++PA S + IY
Sbjct: 354 DF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYA 412
Query: 365 LNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLI 424
L+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 LHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCL 472
Query: 425 RRYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 LRFEFSLDPSRLPIKMPQLVLRSKN 497
>AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 149 bits (360), Expect = 3e-35
Identities = 98/385 (25%), Positives = 171/385 (44%), Gaps = 6/385 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQ--KYIHSVDKLLSMLIYRFQNVLLHN 185
G ++ MA L FG ++ Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 186 SFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXX 245
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGA 293
Query: 246 XXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDS 305
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD
Sbjct: 294 RDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQ 353
Query: 306 EADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYG 364
+ + Y+ +KE+ RLYP VP RQ + + ++PA S + IY
Sbjct: 354 DF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYA 412
Query: 365 LNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLI 424
L+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 LHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCL 472
Query: 425 RRYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 LRFEFSLDPSRLPIKMPQLVLRSKN 497
>AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 149 bits (360), Expect = 3e-35
Identities = 98/385 (25%), Positives = 171/385 (44%), Gaps = 6/385 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQ--KYIHSVDKLLSMLIYRFQNVLLHN 185
G ++ MA L FG ++ Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 186 SFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXX 245
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGA 293
Query: 246 XXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDS 305
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD
Sbjct: 294 RDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQ 353
Query: 306 EADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYG 364
+ + Y+ +KE+ RLYP VP RQ + + ++PA S + IY
Sbjct: 354 DF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYA 412
Query: 365 LNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLI 424
L+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 LHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCL 472
Query: 425 RRYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 LRFEFSLDPSRLPIKMPQLVLRSKN 497
>AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 148 bits (359), Expect = 4e-35
Identities = 98/384 (25%), Positives = 170/384 (44%), Gaps = 5/384 (1%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F W+G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAWE 174
Query: 129 GP-VEVTTPFRQMAFRLLFLTAFGIPVEDSDF-NQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G ++ MA L FG + Y +V L ++ R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXX 246
FIY ++ ++ + + H ++ +I R+R+A+ + + H
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGAR 293
Query: 247 XXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSE 306
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 294 DEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD 353
Query: 307 ADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGL 365
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L
Sbjct: 354 F-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYAL 412
Query: 366 NRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIR 425
+R+ PD F R+ P AF FS G R CIG+ +A+ MK +
Sbjct: 413 HRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL 472
Query: 426 RYKVTADISKVEFKMDVLMTPVNN 449
R++ + D S++ KM L+ N
Sbjct: 473 RFEFSLDPSRLPIKMPQLVLRSKN 496
>AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein.
Length = 505
Score = 147 bits (357), Expect = 6e-35
Identities = 97/375 (25%), Positives = 175/375 (46%), Gaps = 13/375 (3%)
Query: 68 AYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMA 127
+++ W+G GL+T G WK+HR+++ P FN IL FI + ++ R ++++ +A
Sbjct: 113 SHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIA 172
Query: 128 KGP-VEVTTPFRQMAFRLLFLTAF---GIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLL 183
+ +E+ M + AF G DS + Y+ +V L + R N L
Sbjct: 173 QNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDS-YLKAVFNLSKISNQRMNNFLH 231
Query: 184 HNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXX 243
HN ++K S + + + +H + +I+ ++E+ K+K D R+ +
Sbjct: 232 HNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDT---TQKRRWDFLDIL 288
Query: 244 XXXXXXXXXXXX-XEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
+++ EV T + AG+DT+S ++ ++ L YPE Q + E+ +
Sbjct: 289 LSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL 348
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLY-PIVPIALRQTESDIELKN-YTIPADSNCVL 360
GD + + H + Y +KE LRLY P+V I+ R + I + ++PA +
Sbjct: 349 GDGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNIS-RLLDKPITFPDGRSLPAGITVFI 406
Query: 361 GIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTL 420
I+ L+ +P + D F P R+ P AF FS G R CIG+ +A++ K +
Sbjct: 407 NIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAV 466
Query: 421 VHLIRRYKVTADISK 435
+ R+K+ D S+
Sbjct: 467 ALTLLRFKLAPDHSR 481
>AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein.
Length = 505
Score = 147 bits (357), Expect = 6e-35
Identities = 97/375 (25%), Positives = 175/375 (46%), Gaps = 13/375 (3%)
Query: 68 AYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMA 127
+++ W+G GL+T G WK+HR+++ P FN IL FI + ++ R ++++ +A
Sbjct: 113 SHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIA 172
Query: 128 KGP-VEVTTPFRQMAFRLLFLTAF---GIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLL 183
+ +E+ M + AF G DS + Y+ +V L + R N L
Sbjct: 173 QNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDS-YLKAVFNLSKISNQRMNNFLH 231
Query: 184 HNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXX 243
HN ++K S + + + +H + +I+ ++E+ K+K D R+ +
Sbjct: 232 HNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDT---TQKRRWDFLDIL 288
Query: 244 XXXXXXXXXXXX-XEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
+++ EV T + AG+DT+S ++ ++ L YPE Q + E+ +
Sbjct: 289 LSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL 348
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLY-PIVPIALRQTESDIELKN-YTIPADSNCVL 360
GD + + H + Y +KE LRLY P+V I+ R + I + ++PA +
Sbjct: 349 GDGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNIS-RLLDKPITFPDGRSLPAGITVFI 406
Query: 361 GIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTL 420
I+ L+ +P + D F P R+ P AF FS G R CIG+ +A++ K +
Sbjct: 407 NIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAV 466
Query: 421 VHLIRRYKVTADISK 435
+ R+K+ D S+
Sbjct: 467 ALTLLRFKLAPDHSR 481
>AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 147 bits (357), Expect = 6e-35
Identities = 97/375 (25%), Positives = 175/375 (46%), Gaps = 13/375 (3%)
Query: 68 AYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMA 127
+++ W+G GL+T G WK+HR+++ P FN IL FI + ++ R ++++ +A
Sbjct: 113 SHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIA 172
Query: 128 KGP-VEVTTPFRQMAFRLLFLTAF---GIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLL 183
+ +E+ M + AF G DS + Y+ +V L + R N L
Sbjct: 173 QNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDS-YLKAVFNLSKISNQRMNNFLH 231
Query: 184 HNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXX 243
HN ++K S + + + +H + +I+ ++E+ K+K D R+ +
Sbjct: 232 HNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDT---TQKRRWDFLDIL 288
Query: 244 XXXXXXXXXXXX-XEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
+++ EV T + AG+DT+S ++ ++ L YPE Q + E+ +
Sbjct: 289 LSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL 348
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLY-PIVPIALRQTESDIELKN-YTIPADSNCVL 360
GD + + H + Y +KE LRLY P+V I+ R + I + ++PA +
Sbjct: 349 GDGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNIS-RLLDKPITFPDGRSLPAGITVFI 406
Query: 361 GIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTL 420
I+ L+ +P + D F P R+ P AF FS G R CIG+ +A++ K +
Sbjct: 407 NIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAV 466
Query: 421 VHLIRRYKVTADISK 435
+ R+K+ D S+
Sbjct: 467 ALTLLRFKLAPDHSR 481
>AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 147 bits (357), Expect = 6e-35
Identities = 97/375 (25%), Positives = 175/375 (46%), Gaps = 13/375 (3%)
Query: 68 AYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMA 127
+++ W+G GL+T G WK+HR+++ P FN IL FI + ++ R ++++ +A
Sbjct: 113 SHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIA 172
Query: 128 KGP-VEVTTPFRQMAFRLLFLTAF---GIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLL 183
+ +E+ M + AF G DS + Y+ +V L + R N L
Sbjct: 173 QNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDS-YLKAVFNLSKISNQRMNNFLH 231
Query: 184 HNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXX 243
HN ++K S + + + +H + +I+ ++E+ K+K D R+ +
Sbjct: 232 HNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDT---TQKRRWDFLDIL 288
Query: 244 XXXXXXXXXXXX-XEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
+++ EV T + AG+DT+S ++ ++ L YPE Q + E+ +
Sbjct: 289 LSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL 348
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLY-PIVPIALRQTESDIELKN-YTIPADSNCVL 360
GD + + H + Y +KE LRLY P+V I+ R + I + ++PA +
Sbjct: 349 GDGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNIS-RLLDKPITFPDGRSLPAGITVFI 406
Query: 361 GIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTL 420
I+ L+ +P + D F P R+ P AF FS G R CIG+ +A++ K +
Sbjct: 407 NIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAV 466
Query: 421 VHLIRRYKVTADISK 435
+ R+K+ D S+
Sbjct: 467 ALTLLRFKLAPDHSR 481
>AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein.
Length = 520
Score = 147 bits (357), Expect = 6e-35
Identities = 94/371 (25%), Positives = 170/371 (45%), Gaps = 8/371 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y+ WLGDGL+ S G+ W+ HR+LL PAF+ IL +I +F+ + + ++ +
Sbjct: 125 YKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAME 184
Query: 129 GP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G ++V M L F + +YI ++ +L ++++ R +
Sbjct: 185 GSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKD 244
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXX 243
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 245 FLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLL 304
Query: 244 XXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFG 303
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 305 SEDKNGKELSDE-DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLK 363
Query: 304 DSEA-DVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNY-TIPADSNCVLG 361
D E +++ L ++ LKE+LRL+P +P R D+ L + IP + C +
Sbjct: 364 DREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNIN 423
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLV 421
I+ ++ +P PD + P R+ P AF FS G R CIG+ +A+ MK L
Sbjct: 424 IFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLA 483
Query: 422 HLIRRYKVTAD 432
+ R+++ D
Sbjct: 484 LTLLRFRILPD 494
>BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein.
Length = 455
Score = 142 bits (344), Expect = 2e-33
Identities = 92/343 (26%), Positives = 164/343 (47%), Gaps = 8/343 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKR 404
IYGL+ +P P+ F P R+ PG +AF FS G R
Sbjct: 415 IYGLHHNPKVWPNPEVFDPFRF-APGSA-QHSHAFLPFSGGSR 455
>AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 455
Score = 142 bits (344), Expect = 2e-33
Identities = 92/343 (26%), Positives = 164/343 (47%), Gaps = 8/343 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +YRF + W+G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + AF ++ +Q YI ++ L +++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ S+
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKR 404
IYGL+ +P P+ F P R+ PG +AF FS G R
Sbjct: 415 IYGLHHNPKVWPNPEVFDPFRF-APGSA-QHSHAFLPFSGGSR 455
>AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P450
4B1 variant protein.
Length = 497
Score = 140 bits (340), Expect = 7e-33
Identities = 95/377 (25%), Positives = 167/377 (44%), Gaps = 6/377 (1%)
Query: 77 GDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEVTT 135
G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +G ++
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 136 PFRQMAFRLLFLTAFGIPVEDSDFNQ--KYIHSVDKLLSMLIYRFQNVLLHNSFIYKISG 193
MA L FG ++ Y +V L ++ R + HN FIY ++
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 194 LKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXX 253
++ + + H ++ +I R+R+A+ + + H
Sbjct: 228 HGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKL 286
Query: 254 XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSH 313
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 287 SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDD 345
Query: 314 YPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGLNRHPVWG 372
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L+R+
Sbjct: 346 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 405
Query: 373 PDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD 432
PD F R+ P AF FS G R CIG+ +A+ MK + R++ + D
Sbjct: 406 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 465
Query: 433 ISKVEFKMDVLMTPVNN 449
S++ KM L+ N
Sbjct: 466 PSRLPIKMPQLVLRSKN 482
>AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 140 bits (340), Expect = 7e-33
Identities = 95/377 (25%), Positives = 167/377 (44%), Gaps = 6/377 (1%)
Query: 77 GDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEVTT 135
G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +G ++
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 136 PFRQMAFRLLFLTAFGIPVEDSDFNQ--KYIHSVDKLLSMLIYRFQNVLLHNSFIYKISG 193
MA L FG ++ Y +V L ++ R + HN FIY ++
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 194 LKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXX 253
++ + + H ++ +I R+R+A+ + + H
Sbjct: 228 HGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKL 286
Query: 254 XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSH 313
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 287 SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDD 345
Query: 314 YPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGLNRHPVWG 372
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L+R+
Sbjct: 346 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 405
Query: 373 PDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD 432
PD F R+ P AF FS G R CIG+ +A+ MK + R++ + D
Sbjct: 406 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 465
Query: 433 ISKVEFKMDVLMTPVNN 449
S++ KM L+ N
Sbjct: 466 PSRLPIKMPQLVLRSKN 482
>AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 140 bits (340), Expect = 7e-33
Identities = 95/377 (25%), Positives = 167/377 (44%), Gaps = 6/377 (1%)
Query: 77 GDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEVTT 135
G GL+ G W +HRKLL P F+ +L ++ VF + +R ++ + + +G ++
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 136 PFRQMAFRLLFLTAFGIPVEDSDFNQ--KYIHSVDKLLSMLIYRFQNVLLHNSFIYKISG 193
MA L FG ++ Y +V L ++ R + HN FIY ++
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 194 LKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXX 253
++ + + H ++ +I R+R+A+ + + H
Sbjct: 228 HGRRFLRACQVAHDHTDQVI-RERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKL 286
Query: 254 XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSH 313
++R EVDT + G+DT++ ++ + + YPE Q++ +EV + GD +
Sbjct: 287 SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDD 345
Query: 314 YPGLVYVEAVLKETLRLYPIVPIALRQTESDIE-LKNYTIPADSNCVLGIYGLNRHPVWG 372
+ Y+ +KE+ RLYP VP RQ + + ++PA S + IY L+R+
Sbjct: 346 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 405
Query: 373 PDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD 432
PD F R+ P AF FS G R CIG+ +A+ MK + R++ + D
Sbjct: 406 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 465
Query: 433 ISKVEFKMDVLMTPVNN 449
S++ KM L+ N
Sbjct: 466 PSRLPIKMPQLVLRSKN 482
>BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 139 bits (336), Expect = 2e-32
Identities = 96/412 (23%), Positives = 186/412 (45%), Gaps = 9/412 (2%)
Query: 44 QDYYVITDPVDNLKIANGTFLK-HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQ 102
Q ++ I DP + + T K + +F+ LG GL G W +HR+LL P F+
Sbjct: 88 QAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFN 147
Query: 103 ILNSFIGVFNDESRKLVSEIGN--EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV--EDSD 158
IL ++I V + ++ + VEV M+ ++ AF + +
Sbjct: 148 ILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNS 207
Query: 159 FNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKRE 218
+ Y ++ +L ++ +R ++L H+ I+K+S + +++ ++ ++ II+ +++
Sbjct: 208 THDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKK 267
Query: 219 ASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLT 278
+ + D + I ++ EV T ++AG+DT + ++
Sbjct: 268 SLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDI-DVHSEVSTFLLAGHDTLAASIS 326
Query: 279 LVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIAL 338
++ L PE Q + +EV + GD + + + Y +KET RL P VP
Sbjct: 327 WILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 339 RQTESDIELKN-YTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFA 397
R + + T+PA VL I+GL+ +P + F P R+ + P A+
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYL 445
Query: 398 GFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISK-VEFKMDVLMTPVN 448
FS G R CIG+ +A++ +K T+ ++ ++VT D ++ + F ++ P N
Sbjct: 446 PFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKN 497
>AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein.
Length = 509
Score = 139 bits (336), Expect = 2e-32
Identities = 96/412 (23%), Positives = 186/412 (45%), Gaps = 9/412 (2%)
Query: 44 QDYYVITDPVDNLKIANGTFLK-HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQ 102
Q ++ I DP + + T K + +F+ LG GL G W +HR+LL P F+
Sbjct: 88 QAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFN 147
Query: 103 ILNSFIGVFNDESRKLVSEIGN--EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV--EDSD 158
IL ++I V + ++ + VEV M+ ++ AF + +
Sbjct: 148 ILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNS 207
Query: 159 FNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKRE 218
+ Y ++ +L ++ +R ++L H+ I+K+S + +++ ++ ++ II+ +++
Sbjct: 208 THDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKK 267
Query: 219 ASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLT 278
+ + D + I ++ EV T ++AG+DT + ++
Sbjct: 268 SLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDI-DVHSEVSTFLLAGHDTLAASIS 326
Query: 279 LVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIAL 338
++ L PE Q + +EV + GD + + + Y +KET RL P VP
Sbjct: 327 WILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 339 RQTESDIELKN-YTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFA 397
R + + T+PA VL I+GL+ +P + F P R+ + P A+
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYL 445
Query: 398 GFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISK-VEFKMDVLMTPVN 448
FS G R CIG+ +A++ +K T+ ++ ++VT D ++ + F ++ P N
Sbjct: 446 PFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKN 497
>AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein.
