Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002267-TA|BGIBMGA002267-PA|IPR001128|Cytochrome P450
(415 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein. 195 3e-49
AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4 omega-hy... 194 5e-49
D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4 omega-hydr... 193 8e-49
BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family... 193 8e-49
BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family... 193 8e-49
AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfam... 193 8e-49
AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein. 193 8e-49
BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family... 193 1e-48
BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family... 192 3e-48
AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2 pro... 192 3e-48
AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens ... 192 3e-48
AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens ... 192 3e-48
AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family... 187 7e-47
AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein. 186 1e-46
AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens ... 186 2e-46
BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family... 185 2e-46
BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family... 185 2e-46
BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family... 185 2e-46
D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV prot... 184 4e-46
AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4 omega-hy... 184 4e-46
AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4 omega-hy... 184 4e-46
BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family... 184 7e-46
AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein. 184 7e-46
AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein. 183 9e-46
AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform... 183 9e-46
AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein. 183 9e-46
AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein. 183 9e-46
BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein. 178 3e-44
AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein. 178 3e-44
X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for ... 171 3e-42
J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung cyto... 171 3e-42
DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family... 171 3e-42
AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family... 171 3e-42
AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family... 171 3e-42
AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein. 171 3e-42
BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family... 171 5e-42
AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P4... 171 5e-42
AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein. 171 5e-42
AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family... 171 5e-42
AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family... 171 5e-42
AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein. 170 9e-42
AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein. 169 1e-41
S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxyl... 165 3e-40
L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein. 164 6e-40
D26481-1|BAA05491.1| 519|Homo sapiens fatty acids omega-hydroxy... 164 6e-40
AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family... 164 6e-40
AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family... 164 6e-40
S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxyl... 163 1e-39
AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein. 163 1e-39
AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein. 163 1e-39
AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family... 163 1e-39
AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family... 163 1e-39
AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfam... 162 2e-39
BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family... 162 2e-39
AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein. 162 2e-39
AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P4... 162 2e-39
AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein. 162 2e-39
AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family... 162 2e-39
AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family... 162 2e-39
AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family... 162 2e-39
AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens ... 162 2e-39
AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens ... 162 2e-39
AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22 pr... 161 3e-39
AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens ... 161 3e-39
AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K p... 159 2e-38
D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxyl... 156 1e-37
AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, famil... 156 1e-37
AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid omega-hydrox... 156 1e-37
BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein. 136 1e-31
AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family... 136 1e-31
AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, famil... 129 2e-29
D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV prot... 126 1e-28
J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3 prot... 123 1e-27
BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family... 123 1e-27
AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein. 123 1e-27
J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipin... 122 2e-27
M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver glu... 122 3e-27
D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein. 122 3e-27
AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4 pro... 122 3e-27
M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA... 121 4e-27
M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrom... 121 4e-27
DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family ... 121 4e-27
DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family... 121 4e-27
BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfam... 121 4e-27
BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family... 121 4e-27
AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family... 121 4e-27
AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein. 121 4e-27
AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein. 121 4e-27
AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450 polypep... 121 4e-27
AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4 p... 121 4e-27
X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for ... 121 5e-27
D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa pro... 118 3e-26
BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family... 118 3e-26
AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant... 118 3e-26
AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450 polypep... 118 3e-26
BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family... 112 3e-24
AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxyl... 112 3e-24
AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43... 111 4e-24
AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43... 110 8e-24
AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfami... 110 8e-24
AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43... 110 8e-24
AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfami... 110 8e-24
AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein. 110 8e-24
AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family... 107 7e-23
AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin D-1-... 107 7e-23
AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 107 7e-23
AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin ... 107 7e-23
AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin D-1-a... 107 7e-23
AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 107 7e-23
AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 107 7e-23
AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3 1a... 107 7e-23
AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3 1-... 107 7e-23
AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein. 106 1e-22
AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfami... 106 2e-22
AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein. 106 2e-22
BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein. 105 2e-22
AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein. 103 2e-21
AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens ... 100 8e-21
BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein. 95 3e-19
X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase... 95 4e-19
M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase pro... 95 4e-19
BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family... 95 4e-19
BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family... 95 4e-19
AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase pro... 94 7e-19
BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family... 91 7e-18
BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family... 91 7e-18
AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1 pro... 91 7e-18
BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family... 91 9e-18
Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for ... 90 1e-17
X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for ... 90 1e-17
M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase... 90 1e-17
M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase... 90 1e-17
M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase... 90 1e-17
DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfami... 90 1e-17
AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family... 90 1e-17
BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family... 89 2e-17
S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D 24-hy... 89 4e-17
AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylas... 89 4e-17
AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family... 89 4e-17
AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family... 89 4e-17
L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3 ... 87 8e-17
M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatas... 87 1e-16
J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein. 87 1e-16
U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450 monooxyge... 87 1e-16
BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family... 87 1e-16
AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family... 87 1e-16
AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein. 87 1e-16
AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfami... 86 2e-16
AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2 pro... 86 2e-16
X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein. 83 1e-15
M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc prot... 83 1e-15
M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein. 83 1e-15
BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family... 83 1e-15
BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family... 83 2e-15
AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein. 83 2e-15
BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family... 79 2e-14
AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family... 79 2e-14
AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family... 79 2e-14
AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase pr... 79 2e-14
AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxyla... 79 2e-14
U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase... 79 3e-14
D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase... 79 3e-14
BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family... 79 3e-14
AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein. 79 3e-14
AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens ... 79 3e-14
AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1 pro... 79 3e-14
AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein. 79 3e-14
M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase prot... 79 4e-14
BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase ... 79 4e-14
BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein. 79 4e-14
AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase ... 79 4e-14
AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase pr... 79 4e-14
AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase pr... 79 4e-14
AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase pr... 79 4e-14
AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase pr... 79 4e-14
AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase pr... 79 4e-14
AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase pr... 79 4e-14
AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase pr... 79 4e-14
D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase prot... 78 5e-14
AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens ... 78 5e-14
AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase pr... 78 5e-14
X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein. 78 7e-14
DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6 pro... 78 7e-14
AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein pr... 77 9e-14
AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein. 77 9e-14
AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase pr... 77 9e-14
U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha demet... 77 1e-13
S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein. 77 2e-13
M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6 prot... 77 2e-13
M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoqu... 77 2e-13
M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein. 77 2e-13
M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein. 77 2e-13
D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein. 77 2e-13
DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 2e-13
DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 2e-13
DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 2e-13
DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 2e-13
DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 2e-13
DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 2e-13
DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 2e-13
DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6 pro... 77 2e-13
BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family... 77 2e-13
BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family... 77 2e-13
BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family... 77 2e-13
AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family... 77 2e-13
AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6 prot... 77 2e-13
AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family... 77 2e-13
AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family... 77 2e-13
AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase pr... 77 2e-13
AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxyl... 77 2e-13
AY696295-1|AAU10524.1| 292|Homo sapiens cytochrome P450 protein. 76 3e-13
X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C pro... 75 4e-13
X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein. 75 4e-13
M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein. 75 4e-13
AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family... 75 4e-13
X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for ... 75 5e-13
M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein. 75 5e-13
BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family... 75 5e-13
BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein. 75 5e-13
AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome P-45... 75 5e-13
M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid 1... 75 6e-13
M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein. 74 8e-13
M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein. 74 8e-13
DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family... 74 8e-13
BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family... 74 8e-13
BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family... 74 8e-13
AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6 pro... 74 8e-13
AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein. 74 8e-13
X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase (P-... 74 1e-12
M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein. 74 1e-12
M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein. 74 1e-12
D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase pr... 74 1e-12
X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase ... 73 1e-12
DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6 pro... 73 1e-12
DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6 pro... 73 1e-12
DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6 pro... 73 1e-12
DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6 pro... 73 1e-12
DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6 pro... 73 1e-12
DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6 pro... 73 1e-12
DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6 pro... 73 1e-12
DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6 pro... 73 1e-12
CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein. 73 1e-12
BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family... 73 1e-12
BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family... 73 1e-12
BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family... 73 1e-12
BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family... 73 1e-12
BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein. 73 1e-12
M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein. 73 2e-12
L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxyla... 73 2e-12
L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein. 73 2e-12
AY796203-1|AAV41877.1| 490|Homo sapiens cytochrome P450, family... 73 2e-12
AL583836-2|CAH74068.1| 490|Homo sapiens cytochrome P450, family... 73 2e-12
AL133513-2|CAH73444.1| 490|Homo sapiens cytochrome P450, family... 73 2e-12
X02612-1|CAA26458.1| 512|Homo sapiens cytochrome P(1)-450 protein. 73 2e-12
K03191-1|AAA52139.1| 512|Homo sapiens CYP1A1 protein. 72 3e-12
DQ282153-1|ABB77901.1| 497|Homo sapiens cytochrome P450 2D6 pro... 72 3e-12
BC067433-1|AAH67433.1| 493|Homo sapiens cytochrome P450, family... 72 3e-12
AK223510-1|BAD97230.1| 490|Homo sapiens cytochrome P450, family... 72 3e-12
X13930-1|CAA32118.1| 494|Homo sapiens protein ( Human CYP2A4 mR... 72 4e-12
X13929-1|CAA32117.1| 448|Homo sapiens P-450 IIA3 protein (1 is ... 72 4e-12
X04300-1|CAA27843.1| 512|Homo sapiens P-450 c protein. 72 4e-12
M61856-1|AAB59356.1| 490|Homo sapiens cytochrome protein. 72 4e-12
M33318-1|AAA52067.1| 494|Homo sapiens CYP2A protein. 72 4e-12
EF094025-1|ABK41999.1| 512|Homo sapiens cytochrome P450, family... 72 4e-12
BX538127-1|CAD98029.1| 310|Homo sapiens hypothetical protein pr... 72 4e-12
BC096260-1|AAH96260.1| 431|Homo sapiens CYP2C18 protein protein. 72 4e-12
BC096258-1|AAH96258.1| 490|Homo sapiens cytochrome P450, family... 72 4e-12
BC096257-1|AAH96257.1| 490|Homo sapiens cytochrome P450, family... 72 4e-12
BC096256-1|AAH96256.1| 494|Homo sapiens cytochrome P450, family... 72 4e-12
BC096255-1|AAH96255.1| 494|Homo sapiens cytochrome P450, family... 72 4e-12
BC096254-1|AAH96254.1| 494|Homo sapiens cytochrome P450, family... 72 4e-12
BC096253-1|AAH96253.3| 494|Homo sapiens cytochrome P450, family... 72 4e-12
BC069666-1|AAH69666.1| 490|Homo sapiens cytochrome P450, family... 72 4e-12
BC023019-1|AAH23019.1| 512|Homo sapiens cytochrome P450, family... 72 4e-12
AL583836-1|CAH74067.1| 490|Homo sapiens cytochrome P450, family... 72 4e-12
AK223113-1|BAD96833.1| 512|Homo sapiens cytochrome P450, family... 72 4e-12
AF253322-1|AAK25727.1| 512|Homo sapiens cytochrome P450 protein. 72 4e-12
AF182275-1|AAF13600.1| 494|Homo sapiens cytochrome P450-2A6 pro... 72 4e-12
AY513608-1|AAR90939.1| 494|Homo sapiens cytochrome P450 2A13 va... 71 6e-12
AY513606-1|AAR90937.1| 494|Homo sapiens cytochrome P450 2A13 va... 71 6e-12
AY513605-1|AAR90936.1| 494|Homo sapiens cytochrome P450 2A13 va... 71 6e-12
AY513604-1|AAR90935.1| 494|Homo sapiens cytochrome P450 2A13 va... 71 6e-12
AY064484-1|AAL57719.1| 295|Homo sapiens truncated cytochrome P4... 71 6e-12
AF209774-1|AAG35775.1| 494|Homo sapiens cytochrome P450 2A13 pr... 71 6e-12
L16876-1|AAA02630.1| 490|Homo sapiens cytochrome P-4502C18 prot... 71 8e-12
J02843-1|AAA52155.1| 493|Homo sapiens protein ( Human cytochrom... 71 8e-12
J02625-1|AAA35743.1| 493|Homo sapiens protein ( Human cytochrom... 71 8e-12
DQ515958-1|ABF47105.1| 493|Homo sapiens cytochrome P450, family... 71 8e-12
DQ149222-1|AAZ77710.1| 493|Homo sapiens cytochrome P450 2E1 pro... 71 8e-12
AY513609-1|AAR90940.1| 494|Homo sapiens cytochrome P450 2A13 va... 71 8e-12
AM086564-1|CAJ31103.1| 494|Homo sapiens steroid 21-hydroxylase,... 71 8e-12
AL161645-2|CAH70047.1| 493|Homo sapiens cytochrome P450, family... 71 8e-12
AF084225-1|AAD13753.1| 462|Homo sapiens cytochrome P450 2E1 pro... 71 8e-12
M24667-1|AAA52148.1| 256|Homo sapiens steroid 11-beta-hydroxyla... 71 1e-11
AM183949-1|CAJ75803.1| 494|Homo sapiens steroid 21-hydroxylase,... 71 1e-11
X13897-1|CAA32097.1| 489|Homo sapiens protein ( Human mRNA for ... 70 1e-11
M33317-1|AAA52138.1| 494|Homo sapiens CYP2A protein. 70 1e-11
M26856-1|AAA52064.1| 495|Homo sapiens protein ( Human 21-hydrox... 70 1e-11
M13936-1|AAA59695.1| 494|Homo sapiens CYP21P protein. 70 1e-11
K03192-1|AAA52147.1| 331|Homo sapiens CYP1A1 protein. 70 1e-11
BX679671-8|CAM26071.1| 464|Homo sapiens cytochrome P450, family... 70 1e-11
BX679671-7|CAM26070.1| 494|Homo sapiens cytochrome P450, family... 70 1e-11
BC125182-1|AAI25183.1| 494|Homo sapiens cytochrome P450, family... 70 1e-11
BC125181-1|AAI25182.1| 495|Homo sapiens cytochrome P450, family... 70 1e-11
BC117165-1|AAI17166.1| 494|Homo sapiens cytochrome P450, family... 70 1e-11
BC067435-1|AAH67435.1| 493|Homo sapiens cytochrome P450, family... 70 1e-11
AM183951-1|CAJ75805.1| 494|Homo sapiens steroid 21-hydroxylase,... 70 1e-11
AM086565-1|CAJ31104.1| 494|Homo sapiens steroid 21-hydroxylase,... 70 1e-11
AL929593-2|CAI41778.1| 465|Homo sapiens cytochrome P450, family... 70 1e-11
AL929593-1|CAI41779.1| 495|Homo sapiens cytochrome P450, family... 70 1e-11
AL662849-19|CAI17480.1| 465|Homo sapiens cytochrome P450, famil... 70 1e-11
AL662849-18|CAI17479.1| 495|Homo sapiens cytochrome P450, famil... 70 1e-11
AL645922-24|CAI41754.1| 495|Homo sapiens cytochrome P450, famil... 70 1e-11
AL645922-23|CAI41755.1| 465|Homo sapiens cytochrome P450, famil... 70 1e-11
AL049547-7|CAB89301.1| 495|Homo sapiens dJ34F7.3 (cytochrome P4... 70 1e-11
AF182276-1|AAF13601.1| 493|Homo sapiens cytochrome P450-2E1 pro... 70 1e-11
AF077974-1|AAD45405.1| 403|Homo sapiens cytochrome P450 21-hydr... 70 1e-11
AF019413-2|AAB67982.1| 495|Homo sapiens cytochrome P450 21-hydr... 70 1e-11
M63871-1|AAA59984.1| 508|Homo sapiens CYP17 protein. 70 2e-11
M31153-1|AAA52140.1| 508|Homo sapiens CYP17 protein. 70 2e-11
M28548-1|AAA52065.1| 495|Homo sapiens protein ( Human mutant 21... 70 2e-11
M21550-1|AAA52063.1| 495|Homo sapiens CYP21 protein. 70 2e-11
M19489-1|AAA36405.1| 508|Homo sapiens CYP17 protein. 70 2e-11
M14564-1|AAA52151.1| 508|Homo sapiens CYP17 protein. 70 2e-11
DQ530598-1|ABF50972.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
BT020000-1|AAV38803.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
BC063388-1|AAH63388.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
BC062997-1|AAH62997.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
AL358790-3|CAI52498.1| 508|Homo sapiens cytochrome P450, family... 70 2e-11
BC100982-1|AAI00983.1| 280|Homo sapiens CYP3A43 protein protein. 69 2e-11
BC067429-1|AAH67429.1| 516|Homo sapiens cytochrome P450, family... 69 2e-11
AM183947-1|CAJ75801.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 2e-11
AM183946-1|CAJ75800.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 2e-11
AM183945-1|CAJ75799.1| 494|Homo sapiens steroid 21-hydroxylase,... 69 2e-11
AK223108-1|BAD96828.1| 512|Homo sapiens cytochrome P450, family... 69 3e-11
AM183950-1|CAJ75804.1| 494|Homo sapiens steroid 21-hydroxylase,... 68 5e-11
AM183948-1|CAJ75802.1| 494|Homo sapiens steroid 21-hydroxylase ... 68 5e-11
M17397-1|AAA35739.1| 490|Homo sapiens protein ( Human cytochrom... 67 9e-11
M12792-1|AAB59440.1| 494|Homo sapiens steroid 21-hydroxylase pr... 67 9e-11
BC025761-1|AAH25761.2| 490|Homo sapiens cytochrome P450, family... 67 1e-10
AF237982-1|AAF63329.1| 469|Homo sapiens oxysterol 7alpha-hydrox... 66 2e-10
Z00036-1|CAA77335.1| 515|Homo sapiens protein ( Human mRNA for ... 66 2e-10
U03688-1|AAA19567.1| 543|Homo sapiens cytochrome P450 protein. 66 2e-10
M55053-1|AAA52146.1| 515|Homo sapiens cytochrome P3-450 protein. 66 2e-10
M31667-1|AAA52163.1| 515|Homo sapiens CYP1A2 protein. 66 2e-10
L00389-1|AAA35738.1| 516|Homo sapiens protein ( Human cytochrom... 66 2e-10
DQ022432-1|AAY26399.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BT020001-1|AAV38804.1| 543|Homo sapiens cytochrome P450, family... 66 2e-10
BC067428-1|AAH67428.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC067427-1|AAH67427.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC067426-1|AAH67426.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC067425-1|AAH67425.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC067424-1|AAH67424.1| 516|Homo sapiens cytochrome P450, family... 66 2e-10
BC012049-1|AAH12049.1| 543|Homo sapiens cytochrome P450, family... 66 2e-10
AY310359-1|AAQ76692.1| 484|Homo sapiens cytochrome P450 1A1 var... 66 2e-10
AK054616-1|BAB70774.1| 465|Homo sapiens protein ( Homo sapiens ... 66 2e-10
AF253322-2|AAK25728.1| 516|Homo sapiens cytochrome P450 protein. 66 2e-10
AC009229-2|AAY15039.1| 543|Homo sapiens unknown protein. 66 2e-10
Y00498-1|CAA68550.1| 490|Homo sapiens IIC2 protein. 66 3e-10
U22028-1|AAB40519.1| 494|Homo sapiens cytochrome P450 protein. 66 3e-10
BC020596-1|AAH20596.1| 490|Homo sapiens cytochrome P450, family... 66 3e-10
BC010358-1|AAH10358.1| 469|Homo sapiens cytochrome P450, family... 66 3e-10
AY514490-1|AAR89907.1| 490|Homo sapiens cytochrome P450, family... 66 3e-10
AL591242-1|CAH73899.1| 469|Homo sapiens cytochrome P450, family... 66 3e-10
AL359672-5|CAH71307.1| 490|Homo sapiens cytochrome P450, family... 66 3e-10
AL035670-1|CAI20276.1| 469|Homo sapiens cytochrome P450, family... 66 3e-10
AF182274-1|AAF13599.1| 516|Homo sapiens cytochrome P450-1A2 pro... 66 3e-10
M21942-1|AAA52161.1| 462|Homo sapiens CYP2C protein. 65 4e-10
U56438-1|AAC50809.1| 543|Homo sapiens dioxin-inducible cytochro... 65 5e-10
M21941-1|AAA52160.1| 480|Homo sapiens CYP2C protein. 65 5e-10
BT019979-1|AAV38782.1| 543|Homo sapiens cytochrome P450, family... 65 5e-10
AY393998-1|AAQ87875.1| 543|Homo sapiens cytochrome P450, family... 65 5e-10
AF450132-1|AAM50512.1| 543|Homo sapiens cytochrome P450 CYP1B1 ... 65 5e-10
AM236047-1|CAJ84704.1| 251|Homo sapiens cytochrome P450 1A1 pro... 64 7e-10
U22029-1|AAB40520.1| 494|Homo sapiens cytochrome P450 protein. 64 9e-10
X51535-1|CAA35915.1| 210|Homo sapiens cytochrome P-450 HPH (120... 63 2e-09
M12078-1|AAA52154.1| 192|Homo sapiens POR protein. 63 2e-09
AF221943-1|AAF86378.1| 175|Homo sapiens leukotriene B4 omega hy... 63 2e-09
U22027-1|AAB40518.1| 494|Homo sapiens cytochrome P450 protein. 62 3e-09
M12079-1|AAA52152.1| 191|Homo sapiens POR protein. 62 4e-09
AF372573-1|AAL69652.1| 495|Homo sapiens cytochrome P450 2F1 pro... 62 4e-09
M17252-1|AAA59985.1| 230|Homo sapiens CYP21 protein. 62 5e-09
J02906-1|AAA52156.1| 491|Homo sapiens CYP2F1 protein. 61 6e-09
DQ680079-1|ABG25922.1| 347|Homo sapiens truncated cytochrome P4... 60 1e-08
BC096259-1|AAH96259.1| 443|Homo sapiens CYP2C18 protein protein. 59 3e-08
DQ016495-1|AAY34975.1| 195|Homo sapiens cytochrome P450 1B1 pro... 58 4e-08
AB209700-1|BAD92937.1| 336|Homo sapiens cytochrome P450, family... 58 4e-08
AY359068-1|AAQ89427.1| 462|Homo sapiens P450-like protein protein. 58 8e-08
BC093022-1|AAH93022.1| 416|Homo sapiens CYP20A1 protein protein. 57 1e-07
BC033752-1|AAH33752.1| 462|Homo sapiens cytochrome P450, family... 57 1e-07
BC020616-1|AAH20616.1| 462|Homo sapiens cytochrome P450, family... 57 1e-07
L16883-1|AAD13467.1| 169|Homo sapiens cytochrome P-450 2C protein. 56 3e-07
AF183412-1|AAG09681.1| 435|Homo sapiens cytochrome P450 monooxy... 55 5e-07
AY220845-1|AAO49806.1| 516|Homo sapiens cytochrome P450 protein. 54 7e-07
AK000366-1|BAA91114.1| 408|Homo sapiens protein ( Homo sapiens ... 51 7e-06
M80646-1|AAA60617.1| 460|Homo sapiens thromboxane synthase prot... 50 1e-05
AC011737-1|AAX88915.1| 382|Homo sapiens unknown protein. 50 1e-05
BC109084-1|AAI09085.1| 448|Homo sapiens CYP24A1 protein protein. 50 2e-05
BC109083-1|AAI09084.1| 448|Homo sapiens CYP24A1 protein protein. 50 2e-05
AL138805-2|CAM27343.1| 448|Homo sapiens cytochrome P450, family... 50 2e-05
BC109205-1|AAI09206.1| 512|Homo sapiens cytochrome P450, family... 50 2e-05
BC069443-1|AAH69443.1| 512|Homo sapiens cytochrome P450, family... 50 2e-05
BC022851-1|AAH22851.1| 215|Homo sapiens CYP4A11 protein protein. 50 2e-05
AF252297-1|AAF76003.1| 512|Homo sapiens cytochrome P450 retinoi... 50 2e-05
AC007002-1|AAY14690.1| 512|Homo sapiens unknown protein. 50 2e-05
BC056258-1|AAH56258.1| 359|Homo sapiens CYP19A1 protein protein. 47 1e-04
BC020767-1|AAH20767.1| 360|Homo sapiens Unknown (protein for IM... 47 1e-04
M17398-1|AAA35740.1| 393|Homo sapiens protein ( Human cytochrom... 46 2e-04
AF144566-1|AAD30164.1| 339|Homo sapiens cytochrome P450 epoxyge... 46 3e-04
M29873-1|AAA52143.1| 377|Homo sapiens CYP2B protein. 44 8e-04
BC041174-1|AAH41174.1| 377|Homo sapiens CYP2B7P1 protein protein. 44 8e-04
AJ563379-2|CAD91649.1| 84|Homo sapiens cytochrome P450 protein. 44 0.001
AK127151-1|BAC86855.1| 146|Homo sapiens protein ( Homo sapiens ... 43 0.002
S77409-1|AAB34643.1| 228|Homo sapiens steroid 18-hydroxylase pr... 40 0.012
AB209749-1|BAD92986.1| 210|Homo sapiens cytochrome P450, family... 40 0.012
BC096286-1|AAH96286.1| 437|Homo sapiens cytochrome P450, family... 39 0.028
AY356349-1|AAQ55485.1| 522|Homo sapiens cytochrome P450 protein. 39 0.028
AL358613-1|CAH72802.2| 522|Homo sapiens cytochrome P450, family... 39 0.028
BC128535-1|AAI28536.1| 143|Homo sapiens LOC283480 protein protein. 39 0.037
AK094090-1|BAC04283.1| 153|Homo sapiens protein ( Homo sapiens ... 38 0.086
AJ877238-1|CAI47002.1| 97|Homo sapiens putative cytochrome P45... 36 0.20
L36085-1|AAC01761.1| 441|Homo sapiens thromboxane A2 synthase p... 36 0.35
BC069194-1|AAH69194.1| 1118|Homo sapiens PHLDB2 protein protein. 33 1.4
AJ496194-1|CAD42711.1| 1253|Homo sapiens LL5 beta protein protein. 33 1.4
AF506820-1|AAM33634.1| 1210|Homo sapiens hypothetical protein pr... 33 1.4
AB209903-1|BAD93140.1| 1259|Homo sapiens LL5 beta protein varian... 33 1.4
M83216-2|AAA58420.1| 538|Homo sapiens caldesmon protein. 32 3.2
M64110-1|AAA35636.1| 538|Homo sapiens caldesmon protein. 32 3.2
D90453-1|BAA14419.1| 532|Homo sapiens l-caldesmon II protein. 32 3.2
BC040354-1|AAH40354.1| 538|Homo sapiens caldesmon 1 protein. 32 3.2
BC014035-1|AAH14035.1| 314|Homo sapiens CALD1 protein protein. 32 3.2
AF280111-1|AAG33012.1| 250|Homo sapiens cytochrome P450 subfami... 32 3.2
AF247820-1|AAF69498.3| 481|Homo sapiens NAG22 protein protein. 32 3.2
BC112167-1|AAI12168.1| 1429|Homo sapiens mutL homolog 3 (E. coli... 32 4.3
AY963685-1|AAX59030.1| 1429|Homo sapiens mutL 3 homolog (E.coli)... 32 4.3
AF535142-1|AAN03486.1| 8749|Homo sapiens enaptin protein. 32 4.3
AF195658-1|AAF23905.1| 1429|Homo sapiens DNA mismatch repair pro... 32 4.3
AF195657-1|AAF23904.1| 1429|Homo sapiens DNA mismatch repair pro... 32 4.3
AB039667-1|BAA92353.1| 1453|Homo sapiens DNA mismatch repair pro... 32 4.3
BC038515-1|AAH38515.1| 796|Homo sapiens CCDC110 protein protein. 31 7.5
AL391602-1|CAI12788.3| 1661|Homo sapiens novel protein protein. 31 9.9
AL132768-4|CAI21460.3| 1661|Homo sapiens novel protein protein. 31 9.9
AL079335-1|CAI42289.3| 1661|Homo sapiens novel protein protein. 31 9.9
AF225417-1|AAG09719.1| 779|Homo sapiens 88.8 kDa protein protein. 31 9.9
>U02388-1|AAC50052.2| 520|Homo sapiens cytochrome P450 4F2 protein.
