Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002272-TA|BGIBMGA002272-PA|IPR002401|E-class P450, group
I, IPR001128|Cytochrome P450, IPR002048|Calcium-binding EF-hand
(510 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family... 153 1e-36
AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2 pro... 153 1e-36
AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens ... 153 1e-36
AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens ... 153 1e-36
U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein. 144 9e-34
BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family... 143 2e-33
AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4 omega-hy... 143 2e-33
D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4 omega-hydr... 142 3e-33
BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family... 142 3e-33
BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family... 142 3e-33
AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfam... 142 3e-33
AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein. 142 3e-33
AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family... 137 1e-31
AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein. 137 1e-31
D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV prot... 136 2e-31
AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4 omega-hy... 136 2e-31
AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4 omega-hy... 136 2e-31
BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family... 133 1e-30
AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein. 133 1e-30
AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein. 133 1e-30
AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family... 133 1e-30
AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens ... 133 1e-30
AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens ... 133 1e-30
AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens ... 133 1e-30
BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family... 132 4e-30
AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein. 132 4e-30
AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform... 132 4e-30
AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein. 132 4e-30
AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein. 132 4e-30
AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein. 132 4e-30
AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein. 130 9e-30
BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family... 128 5e-29
BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family... 128 5e-29
BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family... 128 5e-29
AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens ... 128 6e-29
BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein. 121 5e-27
AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein. 121 5e-27
AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein. 118 5e-26
X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for ... 118 6e-26
J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung cyto... 118 6e-26
DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family... 118 6e-26
BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family... 118 6e-26
AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P4... 118 6e-26
AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P4... 118 6e-26
AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein. 118 6e-26
AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family... 118 6e-26
AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family... 118 6e-26
AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family... 118 6e-26
AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family... 118 6e-26
AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family... 118 6e-26
AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family... 118 6e-26
AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein. 118 6e-26
S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxyl... 109 2e-23
S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxyl... 109 3e-23
L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein. 108 4e-23
D26481-1|BAA05491.1| 519|Homo sapiens fatty acids omega-hydroxy... 108 4e-23
AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family... 108 4e-23
AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22 pr... 108 4e-23
AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family... 108 4e-23
AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K p... 107 9e-23
AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfam... 107 1e-22
AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, famil... 105 3e-22
AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid omega-hydrox... 105 3e-22
AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein. 104 9e-22
AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein. 104 9e-22
AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family... 104 9e-22
AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family... 104 9e-22
AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43... 101 8e-21
D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxyl... 100 1e-20
BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein. 100 1e-20
AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43... 100 1e-20
AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfami... 100 1e-20
AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43... 100 1e-20
AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfami... 100 1e-20
AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein. 100 1e-20
L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3 ... 98 7e-20
AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfami... 98 7e-20
AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein. 98 7e-20
M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrom... 96 3e-19
J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipin... 96 3e-19
X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for ... 95 4e-19
M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA... 95 4e-19
M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver glu... 95 4e-19
D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein. 95 4e-19
DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family ... 95 4e-19
DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family... 95 4e-19
BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfam... 95 4e-19
BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family... 95 4e-19
AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein. 95 4e-19
AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein. 95 4e-19
AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein. 95 4e-19
AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450 polypep... 95 4e-19
AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4 p... 95 4e-19
BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family... 95 7e-19
AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxyl... 95 7e-19
S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D 24-hy... 94 1e-18
AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylas... 94 1e-18
AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family... 94 1e-18
AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family... 94 1e-18
X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase... 93 2e-18
M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase pro... 93 2e-18
J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3 prot... 93 2e-18
BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family... 93 2e-18
BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family... 93 2e-18
BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family... 93 2e-18
AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein. 93 2e-18
AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase pro... 92 4e-18
AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family... 92 4e-18
D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa pro... 92 5e-18
BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family... 92 5e-18
AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant... 92 5e-18
AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450 polypep... 92 5e-18
AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4 pro... 92 5e-18
D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV prot... 90 1e-17
BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein. 90 1e-17
AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family... 90 1e-17
BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein. 88 6e-17
AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein. 88 6e-17
AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, famil... 87 1e-16
AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens ... 86 3e-16
BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein. 85 6e-16
AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfami... 85 6e-16
Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for ... 84 1e-15
X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for ... 84 1e-15
M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase... 84 1e-15
M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatas... 84 1e-15
M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase... 84 1e-15
M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase... 84 1e-15
J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein. 84 1e-15
DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfami... 84 1e-15
BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family... 84 1e-15
BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family... 84 1e-15
AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family... 84 1e-15
AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13 va... 82 4e-15
AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13 va... 82 4e-15
AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13 va... 82 4e-15
AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13 va... 82 4e-15
AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13 pr... 82 4e-15
AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family... 82 5e-15
AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin D-1-... 82 5e-15
AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 82 5e-15
AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin ... 82 5e-15
AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 82 5e-15
AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 82 5e-15
AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 82 5e-15
AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 82 5e-15
AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 82 5e-15
M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein. 81 9e-15
BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family... 81 9e-15
BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family... 81 9e-15
BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family... 81 9e-15
AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13 va... 81 9e-15
AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1 pro... 81 9e-15
M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid 1... 80 2e-14
DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6 pro... 80 2e-14
X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein. 80 2e-14
M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein. 80 2e-14
BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family... 80 2e-14
AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein. 80 2e-14
M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein. 79 3e-14
M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6 prot... 79 3e-14
M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoqu... 79 3e-14
M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein. 79 3e-14
M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein. 79 3e-14
M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein. 79 3e-14
M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein. 79 3e-14
DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family... 79 3e-14
DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6 pro... 79 3e-14
BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family... 79 3e-14
BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family... 79 3e-14
BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family... 79 3e-14
BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family... 79 3e-14
BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family... 79 3e-14
AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6 prot... 79 3e-14
AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family... 79 3e-14
AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxyl... 79 3e-14
X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase (P-... 79 5e-14
X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mR... 79 5e-14
X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is ... 79 5e-14
M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein. 79 5e-14
D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase pr... 79 5e-14
BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family... 79 5e-14
BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family... 79 5e-14
BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family... 79 5e-14
BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family... 79 5e-14
AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6 pro... 79 5e-14
X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for ... 78 6e-14
AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family... 78 6e-14
AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family... 78 6e-14
AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxyla... 78 6e-14
X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein. 77 1e-13
M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc prot... 77 1e-13
M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein. 77 1e-13
BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family... 77 1e-13
U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450 monooxyge... 77 2e-13
U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein. 77 2e-13
BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family... 77 2e-13
BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family... 77 2e-13
AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family... 77 2e-13
AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein. 77 2e-13
X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for ... 76 3e-13
DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6 pro... 76 3e-13
DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6 pro... 76 3e-13
DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6 pro... 76 3e-13
DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6 pro... 76 3e-13
DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6 pro... 76 3e-13
DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6 pro... 76 3e-13
DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6 pro... 76 3e-13
DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6 pro... 76 3e-13
CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein. 76 3e-13
BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family... 76 3e-13
BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family... 76 3e-13
BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family... 76 3e-13
BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein. 76 3e-13
AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2 pro... 76 3e-13
BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family... 76 3e-13
U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein. 75 6e-13
DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6 pro... 75 6e-13
AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome P-45... 75 6e-13
X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein. 75 8e-13
M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein. 75 8e-13
BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family... 75 8e-13
BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family... 75 8e-13
BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein. 75 8e-13
X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein. 74 1e-12
X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein. 74 1e-12
M12079-1|AAA52152.1| 191|Homo sapiens POR protein. 74 1e-12
K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein. 74 1e-12
EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family... 74 1e-12
BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family... 74 1e-12
AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1 var... 74 1e-12
AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1 pro... 74 1e-12
AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family... 74 1e-12
AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein. 74 1e-12
AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family... 73 2e-12
AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2 pro... 73 2e-12
Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for ... 73 3e-12
U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein. 73 3e-12
S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein. 73 3e-12
M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein. 73 3e-12
M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein. 73 3e-12
M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein. 73 3e-12
M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein. 73 3e-12
M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein. 73 3e-12
L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrom... 73 3e-12
D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein. 73 3e-12
DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family... 73 3e-12
BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family... 73 3e-12
AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family... 73 3e-12
AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family... 73 3e-12
AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family... 73 3e-12
AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein. 73 3e-12
M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein. 72 4e-12
M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein. 71 7e-12
M12078-1|AAA52154.1| 192|Homo sapiens POR protein. 71 7e-12
BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein pr... 71 7e-12
BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein. 71 7e-12
BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family... 71 7e-12
BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family... 71 7e-12
BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family... 71 7e-12
AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family... 71 7e-12
M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein. 71 1e-11
M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein. 71 1e-11
DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family... 71 1e-11
BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family... 71 1e-11
BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family... 71 1e-11
AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family... 71 1e-11
AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6 pro... 71 1e-11
AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein. 71 1e-11
L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxyla... 71 1e-11
L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein. 71 1e-11
BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family... 71 1e-11
AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family... 71 1e-11
AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family... 71 1e-11
AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family... 71 1e-11
BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family... 70 2e-11
AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein. 70 2e-11
AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens ... 70 2e-11
AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1 pro... 70 2e-11
X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C pro... 70 2e-11
K03192-1|AAA52147.1| 331|Homo sapiens CYP1A1 protein. 70 2e-11
AF237982-1|AAF63329.1| 469|Homo sapiens oxysterol 7alpha-hydrox... 70 2e-11
J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrom... 69 3e-11
J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrom... 69 3e-11
DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family... 69 3e-11
DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1 pro... 69 3e-11
BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family... 69 3e-11
AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family... 69 3e-11
AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1 pro... 69 3e-11
AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1 pro... 69 3e-11
L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18 prot... 69 4e-11
M24667-1|AAA52148.1| 256|Homo sapiens steroid 11-beta-hydroxyla... 69 5e-11
AL591242-1|CAH73899.1| 469|Homo sapiens cytochrome P450, family... 68 9e-11
AL035670-1|CAI20276.1| 469|Homo sapiens cytochrome P450, family... 68 9e-11
AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase pr... 67 1e-10
AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase pr... 67 1e-10
M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase prot... 67 2e-10
BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase ... 67 2e-10
BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein. 67 2e-10
AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase ... 67 2e-10
AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase pr... 67 2e-10
AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase pr... 67 2e-10
AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase pr... 67 2e-10
AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase pr... 67 2e-10
AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase pr... 67 2e-10
AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase pr... 67 2e-10
AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase pr... 67 2e-10
D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase prot... 66 2e-10
BC010358-1|AAH10358.1| 469|Homo sapiens cytochrome P450, family... 66 4e-10
AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase pr... 66 4e-10
AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase pr... 66 4e-10
BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family... 65 5e-10
U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase... 65 6e-10
D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase... 65 6e-10
AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein. 65 6e-10
U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha demet... 64 1e-09
AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1 pro... 64 1e-09
Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein. 63 3e-09
M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein. 63 3e-09
M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrom... 63 3e-09
J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein. 63 3e-09
BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family... 63 3e-09
AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family... 63 3e-09
AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family... 63 3e-09
X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120... 62 3e-09
M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein. 62 5e-09
AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,... 62 5e-09
M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant 21... 62 6e-09
M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human 21-hydrox... 62 6e-09
M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein. 62 6e-09
BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family... 62 6e-09
BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family... 62 6e-09
BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family... 62 6e-09
BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family... 62 6e-09
AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,... 62 6e-09
AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,... 62 6e-09
AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,... 62 6e-09
AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,... 62 6e-09
AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,... 62 6e-09
AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,... 62 6e-09
AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family... 62 6e-09
AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family... 62 6e-09
AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, famil... 62 6e-09
AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, famil... 62 6e-09
AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, famil... 62 6e-09
AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, famil... 62 6e-09
AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P4... 62 6e-09
AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein pr... 62 6e-09
AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein. 62 6e-09
AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450 21-hydr... 62 6e-09
AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450 21-hydr... 62 6e-09
X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase ... 61 8e-09
M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein. 61 8e-09
AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,... 61 8e-09
AM233517-1|CAJ80720.1| 175|Homo sapiens cytochrome P450 1A1 pro... 61 1e-08
AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens ... 60 1e-08
AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein. 60 2e-08
M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein. 60 2e-08
AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase ... 60 2e-08
AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens ... 60 2e-08
AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family... 60 2e-08
U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein. 59 3e-08
BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family... 59 3e-08
BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family... 59 3e-08
AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein. 59 3e-08
BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein. 59 4e-08
BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein. 59 4e-08
AL138805-2|CAM27343.1| 448|Homo sapiens cytochrome P450, family... 59 4e-08
M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase pr... 58 6e-08
U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochro... 58 7e-08
AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family... 58 7e-08
AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1 ... 58 7e-08
BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family... 58 1e-07
BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein. 58 1e-07
L16883-1|AAD13467.1| 169|Homo sapiens cytochrome P-450 2C protein. 56 3e-07
BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family... 55 5e-07
BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family... 55 5e-07
AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoi... 55 5e-07
AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein. 55 5e-07
AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family... 54 9e-07
M80646-1|AAA60617.1| 460|Homo sapiens thromboxane synthase prot... 54 1e-06
DQ016495-1|AAY34975.1| 195|Homo sapiens cytochrome P450 1B1 pro... 52 4e-06
M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein. 52 5e-06
BC093022-1|AAH93022.1| 416|Homo sapiens CYP20A1 protein protein. 52 5e-06
BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein. 52 5e-06
BC033752-1|AAH33752.1| 462|Homo sapiens cytochrome P450, family... 52 5e-06
BC020616-1|AAH20616.1| 462|Homo sapiens cytochrome P450, family... 52 5e-06
AK127151-1|BAC86855.1| 146|Homo sapiens protein ( Homo sapiens ... 52 6e-06
AY359068-1|AAQ89427.1| 462|Homo sapiens P450-like protein protein. 51 8e-06
AF040259-1|AAD10199.1| 144|Homo sapiens cytochrome P450 1A1 pro... 50 3e-05
AM233518-1|CAJ80721.1| 157|Homo sapiens cytochrome P450 1A1 pro... 49 3e-05
L36085-1|AAC01761.1| 441|Homo sapiens thromboxane A2 synthase p... 49 4e-05
AF183412-1|AAG09681.1| 435|Homo sapiens cytochrome P450 monooxy... 49 4e-05
M17398-1|AAA35740.1| 393|Homo sapiens protein ( Human cytochrom... 46 2e-04
AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens ... 46 2e-04
S77409-1|AAB34643.1| 228|Homo sapiens steroid 18-hydroxylase pr... 45 6e-04
AC011737-1|AAX88915.1| 382|Homo sapiens unknown protein. 45 6e-04
X58904-1|CAA41707.1| 371|Homo sapiens steroid 21-monooxygenase ... 44 0.001
X58902-1|CAA41706.1| 372|Homo sapiens steroid 21-monooxygenase ... 44 0.001
X58900-1|CAA41704.1| 372|Homo sapiens steroid 21-monooxygenase ... 44 0.001
X58899-1|CAA41703.1| 368|Homo sapiens steroid 21-monooxygenase ... 44 0.001
X58898-1|CAA41702.1| 371|Homo sapiens steroid 21-monooxygenase ... 44 0.001
BC096286-1|AAH96286.1| 437|Homo sapiens cytochrome P450, family... 43 0.003
DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P4... 42 0.004
AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450 epoxyge... 42 0.007
AY871801-1|AAX62803.1| 483|Homo sapiens cytochrome P450 family ... 40 0.021
AJ877238-1|CAI47002.1| 97|Homo sapiens putative cytochrome P45... 40 0.021
AL358613-1|CAH72802.2| 522|Homo sapiens cytochrome P450, family... 39 0.048
BC128535-1|AAI28536.1| 143|Homo sapiens LOC283480 protein protein. 38 0.084
AY356349-1|AAQ55485.1| 522|Homo sapiens cytochrome P450 protein. 37 0.15
AK094090-1|BAC04283.1| 153|Homo sapiens protein ( Homo sapiens ... 36 0.26
M19267-1|AAA36771.1| 284|Homo sapiens protein ( Human tropomyos... 33 1.8
BC007433-1|AAH07433.1| 284|Homo sapiens tropomyosin 1 (alpha) p... 33 1.8
AY572488-1|AAS78571.1| 2136|Homo sapiens 200 kDa U5 snRNP-specif... 33 1.8
AK090671-1|BAC03499.1| 625|Homo sapiens protein ( Homo sapiens ... 33 1.8
Z24727-1|CAA80853.1| 243|Homo sapiens tropomyosin isoform protein. 33 3.2
AK124171-1|BAC85794.1| 534|Homo sapiens protein ( Homo sapiens ... 33 3.2
M19715-1|AAA61227.1| 229|Homo sapiens TPM1 protein. 32 5.5
DQ424903-1|ABD83668.1| 245|Homo sapiens tropomyosin 1 alpha var... 32 5.5
AF474156-1|AAL84569.1| 203|Homo sapiens TPMsk1 protein. 32 5.5
AF435011-1|AAL33548.1| 6885|Homo sapiens NUANCE protein. 32 5.5
AF495911-1|AAN60443.1| 6884|Homo sapiens nesprin-2 protein. 31 9.6
>BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family 4,
subfamily V, polypeptide 2 protein.
Length = 525
Score = 153 bits (372), Expect = 1e-36
Identities = 98/318 (30%), Positives = 166/318 (52%), Gaps = 12/318 (3%)
Query: 204 TAFGVYTNEDENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
TA G N Y+ AV + +I +R WL +D Y + + ++I++
Sbjct: 203 TAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILH 262
Query: 264 EMSNKIIARKRSELASGVAAANE------TDNKYQGLLDLMLKLAKEDA--LTDQEIREE 315
+N +IA + +E+ + + + NK + LDL+L + ++ L+ ++IREE
Sbjct: 263 TFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREE 322
Query: 316 VDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTE 375
VDT + G DT++ + + L LGS PEVQ + +E+ DVFG SDR EDL KL Y E
Sbjct: 323 VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLE 382
Query: 376 AVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPE 435
V+KET+RL+ P+ R + ED ++ + + GT+ I + ++R + + EF+PE
Sbjct: 383 CVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPE 442
Query: 436 RWL--DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK--LDFK 491
R+ + Q A+ FS G R+C G+ +A+ K L+ +LR + I + + L +
Sbjct: 443 RFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLE 502
Query: 492 FNFIIKPISGSEIGLEYR 509
I++P +G I L+ R
Sbjct: 503 GQLILRPSNGIWIKLKRR 520
Score = 116 bits (280), Expect = 1e-25
Identities = 57/157 (36%), Positives = 91/157 (57%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
+I EE++T +F G+DTT+ + + L LG+ +VQ+K+ E+ +VFG S+R +DL K
Sbjct: 318 DIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKK 377
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L Y E VIKE+LRL+P P+ R + +D ++ Y + G I Y ++R + + +
Sbjct: 378 LRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPE 437
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+F+PER+ + YA+ F G R CIG F V
Sbjct: 438 EFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAV 474
>AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2
protein.
Length = 525
Score = 153 bits (372), Expect = 1e-36
Identities = 98/318 (30%), Positives = 166/318 (52%), Gaps = 12/318 (3%)
Query: 204 TAFGVYTNEDENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
TA G N Y+ AV + +I +R WL +D Y + + ++I++
Sbjct: 203 TAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILH 262
Query: 264 EMSNKIIARKRSELASGVAAANE------TDNKYQGLLDLMLKLAKEDA--LTDQEIREE 315
+N +IA + +E+ + + + NK + LDL+L + ++ L+ ++IREE
Sbjct: 263 TFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREE 322
Query: 316 VDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTE 375
VDT + G DT++ + + L LGS PEVQ + +E+ DVFG SDR EDL KL Y E
Sbjct: 323 VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLE 382
Query: 376 AVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPE 435
V+KET+RL+ P+ R + ED ++ + + GT+ I + ++R + + EF+PE
Sbjct: 383 CVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPE 442
Query: 436 RWL--DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK--LDFK 491
R+ + Q A+ FS G R+C G+ +A+ K L+ +LR + I + + L +
Sbjct: 443 RFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLE 502
Query: 492 FNFIIKPISGSEIGLEYR 509
I++P +G I L+ R
Sbjct: 503 GQLILRPSNGIWIKLKRR 520
Score = 116 bits (280), Expect = 1e-25
Identities = 57/157 (36%), Positives = 91/157 (57%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
+I EE++T +F G+DTT+ + + L LG+ +VQ+K+ E+ +VFG S+R +DL K
Sbjct: 318 DIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKK 377
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L Y E VIKE+LRL+P P+ R + +D ++ Y + G I Y ++R + + +
Sbjct: 378 LRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPE 437
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+F+PER+ + YA+ F G R CIG F V
Sbjct: 438 EFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAV 474
>AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens
cDNA FLJ44509 fis, clone UTERU3001585, weakly similar
to Cytochrome P450 4c3 (EC 1.14.-.-). ).
Length = 503
Score = 153 bits (372), Expect = 1e-36
Identities = 98/318 (30%), Positives = 166/318 (52%), Gaps = 12/318 (3%)
Query: 204 TAFGVYTNEDENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
TA G N Y+ AV + +I +R WL +D Y + + ++I++
Sbjct: 181 TAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILH 240
Query: 264 EMSNKIIARKRSELASGVAAANE------TDNKYQGLLDLMLKLAKEDA--LTDQEIREE 315
+N +IA + +E+ + + + NK + LDL+L + ++ L+ ++IREE
Sbjct: 241 TFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREE 300
Query: 316 VDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTE 375
VDT + G DT++ + + L LGS PEVQ + +E+ DVFG SDR EDL KL Y E
Sbjct: 301 VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLE 360
Query: 376 AVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPE 435
V+KET+RL+ P+ R + ED ++ + + GT+ I + ++R + + EF+PE
Sbjct: 361 CVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPE 420
Query: 436 RWL--DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK--LDFK 491
R+ + Q A+ FS G R+C G+ +A+ K L+ +LR + I + + L +
Sbjct: 421 RFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLE 480
Query: 492 FNFIIKPISGSEIGLEYR 509
I++P +G I L+ R
Sbjct: 481 GQLILRPSNGIWIKLKRR 498
Score = 116 bits (280), Expect = 1e-25
Identities = 57/157 (36%), Positives = 91/157 (57%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
+I EE++T +F G+DTT+ + + L LG+ +VQ+K+ E+ +VFG S+R +DL K
Sbjct: 296 DIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKK 355
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L Y E VIKE+LRL+P P+ R + +D ++ Y + G I Y ++R + + +
Sbjct: 356 LRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPE 415
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+F+PER+ + YA+ F G R CIG F V
Sbjct: 416 EFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAV 452
>AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens
cDNA FLJ16007 fis, clone KIDNE2006580, weakly similar
to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
Length = 525
Score = 153 bits (372), Expect = 1e-36
Identities = 98/318 (30%), Positives = 166/318 (52%), Gaps = 12/318 (3%)
Query: 204 TAFGVYTNEDENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
TA G N Y+ AV + +I +R WL +D Y + + ++I++
Sbjct: 203 TAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILH 262
Query: 264 EMSNKIIARKRSELASGVAAANE------TDNKYQGLLDLMLKLAKEDA--LTDQEIREE 315
+N +IA + +E+ + + + NK + LDL+L + ++ L+ ++IREE
Sbjct: 263 TFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREE 322
Query: 316 VDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTE 375
VDT + G DT++ + + L LGS PEVQ + +E+ DVFG SDR EDL KL Y E
Sbjct: 323 VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLE 382
Query: 376 AVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPE 435
V+KET+RL+ P+ R + ED ++ + + GT+ I + ++R + + EF+PE
Sbjct: 383 CVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPE 442
Query: 436 RWL--DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK--LDFK 491
R+ + Q A+ FS G R+C G+ +A+ K L+ +LR + I + + L +
Sbjct: 443 RFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLE 502
Query: 492 FNFIIKPISGSEIGLEYR 509
I++P +G I L+ R
Sbjct: 503 GQLILRPSNGIWIKLKRR 520
Score = 116 bits (280), Expect = 1e-25
Identities = 57/157 (36%), Positives = 91/157 (57%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
+I EE++T +F G+DTT+ + + L LG+ +VQ+K+ E+ +VFG S+R +DL K
Sbjct: 318 DIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKK 377
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L Y E VIKE+LRL+P P+ R + +D ++ Y + G I Y ++R + + +
Sbjct: 378 LRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPE 437
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+F+PER+ + YA+ F G R CIG F V
Sbjct: 438 EFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAV 474
>U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein.
Length = 520
Score = 144 bits (348), Expect = 9e-34
Identities = 90/298 (30%), Positives = 165/298 (55%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ +++KR + L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ +L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASVLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL+ L + +KE++R++ PV R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRVHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
H+ +D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 HVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+ +A+ MK+ LA L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 91.9 bits (218), Expect = 5e-18
Identities = 52/161 (32%), Positives = 94/161 (58%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASVLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
L + +KESLR++P P+I R + QD+ + + + G C I+V+G + + A+W
Sbjct: 377 HLPFLTMCMKESLRVHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P+ + AF F G R CIG F +
Sbjct: 436 DPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAM 475
>BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 143 bits (346), Expect = 2e-33
Identities = 91/298 (30%), Positives = 164/298 (55%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ +++KR + L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL+ L + +KE++RL+ PV R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
H+ +D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 HVTQDIVLPDGRVIPKGIICLISVFGTHHNPAMWPDPEVYDPFRF-DPENIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+ +A+ MK+ LA L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 93.9 bits (223), Expect = 1e-18
Identities = 54/161 (33%), Positives = 94/161 (58%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
L + +KESLRL+P P+I R + QD+ + + + G C I+V+G + + AMW
Sbjct: 377 HLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAMW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P+ + AF F G R CIG F +
Sbjct: 436 DPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAM 475
>AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 143 bits (346), Expect = 2e-33
Identities = 91/298 (30%), Positives = 164/298 (55%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ +++KR + L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL+ L + +KE++RL+ PV R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
H+ +D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 HVTQDIVLPDGRVIPKGIICLISVFGTHHNPAMWPDPEVYDPFRF-DPENIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+ +A+ MK+ LA L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 93.9 bits (223), Expect = 1e-18
Identities = 54/161 (33%), Positives = 94/161 (58%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
L + +KESLRL+P P+I R + QD+ + + + G C I+V+G + + AMW
Sbjct: 377 HLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAMW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P+ + AF F G R CIG F +
Sbjct: 436 DPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAM 475
>D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 142 bits (344), Expect = 3e-33
Identities = 91/298 (30%), Positives = 164/298 (55%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ +++KR + L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL+ L + +KE++RL+ PV R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
H+ +D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 HVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+ +A+ MK+ LA L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 92.3 bits (219), Expect = 4e-18
Identities = 53/161 (32%), Positives = 94/161 (58%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
L + +KESLRL+P P+I R + QD+ + + + G C I+V+G + + A+W
Sbjct: 377 HLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P+ + AF F G R CIG F +
Sbjct: 436 DPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAM 475
>BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 142 bits (344), Expect = 3e-33
Identities = 91/298 (30%), Positives = 164/298 (55%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ +++KR + L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL+ L + +KE++RL+ PV R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
H+ +D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 HVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+ +A+ MK+ LA L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 92.3 bits (219), Expect = 4e-18
Identities = 53/161 (32%), Positives = 94/161 (58%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
L + +KESLRL+P P+I R + QD+ + + + G C I+V+G + + A+W
Sbjct: 377 HLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P+ + AF F G R CIG F +
Sbjct: 436 DPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAM 475
>BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 142 bits (344), Expect = 3e-33
Identities = 91/298 (30%), Positives = 164/298 (55%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ +++KR + L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL+ L + +KE++RL+ PV R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
H+ +D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 HVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+ +A+ MK+ LA L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 92.3 bits (219), Expect = 4e-18
Identities = 53/161 (32%), Positives = 94/161 (58%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
L + +KESLRL+P P+I R + QD+ + + + G C I+V+G + + A+W
Sbjct: 377 HLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P+ + AF F G R CIG F +
Sbjct: 436 DPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAM 475
>AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfamily
IVF, polypeptide 2 protein.