Length = 509
Score = 139 bits (336), Expect = 2e-32
Identities = 96/412 (23%), Positives = 186/412 (45%), Gaps = 9/412 (2%)
Query: 44 QDYYVITDPVDNLKIANGTFLK-HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQ 102
Q ++ I DP + + T K + +F+ LG GL G W +HR+LL P F+
Sbjct: 88 QAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFN 147
Query: 103 ILNSFIGVFNDESRKLVSEIGN--EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV--EDSD 158
IL ++I V + ++ + VEV M+ ++ AF + +
Sbjct: 148 ILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNS 207
Query: 159 FNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKRE 218
+ Y ++ +L ++ +R ++L H+ I+K+S + +++ ++ ++ II+ +++
Sbjct: 208 THDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKK 267
Query: 219 ASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLT 278
+ + D + I ++ EV T ++AG+DT + ++
Sbjct: 268 SLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDI-DVHSEVSTFLLAGHDTLAASIS 326
Query: 279 LVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIAL 338
++ L PE Q + +EV + GD + + + Y +KET RL P VP
Sbjct: 327 WILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 339 RQTESDIELKN-YTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFA 397
R + + T+PA VL I+GL+ +P + F P R+ + P A+
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYL 445
Query: 398 GFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISK-VEFKMDVLMTPVN 448
FS G R CIG+ +A++ +K T+ ++ ++VT D ++ + F ++ P N
Sbjct: 446 PFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKN 497
>AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 139 bits (336), Expect = 2e-32
Identities = 96/412 (23%), Positives = 186/412 (45%), Gaps = 9/412 (2%)
Query: 44 QDYYVITDPVDNLKIANGTFLK-HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQ 102
Q ++ I DP + + T K + +F+ LG GL G W +HR+LL P F+
Sbjct: 88 QAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFN 147
Query: 103 ILNSFIGVFNDESRKLVSEIGN--EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV--EDSD 158
IL ++I V + ++ + VEV M+ ++ AF + +
Sbjct: 148 ILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNS 207
Query: 159 FNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKRE 218
+ Y ++ +L ++ +R ++L H+ I+K+S + +++ ++ ++ II+ +++
Sbjct: 208 THDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKK 267
Query: 219 ASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLT 278
+ + D + I ++ EV T ++AG+DT + ++
Sbjct: 268 SLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDI-DVHSEVSTFLLAGHDTLAASIS 326
Query: 279 LVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIAL 338
++ L PE Q + +EV + GD + + + Y +KET RL P VP
Sbjct: 327 WILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 339 RQTESDIELKN-YTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFA 397
R + + T+PA VL I+GL+ +P + F P R+ + P A+
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYL 445
Query: 398 GFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISK-VEFKMDVLMTPVN 448
FS G R CIG+ +A++ +K T+ ++ ++VT D ++ + F ++ P N
Sbjct: 446 PFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKN 497
>AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens
cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 509
Score = 139 bits (336), Expect = 2e-32
Identities = 96/412 (23%), Positives = 186/412 (45%), Gaps = 9/412 (2%)
Query: 44 QDYYVITDPVDNLKIANGTFLK-HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQ 102
Q ++ I DP + + T K + +F+ LG GL G W +HR+LL P F+
Sbjct: 88 QAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFN 147
Query: 103 ILNSFIGVFNDESRKLVSEIGN--EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV--EDSD 158
IL ++I V + ++ + VEV M+ ++ AF + +
Sbjct: 148 ILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNS 207
Query: 159 FNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKRE 218
+ Y ++ +L ++ +R ++L H+ I+K+S + +++ ++ ++ II+ +++
Sbjct: 208 THDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKK 267
Query: 219 ASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLT 278
+ + D + I ++ EV T ++AG+DT + ++
Sbjct: 268 SLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDI-DVHSEVSTFLLAGHDTLAASIS 326
Query: 279 LVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIAL 338
++ L PE Q + +EV + GD + + + Y +KET RL P VP
Sbjct: 327 WILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSIS 385
Query: 339 RQTESDIELKN-YTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFA 397
R + + T+PA VL I+GL+ +P + F P R+ + P A+
Sbjct: 386 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYL 445
Query: 398 GFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISK-VEFKMDVLMTPVN 448
FS G R CIG+ +A++ +K T+ ++ ++VT D ++ + F ++ P N
Sbjct: 446 PFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKN 497
>AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens
cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 444
Score = 139 bits (336), Expect = 2e-32
Identities = 96/412 (23%), Positives = 186/412 (45%), Gaps = 9/412 (2%)
Query: 44 QDYYVITDPVDNLKIANGTFLK-HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQ 102
Q ++ I DP + + T K + +F+ LG GL G W +HR+LL P F+
Sbjct: 23 QAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFN 82
Query: 103 ILNSFIGVFNDESRKLVSEIGN--EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV--EDSD 158
IL ++I V + ++ + VEV M+ ++ AF + +
Sbjct: 83 ILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNS 142
Query: 159 FNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKRE 218
+ Y ++ +L ++ +R ++L H+ I+K+S + +++ ++ ++ II+ +++
Sbjct: 143 THDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKK 202
Query: 219 ASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLT 278
+ + D + I ++ EV T ++AG+DT + ++
Sbjct: 203 SLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDI-DVHSEVSTFLLAGHDTLAASIS 261
Query: 279 LVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIAL 338
++ L PE Q + +EV + GD + + + Y +KET RL P VP
Sbjct: 262 WILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSIS 320
Query: 339 RQTESDIELKN-YTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFA 397
R + + T+PA VL I+GL+ +P + F P R+ + P A+
Sbjct: 321 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYL 380
Query: 398 GFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISK-VEFKMDVLMTPVN 448
FS G R CIG+ +A++ +K T+ ++ ++VT D ++ + F ++ P N
Sbjct: 381 PFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKN 432
>AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens
cDNA FLJ16384 fis, clone TLIVE2007607, weakly similar
to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 508
Score = 138 bits (335), Expect = 3e-32
Identities = 96/412 (23%), Positives = 186/412 (45%), Gaps = 9/412 (2%)
Query: 44 QDYYVITDPVDNLKIANGTFLK-HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQ 102
Q ++ I DP + + T K + +F+ LG GL G W +HR+LL P F+
Sbjct: 87 QAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFN 146
Query: 103 ILNSFIGVFNDESRKLVSEIGN--EMAKGPVEVTTPFRQMAFRLLFLTAFGIPV--EDSD 158
IL ++I V + ++ + VEV M+ ++ AF + +
Sbjct: 147 ILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIVMKCAFSKETNCQTNS 206
Query: 159 FNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKRE 218
+ Y ++ +L ++ +R ++L H+ I+K+S + +++ ++ ++ II+ +++
Sbjct: 207 THDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKK 266
Query: 219 ASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLT 278
+ + D + I ++ EV T ++AG+DT + ++
Sbjct: 267 SLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDI-DVHSEVSTFLLAGHDTLAASIS 325
Query: 279 LVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIAL 338
++ L PE Q + +EV + GD + + + Y +KET RL P VP
Sbjct: 326 WILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSIS 384
Query: 339 RQTESDIELKN-YTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFA 397
R + + T+PA VL I+GL+ +P + F P R+ + P A+
Sbjct: 385 RDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYL 444
Query: 398 GFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISK-VEFKMDVLMTPVN 448
FS G R CIG+ +A++ +K T+ ++ ++VT D ++ + F ++ P N
Sbjct: 445 PFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKN 496
>AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 455
Score = 134 bits (325), Expect = 5e-31
Identities = 89/343 (25%), Positives = 162/343 (47%), Gaps = 8/343 (2%)
Query: 66 HFAYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNE 125
H +Y+F + +G GL+ +G+TW +HR++L PAF+ IL ++G+ D R ++ +
Sbjct: 117 HGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEEL 176
Query: 126 MAK-GPVEVTTPFRQMAFRLLFLTAFGI--PVEDSDFNQKYIHSVDKLLSMLIYRFQNVL 182
+ + P+EV M + +AF ++ +Q YI ++ L S++ +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAF 236
Query: 183 LHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXX 242
N IY ++ + + + H ++ +I + R+A K E H
Sbjct: 237 HENDTIYSLTSAGRWTHRACQLAHQHTDQVI-QLRKAQLQKEGELEKIKRKRHLDFLDIL 295
Query: 243 XXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF 302
++R EVDT + G+DT++ ++ ++ AL ++P+ Q + +E+ +
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLL 355
Query: 303 GDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLG 361
GD A + +H + Y +KE LRLYP VP R+ + + + ++P +L
Sbjct: 356 GDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLS 414
Query: 362 IYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKR 404
IYGL+ +P P+ F P R+ PG +AF FS G R
Sbjct: 415 IYGLHHNPKVWPNLEVFDPSRF-APGSA-QHSHAFLPFSGGSR 455
>J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3
protein.
Length = 502
Score = 118 bits (283), Expect = 6e-26
Identities = 93/379 (24%), Positives = 168/379 (44%), Gaps = 14/379 (3%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + LV + E KG PV + F + +
Sbjct: 124 EEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSM--LIYRFQNVLLHNSFIYKISGLKKKEEQI 201
+ T+FG+ ++ + Q ++ S K L L F +++L F+ +
Sbjct: 184 ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILF-PFLTPVFEALNVSLFP 242
Query: 202 VETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDE 261
+T++ +S + + K+ +K +H D E+ +
Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQ---KHRLDFLQLMID-SQNSKETESHKALSDLELAAQ 298
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVE 321
I AGY+T+S VL+ + L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 299 SIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLD 357
Query: 322 AVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ ETLRL+P+ R + D+E+ IP S V+ Y L+ P + + FRPE
Sbjct: 358 MVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPE 417
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV-TADISKVEFKM 440
R+ + DP + F G R CIG +ALM+MK L+ +++ + +++ K+
Sbjct: 418 RFSKKKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476
Query: 441 DV--LMTPVNNCNVKFELR 457
D L+ P +K + R
Sbjct: 477 DTQGLLQPEKPIVLKVDSR 495
>BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 protein.
Length = 502
Score = 118 bits (283), Expect = 6e-26
Identities = 93/379 (24%), Positives = 168/379 (44%), Gaps = 14/379 (3%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + LV + E KG PV + F + +
Sbjct: 124 EEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSM--LIYRFQNVLLHNSFIYKISGLKKKEEQI 201
+ T+FG+ ++ + Q ++ S K L L F +++L F+ +
Sbjct: 184 ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILF-PFLTPVFEALNVSLFP 242
Query: 202 VETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDE 261
+T++ +S + + K+ +K +H D E+ +
Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQ---KHRLDFLQLMID-SQNSKETESHKALSDLELAAQ 298
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVE 321
I AGY+T+S VL+ + L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 299 SIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLD 357
Query: 322 AVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ ETLRL+P+ R + D+E+ IP S V+ Y L+ P + + FRPE
Sbjct: 358 MVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPE 417
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV-TADISKVEFKM 440
R+ + DP + F G R CIG +ALM+MK L+ +++ + +++ K+
Sbjct: 418 RFSKKKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476
Query: 441 DV--LMTPVNNCNVKFELR 457
D L+ P +K + R
Sbjct: 477 DTQGLLQPEKPIVLKVDSR 495
>AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein.
Length = 502
Score = 118 bits (283), Expect = 6e-26
Identities = 93/379 (24%), Positives = 168/379 (44%), Gaps = 14/379 (3%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + LV + E KG PV + F + +
Sbjct: 124 EEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSM--LIYRFQNVLLHNSFIYKISGLKKKEEQI 201
+ T+FG+ ++ + Q ++ S K L L F +++L F+ +
Sbjct: 184 ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILF-PFLTPVFEALNVSLFP 242
Query: 202 VETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDE 261
+T++ +S + + K+ +K +H D E+ +
Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQ---KHRLDFLQLMID-SQNSKETESHKALSDLELAAQ 298
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVE 321
I AGY+T+S VL+ + L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 299 SIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLD 357
Query: 322 AVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ ETLRL+P+ R + D+E+ IP S V+ Y L+ P + + FRPE
Sbjct: 358 MVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPE 417
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV-TADISKVEFKM 440
R+ + DP + F G R CIG +ALM+MK L+ +++ + +++ K+
Sbjct: 418 RFSKKKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476
Query: 441 DV--LMTPVNNCNVKFELR 457
D L+ P +K + R
Sbjct: 477 DTQGLLQPEKPIVLKVDSR 495
>AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 variant protein.
Length = 502
Score = 116 bits (279), Expect = 2e-25
Identities = 93/379 (24%), Positives = 167/379 (44%), Gaps = 14/379 (3%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + LV + E KG PV + F + +
Sbjct: 124 EEWKRIRPLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSM--LIYRFQNVLLHNSFIYKISGLKKKEEQI 201
+ T+FG+ ++ + Q ++ S K L L F +++L F+ +
Sbjct: 184 ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILF-PFLTPVFEALNVSLFP 242
Query: 202 VETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDE 261
+T++ +S + + K+ +K +H D E+ +
Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQ---KHRLDFLQLMID-SQNSKETESHKALSDLELAAQ 298
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVE 321
I AGY+T+S VL+ + L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 299 SIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLD 357
Query: 322 AVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ ETLRL+P+ R D+E+ IP S V+ Y L+ P + + FRPE
Sbjct: 358 MVVNETLRLFPVAIRLERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPE 417
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV-TADISKVEFKM 440
R+ + DP + F G R CIG +ALM+MK L+ +++ + +++ K+
Sbjct: 418 RFSKKKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476
Query: 441 DV--LMTPVNNCNVKFELR 457
D L+ P +K + R
Sbjct: 477 DTQGLLQPEKPIVLKVDSR 495
>M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver
glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
complete cds. ).
Length = 504
Score = 115 bits (277), Expect = 3e-25
Identities = 84/344 (24%), Positives = 150/344 (43%), Gaps = 5/344 (1%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVET 204
+ ++FG+ V+ + Q + V+ +L + F + + ++ + I
Sbjct: 184 ITSSSFGVNVDSLNNPQDPL--VENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVF 241
Query: 205 VHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVD 263
++N + K KR T +H D E+ +
Sbjct: 242 PREVTNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSI 301
Query: 264 TIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAV 323
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++ V
Sbjct: 302 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMV 360
Query: 324 LKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERW 383
+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER+
Sbjct: 361 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF 420
Query: 384 LEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 421 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 464
>D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein.
Length = 504
Score = 115 bits (277), Expect = 3e-25
Identities = 84/344 (24%), Positives = 150/344 (43%), Gaps = 5/344 (1%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVET 204
+ ++FG+ V+ + Q + V+ +L + F + + ++ + I
Sbjct: 184 ITSSSFGVNVDSLNNPQDPL--VENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVF 241
Query: 205 VHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVD 263
++N + K KR T +H D E+ +
Sbjct: 242 PREVTNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSHKNSKETESHKALSDLELVAQSI 301
Query: 264 TIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAV 323
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++ V
Sbjct: 302 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMV 360
Query: 324 LKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERW 383
+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER+
Sbjct: 361 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF 420
Query: 384 LEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 421 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 464
>M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA
encoding nifedipine oxidase, complete cds. ).
Length = 503
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrome
P-450 nifedipine oxidase mRNA, complet cds. ).
Length = 503
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family 3
subfamily A polypeptide 4 protein.
Length = 503
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfamily
IIIA, polypeptide 4 protein.
Length = 503
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein.
Length = 430
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 51 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 110
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 111 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 167
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 168 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 227
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 228 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 285
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 286 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 345
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 346 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 390
>AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein.
Length = 503
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450
polypeptide 4 protein.
Length = 503
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4
protein.
Length = 503
Score = 113 bits (273), Expect = 9e-25
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (cyp3 locus). ).
Length = 503
Score = 113 bits (272), Expect = 1e-24
Identities = 84/345 (24%), Positives = 150/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipine
oxidase protein.
Length = 502
Score = 113 bits (272), Expect = 1e-24
Identities = 87/345 (25%), Positives = 149/345 (43%), Gaps = 9/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL L F + I L+ I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLRFDF--LDPFFLSIIFPFLIPILEVLN--ICV 239
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 240 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 299
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 300 -IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 357
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 358 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPER 417
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 418 FSKKNKDNIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 462
>AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4
protein.
Length = 503
Score = 110 bits (264), Expect = 1e-23
Identities = 83/345 (24%), Positives = 149/345 (43%), Gaps = 8/345 (2%)
Query: 86 ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVTTPFRQMAFRL 144
E WKR R LL+P F L + + LV + E G PV + F + +
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
Query: 145 LFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQIVE 203
+ T+FG+ ++ + Q ++ + KLL + F + + ++ + I
Sbjct: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICV 240
Query: 204 TVHAMSNMIIKR-KREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEV 262
++N + K KR T +H D + +
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300
Query: 263 DTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEA 322
I AG +T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++
Sbjct: 301 -IFIFAGCETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDM 358
Query: 323 VLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
V+ ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein.
Length = 372
Score = 108 bits (260), Expect = 3e-23
Identities = 66/205 (32%), Positives = 105/205 (51%), Gaps = 4/205 (1%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI V +++AG DT+S+ L+ + L +PE+Q VY+E+ G+ + P
Sbjct: 169 EIYANVTEMLLAGVDTTSFTLSWTVYILARHPEVQQTVYREIVKNLGERHVPT-AADVPK 227
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ V A+LKETLRL+P++P R T+ D+ + Y IP + L Y + P A
Sbjct: 228 VPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAK 287
Query: 377 TFRPERWLEPGGVPDDPN-AFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY--KVTADI 433
FRPERWL G + N F G R+CIG+ A + + ++ L++ + K ++
Sbjct: 288 EFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQT 347
Query: 434 SKVEFKMDVLMTPVNNCNVKFELRK 458
+ V K L+TP +V+F RK
Sbjct: 348 NAVHAKTHGLLTPGGPIHVRFVNRK 372
>AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein.
Length = 372
Score = 108 bits (260), Expect = 3e-23
Identities = 66/205 (32%), Positives = 105/205 (51%), Gaps = 4/205 (1%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI V +++AG DT+S+ L+ + L +PE+Q VY+E+ G+ + P
Sbjct: 169 EIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPT-AADVPK 227
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ V A+LKETLRL+P++P R T+ D+ + Y IP + L Y + P A
Sbjct: 228 VPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAK 287
Query: 377 TFRPERWLEPGGVPDDPN-AFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY--KVTADI 433
FRPERWL G + N F G R+CIG+ A + + ++ L++ + K ++
Sbjct: 288 EFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQT 347
Query: 434 SKVEFKMDVLMTPVNNCNVKFELRK 458
+ V K L+TP +V+F RK
Sbjct: 348 NAVHAKTHGLLTPGGPIHVRFVNRK 372
>AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43.3
protein.
