Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002197-TA|BGIBMGA002197-PA|IPR000719|Protein kinase,
IPR001054|Adenylyl cyclase class-3/4/guanylyl cyclase, IPR010916|TonB
box, N-terminal, IPR002290|Serine/threonine protein kinase,
IPR001245|Tyrosine protein kinase, IPR011009|Protein kinase-like
(1244 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q8IT60 Cluster: Guanylate cyclase; n=3; Coelomata|Rep: ... 1237 0.0
UniRef50_UPI0000D5787E Cluster: PREDICTED: similar to CG9783-PA;... 838 0.0
UniRef50_Q9VN32 Cluster: Guanylate cyclase; n=5; Diptera|Rep: Gu... 774 0.0
UniRef50_P51841 Cluster: Retinal guanylyl cyclase 2 precursor; n... 562 e-158
UniRef50_Q02846 Cluster: Retinal guanylyl cyclase 1 precursor; n... 557 e-157
UniRef50_A2BFQ0 Cluster: Guanylate cyclase; n=3; Danio rerio|Rep... 535 e-150
UniRef50_Q4SY29 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 530 e-149
UniRef50_A7SPS9 Cluster: Predicted protein; n=11; Eumetazoa|Rep:... 483 e-134
UniRef50_Q4TAT8 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 476 e-132
UniRef50_UPI00015B6146 Cluster: PREDICTED: similar to ENSANGP000... 470 e-130
UniRef50_P16065 Cluster: Speract receptor precursor; n=7; Euechi... 469 e-130
UniRef50_P16066 Cluster: Atrial natriuretic peptide receptor A p... 468 e-130
UniRef50_Q8IQK2 Cluster: Guanylate cyclase; n=6; Diptera|Rep: Gu... 468 e-130
UniRef50_Q8TA72 Cluster: Guanylate cyclase; n=2; Eumetazoa|Rep: ... 467 e-130
UniRef50_UPI00015B6145 Cluster: PREDICTED: similar to guanylate ... 461 e-128
UniRef50_O97053 Cluster: Guanylate cyclase; n=1; Stichopus japon... 457 e-127
UniRef50_UPI0000F2B0A8 Cluster: PREDICTED: similar to guanylyl c... 454 e-126
UniRef50_Q6TL19 Cluster: Guanylate cyclase 2G precursor; n=6; Mu... 453 e-125
UniRef50_UPI0000E45ED9 Cluster: PREDICTED: similar to ENSANGP000... 449 e-124
UniRef50_UPI00015B48AF Cluster: PREDICTED: similar to ENSANGP000... 447 e-124
UniRef50_Q9VF17 Cluster: Guanylate cyclase; n=7; Endopterygota|R... 447 e-123
UniRef50_Q17AF9 Cluster: Guanylate cyclase; n=1; Aedes aegypti|R... 446 e-123
UniRef50_UPI0000E4745B Cluster: PREDICTED: similar to ENSANGP000... 446 e-123
UniRef50_Q174S2 Cluster: Guanylate cyclase; n=7; Coelomata|Rep: ... 440 e-121
UniRef50_Q07553 Cluster: Guanylate cyclase 32E precursor; n=3; D... 437 e-120
UniRef50_UPI0000F1D453 Cluster: PREDICTED: similar to receptor t... 430 e-118
UniRef50_Q8T8L6 Cluster: Guanylate cyclase; n=5; Caenorhabditis|... 429 e-118
UniRef50_Q8MLX0 Cluster: CG3216-PB, isoform B; n=7; Endopterygot... 421 e-116
UniRef50_UPI0000E46159 Cluster: PREDICTED: similar to natriureti... 418 e-115
UniRef50_Q6UCJ4 Cluster: Guanylate cyclase PcGC-M2 precursor; n=... 415 e-114
UniRef50_A7SJA1 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 414 e-114
UniRef50_O01779 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 405 e-111
UniRef50_UPI0000E4627A Cluster: PREDICTED: similar to membrane g... 404 e-111
UniRef50_A7RUA8 Cluster: Predicted protein; n=1; Nematostella ve... 403 e-110
UniRef50_Q9XTY1 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 402 e-110
UniRef50_Q19187 Cluster: Guanylate cyclase; n=3; Bilateria|Rep: ... 398 e-109
UniRef50_Q23310 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 396 e-108
UniRef50_Q4SW10 Cluster: Guanylate cyclase; n=4; Tetraodontidae|... 394 e-108
UniRef50_Q7JP51 Cluster: Guanylate cyclase; n=6; Caenorhabditis|... 392 e-107
UniRef50_Q75V80 Cluster: Guanylate cyclase; n=11; Euteleostomi|R... 392 e-107
UniRef50_Q18331 Cluster: Guanylyl cyclase protein 11; n=2; Caeno... 390 e-107
UniRef50_O16715 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 382 e-104
UniRef50_Q4RYJ0 Cluster: Guanylate cyclase; n=2; Tetraodontidae|... 381 e-104
UniRef50_O96993 Cluster: Guanylate cyclase; n=1; Heterodera glyc... 380 e-103
UniRef50_Q9GT36 Cluster: Guanylate cyclase; n=1; Heterodera glyc... 378 e-103
UniRef50_Q09435 Cluster: Guanylate cyclase receptor-type gcy-1 p... 375 e-102
UniRef50_Q4T7P7 Cluster: Chromosome undetermined SCAF8055, whole... 373 e-101
UniRef50_Q19768 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 372 e-101
UniRef50_P25092 Cluster: Heat-stable enterotoxin receptor precur... 368 e-100
UniRef50_Q9XVV4 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 360 2e-97
UniRef50_Q10029 Cluster: Guanylate cyclase; n=1; Caenorhabditis ... 359 2e-97
UniRef50_O16544 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 353 2e-95
UniRef50_Q2L6K6 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 322 3e-86
UniRef50_Q2L6K5 Cluster: Guanylate cyclase; n=3; Caenorhabditis|... 322 3e-86
UniRef50_Q2L6K7 Cluster: Recepotor type guanyly cyclase; n=1; Ca... 315 6e-84
UniRef50_UPI000065CD57 Cluster: Heat-stable enterotoxin receptor... 314 1e-83
UniRef50_Q9GYQ4 Cluster: Guanylyl cyclase protein 8; n=3; Caenor... 312 5e-83
UniRef50_Q9GT37 Cluster: Guanylate cyclase; n=2; Heterodera glyc... 305 5e-81
UniRef50_Q90WX1 Cluster: Guanylyl cyclase 2; n=7; Eumetazoa|Rep:... 303 1e-80
UniRef50_O62026 Cluster: Putative uncharacterized protein gcy-29... 300 1e-79
UniRef50_Q23496 Cluster: Guanylate cyclase; n=2; Caenorhabditis|... 297 2e-78
UniRef50_O77149 Cluster: NO-insensitive guanylyl cyclase; n=1; M... 289 2e-76
UniRef50_Q9U317 Cluster: Putative uncharacterized protein gcy-25... 282 5e-74
UniRef50_Q5SR07 Cluster: Natriuretic peptide receptor A/guanylat... 278 8e-73
UniRef50_UPI0000F1EB17 Cluster: PREDICTED: similar to ENSANGP000... 262 4e-68
UniRef50_Q9NGZ8 Cluster: Guanylyl cyclase; n=4; Caenorhabditis|R... 261 1e-67
UniRef50_UPI0000E47581 Cluster: PREDICTED: similar to natriureti... 260 2e-67
UniRef50_Q17BS6 Cluster: Guanylate cyclase; n=2; Culicidae|Rep: ... 249 4e-64
UniRef50_Q7YXG2 Cluster: Soluble guanylyl cyclase 1 beta; n=1; L... 237 1e-60
UniRef50_Q1EC29 Cluster: IP04501p; n=7; Endopterygota|Rep: IP045... 236 2e-60
UniRef50_A7RZH8 Cluster: Predicted protein; n=1; Nematostella ve... 236 2e-60
UniRef50_Q8I4N4 Cluster: Putative uncharacterized protein daf-11... 234 1e-59
UniRef50_UPI0000586706 Cluster: PREDICTED: similar to guanylate ... 234 1e-59
UniRef50_A7RU15 Cluster: Predicted protein; n=1; Nematostella ve... 231 7e-59
UniRef50_UPI0000586B0F Cluster: PREDICTED: similar to receptor t... 230 2e-58
UniRef50_Q7YXG1 Cluster: Soluble guanylyl cyclase 2 beta; n=1; L... 229 4e-58
UniRef50_UPI0000E49095 Cluster: PREDICTED: similar to guanylate ... 229 5e-58
UniRef50_UPI0000E48651 Cluster: PREDICTED: similar to membrane g... 228 8e-58
UniRef50_UPI0000E4A009 Cluster: PREDICTED: similar to soluble gu... 221 1e-55
UniRef50_UPI00006975C6 Cluster: Guanylyl CYclase family member (... 219 3e-55
UniRef50_A6NJF2 Cluster: Uncharacterized protein NPR2; n=19; Eut... 217 2e-54
UniRef50_UPI0000ECB130 Cluster: Guanylate cyclase soluble subuni... 216 3e-54
UniRef50_Q8INF0 Cluster: Soluble guanylate cyclase 88E; n=12; Co... 211 1e-52
UniRef50_Q16JH8 Cluster: Soluble guanylate cyclase gcy; n=2; Cul... 209 3e-52
UniRef50_O02298 Cluster: Soluble guanylate cyclase gcy-35; n=2; ... 206 3e-51
UniRef50_O75343 Cluster: Guanylate cyclase soluble subunit beta-... 205 5e-51
UniRef50_Q9EXQ2 Cluster: Adenylate cyclase; n=3; Oscillatoriales... 204 9e-51
UniRef50_A7RY93 Cluster: Predicted protein; n=2; Nematostella ve... 197 1e-48
UniRef50_Q4T7S3 Cluster: Guanylate cyclase; n=1; Tetraodon nigro... 195 7e-48
UniRef50_Q5YLC2 Cluster: Soluble guanylyl cyclase beta; n=1; Chl... 193 2e-47
UniRef50_A0YIQ8 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 193 3e-47
UniRef50_A0YN57 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 192 4e-47
UniRef50_A7BXS6 Cluster: Adenylate/guanylate cyclase; n=1; Beggi... 188 6e-46
UniRef50_A0YPF4 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 186 3e-45
UniRef50_A0YSC8 Cluster: Extracellular ligand-binding receptor; ... 186 3e-45
UniRef50_UPI00005841ED Cluster: PREDICTED: similar to soluble gu... 186 4e-45
UniRef50_UPI00015B5A8E Cluster: PREDICTED: similar to ENSANGP000... 185 8e-45
UniRef50_P92006 Cluster: Soluble guanylate cyclase gcy-34; n=7; ... 184 2e-44
UniRef50_A0YU66 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 183 3e-44
UniRef50_Q4S4C7 Cluster: Chromosome 2 SCAF14738, whole genome sh... 182 7e-44
UniRef50_A0YS29 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 182 7e-44
UniRef50_UPI000038D385 Cluster: COG2114: Adenylate cyclase, fami... 179 4e-43
UniRef50_A7RN72 Cluster: Predicted protein; n=1; Nematostella ve... 179 5e-43
UniRef50_Q9VEU5 Cluster: Soluble guanylate cyclase 89Db; n=6; Di... 179 5e-43
UniRef50_P33402 Cluster: Guanylate cyclase soluble subunit alpha... 176 4e-42
UniRef50_UPI00015B5C60 Cluster: PREDICTED: similar to soluble gu... 175 5e-42
UniRef50_Q8YZ26 Cluster: Adenylate cyclase; n=1; Nostoc sp. PCC ... 175 5e-42
UniRef50_Q9VA09 Cluster: CG1470-PA; n=6; Diptera|Rep: CG1470-PA ... 175 8e-42
UniRef50_Q9ERL9 Cluster: Guanylate cyclase soluble subunit alpha... 175 8e-42
UniRef50_Q7Q9W6 Cluster: ENSANGP00000003998; n=1; Anopheles gamb... 174 1e-41
UniRef50_Q02108 Cluster: Guanylate cyclase soluble subunit alpha... 173 2e-41
UniRef50_Q7ZSZ5 Cluster: Soluble guanylyl cyclase alpha2 subunit... 172 4e-41
UniRef50_Q86C56 Cluster: Soluble guanylate cyclase gcy-31; n=4; ... 172 6e-41
UniRef50_Q10XK8 Cluster: Adenylate/guanylate cyclase precursor; ... 171 1e-40
UniRef50_Q07093 Cluster: Head-specific guanylate cyclase; n=8; E... 167 2e-39
UniRef50_Q02153 Cluster: Guanylate cyclase soluble subunit beta-... 166 3e-39
UniRef50_Q8F690 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:... 164 1e-38
UniRef50_A5P0P3 Cluster: Response regulator receiver protein; n=... 164 2e-38
UniRef50_A0YQ82 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC... 164 2e-38
UniRef50_Q7YWK7 Cluster: Soluble guanylate cyclase subunit; n=1;... 164 2e-38
UniRef50_P0A4Y1 Cluster: Adenylate cyclase; n=15; Mycobacterium|... 164 2e-38
UniRef50_Q4TB76 Cluster: Chromosome undetermined SCAF7184, whole... 163 4e-38
UniRef50_Q1H0Z8 Cluster: Adenylate/guanylate cyclase; n=1; Methy... 161 1e-37
UniRef50_P90895 Cluster: Soluble guanylate cyclase gcy-33; n=2; ... 161 1e-37
UniRef50_Q1NSQ3 Cluster: Adenylate cyclase; n=1; delta proteobac... 161 1e-37
UniRef50_A7S7B2 Cluster: Predicted protein; n=1; Nematostella ve... 161 1e-37
UniRef50_A1ZSW5 Cluster: Adenylate cyclase; n=1; Microscilla mar... 160 3e-37
UniRef50_Q89SW2 Cluster: Two-component hybrid sensor and regulat... 159 4e-37
UniRef50_Q95NK5 Cluster: Soluble guanylyl cyclase beta1; n=2; St... 159 6e-37
UniRef50_Q9XZS0 Cluster: Guanylyl cyclase; n=4; cellular organis... 158 8e-37
UniRef50_Q5UFR4 Cluster: Cya1625; n=1; Mycobacterium smegmatis|R... 158 1e-36
UniRef50_Q4T0M0 Cluster: Guanylate cyclase; n=1; Tetraodon nigro... 154 1e-35
UniRef50_A1ZSW4 Cluster: Atrial natriuretic peptide receptor A; ... 154 1e-35
UniRef50_UPI0000E490E0 Cluster: PREDICTED: similar to guanylate ... 154 2e-35
UniRef50_Q394B3 Cluster: Adenylate/guanylate cyclase; n=4; Burkh... 153 2e-35
UniRef50_Q92WJ5 Cluster: Putative regulatory protein; n=2; Sinor... 153 3e-35
UniRef50_A7RN69 Cluster: Predicted protein; n=2; Nematostella ve... 153 3e-35
UniRef50_A7C2F8 Cluster: Rh-like protein/ammonium transporter; n... 152 7e-35
UniRef50_Q47AI8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 151 9e-35
UniRef50_UPI0000DB7371 Cluster: PREDICTED: similar to Guanylyl c... 150 2e-34
UniRef50_Q28S34 Cluster: Adenylate/guanylate cyclase; n=1; Janna... 149 5e-34
UniRef50_A7S7B3 Cluster: Predicted protein; n=1; Nematostella ve... 149 6e-34
UniRef50_Q7WWV9 Cluster: Putative regulatory protein; n=1; Ralst... 148 1e-33
UniRef50_A7RN70 Cluster: Predicted protein; n=1; Nematostella ve... 147 2e-33
UniRef50_A4AWH6 Cluster: Adenylate/guanylate cyclase; n=1; Flavo... 145 8e-33
UniRef50_A6PTF8 Cluster: Putative adenylate/guanylate cyclase; n... 144 1e-32
UniRef50_A1ZW48 Cluster: Adenylate cyclase; n=1; Microscilla mar... 142 5e-32
UniRef50_Q98GN7 Cluster: Cyclase; n=1; Mesorhizobium loti|Rep: C... 141 1e-31
UniRef50_Q73RD3 Cluster: Adenylate/guanylate cyclase catalytic d... 140 2e-31
UniRef50_Q0LMK3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 140 2e-31
UniRef50_A1ZXW2 Cluster: Adenylate cyclase; n=1; Microscilla mar... 140 2e-31
UniRef50_A1ZQH6 Cluster: Heat-stable enterotoxin receptor; n=1; ... 140 2e-31
UniRef50_A6FX69 Cluster: Adenylate or guanylate cyclase; n=1; Pl... 138 7e-31
UniRef50_Q8F1T7 Cluster: Adenylate cyclase; n=2; Leptospira inte... 138 9e-31
UniRef50_A1ZVN3 Cluster: Adenylate or guanylate cyclase; n=1; Mi... 138 1e-30
UniRef50_Q15T90 Cluster: Adenylate/guanylate cyclase; n=1; Pseud... 136 5e-30
UniRef50_A3I1K5 Cluster: Adenylate/guanylate cyclase; n=1; Algor... 136 5e-30
UniRef50_A1ZJP1 Cluster: Adenylate cyclase; n=1; Microscilla mar... 134 2e-29
UniRef50_Q6DNF3 Cluster: Soluble guanylate cyclase gcy-37; n=2; ... 132 4e-29
UniRef50_Q8F778 Cluster: Adenylate cyclase; n=3; Leptospira inte... 132 8e-29
UniRef50_A1ZFP4 Cluster: Two-component hybrid sensor and regulat... 131 1e-28
UniRef50_A7RRQ7 Cluster: Predicted protein; n=1; Nematostella ve... 128 7e-28
UniRef50_UPI0000F1FEB6 Cluster: PREDICTED: similar to solble gua... 128 1e-27
UniRef50_A0LXB4 Cluster: Secreted protein containing adenylate/g... 127 2e-27
UniRef50_Q1NWK5 Cluster: Guanylate cyclase; n=2; delta proteobac... 126 3e-27
UniRef50_A3HVA1 Cluster: Adenylate/guanylate cyclase; n=1; Algor... 126 4e-27
UniRef50_O95622 Cluster: Adenylate cyclase type 5; n=41; Deutero... 126 4e-27
UniRef50_A5P476 Cluster: Putative adenylate/guanylate cyclase; n... 125 7e-27
UniRef50_Q4RZ92 Cluster: Chromosome 1 SCAF14944, whole genome sh... 125 9e-27
UniRef50_A3HV63 Cluster: Adenylate or guanylate cyclase; n=1; Al... 124 1e-26
UniRef50_Q4RVX9 Cluster: Chromosome 9 SCAF14991, whole genome sh... 123 4e-26
UniRef50_Q03101 Cluster: Adenylate cyclase, germination specific... 123 4e-26
UniRef50_Q5MAL1 Cluster: Adenylate cyclase; n=1; Aplysia califor... 121 1e-25
UniRef50_Q238W6 Cluster: Adenylate and Guanylate cyclase catalyt... 121 1e-25
UniRef50_A2DDF2 Cluster: Adenylate and Guanylate cyclase catalyt... 121 1e-25
UniRef50_UPI0000DB7A4D Cluster: PREDICTED: similar to Adenylyl c... 120 2e-25
UniRef50_A2EQT4 Cluster: Adenylate and Guanylate cyclase catalyt... 120 2e-25
UniRef50_A2EN44 Cluster: Adenylate and Guanylate cyclase catalyt... 120 2e-25
UniRef50_UPI000069F10A Cluster: Adenylate cyclase type 6 (EC 4.6... 118 8e-25
UniRef50_A2DXM9 Cluster: Adenylate and Guanylate cyclase catalyt... 118 1e-24
UniRef50_UPI0000D5745B Cluster: PREDICTED: similar to CG32158-PB... 117 2e-24
UniRef50_A2DJ96 Cluster: Adenylate and Guanylate cyclase catalyt... 117 2e-24
UniRef50_UPI00006CB402 Cluster: Adenylate and Guanylate cyclase ... 117 2e-24
UniRef50_A3WBP2 Cluster: Adenylate/guanylate cyclase; n=1; Eryth... 117 2e-24
UniRef50_A2DY07 Cluster: Adenylate and Guanylate cyclase catalyt... 117 2e-24
UniRef50_Q16W55 Cluster: Adenylate cyclase; n=1; Aedes aegypti|R... 116 3e-24
UniRef50_A0EAN1 Cluster: Chromosome undetermined scaffold_86, wh... 116 3e-24