Length = 520
Score = 195 bits (475), Expect = 3e-49
Identities = 118/375 (31%), Positives = 193/375 (51%), Gaps = 12/375 (3%)
Query: 24 FFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQ 82
FFY F WLGDGL+ S+G+ W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLL 181
Query: 83 MKSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILL 140
G + M L +L F + + +Y+ A+ E+ A++++R ILL
Sbjct: 182 ASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILL 241
Query: 141 HNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDL 200
H F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+
Sbjct: 242 HIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301
Query: 201 LL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSV 258
LL K D + +D++IR E DT +F G DT++ +++ V+ L +PE Q++ QE++ +
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASVLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 259 CGD---SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSN 314
D + + D L H L + +KE+LR++P PV+ R +I L IP
Sbjct: 362 LKDREPKEIEWDDLAH--LPFLTMCMKESLRVHPPVPVISRHVTQDIVLPDGRVIPKGII 419
Query: 315 CMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMK 374
C++ ++G + +P PD + P R+ P AF FS G RNCIG+T+A+ MK
Sbjct: 420 CLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMK 479
Query: 375 TTLVHLLRRYKVTAD 389
L L R++V D
Sbjct: 480 VVLALTLLRFRVLPD 494
>AB015306-1|BAA75823.1| 520|Homo sapiens Leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 194 bits (473), Expect = 5e-49
Identities = 119/375 (31%), Positives = 192/375 (51%), Gaps = 12/375 (3%)
Query: 24 FFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQ 82
FFY F WLGDGL+ S+G+ W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLL 181
Query: 83 MKSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILL 140
G + M L +L F + + +Y+ A+ E+ A++++R ILL
Sbjct: 182 ASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILL 241
Query: 141 HNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDL 200
H F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+
Sbjct: 242 HIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301
Query: 201 LL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSV 258
LL K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 259 CGD---SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSN 314
D + + D L H L + +KE+LRL+P PV+ R +I L IP
Sbjct: 362 LKDREPKEIEWDDLAH--LPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGII 419
Query: 315 CMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMK 374
C++ ++G + +P PD + P R+ P AF FS G RNCIG+T+A+ MK
Sbjct: 420 CLISVFGTHHNPAMWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMK 479
Query: 375 TTLVHLLRRYKVTAD 389
L L R++V D
Sbjct: 480 VVLALTLLRFRVLPD 494
>D26480-1|BAA05490.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 193 bits (471), Expect = 8e-49
Identities = 119/375 (31%), Positives = 192/375 (51%), Gaps = 12/375 (3%)
Query: 24 FFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQ 82
FFY F WLGDGL+ S+G+ W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLL 181
Query: 83 MKSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILL 140
G + M L +L F + + +Y+ A+ E+ A++++R ILL
Sbjct: 182 ASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILL 241
Query: 141 HNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDL 200
H F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+
Sbjct: 242 HIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301
Query: 201 LL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSV 258
LL K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 259 CGD---SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSN 314
D + + D L H L + +KE+LRL+P PV+ R +I L IP
Sbjct: 362 LKDREPKEIEWDDLAH--LPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGII 419
Query: 315 CMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMK 374
C++ ++G + +P PD + P R+ P AF FS G RNCIG+T+A+ MK
Sbjct: 420 CLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMK 479
Query: 375 TTLVHLLRRYKVTAD 389
L L R++V D
Sbjct: 480 VVLALTLLRFRVLPD 494
>BC067439-1|AAH67439.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 193 bits (471), Expect = 8e-49
Identities = 119/375 (31%), Positives = 192/375 (51%), Gaps = 12/375 (3%)
Query: 24 FFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQ 82
FFY F WLGDGL+ S+G+ W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLL 181
Query: 83 MKSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILL 140
G + M L +L F + + +Y+ A+ E+ A++++R ILL
Sbjct: 182 ASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILL 241
Query: 141 HNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDL 200
H F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+
Sbjct: 242 HIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301
Query: 201 LL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSV 258
LL K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 259 CGD---SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSN 314
D + + D L H L + +KE+LRL+P PV+ R +I L IP
Sbjct: 362 LKDREPKEIEWDDLAH--LPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGII 419
Query: 315 CMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMK 374
C++ ++G + +P PD + P R+ P AF FS G RNCIG+T+A+ MK
Sbjct: 420 CLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMK 479
Query: 375 TTLVHLLRRYKVTAD 389
L L R++V D
Sbjct: 480 VVLALTLLRFRVLPD 494
>BC067437-1|AAH67437.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 193 bits (471), Expect = 8e-49
Identities = 119/375 (31%), Positives = 192/375 (51%), Gaps = 12/375 (3%)
Query: 24 FFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQ 82
FFY F WLGDGL+ S+G+ W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLL 181
Query: 83 MKSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILL 140
G + M L +L F + + +Y+ A+ E+ A++++R ILL
Sbjct: 182 ASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILL 241
Query: 141 HNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDL 200
H F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+
Sbjct: 242 HIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301
Query: 201 LL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSV 258
LL K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 259 CGD---SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSN 314
D + + D L H L + +KE+LRL+P PV+ R +I L IP
Sbjct: 362 LKDREPKEIEWDDLAH--LPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGII 419
Query: 315 CMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMK 374
C++ ++G + +P PD + P R+ P AF FS G RNCIG+T+A+ MK
Sbjct: 420 CLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMK 479
Query: 375 TTLVHLLRRYKVTAD 389
L L R++V D
Sbjct: 480 VVLALTLLRFRVLPD 494
>AF467894-1|AAL67578.1| 520|Homo sapiens cytochrome P450, subfamily
IVF, polypeptide 2 protein.
Length = 520
Score = 193 bits (471), Expect = 8e-49
Identities = 119/375 (31%), Positives = 192/375 (51%), Gaps = 12/375 (3%)
Query: 24 FFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQ 82
FFY F WLGDGL+ S+G+ W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLL 181
Query: 83 MKSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILL 140
G + M L +L F + + +Y+ A+ E+ A++++R ILL
Sbjct: 182 ASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILL 241
Query: 141 HNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDL 200
H F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+
Sbjct: 242 HIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301
Query: 201 LL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSV 258
LL K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 259 CGD---SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSN 314
D + + D L H L + +KE+LRL+P PV+ R +I L IP
Sbjct: 362 LKDREPKEIEWDDLAH--LPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGII 419
Query: 315 CMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMK 374
C++ ++G + +P PD + P R+ P AF FS G RNCIG+T+A+ MK
Sbjct: 420 CLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMK 479
Query: 375 TTLVHLLRRYKVTAD 389
L L R++V D
Sbjct: 480 VVLALTLLRFRVLPD 494
>AC005336-1|AAC27730.1| 520|Homo sapiens CYP4F2 protein.
Length = 520
Score = 193 bits (471), Expect = 8e-49
Identities = 119/375 (31%), Positives = 192/375 (51%), Gaps = 12/375 (3%)
Query: 24 FFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQ 82
FFY F WLGDGL+ S+G+ W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLL 181
Query: 83 MKSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILL 140
G + M L +L F + + +Y+ A+ E+ A++++R ILL
Sbjct: 182 ASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILL 241
Query: 141 HNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDL 200
H F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+
Sbjct: 242 HIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301
Query: 201 LL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSV 258
LL K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 259 CGD---SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSN 314
D + + D L H L + +KE+LRL+P PV+ R +I L IP
Sbjct: 362 LKDREPKEIEWDDLAH--LPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGII 419
Query: 315 CMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMK 374
C++ ++G + +P PD + P R+ P AF FS G RNCIG+T+A+ MK
Sbjct: 420 CLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMK 479
Query: 375 TTLVHLLRRYKVTAD 389
L L R++V D
Sbjct: 480 VVLALTLLRFRVLPD 494
>BC067440-1|AAH67440.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 2 protein.
Length = 520
Score = 193 bits (470), Expect = 1e-48
Identities = 118/375 (31%), Positives = 192/375 (51%), Gaps = 12/375 (3%)
Query: 24 FFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQ 82
FFY F WLGDGL+ S+G+ W RHR++L PAF +L Y +FN +S N++ A ++
Sbjct: 123 FFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFN-DSVNIMHAKWQLL 181
Query: 83 MKSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILL 140
G + M L +L F + + +Y+ A+ E+ A++++R ILL
Sbjct: 182 ASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILL 241
Query: 141 HNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDL 200
H F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+
Sbjct: 242 HIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301
Query: 201 LL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSV 258
LL K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 259 CGD---SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSN 314
D + + D L H L + +KE+LRL+P PV+ R +I L IP
Sbjct: 362 LKDREPKEIEWDDLAH--LPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGII 419
Query: 315 CMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMK 374
C++ ++G + +P PD + P R+ P AF FS G RNCIG+T+A+ MK
Sbjct: 420 CLISVFGTHHNPAMWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMK 479
Query: 375 TTLVHLLRRYKVTAD 389
L L R++V D
Sbjct: 480 VVLALTLLRFRVLPD 494
>BC060857-1|AAH60857.1| 525|Homo sapiens cytochrome P450, family 4,
subfamily V, polypeptide 2 protein.
Length = 525
Score = 192 bits (467), Expect = 3e-48
Identities = 116/403 (28%), Positives = 199/403 (49%), Gaps = 8/403 (1%)
Query: 20 LHKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAI 79
+ K Y+F WLG GL+TS+G W+ RK+L P F +L + + N ++ L+ +
Sbjct: 118 IDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKL 177
Query: 80 EIQMKSGPVLISAAFKEMALKALLSTAFGIEV-EECDFNQKYMHAVDEVMAVLTRRFQNI 138
E + AL + TA G + + + + +Y+ AV + ++ RR +
Sbjct: 178 EKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMP 237
Query: 139 LLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG---CASEKKTQ 195
L Y + + + ++ + T +N VI + + ++ +G S+ K +
Sbjct: 238 WLWLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRR 297
Query: 196 SMSDLLLKGLDDEA--FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQ 253
+ DLLL DDE + ++IR EVDT +F G DT++ + + LLGS PE+Q KV
Sbjct: 298 AFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDH 357
Query: 254 EIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANS 313
E+ V G SD +L Y E V+KETLRL+P P+ R + ++ Y + +
Sbjct: 358 ELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGT 417
Query: 314 NCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISM 373
++ Y L+R P + P+ F+PER+ P A+ FS G RNCIG+ +A++
Sbjct: 418 EAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEE 477
Query: 374 KTTLVHLLRRYKVTADISKIEFKLDALMV--PSDNCYAKFESR 414
KT L +LR + + ++ + E L+ ++ PS+ + K + R
Sbjct: 478 KTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
>AY422002-1|AAR31180.1| 525|Homo sapiens cytochrome P450 4V2
protein.
Length = 525
Score = 192 bits (467), Expect = 3e-48
Identities = 116/403 (28%), Positives = 199/403 (49%), Gaps = 8/403 (1%)
Query: 20 LHKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAI 79
+ K Y+F WLG GL+TS+G W+ RK+L P F +L + + N ++ L+ +
Sbjct: 118 IDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKL 177
Query: 80 EIQMKSGPVLISAAFKEMALKALLSTAFGIEV-EECDFNQKYMHAVDEVMAVLTRRFQNI 138
E + AL + TA G + + + + +Y+ AV + ++ RR +
Sbjct: 178 EKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMP 237
Query: 139 LLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG---CASEKKTQ 195
L Y + + + ++ + T +N VI + + ++ +G S+ K +
Sbjct: 238 WLWLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRR 297
Query: 196 SMSDLLLKGLDDEA--FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQ 253
+ DLLL DDE + ++IR EVDT +F G DT++ + + LLGS PE+Q KV
Sbjct: 298 AFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDH 357
Query: 254 EIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANS 313
E+ V G SD +L Y E V+KETLRL+P P+ R + ++ Y + +
Sbjct: 358 ELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGT 417
Query: 314 NCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISM 373
++ Y L+R P + P+ F+PER+ P A+ FS G RNCIG+ +A++
Sbjct: 418 EAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEE 477
Query: 374 KTTLVHLLRRYKVTADISKIEFKLDALMV--PSDNCYAKFESR 414
KT L +LR + + ++ + E L+ ++ PS+ + K + R
Sbjct: 478 KTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
>AK126473-1|BAC86562.1| 503|Homo sapiens protein ( Homo sapiens
cDNA FLJ44509 fis, clone UTERU3001585, weakly similar
to Cytochrome P450 4c3 (EC 1.14.-.-). ).
Length = 503
Score = 192 bits (467), Expect = 3e-48
Identities = 116/403 (28%), Positives = 199/403 (49%), Gaps = 8/403 (1%)
Query: 20 LHKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAI 79
+ K Y+F WLG GL+TS+G W+ RK+L P F +L + + N ++ L+ +
Sbjct: 96 IDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKL 155
Query: 80 EIQMKSGPVLISAAFKEMALKALLSTAFGIEV-EECDFNQKYMHAVDEVMAVLTRRFQNI 138
E + AL + TA G + + + + +Y+ AV + ++ RR +
Sbjct: 156 EKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMP 215
Query: 139 LLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG---CASEKKTQ 195
L Y + + + ++ + T +N VI + + ++ +G S+ K +
Sbjct: 216 WLWLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRR 275
Query: 196 SMSDLLLKGLDDEA--FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQ 253
+ DLLL DDE + ++IR EVDT +F G DT++ + + LLGS PE+Q KV
Sbjct: 276 AFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDH 335
Query: 254 EIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANS 313
E+ V G SD +L Y E V+KETLRL+P P+ R + ++ Y + +
Sbjct: 336 ELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGT 395
Query: 314 NCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISM 373
++ Y L+R P + P+ F+PER+ P A+ FS G RNCIG+ +A++
Sbjct: 396 EAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEE 455
Query: 374 KTTLVHLLRRYKVTADISKIEFKLDALMV--PSDNCYAKFESR 414
KT L +LR + + ++ + E L+ ++ PS+ + K + R
Sbjct: 456 KTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 498
>AK122600-1|BAC85487.1| 525|Homo sapiens protein ( Homo sapiens
cDNA FLJ16007 fis, clone KIDNE2006580, weakly similar
to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
Length = 525
Score = 192 bits (467), Expect = 3e-48
Identities = 116/403 (28%), Positives = 199/403 (49%), Gaps = 8/403 (1%)
Query: 20 LHKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAI 79
+ K Y+F WLG GL+TS+G W+ RK+L P F +L + + N ++ L+ +
Sbjct: 118 IDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKL 177
Query: 80 EIQMKSGPVLISAAFKEMALKALLSTAFGIEV-EECDFNQKYMHAVDEVMAVLTRRFQNI 138
E + AL + TA G + + + + +Y+ AV + ++ RR +
Sbjct: 178 EKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMP 237
Query: 139 LLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG---CASEKKTQ 195
L Y + + + ++ + T +N VI + + ++ +G S+ K +
Sbjct: 238 WLWLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRR 297
Query: 196 SMSDLLLKGLDDEA--FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQ 253
+ DLLL DDE + ++IR EVDT +F G DT++ + + LLGS PE+Q KV
Sbjct: 298 AFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDH 357
Query: 254 EIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANS 313
E+ V G SD +L Y E V+KETLRL+P P+ R + ++ Y + +
Sbjct: 358 ELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGT 417
Query: 314 NCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISM 373
++ Y L+R P + P+ F+PER+ P A+ FS G RNCIG+ +A++
Sbjct: 418 EAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEE 477
Query: 374 KTTLVHLLRRYKVTADISKIEFKLDALMV--PSDNCYAKFESR 414
KT L +LR + + ++ + E L+ ++ PS+ + K + R
Sbjct: 478 KTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
>AY792513-1|AAV40834.1| 520|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 3 protein.
Length = 520
Score = 187 bits (455), Expect = 7e-47
Identities = 116/372 (31%), Positives = 190/372 (51%), Gaps = 8/372 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQM 83
FY F WLGDGL+ S+GE W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 124 FYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLLA 182
Query: 84 KSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
G + M L +L F + + +Y+ A+ E+ A++T+R Q ILL+
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLY 242
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+L
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 202 L--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 303 LLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362
Query: 260 GDSD-ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCML 317
D + +++ +L + +KE+LRL+P P V R +I L IP C++
Sbjct: 363 KDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLI 422
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
++G + +P PD + P R+ P AF FS G RNCIG+ +A+ MK L
Sbjct: 423 SVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 378 VHLLRRYKVTAD 389
L R++V D
Sbjct: 483 GLTLLRFRVLPD 494
>AF054821-1|AAC08589.1| 520|Homo sapiens cytochrome P-450 protein.
Length = 520
Score = 186 bits (454), Expect = 1e-46
Identities = 117/372 (31%), Positives = 190/372 (51%), Gaps = 8/372 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMK 84
FY F WLGDGL+ S+GE W RHR++L PAF +L Y +FN ES N++ A +
Sbjct: 124 FYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLLA 182
Query: 85 SGPVLISAAFKE---MALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
S F+ M L +L F + + +Y+ A+ E+ A++T+R Q ILL+
Sbjct: 183 SKGYARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLY 242
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+L
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 202 L--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 303 LLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362
Query: 260 GDSD-ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCML 317
D + +++ +L + +KE+LRL+P P V R +I L IP C++
Sbjct: 363 KDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLI 422
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
++G + +P PD + P R+ P AF FS G RNCIG+ +A+ MK L
Sbjct: 423 SVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 378 VHLLRRYKVTAD 389
L R++V D
Sbjct: 483 GLTLLRFRVLPD 494
>AK096820-1|BAC04868.1| 531|Homo sapiens protein ( Homo sapiens
cDNA FLJ39501 fis, clone PROST2016980, moderately
similar to CYTOCHROME P450 4F2 (EC 1.14.13.30). ).
Length = 531
Score = 186 bits (452), Expect = 2e-46
Identities = 119/396 (30%), Positives = 202/396 (51%), Gaps = 10/396 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMK 84
FY F WLGDGL+ S G+ W RHR+LL PAF +L Y +FN +S +++ A +
Sbjct: 132 FYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFN-QSADIMHAKWRHLA 190
Query: 85 SGPVLISAAFKE---MALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
G + F+ M L +L F + Y+ A+ E+ A+ RR + +
Sbjct: 191 EGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y SA ++ + + + + +VI +RRAL+ +Q + A + KT D+L
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALR-RQGAEAWLKAKQGKTLDFIDVL 309
Query: 202 LKGLDDEA--FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L D++ +D++IR E DT +F G DT+S ++ ++ L YPE Q+K +EI+ V
Sbjct: 310 LLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVM 369
Query: 260 -GDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCML 317
G +++ +L +T +KE+LR YP +V R+ +IKL IP C++
Sbjct: 370 KGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLV 429
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
IYG + +P PD+ + P R+ P A+ FS G RNCIG+++A+ ++ +
Sbjct: 430 SIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVV 489
Query: 378 VHLLRRYKVTAD-ISKIEFKLDALMVPSDNCYAKFE 412
L R++++ D K+ K + ++ + + K E
Sbjct: 490 ALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVE 525
>BC093896-1|AAH93896.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 185 bits (451), Expect = 2e-46
Identities = 119/396 (30%), Positives = 202/396 (51%), Gaps = 10/396 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMK 84
FY F WLGDGL+ S G+ W RHR+LL PAF +L Y +FN +S +++ A +
Sbjct: 132 FYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFN-QSADIMHAKWRHLA 190
Query: 85 SGPVLISAAFKE---MALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
G + F+ M L +L F + Y+ A+ E+ A+ RR + +
Sbjct: 191 EGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y SA ++ + + + + +VI +RRAL+ +Q + A + KT D+L
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALR-QQGAEAWLKAKQGKTLDFIDVL 309
Query: 202 LKGLDDEA--FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L D++ +D++IR E DT +F G DT+S ++ ++ L YPE Q+K +EI+ V
Sbjct: 310 LLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVM 369
Query: 260 -GDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCML 317
G +++ +L +T +KE+LR YP +V R+ +IKL IP C++
Sbjct: 370 KGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLV 429
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
IYG + +P PD+ + P R+ P A+ FS G RNCIG+++A+ ++ +
Sbjct: 430 SIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVV 489
Query: 378 VHLLRRYKVTAD-ISKIEFKLDALMVPSDNCYAKFE 412
L R++++ D K+ K + ++ + + K E
Sbjct: 490 ALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVE 525
>BC093894-1|AAH93894.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 185 bits (451), Expect = 2e-46
Identities = 119/396 (30%), Positives = 202/396 (51%), Gaps = 10/396 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMK 84
FY F WLGDGL+ S G+ W RHR+LL PAF +L Y +FN +S +++ A +
Sbjct: 132 FYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFN-QSADIMHAKWRHLA 190
Query: 85 SGPVLISAAFKE---MALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
G + F+ M L +L F + Y+ A+ E+ A+ RR + +
Sbjct: 191 EGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y SA ++ + + + + +VI +RRAL+ +Q + A + KT D+L
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALR-QQGAEAWLKAKQGKTLDFIDVL 309
Query: 202 LKGLDDEA--FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L D++ +D++IR E DT +F G DT+S ++ ++ L YPE Q+K +EI+ V
Sbjct: 310 LLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVM 369
Query: 260 -GDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCML 317
G +++ +L +T +KE+LR YP +V R+ +IKL IP C++
Sbjct: 370 KGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLV 429
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
IYG + +P PD+ + P R+ P A+ FS G RNCIG+++A+ ++ +
Sbjct: 430 SIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVV 489
Query: 378 VHLLRRYKVTAD-ISKIEFKLDALMVPSDNCYAKFE 412
L R++++ D K+ K + ++ + + K E
Sbjct: 490 ALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVE 525
>BC069351-1|AAH69351.1| 531|Homo sapiens cytochrome P450, family 2,
subfamily E, polypeptide 2 homolog protein.
Length = 531
Score = 185 bits (451), Expect = 2e-46
Identities = 119/396 (30%), Positives = 202/396 (51%), Gaps = 10/396 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMK 84
FY F WLGDGL+ S G+ W RHR+LL PAF +L Y +FN +S +++ A +
Sbjct: 132 FYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFN-QSADIMHAKWRHLA 190
Query: 85 SGPVLISAAFKE---MALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
G + F+ M L +L F + Y+ A+ E+ A+ RR + +
Sbjct: 191 EGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHY 250
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y SA ++ + + + + +VI +RRAL+ +Q + A + KT D+L
Sbjct: 251 LDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALR-QQGAEAWLKAKQGKTLDFIDVL 309
Query: 202 LKGLDDEA--FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L D++ +D++IR E DT +F G DT+S ++ ++ L YPE Q+K +EI+ V
Sbjct: 310 LLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVM 369
Query: 260 -GDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCML 317
G +++ +L +T +KE+LR YP +V R+ +IKL IP C++
Sbjct: 370 KGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLV 429
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
IYG + +P PD+ + P R+ P A+ FS G RNCIG+++A+ ++ +
Sbjct: 430 SIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVV 489
Query: 378 VHLLRRYKVTAD-ISKIEFKLDALMVPSDNCYAKFE 412
L R++++ D K+ K + ++ + + K E
Sbjct: 490 ALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVE 525
>D12620-1|BAA02144.1| 520|Homo sapiens cytochrome P-450LTBV
protein.
Length = 520
Score = 184 bits (449), Expect = 4e-46
Identities = 115/372 (30%), Positives = 189/372 (50%), Gaps = 8/372 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQM 83
FY F WLGDGL+ S+GE W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 124 FYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLLA 182
Query: 84 KSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
G + M L +L F + + +Y+ A+ E+ A++T+R Q ILL+
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLY 242
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+L
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 202 L--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 303 LLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362
Query: 260 GDSD-ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCML 317
D + +++ +L + +KE+LRL+P P V R +I L IP C++
Sbjct: 363 KDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLI 422
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
++G + +P PD + P R+ P AF FS G RNCIG+ +A+ MK L
Sbjct: 423 SVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 378 VHLLRRYKVTAD 389
L ++V D
Sbjct: 483 GLTLLAFRVLPD 494
>AB002461-1|BAA25991.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 184 bits (449), Expect = 4e-46
Identities = 115/372 (30%), Positives = 189/372 (50%), Gaps = 8/372 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQM 83
FY F WLGDGL+ S+GE W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 124 FYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLLA 182
Query: 84 KSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
G + M L +L F + + +Y+ A+ E+ A++T+R Q ILL+
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLY 242
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+L
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 202 L--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 303 LLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362
Query: 260 GDSD-ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCML 317
D + +++ +L + +KE+LRL+P P V R +I L IP C++
Sbjct: 363 KDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLI 422
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
++G + +P PD + P R+ P AF FS G RNCIG+ +A+ MK L
Sbjct: 423 SVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 378 VHLLRRYKVTAD 389
L ++V D
Sbjct: 483 GLTLLAFRVLPD 494
>AB002454-1|BAA25990.1| 520|Homo sapiens leukotriene B4
omega-hydroxylase protein.
Length = 520
Score = 184 bits (449), Expect = 4e-46
Identities = 115/372 (30%), Positives = 189/372 (50%), Gaps = 8/372 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQM 83
FY F WLGDGL+ S+GE W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 124 FYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLLA 182
Query: 84 KSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
G + M L +L F + + +Y+ A+ E+ A++T+R Q ILL+
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLY 242
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+L
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 202 L--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 303 LLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362
Query: 260 GDSD-ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCML 317
D + +++ +L + +KE+LRL+P P V R +I L IP C++
Sbjct: 363 KDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLI 422
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
++G + +P PD + P R+ P AF FS G RNCIG+ +A+ MK L
Sbjct: 423 SVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
Query: 378 VHLLRRYKVTAD 389
L ++V D
Sbjct: 483 GLTLLAFRVLPD 494
>BC035350-1|AAH35350.1| 524|Homo sapiens cytochrome P450, family 4,
subfamily F, polypeptide 12 protein.
Length = 524
Score = 184 bits (447), Expect = 7e-46
Identities = 114/409 (27%), Positives = 201/409 (49%), Gaps = 8/409 (1%)
Query: 12 NLTVANGAL--HKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFN 69
++T A+ A+ + F +F WLG+G++ S G+ W RHR++L PAF +L Y +FN
Sbjct: 109 SITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFN 168
Query: 70 RESRNLISAIEIQMKSGPVLISAA--FKEMALKALLSTAFGIEVEECDFNQKYMHAVDEV 127
+ + ++ + G + M L +L F + + +Y+ + E+
Sbjct: 169 KSANIMLDKWQHLASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILEL 228
Query: 128 MAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG 187
A++ +R Q+IL H F+Y LS ++ + ++ VI +RR L +
Sbjct: 229 SALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFK 288
Query: 188 CASEKKTQSMSDLLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYP 245
++ KT D+LL K D +A +D++IR E DT +F G DT++ ++ V+ L +P
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 246 EIQDKVYQEIKSVCGDSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL 304
E Q++ QE++ + D D +++ +L + +KE+LRL+P P + R +I L
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 305 KS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNC 363
IP C++ I G++ +P PD + P R+ P AF FS G RNC
Sbjct: 409 PDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNC 468
Query: 364 IGKTYALISMKTTLVHLLRRYKVTADISKIEFKLDALMVPSDNCYAKFE 412
IG+ +A+ MK L +L ++ D ++ KL+ +M + + E
Sbjct: 469 IGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
>AC004523-1|AAC11543.1| 458|Homo sapiens F22329_1 protein.
Length = 458
Score = 184 bits (447), Expect = 7e-46
Identities = 114/409 (27%), Positives = 201/409 (49%), Gaps = 8/409 (1%)
Query: 12 NLTVANGAL--HKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFN 69
++T A+ A+ + F +F WLG+G++ S G+ W RHR++L PAF +L Y +FN
Sbjct: 43 SITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFN 102
Query: 70 RESRNLISAIEIQMKSGPVLISAA--FKEMALKALLSTAFGIEVEECDFNQKYMHAVDEV 127
+ + ++ + G + M L +L F + + +Y+ + E+
Sbjct: 103 KSANIMLDKWQHLASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILEL 162
Query: 128 MAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG 187
A++ +R Q+IL H F+Y LS ++ + ++ VI +RR L +
Sbjct: 163 SALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFK 222
Query: 188 CASEKKTQSMSDLLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYP 245
++ KT D+LL K D +A +D++IR E DT +F G DT++ ++ V+ L +P
Sbjct: 223 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 282
Query: 246 EIQDKVYQEIKSVCGDSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL 304
E Q++ QE++ + D D +++ +L + +KE+LRL+P P + R +I L
Sbjct: 283 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 342
Query: 305 KS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNC 363
IP C++ I G++ +P PD + P R+ P AF FS G RNC
Sbjct: 343 PDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNC 402
Query: 364 IGKTYALISMKTTLVHLLRRYKVTADISKIEFKLDALMVPSDNCYAKFE 412
IG+ +A+ MK L +L ++ D ++ KL+ +M + + E
Sbjct: 403 IGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 451
>AY358977-1|AAQ89336.1| 524|Homo sapiens CYP4F12 protein.
Length = 524
Score = 183 bits (446), Expect = 9e-46
Identities = 114/409 (27%), Positives = 201/409 (49%), Gaps = 8/409 (1%)
Query: 12 NLTVANGAL--HKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFN 69
++T A+ A+ + F +F WLG+G++ S G+ W RHR++L PAF +L Y +FN
Sbjct: 109 SITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFN 168
Query: 70 RESRNLISAIEIQMKSGPVLISAA--FKEMALKALLSTAFGIEVEECDFNQKYMHAVDEV 127
+ + ++ + G + M L +L F + + +Y+ + E+
Sbjct: 169 KSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILEL 228
Query: 128 MAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG 187
A++ +R Q+IL H F+Y LS ++ + ++ VI +RR L +
Sbjct: 229 SALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFK 288
Query: 188 CASEKKTQSMSDLLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYP 245
++ KT D+LL K D +A +D++IR E DT +F G DT++ ++ V+ L +P
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 246 EIQDKVYQEIKSVCGDSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL 304
E Q++ QE++ + D D +++ +L + +KE+LRL+P P + R +I L
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 305 KS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNC 363
IP C++ I G++ +P PD + P R+ P AF FS G RNC
Sbjct: 409 PDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNC 468
Query: 364 IGKTYALISMKTTLVHLLRRYKVTADISKIEFKLDALMVPSDNCYAKFE 412
IG+ +A+ MK L +L ++ D ++ KL+ +M + + E
Sbjct: 469 IGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
>AY008841-1|AAG33247.1| 524|Homo sapiens cytochrome P450 isoform
4F12 protein.
Length = 524
Score = 183 bits (446), Expect = 9e-46
Identities = 114/409 (27%), Positives = 201/409 (49%), Gaps = 8/409 (1%)
Query: 12 NLTVANGAL--HKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFN 69
++T A+ A+ + F +F WLG+G++ S G+ W RHR++L PAF +L Y +FN
Sbjct: 109 SITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFN 168
Query: 70 RESRNLISAIEIQMKSGPVLISAA--FKEMALKALLSTAFGIEVEECDFNQKYMHAVDEV 127
+ + ++ + G + M L +L F + + +Y+ + E+
Sbjct: 169 KSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILEL 228
Query: 128 MAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG 187
A++ +R Q+IL H F+Y LS ++ + ++ VI +RR L +
Sbjct: 229 SALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFK 288
Query: 188 CASEKKTQSMSDLLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYP 245
++ KT D+LL K D +A +D++IR E DT +F G DT++ ++ V+ L +P
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 246 EIQDKVYQEIKSVCGDSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL 304
E Q++ QE++ + D D +++ +L + +KE+LRL+P P + R +I L
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 305 KS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNC 363
IP C++ I G++ +P PD + P R+ P AF FS G RNC
Sbjct: 409 PDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNC 468
Query: 364 IGKTYALISMKTTLVHLLRRYKVTADISKIEFKLDALMVPSDNCYAKFE 412
IG+ +A+ MK L +L ++ D ++ KL+ +M + + E
Sbjct: 469 IGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
>AB035131-1|BAB18270.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 183 bits (446), Expect = 9e-46
Identities = 114/409 (27%), Positives = 201/409 (49%), Gaps = 8/409 (1%)
Query: 12 NLTVANGAL--HKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFN 69
++T A+ A+ + F +F WLG+G++ S G+ W RHR++L PAF +L Y +FN
Sbjct: 109 SITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFN 168
Query: 70 RESRNLISAIEIQMKSGPVLISAA--FKEMALKALLSTAFGIEVEECDFNQKYMHAVDEV 127
+ + ++ + G + M L +L F + + +Y+ + E+
Sbjct: 169 KSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILEL 228
Query: 128 MAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG 187
A++ +R Q+IL H F+Y LS ++ + ++ VI +RR L +
Sbjct: 229 SALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFK 288
Query: 188 CASEKKTQSMSDLLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYP 245
++ KT D+LL K D +A +D++IR E DT +F G DT++ ++ V+ L +P
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 246 EIQDKVYQEIKSVCGDSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL 304
E Q++ QE++ + D D +++ +L + +KE+LRL+P P + R +I L
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 305 KS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNC 363
IP C++ I G++ +P PD + P R+ P AF FS G RNC
Sbjct: 409 PDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNC 468
Query: 364 IGKTYALISMKTTLVHLLRRYKVTADISKIEFKLDALMVPSDNCYAKFE 412
IG+ +A+ MK L +L ++ D ++ KL+ +M + + E
Sbjct: 469 IGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
>AB035130-1|BAB18269.1| 524|Homo sapiens cytochrome P450 protein.