Length = 503
Score = 107 bits (258), Expect = 6e-23
Identities = 91/390 (23%), Positives = 167/390 (42%), Gaps = 13/390 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEV 133
+L L + E WKR R LL+PAF + + + LV + E + +
Sbjct: 113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F ++ T FG+ ++ + Q ++ ++ KLL L + +LL + F +
Sbjct: 173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK-LDFLDPFLLLISLFPFLTP 231
Query: 193 GLKKKEEQIV--ETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
+ + + H + N I + K K+K +H D +
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKETKSHK 288
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVD 310
+ + II A YDT+S L +M L ++P++Q K+ +E+ ++ + +A V
Sbjct: 289 ALSDLELVAQSI-IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLAN-KAPVT 346
Query: 311 KSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPV 370
+ Y++ V+ ETLRL+P+V R + DIE+ IP ++ IY L+ P
Sbjct: 347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406
Query: 371 WGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV- 429
+ + F PER+ + D + F G R CIG +AL ++K ++ ++ +
Sbjct: 407 YWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466
Query: 430 TADISKVEFKMDVL--MTPVNNCNVKFELR 457
+++ K+D L + P +K LR
Sbjct: 467 PCKETQIPLKLDNLPILQPEKPIVLKVHLR 496
>AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43.1
protein.
Length = 503
Score = 107 bits (257), Expect = 8e-23
Identities = 91/390 (23%), Positives = 167/390 (42%), Gaps = 13/390 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEV 133
+L L + E WKR R LL+PAF + + + LV + E + +
Sbjct: 113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F ++ T FG+ ++ + Q ++ ++ KLL L + +LL + F +
Sbjct: 173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK-LDFLDPFLLLISLFPFLTP 231
Query: 193 GLKKKEEQIV--ETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
+ + + H + N I + K K+K +H D +
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKETKSHK 288
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVD 310
+ + II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V
Sbjct: 289 ALSDLELVAQSI-IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVT 346
Query: 311 KSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPV 370
+ Y++ V+ ETLRL+P+V R + DIE+ IP ++ IY L+ P
Sbjct: 347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406
Query: 371 WGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV- 429
+ + F PER+ + D + F G R CIG +AL ++K ++ ++ +
Sbjct: 407 YWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466
Query: 430 TADISKVEFKMDVL--MTPVNNCNVKFELR 457
+++ K+D L + P +K LR
Sbjct: 467 PCKETQIPLKLDNLPILQPEKPIVLKVHLR 496
>AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 107 bits (257), Expect = 8e-23
Identities = 91/390 (23%), Positives = 167/390 (42%), Gaps = 13/390 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEV 133
+L L + E WKR R LL+PAF + + + LV + E + +
Sbjct: 113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F ++ T FG+ ++ + Q ++ ++ KLL L + +LL + F +
Sbjct: 173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK-LDFLDPFLLLISLFPFLTP 231
Query: 193 GLKKKEEQIV--ETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
+ + + H + N I + K K+K +H D +
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKETKSHK 288
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVD 310
+ + II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V
Sbjct: 289 ALSDLELVAQSI-IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVT 346
Query: 311 KSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPV 370
+ Y++ V+ ETLRL+P+V R + DIE+ IP ++ IY L+ P
Sbjct: 347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406
Query: 371 WGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV- 429
+ + F PER+ + D + F G R CIG +AL ++K ++ ++ +
Sbjct: 407 YWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466
Query: 430 TADISKVEFKMDVL--MTPVNNCNVKFELR 457
+++ K+D L + P +K LR
Sbjct: 467 PCKETQIPLKLDNLPILQPEKPIVLKVHLR 496
>AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43
protein.
Length = 503
Score = 107 bits (257), Expect = 8e-23
Identities = 91/390 (23%), Positives = 167/390 (42%), Gaps = 13/390 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEV 133
+L L + E WKR R LL+PAF + + + LV + E + +
Sbjct: 113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F ++ T FG+ ++ + Q ++ ++ KLL L + +LL + F +
Sbjct: 173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK-LDFLDPFLLLISLFPFLTP 231
Query: 193 GLKKKEEQIV--ETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
+ + + H + N I + K K+K +H D +
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKETKSHK 288
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVD 310
+ + II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V
Sbjct: 289 ALSDLELVAQSI-IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVT 346
Query: 311 KSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPV 370
+ Y++ V+ ETLRL+P+V R + DIE+ IP ++ IY L+ P
Sbjct: 347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406
Query: 371 WGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV- 429
+ + F PER+ + D + F G R CIG +AL ++K ++ ++ +
Sbjct: 407 YWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466
Query: 430 TADISKVEFKMDVL--MTPVNNCNVKFELR 457
+++ K+D L + P +K LR
Sbjct: 467 PCKETQIPLKLDNLPILQPEKPIVLKVHLR 496
>AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 107 bits (257), Expect = 8e-23
Identities = 91/390 (23%), Positives = 167/390 (42%), Gaps = 13/390 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEV 133
+L L + E WKR R LL+PAF + + + LV + E + +
Sbjct: 113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F ++ T FG+ ++ + Q ++ ++ KLL L + +LL + F +
Sbjct: 173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK-LDFLDPFLLLISLFPFLTP 231
Query: 193 GLKKKEEQIV--ETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
+ + + H + N I + K K+K +H D +
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKETKSHK 288
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVD 310
+ + II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V
Sbjct: 289 ALSDLELVAQSI-IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVT 346
Query: 311 KSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPV 370
+ Y++ V+ ETLRL+P+V R + DIE+ IP ++ IY L+ P
Sbjct: 347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406
Query: 371 WGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV- 429
+ + F PER+ + D + F G R CIG +AL ++K ++ ++ +
Sbjct: 407 YWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466
Query: 430 TADISKVEFKMDVL--MTPVNNCNVKFELR 457
+++ K+D L + P +K LR
Sbjct: 467 PCKETQIPLKLDNLPILQPEKPIVLKVHLR 496
>AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein.
Length = 503
Score = 107 bits (257), Expect = 8e-23
Identities = 91/390 (23%), Positives = 167/390 (42%), Gaps = 13/390 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEV 133
+L L + E WKR R LL+PAF + + + LV + E + +
Sbjct: 113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F ++ T FG+ ++ + Q ++ ++ KLL L + +LL + F +
Sbjct: 173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK-LDFLDPFLLLISLFPFLTP 231
Query: 193 GLKKKEEQIV--ETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
+ + + H + N I + K K+K +H D +
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKETKSHK 288
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVD 310
+ + II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V
Sbjct: 289 ALSDLELVAQSI-IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVT 346
Query: 311 KSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPV 370
+ Y++ V+ ETLRL+P+V R + DIE+ IP ++ IY L+ P
Sbjct: 347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406
Query: 371 WGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV- 429
+ + F PER+ + D + F G R CIG +AL ++K ++ ++ +
Sbjct: 407 YWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466
Query: 430 TADISKVEFKMDVL--MTPVNNCNVKFELR 457
+++ K+D L + P +K LR
Sbjct: 467 PCKETQIPLKLDNLPILQPEKPIVLKVHLR 496
>D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa
protein.
Length = 503
Score = 106 bits (255), Expect = 1e-22
Identities = 86/358 (24%), Positives = 157/358 (43%), Gaps = 12/358 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEV 133
++ + + + E WKR R LL+P F L + + LV + E G PV +
Sbjct: 113 FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F + ++ T+FG+ ++ + Q ++ + KLL RF + I
Sbjct: 173 KHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL-----RFNPLDPFVLSIKVFP 227
Query: 193 GLKKKEEQIVETV--HAMSNMIIKRKREASKNK-SPTDEHCYDTTHRYKSIXXXXXXXXX 249
L E + TV + + + K ++ + + T +H D
Sbjct: 228 FLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMID-SQNSKDSET 286
Query: 250 XXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV 309
E+ + I AGY+T+S VL+ ++ L ++P++Q KV +E+ ++ ++A
Sbjct: 287 HKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPP 345
Query: 310 DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHP 369
L Y++ V+ ETLRL+P+ R + D+E+ IP ++ Y L+ P
Sbjct: 346 TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDP 405
Query: 370 VWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + F PER+ + DP + F G R CIG +AL++MK LV +++ +
Sbjct: 406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 7 protein.
Length = 503
Score = 106 bits (255), Expect = 1e-22
Identities = 86/358 (24%), Positives = 157/358 (43%), Gaps = 12/358 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEV 133
++ + + + E WKR R LL+P F L + + LV + E G PV +
Sbjct: 113 FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F + ++ T+FG+ ++ + Q ++ + KLL RF + I
Sbjct: 173 KHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL-----RFNPLDPFVLSIKVFP 227
Query: 193 GLKKKEEQIVETV--HAMSNMIIKRKREASKNK-SPTDEHCYDTTHRYKSIXXXXXXXXX 249
L E + TV + + + K ++ + + T +H D
Sbjct: 228 FLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMID-SQNSKDSET 286
Query: 250 XXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV 309
E+ + I AGY+T+S VL+ ++ L ++P++Q KV +E+ ++ ++A
Sbjct: 287 HKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPP 345
Query: 310 DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHP 369
L Y++ V+ ETLRL+P+ R + D+E+ IP ++ Y L+ P
Sbjct: 346 TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDP 405
Query: 370 VWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + F PER+ + DP + F G R CIG +AL++MK LV +++ +
Sbjct: 406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family
27, subfamily B, polypeptide 1 protein.
Length = 508
Score = 106 bits (255), Expect = 1e-22
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 4/200 (2%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD-SEADVDKSHYPG 316
I V +++AG DT S L+ + L +PE+Q ++ E+++ S A +
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L ++AV+KE LRLYP+VP R + DI + +Y IP ++ L Y +R P P+ +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD--IS 434
+FRP RWL G P P A F GKR+C+G+ A + ++ L ++ ++V + +
Sbjct: 427 SFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485
Query: 435 KVEFKMDVLMTPVNNCNVKF 454
V K ++ P + N++F
Sbjct: 486 PVRPKTRTVLVPERSINLQF 505
Score = 32.3 bits (70), Expect = 3.7
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 1/52 (1%)
Query: 79 GLITSSGETWKRHRKLLNP-AFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
GL+T+ GE W+R R LL P Q + G N+ LV + + +G
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRG 176
>AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant
3A7 protein.
Length = 535
Score = 106 bits (255), Expect = 1e-22
Identities = 86/358 (24%), Positives = 157/358 (43%), Gaps = 12/358 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEV 133
++ + + + E WKR R LL+P F L + + LV + E G PV +
Sbjct: 113 FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F + ++ T+FG+ ++ + Q ++ + KLL RF + I
Sbjct: 173 KHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL-----RFNPLDPFVLSIKVFP 227
Query: 193 GLKKKEEQIVETV--HAMSNMIIKRKREASKNK-SPTDEHCYDTTHRYKSIXXXXXXXXX 249
L E + TV + + + K ++ + + T +H D
Sbjct: 228 FLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMID-SQNSKDSET 286
Query: 250 XXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV 309
E+ + I AGY+T+S VL+ ++ L ++P++Q KV +E+ ++ ++A
Sbjct: 287 HKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPP 345
Query: 310 DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHP 369
L Y++ V+ ETLRL+P+ R + D+E+ IP ++ Y L+ P
Sbjct: 346 TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDP 405
Query: 370 VWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + F PER+ + DP + F G R CIG +AL++MK LV +++ +
Sbjct: 406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450
polypeptide 7 protein.
Length = 503
Score = 106 bits (255), Expect = 1e-22
Identities = 86/358 (24%), Positives = 157/358 (43%), Gaps = 12/358 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG-PVEV 133
++ + + + E WKR R LL+P F L + + LV + E G PV +
Sbjct: 113 FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F + ++ T+FG+ ++ + Q ++ + KLL RF + I
Sbjct: 173 KHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLL-----RFNPLDPFVLSIKVFP 227
Query: 193 GLKKKEEQIVETV--HAMSNMIIKRKREASKNK-SPTDEHCYDTTHRYKSIXXXXXXXXX 249
L E + TV + + + K ++ + + T +H D
Sbjct: 228 FLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMID-SQNSKDSET 286
Query: 250 XXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV 309
E+ + I AGY+T+S VL+ ++ L ++P++Q KV +E+ ++ ++A
Sbjct: 287 HKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPP 345
Query: 310 DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHP 369
L Y++ V+ ETLRL+P+ R + D+E+ IP ++ Y L+ P
Sbjct: 346 TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDP 405
Query: 370 VWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ + F PER+ + DP + F G R CIG +AL++MK LV +++ +
Sbjct: 406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 106 bits (255), Expect = 1e-22
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 4/200 (2%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD-SEADVDKSHYPG 316
I V +++AG DT S L+ + L +PE+Q ++ E+++ S A +
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L ++AV+KE LRLYP+VP R + DI + +Y IP ++ L Y +R P P+ +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD--IS 434
+FRP RWL G P P A F GKR+C+G+ A + ++ L ++ ++V + +
Sbjct: 427 SFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485
Query: 435 KVEFKMDVLMTPVNNCNVKF 454
V K ++ P + N++F
Sbjct: 486 PVRPKTRTVLVPERSINLQF 505
Score = 32.3 bits (70), Expect = 3.7
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 1/52 (1%)
Query: 79 GLITSSGETWKRHRKLLNP-AFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
GL+T+ GE W+R R LL P Q + G N+ LV + + +G
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRG 176
>AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 106 bits (255), Expect = 1e-22
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 4/200 (2%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD-SEADVDKSHYPG 316
I V +++AG DT S L+ + L +PE+Q ++ E+++ S A +
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L ++AV+KE LRLYP+VP R + DI + +Y IP ++ L Y +R P P+ +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD--IS 434
+FRP RWL G P P A F GKR+C+G+ A + ++ L ++ ++V + +
Sbjct: 427 SFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485
Query: 435 KVEFKMDVLMTPVNNCNVKF 454
V K ++ P + N++F
Sbjct: 486 PVRPKTRTVLVPERSINLQF 505
Score = 32.3 bits (70), Expect = 3.7
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 1/52 (1%)
Query: 79 GLITSSGETWKRHRKLLNP-AFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
GL+T+ GE W+R R LL P Q + G N+ LV + + +G
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRG 176
>AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin D-1
alpha hydroxylase protein.
Length = 508
Score = 106 bits (255), Expect = 1e-22
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 4/200 (2%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD-SEADVDKSHYPG 316
I V +++AG DT S L+ + L +PE+Q ++ E+++ S A +
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L ++AV+KE LRLYP+VP R + DI + +Y IP ++ L Y +R P P+ +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD--IS 434
+FRP RWL G P P A F GKR+C+G+ A + ++ L ++ ++V + +
Sbjct: 427 SFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485
Query: 435 KVEFKMDVLMTPVNNCNVKF 454
V K ++ P + N++F
Sbjct: 486 PVRPKTRTVLVPERSINLQF 505
Score = 32.3 bits (70), Expect = 3.7
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 1/52 (1%)
Query: 79 GLITSSGETWKRHRKLLNP-AFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
GL+T+ GE W+R R LL P Q + G N+ LV + + +G
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRG 176
>AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 106 bits (255), Expect = 1e-22
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 4/200 (2%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD-SEADVDKSHYPG 316
I V +++AG DT S L+ + L +PE+Q ++ E+++ S A +
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L ++AV+KE LRLYP+VP R + DI + +Y IP ++ L Y +R P P+ +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD--IS 434
+FRP RWL G P P A F GKR+C+G+ A + ++ L ++ ++V + +
Sbjct: 427 SFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485
Query: 435 KVEFKMDVLMTPVNNCNVKF 454
V K ++ P + N++F
Sbjct: 486 PVRPKTRTVLVPERSINLQF 505
Score = 32.3 bits (70), Expect = 3.7
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 1/52 (1%)
Query: 79 GLITSSGETWKRHRKLLNP-AFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
GL+T+ GE W+R R LL P Q + G N+ LV + + +G
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRG 176
>AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 106 bits (255), Expect = 1e-22
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 4/200 (2%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD-SEADVDKSHYPG 316
I V +++AG DT S L+ + L +PE+Q ++ E+++ S A +
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L ++AV+KE LRLYP+VP R + DI + +Y IP ++ L Y +R P P+ +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD--IS 434
+FRP RWL G P P A F GKR+C+G+ A + ++ L ++ ++V + +
Sbjct: 427 SFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485
Query: 435 KVEFKMDVLMTPVNNCNVKF 454
V K ++ P + N++F
Sbjct: 486 PVRPKTRTVLVPERSINLQF 505
Score = 32.3 bits (70), Expect = 3.7
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 1/52 (1%)
Query: 79 GLITSSGETWKRHRKLLNP-AFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
GL+T+ GE W+R R LL P Q + G N+ LV + + +G
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRG 176
>AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 106 bits (255), Expect = 1e-22
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 4/200 (2%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD-SEADVDKSHYPG 316
I V +++AG DT S L+ + L +PE+Q ++ E+++ S A +
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L ++AV+KE LRLYP+VP R + DI + +Y IP ++ L Y +R P P+ +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD--IS 434
+FRP RWL G P P A F GKR+C+G+ A + ++ L ++ ++V + +
Sbjct: 427 SFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485
Query: 435 KVEFKMDVLMTPVNNCNVKF 454
V K ++ P + N++F
Sbjct: 486 PVRPKTRTVLVPERSINLQF 505
Score = 32.3 bits (70), Expect = 3.7
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 1/52 (1%)
Query: 79 GLITSSGETWKRHRKLLNP-AFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
GL+T+ GE W+R R LL P Q + G N+ LV + + +G
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRG 176
>AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 106 bits (255), Expect = 1e-22
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 4/200 (2%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD-SEADVDKSHYPG 316
I V +++AG DT S L+ + L +PE+Q ++ E+++ S A +
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L ++AV+KE LRLYP+VP R + DI + +Y IP ++ L Y +R P P+ +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD--IS 434
+FRP RWL G P P A F GKR+C+G+ A + ++ L ++ ++V + +
Sbjct: 427 SFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485
Query: 435 KVEFKMDVLMTPVNNCNVKF 454
V K ++ P + N++F
Sbjct: 486 PVRPKTRTVLVPERSINLQF 505
Score = 32.3 bits (70), Expect = 3.7
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 1/52 (1%)
Query: 79 GLITSSGETWKRHRKLLNP-AFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
GL+T+ GE W+R R LL P Q + G N+ LV + + +G
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRG 176
>AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 106 bits (255), Expect = 1e-22
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 4/200 (2%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD-SEADVDKSHYPG 316
I V +++AG DT S L+ + L +PE+Q ++ E+++ S A +
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L ++AV+KE LRLYP+VP R + DI + +Y IP ++ L Y +R P P+ +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD--IS 434
+FRP RWL G P P A F GKR+C+G+ A + ++ L ++ ++V + +
Sbjct: 427 SFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAA 485
Query: 435 KVEFKMDVLMTPVNNCNVKF 454
V K ++ P + N++F
Sbjct: 486 PVRPKTRTVLVPERSINLQF 505
Score = 32.3 bits (70), Expect = 3.7
Identities = 17/52 (32%), Positives = 25/52 (48%), Gaps = 1/52 (1%)
Query: 79 GLITSSGETWKRHRKLLNP-AFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
GL+T+ GE W+R R LL P Q + G N+ LV + + +G
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRG 176
>BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family
46, subfamily A, polypeptide 1 protein.