UniRef50_A0EHP6 Cluster: Cation-transporting ATPase; n=3; Parame... 116 4e-24
UniRef50_UPI00005A2FB4 Cluster: PREDICTED: similar to brain aden... 115 7e-24
UniRef50_A2FAE9 Cluster: Adenylate and Guanylate cyclase catalyt... 115 7e-24
UniRef50_Q4SUW5 Cluster: Chromosome undetermined SCAF13838, whol... 115 9e-24
UniRef50_A2FLP2 Cluster: Adenylate and Guanylate cyclase catalyt... 115 9e-24
UniRef50_A0BPN4 Cluster: Chromosome undetermined scaffold_12, wh... 115 9e-24
UniRef50_O60503 Cluster: Adenylate cyclase type 9; n=29; Euteleo... 115 9e-24
UniRef50_Q966F9 Cluster: Adenylyl cyclase protein 4; n=2; Caenor... 114 1e-23
UniRef50_Q9VV68 Cluster: CG32158-PB, isoform B; n=12; Coelomata|... 114 2e-23
UniRef50_A0CEN0 Cluster: Chromosome undetermined scaffold_172, w... 114 2e-23
UniRef50_P32870 Cluster: Ca(2+)/calmodulin-responsive adenylate ... 114 2e-23
UniRef50_A2E4D6 Cluster: Adenylate and Guanylate cyclase catalyt... 113 2e-23
UniRef50_A0P034 Cluster: Adenylate cyclase; n=1; Stappia aggrega... 113 3e-23
UniRef50_A0E8U0 Cluster: Cation-transporting ATPase; n=4; Parame... 113 3e-23
UniRef50_Q54H45 Cluster: Protein kinase, TKL group; n=1; Dictyos... 113 4e-23
UniRef50_Q1MU16 Cluster: ORF for hypothetical protein; n=2; Apoc... 113 4e-23
UniRef50_A7AX98 Cluster: Adenylate and guanylate cyclase catalyt... 113 4e-23
UniRef50_A2DLQ6 Cluster: Adenylate and Guanylate cyclase catalyt... 113 4e-23
UniRef50_Q08828 Cluster: Adenylate cyclase type 1 (EC 4.6.1.1) (... 113 4e-23
UniRef50_UPI000069E679 Cluster: Adenylate cyclase type 1 (EC 4.6... 112 5e-23
UniRef50_A0C5P9 Cluster: Chromosome undetermined scaffold_150, w... 112 5e-23
UniRef50_UPI00015B5E7D Cluster: PREDICTED: similar to adenylate ... 112 7e-23
UniRef50_UPI0000D56082 Cluster: PREDICTED: similar to adenylate ... 112 7e-23
UniRef50_Q5MAL2 Cluster: Adenylate cyclase; n=1; Aplysia califor... 112 7e-23
UniRef50_A2DC46 Cluster: Adenylate and Guanylate cyclase catalyt... 112 7e-23
UniRef50_UPI0000D55CA0 Cluster: PREDICTED: similar to CG9210-PA,... 111 9e-23
UniRef50_Q1VN94 Cluster: Two-component hybrid sensor and regulat... 111 9e-23
UniRef50_O96306 Cluster: Adenylyl cyclase isoform DAC39E; n=7; D... 111 9e-23
UniRef50_A2FSM3 Cluster: Adenylate and Guanylate cyclase catalyt... 111 9e-23
UniRef50_A0C5Y1 Cluster: Chromosome undetermined scaffold_151, w... 111 9e-23
UniRef50_A2FW09 Cluster: Adenylate and Guanylate cyclase catalyt... 111 2e-22
UniRef50_A2FG49 Cluster: Adenylate and Guanylate cyclase catalyt... 111 2e-22
UniRef50_A2DFE4 Cluster: Adenylate and Guanylate cyclase catalyt... 111 2e-22
UniRef50_UPI0000D56083 Cluster: PREDICTED: similar to CG10564-PA... 110 2e-22
UniRef50_Q23TD7 Cluster: Adenylate and Guanylate cyclase catalyt... 110 3e-22
UniRef50_UPI00006CFA91 Cluster: Adenylate and Guanylate cyclase ... 109 4e-22
UniRef50_A2F3K7 Cluster: Adenylate and Guanylate cyclase catalyt... 109 4e-22
UniRef50_Q4STI6 Cluster: Chromosome undetermined SCAF14199, whol... 109 5e-22
UniRef50_A2GA06 Cluster: Adenylate and Guanylate cyclase catalyt... 109 5e-22
UniRef50_A2EII5 Cluster: Adenylate and Guanylate cyclase catalyt... 109 5e-22
UniRef50_A0CKZ5 Cluster: Chromosome undetermined scaffold_20, wh... 109 5e-22
UniRef50_A0C7P7 Cluster: Chromosome undetermined scaffold_156, w... 109 5e-22
UniRef50_Q19523 Cluster: Putative uncharacterized protein acy-1;... 109 6e-22
UniRef50_Q0C7B2 Cluster: Adenylate cyclase; n=2; Culicidae|Rep: ... 109 6e-22
UniRef50_Q54H46 Cluster: Protein kinase, TKL group; n=1; Dictyos... 108 8e-22
UniRef50_UPI00006CB3C2 Cluster: Adenylate and Guanylate cyclase ... 108 1e-21
UniRef50_UPI000069E67B Cluster: Adenylate cyclase type 1 (EC 4.6... 108 1e-21
UniRef50_Q5TUN5 Cluster: ENSANGP00000027378; n=2; Culicidae|Rep:... 108 1e-21
UniRef50_A2F2E6 Cluster: Adenylate and Guanylate cyclase catalyt... 108 1e-21
UniRef50_A2EN10 Cluster: Adenylate and Guanylate cyclase catalyt... 108 1e-21
UniRef50_A2E7P5 Cluster: Adenylate and Guanylate cyclase catalyt... 108 1e-21
UniRef50_Q5MAL0 Cluster: Adenylate cyclase; n=2; Eukaryota|Rep: ... 107 1e-21
UniRef50_A7SS39 Cluster: Predicted protein; n=1; Nematostella ve... 107 1e-21
UniRef50_Q8NFM4 Cluster: Adenylate cyclase type 4; n=73; Euteleo... 107 1e-21
UniRef50_Q4RR06 Cluster: Chromosome 14 SCAF15003, whole genome s... 107 2e-21
UniRef50_Q23DS0 Cluster: Adenylate and Guanylate cyclase catalyt... 107 2e-21
UniRef50_UPI0000DB73AC Cluster: PREDICTED: similar to Adenylyl c... 106 3e-21
UniRef50_Q231I7 Cluster: Adenylate and Guanylate cyclase catalyt... 106 3e-21
UniRef50_A0CQM4 Cluster: Chromosome undetermined scaffold_24, wh... 106 3e-21
UniRef50_Q6BG52 Cluster: Guanylyl cyclase, putative; n=4; Parame... 106 4e-21
UniRef50_O16880 Cluster: Adenylyl cyclase protein 2; n=2; Caenor... 106 4e-21
UniRef50_A0D3H6 Cluster: Chromosome undetermined scaffold_36, wh... 106 4e-21
UniRef50_Q4RZV3 Cluster: Chromosome 18 SCAF14786, whole genome s... 105 6e-21
UniRef50_A5NV94 Cluster: Response regulator receiver protein; n=... 105 6e-21
UniRef50_A7RN58 Cluster: Predicted protein; n=2; Nematostella ve... 105 6e-21
UniRef50_A2FWD6 Cluster: Adenylate and Guanylate cyclase catalyt... 105 6e-21
UniRef50_UPI0000DB755E Cluster: PREDICTED: similar to Adenylyl c... 105 8e-21
UniRef50_Q6PG12 Cluster: Adcy3 protein; n=13; Euteleostomi|Rep: ... 105 8e-21
UniRef50_O60266 Cluster: Adenylate cyclase type 3; n=21; Theria|... 105 8e-21
UniRef50_Q4T405 Cluster: Chromosome 8 SCAF9864, whole genome sho... 105 1e-20
UniRef50_A0DVQ1 Cluster: Chromosome undetermined scaffold_66, wh... 105 1e-20
UniRef50_A0BG69 Cluster: Chromosome undetermined scaffold_105, w... 105 1e-20
UniRef50_Q7QEP6 Cluster: ENSANGP00000019838; n=3; Bilateria|Rep:... 104 1e-20
UniRef50_A2ECV6 Cluster: Adenylate and Guanylate cyclase catalyt... 104 1e-20
UniRef50_UPI0000E47CE1 Cluster: PREDICTED: similar to Adenylate ... 104 2e-20
UniRef50_Q9N9H5 Cluster: Guanylyl cyclase; n=3; Plasmodium falci... 103 2e-20
UniRef50_Q54TM7 Cluster: Leucine-rich repeat-containing protein;... 103 2e-20
UniRef50_UPI00015AE44D Cluster: hypothetical protein NEMVEDRAFT_... 103 3e-20
UniRef50_Q7QDV4 Cluster: ENSANGP00000010056; n=1; Anopheles gamb... 103 3e-20
UniRef50_Q4UFI5 Cluster: Cation-transporting ATPase; n=1; Theile... 103 3e-20
UniRef50_Q4N3Z0 Cluster: Cation-transporting ATPase; n=1; Theile... 102 5e-20
UniRef50_O16039 Cluster: Adenylyl cyclase isoform DAC9; n=4; Sop... 102 5e-20
UniRef50_A2FB45 Cluster: Adenylate and Guanylate cyclase catalyt... 102 7e-20
UniRef50_P40145 Cluster: Adenylate cyclase type 8 (EC 4.6.1.1) (... 102 7e-20
UniRef50_UPI00015B5520 Cluster: PREDICTED: similar to adenylate ... 101 9e-20
UniRef50_UPI00006CF863 Cluster: Adenylate and Guanylate cyclase ... 101 9e-20
UniRef50_UPI000065F95C Cluster: Homolog of Oryzias latipes "Solu... 101 9e-20
UniRef50_A5K544 Cluster: Adenylate and Guanylate cyclase catalyt... 101 9e-20
UniRef50_UPI00006D0DB9 Cluster: Sodium/calcium exchanger protein... 101 1e-19
UniRef50_A2G2M4 Cluster: Adenylate and Guanylate cyclase catalyt... 101 1e-19
UniRef50_A2DWV8 Cluster: Adenylate and Guanylate cyclase catalyt... 101 1e-19
UniRef50_A0DTD8 Cluster: Chromosome undetermined scaffold_63, wh... 101 1e-19
UniRef50_Q54TA1 Cluster: E set domain-containing protein; n=1; D... 101 2e-19
UniRef50_Q17010 Cluster: Soluble guanylate cyclase; n=14; Cellia... 101 2e-19
UniRef50_UPI00015A564B Cluster: Novel protein similar to vertebr... 100 2e-19
UniRef50_Q9U928 Cluster: Guanylyl cyclase; n=2; Tetrahymena pyri... 100 2e-19
UniRef50_A7S0C5 Cluster: Predicted protein; n=1; Nematostella ve... 100 2e-19
UniRef50_A2FID0 Cluster: Adenylate and Guanylate cyclase catalyt... 100 2e-19
UniRef50_Q16XH3 Cluster: Adenylate cyclase; n=3; Endopterygota|R... 100 3e-19
UniRef50_A2F3J3 Cluster: Adenylate and Guanylate cyclase catalyt... 100 3e-19
UniRef50_UPI000155DD86 Cluster: PREDICTED: similar to adenylate ... 99 4e-19
UniRef50_UPI0000DD80AC Cluster: PREDICTED: similar to Olfactory ... 99 4e-19
UniRef50_Q9GVB8 Cluster: Guanylyl cyclase enzyme; n=3; Plasmodiu... 99 4e-19
UniRef50_UPI00015A6AA9 Cluster: Adenylate cyclase type 8 (EC 4.6... 100 5e-19
UniRef50_Q4SNI3 Cluster: Chromosome 15 SCAF14542, whole genome s... 100 5e-19
UniRef50_Q8IGU9 Cluster: RE26442p; n=4; Sophophora|Rep: RE26442p... 100 5e-19
UniRef50_UPI0000DB7252 Cluster: PREDICTED: similar to ACXD CG571... 99 7e-19
UniRef50_Q4T7J2 Cluster: Chromosome undetermined SCAF8089, whole... 99 7e-19
UniRef50_Q22AU0 Cluster: Adenylate and Guanylate cyclase catalyt... 99 7e-19
UniRef50_A2FZG6 Cluster: Adenylate and Guanylate cyclase catalyt... 99 7e-19
UniRef50_A2EEV5 Cluster: Adenylate and Guanylate cyclase catalyt... 99 7e-19
UniRef50_UPI000065E155 Cluster: Adenylate cyclase type 8 (EC 4.6... 99 9e-19
UniRef50_UPI00006CEB6E Cluster: Adenylate and Guanylate cyclase ... 98 1e-18
UniRef50_A2FPM7 Cluster: Adenylate and Guanylate cyclase catalyt... 98 1e-18
UniRef50_A2DTD4 Cluster: Adenylate and Guanylate cyclase catalyt... 98 2e-18
UniRef50_Q9VW60 Cluster: Adenylate cyclase type 2; n=2; Sophopho... 98 2e-18
UniRef50_Q4BYX5 Cluster: Guanylate cyclase:Histidine kinase, HAM... 97 2e-18
UniRef50_Q9Y1V0 Cluster: Adenylyl cyclase 78C-L; n=4; Sophophora... 97 2e-18
UniRef50_Q17AS9 Cluster: Adenylate cyclase; n=2; Culicidae|Rep: ... 97 2e-18
UniRef50_UPI00015B5F6F Cluster: PREDICTED: similar to ENSANGP000... 97 3e-18
UniRef50_UPI0000E49494 Cluster: PREDICTED: similar to adenylyl c... 97 3e-18
UniRef50_A2DBX9 Cluster: Adenylate and Guanylate cyclase catalyt... 97 3e-18
UniRef50_UPI00004986C0 Cluster: protein kinase; n=1; Entamoeba h... 97 4e-18
UniRef50_A0MJN0 Cluster: Guanylate cyclase beta; n=11; Plasmodiu... 96 5e-18
UniRef50_Q8IRF5 Cluster: CG32305-PA; n=2; Sophophora|Rep: CG3230... 95 8e-18
UniRef50_A6PCE2 Cluster: Putative adenylate/guanylate cyclase pr... 95 1e-17
UniRef50_Q4Z354 Cluster: Guanylyl cyclase, putative; n=8; Plasmo... 95 1e-17
UniRef50_A2EII6 Cluster: Adenylate and Guanylate cyclase catalyt... 95 1e-17
UniRef50_A3YYJ3 Cluster: Putative uncharacterized protein; n=1; ... 95 1e-17
UniRef50_A2GB93 Cluster: Adenylate and Guanylate cyclase catalyt... 95 1e-17
UniRef50_A2ES71 Cluster: Adenylate and Guanylate cyclase catalyt... 95 1e-17
UniRef50_A2DKP6 Cluster: Adenylate and Guanylate cyclase catalyt... 95 1e-17
UniRef50_A0Y7P2 Cluster: Adenylate/guanylate cyclase; n=1; marin... 94 2e-17
UniRef50_A0NLS4 Cluster: Adenylate cyclase 1; n=1; Stappia aggre... 94 2e-17
UniRef50_Q7T6X2 Cluster: Putative serine/threonine-protein kinas... 94 2e-17
UniRef50_Q6WIQ8 Cluster: Adenylate cyclase type VII; n=2; Xenopu... 93 3e-17
UniRef50_Q6MNW4 Cluster: Adenylate cyclase precursor; n=1; Bdell... 93 3e-17
UniRef50_Q9VK53 Cluster: CG5983-PA, isoform A; n=13; Sophophora|... 93 4e-17
UniRef50_Q4S9A3 Cluster: Chromosome undetermined SCAF14699, whol... 93 6e-17
UniRef50_UPI000155CC3E Cluster: PREDICTED: similar to adenylate ... 92 8e-17
UniRef50_A7NLF3 Cluster: Adenylate/guanylate cyclase with GAF se... 92 8e-17
UniRef50_Q9W037 Cluster: CG32301-PA; n=1; Drosophila melanogaste... 92 8e-17
UniRef50_A2FKW6 Cluster: Adenylate and Guanylate cyclase catalyt... 92 8e-17
UniRef50_Q4SW38 Cluster: Chromosome undetermined SCAF13692, whol... 91 2e-16
UniRef50_A7QKI2 Cluster: Chromosome chr2 scaffold_112, whole gen... 91 2e-16
UniRef50_Q8LPH3 Cluster: MAP kinase, putative; n=8; Brassicaceae... 90 3e-16
UniRef50_Q1SMZ9 Cluster: Protein kinase; n=3; Viridiplantae|Rep:... 90 3e-16
UniRef50_UPI00006CB738 Cluster: Adenylate and Guanylate cyclase ... 90 4e-16
UniRef50_A0P2D1 Cluster: Adenylate cyclase 1 protein; n=2; Stapp... 90 4e-16
UniRef50_UPI000049A3B4 Cluster: protein kinase; n=1; Entamoeba h... 89 5e-16
UniRef50_Q1YML1 Cluster: Putative adenylate/guanylate cyclase wi... 89 9e-16
UniRef50_UPI000065D458 Cluster: Adenylate cyclase type 3 (EC 4.6... 88 1e-15
UniRef50_Q9FGZ6 Cluster: Protein kinase; n=3; Arabidopsis thalia... 88 2e-15
UniRef50_Q9C833 Cluster: Protein kinase, putative; 42705-46677; ... 88 2e-15
UniRef50_Q8MZE0 Cluster: AT09365p; n=1; Drosophila melanogaster|... 88 2e-15
UniRef50_Q7T6Y2 Cluster: Putative serine/threonine-protein kinas... 88 2e-15
UniRef50_UPI0000498D53 Cluster: protein kinase; n=1; Entamoeba h... 87 2e-15
UniRef50_Q2LQ30 Cluster: HD domain protein; n=1; Syntrophus acid... 87 2e-15
UniRef50_Q08NP4 Cluster: Adenylate cyclase 1; n=2; Cystobacterin... 87 2e-15
UniRef50_Q1MJZ0 Cluster: Putative adenylate/guanylate cyclase; n... 87 4e-15
UniRef50_Q0DDD4 Cluster: Os06g0232100 protein; n=5; Oryza sativa... 86 5e-15
UniRef50_A2YAZ9 Cluster: Putative uncharacterized protein; n=1; ... 86 5e-15
UniRef50_Q6E6T5 Cluster: L3i88 isoform b; n=5; Dictyocaulus vivi... 86 5e-15
UniRef50_A7PH50 Cluster: Chromosome chr17 scaffold_16, whole gen... 86 7e-15
UniRef50_A2D8T2 Cluster: Adenylate and Guanylate cyclase catalyt... 86 7e-15
UniRef50_A0C299 Cluster: Chromosome undetermined scaffold_144, w... 86 7e-15
UniRef50_A0QDI3 Cluster: Adenylate and Guanylate cyclase catalyt... 85 9e-15
UniRef50_O82754 Cluster: Putative serine/threonine kinase; n=2; ... 85 9e-15
UniRef50_A7P4M8 Cluster: Chromosome chr4 scaffold_6, whole genom... 85 9e-15
UniRef50_Q5YKK5 Cluster: CTR1-like protein kinase; n=12; core eu... 85 1e-14
UniRef50_Q5XPL8 Cluster: EDR1; n=5; BEP clade|Rep: EDR1 - Tritic... 85 1e-14
UniRef50_Q1DD79 Cluster: Adenylate/guanylate cyclase domain prot... 85 2e-14
UniRef50_Q9FPR5 Cluster: EDR1; n=6; Magnoliophyta|Rep: EDR1 - Or... 85 2e-14
UniRef50_Q7A2H3 Cluster: Adenylate cyclase; n=5; Nostocaceae|Rep... 84 2e-14
UniRef50_Q96KY6 Cluster: ADCY4 protein; n=20; Euteleostomi|Rep: ... 84 2e-14
UniRef50_UPI000038C573 Cluster: COG2114: Adenylate cyclase, fami... 84 3e-14
UniRef50_A7QS17 Cluster: Chromosome undetermined scaffold_155, w... 83 4e-14
UniRef50_A5AQH5 Cluster: Putative uncharacterized protein; n=1; ... 83 4e-14
UniRef50_Q55AN7 Cluster: SMAD/FHA domain-containing protein; n=2... 83 4e-14
UniRef50_Q03100 Cluster: Adenylate cyclase, aggregation specific... 83 4e-14
UniRef50_Q05609 Cluster: Serine/threonine-protein kinase CTR1; n... 83 4e-14
UniRef50_Q0EZ20 Cluster: Adenylate/Guanylate Cyclase; n=1; Marip... 83 5e-14
UniRef50_A6LJV0 Cluster: Putative adenylate/guanylate cyclase; n... 83 5e-14
UniRef50_Q9STU7 Cluster: Putative uncharacterized protein T22A6.... 83 5e-14
UniRef50_Q54QQ1 Cluster: Protein serine/threonine kinase; n=2; D... 83 5e-14
UniRef50_P40137 Cluster: Adenylate cyclase 1; n=2; Stigmatella a... 83 5e-14
UniRef50_A1WY91 Cluster: Putative adenylate/guanylate cyclase pr... 83 6e-14
UniRef50_A2DJR4 Cluster: Adenylate and Guanylate cyclase catalyt... 82 8e-14
UniRef50_A0D9Q7 Cluster: Chromosome undetermined scaffold_42, wh... 82 8e-14
UniRef50_A7BYP4 Cluster: Guanylyl cyclase; n=1; Beggiatoa sp. PS... 82 1e-13
UniRef50_Q9FRR5 Cluster: F22O13.20; n=37; Eukaryota|Rep: F22O13.... 82 1e-13
UniRef50_Q9C547 Cluster: Protein kinase, putative; 12576-15979; ... 82 1e-13
UniRef50_Q9BI25 Cluster: SHK1 protein; n=2; Dictyostelium discoi... 82 1e-13