Length = 520
Score = 142 bits (344), Expect = 3e-33
Identities = 91/298 (30%), Positives = 164/298 (55%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ +++KR + L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL+ L + +KE++RL+ PV R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
H+ +D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 HVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+ +A+ MK+ LA L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 92.3 bits (219), Expect = 4e-18
Identities = 53/161 (32%), Positives = 94/161 (58%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
L + +KESLRL+P P+I R + QD+ + + + G C I+V+G + + A+W
Sbjct: 377 HLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P+ + AF F G R CIG F +
Sbjct: 436 DPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAM 475
>AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein.
Length = 520
Score = 142 bits (344), Expect = 3e-33
Identities = 91/298 (30%), Positives = 164/298 (55%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ +++KR + L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL+ L + +KE++RL+ PV R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
H+ +D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 HVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPENIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+ +A+ MK+ LA L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 92.3 bits (219), Expect = 4e-18
Identities = 53/161 (32%), Positives = 94/161 (58%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
L + +KESLRL+P P+I R + QD+ + + + G C I+V+G + + A+W
Sbjct: 377 HLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P+ + AF F G R CIG F +
Sbjct: 436 DPEVYDPFRF-DPENIKERSPLAFIPFSAGPRNCIGQTFAM 475
>AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 3 protein.
Length = 520
Score = 137 bits (331), Expect = 1e-31
Identities = 90/298 (30%), Positives = 163/298 (54%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ ++TKR ++ L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
+D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 CCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ L L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 90.2 bits (214), Expect = 1e-17
Identities = 54/161 (33%), Positives = 93/161 (57%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
+L + IKESLRL+P P + R QD+ + + + G C I+V+G + + A+W
Sbjct: 377 QLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P + AF F G R CIG AF +
Sbjct: 436 DPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAM 475
>AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein.
Length = 520
Score = 137 bits (331), Expect = 1e-31
Identities = 90/298 (30%), Positives = 163/298 (54%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ ++TKR ++ L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
+D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 CCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ L L ++++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELVLRAEGGIWLRVE 517
Score = 90.2 bits (214), Expect = 1e-17
Identities = 54/161 (33%), Positives = 93/161 (57%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
+L + IKESLRL+P P + R QD+ + + + G C I+V+G + + A+W
Sbjct: 377 QLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P + AF F G R CIG AF +
Sbjct: 436 DPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAM 475
>D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV
protein.
Length = 520
Score = 136 bits (328), Expect = 2e-31
Identities = 90/298 (30%), Positives = 162/298 (54%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ ++TKR ++ L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
+D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 CCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ L L +++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 90.2 bits (214), Expect = 1e-17
Identities = 54/161 (33%), Positives = 93/161 (57%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
+L + IKESLRL+P P + R QD+ + + + G C I+V+G + + A+W
Sbjct: 377 QLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P + AF F G R CIG AF +
Sbjct: 436 DPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAM 475
>AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 136 bits (328), Expect = 2e-31
Identities = 90/298 (30%), Positives = 162/298 (54%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ ++TKR ++ L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
+D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 CCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ L L +++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 90.2 bits (214), Expect = 1e-17
Identities = 54/161 (33%), Positives = 93/161 (57%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
+L + IKESLRL+P P + R QD+ + + + G C I+V+G + + A+W
Sbjct: 377 QLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P + AF F G R CIG AF +
Sbjct: 436 DPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAM 475
>AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 136 bits (328), Expect = 2e-31
Identities = 90/298 (30%), Positives = 162/298 (54%), Gaps = 11/298 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ ++TKR ++ L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q+R E+ ++ D + +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN---AFA 449
+D+ L + + G C IS+FG + + D + P R+ DP+ I + AF
Sbjct: 401 CCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF-DPKNIKERSPLAFI 459
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ L L +++ D ++ K +++ G + +E
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVLPDHTEPRRKPELVLRAEGGLWLRVE 517
Score = 90.2 bits (214), Expect = 1e-17
Identities = 54/161 (33%), Positives = 93/161 (57%), Gaps = 6/161 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGD 168
+L + IKESLRL+P P + R QD+ + + + G C I+V+G + + A+W
Sbjct: 377 QLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-P 435
Query: 169 DADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
D + + P R+ +P + AF F G R CIG AF +
Sbjct: 436 DPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAM 475
>BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 133 bits (322), Expect = 1e-30
Identities = 90/311 (28%), Positives = 158/311 (50%), Gaps = 10/311 (3%)
Query: 205 AFGVYTNEDENFTK-AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
AF TN N T Y A+ E+ II R + D I+ L+ R +L R++N
Sbjct: 196 AFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLN 255
Query: 264 EMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIM 321
+ ++ II ++ L +GV N KYQ LD++L E + +D ++ EV T ++
Sbjct: 256 QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLL 315
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG DT + + ++L L PE Q+R E+ + GD + + L ++ YT +KET
Sbjct: 316 AGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGEMSYTTMCIKET 374
Query: 382 MRLYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL-- 438
RL P R + + + + TL AG +S++G++ + ++ F P R+
Sbjct: 375 CRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQE 434
Query: 439 -DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK-LDFKFNFII 496
Q+ P A+ FS G R+C G+ +A+ +K+ +A +L ++++ D ++ L F +FI+
Sbjct: 435 NSDQRHP-YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFIL 493
Query: 497 KPISGSEIGLE 507
KP +G + L+
Sbjct: 494 KPKNGMYLHLK 504
Score = 81.4 bits (192), Expect = 7e-15
Identities = 45/159 (28%), Positives = 85/159 (53%), Gaps = 4/159 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T + G+DT + +++++L L + Q++ EE++ + GD + D L +
Sbjct: 305 DVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGE 363
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGDD 169
+ YT IKE+ RL P P I R+L + + + TL AG ++++G++ + A+W +
Sbjct: 364 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KN 422
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + + YA+ F G R CIG F +
Sbjct: 423 PKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAM 461
>AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein.
Length = 509
Score = 133 bits (322), Expect = 1e-30
Identities = 90/311 (28%), Positives = 158/311 (50%), Gaps = 10/311 (3%)
Query: 205 AFGVYTNEDENFTK-AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
AF TN N T Y A+ E+ II R + D I+ L+ R +L R++N
Sbjct: 196 AFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLN 255
Query: 264 EMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIM 321
+ ++ II ++ L +GV N KYQ LD++L E + +D ++ EV T ++
Sbjct: 256 QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLL 315
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG DT + + ++L L PE Q+R E+ + GD + + L ++ YT +KET
Sbjct: 316 AGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGEMSYTTMCIKET 374
Query: 382 MRLYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL-- 438
RL P R + + + + TL AG +S++G++ + ++ F P R+
Sbjct: 375 CRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQE 434
Query: 439 -DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK-LDFKFNFII 496
Q+ P A+ FS G R+C G+ +A+ +K+ +A +L ++++ D ++ L F +FI+
Sbjct: 435 NSDQRHP-YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFIL 493
Query: 497 KPISGSEIGLE 507
KP +G + L+
Sbjct: 494 KPKNGMYLHLK 504
Score = 81.4 bits (192), Expect = 7e-15
Identities = 45/159 (28%), Positives = 85/159 (53%), Gaps = 4/159 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T + G+DT + +++++L L + Q++ EE++ + GD + D L +
Sbjct: 305 DVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGE 363
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGDD 169
+ YT IKE+ RL P P I R+L + + + TL AG ++++G++ + A+W +
Sbjct: 364 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KN 422
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + + YA+ F G R CIG F +
Sbjct: 423 PKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAM 461
>AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein.
Length = 509
Score = 133 bits (322), Expect = 1e-30
Identities = 90/311 (28%), Positives = 158/311 (50%), Gaps = 10/311 (3%)
Query: 205 AFGVYTNEDENFTK-AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
AF TN N T Y A+ E+ II R + D I+ L+ R +L R++N
Sbjct: 196 AFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLN 255
Query: 264 EMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIM 321
+ ++ II ++ L +GV N KYQ LD++L E + +D ++ EV T ++
Sbjct: 256 QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLL 315
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG DT + + ++L L PE Q+R E+ + GD + + L ++ YT +KET
Sbjct: 316 AGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGEMSYTTMCIKET 374
Query: 382 MRLYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL-- 438
RL P R + + + + TL AG +S++G++ + ++ F P R+
Sbjct: 375 CRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQE 434
Query: 439 -DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK-LDFKFNFII 496
Q+ P A+ FS G R+C G+ +A+ +K+ +A +L ++++ D ++ L F +FI+
Sbjct: 435 NSDQRHP-YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFIL 493
Query: 497 KPISGSEIGLE 507
KP +G + L+
Sbjct: 494 KPKNGMYLHLK 504
Score = 81.4 bits (192), Expect = 7e-15
Identities = 45/159 (28%), Positives = 85/159 (53%), Gaps = 4/159 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T + G+DT + +++++L L + Q++ EE++ + GD + D L +
Sbjct: 305 DVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGE 363
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGDD 169
+ YT IKE+ RL P P I R+L + + + TL AG ++++G++ + A+W +
Sbjct: 364 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KN 422
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + + YA+ F G R CIG F +
Sbjct: 423 PKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAM 461
>AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 133 bits (322), Expect = 1e-30
Identities = 90/311 (28%), Positives = 158/311 (50%), Gaps = 10/311 (3%)
Query: 205 AFGVYTNEDENFTK-AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
AF TN N T Y A+ E+ II R + D I+ L+ R +L R++N
Sbjct: 196 AFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLN 255
Query: 264 EMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIM 321
+ ++ II ++ L +GV N KYQ LD++L E + +D ++ EV T ++
Sbjct: 256 QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLL 315
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG DT + + ++L L PE Q+R E+ + GD + + L ++ YT +KET
Sbjct: 316 AGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGEMSYTTMCIKET 374
Query: 382 MRLYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL-- 438
RL P R + + + + TL AG +S++G++ + ++ F P R+
Sbjct: 375 CRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQE 434
Query: 439 -DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK-LDFKFNFII 496
Q+ P A+ FS G R+C G+ +A+ +K+ +A +L ++++ D ++ L F +FI+
Sbjct: 435 NSDQRHP-YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFIL 493
Query: 497 KPISGSEIGLE 507
KP +G + L+
Sbjct: 494 KPKNGMYLHLK 504
Score = 81.4 bits (192), Expect = 7e-15
Identities = 45/159 (28%), Positives = 85/159 (53%), Gaps = 4/159 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T + G+DT + +++++L L + Q++ EE++ + GD + D L +
Sbjct: 305 DVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGE 363
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGDD 169
+ YT IKE+ RL P P I R+L + + + TL AG ++++G++ + A+W +
Sbjct: 364 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KN 422
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + + YA+ F G R CIG F +
Sbjct: 423 PKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAM 461
>AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens
cDNA FLJ16384 fis, clone TLIVE2007607, weakly similar
to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 508
Score = 133 bits (322), Expect = 1e-30
Identities = 90/311 (28%), Positives = 158/311 (50%), Gaps = 10/311 (3%)
Query: 205 AFGVYTNEDENFTK-AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
AF TN N T Y A+ E+ II R + D I+ L+ R +L R++N
Sbjct: 195 AFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLN 254
Query: 264 EMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIM 321
+ ++ II ++ L +GV N KYQ LD++L E + +D ++ EV T ++
Sbjct: 255 QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLL 314
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG DT + + ++L L PE Q+R E+ + GD + + L ++ YT +KET
Sbjct: 315 AGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGEMSYTTMCIKET 373
Query: 382 MRLYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL-- 438
RL P R + + + + TL AG +S++G++ + ++ F P R+
Sbjct: 374 CRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQE 433
Query: 439 -DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK-LDFKFNFII 496
Q+ P A+ FS G R+C G+ +A+ +K+ +A +L ++++ D ++ L F +FI+
Sbjct: 434 NSDQRHP-YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFIL 492
Query: 497 KPISGSEIGLE 507
KP +G + L+
Sbjct: 493 KPKNGMYLHLK 503
Score = 81.4 bits (192), Expect = 7e-15
Identities = 45/159 (28%), Positives = 85/159 (53%), Gaps = 4/159 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T + G+DT + +++++L L + Q++ EE++ + GD + D L +
Sbjct: 304 DVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGE 362
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGDD 169
+ YT IKE+ RL P P I R+L + + + TL AG ++++G++ + A+W +
Sbjct: 363 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KN 421
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + + YA+ F G R CIG F +
Sbjct: 422 PKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAM 460
>AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens
cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 509
Score = 133 bits (322), Expect = 1e-30
Identities = 90/311 (28%), Positives = 158/311 (50%), Gaps = 10/311 (3%)
Query: 205 AFGVYTNEDENFTK-AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
AF TN N T Y A+ E+ II R + D I+ L+ R +L R++N
Sbjct: 196 AFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLN 255
Query: 264 EMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIM 321
+ ++ II ++ L +GV N KYQ LD++L E + +D ++ EV T ++
Sbjct: 256 QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLL 315
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG DT + + ++L L PE Q+R E+ + GD + + L ++ YT +KET
Sbjct: 316 AGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGEMSYTTMCIKET 374
Query: 382 MRLYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL-- 438
RL P R + + + + TL AG +S++G++ + ++ F P R+
Sbjct: 375 CRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQE 434
Query: 439 -DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK-LDFKFNFII 496
Q+ P A+ FS G R+C G+ +A+ +K+ +A +L ++++ D ++ L F +FI+
Sbjct: 435 NSDQRHP-YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFIL 493
Query: 497 KPISGSEIGLE 507
KP +G + L+
Sbjct: 494 KPKNGMYLHLK 504
Score = 81.4 bits (192), Expect = 7e-15
Identities = 45/159 (28%), Positives = 85/159 (53%), Gaps = 4/159 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T + G+DT + +++++L L + Q++ EE++ + GD + D L +
Sbjct: 305 DVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGE 363
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGDD 169
+ YT IKE+ RL P P I R+L + + + TL AG ++++G++ + A+W +
Sbjct: 364 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KN 422
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + + YA+ F G R CIG F +
Sbjct: 423 PKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAM 461
>AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens
cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 444
Score = 133 bits (322), Expect = 1e-30
Identities = 90/311 (28%), Positives = 158/311 (50%), Gaps = 10/311 (3%)
Query: 205 AFGVYTNEDENFTK-AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVN 263
AF TN N T Y A+ E+ II R + D I+ L+ R +L R++N
Sbjct: 131 AFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLN 190
Query: 264 EMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIM 321
+ ++ II ++ L +GV N KYQ LD++L E + +D ++ EV T ++
Sbjct: 191 QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLL 250
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG DT + + ++L L PE Q+R E+ + GD + + L ++ YT +KET
Sbjct: 251 AGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGEMSYTTMCIKET 309
Query: 382 MRLYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL-- 438
RL P R + + + + TL AG +S++G++ + ++ F P R+
Sbjct: 310 CRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQE 369
Query: 439 -DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK-LDFKFNFII 496
Q+ P A+ FS G R+C G+ +A+ +K+ +A +L ++++ D ++ L F +FI+
Sbjct: 370 NSDQRHP-YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFIL 428
Query: 497 KPISGSEIGLE 507
KP +G + L+
Sbjct: 429 KPKNGMYLHLK 439
Score = 81.4 bits (192), Expect = 7e-15
Identities = 45/159 (28%), Positives = 85/159 (53%), Gaps = 4/159 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T + G+DT + +++++L L + Q++ EE++ + GD + D L +
Sbjct: 240 DVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SITWDQLGE 298
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRH-AMWGDD 169
+ YT IKE+ RL P P I R+L + + + TL AG ++++G++ + A+W +
Sbjct: 299 MSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW-KN 357
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + + YA+ F G R CIG F +
Sbjct: 358 PKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAM 396
>BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 12 protein.
Length = 524
Score = 132 bits (318), Expect = 4e-30
Identities = 87/299 (29%), Positives = 160/299 (53%), Gaps = 13/299 (4%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++ + E+ ++ KR + +DF+Y L+ +R R+V++ ++ +I +R L +
Sbjct: 221 YIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPT 280
Query: 280 -GVAA--ANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYV 334
G+ ++ +K +D++L ED AL+D++IR E DT + G DT++ L +V
Sbjct: 281 QGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L NL PE Q+R E+ ++ D D +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERWLDPQKIPDN---AF 448
+D+ L + + G C I + G++ + TVW D + P R+ DP+ AF
Sbjct: 401 CCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVW-PDPEVYDPFRF-DPENSKGRSPLAF 458
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ LA +L ++ D ++ K I++ G + +E
Sbjct: 459 IPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
Score = 97.1 bits (231), Expect = 1e-19
Identities = 52/159 (32%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +FGG+DTT+ L++VL NL + + Q++ +E++ + D + +++E DDL+
Sbjct: 317 DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L + +KESLRL+P AP I R QD+ + + + G C I++ G++ + D
Sbjct: 377 QLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPD 436
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ + P R+ + AF F G R CIG AF +
Sbjct: 437 PEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAM 475
>AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein.
Length = 524
Score = 132 bits (318), Expect = 4e-30
Identities = 87/299 (29%), Positives = 160/299 (53%), Gaps = 13/299 (4%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++ + E+ ++ KR + +DF+Y L+ +R R+V++ ++ +I +R L +
Sbjct: 221 YIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPT 280
Query: 280 -GVAA--ANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYV 334
G+ ++ +K +D++L ED AL+D++IR E DT + G DT++ L +V
Sbjct: 281 QGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L NL PE Q+R E+ ++ D D +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERWLDPQKIPDN---AF 448
+D+ L + + G C I + G++ + TVW D + P R+ DP+ AF
Sbjct: 401 CCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVW-PDPEVYDPFRF-DPENSKGRSPLAF 458
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ LA +L ++ D ++ K I++ G + +E
Sbjct: 459 IPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
Score = 97.1 bits (231), Expect = 1e-19
Identities = 52/159 (32%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +FGG+DTT+ L++VL NL + + Q++ +E++ + D + +++E DDL+
Sbjct: 317 DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L + +KESLRL+P AP I R QD+ + + + G C I++ G++ + D
Sbjct: 377 QLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPD 436
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ + P R+ + AF F G R CIG AF +
Sbjct: 437 PEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAM 475
>AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform
4F12 protein.
Length = 524
Score = 132 bits (318), Expect = 4e-30
Identities = 87/299 (29%), Positives = 160/299 (53%), Gaps = 13/299 (4%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++ + E+ ++ KR + +DF+Y L+ +R R+V++ ++ +I +R L +
Sbjct: 221 YIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPT 280
Query: 280 -GVAA--ANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYV 334
G+ ++ +K +D++L ED AL+D++IR E DT + G DT++ L +V
Sbjct: 281 QGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L NL PE Q+R E+ ++ D D +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERWLDPQKIPDN---AF 448
+D+ L + + G C I + G++ + TVW D + P R+ DP+ AF
Sbjct: 401 CCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVW-PDPEVYDPFRF-DPENSKGRSPLAF 458
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ LA +L ++ D ++ K I++ G + +E
Sbjct: 459 IPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
Score = 97.1 bits (231), Expect = 1e-19
Identities = 52/159 (32%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +FGG+DTT+ L++VL NL + + Q++ +E++ + D + +++E DDL+
Sbjct: 317 DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L + +KESLRL+P AP I R QD+ + + + G C I++ G++ + D
Sbjct: 377 QLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPD 436
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ + P R+ + AF F G R CIG AF +
Sbjct: 437 PEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAM 475
>AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein.
Length = 458
Score = 132 bits (318), Expect = 4e-30
Identities = 87/299 (29%), Positives = 160/299 (53%), Gaps = 13/299 (4%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++ + E+ ++ KR + +DF+Y L+ +R R+V++ ++ +I +R L +
Sbjct: 155 YIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPT 214
Query: 280 -GVAA--ANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYV 334
G+ ++ +K +D++L ED AL+D++IR E DT + G DT++ L +V
Sbjct: 215 QGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWV 274
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L NL PE Q+R E+ ++ D D +++E +DL++L + +KE++RL+ P R
Sbjct: 275 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 334
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERWLDPQKIPDN---AF 448
+D+ L + + G C I + G++ + TVW D + P R+ DP+ AF
Sbjct: 335 CCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVW-PDPEVYDPFRF-DPENSKGRSPLAF 392
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ LA +L ++ D ++ K I++ G + +E
Sbjct: 393 IPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 451
Score = 97.1 bits (231), Expect = 1e-19
Identities = 52/159 (32%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +FGG+DTT+ L++VL NL + + Q++ +E++ + D + +++E DDL+
Sbjct: 251 DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLA 310
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L + +KESLRL+P AP I R QD+ + + + G C I++ G++ + D
Sbjct: 311 QLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPD 370
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ + P R+ + AF F G R CIG AF +
Sbjct: 371 PEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAM 409
>AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 132 bits (318), Expect = 4e-30
Identities = 87/299 (29%), Positives = 160/299 (53%), Gaps = 13/299 (4%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++ + E+ ++ KR + +DF+Y L+ +R R+V++ ++ +I +R L +
Sbjct: 221 YIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPT 280
Query: 280 -GVAA--ANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYV 334
G+ ++ +K +D++L ED AL+D++IR E DT + G DT++ L +V
Sbjct: 281 QGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L NL PE Q+R E+ ++ D D +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERWLDPQKIPDN---AF 448
+D+ L + + G C I + G++ + TVW D + P R+ DP+ AF
Sbjct: 401 CCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVW-PDPEVYDPFRF-DPENSKGRSPLAF 458
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ LA +L ++ D ++ K I++ G + +E
Sbjct: 459 IPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
Score = 97.1 bits (231), Expect = 1e-19
Identities = 52/159 (32%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +FGG+DTT+ L++VL NL + + Q++ +E++ + D + +++E DDL+
Sbjct: 317 DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L + +KESLRL+P AP I R QD+ + + + G C I++ G++ + D
Sbjct: 377 QLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPD 436
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ + P R+ + AF F G R CIG AF +
Sbjct: 437 PEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAM 475
>AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 132 bits (318), Expect = 4e-30
Identities = 87/299 (29%), Positives = 160/299 (53%), Gaps = 13/299 (4%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++ + E+ ++ KR + +DF+Y L+ +R R+V++ ++ +I +R L +
Sbjct: 221 YIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPT 280
Query: 280 -GVAA--ANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYV 334
G+ ++ +K +D++L ED AL+D++IR E DT + G DT++ L +V
Sbjct: 281 QGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L NL PE Q+R E+ ++ D D +++E +DL++L + +KE++RL+ P R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERWLDPQKIPDN---AF 448
+D+ L + + G C I + G++ + TVW D + P R+ DP+ AF
Sbjct: 401 CCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVW-PDPEVYDPFRF-DPENSKGRSPLAF 458
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSEIGLE 507
FS G R+C G+A+A+ MK+ LA +L ++ D ++ K I++ G + +E
Sbjct: 459 IPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
Score = 97.1 bits (231), Expect = 1e-19
Identities = 52/159 (32%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +FGG+DTT+ L++VL NL + + Q++ +E++ + D + +++E DDL+
Sbjct: 317 DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L + +KESLRL+P AP I R QD+ + + + G C I++ G++ + D
Sbjct: 377 QLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPD 436
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ + P R+ + AF F G R CIG AF +
Sbjct: 437 PEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAM 475
>AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein.