Length = 500
Score = 105 bits (251), Expect = 4e-22
Identities = 96/362 (26%), Positives = 161/362 (44%), Gaps = 26/362 (7%)
Query: 71 FTSHWLGDGLITSSG-ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
F G GL++ E W + R++++ AF++ L S + FN+++ +LV EI A G
Sbjct: 116 FGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLV-EILEAKADG 174
Query: 130 --PVEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSF 187
PV + A +L AFG+ QK + KL+ I +N L F
Sbjct: 175 QTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA--KF 232
Query: 188 IYKISGLKKKEEQIVETVHAMSNM---IIKRKREASKNKSPTDEHCYDTTHRYKSIXXXX 244
+ G +K+ ++ E++ + + ++R+REA K T K+
Sbjct: 233 L---PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADIL--TQILKA----- 282
Query: 245 XXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD 304
+ D T +AG++TS+ L +M L PEI ++ EV + G
Sbjct: 283 ----EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG- 337
Query: 305 SEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYG 364
S+ +D L Y+ VLKE+LRLYP R E + + +P ++ + Y
Sbjct: 338 SKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYV 397
Query: 365 LNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLI 424
+ R + D TF P+R+ G P + FS+G R+CIG+ +A M +K + L+
Sbjct: 398 MGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLL 455
Query: 425 RR 426
+R
Sbjct: 456 QR 457
>AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxylase
protein.
Length = 500
Score = 105 bits (251), Expect = 4e-22
Identities = 96/362 (26%), Positives = 161/362 (44%), Gaps = 26/362 (7%)
Query: 71 FTSHWLGDGLITSSG-ETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKG 129
F G GL++ E W + R++++ AF++ L S + FN+++ +LV EI A G
Sbjct: 116 FGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLV-EILEAKADG 174
Query: 130 --PVEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSF 187
PV + A +L AFG+ QK + KL+ I +N L F
Sbjct: 175 QTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA--KF 232
Query: 188 IYKISGLKKKEEQIVETVHAMSNM---IIKRKREASKNKSPTDEHCYDTTHRYKSIXXXX 244
+ G +K+ ++ E++ + + ++R+REA K T K+
Sbjct: 233 L---PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADIL--TQILKA----- 282
Query: 245 XXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD 304
+ D T +AG++TS+ L +M L PEI ++ EV + G
Sbjct: 283 ----EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG- 337
Query: 305 SEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYG 364
S+ +D L Y+ VLKE+LRLYP R E + + +P ++ + Y
Sbjct: 338 SKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYV 397
Query: 365 LNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLI 424
+ R + D TF P+R+ G P + FS+G R+CIG+ +A M +K + L+
Sbjct: 398 MGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLL 455
Query: 425 RR 426
+R
Sbjct: 456 QR 457
>AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 504
Score = 103 bits (246), Expect = 2e-21
Identities = 91/391 (23%), Positives = 167/391 (42%), Gaps = 14/391 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEV 133
+L L + E WKR R LL+PAF + + + LV + E + +
Sbjct: 113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F ++ T FG+ ++ + Q ++ ++ KLL L + +LL + F +
Sbjct: 173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK-LDFLDPFLLLISLFPFLTP 231
Query: 193 GLKKKEEQIV--ETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
+ + + H + N I + K K+K +H D +
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKETKSHK 288
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVD 310
+ + II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V
Sbjct: 289 ALSDLELVAQSI-IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVT 346
Query: 311 KSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPV 370
+ Y++ V+ ETLRL+P+V R + DIE+ IP ++ IY L+ P
Sbjct: 347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406
Query: 371 WGPDAHTFRPE-RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
+ + F PE R+ + D + F G R CIG +AL ++K ++ ++ +
Sbjct: 407 YWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSF 466
Query: 430 -TADISKVEFKMDVL--MTPVNNCNVKFELR 457
+++ K+D L + P +K LR
Sbjct: 467 KPCKETQIPLKLDNLPILQPEKPIVLKVHLR 497
>AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein.
Length = 504
Score = 103 bits (246), Expect = 2e-21
Identities = 91/391 (23%), Positives = 167/391 (42%), Gaps = 14/391 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEV 133
+L L + E WKR R LL+PAF + + + LV + E + +
Sbjct: 113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F ++ T FG+ ++ + Q ++ ++ KLL L + +LL + F +
Sbjct: 173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK-LDFLDPFLLLISLFPFLTP 231
Query: 193 GLKKKEEQIV--ETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
+ + + H + N I + K K+K +H D +
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKETKSHK 288
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVD 310
+ + II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V
Sbjct: 289 ALSDLELVAQSI-IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVT 346
Query: 311 KSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPV 370
+ Y++ V+ ETLRL+P+V R + DIE+ IP ++ IY L+ P
Sbjct: 347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406
Query: 371 WGPDAHTFRPE-RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
+ + F PE R+ + D + F G R CIG +AL ++K ++ ++ +
Sbjct: 407 YWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSF 466
Query: 430 -TADISKVEFKMDVL--MTPVNNCNVKFELR 457
+++ K+D L + P +K LR
Sbjct: 467 KPCKETQIPLKLDNLPILQPEKPIVLKVHLR 497
>AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase
protein.
Length = 531
Score = 99.5 bits (237), Expect = 2e-20
Identities = 67/210 (31%), Positives = 103/210 (49%), Gaps = 11/210 (5%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF--GDSEADVDKSHY 314
E + +++AG DT+S LT + L PEIQ +++EV + G D +H
Sbjct: 324 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQKALHEEVVGVVPAGQVPQHKDFAHM 383
Query: 315 PGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPD 374
P L +AVLKETLRLYP+VP R E +IE+ + P ++ V Y ++R P +
Sbjct: 384 PLL---KAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYEVSRDPTAFSE 440
Query: 375 AHTFRPERWLEPG--GVPDDPNAFAG--FSVGKRTCIGKVYALMSMKTTLVHLIRRYKVT 430
+F+P RWL P + F F G R C+G+ A + M+ L LI++YKV
Sbjct: 441 PESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 500
Query: 431 ADISKVEFK--MDVLMTPVNNCNVKFELRK 458
E K +++ P ++F R+
Sbjct: 501 LAPETGELKSVARIVLVPNKKVGLQFLQRQ 530
>X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase
protein.
Length = 530
Score = 99.1 bits (236), Expect = 3e-20
Identities = 67/210 (31%), Positives = 103/210 (49%), Gaps = 11/210 (5%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF--GDSEADVDKSHY 314
E + +++AG DT+S LT + L PEIQ +++EV + G D +H
Sbjct: 323 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHM 382
Query: 315 PGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPD 374
P L +AVLKETLRLYP+VP R E +IE+ + P ++ V Y ++R P +
Sbjct: 383 PLL---KAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSE 439
Query: 375 AHTFRPERWLEPG--GVPDDPNAFAG--FSVGKRTCIGKVYALMSMKTTLVHLIRRYKVT 430
+F+P RWL P + F F G R C+G+ A + M+ L LI++YKV
Sbjct: 440 PESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 499
Query: 431 ADISKVEFK--MDVLMTPVNNCNVKFELRK 458
E K +++ P ++F R+
Sbjct: 500 LAPETGELKSVARIVLVPNKKVGLQFLQRQ 529
>M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase
protein.
Length = 531
Score = 99.1 bits (236), Expect = 3e-20
Identities = 67/210 (31%), Positives = 103/210 (49%), Gaps = 11/210 (5%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF--GDSEADVDKSHY 314
E + +++AG DT+S LT + L PEIQ +++EV + G D +H
Sbjct: 324 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHM 383
Query: 315 PGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPD 374
P L +AVLKETLRLYP+VP R E +IE+ + P ++ V Y ++R P +
Sbjct: 384 PLL---KAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSE 440
Query: 375 AHTFRPERWLEPG--GVPDDPNAFAG--FSVGKRTCIGKVYALMSMKTTLVHLIRRYKVT 430
+F+P RWL P + F F G R C+G+ A + M+ L LI++YKV
Sbjct: 441 PESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 500
Query: 431 ADISKVEFK--MDVLMTPVNNCNVKFELRK 458
E K +++ P ++F R+
Sbjct: 501 LAPETGELKSVARIVLVPNKKVGLQFLQRQ 530
>BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 99.1 bits (236), Expect = 3e-20
Identities = 67/210 (31%), Positives = 103/210 (49%), Gaps = 11/210 (5%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF--GDSEADVDKSHY 314
E + +++AG DT+S LT + L PEIQ +++EV + G D +H
Sbjct: 324 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHM 383
Query: 315 PGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPD 374
P L +AVLKETLRLYP+VP R E +IE+ + P ++ V Y ++R P +
Sbjct: 384 PLL---KAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSE 440
Query: 375 AHTFRPERWLEPG--GVPDDPNAFAG--FSVGKRTCIGKVYALMSMKTTLVHLIRRYKVT 430
+F+P RWL P + F F G R C+G+ A + M+ L LI++YKV
Sbjct: 441 PESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 500
Query: 431 ADISKVEFK--MDVLMTPVNNCNVKFELRK 458
E K +++ P ++F R+
Sbjct: 501 LAPETGELKSVARIVLVPNKKVGLQFLQRQ 530
>BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 99.1 bits (236), Expect = 3e-20
Identities = 67/210 (31%), Positives = 103/210 (49%), Gaps = 11/210 (5%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMF--GDSEADVDKSHY 314
E + +++AG DT+S LT + L PEIQ +++EV + G D +H
Sbjct: 324 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHM 383
Query: 315 PGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPD 374
P L +AVLKETLRLYP+VP R E +IE+ + P ++ V Y ++R P +
Sbjct: 384 PLL---KAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSE 440
Query: 375 AHTFRPERWLEPG--GVPDDPNAFAG--FSVGKRTCIGKVYALMSMKTTLVHLIRRYKVT 430
+F+P RWL P + F F G R C+G+ A + M+ L LI++YKV
Sbjct: 441 PESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 500
Query: 431 ADISKVEFK--MDVLMTPVNNCNVKFELRK 458
E K +++ P ++F R+
Sbjct: 501 LAPETGELKSVARIVLVPNKKVGLQFLQRQ 530
>AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein.
Length = 353
Score = 98.7 bits (235), Expect = 4e-20
Identities = 51/162 (31%), Positives = 89/162 (54%), Gaps = 1/162 (0%)
Query: 266 IVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLK 325
I AGY+T+S VL+ +M L ++P++Q K+ +E+ ++ ++A + Y++ V+
Sbjct: 153 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVN 211
Query: 326 ETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLE 385
ETLRL+PI R + D+E+ IP ++ Y L+R P + + F PER+ +
Sbjct: 212 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 271
Query: 386 PGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
DP + F G R CIG +ALM+MK L+ +++ +
Sbjct: 272 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 313
>D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV
protein.
Length = 389
Score = 97.9 bits (233), Expect = 7e-20
Identities = 65/266 (24%), Positives = 124/266 (46%), Gaps = 7/266 (2%)
Query: 69 YRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAK 128
Y F WLGDGL+ S+GE W RHR++L PAF+ IL ++ +FN+ + ++ ++
Sbjct: 125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASE 184
Query: 129 GP--VEVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNS 186
G +++ M L F + +YI ++ +L +++ R Q +LL+
Sbjct: 185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYID 244
Query: 187 FIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTD---EHCYDTTHRYKSIXXX 243
F+Y ++ ++ + VH ++ +I+ +R ++ D T + +
Sbjct: 245 FLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV-LL 303
Query: 244 XXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFG 303
+IR E DT + G+DT++ L+ V+ L +PE Q + QEV +
Sbjct: 304 LSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLK 363
Query: 304 DSE-ADVDKSHYPGLVYVEAVLKETL 328
D E +++ L ++ +KE+L
Sbjct: 364 DREPKEIEWDDLAQLPFLTMCIKESL 389
>BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein.
Length = 393
Score = 95.1 bits (226), Expect = 5e-19
Identities = 56/196 (28%), Positives = 99/196 (50%), Gaps = 4/196 (2%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVL 324
II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V + Y++ V+
Sbjct: 192 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVV 250
Query: 325 KETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
ETLRL+P+V R + DIE+ IP ++ IY L+ P + + F PER+
Sbjct: 251 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 310
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV-TADISKVEFKMDVL 443
+ D + F G R CIG +AL ++K ++ ++ + +++ K+D L
Sbjct: 311 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 370
Query: 444 --MTPVNNCNVKFELR 457
+ P +K LR
Sbjct: 371 PILQPEKPIVLKVHLR 386
>BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 89.8 bits (213), Expect = 2e-17
Identities = 92/359 (25%), Positives = 151/359 (42%), Gaps = 22/359 (6%)
Query: 79 GLITSS-GETWKRHRKLLNPAFNQ--QILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVT 134
GL+ S G W HR+L +F SF +E++ I E KG P +
Sbjct: 123 GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI--ETYKGRPFDFK 180
Query: 135 TPFRQMAFRLLFLTAFG--IPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
+ L FG ED+DF Q I + + + +V L+N+F +
Sbjct: 181 QLITNAVSNITNLIIFGERFTYEDTDF-QHMIELFSENVELAASA--SVFLYNAFPWIGI 237
Query: 193 GLKKKEEQIVETVHAMSNMIIKRKREASKNKSPT-DEHCYDTTHRYKSIXXXXXXXXXXX 251
K +Q+ + + + + +AS N+ P +H D Y
Sbjct: 238 LPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDA---YLD-EMDQGKNDPSS 293
Query: 252 XXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV-- 309
+ V +I+AG +T++ VL ++ + YP IQ +V +E+ + G +
Sbjct: 294 TFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWD 353
Query: 310 DKSHYPGLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRH 368
DK P Y EAVL E LR IVP+ + T D ++ Y+IP + + +Y ++
Sbjct: 354 DKCKMP---YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410
Query: 369 PVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ D F PER+L+ G A FS+G+R C+G+ A M M L++R+
Sbjct: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469
>BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 89.8 bits (213), Expect = 2e-17
Identities = 92/359 (25%), Positives = 151/359 (42%), Gaps = 22/359 (6%)
Query: 79 GLITSS-GETWKRHRKLLNPAFNQ--QILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVT 134
GL+ S G W HR+L +F SF +E++ I E KG P +
Sbjct: 123 GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI--ETYKGRPFDFK 180
Query: 135 TPFRQMAFRLLFLTAFG--IPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
+ L FG ED+DF Q I + + + +V L+N+F +
Sbjct: 181 QLITNAVSNITNLIIFGERFTYEDTDF-QHMIELFSENVELAASA--SVFLYNAFPWIGI 237
Query: 193 GLKKKEEQIVETVHAMSNMIIKRKREASKNKSPT-DEHCYDTTHRYKSIXXXXXXXXXXX 251
K +Q+ + + + + +AS N+ P +H D Y
Sbjct: 238 LPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDA---YLD-EMDQGKNDPSS 293
Query: 252 XXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV-- 309
+ V +I+AG +T++ VL ++ + YP IQ +V +E+ + G +
Sbjct: 294 TFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWD 353
Query: 310 DKSHYPGLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRH 368
DK P Y EAVL E LR IVP+ + T D ++ Y+IP + + +Y ++
Sbjct: 354 DKCKMP---YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410
Query: 369 PVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ D F PER+L+ G A FS+G+R C+G+ A M M L++R+
Sbjct: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469
>AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1
protein.
Length = 501
Score = 89.8 bits (213), Expect = 2e-17
Identities = 92/359 (25%), Positives = 151/359 (42%), Gaps = 22/359 (6%)
Query: 79 GLITSS-GETWKRHRKLLNPAFNQ--QILNSFIGVFNDESRKLVSEIGNEMAKG-PVEVT 134
GL+ S G W HR+L +F SF +E++ I E KG P +
Sbjct: 123 GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI--ETYKGRPFDFK 180
Query: 135 TPFRQMAFRLLFLTAFG--IPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
+ L FG ED+DF Q I + + + +V L+N+F +
Sbjct: 181 QLITNAVSNITNLIIFGERFTYEDTDF-QHMIELFSENVELAASA--SVFLYNAFPWIGI 237
Query: 193 GLKKKEEQIVETVHAMSNMIIKRKREASKNKSPT-DEHCYDTTHRYKSIXXXXXXXXXXX 251
K +Q+ + + + + +AS N+ P +H D Y
Sbjct: 238 LPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDA---YLD-EMDQGKNDPSS 293
Query: 252 XXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV-- 309
+ V +I+AG +T++ VL ++ + YP IQ +V +E+ + G +
Sbjct: 294 TFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWD 353
Query: 310 DKSHYPGLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRH 368
DK P Y EAVL E LR IVP+ + T D ++ Y+IP + + +Y ++
Sbjct: 354 DKCKMP---YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410
Query: 369 PVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+ D F PER+L+ G A FS+G+R C+G+ A M M L++R+
Sbjct: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469
>U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450
monooxygenase CYP2J2 protein.