Length = 524
Score = 183 bits (446), Expect = 9e-46
Identities = 114/409 (27%), Positives = 201/409 (49%), Gaps = 8/409 (1%)
Query: 12 NLTVANGAL--HKHFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFN 69
++T A+ A+ + F +F WLG+G++ S G+ W RHR++L PAF +L Y +FN
Sbjct: 109 SITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFN 168
Query: 70 RESRNLISAIEIQMKSGPVLISAA--FKEMALKALLSTAFGIEVEECDFNQKYMHAVDEV 127
+ + ++ + G + M L +L F + + +Y+ + E+
Sbjct: 169 KSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILEL 228
Query: 128 MAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENG 187
A++ +R Q+IL H F+Y LS ++ + ++ VI +RR L +
Sbjct: 229 SALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFK 288
Query: 188 CASEKKTQSMSDLLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYP 245
++ KT D+LL K D +A +D++IR E DT +F G DT++ ++ V+ L +P
Sbjct: 289 DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP 348
Query: 246 EIQDKVYQEIKSVCGDSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL 304
E Q++ QE++ + D D +++ +L + +KE+LRL+P P + R +I L
Sbjct: 349 EYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVL 408
Query: 305 KS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNC 363
IP C++ I G++ +P PD + P R+ P AF FS G RNC
Sbjct: 409 PDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNC 468
Query: 364 IGKTYALISMKTTLVHLLRRYKVTADISKIEFKLDALMVPSDNCYAKFE 412
IG+ +A+ MK L +L ++ D ++ KL+ +M + + E
Sbjct: 469 IGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVE 517
>BC016853-1|AAH16853.1| 524|Homo sapiens CYP4F11 protein protein.
Length = 524
Score = 178 bits (433), Expect = 3e-44
Identities = 109/368 (29%), Positives = 182/368 (49%), Gaps = 6/368 (1%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMK 84
FY F WLGDGL+ S G+ W RHR++L PAF +L Y +FN+ + +
Sbjct: 124 FYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLAS 183
Query: 85 SGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHN 142
G + M L +L F E + +Y+ A+ E+ A + +R Q ILLH
Sbjct: 184 EGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHT 243
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
F+Y L+ ++ + ++ VI +RR L + ++ KT D+LL
Sbjct: 244 DFLYYLTPDGQRFRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLL 303
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 304 LSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLK 363
Query: 261 DSD-ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLR-KTENEIKLKSYTIPANSNCMLG 318
D + +++ +L + +KE+LRL+P PV+ R T++ + IP C++
Sbjct: 364 DREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLIN 423
Query: 319 IYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
I G++ +P PD + P R+ + P AF FS G RNCIG+ +A+ MK L
Sbjct: 424 IIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLA 483
Query: 379 HLLRRYKV 386
L +++
Sbjct: 484 LTLLHFRI 491
>AF236085-1|AAG15889.1| 524|Homo sapiens CYP4F11 protein.
Length = 524
Score = 178 bits (433), Expect = 3e-44
Identities = 109/368 (29%), Positives = 182/368 (49%), Gaps = 6/368 (1%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMK 84
FY F WLGDGL+ S G+ W RHR++L PAF +L Y +FN+ + +
Sbjct: 124 FYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLAS 183
Query: 85 SGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHN 142
G + M L +L F E + +Y+ A+ E+ A + +R Q ILLH
Sbjct: 184 EGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHT 243
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
F+Y L+ ++ + ++ VI +RR L + ++ KT D+LL
Sbjct: 244 DFLYYLTPDGQRFRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLL 303
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 304 LSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLK 363
Query: 261 DSD-ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLR-KTENEIKLKSYTIPANSNCMLG 318
D + +++ +L + +KE+LRL+P PV+ R T++ + IP C++
Sbjct: 364 DREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLIN 423
Query: 319 IYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
I G++ +P PD + P R+ + P AF FS G RNCIG+ +A+ MK L
Sbjct: 424 IIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLA 483
Query: 379 HLLRRYKV 386
L +++
Sbjct: 484 LTLLHFRI 491
>X16699-1|CAA34672.1| 511|Homo sapiens protein ( Human mRNA for
cytochrome P-450HP. ).
Length = 511
Score = 171 bits (417), Expect = 3e-42
Identities = 110/387 (28%), Positives = 186/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGI-EVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNS 143
G I MAL L+ FG + + Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 144 FVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL- 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLG 291
Query: 203 -KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD
Sbjct: 292 ARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGD 351
Query: 262 SDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGI 319
D D L ++ Y +KE+ RLYP P V R+ + + ++PA S + I
Sbjct: 352 QDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHI 409
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
Y L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 YALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAM 469
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 CLLRFEFSLDPSRLPIKMPQLVLRSKN 496
>J02871-1|AAA35712.1| 511|Homo sapiens protein ( Human lung
cytochrome P450 (IV subfamily) BI protein, complete cds.
).
Length = 511
Score = 171 bits (417), Expect = 3e-42
Identities = 110/387 (28%), Positives = 186/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGI-EVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNS 143
G I MAL L+ FG + + Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 144 FVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL- 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLG 291
Query: 203 -KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD
Sbjct: 292 ARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGD 351
Query: 262 SDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGI 319
D D L ++ Y +KE+ RLYP P V R+ + + ++PA S + I
Sbjct: 352 QDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHI 409
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
Y L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 YALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAM 469
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 CLLRFEFSLDPSRLPIKMPQLVLRSKN 496
>DQ518907-1|ABF47106.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 171 bits (417), Expect = 3e-42
Identities = 110/387 (28%), Positives = 186/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGI-EVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNS 143
G I MAL L+ FG + + Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 144 FVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL- 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLG 291
Query: 203 -KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD
Sbjct: 292 ARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGD 351
Query: 262 SDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGI 319
D D L ++ Y +KE+ RLYP P V R+ + + ++PA S + I
Sbjct: 352 QDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHI 409
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
Y L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 YALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAM 469
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 CLLRFEFSLDPSRLPIKMPQLVLRSKN 496
>AL593856-5|CAI16981.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 171 bits (417), Expect = 3e-42
Identities = 110/387 (28%), Positives = 186/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGI-EVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNS 143
G I MAL L+ FG + + Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 144 FVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL- 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLG 291
Query: 203 -KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD
Sbjct: 292 ARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGD 351
Query: 262 SDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGI 319
D D L ++ Y +KE+ RLYP P V R+ + + ++PA S + I
Sbjct: 352 QDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHI 409
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
Y L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 YALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAM 469
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 CLLRFEFSLDPSRLPIKMPQLVLRSKN 496
>AL356793-4|CAI22559.1| 511|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 511
Score = 171 bits (417), Expect = 3e-42
Identities = 110/387 (28%), Positives = 186/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGI-EVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNS 143
G I MAL L+ FG + + Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 144 FVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL- 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLG 291
Query: 203 -KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD
Sbjct: 292 ARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGD 351
Query: 262 SDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGI 319
D D L ++ Y +KE+ RLYP P V R+ + + ++PA S + I
Sbjct: 352 QDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHI 409
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
Y L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 YALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAM 469
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 CLLRFEFSLDPSRLPIKMPQLVLRSKN 496
>AF491285-1|AAM09532.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 171 bits (417), Expect = 3e-42
Identities = 110/387 (28%), Positives = 186/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGI-EVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNS 143
G I MAL L+ FG + + Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 144 FVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL- 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLG 291
Query: 203 -KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD
Sbjct: 292 ARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCIALYPEHQHRCREEVREILGD 351
Query: 262 SDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGI 319
D D L ++ Y +KE+ RLYP P V R+ + + ++PA S + I
Sbjct: 352 QDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHI 409
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
Y L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 YALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAM 469
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 CLLRFEFSLDPSRLPIKMPQLVLRSKN 496
>BC017758-1|AAH17758.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 171 bits (415), Expect = 5e-42
Identities = 110/388 (28%), Positives = 186/388 (47%), Gaps = 12/388 (3%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIEVEECDFNQ--KYMHAVDEVMAVLTRRFQNILLHN 142
G I MAL L+ FG ++ Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILL 291
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + G
Sbjct: 292 GARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG 351
Query: 261 DSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLG 318
D D D L ++ Y +KE+ RLYP P V R+ + + ++PA S +
Sbjct: 352 DQDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMH 409
Query: 319 IYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
IY L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 IYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTA 469
Query: 379 HLLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 MCLLRFEFSLDPSRLPIKMPQLVLRSKN 497
>AY151048-1|AAN72311.1| 512|Homo sapiens pulmonary cytochrome P450
4B1 protein.
Length = 512
Score = 171 bits (415), Expect = 5e-42
Identities = 110/388 (28%), Positives = 186/388 (47%), Gaps = 12/388 (3%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIEVEECDFNQ--KYMHAVDEVMAVLTRRFQNILLHN 142
G I MAL L+ FG ++ Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILL 291
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + G
Sbjct: 292 GARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG 351
Query: 261 DSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLG 318
D D D L ++ Y +KE+ RLYP P V R+ + + ++PA S +
Sbjct: 352 DQDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMH 409
Query: 319 IYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
IY L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 IYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTA 469
Query: 379 HLLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 MCLLRFEFSLDPSRLPIKMPQLVLRSKN 497
>AY064486-1|AAL57721.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 171 bits (415), Expect = 5e-42
Identities = 110/387 (28%), Positives = 186/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGI-EVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNS 143
G I MAL L+ FG + + Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 144 FVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL- 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLG 291
Query: 203 -KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD
Sbjct: 292 ARDEDDIKLSDADLRAEVDTFMFEGHDTTTGGISWFLYCMALYPEHQHRCREEVREILGD 351
Query: 262 SDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGI 319
D D L ++ Y +KE+ RLYP P V R+ + + ++PA S + I
Sbjct: 352 QDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHI 409
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
Y L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 YALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAM 469
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 CLLRFEFSLDPSRLPIKMPQLVLRSKN 496
>AL593856-6|CAI16982.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 171 bits (415), Expect = 5e-42
Identities = 110/388 (28%), Positives = 186/388 (47%), Gaps = 12/388 (3%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIEVEECDFNQ--KYMHAVDEVMAVLTRRFQNILLHN 142
G I MAL L+ FG ++ Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILL 291
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + G
Sbjct: 292 GARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG 351
Query: 261 DSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLG 318
D D D L ++ Y +KE+ RLYP P V R+ + + ++PA S +
Sbjct: 352 DQDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMH 409
Query: 319 IYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
IY L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 IYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTA 469
Query: 379 HLLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 MCLLRFEFSLDPSRLPIKMPQLVLRSKN 497
>AL356793-3|CAI22557.1| 512|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 512
Score = 171 bits (415), Expect = 5e-42
Identities = 110/388 (28%), Positives = 186/388 (47%), Gaps = 12/388 (3%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E + +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKARE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIEVEECDFNQ--KYMHAVDEVMAVLTRRFQNILLHN 142
G I MAL L+ FG ++ Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN 234
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 DFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILL 291
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + G
Sbjct: 292 GARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG 351
Query: 261 DSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLG 318
D D D L ++ Y +KE+ RLYP P V R+ + + ++PA S +
Sbjct: 352 DQDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMH 409
Query: 319 IYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
IY L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 IYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTA 469
Query: 379 HLLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 MCLLRFEFSLDPSRLPIKMPQLVLRSKN 497
>AF133298-1|AAD49566.1| 520|Homo sapiens cytochrome P450 protein.
Length = 520
Score = 170 bits (413), Expect = 9e-42
Identities = 106/372 (28%), Positives = 183/372 (49%), Gaps = 8/372 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAI--EIQ 82
FY+ WLGDGL+ S G+ W+ HR+LL PAF +L Y +F++ S N++ A +
Sbjct: 124 FYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSK-SANIMHAKWQRLA 182
Query: 83 MKSGPVL-ISAAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
M+ L + M L +L F + + +Y+ A+ E+ A++ +R +
Sbjct: 183 MEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRY 242
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+L
Sbjct: 243 KDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 202 LKGLDDEA--FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L D +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 303 LLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELL 362
Query: 260 GDSDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLK-SYTIPANSNCML 317
D + +++ +L + LKE+LRL+P P R ++ L S IP + C +
Sbjct: 363 KDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNI 422
Query: 318 GIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTL 377
I+ ++ +P PD + P R+ P AF FS G RNCIG+ +A+ MK L
Sbjct: 423 NIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVL 482
Query: 378 VHLLRRYKVTAD 389
L R+++ D
Sbjct: 483 ALTLLRFRILPD 494
>AY064485-1|AAL57720.1| 511|Homo sapiens cytochrome P450 protein.
Length = 511
Score = 169 bits (412), Expect = 1e-41
Identities = 110/387 (28%), Positives = 185/387 (47%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
Y F W+G GL+ G W +HRKLL P F +L Y VF +R ++ E +
Sbjct: 115 YDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAWE 174
Query: 86 GPVL-ISAAFKEMALKALLSTAFGI-EVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNS 143
G I MAL L+ FG + + Y AV ++ ++ +R + HN
Sbjct: 175 GKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHND 234
Query: 144 FVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL- 202
F+Y L+ ++ + +++VI ++ AL++++ + ++ D+LL
Sbjct: 235 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLG 291
Query: 203 -KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
+ DD +D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD
Sbjct: 292 ARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGD 351
Query: 262 SDA-DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGI 319
D D L ++ Y +KE+ RLYP P V R+ + + ++PA S + I
Sbjct: 352 QDFFQWDDLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHI 409
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
Y L+R+ PD F R+ P AF FS G RNCIG+ +A+ MK
Sbjct: 410 YALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAM 469
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R++ + D S++ K+ L++ S N
Sbjct: 470 CLLRFEFSLDPSRLPIKMPQLVLRSKN 496
>S67580-1|AAB29502.1| 519|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 519
Score = 165 bits (401), Expect = 3e-40
Identities = 107/390 (27%), Positives = 194/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++I + L++ S N
Sbjct: 471 TALTLLRFELLPDPTRIPIPIARLVLKSKN 500
>L04751-1|AAA58436.1| 519|Homo sapiens cytochrome P450 protein.
Length = 519
Score = 164 bits (398), Expect = 6e-40
Identities = 107/390 (27%), Positives = 194/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++I + L++ S N
Sbjct: 471 TALTLLRFELLPDPTRIPIPIARLVLKSKN 500
>D26481-1|BAA05491.1| 519|Homo sapiens fatty acids
omega-hydroxylase protein.
Length = 519
Score = 164 bits (398), Expect = 6e-40
Identities = 107/390 (27%), Positives = 194/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++I + L++ S N
Sbjct: 471 TALTLLRFELLPDPTRIPIPIARLVLKSKN 500
>AY369778-1|AAQ56847.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 164 bits (398), Expect = 6e-40
Identities = 107/390 (27%), Positives = 194/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++I + L++ S N
Sbjct: 471 TALTLLRFELLPDPTRIPIPIARLVLKSKN 500
>AL731892-3|CAH72778.1| 519|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 519
Score = 164 bits (398), Expect = 6e-40
Identities = 107/390 (27%), Positives = 194/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++I + L++ S N
Sbjct: 471 TALTLLRFELLPDPTRIPIPIARLVLKSKN 500
>S67581-1|AAB29503.1| 591|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 591
Score = 163 bits (396), Expect = 1e-39
Identities = 106/388 (27%), Positives = 193/388 (49%), Gaps = 12/388 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPS 404
L R+++ D ++I + L++ S
Sbjct: 471 TALTLLRFELLPDPTRIPIPIARLVLKS 498
>AY358631-1|AAQ88994.1| 505|Homo sapiens EPSW3060 protein.
Length = 505
Score = 163 bits (396), Expect = 1e-39
Identities = 102/387 (26%), Positives = 188/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
++ +W+G GLVT G WK+HR+++ P F+ +L I+ + + R +++ E +
Sbjct: 114 HKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQ 173
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIE--VEECDFNQKYMHAVDEVMAVLTRRFQNILLHN 142
L + M L +++ AF + ++ Y+ AV + + +R N L HN
Sbjct: 174 NSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHN 233
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
V+K S+ + + + + + KVI ++ +LK+K + ++K+ D+LL
Sbjct: 234 DLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQD----TTQKRRWDFLDILL 289
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
K + + F++ +++ EV T +F G DT+S ++ ++ L YPE Q + EI+ + G
Sbjct: 290 SAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG 349
Query: 261 DSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKS-YTIPANSNCMLGI 319
D + + ++ YT +KE LRLY + R + I ++PA + I
Sbjct: 350 DGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINI 408
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
+ L+ +P + D F P R+ P AF FS G RNCIG+ +A+I K +
Sbjct: 409 WALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVAL 468
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R+K+ D S+ + +++ S N
Sbjct: 469 TLLRFKLAPDHSRPPQPVRQVVLKSKN 495
>AY262056-1|AAO89257.1| 505|Homo sapiens cytochrome P450 protein.
Length = 505
Score = 163 bits (396), Expect = 1e-39
Identities = 102/387 (26%), Positives = 188/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
++ +W+G GLVT G WK+HR+++ P F+ +L I+ + + R +++ E +
Sbjct: 114 HKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQ 173
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIE--VEECDFNQKYMHAVDEVMAVLTRRFQNILLHN 142
L + M L +++ AF + ++ Y+ AV + + +R N L HN
Sbjct: 174 NSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHN 233
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
V+K S+ + + + + + KVI ++ +LK+K + ++K+ D+LL
Sbjct: 234 DLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQD----TTQKRRWDFLDILL 289
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
K + + F++ +++ EV T +F G DT+S ++ ++ L YPE Q + EI+ + G
Sbjct: 290 SAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG 349
Query: 261 DSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKS-YTIPANSNCMLGI 319
D + + ++ YT +KE LRLY + R + I ++PA + I
Sbjct: 350 DGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINI 408
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
+ L+ +P + D F P R+ P AF FS G RNCIG+ +A+I K +
Sbjct: 409 WALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVAL 468
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R+K+ D S+ + +++ S N
Sbjct: 469 TLLRFKLAPDHSRPPQPVRQVVLKSKN 495
>AL450996-2|CAH71036.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 163 bits (396), Expect = 1e-39
Identities = 102/387 (26%), Positives = 188/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
++ +W+G GLVT G WK+HR+++ P F+ +L I+ + + R +++ E +
Sbjct: 114 HKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQ 173
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIE--VEECDFNQKYMHAVDEVMAVLTRRFQNILLHN 142
L + M L +++ AF + ++ Y+ AV + + +R N L HN
Sbjct: 174 NSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHN 233
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
V+K S+ + + + + + KVI ++ +LK+K + ++K+ D+LL
Sbjct: 234 DLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQD----TTQKRRWDFLDILL 289
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
K + + F++ +++ EV T +F G DT+S ++ ++ L YPE Q + EI+ + G
Sbjct: 290 SAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG 349
Query: 261 DSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKS-YTIPANSNCMLGI 319
D + + ++ YT +KE LRLY + R + I ++PA + I
Sbjct: 350 DGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINI 408
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
+ L+ +P + D F P R+ P AF FS G RNCIG+ +A+I K +
Sbjct: 409 WALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVAL 468
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R+K+ D S+ + +++ S N
Sbjct: 469 TLLRFKLAPDHSRPPQPVRQVVLKSKN 495
>AL135960-6|CAI19734.1| 505|Homo sapiens cytochrome P450, family 4,
subfamily Z, polypeptide 1 protein.
Length = 505
Score = 163 bits (396), Expect = 1e-39
Identities = 102/387 (26%), Positives = 188/387 (48%), Gaps = 11/387 (2%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
++ +W+G GLVT G WK+HR+++ P F+ +L I+ + + R +++ E +
Sbjct: 114 HKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQ 173
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIE--VEECDFNQKYMHAVDEVMAVLTRRFQNILLHN 142
L + M L +++ AF + ++ Y+ AV + + +R N L HN
Sbjct: 174 NSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHN 233
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
V+K S+ + + + + + KVI ++ +LK+K + ++K+ D+LL
Sbjct: 234 DLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQD----TTQKRRWDFLDILL 289
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCG 260
K + + F++ +++ EV T +F G DT+S ++ ++ L YPE Q + EI+ + G
Sbjct: 290 SAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG 349
Query: 261 DSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKS-YTIPANSNCMLGI 319
D + + ++ YT +KE LRLY + R + I ++PA + I
Sbjct: 350 DGSS-ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINI 408
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
+ L+ +P + D F P R+ P AF FS G RNCIG+ +A+I K +
Sbjct: 409 WALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVAL 468
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDN 406
L R+K+ D S+ + +++ S N
Sbjct: 469 TLLRFKLAPDHSRPPQPVRQVVLKSKN 495
>AF525488-1|AAO16078.1| 519|Homo sapiens cytochrome P450, subfamily
IVA, polypeptide 11 protein.
Length = 519
Score = 162 bits (394), Expect = 2e-39
Identities = 106/390 (27%), Positives = 194/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRL+P P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLFPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++I + L++ S N
Sbjct: 471 TALTLLRFELLPDPTRIPIPIARLVLKSKN 500
>BC028102-1|AAH28102.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 162 bits (393), Expect = 2e-39
Identities = 107/413 (25%), Positives = 194/413 (46%), Gaps = 15/413 (3%)
Query: 6 ITDPEDNLTVANGALHKHFFYQ-FASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIY 64
I DP+ T+ + K + Q F+ LG GL G W +HR+LL P F +L Y
Sbjct: 93 IYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAY 152
Query: 65 TVVFNRESRNLISAIE--IQMKSGPVLISAAFKEMALKALLSTAFGIEVEECDFNQK--- 119
V + ++ E + V + M+L ++ AF E C N
Sbjct: 153 IEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETN-CQTNSTHDP 211
Query: 120 YMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKN 179
Y A+ E+ ++ R ++L H+ ++KLS + +L + ++ +I ++++L
Sbjct: 212 YAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSL-- 269
Query: 180 KQESHENGCASEKKTQSMSDLLLKGLDDE--AFTDKEIRNEVDTLIFTGSDTSSQIMTVV 237
Q + ++K Q D++L D+ +F+D ++ +EV T + G DT + ++ +
Sbjct: 270 -QAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWI 328
Query: 238 VMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRK 297
+ L PE Q++ +E++ + GD + + Q + YT +KET RL P P + R
Sbjct: 329 LYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRD 387
Query: 298 TENEIKLKS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGF 356
+ T+PA +L I+GL+ +P + F P R+ + P A+ F
Sbjct: 388 LSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPF 447
Query: 357 SVGKRNCIGKTYALISMKTTLVHLLRRYKVTADISK-IEFKLDALMVPSDNCY 408
S G RNCIG+ +A+I +K T+ +L ++VT D ++ + F ++ P + Y
Sbjct: 448 SAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMY 500
>AY358537-1|AAQ88901.1| 509|Homo sapiens EFSW1929 protein.
Length = 509
Score = 162 bits (393), Expect = 2e-39
Identities = 107/413 (25%), Positives = 194/413 (46%), Gaps = 15/413 (3%)
Query: 6 ITDPEDNLTVANGALHKHFFYQ-FASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIY 64
I DP+ T+ + K + Q F+ LG GL G W +HR+LL P F +L Y
Sbjct: 93 IYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAY 152
Query: 65 TVVFNRESRNLISAIE--IQMKSGPVLISAAFKEMALKALLSTAFGIEVEECDFNQK--- 119
V + ++ E + V + M+L ++ AF E C N
Sbjct: 153 IEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETN-CQTNSTHDP 211
Query: 120 YMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKN 179
Y A+ E+ ++ R ++L H+ ++KLS + +L + ++ +I ++++L
Sbjct: 212 YAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSL-- 269
Query: 180 KQESHENGCASEKKTQSMSDLLLKGLDDE--AFTDKEIRNEVDTLIFTGSDTSSQIMTVV 237
Q + ++K Q D++L D+ +F+D ++ +EV T + G DT + ++ +
Sbjct: 270 -QAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWI 328
Query: 238 VMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRK 297
+ L PE Q++ +E++ + GD + + Q + YT +KET RL P P + R
Sbjct: 329 LYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRD 387
Query: 298 TENEIKLKS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGF 356
+ T+PA +L I+GL+ +P + F P R+ + P A+ F
Sbjct: 388 LSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPF 447
Query: 357 SVGKRNCIGKTYALISMKTTLVHLLRRYKVTADISK-IEFKLDALMVPSDNCY 408
S G RNCIG+ +A+I +K T+ +L ++VT D ++ + F ++ P + Y
Sbjct: 448 SAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMY 500
>AY151049-1|AAN72312.1| 497|Homo sapiens pulmonary cytochrome P450
4B1 variant protein.
Length = 497
Score = 162 bits (393), Expect = 2e-39
Identities = 107/380 (28%), Positives = 182/380 (47%), Gaps = 12/380 (3%)
Query: 34 GDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVL-ISA 92
G GL+ G W +HRKLL P F +L Y VF +R ++ E + + G I
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 93 AFKEMALKALLSTAFGIEVEECDFNQ--KYMHAVDEVMAVLTRRFQNILLHNSFVYKLSA 150
MAL L+ FG ++ Y AV ++ ++ +R + HN F+Y L+
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 151 LKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL--KGLDDE 208
++ + +++VI ++ AL++++ + ++ D+LL + DD
Sbjct: 228 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLGARDEDDI 284
Query: 209 AFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDA-DVD 267
+D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD D D
Sbjct: 285 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWD 344
Query: 268 KLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGIYGLNRHP 326
L ++ Y +KE+ RLYP P V R+ + + ++PA S + IY L+R+
Sbjct: 345 DLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNS 402
Query: 327 VWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
PD F R+ P AF FS G RNCIG+ +A+ MK L R++
Sbjct: 403 AVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEF 462
Query: 387 TADISKIEFKLDALMVPSDN 406
+ D S++ K+ L++ S N
Sbjct: 463 SLDPSRLPIKMPQLVLRSKN 482
>AM040940-1|CAJ13826.1| 509|Homo sapiens cytochrome P450 protein.
Length = 509
Score = 162 bits (393), Expect = 2e-39
Identities = 107/413 (25%), Positives = 194/413 (46%), Gaps = 15/413 (3%)
Query: 6 ITDPEDNLTVANGALHKHFFYQ-FASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIY 64
I DP+ T+ + K + Q F+ LG GL G W +HR+LL P F +L Y
Sbjct: 93 IYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAY 152
Query: 65 TVVFNRESRNLISAIE--IQMKSGPVLISAAFKEMALKALLSTAFGIEVEECDFNQK--- 119
V + ++ E + V + M+L ++ AF E C N
Sbjct: 153 IEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETN-CQTNSTHDP 211
Query: 120 YMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKN 179
Y A+ E+ ++ R ++L H+ ++KLS + +L + ++ +I ++++L
Sbjct: 212 YAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSL-- 269
Query: 180 KQESHENGCASEKKTQSMSDLLLKGLDDE--AFTDKEIRNEVDTLIFTGSDTSSQIMTVV 237
Q + ++K Q D++L D+ +F+D ++ +EV T + G DT + ++ +
Sbjct: 270 -QAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWI 328
Query: 238 VMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRK 297
+ L PE Q++ +E++ + GD + + Q + YT +KET RL P P + R
Sbjct: 329 LYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRD 387
Query: 298 TENEIKLKS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGF 356
+ T+PA +L I+GL+ +P + F P R+ + P A+ F
Sbjct: 388 LSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPF 447
Query: 357 SVGKRNCIGKTYALISMKTTLVHLLRRYKVTADISK-IEFKLDALMVPSDNCY 408
S G RNCIG+ +A+I +K T+ +L ++VT D ++ + F ++ P + Y
Sbjct: 448 SAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMY 500
>AL593856-7|CAI16983.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 162 bits (393), Expect = 2e-39
Identities = 107/380 (28%), Positives = 182/380 (47%), Gaps = 12/380 (3%)
Query: 34 GDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVL-ISA 92
G GL+ G W +HRKLL P F +L Y VF +R ++ E + + G I
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 93 AFKEMALKALLSTAFGIEVEECDFNQ--KYMHAVDEVMAVLTRRFQNILLHNSFVYKLSA 150
MAL L+ FG ++ Y AV ++ ++ +R + HN F+Y L+
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 151 LKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL--KGLDDE 208
++ + +++VI ++ AL++++ + ++ D+LL + DD
Sbjct: 228 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLGARDEDDI 284
Query: 209 AFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDA-DVD 267
+D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD D D
Sbjct: 285 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWD 344
Query: 268 KLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGIYGLNRHP 326
L ++ Y +KE+ RLYP P V R+ + + ++PA S + IY L+R+
Sbjct: 345 DLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNS 402
Query: 327 VWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
PD F R+ P AF FS G RNCIG+ +A+ MK L R++
Sbjct: 403 AVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEF 462
Query: 387 TADISKIEFKLDALMVPSDN 406
+ D S++ K+ L++ S N
Sbjct: 463 SLDPSRLPIKMPQLVLRSKN 482
>AL450996-1|CAH71035.1| 509|Homo sapiens cytochrome P450, family 4,
subfamily X, polypeptide 1 protein.
Length = 509
Score = 162 bits (393), Expect = 2e-39
Identities = 107/413 (25%), Positives = 194/413 (46%), Gaps = 15/413 (3%)
Query: 6 ITDPEDNLTVANGALHKHFFYQ-FASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIY 64
I DP+ T+ + K + Q F+ LG GL G W +HR+LL P F +L Y
Sbjct: 93 IYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAY 152
Query: 65 TVVFNRESRNLISAIE--IQMKSGPVLISAAFKEMALKALLSTAFGIEVEECDFNQK--- 119
V + ++ E + V + M+L ++ AF E C N
Sbjct: 153 IEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETN-CQTNSTHDP 211
Query: 120 YMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKN 179
Y A+ E+ ++ R ++L H+ ++KLS + +L + ++ +I ++++L
Sbjct: 212 YAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSL-- 269
Query: 180 KQESHENGCASEKKTQSMSDLLLKGLDDE--AFTDKEIRNEVDTLIFTGSDTSSQIMTVV 237
Q + ++K Q D++L D+ +F+D ++ +EV T + G DT + ++ +
Sbjct: 270 -QAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWI 328
Query: 238 VMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRK 297
+ L PE Q++ +E++ + GD + + Q + YT +KET RL P P + R
Sbjct: 329 LYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRD 387
Query: 298 TENEIKLKS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGF 356
+ T+PA +L I+GL+ +P + F P R+ + P A+ F
Sbjct: 388 LSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPF 447
Query: 357 SVGKRNCIGKTYALISMKTTLVHLLRRYKVTADISK-IEFKLDALMVPSDNCY 408
S G RNCIG+ +A+I +K T+ +L ++VT D ++ + F ++ P + Y
Sbjct: 448 SAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMY 500
>AL356793-2|CAI22558.1| 497|Homo sapiens cytochrome P450, family 4,
subfamily B, polypeptide 1 protein.