Length = 520
Score = 130 bits (315), Expect = 9e-30
Identities = 89/276 (32%), Positives = 151/276 (54%), Gaps = 13/276 (4%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ ++ KR + + DF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTS 280
Query: 280 -GVAAANETDNKYQGLLDLMLKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L + + L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L NL PE Q+R E+ ++ D + +++E +DL++L + LKE++RL+ P R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFAR 400
Query: 394 HIEEDVKLKNF-TLKAGTDCSISLFGINRH-TVWGEDVNEFKPERWLDP---QKIPDNAF 448
+DV L + + G C+I++F I+ + +VW D + P R+ DP QK AF
Sbjct: 401 GCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVW-PDPEVYDPFRF-DPENAQKRSPMAF 458
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGD 484
FS G R+C G+ +A+ MK+ LA L +++I D
Sbjct: 459 IPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPD 494
Score = 95.9 bits (228), Expect = 3e-19
Identities = 52/159 (32%), Positives = 88/159 (55%), Gaps = 2/159 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +FGG+DTT+ L++VL NL + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L + +KESLRL+P P R QDV + ++ + G C IN++ I+ + D
Sbjct: 377 QLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPD 436
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ + P R+ + AF F G R CIG F +
Sbjct: 437 PEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAM 475
>BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 128 bits (309), Expect = 5e-29
Identities = 88/309 (28%), Positives = 163/309 (52%), Gaps = 11/309 (3%)
Query: 209 YTNEDENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNK 268
Y + + Y+SA+ E+ + +R R+ +DFIY ++ +R + +V+ + +
Sbjct: 218 YNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTE 277
Query: 269 IIARKRSELASGVAAA--NETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGF 324
+I +R L A A K +D++L ED L+D++IR E DT + G
Sbjct: 278 VIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGH 337
Query: 325 DTSSWILVYVLVNLGSFPEVQDRAYNEIMDVF-GDSDRDLEKEDLSKLVYTEAVLKETMR 383
DT+S + ++L NL +PE Q++ EI +V G +LE +DL++L +T +KE++R
Sbjct: 338 DTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLR 397
Query: 384 LYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERW--LD 439
Y + R ED+KL + + G C +S++G + + TVW D + P R+ +
Sbjct: 398 QYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVW-PDSKVYNPYRFDPDN 456
Query: 440 PQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGD-VSKLDFKFNFIIKP 498
PQ+ A+ FS G R+C G+++A+ +++ +A L ++++S D K+ K I++
Sbjct: 457 PQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRT 516
Query: 499 ISGSEIGLE 507
+G + +E
Sbjct: 517 ENGLWLKVE 525
Score = 97.1 bits (231), Expect = 1e-19
Identities = 54/160 (33%), Positives = 90/160 (56%), Gaps = 4/160 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVF-GDSERDVESDDLS 110
+I E +T +F G+DTTS ++++L NL Y + Q+K EEI+ V G ++E DDL+
Sbjct: 324 DIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLT 383
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L +T IKESLR YP ++ R+ +D+K+ + + G C +++YG + + D
Sbjct: 384 QLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPD 443
Query: 170 ADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
+ + P R+ +PD A+ F G R CIG +F +
Sbjct: 444 SKVYNPYRF-DPDNPQQRSPLAYVPFSAGPRNCIGQSFAM 482
>BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 128 bits (309), Expect = 5e-29
Identities = 88/309 (28%), Positives = 163/309 (52%), Gaps = 11/309 (3%)
Query: 209 YTNEDENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNK 268
Y + + Y+SA+ E+ + +R R+ +DFIY ++ +R + +V+ + +
Sbjct: 218 YNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTE 277
Query: 269 IIARKRSELASGVAAA--NETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGF 324
+I +R L A A K +D++L ED L+D++IR E DT + G
Sbjct: 278 VIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGH 337
Query: 325 DTSSWILVYVLVNLGSFPEVQDRAYNEIMDVF-GDSDRDLEKEDLSKLVYTEAVLKETMR 383
DT+S + ++L NL +PE Q++ EI +V G +LE +DL++L +T +KE++R
Sbjct: 338 DTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLR 397
Query: 384 LYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERW--LD 439
Y + R ED+KL + + G C +S++G + + TVW D + P R+ +
Sbjct: 398 QYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVW-PDSKVYNPYRFDPDN 456
Query: 440 PQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGD-VSKLDFKFNFIIKP 498
PQ+ A+ FS G R+C G+++A+ +++ +A L ++++S D K+ K I++
Sbjct: 457 PQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRT 516
Query: 499 ISGSEIGLE 507
+G + +E
Sbjct: 517 ENGLWLKVE 525
Score = 97.1 bits (231), Expect = 1e-19
Identities = 54/160 (33%), Positives = 90/160 (56%), Gaps = 4/160 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVF-GDSERDVESDDLS 110
+I E +T +F G+DTTS ++++L NL Y + Q+K EEI+ V G ++E DDL+
Sbjct: 324 DIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLT 383
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L +T IKESLR YP ++ R+ +D+K+ + + G C +++YG + + D
Sbjct: 384 QLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPD 443
Query: 170 ADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
+ + P R+ +PD A+ F G R CIG +F +
Sbjct: 444 SKVYNPYRF-DPDNPQQRSPLAYVPFSAGPRNCIGQSFAM 482
>BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 128 bits (309), Expect = 5e-29
Identities = 88/309 (28%), Positives = 163/309 (52%), Gaps = 11/309 (3%)
Query: 209 YTNEDENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNK 268
Y + + Y+SA+ E+ + +R R+ +DFIY ++ +R + +V+ + +
Sbjct: 218 YNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTE 277
Query: 269 IIARKRSELASGVAAA--NETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGF 324
+I +R L A A K +D++L ED L+D++IR E DT + G
Sbjct: 278 VIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGH 337
Query: 325 DTSSWILVYVLVNLGSFPEVQDRAYNEIMDVF-GDSDRDLEKEDLSKLVYTEAVLKETMR 383
DT+S + ++L NL +PE Q++ EI +V G +LE +DL++L +T +KE++R
Sbjct: 338 DTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLR 397
Query: 384 LYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERW--LD 439
Y + R ED+KL + + G C +S++G + + TVW D + P R+ +
Sbjct: 398 QYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVW-PDSKVYNPYRFDPDN 456
Query: 440 PQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGD-VSKLDFKFNFIIKP 498
PQ+ A+ FS G R+C G+++A+ +++ +A L ++++S D K+ K I++
Sbjct: 457 PQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRT 516
Query: 499 ISGSEIGLE 507
+G + +E
Sbjct: 517 ENGLWLKVE 525
Score = 97.1 bits (231), Expect = 1e-19
Identities = 54/160 (33%), Positives = 90/160 (56%), Gaps = 4/160 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVF-GDSERDVESDDLS 110
+I E +T +F G+DTTS ++++L NL Y + Q+K EEI+ V G ++E DDL+
Sbjct: 324 DIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLT 383
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L +T IKESLR YP ++ R+ +D+K+ + + G C +++YG + + D
Sbjct: 384 QLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPD 443
Query: 170 ADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
+ + P R+ +PD A+ F G R CIG +F +
Sbjct: 444 SKVYNPYRF-DPDNPQQRSPLAYVPFSAGPRNCIGQSFAM 482
>AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens
cDNA FLJ39501 fis, clone PROST2016980, moderately
similar to CYTOCHROME P450 4F2 (EC 1.14.13.30). ).
Length = 531
Score = 128 bits (308), Expect = 6e-29
Identities = 88/309 (28%), Positives = 163/309 (52%), Gaps = 11/309 (3%)
Query: 209 YTNEDENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNK 268
Y + + Y+SA+ E+ + +R R+ +DFIY ++ +R + +V+ + +
Sbjct: 218 YNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTE 277
Query: 269 IIARKRSELASGVAAA--NETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGF 324
+I +R L A A K +D++L ED L+D++IR E DT + G
Sbjct: 278 VIQERRRALRRQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGH 337
Query: 325 DTSSWILVYVLVNLGSFPEVQDRAYNEIMDVF-GDSDRDLEKEDLSKLVYTEAVLKETMR 383
DT+S + ++L NL +PE Q++ EI +V G +LE +DL++L +T +KE++R
Sbjct: 338 DTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLR 397
Query: 384 LYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERW--LD 439
Y + R ED+KL + + G C +S++G + + TVW D + P R+ +
Sbjct: 398 QYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVW-PDSKVYNPYRFDPDN 456
Query: 440 PQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGD-VSKLDFKFNFIIKP 498
PQ+ A+ FS G R+C G+++A+ +++ +A L ++++S D K+ K I++
Sbjct: 457 PQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRT 516
Query: 499 ISGSEIGLE 507
+G + +E
Sbjct: 517 ENGLWLKVE 525
Score = 97.1 bits (231), Expect = 1e-19
Identities = 54/160 (33%), Positives = 90/160 (56%), Gaps = 4/160 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVF-GDSERDVESDDLS 110
+I E +T +F G+DTTS ++++L NL Y + Q+K EEI+ V G ++E DDL+
Sbjct: 324 DIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLT 383
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDD 169
+L +T IKESLR YP ++ R+ +D+K+ + + G C +++YG + + D
Sbjct: 384 QLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPD 443
Query: 170 ADKFRPERWLEPDGVPS-VYYAFATFGVGKRACIGTAFGV 208
+ + P R+ +PD A+ F G R CIG +F +
Sbjct: 444 SKVYNPYRF-DPDNPQQRSPLAYVPFSAGPRNCIGQSFAM 482
>BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein.
Length = 524
Score = 121 bits (292), Expect = 5e-27
Identities = 83/273 (30%), Positives = 149/273 (54%), Gaps = 13/273 (4%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ + KR ++ L DF+Y LT +R +V++ ++ +I +R L +
Sbjct: 221 YIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRRTLPT 280
Query: 280 -GVA--AANETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
G+ N+ +K +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSDR-DLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q++ E+ ++ D + ++E +DL++L + +KE++RL+ PV R
Sbjct: 341 LYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERWLDPQKIPDN---AF 448
+D L + + G C I++ GI+ + TVW D + P R+ + + I + AF
Sbjct: 401 CCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVW-PDPEVYDPFRF-NQENIKERSPLAF 458
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
FS G R+C G+A+A+ MK+ LA L ++I
Sbjct: 459 IPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491
Score = 91.1 bits (216), Expect = 9e-18
Identities = 54/159 (33%), Positives = 88/159 (55%), Gaps = 2/159 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSER-DVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E ++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQD-VKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+L + IKESLRL+P P+I R QD V + + G C IN+ GI+ + D
Sbjct: 377 QLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPD 436
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ + P R+ + + AF F G R CIG AF +
Sbjct: 437 PEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIGQAFAM 475
>AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein.
Length = 524
Score = 121 bits (292), Expect = 5e-27
Identities = 83/273 (30%), Positives = 149/273 (54%), Gaps = 13/273 (4%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ + KR ++ L DF+Y LT +R +V++ ++ +I +R L +
Sbjct: 221 YIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRRTLPT 280
Query: 280 -GVA--AANETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
G+ N+ +K +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSDR-DLEKEDLSKLVYTEAVLKETMRLYTMGPVSLR 393
L +L PE Q++ E+ ++ D + ++E +DL++L + +KE++RL+ PV R
Sbjct: 341 LYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISR 400
Query: 394 HIEEDVKLKN-FTLKAGTDCSISLFGINRH-TVWGEDVNEFKPERWLDPQKIPDN---AF 448
+D L + + G C I++ GI+ + TVW D + P R+ + + I + AF
Sbjct: 401 CCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVW-PDPEVYDPFRF-NQENIKERSPLAF 458
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
FS G R+C G+A+A+ MK+ LA L ++I
Sbjct: 459 IPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491
Score = 91.1 bits (216), Expect = 9e-18
Identities = 54/159 (33%), Positives = 88/159 (55%), Gaps = 2/159 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSER-DVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E ++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLA 376
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQD-VKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+L + IKESLRL+P P+I R QD V + + G C IN+ GI+ + D
Sbjct: 377 QLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPD 436
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ + P R+ + + AF F G R CIG AF +
Sbjct: 437 PEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIGQAFAM 475
>AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 118 bits (284), Expect = 5e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 210 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 270 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTGGISWFLY 329
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 330 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 503
Score = 91.1 bits (216), Expect = 9e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 304 DLRAEVDTFMFEGHDTTTGGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 362
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 363 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 422
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 423 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 460
>X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for
cytochrome P-450HP. ).
Length = 511
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 210 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 270 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 329
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 330 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 304 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 362
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 363 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 422
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 423 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 460
>J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung
cytochrome P450 (IV subfamily) BI protein, complete cds.
).
Length = 511
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 210 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 270 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 329
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 330 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 304 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 362
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 363 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 422
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 423 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 460
>DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 210 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 270 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 329
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 330 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 304 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 362
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 363 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 422
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 423 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 460
>BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 211 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 270
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 271 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 330
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 331 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 389
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 390 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 449
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 450 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 504
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 305 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 363
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 364 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 423
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 424 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 461
>AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P450
4B1 variant protein.
Length = 497
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 196 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 255
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 256 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 315
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 316 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 374
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 375 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 434
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 435 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 489
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 290 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 348
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 349 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 408
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 409 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 446
>AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P450
4B1 protein.
Length = 512
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 211 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 270
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 271 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 330
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 331 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 389
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 390 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 449
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 450 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 504
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 305 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 363
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 364 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 423
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 424 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 461
>AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 210 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 270 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 329
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 330 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 304 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 362
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 363 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 422
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 423 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 460
>AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 196 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 255
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 256 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 315
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 316 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 374
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 375 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 434
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 435 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 489
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 290 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 348
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 349 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 408
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 409 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 446
>AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 211 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 270
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 271 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 330
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 331 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 389
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 390 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 449
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 450 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 504
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 305 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 363
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 364 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 423
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 424 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 461
>AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 210 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 270 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 329
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 330 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 304 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 362
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 363 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 422
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 423 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 460
>AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 210 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 270 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 329
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 330 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 304 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 362
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 363 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 422
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 423 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 460
>AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 211 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 270
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 271 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 330
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 331 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 389
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 390 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 449
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 450 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 504
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 305 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 363
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 364 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 423
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 424 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 461
>AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 196 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 255
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 256 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 315
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 316 CMALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 374
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 375 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 434
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 435 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 489
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 290 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF-FQWDDLGK 348
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 349 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 408
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 409 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 446
>AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 118 bits (283), Expect = 6e-26
Identities = 78/295 (26%), Positives = 149/295 (50%), Gaps = 7/295 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y AV ++ ++ +R DFIY LT +R ++ ++ ++++I +++ L
Sbjct: 210 SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKED--ALTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ ++ LD++L ED L+D ++R EVDT + G DT++ + + L
Sbjct: 270 DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY 329
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
+ +PE Q R E+ ++ GD D + +DL K+ Y +KE+ RLY P R +
Sbjct: 330 CIALYPEHQHRCREEVREILGDQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388
Query: 397 EDVK-LKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ V + +L AG+ S+ ++ ++R++ D F R+ + K AF FS
Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGLE 507
G R+C G+ +A++ MK+ A L +++ S D S+L K +++ +G + L+
Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLK 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 48/158 (30%), Positives = 87/158 (55%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ +++ L + Y + Q + EE++ + GD + + DDL K
Sbjct: 304 DLRAEVDTFMFEGHDTTTSGISWFLYCIALYPEHQHRCREEVREILGDQDF-FQWDDLGK 362
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVK-INNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ Y IKES RLYP P ++R+L + V ++ +L AG ++++Y ++R++ D
Sbjct: 363 MTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDP 422
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F R+ + +AF F G R CIG F +
Sbjct: 423 EVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAM 460
>S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 519
Score = 109 bits (263), Expect = 2e-23
Identities = 71/298 (23%), Positives = 148/298 (49%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D +++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRL 506
Score = 82.6 bits (195), Expect = 3e-15
Identities = 50/158 (31%), Positives = 84/158 (53%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPSRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 591
Score = 109 bits (261), Expect = 3e-23
Identities = 68/279 (24%), Positives = 141/279 (50%), Gaps = 5/279 (1%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKL 488
FS G R+C G+ +A+ +K+ A L ++++ D +++
Sbjct: 449 PFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRI 487
Score = 82.6 bits (195), Expect = 3e-15
Identities = 50/158 (31%), Positives = 84/158 (53%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPSRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein.
Length = 519
Score = 108 bits (260), Expect = 4e-23
Identities = 71/298 (23%), Positives = 148/298 (49%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D +++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRL 506
Score = 81.4 bits (192), Expect = 7e-15
Identities = 50/158 (31%), Positives = 84/158 (53%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPFRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>D26481-1|BAA05491.1| 519|Homo sapiens fatty acids
omega-hydroxylase protein.
Length = 519
Score = 108 bits (260), Expect = 4e-23
Identities = 71/298 (23%), Positives = 148/298 (49%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D +++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRL 506
Score = 81.4 bits (192), Expect = 7e-15
Identities = 50/158 (31%), Positives = 84/158 (53%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPFRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 108 bits (260), Expect = 4e-23
Identities = 71/298 (23%), Positives = 148/298 (49%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D +++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRL 506
Score = 81.4 bits (192), Expect = 7e-15
Identities = 50/158 (31%), Positives = 84/158 (53%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPFRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22
protein.
Length = 519
Score = 108 bits (260), Expect = 4e-23
Identities = 70/298 (23%), Positives = 150/298 (50%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ +++ R + + D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLSSLVFCRMRNAFHENDAIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L + ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQTEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D +++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRL 506
Score = 82.2 bits (194), Expect = 4e-15
Identities = 50/158 (31%), Positives = 83/158 (52%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI + GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPSRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 108 bits (260), Expect = 4e-23
Identities = 71/298 (23%), Positives = 148/298 (49%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D +++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRL 506
Score = 81.4 bits (192), Expect = 7e-15
Identities = 50/158 (31%), Positives = 84/158 (53%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPFRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K
protein.
Length = 519
Score = 107 bits (257), Expect = 9e-23
Identities = 71/298 (23%), Positives = 147/298 (49%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D ++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRTPIPMARLVLKSKNGIHLRL 506
Score = 81.4 bits (192), Expect = 7e-15
Identities = 50/158 (31%), Positives = 84/158 (53%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPFRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfamily
IVA, polypeptide 11 protein.
Length = 519
Score = 107 bits (256), Expect = 1e-22
Identities = 70/298 (23%), Positives = 148/298 (49%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RL+ P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLFPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D +++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRL 506
Score = 79.8 bits (188), Expect = 2e-14
Identities = 49/158 (31%), Positives = 84/158 (53%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRL+P P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLFPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPFRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 519
Score = 105 bits (253), Expect = 3e-22
Identities = 69/298 (23%), Positives = 149/298 (50%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ +++ + + D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + ++ F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D +++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRL 506
Score = 82.2 bits (194), Expect = 4e-15
Identities = 50/158 (31%), Positives = 83/158 (52%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI + GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNL 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPSRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid
omega-hydroxylase CYP4A11 protein.
Length = 519
Score = 105 bits (253), Expect = 3e-22
Identities = 69/298 (23%), Positives = 149/298 (50%), Gaps = 6/298 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ +++ + + D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + ++ F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFL 448
Query: 450 AFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ A L ++++ D +++ ++K +G + L
Sbjct: 449 PFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRL 506
Score = 82.2 bits (194), Expect = 4e-15
Identities = 50/158 (31%), Positives = 83/158 (52%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI + GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNL 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 429 EVFDPSRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 464
>AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein.
Length = 505
Score = 104 bits (249), Expect = 9e-22
Identities = 70/274 (25%), Positives = 139/274 (50%), Gaps = 7/274 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y+ AV + I +R D ++ +S + + + +++ + K+I ++ L
Sbjct: 210 SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLK 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ + T + LD++L E+ ++ +++ EV T + AG DT+S + ++L
Sbjct: 270 DKLKQ-DTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILY 328
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
L +PE Q R +EI ++ GD + E LS++ YT +KE +RLY R ++
Sbjct: 329 CLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLD 387
Query: 397 EDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ + + +L AG I+++ ++ + + ED F P R+ + +KI AF FS
Sbjct: 388 KPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSA 447
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK 487
G R+C G+ +A+ K+ +A L ++K++ D S+
Sbjct: 448 GLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSR 481
Score = 89.8 bits (213), Expect = 2e-17
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E+ T +F G+DTTS ++++L L Y + QQ+ +EI+ + GD + + LS+
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQ 361
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE LRLY I R LD+ + + +L AG IN++ ++ + + +D
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + YAF F G R CIG F +
Sbjct: 422 QVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAI 459
>AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein.
Length = 505
Score = 104 bits (249), Expect = 9e-22
Identities = 70/274 (25%), Positives = 139/274 (50%), Gaps = 7/274 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y+ AV + I +R D ++ +S + + + +++ + K+I ++ L
Sbjct: 210 SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLK 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ + T + LD++L E+ ++ +++ EV T + AG DT+S + ++L
Sbjct: 270 DKLKQ-DTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILY 328
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
L +PE Q R +EI ++ GD + E LS++ YT +KE +RLY R ++
Sbjct: 329 CLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLD 387
Query: 397 EDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ + + +L AG I+++ ++ + + ED F P R+ + +KI AF FS
Sbjct: 388 KPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSA 447
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK 487
G R+C G+ +A+ K+ +A L ++K++ D S+
Sbjct: 448 GLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSR 481
Score = 89.8 bits (213), Expect = 2e-17
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E+ T +F G+DTTS ++++L L Y + QQ+ +EI+ + GD + + LS+
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQ 361
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE LRLY I R LD+ + + +L AG IN++ ++ + + +D
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + YAF F G R CIG F +
Sbjct: 422 QVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAI 459
>AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 104 bits (249), Expect = 9e-22
Identities = 70/274 (25%), Positives = 139/274 (50%), Gaps = 7/274 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y+ AV + I +R D ++ +S + + + +++ + K+I ++ L
Sbjct: 210 SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLK 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ + T + LD++L E+ ++ +++ EV T + AG DT+S + ++L
Sbjct: 270 DKLKQ-DTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILY 328
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
L +PE Q R +EI ++ GD + E LS++ YT +KE +RLY R ++
Sbjct: 329 CLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLD 387
Query: 397 EDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ + + +L AG I+++ ++ + + ED F P R+ + +KI AF FS
Sbjct: 388 KPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSA 447
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK 487
G R+C G+ +A+ K+ +A L ++K++ D S+
Sbjct: 448 GLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSR 481
Score = 89.8 bits (213), Expect = 2e-17
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E+ T +F G+DTTS ++++L L Y + QQ+ +EI+ + GD + + LS+
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQ 361
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE LRLY I R LD+ + + +L AG IN++ ++ + + +D
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + YAF F G R CIG F +
Sbjct: 422 QVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAI 459
>AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 104 bits (249), Expect = 9e-22
Identities = 70/274 (25%), Positives = 139/274 (50%), Gaps = 7/274 (2%)
Query: 219 AYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELA 278
+Y+ AV + I +R D ++ +S + + + +++ + K+I ++ L
Sbjct: 210 SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLK 269
Query: 279 SGVAAANETDNKYQGLLDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYVLV 336
+ + T + LD++L E+ ++ +++ EV T + AG DT+S + ++L
Sbjct: 270 DKLKQ-DTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILY 328
Query: 337 NLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIE 396
L +PE Q R +EI ++ GD + E LS++ YT +KE +RLY R ++
Sbjct: 329 CLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLD 387
Query: 397 EDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL--DPQKIPDNAFAAFSI 453
+ + + +L AG I+++ ++ + + ED F P R+ + +KI AF FS
Sbjct: 388 KPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSA 447
Query: 454 GKRSCTGRAYALTLMKINLAHLLRKYKISGDVSK 487
G R+C G+ +A+ K+ +A L ++K++ D S+
Sbjct: 448 GLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSR 481
Score = 89.8 bits (213), Expect = 2e-17
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E+ T +F G+DTTS ++++L L Y + QQ+ +EI+ + GD + + LS+
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQ 361
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE LRLY I R LD+ + + +L AG IN++ ++ + + +D
Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDP 421
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
F P R+ + YAF F G R CIG F +
Sbjct: 422 QVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAI 459
>AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43.3
protein.
Length = 503
Score = 101 bits (241), Expect = 8e-21
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V + + V D L +
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLAN-KAPVTYDALVQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFAL 449
Score = 71.7 bits (168), Expect = 6e-12
Identities = 43/176 (24%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI V + +
Sbjct: 289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLANK-APVTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 348 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +ALT +K+ + L+ +
Sbjct: 408 WTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 521
Score = 100 bits (240), Expect = 1e-20
Identities = 72/300 (24%), Positives = 147/300 (49%), Gaps = 8/300 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSN-KIIA 271
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ + K+I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLSHQHTRPKVIQ 269
Query: 272 RKRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSW 329
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 LRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTAS 329
Query: 330 ILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGP 389
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 GISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVP 388
Query: 390 VSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAF 448
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 GIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAF 448
Query: 449 AAFSIGKRSCTGRAYALTLMKINLAHL-LRKYKISGDVSKLDFKF-NFIIKPISGSEIGL 506
FS G R+C G+ +A+ +K+ L L ++++ D +++ ++K +G + L
Sbjct: 449 LPFSGGSRNCIGKQFAMNELKVGQQALTLVRFELLPDPTRIPIPIARLVLKSKNGIHLRL 508
Score = 81.4 bits (192), Expect = 7e-15
Identities = 50/158 (31%), Positives = 84/158 (53%), Gaps = 4/158 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 311 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 369
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 370 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 429
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ F P R+ G +AF F G R CIG F +
Sbjct: 430 EVFDPFRF--APGSAQHSHAFLPFSGGSRNCIGKQFAM 465
>BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein.
Length = 393
Score = 100 bits (240), Expect = 1e-20
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 184 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 242
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 243 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 302
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 303 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFAL 339
Score = 71.7 bits (168), Expect = 6e-12
Identities = 43/176 (24%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 179 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 237
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 238 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 297
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +ALT +K+ + L+ +
Sbjct: 298 WTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 353
>AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43.1
protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFAL 449
Score = 71.7 bits (168), Expect = 6e-12
Identities = 43/176 (24%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 348 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +ALT +K+ + L+ +
Sbjct: 408 WTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFAL 449
Score = 71.7 bits (168), Expect = 6e-12
Identities = 43/176 (24%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 348 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +ALT +K+ + L+ +
Sbjct: 408 WTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43
protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFAL 449
Score = 71.7 bits (168), Expect = 6e-12
Identities = 43/176 (24%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 348 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +ALT +K+ + L+ +
Sbjct: 408 WTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFAL 449
Score = 71.7 bits (168), Expect = 6e-12
Identities = 43/176 (24%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 348 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +ALT +K+ + L+ +
Sbjct: 408 WTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein.
Length = 503
Score = 100 bits (240), Expect = 1e-20
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFAL 449
Score = 71.7 bits (168), Expect = 6e-12
Identities = 43/176 (24%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 348 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +ALT +K+ + L+ +
Sbjct: 408 WTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 463
>L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3
24-hydroxylase protein.
Length = 513
Score = 97.9 bits (233), Expect = 7e-20
Identities = 59/187 (31%), Positives = 98/187 (52%), Gaps = 2/187 (1%)
Query: 296 DLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDV 355
D + + ++ L+ +E+ V +A +T++ L+++L NL P+VQ + EI V
Sbjct: 299 DFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSV 358
Query: 356 FGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSIS 415
++ R E EDL + Y +A LKE+MRL P + R +++ L + L GT ++
Sbjct: 359 LPENQRPRE-EDLRNMPYLKACLKESMRLTPGVPFTTRTLDKATVLGEYALPKGTVLMLN 417
Query: 416 LFGINRHTVWGEDVNEFKPERWL-DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAH 474
+ ED ++F+PERWL + +KI A F +GKR C GR A + + L
Sbjct: 418 TQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCW 477
Query: 475 LLRKYKI 481
++RKY I
Sbjct: 478 IVRKYDI 484
Score = 91.9 bits (218), Expect = 5e-18
Identities = 51/138 (36%), Positives = 78/138 (56%), Gaps = 2/138 (1%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
+TT+ +L ++L NL VQQK+ +EI++V +++R E +DL + Y +A +KES+RL
Sbjct: 328 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQRPRE-EDLRNMPYLKACLKESMRL 386
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P P R LD+ + Y L G +N + +D+ +FRPERWL+
Sbjct: 387 TPGVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI 446
Query: 186 SVYYAFATFGVGKRACIG 203
+ +A FGVGKR CIG
Sbjct: 447 NP-FAHLPFGVGKRMCIG 463
>AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 504
Score = 97.9 bits (233), Expect = 7e-20
Identities = 50/158 (31%), Positives = 83/158 (52%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSV-YYAFATFGVGKRACIGTAFGV 208
KF PE S+ Y + FG G R CIG F +
Sbjct: 413 KFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFAL 450
Score = 67.3 bits (157), Expect = 1e-10
Identities = 43/177 (24%), Positives = 87/177 (49%), Gaps = 4/177 (2%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 348 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 407
Query: 426 GEDVNEFKPE-RWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PE R+ K I + F G R+C G +ALT +K+ + L+ +
Sbjct: 408 WTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 464
>AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein.
Length = 504
Score = 97.9 bits (233), Expect = 7e-20
Identities = 50/158 (31%), Positives = 83/158 (52%), Gaps = 2/158 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSV-YYAFATFGVGKRACIGTAFGV 208
KF PE S+ Y + FG G R CIG F +
Sbjct: 413 KFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFAL 450
Score = 67.3 bits (157), Expect = 1e-10
Identities = 43/177 (24%), Positives = 87/177 (49%), Gaps = 4/177 (2%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 348 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 407
Query: 426 GEDVNEFKPE-RWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PE R+ K I + F G R+C G +ALT +K+ + L+ +
Sbjct: 408 WTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 464
>M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrome
P-450 nifedipine oxidase mRNA, complet cds. ).
Length = 503
Score = 95.9 bits (228), Expect = 3e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYTYTPFGSGPRNCIGMRFAL 449
Score = 74.9 bits (176), Expect = 6e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipine
oxidase protein.
Length = 502
Score = 95.9 bits (228), Expect = 3e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 293 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 351
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 352 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPE 411
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 412 KFLPERFSKKNKDNIDPYTYTPFGSGPRNCIGMRFAL 448
Score = 74.9 bits (176), Expect = 6e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 288 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 346
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 347 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKY 406
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 407 WTEPEKFLPERFSKKNKDNIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 462
>X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (cyp3 locus). ).
Length = 503
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 74.5 bits (175), Expect = 8e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA
encoding nifedipine oxidase, complete cds. ).
Length = 503
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver
glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
complete cds. ).
Length = 504
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 295 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 353
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 354 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPE 413
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 414 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 450
Score = 74.5 bits (175), Expect = 8e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 290 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 348
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 349 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKY 408
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 409 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 464
>D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein.