Length = 502
Score = 89.0 bits (211), Expect = 3e-17
Identities = 84/380 (22%), Positives = 154/380 (40%), Gaps = 17/380 (4%)
Query: 78 DGLITSSGETWKRHRKLLNPAFNQQILN--SFIGVFNDESRKLVSEIGNEMAKGPVEVTT 135
+GLI SSG+ WK R+ A L S +E++ L I E + P +
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQ-PFDPHF 182
Query: 136 PFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIY--RFQNVLLHNSFIYKISG 193
++ FG E ++ + + KLL + Y + L+N F + +
Sbjct: 183 KINNAVSNIICSITFG---ERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKF 239
Query: 194 LKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXX 253
L + + + + + K+ +P + D Y
Sbjct: 240 LPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETR--DFIDAYLKEMSKHTGNPTSSFH 297
Query: 254 XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSH 313
I +D + AG +T+S L ++ + YPEIQ KV E+ + G + +
Sbjct: 298 EENLICSTLD-LFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356
Query: 314 YPGLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWG 372
+ Y AV+ E R+ I+P+ + R+ D L Y +P + + + L+R P
Sbjct: 357 -ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEW 415
Query: 373 PDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD 432
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 416 ATPDTFNPDHFLENGQF-KKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPP 474
Query: 433 ISK---VEFKMDVLMTPVNN 449
++ ++F+M + ++PV++
Sbjct: 475 NNEKLSLKFRMGITISPVSH 494
>BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 89.0 bits (211), Expect = 3e-17
Identities = 84/380 (22%), Positives = 154/380 (40%), Gaps = 17/380 (4%)
Query: 78 DGLITSSGETWKRHRKLLNPAFNQQILN--SFIGVFNDESRKLVSEIGNEMAKGPVEVTT 135
+GLI SSG+ WK R+ A L S +E++ L I E + P +
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQ-PFDPHF 182
Query: 136 PFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIY--RFQNVLLHNSFIYKISG 193
++ FG E ++ + + KLL + Y + L+N F + +
Sbjct: 183 KINNAVSNIICSITFG---ERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKF 239
Query: 194 LKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXX 253
L + + + + + K+ +P + D Y
Sbjct: 240 LPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETR--DFIDAYLKEMSKHTGNPTSSFH 297
Query: 254 XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSH 313
I +D + AG +T+S L ++ + YPEIQ KV E+ + G + +
Sbjct: 298 EENLICSTLD-LFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356
Query: 314 YPGLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWG 372
+ Y AV+ E R+ I+P+ + R+ D L Y +P + + + L+R P
Sbjct: 357 -ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEW 415
Query: 373 PDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD 432
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 416 ATPDTFNPDHFLENGQF-KKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPP 474
Query: 433 ISK---VEFKMDVLMTPVNN 449
++ ++F+M + ++PV++
Sbjct: 475 NNEKLSLKFRMGITISPVSH 494
>AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 89.0 bits (211), Expect = 3e-17
Identities = 84/380 (22%), Positives = 154/380 (40%), Gaps = 17/380 (4%)
Query: 78 DGLITSSGETWKRHRKLLNPAFNQQILN--SFIGVFNDESRKLVSEIGNEMAKGPVEVTT 135
+GLI SSG+ WK R+ A L S +E++ L I E + P +
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQ-PFDPHF 182
Query: 136 PFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIY--RFQNVLLHNSFIYKISG 193
++ FG E ++ + + KLL + Y + L+N F + +
Sbjct: 183 KINNAVSNIICSITFG---ERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKF 239
Query: 194 LKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXX 253
L + + + + + K+ +P + D Y
Sbjct: 240 LPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETR--DFIDAYLKEMSKHTGNPTSSFH 297
Query: 254 XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSH 313
I +D + AG +T+S L ++ + YPEIQ KV E+ + G + +
Sbjct: 298 EENLICSTLD-LFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356
Query: 314 YPGLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWG 372
+ Y AV+ E R+ I+P+ + R+ D L Y +P + + + L+R P
Sbjct: 357 -ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEW 415
Query: 373 PDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD 432
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 416 ATPDTFNPDHFLENGQF-KKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPP 474
Query: 433 ISK---VEFKMDVLMTPVNN 449
++ ++F+M + ++PV++
Sbjct: 475 NNEKLSLKFRMGITISPVSH 494
>AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein.
Length = 502
Score = 89.0 bits (211), Expect = 3e-17
Identities = 84/380 (22%), Positives = 154/380 (40%), Gaps = 17/380 (4%)
Query: 78 DGLITSSGETWKRHRKLLNPAFNQQILN--SFIGVFNDESRKLVSEIGNEMAKGPVEVTT 135
+GLI SSG+ WK R+ A L S +E++ L I E + P +
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQ-PFDPHF 182
Query: 136 PFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIY--RFQNVLLHNSFIYKISG 193
++ FG E ++ + + KLL + Y + L+N F + +
Sbjct: 183 KINNAVSNIICSITFG---ERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKF 239
Query: 194 LKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXX 253
L + + + + + K+ +P + D Y
Sbjct: 240 LPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETR--DFIDAYLKEMSKHTGNPTSSFH 297
Query: 254 XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSH 313
I +D + AG +T+S L ++ + YPEIQ KV E+ + G + +
Sbjct: 298 EENLICSTLD-LFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356
Query: 314 YPGLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWG 372
+ Y AV+ E R+ I+P+ + R+ D L Y +P + + + L+R P
Sbjct: 357 -ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEW 415
Query: 373 PDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD 432
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 416 ATPDTFNPDHFLENGQF-KKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPP 474
Query: 433 ISK---VEFKMDVLMTPVNN 449
++ ++F+M + ++PV++
Sbjct: 475 NNEKLSLKFRMGITISPVSH 494
>AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2
protein.
Length = 502
Score = 88.6 bits (210), Expect = 4e-17
Identities = 84/380 (22%), Positives = 154/380 (40%), Gaps = 17/380 (4%)
Query: 78 DGLITSSGETWKRHRKLLNPAFNQQILN--SFIGVFNDESRKLVSEIGNEMAKGPVEVTT 135
+GLI SSG+ WK R+ A L S +E++ L I E + P +
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQ-PFDPHF 182
Query: 136 PFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIY--RFQNVLLHNSFIYKISG 193
++ FG E ++ + + KLL + Y + L+N F + +
Sbjct: 183 KINNAVSNIICSITFG---ERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKF 239
Query: 194 LKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXX 253
L + + + + + K+ +P + D Y
Sbjct: 240 LPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETR--DFIDAYLKEMSKHTGNPTSSFH 297
Query: 254 XXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSH 313
I +D + AG +T+S L ++ + YPEIQ KV E+ + G + +
Sbjct: 298 EENLICSTLD-LFFAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQPSTAAR 356
Query: 314 YPGLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWG 372
+ Y AV+ E R+ I+P+ + R+ D L Y +P + + + L+R P
Sbjct: 357 -ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEW 415
Query: 373 PDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD 432
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 416 ATPDTFNPDHFLENGQF-KKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPP 474
Query: 433 ISK---VEFKMDVLMTPVNN 449
++ ++F+M + ++PV++
Sbjct: 475 NNEKLSLKFRMGITISPVSH 494
>AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 420
Score = 88.2 bits (209), Expect = 5e-17
Identities = 74/312 (23%), Positives = 133/312 (42%), Gaps = 10/312 (3%)
Query: 75 WLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGP-VEV 133
+L L + E WKR R LL+PAF + + + LV + E + +
Sbjct: 113 FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINL 172
Query: 134 TTPFRQMAFRLLFLTAFGIPVEDSDFNQK-YIHSVDKLLSMLIYRFQNVLLHNSFIYKIS 192
F ++ T FG+ ++ + Q ++ ++ KLL L + +LL + F +
Sbjct: 173 KDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK-LDFLDPFLLLISLFPFLTP 231
Query: 193 GLKKKEEQIV--ETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
+ + + H + N I + K K+K +H D +
Sbjct: 232 VFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKETKSHK 288
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVD 310
+ + II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V
Sbjct: 289 ALSDLELVAQSI-IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVT 346
Query: 311 KSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPV 370
+ Y++ V+ ETLRL+P+V R + DIE+ IP ++ IY L+ P
Sbjct: 347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPK 406
Query: 371 WGPDAHTFRPER 382
+ + F PER
Sbjct: 407 YWTEPEKFCPER 418
>AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.8 bits (208), Expect = 7e-17
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.4 bits (207), Expect = 9e-17
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYVLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase
protein.
Length = 533
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 330 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 389
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 390 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 449
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 450 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVHLGLLEVKLTLLHVLHKFRFQA 504
>BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A)
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein.
Length = 466
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 263 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 322
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 323 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 382
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 383 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 437
>AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A) iso
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAEDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 87.0 bits (206), Expect = 1e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 86.6 bits (205), Expect = 2e-16
Identities = 50/175 (28%), Positives = 82/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPK 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
TF PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 85.0 bits (201), Expect = 5e-16
Identities = 49/175 (28%), Positives = 81/175 (46%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
EI + ++AGY+ + L+ L + P+ Q K+ +EV A S G
Sbjct: 331 EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG 390
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L Y++ V+ ETLR+YP R+ D E+ IPA + + + L+ P P
Sbjct: 391 LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE 450
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA 431
F PER+ P + F G R+C+G L+ +K TL+H++ +++ A
Sbjct: 451 NFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
>AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens
cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to
CYTOCHROME P450 4A1 (EC 1.14.15.3). ).
Length = 340
Score = 84.2 bits (199), Expect = 9e-16
Identities = 57/232 (24%), Positives = 105/232 (45%), Gaps = 11/232 (4%)
Query: 68 AYRFTSHWLGDGLITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMA 127
+++ W+G GL+T G WK+HR+++ P FN IL FI + + R ++++ +A
Sbjct: 113 SHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSKSVRMMLNKWEEHIA 172
Query: 128 KGP-VEVTTPFRQMAFRLLFLTAF---GIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLL 183
+ +E+ M + AF G DS + Y+ +V L + R N L
Sbjct: 173 QNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLD-SYLKAVFNLSKISNQRMNNFLH 231
Query: 184 HNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXX 243
HN ++K S + + + +H + +I+ ++E+ K+K D T R +
Sbjct: 232 HNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQD----TTQKRRQDFLDI 287
Query: 244 XXXXXXXXXXXXXE--IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNK 293
E ++ EV T + AG+DT++ ++ + L YPE Q +
Sbjct: 288 LLSAKSENTKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQR 339
>L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3
24-hydroxylase protein.
Length = 513
Score = 83.8 bits (198), Expect = 1e-15
Identities = 55/199 (27%), Positives = 95/199 (47%), Gaps = 3/199 (1%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
E+ V + +A +T++ L ++ L P++Q K+ +E+ S+ +++ ++
Sbjct: 314 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQRPREED-LRN 372
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ Y++A LKE++RL P VP R + L Y +P + +L L D+
Sbjct: 373 MPYLKACLKESMRLTPGVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 432
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA-DISK 435
FRPERWL+ +P A F VGKR CIG+ A + + L ++R+Y + A D
Sbjct: 433 QFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 491
Query: 436 VEFKMDVLMTPVNNCNVKF 454
VE + P + F
Sbjct: 492 VEMLHSGTLVPSRELPIAF 510
>BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family 2,
subfamily U, polypeptide 1 protein.
Length = 544
Score = 83.8 bits (198), Expect = 1e-15
Identities = 48/169 (28%), Positives = 85/169 (50%), Gaps = 6/169 (3%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEAD--VDKSHYPGLVY 319
+ + +AG DT++ L ++ + P++Q KV++E+ + G + A DK+ P Y
Sbjct: 346 IGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMP---Y 402
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTF 378
EA + E RL +VP+A+ T + L+ YTIP + + ++ ++R P F
Sbjct: 403 TEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDF 462
Query: 379 RPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P R+L+ G F F +GKR C+G+ A M + V L++ +
Sbjct: 463 YPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
>AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein.
Length = 544
Score = 83.8 bits (198), Expect = 1e-15
Identities = 48/169 (28%), Positives = 85/169 (50%), Gaps = 6/169 (3%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEAD--VDKSHYPGLVY 319
+ + +AG DT++ L ++ + P++Q KV++E+ + G + A DK+ P Y
Sbjct: 346 IGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMP---Y 402
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTF 378
EA + E RL +VP+A+ T + L+ YTIP + + ++ ++R P F
Sbjct: 403 TEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDF 462
Query: 379 RPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P R+L+ G F F +GKR C+G+ A M + V L++ +
Sbjct: 463 YPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
>AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylase
splice variant protein.
Length = 372
Score = 83.4 bits (197), Expect = 2e-15
Identities = 55/199 (27%), Positives = 94/199 (47%), Gaps = 3/199 (1%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
E+ V + +A +T++ L ++ L P++Q K+ +E+ S+ +++ +
Sbjct: 173 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED-LRN 231
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ Y++A LKE++RL P VP R + L Y +P + +L L D+
Sbjct: 232 MPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 291
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA-DISK 435
FRPERWL+ +P A F VGKR CIG+ A + + L ++R+Y + A D
Sbjct: 292 QFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 350
Query: 436 VEFKMDVLMTPVNNCNVKF 454
VE + P + F
Sbjct: 351 VEMLHSGTLVPSRELPIAF 369
>AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 514
Score = 83.4 bits (197), Expect = 2e-15
Identities = 55/199 (27%), Positives = 94/199 (47%), Gaps = 3/199 (1%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
E+ V + +A +T++ L ++ L P++Q K+ +E+ S+ +++ +
Sbjct: 315 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED-LRN 373
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ Y++A LKE++RL P VP R + L Y +P + +L L D+
Sbjct: 374 MPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 433
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA-DISK 435
FRPERWL+ +P A F VGKR CIG+ A + + L ++R+Y + A D
Sbjct: 434 QFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 492
Query: 436 VEFKMDVLMTPVNNCNVKF 454
VE + P + F
Sbjct: 493 VEMLHSGTLVPSRELPIAF 511
>AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 372
Score = 83.4 bits (197), Expect = 2e-15
Identities = 55/199 (27%), Positives = 94/199 (47%), Gaps = 3/199 (1%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
E+ V + +A +T++ L ++ L P++Q K+ +E+ S+ +++ +
Sbjct: 173 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED-LRN 231
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ Y++A LKE++RL P VP R + L Y +P + +L L D+
Sbjct: 232 MPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 291
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA-DISK 435
FRPERWL+ +P A F VGKR CIG+ A + + L ++R+Y + A D
Sbjct: 292 QFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 350
Query: 436 VEFKMDVLMTPVNNCNVKF 454
VE + P + F
Sbjct: 351 VEMLHSGTLVPSRELPIAF 369
>S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D
24-hydroxylase cytochrome P450 subunit protein.
Length = 257
Score = 82.2 bits (194), Expect = 3e-15
Identities = 54/191 (28%), Positives = 92/191 (48%), Gaps = 3/191 (1%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
E+ V + +A +T++ L ++ L P++Q K+ +E+ S+ +++ +
Sbjct: 58 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAED-LRN 116
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ Y++A LKE++RL P VP R + L Y +P + +L L D+
Sbjct: 117 MPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 176
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTA-DISK 435
FRPERWL+ +P A F VGKR CIG+ A + + L ++R+Y + A D
Sbjct: 177 QFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 235
Query: 436 VEFKMDVLMTP 446
VE + P
Sbjct: 236 VEMLHSGTLVP 246
>M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein.
Length = 370
Score = 80.2 bits (189), Expect = 1e-14
Identities = 52/185 (28%), Positives = 90/185 (48%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L +PE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 177 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRSHMP---YTDAVVH 233
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P +L + D++ +NY IP + + + + P+ F P +L
Sbjct: 234 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 293
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ GG N F FS GKR C+G+ A M + L +++ + + + I D+
Sbjct: 294 DEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID----PKDLDT 349
Query: 445 TPVNN 449
TPV N
Sbjct: 350 TPVVN 354
>AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 variant protein.
Length = 490
Score = 80.2 bits (189), Expect = 1e-14
Identities = 54/185 (29%), Positives = 93/185 (50%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L YPE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 297 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP---YTDAVVH 353
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P L + D++ KNY IP + + + + + P+ F P +L
Sbjct: 354 EIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ G + F FS GKR C+G+ A M + L +++ + + SKV+ K D+ +
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SKVDPK-DIDI 469
Query: 445 TPVNN 449
TP+ N
Sbjct: 470 TPIAN 474
>S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein.
Length = 477
Score = 79.8 bits (188), Expect = 2e-14
Identities = 77/362 (21%), Positives = 155/362 (42%), Gaps = 21/362 (5%)
Query: 77 GDGLITSSGETWKRHRK-----LLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPV 131
G G++ S+G+ WK R+ L N ++ + + +E+R LV E+ A P
Sbjct: 96 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKAS-PC 151
Query: 132 EVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSML-IYRFQNVLLHNSFIYK 190
+ T ++ F + D Q++++ ++KL + I + + N+F
Sbjct: 152 DPTFILGCAPCNVICSIIFHKRFDYKD--QQFLNLMEKLNENIKILSSPWIQICNNFSPI 209
Query: 191 ISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
I ++++ V M + I+++ +E ++ + + K
Sbjct: 210 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM---EKEKHNQP 266
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV- 309
+ + + AG +T+S L ++ L +PE+ KV +E+ + G + +
Sbjct: 267 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 326
Query: 310 -DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNR 367
D+SH P Y +AV+ E R ++P +L + DI+ +NY IP + ++ + +
Sbjct: 327 QDRSHMP---YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 383
Query: 368 HPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P+ F P +L+ GG F FS GKR C+G+ A M + L +++ +
Sbjct: 384 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 443
Query: 428 KV 429
+
Sbjct: 444 NL 445
>M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein.