UniRef50_Q0EZJ3 Cluster: Adenylate cyclase; n=1; Mariprofundus f... 81 1e-13
UniRef50_A5V6C5 Cluster: Putative adenylate/guanylate cyclase; n... 81 1e-13
UniRef50_A7Q5T6 Cluster: Chromosome chr14 scaffold_54, whole gen... 81 1e-13
UniRef50_Q54Y55 Cluster: SH2 domain-containing protein; n=1; Dic... 81 1e-13
UniRef50_Q24GP9 Cluster: Adenylate and Guanylate cyclase catalyt... 81 1e-13
UniRef50_Q67W58 Cluster: Putative ethylene-inducible CTR1-like p... 81 2e-13
UniRef50_A2F7J9 Cluster: Adenylate and Guanylate cyclase catalyt... 81 2e-13
UniRef50_Q98GL0 Cluster: Mlr3277 protein; n=5; Rhizobiales|Rep: ... 81 2e-13
UniRef50_A0NQ18 Cluster: Putative uncharacterized protein; n=1; ... 81 2e-13
UniRef50_Q54WS5 Cluster: Pleckstrin homology (PH) domain-contain... 81 2e-13
UniRef50_Q54F62 Cluster: RasGEF domain-containing protein; n=2; ... 81 2e-13
UniRef50_UPI000155C8D4 Cluster: PREDICTED: similar to Receptor (... 80 3e-13
UniRef50_A7BYP5 Cluster: Adenylate/guanylate cyclase; n=1; Beggi... 80 3e-13
UniRef50_A4BIA0 Cluster: Adenylate/guanylate cyclase; n=1; Reine... 80 3e-13
UniRef50_A0LQP8 Cluster: Adenylate/guanylate cyclase; n=1; Syntr... 80 3e-13
UniRef50_Q5CRV8 Cluster: Membrane associated adenyl cyclase with... 80 3e-13
UniRef50_Q9JK77 Cluster: Adenylyl cyclase 3; n=7; Euteleostomi|R... 80 4e-13
UniRef50_A7QMH3 Cluster: Chromosome chr19 scaffold_126, whole ge... 80 4e-13
UniRef50_A7PZD6 Cluster: Chromosome chr15 scaffold_40, whole gen... 80 4e-13
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 79 6e-13
UniRef50_Q09E49 Cluster: Adenylate cyclase 2; n=2; Stigmatella a... 79 6e-13
UniRef50_A6GEM5 Cluster: Adenylate cyclase; n=1; Plesiocystis pa... 79 6e-13
UniRef50_Q13546 Cluster: Receptor-interacting serine/threonine-p... 79 6e-13
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 79 8e-13
UniRef50_Q3E5U5 Cluster: PAS:Adenylyl cyclase class-3/4/guanylyl... 79 1e-12
UniRef50_Q09BE7 Cluster: Adenylate cyclase 1; n=1; Stigmatella a... 79 1e-12
UniRef50_Q9ZSD8 Cluster: Ethylene-inducible CTR1-like protein ki... 79 1e-12
UniRef50_Q5XTZ4 Cluster: Salt-inducible protein kinase; n=2; Poa... 79 1e-12
UniRef50_Q7A2D9 Cluster: Adenylate cyclase; n=6; Cyanobacteria|R... 78 1e-12
UniRef50_Q0IZJ5 Cluster: Os09g0566500 protein; n=9; Magnoliophyt... 78 1e-12
UniRef50_A7R2R7 Cluster: Chromosome chr4 scaffold_443, whole gen... 78 1e-12
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 78 1e-12
UniRef50_A0NUX8 Cluster: Adenylate cyclase 1 protein; n=1; Stapp... 78 2e-12
UniRef50_Q9SAJ2 Cluster: T8K14.1 protein; n=3; Arabidopsis thali... 78 2e-12
UniRef50_Q012D5 Cluster: Tyrosine kinase specific for activated ... 78 2e-12
UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gamb... 78 2e-12
UniRef50_A6GG85 Cluster: Putative adenylate cyclase; n=1; Plesio... 77 2e-12
UniRef50_A1WTT4 Cluster: Putative Chase2 sensor protein precurso... 77 2e-12
UniRef50_Q9LRY7 Cluster: Similarity to protein kinase; n=3; Arab... 77 2e-12
UniRef50_Q01JS4 Cluster: OSIGBa0152L12.10 protein; n=4; Oryza sa... 77 2e-12
UniRef50_O65833 Cluster: TCTR2 protein; n=2; Solanum lycopersicu... 77 3e-12
UniRef50_A7NZL4 Cluster: Chromosome chr6 scaffold_3, whole genom... 77 3e-12
UniRef50_A7NXT1 Cluster: Chromosome chr5 scaffold_2, whole genom... 77 3e-12
UniRef50_Q54U31 Cluster: SH2 domain-containing protein; n=1; Dic... 77 3e-12
UniRef50_Q9FKL3 Cluster: Similarity to protein kinase; n=1; Arab... 77 4e-12
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 77 4e-12
UniRef50_Q8EXW3 Cluster: Adenylate cyclase; n=2; Leptospira inte... 76 5e-12
UniRef50_Q0VSG5 Cluster: Adenylate cyclase family proteine ident... 76 5e-12
UniRef50_Q04UM6 Cluster: Adenylate cyclase related protein; n=4;... 76 5e-12
UniRef50_A6G1S4 Cluster: Putative adenylate cyclase; n=1; Plesio... 76 5e-12
UniRef50_Q23AD7 Cluster: Protein kinase domain containing protei... 76 5e-12
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 76 7e-12
UniRef50_Q39P44 Cluster: Adenylate/guanylate cyclase; n=9; Burkh... 76 7e-12
UniRef50_A0LAQ0 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 76 7e-12
UniRef50_Q0DE32 Cluster: Os06g0181200 protein; n=5; Oryza sativa... 76 7e-12
UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77; E... 76 7e-12
UniRef50_Q1N6Q8 Cluster: Probable adenylate cyclase; n=1; Oceano... 75 9e-12
UniRef50_A1T6C4 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 75 9e-12
UniRef50_A0P1E4 Cluster: Putative Adenylate/Guanylate cyclase; n... 75 9e-12
UniRef50_Q54IP4 Cluster: SH2 domain-containing protein; n=1; Dic... 75 9e-12
UniRef50_A2E2L8 Cluster: TKL family protein kinase; n=1; Trichom... 75 9e-12
UniRef50_UPI000051A5F5 Cluster: PREDICTED: similar to CG9783-PA,... 75 1e-11
UniRef50_Q9SA26 Cluster: F3O9.7 protein; n=3; Arabidopsis thalia... 75 1e-11
UniRef50_Q00Y29 Cluster: Protein kinase family protein; n=1; Ost... 75 1e-11
UniRef50_O64768 Cluster: Putative uncharacterized protein At2g35... 75 1e-11
UniRef50_P04629 Cluster: High affinity nerve growth factor recep... 75 1e-11
UniRef50_Q89II7 Cluster: Bll5647 protein; n=5; Bradyrhizobiaceae... 75 2e-11
UniRef50_A4S4H8 Cluster: Predicted protein; n=2; Ostreococcus|Re... 75 2e-11
UniRef50_Q8YVS0 Cluster: Adenylate cyclase; n=6; Cyanobacteria|R... 74 2e-11
UniRef50_A0LB38 Cluster: Adenylate/guanylate cyclase; n=1; Magne... 74 2e-11
UniRef50_Q9FIL6 Cluster: Protein-tyrosine kinase; n=10; core eud... 74 2e-11
UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1; ... 74 2e-11
UniRef50_UPI00006CE4F4 Cluster: Protein kinase domain containing... 74 3e-11
UniRef50_Q9HZ23 Cluster: CyaB; n=13; Gammaproteobacteria|Rep: Cy... 74 3e-11
UniRef50_Q3W2Y3 Cluster: Guanylate cyclase:Response regulator re... 74 3e-11
UniRef50_A7IGJ6 Cluster: Putative Chase2 sensor protein precurso... 74 3e-11
UniRef50_Q5ZVW6 Cluster: Adenylate cyclase 1 protein; n=4; Legio... 73 4e-11
UniRef50_Q1YP13 Cluster: Probable adenylate cyclase; n=1; gamma ... 73 4e-11
UniRef50_A4BGN9 Cluster: Adenylate cyclase, family 3; n=1; Reine... 73 4e-11
UniRef50_Q5CUX5 Cluster: P-type ATpase fused to two adenyl cycla... 73 4e-11
UniRef50_A0Y8Z4 Cluster: Adenylate cyclase; n=1; marine gamma pr... 73 5e-11
UniRef50_A0PTR6 Cluster: Adenylylate/guanylate cyclase; n=1; Myc... 73 5e-11
UniRef50_A4SBG1 Cluster: Predicted protein; n=2; Ostreococcus|Re... 73 5e-11
UniRef50_Q55EI8 Cluster: Filamin/ABP280 repeat-containing protei... 73 5e-11
UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona intestinali... 73 5e-11
UniRef50_A0DHI3 Cluster: Chromosome undetermined scaffold_50, wh... 73 5e-11
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 73 5e-11
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 73 5e-11
UniRef50_UPI00006A1DD3 Cluster: UPI00006A1DD3 related cluster; n... 73 7e-11
UniRef50_A0PW43 Cluster: Conserved hypothetical transmembrane pr... 73 7e-11
UniRef50_Q9LYI8 Cluster: MAP3K delta-1 protein kinase; n=3; Arab... 73 7e-11
UniRef50_Q01A76 Cluster: Putative CTR1-like protein kinase; n=1;... 73 7e-11
UniRef50_Q55E58 Cluster: Leucine-rich repeat-containing protein;... 73 7e-11
UniRef50_Q54XX5 Cluster: Ankyrin repeat-containing protein; n=1;... 73 7e-11
UniRef50_P11346 Cluster: Raf homolog serine/threonine-protein ki... 73 7e-11
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 73 7e-11
UniRef50_Q0F3A7 Cluster: Adenylate/guanylate cyclase; n=1; Marip... 72 9e-11
UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n... 72 9e-11
UniRef50_A2G3F5 Cluster: Adenylate and Guanylate cyclase catalyt... 72 9e-11
UniRef50_A2FGN8 Cluster: TKL family protein kinase; n=2; Trichom... 72 9e-11
UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-prote... 72 9e-11
UniRef50_UPI0000F207C8 Cluster: PREDICTED: similar to topoisomer... 72 1e-10
UniRef50_Q73L79 Cluster: Adenylate cyclase, putative; n=1; Trepo... 72 1e-10
UniRef50_A0WBT7 Cluster: Adenylate/guanylate cyclase precursor; ... 72 1e-10
UniRef50_A7Q6K4 Cluster: Chromosome chr11 scaffold_56, whole gen... 72 1e-10
UniRef50_Q5BXY8 Cluster: SJCHGC07735 protein; n=1; Schistosoma j... 72 1e-10
UniRef50_Q7UN49 Cluster: Adenylate cyclase 1; n=1; Pirellula sp.... 71 2e-10
UniRef50_Q2LSB8 Cluster: Adenylate and guanylate cyclase catalyt... 71 2e-10
UniRef50_O83498 Cluster: Adenylate cyclase; n=1; Treponema palli... 71 2e-10
UniRef50_Q3DXI8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 71 2e-10
UniRef50_A7C3X9 Cluster: Adenylyl cyclase class-3/4/guanylyl cyc... 71 2e-10
UniRef50_Q9LVQ9 Cluster: Protein kinase ATN1-like protein; n=4; ... 71 2e-10
UniRef50_Q5W6K6 Cluster: Kinase domain containing protein; n=2; ... 71 2e-10
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 71 2e-10
UniRef50_A2DNM3 Cluster: TKL family protein kinase; n=1; Trichom... 71 2e-10
UniRef50_A0CL90 Cluster: Chromosome undetermined scaffold_20, wh... 71 2e-10
UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase ... 71 2e-10
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 71 2e-10
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 71 2e-10
UniRef50_Q2BGD8 Cluster: Adenylate cyclase; n=1; Neptuniibacter ... 71 2e-10
>UniRef50_Q8IT60 Cluster: Guanylate cyclase; n=3; Coelomata|Rep:
Guanylate cyclase - Manduca sexta (Tobacco hawkmoth)
(Tobacco hornworm)
Length = 1258
Score = 1237 bits (3065), Expect = 0.0
Identities = 681/1271 (53%), Positives = 787/1271 (61%), Gaps = 78/1271 (6%)
Query: 27 SVHAHAGPPALLVLRSGC---------------FRQ--DLPRLHPIPRATLLSHQETCDV 69
+V A PPALLVLR+ C FRQ + R +P LLS+ +TC V
Sbjct: 9 AVAAALRPPALLVLRAACSVPSTSNSDAFDAARFRQFASVQRTTLMP-VKLLSYHDTCGV 67
Query: 70 GWNERVTRRAVSTLTDGGLVEIIGWPGAAVCESISVTASVLRRPQPASCXXXXXXXXXXX 129
W E V R A+STL GGLVE +GWPG +VC ++S A VLRRP PA C
Sbjct: 68 SWRESVARTALSTLGAGGLVECVGWPGTSVCGAMSAAARVLRRPVPAECARVGSRAHAVA 127
Query: 130 XXXXXXXXX------XXXXXXXXXSSDCEAAXXXXXXXXXXXXXXVRRAMLSARAFADRP 183
+ +C AA VR A R
Sbjct: 128 ELARRLRWSRVLLPPATADSTALTAPECNAALLEVARALSATGATVRYMTAEASDLQRRS 187
Query: 184 EVLILCVSVAAKIGSKIESMLKDTDVVILLL---HFEELM-------RDATDFA-NKDIE 232
V+ILC S + E D ++LLL H ATD A +KD +
Sbjct: 188 HVVILCTSTGSNRSQDTEQSFSGADALLLLLVQGHPTNHQGSGGANNTSATDVAGDKDTK 247
Query: 233 NFKTMKSESIKASKVNYSSDSTSEREINDHKLNHEMVQNLNSPLSFYNIHRKMQIRSGKS 292
+ + + S +++ + E+ I H+ + L I I +G +
Sbjct: 248 SIPNVTTHSSSGERLDSTMPINGEKHIFKHRTTSPFHE-----LDSLKISSNGTIVTG-A 301
Query: 293 SMNSTELSTNQLIVPFTKPSEGNQTEPANIVHEGTRSLDDRRDARGTTMSTKHAEIESSQ 352
S+ S + N+ + + T+P +SLD+ T + E+ +
Sbjct: 302 SVASMDDDHNKKVYQILTTARNQTTKP--------KSLDNNSHLHVVTGQQQVQEVSLKE 353
Query: 353 TLQISKKDLRYLEIFSHFNDLFPGWLLILSENIFVEEHLTS-DSISEKVTKVLESVEESE 411
+ +L P +L+L + EH S D++ ++LE ++
Sbjct: 354 SASDVIDELD--ASLDRLGKALPNRVLVLRDAGLGNEHARSVDALHAAALRLLERAAIAD 411
Query: 412 RARQQSVQRRFLLYVRSGDRSAWSXXXXXXXXXXXXXDGDRPWAATVALHD-WHALERWN 470
RA QS++ + LY R+ +SAW D D W +V HD AL+RWN
Sbjct: 412 RAHLQSLRTMYPLYGRNDLQSAWRLIATLDATSVRQLDEDVDWVTSVEFHDKGDALQRWN 471
Query: 471 GTKPEDERDHWNG-SNIXXXXXXXXXXXXXXXXXXXXXRWEAVXXXXXXXXEYVVLTPLH 529
T D RD + + + R VL P
Sbjct: 472 AT--HDGRDGESVFAGLIATLLAAAGAAALASGVALGARLLMARRRRRRRRGDAVLAPAD 529
Query: 530 FTFPADEARRVGEGMETMLSCWLQQLHEFGGPELERPDLLKRPGVTARVPSAPSSTCSVN 589
FTFPADE RRVGEGMETMLSCWL+QLHEFGGPELERPDLLK+P + RVPS PSSTCSVN
Sbjct: 530 FTFPADERRRVGEGMETMLSCWLKQLHEFGGPELERPDLLKQPAASPRVPSVPSSTCSVN 589
Query: 590 RVVVDRRIRYKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPA 649
R + DRR RY+GDAVHL+ L ELKRK+ DVLL+MQ+LR EN+NPFIGCLC+ RPA
Sbjct: 590 RTIADRRTRYRGDAVHLKCLPAASAFELKRKAIDVLLVMQSLRHENINPFIGCLCDNRPA 649
Query: 650 LVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVD 709
LVFD C RGSLEDVL ADDIKLDWTFRLSLL+DLVKGMRYLH SPLR HGRLSSR+CVVD
Sbjct: 650 LVFDYCGRGSLEDVLTADDIKLDWTFRLSLLTDLVKGMRYLHASPLRVHGRLSSRSCVVD 709
Query: 710 SRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFA 769
SRWVLRV+DYGLPA +R Q LP +R+ RELLWTAPEL+RE R GGGW ATQ GDVFSFA
Sbjct: 710 SRWVLRVSDYGLPAFYRAQALPQPERSARELLWTAPELLRERRGGGGWGATQPGDVFSFA 769
Query: 770 IIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPD 829
IIMQEVIVRGEPYCML+ TP+EI++K+ RPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPD
Sbjct: 770 IIMQEVIVRGEPYCMLALTPDEIVEKVSRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPD 829
Query: 830 LRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLL 889
LRPDFNRLHDVFR M RGRKINIVDSMFEMLEKYSNNLEELI+ERTEQLDMEKKKTEQLL
Sbjct: 830 LRPDFNRLHDVFRHMHRGRKINIVDSMFEMLEKYSNNLEELIKERTEQLDMEKKKTEQLL 889
Query: 890 NRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFD 949
NRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARST VQVVDLLNDLYTTFD
Sbjct: 890 NRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTPVQVVDLLNDLYTTFD 949
Query: 950 AAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLH 1009
AAIEQYRVYKVETIGDAYMVVGGLP+R RDHAESVATMALHLLHLAGRFRVRHLPDTPLH
Sbjct: 950 AAIEQYRVYKVETIGDAYMVVGGLPKRARDHAESVATMALHLLHLAGRFRVRHLPDTPLH 1009
Query: 1010 LRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGY 1069
LRIGLH+GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQ S+ TAEKLLAAGGY
Sbjct: 1010 LRIGLHSGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQTSAATAEKLLAAGGY 1069
Query: 1070 KLRSRGLTQIKGKGAMHTYWLLGKEGFD----------XXXXXXXXXDCXXXXX--XXXX 1117
+LRSRGLTQIKGKGAMHTYWLLGKEGFD +C
Sbjct: 1070 RLRSRGLTQIKGKGAMHTYWLLGKEGFDRPLPTPPPLESEEEILVEAECEVDDQEPVSRT 1129
Query: 1118 XXXXXXXXXVDSG--LSSASPDNRPAPYLTSSEQSRRPVSSATSADSCSPPPEPRGSRAL 1175
D+ + SP++ P + S P+ S TS + P R
Sbjct: 1130 ISPSTHSTTPDTAVVMDGCSPESATLPKMCELMGSMSPM-SPTSTTALEALP-----RGP 1183
Query: 1176 LPTTSVDHSAPYARYRWLGGNARTLKRQWSLERGDXXXXXXXXXXXXG--SRVTPRHAPR 1233
L SVDHSA YARYRWL G AR+L+RQWSLERG+ + VTPR APR
Sbjct: 1184 LHGASVDHSAAYARYRWLPGGARSLRRQWSLERGEALAAAAASAEPLALVAGVTPRSAPR 1243
Query: 1234 YRTRAEPADDD 1244
YRTR + +D+
Sbjct: 1244 YRTRRDQREDE 1254
>UniRef50_UPI0000D5787E Cluster: PREDICTED: similar to CG9783-PA; n=2;
Endopterygota|Rep: PREDICTED: similar to CG9783-PA -
Tribolium castaneum
Length = 1044
Score = 838 bits (2074), Expect = 0.0
Identities = 394/581 (67%), Positives = 472/581 (81%), Gaps = 10/581 (1%)
Query: 523 VVLTPLHFTFPA-DEARRVGEGMETMLSCWLQQLHEFGGPELERPDLLKRPGVTARVPSA 581
V+LT F FP ++RRV EG+E ML CWLQQL EFGGPE+++PDLL+ G + + P
Sbjct: 458 VLLTATDFVFPQIADSRRVDEGIEAMLCCWLQQLQEFGGPEVDKPDLLQGSGASVKTPLR 517
Query: 582 PSSTCSV-NRVVVDRRIRYKGDAVHLRHL-QVTGTLELKRKSTDVLLLMQNLRQENVNPF 639
S+ ++ +++VD R+RY GD V ++ + GT+ELK K+ ++L+L+ LR EN+NP
Sbjct: 518 GGSSPNLAKQLIVDPRVRYNGDLVQMKPVPSAGGTVELKAKTVELLVLLHGLRHENLNPL 577
Query: 640 IGCLCEG-RPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAH 698
IGCL E R ALV + C RGSL+DVL DDIKLDW+FRLSLL+DLV+GM+YLH +P+R H
Sbjct: 578 IGCLAEPPRAALVSEYCARGSLQDVLQQDDIKLDWSFRLSLLTDLVRGMKYLHSTPIRVH 637
Query: 699 GRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREA--REGGG 756
G L+SRNCV+D+RWVL+VTDYGLPA + QG+ P +T RELLWTAPEL+R A R+ G
Sbjct: 638 GYLTSRNCVIDARWVLKVTDYGLPAFYEAQGMQPPAKTARELLWTAPELLRHASLRKKG- 696
Query: 757 WLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSVSMGAAPPEA 816
TQ GDV+SF I++QEV+VRGEP+CML+ TPEEII+K+ RPPPLIRPSVS GAAPPEA
Sbjct: 697 ---TQPGDVYSFGIVLQEVVVRGEPFCMLALTPEEIIEKVKRPPPLIRPSVSKGAAPPEA 753