Length = 504
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 295 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 353
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 354 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPE 413
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 414 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 450
Score = 74.5 bits (175), Expect = 8e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 290 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 348
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 349 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKY 408
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 409 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 464
>DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family 3
subfamily A polypeptide 4 protein.
Length = 503
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfamily
IIIA, polypeptide 4 protein.
Length = 503
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein.
Length = 353
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 144 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 202
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 203 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 262
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 263 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 299
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 139 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 197
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 198 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 257
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 258 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 313
>AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein.
Length = 430
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 221 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 279
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 280 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 339
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 340 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 376
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 216 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 274
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 275 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 334
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 335 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 390
>AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein.
Length = 503
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450
polypeptide 4 protein.
Length = 503
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4
protein.
Length = 503
Score = 95.5 bits (227), Expect = 4e-19
Identities = 52/157 (33%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 75.4 bits (177), Expect = 5e-13
Identities = 46/176 (26%), Positives = 88/176 (50%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family
46, subfamily A, polypeptide 1 protein.
Length = 500
Score = 94.7 bits (225), Expect = 7e-19
Identities = 66/222 (29%), Positives = 110/222 (49%), Gaps = 9/222 (4%)
Query: 257 ELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKEDALTDQEIREEV 316
E IR + ++ + R+R L G + +L +LK A+E A D+ + +
Sbjct: 245 ESIRFLRQVGRDWVQRRREALKRGEEVPAD-------ILTQILK-AEEGAQDDEGLLDNF 296
Query: 317 DTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEA 376
T +AG +TS+ L + ++ L PE+ R E+ +V G S R L+ EDL +L Y
Sbjct: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDFEDLGRLQYLSQ 355
Query: 377 VLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPER 436
VLKE++RLY + R +EE+ + + T S + + R + ED F P+R
Sbjct: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415
Query: 437 WLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRK 478
+ P + FS+G RSC G+ +A +K+ +A LL++
Sbjct: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457
Score = 80.6 bits (190), Expect = 1e-14
Identities = 45/154 (29%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
+L+ T G++T++ L + +M L ++ ++ E+ V G S+R ++ +DL +L
Sbjct: 292 LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDFEDLGRL 350
Query: 113 VYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADK 172
Y V+KESLRLYP A FR L+++ I+ + + Y + R + +D
Sbjct: 351 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 410
Query: 173 FRPERWLEPDGVPSVYYAFATFGVGKRACIGTAF 206
F P+R+ G P + + F +G R+CIG F
Sbjct: 411 FNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQF 442
>AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxylase
protein.
Length = 500
Score = 94.7 bits (225), Expect = 7e-19
Identities = 66/222 (29%), Positives = 110/222 (49%), Gaps = 9/222 (4%)
Query: 257 ELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKEDALTDQEIREEV 316
E IR + ++ + R+R L G + +L +LK A+E A D+ + +
Sbjct: 245 ESIRFLRQVGRDWVQRRREALKRGEEVPAD-------ILTQILK-AEEGAQDDEGLLDNF 296
Query: 317 DTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEA 376
T +AG +TS+ L + ++ L PE+ R E+ +V G S R L+ EDL +L Y
Sbjct: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDFEDLGRLQYLSQ 355
Query: 377 VLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPER 436
VLKE++RLY + R +EE+ + + T S + + R + ED F P+R
Sbjct: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415
Query: 437 WLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRK 478
+ P + FS+G RSC G+ +A +K+ +A LL++
Sbjct: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457
Score = 80.6 bits (190), Expect = 1e-14
Identities = 45/154 (29%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
+L+ T G++T++ L + +M L ++ ++ E+ V G S+R ++ +DL +L
Sbjct: 292 LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDFEDLGRL 350
Query: 113 VYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADK 172
Y V+KESLRLYP A FR L+++ I+ + + Y + R + +D
Sbjct: 351 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 410
Query: 173 FRPERWLEPDGVPSVYYAFATFGVGKRACIGTAF 206
F P+R+ G P + + F +G R+CIG F
Sbjct: 411 FNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQF 442
>S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D
24-hydroxylase cytochrome P450 subunit protein.
Length = 257
Score = 93.9 bits (223), Expect = 1e-18
Identities = 57/187 (30%), Positives = 96/187 (51%), Gaps = 2/187 (1%)
Query: 296 DLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDV 355
D + + ++ L+ +E+ V +A +T++ L+++L NL P+VQ + EI V
Sbjct: 43 DFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSV 102
Query: 356 FGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSIS 415
++ EDL + Y +A LKE+MRL P + R +++ L + L GT ++
Sbjct: 103 LPENQVP-RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLN 161
Query: 416 LFGINRHTVWGEDVNEFKPERWL-DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAH 474
+ ED ++F+PERWL + +KI A F +GKR C GR A + + L
Sbjct: 162 TQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCW 221
Query: 475 LLRKYKI 481
++RKY I
Sbjct: 222 IVRKYDI 228
Score = 89.0 bits (211), Expect = 3e-17
Identities = 49/138 (35%), Positives = 77/138 (55%), Gaps = 2/138 (1%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
+TT+ +L ++L NL VQQK+ +EI++V +++ ++DL + Y +A +KES+RL
Sbjct: 72 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVP-RAEDLRNMPYLKACLKESMRL 130
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P P R LD+ + Y L G +N + +D+ +FRPERWL+
Sbjct: 131 TPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI 190
Query: 186 SVYYAFATFGVGKRACIG 203
+ +A FGVGKR CIG
Sbjct: 191 NP-FAHLPFGVGKRMCIG 207
>AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylase
splice variant protein.
Length = 372
Score = 93.9 bits (223), Expect = 1e-18
Identities = 57/187 (30%), Positives = 96/187 (51%), Gaps = 2/187 (1%)
Query: 296 DLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDV 355
D + + ++ L+ +E+ V +A +T++ L+++L NL P+VQ + EI V
Sbjct: 158 DFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSV 217
Query: 356 FGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSIS 415
++ EDL + Y +A LKE+MRL P + R +++ L + L GT ++
Sbjct: 218 LPENQVP-RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLN 276
Query: 416 LFGINRHTVWGEDVNEFKPERWL-DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAH 474
+ ED ++F+PERWL + +KI A F +GKR C GR A + + L
Sbjct: 277 TQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCW 336
Query: 475 LLRKYKI 481
++RKY I
Sbjct: 337 IVRKYDI 343
Score = 89.0 bits (211), Expect = 3e-17
Identities = 49/138 (35%), Positives = 77/138 (55%), Gaps = 2/138 (1%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
+TT+ +L ++L NL VQQK+ +EI++V +++ ++DL + Y +A +KES+RL
Sbjct: 187 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVP-RAEDLRNMPYLKACLKESMRL 245
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P P R LD+ + Y L G +N + +D+ +FRPERWL+
Sbjct: 246 TPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI 305
Query: 186 SVYYAFATFGVGKRACIG 203
+ +A FGVGKR CIG
Sbjct: 306 NP-FAHLPFGVGKRMCIG 322
>AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 514
Score = 93.9 bits (223), Expect = 1e-18
Identities = 57/187 (30%), Positives = 96/187 (51%), Gaps = 2/187 (1%)
Query: 296 DLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDV 355
D + + ++ L+ +E+ V +A +T++ L+++L NL P+VQ + EI V
Sbjct: 300 DFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSV 359
Query: 356 FGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSIS 415
++ EDL + Y +A LKE+MRL P + R +++ L + L GT ++
Sbjct: 360 LPENQVP-RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLN 418
Query: 416 LFGINRHTVWGEDVNEFKPERWL-DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAH 474
+ ED ++F+PERWL + +KI A F +GKR C GR A + + L
Sbjct: 419 TQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCW 478
Query: 475 LLRKYKI 481
++RKY I
Sbjct: 479 IVRKYDI 485
Score = 89.0 bits (211), Expect = 3e-17
Identities = 49/138 (35%), Positives = 77/138 (55%), Gaps = 2/138 (1%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
+TT+ +L ++L NL VQQK+ +EI++V +++ ++DL + Y +A +KES+RL
Sbjct: 329 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVP-RAEDLRNMPYLKACLKESMRL 387
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P P R LD+ + Y L G +N + +D+ +FRPERWL+
Sbjct: 388 TPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI 447
Query: 186 SVYYAFATFGVGKRACIG 203
+ +A FGVGKR CIG
Sbjct: 448 NP-FAHLPFGVGKRMCIG 464
>AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 372
Score = 93.9 bits (223), Expect = 1e-18
Identities = 57/187 (30%), Positives = 96/187 (51%), Gaps = 2/187 (1%)
Query: 296 DLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDV 355
D + + ++ L+ +E+ V +A +T++ L+++L NL P+VQ + EI V
Sbjct: 158 DFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSV 217
Query: 356 FGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSIS 415
++ EDL + Y +A LKE+MRL P + R +++ L + L GT ++
Sbjct: 218 LPENQVP-RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLN 276
Query: 416 LFGINRHTVWGEDVNEFKPERWL-DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAH 474
+ ED ++F+PERWL + +KI A F +GKR C GR A + + L
Sbjct: 277 TQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCW 336
Query: 475 LLRKYKI 481
++RKY I
Sbjct: 337 IVRKYDI 343
Score = 89.0 bits (211), Expect = 3e-17
Identities = 49/138 (35%), Positives = 77/138 (55%), Gaps = 2/138 (1%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
+TT+ +L ++L NL VQQK+ +EI++V +++ ++DL + Y +A +KES+RL
Sbjct: 187 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVP-RAEDLRNMPYLKACLKESMRL 245
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P P R LD+ + Y L G +N + +D+ +FRPERWL+
Sbjct: 246 TPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI 305
Query: 186 SVYYAFATFGVGKRACIG 203
+ +A FGVGKR CIG
Sbjct: 306 NP-FAHLPFGVGKRMCIG 322
>X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase
protein.
Length = 530
Score = 93.1 bits (221), Expect = 2e-18
Identities = 65/247 (26%), Positives = 118/247 (47%), Gaps = 10/247 (4%)
Query: 268 KIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTS 327
K+I K ++ + + AA + G L +L + L+ +E + +MAG DT+
Sbjct: 283 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQ---LSPREAMGSLPELLMAGVDTT 339
Query: 328 SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTM 387
S L + L +L PE+Q+ + E++ V + + + +D + + +AVLKET+RLY +
Sbjct: 340 SNTLTWALYHLSKDPEIQEALHEEVVGVV-PAGQVPQHKDFAHMPLLKAVLKETLRLYPV 398
Query: 388 GPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL------DPQ 441
P + R IE+++++ F T + ++R + F+P RWL P+
Sbjct: 399 VPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPR 458
Query: 442 KIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISG 501
F G R+C GR A M++ LA L++KYK+ + K I +
Sbjct: 459 IQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPN 518
Query: 502 SEIGLEY 508
++GL++
Sbjct: 519 KKVGLQF 525
Score = 81.0 bits (191), Expect = 9e-15
Identities = 44/156 (28%), Positives = 80/156 (51%), Gaps = 5/156 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E + L + G DTTS TLT+ L +L ++Q+ ++EE+ V + + D +
Sbjct: 323 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVP-QHKDFAH 381
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ +AV+KE+LRLYP+ P R ++++++++ + Y ++R + +
Sbjct: 382 MPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPE 441
Query: 172 KFRPERWL--EPDGVPSVYYAFAT--FGVGKRACIG 203
F+P RWL P + + F + FG G RAC+G
Sbjct: 442 SFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLG 477
>M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase
protein.
Length = 531
Score = 93.1 bits (221), Expect = 2e-18
Identities = 65/247 (26%), Positives = 118/247 (47%), Gaps = 10/247 (4%)
Query: 268 KIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTS 327
K+I K ++ + + AA + G L +L + L+ +E + +MAG DT+
Sbjct: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQ---LSPREAMGSLPELLMAGVDTT 340
Query: 328 SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTM 387
S L + L +L PE+Q+ + E++ V + + + +D + + +AVLKET+RLY +
Sbjct: 341 SNTLTWALYHLSKDPEIQEALHEEVVGVV-PAGQVPQHKDFAHMPLLKAVLKETLRLYPV 399
Query: 388 GPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL------DPQ 441
P + R IE+++++ F T + ++R + F+P RWL P+
Sbjct: 400 VPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPR 459
Query: 442 KIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISG 501
F G R+C GR A M++ LA L++KYK+ + K I +
Sbjct: 460 IQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPN 519
Query: 502 SEIGLEY 508
++GL++
Sbjct: 520 KKVGLQF 526
Score = 81.0 bits (191), Expect = 9e-15
Identities = 44/156 (28%), Positives = 80/156 (51%), Gaps = 5/156 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E + L + G DTTS TLT+ L +L ++Q+ ++EE+ V + + D +
Sbjct: 324 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVP-QHKDFAH 382
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ +AV+KE+LRLYP+ P R ++++++++ + Y ++R + +
Sbjct: 383 MPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPE 442
Query: 172 KFRPERWL--EPDGVPSVYYAFAT--FGVGKRACIG 203
F+P RWL P + + F + FG G RAC+G
Sbjct: 443 SFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLG 478
>J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3
protein.
Length = 502
Score = 93.1 bits (221), Expect = 2e-18
Identities = 50/149 (33%), Positives = 82/149 (55%), Gaps = 4/149 (2%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIK 120
+F GY+TTS L++ L L T+ DVQQK+ +EI V ++ D + ++ Y + V+
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVN 361
Query: 121 ESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW-L 179
E+LRL+P+A + R +DV+IN + G I Y ++ + + ++FRPER+
Sbjct: 362 ETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421
Query: 180 EPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ D + Y + FG G R CIG F +
Sbjct: 422 KKDSIDP--YIYTPFGTGPRNCIGMRFAL 448
Score = 76.2 bits (179), Expect = 3e-13
Identities = 46/175 (26%), Positives = 88/175 (50%), Gaps = 2/175 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L + L L + P+VQ + EI D +
Sbjct: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G+ I + ++ +
Sbjct: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQ-KIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ EF+PER+ + I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462
>BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 93.1 bits (221), Expect = 2e-18
Identities = 65/247 (26%), Positives = 118/247 (47%), Gaps = 10/247 (4%)
Query: 268 KIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTS 327
K+I K ++ + + AA + G L +L + L+ +E + +MAG DT+
Sbjct: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQ---LSPREAMGSLPELLMAGVDTT 340
Query: 328 SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTM 387
S L + L +L PE+Q+ + E++ V + + + +D + + +AVLKET+RLY +
Sbjct: 341 SNTLTWALYHLSKDPEIQEALHEEVVGVV-PAGQVPQHKDFAHMPLLKAVLKETLRLYPV 399
Query: 388 GPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL------DPQ 441
P + R IE+++++ F T + ++R + F+P RWL P+
Sbjct: 400 VPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPR 459
Query: 442 KIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISG 501
F G R+C GR A M++ LA L++KYK+ + K I +
Sbjct: 460 IQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPN 519
Query: 502 SEIGLEY 508
++GL++
Sbjct: 520 KKVGLQF 526
Score = 81.0 bits (191), Expect = 9e-15
Identities = 44/156 (28%), Positives = 80/156 (51%), Gaps = 5/156 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E + L + G DTTS TLT+ L +L ++Q+ ++EE+ V + + D +
Sbjct: 324 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVP-QHKDFAH 382
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ +AV+KE+LRLYP+ P R ++++++++ + Y ++R + +
Sbjct: 383 MPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPE 442
Query: 172 KFRPERWL--EPDGVPSVYYAFAT--FGVGKRACIG 203
F+P RWL P + + F + FG G RAC+G
Sbjct: 443 SFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLG 478
>BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 93.1 bits (221), Expect = 2e-18
Identities = 65/247 (26%), Positives = 118/247 (47%), Gaps = 10/247 (4%)
Query: 268 KIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTS 327
K+I K ++ + + AA + G L +L + L+ +E + +MAG DT+
Sbjct: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQ---LSPREAMGSLPELLMAGVDTT 340
Query: 328 SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTM 387
S L + L +L PE+Q+ + E++ V + + + +D + + +AVLKET+RLY +
Sbjct: 341 SNTLTWALYHLSKDPEIQEALHEEVVGVV-PAGQVPQHKDFAHMPLLKAVLKETLRLYPV 399
Query: 388 GPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL------DPQ 441
P + R IE+++++ F T + ++R + F+P RWL P+
Sbjct: 400 VPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPR 459
Query: 442 KIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISG 501
F G R+C GR A M++ LA L++KYK+ + K I +
Sbjct: 460 IQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPN 519
Query: 502 SEIGLEY 508
++GL++
Sbjct: 520 KKVGLQF 526
Score = 81.0 bits (191), Expect = 9e-15
Identities = 44/156 (28%), Positives = 80/156 (51%), Gaps = 5/156 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E + L + G DTTS TLT+ L +L ++Q+ ++EE+ V + + D +
Sbjct: 324 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVP-QHKDFAH 382
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ +AV+KE+LRLYP+ P R ++++++++ + Y ++R + +
Sbjct: 383 MPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPE 442
Query: 172 KFRPERWL--EPDGVPSVYYAFAT--FGVGKRACIG 203
F+P RWL P + + F + FG G RAC+G
Sbjct: 443 SFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLG 478
>BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 protein.
Length = 502
Score = 93.1 bits (221), Expect = 2e-18
Identities = 50/149 (33%), Positives = 82/149 (55%), Gaps = 4/149 (2%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIK 120
+F GY+TTS L++ L L T+ DVQQK+ +EI V ++ D + ++ Y + V+
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVN 361
Query: 121 ESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW-L 179
E+LRL+P+A + R +DV+IN + G I Y ++ + + ++FRPER+
Sbjct: 362 ETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421
Query: 180 EPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ D + Y + FG G R CIG F +
Sbjct: 422 KKDSIDP--YIYTPFGTGPRNCIGMRFAL 448
Score = 76.2 bits (179), Expect = 3e-13
Identities = 46/175 (26%), Positives = 88/175 (50%), Gaps = 2/175 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L + L L + P+VQ + EI D +
Sbjct: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G+ I + ++ +
Sbjct: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQ-KIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ EF+PER+ + I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462
>AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein.
Length = 502
Score = 93.1 bits (221), Expect = 2e-18
Identities = 50/149 (33%), Positives = 82/149 (55%), Gaps = 4/149 (2%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIK 120
+F GY+TTS L++ L L T+ DVQQK+ +EI V ++ D + ++ Y + V+
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVN 361
Query: 121 ESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW-L 179
E+LRL+P+A + R +DV+IN + G I Y ++ + + ++FRPER+
Sbjct: 362 ETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421
Query: 180 EPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ D + Y + FG G R CIG F +
Sbjct: 422 KKDSIDP--YIYTPFGTGPRNCIGMRFAL 448
Score = 76.2 bits (179), Expect = 3e-13
Identities = 46/175 (26%), Positives = 88/175 (50%), Gaps = 2/175 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L + L L + P+VQ + EI D +
Sbjct: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G+ I + ++ +
Sbjct: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQ-KIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ EF+PER+ + I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462
>AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase
protein.
Length = 531
Score = 92.3 bits (219), Expect = 4e-18
Identities = 65/247 (26%), Positives = 117/247 (47%), Gaps = 10/247 (4%)
Query: 268 KIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTS 327
K+I K ++ + + AA + G L +L + L+ +E + +MAG DT+
Sbjct: 284 KLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQ---LSPREAMGSLPELLMAGVDTT 340
Query: 328 SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTM 387
S L + L +L PE+Q + E++ V + + + +D + + +AVLKET+RLY +
Sbjct: 341 SNTLTWALYHLSKDPEIQKALHEEVVGVV-PAGQVPQHKDFAHMPLLKAVLKETLRLYPV 399
Query: 388 GPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL------DPQ 441
P + R IE+++++ F T + ++R + F+P RWL P+
Sbjct: 400 VPTNSRIIEKEIEVDGFLFPKNTQFVFCHYEVSRDPTAFSEPESFQPHRWLRNSQPATPR 459
Query: 442 KIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISG 501
F G R+C GR A M++ LA L++KYK+ + K I +
Sbjct: 460 IQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPN 519
Query: 502 SEIGLEY 508
++GL++
Sbjct: 520 KKVGLQF 526
Score = 81.0 bits (191), Expect = 9e-15
Identities = 44/156 (28%), Positives = 80/156 (51%), Gaps = 5/156 (3%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E + L + G DTTS TLT+ L +L ++Q+ ++EE+ V + + D +
Sbjct: 324 EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQKALHEEVVGVVPAGQVP-QHKDFAH 382
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ +AV+KE+LRLYP+ P R ++++++++ + Y ++R + +
Sbjct: 383 MPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYEVSRDPTAFSEPE 442
Query: 172 KFRPERWL--EPDGVPSVYYAFAT--FGVGKRACIG 203
F+P RWL P + + F + FG G RAC+G
Sbjct: 443 SFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLG 478
>AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 variant protein.
Length = 502
Score = 92.3 bits (219), Expect = 4e-18
Identities = 50/149 (33%), Positives = 82/149 (55%), Gaps = 4/149 (2%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIK 120
+F GY+TTS L++ L L T+ DVQQK+ +EI V ++ D + ++ Y + V+
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVN 361
Query: 121 ESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW-L 179
E+LRL+P+A + R +DV+IN + G I Y ++ + + ++FRPER+
Sbjct: 362 ETLRLFPVAIRLERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421
Query: 180 EPDGVPSVYYAFATFGVGKRACIGTAFGV 208
+ D + Y + FG G R CIG F +
Sbjct: 422 KKDSIDP--YIYTPFGTGPRNCIGMRFAL 448
Score = 74.9 bits (176), Expect = 6e-13
Identities = 46/175 (26%), Positives = 87/175 (49%), Gaps = 2/175 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L + L L + P+VQ + EI D +
Sbjct: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R +DV++ + G+ I + ++ +
Sbjct: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQ-KIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ EF+PER+ + I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462
>D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa
protein.
Length = 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ +EI V ++ D + +
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L Y + V+ E+LRL+P+A + R +DV+IN + G I Y ++ + + +
Sbjct: 353 LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 74.9 bits (176), Expect = 6e-13
Identities = 46/176 (26%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEI-DTVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + +L Y + V+ ET+RL+ + R ++DV++ + G I + ++ +
Sbjct: 348 DTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 7 protein.
Length = 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ +EI V ++ D + +
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L Y + V+ E+LRL+P+A + R +DV+IN + G I Y ++ + + +
Sbjct: 353 LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 74.9 bits (176), Expect = 6e-13
Identities = 46/176 (26%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEI-DTVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + +L Y + V+ ET+RL+ + R ++DV++ + G I + ++ +
Sbjct: 348 DTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant
3A7 protein.
Length = 535
Score = 91.9 bits (218), Expect = 5e-18
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ +EI V ++ D + +
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L Y + V+ E+LRL+P+A + R +DV+IN + G I Y ++ + + +
Sbjct: 353 LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 74.9 bits (176), Expect = 6e-13
Identities = 46/176 (26%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEI-DTVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + +L Y + V+ ET+RL+ + R ++DV++ + G I + ++ +
Sbjct: 348 DTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450
polypeptide 7 protein.
Length = 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 50/157 (31%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F GY+TTS L++++ L T+ DVQQK+ +EI V ++ D + +
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L Y + V+ E+LRL+P+A + R +DV+IN + G I Y ++ + + +
Sbjct: 353 LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 74.9 bits (176), Expect = 6e-13
Identities = 46/176 (26%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG++T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEI-DTVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + +L Y + V+ ET+RL+ + R ++DV++ + G I + ++ +
Sbjct: 348 DTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
>AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4
protein.
Length = 503
Score = 91.9 bits (218), Expect = 5e-18
Identities = 51/157 (32%), Positives = 85/157 (54%), Gaps = 1/157 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F G +TTS L++++ L T+ DVQQK+ EEI V ++ D + +
Sbjct: 294 ELVAQSIIFIFAGCETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+PIA + R +DV+IN + G I Y ++R + + +
Sbjct: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIGTAFGV 208
KF PER+ + + Y + FG G R CIG F +
Sbjct: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
Score = 73.3 bits (172), Expect = 2e-12
Identities = 46/176 (26%), Positives = 87/176 (49%), Gaps = 3/176 (1%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I AG +T+S +L +++ L + P+VQ + EI D +
Sbjct: 289 ALSDLELVAQSIIFIFAGCETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ + ++ Y + V+ ET+RL+ + R ++DV++ + G I + ++R +
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407
Query: 426 GEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+ +F PER+ K I + F G R+C G +AL MK+ L +L+ +
Sbjct: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463
>D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV
protein.
Length = 389
Score = 90.2 bits (214), Expect = 1e-17
Identities = 54/169 (31%), Positives = 99/169 (58%), Gaps = 6/169 (3%)
Query: 220 YMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELAS 279
Y++A+ E+ ++TKR ++ L IDF+Y LT +R R+V++ ++ +I +R L S
Sbjct: 221 YIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPS 280
Query: 280 -GVAAANETDNKYQGL--LDLMLKLAKEDA--LTDQEIREEVDTAIMAGFDTSSWILVYV 334
GV + K + L +D++L ED L+D++IR E DT + G DT++ L +V
Sbjct: 281 QGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWV 340
Query: 335 LVNLGSFPEVQDRAYNEIMDVFGDSD-RDLEKEDLSKLVYTEAVLKETM 382
L +L PE Q+R E+ ++ D + +++E +DL++L + +KE++
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESL 389
Score = 53.6 bits (123), Expect = 2e-06
Identities = 26/73 (35%), Positives = 48/73 (65%), Gaps = 1/73 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSE-RDVESDDLS 110
+I E +T +F G+DTT+ L++VL +L + + Q++ +E++ + D E +++E DDL+
Sbjct: 317 DIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376
Query: 111 KLVYTEAVIKESL 123
+L + IKESL
Sbjct: 377 QLPFLTMCIKESL 389
>BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein.
Length = 455
Score = 90.2 bits (214), Expect = 1e-17
Identities = 61/247 (24%), Positives = 121/247 (48%), Gaps = 5/247 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFL 448
Query: 450 AFSIGKR 456
FS G R
Sbjct: 449 PFSGGSR 455
Score = 72.5 bits (170), Expect = 3e-12
Identities = 46/149 (30%), Positives = 79/149 (53%), Gaps = 4/149 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKR 199
+ F P R+ G +AF F G R
Sbjct: 429 EVFDPFRF--APGSAQHSHAFLPFSGGSR 455
>AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 455
Score = 90.2 bits (214), Expect = 1e-17
Identities = 61/247 (24%), Positives = 121/247 (48%), Gaps = 5/247 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ ++ R + Q D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + + F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFL 448
Query: 450 AFSIGKR 456
FS G R
Sbjct: 449 PFSGGSR 455
Score = 72.5 bits (170), Expect = 3e-12
Identities = 46/149 (30%), Positives = 79/149 (53%), Gaps = 4/149 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI ++ GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNP 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKR 199
+ F P R+ G +AF F G R
Sbjct: 429 EVFDPFRF--APGSAQHSHAFLPFSGGSR 455
>BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein.