Length = 383
Score = 79.8 bits (188), Expect = 2e-14
Identities = 77/362 (21%), Positives = 155/362 (42%), Gaps = 21/362 (5%)
Query: 77 GDGLITSSGETWKRHRK-----LLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPV 131
G G++ S+G+ WK R+ L N ++ + + +E+R LV E+ A P
Sbjct: 2 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKAS-PC 57
Query: 132 EVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSML-IYRFQNVLLHNSFIYK 190
+ T ++ F + D Q++++ ++KL + I + + N+F
Sbjct: 58 DPTFILGCAPCNVICSIIFHKRFDYKD--QQFLNLMEKLNENIKILSSPWIQICNNFSPI 115
Query: 191 ISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
I ++++ V M + I+++ +E ++ + + K
Sbjct: 116 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM---EKEKHNQP 172
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV- 309
+ + + AG +T+S L ++ L +PE+ KV +E+ + G + +
Sbjct: 173 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 232
Query: 310 -DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNR 367
D+SH P Y +AV+ E R ++P +L + DI+ +NY IP + ++ + +
Sbjct: 233 QDRSHMP---YTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 289
Query: 368 HPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P+ F P +L+ GG F FS GKR C+G+ A M + L +++ +
Sbjct: 290 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 349
Query: 428 KV 429
+
Sbjct: 350 NL 351
>D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein.
Length = 487
Score = 79.8 bits (188), Expect = 2e-14
Identities = 77/362 (21%), Positives = 155/362 (42%), Gaps = 21/362 (5%)
Query: 77 GDGLITSSGETWKRHRK-----LLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPV 131
G G++ S+G+ WK R+ L N ++ + + +E+R LV E+ A P
Sbjct: 106 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKAS-PC 161
Query: 132 EVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSML-IYRFQNVLLHNSFIYK 190
+ T ++ F + D Q++++ ++KL + I + + N+F
Sbjct: 162 DPTFILGCAPCNVICSIIFHKRFDYKD--QQFLNLMEKLNENIKILSSPWIQICNNFSPI 219
Query: 191 ISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
I ++++ V M + I+++ +E ++ + + K
Sbjct: 220 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM---EKEKHNQP 276
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV- 309
+ + + AG +T+S L ++ L +PE+ KV +E+ + G + +
Sbjct: 277 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 336
Query: 310 -DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNR 367
D+SH P Y +AV+ E R ++P +L + DI+ +NY IP + ++ + +
Sbjct: 337 QDRSHMP---YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 393
Query: 368 HPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P+ F P +L+ GG F FS GKR C+G+ A M + L +++ +
Sbjct: 394 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 453
Query: 428 KV 429
+
Sbjct: 454 NL 455
>BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 79.8 bits (188), Expect = 2e-14
Identities = 77/362 (21%), Positives = 155/362 (42%), Gaps = 21/362 (5%)
Query: 77 GDGLITSSGETWKRHRK-----LLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPV 131
G G++ S+G+ WK R+ L N ++ + + +E+R LV E+ A P
Sbjct: 109 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKAS-PC 164
Query: 132 EVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSML-IYRFQNVLLHNSFIYK 190
+ T ++ F + D Q++++ ++KL + I + + N+F
Sbjct: 165 DPTFILGCAPCNVICSIIFHKRFDYKD--QQFLNLMEKLNENIKILSSPWIQICNNFSPI 222
Query: 191 ISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
I ++++ V M + I+++ +E ++ + + K
Sbjct: 223 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM---EKEKHNQP 279
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV- 309
+ + + AG +T+S L ++ L +PE+ KV +E+ + G + +
Sbjct: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339
Query: 310 -DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNR 367
D+SH P Y +AV+ E R ++P +L + DI+ +NY IP + ++ + +
Sbjct: 340 QDRSHMP---YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 396
Query: 368 HPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P+ F P +L+ GG F FS GKR C+G+ A M + L +++ +
Sbjct: 397 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456
Query: 428 KV 429
+
Sbjct: 457 NL 458
>BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 79.8 bits (188), Expect = 2e-14
Identities = 79/353 (22%), Positives = 147/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 190
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ + IP+++S K D +Q +L+ +KIS L K
Sbjct: 191 LRRVMLDTSNMLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 242
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 243 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 294
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 352
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 411
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 412 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 79.8 bits (188), Expect = 2e-14
Identities = 77/362 (21%), Positives = 155/362 (42%), Gaps = 21/362 (5%)
Query: 77 GDGLITSSGETWKRHRK-----LLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPV 131
G G++ S+G+ WK R+ L N ++ + + +E+R LV E+ A P
Sbjct: 109 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKAS-PC 164
Query: 132 EVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSML-IYRFQNVLLHNSFIYK 190
+ T ++ F + D Q++++ ++KL + I + + N+F
Sbjct: 165 DPTFILGCAPCNVICSIIFHKRFDYKD--QQFLNLMEKLNENIKILSSPWIQICNNFSPI 222
Query: 191 ISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
I ++++ V M + I+++ +E ++ + + K
Sbjct: 223 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM---EKEKHNQP 279
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV- 309
+ + + AG +T+S L ++ L +PE+ KV +E+ + G + +
Sbjct: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339
Query: 310 -DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNR 367
D+SH P Y +AV+ E R ++P +L + DI+ +NY IP + ++ + +
Sbjct: 340 QDRSHMP---YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 396
Query: 368 HPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P+ F P +L+ GG F FS GKR C+G+ A M + L +++ +
Sbjct: 397 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456
Query: 428 KV 429
+
Sbjct: 457 NL 458
>AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 79.8 bits (188), Expect = 2e-14
Identities = 77/362 (21%), Positives = 155/362 (42%), Gaps = 21/362 (5%)
Query: 77 GDGLITSSGETWKRHRK-----LLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPV 131
G G++ S+G+ WK R+ L N ++ + + +E+R LV E+ A P
Sbjct: 109 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKAS-PC 164
Query: 132 EVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSML-IYRFQNVLLHNSFIYK 190
+ T ++ F + D Q++++ ++KL + I + + N+F
Sbjct: 165 DPTFILGCAPCNVICSIIFHKRFDYKD--QQFLNLMEKLNENIKILSSPWIQICNNFSPI 222
Query: 191 ISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
I ++++ V M + I+++ +E ++ + + K
Sbjct: 223 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM---EKEKHNQP 279
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV- 309
+ + + AG +T+S L ++ L +PE+ KV +E+ + G + +
Sbjct: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339
Query: 310 -DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNR 367
D+SH P Y +AV+ E R ++P +L + DI+ +NY IP + ++ + +
Sbjct: 340 QDRSHMP---YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 396
Query: 368 HPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P+ F P +L+ GG F FS GKR C+G+ A M + L +++ +
Sbjct: 397 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456
Query: 428 KV 429
+
Sbjct: 457 NL 458
>AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 79.8 bits (188), Expect = 2e-14
Identities = 77/362 (21%), Positives = 155/362 (42%), Gaps = 21/362 (5%)
Query: 77 GDGLITSSGETWKRHRK-----LLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPV 131
G G++ S+G+ WK R+ L N ++ + + +E+R LV E+ A P
Sbjct: 109 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKAS-PC 164
Query: 132 EVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSML-IYRFQNVLLHNSFIYK 190
+ T ++ F + D Q++++ ++KL + I + + N+F
Sbjct: 165 DPTFILGCAPCNVICSIIFHKRFDYKD--QQFLNLMEKLNENIKILSSPWIQICNNFSPI 222
Query: 191 ISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
I ++++ V M + I+++ +E ++ + + K
Sbjct: 223 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM---EKEKHNQP 279
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV- 309
+ + + AG +T+S L ++ L +PE+ KV +E+ + G + +
Sbjct: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339
Query: 310 -DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNR 367
D+SH P Y +AV+ E R ++P +L + DI+ +NY IP + ++ + +
Sbjct: 340 QDRSHMP---YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 396
Query: 368 HPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P+ F P +L+ GG F FS GKR C+G+ A M + L +++ +
Sbjct: 397 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456
Query: 428 KV 429
+
Sbjct: 457 NL 458
>X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C
protein.
Length = 356
Score = 79.4 bits (187), Expect = 2e-14
Identities = 52/188 (27%), Positives = 91/188 (48%), Gaps = 10/188 (5%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEA 322
++ AG +T+S L ++ L +PE+ KV +E+ + G + + D+ H P Y +A
Sbjct: 160 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMP---YTDA 216
Query: 323 VLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ E R ++P +L + DI+ +NY IP + + + + P+ F P
Sbjct: 217 VVHEVQRYIDLIPTSLPHAVTCDIKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 276
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMD 441
+L+ GG N F FS GKR C+G+ A M + L +++ + + + I D
Sbjct: 277 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID----PKD 332
Query: 442 VLMTPVNN 449
+ TPV N
Sbjct: 333 LDTTPVVN 340
>M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 79.4 bits (187), Expect = 2e-14
Identities = 51/188 (27%), Positives = 91/188 (48%), Gaps = 10/188 (5%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEA 322
++ AG +T+S L ++ L +PE+ KV +E+ + G + + D+ H P Y +A
Sbjct: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMP---YTDA 350
Query: 323 VLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ E R ++P +L + D++ +NY IP + + + + P+ F P
Sbjct: 351 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 410
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMD 441
+L+ GG N F FS GKR C+G+ A M + L +++ + + + I D
Sbjct: 411 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID----PKD 466
Query: 442 VLMTPVNN 449
+ TPV N
Sbjct: 467 LDTTPVVN 474
>L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxylase
protein.
Length = 217
Score = 79.4 bits (187), Expect = 2e-14
Identities = 51/188 (27%), Positives = 91/188 (48%), Gaps = 10/188 (5%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEA 322
++ AG +T+S L ++ L +PE+ KV +E+ + G + + D+ H P Y +A
Sbjct: 21 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMP---YTDA 77
Query: 323 VLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ E R ++P +L + D++ +NY IP + + + + P+ F P
Sbjct: 78 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 137
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMD 441
+L+ GG N F FS GKR C+G+ A M + L +++ + + + I D
Sbjct: 138 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID----PKD 193
Query: 442 VLMTPVNN 449
+ TPV N
Sbjct: 194 LDTTPVVN 201
>X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (11 Beta). ).
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 53/171 (30%), Positives = 84/171 (49%), Gaps = 5/171 (2%)
Query: 271 DTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRL 330
DT+ + L + + L P +Q + QE S S ++ + L + A LKETLRL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 331 YPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVP 390
YP+ R SD+ L+NY IPA + + +Y L R+P P + P+RWL+ G
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 433
Query: 391 DDPNAF-AGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKM 440
N + F G R C+G+ A M L H+++ +V +++ + KM
Sbjct: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET-LTQEDIKM 483
>M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid
11-beta-hydroxylase-like-enzyme (CYP11B2) gene, exon 9.
).
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 50/170 (29%), Positives = 87/170 (51%), Gaps = 3/170 (1%)
Query: 271 DTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRL 330
DT+++ L + + L P++Q ++ ++ S S ++ + L + A LKETLRL
Sbjct: 317 DTTAFPLLMTLFELARNPDVQ-QILRKESLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 331 YPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVP 390
YP+ R SD+ L+NY IPA + + +Y L R+ P + P+RWL+ G
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435
Query: 391 DDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKM 440
+ + F G R C+G+ A M L H+++R+ V +++ + KM
Sbjct: 436 RNLH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKRFLVET-LTQEDIKM 483
>M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 53/171 (30%), Positives = 84/171 (49%), Gaps = 5/171 (2%)
Query: 271 DTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRL 330
DT+ + L + + L P +Q + QE S S ++ + L + A LKETLRL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 331 YPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVP 390
YP+ R SD+ L+NY IPA + + +Y L R+P P + P+RWL+ G
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 433
Query: 391 DDPNAF-AGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKM 440
N + F G R C+G+ A M L H+++ +V +++ + KM
Sbjct: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET-LTQEDIKM 483
>L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein.
Length = 468
Score = 79.0 bits (186), Expect = 3e-14
Identities = 51/188 (27%), Positives = 91/188 (48%), Gaps = 10/188 (5%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEA 322
++ AG +T+S L ++ L +PE+ KV +E+ + G + + D+ H P Y +A
Sbjct: 272 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMP---YTDA 328
Query: 323 VLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ E R ++P +L + D++ +NY IP + + + + P+ F P
Sbjct: 329 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 388
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMD 441
+L+ GG N F FS GKR C+G+ A M + L +++ + + + I D
Sbjct: 389 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID----PKD 444
Query: 442 VLMTPVNN 449
+ TPV N
Sbjct: 445 LDTTPVVN 452
>BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family
11, subfamily B, polypeptide 1 protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 53/171 (30%), Positives = 84/171 (49%), Gaps = 5/171 (2%)
Query: 271 DTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRL 330
DT+ + L + + L P +Q + QE S S ++ + L + A LKETLRL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 331 YPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVP 390
YP+ R SD+ L+NY IPA + + +Y L R+P P + P+RWL+ G
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 433
Query: 391 DDPNAF-AGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKM 440
N + F G R C+G+ A M L H+++ +V +++ + KM
Sbjct: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET-LTQEDIKM 483
>BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein.
Length = 574
Score = 79.0 bits (186), Expect = 3e-14
Identities = 53/171 (30%), Positives = 84/171 (49%), Gaps = 5/171 (2%)
Query: 271 DTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRL 330
DT+ + L + + L P +Q + QE S S ++ + L + A LKETLRL
Sbjct: 388 DTTVFPLLMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRL 446
Query: 331 YPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVP 390
YP+ R SD+ L+NY IPA + + +Y L R+P P + P+RWL+ G
Sbjct: 447 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 504
Query: 391 DDPNAF-AGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKM 440
N + F G R C+G+ A M L H+++ +V +++ + KM
Sbjct: 505 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET-LTQEDIKM 554
>AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 79.0 bits (186), Expect = 3e-14
Identities = 51/188 (27%), Positives = 91/188 (48%), Gaps = 10/188 (5%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEA 322
++ AG +T+S L ++ L +PE+ KV +E+ + G + + D+ H P Y +A
Sbjct: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMP---YTDA 350
Query: 323 VLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ E R ++P +L + D++ +NY IP + + + + P+ F P
Sbjct: 351 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 410
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMD 441
+L+ GG N F FS GKR C+G+ A M + L +++ + + + I D
Sbjct: 411 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID----PKD 466
Query: 442 VLMTPVNN 449
+ TPV N
Sbjct: 467 LDTTPVVN 474
>AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 79.0 bits (186), Expect = 3e-14
Identities = 51/188 (27%), Positives = 91/188 (48%), Gaps = 10/188 (5%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEA 322
++ AG +T+S L ++ L +PE+ KV +E+ + G + + D+ H P Y +A
Sbjct: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMP---YTDA 350
Query: 323 VLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ E R ++P +L + D++ +NY IP + + + + P+ F P
Sbjct: 351 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 410
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMD 441
+L+ GG N F FS GKR C+G+ A M + L +++ + + + I D
Sbjct: 411 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID----PKD 466
Query: 442 VLMTPVNN 449
+ TPV N
Sbjct: 467 LDTTPVVN 474
>AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 19 protein.
Length = 490
Score = 79.0 bits (186), Expect = 3e-14
Identities = 51/188 (27%), Positives = 91/188 (48%), Gaps = 10/188 (5%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEA 322
++ AG +T+S L ++ L +PE+ KV +E+ + G + + D+ H P Y +A
Sbjct: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMP---YTDA 350
Query: 323 VLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPE 381
V+ E R ++P +L + D++ +NY IP + + + + P+ F P
Sbjct: 351 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 410
Query: 382 RWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMD 441
+L+ GG N F FS GKR C+G+ A M + L +++ + + + I D
Sbjct: 411 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID----PKD 466
Query: 442 VLMTPVNN 449
+ TPV N
Sbjct: 467 LDTTPVVN 474
>AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome
P-450c11 protein protein.
Length = 503
Score = 79.0 bits (186), Expect = 3e-14
Identities = 53/171 (30%), Positives = 84/171 (49%), Gaps = 5/171 (2%)
Query: 271 DTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRL 330
DT+ + L + + L P +Q + QE S S ++ + L + A LKETLRL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQE-SLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 331 YPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVP 390
YP+ R SD+ L+NY IPA + + +Y L R+P P + P+RWL+ G
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 433
Query: 391 DDPNAF-AGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKM 440
N + F G R C+G+ A M L H+++ +V +++ + KM
Sbjct: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET-LTQEDIKM 483
>Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for
aromatase P-450. ).
Length = 503
Score = 78.6 bits (185), Expect = 4e-14
Identities = 79/353 (22%), Positives = 146/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 190
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ IP+++S K D +Q +L+ +KIS L K
Sbjct: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 242
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 243 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 294
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 352
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 411
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 412 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for
aromatase (estrogen synthetase). ).
Length = 503
Score = 78.6 bits (185), Expect = 4e-14
Identities = 79/353 (22%), Positives = 146/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 190
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ IP+++S K D +Q +L+ +KIS L K
Sbjct: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 242
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 243 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 294
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 352
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 411
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 412 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 78.6 bits (185), Expect = 4e-14
Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L YPE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 297 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP---YTDAVVH 353
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P L + D++ KNY IP + + + + + P+ F P +L
Sbjct: 354 EIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ G + F FS GKR C+G+ A M + L +++ + + S+V+ K D+ +
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPK-DIDI 469
Query: 445 TPVNN 449
TP+ N
Sbjct: 470 TPIAN 474
>M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase
cytochrome P-450 gene, exon 10. ).
Length = 503
Score = 78.6 bits (185), Expect = 4e-14
Identities = 79/353 (22%), Positives = 146/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 190
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ IP+++S K D +Q +L+ +KIS L K
Sbjct: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 242
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 243 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 294
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 352
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 411
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 412 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase
mRNA, complete cds. ).