Length = 497
Score = 162 bits (393), Expect = 2e-39
Identities = 107/380 (28%), Positives = 182/380 (47%), Gaps = 12/380 (3%)
Query: 34 GDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVL-ISA 92
G GL+ G W +HRKLL P F +L Y VF +R ++ E + + G I
Sbjct: 108 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 167
Query: 93 AFKEMALKALLSTAFGIEVEECDFNQ--KYMHAVDEVMAVLTRRFQNILLHNSFVYKLSA 150
MAL L+ FG ++ Y AV ++ ++ +R + HN F+Y L+
Sbjct: 168 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 227
Query: 151 LKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL--KGLDDE 208
++ + +++VI ++ AL++++ + ++ D+LL + DD
Sbjct: 228 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK---IQNRRHLDFLDILLGARDEDDI 284
Query: 209 AFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDA-DVD 267
+D ++R EVDT +F G DT++ ++ + + YPE Q + +E++ + GD D D
Sbjct: 285 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWD 344
Query: 268 KLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIK-LKSYTIPANSNCMLGIYGLNRHP 326
L ++ Y +KE+ RLYP P V R+ + + ++PA S + IY L+R+
Sbjct: 345 DLG--KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNS 402
Query: 327 VWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
PD F R+ P AF FS G RNCIG+ +A+ MK L R++
Sbjct: 403 AVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEF 462
Query: 387 TADISKIEFKLDALMVPSDN 406
+ D S++ K+ L++ S N
Sbjct: 463 SLDPSRLPIKMPQLVLRSKN 482
>AK098065-1|BAC05226.1| 509|Homo sapiens protein ( Homo sapiens
cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 509
Score = 162 bits (393), Expect = 2e-39
Identities = 107/413 (25%), Positives = 194/413 (46%), Gaps = 15/413 (3%)
Query: 6 ITDPEDNLTVANGALHKHFFYQ-FASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIY 64
I DP+ T+ + K + Q F+ LG GL G W +HR+LL P F +L Y
Sbjct: 93 IYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAY 152
Query: 65 TVVFNRESRNLISAIE--IQMKSGPVLISAAFKEMALKALLSTAFGIEVEECDFNQK--- 119
V + ++ E + V + M+L ++ AF E C N
Sbjct: 153 IEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETN-CQTNSTHDP 211
Query: 120 YMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKN 179
Y A+ E+ ++ R ++L H+ ++KLS + +L + ++ +I ++++L
Sbjct: 212 YAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSL-- 269
Query: 180 KQESHENGCASEKKTQSMSDLLLKGLDDE--AFTDKEIRNEVDTLIFTGSDTSSQIMTVV 237
Q + ++K Q D++L D+ +F+D ++ +EV T + G DT + ++ +
Sbjct: 270 -QAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWI 328
Query: 238 VMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRK 297
+ L PE Q++ +E++ + GD + + Q + YT +KET RL P P + R
Sbjct: 329 LYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRD 387
Query: 298 TENEIKLKS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGF 356
+ T+PA +L I+GL+ +P + F P R+ + P A+ F
Sbjct: 388 LSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPF 447
Query: 357 SVGKRNCIGKTYALISMKTTLVHLLRRYKVTADISK-IEFKLDALMVPSDNCY 408
S G RNCIG+ +A+I +K T+ +L ++VT D ++ + F ++ P + Y
Sbjct: 448 SAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMY 500
>AK091806-1|BAC03751.1| 444|Homo sapiens protein ( Homo sapiens
cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 444
Score = 162 bits (393), Expect = 2e-39
Identities = 107/413 (25%), Positives = 194/413 (46%), Gaps = 15/413 (3%)
Query: 6 ITDPEDNLTVANGALHKHFFYQ-FASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIY 64
I DP+ T+ + K + Q F+ LG GL G W +HR+LL P F +L Y
Sbjct: 28 IYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAY 87
Query: 65 TVVFNRESRNLISAIE--IQMKSGPVLISAAFKEMALKALLSTAFGIEVEECDFNQK--- 119
V + ++ E + V + M+L ++ AF E C N
Sbjct: 88 IEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETN-CQTNSTHDP 146
Query: 120 YMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKN 179
Y A+ E+ ++ R ++L H+ ++KLS + +L + ++ +I ++++L
Sbjct: 147 YAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSL-- 204
Query: 180 KQESHENGCASEKKTQSMSDLLLKGLDDE--AFTDKEIRNEVDTLIFTGSDTSSQIMTVV 237
Q + ++K Q D++L D+ +F+D ++ +EV T + G DT + ++ +
Sbjct: 205 -QAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWI 263
Query: 238 VMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRK 297
+ L PE Q++ +E++ + GD + + Q + YT +KET RL P P + R
Sbjct: 264 LYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRD 322
Query: 298 TENEIKLKS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGF 356
+ T+PA +L I+GL+ +P + F P R+ + P A+ F
Sbjct: 323 LSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPF 382
Query: 357 SVGKRNCIGKTYALISMKTTLVHLLRRYKVTADISK-IEFKLDALMVPSDNCY 408
S G RNCIG+ +A+I +K T+ +L ++VT D ++ + F ++ P + Y
Sbjct: 383 SAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMY 435
>AY280372-1|AAQ21368.1| 519|Homo sapiens cytochrome P450 4A22
protein.
Length = 519
Score = 161 bits (392), Expect = 3e-39
Identities = 105/390 (26%), Positives = 193/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G L+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYKFLAPWIGYSLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ M L ++ +AF + + D N Q Y+ A+ ++ +++ R +N
Sbjct: 177 LGQDSPLEFFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLSSLVFCRMRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HENDAIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQTEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHG 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++I + L++ S N
Sbjct: 471 RALTLLRFELLPDPTRIPIPMARLVLKSKN 500
>AK131355-1|BAD18508.1| 508|Homo sapiens protein ( Homo sapiens
cDNA FLJ16384 fis, clone TLIVE2007607, weakly similar
to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
Length = 508
Score = 161 bits (392), Expect = 3e-39
Identities = 107/413 (25%), Positives = 194/413 (46%), Gaps = 15/413 (3%)
Query: 6 ITDPEDNLTVANGALHKHFFYQ-FASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIY 64
I DP+ T+ + K + Q F+ LG GL G W +HR+LL P F +L Y
Sbjct: 92 IYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAY 151
Query: 65 TVVFNRESRNLISAIE--IQMKSGPVLISAAFKEMALKALLSTAFGIEVEECDFNQK--- 119
V + ++ E + V + M+L ++ AF E C N
Sbjct: 152 IEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIVMKCAFSKETN-CQTNSTHDP 210
Query: 120 YMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKN 179
Y A+ E+ ++ R ++L H+ ++KLS + +L + ++ +I ++++L
Sbjct: 211 YAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSL-- 268
Query: 180 KQESHENGCASEKKTQSMSDLLLKGLDDE--AFTDKEIRNEVDTLIFTGSDTSSQIMTVV 237
Q + ++K Q D++L D+ +F+D ++ +EV T + G DT + ++ +
Sbjct: 269 -QAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWI 327
Query: 238 VMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRK 297
+ L PE Q++ +E++ + GD + + Q + YT +KET RL P P + R
Sbjct: 328 LYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMSYTTMCIKETCRLIPAVPSISRD 386
Query: 298 TENEIKLKS-YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGF 356
+ T+PA +L I+GL+ +P + F P R+ + P A+ F
Sbjct: 387 LSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPF 446
Query: 357 SVGKRNCIGKTYALISMKTTLVHLLRRYKVTADISK-IEFKLDALMVPSDNCY 408
S G RNCIG+ +A+I +K T+ +L ++VT D ++ + F ++ P + Y
Sbjct: 447 SAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMY 499
>AY280371-1|AAQ21367.1| 519|Homo sapiens cytochrome P450 4A22K
protein.
Length = 519
Score = 159 bits (385), Expect = 2e-38
Identities = 105/390 (26%), Positives = 192/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G L+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYKFLAPWIGYSLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ M L ++ +AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEFFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++ + L++ S N
Sbjct: 471 RALTLLRFELLPDPTRTPIPMARLVLKSKN 500
>D13705-1|BAA02864.1| 521|Homo sapiens fatty acid omega-hydroxylase
protein.
Length = 521
Score = 156 bits (379), Expect = 1e-37
Identities = 108/391 (27%), Positives = 191/391 (48%), Gaps = 12/391 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + + + R+A K+ E K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLSHQHTRPKVIQLRKAQLQKEGELEK--IKRKRHLDFLD 294
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 295 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 354
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 355 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 413
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 414 LSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVG 471
Query: 377 LVHL-LRRYKVTADISKIEFKLDALMVPSDN 406
L L R+++ D ++I + L++ S N
Sbjct: 472 QQALTLVRFELLPDPTRIPIPIARLVLKSKN 502
>AL135960-10|CAI19737.1| 519|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 519
Score = 156 bits (379), Expect = 1e-37
Identities = 104/390 (26%), Positives = 193/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + +G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ +AF + + D N Q Y+ A+ ++ +++ +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHG 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++I + L++ S N
Sbjct: 471 RALTLLRFELLPDPTRIPIPMARLVLKSKN 500
>AF208532-1|AAF76722.1| 519|Homo sapiens fatty acid
omega-hydroxylase CYP4A11 protein.
Length = 519
Score = 156 bits (379), Expect = 1e-37
Identities = 104/390 (26%), Positives = 193/390 (49%), Gaps = 12/390 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + +G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ +AF + + D N Q Y+ A+ ++ +++ +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHG 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTT 376
L IYGL+ +P P+ F P R+ G +AF FS G RNCIGK +A+ +K
Sbjct: 413 LSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVA 470
Query: 377 LVHLLRRYKVTADISKIEFKLDALMVPSDN 406
L R+++ D ++I + L++ S N
Sbjct: 471 RALTLLRFELLPDPTRIPIPIARLVLKSKN 500
>BC041158-1|AAH41158.1| 455|Homo sapiens CYP4A11 protein protein.
Length = 455
Score = 136 bits (330), Expect = 1e-31
Identities = 93/345 (26%), Positives = 169/345 (48%), Gaps = 12/345 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKR 361
L IYGL+ +P P+ F P R+ G +AF FS G R
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSR 455
>AL731892-4|CAH72779.1| 455|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 11 protein.
Length = 455
Score = 136 bits (330), Expect = 1e-31
Identities = 93/345 (26%), Positives = 169/345 (48%), Gaps = 12/345 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + W+G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ AF + + D N Q Y+ A+ ++ ++ R +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI S
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHS 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKR 361
L IYGL+ +P P+ F P R+ G +AF FS G R
Sbjct: 413 LSIYGLHHNPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSR 455
>AL135960-11|CAI19738.1| 455|Homo sapiens cytochrome P450, family
4, subfamily A, polypeptide 22 protein.
Length = 455
Score = 129 bits (312), Expect = 2e-29
Identities = 90/345 (26%), Positives = 168/345 (48%), Gaps = 12/345 (3%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQ 82
H Y+F + +G GL+ +G+TW +HR++L PAF +L Y + R ++ E
Sbjct: 117 HGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEEL 176
Query: 83 M-KSGPVLISAAFKEMALKALLSTAFGIEVE-ECDFN-QKYMHAVDEVMAVLTRRFQNIL 139
+ + P+ + M L ++ +AF + + D N Q Y+ A+ ++ +++ +N
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAF 236
Query: 140 LHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSD 199
N +Y L++ + + +++VI ++ L+ + E + K+ D
Sbjct: 237 HENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK---IKRKRHLDFLD 293
Query: 200 LLL--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS 257
+LL K + +DK++R EVDT +F G DT++ ++ ++ L ++P+ Q++ +EI
Sbjct: 294 ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHG 353
Query: 258 VCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCM 316
+ GD A + ++ YT +KE LRLYP P + R+ + ++P +
Sbjct: 354 LLGDG-ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 317 LGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKR 361
L IYGL+ +P P+ F P R+ G +AF FS G R
Sbjct: 413 LSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQHSHAFLPFSGGSR 455
>D12621-1|BAA02145.1| 389|Homo sapiens cytochrome P-450LTBV
protein.
Length = 389
Score = 126 bits (305), Expect = 1e-28
Identities = 80/267 (29%), Positives = 139/267 (52%), Gaps = 7/267 (2%)
Query: 25 FYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEIQM 83
FY F WLGDGL+ S+GE W RHR++L PAF +L Y +FN ES N++ A ++
Sbjct: 124 FYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFN-ESVNIMHAKWQLLA 182
Query: 84 KSGPVLIS--AAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLH 141
G + M L +L F + + +Y+ A+ E+ A++T+R Q ILL+
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLY 242
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
F+Y L+ ++ + ++ VI +RR L ++ ++ KT D+L
Sbjct: 243 IDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVL 302
Query: 202 L--KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
L K D + +D++IR E DT +F G DT++ ++ V+ L +PE Q++ QE++ +
Sbjct: 303 LLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362
Query: 260 GDSD-ADVDKLQHPRLVYTEAVLKETL 285
D + +++ +L + +KE+L
Sbjct: 363 KDREPKEIEWDDLAQLPFLTMCIKESL 389
>J04813-1|AAA02993.1| 502|Homo sapiens cytochrome P450 PCN3
protein.
Length = 502
Score = 123 bits (296), Expect = 1e-27
Identities = 102/422 (24%), Positives = 192/422 (45%), Gaps = 17/422 (4%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + + G PV + F ++ + T+FG+ ++ + Q
Sbjct: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200
Query: 119 K-YMHAVDEVM--AVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRR 175
++ + + + L F +I+L AL +TI +S V K+
Sbjct: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK-DTINFLSKSVNRMKKS 259
Query: 176 ALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMT 235
L +KQ+ + +Q+ + +A +D E+ + IF G +T+S +++
Sbjct: 260 RLNDKQKHRLDFLQLMIDSQNSKETE----SHKALSDLELAAQSIIFIFAGYETTSSVLS 315
Query: 236 VVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVL 295
+ L ++P++Q K+ +EI +V + A ++ Y + V+ ETLRL+P+ +
Sbjct: 316 FTLYELATHPDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLE 374
Query: 296 RKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAG 355
R + ++++ IP S ++ Y L+ P + + FRPER+ + DP +
Sbjct: 375 RTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD-SIDPYIYTP 433
Query: 356 FSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDNCYAKFE 412
F G RNCIG +AL++MK L+ +L+ + ++I KLD L+ P K +
Sbjct: 434 FGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVD 493
Query: 413 SR 414
SR
Sbjct: 494 SR 495
>BC033862-1|AAH33862.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 protein.
Length = 502
Score = 123 bits (296), Expect = 1e-27
Identities = 102/422 (24%), Positives = 192/422 (45%), Gaps = 17/422 (4%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + + G PV + F ++ + T+FG+ ++ + Q
Sbjct: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200
Query: 119 K-YMHAVDEVM--AVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRR 175
++ + + + L F +I+L AL +TI +S V K+
Sbjct: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK-DTINFLSKSVNRMKKS 259
Query: 176 ALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMT 235
L +KQ+ + +Q+ + +A +D E+ + IF G +T+S +++
Sbjct: 260 RLNDKQKHRLDFLQLMIDSQNSKETE----SHKALSDLELAAQSIIFIFAGYETTSSVLS 315
Query: 236 VVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVL 295
+ L ++P++Q K+ +EI +V + A ++ Y + V+ ETLRL+P+ +
Sbjct: 316 FTLYELATHPDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLE 374
Query: 296 RKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAG 355
R + ++++ IP S ++ Y L+ P + + FRPER+ + DP +
Sbjct: 375 RTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD-SIDPYIYTP 433
Query: 356 FSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDNCYAKFE 412
F G RNCIG +AL++MK L+ +L+ + ++I KLD L+ P K +
Sbjct: 434 FGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVD 493
Query: 413 SR 414
SR
Sbjct: 494 SR 495
>AC005020-1|AAS02016.1| 502|Homo sapiens unknown protein.
Length = 502
Score = 123 bits (296), Expect = 1e-27
Identities = 102/422 (24%), Positives = 192/422 (45%), Gaps = 17/422 (4%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + + G PV + F ++ + T+FG+ ++ + Q
Sbjct: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200
Query: 119 K-YMHAVDEVM--AVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRR 175
++ + + + L F +I+L AL +TI +S V K+
Sbjct: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK-DTINFLSKSVNRMKKS 259
Query: 176 ALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMT 235
L +KQ+ + +Q+ + +A +D E+ + IF G +T+S +++
Sbjct: 260 RLNDKQKHRLDFLQLMIDSQNSKETE----SHKALSDLELAAQSIIFIFAGYETTSSVLS 315
Query: 236 VVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVL 295
+ L ++P++Q K+ +EI +V + A ++ Y + V+ ETLRL+P+ +
Sbjct: 316 FTLYELATHPDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLE 374
Query: 296 RKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAG 355
R + ++++ IP S ++ Y L+ P + + FRPER+ + DP +
Sbjct: 375 RTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD-SIDPYIYTP 433
Query: 356 FSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDNCYAKFE 412
F G RNCIG +AL++MK L+ +L+ + ++I KLD L+ P K +
Sbjct: 434 FGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVD 493
Query: 413 SR 414
SR
Sbjct: 494 SR 495
>J04449-1|AAA35747.1| 502|Homo sapiens cytochrome P450 nifedipine
oxidase protein.
Length = 502
Score = 122 bits (295), Expect = 2e-27
Identities = 104/427 (24%), Positives = 194/427 (45%), Gaps = 27/427 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN-ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRAL 177
V+ +L F + L F + + L+ + I +V N R+++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSIIFPFLIPILE------VLNICVFPREVTNFLRKSV 252
Query: 178 KNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTSS 231
K +ES ++K L++ + + A +D E+ + IF G +T+S
Sbjct: 253 KRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 310
Query: 232 QIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYPI 290
+++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+PI
Sbjct: 311 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFPI 368
Query: 291 TPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDP 350
+ R + ++++ IP M+ Y L+R P + + F PER+ + DP
Sbjct: 369 AMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 428
Query: 351 NAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDNC 407
+ F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 YTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPV 488
Query: 408 YAKFESR 414
K ESR
Sbjct: 489 VLKVESR 495
>M13785-1|AAA35742.1| 504|Homo sapiens protein ( Human liver
glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
complete cds. ).
Length = 504
Score = 122 bits (293), Expect = 3e-27
Identities = 99/384 (25%), Positives = 179/384 (46%), Gaps = 22/384 (5%)
Query: 43 ETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKA 101
E WKR R LL+P F+ L + + L+ + + ++G PV + F ++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDV 183
Query: 102 LLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELI 159
+ S++FG+ V+ + Q + V+ +L F + L F + + L+ +
Sbjct: 184 ITSSSFGVNVDSLNNPQDPL--VENTKKLLRFDFLDPFFLSITVFPFLIPILE------V 235
Query: 160 ETITTMSNKVINSKRRALKNKQESHENGCASEKKT--QSMSDLLLKGLDDE---AFTDKE 214
I +V N R+A+K +ES + Q M D + E A +D E
Sbjct: 236 LNICVFPREVTNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSHKNSKETESHKALSDLE 295
Query: 215 IRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPR 273
+ + IF G +T+S +++ ++ L ++P++Q K+ +EI +V + + D + +
Sbjct: 296 LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--Q 353
Query: 274 LVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAH 333
+ Y + V+ ETLRL+PI + R + ++++ IP M+ Y L+R P + +
Sbjct: 354 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPE 413
Query: 334 TFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISK 392
F PER+ + DP + F G RNCIG +AL++MK L+ +L+ + ++
Sbjct: 414 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 473
Query: 393 IEFKLD--ALMVPSDNCYAKFESR 414
I KL L+ P K ESR
Sbjct: 474 IPLKLSLGGLLQPEKPVVLKVESR 497
>D00003-1|BAA00001.1| 504|Homo sapiens cytochrome P-450 protein.
Length = 504
Score = 122 bits (293), Expect = 3e-27
Identities = 99/384 (25%), Positives = 179/384 (46%), Gaps = 22/384 (5%)
Query: 43 ETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKA 101
E WKR R LL+P F+ L + + L+ + + ++G PV + F ++
Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDVFGAYSMDV 183
Query: 102 LLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELI 159
+ S++FG+ V+ + Q + V+ +L F + L F + + L+ +
Sbjct: 184 ITSSSFGVNVDSLNNPQDPL--VENTKKLLRFDFLDPFFLSITVFPFLIPILE------V 235
Query: 160 ETITTMSNKVINSKRRALKNKQESHENGCASEKKT--QSMSDLLLKGLDDE---AFTDKE 214
I +V N R+A+K +ES + Q M D + E A +D E
Sbjct: 236 LNICVFPREVTNFLRKAVKRMKESRLEDTQKHRVDFLQLMIDSHKNSKETESHKALSDLE 295
Query: 215 IRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPR 273
+ + IF G +T+S +++ ++ L ++P++Q K+ +EI +V + + D + +
Sbjct: 296 LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--Q 353
Query: 274 LVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAH 333
+ Y + V+ ETLRL+PI + R + ++++ IP M+ Y L+R P + +
Sbjct: 354 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPE 413
Query: 334 TFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISK 392
F PER+ + DP + F G RNCIG +AL++MK L+ +L+ + ++
Sbjct: 414 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 473
Query: 393 IEFKLD--ALMVPSDNCYAKFESR 414
I KL L+ P K ESR
Sbjct: 474 IPLKLSLGGLLQPEKPVVLKVESR 497
>AF182273-1|AAF13598.1| 503|Homo sapiens cytochrome P450-3A4
protein.
Length = 503
Score = 122 bits (293), Expect = 3e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGCETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>M18907-1|AAA35745.1| 503|Homo sapiens protein ( Human P450 mRNA
encoding nifedipine oxidase, complete cds. ).
Length = 503
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>M14096-1|AAA35744.1| 503|Homo sapiens protein ( Human cytochrome
P-450 nifedipine oxidase mRNA, complet cds. ).
Length = 503
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>DQ924960-1|ABI96208.1| 503|Homo sapiens cytochrome P450 family 3
subfamily A polypeptide 4 protein.
Length = 503
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>DQ005611-1|AAY16980.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>BC101631-1|AAI01632.1| 503|Homo sapiens cytochrome P450, subfamily
IIIA, polypeptide 4 protein.
Length = 503
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>BC069418-1|AAH69418.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 4 protein.
Length = 503
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>AK223008-1|BAD96728.1| 502|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 5 variant protein.
Length = 502
Score = 121 bits (292), Expect = 4e-27
Identities = 102/422 (24%), Positives = 191/422 (45%), Gaps = 17/422 (4%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRPLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + + G PV + F ++ + T+FG+ ++ + Q
Sbjct: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200
Query: 119 K-YMHAVDEVM--AVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRR 175
++ + + + L F +I+L AL +TI +S V K+
Sbjct: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK-DTINFLSKSVNRMKKS 259
Query: 176 ALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMT 235
L +KQ+ + +Q+ + +A +D E+ + IF G +T+S +++
Sbjct: 260 RLNDKQKHRLDFLQLMIDSQNSKETE----SHKALSDLELAAQSIIFIFAGYETTSSVLS 315
Query: 236 VVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVL 295
+ L ++P++Q K+ +EI +V + A ++ Y + V+ ETLRL+P+ +
Sbjct: 316 FTLYELATHPDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPVAIRLE 374
Query: 296 RKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAG 355
R ++++ IP S ++ Y L+ P + + FRPER+ + DP +
Sbjct: 375 RTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD-SIDPYIYTP 433
Query: 356 FSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDNCYAKFE 412
F G RNCIG +AL++MK L+ +L+ + ++I KLD L+ P K +
Sbjct: 434 FGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVD 493
Query: 413 SR 414
SR
Sbjct: 494 SR 495
>AJ563376-2|CAD91645.1| 430|Homo sapiens cytochrome P450 protein.
Length = 430
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 8 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 67
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 68 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 125
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 126 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 179
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 180 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 237
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 238 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 295
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 296 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 355
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 356 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 415
Query: 407 CYAKFESR 414
K ESR
Sbjct: 416 VVLKVESR 423
>AJ563375-1|CAD91343.1| 503|Homo sapiens cytochrome P450 protein.
Length = 503
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>AF280107-2|AAG32290.1| 503|Homo sapiens cytochrome P450
polypeptide 4 protein.
Length = 503
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>AF209389-1|AAF21034.1| 503|Homo sapiens cytochrome P450 IIIA4
protein.
Length = 503
Score = 121 bits (292), Expect = 4e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>X12387-1|CAA30944.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (cyp3 locus). ).
Length = 503
Score = 121 bits (291), Expect = 5e-27
Identities = 104/428 (24%), Positives = 194/428 (45%), Gaps = 28/428 (6%)
Query: 3 ITVITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQ 59
+ ITDP+ TV + F + +G + + E WKR R LL+P F+
Sbjct: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140
Query: 60 MLNIYTVVFNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQ 118
L + + L+ + + ++G PV + F ++ + ST+FG+ ++ N
Sbjct: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS--LNN 198
Query: 119 KYMHAVDEVMAVLTRRFQN--ILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRA 176
V+ +L F + L F + + L+ + I +V N R++
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE------VLNICVFPREVTNFLRKS 252
Query: 177 LKNKQESHENGCASEKKTQSMSDLLLKGLDDE------AFTDKEIRNEVDTLIFTGSDTS 230
+K +ES ++K L++ + + A +D E+ + IF G +T+
Sbjct: 253 VKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
Query: 231 SQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-SDADVDKLQHPRLVYTEAVLKETLRLYP 289
S +++ ++ L ++P++Q K+ +EI +V + + D + ++ Y + V+ ETLRL+P
Sbjct: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QMEYLDMVVNETLRLFP 368
Query: 290 ITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDD 349
I + R + ++++ IP M+ Y L+R P + + F PER+ + D
Sbjct: 369 IAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428
Query: 350 PNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLD--ALMVPSDN 406
P + F G RNCIG +AL++MK L+ +L+ + ++I KL L+ P
Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488
Query: 407 CYAKFESR 414
K ESR
Sbjct: 489 VVLKVESR 496
>D00408-1|BAA00310.1| 503|Homo sapiens cytochrome P-450 HFLa
protein.
Length = 503
Score = 118 bits (285), Expect = 3e-26
Identities = 91/362 (25%), Positives = 170/362 (46%), Gaps = 20/362 (5%)
Query: 32 WLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSG-PVLI 90
++ + + + E WKR R LL+P F+ L + + L+ + + ++G PV +
Sbjct: 113 FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSA 150
F ++ + ST+FG+ ++ N V+ +L RF + + FV +
Sbjct: 173 KHVFGAYSMDVITSTSFGVSIDS--LNNPQDPFVENTKKLL--RFNPL---DPFVLSIKV 225
Query: 151 LKKKEDELIE-TITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL---KGLD 206
L IT KVI+ +++K +E ++K L++ D
Sbjct: 226 FPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLK--ETQKHRVDFLQLMIDSQNSKD 283
Query: 207 DE---AFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-S 262
E A +D E+ + IF G +T+S +++ ++ L ++P++Q KV +EI +V + +
Sbjct: 284 SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA 343
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGL 322
D + +L Y + V+ ETLRL+P+ + R + ++++ IP M+ Y L
Sbjct: 344 PPTYDTVL--QLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
+ P + + F PER+ + DP + F G RNCIG +AL++MK LV +L+
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
Query: 383 RY 384
+
Sbjct: 462 NF 463
>BC067436-1|AAH67436.1| 503|Homo sapiens cytochrome P450, family 3,
subfamily A, polypeptide 7 protein.
Length = 503
Score = 118 bits (285), Expect = 3e-26
Identities = 91/362 (25%), Positives = 170/362 (46%), Gaps = 20/362 (5%)
Query: 32 WLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSG-PVLI 90
++ + + + E WKR R LL+P F+ L + + L+ + + ++G PV +
Sbjct: 113 FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSA 150
F ++ + ST+FG+ ++ N V+ +L RF + + FV +
Sbjct: 173 KHVFGAYSMDVITSTSFGVSIDS--LNNPQDPFVENTKKLL--RFNPL---DPFVLSIKV 225
Query: 151 LKKKEDELIE-TITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL---KGLD 206
L IT KVI+ +++K +E ++K L++ D
Sbjct: 226 FPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLK--ETQKHRVDFLQLMIDSQNSKD 283
Query: 207 DE---AFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-S 262
E A +D E+ + IF G +T+S +++ ++ L ++P++Q KV +EI +V + +
Sbjct: 284 SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA 343
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGL 322
D + +L Y + V+ ETLRL+P+ + R + ++++ IP M+ Y L
Sbjct: 344 PPTYDTVL--QLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
+ P + + F PER+ + DP + F G RNCIG +AL++MK LV +L+
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
Query: 383 RY 384
+
Sbjct: 462 NF 463
>AF315325-1|AAG48618.1| 535|Homo sapiens cytochrome P450 variant
3A7 protein.
Length = 535
Score = 118 bits (285), Expect = 3e-26
Identities = 91/362 (25%), Positives = 170/362 (46%), Gaps = 20/362 (5%)
Query: 32 WLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSG-PVLI 90
++ + + + E WKR R LL+P F+ L + + L+ + + ++G PV +
Sbjct: 113 FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSA 150
F ++ + ST+FG+ ++ N V+ +L RF + + FV +
Sbjct: 173 KHVFGAYSMDVITSTSFGVSIDS--LNNPQDPFVENTKKLL--RFNPL---DPFVLSIKV 225
Query: 151 LKKKEDELIE-TITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL---KGLD 206
L IT KVI+ +++K +E ++K L++ D
Sbjct: 226 FPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLK--ETQKHRVDFLQLMIDSQNSKD 283
Query: 207 DE---AFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-S 262
E A +D E+ + IF G +T+S +++ ++ L ++P++Q KV +EI +V + +
Sbjct: 284 SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA 343
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGL 322
D + +L Y + V+ ETLRL+P+ + R + ++++ IP M+ Y L
Sbjct: 344 PPTYDTVL--QLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
+ P + + F PER+ + DP + F G RNCIG +AL++MK LV +L+
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
Query: 383 RY 384
+
Sbjct: 462 NF 463
>AF280107-3|AAG32289.1| 503|Homo sapiens cytochrome P450
polypeptide 7 protein.