Length = 372
Score = 88.2 bits (209), Expect = 6e-17
Identities = 58/188 (30%), Positives = 93/188 (49%), Gaps = 4/188 (2%)
Query: 297 LMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVF 356
L+ L ALT QEI V ++AG DT+S+ L + + L PEVQ Y EI+
Sbjct: 155 LLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYILARHPEVQQTVYREIVKNL 214
Query: 357 GDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISL 416
G+ D+ K+ A+LKET+RL+ + P + R +ED+ + + + GT ++
Sbjct: 215 GERHVP-TAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCH 273
Query: 417 FGINRHTVWGEDVNEFKPERWL---DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLA 473
+ + EF+PERWL D ++ + F G RSC GR A + + +
Sbjct: 274 YATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVI 333
Query: 474 HLLRKYKI 481
LL+ ++I
Sbjct: 334 QLLQHFEI 341
Score = 82.6 bits (195), Expect = 3e-15
Identities = 53/154 (34%), Positives = 78/154 (50%), Gaps = 4/154 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDV-ESDDLS 110
EI + + G DTTS TL++ + L + +VQQ +Y EI G ER V + D+
Sbjct: 169 EIYANVTEMLLAGVDTTSFTLSWTVYILARHPEVQQTVYREIVKNLG--ERHVPTAADVP 226
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDA 170
K+ A++KE+LRL+P+ P R +D+ I Y + G A+ Y + A
Sbjct: 227 KVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRA 286
Query: 171 DKFRPERWLEPDGVPSV-YYAFATFGVGKRACIG 203
+FRPERWL + V + FG G R+CIG
Sbjct: 287 KEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIG 320
>AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein.
Length = 372
Score = 88.2 bits (209), Expect = 6e-17
Identities = 58/188 (30%), Positives = 93/188 (49%), Gaps = 4/188 (2%)
Query: 297 LMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVF 356
L+ L ALT QEI V ++AG DT+S+ L + + L PEVQ Y EI+
Sbjct: 155 LLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNL 214
Query: 357 GDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISL 416
G+ D+ K+ A+LKET+RL+ + P + R +ED+ + + + GT ++
Sbjct: 215 GERHVP-TAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCH 273
Query: 417 FGINRHTVWGEDVNEFKPERWL---DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLA 473
+ + EF+PERWL D ++ + F G RSC GR A + + +
Sbjct: 274 YATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVI 333
Query: 474 HLLRKYKI 481
LL+ ++I
Sbjct: 334 QLLQHFEI 341
Score = 82.6 bits (195), Expect = 3e-15
Identities = 53/154 (34%), Positives = 78/154 (50%), Gaps = 4/154 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDV-ESDDLS 110
EI + + G DTTS TL++ + L + +VQQ +Y EI G ER V + D+
Sbjct: 169 EIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLG--ERHVPTAADVP 226
Query: 111 KLVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDA 170
K+ A++KE+LRL+P+ P R +D+ I Y + G A+ Y + A
Sbjct: 227 KVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRA 286
Query: 171 DKFRPERWLEPDGVPSV-YYAFATFGVGKRACIG 203
+FRPERWL + V + FG G R+CIG
Sbjct: 287 KEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIG 320
>AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 455
Score = 87.4 bits (207), Expect = 1e-16
Identities = 59/247 (23%), Positives = 122/247 (49%), Gaps = 5/247 (2%)
Query: 213 DENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNKIIAR 272
D N +++Y+ A+ ++ +++ + + D IY+LTS + ++ ++ ++++I
Sbjct: 211 DRN-SQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQL 269
Query: 273 KRSELASGVAAANETDNKYQGLLDLML--KLAKEDALTDQEIREEVDTAIMAGFDTSSWI 330
++++L ++ LD++L K+ L+D+++R EVDT + G DT++
Sbjct: 270 RKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASG 329
Query: 331 LVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPV 390
+ ++L L + P+ Q+R EI + GD + L ++ YT +KE +RLY P
Sbjct: 330 ISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPG 388
Query: 391 SLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAFA 449
R + V + +L G +S++G++ + ++ F P R+ +AF
Sbjct: 389 IGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFL 448
Query: 450 AFSIGKR 456
FS G R
Sbjct: 449 PFSGGSR 455
Score = 73.3 bits (172), Expect = 2e-12
Identities = 46/149 (30%), Positives = 78/149 (52%), Gaps = 4/149 (2%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
++ E++T +F G+DTT+ ++++L L T+ Q++ EEI + GD + + L +
Sbjct: 310 DLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQ 368
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDA 170
+ YT IKE+LRLYP P I REL V + +L G +++YG++ + +
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNL 428
Query: 171 DKFRPERWLEPDGVPSVYYAFATFGVGKR 199
+ F P R+ G +AF F G R
Sbjct: 429 EVFDPSRF--APGSAQHSHAFLPFSGGSR 455
>AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens
cDNA FLJ33567 fis, clone BRAMY2010272, highly similar to
Homo sapiens cholesterol 24-hydroxylase mRNA. ).
Length = 337
Score = 85.8 bits (203), Expect = 3e-16
Identities = 66/222 (29%), Positives = 109/222 (49%), Gaps = 19/222 (8%)
Query: 257 ELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLAKEDALTDQEIREEV 316
E IR + ++ + R+R L G + +L +LK A+E A D+ + +
Sbjct: 92 ESIRFLRQVGRDWVQRRREALKRGEEVPAD-------ILTQILK-AEEGAQDDEGLLDNF 143
Query: 317 DTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEA 376
T +AG +TS+ L + ++ L PE+ R E+ +V G S R L+ EDL +L Y
Sbjct: 144 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDFEDLGRLQYLSQ 202
Query: 377 VLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPER 436
VLKE++RLY + R +EE+ + F S + + R + ED F P+R
Sbjct: 203 VLKESLRLYPPAWGTFRLLEEETLIDGF----------STYVMGRMDTYFEDPLTFNPDR 252
Query: 437 WLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRK 478
+ P + FS+G RSC G+ +A +K+ +A LL++
Sbjct: 253 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 294
Score = 72.9 bits (171), Expect = 2e-12
Identities = 45/154 (29%), Positives = 79/154 (51%), Gaps = 13/154 (8%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
+L+ T G++T++ L + +M L ++ ++ E+ V G S+R ++ +DL +L
Sbjct: 139 LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYLDFEDLGRL 197
Query: 113 VYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADK 172
Y V+KESLRLYP A FR L+++ I+ + + Y + R + +D
Sbjct: 198 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGF----------STYVMGRMDTYFEDPLT 247
Query: 173 FRPERWLEPDGVPSVYYAFATFGVGKRACIGTAF 206
F P+R+ G P + + F +G R+CIG F
Sbjct: 248 FNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQF 279
>BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein.
Length = 280
Score = 85.0 bits (201), Expect = 6e-16
Identities = 41/126 (32%), Positives = 71/126 (56%), Gaps = 1/126 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 154 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 212
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 213 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 272
Query: 172 KFRPER 177
KF PER
Sbjct: 273 KFCPER 278
Score = 55.6 bits (128), Expect = 4e-07
Identities = 31/131 (23%), Positives = 66/131 (50%), Gaps = 1/131 (0%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 149 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 207
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 208 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 267
Query: 426 GEDVNEFKPER 436
+ +F PER
Sbjct: 268 WTEPEKFCPER 278
>AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 420
Score = 85.0 bits (201), Expect = 6e-16
Identities = 41/126 (32%), Positives = 71/126 (56%), Gaps = 1/126 (0%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
E++ + +F YDTTS TL +++ L T+ DVQQK+ EEI V ++ V D L +
Sbjct: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 352
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ Y + V+ E+LRL+P+ + R +D++IN + G + +Y ++ + + +
Sbjct: 353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
Query: 172 KFRPER 177
KF PER
Sbjct: 413 KFCPER 418
Score = 55.6 bits (128), Expect = 4e-07
Identities = 31/131 (23%), Positives = 66/131 (50%), Gaps = 1/131 (0%)
Query: 306 ALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEK 365
AL+D E+ + I A +DT+S L +++ L + P+VQ + EI D + +
Sbjct: 289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTY 347
Query: 366 EDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVW 425
+ L ++ Y + V+ ET+RL+ + R ++D+++ + G + ++ ++ +
Sbjct: 348 DALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKY 407
Query: 426 GEDVNEFKPER 436
+ +F PER
Sbjct: 408 WTEPEKFCPER 418
>Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for
aromatase P-450. ).
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS--------TEEKLEECMDFATELI 283
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 342
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 402 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
Query: 480 KI 481
+
Sbjct: 459 HV 460
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 366
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 423
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 424 --YRYFQPFGFGPRGCAG 439
>X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for
aromatase (estrogen synthetase). ).
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS--------TEEKLEECMDFATELI 283
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 342
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 402 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
Query: 480 KI 481
+
Sbjct: 459 HV 460
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 366
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 423
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 424 --YRYFQPFGFGPRGCAG 439
>M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase
cytochrome P-450 gene, exon 10. ).
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS--------TEEKLEECMDFATELI 283
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 342
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 402 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
Query: 480 KI 481
+
Sbjct: 459 HV 460
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 366
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 423
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 424 --YRYFQPFGFGPRGCAG 439
>M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatase
protein.
Length = 419
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 148 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRCRIS--------TEEKLEECMDFATELI 199
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 200 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 258
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 259 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 317
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 318 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 374
Query: 480 KI 481
+
Sbjct: 375 HV 376
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 225 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 282
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 283 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 339
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 340 --YRYFQPFGFGPRGCAG 355
>M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase
mRNA, complete cds. ).
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS--------TEEKLEECMDFATELI 283
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 342
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 402 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
Query: 480 KI 481
+
Sbjct: 459 HV 460
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 366
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 423
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 424 --YRYFQPFGFGPRGCAG 439
>M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase
(Aro1) mRNA, complete cds. ).
Length = 419
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 148 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS--------TEEKLEECMDFATELI 199
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 200 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 258
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 259 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 317
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 318 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 374
Query: 480 KI 481
+
Sbjct: 375 HV 376
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 225 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 282
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 283 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 339
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 340 --YRYFQPFGFGPRGCAG 355
>J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein.
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRCRIS--------TEEKLEECMDFATELI 283
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 342
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 402 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
Query: 480 KI 481
+
Sbjct: 459 HV 460
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 366
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 423
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 424 --YRYFQPFGFGPRGCAG 439
>DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfamily
19 subfamily A polypeptide 1 protein.
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS--------TEEKLEECMDFATELI 283
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 342
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 402 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
Query: 480 KI 481
+
Sbjct: 459 HV 460
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 366
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 423
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 424 --YRYFQPFGFGPRGCAG 439
>BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS--------TEEKLEECMDFATELI 283
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 342
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 402 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
Query: 480 KI 481
+
Sbjct: 459 HV 460
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 366
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 423
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 424 --YRYFQPFGFGPRGCAG 439
>BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS--------TEEKLEECMDFATELI 283
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 342
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 402 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
Query: 480 KI 481
+
Sbjct: 459 HV 460
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 366
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 423
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 424 --YRYFQPFGFGPRGCAG 439
>AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 83.8 bits (198), Expect = 1e-15
Identities = 59/242 (24%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 243 DFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLMLKLA 302
D + ++ + K+ ++ ++ + + +IA KR ++ T+ K + +D +L
Sbjct: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS--------TEEKLEECMDFATELI 283
Query: 303 ---KEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDS 359
K LT + + + + ++A DT S L ++L + P V++ EI V G+
Sbjct: 284 LAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE- 342
Query: 360 DRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGI 419
RD++ +D+ KL E + E+MR + + +R ED + + +K GT+ +++ +
Sbjct: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401
Query: 420 NRHTVWGEDVNEFKPERWLDPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
+R + + NEF E + + +P F F G R C G+ A+ +MK L LLR++
Sbjct: 402 HRLEFFPKP-NEFTLENFA--KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458
Query: 480 KI 481
+
Sbjct: 459 HV 460
Score = 70.1 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 7/138 (5%)
Query: 66 DTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESLRL 125
DT S +L ++L + + +V++ + +EI+ V G ERD++ DD+ KL E I ES+R
Sbjct: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVMENFIYESMRY 366
Query: 126 YPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEPDGVP 185
P+ ++ R+ +D I+ Y +K G +N+ ++R + ++F E + + VP
Sbjct: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAK--NVP 423
Query: 186 SVYYAFATFGVGKRACIG 203
Y F FG G R C G
Sbjct: 424 --YRYFQPFGFGPRGCAG 439
>AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13
variant 5 protein.
Length = 494
Score = 82.2 bits (194), Expect = 4e-15
Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 4/171 (2%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ YTEAV+ E
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHEI 359
Query: 382 MRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R M P+ L H + +D K ++F L GT+ L + R + + +F P+ +LD
Sbjct: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419
Query: 441 --QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR C G A + + +++ ++ S D
Sbjct: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
Score = 71.7 bits (168), Expect = 6e-12
Identities = 44/143 (30%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +T S TL Y + L + +V+ K++EEI V G R + +D +K+ YTEAVI E
Sbjct: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHE 358
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R + P+ + +++D K ++ L G + + R + + F P+ +L+
Sbjct: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
G AF F +GKR C G
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFG 441
>AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13
variant 3 protein.
Length = 494
Score = 82.2 bits (194), Expect = 4e-15
Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 4/171 (2%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ YTEAV+ E
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHEI 359
Query: 382 MRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R M P+ L H + +D K ++F L GT+ L + R + + +F P+ +LD
Sbjct: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419
Query: 441 --QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR C G A + + +++ ++ S D
Sbjct: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
Score = 71.7 bits (168), Expect = 6e-12
Identities = 44/143 (30%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +T S TL Y + L + +V+ K++EEI V G R + +D +K+ YTEAVI E
Sbjct: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHE 358
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R + P+ + +++D K ++ L G + + R + + F P+ +L+
Sbjct: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
G AF F +GKR C G
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFG 441
>AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13
variant 2 protein.
Length = 494
Score = 82.2 bits (194), Expect = 4e-15
Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 4/171 (2%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ YTEAV+ E
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHEI 359
Query: 382 MRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R M P+ L H + +D K ++F L GT+ L + R + + +F P+ +LD
Sbjct: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419
Query: 441 --QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR C G A + + +++ ++ S D
Sbjct: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
Score = 71.7 bits (168), Expect = 6e-12
Identities = 44/143 (30%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +T S TL Y + L + +V+ K++EEI V G R + +D +K+ YTEAVI E
Sbjct: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHE 358
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R + P+ + +++D K ++ L G + + R + + F P+ +L+
Sbjct: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
G AF F +GKR C G
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFG 441
>AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13
variant 1 protein.
Length = 494
Score = 82.2 bits (194), Expect = 4e-15
Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 4/171 (2%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ YTEAV+ E
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHEI 359
Query: 382 MRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R M P+ L H + +D K ++F L GT+ L + R + + +F P+ +LD
Sbjct: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419
Query: 441 --QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR C G A + + +++ ++ S D
Sbjct: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
Score = 71.7 bits (168), Expect = 6e-12
Identities = 44/143 (30%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +T S TL Y + L + +V+ K++EEI V G R + +D +K+ YTEAVI E
Sbjct: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHE 358
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R + P+ + +++D K ++ L G + + R + + F P+ +L+
Sbjct: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
G AF F +GKR C G
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFG 441
>AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13
protein.
Length = 494
Score = 82.2 bits (194), Expect = 4e-15
Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 4/171 (2%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ YTEAV+ E
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHEI 359
Query: 382 MRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R M P+ L H + +D K ++F L GT+ L + R + + +F P+ +LD
Sbjct: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419
Query: 441 --QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR C G A + + +++ ++ S D
Sbjct: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
Score = 71.7 bits (168), Expect = 6e-12
Identities = 44/143 (30%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +T S TL Y + L + +V+ K++EEI V G R + +D +K+ YTEAVI E
Sbjct: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHE 358
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R + P+ + +++D K ++ L G + + R + + F P+ +L+
Sbjct: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
G AF F +GKR C G
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFG 441
>AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family
27, subfamily B, polypeptide 1 protein.
Length = 508
Score = 81.8 bits (193), Expect = 5e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 305 DALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLE 364
+ L Q I V ++AG DT S L + L L PEVQ ++EI
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
Query: 365 KED-LSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHT 423
LS+L +AV+KE +RLY + P + R ++D+ + ++ + T ++ + +R
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDP 419
Query: 424 VWGEDVNEFKPERWLDPQKIPDNAFAA--FSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ N F+P RWL P + FA+ F GKRSC GR A +++ LA +L +++
Sbjct: 420 AQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEV 478
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDD-LSK 111
IL + + G DT S TL++ L L + +VQ ++ EI S LS+
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L +AV+KE LRLYP+ P R D+D+ + +Y + + Y +R + +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
FRP RWL P +A FG GKR+C+G
Sbjct: 427 SFRPARWLGEGPTPHP-FASLPFGFGKRSCMG 457
>AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 81.8 bits (193), Expect = 5e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 305 DALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLE 364
+ L Q I V ++AG DT S L + L L PEVQ ++EI
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
Query: 365 KED-LSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHT 423
LS+L +AV+KE +RLY + P + R ++D+ + ++ + T ++ + +R
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDP 419
Query: 424 VWGEDVNEFKPERWLDPQKIPDNAFAA--FSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ N F+P RWL P + FA+ F GKRSC GR A +++ LA +L +++
Sbjct: 420 AQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEV 478
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDD-LSK 111
IL + + G DT S TL++ L L + +VQ ++ EI S LS+
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L +AV+KE LRLYP+ P R D+D+ + +Y + + Y +R + +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
FRP RWL P +A FG GKR+C+G
Sbjct: 427 SFRPARWLGEGPTPHP-FASLPFGFGKRSCMG 457
>AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 81.8 bits (193), Expect = 5e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 305 DALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLE 364
+ L Q I V ++AG DT S L + L L PEVQ ++EI
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
Query: 365 KED-LSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHT 423
LS+L +AV+KE +RLY + P + R ++D+ + ++ + T ++ + +R
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDP 419
Query: 424 VWGEDVNEFKPERWLDPQKIPDNAFAA--FSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ N F+P RWL P + FA+ F GKRSC GR A +++ LA +L +++
Sbjct: 420 AQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEV 478
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDD-LSK 111
IL + + G DT S TL++ L L + +VQ ++ EI S LS+
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L +AV+KE LRLYP+ P R D+D+ + +Y + + Y +R + +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
FRP RWL P +A FG GKR+C+G
Sbjct: 427 SFRPARWLGEGPTPHP-FASLPFGFGKRSCMG 457
>AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin D-1
alpha hydroxylase protein.
Length = 508
Score = 81.8 bits (193), Expect = 5e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 305 DALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLE 364
+ L Q I V ++AG DT S L + L L PEVQ ++EI
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
Query: 365 KED-LSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHT 423
LS+L +AV+KE +RLY + P + R ++D+ + ++ + T ++ + +R
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDP 419
Query: 424 VWGEDVNEFKPERWLDPQKIPDNAFAA--FSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ N F+P RWL P + FA+ F GKRSC GR A +++ LA +L +++
Sbjct: 420 AQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEV 478
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDD-LSK 111
IL + + G DT S TL++ L L + +VQ ++ EI S LS+
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L +AV+KE LRLYP+ P R D+D+ + +Y + + Y +R + +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
FRP RWL P +A FG GKR+C+G
Sbjct: 427 SFRPARWLGEGPTPHP-FASLPFGFGKRSCMG 457
>AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 81.8 bits (193), Expect = 5e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 305 DALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLE 364
+ L Q I V ++AG DT S L + L L PEVQ ++EI
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
Query: 365 KED-LSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHT 423
LS+L +AV+KE +RLY + P + R ++D+ + ++ + T ++ + +R
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDP 419
Query: 424 VWGEDVNEFKPERWLDPQKIPDNAFAA--FSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ N F+P RWL P + FA+ F GKRSC GR A +++ LA +L +++
Sbjct: 420 AQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEV 478
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDD-LSK 111
IL + + G DT S TL++ L L + +VQ ++ EI S LS+
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L +AV+KE LRLYP+ P R D+D+ + +Y + + Y +R + +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
FRP RWL P +A FG GKR+C+G
Sbjct: 427 SFRPARWLGEGPTPHP-FASLPFGFGKRSCMG 457
>AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 81.8 bits (193), Expect = 5e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 305 DALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLE 364
+ L Q I V ++AG DT S L + L L PEVQ ++EI
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
Query: 365 KED-LSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHT 423
LS+L +AV+KE +RLY + P + R ++D+ + ++ + T ++ + +R
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDP 419
Query: 424 VWGEDVNEFKPERWLDPQKIPDNAFAA--FSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ N F+P RWL P + FA+ F GKRSC GR A +++ LA +L +++
Sbjct: 420 AQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEV 478
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDD-LSK 111
IL + + G DT S TL++ L L + +VQ ++ EI S LS+
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L +AV+KE LRLYP+ P R D+D+ + +Y + + Y +R + +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
FRP RWL P +A FG GKR+C+G
Sbjct: 427 SFRPARWLGEGPTPHP-FASLPFGFGKRSCMG 457
>AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 81.8 bits (193), Expect = 5e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 305 DALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLE 364
+ L Q I V ++AG DT S L + L L PEVQ ++EI
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
Query: 365 KED-LSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHT 423
LS+L +AV+KE +RLY + P + R ++D+ + ++ + T ++ + +R
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDP 419
Query: 424 VWGEDVNEFKPERWLDPQKIPDNAFAA--FSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ N F+P RWL P + FA+ F GKRSC GR A +++ LA +L +++
Sbjct: 420 AQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEV 478
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDD-LSK 111
IL + + G DT S TL++ L L + +VQ ++ EI S LS+
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L +AV+KE LRLYP+ P R D+D+ + +Y + + Y +R + +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
FRP RWL P +A FG GKR+C+G
Sbjct: 427 SFRPARWLGEGPTPHP-FASLPFGFGKRSCMG 457
>AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 81.8 bits (193), Expect = 5e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 305 DALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLE 364
+ L Q I V ++AG DT S L + L L PEVQ ++EI
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
Query: 365 KED-LSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHT 423
LS+L +AV+KE +RLY + P + R ++D+ + ++ + T ++ + +R
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDP 419
Query: 424 VWGEDVNEFKPERWLDPQKIPDNAFAA--FSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ N F+P RWL P + FA+ F GKRSC GR A +++ LA +L +++
Sbjct: 420 AQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEV 478
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDD-LSK 111
IL + + G DT S TL++ L L + +VQ ++ EI S LS+
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L +AV+KE LRLYP+ P R D+D+ + +Y + + Y +R + +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
FRP RWL P +A FG GKR+C+G
Sbjct: 427 SFRPARWLGEGPTPHP-FASLPFGFGKRSCMG 457
>AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 81.8 bits (193), Expect = 5e-15
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 305 DALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLE 364
+ L Q I V ++AG DT S L + L L PEVQ ++EI
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359
Query: 365 KED-LSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHT 423
LS+L +AV+KE +RLY + P + R ++D+ + ++ + T ++ + +R
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDP 419
Query: 424 VWGEDVNEFKPERWLDPQKIPDNAFAA--FSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ N F+P RWL P + FA+ F GKRSC GR A +++ LA +L +++
Sbjct: 420 AQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEV 478
Score = 81.8 bits (193), Expect = 5e-15
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDD-LSK 111
IL + + G DT S TL++ L L + +VQ ++ EI S LS+
Sbjct: 307 ILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQ 366
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
L +AV+KE LRLYP+ P R D+D+ + +Y + + Y +R + +
Sbjct: 367 LPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPN 426
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
FRP RWL P +A FG GKR+C+G
Sbjct: 427 SFRPARWLGEGPTPHP-FASLPFGFGKRSCMG 457
>M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 81.0 bits (191), Expect = 9e-15
Identities = 54/172 (31%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRTKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +LD
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR C G A + + +++ +++ S D
Sbjct: 419 DKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 70.1 bits (164), Expect = 2e-11
Identities = 45/152 (29%), Positives = 75/152 (49%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + G +T S TL Y + L + +V+ K++EEI V G + R + +D +K+
Sbjct: 292 MMSTLNLFI-AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKN-RQPKFEDRTKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQ 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L+ G AF F +GKR C G
Sbjct: 410 DFNPQHFLDDKGQFKKSDAFVPFSIGKRYCFG 441
>BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 7 protein.
Length = 494
Score = 81.0 bits (191), Expect = 9e-15
Identities = 54/172 (31%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +LD
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR C G A + + +++ +++ S D
Sbjct: 419 DKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 70.1 bits (164), Expect = 2e-11
Identities = 45/152 (29%), Positives = 75/152 (49%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + G +T S TL Y + L + +V+ K++EEI V G + R + +D +K+
Sbjct: 292 MMSTLNLFI-AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKN-RQPKFEDRAKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQ 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L+ G AF F +GKR C G
Sbjct: 410 DFNPQHFLDDKGQFKKSDAFVPFSIGKRYCFG 441
>BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 81.0 bits (191), Expect = 9e-15
Identities = 42/144 (29%), Positives = 75/144 (52%), Gaps = 2/144 (1%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIK 120
+ G +TT+ L + ++ + Y ++Q ++ +EI + G + + DD K+ YTEAV+
Sbjct: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLH 366
Query: 121 ESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWL 179
E LR I P+ IF +D + Y++ G N+Y ++ + D + F PER+L
Sbjct: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426
Query: 180 EPDGVPSVYYAFATFGVGKRACIG 203
+ G + A F +G+R C+G
Sbjct: 427 DSSGYFAKKEALVPFSLGRRHCLG 450
Score = 77.0 bits (181), Expect = 1e-13
Identities = 46/169 (27%), Positives = 85/169 (50%), Gaps = 4/169 (2%)
Query: 316 VDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTE 375
V I+AG +T++ +L + ++ + +P +Q + EI + G + + +D K+ YTE
Sbjct: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTE 362
Query: 376 AVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKP 434
AVL E +R + P+ + H ED ++ +++ GT +L+ ++ + D F P
Sbjct: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422
Query: 435 ERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
ER+LD A FS+G+R C G A M + LL+++ +
Sbjct: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
>BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 81.0 bits (191), Expect = 9e-15
Identities = 42/144 (29%), Positives = 75/144 (52%), Gaps = 2/144 (1%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIK 120
+ G +TT+ L + ++ + Y ++Q ++ +EI + G + + DD K+ YTEAV+
Sbjct: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLH 366
Query: 121 ESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWL 179
E LR I P+ IF +D + Y++ G N+Y ++ + D + F PER+L
Sbjct: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426
Query: 180 EPDGVPSVYYAFATFGVGKRACIG 203
+ G + A F +G+R C+G
Sbjct: 427 DSSGYFAKKEALVPFSLGRRHCLG 450
Score = 77.0 bits (181), Expect = 1e-13
Identities = 46/169 (27%), Positives = 85/169 (50%), Gaps = 4/169 (2%)
Query: 316 VDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTE 375
V I+AG +T++ +L + ++ + +P +Q + EI + G + + +D K+ YTE
Sbjct: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTE 362
Query: 376 AVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKP 434
AVL E +R + P+ + H ED ++ +++ GT +L+ ++ + D F P
Sbjct: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422
Query: 435 ERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
ER+LD A FS+G+R C G A M + LL+++ +
Sbjct: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
>AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13
variant 6 protein.
Length = 494
Score = 81.0 bits (191), Expect = 9e-15
Identities = 54/171 (31%), Positives = 85/171 (49%), Gaps = 4/171 (2%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T S L Y + L PE++ + + EI V G +R + ED +K+ YTEAV+ E
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPELEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHEI 359
Query: 382 MRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R M P+ L H + +D K ++F L GT+ L + R + + +F P+ +LD
Sbjct: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419
Query: 441 --QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR C G A + + +++ ++ S D
Sbjct: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
Score = 70.5 bits (165), Expect = 1e-11
Identities = 43/143 (30%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +T S TL Y + L + +++ K++EEI V G R + +D +K+ YTEAVI E
Sbjct: 300 FAGTETVSTTLRYGFLLLMKHPELEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHE 358
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R + P+ + +++D K ++ L G + + R + + F P+ +L+
Sbjct: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
G AF F +GKR C G
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFG 441
>AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1
protein.