Query: 817 VSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTE 876
+++MRQCW+E ++RPDFN +HD F+++ GRK+NIVD+MF+MLEKYSNNLEELIRERTE
Sbjct: 754 INIMRQCWAEQAEMRPDFNTVHDQFKKLNHGRKVNIVDTMFQMLEKYSNNLEELIRERTE 813
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQ 936
QLD+EKKKTEQLLNRMLP SVAE+L LG V+PEEFEEV+IYFSDIVGFT ++A ST Q
Sbjct: 814 QLDIEKKKTEQLLNRMLPSSVAEKLKLGMPVDPEEFEEVTIYFSDIVGFTTISAHSTPFQ 873
Query: 937 VVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAG 996
VVDLLNDLYT FDA I Y VYKVETIGDAYMVVGGLP R DHAE +ATMAL LLH +G
Sbjct: 874 VVDLLNDLYTCFDATINAYNVYKVETIGDAYMVVGGLPVRVPDHAEQIATMALDLLHQSG 933
Query: 997 RFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
RFR+ HLP TPL LRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRI +S
Sbjct: 934 RFRITHLPGTPLRLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIHLS 993
Query: 1057 STTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEGFD 1097
T E+L AGGY+L RG T+IKGKG MHTYWLLGK GFD
Sbjct: 994 EATKERLEKAGGYQLEYRGPTEIKGKGTMHTYWLLGKAGFD 1034
>UniRef50_Q9VN32 Cluster: Guanylate cyclase; n=5; Diptera|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 975
Score = 774 bits (1913), Expect = 0.0
Identities = 374/585 (63%), Positives = 449/585 (76%), Gaps = 34/585 (5%)
Query: 547 MLSCWLQQLHEFGGPELERPDLLK-----------------RPG------VTARVPSAPS 583
ML CWLQQL EFGGPE+++PDLLK PG TA S S
Sbjct: 1 MLCCWLQQLQEFGGPEVDKPDLLKGSIGSLKNLGFVIPGAAAPGSAGAITTTANGKSGSS 60
Query: 584 STCSV---NRVVVDRRIRYKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFI 640
+T S+ N +D R RY GD V L+ + + G+ EL+ K+ D+L++ LR EN+NP I
Sbjct: 61 ATGSLARHNPAHLDMRARYNGDLVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLI 120
Query: 641 GCLCE-GRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHG 699
G L + R A+VFD C RGSL+DVL+ D+IKLDW+FRLSLL+DLV+GMRYLH SPLR HG
Sbjct: 121 GWLSDPNRTAMVFDYCSRGSLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHG 180
Query: 700 RLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAR------- 752
L+SRNCVVD+RWVL++TDYGL + + +QGLPP R+ +ELLWTAPEL+R +
Sbjct: 181 ALTSRNCVVDARWVLKITDYGLNSFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQ 240
Query: 753 EGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSVSMGAA 812
G L TQ GDV+SF IIMQEV+VRGEPYCMLS +PEEII K+ +PPPLIRPSVS GAA
Sbjct: 241 HGRIQLGTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAA 300
Query: 813 PPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIR 872
PPEA+++MRQCW+E PD+RPDFN +++ F+ + GRK+N VD+MF+MLEKYSNNLEELIR
Sbjct: 301 PPEAINIMRQCWAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIR 360
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARS 932
ERTEQLD+E+KKTEQLLNRMLP SVAE+L +G V+PEEF +V+IYFSDIVGFT +AA
Sbjct: 361 ERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHC 420
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLL 992
+ VQVVDLLNDLYT FDA I Y VYKVETIGDAYMVV GLP + DHAE +ATMAL LL
Sbjct: 421 SPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLL 480
Query: 993 HLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWR 1052
H +GRF V+HLP PL LRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG++WR
Sbjct: 481 HQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWR 540
Query: 1053 IQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEGFD 1097
I +S T ++L A GGY + RGL IKGKG M+T+WLLGK+GFD
Sbjct: 541 IHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFD 585
>UniRef50_P51841 Cluster: Retinal guanylyl cyclase 2 precursor; n=48;
Euteleostomi|Rep: Retinal guanylyl cyclase 2 precursor -
Homo sapiens (Human)
Length = 1108
Score = 562 bits (1387), Expect = e-158
Identities = 276/504 (54%), Positives = 365/504 (72%), Gaps = 9/504 (1%)
Query: 599 YKGDAVHLRHLQVT--GTLE-LKRKSTDVLLLMQNLRQENVNPFIGCLCE-GRPALVFDE 654
Y+GD V L+ + G L+ +K +++DV +M++LR EN+NP +G + G A+V +
Sbjct: 566 YEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEF 625
Query: 655 CWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVL 714
C RGSLED+L D+KLDW F+ SLL DL+KGM+YLH HGRL SRNCVVD R+VL
Sbjct: 626 CSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREF-VHGRLKSRNCVVDGRFVL 684
Query: 715 RVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQE 774
+VTDYG + L + + ELLWTAPEL+R R G L + +GDV+SFAIIMQE
Sbjct: 685 KVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPR--GSRLGSFAGDVYSFAIIMQE 742
Query: 775 VIVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDF 834
V+VRG P+CM+ +EII++L +PPP+ RP V APPE + +M+QCW+EA + RP F
Sbjct: 743 VMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTF 802
Query: 835 NRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLP 894
+ + + F+ +G+K NI+DSM MLE+YS+NLE+LIRERTE+L++EK+KTE+LL +MLP
Sbjct: 803 DEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLP 862
Query: 895 RSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQ 954
SVAE L G VEPE F+ V++YFSDIVGFT ++A S ++VVDLLNDLYT FDA I
Sbjct: 863 PSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGS 922
Query: 955 YRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIG 1013
+ VYKVETIGDAYMV GLP+R HA +A M+L +L G F++RH+P+ P+ +RIG
Sbjct: 923 HDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIG 982
Query: 1014 LHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLL-AAGGYKLR 1072
LH+GP AGVVGLTMPRYCLFGDTVNTASRMESTG +RI +S +T L + GY++
Sbjct: 983 LHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042
Query: 1073 SRGLTQIKGKGAMHTYWLLGKEGF 1096
RG T++KGKG T+WL+GK+GF
Sbjct: 1043 LRGRTELKGKGTEETFWLIGKKGF 1066
>UniRef50_Q02846 Cluster: Retinal guanylyl cyclase 1 precursor; n=23;
Eukaryota|Rep: Retinal guanylyl cyclase 1 precursor -
Homo sapiens (Human)
Length = 1103
Score = 557 bits (1374), Expect = e-157
Identities = 277/513 (53%), Positives = 361/513 (70%), Gaps = 18/513 (3%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-----------CLCEGR 647
Y+GD V L+ + ++ + +Q LR ENV ++G L EG
Sbjct: 555 YEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGN 614
Query: 648 PALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCV 707
A+V + C RGSL+D+L +IKLDW F+ SLL DL+KG+RYLH + AHGRL SRNC+
Sbjct: 615 LAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGV-AHGRLKSRNCI 673
Query: 708 VDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIRE-AREGGGWLATQSGDVF 766
VD R+VL++TD+G L Q + P + LWTAPEL+R+ A E G LA GDVF
Sbjct: 674 VDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLA---GDVF 730
Query: 767 SFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQCWSE 826
S AIIMQEV+ R PY ML TPEE++ ++ PPPL RP VSM AP E + +M+QCW+E
Sbjct: 731 SLAIIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAE 790
Query: 827 APDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTE 886
P+LRP + D+F+ + +GRK NI+DSM MLE+YS+NLE+LIRERTE+L++EK+KT+
Sbjct: 791 QPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTD 850
Query: 887 QLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYT 946
+LL +MLP SVAE L G+ VEPE FE+V++YFSDIVGFT ++A S ++VVDLLNDLYT
Sbjct: 851 RLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYT 910
Query: 947 TFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPD 1005
FDA I + VYKVETIGDAYMV GLPQR + HA +A M+L +L G FR+RH+P+
Sbjct: 911 LFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPE 970
Query: 1006 TPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLA 1065
P+ +RIGLH+GPC AGVVGLTMPRYCLFGDTVNTASRMESTG +RI ++ +T L A
Sbjct: 971 VPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRA 1030
Query: 1066 A-GGYKLRSRGLTQIKGKGAMHTYWLLGKEGFD 1097
GY++ RG T++KGKGA T+WL+G+ GF+
Sbjct: 1031 LDSGYQVELRGRTELKGKGAEDTFWLVGRRGFN 1063
>UniRef50_A2BFQ0 Cluster: Guanylate cyclase; n=3; Danio rerio|Rep:
Guanylate cyclase - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 1176
Score = 535 bits (1321), Expect = e-150
Identities = 260/504 (51%), Positives = 355/504 (70%), Gaps = 11/504 (2%)
Query: 600 KGDAVHLRHLQVTGTL-ELKRKSTDVLLLMQNLRQENVNPFIGCLCE-GRPALVFDECWR 657
KGD V L+ ++ E+ + + + ++++R EN+N F+G + G +V + C R
Sbjct: 638 KGDWVWLKKCPCADSITEISESTQTIFVKLRDMRHENLNLFLGLFMDTGIFGIVTEHCTR 697
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
GSLED+L ++++LDW F+ SLL DL++GM+YLH + HGRL SRNCVVD R+VL+VT
Sbjct: 698 GSLEDLLNNEEMRLDWMFKSSLLLDLIRGMKYLHNRGI-IHGRLKSRNCVVDGRFVLKVT 756
Query: 718 DYGLPALHRTQGLPPAQRTPRELLWTAPELIR--EAREGGGWLATQSGDVFSFAIIMQEV 775
DYG + Q + P + WTAPE++R + ++ G T GDV+SF+IIMQEV
Sbjct: 757 DYGFNEILNCQNIILEDNAPEDQFWTAPEILRNPDLKKKG----TYPGDVYSFSIIMQEV 812
Query: 776 IVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFN 835
I R P+CML PEEII+K+ PPPL RP+VSM AP + + +M+Q WSE P+ RP F
Sbjct: 813 ISRCAPFCMLDMPPEEIIEKVRSPPPLCRPTVSMDEAPLDVIQLMKQAWSEEPEQRPTFE 872
Query: 836 RLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPR 895
+ F+ M +G+K NI+DSM MLE+YS+NLE+LIRERTE+L++E++KT+ LL +MLP+
Sbjct: 873 DIFRQFKSMNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVERQKTDALLAQMLPK 932
Query: 896 SVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQY 955
SVA L G V+PE F EV++YFSDIVGFT ++A S ++VVDLLNDLYT FD I +
Sbjct: 933 SVALALKTGKPVKPEHFAEVTLYFSDIVGFTTISALSEPIEVVDLLNDLYTHFDGIIAIH 992
Query: 956 RVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGL 1014
VYKVETIGDAYMV G+P R HA +A M+L +LH G F++RH+PD + +RIGL
Sbjct: 993 DVYKVETIGDAYMVASGVPNRNGTRHAAEMANMSLDILHCIGTFKMRHMPDVKVKIRIGL 1052
Query: 1015 HTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAG-GYKLRS 1073
H+GP AGVVGL MPRYCLFGDTVNTASRMESTG +RI ++ +T + L + GYK+ +
Sbjct: 1053 HSGPVVAGVVGLKMPRYCLFGDTVNTASRMESTGLPYRIHVNQSTVDVLNSLKLGYKIDT 1112
Query: 1074 RGLTQIKGKGAMHTYWLLGKEGFD 1097
RG T++KGKG T+WL+G++GFD
Sbjct: 1113 RGRTELKGKGVEETFWLVGRDGFD 1136
>UniRef50_Q4SY29 Cluster: Guanylate cyclase; n=2; Tetraodontidae|Rep:
Guanylate cyclase - Tetraodon nigroviridis (Green puffer)
Length = 1103
Score = 530 bits (1308), Expect = e-149
Identities = 252/452 (55%), Positives = 329/452 (72%), Gaps = 5/452 (1%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCE-GRPALVFDECWR 657
Y+GD V L+ Q E+K+ +T +L M++LR ENVNPF+G + A+V + C R
Sbjct: 539 YEGDWVWLKKFQEGHFKEVKQSTTKILTKMKDLRNENVNPFLGFFSDCSMFAVVTEHCSR 598
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
GSL+D+L +D+KLDW F+ SLL DL+KGM+YLH AHGRL SRNCVVD R+VL++T
Sbjct: 599 GSLQDLLRNEDVKLDWMFKSSLLLDLIKGMKYLHHRDF-AHGRLKSRNCVVDGRFVLKIT 657
Query: 718 DYGLPALHRTQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIV 777
DYG L Q P + P EL WTAPE +R+ T GDV+SF+II+QEV+V
Sbjct: 658 DYGFNELLECQKAPLEEPPPEELFWTAPEFLRDITSTRK--GTSKGDVYSFSIILQEVVV 715
Query: 778 RGEPYCMLSFTPEEIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRL 837
RG PYCML EII K+ +PPP+ RP+V+ AP E + +M+QCWSE P+ RP F+ +
Sbjct: 716 RGPPYCMLGLPANEIIRKVKKPPPMCRPTVAPDQAPLECIQLMKQCWSELPERRPTFDEI 775
Query: 838 HDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSV 897
D F+ + +G+K NI+DSM MLE+YS+NLE+LIRERTE+L++EK++TE+LL+ MLP SV
Sbjct: 776 FDRFKLINKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSV 835
Query: 898 AERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRV 957
AE L G VEPE F++V+IYFSDIVGFT +++ S ++VVDLLNDLY+ FDA + + V
Sbjct: 836 AEALKTGGTVEPEYFDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLSSHDV 895
Query: 958 YKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT 1016
YKVETIGDAYMV GLP+R HA +A M+L++L G F +RH+PD P+ +RIG+H+
Sbjct: 896 YKVETIGDAYMVASGLPKRNGNKHAAEIANMSLNILSSVGTFHMRHMPDVPVRIRIGIHS 955
Query: 1017 GPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
G C AGVVGLTMPRYCLFGDTVNTASRMESTG
Sbjct: 956 GACVAGVVGLTMPRYCLFGDTVNTASRMESTG 987
>UniRef50_A7SPS9 Cluster: Predicted protein; n=11; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 518
Score = 483 bits (1190), Expect = e-134
Identities = 255/508 (50%), Positives = 329/508 (64%), Gaps = 15/508 (2%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVFDECWR 657
YK + V ++ + +EL R+ + LM+ +R EN+ F G C+ ++ C +
Sbjct: 14 YKSNMVAIKRINKR-QIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPK 72
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
GSL+D+L +DIKLD F SLL+D+VKGM YLH + +R+HGRL S NCVVD RWVL++T
Sbjct: 73 GSLQDILENEDIKLDSMFVNSLLTDIVKGMAYLHSTEIRSHGRLKSPNCVVDGRWVLKIT 132
Query: 718 DYGLPALHRTQGLPPAQRTPR---ELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQE 774
DYGL Q + + LWTAPEL+R A TQ GDV+SF II+QE
Sbjct: 133 DYGLNKFKSNQDISEEEGEYAMYYRKLWTAPELLRAADPRPR--GTQKGDVYSFGIIVQE 190
Query: 775 VIVRGEPYCMLSFT--PEEIIDKLCR-PPPLIRPSVSM----GAAPPEAVSVMRQCWSEA 827
++ R P+ + +T P +II+K+ R P RP +S G V + + CW E
Sbjct: 191 LLTRSGPFDLSYYTNEPSDIIEKVTRVESPPFRPKLSTIVLEGPTVAGIVDLAKWCWEEN 250
Query: 828 PDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQ 887
PD RPDF + R++ G++ NI+D+M +LEKY+NNLE L+ ERT QL EK+KTE
Sbjct: 251 PDHRPDFEEIRKTVRKLPMGKQSNIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTEN 310
Query: 888 LLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTT 947
LLNRMLP SVA+ L+ G +V E F+EVSI+FSDIVGFT+L++ ST +QVVDLLNDLYT
Sbjct: 311 LLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTL 370
Query: 948 FDAAIEQYRVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDT 1006
FD I Y VYKVETIGDAYMVV GLP R HA +ATMALH+L F++RH P+
Sbjct: 371 FDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPND 430
Query: 1007 PLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAA 1066
L LRIG+H+G C AGVVG MPRYCLFGDTVNTASRMES G A +I IS +T L
Sbjct: 431 KLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDEL 490
Query: 1067 GGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
GGY ++ RG +KGKG TYWL+G +
Sbjct: 491 GGYHIQKRGKVFLKGKGTWITYWLVGSD 518
>UniRef50_Q4TAT8 Cluster: Guanylate cyclase; n=2; Tetraodontidae|Rep:
Guanylate cyclase - Tetraodon nigroviridis (Green puffer)
Length = 1154
Score = 476 bits (1174), Expect = e-132
Identities = 257/544 (47%), Positives = 354/544 (65%), Gaps = 54/544 (9%)
Query: 600 KGDAVHLRHLQVTGTLELKRKSTDVLLL-MQNLRQENVNPFIGCLCE-GRPALVFDECWR 657
+GD V L+ + V TL +T L ++ +R EN+N ++G + G ALV + C R
Sbjct: 589 EGDWVWLKKIPVGRTLPAVNHNTKNLFSQLREMRHENLNLYLGLFLDSGIFALVEEHCPR 648
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVK--------------------GMRYLHGSPLRA 697
GSL D+L +++LDW F+ SLL DL+K GM+YLH L
Sbjct: 649 GSLADLLSDPNMRLDWMFKSSLLMDLIKVSGGHRGVGVQQCLTPSGFQGMKYLHLRGL-C 707
Query: 698 HGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLP------------------PAQRTPR- 738
HGRL S NC+VD R+VL+VTDYGLP + +Q L P + + R
Sbjct: 708 HGRLKSTNCLVDGRFVLKVTDYGLPMILHSQNLQVPEDEQGSQQADVKPVAFPGRLSDRA 767
Query: 739 ---ELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDK 795
ELLW APEL+R +GG + +GDVFSF+II+QEVI R PY M+ EI+++
Sbjct: 768 CLPELLWVAPELLRNPVQGGSF----AGDVFSFSIIIQEVITRSLPYAMMDMPAHEIVER 823
Query: 796 LCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDS 855
L +PPPL RP VS+ AP E +S+M +CW+E P RP FN + FR + +G+K NI+DS
Sbjct: 824 LKKPPPLCRPLVSVDEAPTECLSLMNECWNEEPSKRPGFNDIFKQFRGINKGKKANIIDS 883
Query: 856 MFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEV 915
M MLE+YS+NLE+LIRERT++L++E+ KT++L+ ++LP+SVA+ L G V+PE + E
Sbjct: 884 MLRMLEQYSSNLEDLIRERTDELEVERTKTDKLVGQLLPKSVAQALKKGRPVQPEHYSES 943
Query: 916 SIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ 975
++YFSDIVGFT ++A S ++VVDLLNDLYT FDA I + VYKVETIGDAYMV G+P
Sbjct: 944 TLYFSDIVGFTTISALSEPIEVVDLLNDLYTMFDAIIATHDVYKVETIGDAYMVASGVPN 1003