Length = 503
Score = 118 bits (285), Expect = 3e-26
Identities = 91/362 (25%), Positives = 170/362 (46%), Gaps = 20/362 (5%)
Query: 32 WLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSG-PVLI 90
++ + + + E WKR R LL+P F+ L + + L+ + + ++G PV +
Sbjct: 113 FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSA 150
F ++ + ST+FG+ ++ N V+ +L RF + + FV +
Sbjct: 173 KHVFGAYSMDVITSTSFGVSIDS--LNNPQDPFVENTKKLL--RFNPL---DPFVLSIKV 225
Query: 151 LKKKEDELIE-TITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL---KGLD 206
L IT KVI+ +++K +E ++K L++ D
Sbjct: 226 FPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLK--ETQKHRVDFLQLMIDSQNSKD 283
Query: 207 DE---AFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD-S 262
E A +D E+ + IF G +T+S +++ ++ L ++P++Q KV +EI +V + +
Sbjct: 284 SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA 343
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGL 322
D + +L Y + V+ ETLRL+P+ + R + ++++ IP M+ Y L
Sbjct: 344 PPTYDTVL--QLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVL 401
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
+ P + + F PER+ + DP + F G RNCIG +AL++MK LV +L+
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQ 461
Query: 383 RY 384
+
Sbjct: 462 NF 463
>BC022539-1|AAH22539.1| 500|Homo sapiens cytochrome P450, family
46, subfamily A, polypeptide 1 protein.
Length = 500
Score = 112 bits (269), Expect = 3e-24
Identities = 95/358 (26%), Positives = 151/358 (42%), Gaps = 18/358 (5%)
Query: 28 FASNWLGDGLVTSSG-ETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSG 86
F G GLV+ E W + R++++ AFS+ L FN ++ L+ +E +
Sbjct: 116 FGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQ 175
Query: 87 -PVLISAAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFV 145
PV + A+ L AFG+E QK + ++M +N L F+
Sbjct: 176 TPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA--KFL 233
Query: 146 YKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGL 205
++ E I + + + +R ALK +E + K + +
Sbjct: 234 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ------ 287
Query: 206 DDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDAD 265
DDE D + T G +TS+ + VM L PEI ++ E+ V G S
Sbjct: 288 DDEGLLDNFV-----TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRY 341
Query: 266 VDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRH 325
+D RL Y VLKE+LRLYP R E E + +P N+ + Y + R
Sbjct: 342 LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 401
Query: 326 PVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRR 383
+ D TF P+R+ G P + FS+G R+CIG+ +A + +K + LL+R
Sbjct: 402 DTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457
>AF094480-1|AAD41244.1| 500|Homo sapiens cholesterol 24-hydroxylase
protein.
Length = 500
Score = 112 bits (269), Expect = 3e-24
Identities = 95/358 (26%), Positives = 151/358 (42%), Gaps = 18/358 (5%)
Query: 28 FASNWLGDGLVTSSG-ETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSG 86
F G GLV+ E W + R++++ AFS+ L FN ++ L+ +E +
Sbjct: 116 FGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQ 175
Query: 87 -PVLISAAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFV 145
PV + A+ L AFG+E QK + ++M +N L F+
Sbjct: 176 TPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA--KFL 233
Query: 146 YKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGL 205
++ E I + + + +R ALK +E + K + +
Sbjct: 234 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ------ 287
Query: 206 DDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDAD 265
DDE D + T G +TS+ + VM L PEI ++ E+ V G S
Sbjct: 288 DDEGLLDNFV-----TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRY 341
Query: 266 VDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRH 325
+D RL Y VLKE+LRLYP R E E + +P N+ + Y + R
Sbjct: 342 LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 401
Query: 326 PVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRR 383
+ D TF P+R+ G P + FS+G R+CIG+ +A + +K + LL+R
Sbjct: 402 DTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457
>AY390424-1|AAQ92352.1| 503|Homo sapiens cytochrome P450 CYP3A43.3
protein.
Length = 503
Score = 111 bits (267), Expect = 4e-24
Identities = 96/405 (23%), Positives = 176/405 (43%), Gaps = 12/405 (2%)
Query: 5 VITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQML 61
VI DP+ TV + F Q +G L + E WKR R LL+PAF+
Sbjct: 83 VIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF 142
Query: 62 NIYTVVFNRESRNLISAIEIQMK-SGPVLISAAFKEMALKALLSTAFGIEVEECDFNQKY 120
+ ++ L+ ++ + + S + + F + + T FG+ ++ + Q
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 121 MHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITT--MSNKVINSKRRALK 178
+ + L +LL + F + + L T + N + K LK
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLK 262
Query: 179 NKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVV 238
+KQ+ + +Q+ + +A +D E+ + +IF DT+S + ++
Sbjct: 263 DKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318
Query: 239 MLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT 298
L ++P++Q K+ +EI +V + A V ++ Y + V+ ETLRL+P+ V R
Sbjct: 319 YELATHPDVQQKLQEEIDAVLANK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377
Query: 299 ENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSV 358
+ +I++ IP M+ IY L+ P + + F PER+ + D + F
Sbjct: 378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGA 437
Query: 359 GKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLDALMV 402
G RNCIG +AL ++K ++ L+ + ++I KLD L +
Sbjct: 438 GPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482
>AY390425-1|AAQ92353.1| 503|Homo sapiens cytochrome P450 CYP3A43.1
protein.
Length = 503
Score = 110 bits (265), Expect = 8e-24
Identities = 96/405 (23%), Positives = 176/405 (43%), Gaps = 12/405 (2%)
Query: 5 VITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQML 61
VI DP+ TV + F Q +G L + E WKR R LL+PAF+
Sbjct: 83 VIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF 142
Query: 62 NIYTVVFNRESRNLISAIEIQMK-SGPVLISAAFKEMALKALLSTAFGIEVEECDFNQKY 120
+ ++ L+ ++ + + S + + F + + T FG+ ++ + Q
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 121 MHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITT--MSNKVINSKRRALK 178
+ + L +LL + F + + L T + N + K LK
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLK 262
Query: 179 NKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVV 238
+KQ+ + +Q+ + +A +D E+ + +IF DT+S + ++
Sbjct: 263 DKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318
Query: 239 MLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT 298
L ++P++Q K+ +EI +V + A V ++ Y + V+ ETLRL+P+ V R
Sbjct: 319 YELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377
Query: 299 ENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSV 358
+ +I++ IP M+ IY L+ P + + F PER+ + D + F
Sbjct: 378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGA 437
Query: 359 GKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLDALMV 402
G RNCIG +AL ++K ++ L+ + ++I KLD L +
Sbjct: 438 GPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482
>AF337813-1|AAK38841.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 110 bits (265), Expect = 8e-24
Identities = 96/405 (23%), Positives = 176/405 (43%), Gaps = 12/405 (2%)
Query: 5 VITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQML 61
VI DP+ TV + F Q +G L + E WKR R LL+PAF+
Sbjct: 83 VIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF 142
Query: 62 NIYTVVFNRESRNLISAIEIQMK-SGPVLISAAFKEMALKALLSTAFGIEVEECDFNQKY 120
+ ++ L+ ++ + + S + + F + + T FG+ ++ + Q
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 121 MHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITT--MSNKVINSKRRALK 178
+ + L +LL + F + + L T + N + K LK
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLK 262
Query: 179 NKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVV 238
+KQ+ + +Q+ + +A +D E+ + +IF DT+S + ++
Sbjct: 263 DKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318
Query: 239 MLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT 298
L ++P++Q K+ +EI +V + A V ++ Y + V+ ETLRL+P+ V R
Sbjct: 319 YELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377
Query: 299 ENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSV 358
+ +I++ IP M+ IY L+ P + + F PER+ + D + F
Sbjct: 378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGA 437
Query: 359 GKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLDALMV 402
G RNCIG +AL ++K ++ L+ + ++I KLD L +
Sbjct: 438 GPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482
>AF319634-1|AAK00325.1| 503|Homo sapiens cytochrome P450 CYP3A43
protein.
Length = 503
Score = 110 bits (265), Expect = 8e-24
Identities = 96/405 (23%), Positives = 176/405 (43%), Gaps = 12/405 (2%)
Query: 5 VITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQML 61
VI DP+ TV + F Q +G L + E WKR R LL+PAF+
Sbjct: 83 VIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF 142
Query: 62 NIYTVVFNRESRNLISAIEIQMK-SGPVLISAAFKEMALKALLSTAFGIEVEECDFNQKY 120
+ ++ L+ ++ + + S + + F + + T FG+ ++ + Q
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 121 MHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITT--MSNKVINSKRRALK 178
+ + L +LL + F + + L T + N + K LK
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLK 262
Query: 179 NKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVV 238
+KQ+ + +Q+ + +A +D E+ + +IF DT+S + ++
Sbjct: 263 DKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318
Query: 239 MLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT 298
L ++P++Q K+ +EI +V + A V ++ Y + V+ ETLRL+P+ V R
Sbjct: 319 YELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377
Query: 299 ENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSV 358
+ +I++ IP M+ IY L+ P + + F PER+ + D + F
Sbjct: 378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGA 437
Query: 359 GKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLDALMV 402
G RNCIG +AL ++K ++ L+ + ++I KLD L +
Sbjct: 438 GPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482
>AF280108-1|AAG33009.1| 503|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 503
Score = 110 bits (265), Expect = 8e-24
Identities = 96/405 (23%), Positives = 176/405 (43%), Gaps = 12/405 (2%)
Query: 5 VITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQML 61
VI DP+ TV + F Q +G L + E WKR R LL+PAF+
Sbjct: 83 VIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF 142
Query: 62 NIYTVVFNRESRNLISAIEIQMK-SGPVLISAAFKEMALKALLSTAFGIEVEECDFNQKY 120
+ ++ L+ ++ + + S + + F + + T FG+ ++ + Q
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 121 MHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITT--MSNKVINSKRRALK 178
+ + L +LL + F + + L T + N + K LK
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLK 262
Query: 179 NKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVV 238
+KQ+ + +Q+ + +A +D E+ + +IF DT+S + ++
Sbjct: 263 DKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318
Query: 239 MLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT 298
L ++P++Q K+ +EI +V + A V ++ Y + V+ ETLRL+P+ V R
Sbjct: 319 YELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377
Query: 299 ENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSV 358
+ +I++ IP M+ IY L+ P + + F PER+ + D + F
Sbjct: 378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGA 437
Query: 359 GKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLDALMV 402
G RNCIG +AL ++K ++ L+ + ++I KLD L +
Sbjct: 438 GPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482
>AC011904-4|AAS07395.1| 503|Homo sapiens unknown protein.
Length = 503
Score = 110 bits (265), Expect = 8e-24
Identities = 96/405 (23%), Positives = 176/405 (43%), Gaps = 12/405 (2%)
Query: 5 VITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQML 61
VI DP+ TV + F Q +G L + E WKR R LL+PAF+
Sbjct: 83 VIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF 142
Query: 62 NIYTVVFNRESRNLISAIEIQMK-SGPVLISAAFKEMALKALLSTAFGIEVEECDFNQKY 120
+ ++ L+ ++ + + S + + F + + T FG+ ++ + Q
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 121 MHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITT--MSNKVINSKRRALK 178
+ + L +LL + F + + L T + N + K LK
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLK 262
Query: 179 NKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVV 238
+KQ+ + +Q+ + +A +D E+ + +IF DT+S + ++
Sbjct: 263 DKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318
Query: 239 MLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT 298
L ++P++Q K+ +EI +V + A V ++ Y + V+ ETLRL+P+ V R
Sbjct: 319 YELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377
Query: 299 ENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSV 358
+ +I++ IP M+ IY L+ P + + F PER+ + D + F
Sbjct: 378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGA 437
Query: 359 GKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLDALMV 402
G RNCIG +AL ++K ++ L+ + ++I KLD L +
Sbjct: 438 GPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482
>AY288916-1|AAP31972.1| 508|Homo sapiens cytochrome P450, family
27, subfamily B, polypeptide 1 protein.
Length = 508
Score = 107 bits (257), Expect = 7e-23
Identities = 104/396 (26%), Positives = 173/396 (43%), Gaps = 29/396 (7%)
Query: 36 GLVTSSGETWKRHRKLLNPAFSQ-QMLNIYTVVFNRESRNLISAIEIQMKSG---PVLI- 90
GL+T+ GE W+R R LL P + Q Y N +L+ + Q G P L+
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
Query: 91 --SAAFKEMALKALLSTAFG-----IEVEECDFNQKYMHAVDEVMA--VLTRRFQNILLH 141
+ F + L+ + + G +E + + ++ AV V +LT + L H
Sbjct: 185 DVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH 244
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
L + D++ + + + +R A + + NG EK +S + L
Sbjct: 245 -LVPGPWGRLCRDWDQMF----AFAQRHVE-RREA----EAAMRNGGQPEKDLESGAHLT 294
Query: 202 LKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
L E + I V L+ G DT S ++ + L +PE+Q ++ EI +
Sbjct: 295 -HFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSP 353
Query: 262 -SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIY 320
S A +L +AV+KE LRLYP+ P R + +I + Y IP N+ L Y
Sbjct: 354 GSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 321 GLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
+R P P+ ++FRP RWL G P P A F GKR+C+G+ A + ++ L +
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQI 472
Query: 381 LRRYKVTAD--ISKIEFKLDALMVPSDNCYAKFESR 414
L ++V + + + K ++VP + +F R
Sbjct: 473 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508
>AF256213-1|AAG00416.1| 508|Homo sapiens 25- hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 107 bits (257), Expect = 7e-23
Identities = 104/396 (26%), Positives = 173/396 (43%), Gaps = 29/396 (7%)
Query: 36 GLVTSSGETWKRHRKLLNPAFSQ-QMLNIYTVVFNRESRNLISAIEIQMKSG---PVLI- 90
GL+T+ GE W+R R LL P + Q Y N +L+ + Q G P L+
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
Query: 91 --SAAFKEMALKALLSTAFG-----IEVEECDFNQKYMHAVDEVMA--VLTRRFQNILLH 141
+ F + L+ + + G +E + + ++ AV V +LT + L H
Sbjct: 185 DVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH 244
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
L + D++ + + + +R A + + NG EK +S + L
Sbjct: 245 -LVPGPWGRLCRDWDQMF----AFAQRHVE-RREA----EAAMRNGGQPEKDLESGAHLT 294
Query: 202 LKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
L E + I V L+ G DT S ++ + L +PE+Q ++ EI +
Sbjct: 295 -HFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSP 353
Query: 262 -SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIY 320
S A +L +AV+KE LRLYP+ P R + +I + Y IP N+ L Y
Sbjct: 354 GSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 321 GLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
+R P P+ ++FRP RWL G P P A F GKR+C+G+ A + ++ L +
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQI 472
Query: 381 LRRYKVTAD--ISKIEFKLDALMVPSDNCYAKFESR 414
L ++V + + + K ++VP + +F R
Sbjct: 473 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508
>AF246895-1|AAF64299.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 107 bits (257), Expect = 7e-23
Identities = 104/396 (26%), Positives = 173/396 (43%), Gaps = 29/396 (7%)
Query: 36 GLVTSSGETWKRHRKLLNPAFSQ-QMLNIYTVVFNRESRNLISAIEIQMKSG---PVLI- 90
GL+T+ GE W+R R LL P + Q Y N +L+ + Q G P L+
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
Query: 91 --SAAFKEMALKALLSTAFG-----IEVEECDFNQKYMHAVDEVMA--VLTRRFQNILLH 141
+ F + L+ + + G +E + + ++ AV V +LT + L H
Sbjct: 185 DVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH 244
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
L + D++ + + + +R A + + NG EK +S + L
Sbjct: 245 -LVPGPWGRLCRDWDQMF----AFAQRHVE-RREA----EAAMRNGGQPEKDLESGAHLT 294
Query: 202 LKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
L E + I V L+ G DT S ++ + L +PE+Q ++ EI +
Sbjct: 295 -HFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSP 353
Query: 262 -SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIY 320
S A +L +AV+KE LRLYP+ P R + +I + Y IP N+ L Y
Sbjct: 354 GSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 321 GLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
+R P P+ ++FRP RWL G P P A F GKR+C+G+ A + ++ L +
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQI 472
Query: 381 LRRYKVTAD--ISKIEFKLDALMVPSDNCYAKFESR 414
L ++V + + + K ++VP + +F R
Sbjct: 473 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508
>AF027152-1|AAC51854.1| 508|Homo sapiens P450 25-hydroxyvitamin D-1
alpha hydroxylase protein.
Length = 508
Score = 107 bits (257), Expect = 7e-23
Identities = 104/396 (26%), Positives = 173/396 (43%), Gaps = 29/396 (7%)
Query: 36 GLVTSSGETWKRHRKLLNPAFSQ-QMLNIYTVVFNRESRNLISAIEIQMKSG---PVLI- 90
GL+T+ GE W+R R LL P + Q Y N +L+ + Q G P L+
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
Query: 91 --SAAFKEMALKALLSTAFG-----IEVEECDFNQKYMHAVDEVMA--VLTRRFQNILLH 141
+ F + L+ + + G +E + + ++ AV V +LT + L H
Sbjct: 185 DVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH 244
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
L + D++ + + + +R A + + NG EK +S + L
Sbjct: 245 -LVPGPWGRLCRDWDQMF----AFAQRHVE-RREA----EAAMRNGGQPEKDLESGAHLT 294
Query: 202 LKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
L E + I V L+ G DT S ++ + L +PE+Q ++ EI +
Sbjct: 295 -HFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSP 353
Query: 262 -SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIY 320
S A +L +AV+KE LRLYP+ P R + +I + Y IP N+ L Y
Sbjct: 354 GSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 321 GLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
+R P P+ ++FRP RWL G P P A F GKR+C+G+ A + ++ L +
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQI 472
Query: 381 LRRYKVTAD--ISKIEFKLDALMVPSDNCYAKFESR 414
L ++V + + + K ++VP + +F R
Sbjct: 473 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508
>AF020192-1|AAC51853.1| 508|Homo sapiens 25-hydroxyvitamin
D-1-alpha-hydroxylase protein.
Length = 508
Score = 107 bits (257), Expect = 7e-23
Identities = 104/396 (26%), Positives = 173/396 (43%), Gaps = 29/396 (7%)
Query: 36 GLVTSSGETWKRHRKLLNPAFSQ-QMLNIYTVVFNRESRNLISAIEIQMKSG---PVLI- 90
GL+T+ GE W+R R LL P + Q Y N +L+ + Q G P L+
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
Query: 91 --SAAFKEMALKALLSTAFG-----IEVEECDFNQKYMHAVDEVMA--VLTRRFQNILLH 141
+ F + L+ + + G +E + + ++ AV V +LT + L H
Sbjct: 185 DVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH 244
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
L + D++ + + + +R A + + NG EK +S + L
Sbjct: 245 -LVPGPWGRLCRDWDQMF----AFAQRHVE-RREA----EAAMRNGGQPEKDLESGAHLT 294
Query: 202 LKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
L E + I V L+ G DT S ++ + L +PE+Q ++ EI +
Sbjct: 295 -HFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSP 353
Query: 262 -SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIY 320
S A +L +AV+KE LRLYP+ P R + +I + Y IP N+ L Y
Sbjct: 354 GSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 321 GLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
+R P P+ ++FRP RWL G P P A F GKR+C+G+ A + ++ L +
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQI 472
Query: 381 LRRYKVTAD--ISKIEFKLDALMVPSDNCYAKFESR 414
L ++V + + + K ++VP + +F R
Sbjct: 473 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508
>AB006987-1|BAA23418.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 107 bits (257), Expect = 7e-23
Identities = 104/396 (26%), Positives = 173/396 (43%), Gaps = 29/396 (7%)
Query: 36 GLVTSSGETWKRHRKLLNPAFSQ-QMLNIYTVVFNRESRNLISAIEIQMKSG---PVLI- 90
GL+T+ GE W+R R LL P + Q Y N +L+ + Q G P L+
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
Query: 91 --SAAFKEMALKALLSTAFG-----IEVEECDFNQKYMHAVDEVMA--VLTRRFQNILLH 141
+ F + L+ + + G +E + + ++ AV V +LT + L H
Sbjct: 185 DVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH 244
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
L + D++ + + + +R A + + NG EK +S + L
Sbjct: 245 -LVPGPWGRLCRDWDQMF----AFAQRHVE-RREA----EAAMRNGGQPEKDLESGAHLT 294
Query: 202 LKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
L E + I V L+ G DT S ++ + L +PE+Q ++ EI +
Sbjct: 295 -HFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSP 353
Query: 262 -SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIY 320
S A +L +AV+KE LRLYP+ P R + +I + Y IP N+ L Y
Sbjct: 354 GSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 321 GLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
+R P P+ ++FRP RWL G P P A F GKR+C+G+ A + ++ L +
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQI 472
Query: 381 LRRYKVTAD--ISKIEFKLDALMVPSDNCYAKFESR 414
L ++V + + + K ++VP + +F R
Sbjct: 473 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508
>AB005990-1|BAA22657.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 107 bits (257), Expect = 7e-23
Identities = 104/396 (26%), Positives = 173/396 (43%), Gaps = 29/396 (7%)
Query: 36 GLVTSSGETWKRHRKLLNPAFSQ-QMLNIYTVVFNRESRNLISAIEIQMKSG---PVLI- 90
GL+T+ GE W+R R LL P + Q Y N +L+ + Q G P L+
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
Query: 91 --SAAFKEMALKALLSTAFG-----IEVEECDFNQKYMHAVDEVMA--VLTRRFQNILLH 141
+ F + L+ + + G +E + + ++ AV V +LT + L H
Sbjct: 185 DVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH 244
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
L + D++ + + + +R A + + NG EK +S + L
Sbjct: 245 -LVPGPWGRLCRDWDQMF----AFAQRHVE-RREA----EAAMRNGGQPEKDLESGAHLT 294
Query: 202 LKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
L E + I V L+ G DT S ++ + L +PE+Q ++ EI +
Sbjct: 295 -HFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSP 353
Query: 262 -SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIY 320
S A +L +AV+KE LRLYP+ P R + +I + Y IP N+ L Y
Sbjct: 354 GSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 321 GLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
+R P P+ ++FRP RWL G P P A F GKR+C+G+ A + ++ L +
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQI 472
Query: 381 LRRYKVTAD--ISKIEFKLDALMVPSDNCYAKFESR 414
L ++V + + + K ++VP + +F R
Sbjct: 473 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508
>AB005989-1|BAA22656.1| 508|Homo sapiens 25-hydroxyvitamin D3
1alpha-hydroxylase protein.
Length = 508
Score = 107 bits (257), Expect = 7e-23
Identities = 104/396 (26%), Positives = 173/396 (43%), Gaps = 29/396 (7%)
Query: 36 GLVTSSGETWKRHRKLLNPAFSQ-QMLNIYTVVFNRESRNLISAIEIQMKSG---PVLI- 90
GL+T+ GE W+R R LL P + Q Y N +L+ + Q G P L+
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
Query: 91 --SAAFKEMALKALLSTAFG-----IEVEECDFNQKYMHAVDEVMA--VLTRRFQNILLH 141
+ F + L+ + + G +E + + ++ AV V +LT + L H
Sbjct: 185 DVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH 244
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
L + D++ + + + +R A + + NG EK +S + L
Sbjct: 245 -LVPGPWGRLCRDWDQMF----AFAQRHVE-RREA----EAAMRNGGQPEKDLESGAHLT 294
Query: 202 LKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
L E + I V L+ G DT S ++ + L +PE+Q ++ EI +
Sbjct: 295 -HFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSP 353
Query: 262 -SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIY 320
S A +L +AV+KE LRLYP+ P R + +I + Y IP N+ L Y
Sbjct: 354 GSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 321 GLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
+R P P+ ++FRP RWL G P P A F GKR+C+G+ A + ++ L +
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQI 472
Query: 381 LRRYKVTAD--ISKIEFKLDALMVPSDNCYAKFESR 414
L ++V + + + K ++VP + +F R
Sbjct: 473 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508
>AB005038-1|BAA23416.1| 508|Homo sapiens 25-hydroxyvitamin D3
1-alpha-hydroxylase protein.
Length = 508
Score = 107 bits (257), Expect = 7e-23
Identities = 104/396 (26%), Positives = 173/396 (43%), Gaps = 29/396 (7%)
Query: 36 GLVTSSGETWKRHRKLLNPAFSQ-QMLNIYTVVFNRESRNLISAIEIQMKSG---PVLI- 90
GL+T+ GE W+R R LL P + Q Y N +L+ + Q G P L+
Sbjct: 125 GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVR 184
Query: 91 --SAAFKEMALKALLSTAFG-----IEVEECDFNQKYMHAVDEVMA--VLTRRFQNILLH 141
+ F + L+ + + G +E + + ++ AV V +LT + L H
Sbjct: 185 DVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH 244
Query: 142 NSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLL 201
L + D++ + + + +R A + + NG EK +S + L
Sbjct: 245 -LVPGPWGRLCRDWDQMF----AFAQRHVE-RREA----EAAMRNGGQPEKDLESGAHLT 294
Query: 202 LKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD 261
L E + I V L+ G DT S ++ + L +PE+Q ++ EI +
Sbjct: 295 -HFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSP 353
Query: 262 -SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIY 320
S A +L +AV+KE LRLYP+ P R + +I + Y IP N+ L Y
Sbjct: 354 GSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 321 GLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
+R P P+ ++FRP RWL G P P A F GKR+C+G+ A + ++ L +
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQI 472
Query: 381 LRRYKVTAD--ISKIEFKLDALMVPSDNCYAKFESR 414
L ++V + + + K ++VP + +F R
Sbjct: 473 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508
>AK131190-1|BAD18388.1| 372|Homo sapiens .-.-). protein.
Length = 372
Score = 106 bits (255), Expect = 1e-22
Identities = 65/211 (30%), Positives = 104/211 (49%), Gaps = 4/211 (1%)
Query: 208 EAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVD 267
+A T +EI V ++ G DT+S ++ V LL +PE+Q VY+EI G+
Sbjct: 163 QALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPT- 221
Query: 268 KLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPV 327
P++ A+LKETLRL+P+ P R T+ ++ + Y IP + L Y +
Sbjct: 222 AADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDE 281
Query: 328 WGPDAHTFRPERWLELGGVPDDPN-AFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY-- 384
P A FRPERWL G + N F G R+CIG+ A + + ++ LL+ +
Sbjct: 282 NFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEI 341
Query: 385 KVTADISKIEFKLDALMVPSDNCYAKFESRK 415
K ++ + + K L+ P + +F +RK
Sbjct: 342 KTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK 372
>AF280109-1|AAG33010.1| 504|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 504
Score = 106 bits (254), Expect = 2e-22
Identities = 96/406 (23%), Positives = 176/406 (43%), Gaps = 13/406 (3%)
Query: 5 VITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQML 61
VI DP+ TV + F Q +G L + E WKR R LL+PAF+
Sbjct: 83 VIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF 142
Query: 62 NIYTVVFNRESRNLISAIEIQMK-SGPVLISAAFKEMALKALLSTAFGIEVEECDFNQKY 120
+ ++ L+ ++ + + S + + F + + T FG+ ++ + Q
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 121 MHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITT--MSNKVINSKRRALK 178
+ + L +LL + F + + L T + N + K LK
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLK 262
Query: 179 NKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVV 238
+KQ+ + +Q+ + +A +D E+ + +IF DT+S + ++
Sbjct: 263 DKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318
Query: 239 MLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT 298
L ++P++Q K+ +EI +V + A V ++ Y + V+ ETLRL+P+ V R
Sbjct: 319 YELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377
Query: 299 ENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPE-RWLELGGVPDDPNAFAGFS 357
+ +I++ IP M+ IY L+ P + + F PE R+ + D + F
Sbjct: 378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFG 437
Query: 358 VGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLDALMV 402
G RNCIG +AL ++K ++ L+ + ++I KLD L +
Sbjct: 438 AGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 483
>AC011904-5|AAS07394.1| 504|Homo sapiens unknown protein.
Length = 504
Score = 106 bits (254), Expect = 2e-22
Identities = 96/406 (23%), Positives = 176/406 (43%), Gaps = 13/406 (3%)
Query: 5 VITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQML 61
VI DP+ TV + F Q +G L + E WKR R LL+PAF+
Sbjct: 83 VIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF 142
Query: 62 NIYTVVFNRESRNLISAIEIQMK-SGPVLISAAFKEMALKALLSTAFGIEVEECDFNQKY 120
+ ++ L+ ++ + + S + + F + + T FG+ ++ + Q
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 121 MHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITT--MSNKVINSKRRALK 178
+ + L +LL + F + + L T + N + K LK
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLK 262
Query: 179 NKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVV 238
+KQ+ + +Q+ + +A +D E+ + +IF DT+S + ++
Sbjct: 263 DKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318
Query: 239 MLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT 298
L ++P++Q K+ +EI +V + A V ++ Y + V+ ETLRL+P+ V R
Sbjct: 319 YELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377
Query: 299 ENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPE-RWLELGGVPDDPNAFAGFS 357
+ +I++ IP M+ IY L+ P + + F PE R+ + D + F
Sbjct: 378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFG 437
Query: 358 VGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLDALMV 402
G RNCIG +AL ++K ++ L+ + ++I KLD L +
Sbjct: 438 AGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 483
>BC039307-1|AAH39307.1| 372|Homo sapiens FLJ16008 protein protein.
Length = 372
Score = 105 bits (253), Expect = 2e-22
Identities = 64/211 (30%), Positives = 104/211 (49%), Gaps = 4/211 (1%)
Query: 208 EAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVD 267
+A T +EI V ++ G DT+S ++ V +L +PE+Q VY+EI G+
Sbjct: 163 QALTLQEIYANVTEMLLAGVDTTSFTLSWTVYILARHPEVQQTVYREIVKNLGERHVPT- 221
Query: 268 KLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPV 327
P++ A+LKETLRL+P+ P R T+ ++ + Y IP + L Y +
Sbjct: 222 AADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDE 281
Query: 328 WGPDAHTFRPERWLELGGVPDDPN-AFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY-- 384
P A FRPERWL G + N F G R+CIG+ A + + ++ LL+ +
Sbjct: 282 NFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEI 341
Query: 385 KVTADISKIEFKLDALMVPSDNCYAKFESRK 415
K ++ + + K L+ P + +F +RK
Sbjct: 342 KTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK 372
>AJ563377-1|CAD91345.1| 353|Homo sapiens cytochrome P450 protein.