Length = 501
Score = 81.0 bits (191), Expect = 9e-15
Identities = 42/144 (29%), Positives = 75/144 (52%), Gaps = 2/144 (1%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIK 120
+ G +TT+ L + ++ + Y ++Q ++ +EI + G + + DD K+ YTEAV+
Sbjct: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLH 366
Query: 121 ESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWL 179
E LR I P+ IF +D + Y++ G N+Y ++ + D + F PER+L
Sbjct: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426
Query: 180 EPDGVPSVYYAFATFGVGKRACIG 203
+ G + A F +G+R C+G
Sbjct: 427 DSSGYFAKKEALVPFSLGRRHCLG 450
Score = 77.0 bits (181), Expect = 1e-13
Identities = 46/169 (27%), Positives = 85/169 (50%), Gaps = 4/169 (2%)
Query: 316 VDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTE 375
V I+AG +T++ +L + ++ + +P +Q + EI + G + + +D K+ YTE
Sbjct: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTE 362
Query: 376 AVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKP 434
AVL E +R + P+ + H ED ++ +++ GT +L+ ++ + D F P
Sbjct: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422
Query: 435 ERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
ER+LD A FS+G+R C G A M + LL+++ +
Sbjct: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
>M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid
11-beta-hydroxylase-like-enzyme (CYP11B2) gene, exon 9.
).
Length = 503
Score = 80.2 bits (189), Expect = 2e-14
Identities = 56/213 (26%), Positives = 100/213 (46%), Gaps = 5/213 (2%)
Query: 289 NKYQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRA 348
N+ Q ++ +L + L+ + I+ DT+++ L+ L L P+VQ
Sbjct: 281 NRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQIL 340
Query: 349 YNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKA 408
E + +K ++L A LKET+RLY +G R + D+ L+N+ + A
Sbjct: 341 RKESLAAAASISEHPQKAT-TELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPA 399
Query: 409 GTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNA-FAAFSIGKRSCTGRAYALTL 467
GT + L+ + R+ + P+RWLD + N F G R C GR A
Sbjct: 400 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNLHHVPFGFGMRQCLGRRLAEAE 459
Query: 468 MKINLAHLLRKYKISGDVSKLDFK--FNFIIKP 498
M + L H+L+++ + +++ D K ++FI++P
Sbjct: 460 MLLLLHHVLKRFLVE-TLTQEDIKMVYSFILRP 491
Score = 69.3 bits (162), Expect = 3e-11
Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 4/142 (2%)
Query: 63 GGYDTTSCTLTYVLMNLGTYQDVQQKMYEE-IKNVFGDSERDVESDDLSKLVYTEAVIKE 121
G DTT+ L L L DVQQ + +E + SE ++ ++L A +KE
Sbjct: 314 GSVDTTAFPLLMTLFELARNPDVQQILRKESLAAAASISEHPQKAT--TELPLLRAALKE 371
Query: 122 SLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEP 181
+LRLYP+ + R + D+ + NY + AG + +Y + R+A +++ P+RWL+
Sbjct: 372 TLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDI 431
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G + FG G R C+G
Sbjct: 432 RGSGRNLH-HVPFGFGMRQCLG 452
>DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6
protein.
Length = 496
Score = 80.2 bits (189), Expect = 2e-14
Identities = 56/192 (29%), Positives = 89/192 (46%), Gaps = 4/192 (2%)
Query: 294 LLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIM 353
L ++ K E + D+ +R V AG T+S L + L+ + P+VQ R EI
Sbjct: 276 LAEMEAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEID 335
Query: 354 DVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDC 412
DV G R E D + + YT AV+ E R + P+ + H+ D++++ F + GT
Sbjct: 336 DVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTL 394
Query: 413 SISLFGINRHTVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKI 470
+L + + E F PE +LD Q + AF FS G+R+C G A + +
Sbjct: 395 ITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFL 454
Query: 471 NLAHLLRKYKIS 482
LL+ + S
Sbjct: 455 FFTSLLQHFSFS 466
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 305 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 363
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 364 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 422
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 423 QGHFVKPEAFLPFSAGRRACLG 444
>X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein.
Length = 497
Score = 79.8 bits (188), Expect = 2e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.3 bits (162), Expect = 3e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPIIFREL-DQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein.
Length = 497
Score = 79.8 bits (188), Expect = 2e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.3 bits (162), Expect = 3e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPIIFREL-DQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family 2,
subfamily U, polypeptide 1 protein.
Length = 544
Score = 79.8 bits (188), Expect = 2e-14
Identities = 49/162 (30%), Positives = 86/162 (53%), Gaps = 4/162 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+AG DT++ L++ L+ + P+VQ++ + EI V G ++R D +++ YTEA + E
Sbjct: 351 IAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIG-ANRAPSLTDKAQMPYTEATIME 409
Query: 381 TMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
RL + P+++ H+ E+ L+ +T+ GT +L+ ++R E +F P R+LD
Sbjct: 410 VQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLD 469
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
Q I F F IGKR C G A + + L++ +
Sbjct: 470 DQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
Score = 79.8 bits (188), Expect = 2e-14
Identities = 47/142 (33%), Positives = 76/142 (53%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G DTT+ +L + L+ + DVQ+K++EEI+ V G + R D +++ YTEA I E
Sbjct: 353 GTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIG-ANRAPSLTDKAQMPYTEATIMEVQ 411
Query: 124 RLYPIAPIIFREL-DQDVKINNYTLKAGRGCAINVYGINRH-AMWGDDADKFRPERWLEP 181
RL + P+ + ++ + YT+ G N++ ++R A+W D F P R+L+
Sbjct: 412 RLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPED-FYPNRFLDD 470
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G F FG+GKR C+G
Sbjct: 471 QGQLIKKETFIPFGIGKRVCMG 492
>AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein.
Length = 544
Score = 79.8 bits (188), Expect = 2e-14
Identities = 49/162 (30%), Positives = 86/162 (53%), Gaps = 4/162 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+AG DT++ L++ L+ + P+VQ++ + EI V G ++R D +++ YTEA + E
Sbjct: 351 IAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIG-ANRAPSLTDKAQMPYTEATIME 409
Query: 381 TMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
RL + P+++ H+ E+ L+ +T+ GT +L+ ++R E +F P R+LD
Sbjct: 410 VQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLD 469
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKY 479
Q I F F IGKR C G A + + L++ +
Sbjct: 470 DQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
Score = 79.8 bits (188), Expect = 2e-14
Identities = 47/142 (33%), Positives = 76/142 (53%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G DTT+ +L + L+ + DVQ+K++EEI+ V G + R D +++ YTEA I E
Sbjct: 353 GTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIG-ANRAPSLTDKAQMPYTEATIMEVQ 411
Query: 124 RLYPIAPIIFREL-DQDVKINNYTLKAGRGCAINVYGINRH-AMWGDDADKFRPERWLEP 181
RL + P+ + ++ + YT+ G N++ ++R A+W D F P R+L+
Sbjct: 412 RLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPED-FYPNRFLDD 470
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G F FG+GKR C+G
Sbjct: 471 QGQLIKKETFIPFGIGKRVCMG 492
>M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 9/149 (6%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G +TT+ + + L L V++K+YEEI G S SD ++L+ EA I
Sbjct: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDR-NRLLLLEATI 357
Query: 120 KESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
+E LRL P+AP++ + + D I + + G IN++ ++ + D+F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 179 LEPDGV----PSVYYAFATFGVGKRACIG 203
L P G PSV Y FG G R+CIG
Sbjct: 418 LNPAGTQLISPSVSY--LPFGAGPRSCIG 444
Score = 77.4 bits (182), Expect = 1e-13
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 15/252 (5%)
Query: 239 WLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLM 298
WL+I L +K ++I N++ NKI+ + + S + N D Q ++
Sbjct: 220 WLKIFPNKTLEKLKSH----VKIRNDLLNKILENYKEKFRSD-SITNMLDTLMQAKMNSD 274
Query: 299 LKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD 354
A D L+D I + AG +T++ ++ + L L P+V+ + Y EI
Sbjct: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334
Query: 355 VFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCS 413
G S R D ++L+ EA ++E +RL + P+ + H D + F + GT+
Sbjct: 335 NVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393
Query: 414 ISLFGINRHTVWGEDVNEFKPERWLDP---QKI-PDNAFAAFSIGKRSCTGRAYALTLMK 469
I+L+ ++ + ++F PER+L+P Q I P ++ F G RSC G A +
Sbjct: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453
Query: 470 INLAHLLRKYKI 481
+ +A LL+++ +
Sbjct: 454 LIMAWLLQRFDL 465
>M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoquine
4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
cds. ).
Length = 500
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 290 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 348
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 349 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 408
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 409 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 468
Query: 481 IS 482
S
Sbjct: 469 FS 470
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 309 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 367
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 368 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 426
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 427 QGHFVKPEAFLPFSAGRRACLG 448
>M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 9/149 (6%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G +TT+ + + L L V++K+YEEI G S SD ++L+ EA I
Sbjct: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDR-NRLLLLEATI 357
Query: 120 KESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
+E LRL P+AP++ + + D I + + G IN++ ++ + D+F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 179 LEPDGV----PSVYYAFATFGVGKRACIG 203
L P G PSV Y FG G R+CIG
Sbjct: 418 LNPAGTQLISPSVSY--LPFGAGPRSCIG 444
Score = 77.4 bits (182), Expect = 1e-13
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 15/252 (5%)
Query: 239 WLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLM 298
WL+I L +K ++I N++ NKI+ + + S + N D Q ++
Sbjct: 220 WLKIFPNKTLEKLKSH----VKIRNDLLNKILENYKEKFRSD-SITNMLDTLMQAKMNSD 274
Query: 299 LKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD 354
A D L+D I + AG +T++ ++ + L L P+V+ + Y EI
Sbjct: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334
Query: 355 VFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCS 413
G S R D ++L+ EA ++E +RL + P+ + H D + F + GT+
Sbjct: 335 NVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393
Query: 414 ISLFGINRHTVWGEDVNEFKPERWLDP---QKI-PDNAFAAFSIGKRSCTGRAYALTLMK 469
I+L+ ++ + ++F PER+L+P Q I P ++ F G RSC G A +
Sbjct: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453
Query: 470 INLAHLLRKYKI 481
+ +A LL+++ +
Sbjct: 454 LIMAWLLQRFDL 465
>M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein.
Length = 373
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 163 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 221
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 222 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 281
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 282 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 341
Query: 481 IS 482
S
Sbjct: 342 FS 343
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 182 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 240
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 241 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 299
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 300 QGHFVKPEAFLPFSAGRRACLG 321
>M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 9/149 (6%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G +TT+ + + L L V++K+YEEI G S SD ++L+ EA I
Sbjct: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDR-NRLLLLEATI 357
Query: 120 KESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
+E LRL P+AP++ + + D I + + G IN++ ++ + D+F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 179 LEPDGV----PSVYYAFATFGVGKRACIG 203
L P G PSV Y FG G R+CIG
Sbjct: 418 LNPAGTQLISPSVSY--LPFGAGPRSCIG 444
Score = 77.4 bits (182), Expect = 1e-13
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 15/252 (5%)
Query: 239 WLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLM 298
WL+I L +K ++I N++ NKI+ + + S + N D Q ++
Sbjct: 220 WLKIFPNKTLEKLKSH----VKIRNDLLNKILENYKEKFRSD-SITNMLDTLMQAKMNSD 274
Query: 299 LKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD 354
A D L+D I + AG +T++ ++ + L L P+V+ + Y EI
Sbjct: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334
Query: 355 VFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCS 413
G S R D ++L+ EA ++E +RL + P+ + H D + F + GT+
Sbjct: 335 NVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393
Query: 414 ISLFGINRHTVWGEDVNEFKPERWLDP---QKI-PDNAFAAFSIGKRSCTGRAYALTLMK 469
I+L+ ++ + ++F PER+L+P Q I P ++ F G RSC G A +
Sbjct: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453
Query: 470 INLAHLLRKYKI 481
+ +A LL+++ +
Sbjct: 454 LIMAWLLQRFDL 465
>M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein.
Length = 508
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 9/149 (6%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G +TT+ + + L L V++K+YEEI G S SD ++L+ EA I
Sbjct: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDR-NRLLLLEATI 357
Query: 120 KESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
+E LRL P+AP++ + + D I + + G IN++ ++ + D+F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 179 LEPDGV----PSVYYAFATFGVGKRACIG 203
L P G PSV Y FG G R+CIG
Sbjct: 418 LNPAGTQLISPSVSY--LPFGAGPRSCIG 444
Score = 77.4 bits (182), Expect = 1e-13
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 15/252 (5%)
Query: 239 WLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLM 298
WL+I L +K ++I N++ NKI+ + + S + N D Q ++
Sbjct: 220 WLKIFPNKTLEKLKSH----VKIRNDLLNKILENYKEKFRSD-SITNMLDTLMQAKMNSD 274
Query: 299 LKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD 354
A D L+D I + AG +T++ ++ + L L P+V+ + Y EI
Sbjct: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334
Query: 355 VFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCS 413
G S R D ++L+ EA ++E +RL + P+ + H D + F + GT+
Sbjct: 335 NVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393
Query: 414 ISLFGINRHTVWGEDVNEFKPERWLDP---QKI-PDNAFAAFSIGKRSCTGRAYALTLMK 469
I+L+ ++ + ++F PER+L+P Q I P ++ F G RSC G A +
Sbjct: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453
Query: 470 INLAHLLRKYKI 481
+ +A LL+++ +
Sbjct: 454 LIMAWLLQRFDL 465
>DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 9/149 (6%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G +TT+ + + L L V++K+YEEI G S SD ++L+ EA I
Sbjct: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDR-NRLLLLEATI 357
Query: 120 KESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
+E LRL P+AP++ + + D I + + G IN++ ++ + D+F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 179 LEPDGV----PSVYYAFATFGVGKRACIG 203
L P G PSV Y FG G R+CIG
Sbjct: 418 LNPAGTQLISPSVSY--LPFGAGPRSCIG 444
Score = 77.4 bits (182), Expect = 1e-13
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 15/252 (5%)
Query: 239 WLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLM 298
WL+I L +K ++I N++ NKI+ + + S + N D Q ++
Sbjct: 220 WLKIFPNKTLEKLKSH----VKIRNDLLNKILENYKEKFRSD-SITNMLDTLMQAKMNSD 274
Query: 299 LKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD 354
A D L+D I + AG +T++ ++ + L L P+V+ + Y EI
Sbjct: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334
Query: 355 VFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCS 413
G S R D ++L+ EA ++E +RL + P+ + H D + F + GT+
Sbjct: 335 NVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393
Query: 414 ISLFGINRHTVWGEDVNEFKPERWLDP---QKI-PDNAFAAFSIGKRSCTGRAYALTLMK 469
I+L+ ++ + ++F PER+L+P Q I P ++ F G RSC G A +
Sbjct: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453
Query: 470 INLAHLLRKYKI 481
+ +A LL+++ +
Sbjct: 454 LIMAWLLQRFDL 465
>DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 9/149 (6%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G +TT+ + + L L V++K+YEEI G S SD ++L+ EA I
Sbjct: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDR-NRLLLLEATI 357
Query: 120 KESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
+E LRL P+AP++ + + D I + + G IN++ ++ + D+F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 179 LEPDGV----PSVYYAFATFGVGKRACIG 203
L P G PSV Y FG G R+CIG
Sbjct: 418 LNPAGTQLISPSVSY--LPFGAGPRSCIG 444
Score = 77.4 bits (182), Expect = 1e-13
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 15/252 (5%)
Query: 239 WLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLM 298
WL+I L +K ++I N++ NKI+ + + S + N D Q ++
Sbjct: 220 WLKIFPNKTLEKLKSH----VKIRNDLLNKILENYKEKFRSD-SITNMLDTLMQAKMNSD 274
Query: 299 LKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD 354
A D L+D I + AG +T++ ++ + L L P+V+ + Y EI
Sbjct: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334
Query: 355 VFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCS 413
G S R D ++L+ EA ++E +RL + P+ + H D + F + GT+
Sbjct: 335 NVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393
Query: 414 ISLFGINRHTVWGEDVNEFKPERWLDP---QKI-PDNAFAAFSIGKRSCTGRAYALTLMK 469
I+L+ ++ + ++F PER+L+P Q I P ++ F G RSC G A +
Sbjct: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453
Query: 470 INLAHLLRKYKI 481
+ +A LL+++ +
Sbjct: 454 LIMAWLLQRFDL 465
>BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 9/149 (6%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G +TT+ + + L L V++K+YEEI G S SD ++L+ EA I
Sbjct: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDR-NRLLLLEATI 357
Query: 120 KESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
+E LRL P+AP++ + + D I + + G IN++ ++ + D+F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 179 LEPDGV----PSVYYAFATFGVGKRACIG 203
L P G PSV Y FG G R+CIG
Sbjct: 418 LNPAGTQLISPSVSY--LPFGAGPRSCIG 444
Score = 77.4 bits (182), Expect = 1e-13
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 15/252 (5%)
Query: 239 WLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLM 298
WL+I L +K ++I N++ NKI+ + + S + N D Q ++
Sbjct: 220 WLKIFPNKTLEKLKSH----VKIRNDLLNKILENYKEKFRSD-SITNMLDTLMQAKMNSD 274
Query: 299 LKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD 354
A D L+D I + AG +T++ ++ + L L P+V+ + Y EI
Sbjct: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334
Query: 355 VFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCS 413
G S R D ++L+ EA ++E +RL + P+ + H D + F + GT+
Sbjct: 335 NVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393
Query: 414 ISLFGINRHTVWGEDVNEFKPERWLDP---QKI-PDNAFAAFSIGKRSCTGRAYALTLMK 469
I+L+ ++ + ++F PER+L+P Q I P ++ F G RSC G A +
Sbjct: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453
Query: 470 INLAHLLRKYKI 481
+ +A LL+++ +
Sbjct: 454 LIMAWLLQRFDL 465
>BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 9/149 (6%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G +TT+ + + L L V++K+YEEI G S SD ++L+ EA I
Sbjct: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDR-NRLLLLEATI 357
Query: 120 KESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
+E LRL P+AP++ + + D I + + G IN++ ++ + D+F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 179 LEPDGV----PSVYYAFATFGVGKRACIG 203
L P G PSV Y FG G R+CIG
Sbjct: 418 LNPAGTQLISPSVSY--LPFGAGPRSCIG 444
Score = 77.4 bits (182), Expect = 1e-13
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 15/252 (5%)
Query: 239 WLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLM 298
WL+I L +K ++I N++ NKI+ + + S + N D Q ++
Sbjct: 220 WLKIFPNKTLEKLKSH----VKIRNDLLNKILENYKEKFRSD-SITNMLDTLMQAKMNSD 274
Query: 299 LKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD 354
A D L+D I + AG +T++ ++ + L L P+V+ + Y EI
Sbjct: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334
Query: 355 VFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCS 413
G S R D ++L+ EA ++E +RL + P+ + H D + F + GT+
Sbjct: 335 NVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393
Query: 414 ISLFGINRHTVWGEDVNEFKPERWLDP---QKI-PDNAFAAFSIGKRSCTGRAYALTLMK 469
I+L+ ++ + ++F PER+L+P Q I P ++ F G RSC G A +
Sbjct: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453
Query: 470 INLAHLLRKYKI 481
+ +A LL+++ +
Sbjct: 454 LIMAWLLQRFDL 465
>AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6
protein.
Length = 497
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family
17, subfamily A, polypeptide 1 protein.
Length = 508
Score = 79.4 bits (187), Expect = 3e-14
Identities = 52/149 (34%), Positives = 79/149 (53%), Gaps = 9/149 (6%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G +TT+ + + L L V++K+YEEI G S SD ++L+ EA I
Sbjct: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDR-NRLLLLEATI 357
Query: 120 KESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
+E LRL P+AP++ + + D I + + G IN++ ++ + D+F PER+
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417
Query: 179 LEPDGV----PSVYYAFATFGVGKRACIG 203
L P G PSV Y FG G R+CIG
Sbjct: 418 LNPAGTQLISPSVSY--LPFGAGPRSCIG 444
Score = 77.4 bits (182), Expect = 1e-13
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 15/252 (5%)
Query: 239 WLQIDFIYNLTSIKKREDELIRIVNEMSNKIIARKRSELASGVAAANETDNKYQGLLDLM 298
WL+I L +K ++I N++ NKI+ + + S + N D Q ++
Sbjct: 220 WLKIFPNKTLEKLKSH----VKIRNDLLNKILENYKEKFRSD-SITNMLDTLMQAKMNSD 274
Query: 299 LKLAKEDA----LTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD 354
A D L+D I + AG +T++ ++ + L L P+V+ + Y EI
Sbjct: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334
Query: 355 VFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCS 413
G S R D ++L+ EA ++E +RL + P+ + H D + F + GT+
Sbjct: 335 NVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393
Query: 414 ISLFGINRHTVWGEDVNEFKPERWLDP---QKI-PDNAFAAFSIGKRSCTGRAYALTLMK 469
I+L+ ++ + ++F PER+L+P Q I P ++ F G RSC G A +
Sbjct: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453
Query: 470 INLAHLLRKYKI 481
+ +A LL+++ +
Sbjct: 454 LIMAWLLQRFDL 465
>AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxylase
mutant allele variant protein.
Length = 566
Score = 79.4 bits (187), Expect = 3e-14
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ +R V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 356 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 414
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 415 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 474
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 475 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 534
Query: 481 IS 482
S
Sbjct: 535 FS 536
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 375 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 433
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 434 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 492
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 493 QGHFVKPEAFLPFSAGRRACLG 514
>X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase
(P-450aldo) protein.
Length = 503
Score = 78.6 bits (185), Expect = 5e-14
Identities = 56/213 (26%), Positives = 99/213 (46%), Gaps = 5/213 (2%)
Query: 289 NKYQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRA 348
N+ Q ++ +L + L+ + I+ DT+++ L+ L L P+VQ
Sbjct: 281 NRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQIL 340
Query: 349 YNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKA 408
E + +K ++L A LKET+RLY +G R + D+ L+N+ + A
Sbjct: 341 RQESLAAAASISEHPQKAT-TELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPA 399
Query: 409 GTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN-AFAAFSIGKRSCTGRAYALTL 467
GT + L+ + R+ + P+RWLD + N F G R C GR A
Sbjct: 400 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459
Query: 468 MKINLAHLLRKYKISGDVSKLDFK--FNFIIKP 498
M + L H+L+ + + +++ D K ++FI++P
Sbjct: 460 MLLLLHHVLKHFLVE-TLTQEDIKMVYSFILRP 491
Score = 71.3 bits (167), Expect = 7e-12
Identities = 43/142 (30%), Positives = 71/142 (50%), Gaps = 4/142 (2%)
Query: 63 GGYDTTSCTLTYVLMNLGTYQDVQQKMYEE-IKNVFGDSERDVESDDLSKLVYTEAVIKE 121
G DTT+ L L L DVQQ + +E + SE ++ ++L A +KE
Sbjct: 314 GSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT--TELPLLRAALKE 371
Query: 122 SLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEP 181
+LRLYP+ + R + D+ + NY + AG + +Y + R+A +++ P+RWL+
Sbjct: 372 TLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDI 431
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G ++ FG G R C+G
Sbjct: 432 RGSGRNFH-HVPFGFGMRQCLG 452
>X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mRNA
for P-450 IIA4 protein. ).
Length = 494
Score = 78.6 bits (185), Expect = 5e-14
Identities = 52/172 (30%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+ G +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L+
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR+C G A + + +++ +++ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 72.1 bits (169), Expect = 4e-12
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + GG +T S TL Y + L + +V+ K++EEI V G R + +D +K+
Sbjct: 292 VMTTLNLFI-GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F +GKR C G
Sbjct: 410 DFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 441
>X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is 3rd
base in codon) protein.
Length = 448
Score = 78.6 bits (185), Expect = 5e-14
Identities = 52/172 (30%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+ G +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 254 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 312
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L+
Sbjct: 313 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 372
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR+C G A + + +++ +++ S D
Sbjct: 373 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 424
Score = 72.1 bits (169), Expect = 4e-12
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + GG +T S TL Y + L + +V+ K++EEI V G R + +D +K+
Sbjct: 246 VMTTLNLFI-GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKM 303
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 304 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 363
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F +GKR C G
Sbjct: 364 DFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 395
>M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein.
Length = 494
Score = 78.6 bits (185), Expect = 5e-14
Identities = 52/172 (30%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+ G +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L+
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR+C G A + + +++ +++ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 72.1 bits (169), Expect = 4e-12
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + GG +T S TL Y + L + +V+ K++EEI V G R + +D +K+
Sbjct: 292 VMTTLNLFI-GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F +GKR C G
Sbjct: 410 DFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 441
>D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase
protein.
Length = 503
Score = 78.6 bits (185), Expect = 5e-14
Identities = 56/213 (26%), Positives = 99/213 (46%), Gaps = 5/213 (2%)
Query: 289 NKYQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRA 348
N+ Q ++ +L + L+ + I+ DT+++ L+ L L P+VQ
Sbjct: 281 NRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQIL 340
Query: 349 YNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKA 408
E + +K ++L A LKET+RLY +G R + D+ L+N+ + A
Sbjct: 341 RQESLAAAASISEHPQKAT-TELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPA 399
Query: 409 GTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDN-AFAAFSIGKRSCTGRAYALTL 467
GT + L+ + R+ + P+RWLD + N F G R C GR A
Sbjct: 400 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459
Query: 468 MKINLAHLLRKYKISGDVSKLDFK--FNFIIKP 498
M + L H+L+ + + +++ D K ++FI++P
Sbjct: 460 MLLLLHHVLKHFLVE-TLTQEDIKMVYSFILRP 491
Score = 71.3 bits (167), Expect = 7e-12
Identities = 43/142 (30%), Positives = 71/142 (50%), Gaps = 4/142 (2%)
Query: 63 GGYDTTSCTLTYVLMNLGTYQDVQQKMYEE-IKNVFGDSERDVESDDLSKLVYTEAVIKE 121
G DTT+ L L L DVQQ + +E + SE ++ ++L A +KE
Sbjct: 314 GSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT--TELPLLRAALKE 371
Query: 122 SLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEP 181
+LRLYP+ + R + D+ + NY + AG + +Y + R+A +++ P+RWL+
Sbjct: 372 TLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDI 431
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G ++ FG G R C+G
Sbjct: 432 RGSGRNFH-HVPFGFGMRQCLG 452
>BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 78.6 bits (185), Expect = 5e-14
Identities = 52/172 (30%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+ G +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L+
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR+C G A + + +++ +++ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 72.1 bits (169), Expect = 4e-12
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + GG +T S TL Y + L + +V+ K++EEI V G R + +D +K+
Sbjct: 292 VMTTLNLFI-GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F +GKR C G
Sbjct: 410 DFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 441
>BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 78.6 bits (185), Expect = 5e-14
Identities = 52/172 (30%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+ G +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L+
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR+C G A + + +++ +++ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 72.1 bits (169), Expect = 4e-12
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + GG +T S TL Y + L + +V+ K++EEI V G R + +D +K+
Sbjct: 292 VMTTLNLFI-GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F +GKR C G
Sbjct: 410 DFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 441
>BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 78.6 bits (185), Expect = 5e-14
Identities = 52/172 (30%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+ G +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L+
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR+C G A + + +++ +++ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 72.1 bits (169), Expect = 4e-12
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + GG +T S TL Y + L + +V+ K++EEI V G R + +D +K+
Sbjct: 292 VMTTLNLFI-GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F +GKR C G
Sbjct: 410 DFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 441
>BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family 2,
subfamily A, polypeptide 6 protein.