Query: 976 RTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLF 1034
R + HA VA M+L +LH F+++H+P+ + +RIGLH+GP AGVVGLTMPRYCLF
Sbjct: 1004 RNGNRHAAEVANMSLDILHSIAAFKIKHMPEIKVKIRIGLHSGPVVAGVVGLTMPRYCLF 1063
Query: 1035 GDTVNTASRMESTGAAWRIQISSTTAEKLLAAG-GYKLRSRGLTQIKGKGAMHTYWLLGK 1093
GDTV TAS ME++G +RI IS +T + L + GY + +R + + KGA+ TYWL+G+
Sbjct: 1064 GDTVTTASHMEASGLPYRIHISLSTVKVLTSLKLGYHMETR---KAQVKGAVDTYWLVGR 1120
Query: 1094 EGFD 1097
+GFD
Sbjct: 1121 DGFD 1124
>UniRef50_UPI00015B6146 Cluster: PREDICTED: similar to
ENSANGP00000009149; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000009149 - Nasonia
vitripennis
Length = 1329
Score = 470 bits (1159), Expect = e-130
Identities = 248/507 (48%), Positives = 328/507 (64%), Gaps = 13/507 (2%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRP--ALVFDECW 656
YKG ++ ++ ++E+ R+ L +M++LR +N+N FIG C P +V + C
Sbjct: 575 YKGRIFAVKKVKKK-SIEITREMKKELKIMRDLRHDNLNAFIGA-CTDPPNICIVVEYCA 632
Query: 657 RGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRV 716
RGSL+D+L +DIKLD F SL+ D+V+GM YLH S ++ HG L++ NC+VDSRWV+++
Sbjct: 633 RGSLKDILENEDIKLDNMFMASLVGDIVRGMIYLHESVVKFHGSLTTSNCLVDSRWVVKL 692
Query: 717 TDYGLPALHRTQGLPPAQRTPRE------LLWTAPELIREAREGGGWLATQSGDVFSFAI 770
D+GL R L PA + LL+ APEL+R Q GDV+SFAI
Sbjct: 693 ADFGLHEFKRDAELEPADVMKKSSMGIAGLLYKAPELLRPRAVEPTIRDFQKGDVYSFAI 752
Query: 771 IMQEVIVRGEPYCMLSFTPEEIIDKLC--RPPPLIRPSVSMGAAPPEAVSVMRQCWSEAP 828
++ E+ R PY + + +I+ ++ PP P + + +CW+E P
Sbjct: 753 VLYELQGRHGPYGITELSAPDILKRVITVENPPFRPPLDQLENCFDFVRDCLLECWAENP 812
Query: 829 DLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQL 888
D RPDF + + R +++G K NI D+M M+EKY+NNLE L+ ERT+QL EKKKT+ L
Sbjct: 813 DFRPDFKVIRNKLRPLRKGMKPNIFDNMMAMMEKYANNLEALVDERTDQLSEEKKKTDAL 872
Query: 889 LNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTF 948
L MLPR VAE+L G +VE E F+ V+IYFSDIVGFTA++A ST +QVVD LNDLYT F
Sbjct: 873 LYEMLPRYVAEQLKRGHKVEAENFDCVTIYFSDIVGFTAMSAESTPLQVVDFLNDLYTCF 932
Query: 949 DAAIEQYRVYKVETIGDAYMVVGGLPQRTR-DHAESVATMALHLLHLAGRFRVRHLPDTP 1007
D+ IE Y VYKVETIGDAYMVV GLP R HA +A+M+LHLL +F +RH P
Sbjct: 933 DSTIENYDVYKVETIGDAYMVVSGLPIRNGIQHAGEIASMSLHLLDAIKQFSIRHRPLDK 992
Query: 1008 LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAG 1067
L LRIG+H+GP CAGVVGL MPRYCLFGDTVNTASRMESTG+ RI S+ T + L G
Sbjct: 993 LQLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGSPLRIHCSTETKQLLDQLG 1052
Query: 1068 GYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
G+ L RGL +KGKG TYWL+G+E
Sbjct: 1053 GFSLAERGLVSMKGKGERLTYWLIGEE 1079
>UniRef50_P16065 Cluster: Speract receptor precursor; n=7;
Euechinoidea|Rep: Speract receptor precursor -
Strongylocentrotus purpuratus (Purple sea urchin)
Length = 1125
Score = 469 bits (1157), Expect = e-130
Identities = 254/503 (50%), Positives = 335/503 (66%), Gaps = 21/503 (4%)
Query: 603 AVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRP--ALVFDECWRGSL 660
AVH H+ +T + + K +M+++R +N+ PFIG C RP +++ C +GSL
Sbjct: 601 AVHKNHIDLTRAVRTELK------IMRDMRHDNICPFIGA-CIDRPHISILMHYCAKGSL 653
Query: 661 EDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYG 720
+D+L DDIKLD F SL++DLVKG+ YLH S +++HG L S NCVVD+RWVL++TDYG
Sbjct: 654 QDILENDDIKLDSMFLSSLIADLVKGIVYLHSSEIKSHGHLKSSNCVVDNRWVLQITDYG 713
Query: 721 LPALHRTQ----GLPPAQRTPRELLWTAPELIREAREGGGWLA-TQSGDVFSFAIIMQEV 775
L + Q L + R+L WT+PE +R+ EG A + GD++SFAII+ E+
Sbjct: 714 LNEFKKGQKQDVDLGDHAKLARQL-WTSPEHLRQ--EGSMPTAGSPQGDIYSFAIILTEL 770
Query: 776 IVRGEPYCMLSFTPEEIIDKL-CRPPPLIRPSVS-MGAAPPEAV-SVMRQCWSEAPDLRP 832
R EP+ +II ++ P RP ++ + AA P+ V S +R CW E P RP
Sbjct: 771 YSRQEPFHENEMDLADIIGRVKSGEVPPYRPILNAVNAAAPDCVLSAIRACWPEDPADRP 830
Query: 833 DFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRM 892
+ + + +Q+G K NI+D+M ++E+Y+NNLEEL+ ERT++L EK KTEQLL+RM
Sbjct: 831 NIMAVRTMLAPLQKGLKPNILDNMIAIMERYTNNLEELVDERTQELQKEKTKTEQLLHRM 890
Query: 893 LPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAI 952
LP S+A +L+ G V PE FE VSI+FSDIVGFTAL+A ST +QVV+LLNDLYT FDA I
Sbjct: 891 LPPSIASQLIKGIAVLPETFEMVSIFFSDIVGFTALSAASTPIQVVNLLNDLYTLFDAII 950
Query: 953 EQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLR 1011
Y VYKVETIGDAYM+V GLP R D HA +A+ A HLL F V H P+ L LR
Sbjct: 951 SNYDVYKVETIGDAYMLVSGLPLRNGDRHAGQIASTAHHLLESVKGFIVPHKPEVFLKLR 1010
Query: 1012 IGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKL 1071
IG+H+G C AGVVGLTMPRYCLFGDTVNTASRMES G A RI +S + L GGY+L
Sbjct: 1011 IGIHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGLALRIHVSPWCKQVLDKLGGYEL 1070
Query: 1072 RSRGLTQIKGKGAMHTYWLLGKE 1094
RGL + GKG +HT+WLLG++
Sbjct: 1071 EDRGLVPMNGKGEIHTFWLLGQD 1093
>UniRef50_P16066 Cluster: Atrial natriuretic peptide receptor A
precursor; n=57; Chordata|Rep: Atrial natriuretic peptide
receptor A precursor - Homo sapiens (Human)
Length = 1061
Score = 468 bits (1154), Expect = e-130
Identities = 250/505 (49%), Positives = 333/505 (65%), Gaps = 15/505 (2%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRP--ALVFDECW 656
YKG+ V ++ + +EL RK L M++++ E++ F+G C P ++ + C
Sbjct: 559 YKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGA-CTDPPNICILTEYCP 616
Query: 657 RGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRV 716
RGSL+D+L + I LDW FR SL +D+VKGM +LH + +HG L S NCVVD R+VL++
Sbjct: 617 RGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKI 676
Query: 717 TDYGLPALHRTQGLPPAQ--RTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQE 774
TDYGL + + L P Q + LWTAPEL+R A +Q+GDV+SF II+QE
Sbjct: 677 TDYGLESF---RDLDPEQGHTVYAKKLWTAPELLRMASPPVR--GSQAGDVYSFGIILQE 731
Query: 775 VIVRGEPYCM--LSFTPEEIIDKLCR-PPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLR 831
+ +R + + L +P+EII+++ R P RPS+++ + E +M++CW+E P R
Sbjct: 732 IALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQER 791
Query: 832 PDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNR 891
P F ++ R+ R NI+D++ +E+Y+NNLEEL+ ERT+ EK+K E LL +
Sbjct: 792 PPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQ 851
Query: 892 MLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAA 951
+LP SVAE+L G V+ E F+ V+IYFSDIVGFTAL+A ST +QVV LLNDLYT FDA
Sbjct: 852 ILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAV 911
Query: 952 IEQYRVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHL 1010
I+ + VYKVETIGDAYMVV GLP R R HA VA MAL LL FR+RH P L L
Sbjct: 912 IDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRL 971
Query: 1011 RIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYK 1070
RIG+HTGP CAGVVGL MPRYCLFGDTVNTASRMES G A +I +SS T L GG++
Sbjct: 972 RIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFE 1031
Query: 1071 LRSRGLTQIKGKGAMHTYWLLGKEG 1095
L RG ++KGKG + TYWLLG+ G
Sbjct: 1032 LELRGDVEMKGKGKVRTYWLLGERG 1056
>UniRef50_Q8IQK2 Cluster: Guanylate cyclase; n=6; Diptera|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 1272
Score = 468 bits (1153), Expect = e-130
Identities = 240/510 (47%), Positives = 335/510 (65%), Gaps = 19/510 (3%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRP--ALVFDECW 656
YKG ++ ++ ++++ R+ L L+++ R +N+ FIG C P ++ + C
Sbjct: 619 YKGQLYAIKKVRKK-SVDITREMKKELKLLRDARHDNICAFIGA-CTDPPNICIISEYCT 676
Query: 657 RGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRV 716
RGSL+D+L +D+KLD F S+++D+++G+ YLH SP+R HG L + NC+VDSRWV+++
Sbjct: 677 RGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKL 736
Query: 717 TDYGLPALHRTQGLPPAQRTPR-------ELLWTAPELIREAREGGGWLATQSGDVFSFA 769
TD+GL A QG+ + + +LL+ APEL+R+ + TQ GD +SF
Sbjct: 737 TDFGLFAFK--QGIEDSSTDMQHMSAKCLKLLYRAPELLRQG-PSSLVMGTQRGDAYSFG 793
Query: 770 IIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLI---RPSVSMGAAPPEAVS-VMRQCWS 825
I++ E+ VR P+ TP + + K+ +P + RPS+ + VS +R+CW+
Sbjct: 794 ILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWA 853
Query: 826 EAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKT 885
E P+ RPDF + R +++G + NI D+M M+EKY+NNLE L+ +RT+QL EKKKT
Sbjct: 854 ERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKT 913
Query: 886 EQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLY 945
+ LL+ MLPR VA++L G +V+PE +E+VSIYFSDIVGFTA++A T +QVVD LNDLY
Sbjct: 914 DALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLY 973
Query: 946 TTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLP 1004
T FD+ I Y VYKVETIGDAYMVV GLP R D HA +ATM+LHLL F++RH P
Sbjct: 974 TCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRP 1033
Query: 1005 DTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLL 1064
L LRIG+H+GP CAGVVGL MPRYCLFGDTVNTASRMES+G +I S + L
Sbjct: 1034 TNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLD 1093
Query: 1065 AAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
GGY RG+ +KGKG TYWLLG++
Sbjct: 1094 RLGGYHFAERGVISMKGKGDQRTYWLLGED 1123
>UniRef50_Q8TA72 Cluster: Guanylate cyclase; n=2; Eumetazoa|Rep:
Guanylate cyclase - Asterias amurensis (Starfish)
Length = 1067
Score = 467 bits (1152), Expect = e-130
Identities = 249/505 (49%), Positives = 330/505 (65%), Gaps = 12/505 (2%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEG-RPALVFDECWR 657
Y+G+ ++ + +++L R L M ++R +NV F+G + ++ C +
Sbjct: 551 YRGNICAIKAVN-KHSIDLTRTVRQELKAMHDVRHDNVCQFVGASVDSPHVCILMTYCAK 609
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
GSL+D+L DDIKLD F S+++DLVKGM Y+H S + +HG L S NCVVD+R+VL++T
Sbjct: 610 GSLQDILENDDIKLDNMFLASMIADLVKGMIYIHTSMIESHGNLKSSNCVVDNRFVLQIT 669
Query: 718 DYGLPALHRTQG----LPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQ 773
DYGL + QG LP R R LLW APEL+R ++ T GDV+SFA+++
Sbjct: 670 DYGLHEFKKGQGEDPDLPDDVRY-RNLLWRAPELLRMGKKMP-LAGTPKGDVYSFAVVLT 727
Query: 774 EVIVRGEPYCMLSFTPEEIIDKLCRPP-PLIRPSVS-MGAAPPEAV-SVMRQCWSEAPDL 830
E+ R EPY + PEEI++K+ P RP ++ + PE V +R CW E P
Sbjct: 728 EMYSRAEPYNLNDDEPEEIVEKVMAGSIPPYRPLLNDVNEKAPECVLKAIRSCWGEDPVE 787
Query: 831 RPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLN 890
RPDF + + +Q+G K NI+D+M ++E+Y+NNLEEL+ ERT++L EK KTEQLL+
Sbjct: 788 RPDFFKARTMLAPLQKGLKPNIMDNMITIMERYTNNLEELVDERTQELQKEKAKTEQLLH 847
Query: 891 RMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDA 950
RMLP S+A +L+ G V PE F+ V+I+FSDIVGFTAL+A ST +QVV+LLN LYTTFDA
Sbjct: 848 RMLPPSIASQLIKGISVAPEAFDMVTIFFSDIVGFTALSAASTPIQVVNLLNALYTTFDA 907
Query: 951 AIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLH 1009
I Y VYKVETIGDAYM+V GLP R + HA +A+ A HLL F V H D L
Sbjct: 908 TISNYDVYKVETIGDAYMLVSGLPLRNGNRHAGMIASAAWHLLEEVTTFVVPHKRDEKLK 967
Query: 1010 LRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGY 1069
LRIG+H+G C AGVVGLTMPRYCLFGDTVNTASRMES G A +I +S + L GGY
Sbjct: 968 LRIGIHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGLALKIHVSPECRQVLQELGGY 1027
Query: 1070 KLRSRGLTQIKGKGAMHTYWLLGKE 1094
L RGL +KGKG + TYWL G++
Sbjct: 1028 NLVERGLVAMKGKGEILTYWLEGQD 1052
>UniRef50_UPI00015B6145 Cluster: PREDICTED: similar to guanylate
cyclase; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to guanylate cyclase - Nasonia vitripennis
Length = 1542
Score = 461 bits (1136), Expect = e-128
Identities = 250/509 (49%), Positives = 327/509 (64%), Gaps = 18/509 (3%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVFDECWR 657
Y G V ++ L+ + ++ R + +++ +R N+N FIG C+ R L+ D C +
Sbjct: 643 YHGVVVRIKELKFSKKKDISRDVMKEMRILREIRHGNLNSFIGACVEPMRILLITDYCAK 702
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLH-GSPLRAHGRLSSRNCVVDSRWVLRV 716
GSL D++ +DIKLD F SL+ DL+KGM Y+H S L HG L S NCVV SRWVL+V
Sbjct: 703 GSLYDIIENEDIKLDDMFIASLIHDLIKGMLYIHESSVLVCHGNLKSSNCVVTSRWVLQV 762
Query: 717 TDYGLPAL-HRTQGLPPAQRTP-RELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQE 774
+D+GL + H + + R L W APEL+R TQ GD++SFAII+ E
Sbjct: 763 SDFGLHDMRHCAESDSIGEHQYYRNLFWKAPELLRNLH--APIRGTQEGDIYSFAIILFE 820
Query: 775 VIVRGEPYCMLSFTPEEIIDKLCRPP----PLIRPSVSMGAAPPEA------VSVMRQCW 824
+I R PY ++ P+EIID++ R P P RP+V + + EA V+ + CW
Sbjct: 821 IIGRKGPYGGVNLEPKEIIDRVKRYPEDGEPPFRPNVDI-LSESEADCADYIVNTITDCW 879
Query: 825 SEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKK 884
+E+P+LRPDF + ++M+ G+ NI+D M +M+EKY+NNLE+L+ ERT L EK+K
Sbjct: 880 AESPELRPDFKTIRTRLKKMKAGKHRNIMDQMMDMMEKYANNLEDLVSERTRLLFEEKQK 939
Query: 885 TEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDL 944
TE LL+RMLP VA L G VEPE F+ V+IYFSDIVGFTA++A ST QVV+ LNDL
Sbjct: 940 TEDLLHRMLPEPVANCLTNGIGVEPEAFDLVTIYFSDIVGFTAMSAESTPFQVVNFLNDL 999
Query: 945 YTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHL 1003
YT FD I+ Y VYKVETIGDAYMVV GLP + + HA +A+M+L LL+ + H
Sbjct: 1000 YTLFDRIIKGYDVYKVETIGDAYMVVSGLPIKNGNRHAGEIASMSLELLNAVKHHTIAHR 1059
Query: 1004 PDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKL 1063
P L LRIG+HTGP AGVVGLTMPRYCLFGDTVNTASRMES G RI IS+ + L
Sbjct: 1060 PSETLKLRIGIHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEPLRIHISAQCKDAL 1119
Query: 1064 LAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
GGY + RGL Q+KGKG + TYWL G
Sbjct: 1120 DKIGGYVIEERGLVQMKGKGEVKTYWLTG 1148
>UniRef50_O97053 Cluster: Guanylate cyclase; n=1; Stichopus
japonicus|Rep: Guanylate cyclase - Stichopus japonicus
(Sea cucumber)
Length = 1075
Score = 457 bits (1127), Expect = e-127
Identities = 242/522 (46%), Positives = 337/522 (64%), Gaps = 16/522 (3%)
Query: 584 STCSVNRVVVDRRIRYKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCL 643
S C N+ + YKG+ V ++ L+ ++L R+ + +M+ ++ ++V F+GC
Sbjct: 541 SICGHNQQIFTVTGYYKGNVVAIKKLE-RDRIDLTRQVLMEMKVMREIQHDHVTKFVGC- 598
Query: 644 CEGRP--ALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRL 701
C P +++ + C +GSL+D+L D I+LD F+ SLL DLVKGM Y+H S + +HG L
Sbjct: 599 CGDAPNISILTEYCPKGSLQDILENDSIELDEMFKFSLLYDLVKGMHYIHSSMIHSHGNL 658
Query: 702 SSRNCVVDSRWVLRVTDYGLPALHRT-----QGLPPAQRTPRELLWTAPELIREAREGGG 756
S NCVVD+R+VL+VTD+GL + + + + R + LWTAPEL+R G
Sbjct: 659 KSSNCVVDNRFVLKVTDFGLNTVRQPDHPLDKETEDSYRYYHKRLWTAPELLRLPEIPSG 718
Query: 757 WLATQSGDVFSFAIIMQEVIVRGEPYCM--LSFTPEEIIDKLCRPPPL-IRPSVSMGAAP 813
GDV+S II+QE+++R + + +PEEII K+ + RP V+ P
Sbjct: 719 --GHPKGDVYSLGIIIQEIMLREGVFYFGEMDLSPEEIIQKVRQGTTTPFRPVVTRDQMP 776
Query: 814 PEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKI-NIVDSMFEMLEKYSNNLEELIR 872
E + +M +CW+E P +RPDF+ + R++ +GR+ N+VD++ +E+Y++NLE+L+
Sbjct: 777 EEVMDMMNKCWAEDPPMRPDFSHIRTSVRKLNKGRETGNLVDNLLSRMEQYASNLEDLVE 836
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARS 932
ERTE EKKK E+LL ++LP+ VAE L G V E FE V+IYFSDIVGFT L+++S
Sbjct: 837 ERTEAFYEEKKKAEELLYQILPKPVAEELKKGKPVTAETFEVVTIYFSDIVGFTKLSSQS 896
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHL 991
T +QVVDLLNDLYT FDA I+ + VYKVETIGDAYMVV GLP R D HA +A M+L L
Sbjct: 897 TPLQVVDLLNDLYTAFDAVIDNFNVYKVETIGDAYMVVSGLPIRNGDYHAREIARMSLAL 956
Query: 992 LHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAW 1051
L FR+RH + L LRIG+H+GP AGVVGL MPRYCLFGDTVNTASRMES G A
Sbjct: 957 LQRIKTFRIRHRSEERLKLRIGIHSGPAVAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 1016
Query: 1052 RIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
+I +SS+T + L G + L RG ++KGKG TYWL G+
Sbjct: 1017 KIHVSSSTKKILDLFGTFVLEKRGEIEMKGKGVQTTYWLQGE 1058
>UniRef50_UPI0000F2B0A8 Cluster: PREDICTED: similar to guanylyl
cyclase-G; n=6; Euteleostomi|Rep: PREDICTED: similar to
guanylyl cyclase-G - Monodelphis domestica
Length = 1111
Score = 454 bits (1119), Expect = e-126