Length = 353
Score = 103 bits (246), Expect = 2e-21
Identities = 84/339 (24%), Positives = 158/339 (46%), Gaps = 24/339 (7%)
Query: 88 VLISAAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQN--ILLHNSFV 145
VL+ F ++ + ST+FG+ ++ N V+ +L F + L F
Sbjct: 20 VLLYIVFGAYSMDVITSTSFGVNIDS--LNNPQDPFVENTKKLLRFDFLDPFFLSITVFP 77
Query: 146 YKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGL 205
+ + L+ + I +V N R+++K +ES ++K L++
Sbjct: 78 FLIPILE------VLNICVFPREVTNFLRKSVKRMKESRLED--TQKHRVDFLQLMIDSQ 129
Query: 206 DDE------AFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
+ + A +D E+ + IF G +T+S +++ ++ L ++P++Q K+ +EI +V
Sbjct: 130 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 189
Query: 260 GD-SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLG 318
+ + D + ++ Y + V+ ETLRL+PI + R + ++++ IP M+
Sbjct: 190 PNKAPPTYDTVL--QMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIP 247
Query: 319 IYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
Y L+R P + + F PER+ + DP + F G RNCIG +AL++MK L+
Sbjct: 248 SYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALI 307
Query: 379 HLLRRYKV-TADISKIEFKLD--ALMVPSDNCYAKFESR 414
+L+ + ++I KL L+ P K ESR
Sbjct: 308 RVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 346
>AK097373-1|BAC05026.1| 340|Homo sapiens protein ( Homo sapiens
cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to
CYTOCHROME P450 4A1 (EC 1.14.15.3). ).
Length = 340
Score = 100 bits (240), Expect = 8e-21
Identities = 58/230 (25%), Positives = 117/230 (50%), Gaps = 9/230 (3%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
++ +W+G GLVT G WK+HR+++ P F+ +L I+ + ++ R +++ E +
Sbjct: 114 HKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSKSVRMMLNKWEEHIAQ 173
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIE--VEECDFNQKYMHAVDEVMAVLTRRFQNILLHN 142
L + M L +++ AF + ++ Y+ AV + + +R N L HN
Sbjct: 174 NSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHN 233
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
V+K S+ + + + + + KVI ++ +LK+K + ++K+ Q D+LL
Sbjct: 234 DLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQD----TTQKRRQDFLDILL 289
Query: 203 --KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDK 250
K + + F++ +++ EV T +F G DT++ ++ + L YPE Q +
Sbjct: 290 SAKSENTKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQR 339
>BC100981-1|AAI00982.1| 393|Homo sapiens CYP3A43 protein protein.
Length = 393
Score = 95.5 bits (227), Expect = 3e-19
Identities = 63/239 (26%), Positives = 115/239 (48%), Gaps = 6/239 (2%)
Query: 165 MSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIF 224
+ N + K LK+KQ+ + +Q+ + +A +D E+ + +IF
Sbjct: 139 LKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIF 194
Query: 225 TGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKET 284
DT+S + ++ L ++P++Q K+ +EI +V + A V ++ Y + V+ ET
Sbjct: 195 AAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNET 253
Query: 285 LRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELG 344
LRL+P+ V R + +I++ IP M+ IY L+ P + + F PER+ +
Sbjct: 254 LRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKN 313
Query: 345 GVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADISKIEFKLDALMV 402
D + F G RNCIG +AL ++K ++ L+ + ++I KLD L +
Sbjct: 314 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 372
>X59812-1|CAA42481.1| 530|Homo sapiens Vitamin D3 25-hydroxylase
protein.
Length = 530
Score = 95.1 bits (226), Expect = 4e-19
Identities = 62/209 (29%), Positives = 99/209 (47%), Gaps = 7/209 (3%)
Query: 213 KEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHP 272
+E + L+ G DT+S +T + L PEIQ+ +++E+ V K
Sbjct: 322 REAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHK-DFA 380
Query: 273 RLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDA 332
+ +AVLKETLRLYP+ P R E EI++ + P N+ + Y ++R P +
Sbjct: 381 HMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEP 440
Query: 333 HTFRPERWLELG--GVPDDPNAFAG--FSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
+F+P RWL P + F F G R C+G+ A + M+ L L+++YKV
Sbjct: 441 ESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVL 500
Query: 389 DISKIEFKLDA--LMVPSDNCYAKFESRK 415
E K A ++VP+ +F R+
Sbjct: 501 APETGELKSVARIVLVPNKKVGLQFLQRQ 529
>M62401-1|AAA52142.1| 531|Homo sapiens sterol 27-hydroxylase
protein.
Length = 531
Score = 95.1 bits (226), Expect = 4e-19
Identities = 62/209 (29%), Positives = 99/209 (47%), Gaps = 7/209 (3%)
Query: 213 KEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHP 272
+E + L+ G DT+S +T + L PEIQ+ +++E+ V K
Sbjct: 323 REAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHK-DFA 381
Query: 273 RLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDA 332
+ +AVLKETLRLYP+ P R E EI++ + P N+ + Y ++R P +
Sbjct: 382 HMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEP 441
Query: 333 HTFRPERWLELG--GVPDDPNAFAG--FSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
+F+P RWL P + F F G R C+G+ A + M+ L L+++YKV
Sbjct: 442 ESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVL 501
Query: 389 DISKIEFKLDA--LMVPSDNCYAKFESRK 415
E K A ++VP+ +F R+
Sbjct: 502 APETGELKSVARIVLVPNKKVGLQFLQRQ 530
>BC051851-1|AAH51851.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 95.1 bits (226), Expect = 4e-19
Identities = 62/209 (29%), Positives = 99/209 (47%), Gaps = 7/209 (3%)
Query: 213 KEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHP 272
+E + L+ G DT+S +T + L PEIQ+ +++E+ V K
Sbjct: 323 REAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHK-DFA 381
Query: 273 RLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDA 332
+ +AVLKETLRLYP+ P R E EI++ + P N+ + Y ++R P +
Sbjct: 382 HMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEP 441
Query: 333 HTFRPERWLELG--GVPDDPNAFAG--FSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
+F+P RWL P + F F G R C+G+ A + M+ L L+++YKV
Sbjct: 442 ESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVL 501
Query: 389 DISKIEFKLDA--LMVPSDNCYAKFESRK 415
E K A ++VP+ +F R+
Sbjct: 502 APETGELKSVARIVLVPNKKVGLQFLQRQ 530
>BC040430-1|AAH40430.1| 531|Homo sapiens cytochrome P450, family
27, subfamily A, polypeptide 1 protein.
Length = 531
Score = 95.1 bits (226), Expect = 4e-19
Identities = 62/209 (29%), Positives = 99/209 (47%), Gaps = 7/209 (3%)
Query: 213 KEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHP 272
+E + L+ G DT+S +T + L PEIQ+ +++E+ V K
Sbjct: 323 REAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHK-DFA 381
Query: 273 RLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDA 332
+ +AVLKETLRLYP+ P R E EI++ + P N+ + Y ++R P +
Sbjct: 382 HMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEP 441
Query: 333 HTFRPERWLELG--GVPDDPNAFAG--FSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
+F+P RWL P + F F G R C+G+ A + M+ L L+++YKV
Sbjct: 442 ESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVL 501
Query: 389 DISKIEFKLDA--LMVPSDNCYAKFESRK 415
E K A ++VP+ +F R+
Sbjct: 502 APETGELKSVARIVLVPNKKVGLQFLQRQ 530
>AY178622-1|AAO21126.1| 531|Homo sapiens steroid hydroxylase
protein.
Length = 531
Score = 94.3 bits (224), Expect = 7e-19
Identities = 62/209 (29%), Positives = 98/209 (46%), Gaps = 7/209 (3%)
Query: 213 KEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHP 272
+E + L+ G DT+S +T + L PEIQ +++E+ V K
Sbjct: 323 REAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQKALHEEVVGVVPAGQVPQHK-DFA 381
Query: 273 RLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDA 332
+ +AVLKETLRLYP+ P R E EI++ + P N+ + Y ++R P +
Sbjct: 382 HMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYEVSRDPTAFSEP 441
Query: 333 HTFRPERWLELG--GVPDDPNAFAG--FSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
+F+P RWL P + F F G R C+G+ A + M+ L L+++YKV
Sbjct: 442 ESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVL 501
Query: 389 DISKIEFKLDA--LMVPSDNCYAKFESRK 415
E K A ++VP+ +F R+
Sbjct: 502 APETGELKSVARIVLVPNKKVGLQFLQRQ 530
>BC104909-1|AAI04910.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 91.1 bits (216), Expect = 7e-18
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 6/178 (3%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADV--D 267
F+ + + V LI G++T++ ++ ++ + YP IQ +V +EI + G + D
Sbjct: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354
Query: 268 KLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHP 326
K + P YTEAVL E LR I P+ + T + ++ Y+IP + + +Y ++
Sbjct: 355 KCKMP---YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411
Query: 327 VWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY 384
+ D F PER+L+ G A FS+G+R+C+G+ A + M LL+R+
Sbjct: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469
>BC104907-1|AAI04908.1| 501|Homo sapiens cytochrome P450, family 2,
subfamily R, polypeptide 1 protein.
Length = 501
Score = 91.1 bits (216), Expect = 7e-18
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 6/178 (3%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADV--D 267
F+ + + V LI G++T++ ++ ++ + YP IQ +V +EI + G + D
Sbjct: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354
Query: 268 KLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHP 326
K + P YTEAVL E LR I P+ + T + ++ Y+IP + + +Y ++
Sbjct: 355 KCKMP---YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411
Query: 327 VWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY 384
+ D F PER+L+ G A FS+G+R+C+G+ A + M LL+R+
Sbjct: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469
>AY323817-1|AAQ23114.1| 501|Homo sapiens cytochrome P450 2R1
protein.
Length = 501
Score = 91.1 bits (216), Expect = 7e-18
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 6/178 (3%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADV--D 267
F+ + + V LI G++T++ ++ ++ + YP IQ +V +EI + G + D
Sbjct: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354
Query: 268 KLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHP 326
K + P YTEAVL E LR I P+ + T + ++ Y+IP + + +Y ++
Sbjct: 355 KCKMP---YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411
Query: 327 VWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY 384
+ D F PER+L+ G A FS+G+R+C+G+ A + M LL+R+
Sbjct: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469
>BC035959-1|AAH35959.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 90.6 bits (215), Expect = 9e-18
Identities = 81/351 (23%), Positives = 156/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 193 RVMLDTSNTLFLRISLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 244
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KRR + +++ E C ++L+L + T + +
Sbjct: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 296
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 354
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 413
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 414 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>Y07508-1|CAA68807.1| 503|Homo sapiens protein ( Human mRNA for
aromatase P-450. ).
Length = 503
Score = 90.2 bits (214), Expect = 1e-17
Identities = 81/351 (23%), Positives = 156/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 244
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KRR + +++ E C ++L+L + T + +
Sbjct: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 296
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 354
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 413
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 414 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>X13589-1|CAA31929.1| 503|Homo sapiens protein ( Human mRNA for
aromatase (estrogen synthetase). ).
Length = 503
Score = 90.2 bits (214), Expect = 1e-17
Identities = 81/351 (23%), Positives = 156/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 244
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KRR + +++ E C ++L+L + T + +
Sbjct: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 296
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 354
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 413
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 414 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M30804-1|AAA35728.1| 503|Homo sapiens protein ( Human aromatase
cytochrome P-450 gene, exon 10. ).
Length = 503
Score = 90.2 bits (214), Expect = 1e-17
Identities = 81/351 (23%), Positives = 156/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 244
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KRR + +++ E C ++L+L + T + +
Sbjct: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 296
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 354
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 413
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 414 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M22246-1|AAA35557.1| 503|Homo sapiens protein ( Human aromatase
mRNA, complete cds. ).
Length = 503
Score = 90.2 bits (214), Expect = 1e-17
Identities = 81/351 (23%), Positives = 156/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 244
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KRR + +++ E C ++L+L + T + +
Sbjct: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 296
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 354
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 413
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 414 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>M18856-1|AAA35556.1| 419|Homo sapiens protein ( Human aromatase
(Aro1) mRNA, complete cds. ).
Length = 419
Score = 90.2 bits (214), Expect = 1e-17
Identities = 81/351 (23%), Positives = 156/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 49 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 108
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 109 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 160
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KRR + +++ E C ++L+L + T + +
Sbjct: 161 EKSVKDLKDAIEVLIAEKRRRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 212
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 213 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 270
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 271 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 329
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 330 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 376
>DQ118405-1|AAZ23558.1| 503|Homo sapiens cytochrome P450 subfamily
19 subfamily A polypeptide 1 protein.
Length = 503
Score = 90.2 bits (214), Expect = 1e-17
Identities = 81/351 (23%), Positives = 156/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 244
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KRR + +++ E C ++L+L + T + +
Sbjct: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 296
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 354
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 413
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 414 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>AY957953-1|AAX44046.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 90.2 bits (214), Expect = 1e-17
Identities = 81/351 (23%), Positives = 156/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 244
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KRR + +++ E C ++L+L + T + +
Sbjct: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 296
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 354
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 413
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 414 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>BC107785-1|AAI07786.1| 503|Homo sapiens cytochrome P450, family
19, subfamily A, polypeptide 1 protein.
Length = 503
Score = 89.4 bits (212), Expect = 2e-17
Identities = 81/351 (23%), Positives = 155/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L I ++E K D +Q +L+ +K+S L KK
Sbjct: 193 RVMLDTSNMLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 244
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KRR + +++ E C ++L+L + T + +
Sbjct: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 296
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 354
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 413
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 414 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>S67623-1|AAB29308.1| 257|Homo sapiens 25-hydroxyvitamin D
24-hydroxylase cytochrome P450 subunit protein.
Length = 257
Score = 88.6 bits (210), Expect = 4e-17
Identities = 65/217 (29%), Positives = 102/217 (47%), Gaps = 6/217 (2%)
Query: 191 EKKTQSMS-DLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQD 249
EK +Q S D L + KE+ V L +T++ + ++ L P++Q
Sbjct: 34 EKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQ 93
Query: 250 KVYQEIKSVCGDSDADVDKLQHPR-LVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYT 308
K+ +EI+SV ++ V + + R + Y +A LKE++RL P P R + L Y
Sbjct: 94 KLLKEIQSVLPENQ--VPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYA 151
Query: 309 IPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTY 368
+P + ML L D+ FRPERWL+ +P A F VGKR CIG+
Sbjct: 152 LPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ-EKEKINPFAHLPFGVGKRMCIGRRL 210
Query: 369 ALISMKTTLVHLLRRYKVTA-DISKIEFKLDALMVPS 404
A + + L ++R+Y + A D +E +VPS
Sbjct: 211 AELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPS 247
>AY858838-1|AAW50795.1| 372|Homo sapiens vitamin D 24-hydroxylase
splice variant protein.
Length = 372
Score = 88.6 bits (210), Expect = 4e-17
Identities = 65/217 (29%), Positives = 102/217 (47%), Gaps = 6/217 (2%)
Query: 191 EKKTQSMS-DLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQD 249
EK +Q S D L + KE+ V L +T++ + ++ L P++Q
Sbjct: 149 EKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQ 208
Query: 250 KVYQEIKSVCGDSDADVDKLQHPR-LVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYT 308
K+ +EI+SV ++ V + + R + Y +A LKE++RL P P R + L Y
Sbjct: 209 KLLKEIQSVLPENQ--VPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYA 266
Query: 309 IPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTY 368
+P + ML L D+ FRPERWL+ +P A F VGKR CIG+
Sbjct: 267 LPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ-EKEKINPFAHLPFGVGKRMCIGRRL 325
Query: 369 ALISMKTTLVHLLRRYKVTA-DISKIEFKLDALMVPS 404
A + + L ++R+Y + A D +E +VPS
Sbjct: 326 AELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPS 362
>AL138805-3|CAB91829.1| 514|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 514
Score = 88.6 bits (210), Expect = 4e-17
Identities = 65/217 (29%), Positives = 102/217 (47%), Gaps = 6/217 (2%)
Query: 191 EKKTQSMS-DLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQD 249
EK +Q S D L + KE+ V L +T++ + ++ L P++Q
Sbjct: 291 EKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQ 350
Query: 250 KVYQEIKSVCGDSDADVDKLQHPR-LVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYT 308
K+ +EI+SV ++ V + + R + Y +A LKE++RL P P R + L Y
Sbjct: 351 KLLKEIQSVLPENQ--VPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYA 408
Query: 309 IPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTY 368
+P + ML L D+ FRPERWL+ +P A F VGKR CIG+
Sbjct: 409 LPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ-EKEKINPFAHLPFGVGKRMCIGRRL 467
Query: 369 ALISMKTTLVHLLRRYKVTA-DISKIEFKLDALMVPS 404
A + + L ++R+Y + A D +E +VPS
Sbjct: 468 AELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPS 504
>AL138805-1|CAM27342.1| 372|Homo sapiens cytochrome P450, family
24, subfamily A, polypeptide 1 protein.
Length = 372
Score = 88.6 bits (210), Expect = 4e-17
Identities = 65/217 (29%), Positives = 102/217 (47%), Gaps = 6/217 (2%)
Query: 191 EKKTQSMS-DLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQD 249
EK +Q S D L + KE+ V L +T++ + ++ L P++Q
Sbjct: 149 EKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQ 208
Query: 250 KVYQEIKSVCGDSDADVDKLQHPR-LVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYT 308
K+ +EI+SV ++ V + + R + Y +A LKE++RL P P R + L Y
Sbjct: 209 KLLKEIQSVLPENQ--VPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYA 266
Query: 309 IPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTY 368
+P + ML L D+ FRPERWL+ +P A F VGKR CIG+
Sbjct: 267 LPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ-EKEKINPFAHLPFGVGKRMCIGRRL 325
Query: 369 ALISMKTTLVHLLRRYKVTA-DISKIEFKLDALMVPS 404
A + + L ++R+Y + A D +E +VPS
Sbjct: 326 AELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPS 362
>L13286-1|AAA62379.1| 513|Homo sapiens 1,25-dihydroxyvitamin D3
24-hydroxylase protein.
Length = 513
Score = 87.4 bits (207), Expect = 8e-17
Identities = 63/216 (29%), Positives = 100/216 (46%), Gaps = 4/216 (1%)
Query: 191 EKKTQSMS-DLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQD 249
EK +Q S D L + KE+ V L +T++ + ++ L P++Q
Sbjct: 290 EKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQ 349
Query: 250 KVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTI 309
K+ +EI+SV ++ ++ + Y +A LKE++RL P P R + L Y +
Sbjct: 350 KLLKEIQSVLPENQRPREE-DLRNMPYLKACLKESMRLTPGVPFTTRTLDKATVLGEYAL 408
Query: 310 PANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYA 369
P + ML L D+ FRPERWL+ +P A F VGKR CIG+ A
Sbjct: 409 PKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ-EKEKINPFAHLPFGVGKRMCIGRRLA 467
Query: 370 LISMKTTLVHLLRRYKVTA-DISKIEFKLDALMVPS 404
+ + L ++R+Y + A D +E +VPS
Sbjct: 468 ELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPS 503
>M28420-1|AAA52141.1| 419|Homo sapiens cytochrome P-450 aromatase
protein.
Length = 419
Score = 87.0 bits (206), Expect = 1e-16
Identities = 80/351 (22%), Positives = 155/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 49 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 108
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 109 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 160
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KR + +++ E C ++L+L + T + +
Sbjct: 161 EKSVKDLKDAIEVLIAEKRCRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 212
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 213 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 270
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 271 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 329
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 330 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 376
>J04127-1|AAA52132.1| 503|Homo sapiens CYP19 protein.
Length = 503
Score = 87.0 bits (206), Expect = 1e-16
Identities = 80/351 (22%), Positives = 155/351 (44%), Gaps = 24/351 (6%)
Query: 37 LVTSSGETWKRHRKLLNPAFSQQ-MLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFK 95
+ ++ E WK R A S ++ + TV +L E+ +SG V + +
Sbjct: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192
Query: 96 EMALKALLSTAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKE 155
+ L + I ++E K D +Q +L+ +K+S L KK
Sbjct: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDA--------WQALLIKPDIFFKISWLYKKY 244
Query: 156 DELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEI 215
++ ++ + +I KR + +++ E C ++L+L + T + +
Sbjct: 245 EKSVKDLKDAIEVLIAEKRCRISTEEKLEE--CMD-----FATELILAEKRGD-LTRENV 296
Query: 216 RNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLV 275
+ ++ DT S + ++ L+ +P +++ + +EI++V G+ D +D +Q +L
Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ--KLK 354
Query: 276 YTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTF 335
E + E++R P+ +V+RK + + Y + +N +L I ++R + P + F
Sbjct: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEF 413
Query: 336 RPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
E + + VP F F G R C GK A++ MK LV LLRR+ V
Sbjct: 414 TLENFAK--NVPY--RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460
>U37143-1|AAC50370.2| 502|Homo sapiens cytochrome P450
monooxygenase CYP2J2 protein.
Length = 502
Score = 86.6 bits (205), Expect = 1e-16
Identities = 87/356 (24%), Positives = 147/356 (41%), Gaps = 16/356 (4%)
Query: 35 DGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVV--FNRESRNLISAIEIQMKSGPVLISA 92
+GL+ SSG+ WK R+ A L ++ E+++L AI+ + P
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIK-EENGQPFDPHF 182
Query: 93 AFKEMALKALLSTAFGIEVEECD-FNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSAL 151
+ S FG E D + Q+ + +DEV + + L+N F + + L
Sbjct: 183 KINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASK--TCQLYNVFPWIMKFL 240
Query: 152 KKKEDELIETITTMSNKVIN--SKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
L + V + K R N E+ + A K+ + G +
Sbjct: 241 PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHT-----GNPTSS 295
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F ++ + L F G++T+S + ++ + YPEIQ+KV EI V G
Sbjct: 296 FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQ-QPSTA 354
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
+ YT AV+ E R+ I P+ V R+ + L Y +P + + + L+R P
Sbjct: 355 ARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTE 414
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY 384
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 415 WATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>BC032594-1|AAH32594.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 86.6 bits (205), Expect = 1e-16
Identities = 87/356 (24%), Positives = 147/356 (41%), Gaps = 16/356 (4%)
Query: 35 DGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVV--FNRESRNLISAIEIQMKSGPVLISA 92
+GL+ SSG+ WK R+ A L ++ E+++L AI+ + P
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIK-EENGQPFDPHF 182
Query: 93 AFKEMALKALLSTAFGIEVEECD-FNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSAL 151
+ S FG E D + Q+ + +DEV + + L+N F + + L
Sbjct: 183 KINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASK--TCQLYNVFPWIMKFL 240
Query: 152 KKKEDELIETITTMSNKVIN--SKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
L + V + K R N E+ + A K+ + G +
Sbjct: 241 PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHT-----GNPTSS 295
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F ++ + L F G++T+S + ++ + YPEIQ+KV EI V G
Sbjct: 296 FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQ-QPSTA 354
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
+ YT AV+ E R+ I P+ V R+ + L Y +P + + + L+R P
Sbjct: 355 ARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTE 414
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY 384
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 415 WATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>AY426985-1|AAQ93356.1| 502|Homo sapiens cytochrome P450, family 2,
subfamily J, polypeptide 2 protein.
Length = 502
Score = 86.6 bits (205), Expect = 1e-16
Identities = 87/356 (24%), Positives = 147/356 (41%), Gaps = 16/356 (4%)
Query: 35 DGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVV--FNRESRNLISAIEIQMKSGPVLISA 92
+GL+ SSG+ WK R+ A L ++ E+++L AI+ + P
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIK-EENGQPFDPHF 182
Query: 93 AFKEMALKALLSTAFGIEVEECD-FNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSAL 151
+ S FG E D + Q+ + +DEV + + L+N F + + L
Sbjct: 183 KINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASK--TCQLYNVFPWIMKFL 240
Query: 152 KKKEDELIETITTMSNKVIN--SKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
L + V + K R N E+ + A K+ + G +
Sbjct: 241 PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHT-----GNPTSS 295
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F ++ + L F G++T+S + ++ + YPEIQ+KV EI V G
Sbjct: 296 FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQ-QPSTA 354
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
+ YT AV+ E R+ I P+ V R+ + L Y +P + + + L+R P
Sbjct: 355 ARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTE 414
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY 384
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 415 WATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>AF272142-1|AAM44456.1| 502|Homo sapiens cytochrome P450 protein.
Length = 502
Score = 86.6 bits (205), Expect = 1e-16
Identities = 87/356 (24%), Positives = 147/356 (41%), Gaps = 16/356 (4%)
Query: 35 DGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVV--FNRESRNLISAIEIQMKSGPVLISA 92
+GL+ SSG+ WK R+ A L ++ E+++L AI+ + P
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIK-EENGQPFDPHF 182
Query: 93 AFKEMALKALLSTAFGIEVEECD-FNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSAL 151
+ S FG E D + Q+ + +DEV + + L+N F + + L
Sbjct: 183 KINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASK--TCQLYNVFPWIMKFL 240
Query: 152 KKKEDELIETITTMSNKVIN--SKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
L + V + K R N E+ + A K+ + G +
Sbjct: 241 PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHT-----GNPTSS 295
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F ++ + L F G++T+S + ++ + YPEIQ+KV EI V G
Sbjct: 296 FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQ-QPSTA 354
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
+ YT AV+ E R+ I P+ V R+ + L Y +P + + + L+R P
Sbjct: 355 ARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTE 414
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY 384
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 415 WATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>AF280110-1|AAG33011.1| 420|Homo sapiens cytochrome P450 subfamily
IIIA polypeptide 43 protein.
Length = 420
Score = 86.2 bits (204), Expect = 2e-16
Identities = 79/341 (23%), Positives = 146/341 (42%), Gaps = 11/341 (3%)
Query: 5 VITDPEDNLTVANGALHKHFFYQFASNWLG---DGLVTSSGETWKRHRKLLNPAFSQQML 61
VI DP+ TV + F Q +G L + E WKR R LL+PAF+
Sbjct: 83 VIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKF 142
Query: 62 NIYTVVFNRESRNLISAIEIQMK-SGPVLISAAFKEMALKALLSTAFGIEVEECDFNQKY 120
+ ++ L+ ++ + + S + + F + + T FG+ ++ + Q
Sbjct: 143 KEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDP 202
Query: 121 MHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITT--MSNKVINSKRRALK 178
+ + L +LL + F + + L T + N + K LK
Sbjct: 203 FLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLK 262
Query: 179 NKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVV 238
+KQ+ + +Q+ + +A +D E+ + +IF DT+S + ++
Sbjct: 263 DKQKHRVDFFQQMIDSQNSKETK----SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318
Query: 239 MLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT 298
L ++P++Q K+ +EI +V + A V ++ Y + V+ ETLRL+P+ V R
Sbjct: 319 YELATHPDVQQKLQEEIDAVLPNK-APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377
Query: 299 ENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPER 339
+ +I++ IP M+ IY L+ P + + F PER
Sbjct: 378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
>AB080265-1|BAB85489.1| 502|Homo sapiens cytochrome P450 2J2
protein.
Length = 502
Score = 86.2 bits (204), Expect = 2e-16
Identities = 87/356 (24%), Positives = 147/356 (41%), Gaps = 16/356 (4%)
Query: 35 DGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVV--FNRESRNLISAIEIQMKSGPVLISA 92
+GL+ SSG+ WK R+ A L ++ E+++L AI+ + P
Sbjct: 124 NGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIK-EENGQPFDPHF 182
Query: 93 AFKEMALKALLSTAFGIEVEECD-FNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSAL 151
+ S FG E D + Q+ + +DEV + + L+N F + + L
Sbjct: 183 KINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASK--TCQLYNVFPWIMKFL 240
Query: 152 KKKEDELIETITTMSNKVIN--SKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
L + V + K R N E+ + A K+ + G +
Sbjct: 241 PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHT-----GNPTSS 295
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F ++ + L F G++T+S + ++ + YPEIQ+KV EI V G
Sbjct: 296 FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQ-QPSTA 354
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
+ YT AV+ E R+ I P+ V R+ + L Y +P + + + L+R P
Sbjct: 355 ARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTE 414
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY 384
TF P+ +LE G AF FS+GKR C+G+ A + L++++
Sbjct: 415 WATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKF 469
>X05367-1|CAA28965.1| 521|Homo sapiens desmolase protein.
Length = 521
Score = 83.4 bits (197), Expect = 1e-15
Identities = 54/206 (26%), Positives = 101/206 (49%), Gaps = 5/206 (2%)
Query: 200 LLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
+L + L D + ++I+ V ++ G DT+S + + + ++QD + E+ +
Sbjct: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360
Query: 260 GDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGI 319
+ D+ + + +A +KETLRL+PI+ + R N++ L+ Y IPA + + I
Sbjct: 361 HQAQGDMATMLQ-LVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAI 419
Query: 320 YGLNRHPVWGPDAHTFRPERWLELG-GVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
Y L R P + D F P RWL + N GF G R C+G+ A + M L+
Sbjct: 420 YALGREPTFFFDPENFDPTRWLSKDKNITYFRN--LGFGWGVRQCLGRRIAELEMTIFLI 477
Query: 379 HLLRRYKVTAD-ISKIEFKLDALMVP 403
++L ++V +S + + +++P
Sbjct: 478 NMLENFRVEIQHLSDVGTTFNLILMP 503
>M28253-1|AAA36404.1| 239|Homo sapiens cytochrome P-450-scc
protein.
Length = 239
Score = 83.4 bits (197), Expect = 1e-15
Identities = 54/206 (26%), Positives = 101/206 (49%), Gaps = 5/206 (2%)
Query: 200 LLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
+L + L D + ++I+ V ++ G DT+S + + + ++QD + E+ +
Sbjct: 19 MLYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 78
Query: 260 GDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGI 319
+ D+ + + +A +KETLRL+PI+ + R N++ L+ Y IPA + + I
Sbjct: 79 HQAQGDMATMLQ-LVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAI 137
Query: 320 YGLNRHPVWGPDAHTFRPERWLELG-GVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
Y L R P + D F P RWL + N GF G R C+G+ A + M L+
Sbjct: 138 YALGREPTFFFDPENFDPTRWLSKDKNITYFRN--LGFGWGVRQCLGRRIAELEMTIFLI 195
Query: 379 HLLRRYKVTAD-ISKIEFKLDALMVP 403
++L ++V +S + + +++P
Sbjct: 196 NMLENFRVEIQHLSDVGTTFNLILMP 221
>M14565-1|AAA52162.1| 521|Homo sapiens CYP11A protein.
Length = 521
Score = 83.4 bits (197), Expect = 1e-15
Identities = 54/206 (26%), Positives = 101/206 (49%), Gaps = 5/206 (2%)
Query: 200 LLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
+L + L D + ++I+ V ++ G DT+S + + + ++QD + E+ +
Sbjct: 301 MLYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360
Query: 260 GDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGI 319
+ D+ + + +A +KETLRL+PI+ + R N++ L+ Y IPA + + I
Sbjct: 361 HQAQGDMATMLQ-LVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAI 419
Query: 320 YGLNRHPVWGPDAHTFRPERWLELG-GVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
Y L R P + D F P RWL + N GF G R C+G+ A + M L+
Sbjct: 420 YALGREPTFFFDPENFDPTRWLSKDKNITYFRN--LGFGWGVRQCLGRRIAELEMTIFLI 477
Query: 379 HLLRRYKVTAD-ISKIEFKLDALMVP 403
++L ++V +S + + +++P
Sbjct: 478 NMLENFRVEIQHLSDVGTTFNLILMP 503
>BC032329-1|AAH32329.1| 521|Homo sapiens cytochrome P450, family
11, subfamily A, polypeptide 1 protein.