Length = 494
Score = 78.6 bits (185), Expect = 5e-14
Identities = 52/172 (30%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+ G +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L+
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR+C G A + + +++ +++ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 72.1 bits (169), Expect = 4e-12
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + GG +T S TL Y + L + +V+ K++EEI V G R + +D +K+
Sbjct: 292 VMTTLNLFI-GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F +GKR C G
Sbjct: 410 DFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 441
>AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6
protein.
Length = 494
Score = 78.6 bits (185), Expect = 5e-14
Identities = 52/172 (30%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+ G +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L+
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR+C G A + + +++ +++ S D
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 72.1 bits (169), Expect = 4e-12
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + GG +T S TL Y + L + +V+ K++EEI V G R + +D +K+
Sbjct: 292 VMTTLNLFI-GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F +GKR C G
Sbjct: 410 DFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 441
>X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for
cytochrome P-450IIA. ).
Length = 489
Score = 78.2 bits (184), Expect = 6e-14
Identities = 52/172 (30%), Positives = 88/172 (51%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+ G +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 295 IGGTETVSTTLRYGFLLLMKHPEVEAQVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 353
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L+
Sbjct: 354 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 413
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR+C G A + + +++ +++ S D
Sbjct: 414 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 465
Score = 70.5 bits (165), Expect = 1e-11
Identities = 45/152 (29%), Positives = 75/152 (49%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + GG +T S TL Y + L + +V+ +++EEI V G + R + +D +K+
Sbjct: 287 VMTTLNLFI-GGTETVSTTLRYGFLLLMKHPEVEAQVHEEIDRVIGKN-RQPKFEDRAKM 344
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 345 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 404
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F +GKR C G
Sbjct: 405 DFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 436
>AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 428
Score = 78.2 bits (184), Expect = 6e-14
Identities = 47/150 (31%), Positives = 81/150 (54%), Gaps = 4/150 (2%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKN--VFGDSERD--VESDDLSKLVYTE 116
+FGG++TT+ T ++ LG Y V QK+ EE+K+ + S +D ++ + L +L Y
Sbjct: 229 LFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIG 288
Query: 117 AVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPE 176
VIKE+LRL P P FR + ++N Y + G ++ + A + ++F P+
Sbjct: 289 CVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPD 348
Query: 177 RWLEPDGVPSVYYAFATFGVGKRACIGTAF 206
R++ P + ++F FG G R+C+G F
Sbjct: 349 RFMLPHPEDASRFSFIPFGGGLRSCVGKEF 378
Score = 62.5 bits (145), Expect = 3e-09
Identities = 53/221 (23%), Positives = 96/221 (43%), Gaps = 10/221 (4%)
Query: 267 NKIIARKRSELASGVAA--ANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIMA 322
N I AR + + + A+E + L L+++ + E + L Q +++ +
Sbjct: 172 NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG 231
Query: 323 GFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD----VFGDSDRDLEKEDLSKLVYTEAVL 378
G +T++ ++ LG +P V + E+ + D L+ E L +L Y V+
Sbjct: 232 GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI 291
Query: 379 KETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL 438
KET+RL P R + +L + + G + S+ + + EF P+R++
Sbjct: 292 KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM 351
Query: 439 --DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
P+ +F F G RSC G+ +A L+KI L R
Sbjct: 352 LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR 392
>AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 497
Score = 78.2 bits (184), Expect = 6e-14
Identities = 47/150 (31%), Positives = 81/150 (54%), Gaps = 4/150 (2%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKN--VFGDSERD--VESDDLSKLVYTE 116
+FGG++TT+ T ++ LG Y V QK+ EE+K+ + S +D ++ + L +L Y
Sbjct: 298 LFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIG 357
Query: 117 AVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPE 176
VIKE+LRL P P FR + ++N Y + G ++ + A + ++F P+
Sbjct: 358 CVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPD 417
Query: 177 RWLEPDGVPSVYYAFATFGVGKRACIGTAF 206
R++ P + ++F FG G R+C+G F
Sbjct: 418 RFMLPHPEDASRFSFIPFGGGLRSCVGKEF 447
Score = 62.5 bits (145), Expect = 3e-09
Identities = 53/221 (23%), Positives = 96/221 (43%), Gaps = 10/221 (4%)
Query: 267 NKIIARKRSELASGVAA--ANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIMA 322
N I AR + + + A+E + L L+++ + E + L Q +++ +
Sbjct: 241 NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG 300
Query: 323 GFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD----VFGDSDRDLEKEDLSKLVYTEAVL 378
G +T++ ++ LG +P V + E+ + D L+ E L +L Y V+
Sbjct: 301 GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI 360
Query: 379 KETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL 438
KET+RL P R + +L + + G + S+ + + EF P+R++
Sbjct: 361 KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM 420
Query: 439 --DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
P+ +F F G RSC G+ +A L+KI L R
Sbjct: 421 LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR 461
>AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxylase
protein.
Length = 497
Score = 78.2 bits (184), Expect = 6e-14
Identities = 47/150 (31%), Positives = 81/150 (54%), Gaps = 4/150 (2%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKN--VFGDSERD--VESDDLSKLVYTE 116
+FGG++TT+ T ++ LG Y V QK+ EE+K+ + S +D ++ + L +L Y
Sbjct: 298 LFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIG 357
Query: 117 AVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPE 176
VIKE+LRL P P FR + ++N Y + G ++ + A + ++F P+
Sbjct: 358 CVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPD 417
Query: 177 RWLEPDGVPSVYYAFATFGVGKRACIGTAF 206
R++ P + ++F FG G R+C+G F
Sbjct: 418 RFMLPHPEDASRFSFIPFGGGLRSCVGKEF 447
Score = 62.5 bits (145), Expect = 3e-09
Identities = 53/221 (23%), Positives = 96/221 (43%), Gaps = 10/221 (4%)
Query: 267 NKIIARKRSELASGVAA--ANETDNKYQGLLDLMLKLAKE--DALTDQEIREEVDTAIMA 322
N I AR + + + A+E + L L+++ + E + L Q +++ +
Sbjct: 241 NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG 300
Query: 323 GFDTSSWILVYVLVNLGSFPEVQDRAYNEIMD----VFGDSDRDLEKEDLSKLVYTEAVL 378
G +T++ ++ LG +P V + E+ + D L+ E L +L Y V+
Sbjct: 301 GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI 360
Query: 379 KETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWL 438
KET+RL P R + +L + + G + S+ + + EF P+R++
Sbjct: 361 KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM 420
Query: 439 --DPQKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
P+ +F F G RSC G+ +A L+KI L R
Sbjct: 421 LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR 461
>X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein.
Length = 521
Score = 77.4 bits (182), Expect = 1e-13
Identities = 54/210 (25%), Positives = 99/210 (47%), Gaps = 6/210 (2%)
Query: 291 YQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYN 350
Y+G+L +L + ++ ++I+ V + G DT+S L + L + +VQD
Sbjct: 298 YRGIL---YRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRA 354
Query: 351 EIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGT 410
E++ + D+ L + +A +KET+RL+ + R++ D+ L+++ + A T
Sbjct: 355 EVLAARHQAQGDMATM-LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKT 413
Query: 411 DCSISLFGINRHTVWGEDVNEFKPERWLDPQK-IPDNAFAAFSIGKRSCTGRAYALTLMK 469
++++ + R + D F P RWL K I F G R C GR A M
Sbjct: 414 LVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMT 473
Query: 470 INLAHLLRKYKIS-GDVSKLDFKFNFIIKP 498
I L ++L +++ +S + FN I+ P
Sbjct: 474 IFLINMLENFRVEIQHLSDVGTTFNLILMP 503
Score = 70.1 bits (164), Expect = 2e-11
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
+I + + GG DTTS TL + L + VQ + E+ ++ D+ + L
Sbjct: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM-LQL 373
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ +A IKE+LRL+PI+ + R L D+ + +Y + A + +Y + R + D +
Sbjct: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P RWL D Y+ FG G R C+G
Sbjct: 434 NFDPTRWLSKD-KNITYFRNLGFGWGVRQCLG 464
>M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc
protein.
Length = 239
Score = 77.4 bits (182), Expect = 1e-13
Identities = 54/210 (25%), Positives = 99/210 (47%), Gaps = 6/210 (2%)
Query: 291 YQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYN 350
Y+G+L +L + ++ ++I+ V + G DT+S L + L + +VQD
Sbjct: 16 YRGML---YRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRA 72
Query: 351 EIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGT 410
E++ + D+ L + +A +KET+RL+ + R++ D+ L+++ + A T
Sbjct: 73 EVLAARHQAQGDMATM-LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKT 131
Query: 411 DCSISLFGINRHTVWGEDVNEFKPERWLDPQK-IPDNAFAAFSIGKRSCTGRAYALTLMK 469
++++ + R + D F P RWL K I F G R C GR A M
Sbjct: 132 LVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMT 191
Query: 470 INLAHLLRKYKIS-GDVSKLDFKFNFIIKP 498
I L ++L +++ +S + FN I+ P
Sbjct: 192 IFLINMLENFRVEIQHLSDVGTTFNLILMP 221
Score = 70.1 bits (164), Expect = 2e-11
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
+I + + GG DTTS TL + L + VQ + E+ ++ D+ + L
Sbjct: 33 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM-LQL 91
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ +A IKE+LRL+PI+ + R L D+ + +Y + A + +Y + R + D +
Sbjct: 92 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 151
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P RWL D Y+ FG G R C+G
Sbjct: 152 NFDPTRWLSKD-KNITYFRNLGFGWGVRQCLG 182
>M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein.
Length = 521
Score = 77.4 bits (182), Expect = 1e-13
Identities = 54/210 (25%), Positives = 99/210 (47%), Gaps = 6/210 (2%)
Query: 291 YQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYN 350
Y+G+L +L + ++ ++I+ V + G DT+S L + L + +VQD
Sbjct: 298 YRGML---YRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRA 354
Query: 351 EIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGT 410
E++ + D+ L + +A +KET+RL+ + R++ D+ L+++ + A T
Sbjct: 355 EVLAARHQAQGDMATM-LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKT 413
Query: 411 DCSISLFGINRHTVWGEDVNEFKPERWLDPQK-IPDNAFAAFSIGKRSCTGRAYALTLMK 469
++++ + R + D F P RWL K I F G R C GR A M
Sbjct: 414 LVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMT 473
Query: 470 INLAHLLRKYKIS-GDVSKLDFKFNFIIKP 498
I L ++L +++ +S + FN I+ P
Sbjct: 474 IFLINMLENFRVEIQHLSDVGTTFNLILMP 503
Score = 70.1 bits (164), Expect = 2e-11
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
+I + + GG DTTS TL + L + VQ + E+ ++ D+ + L
Sbjct: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM-LQL 373
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ +A IKE+LRL+PI+ + R L D+ + +Y + A + +Y + R + D +
Sbjct: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P RWL D Y+ FG G R C+G
Sbjct: 434 NFDPTRWLSKD-KNITYFRNLGFGWGVRQCLG 464
>BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family
11, subfamily A, polypeptide 1 protein.
Length = 521
Score = 77.4 bits (182), Expect = 1e-13
Identities = 54/210 (25%), Positives = 99/210 (47%), Gaps = 6/210 (2%)
Query: 291 YQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYN 350
Y+G+L +L + ++ ++I+ V + G DT+S L + L + +VQD
Sbjct: 298 YRGIL---YRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRA 354
Query: 351 EIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGT 410
E++ + D+ L + +A +KET+RL+ + R++ D+ L+++ + A T
Sbjct: 355 EVLAARHQAQGDMATM-LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKT 413
Query: 411 DCSISLFGINRHTVWGEDVNEFKPERWLDPQK-IPDNAFAAFSIGKRSCTGRAYALTLMK 469
++++ + R + D F P RWL K I F G R C GR A M
Sbjct: 414 LVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMT 473
Query: 470 INLAHLLRKYKIS-GDVSKLDFKFNFIIKP 498
I L ++L +++ +S + FN I+ P
Sbjct: 474 IFLINMLENFRVEIQHLSDVGTTFNLILMP 503
Score = 70.1 bits (164), Expect = 2e-11
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 52 EILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSK 111
+I + + GG DTTS TL + L + VQ + E+ ++ D+ + L
Sbjct: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM-LQL 373
Query: 112 LVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
+ +A IKE+LRL+PI+ + R L D+ + +Y + A + +Y + R + D +
Sbjct: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P RWL D Y+ FG G R C+G
Sbjct: 434 NFDPTRWLSKD-KNITYFRNLGFGWGVRQCLG 464
>U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450
monooxygenase CYP2J2 protein.
Length = 502
Score = 76.6 bits (180), Expect = 2e-13
Identities = 47/143 (32%), Positives = 72/143 (50%), Gaps = 3/143 (2%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +TTS TL + L+ + Y ++Q+K+ EI V G ++ + + YT AVI E
Sbjct: 310 FAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHE 368
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R+ I P+ + RE+ D + Y L G N+ ++R D F P+ +LE
Sbjct: 369 VQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE 428
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
+G AF F +GKRAC+G
Sbjct: 429 -NGQFKKREAFMPFSIGKRACLG 450
Score = 74.9 bits (176), Expect = 6e-13
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 6/184 (3%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T+S L + L+ + +PE+Q++ EI V G + S + YT AV+ E
Sbjct: 311 AGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARES-MPYTNAVIHEV 369
Query: 382 MRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R+ + P+++ R + D L + L GT +L ++R + F P+ +L+
Sbjct: 370 QRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN 429
Query: 441 QKIPDN-AFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI---SGDVSKLDFKFNFII 496
+ AF FSIGKR+C G A T + I L++K+ + + L F+ I
Sbjct: 430 GQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITI 489
Query: 497 KPIS 500
P+S
Sbjct: 490 SPVS 493
>U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 76.6 bits (180), Expect = 2e-13
Identities = 54/171 (31%), Positives = 83/171 (48%), Gaps = 4/171 (2%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ YTEAV+ E
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHEI 359
Query: 382 MRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R M P+ L H + +D K ++F L GT+ L R + + + P+ +LD
Sbjct: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSELRDPRFFSNPQDCSPQHFLDE 419
Query: 441 --QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSIGKR C G A + + +++ ++ S D
Sbjct: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKD 470
Score = 66.5 bits (155), Expect = 2e-10
Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 2/143 (1%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +T S TL Y + L + +V+ K++EEI V G R + +D +K+ YTEAVI E
Sbjct: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYTEAVIHE 358
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R + P+ + +++D K ++ L G + R + + P+ +L+
Sbjct: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSELRDPRFFSNPQDCSPQHFLD 418
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
G AF F +GKR C G
Sbjct: 419 EKGQFKKSDAFVPFSIGKRYCFG 441
>BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 76.6 bits (180), Expect = 2e-13
Identities = 47/143 (32%), Positives = 72/143 (50%), Gaps = 3/143 (2%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +TTS TL + L+ + Y ++Q+K+ EI V G ++ + + YT AVI E
Sbjct: 310 FAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHE 368
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R+ I P+ + RE+ D + Y L G N+ ++R D F P+ +LE
Sbjct: 369 VQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE 428
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
+G AF F +GKRAC+G
Sbjct: 429 -NGQFKKREAFMPFSIGKRACLG 450
Score = 74.9 bits (176), Expect = 6e-13
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 6/184 (3%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T+S L + L+ + +PE+Q++ EI V G + S + YT AV+ E
Sbjct: 311 AGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARES-MPYTNAVIHEV 369
Query: 382 MRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R+ + P+++ R + D L + L GT +L ++R + F P+ +L+
Sbjct: 370 QRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN 429
Query: 441 QKIPDN-AFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI---SGDVSKLDFKFNFII 496
+ AF FSIGKR+C G A T + I L++K+ + + L F+ I
Sbjct: 430 GQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITI 489
Query: 497 KPIS 500
P+S
Sbjct: 490 SPVS 493
>BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family 2,
subfamily W, polypeptide 1 protein.
Length = 490
Score = 76.6 bits (180), Expect = 2e-13
Identities = 53/164 (32%), Positives = 75/164 (45%), Gaps = 3/164 (1%)
Query: 320 IMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLK 379
+MAG +T+S L + + +G P+VQ R E+ V G R ED L YT AVL
Sbjct: 294 VMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPG-RTPRLEDQQALPYTSAVLH 352
Query: 380 ETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
E R T+ P R D +L F L GT L + + +F P +LD
Sbjct: 353 EVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLD 412
Query: 440 PQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI 481
+ AF FS G+R C G A T + + A LL++Y++
Sbjct: 413 ANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRL 456
Score = 63.3 bits (147), Expect = 2e-09
Identities = 40/143 (27%), Positives = 63/143 (44%), Gaps = 1/143 (0%)
Query: 61 VFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIK 120
V G +TTS TL + + +G + DVQ ++ EE+ V G R +D L YT AV+
Sbjct: 294 VMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPG-RTPRLEDQQALPYTSAVLH 352
Query: 121 ESLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
E R + P + R D ++ + L G + + +F P +L+
Sbjct: 353 EVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLD 412
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
+G AF F G+R C+G
Sbjct: 413 ANGHFVKREAFLPFSAGRRVCVG 435
>AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 76.6 bits (180), Expect = 2e-13
Identities = 47/143 (32%), Positives = 72/143 (50%), Gaps = 3/143 (2%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +TTS TL + L+ + Y ++Q+K+ EI V G ++ + + YT AVI E
Sbjct: 310 FAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHE 368
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R+ I P+ + RE+ D + Y L G N+ ++R D F P+ +LE
Sbjct: 369 VQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE 428
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
+G AF F +GKRAC+G
Sbjct: 429 -NGQFKKREAFMPFSIGKRACLG 450
Score = 74.9 bits (176), Expect = 6e-13
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 6/184 (3%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T+S L + L+ + +PE+Q++ EI V G + S + YT AV+ E
Sbjct: 311 AGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARES-MPYTNAVIHEV 369
Query: 382 MRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R+ + P+++ R + D L + L GT +L ++R + F P+ +L+
Sbjct: 370 QRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN 429
Query: 441 QKIPDN-AFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI---SGDVSKLDFKFNFII 496
+ AF FSIGKR+C G A T + I L++K+ + + L F+ I
Sbjct: 430 GQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITI 489
Query: 497 KPIS 500
P+S
Sbjct: 490 SPVS 493
>AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein.
Length = 502
Score = 76.6 bits (180), Expect = 2e-13
Identities = 47/143 (32%), Positives = 72/143 (50%), Gaps = 3/143 (2%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +TTS TL + L+ + Y ++Q+K+ EI V G ++ + + YT AVI E
Sbjct: 310 FAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHE 368
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R+ I P+ + RE+ D + Y L G N+ ++R D F P+ +LE
Sbjct: 369 VQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE 428
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
+G AF F +GKRAC+G
Sbjct: 429 -NGQFKKREAFMPFSIGKRACLG 450
Score = 74.9 bits (176), Expect = 6e-13
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 6/184 (3%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T+S L + L+ + +PE+Q++ EI V G + S + YT AV+ E
Sbjct: 311 AGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARES-MPYTNAVIHEV 369
Query: 382 MRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R+ + P+++ R + D L + L GT +L ++R + F P+ +L+
Sbjct: 370 QRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN 429
Query: 441 QKIPDN-AFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI---SGDVSKLDFKFNFII 496
+ AF FSIGKR+C G A T + I L++K+ + + L F+ I
Sbjct: 430 GQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITI 489
Query: 497 KPIS 500
P+S
Sbjct: 490 SPVS 493
>X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (11 Beta). ).
Length = 503
Score = 76.2 bits (179), Expect = 3e-13
Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 5/177 (2%)
Query: 325 DTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRL 384
DT+ + L+ L L P VQ E + +K ++L A LKET+RL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 385 YTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIP 444
Y +G R + D+ L+N+ + AGT + L+ + R+ + P+RWLD +
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSG 435
Query: 445 DNAF-AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFK--FNFIIKP 498
N + F G R C GR A M + L H+L+ ++ +++ D K ++FI++P
Sbjct: 436 RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE-TLTQEDIKMVYSFILRP 491
Score = 68.9 bits (161), Expect = 4e-11
Identities = 42/142 (29%), Positives = 69/142 (48%), Gaps = 4/142 (2%)
Query: 63 GGYDTTSCTLTYVLMNLGTYQDVQQKMYEE-IKNVFGDSERDVESDDLSKLVYTEAVIKE 121
G DTT L L L +VQQ + +E + SE ++ ++L A +KE
Sbjct: 314 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT--TELPLLRAALKE 371
Query: 122 SLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEP 181
+LRLYP+ + R + D+ + NY + AG + +Y + R+ +++ P+RWL+
Sbjct: 372 TLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G +Y FG G R C+G
Sbjct: 432 RGSGRNFY-HVPFGFGMRQCLG 452
>DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6
protein.
Length = 500
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 290 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 348
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 349 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 408
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 409 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 468
Query: 481 IS 482
S
Sbjct: 469 FS 470
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 309 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 367
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 368 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 426
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 427 QGHFVKPEAFLPFSAGRRACLG 448
>DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein.
Length = 446
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 236 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 294
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 295 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 354
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 355 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 414
Query: 481 IS 482
S
Sbjct: 415 FS 416
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 255 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 313
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 314 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 372
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 373 QGHFVKPEAFLPFSAGRRACLG 394
>BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 446
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 236 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 294
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 295 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 354
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 355 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 414
Query: 481 IS 482
S
Sbjct: 415 FS 416
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 255 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 313
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 314 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 372
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 373 QGHFVKPEAFLPFSAGRRACLG 394
>BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein.
Length = 446
Score = 76.2 bits (179), Expect = 3e-13
Identities = 53/182 (29%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI DV G R
Sbjct: 236 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP- 294
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 295 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 354
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 355 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 414
Query: 481 IS 482
S
Sbjct: 415 FS 416
Score = 69.7 bits (163), Expect = 2e-11
Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI +V G R E D + + YT AVI E
Sbjct: 255 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 313
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 314 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 372
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 373 QGHFVKPEAFLPFSAGRRACLG 394
>AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2
protein.
Length = 502
Score = 76.2 bits (179), Expect = 3e-13
Identities = 47/143 (32%), Positives = 72/143 (50%), Gaps = 3/143 (2%)
Query: 62 FGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKE 121
F G +TTS TL + L+ + Y ++Q+K+ EI V G ++ + + YT AVI E
Sbjct: 310 FAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQP-STAARESMPYTNAVIHE 368
Query: 122 SLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLE 180
R+ I P+ + RE+ D + Y L G N+ ++R D F P+ +LE
Sbjct: 369 VQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE 428
Query: 181 PDGVPSVYYAFATFGVGKRACIG 203
+G AF F +GKRAC+G
Sbjct: 429 -NGQFKKREAFMPFSIGKRACLG 450
Score = 74.5 bits (175), Expect = 8e-13
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 6/184 (3%)
Query: 322 AGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKET 381
AG +T+S L + L+ + +PE+Q++ EI V G + S + YT AV+ E
Sbjct: 311 AGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQPSTAARES-MPYTNAVIHEV 369
Query: 382 MRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP 440
R+ + P+++ R + D L + L GT +L ++R + F P+ +L+
Sbjct: 370 QRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN 429
Query: 441 QKIPDN-AFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKI---SGDVSKLDFKFNFII 496
+ AF FSIGKR+C G A T + I L++K+ + + L F+ I
Sbjct: 430 GQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITI 489
Query: 497 KPIS 500
P+S
Sbjct: 490 SPVS 493
>BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 2 protein.
Length = 516
Score = 75.8 bits (178), Expect = 3e-13
Identities = 50/157 (31%), Positives = 77/157 (49%), Gaps = 6/157 (3%)
Query: 52 EILEELNTAVFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLS 110
E + L +FG G+DT + +++ LM L T ++Q+K+ +E+ V G ER D
Sbjct: 305 EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RERRPRLSDRP 363
Query: 111 KLVYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+L Y EA I E+ R P P I +D +N + + +N + +N +D
Sbjct: 364 QLPYLEAFILETFRHSPFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423
Query: 170 ADKFRPERWLEPDGV---PSVYYAFATFGVGKRACIG 203
+FRPER+L DG + FG+GKR CIG
Sbjct: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIG 460
Score = 64.1 bits (149), Expect = 1e-09
Identities = 52/187 (27%), Positives = 84/187 (44%), Gaps = 7/187 (3%)
Query: 302 AKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDR 361
A + + ++I V+ AGFDT + + + L+ L + PE+Q + E+ V G +R
Sbjct: 297 ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RER 355
Query: 362 DLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGIN 420
D +L Y EA + ET R P ++ H D L F + ++ + +N
Sbjct: 356 RPRLSDRPQLPYLEAFILETFRHSPFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415
Query: 421 RHTVWGEDVNEFKPERWLDP-----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHL 475
ED +EF+PER+L K F +GKR C G A + + LA L
Sbjct: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAIL 475
Query: 476 LRKYKIS 482
L++ + S
Sbjct: 476 LQQLEFS 482
>U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 74.9 bits (176), Expect = 6e-13
Identities = 52/172 (30%), Positives = 87/172 (50%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRTKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L GT+ L + R + + +F P+ +L
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDLRFFSNPRDFNPQHFLG 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSI KR+C G A + + +++ +++ S D
Sbjct: 419 EKGQFKKRDAFVPFSIRKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 64.5 bits (150), Expect = 8e-10
Identities = 44/152 (28%), Positives = 73/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + G +T S TL Y + L + +V+ K++EEI V G + R + +D +K+
Sbjct: 292 MMSTLNLFI-AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKN-RQPKFEDRTKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDLRFFSNPR 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F + KR C G
Sbjct: 410 DFNPQHFLGEKGQFKKRDAFVPFSIRKRNCFG 441
>DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 74.9 bits (176), Expect = 6e-13
Identities = 52/182 (28%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI D+ G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDMIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 68.5 bits (160), Expect = 5e-11
Identities = 43/142 (30%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI ++ G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDMIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome
P-450c11 protein protein.
Length = 503
Score = 74.9 bits (176), Expect = 6e-13
Identities = 55/210 (26%), Positives = 93/210 (44%), Gaps = 5/210 (2%)
Query: 292 QGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNE 351
Q ++ +L L+ I+ DT+ + L+ L L P VQ E
Sbjct: 284 QQYTSIVAELLLNAELSPDAIKANSMELTAGSMDTTVFPLLMTLFELARNPNVQQALRQE 343
Query: 352 IMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKLKNFTLKAGTD 411
+ +K ++L A LKET+RLY +G R D+ L+N+ + AGT
Sbjct: 344 SLAAAASISEHPQKAT-TELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTL 402
Query: 412 CSISLFGINRHTVWGEDVNEFKPERWLDPQKIPDNAF-AAFSIGKRSCTGRAYALTLMKI 470
+ L+ + R+ + P+RWLD + N + F G R C GR A M +
Sbjct: 403 VRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLL 462
Query: 471 NLAHLLRKYKISGDVSKLDFK--FNFIIKP 498
L H+L+ ++ +++ D K ++FI++P
Sbjct: 463 LLHHVLKHLQVE-TLTQEDIKMVYSFILRP 491
Score = 68.1 bits (159), Expect = 7e-11
Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 63 GGYDTTSCTLTYVLMNLGTYQDVQQKMYEE-IKNVFGDSERDVESDDLSKLVYTEAVIKE 121
G DTT L L L +VQQ + +E + SE ++ ++L A +KE
Sbjct: 314 GSMDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT--TELPLLRAALKE 371
Query: 122 SLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEP 181
+LRLYP+ + R D+ + NY + AG + +Y + R+ +++ P+RWL+
Sbjct: 372 TLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G +Y FG G R C+G
Sbjct: 432 RGSGRNFY-HVPFGFGMRQCLG 452
>X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein.