Identities = 241/511 (47%), Positives = 322/511 (63%), Gaps = 18/511 (3%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKST-DVLLLMQNLRQENVNPFIGCLCEGRP--ALVFDEC 655
Y+G+ V ++H++ + S + LM L+ EN+ PF G +C P LV C
Sbjct: 552 YQGNHVAIKHMENGKESCFSKPSVLREIQLMCELKHENLVPFFG-ICTESPNICLVIQYC 610
Query: 656 WRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLR 715
+GSL+D+L DI+LDW F+LS D+V GM +LH SPL +HG L C+VDSR ++
Sbjct: 611 RKGSLKDILRNSDIELDWVFKLSFAYDIVNGMLFLHKSPLNSHGNLKPSKCLVDSRMQVK 670
Query: 716 VTDYGLPALHRTQGLPPAQRTPR-----ELLWTAPELIREAREGGGWLATQSGDVFSFAI 770
++ +GL L QG R + E WTAPEL+R E TQ GD++SFAI
Sbjct: 671 LSGFGLWELK--QGRKSRSRGEKNTDYSEFYWTAPELLR--LEEPPTCGTQKGDIYSFAI 726
Query: 771 IMQEVIVRGE--PYCMLSFTPEEIIDKLCRPPPLI--RPSVSMGAAPPEAVSVMRQCWSE 826
+M+E+I + P+ L+ EEII+K+ P + RP++ + ++++R CW E
Sbjct: 727 LMKELIYNDQCGPFGDLNKEAEEIINKIKDPTAAVPLRPNLLREKCNEKVIAMLRNCWDE 786
Query: 827 APDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTE 886
+P+ RP F+++ R+ ++I+DSM LEKY+N+LEE++ ERT QL EKKK
Sbjct: 787 SPEKRPTFSQVKRTLREASPEGHVSILDSMVNKLEKYANHLEEVVEERTTQLMSEKKKIH 846
Query: 887 QLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYT 946
LL+ MLP + E+LM G VEPE+F+ V+I+FSDIVGFT L + ST +QVV LLNDLY+
Sbjct: 847 TLLSTMLPSFIGEQLMAGRSVEPEQFDSVTIFFSDIVGFTKLCSLSTPLQVVGLLNDLYS 906
Query: 947 TFDAAIEQYRVYKVETIGDAYMVVGGLPQRTR-DHAESVATMALHLLHLAGRFRVRHLPD 1005
FD I+ Y VYKVETIGDAYMV GLP R H E +ATM+LH L + F++ H P+
Sbjct: 907 LFDNIIKTYDVYKVETIGDAYMVASGLPLRNGIQHVEEIATMSLHFLSVVVHFKIGHKPE 966
Query: 1006 TPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLA 1065
L LRIGLHTGP AGVVG+TMPRYCLFGDTVN ASRMES RI +S TTA L +
Sbjct: 967 EKLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESNSLPLRIHVSQTTASALRS 1026
Query: 1066 AGGYKLRSRGLTQIKGKGAMHTYWLLGKEGF 1096
GGY L+ RG ++KGKG TYWL GK GF
Sbjct: 1027 VGGYVLQERGTIKVKGKGEQTTYWLKGKVGF 1057
>UniRef50_Q6TL19 Cluster: Guanylate cyclase 2G precursor; n=6;
Murinae|Rep: Guanylate cyclase 2G precursor - Mus
musculus (Mouse)
Length = 1100
Score = 453 bits (1117), Expect = e-125
Identities = 242/509 (47%), Positives = 327/509 (64%), Gaps = 14/509 (2%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTD-VLLLMQNLRQENVNPFIGCLCEGRP--ALVFDEC 655
Y+G+ V L ++ +K+ + + LM L+ EN+ PF G +C P +V C
Sbjct: 577 YQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHENIVPFFG-VCTEPPNICIVTQYC 635
Query: 656 WRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLR 715
+GSL+DV+ D ++DW F+LS D+V G+ +LHGSPLR+HG L NC+VDS L+
Sbjct: 636 KKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLK 695
Query: 716 VTDYGLPAL-HRTQGLPPAQRTP--RELLWTAPELIREAREGGGWLATQSGDVFSFAIIM 772
++ +GL H + Q EL WTAPEL+R RE T GDV+SFAI++
Sbjct: 696 LSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPELLR-LRESP-CSGTPQGDVYSFAILL 753
Query: 773 QEVIVRGE--PYCMLSFTPEEIIDKLCRP--PPLIRPSVSMGAAPPEAVSVMRQCWSEAP 828
+++I + P+ L PEEII ++ P P +RPS+ V+++R+CW E+P
Sbjct: 754 RDLIHQQAHGPFEDLEAAPEEIISRIKDPRAPVPLRPSLLEDKGDGRIVALVRECWDESP 813
Query: 829 DLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQL 888
+LRP F + R+ ++I+DSM LE Y+N+LEE++ ERT +L EK+K E+L
Sbjct: 814 ELRPIFPSIKKTLREASPRGHVSILDSMMGKLETYANHLEEVVEERTRELVAEKRKVEKL 873
Query: 889 LNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTF 948
L+ MLP V E+L+ G VEPE FE V+I+FSDIVGFT L + S+ +QVV LLNDLY+ F
Sbjct: 874 LSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLF 933
Query: 949 DAAIEQYRVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTP 1007
D I+ + VYKVETIGDAYMV GLP R HA+ +ATMALHLL + F++ H+P+
Sbjct: 934 DHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEER 993
Query: 1008 LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAG 1067
L LRIGLHTGP AGVVG+TMPRYCLFGDTVN ASRMES+ RI +S +TA LLAAG
Sbjct: 994 LKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAG 1053
Query: 1068 GYKLRSRGLTQIKGKGAMHTYWLLGKEGF 1096
GY L+ RG +KGKG T+WL GK+GF
Sbjct: 1054 GYHLQKRGTISVKGKGEQTTFWLKGKDGF 1082
>UniRef50_UPI0000E45ED9 Cluster: PREDICTED: similar to
ENSANGP00000009149; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to ENSANGP00000009149
- Strongylocentrotus purpuratus
Length = 1268
Score = 449 bits (1107), Expect = e-124
Identities = 242/502 (48%), Positives = 328/502 (65%), Gaps = 28/502 (5%)
Query: 604 VHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRP--ALVFDECWRGSLE 661
VH +H++++ L RK L +M+++ N+ FIG C P ++ + C RGSL+
Sbjct: 574 VHKKHIEMSRCL---RKE---LKVMRDMCHPNLCQFIGA-CPDPPNICILTEYCTRGSLQ 626
Query: 662 DVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGL 721
D+L DDIKLD F SL+SD+VKGMR+LH + +R HG L S NCVVDSRWVL++TD+GL
Sbjct: 627 DILENDDIKLDEMFIASLVSDIVKGMRHLHSTEIRTHGNLKSSNCVVDSRWVLKITDFGL 686
Query: 722 PALHRTQGLPPAQRTP----RELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIV 777
+H G P ++LLW APE+ TQ GDV+SF II+ E+
Sbjct: 687 --VHFKVGQQPPDMGEHAYYQDLLWKAPEVWEPQ-------GTQKGDVYSFGIILYEIAH 737
Query: 778 RGEPYCMLSFTPEEIIDK---LCRPPPLIRPSVSMGAAPPEAV-SVMRQCWSEAPDLRPD 833
R P+ +P+EI +K L PL RP+V E + +VM++CW E P+ RPD
Sbjct: 738 RQGPFGNCELSPKEIYEKVKTLGETIPL-RPNVMEIENGHECLLTVMQECWVEDPEARPD 796
Query: 834 FNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRML 893
F + + + + +G K +I+D+M ++EKY+NNLEE++ +RT+QL EKKKTE LL+RML
Sbjct: 797 FKTIANKLKPLHKGMKSDILDNMVMIMEKYANNLEEIVEDRTQQLVEEKKKTENLLHRML 856
Query: 894 PRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIE 953
P+ VA +L G +V PE F+ V+I+FSDIVGFT L++ ST QVVDLLNDLYT FD I
Sbjct: 857 PKPVANQLKRGMQVVPESFDCVTIFFSDIVGFTKLSSMSTPFQVVDLLNDLYTLFDDIIS 916
Query: 954 QYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRI 1012
Y VYKVETIGDAYM+V GLP R + HA + + ALHL+ +F++RH PD L LR+
Sbjct: 917 YYNVYKVETIGDAYMLVSGLPIRNDNRHAAEIGSTALHLIDEVQKFKIRHRPDDTLKLRV 976
Query: 1013 GLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLR 1072
G+H+GP GVVGLTMPRYCLFGDTVNT+SRMES G A +I S+ L GGY +
Sbjct: 977 GIHSGPVVTGVVGLTMPRYCLFGDTVNTSSRMESNGEALKIHCSAECKAILDEVGGYDVP 1036
Query: 1073 SRGLTQIKGKGAMHTYWLLGKE 1094
RG+ +KGKG++ TYWL+ ++
Sbjct: 1037 ERGIVAMKGKGSLLTYWLVDQD 1058
>UniRef50_UPI00015B48AF Cluster: PREDICTED: similar to
ENSANGP00000014144; n=2; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000014144 - Nasonia
vitripennis
Length = 1648
Score = 447 bits (1102), Expect = e-124
Identities = 229/501 (45%), Positives = 325/501 (64%), Gaps = 24/501 (4%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVF--DEC 655
YKG+ V ++ + +++ +K + ++++ EN FIG CLC P ++ + C
Sbjct: 1113 YKGERVAIKKVTKKKVVDVTKKLLWEIKQVRDVTSENTVRFIGACLCSPSPTVLILTEYC 1172
Query: 656 WRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLR 715
+GSL+DVL + IKLDW FR+SL+ D+ KGM YLH S + AHG+L S NC++D R+VL+
Sbjct: 1173 PKGSLKDVLENEAIKLDWNFRMSLIHDIAKGMAYLHASDVSAHGKLRSCNCLIDGRFVLK 1232
Query: 716 VTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEV 775
++D+GL L TP +LL +ATQ GDV+SFAII++E+
Sbjct: 1233 ISDFGLKTL----------TTPSDLLMDETYYTSS-------VATQKGDVYSFAIILEEI 1275
Query: 776 IVRGEPY--CMLSFTPEEIIDKLCRPP-PLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRP 832
++RG PY + +EI++++ P RP V+ P + +S+M +CW+E P+ RP
Sbjct: 1276 VIRGGPYEVARTYMSSQEIVNRVAASESPPFRPEVAQKEYPADILSLMEKCWNEVPEERP 1335
Query: 833 DFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRM 892
F+ + R + +G N++D + +E+Y+NNLE L+ E+TEQL +EK+++E+LL ++
Sbjct: 1336 TFHAVRGTIRGIMKGYCENLMDDLLRRMEQYANNLEALVEEKTEQLSLEKRRSEELLYQV 1395
Query: 893 LPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAI 952
LPR VA +LM G V+PE+FE V+IYFSDIVGFTAL A+ST ++VVD LNDLY+TFD I
Sbjct: 1396 LPRQVACQLMAGEMVQPEQFECVTIYFSDIVGFTALCAKSTPMEVVDFLNDLYSTFDRII 1455
Query: 953 EQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLR 1011
Y VYKVETIGDAYMVV GLP+R D H++ +A MAL +L F + H D L +R
Sbjct: 1456 GFYDVYKVETIGDAYMVVSGLPERNGDEHSKEIALMALAILDAVKSFTIIHKQDAQLSVR 1515
Query: 1012 IGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKL 1071
IG+H+GP CAGVVG MP YCLFGDTVNTASRMES+G RI +S T + L G + L
Sbjct: 1516 IGVHSGPVCAGVVGQKMPHYCLFGDTVNTASRMESSGLPLRIHVSRATKDILDKYGTFDL 1575
Query: 1072 RSRGLTQIKGKGAMHTYWLLG 1092
RG ++KGKG + T+WL G
Sbjct: 1576 ELRGDVELKGKGKVTTFWLTG 1596
>UniRef50_Q9VF17 Cluster: Guanylate cyclase; n=7; Endopterygota|Rep:
Guanylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 1417
Score = 447 bits (1101), Expect = e-123
Identities = 243/516 (47%), Positives = 329/516 (63%), Gaps = 22/516 (4%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDV-LLLMQNLRQENVNPFIG-CLCEGRPALVFDECW 656
++ V ++ ++V L +S + L M++L+ +++ F G CL + R L+ + C
Sbjct: 617 FRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCP 676
Query: 657 RGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRV 716
+GSL+D+L + +LDW FRLSL+ D+V+GM++LH S +R+HG L S NCVVDSR+VL++
Sbjct: 677 KGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKI 736
Query: 717 TDYGLPALHRTQ-------GLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFA 769
TD+GL L RT+ G + +LLWTAPEL+R TQ GDV++F
Sbjct: 737 TDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLR-VEHNRPPEGTQKGDVYAFG 795
Query: 770 IIMQEVIVRGEPY----CMLSFTPEEIID--KLCRPPPL---IRPSVSM-GAAPPEAVSV 819
II+ E+ R P+ C +P+EII+ K P + RP + G + +
Sbjct: 796 IIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGI 855
Query: 820 MRQCWSEAPDLRPDFNRLHDVFRQMQRGRKI-NIVDSMFEMLEKYSNNLEELIRERTEQL 878
+R+CW+E P RPDFN L + R+ + + NIVD++ + +E Y+NNLEEL+ ERT+
Sbjct: 856 IRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDY 915
Query: 879 DMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVV 938
EKKK E+LL ++LP+SVA +L+ G V E F++V+IYFSDIVGFTA++A ST +QVV
Sbjct: 916 HEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVV 975
Query: 939 DLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGR 997
LNDLYT FD+ +E + VYKVETIGDAYMVV GLP R HA +A +AL LL
Sbjct: 976 QFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHN 1035
Query: 998 FRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISS 1057
FR+ H P+ L LRIGLHTG C AGVVGL MPRYCLFGDTVNTASRMES G A +I IS
Sbjct: 1036 FRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISE 1095
Query: 1058 TTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
TT E L G + RG +KGKG M TYWL G+
Sbjct: 1096 TTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
>UniRef50_Q17AF9 Cluster: Guanylate cyclase; n=1; Aedes aegypti|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 987
Score = 446 bits (1100), Expect = e-123
Identities = 235/497 (47%), Positives = 311/497 (62%), Gaps = 8/497 (1%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCE-GRPALVFDECWR 657
Y+G+ V + +L ++++ R L M+ LR EN+ FIG + G A++ C R
Sbjct: 494 YRGNIVAINYLHKR-SVDITRTIRKELKQMRKLRHENLITFIGASVDHGVVAILTSYCAR 552
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
GSL DVL +D+ LD F SL+SD+VKG+ YLH S + +HG L S ++DSRWV +++
Sbjct: 553 GSLADVLANEDLSLDHMFVSSLVSDIVKGLIYLHDSDVGSHGNLRSSKILIDSRWVAQIS 612
Query: 718 DYGLPALHRTQGLPPA-QRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVI 776
D+GL Q P ++ LW APE++R TQ GDV+SF I++ E++
Sbjct: 613 DFGLHEFKSGQDEPNKFEKELHRSLWKAPEILRNPNTPSR--GTQKGDVYSFGIVLYEIV 670
Query: 777 VRGEPYCMLSFTPEEIIDKLCRPPP--LIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDF 834
P+ ++ +EII ++ P + RP + A + ++ CW E PD RPD
Sbjct: 671 GMKGPWGEINLNYQEIIARVISPQNYGIFRPPLRGLEASDYVIQCLQACWEEEPDDRPDI 730
Query: 835 NRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLP 894
+ + MQ G K NI D+M ++EKY+ NLE +++ERT QL EKKKTE LL RMLP
Sbjct: 731 RLVRVKLKPMQAGLKPNIFDNMLAIMEKYAYNLEGIVQERTNQLTEEKKKTESLLLRMLP 790
Query: 895 RSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQ 954
RSVAE LM G RVE E F+ V+I+FSD+VGFT L A+S +VV++LNDLYT D I
Sbjct: 791 RSVAESLMRGERVEAENFDCVTIFFSDLVGFTELCAQSNPFEVVEMLNDLYTCCDFIISS 850
Query: 955 YRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIG 1013
Y VYKVETIGDAYMVV GLP R D HA +A++ALHLL+ +RH P + +RIG
Sbjct: 851 YDVYKVETIGDAYMVVSGLPIRNGDRHAGEIASLALHLLNSLSNLEIRHRPGEFIQIRIG 910
Query: 1014 LHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRS 1073
+H+G C AGVVGL MPRYCLFGDTVNTASRMESTG A +I ISS T L GGY+
Sbjct: 911 IHSGQCVAGVVGLKMPRYCLFGDTVNTASRMESTGDAMKIHISSVTYNLLKKIGGYRFEE 970
Query: 1074 RGLTQIKGKGAMHTYWL 1090
RG+ +KGKG M TYWL
Sbjct: 971 RGVINVKGKGDMRTYWL 987
>UniRef50_UPI0000E4745B Cluster: PREDICTED: similar to
ENSANGP00000009149; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to ENSANGP00000009149
- Strongylocentrotus purpuratus
Length = 1319
Score = 446 bits (1098), Expect = e-123
Identities = 236/500 (47%), Positives = 324/500 (64%), Gaps = 18/500 (3%)
Query: 604 VHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVFDECWRGSLED 662
+H RH+ +T ++ RK L ++++LR ++N FIG C+ + + C +GSL+D
Sbjct: 651 IHKRHVDLTRSV---RKE---LKIIRDLRHPHLNQFIGACVDPPNICTITEYCPKGSLQD 704
Query: 663 VLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLP 722
+L D++KLD F SL+ D++KG+ LH S +HG L S N VVDSRWVL++TD+GL
Sbjct: 705 ILENDEVKLDSMFIASLIGDILKGLSCLHASETHSHGNLKSSNLVVDSRWVLKITDFGLH 764
Query: 723 ALHRTQGLPPA---QRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIVRG 779
R+ PP +LLW APEL+R+ TQ GD++S II+ E+ R
Sbjct: 765 QF-RSGSRPPEIGEHAKYEKLLWRAPELLRDPAPRPE--GTQKGDMYSLGIILYEMATRQ 821
Query: 780 EPYCMLSFTPEEIIDKLCRP--PPL-IRPSV-SMGAAPPEAVSVMRQCWSEAPDLRPDFN 835
PY P+EI+DK+ P P RP+V + P ++ M++CW+E PD RP+
Sbjct: 822 GPYGKCVLGPKEIVDKVTHPLDPNTPFRPNVMEVDDCPNCMLTGMQECWNENPDERPEVK 881
Query: 836 RLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPR 895
L + +Q+G K NI+D+M ++EKY+NNLE+++ +RT QL EKKKT+ LL++MLP+
Sbjct: 882 TLTTRLKPLQKGMKPNILDNMIVIMEKYANNLEDIVEDRTHQLIEEKKKTDNLLHQMLPK 941
Query: 896 SVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQY 955
VA +L G +V PE FE V+I+FSDIVGFT+L++ ST +VVD+LNDLYT FD I Y
Sbjct: 942 PVANQLKRGMQVVPESFECVTIFFSDIVGFTSLSSESTPFEVVDMLNDLYTLFDEIISYY 1001
Query: 956 RVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGL 1014
VYKVETIGDAYM+V GLP R + HA +A+ +LHLL F+VRH P+ L LRIG+
Sbjct: 1002 DVYKVETIGDAYMLVSGLPLRNEKKHAAEIASTSLHLLEDVKAFKVRHRPEVNLKLRIGI 1061
Query: 1015 HTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSR 1074
H+G +GVVGLTMPRYCLFGDTVNTASRMES G A +I SS T L GG+ + R
Sbjct: 1062 HSGSTVSGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHTSSETKNLLEQMGGFVVEER 1121
Query: 1075 GLTQIKGKGAMHTYWLLGKE 1094
GL +KGKG + TYWL+ +
Sbjct: 1122 GLISMKGKGQLVTYWLISAD 1141
>UniRef50_Q174S2 Cluster: Guanylate cyclase; n=7; Coelomata|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1292
Score = 440 bits (1084), Expect = e-121
Identities = 238/508 (46%), Positives = 333/508 (65%), Gaps = 18/508 (3%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGR-PALVFDECW 656
YKG V ++ + + L L R L M++++ +++ F G CL P ++ + C
Sbjct: 688 YKGCKVAIKKININN-LNLNRTMMLELKRMKDIQHDHLVRFYGACLDPSPDPFILTEYCP 746
Query: 657 RGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRV 716
+GSL+D+L + IKLDW F++SL+ D+VKGM +LH + L +HG L S NCVVDSR+VL++
Sbjct: 747 KGSLQDILENETIKLDWMFKISLMHDIVKGMAFLHSTELHSHGSLKSSNCVVDSRFVLKI 806
Query: 717 TDYGLPALHRTQGLPPAQRTP--RELLWTAPELIREA-REGGGWLATQSGDVFSFAIIMQ 773
TD+GL L + + ++LLWTAPEL+R+ R+ G TQ GDV+SF II+
Sbjct: 807 TDFGLHQLRGSLDDQDQESYAYWKKLLWTAPELLRDPHRDPAG---TQKGDVYSFGIIVH 863
Query: 774 EVIVRGEPYCMLSF--TPEEIIDKLCRPP----PLIRPSVSMGAAPPEAVSVMRQCWSEA 827
E++ R P+ +P+EII + P P RP V + ++M +CWSE