Length = 521
Score = 83.4 bits (197), Expect = 1e-15
Identities = 54/206 (26%), Positives = 101/206 (49%), Gaps = 5/206 (2%)
Query: 200 LLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVC 259
+L + L D + ++I+ V ++ G DT+S + + + ++QD + E+ +
Sbjct: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360
Query: 260 GDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGI 319
+ D+ + + +A +KETLRL+PI+ + R N++ L+ Y IPA + + I
Sbjct: 361 HQAQGDMATMLQ-LVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAI 419
Query: 320 YGLNRHPVWGPDAHTFRPERWLELG-GVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLV 378
Y L R P + D F P RWL + N GF G R C+G+ A + M L+
Sbjct: 420 YALGREPTFFFDPENFDPTRWLSKDKNITYFRN--LGFGWGVRQCLGRRIAELEMTIFLI 477
Query: 379 HLLRRYKVTAD-ISKIEFKLDALMVP 403
++L ++V +S + + +++P
Sbjct: 478 NMLENFRVEIQHLSDVGTTFNLILMP 503
>BC132767-1|AAI32768.1| 544|Homo sapiens cytochrome P450, family 2,
subfamily U, polypeptide 1 protein.
Length = 544
Score = 82.6 bits (195), Expect = 2e-15
Identities = 50/185 (27%), Positives = 91/185 (49%), Gaps = 6/185 (3%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
K + +F ++ + + L G+DT++ + ++ + P++Q+KV++EI+ V G +
Sbjct: 330 KNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGAN 389
Query: 263 DAD--VDKLQHPRLVYTEAVLKETLRLYPITPVVL-RKTENEIKLKSYTIPANSNCMLGI 319
A DK Q P YTEA + E RL + P+ + T L+ YTIP + + +
Sbjct: 390 RAPSLTDKAQMP---YTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNL 446
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
+ ++R P F P R+L+ G F F +GKR C+G+ A + + V
Sbjct: 447 WSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVS 506
Query: 380 LLRRY 384
L++ +
Sbjct: 507 LMQSF 511
>AY343323-1|AAQ21380.1| 544|Homo sapiens cytochrome P450 protein.
Length = 544
Score = 82.6 bits (195), Expect = 2e-15
Identities = 50/185 (27%), Positives = 91/185 (49%), Gaps = 6/185 (3%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
K + +F ++ + + L G+DT++ + ++ + P++Q+KV++EI+ V G +
Sbjct: 330 KNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGAN 389
Query: 263 DAD--VDKLQHPRLVYTEAVLKETLRLYPITPVVL-RKTENEIKLKSYTIPANSNCMLGI 319
A DK Q P YTEA + E RL + P+ + T L+ YTIP + + +
Sbjct: 390 RAPSLTDKAQMP---YTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNL 446
Query: 320 YGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVH 379
+ ++R P F P R+L+ G F F +GKR C+G+ A + + V
Sbjct: 447 WSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVS 506
Query: 380 LLRRY 384
L++ +
Sbjct: 507 LMQSF 511
>BC032322-1|AAH32322.1| 509|Homo sapiens cytochrome P450, family
51, subfamily A, polypeptide 1 protein.
Length = 509
Score = 79.4 bits (187), Expect = 2e-14
Identities = 56/212 (26%), Positives = 95/212 (44%), Gaps = 7/212 (3%)
Query: 175 RALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIM 234
+A++ +++S E + Q++ D K D TD E+ + L+ G TSS
Sbjct: 272 KAIQKRRQSQEK---IDDILQTLLDATYK--DGRPLTDDEVAGMLIGLLLAGQHTSSTTS 326
Query: 235 TVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVV 294
+ L +Q K Y E K+VCG++ + Q L + +KETLRL P ++
Sbjct: 327 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPVMIM 386
Query: 295 LRKTENEIKLKSYTI-PANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAF 353
+R + YTI P + C+ W + F P+R+L+ + A+
Sbjct: 387 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSW-VERLDFNPDRYLQDNPASGEKFAY 445
Query: 354 AGFSVGKRNCIGKTYALISMKTTLVHLLRRYK 385
F G+ CIG+ +A + +KT +LR Y+
Sbjct: 446 VPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 477
>AL358613-3|CAH72804.1| 428|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 428
Score = 79.4 bits (187), Expect = 2e-14
Identities = 95/392 (24%), Positives = 166/392 (42%), Gaps = 34/392 (8%)
Query: 33 LGDGLVTSSGET-WKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGP--VL 89
LG G +++ ++ K+ +K++ AFS++ L Y V E + S++E + G +L
Sbjct: 51 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEE---VGSSLEQWLSCGERGLL 107
Query: 90 ISAAFKEMALKALLSTAFGIEVE---ECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVY 146
+ K + + + G E + + D Q+ + A +E +TR ++ + F
Sbjct: 108 VYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEE----MTRNLFSLPIDVPFSG 163
Query: 147 KLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLD 206
+K + I + I +K L+ + GC ++ L+ +
Sbjct: 164 LYRGMKARN-----LIHARIEQNIRAKICGLRASEAGQ--GCKD-----ALQLLIEHSWE 211
Query: 207 DEAFTDKEIRNEVDT-LIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS---VC-GD 261
D + + T L+F G +T++ T ++ LG YP + KV +E+KS +C +
Sbjct: 212 RGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSN 271
Query: 262 SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYG 321
D +D +L Y V+KETLRL P P R +L Y IP N + I
Sbjct: 272 QDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICD 331
Query: 322 LNRHPVWGPDAHTFRPERWLELGGVPDDPN--AFAGFSVGKRNCIGKTYALISMKTTLVH 379
+ + F P+R++ P+D + +F F G R+C+GK +A I +K V
Sbjct: 332 THDVAEIFTNKEEFNPDRFML--PHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVE 389
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDNCYAKF 411
L R K + P DN A+F
Sbjct: 390 LARHCDWQLLNGPPTMKTSPTVYPVDNLPARF 421
>AL358613-2|CAH72803.1| 497|Homo sapiens cytochrome P450, family
26, subfamily A, polypeptide 1 protein.
Length = 497
Score = 79.4 bits (187), Expect = 2e-14
Identities = 95/392 (24%), Positives = 166/392 (42%), Gaps = 34/392 (8%)
Query: 33 LGDGLVTSSGET-WKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGP--VL 89
LG G +++ ++ K+ +K++ AFS++ L Y V E + S++E + G +L
Sbjct: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEE---VGSSLEQWLSCGERGLL 176
Query: 90 ISAAFKEMALKALLSTAFGIEVE---ECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVY 146
+ K + + + G E + + D Q+ + A +E +TR ++ + F
Sbjct: 177 VYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEE----MTRNLFSLPIDVPFSG 232
Query: 147 KLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLD 206
+K + I + I +K L+ + GC ++ L+ +
Sbjct: 233 LYRGMKARN-----LIHARIEQNIRAKICGLRASEAGQ--GCKD-----ALQLLIEHSWE 280
Query: 207 DEAFTDKEIRNEVDT-LIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS---VC-GD 261
D + + T L+F G +T++ T ++ LG YP + KV +E+KS +C +
Sbjct: 281 RGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSN 340
Query: 262 SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYG 321
D +D +L Y V+KETLRL P P R +L Y IP N + I
Sbjct: 341 QDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICD 400
Query: 322 LNRHPVWGPDAHTFRPERWLELGGVPDDPN--AFAGFSVGKRNCIGKTYALISMKTTLVH 379
+ + F P+R++ P+D + +F F G R+C+GK +A I +K V
Sbjct: 401 THDVAEIFTNKEEFNPDRFML--PHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVE 458
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDNCYAKF 411
L R K + P DN A+F
Sbjct: 459 LARHCDWQLLNGPPTMKTSPTVYPVDNLPARF 490
>AF233625-1|AAF99279.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 79.4 bits (187), Expect = 2e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>AF005418-1|AAB88881.1| 497|Homo sapiens retinoic acid hydroxylase
protein.
Length = 497
Score = 79.4 bits (187), Expect = 2e-14
Identities = 95/392 (24%), Positives = 166/392 (42%), Gaps = 34/392 (8%)
Query: 33 LGDGLVTSSGET-WKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGP--VL 89
LG G +++ ++ K+ +K++ AFS++ L Y V E + S++E + G +L
Sbjct: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEE---VGSSLEQWLSCGERGLL 176
Query: 90 ISAAFKEMALKALLSTAFGIEVE---ECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVY 146
+ K + + + G E + + D Q+ + A +E +TR ++ + F
Sbjct: 177 VYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEE----MTRNLFSLPIDVPFSG 232
Query: 147 KLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLD 206
+K + I + I +K L+ + GC ++ L+ +
Sbjct: 233 LYRGMKARN-----LIHARIEQNIRAKICGLRASEAGQ--GCKD-----ALQLLIEHSWE 280
Query: 207 DEAFTDKEIRNEVDT-LIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKS---VC-GD 261
D + + T L+F G +T++ T ++ LG YP + KV +E+KS +C +
Sbjct: 281 RGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSN 340
Query: 262 SDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYG 321
D +D +L Y V+KETLRL P P R +L Y IP N + I
Sbjct: 341 QDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICD 400
Query: 322 LNRHPVWGPDAHTFRPERWLELGGVPDDPN--AFAGFSVGKRNCIGKTYALISMKTTLVH 379
+ + F P+R++ P+D + +F F G R+C+GK +A I +K V
Sbjct: 401 THDVAEIFTNKEEFNPDRFML--PHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVE 458
Query: 380 LLRRYKVTADISKIEFKLDALMVPSDNCYAKF 411
L R K + P DN A+F
Sbjct: 459 LARHCDWQLLNGPPTMKTSPTVYPVDNLPARF 490
>U23942-1|AAB39951.1| 509|Homo sapiens lanosterol 14-demethylase
cytochrome P450 protein.
Length = 509
Score = 79.0 bits (186), Expect = 3e-14
Identities = 56/212 (26%), Positives = 95/212 (44%), Gaps = 7/212 (3%)
Query: 175 RALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIM 234
+A++ +++S E + Q++ D K D TD E+ + L+ G TSS
Sbjct: 272 KAIQKRRQSQEK---IDDILQTLLDATYK--DGRPLTDDEVAGMLIGLLLAGQHTSSTTS 326
Query: 235 TVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVV 294
+ L +Q K Y E K+VCG++ + Q L + +KETLRL P ++
Sbjct: 327 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM 386
Query: 295 LRKTENEIKLKSYTI-PANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAF 353
+R + YTI P + C+ W + F P+R+L+ + A+
Sbjct: 387 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSW-VERLDFNPDRYLQDNPASGEKFAY 445
Query: 354 AGFSVGKRNCIGKTYALISMKTTLVHLLRRYK 385
F G+ CIG+ +A + +KT +LR Y+
Sbjct: 446 VPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 477
>D55653-1|BAA09512.1| 509|Homo sapiens lanosterol 14-demethylase
protein.
Length = 509
Score = 79.0 bits (186), Expect = 3e-14
Identities = 56/212 (26%), Positives = 95/212 (44%), Gaps = 7/212 (3%)
Query: 175 RALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIM 234
+A++ +++S E + Q++ D K D TD E+ + L+ G TSS
Sbjct: 272 KAIQKRRQSQEK---IDDILQTLLDATYK--DGRPLTDDEVAGMLIGLLLAGQHTSSTTS 326
Query: 235 TVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVV 294
+ L +Q K Y E K+VCG++ + Q L + +KETLRL P ++
Sbjct: 327 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM 386
Query: 295 LRKTENEIKLKSYTI-PANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAF 353
+R + YTI P + C+ W + F P+R+L+ + A+
Sbjct: 387 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSW-VERLDFNPDRYLQDNPASGEKFAY 445
Query: 354 AGFSVGKRNCIGKTYALISMKTTLVHLLRRYK 385
F G+ CIG+ +A + +KT +LR Y+
Sbjct: 446 VPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 477
>BC033691-1|AAH33691.1| 504|Homo sapiens cytochrome P450, family 2,
subfamily S, polypeptide 1 protein.
Length = 504
Score = 79.0 bits (186), Expect = 3e-14
Identities = 85/363 (23%), Positives = 149/363 (41%), Gaps = 22/363 (6%)
Query: 34 GDGLVTSSGETWKRHRKLLNPAFSQQMLNIYT--VVFNRESRNLISAIEIQMKSGPVLIS 91
G G+ S+GE W++ RK A + + E+R L+ + + P S
Sbjct: 113 GHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQ-GTEGRPFDPS 171
Query: 92 AAFKEMALKALLSTAFGIEV--EECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S FG+ E+ +F A ++ V ++ Q + F + L
Sbjct: 172 LLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQT---YEMFSWFLR 228
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
L +L+ ++T++ + + Q+ N AS + LLK +E
Sbjct: 229 PLPGPHKQLLHHVSTLAAFTV-------RQVQQHQGNLDASGPARDLVDAFLLKMAQEEQ 281
Query: 210 -----FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDA 264
FT+K + V L+F G+ T S + ++LL YP +Q V +E+ G A
Sbjct: 282 NPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQA 341
Query: 265 DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT-ENEIKLKSYTIPANSNCMLGIYGLN 323
RL YT+AVL E RL + P+ + +T + + YT+P + + +
Sbjct: 342 P-SLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSIL 400
Query: 324 RHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRR 383
P F P+R+L+ G AF FS+GKR C+G+ A + +L+
Sbjct: 401 HDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQA 460
Query: 384 YKV 386
+ +
Sbjct: 461 FSL 463
>AY358603-1|AAQ88966.1| 504|Homo sapiens Cytochrome p450 protein.
Length = 504
Score = 79.0 bits (186), Expect = 3e-14
Identities = 85/363 (23%), Positives = 149/363 (41%), Gaps = 22/363 (6%)
Query: 34 GDGLVTSSGETWKRHRKLLNPAFSQQMLNIYT--VVFNRESRNLISAIEIQMKSGPVLIS 91
G G+ S+GE W++ RK A + + E+R L+ + + P S
Sbjct: 113 GHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQ-GTEGRPFDPS 171
Query: 92 AAFKEMALKALLSTAFGIEV--EECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S FG+ E+ +F A ++ V ++ Q + F + L
Sbjct: 172 LLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQT---YEMFSWFLR 228
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
L +L+ ++T++ + + Q+ N AS + LLK +E
Sbjct: 229 PLPGPHKQLLHHVSTLAAFTV-------RQVQQHQGNLDASGPARDLVDAFLLKMAQEEQ 281
Query: 210 -----FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDA 264
FT+K + V L+F G+ T S + ++LL YP +Q V +E+ G A
Sbjct: 282 NPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQA 341
Query: 265 DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT-ENEIKLKSYTIPANSNCMLGIYGLN 323
RL YT+AVL E RL + P+ + +T + + YT+P + + +
Sbjct: 342 P-SLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSIL 400
Query: 324 RHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRR 383
P F P+R+L+ G AF FS+GKR C+G+ A + +L+
Sbjct: 401 HDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQA 460
Query: 384 YKV 386
+ +
Sbjct: 461 FSL 463
>AK027605-1|BAB55227.1| 564|Homo sapiens protein ( Homo sapiens
cDNA FLJ14699 fis, clone NT2RP2006571, moderately
similar to CYTOCHROME P450 2G1 (EC 1.14.14.1). ).
Length = 564
Score = 79.0 bits (186), Expect = 3e-14
Identities = 85/363 (23%), Positives = 149/363 (41%), Gaps = 22/363 (6%)
Query: 34 GDGLVTSSGETWKRHRKLLNPAFSQQMLNIYT--VVFNRESRNLISAIEIQMKSGPVLIS 91
G G+ S+GE W++ RK A + + E+R L+ + + P S
Sbjct: 113 GHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQ-GTEGRPFDPS 171
Query: 92 AAFKEMALKALLSTAFGIEV--EECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S FG+ E+ +F A ++ V ++ Q + F + L
Sbjct: 172 LLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQT---YEMFSWFLR 228
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
L +L+ ++T++ + + Q+ N AS + LLK +E
Sbjct: 229 PLPGPHKQLLHHVSTLAAFTV-------RQVQQHQGNLDASGPARDLVDAFLLKMAQEEQ 281
Query: 210 -----FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDA 264
FT+K + V L+F G+ T S + ++LL YP +Q V +E+ G A
Sbjct: 282 NPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQA 341
Query: 265 DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT-ENEIKLKSYTIPANSNCMLGIYGLN 323
RL YT+AVL E RL + P+ + +T + + YT+P + + +
Sbjct: 342 P-SLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSIL 400
Query: 324 RHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRR 383
P F P+R+L+ G AF FS+GKR C+G+ A + +L+
Sbjct: 401 HDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQA 460
Query: 384 YKV 386
+ +
Sbjct: 461 FSL 463
>AF335278-1|AAK13498.1| 504|Homo sapiens cytochrome P450 2S1
protein.
Length = 504
Score = 79.0 bits (186), Expect = 3e-14
Identities = 85/363 (23%), Positives = 149/363 (41%), Gaps = 22/363 (6%)
Query: 34 GDGLVTSSGETWKRHRKLLNPAFSQQMLNIYT--VVFNRESRNLISAIEIQMKSGPVLIS 91
G G+ S+GE W++ RK A + + E+R L+ + + P S
Sbjct: 113 GHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQ-GTEGRPFDPS 171
Query: 92 AAFKEMALKALLSTAFGIEV--EECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S FG+ E+ +F A ++ V ++ Q + F + L
Sbjct: 172 LLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQT---YEMFSWFLR 228
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
L +L+ ++T++ + + Q+ N AS + LLK +E
Sbjct: 229 PLPGPHKQLLHHVSTLAAFTV-------RQVQQHQGNLDASGPARDLVDAFLLKMAQEEQ 281
Query: 210 -----FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDA 264
FT+K + V L+F G+ T S + ++LL YP +Q V +E+ G A
Sbjct: 282 NPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQA 341
Query: 265 DVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKT-ENEIKLKSYTIPANSNCMLGIYGLN 323
RL YT+AVL E RL + P+ + +T + + YT+P + + +
Sbjct: 342 P-SLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSIL 400
Query: 324 RHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRR 383
P F P+R+L+ G AF FS+GKR C+G+ A + +L+
Sbjct: 401 HDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQA 460
Query: 384 YKV 386
+ +
Sbjct: 461 FSL 463
>AC000120-2|AAB46356.1| 509|Homo sapiens unknown protein.
Length = 509
Score = 79.0 bits (186), Expect = 3e-14
Identities = 56/212 (26%), Positives = 95/212 (44%), Gaps = 7/212 (3%)
Query: 175 RALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIM 234
+A++ +++S E + Q++ D K D TD E+ + L+ G TSS
Sbjct: 272 KAIQKRRQSQEK---IDDILQTLLDATYK--DGRPLTDDEVAGMLIGLLLAGQHTSSTTS 326
Query: 235 TVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVV 294
+ L +Q K Y E K+VCG++ + Q L + +KETLRL P ++
Sbjct: 327 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIM 386
Query: 295 LRKTENEIKLKSYTI-PANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAF 353
+R + YTI P + C+ W + F P+R+L+ + A+
Sbjct: 387 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSW-VERLDFNPDRYLQDNPASGEKFAY 445
Query: 354 AGFSVGKRNCIGKTYALISMKTTLVHLLRRYK 385
F G+ CIG+ +A + +KT +LR Y+
Sbjct: 446 VPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 477
>M80647-1|AAA60618.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>BC041157-1|AAH41157.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A)
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>BC014117-1|AAH14117.1| 466|Homo sapiens TBXAS1 protein protein.
Length = 466
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 260 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 319
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 320 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 379
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 380 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 439
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 440 ETQVPLQLESKSALGPKNGVYIKIVSR 466
>AK223466-1|BAD97186.1| 534|Homo sapiens thromboxane A synthase 1
(platelet, cytochrome P450, family 5, subfamily A) iso
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>AF233622-1|AAF99276.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAEDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>AF233620-1|AAF99274.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>AF233619-1|AAF99273.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>AF233618-1|AAF99272.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>AF233617-1|AAF99271.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>AF233616-1|AAF99270.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>AF233615-1|AAF99269.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 78.6 bits (185), Expect = 4e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>D34625-1|BAA07011.1| 533|Homo sapiens thromboxane synthase
protein.
Length = 533
Score = 78.2 bits (184), Expect = 5e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 327 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 386
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 387 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 446
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 447 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVHLGLLEVKLTLLHVLHKFRFQACP 506
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 507 ETQVPLQLESKSALGPKNGVYIKIVSR 533
>AK090886-1|BAC03539.1| 337|Homo sapiens protein ( Homo sapiens
cDNA FLJ33567 fis, clone BRAMY2010272, highly similar to
Homo sapiens cholesterol 24-hydroxylase mRNA. ).
Length = 337
Score = 78.2 bits (184), Expect = 5e-14
Identities = 81/317 (25%), Positives = 129/317 (40%), Gaps = 27/317 (8%)
Query: 68 FNRESRNLISAIEIQMKSG-PVLISAAFKEMALKALLSTAFGIEVEECDFNQKYMHAVDE 126
FN ++ L+ +E + PV + A+ L AFG+E QK + +
Sbjct: 4 FNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVK 63
Query: 127 VMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHEN 186
+M +N L F+ ++ E I + + + +R ALK +E +
Sbjct: 64 LMLEGITASRNTLA--KFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPAD 121
Query: 187 GCASEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPE 246
K + + DDE D + T G +TS+ + VM L PE
Sbjct: 122 ILTQILKAEEGAQ------DDEGLLDNFV-----TFFIAGHETSANHLAFTVMELSRQPE 170
Query: 247 IQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKS 306
I ++ E+ V G S +D RL Y VLKE+LRLYP R E E +
Sbjct: 171 IVARLQAEVDEVIG-SKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG 229
Query: 307 YTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGK 366
++ Y + R + D TF P+R+ G P + FS+G R+CIG+
Sbjct: 230 FST----------YVMGRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQ 277
Query: 367 TYALISMKTTLVHLLRR 383
+A + +K + LL+R
Sbjct: 278 QFAQMEVKVVMAKLLQR 294
>AF233623-1|AAF99277.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 78.2 bits (184), Expect = 5e-14
Identities = 51/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPKTFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>X71480-1|CAA50586.1| 141|Homo sapiens cytochrome P450 protein.
Length = 141
Score = 77.8 bits (183), Expect = 7e-14
Identities = 45/144 (31%), Positives = 73/144 (50%), Gaps = 4/144 (2%)
Query: 221 TLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAV 280
T +F G DT++ ++ ++ L ++P+ Q++ +EI + GD A + ++ YT
Sbjct: 1 TFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMC 59
Query: 281 LKETLRLYPITPVVLRKTENEIKL-KSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPER 339
+KE LRLYP P + R+ + ++P ML IYGL+ +P P+ F P R
Sbjct: 60 IKEALRLYPPVPGISRELSTPVTFPDGRSLPKGITVMLSIYGLHHNPKVWPNPEVFDPSR 119
Query: 340 WLELGGVPDDPNAFAGFSVGKRNC 363
+ G +AF FS G RNC
Sbjct: 120 FAP--GSAQHSHAFLPFSGGSRNC 141
>DQ282151-1|ABB77899.1| 496|Homo sapiens cytochrome P450 2D6
protein.
Length = 496
Score = 77.8 bits (183), Expect = 7e-14
Identities = 52/190 (27%), Positives = 90/190 (47%), Gaps = 4/190 (2%)
Query: 197 MSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIK 256
++++ KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI
Sbjct: 276 LAEMEAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEID 335
Query: 257 SVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNC 315
V G + + YT AV+ E R I P+ V T +I+++ + IP +
Sbjct: 336 DVIGQVRRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTL 394
Query: 316 MLGIYG-LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMK 374
+ + L VW F PE +L+ G P AF FS G+R C+G+ A + +
Sbjct: 395 ITNLSSVLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELF 453
Query: 375 TTLVHLLRRY 384
LL+ +
Sbjct: 454 LFFTSLLQHF 463
>AJ563378-3|CAD91347.1| 173|Homo sapiens hypothetical protein
protein.
Length = 173
Score = 77.4 bits (182), Expect = 9e-14
Identities = 44/145 (30%), Positives = 75/145 (51%), Gaps = 4/145 (2%)
Query: 273 RLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDA 332
++ Y + V+ ETLRL+P+ + R + ++++ IP S ++ Y L+ P + +
Sbjct: 23 QMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEP 82
Query: 333 HTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADIS 391
FRPER+ + DP + F G RNCIG +AL++MK L+ +L+ + +
Sbjct: 83 EEFRPERFSKKKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 141
Query: 392 KIEFKLD--ALMVPSDNCYAKFESR 414
+I KLD L+ P K +SR
Sbjct: 142 QIPLKLDTQGLLQPEKPIVLKVDSR 166
>AJ563378-2|CAD91647.1| 160|Homo sapiens cytochrome P450 protein.
Length = 160
Score = 77.4 bits (182), Expect = 9e-14
Identities = 44/145 (30%), Positives = 75/145 (51%), Gaps = 4/145 (2%)
Query: 273 RLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDA 332
++ Y + V+ ETLRL+P+ + R + ++++ IP S ++ Y L+ P + +
Sbjct: 10 QMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEP 69
Query: 333 HTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV-TADIS 391
FRPER+ + DP + F G RNCIG +AL++MK L+ +L+ + +
Sbjct: 70 EEFRPERFSKKKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 128
Query: 392 KIEFKLD--ALMVPSDNCYAKFESR 414
+I KLD L+ P K +SR
Sbjct: 129 QIPLKLDTQGLLQPEKPIVLKVDSR 153
>AF233621-1|AAF99275.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 77.4 bits (182), Expect = 9e-14
Identities = 50/207 (24%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ +L + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYVLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
TF PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>U51692-1|AAC50951.1| 503|Homo sapiens lanosterol 14-alpha
demethylase protein.
Length = 503
Score = 77.0 bits (181), Expect = 1e-13
Identities = 53/199 (26%), Positives = 87/199 (43%), Gaps = 4/199 (2%)
Query: 190 SEKKTQSMSDLLLKGL--DDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEI 247
S++K + LL D TD E+ + L+ G TSS + L +
Sbjct: 274 SQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTL 333
Query: 248 QDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSY 307
Q K Y E K+VCG++ + Q L + ++ETLRL P +++R + Y
Sbjct: 334 QKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIRETLRLRPPIMIMMRMARTPQTVAGY 393
Query: 308 TI-PANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGK 366
TI P + C+ W + F P+R+L+ + A+ F G+ CIG+
Sbjct: 394 TIPPGHQVCVSPTVNQRLKDSW-VERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGE 452
Query: 367 TYALISMKTTLVHLLRRYK 385
+A + +KT +LR Y+
Sbjct: 453 NFAYVQIKTIWSTMLRLYE 471
>S46963-1|AAB23864.2| 477|Homo sapiens cytochrome P-450 protein.
Length = 477
Score = 76.6 bits (180), Expect = 2e-13
Identities = 82/364 (22%), Positives = 155/364 (42%), Gaps = 25/364 (6%)
Query: 34 GDGLVTSSGETWKRHRK---LLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLI 90
G G+V S+G+ WK R+ + F +I V E+R L+ + + K+ P
Sbjct: 96 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV-QEEARCLVEELR-KTKASPCDP 153
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFN-QKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S F + D M ++E + +L+ + I + N+F +
Sbjct: 154 TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPW--IQICNNFSPIID 211
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
++L++ + M + ++ +K QES + Q D L ++ E
Sbjct: 212 YFPGTHNKLLKNVAFMKSYILEK----VKEHQESMDMN-----NPQDFIDCFLMKMEKEK 262
Query: 210 ------FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSD 263
FT + + N L G++T+S + ++LL +PE+ KV +EI+ V G +
Sbjct: 263 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 322
Query: 264 ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGL 322
+ + + YT+AV+ E R + P L +IK ++Y IP + ++ + +
Sbjct: 323 SPCMQ-DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 381
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
P+ F P +L+ GG F FS GKR C+G+ A + + L +L+
Sbjct: 382 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 441
Query: 383 RYKV 386
+ +
Sbjct: 442 NFNL 445
>M33388-1|AAA53500.1| 497|Homo sapiens cytochrome P450 IID6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>M33189-1|AAA35737.1| 500|Homo sapiens protein ( Human debrisoquine
4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
cds. ).
Length = 500
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 286 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 345
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 346 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 404
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 405 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 463
Query: 381 LRRY 384
L+ +
Sbjct: 464 LQHF 467
>M24499-1|AAA36403.1| 373|Homo sapiens cytochrome P450db1 protein.
Length = 373
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 159 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 218
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 219 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 277
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 278 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 336
Query: 381 LRRY 384
L+ +
Sbjct: 337 LQHF 340
>M21940-1|AAA52159.1| 383|Homo sapiens CYP2C protein.
Length = 383
Score = 76.6 bits (180), Expect = 2e-13
Identities = 82/364 (22%), Positives = 155/364 (42%), Gaps = 25/364 (6%)
Query: 34 GDGLVTSSGETWKRHRK---LLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLI 90
G G+V S+G+ WK R+ + F +I V E+R L+ + + K+ P
Sbjct: 2 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV-QEEARCLVEELR-KTKASPCDP 59
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFN-QKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S F + D M ++E + +L+ + I + N+F +
Sbjct: 60 TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPW--IQICNNFSPIID 117
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
++L++ + M + ++ +K QES + Q D L ++ E
Sbjct: 118 YFPGTHNKLLKNVAFMKSYILEK----VKEHQESMDMN-----NPQDFIDCFLMKMEKEK 168
Query: 210 ------FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSD 263
FT + + N L G++T+S + ++LL +PE+ KV +EI+ V G +
Sbjct: 169 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 228
Query: 264 ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGL 322
+ + + YT+AV+ E R + P L +IK ++Y IP + ++ + +
Sbjct: 229 SPCMQ-DRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 287
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
P+ F P +L+ GG F FS GKR C+G+ A + + L +L+
Sbjct: 288 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 347
Query: 383 RYKV 386
+ +
Sbjct: 348 NFNL 351
>D00173-1|BAA00123.1| 487|Homo sapiens cytochrome P-450 protein.