Length = 503
Score = 78.6 bits (185), Expect = 4e-14
Identities = 79/353 (22%), Positives = 146/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 190
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ IP+++S K D +Q +L+ +KIS L K
Sbjct: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 242
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 243 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 294
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 352
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 411
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 412 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase
(Aro1) mRNA, complete cds. ).
Length = 419
Score = 78.6 bits (185), Expect = 4e-14
Identities = 79/353 (22%), Positives = 146/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 49 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 106
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ IP+++S K D +Q +L+ +KIS L K
Sbjct: 107 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 158
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 159 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 210
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 211 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 268
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 269 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 327
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 328 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 376
>DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfamily
19 subfamily A polypeptide 1 protein.
Length = 503
Score = 78.6 bits (185), Expect = 4e-14
Identities = 79/353 (22%), Positives = 146/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 190
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ IP+++S K D +Q +L+ +KIS L K
Sbjct: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 242
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 243 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 294
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 352
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 411
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 412 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein
protein.
Length = 310
Score = 78.6 bits (185), Expect = 4e-14
Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L YPE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 117 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP---YTDAVVH 173
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P L + D++ KNY IP + + + + + P+ F P +L
Sbjct: 174 EIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 233
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ G + F FS GKR C+G+ A M + L +++ + + S+V+ K D+ +
Sbjct: 234 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPK-DIDI 289
Query: 445 TPVNN 449
TP+ N
Sbjct: 290 TPIAN 294
>BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein.
Length = 431
Score = 78.6 bits (185), Expect = 4e-14
Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L YPE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 238 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP---YTDAVVH 294
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P L + D++ KNY IP + + + + + P+ F P +L
Sbjct: 295 EIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 354
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ G + F FS GKR C+G+ A M + L +++ + + S+V+ K D+ +
Sbjct: 355 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPK-DIDI 410
Query: 445 TPVNN 449
TP+ N
Sbjct: 411 TPIAN 415
>BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 78.6 bits (185), Expect = 4e-14
Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L YPE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 297 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP---YTDAVVH 353
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P L + D++ KNY IP + + + + + P+ F P +L
Sbjct: 354 EIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ G + F FS GKR C+G+ A M + L +++ + + S+V+ K D+ +
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPK-DIDI 469
Query: 445 TPVNN 449
TP+ N
Sbjct: 470 TPIAN 474
>BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 78.6 bits (185), Expect = 4e-14
Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L YPE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 297 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP---YTDAVVH 353
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P L + D++ KNY IP + + + + + P+ F P +L
Sbjct: 354 EIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ G + F FS GKR C+G+ A M + L +++ + + S+V+ K D+ +
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPK-DIDI 469
Query: 445 TPVNN 449
TP+ N
Sbjct: 470 TPIAN 474
>BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 78.6 bits (185), Expect = 4e-14
Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L YPE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 297 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP---YTDAVVH 353
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P L + D++ KNY IP + + + + + P+ F P +L
Sbjct: 354 EIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ G + F FS GKR C+G+ A M + L +++ + + S+V+ K D+ +
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPK-DIDI 469
Query: 445 TPVNN 449
TP+ N
Sbjct: 470 TPIAN 474
>AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 78.6 bits (185), Expect = 4e-14
Identities = 79/353 (22%), Positives = 146/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 190
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ IP+++S K D +Q +L+ +KIS L K
Sbjct: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 242
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 243 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 294
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 352
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 411
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 412 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 18 protein.
Length = 490
Score = 78.6 bits (185), Expect = 4e-14
Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L YPE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 297 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP---YTDAVVH 353
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P L + D++ KNY IP + + + + + P+ F P +L
Sbjct: 354 EIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ G + F FS GKR C+G+ A M + L +++ + + S+V+ K D+ +
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPK-DIDI 469
Query: 445 TPVNN 449
TP+ N
Sbjct: 470 TPIAN 474
>X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein.
Length = 141
Score = 77.8 bits (183), Expect = 7e-14
Identities = 44/144 (30%), Positives = 75/144 (52%), Gaps = 4/144 (2%)
Query: 264 TIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAV 323
T + G+DT++ ++ ++ AL ++P+ Q + +E+ + GD A + +H + Y
Sbjct: 1 TFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMC 59
Query: 324 LKETLRLYPIVPIALRQTESDIELKN-YTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
+KE LRLYP VP R+ + + + ++P +L IYGL+ +P P+ F P R
Sbjct: 60 IKEALRLYPPVPGISRELSTPVTFPDGRSLPKGITVMLSIYGLHHNPKVWPNPEVFDPSR 119
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTC 406
+ PG +AF FS G R C
Sbjct: 120 F-APGSA-QHSHAFLPFSGGSRNC 141
>X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase
(P-450aldo) protein.
Length = 503
Score = 77.8 bits (183), Expect = 7e-14
Identities = 51/170 (30%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 271 DTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRL 330
DT+++ L + + L P++Q + QE S S ++ + L + A LKETLRL
Sbjct: 317 DTTAFPLLMTLFELARNPDVQQILRQE-SLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 331 YPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVP 390
YP+ R SD+ L+NY IPA + + +Y L R+ P + P+RWL+ G
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435
Query: 391 DDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKM 440
+ + F G R C+G+ A M L H+++ + V +++ + KM
Sbjct: 436 RNFH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVET-LTQEDIKM 483
>L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18
protein.
Length = 490
Score = 77.8 bits (183), Expect = 7e-14
Identities = 53/185 (28%), Positives = 92/185 (49%), Gaps = 10/185 (5%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVYVEAVLK 325
AG +T+S L ++ L YPE+ KV +E+ + G + + D+SH P Y +AV+
Sbjct: 297 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP---YTDAVVH 353
Query: 326 ETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
E R ++P L + D++ KNY IP + + + + P+ F P +L
Sbjct: 354 EIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGMTIITSLTSVLHNDKEFPNPEMFDPGHFL 413
Query: 385 EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLM 444
+ G + F FS GKR C+G+ A M + L +++ + + S+V+ K D+ +
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPK-DIDI 469
Query: 445 TPVNN 449
TP+ N
Sbjct: 470 TPIAN 474
>D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase
protein.
Length = 503
Score = 77.8 bits (183), Expect = 7e-14
Identities = 51/170 (30%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 271 DTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVLKETLRL 330
DT+++ L + + L P++Q + QE S S ++ + L + A LKETLRL
Sbjct: 317 DTTAFPLLMTLFELARNPDVQQILRQE-SLAAAASISEHPQKATTELPLLRAALKETLRL 375
Query: 331 YPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVP 390
YP+ R SD+ L+NY IPA + + +Y L R+ P + P+RWL+ G
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435
Query: 391 DDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKM 440
+ + F G R C+G+ A M L H+++ + V +++ + KM
Sbjct: 436 RNFH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVET-LTQEDIKM 483
>X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein.
Length = 521
Score = 77.4 bits (182), Expect = 1e-13
Identities = 52/192 (27%), Positives = 96/192 (50%), Gaps = 5/192 (2%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+I+ V ++ G DT+S L + + ++Q+ + EV + ++ D+ +
Sbjct: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDM-ATMLQL 373
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ ++A +KETLRL+PI R +D+ L++Y IPA + + IY L R P + D
Sbjct: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433
Query: 377 TFRPERWL-EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD-IS 434
F P RWL + + N GF G R C+G+ A + M L++++ ++V +S
Sbjct: 434 NFDPTRWLSKDKNITYFRN--LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLS 491
Query: 435 KVEFKMDVLMTP 446
V ++++ P
Sbjct: 492 DVGTTFNLILMP 503
>M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc
protein.
Length = 239
Score = 77.4 bits (182), Expect = 1e-13
Identities = 52/192 (27%), Positives = 96/192 (50%), Gaps = 5/192 (2%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+I+ V ++ G DT+S L + + ++Q+ + EV + ++ D+ +
Sbjct: 33 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDM-ATMLQL 91
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ ++A +KETLRL+PI R +D+ L++Y IPA + + IY L R P + D
Sbjct: 92 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 151
Query: 377 TFRPERWL-EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD-IS 434
F P RWL + + N GF G R C+G+ A + M L++++ ++V +S
Sbjct: 152 NFDPTRWLSKDKNITYFRN--LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLS 209
Query: 435 KVEFKMDVLMTP 446
V ++++ P
Sbjct: 210 DVGTTFNLILMP 221
>M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein.
Length = 521
Score = 77.4 bits (182), Expect = 1e-13
Identities = 52/192 (27%), Positives = 96/192 (50%), Gaps = 5/192 (2%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+I+ V ++ G DT+S L + + ++Q+ + EV + ++ D+ +
Sbjct: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDM-ATMLQL 373
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ ++A +KETLRL+PI R +D+ L++Y IPA + + IY L R P + D
Sbjct: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433
Query: 377 TFRPERWL-EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD-IS 434
F P RWL + + N GF G R C+G+ A + M L++++ ++V +S
Sbjct: 434 NFDPTRWLSKDKNITYFRN--LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLS 491
Query: 435 KVEFKMDVLMTP 446
V ++++ P
Sbjct: 492 DVGTTFNLILMP 503
>BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 77.4 bits (182), Expect = 1e-13
Identities = 59/252 (23%), Positives = 111/252 (44%), Gaps = 15/252 (5%)
Query: 178 FQNVLLHNSFIYKISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRY 237
+Q +L+ +KIS L KK E+ V+ + ++I KR + +E C D
Sbjct: 224 WQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE-CMD----- 277
Query: 238 KSIXXXXXXXXXXXXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQE 297
+ + +++A DT S L ++ + +P ++ + +E
Sbjct: 278 --FATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKE 335
Query: 298 VSSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSN 357
+ ++ G+ + +D L +E + E++R P+V + +R+ D + Y + +N
Sbjct: 336 IQTVIGERDIKIDDIQK--LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTN 393
Query: 358 CVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMK 417
+L I ++R + P + F E + + VP F F G R C GK A++ MK
Sbjct: 394 IILNIGRMHRLEFF-PKPNEFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMK 448
Query: 418 TTLVHLIRRYKV 429
LV L+RR+ V
Sbjct: 449 AILVTLLRRFHV 460
>BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family
11, subfamily A, polypeptide 1 protein.
Length = 521
Score = 77.4 bits (182), Expect = 1e-13
Identities = 52/192 (27%), Positives = 96/192 (50%), Gaps = 5/192 (2%)
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+I+ V ++ G DT+S L + + ++Q+ + EV + ++ D+ +
Sbjct: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDM-ATMLQL 373
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
+ ++A +KETLRL+PI R +D+ L++Y IPA + + IY L R P + D
Sbjct: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433
Query: 377 TFRPERWL-EPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTAD-IS 434
F P RWL + + N GF G R C+G+ A + M L++++ ++V +S
Sbjct: 434 NFDPTRWLSKDKNITYFRN--LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLS 491
Query: 435 KVEFKMDVLMTP 446
V ++++ P
Sbjct: 492 DVGTTFNLILMP 503
>M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatase
protein.
Length = 419
Score = 77.0 bits (181), Expect = 1e-13
Identities = 79/353 (22%), Positives = 146/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 49 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 106
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ IP+++S K D +Q +L+ +KIS L K
Sbjct: 107 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 158
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 159 KYEKSVKDLKDAIEVLIAEKRCRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 210
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 211 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 268
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 269 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 327
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 328 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 376
>M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 77.0 bits (181), Expect = 1e-13
Identities = 76/362 (20%), Positives = 154/362 (42%), Gaps = 21/362 (5%)
Query: 77 GDGLITSSGETWKRHRK-----LLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPV 131
G G++ S+G+ WK R+ L N ++ + + +E+R LV E+ A P
Sbjct: 104 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKAS-PC 159
Query: 132 EVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSML-IYRFQNVLLHNSFIYK 190
+ T ++ F + D Q++++ ++KL + I + + N+F
Sbjct: 160 DPTFILGCAPCNVICSIIFHKRFDYKD--QQFLNLMEKLNENIKILSSPWIQICNNFSPI 217
Query: 191 ISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
I ++++ V M + I+++ +E ++ + + K
Sbjct: 218 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM---EKEKHNQP 274
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV- 309
+ + + AG +T+S L ++ L +PE+ KV +E+ + G + +
Sbjct: 275 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 334
Query: 310 -DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNR 367
D+SH P Y +AV+ E R ++P +L + DI+ +NY IP + ++ + +
Sbjct: 335 QDRSHMP---YTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 391
Query: 368 HPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P+ F P +L+ G F FS GKR C+G+ A M + L +++ +
Sbjct: 392 DNKEFPNPEMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 451
Query: 428 KV 429
+
Sbjct: 452 NL 453
>M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 77.0 bits (181), Expect = 1e-13
Identities = 76/362 (20%), Positives = 154/362 (42%), Gaps = 21/362 (5%)
Query: 77 GDGLITSSGETWKRHRK-----LLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPV 131
G G++ S+G+ WK R+ L N ++ + + +E+R LV E+ A P
Sbjct: 104 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKAS-PC 159
Query: 132 EVTTPFRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSML-IYRFQNVLLHNSFIYK 190
+ T ++ F + D Q++++ ++KL + I + + N+F
Sbjct: 160 DPTFILGCAPCNVICSIIFHKRFDYKD--QQFLNLMEKLNENIKILSSPWIQICNNFSPI 217
Query: 191 ISGLKKKEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXX 250
I ++++ V M + I+++ +E ++ + + K
Sbjct: 218 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM---EKEKHNQP 274
Query: 251 XXXXXXEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV- 309
+ + + AG +T+S L ++ L +PE+ KV +E+ + G + +
Sbjct: 275 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 334
Query: 310 -DKSHYPGLVYVEAVLKETLRLYPIVPIALRQTES-DIELKNYTIPADSNCVLGIYGLNR 367
D+SH P Y +AV+ E R ++P +L + DI+ +NY IP + ++ + +
Sbjct: 335 QDRSHMP---YTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 391
Query: 368 HPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
P+ F P +L+ G F FS GKR C+G+ A M + L +++ +
Sbjct: 392 DNKEFPNPEMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 451
Query: 428 KV 429
+
Sbjct: 452 NL 453
>J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein.
Length = 503
Score = 77.0 bits (181), Expect = 1e-13
Identities = 79/353 (22%), Positives = 146/353 (41%), Gaps = 28/353 (7%)
Query: 80 LITSSGETWKRHRKLLNPAFNQQILNSFIGVFNDESRK---LVSEIGNEMAKGPVEVTTP 136
+ ++ E WK R A + L + V + + + E+ NE G V+V T
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE--SGYVDVLTL 190
Query: 137 FRQMAFRLLFLTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKK 196
R++ IP+++S K D +Q +L+ +KIS L K
Sbjct: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYK 242
Query: 197 KEEQIVETVHAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXX 256
K E+ V+ + ++I KR + +E C D
Sbjct: 243 KYEKSVKDLKDAIEVLIAEKRCRISTEEKLEE-CMD-------FATELILAEKRGDLTRE 294
Query: 257 EIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPG 316
+ + +++A DT S L ++ + +P ++ + +E+ ++ G+ + +D
Sbjct: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-- 352
Query: 317 LVYVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAH 376
L +E + E++R P+V + +R+ D + Y + +N +L I ++R + P +
Sbjct: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPN 411
Query: 377 TFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV 429
F E + + VP F F G R C GK A++ MK LV L+RR+ V
Sbjct: 412 EFTLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 77.0 bits (181), Expect = 1e-13
Identities = 54/169 (31%), Positives = 82/169 (48%), Gaps = 5/169 (2%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVE 321
V+ I AG+DT + ++ +M L + PEIQ K+ +E+ ++ G E S P L Y+E
Sbjct: 311 VNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RERRPRLSDRPQLPYLE 369
Query: 322 AVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRP 380
A + ET R P +P + T D L + IP + + +N P D FRP
Sbjct: 370 AFILETFRHSPFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRP 429
Query: 381 ERWLEPGGVP-DDP--NAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRR 426
ER+L G + P F +GKR CIG+V A + L L+++
Sbjct: 430 ERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478
>AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 428
Score = 76.6 bits (180), Expect = 2e-13
Identities = 57/196 (29%), Positives = 89/196 (45%), Gaps = 8/196 (4%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSS--MFGDSEAD--VDKSHYPGLVYV 320
++ G++T++ T ++ LG YP + KV +E+ S + S D +D L Y+
Sbjct: 228 LLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYI 287
Query: 321 EAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRP 380
V+KETLRL P VP R EL Y IP N + I + + F P
Sbjct: 288 GCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNP 347
Query: 381 ERWLEPGGVPDDPN--AFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEF 438
+R++ P P+D + +F F G R+C+GK +A + +K V L R
Sbjct: 348 DRFMLPH--PEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTM 405
Query: 439 KMDVLMTPVNNCNVKF 454
K + PV+N +F
Sbjct: 406 KTSPTVYPVDNLPARF 421
>AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 57/196 (29%), Positives = 89/196 (45%), Gaps = 8/196 (4%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSS--MFGDSEAD--VDKSHYPGLVYV 320
++ G++T++ T ++ LG YP + KV +E+ S + S D +D L Y+
Sbjct: 297 LLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYI 356
Query: 321 EAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRP 380
V+KETLRL P VP R EL Y IP N + I + + F P
Sbjct: 357 GCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNP 416
Query: 381 ERWLEPGGVPDDPN--AFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEF 438
+R++ P P+D + +F F G R+C+GK +A + +K V L R
Sbjct: 417 DRFMLPH--PEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTM 474
Query: 439 KMDVLMTPVNNCNVKF 454
K + PV+N +F
Sbjct: 475 KTSPTVYPVDNLPARF 490
>AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxylase
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 57/196 (29%), Positives = 89/196 (45%), Gaps = 8/196 (4%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSS--MFGDSEAD--VDKSHYPGLVYV 320
++ G++T++ T ++ LG YP + KV +E+ S + S D +D L Y+
Sbjct: 297 LLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYI 356
Query: 321 EAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRP 380
V+KETLRL P VP R EL Y IP N + I + + F P
Sbjct: 357 GCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNP 416
Query: 381 ERWLEPGGVPDDPN--AFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEF 438
+R++ P P+D + +F F G R+C+GK +A + +K V L R
Sbjct: 417 DRFMLPH--PEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTM 474
Query: 439 KMDVLMTPVNNCNVKF 454
K + PV+N +F
Sbjct: 475 KTSPTVYPVDNLPARF 490
>X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase
protein.