Sbjct: 864 EIVSRQGPFYTGDDEKSPKEIIKLVINGPDGYNPPFRPKVDE-MYYEDVNNIMVKCWSED 922
Query: 828 PDLRPDFNRLHDVFRQMQRGRKI-NIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTE 886
P R DF L + R++ + + NI+D++ + +E+Y+NNLE L+ ERT+ EK+K E
Sbjct: 923 PMERLDFTVLKTIIRKINKENESGNILDNLLQRMEQYANNLEALVEERTQDYFEEKRKCE 982
Query: 887 QLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYT 946
+LL ++LPRSVA +L++G V E +++V+IYFSDIVGFT+++A+ST +QVVDLLNDLYT
Sbjct: 983 ELLYQLLPRSVAAQLIMGKSVIAETYDQVTIYFSDIVGFTSISAQSTPMQVVDLLNDLYT 1042
Query: 947 TFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPD 1005
FD+ +E + VYKVETIGDAYMVV GLP R + HA ++ +AL LL +F +RH P+
Sbjct: 1043 CFDSIVENFDVYKVETIGDAYMVVSGLPVRNGNLHAREISRLALALLAAVHKFTIRHRPN 1102
Query: 1006 TPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLA 1065
L LRIGLH+GPC AGVVGL MPRYCLFGDTVNTASRMES G +I IS TT L
Sbjct: 1103 EQLKLRIGLHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGEPLKIHISHTTKTLLDT 1162
Query: 1066 AGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
G +++ RGL +KGKG M TYWL G+
Sbjct: 1163 FGTFEVTERGLVPMKGKGEMLTYWLNGE 1190
>UniRef50_Q07553 Cluster: Guanylate cyclase 32E precursor; n=3;
Diptera|Rep: Guanylate cyclase 32E precursor - Drosophila
melanogaster (Fruit fly)
Length = 1163
Score = 437 bits (1076), Expect = e-120
Identities = 239/506 (47%), Positives = 321/506 (63%), Gaps = 14/506 (2%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPALVFDE-CWR 657
++G+ V ++ + ++++ R L LM+ +R EN+ FIG + ++F C R
Sbjct: 551 FRGNIVAMKKIHKK-SVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCAR 609
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
GSLEDVL +D+ LD F SL+SD++KGM YLH S + +HG L S NC++DSRWV +++
Sbjct: 610 GSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQIS 669
Query: 718 DYGLPALHRTQGLP-PAQRTPRELLWTAPELIREA-REGGGWLATQSGDVFSFAIIMQEV 775
D+GL L Q P ++ + L APEL+R+A R G G +Q GDV+SF I++ E+
Sbjct: 670 DFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRG---SQKGDVYSFGILLYEM 726
Query: 776 IVRGEPYCMLSFTPEEIIDKLCRPPPL----IRPSVSMGAAP-PEAV-SVMRQCWSEAPD 829
I R P+ +++ EEII + P L RP+++ P+ + + QCW E P+
Sbjct: 727 IGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPE 786
Query: 830 LRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLL 889
+RPD + +++Q G K NI D+M ++EKY+ NLE L++ERT L EKKKT+ LL
Sbjct: 787 VRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLL 846
Query: 890 NRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFD 949
+MLPR VAE L G VE E F+ V+I FSDIVGFT L ST +VV++LND YT D
Sbjct: 847 YQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCD 906
Query: 950 AAIEQYRVYKVETIGDAYMVVGGLP-QRTRDHAESVATMALHLLHLAGRFRVRHLPDTPL 1008
+ I Y VYKVETIGDAYMVV GLP Q HA +A++ALHLL G ++RH P +
Sbjct: 907 SIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETV 966
Query: 1009 HLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGG 1068
LRIG+H+GPC AGVVG MPRYCLFGDTVNTASRMESTG + RI IS T + L G
Sbjct: 967 QLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGS 1026
Query: 1069 YKLRSRGLTQIKGKGAMHTYWLLGKE 1094
Y RGLT IKGKG M TYWL ++
Sbjct: 1027 YVCIERGLTSIKGKGDMRTYWLTKRQ 1052
>UniRef50_UPI0000F1D453 Cluster: PREDICTED: similar to receptor type
guanylyl cyclase; n=3; Danio rerio|Rep: PREDICTED:
similar to receptor type guanylyl cyclase - Danio rerio
Length = 479
Score = 430 bits (1059), Expect = e-118
Identities = 228/478 (47%), Positives = 311/478 (65%), Gaps = 18/478 (3%)
Query: 629 QNLRQENVNPFIGCLCE-GRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGM 687
++L N+ FIG E +P ++ + C +GSL+D+L + IKLDWTF+ SL+ D+VKGM
Sbjct: 7 RDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGM 66
Query: 688 RYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPA---LHRTQGLPPAQRTPRELLWTA 744
YLH SPL+ HG LSS +CVVDSR+VL+VTD+GL + L + + LLW A
Sbjct: 67 DYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSTVCLIKVTHYINDHFYHKSLLWRA 126
Query: 745 PELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLS--FTPEEIIDKL----CR 798
PEL+R++ G TQ GDV+SFAII QEV+ R P+ + + F+P EI++++ C
Sbjct: 127 PELLRQSIPANG---TQKGDVYSFAIIAQEVVYRRGPFYIPNSHFSPREIVERVRAGGCS 183
Query: 799 PPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQ-RGRKINIVDSMF 857
P RP + E S++ CW E P RPDF+ + ++ G NI+D +
Sbjct: 184 PS---RPYIDRAECVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLL 240
Query: 858 EMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSI 917
+E+Y+ NLEE++ ERT +L EKK+ E LL +MLPRSVA +L+ G V E ++ V+I
Sbjct: 241 SRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTI 300
Query: 918 YFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT 977
YFSDI GFTA++A T +QVV++LNDLYT FD I+ + VYKVETIGDAYMVV GLP R
Sbjct: 301 YFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRN 360
Query: 978 -RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGD 1036
DHA+ +A M+L ++ F H+P+ L +RIG+H+GPC AGVVGL MPRYCLFGD
Sbjct: 361 GDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGD 420
Query: 1037 TVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
TVNTASRMES G +I +SS+T L ++ RG IKGKG + T+WLLG++
Sbjct: 421 TVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKGKGWVRTFWLLGED 478
>UniRef50_Q8T8L6 Cluster: Guanylate cyclase; n=5; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1276
Score = 429 bits (1056), Expect = e-118
Identities = 231/528 (43%), Positives = 334/528 (63%), Gaps = 27/528 (5%)
Query: 589 NRVVVDRRIRYKGDAVHLRHLQVTGT----LELKRKSTDVLLLMQNLRQENVNPFIG-CL 643
N + + +KG V ++ L + L+L R L M++L+ +++ F G C+
Sbjct: 738 NTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACI 797
Query: 644 CEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSS 703
+V + C +GSLED+L + I+LD + SLL DLVKG+ +LH S +R+HGRL S
Sbjct: 798 DFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKS 857
Query: 704 RNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTP----RELLWTAPELIREAREGGGWLA 759
NCVVDSR+VL+VTD+GL LH + + + +++LWTAPEL+R++ +
Sbjct: 858 SNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPP--MG 915
Query: 760 TQSGDVFSFAIIMQEVIVRGEPYCMLS--FTPEEIIDKLCRP-----PPLIRPSVSM--- 809
TQ GD++SFAII+ E++ R + + + +P EI+ ++ +P PL RP VS
Sbjct: 916 TQKGDIYSFAIILHEMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPL-RPWVSETGE 974
Query: 810 ----GAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKI-NIVDSMFEMLEKYS 864
A +S+M CWSE P RP+ + + R + R + N+VD++ + +E+Y+
Sbjct: 975 GEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYA 1034
Query: 865 NNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVG 924
NNLE L+ ERT++ EKKK E+LL+++LP ++A+ L+ G V+ E ++ V+IYFSDIVG
Sbjct: 1035 NNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVG 1094
Query: 925 FTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESV 984
FT+L+++ST +QVV LLNDLY FD ++ ++VYKVETIGDAYMVV GLP+R DHA +
Sbjct: 1095 FTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQI 1154
Query: 985 ATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRM 1044
A M+L LLH F +RH P L LRIG+H+G AGVVG MPRYCLFGDTVNT+SRM
Sbjct: 1155 AQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRM 1214
Query: 1045 ESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
ES G +I +S T + L+ G+KL RG ++KGKG TYWL G
Sbjct: 1215 ESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1262
>UniRef50_Q8MLX0 Cluster: CG3216-PB, isoform B; n=7;
Endopterygota|Rep: CG3216-PB, isoform B - Drosophila
melanogaster (Fruit fly)
Length = 1141
Score = 421 bits (1036), Expect = e-116
Identities = 220/499 (44%), Positives = 315/499 (63%), Gaps = 28/499 (5%)
Query: 598 RYKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVF--DE 654
++KG+ V ++ + V ++L + + +++ EN F+G C+ RP ++ +
Sbjct: 633 QFKGERVAIKKVNVK-KVDLTPQLLWEIKQARDVSHENTVRFVGACIDLPRPTVLILTEY 691
Query: 655 CWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVL 714
C RGSL+DVL + I+LDW FR+SL+ D+VKGM YLH S + AHG+L S NC++D R+VL
Sbjct: 692 CSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDGRFVL 751
Query: 715 RVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQE 774
+++D+GL L TP + + R+ +L TQ GDV+SF II++E
Sbjct: 752 KISDFGLRTL----------TTPSDFV----------RDQNYYLTTQRGDVYSFGIILEE 791
Query: 775 VIVRGEPY--CMLSFTPEEIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRP 832
++ RG PY I+ K+ R RP + PP+ + +M +CW++ + RP
Sbjct: 792 IVNRGGPYQEARQQMDVHTILHKV-RQCNGFRPLIRERECPPDLLELMEKCWADNQEERP 850
Query: 833 DFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRM 892
F+ + R + +G N++D + +E+Y+NNLE L+ E+T QL +EK++TE+LL ++
Sbjct: 851 TFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQI 910
Query: 893 LPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAI 952
LPR VA++LM G VEPEEF V+IYFSDIVGFT L ARS+ + VV+ LNDLY+TFD I
Sbjct: 911 LPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRII 970
Query: 953 EQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLR 1011
Y VYKVETIGDAY+VV GLP+ D HA +A MAL +L F +RH P+ + +R
Sbjct: 971 GFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIR 1030
Query: 1012 IGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKL 1071
IG+H+G CAGVVG MP YCLFGDTVNTASRMESTG +I +SS T L G +++
Sbjct: 1031 IGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQM 1090
Query: 1072 RSRGLTQIKGKGAMHTYWL 1090
RG ++KGKG + TYWL
Sbjct: 1091 EQRGDVELKGKGTVTTYWL 1109
>UniRef50_UPI0000E46159 Cluster: PREDICTED: similar to natriuretic
peptide receptor A; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to natriuretic peptide
receptor A - Strongylocentrotus purpuratus
Length = 853
Score = 418 bits (1030), Expect = e-115
Identities = 221/474 (46%), Positives = 296/474 (62%), Gaps = 15/474 (3%)
Query: 628 MQNLRQENVNPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKG 686
M+NL N+ F+G C+ ++ D C RGSL+D+L D +KLDW FR SLL D V+G
Sbjct: 378 MRNLEHTNIVRFVGACVDPPNQTIMTDYCPRGSLQDILENDHLKLDWMFRQSLLMDAVRG 437
Query: 687 MRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPE 746
YLH S + HGR+ S NCVVD R+VL++TD+G+P+L R + + +LLW APE
Sbjct: 438 THYLHDSGIGVHGRMMSSNCVVDGRFVLKLTDFGIPSL-RPSFIDSENKY--KLLWRAPE 494
Query: 747 LIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYC--MLSFTPEEIID--KLCRPPPL 802
+R T+ GD++S IIM E+ R P+ ++I++ K P
Sbjct: 495 HLRHPNSP----PTKEGDIYSLGIIMLEIGTRSGPFDEERKFMDTDQILECLKSTTTEPP 550
Query: 803 IRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKI--NIVDSMFEML 860
R S+ + PE +M++CW E P RP + L +++ +G NI+D++ +
Sbjct: 551 FRASIPESSWGPEIKDLMKRCWEENPSDRPTASTLQSTLKKVNKGTSSGGNILDNLLNRM 610
Query: 861 EKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFS 920
E+Y++NLE L+ ERT EKK++E LL +LPRSVAE+L LG V+PE +E V+I+FS
Sbjct: 611 EQYASNLEALVEERTAAFLEEKKRSETLLYEVLPRSVAEQLKLGKSVDPESYENVTIFFS 670
Query: 921 DIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTR-D 979
DIVGFTA+++ ST +QVV LLNDLY FD I VYKVETIGDAYMVV GLP R
Sbjct: 671 DIVGFTAISSESTPLQVVALLNDLYICFDGIIANSDVYKVETIGDAYMVVSGLPIRNGIT 730
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
HA +A M+L LL F++RH PD L LR G+H+GPC AGV+GL MPRYCLFGDTVN
Sbjct: 731 HAREIAEMSLSLLEAVKSFKIRHRPDEQLKLRAGIHSGPCVAGVIGLKMPRYCLFGDTVN 790
Query: 1040 TASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
TASRMES G A +I SS E L ++L RG ++KGKG+ TYWLL +
Sbjct: 791 TASRMESNGEAMKIHASSDCKEILDKFDAFELDLRGQVEMKGKGSQTTYWLLSR 844
>UniRef50_Q6UCJ4 Cluster: Guanylate cyclase PcGC-M2 precursor; n=5;
Pleocyemata|Rep: Guanylate cyclase PcGC-M2 precursor -
Procambarus clarkii (Red swamp crayfish)
Length = 1423
Score = 415 bits (1022), Expect = e-114
Identities = 251/521 (48%), Positives = 314/521 (60%), Gaps = 33/521 (6%)
Query: 599 YKGDAVHLRHLQVTGTL-ELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRP--------- 648
YKG V L+ + + +L R + + M+ ++Q+NV FIG E R
Sbjct: 657 YKGTMVCLKAVPLNQKRPDLSRNTMKEMRNMREVKQDNVCAFIGAFVEHRKLTHGDHNKV 716
Query: 649 ALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVV 708
LV + C RGSL D+L +DIKLD F SL+ DL++GM +LH S AHG L S NCVV
Sbjct: 717 TLVTEYCTRGSLLDILAMEDIKLDSLFISSLVHDLLRGMVFLH-SHFGAHGNLKSSNCVV 775
Query: 709 DSRWVLRVTDYGLPALH----RTQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGD 764
+ RWVL+VTDYGL L R+ + R +LW PEL+R + G T+ GD
Sbjct: 776 NGRWVLQVTDYGLHDLRCETLRSLEKDDRGQFDRHMLWRPPELLRAGIDAPG---TKEGD 832
Query: 765 VFSFAIIMQEVIVRGEPYCMLSFTPEE---IIDKL------CRPP--PLIRPSVSMGAAP 813
V+SF II+ E+I R PY ++ II KL PP P + V M
Sbjct: 833 VYSFGIILHEMIGRQGPYNTYDSDTDDSSVIIKKLKAGSTVTGPPYRPDLNKIVDMPFGS 892
Query: 814 PEAV-SVMRQCWSEAPDLRPDFNRLHDVFRQMQ-RGRKINIVDSMFEMLEKYSNNLEELI 871
E+V S M+ W E P RP F L + M+ + RK N++D M +M+E+YS NLEEL+
Sbjct: 893 DESVRSAMQLSWEENPVERPSFRALRIKLKNMKDKSRKGNLMDHMVQMMEQYSKNLEELV 952
Query: 872 RERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAAR 931
RT+QL E++KT+ LL+RMLP SVA L G VEP+ F+ V+IYFSDIVGFT+L+A
Sbjct: 953 TNRTQQLRDEQRKTKDLLHRMLPSSVAASLTQGIAVEPQGFDSVTIYFSDIVGFTSLSAE 1012
Query: 932 STAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALH 990
ST QVV LNDLYT FD I Y VYKVETIGDAYMVV GLP+ HA +A+MAL
Sbjct: 1013 STPYQVVRFLNDLYTLFDNIIRGYDVYKVETIGDAYMVVSGLPKPNMGRHAGEIASMALE 1072
Query: 991 LLH-LAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
LL + +F +RH P+ L LRIGLHTGP AGVVGLTMPRYCLFGDTVNTASRMES G
Sbjct: 1073 LLDGVQNKFIIRHRPEKKLLLRIGLHTGPVIAGVVGLTMPRYCLFGDTVNTASRMESNGE 1132
Query: 1050 AWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
RI IS L GGY + RGL +KGKG + T+WL
Sbjct: 1133 PLRIHISEQCHIALKNLGGYVMEPRGLVTMKGKGEVLTFWL 1173
>UniRef50_A7SJA1 Cluster: Predicted protein; n=4; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 520
Score = 414 bits (1019), Expect = e-114
Identities = 214/437 (48%), Positives = 276/437 (63%), Gaps = 14/437 (3%)
Query: 623 DVLLLMQNLRQ---ENVNPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLS 678
D+L+ M+ +R N+ +IG C +V C RGSL+++L D+I LDW FR S
Sbjct: 85 DMLIEMKQVRDVQHTNLLHYIGVCTTPPNICIVSQYCHRGSLQEILANDEISLDWFFRES 144
Query: 679 LLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPP---AQR 735
+D+ GM +H S + HG L S C++DSRWV +V D+GL L Q P
Sbjct: 145 FANDIAMGMHVIHTSSIHVHGDLRSSKCLIDSRWVCKVADFGLNLLKANQRPDPEIGVHA 204
Query: 736 TPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDK 795
L W APEL++ + + TQ GDV+SF II+ E++ R EPY F P E+I++
Sbjct: 205 QYSRLFWRAPELLQNEKSTNKPVPTQMGDVYSFGIILNELLTREEPYATTEFAPIEVIER 264
Query: 796 L-CRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQ--RGRKINI 852
+ C P RP +M QCW++ P RP F+ D+ RQ++ +G K +I
Sbjct: 265 IRCHLNPPFRPETPFEIRNRSVTKLMTQCWNDDPQARPTFS---DIKRQLRLLKGGKSSI 321
Query: 853 VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF 912
VD+M ++E Y+ LE ++ ERT QL EK KT++LL +MLPR +AE L G V E +
Sbjct: 322 VDNMLRLMENYTEQLETIVDERTRQLADEKAKTDELLYKMLPRYIAESLKRGEPVIAESY 381
Query: 913 EEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGG 972
V+I+FSDIVGFT LAA ST +QVVDLLNDLYT FD I+++ VYKVETIGDAYMVV G
Sbjct: 382 SSVTIFFSDIVGFTELAAASTPLQVVDLLNDLYTCFDTIIDKHDVYKVETIGDAYMVVSG 441
Query: 973 LPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRY 1031
LP R HA +ATMAL+LL G FR RHLP+ P+HLRIG+HTG C AGVVGL MPRY
Sbjct: 442 LPVRNGHRHAGEIATMALNLLSSMGNFRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRY 501
Query: 1032 CLFGDTVNTASRMESTG 1048
CLFGDTVN ASRMESTG
Sbjct: 502 CLFGDTVNYASRMESTG 518
>UniRef50_O01779 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1146
Score = 405 bits (998), Expect = e-111