Length = 512
Score = 74.5 bits (175), Expect = 8e-13
Identities = 60/185 (32%), Positives = 88/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 357
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R ++ P ++ H D LK F + G ++ + IN
Sbjct: 358 -RLSDRSHLPYMEAFILETFRHSSLVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 416
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 417 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQ 476
Query: 478 KYKIS 482
+ + S
Sbjct: 477 RVEFS 481
Score = 74.1 bits (174), Expect = 1e-12
Identities = 50/147 (34%), Positives = 72/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 372
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R + P I +D + + + GR +N + IN + +F PER+
Sbjct: 373 LETFRHSSLVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIG 459
>M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein.
Length = 503
Score = 74.5 bits (175), Expect = 8e-13
Identities = 51/177 (28%), Positives = 84/177 (47%), Gaps = 5/177 (2%)
Query: 325 DTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRL 384
DT+ + L+ L L P VQ E + +K ++L A LKET+RL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 385 YTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIP 444
Y +G R D+ L+N+ + AGT + L+ + R+ + P+RWLD +
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSG 435
Query: 445 DNAF-AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFK--FNFIIKP 498
N + F G R C GR A M + L H+L+ ++ +++ D K ++FI++P
Sbjct: 436 RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE-TLTQEDIKMVYSFILRP 491
Score = 68.1 bits (159), Expect = 7e-11
Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 63 GGYDTTSCTLTYVLMNLGTYQDVQQKMYEE-IKNVFGDSERDVESDDLSKLVYTEAVIKE 121
G DTT L L L +VQQ + +E + SE ++ ++L A +KE
Sbjct: 314 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT--TELPLLRAALKE 371
Query: 122 SLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEP 181
+LRLYP+ + R D+ + NY + AG + +Y + R+ +++ P+RWL+
Sbjct: 372 TLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G +Y FG G R C+G
Sbjct: 432 RGSGRNFY-HVPFGFGMRQCLG 452
>BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 74.5 bits (175), Expect = 8e-13
Identities = 52/182 (28%), Positives = 84/182 (46%), Gaps = 4/182 (2%)
Query: 304 EDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDL 363
E + D+ + V AG T+S L + L+ + P+VQ R EI +V G R
Sbjct: 287 ESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDEVIGQVRRP- 345
Query: 364 EKEDLSKLVYTEAVLKETMRLYTMGPVSLRHI-EEDVKLKNFTLKAGTDCSISLFGINRH 422
E D + + YT AV+ E R + P+ + H+ D++++ F + GT +L + +
Sbjct: 346 EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKD 405
Query: 423 TVWGEDVNEFKPERWLDPQK--IPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYK 480
E F PE +LD Q + AF FS G+R+C G A + + LL+ +
Sbjct: 406 EAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 465
Query: 481 IS 482
S
Sbjct: 466 FS 467
Score = 69.3 bits (162), Expect = 3e-11
Identities = 44/142 (30%), Positives = 72/142 (50%), Gaps = 4/142 (2%)
Query: 64 GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVIKESL 123
G TTS TL + L+ + + DVQ+++ +EI V G R E D + + YT AVI E
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDEVIGQVRRP-EMGDQAHMPYTTAVIHEVQ 364
Query: 124 RLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINR-HAMWGDDADKFRPERWLEP 181
R I P+ + +D+++ + + G N+ + + A+W + +F PE +L+
Sbjct: 365 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDA 423
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G AF F G+RAC+G
Sbjct: 424 QGHFVKPEAFLPFSAGRRACLG 445
>BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family
11, subfamily B, polypeptide 1 protein.
Length = 503
Score = 74.5 bits (175), Expect = 8e-13
Identities = 51/177 (28%), Positives = 84/177 (47%), Gaps = 5/177 (2%)
Query: 325 DTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRL 384
DT+ + L+ L L P VQ E + +K ++L A LKET+RL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 385 YTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIP 444
Y +G R D+ L+N+ + AGT + L+ + R+ + P+RWLD +
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSG 435
Query: 445 DNAF-AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFK--FNFIIKP 498
N + F G R C GR A M + L H+L+ ++ +++ D K ++FI++P
Sbjct: 436 RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE-TLTQEDIKMVYSFILRP 491
Score = 68.1 bits (159), Expect = 7e-11
Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 63 GGYDTTSCTLTYVLMNLGTYQDVQQKMYEE-IKNVFGDSERDVESDDLSKLVYTEAVIKE 121
G DTT L L L +VQQ + +E + SE ++ ++L A +KE
Sbjct: 314 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT--TELPLLRAALKE 371
Query: 122 SLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEP 181
+LRLYP+ + R D+ + NY + AG + +Y + R+ +++ P+RWL+
Sbjct: 372 TLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G +Y FG G R C+G
Sbjct: 432 RGSGRNFY-HVPFGFGMRQCLG 452
>BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein.
Length = 574
Score = 74.5 bits (175), Expect = 8e-13
Identities = 51/177 (28%), Positives = 84/177 (47%), Gaps = 5/177 (2%)
Query: 325 DTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRL 384
DT+ + L+ L L P VQ E + +K ++L A LKET+RL
Sbjct: 388 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 446
Query: 385 YTMGPVSLRHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDPQKIP 444
Y +G R D+ L+N+ + AGT + L+ + R+ + P+RWLD +
Sbjct: 447 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSG 506
Query: 445 DNAF-AAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLDFK--FNFIIKP 498
N + F G R C GR A M + L H+L+ ++ +++ D K ++FI++P
Sbjct: 507 RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE-TLTQEDIKMVYSFILRP 562
Score = 68.1 bits (159), Expect = 7e-11
Identities = 42/142 (29%), Positives = 68/142 (47%), Gaps = 4/142 (2%)
Query: 63 GGYDTTSCTLTYVLMNLGTYQDVQQKMYEE-IKNVFGDSERDVESDDLSKLVYTEAVIKE 121
G DTT L L L +VQQ + +E + SE ++ ++L A +KE
Sbjct: 385 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT--TELPLLRAALKE 442
Query: 122 SLRLYPIAPIIFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERWLEP 181
+LRLYP+ + R D+ + NY + AG + +Y + R+ +++ P+RWL+
Sbjct: 443 TLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 502
Query: 182 DGVPSVYYAFATFGVGKRACIG 203
G +Y FG G R C+G
Sbjct: 503 RGSGRNFY-HVPFGFGMRQCLG 523
>X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein.
Length = 141
Score = 73.7 bits (173), Expect = 1e-12
Identities = 46/144 (31%), Positives = 74/144 (51%), Gaps = 4/144 (2%)
Query: 59 TAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAV 118
T +F G+DTT+ ++++L L T+ Q++ EEI + GD + + L ++ YT
Sbjct: 1 TFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMC 59
Query: 119 IKESLRLYPIAPIIFRELDQDVKI-NNYTLKAGRGCAINVYGINRHAMWGDDADKFRPER 177
IKE+LRLYP P I REL V + +L G +++YG++ + + + F P R
Sbjct: 60 IKEALRLYPPVPGISRELSTPVTFPDGRSLPKGITVMLSIYGLHHNPKVWPNPEVFDPSR 119
Query: 178 WLEPDGVPSVYYAFATFGVGKRAC 201
+ G +AF F G R C
Sbjct: 120 F--APGSAQHSHAFLPFSGGSRNC 141
Score = 57.6 bits (133), Expect = 1e-07
Identities = 38/142 (26%), Positives = 66/142 (46%), Gaps = 2/142 (1%)
Query: 318 TAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAV 377
T + G DT++ + ++L L + P+ Q+R EI + GD + L ++ YT
Sbjct: 1 TFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMC 59
Query: 378 LKETMRLYTMGPVSLRHIEEDVKLKN-FTLKAGTDCSISLFGINRHTVWGEDVNEFKPER 436
+KE +RLY P R + V + +L G +S++G++ + + F P R
Sbjct: 60 IKEALRLYPPVPGISRELSTPVTFPDGRSLPKGITVMLSIYGLHHNPKVWPNPEVFDPSR 119
Query: 437 WLDPQKIPDNAFAAFSIGKRSC 458
+ +AF FS G R+C
Sbjct: 120 FAPGSAQHSHAFLPFSGGSRNC 141
>X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein.
Length = 512
Score = 73.7 bits (173), Expect = 1e-12
Identities = 60/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 357
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + IN
Sbjct: 358 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 416
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 417 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476
Query: 478 KYKIS 482
+ + S
Sbjct: 477 RVEFS 481
Score = 73.3 bits (172), Expect = 2e-12
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 372
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + IN + +F PER+
Sbjct: 373 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIG 459
>M12079-1|AAA52152.1| 191|Homo sapiens POR protein.
Length = 191
Score = 73.7 bits (173), Expect = 1e-12
Identities = 60/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 8 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 63
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + IN
Sbjct: 64 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 122
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 123 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQ 182
Query: 478 KYKIS 482
+ + S
Sbjct: 183 RVEFS 187
Score = 73.3 bits (172), Expect = 2e-12
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 20 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 78
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + IN + +F PER+
Sbjct: 79 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 138
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 139 LTPDGAIDKVLSEKVIIFGMGKRKCIG 165
>K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein.
Length = 512
Score = 73.7 bits (173), Expect = 1e-12
Identities = 60/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 357
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + IN
Sbjct: 358 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 416
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 417 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQ 476
Query: 478 KYKIS 482
+ + S
Sbjct: 477 RVEFS 481
Score = 73.3 bits (172), Expect = 2e-12
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 372
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + IN + +F PER+
Sbjct: 373 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIG 459
>EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 73.7 bits (173), Expect = 1e-12
Identities = 60/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 357
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + IN
Sbjct: 358 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 416
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 417 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476
Query: 478 KYKIS 482
+ + S
Sbjct: 477 RVEFS 481
Score = 73.3 bits (172), Expect = 2e-12
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 372
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + IN + +F PER+
Sbjct: 373 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIG 459
>BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 protein.
Length = 512
Score = 73.7 bits (173), Expect = 1e-12
Identities = 60/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 357
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + IN
Sbjct: 358 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 416
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 417 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476
Query: 478 KYKIS 482
+ + S
Sbjct: 477 RVEFS 481
Score = 73.3 bits (172), Expect = 2e-12
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 372
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + IN + +F PER+
Sbjct: 373 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIG 459
>AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1
variant protein.
Length = 484
Score = 73.7 bits (173), Expect = 1e-12
Identities = 60/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 274 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 329
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + IN
Sbjct: 330 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 388
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 389 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 448
Query: 478 KYKIS 482
+ + S
Sbjct: 449 RVEFS 453
Score = 73.3 bits (172), Expect = 2e-12
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 286 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 344
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + IN + +F PER+
Sbjct: 345 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 404
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 405 LTPDGAIDKVLSEKVIIFGMGKRKCIG 431
>AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1
protein.
Length = 251
Score = 73.7 bits (173), Expect = 1e-12
Identities = 60/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 41 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 96
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + IN
Sbjct: 97 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 155
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 156 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 215
Query: 478 KYKIS 482
+ + S
Sbjct: 216 RVEFS 220
Score = 73.3 bits (172), Expect = 2e-12
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 53 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 111
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + IN + +F PER+
Sbjct: 112 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 171
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 172 LTPDGAIDKVLSEKVIIFGMGKRKCIG 198
>AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 73.7 bits (173), Expect = 1e-12
Identities = 60/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 357
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + IN
Sbjct: 358 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 416
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 417 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476
Query: 478 KYKIS 482
+ + S
Sbjct: 477 RVEFS 481
Score = 73.3 bits (172), Expect = 2e-12
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 372
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + IN + +F PER+
Sbjct: 373 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIG 459
>AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein.
Length = 512
Score = 73.7 bits (173), Expect = 1e-12
Identities = 60/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDTS----SWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT SW L+Y+++N P VQ + E+ V G S R
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 357
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + IN
Sbjct: 358 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 416
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 417 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476
Query: 478 KYKIS 482
+ + S
Sbjct: 477 RVEFS 481
Score = 73.3 bits (172), Expect = 2e-12
Identities = 50/147 (34%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + +++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 372
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + IN + +F PER+
Sbjct: 373 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIG 459
>AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family 1,
subfamily A, polypeptide 1 variant protein.
Length = 512
Score = 72.9 bits (171), Expect = 2e-12
Identities = 59/185 (31%), Positives = 88/185 (47%), Gaps = 14/185 (7%)
Query: 307 LTDQEIREEVDTAIMAGFDT----SSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRD 362
L+D++I V AGFDT +SW L+Y+++N P VQ + E+ V G S R
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTATSWSLMYLVMN----PRVQRKIQEELDTVIGRSRRP 357
Query: 363 LEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGINR 421
D S L Y EA + ET R + P ++ H D LK F + G ++ + I+
Sbjct: 358 -RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIDH 416
Query: 422 HTVWGEDVNEFKPERWLDP----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLR 477
+ +EF PER+L P K+ F +GKR C G A + + LA LL+
Sbjct: 417 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476
Query: 478 KYKIS 482
+ + S
Sbjct: 477 RVEFS 481
Score = 70.1 bits (164), Expect = 2e-11
Identities = 49/147 (33%), Positives = 70/147 (47%), Gaps = 5/147 (3%)
Query: 61 VFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKLVYTEAVI 119
+FG G+DT + ++ LM L VQ+K+ EE+ V G S R D S L Y EA I
Sbjct: 314 LFGAGFDTVTTATSWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFI 372
Query: 120 KESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDADKFRPERW 178
E+ R P I +D + + + GR +N + I+ + +F PER+
Sbjct: 373 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIDHDQKLWVNPSEFLPERF 432
Query: 179 LEPDGVPSVYYA--FATFGVGKRACIG 203
L PDG + FG+GKR CIG
Sbjct: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIG 459
>AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2
protein.
Length = 516
Score = 72.9 bits (171), Expect = 2e-12
Identities = 50/157 (31%), Positives = 76/157 (48%), Gaps = 6/157 (3%)
Query: 52 EILEELNTAVFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLS 110
E + L VFG G+DT + +++ LM L T ++Q+K+ +E+ V G ER D
Sbjct: 305 EKIVNLVNDVFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RERRPRLSDRP 363
Query: 111 KLVYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+L Y EA I E+ R P I +D +N + + +N + +N +D
Sbjct: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423
Query: 170 ADKFRPERWLEPDGV---PSVYYAFATFGVGKRACIG 203
+FRPER+L DG + FG+GKR CIG
Sbjct: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIG 460
Score = 65.3 bits (152), Expect = 5e-10
Identities = 52/187 (27%), Positives = 85/187 (45%), Gaps = 7/187 (3%)
Query: 302 AKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDR 361
A + + ++I V+ AGFDT + + + L+ L + PE+Q + E+ V G +R
Sbjct: 297 ASGNLIPQEKIVNLVNDVFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RER 355
Query: 362 DLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGIN 420
D +L Y EA + ET R + P ++ H D L F + ++ + +N
Sbjct: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415
Query: 421 RHTVWGEDVNEFKPERWLDP-----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHL 475
ED +EF+PER+L K F +GKR C G A + + LA L
Sbjct: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAIL 475
Query: 476 LRKYKIS 482
L++ + S
Sbjct: 476 LQQLEFS 482
>Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for
cytochrome P-3-450. ).
Length = 515
Score = 72.5 bits (170), Expect = 3e-12
Identities = 49/157 (31%), Positives = 76/157 (48%), Gaps = 6/157 (3%)
Query: 52 EILEELNTAVFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLS 110
E + L +FG G+DT + +++ LM L T ++Q+K+ +E+ V G ER D
Sbjct: 305 EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RERRPRLSDRP 363
Query: 111 KLVYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+L Y EA I E+ R P I +D +N + + +N + +N +D
Sbjct: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423
Query: 170 ADKFRPERWLEPDGV---PSVYYAFATFGVGKRACIG 203
+FRPER+L DG + FG+GKR CIG
Sbjct: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIG 460
Score = 64.9 bits (151), Expect = 6e-10
Identities = 52/187 (27%), Positives = 85/187 (45%), Gaps = 7/187 (3%)
Query: 302 AKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDR 361
A + + ++I V+ AGFDT + + + L+ L + PE+Q + E+ V G +R
Sbjct: 297 ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RER 355
Query: 362 DLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGIN 420
D +L Y EA + ET R + P ++ H D L F + ++ + +N
Sbjct: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415
Query: 421 RHTVWGEDVNEFKPERWLDP-----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHL 475
ED +EF+PER+L K F +GKR C G A + + LA L
Sbjct: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAIL 475
Query: 476 LRKYKIS 482
L++ + S
Sbjct: 476 LQQLEFS 482
>U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein.
Length = 494
Score = 72.5 bits (170), Expect = 3e-12
Identities = 51/172 (29%), Positives = 86/172 (50%), Gaps = 4/172 (2%)
Query: 321 MAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKE 380
+AG +T S L Y + L PEV+ + + EI V G +R + ED +K+ Y EAV+ E
Sbjct: 300 IAGTETVSTTLHYGFLLLMKHPEVEAKVHEEIDRVIG-KNRQPKFEDRAKMPYMEAVIHE 358
Query: 381 TMRLYTMGPVSL-RHIEEDVKLKNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD 439
R + P+SL R +++D K ++F L G + L + R + + +F P+ +L
Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGIEVFPMLGSVLRDLRFFSNPRDFNPQHFLG 418
Query: 440 P--QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHLLRKYKISGDVSKLD 489
Q +AF FSI KR+C G A + + +++ +++ S D
Sbjct: 419 EKGQFKKRDAFVPFSIRKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKD 470
Score = 63.3 bits (147), Expect = 2e-09
Identities = 44/152 (28%), Positives = 73/152 (48%), Gaps = 3/152 (1%)
Query: 53 ILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLSKL 112
++ LN + G +T S TL Y + L + +V+ K++EEI V G + R + +D +K+
Sbjct: 292 MMSTLNLFI-AGTETVSTTLHYGFLLLMKHPEVEAKVHEEIDRVIGKN-RQPKFEDRAKM 349
Query: 113 VYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDDAD 171
Y EAVI E R + P+ + R + +D K ++ L G + + R + +
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGIEVFPMLGSVLRDLRFFSNPR 409
Query: 172 KFRPERWLEPDGVPSVYYAFATFGVGKRACIG 203
F P+ +L G AF F + KR C G
Sbjct: 410 DFNPQHFLGEKGQFKKRDAFVPFSIRKRNCFG 441
>S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein.
Length = 477
Score = 72.5 bits (170), Expect = 3e-12
Identities = 65/212 (30%), Positives = 95/212 (44%), Gaps = 12/212 (5%)
Query: 289 NKYQGLLD-LMLKLAKEDALTDQEIREEV--DTAIM---AGFDTSSWILVYVLVNLGSFP 342
N Q +D ++K+ KE E E +TA+ AG +T+S L Y L+ L P
Sbjct: 245 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 304
Query: 343 EVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKL 401
EV + EI V G +R +D S + YT+AV+ E R + P SL H + D+K
Sbjct: 305 EVTAKVQEEIERVIG-RNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKF 363
Query: 402 KNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP--QKIPDNAFAAFSIGKRSCT 459
+N+ + GT ISL + + F P +LD F FS GKR C
Sbjct: 364 RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICV 423
Query: 460 GRAYALTLMKINLAHLLRKYKISG--DVSKLD 489
G A A + + L +L+ + + D LD
Sbjct: 424 GEALAGMELFLFLTSILQNFNLKSLVDPKNLD 455
Score = 70.1 bits (164), Expect = 2e-11
Identities = 49/156 (31%), Positives = 72/156 (46%), Gaps = 3/156 (1%)
Query: 52 EILEELNTAVFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLS 110
E LE +FG G +TTS TL Y L+ L + +V K+ EEI+ V G + R D S
Sbjct: 272 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN-RSPCMQDRS 330
Query: 111 KLVYTEAVIKESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+ YT+AV+ E R + P + D+K NY + G I++ + +
Sbjct: 331 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN 390
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTA 205
+ F P +L+ G F F GKR C+G A
Sbjct: 391 PEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEA 426
>M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein.
Length = 515
Score = 72.5 bits (170), Expect = 3e-12
Identities = 49/157 (31%), Positives = 76/157 (48%), Gaps = 6/157 (3%)
Query: 52 EILEELNTAVFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLS 110
E + L +FG G+DT + +++ LM L T ++Q+K+ +E+ V G ER D
Sbjct: 305 EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RERRPRLSDRP 363
Query: 111 KLVYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+L Y EA I E+ R P I +D +N + + +N + +N +D
Sbjct: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423
Query: 170 ADKFRPERWLEPDGV---PSVYYAFATFGVGKRACIG 203
+FRPER+L DG + FG+GKR CIG
Sbjct: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIG 460
Score = 64.9 bits (151), Expect = 6e-10
Identities = 52/187 (27%), Positives = 85/187 (45%), Gaps = 7/187 (3%)
Query: 302 AKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDR 361
A + + ++I V+ AGFDT + + + L+ L + PE+Q + E+ V G +R
Sbjct: 297 ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RER 355
Query: 362 DLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGIN 420
D +L Y EA + ET R + P ++ H D L F + ++ + +N
Sbjct: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415
Query: 421 RHTVWGEDVNEFKPERWLDP-----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHL 475
ED +EF+PER+L K F +GKR C G A + + LA L
Sbjct: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAIL 475
Query: 476 LRKYKIS 482
L++ + S
Sbjct: 476 LQQLEFS 482
>M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein.
Length = 515
Score = 72.5 bits (170), Expect = 3e-12
Identities = 49/157 (31%), Positives = 76/157 (48%), Gaps = 6/157 (3%)
Query: 52 EILEELNTAVFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLS 110
E + L +FG G+DT + +++ LM L T ++Q+K+ +E+ V G ER D
Sbjct: 305 EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RERRPRLSDRP 363
Query: 111 KLVYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+L Y EA I E+ R P I +D +N + + +N + +N +D
Sbjct: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423
Query: 170 ADKFRPERWLEPDGV---PSVYYAFATFGVGKRACIG 203
+FRPER+L DG + FG+GKR CIG
Sbjct: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIG 460
Score = 64.9 bits (151), Expect = 6e-10
Identities = 52/187 (27%), Positives = 85/187 (45%), Gaps = 7/187 (3%)
Query: 302 AKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVNLGSFPEVQDRAYNEIMDVFGDSDR 361
A + + ++I V+ AGFDT + + + L+ L + PE+Q + E+ V G +R
Sbjct: 297 ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-RER 355
Query: 362 DLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKLKNFTLKAGTDCSISLFGIN 420
D +L Y EA + ET R + P ++ H D L F + ++ + +N
Sbjct: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415
Query: 421 RHTVWGEDVNEFKPERWLDP-----QKIPDNAFAAFSIGKRSCTGRAYALTLMKINLAHL 475
ED +EF+PER+L K F +GKR C G A + + LA L
Sbjct: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAIL 475
Query: 476 LRKYKIS 482
L++ + S
Sbjct: 476 LQQLEFS 482
>M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein.
Length = 383
Score = 72.5 bits (170), Expect = 3e-12
Identities = 65/212 (30%), Positives = 95/212 (44%), Gaps = 12/212 (5%)
Query: 289 NKYQGLLD-LMLKLAKEDALTDQEIREEV--DTAIM---AGFDTSSWILVYVLVNLGSFP 342
N Q +D ++K+ KE E E +TA+ AG +T+S L Y L+ L P
Sbjct: 151 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 210
Query: 343 EVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKL 401
EV + EI V G +R +D S + YT+AV+ E R + P SL H + D+K
Sbjct: 211 EVTAKVQEEIERVIG-RNRSPCMQDRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKF 269
Query: 402 KNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLDP--QKIPDNAFAAFSIGKRSCT 459
+N+ + GT ISL + + F P +LD F FS GKR C
Sbjct: 270 RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICV 329
Query: 460 GRAYALTLMKINLAHLLRKYKISG--DVSKLD 489
G A A + + L +L+ + + D LD
Sbjct: 330 GEALAGMELFLFLTSILQNFNLKSLVDPKNLD 361
Score = 70.1 bits (164), Expect = 2e-11
Identities = 49/156 (31%), Positives = 72/156 (46%), Gaps = 3/156 (1%)
Query: 52 EILEELNTAVFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLS 110
E LE +FG G +TTS TL Y L+ L + +V K+ EEI+ V G + R D S
Sbjct: 178 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN-RSPCMQDRS 236
Query: 111 KLVYTEAVIKESLRLYPIAPIIF-RELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+ YT+AV+ E R + P + D+K NY + G I++ + +
Sbjct: 237 HMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN 296
Query: 170 ADKFRPERWLEPDGVPSVYYAFATFGVGKRACIGTA 205
+ F P +L+ G F F GKR C+G A
Sbjct: 297 PEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEA 332
>M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 72.5 bits (170), Expect = 3e-12
Identities = 65/212 (30%), Positives = 95/212 (44%), Gaps = 12/212 (5%)
Query: 289 NKYQGLLD-LMLKLAKEDALTDQEIREEV--DTAIM---AGFDTSSWILVYVLVNLGSFP 342
N Q +D ++K+ KE E E +TA+ AG +T+S L Y L+ L P
Sbjct: 253 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 312
Query: 343 EVQDRAYNEIMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRH-IEEDVKL 401
EV + EI V G +R +D S + YT+AV+ E R + P SL H + D+K
Sbjct: 313 EVTAKVQEEIERVIG-RNRSPCMQDRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKF 371
Query: 402 KNFTLKAGTDCSISLFGINRHTVWGEDVNEFKPERWLD--PQKIPDNAFAAFSIGKRSCT 459
+N+ + GT ISL + + F P +LD F FS GKR C
Sbjct: 372 RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGDNFKKSKYFMPFSAGKRICV 431
Query: 460 GRAYALTLMKINLAHLLRKYKISG--DVSKLD 489
G A A + + L +L+ + + D LD
Sbjct: 432 GEALAGMELFLFLTSILQNFNLKSLVDPKNLD 463
Score = 68.9 bits (161), Expect = 4e-11
Identities = 51/157 (32%), Positives = 73/157 (46%), Gaps = 5/157 (3%)
Query: 52 EILEELNTAVFG-GYDTTSCTLTYVLMNLGTYQDVQQKMYEEIKNVFGDSERDVESDDLS 110
E LE +FG G +TTS TL Y L+ L + +V K+ EEI+ V G R D S
Sbjct: 280 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIG-RNRSPCMQDRS 338
Query: 111 KLVYTEAVIKESLRLYPIAPI-IFRELDQDVKINNYTLKAGRGCAINVYGINRHAMWGDD 169
+ YT+AV+ E R + P + + D+K NY + G I++ + +
Sbjct: 339 HMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN 398
Query: 170 ADKFRPERWL-EPDGVPSVYYAFATFGVGKRACIGTA 205
+ F P +L E D Y F F GKR C+G A
Sbjct: 399 PEMFDPHHFLDEGDNFKKSKY-FMPFSAGKRICVGEA 434
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.136 0.394
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 66,981,445
Number of Sequences: 224733
Number of extensions: 2709989
Number of successful extensions: 7472
Number of sequences better than 10.0: 434
Number of HSP's better than 10.0 without gapping: 355
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 5419
Number of HSP's gapped (non-prelim): 917
length of query: 510
length of database: 73,234,838
effective HSP length: 93
effective length of query: 417
effective length of database: 52,334,669
effective search space: 21823556973
effective search space used: 21823556973
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 67 (31.1 bits)
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