Length = 495
Score = 76.2 bits (179), Expect = 2e-13
Identities = 74/345 (21%), Positives = 145/345 (42%), Gaps = 16/345 (4%)
Query: 88 WKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPVEVTTPFRQMAFRLLFL 147
WK H+KL A I +S V +++ + + PV + F + ++
Sbjct: 117 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICY 175
Query: 148 TAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFI--YKISGLKKKEEQIVETV 205
FG ++D + Y + ++L + ++ F+ + GL++ ++ I +
Sbjct: 176 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 235
Query: 206 HAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTI 265
H + M +++ +E+ D Y + + VD +
Sbjct: 236 HIVE-MQLRQHKESLVAGQWRDMMDY----MLQGVAQPSMEEGSGQLLEGHVHMAAVD-L 289
Query: 266 IVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD--SEADVDKSHYPGLVYVEAV 323
++ G +T++ L+ ++ L +PEIQ ++ +E+ G S + V + L + A
Sbjct: 290 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDHARLPLLNAT 349
Query: 324 LKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
+ E LRL P+VP+AL +T + Y IP + + + G + H F P+R
Sbjct: 350 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 409
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+LEPG + A A F G R C+G+ A + + L L++ +
Sbjct: 410 FLEPG---KNSRALA-FGCGARVCLGEPLARLELFVVLTRLLQAF 450
>DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.2 bits (179), Expect = 2e-13
Identities = 50/170 (29%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ M G D++H P Y
Sbjct: 299 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDMIGQVRRPEMGDQAHMP---Y 355
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 356 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 414
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 415 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein.
Length = 497
Score = 75.8 bits (178), Expect = 3e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein.
Length = 497
Score = 75.8 bits (178), Expect = 3e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein.
Length = 280
Score = 75.8 bits (178), Expect = 3e-13
Identities = 39/118 (33%), Positives = 65/118 (55%), Gaps = 1/118 (0%)
Query: 265 IIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADVDKSHYPGLVYVEAVL 324
II A YDT+S L +M L ++P++Q K+ +E+ ++ ++A V + Y++ V+
Sbjct: 162 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVV 220
Query: 325 KETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
ETLRL+P+V R + DIE+ IP ++ IY L+ P + + F PER
Sbjct: 221 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 278
>M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoquine
4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
cds. ).
Length = 500
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 298 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 357
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 358 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 413
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 414 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 467
>M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein.
Length = 373
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 171 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 230
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 231 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 286
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 287 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 340
>DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6
protein.
Length = 496
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 294 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 353
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 354 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 409
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 410 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 463
>DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6
protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 295 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 354
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 355 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 410
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 411 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein
protein.
Length = 173
Score = 75.4 bits (177), Expect = 4e-13
Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 4/142 (2%)
Query: 319 YVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTF 378
Y++ V+ ETLRL+P+ R + D+E+ IP S V+ Y L+ P + + F
Sbjct: 26 YLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF 85
Query: 379 RPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV-TADISKVE 437
RPER+ + DP + F G R CIG +ALM+MK L+ +++ + +++
Sbjct: 86 RPERFSKKKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 144
Query: 438 FKMDV--LMTPVNNCNVKFELR 457
K+D L+ P +K + R
Sbjct: 145 LKLDTQGLLQPEKPIVLKVDSR 166
>AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein.
Length = 160
Score = 75.4 bits (177), Expect = 4e-13
Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 4/142 (2%)
Query: 319 YVEAVLKETLRLYPIVPIALRQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTF 378
Y++ V+ ETLRL+P+ R + D+E+ IP S V+ Y L+ P + + F
Sbjct: 13 YLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF 72
Query: 379 RPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKV-TADISKVE 437
RPER+ + DP + F G R CIG +ALM+MK L+ +++ + +++
Sbjct: 73 RPERFSKKKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 131
Query: 438 FKMDV--LMTPVNNCNVKFELR 457
K+D L+ P +K + R
Sbjct: 132 LKLDTQGLLQPEKPIVLKVDSR 153
>AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxylase
mutant allele variant protein.
Length = 566
Score = 75.4 bits (177), Expect = 4e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 258 IRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYP 315
+R V + AG T+S L ++ + +P++Q +V QE+ + G D++H P
Sbjct: 364 LRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP 423
Query: 316 GLVYVEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGP 373
Y AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 424 ---YTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-E 479
Query: 374 DAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 480 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 533
>X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein.
Length = 512
Score = 74.9 bits (176), Expect = 5e-13
Identities = 56/191 (29%), Positives = 89/191 (46%), Gaps = 13/191 (6%)
Query: 268 AGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEAD--VDKSHYPGLVYVEAVLK 325
AG+DT + ++ +M L P +Q K+ +E+ ++ G S D+SH P Y+EA +
Sbjct: 317 AGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLP---YMEAFIL 373
Query: 326 ETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWL 384
ET R +VP + T D LK + IP + + +N + F PER+L
Sbjct: 374 ETFRHSSLVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433
Query: 385 EPGGVPDD--PNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDV 442
P G D F +GKR CIG+ A + L L++R + + + K+D
Sbjct: 434 TPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQRVEFSVPLG---VKVD- 489
Query: 443 LMTPVNNCNVK 453
MTP+ +K
Sbjct: 490 -MTPIYGLTMK 499
>AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 74.9 bits (176), Expect = 5e-13
Identities = 74/345 (21%), Positives = 144/345 (41%), Gaps = 16/345 (4%)
Query: 88 WKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPVEVTTPFRQMAFRLLFL 147
WK H+KL A I +S V +++ + + PV + F + ++
Sbjct: 116 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICY 174
Query: 148 TAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFI--YKISGLKKKEEQIVETV 205
FG ++D + Y + ++L + ++ F+ + GL++ ++ I +
Sbjct: 175 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 234
Query: 206 HAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTI 265
H + M +++ +E+ D Y + + VD +
Sbjct: 235 HIVE-MQLRQHKESLVAGQWRDMMDY----MLQGVAQPSMEEGSGQLLEGHVHMAAVD-L 288
Query: 266 IVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD--SEADVDKSHYPGLVYVEAV 323
++ G +T++ L+ ++ L +PEIQ ++ +E+ G S + V L + A
Sbjct: 289 LIGGTETTANTLSWAVVFLFHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 348
Query: 324 LKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
+ E LRL P+VP+AL +T + Y IP + + + G + H F P+R
Sbjct: 349 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 408
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+LEPG + A A F G R C+G+ A + + L L++ +
Sbjct: 409 FLEPG---KNSRALA-FGCGARVCLGEPLARLELFVVLTRLLQAF 449
>AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,
CYP21 protein.
Length = 494
Score = 74.9 bits (176), Expect = 5e-13
Identities = 74/345 (21%), Positives = 144/345 (41%), Gaps = 16/345 (4%)
Query: 88 WKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPVEVTTPFRQMAFRLLFL 147
WK H+KL A I +S V +++ + + PV + F + ++
Sbjct: 116 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGT-PVAIEEEFSPLTCSIICY 174
Query: 148 TAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFI--YKISGLKKKEEQIVETV 205
FG ++D + Y + ++L + ++ F+ + GL++ ++ I +
Sbjct: 175 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 234
Query: 206 HAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTI 265
H + M +++ +E+ D Y + + VD +
Sbjct: 235 HIVE-MQLRQHKESLVAGQWRDMMDY----MLQGVAQPSMEEGSGQLLEGHVHMAAVD-L 288
Query: 266 IVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD--SEADVDKSHYPGLVYVEAV 323
++ G +T++ L+ ++ L +PEIQ ++ +E+ G S + V L + A
Sbjct: 289 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 348
Query: 324 LKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
+ E LRL P+VP+AL +T + Y IP + + + G + H F P+R
Sbjct: 349 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 408
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+LEPG + A A F G R C+G+ A + + L L++ +
Sbjct: 409 FLEPG---KNSRALA-FGCGARVCLGEPLARLELFVVLTRLLQAF 449
>M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 74.5 bits (175), Expect = 7e-13
Identities = 74/345 (21%), Positives = 144/345 (41%), Gaps = 16/345 (4%)
Query: 88 WKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPVEVTTPFRQMAFRLLFL 147
WK H+KL A I +S V +++ + + PV + F + ++
Sbjct: 117 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICY 175
Query: 148 TAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFI--YKISGLKKKEEQIVETV 205
FG ++D + Y + ++L + ++ F+ + GL++ ++ I +
Sbjct: 176 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 235
Query: 206 HAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTI 265
H + M +++ +E+ D Y + + VD +
Sbjct: 236 HIVE-MQLRQHKESLVAGQWRDMMDY----MLQGVAQPTMEEGSGQLLEGHVHMAAVD-L 289
Query: 266 IVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD--SEADVDKSHYPGLVYVEAV 323
++ G +T++ L+ ++ L +PEIQ ++ +E+ G S + V L + A
Sbjct: 290 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 349
Query: 324 LKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
+ E LRL P+VP+AL +T + Y IP + + + G + H F P+R
Sbjct: 350 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 409
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+LEPG + A A F G R C+G+ A + + L L++ +
Sbjct: 410 FLEPG---KNSRALA-FGCGARVCLGEPLARLELFVVLTRLLQAF 450
>M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human
21-hydroxylase B gene, complete cds. ).
Length = 495
Score = 74.5 bits (175), Expect = 7e-13
Identities = 74/345 (21%), Positives = 144/345 (41%), Gaps = 16/345 (4%)
Query: 88 WKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPVEVTTPFRQMAFRLLFL 147
WK H+KL A I +S V +++ + + PV + F + ++
Sbjct: 117 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICY 175
Query: 148 TAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFI--YKISGLKKKEEQIVETV 205
FG ++D + Y + ++L + ++ F+ + GL++ ++ I +
Sbjct: 176 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 235
Query: 206 HAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTI 265
H + M +++ +E+ D Y + + VD +
Sbjct: 236 HIVE-MQLRQHKESLVAGQWRDMMDY----MLQGVAQPSMEEGSGQLLEGHVHMAAVD-L 289
Query: 266 IVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD--SEADVDKSHYPGLVYVEAV 323
++ G +T++ L+ ++ L +PEIQ ++ +E+ G S + V L + A
Sbjct: 290 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 349
Query: 324 LKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
+ E LRL P+VP+AL +T + Y IP + + + G + H F P+R
Sbjct: 350 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 409
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+LEPG + A A F G R C+G+ A + + L L++ +
Sbjct: 410 FLEPG---KNSRALA-FGCGARVCLGEPLARLELFVVLTRLLQAF 450
>M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein.
Length = 494
Score = 74.5 bits (175), Expect = 7e-13
Identities = 74/345 (21%), Positives = 144/345 (41%), Gaps = 16/345 (4%)
Query: 88 WKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPVEVTTPFRQMAFRLLFL 147
WK H+KL A I +S V +++ + + PV + F + ++
Sbjct: 116 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICY 174
Query: 148 TAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFI--YKISGLKKKEEQIVETV 205
FG ++D + Y + ++L + ++ F+ + GL++ ++ I +
Sbjct: 175 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 234
Query: 206 HAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTI 265
H + M +++ +E+ D Y + + VD +
Sbjct: 235 HIVE-MQLRQHKESLVAGQWRDMMDY----MLQGVAQPSMEEGSGQLLEGHVHMAAVD-L 288
Query: 266 IVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD--SEADVDKSHYPGLVYVEAV 323
++ G +T++ L+ ++ L +PEIQ ++ +E+ G S + V L + A
Sbjct: 289 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 348
Query: 324 LKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
+ E LRL P+VP+AL +T + Y IP + + + G + H F P+R
Sbjct: 349 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 408
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+LEPG + A A F G R C+G+ A + + L L++ +
Sbjct: 409 FLEPG---KNSRALA-FGCGARVCLGEPLARLELFVVLTRLLQAF 449
>DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6
protein.
Length = 500
Score = 74.5 bits (175), Expect = 7e-13
Identities = 49/170 (28%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ + G D++H P Y
Sbjct: 302 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP---Y 358
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 359 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 417
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 418 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 467
>DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 74.5 bits (175), Expect = 7e-13
Identities = 49/170 (28%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ + G D++H P Y
Sbjct: 299 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP---Y 355
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 356 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 414
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 415 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 74.5 bits (175), Expect = 7e-13
Identities = 49/170 (28%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ + G D++H P Y
Sbjct: 299 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP---Y 355
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 356 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 414
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 415 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 74.5 bits (175), Expect = 7e-13
Identities = 49/170 (28%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ + G D++H P Y
Sbjct: 299 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP---Y 355
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 356 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 414
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 415 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 74.5 bits (175), Expect = 7e-13
Identities = 49/170 (28%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ + G D++H P Y
Sbjct: 299 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP---Y 355
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 356 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 414
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 415 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 74.5 bits (175), Expect = 7e-13
Identities = 49/170 (28%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ + G D++H P Y
Sbjct: 299 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP---Y 355
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 356 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 414
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 415 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 74.5 bits (175), Expect = 7e-13
Identities = 49/170 (28%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ + G D++H P Y
Sbjct: 299 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP---Y 355
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 356 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 414
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 415 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 74.5 bits (175), Expect = 7e-13
Identities = 49/170 (28%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ + G D++H P Y
Sbjct: 299 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP---Y 355
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 356 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 414
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 415 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 464
>CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein.
Length = 446
Score = 74.5 bits (175), Expect = 7e-13
Identities = 49/170 (28%), Positives = 80/170 (47%), Gaps = 8/170 (4%)
Query: 262 VDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGDSEADV--DKSHYPGLVY 319
V + AG T+S L ++ + +P++Q +V QE+ + G D++H P Y
Sbjct: 248 VADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMP---Y 304
Query: 320 VEAVLKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYG-LNRHPVWGPDAHT 377
AV+ E R IVP+ + T DIE++ + IP + + + L VW
Sbjct: 305 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR 363
Query: 378 FRPERWLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
F PE +L+ G P AF FS G+R C+G+ A M + L++ +
Sbjct: 364 FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 413
>BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 464
Score = 74.5 bits (175), Expect = 7e-13
Identities = 74/345 (21%), Positives = 144/345 (41%), Gaps = 16/345 (4%)
Query: 88 WKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPVEVTTPFRQMAFRLLFL 147
WK H+KL A I +S V +++ + + PV + F + ++
Sbjct: 86 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICY 144
Query: 148 TAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFI--YKISGLKKKEEQIVETV 205
FG ++D + Y + ++L + ++ F+ + GL++ ++ I +
Sbjct: 145 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 204
Query: 206 HAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTI 265
H + M +++ +E+ D Y + + VD +
Sbjct: 205 HIVE-MQLRQHKESLVAGQWRDMMDY----MLQGVAQPSMEEGSGQLLEGHVHMAAVD-L 258
Query: 266 IVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD--SEADVDKSHYPGLVYVEAV 323
++ G +T++ L+ ++ L +PEIQ ++ +E+ G S + V L + A
Sbjct: 259 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 318
Query: 324 LKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
+ E LRL P+VP+AL +T + Y IP + + + G + H F P+R
Sbjct: 319 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 378
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+LEPG + A A F G R C+G+ A + + L L++ +
Sbjct: 379 FLEPG---KNSRALA-FGCGARVCLGEPLARLELFVVLTRLLQAF 419
>BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family
21, subfamily A, polypeptide 2 protein.
Length = 494
Score = 74.5 bits (175), Expect = 7e-13
Identities = 74/345 (21%), Positives = 144/345 (41%), Gaps = 16/345 (4%)
Query: 88 WKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPVEVTTPFRQMAFRLLFL 147
WK H+KL A I +S V +++ + + PV + F + ++
Sbjct: 116 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICY 174
Query: 148 TAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFI--YKISGLKKKEEQIVETV 205
FG ++D + Y + ++L + ++ F+ + GL++ ++ I +
Sbjct: 175 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 234
Query: 206 HAMSNMIIKRKREASKNKSPTDEHCYDTTHRYKSIXXXXXXXXXXXXXXXXEIRDEVDTI 265
H + M +++ +E+ D Y + + VD +
Sbjct: 235 HIVE-MQLRQHKESLVAGQWRDMMDY----MLQGVAQPSMEEGSGQLLEGHVHMAAVD-L 288
Query: 266 IVAGYDTSSWVLTLVMMALGSYPEIQNKVYQEVSSMFGD--SEADVDKSHYPGLVYVEAV 323
++ G +T++ L+ ++ L +PEIQ ++ +E+ G S + V L + A
Sbjct: 289 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 348
Query: 324 LKETLRLYPIVPIAL-RQTESDIELKNYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPER 382
+ E LRL P+VP+AL +T + Y IP + + + G + H F P+R
Sbjct: 349 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 408
Query: 383 WLEPGGVPDDPNAFAGFSVGKRTCIGKVYALMSMKTTLVHLIRRY 427
+LEPG + A A F G R C+G+ A + + L L++ +
Sbjct: 409 FLEPG---KNSRALA-FGCGARVCLGEPLARLELFVVLTRLLQAF 449
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.137 0.404
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 63,718,558
Number of Sequences: 224733
Number of extensions: 2670698
Number of successful extensions: 5479
Number of sequences better than 10.0: 437
Number of HSP's better than 10.0 without gapping: 359
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 4362
Number of HSP's gapped (non-prelim): 543
length of query: 458
length of database: 73,234,838
effective HSP length: 92
effective length of query: 366
effective length of database: 52,559,402
effective search space: 19236741132
effective search space used: 19236741132
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 67 (31.1 bits)
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