Length = 487
Score = 76.6 bits (180), Expect = 2e-13
Identities = 82/364 (22%), Positives = 155/364 (42%), Gaps = 25/364 (6%)
Query: 34 GDGLVTSSGETWKRHRK---LLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLI 90
G G+V S+G+ WK R+ + F +I V E+R L+ + + K+ P
Sbjct: 106 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV-QEEARCLVEELR-KTKASPCDP 163
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFN-QKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S F + D M ++E + +L+ + I + N+F +
Sbjct: 164 TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPW--IQICNNFSPIID 221
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
++L++ + M + ++ +K QES + Q D L ++ E
Sbjct: 222 YFPGTHNKLLKNVAFMKSYILEK----VKEHQESMDMN-----NPQDFIDCFLMKMEKEK 272
Query: 210 ------FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSD 263
FT + + N L G++T+S + ++LL +PE+ KV +EI+ V G +
Sbjct: 273 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 332
Query: 264 ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGL 322
+ + + YT+AV+ E R + P L +IK ++Y IP + ++ + +
Sbjct: 333 SPCMQ-DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 391
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
P+ F P +L+ GG F FS GKR C+G+ A + + L +L+
Sbjct: 392 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 451
Query: 383 RYKV 386
+ +
Sbjct: 452 NFNL 455
>DQ282154-1|ABB77902.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282152-1|ABB77900.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282146-1|ABB77897.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282145-1|ABB77896.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282144-1|ABB77895.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ211354-2|ABB01372.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ211353-2|ABB01371.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ211353-1|ABB01370.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>BC125054-1|AAI25055.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 76.6 bits (180), Expect = 2e-13
Identities = 82/364 (22%), Positives = 155/364 (42%), Gaps = 25/364 (6%)
Query: 34 GDGLVTSSGETWKRHRK---LLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLI 90
G G+V S+G+ WK R+ + F +I V E+R L+ + + K+ P
Sbjct: 109 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV-QEEARCLVEELR-KTKASPCDP 166
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFN-QKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S F + D M ++E + +L+ + I + N+F +
Sbjct: 167 TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPW--IQICNNFSPIID 224
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
++L++ + M + ++ +K QES + Q D L ++ E
Sbjct: 225 YFPGTHNKLLKNVAFMKSYILEK----VKEHQESMDMN-----NPQDFIDCFLMKMEKEK 275
Query: 210 ------FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSD 263
FT + + N L G++T+S + ++LL +PE+ KV +EI+ V G +
Sbjct: 276 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 335
Query: 264 ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGL 322
+ + + YT+AV+ E R + P L +IK ++Y IP + ++ + +
Sbjct: 336 SPCMQ-DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 394
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
P+ F P +L+ GG F FS GKR C+G+ A + + L +L+
Sbjct: 395 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 454
Query: 383 RYKV 386
+ +
Sbjct: 455 NFNL 458
>BC075024-1|AAH75024.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>BC075023-1|AAH75023.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>AY702706-1|AAT94065.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 76.6 bits (180), Expect = 2e-13
Identities = 82/364 (22%), Positives = 155/364 (42%), Gaps = 25/364 (6%)
Query: 34 GDGLVTSSGETWKRHRK---LLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLI 90
G G+V S+G+ WK R+ + F +I V E+R L+ + + K+ P
Sbjct: 109 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV-QEEARCLVEELR-KTKASPCDP 166
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFN-QKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S F + D M ++E + +L+ + I + N+F +
Sbjct: 167 TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPW--IQICNNFSPIID 224
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
++L++ + M + ++ +K QES + Q D L ++ E
Sbjct: 225 YFPGTHNKLLKNVAFMKSYILEK----VKEHQESMDMN-----NPQDFIDCFLMKMEKEK 275
Query: 210 ------FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSD 263
FT + + N L G++T+S + ++LL +PE+ KV +EI+ V G +
Sbjct: 276 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 335
Query: 264 ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGL 322
+ + + YT+AV+ E R + P L +IK ++Y IP + ++ + +
Sbjct: 336 SPCMQ-DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 394
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
P+ F P +L+ GG F FS GKR C+G+ A + + L +L+
Sbjct: 395 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 454
Query: 383 RYKV 386
+ +
Sbjct: 455 NFNL 458
>AY545216-1|AAS55001.1| 497|Homo sapiens cytochrome P4502D6
protein.
Length = 497
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>AY341248-1|AAP88931.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 76.6 bits (180), Expect = 2e-13
Identities = 82/364 (22%), Positives = 155/364 (42%), Gaps = 25/364 (6%)
Query: 34 GDGLVTSSGETWKRHRK---LLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLI 90
G G+V S+G+ WK R+ + F +I V E+R L+ + + K+ P
Sbjct: 109 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV-QEEARCLVEELR-KTKASPCDP 166
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFN-QKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S F + D M ++E + +L+ + I + N+F +
Sbjct: 167 TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPW--IQICNNFSPIID 224
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
++L++ + M + ++ +K QES + Q D L ++ E
Sbjct: 225 YFPGTHNKLLKNVAFMKSYILEK----VKEHQESMDMN-----NPQDFIDCFLMKMEKEK 275
Query: 210 ------FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSD 263
FT + + N L G++T+S + ++LL +PE+ KV +EI+ V G +
Sbjct: 276 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 335
Query: 264 ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGL 322
+ + + YT+AV+ E R + P L +IK ++Y IP + ++ + +
Sbjct: 336 SPCMQ-DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 394
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
P+ F P +L+ GG F FS GKR C+G+ A + + L +L+
Sbjct: 395 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 454
Query: 383 RYKV 386
+ +
Sbjct: 455 NFNL 458
>AL359672-1|CAH71303.1| 490|Homo sapiens cytochrome P450, family 2,
subfamily C, polypeptide 9 protein.
Length = 490
Score = 76.6 bits (180), Expect = 2e-13
Identities = 82/364 (22%), Positives = 155/364 (42%), Gaps = 25/364 (6%)
Query: 34 GDGLVTSSGETWKRHRK---LLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLI 90
G G+V S+G+ WK R+ + F +I V E+R L+ + + K+ P
Sbjct: 109 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV-QEEARCLVEELR-KTKASPCDP 166
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFN-QKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S F + D M ++E + +L+ + I + N+F +
Sbjct: 167 TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPW--IQICNNFSPIID 224
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
++L++ + M + ++ +K QES + Q D L ++ E
Sbjct: 225 YFPGTHNKLLKNVAFMKSYILEK----VKEHQESMDMN-----NPQDFIDCFLMKMEKEK 275
Query: 210 ------FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSD 263
FT + + N L G++T+S + ++LL +PE+ KV +EI+ V G +
Sbjct: 276 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 335
Query: 264 ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGL 322
+ + + YT+AV+ E R + P L +IK ++Y IP + ++ + +
Sbjct: 336 SPCMQ-DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 394
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
P+ F P +L+ GG F FS GKR C+G+ A + + L +L+
Sbjct: 395 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 454
Query: 383 RYKV 386
+ +
Sbjct: 455 NFNL 458
>AF233624-1|AAF99278.1| 534|Homo sapiens thromboxane synthase
protein.
Length = 534
Score = 76.6 bits (180), Expect = 2e-13
Identities = 50/207 (24%), Positives = 92/207 (44%), Gaps = 3/207 (1%)
Query: 211 TDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQ 270
T EI + + G + + ++ LL + P+ Q+K+ +E+ A
Sbjct: 328 TVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSL 387
Query: 271 HPRLVYTEAVLKETLRLYPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGP 330
L Y + V+ ETLR+YP R+ + ++ IPA + + + L+ P P
Sbjct: 388 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWP 447
Query: 331 DAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA-D 389
F PER+ P + F G R+C+G L+ +K TL+H+L +++ A
Sbjct: 448 SPENFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 507
Query: 390 ISKIEFKLD--ALMVPSDNCYAKFESR 414
+++ +L+ + + P + Y K SR
Sbjct: 508 ETQVPLQLESKSALGPKNGVYIKIVSR 534
>AB209492-1|BAD92729.1| 566|Homo sapiens Debrisoquine 4-hydroxylase
mutant allele variant protein.
Length = 566
Score = 76.6 bits (180), Expect = 2e-13
Identities = 52/184 (28%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 352 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 411
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 412 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 470
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 471 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 529
Query: 381 LRRY 384
L+ +
Sbjct: 530 LQHF 533
>AY696295-1|AAU10524.1| 292|Homo sapiens cytochrome P450 protein.
Length = 292
Score = 75.8 bits (178), Expect = 3e-13
Identities = 44/180 (24%), Positives = 89/180 (49%), Gaps = 7/180 (3%)
Query: 26 YQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKS 85
++ +W+G GLVT G WK+HR+++ P F+ +L I+ + ++ R +++ E +
Sbjct: 114 HKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSKSVRMMLNKWEEHIAH 173
Query: 86 GPVL-ISAAFKEMALKALLSTAFGIE--VEECDFNQKYMHAVDEVMAVLTRRFQNILLHN 142
L + M L +++ AF + ++ Y+ AV + + +R N L HN
Sbjct: 174 NSRLELFQHVSLMTLHSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHN 233
Query: 143 SFVYKLSALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLL 202
V+K S+ + + + + + KVI ++ +LK+K + ++K+ Q D+LL
Sbjct: 234 DLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQD----TTQKRRQDFLDILL 289
>X65962-1|CAA46778.1| 356|Homo sapiens cytochrome P-450 II C
protein.
Length = 356
Score = 75.4 bits (177), Expect = 4e-13
Identities = 61/239 (25%), Positives = 108/239 (45%), Gaps = 12/239 (5%)
Query: 158 LIETITTMSNKVINS---KRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKE 214
LI+ NKV+ + R ++ K + H+ + L+K ++ E K
Sbjct: 88 LIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIK-MEQEKDNQKS 146
Query: 215 ---IRNEVDT---LIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDK 268
I N V T L+ G++T+S + ++LL +PE+ KV +EI+ V G + + +
Sbjct: 147 EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ 206
Query: 269 LQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGLNRHPV 327
+ YT+AV+ E R + P L +IK ++Y IP + + + +
Sbjct: 207 -DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDIKFRNYLIPKGTTILTSLTSVLHDNK 265
Query: 328 WGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
P+ F P +L+ GG N F FS GKR C+G+ A + + L +L+ + +
Sbjct: 266 EFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 324
>X08006-1|CAA30807.1| 497|Homo sapiens cytochrome P450 db1 protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 51/184 (27%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ + T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>M20403-1|AAA52153.1| 497|Homo sapiens CYP2D protein.
Length = 497
Score = 75.4 bits (177), Expect = 4e-13
Identities = 51/184 (27%), Positives = 86/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ +R V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ + T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>AL135960-9|CAI19736.1| 421|Homo sapiens cytochrome P450, family 4,
subfamily A, polypeptide 22 protein.
Length = 421
Score = 75.4 bits (177), Expect = 4e-13
Identities = 43/135 (31%), Positives = 68/135 (50%), Gaps = 3/135 (2%)
Query: 273 RLVYTEAVLKETLRLYPITPVVLRKTENEIKLKS-YTIPANSNCMLGIYGLNRHPVWGPD 331
++ YT +KE LRLYP P + R+ + ++P +L IYGL+ +P P+
Sbjct: 270 QMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPN 329
Query: 332 AHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTADIS 391
F P R+ G +AF FS G RNCIGK +A+ +K L R+++ D +
Sbjct: 330 LEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPT 387
Query: 392 KIEFKLDALMVPSDN 406
+I + L++ S N
Sbjct: 388 RIPIPMARLVLKSKN 402
Score = 45.2 bits (102), Expect = 4e-04
Identities = 24/86 (27%), Positives = 44/86 (51%), Gaps = 1/86 (1%)
Query: 23 HFFYQFASNWLGDGLVTSSGETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISA-IEI 81
H Y+F + +G GL+ +G+TW +HR++L PAF +L Y + R ++ E+
Sbjct: 117 HGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEEL 176
Query: 82 QMKSGPVLISAAFKEMALKALLSTAF 107
+ P+ + M L ++ +AF
Sbjct: 177 LGQDSPLEVFQHVSLMTLDTIMKSAF 202
>X55764-1|CAA39290.1| 503|Homo sapiens protein ( Human mRNA for
cytochrome P-450 (11 Beta). ).
Length = 503
Score = 74.9 bits (176), Expect = 5e-13
Identities = 47/160 (29%), Positives = 75/160 (46%), Gaps = 4/160 (2%)
Query: 228 DTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRL 287
DT+ + + + L P +Q + QE + K L A LKETLRL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 288 YPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVP 347
YP+ + R +++ L++Y IPA + + +Y L R+P P + P+RWL++ G
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 433
Query: 348 DDPNAF-AGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
N + F G R C+G+ A M L H+L+ +V
Sbjct: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
>M32879-1|AAA52149.1| 503|Homo sapiens CYP11B1 protein.
Length = 503
Score = 74.9 bits (176), Expect = 5e-13
Identities = 47/160 (29%), Positives = 75/160 (46%), Gaps = 4/160 (2%)
Query: 228 DTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRL 287
DT+ + + + L P +Q + QE + K L A LKETLRL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 288 YPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVP 347
YP+ + R +++ L++Y IPA + + +Y L R+P P + P+RWL++ G
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 433
Query: 348 DDPNAF-AGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
N + F G R C+G+ A M L H+L+ +V
Sbjct: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
>BC096287-1|AAH96287.1| 503|Homo sapiens cytochrome P450, family
11, subfamily B, polypeptide 1 protein.
Length = 503
Score = 74.9 bits (176), Expect = 5e-13
Identities = 47/160 (29%), Positives = 75/160 (46%), Gaps = 4/160 (2%)
Query: 228 DTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRL 287
DT+ + + + L P +Q + QE + K L A LKETLRL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 288 YPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVP 347
YP+ + R +++ L++Y IPA + + +Y L R+P P + P+RWL++ G
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 433
Query: 348 DDPNAF-AGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
N + F G R C+G+ A M L H+L+ +V
Sbjct: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
>BC096285-1|AAH96285.1| 574|Homo sapiens CYP11B1 protein protein.
Length = 574
Score = 74.9 bits (176), Expect = 5e-13
Identities = 47/160 (29%), Positives = 75/160 (46%), Gaps = 4/160 (2%)
Query: 228 DTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRL 287
DT+ + + + L P +Q + QE + K L A LKETLRL
Sbjct: 388 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 446
Query: 288 YPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVP 347
YP+ + R +++ L++Y IPA + + +Y L R+P P + P+RWL++ G
Sbjct: 447 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 504
Query: 348 DDPNAF-AGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
N + F G R C+G+ A M L H+L+ +V
Sbjct: 505 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 544
>AF478474-1|AAL84813.1| 503|Homo sapiens mutated cytochrome
P-450c11 protein protein.
Length = 503
Score = 74.9 bits (176), Expect = 5e-13
Identities = 47/160 (29%), Positives = 75/160 (46%), Gaps = 4/160 (2%)
Query: 228 DTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRL 287
DT+ + + + L P +Q + QE + K L A LKETLRL
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 288 YPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVP 347
YP+ + R +++ L++Y IPA + + +Y L R+P P + P+RWL++ G
Sbjct: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG-- 433
Query: 348 DDPNAF-AGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
N + F G R C+G+ A M L H+L+ +V
Sbjct: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
>M32881-1|AAA35741.1| 503|Homo sapiens protein ( Human steroid
11-beta-hydroxylase-like-enzyme (CYP11B2) gene, exon 9.
).
Length = 503
Score = 74.5 bits (175), Expect = 6e-13
Identities = 45/159 (28%), Positives = 77/159 (48%), Gaps = 2/159 (1%)
Query: 228 DTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRL 287
DT++ + + + L P++Q + +E + K L A LKETLRL
Sbjct: 317 DTTAFPLLMTLFELARNPDVQQILRKESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 288 YPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVP 347
YP+ + R +++ L++Y IPA + + +Y L R+ P + P+RWL++ G
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435
Query: 348 DDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
+ + F G R C+G+ A M L H+L+R+ V
Sbjct: 436 RNLH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKRFLV 473
>M61858-1|AAA52145.1| 370|Homo sapiens CYP2C17 protein.
Length = 370
Score = 74.1 bits (174), Expect = 8e-13
Identities = 46/178 (25%), Positives = 85/178 (47%), Gaps = 2/178 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
FT + + V + G++T+S + ++LL +PE+ KV +EI+ V G + + +
Sbjct: 162 FTVESLIATVTDMFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ- 220
Query: 270 QHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGLNRHPVW 328
+ YT+AV+ E R + P L ++K ++Y IP + + + +
Sbjct: 221 DRSHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 280
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
P+ F P +L+ GG N F FS GKR C+G+ A + + L +L+ + +
Sbjct: 281 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 338
>M29874-1|AAA52144.1| 491|Homo sapiens CYP2B protein.
Length = 491
Score = 74.1 bits (174), Expect = 8e-13
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 2/189 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F+ + + +L F G++T+S + +L+ YP + ++VY+EI+ V G +
Sbjct: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP-ELH 341
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
++ YTEAV+ E R + P+ V + Y IP ++ L + P +
Sbjct: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
F P+ +L+ G AF FS+GKR C+G+ A + +L+ + + +
Sbjct: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461
Query: 389 DISKIEFKL 397
++ + L
Sbjct: 462 PVAPEDIDL 470
>DQ298753-1|ABB84469.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 74.1 bits (174), Expect = 8e-13
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 2/189 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F+ + + +L F G++T+S + +L+ YP + ++VY+EI+ V G +
Sbjct: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP-ELH 341
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
++ YTEAV+ E R + P+ V + Y IP ++ L + P +
Sbjct: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
F P+ +L+ G AF FS+GKR C+G+ A + +L+ + + +
Sbjct: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461
Query: 389 DISKIEFKL 397
++ + L
Sbjct: 462 PVAPEDIDL 470
>BC067431-1|AAH67431.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 74.1 bits (174), Expect = 8e-13
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 2/189 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F+ + + +L F G++T+S + +L+ YP + ++VY+EI+ V G +
Sbjct: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP-ELH 341
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
++ YTEAV+ E R + P+ V + Y IP ++ L + P +
Sbjct: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
F P+ +L+ G AF FS+GKR C+G+ A + +L+ + + +
Sbjct: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461
Query: 389 DISKIEFKL 397
++ + L
Sbjct: 462 PVAPEDIDL 470
>BC067430-1|AAH67430.1| 491|Homo sapiens cytochrome P450, family 2,
subfamily B, polypeptide 6 protein.
Length = 491
Score = 74.1 bits (174), Expect = 8e-13
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 2/189 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F+ + + +L F G++T+S + +L+ YP + ++VY+EI+ V G +
Sbjct: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP-ELH 341
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
++ YTEAV+ E R + P+ V + Y IP ++ L + P +
Sbjct: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
F P+ +L+ G AF FS+GKR C+G+ A + +L+ + + +
Sbjct: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461
Query: 389 DISKIEFKL 397
++ + L
Sbjct: 462 PVAPEDIDL 470
>AF182277-1|AAF13602.1| 491|Homo sapiens cytochrome P450-2B6
protein.
Length = 491
Score = 74.1 bits (174), Expect = 8e-13
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 2/189 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F+ + + +L F G++T+S + +L+ YP + ++VY+EI+ V G +
Sbjct: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP-ELH 341
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
++ YTEAV+ E R + P+ V + Y IP ++ L + P +
Sbjct: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
F P+ +L+ G AF FS+GKR C+G+ A + +L+ + + +
Sbjct: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461
Query: 389 DISKIEFKL 397
++ + L
Sbjct: 462 PVAPEDIDL 470
>AC023172-1|AAF32444.1| 491|Homo sapiens CYP2B6 protein.
Length = 491
Score = 74.1 bits (174), Expect = 8e-13
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 2/189 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
F+ + + +L F G++T+S + +L+ YP + ++VY+EI+ V G +
Sbjct: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP-ELH 341
Query: 270 QHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVW 328
++ YTEAV+ E R + P+ V + Y IP ++ L + P +
Sbjct: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKVTA 388
F P+ +L+ G AF FS+GKR C+G+ A + +L+ + + +
Sbjct: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461
Query: 389 DISKIEFKL 397
++ + L
Sbjct: 462 PVAPEDIDL 470
>X54741-1|CAA38539.1| 503|Homo sapiens aldosterone synthase
(P-450aldo) protein.
Length = 503
Score = 73.7 bits (173), Expect = 1e-12
Identities = 45/159 (28%), Positives = 76/159 (47%), Gaps = 2/159 (1%)
Query: 228 DTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRL 287
DT++ + + + L P++Q + QE + K L A LKETLRL
Sbjct: 317 DTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 288 YPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVP 347
YP+ + R +++ L++Y IPA + + +Y L R+ P + P+RWL++ G
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435
Query: 348 DDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
+ + F G R C+G+ A M L H+L+ + V
Sbjct: 436 RNFH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLV 473
>M21939-1|AAA52158.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 73.7 bits (173), Expect = 1e-12
Identities = 81/364 (22%), Positives = 154/364 (42%), Gaps = 25/364 (6%)
Query: 34 GDGLVTSSGETWKRHRK---LLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLI 90
G G+V S+G+ WK R+ + F +I V E+R L+ + + K+ P
Sbjct: 104 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV-QEEARCLVEELR-KTKASPCDP 161
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFN-QKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S F + D M ++E + +L+ + I + N+F +
Sbjct: 162 TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPW--IQICNNFSPIID 219
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
++L++ + M + ++ +K QES + Q D L ++ E
Sbjct: 220 YFPGTHNKLLKNVAFMKSYILEK----VKEHQESMDMN-----NPQDFIDCFLMKMEKEK 270
Query: 210 ------FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSD 263
FT + + N L G++T+S + ++LL +PE+ KV +EI+ V G +
Sbjct: 271 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 330
Query: 264 ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGL 322
+ + + YT+AV+ E R + P L +IK ++Y IP + ++ + +
Sbjct: 331 SPCMQ-DRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 389
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
P+ F P +L+ G F FS GKR C+G+ A + + L +L+
Sbjct: 390 LHDNKEFPNPEMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 449
Query: 383 RYKV 386
+ +
Sbjct: 450 NFNL 453
>M15331-1|AAA52157.1| 485|Homo sapiens CYP2C protein.
Length = 485
Score = 73.7 bits (173), Expect = 1e-12
Identities = 81/364 (22%), Positives = 154/364 (42%), Gaps = 25/364 (6%)
Query: 34 GDGLVTSSGETWKRHRK---LLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLI 90
G G+V S+G+ WK R+ + F +I V E+R L+ + + K+ P
Sbjct: 104 GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV-QEEARCLVEELR-KTKASPCDP 161
Query: 91 SAAFKEMALKALLSTAFGIEVEECDFN-QKYMHAVDEVMAVLTRRFQNILLHNSFVYKLS 149
+ + S F + D M ++E + +L+ + I + N+F +
Sbjct: 162 TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPW--IQICNNFSPIID 219
Query: 150 ALKKKEDELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEA 209
++L++ + M + ++ +K QES + Q D L ++ E
Sbjct: 220 YFPGTHNKLLKNVAFMKSYILEK----VKEHQESMDMN-----NPQDFIDCFLMKMEKEK 270
Query: 210 ------FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSD 263
FT + + N L G++T+S + ++LL +PE+ KV +EI+ V G +
Sbjct: 271 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 330
Query: 264 ADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGL 322
+ + + YT+AV+ E R + P L +IK ++Y IP + ++ + +
Sbjct: 331 SPCMQ-DRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 389
Query: 323 NRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLR 382
P+ F P +L+ G F FS GKR C+G+ A + + L +L+
Sbjct: 390 LHDNKEFPNPEMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 449
Query: 383 RYKV 386
+ +
Sbjct: 450 NFNL 453
>D13752-1|BAA02899.1| 503|Homo sapiens steroid 18-hydroxylase
protein.
Length = 503
Score = 73.7 bits (173), Expect = 1e-12
Identities = 45/159 (28%), Positives = 76/159 (47%), Gaps = 2/159 (1%)
Query: 228 DTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKLQHPRLVYTEAVLKETLRL 287
DT++ + + + L P++Q + QE + K L A LKETLRL
Sbjct: 317 DTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT-TELPLLRAALKETLRL 375
Query: 288 YPITPVVLRKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVP 347
YP+ + R +++ L++Y IPA + + +Y L R+ P + P+RWL++ G
Sbjct: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435
Query: 348 DDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
+ + F G R C+G+ A M L H+L+ + V
Sbjct: 436 RNFH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLV 473
>X58906-1|CAA41709.1| 495|Homo sapiens steroid 21-monooxygenase
protein.
Length = 495
Score = 73.3 bits (172), Expect = 1e-12
Identities = 78/351 (22%), Positives = 143/351 (40%), Gaps = 28/351 (7%)
Query: 45 WKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFKEMALKALLS 104
WK H+KL A + + V + ++ + Q + PV I F + +
Sbjct: 117 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGT-PVAIEEEFSLLTCSIICY 175
Query: 105 TAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNIL--------LHNSFVYKLSALKKKED 156
FG ++++ + Y + EV+ + I+ N + +L +K D
Sbjct: 176 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 235
Query: 157 ELIETITTMSNKVINSKRRALKNKQESHENGCASEKKTQSMSDLLLKGLDDEAFTDKEIR 216
++E + + + + ++ + G A + S LL+G A D
Sbjct: 236 HIVEMQLRQHKESLVAGQ--WRDMMDYMLQGVAQPSMEEG-SGQLLEGHVHMAAVD---- 288
Query: 217 NEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGD--SDADVDKLQHPRL 274
L+ G++T++ ++ V+ L +PEIQ ++ +E+ G S + V H RL
Sbjct: 289 -----LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDHARL 343
Query: 275 VYTEAVLKETLRLYPITPVVL-RKTENEIKLKSYTIPANSNCMLGIYGLNRHPVWGPDAH 333
A + E LRL P+ P+ L +T + Y IP + + + G + H
Sbjct: 344 PLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPH 403
Query: 334 TFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRY 384
F P+R+LE G + A A F G R C+G+ A + + L LL+ +
Sbjct: 404 EFWPDRFLEPG---KNSRALA-FGCGARVCLGEPLARLELFVVLTRLLQAF 450
>DQ282162-1|ABB77909.1| 500|Homo sapiens cytochrome P450 2D6
protein.
Length = 500
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 286 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 345
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 346 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 404
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 405 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 463
Query: 381 LRRY 384
L+ +
Sbjct: 464 LQHF 467
>DQ282160-1|ABB77908.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282159-1|ABB77907.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282158-1|ABB77906.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282157-1|ABB77905.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282156-1|ABB77904.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282155-1|ABB77903.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>DQ282147-1|ABB77898.1| 497|Homo sapiens cytochrome P450 2D6
protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>CR456430-1|CAG30316.1| 446|Homo sapiens CYP2D6 protein.
Length = 446
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 232 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 291
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 292 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 350
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 351 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 409
Query: 381 LRRY 384
L+ +
Sbjct: 410 LQHF 413
>BC126858-1|AAI26859.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>BC106758-1|AAI06759.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDEVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>BC106757-1|AAI06758.1| 446|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 446
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 232 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 291
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 292 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 350
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 351 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 409
Query: 381 LRRY 384
L+ +
Sbjct: 410 LQHF 413
>BC067432-1|AAH67432.1| 497|Homo sapiens cytochrome P450, family 2,
subfamily D, polypeptide 6 protein.
Length = 497
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 283 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 342
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 343 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 401
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 402 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 460
Query: 381 LRRY 384
L+ +
Sbjct: 461 LQHF 464
>BC066877-1|AAH66877.1| 446|Homo sapiens CYP2D6 protein protein.
Length = 446
Score = 73.3 bits (172), Expect = 1e-12
Identities = 51/184 (27%), Positives = 85/184 (46%), Gaps = 4/184 (2%)
Query: 203 KGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDS 262
KG + +F D+ + V L G T+S + ++L+ +P++Q +V QEI V G
Sbjct: 232 KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 291
Query: 263 DADVDKLQHPRLVYTEAVLKETLRLYPITPV-VLRKTENEIKLKSYTIPANSNCMLGIYG 321
+ + YT AV+ E R I P+ V T +I+++ + IP + + +
Sbjct: 292 RRP-EMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 350
Query: 322 -LNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHL 380
L VW F PE +L+ G P AF FS G+R C+G+ A + + L
Sbjct: 351 VLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 409
Query: 381 LRRY 384
L+ +
Sbjct: 410 LQHF 413
>M61854-1|AAB59426.1| 490|Homo sapiens cytochrome protein.
Length = 490
Score = 72.9 bits (171), Expect = 2e-12
Identities = 46/178 (25%), Positives = 85/178 (47%), Gaps = 2/178 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
FT + + L+ G++T+S + ++LL +PE+ KV +EI+ V G + + +
Sbjct: 282 FTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQ- 340
Query: 270 QHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGLNRHPVW 328
+ YT+AV+ E R + P L ++K ++Y IP + + + +
Sbjct: 341 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
P+ F P +L+ GG N F FS GKR C+G+ A + + L +L+ + +
Sbjct: 401 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458
>L39102-1|AAL31348.1| 217|Homo sapiens S-mephenytoin 4-hydroxylase
protein.
Length = 217
Score = 72.9 bits (171), Expect = 2e-12
Identities = 46/178 (25%), Positives = 85/178 (47%), Gaps = 2/178 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
FT + + L+ G++T+S + ++LL +PE+ KV +EI+ V G + + +
Sbjct: 9 FTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQ- 67
Query: 270 QHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGLNRHPVW 328
+ YT+AV+ E R + P L ++K ++Y IP + + + +
Sbjct: 68 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 127
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
P+ F P +L+ GG N F FS GKR C+G+ A + + L +L+ + +
Sbjct: 128 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 185
>L07093-1|AAA36660.1| 468|Homo sapiens cytochrome P450 protein.
Length = 468
Score = 72.9 bits (171), Expect = 2e-12
Identities = 46/178 (25%), Positives = 85/178 (47%), Gaps = 2/178 (1%)
Query: 210 FTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQEIKSVCGDSDADVDKL 269
FT + + L+ G++T+S + ++LL +PE+ KV +EI+ V G + + +
Sbjct: 260 FTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ- 318
Query: 270 QHPRLVYTEAVLKETLRLYPITPVVLRKTEN-EIKLKSYTIPANSNCMLGIYGLNRHPVW 328
+ YT+AV+ E R + P L ++K ++Y IP + + + +
Sbjct: 319 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 378
Query: 329 GPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCIGKTYALISMKTTLVHLLRRYKV 386
P+ F P +L+ GG N F FS GKR C+G+ A + + L +L+ + +
Sbjct: 379 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 436
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.318 0.133 0.384
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 55,964,926
Number of Sequences: 224733
Number of extensions: 2238217
Number of successful extensions: 6283
Number of sequences better than 10.0: 444
Number of HSP's better than 10.0 without gapping: 355
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 5115
Number of HSP's gapped (non-prelim): 540
length of query: 415
length of database: 73,234,838
effective HSP length: 92
effective length of query: 323
effective length of database: 52,559,402
effective search space: 16976686846
effective search space used: 16976686846
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 66 (30.7 bits)
- SilkBase 1999-2023 -