Identities = 216/475 (45%), Positives = 303/475 (63%), Gaps = 19/475 (4%)
Query: 628 MQNLRQENVNPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKG 686
M++L +N+N FIG CL + ++ C RGSL DV+ +++D F LSL+ D+ G
Sbjct: 655 MRSLDHDNLNKFIGLCLNSQQLLSIWRYCSRGSLADVISRSSMQMDSFFMLSLIRDIANG 714
Query: 687 MRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPE 746
+ ++H S L HG LSSR+C++D RW ++++D+GL + +G+ + + +LW APE
Sbjct: 715 LGFIHTSMLHFHGYLSSRSCLIDDRWQVKISDFGL---NEVRGMD--KLSTENMLWWAPE 769
Query: 747 LIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFT--PEEIIDKLCRPP-PLI 803
++R + ++ D++SF II EVI R + + + PEEII +L + I
Sbjct: 770 VLRGLEQ-----RSKEADIYSFGIICSEVITRSSAFDLENRKEKPEEIIYQLKKGGFNAI 824
Query: 804 RPSVSMGAA---PPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEML 860
RPS+ A P V ++R CW+E P RP +++ + R M G+K N++D +F ML
Sbjct: 825 RPSLLTDEALEINPALVHLIRDCWTEKPSERPPIDQVRSLLRGMNDGKKGNLMDHVFNML 884
Query: 861 EKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFS 920
E Y++ LEE + ERT++L E+KK++ LL RMLP++VAE+L G +EPE FE V+I+FS
Sbjct: 885 ETYASTLEEEVNERTKELVEEQKKSDVLLYRMLPKTVAEKLKAGISIEPETFELVTIFFS 944
Query: 921 DIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-RD 979
D+V FT LA++ T +QVV LLNDLYT FD+ IEQ VYKVETIGD Y+ V GLP R D
Sbjct: 945 DVVQFTTLASKCTPLQVVQLLNDLYTIFDSIIEQNDVYKVETIGDGYLCVSGLPHRNGHD 1004
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
H + +A M+L L FRV H+P ++LRIG++ G AGVVGLTMPRYCLFGD VN
Sbjct: 1005 HIKHIARMSLAFLSSLAEFRVAHMPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVN 1064
Query: 1040 TASRMESTGAAWRIQISSTTAEKLL-AAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
TASRMES G RI +SS L GG++ RG IKGKG M+TYWLLG+
Sbjct: 1065 TASRMESNGKPGRIHVSSEANHLLTHVVGGFRTEERGEVIIKGKGVMNTYWLLGE 1119
>UniRef50_UPI0000E4627A Cluster: PREDICTED: similar to membrane
guanylyl cyclase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to membrane guanylyl cyclase -
Strongylocentrotus purpuratus
Length = 1376
Score = 404 bits (995), Expect = e-111
Identities = 212/447 (47%), Positives = 290/447 (64%), Gaps = 13/447 (2%)
Query: 615 LELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDW 673
+EL R + +++L+ ++V FIG C+ +++ + C +GSL+D+L D I+LD
Sbjct: 824 VELNRNVLMEIKHVRDLQHDHVIKFIGACIDAPNISIMTEYCPKGSLQDILENDSIELDE 883
Query: 674 TFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQ-GLPP 732
F+ SL+ D+VKGM YLH S ++ HG L S NCVVDSR+VL++TD+GL + P
Sbjct: 884 LFKYSLMYDIVKGMLYLHNSVIQTHGNLKSSNCVVDSRFVLKITDFGLTSFREPDHAFEP 943
Query: 733 AQRTP----RELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCM--LS 786
+ + LWTAPEL+R G TQ GDV+SF II+QE++ R + + +
Sbjct: 944 DEEDSYKYYQRRLWTAPELLRLPEIPSG--GTQKGDVYSFGIILQEIMYREGVFYIKDVD 1001
Query: 787 FTPEEIIDKLCRP-PPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQ 845
PEEI+ K+ P RP++ E ++++ CW E +RPD+++L R++
Sbjct: 1002 LMPEEIVKKVANGYKPAFRPTIDRVTCSQEMMTLITNCWKEDSTIRPDYSQLRGTMRKLN 1061
Query: 846 RGRKIN-IVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLG 904
+ + +VD++ +E+Y++NLE L++ERTE EK+K E+LL ++LPR VAE L G
Sbjct: 1062 KNSENKGLVDTLLSRMEQYASNLESLVQERTEAFYEEKRKAEELLYQILPRPVAEELKKG 1121
Query: 905 SRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIG 964
V E FE V+IYFSDIVGFT L++ ST ++VVDLLNDLYT FDA I+ + VYKVETIG
Sbjct: 1122 KPVTAESFECVTIYFSDIVGFTKLSSASTPLEVVDLLNDLYTCFDAVIDNFNVYKVETIG 1181
Query: 965 DAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGV 1023
DAYM V GLP R D HA +A M+L LLH FR+RH P+ L LRIG+HTGP AGV
Sbjct: 1182 DAYMCVSGLPIRNGDFHAREIARMSLALLHEITSFRIRHRPEERLRLRIGVHTGPVVAGV 1241
Query: 1024 VGLTMPRYCLFGDTVNTASRMESTGAA 1050
VGL MPRYCLFGDTVNTASRMES G A
Sbjct: 1242 VGLKMPRYCLFGDTVNTASRMESNGEA 1268
>UniRef50_A7RUA8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 443
Score = 403 bits (992), Expect = e-110
Identities = 190/434 (43%), Positives = 284/434 (65%), Gaps = 6/434 (1%)
Query: 650 LVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVD 709
+V + C +GSL+D+L+ D++KLDWTF++S D+ +GM +H S + HGRL S+N VVD
Sbjct: 12 IVNEFCAKGSLQDILLDDNLKLDWTFKMSFAMDIARGMEEIHKSAIGPHGRLKSKNVVVD 71
Query: 710 SRWVLRVTDYGLPALHRTQG-LPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSF 768
S W+ ++ DYGL ++ ++Q L + ELLWTAPEL+RE+ G +++ S D +++
Sbjct: 72 SYWICKIADYGLGSIRQSQNDLGQDGKAYSELLWTAPELLRESH---GRVSSSSADCYAY 128
Query: 769 AIIMQEVIVRGEPYCMLSFTPEEIIDKLCRP-PPLIRPSVSMGAAPPEAVSVMRQCWSEA 827
II+QE+ +R P+ L +P+E++ + + P RP V +AP +M CW E
Sbjct: 129 GIILQEIALREAPFSTLLLSPKEVVYHVRKGMTPYCRPQVPPDSAPSAYRELMAICWDEV 188
Query: 828 PDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQ 887
P+ RP F+ + + ++M G+ NIVD+M M+EKY+ +LE L++ERT QL+ EK KT++
Sbjct: 189 PERRPTFSGVLKILKKMNNGKVSNIVDNMVSMMEKYTTDLESLVKERTRQLETEKSKTDE 248
Query: 888 LLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTT 947
LL RMLPR +A++L G ++ E F EV++++ DIV FT + A S +QV+ LLND+Y+
Sbjct: 249 LLYRMLPRLIADQLKAGLPLKAESFSEVTVFYCDIVDFTVITALSEPMQVIKLLNDVYSL 308
Query: 948 FDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDT 1006
FD + +Y +YKVET+ D+ +VV GLP+R + HA +A M+LHLL+ FR+ HLPDT
Sbjct: 309 FDTIMGRYDIYKVETVRDSCLVVSGLPERNGNRHASEIAAMSLHLLNYVTDFRIEHLPDT 368
Query: 1007 PLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAA 1066
L R+ +HTGPC AG+VGL PRY +FG+TVN +ES G I +SS T L
Sbjct: 369 RLEFRMAIHTGPCVAGIVGLKKPRYDIFGETVNIVKHLESAGIPQSIHVSSPTCRLLTTL 428
Query: 1067 GGYKLRSRGLTQIK 1080
GG+ L +RG IK
Sbjct: 429 GGFMLETRGEMLIK 442
>UniRef50_Q9XTY1 Cluster: Guanylate cyclase; n=2; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1012
Score = 402 bits (989), Expect = e-110
Identities = 211/473 (44%), Positives = 306/473 (64%), Gaps = 20/473 (4%)
Query: 628 MQNLRQENVNPFIGCLCEGRPAL-VFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKG 686
M+N+ +N+ FIG + + ++ C RGSL+DV+ +++DW F+ SL+ D+
Sbjct: 537 MRNVDNDNLCKFIGLSLDSPTLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADA 596
Query: 687 MRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPE 746
+ YLH SP+ HG LSS C+VD RW ++V+ +GL A+ + + + R+ L TAPE
Sbjct: 597 IYYLHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQYE-----VKEQRDFLHTAPE 651
Query: 747 LIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLS--FTPEEIIDKLC---RPPP 801
IR+ T+ D++SFAII E+I + + + + F EE++ K+ R PP
Sbjct: 652 HIRDTNLP----ITKEMDIYSFAIICSELITKKSAWDLENETFDIEELVYKIKKGGRSPP 707
Query: 802 LIRPSVSMGAAPPEAVSVM-RQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEML 860
RPS+ ++S++ R CW+E PD RP ++ + + M R N++D +F +L
Sbjct: 708 --RPSLETEDEHNGSMSLLVRDCWNENPDQRPTSEQIKTLMKSMNHNRSSNLMDHVFNVL 765
Query: 861 EKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFS 920
E+Y++NLE+ ++ R ++L EKK+++ LL RMLP+ VAE+L LG VEPE F+ V+I+FS
Sbjct: 766 EQYASNLEDEVQARMKELTEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFS 825
Query: 921 DIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-RD 979
D+V FT LA+R T +QVV+LLNDLYTTFDA IEQ+ VYKVETIGD Y+ V GLP R +
Sbjct: 826 DVVSFTTLASRCTPLQVVNLLNDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNE 885
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
HA+ +++M+ LL FRV HLP +++R+GLHTGP GVVG+TMPRYCLFGD+VN
Sbjct: 886 HAKEISSMSFSLLKAIKTFRVPHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVN 945
Query: 1040 TASRMESTGAAWRIQISSTTAEKLL-AAGGYKLRSRGLTQIKGKGAMHTYWLL 1091
TASRMES G R+ IS+ + L GGY+ RG +KGKGA+ T+WLL
Sbjct: 946 TASRMESNGKPGRVHISTECMKFLTEVIGGYQTEPRGEVIVKGKGAVQTHWLL 998
>UniRef50_Q19187 Cluster: Guanylate cyclase; n=3; Bilateria|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1280
Score = 398 bits (979), Expect = e-109
Identities = 234/531 (44%), Positives = 304/531 (57%), Gaps = 39/531 (7%)
Query: 599 YKGDAVHLRHLQV-TGTLELKRKSTDVLLLMQNLRQENVNPFIGCL-CEGRPALVFDECW 656
YKG V L+ L +L R++ L M+ L NVN F+G + C+ +V + C
Sbjct: 688 YKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQYSVTVVREYCS 747
Query: 657 RGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRV 716
+GSL D+L +++KLD + S + DLVKGM Y+H S L+ HG L S NC++ SRW L++
Sbjct: 748 KGSLHDILRNENLKLDHMYVASFVDDLVKGMVYIHDSELKMHGNLKSTNCLITSRWTLQI 807
Query: 717 TDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAREGGGWLA-----TQSGDVFSFAII 771
D+GL L + LWTAPE A G LA T D +SF II
Sbjct: 808 ADFGLRELREGIMYDSSYNIWENFLWTAPE----AMTINGSLAISNPPTPKADAYSFGII 863
Query: 772 MQEVIVRGEPYCML---------------SFTPEEIIDKLCR---PPPLIRPSVSMGAAP 813
E+ R PY + S +++K R P RP S
Sbjct: 864 FHEIFTREGPYKIYVQRGDVNGEAAPKKDSVECRALVEKTVRRVYSDPYFRPDTSDLEVQ 923
Query: 814 PEAVSVMRQCWSEAPDLRPDF----NRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEE 869
VM CW P RP+F N+L +F Q+ K NI+D M M+EKY LE+
Sbjct: 924 NYVKEVMAACWHHDPYQRPEFKTIKNKLKPLFHQIY---KQNIMDHMVLMMEKYQTQLED 980
Query: 870 LIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALA 929
L+ ERT +L E+++++ LL RMLP SVAE+L+ G V PE F V+IYFSDIVGFT ++
Sbjct: 981 LVDERTIELKDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTIS 1040
Query: 930 ARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ-RTRD-HAESVATM 987
ST ++VV LN LYT FD+ I +Y VYKVETIGDAYMVV G+PQ +T + HAE +A M
Sbjct: 1041 GESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYKTMEYHAEQIAMM 1100
Query: 988 ALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
A+H+L F + H PL +RIG+HTGPC AGVVG TMPRY LFGDTVNTASRMES
Sbjct: 1101 AIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESN 1160
Query: 1048 GAAWRIQISSTTAEKLLAAG-GYKLRSRGLTQIKGKGAMHTYWLLGKEGFD 1097
G A RI SS+T + L + G+ L RG IKGKG M TYWL G+ G++
Sbjct: 1161 GEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWLNGRAGYE 1211
>UniRef50_Q23310 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1170
Score = 396 bits (975), Expect = e-108
Identities = 213/477 (44%), Positives = 298/477 (62%), Gaps = 20/477 (4%)
Query: 628 MQNLRQENVNPFIGCLCEGRPAL--VFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVK 685
M+N +N+N FIG LC P L ++ C RGSL DV+ +++D F SL+ D+
Sbjct: 648 MRNFDNDNLNKFIG-LCLDGPQLFSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISN 706
Query: 686 GMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAP 745
G+ ++H S L+ HG L+SR C++D RW ++++ YGL ++ RT P + +LLWT P
Sbjct: 707 GLLFIHNSFLKCHGHLTSRCCLIDDRWQIKISGYGLKSV-RTFENPKKE----DLLWTPP 761
Query: 746 ELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFT--PEEIIDKLCRPPPL- 802
E +R E GD++SF II E++ R + + + P+ II ++ +
Sbjct: 762 ENLRNENEE----RLPEGDIYSFGIICSEILTRSSAFDLENRKEKPDVIIYQVKKGGHNP 817
Query: 803 IRPSVSMGAAP---PEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEM 859
+RPS+ G P + ++R CW+E P RP ++ M+ GRK N++D +F M
Sbjct: 818 MRPSLDTGETVEINPALLHLIRDCWTERPSERPSIEQVRGHLNGMRDGRKSNLMDHVFNM 877
Query: 860 LEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYF 919
LE Y++ LEE + +RT++L EKKK++ LL RMLP+ VA++L LG VEPE FE+V+I+F
Sbjct: 878 LETYASTLEEEVSDRTKELVEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFF 937
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-R 978
SD+V FT LA + T +QVV LLNDLYT FD IEQ VYKVETIGD Y+ V GLP R
Sbjct: 938 SDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGN 997
Query: 979 DHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTV 1038
+H +A M+L L FRV+HLP ++LRIG++ G AGVVGLTMPRYCLFGD V
Sbjct: 998 EHIRHIARMSLGFLSSLEFFRVQHLPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAV 1057
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLL-AAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
NTASRMES G +I +++ + L GG++ SRG IKGKG M TYWLLG++
Sbjct: 1058 NTASRMESNGKPGKIHVTAEANQMLTQVVGGFRTESRGEVIIKGKGVMETYWLLGEQ 1114
>UniRef50_Q4SW10 Cluster: Guanylate cyclase; n=4; Tetraodontidae|Rep:
Guanylate cyclase - Tetraodon nigroviridis (Green puffer)
Length = 1128
Score = 394 bits (970), Expect = e-108
Identities = 236/537 (43%), Positives = 331/537 (61%), Gaps = 43/537 (8%)
Query: 577 RVPSAPSSTCSVNRVVVDRRIRYKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENV 636
+V S+P + +++R + ++G+ V +++ +EL RK L M++++ E++
Sbjct: 580 KVSSSPVTMTTLSRRQRPTCLPFQGNIVAIKYTN-RKRVELNRKVLFELKHMRDVQNEHL 638
Query: 637 NPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPL 695
F+G C+ ++ + C RGSL+D+L D I LDW F+ SL++D+VKGM +LH S +
Sbjct: 639 TRFVGACIDPPNTCILTEYCSRGSLQDILENDSITLDWMFKFSLINDIVKGMLFLHNSVI 698
Query: 696 RAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLP--PAQRTPRELLWTAPELIR-EAR 752
+HG+L S NCVVD+R+VL+VTDYGL +L R++G A + LW APEL+R EA
Sbjct: 699 LSHGKLKSSNCVVDNRFVLKVTDYGLSSL-RSEGPSGRDAHAYYAQRLWLAPELLRMEAP 757
Query: 753 EGGGWLATQSGDVFSFAIIMQEVIVRGEPYCM--LSFTPEEIID---KLCRPPPLIRPSV 807
G TQ GDV+SF II+QEV +R + + + +P+ + LC P V
Sbjct: 758 PPRG---TQKGDVYSFGIILQEVALRRGAFYLEGEALSPKGDLGGRRGLCTPRSSSSSGV 814
Query: 808 S--MGAAPPEAVSVMRQCWSEAPDLRPDFN-RLH--DVFRQMQR---------------- 846
S PP + V R E P LRP + + H ++ + MQR
Sbjct: 815 SHTFLENPPHSEIVDRVVLGEWPCLRPSVDPQAHSPELGQVMQRCWAEEPTERPEFSQIR 874
Query: 847 -------GRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAE 899
+ NI+D++ +E+Y+NNLEEL+ ERT+ EK+K E LL ++LP SVAE
Sbjct: 875 LLLRNTTESRTNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAE 934
Query: 900 RLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYK 959
+L G V+ E F+ V+IYFSDIVGFTA++A ST ++VV LLNDLYT FDA I+ + VYK
Sbjct: 935 QLKRGETVQAEAFDSVTIYFSDIVGFTAISAESTPLEVVTLLNDLYTCFDAIIDNFNVYK 994
Query: 960 VETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGP 1018
VETIGDAYMVV GLP R HA +A MAL LL F++RH P+ L LRIG+H+GP
Sbjct: 995 VETIGDAYMVVSGLPVRNGALHAPEIARMALALLDAVRTFQIRHRPEEQLKLRIGIHSGP 1054
Query: 1019 CCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRG 1075
CAGVVGL MPRYCLFGDTVNT+SRMES+G A +I +S+ T + L GG++L+ RG
Sbjct: 1055 VCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATGDILQDFGGFRLQLRG 1111
>UniRef50_Q7JP51 Cluster: Guanylate cyclase; n=6; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1111
Score = 392 bits (966), Expect = e-107
Identities = 213/475 (44%), Positives = 297/475 (62%), Gaps = 19/475 (4%)
Query: 628 MQNLRQENVNPFIGCLCEGRPAL-VFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKG 686
++NL Q+N+N FIG +G L V+ C RGS+ DV++ I++D F SL+ D+V G
Sbjct: 610 LRNLDQDNLNRFIGLCLDGPQMLSVWRFCSRGSIADVILKATIQMDNFFIYSLIKDMVHG 669
Query: 687 MRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPE 746
+ +LHGS + HG L+S+ C++D RW +++++YGL L P ++LLW+APE
Sbjct: 670 LVFLHGSMVGYHGMLTSKCCLIDDRWQVKISNYGLQDLRS-----PEMYEKKDLLWSAPE 724
Query: 747 LIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCM--LSFTPEEIIDKLCR-----P 799
L+R G ++ GDV+S II E+I R + M PEEII L + P
Sbjct: 725 LLRAEDIKG----SKEGDVYSLGIICAELITRKGVFNMEDRKEDPEEIIYLLKKGGLKSP 780
Query: 800 PPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEM 859
P + ++ P + ++R C++E P RP + R M R N++D +F M
Sbjct: 781 RPDLEYDHTI-EINPALLHLVRDCFTERPSERPSIETVRSQLRGMNSSRNDNLMDHVFNM 839
Query: 860 LEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYF 919
LE Y+++LEE + ERT++L EKKK++ LL RMLP++VA++L LG VEPE FE+V+I+F
Sbjct: 840 LESYASSLEEEVSERTKELVEEKKKSDVLLYRMLPKTVADKLKLGQTVEPETFEQVTIFF 899
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-R 978
SD+V FT LA++ T +QVV+LLNDLYT FD IE++ VYKVETIGD Y+ V GLP R
Sbjct: 900 SDVVQFTTLASKCTPLQVVNLLNDLYTIFDGIIEKHDVYKVETIGDGYLCVSGLPHRNGN 959
Query: 979 DHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTV 1038
+H +A M+L L FRV HLP ++LRIG++ G AGVVGLTMPR+CLFGD V
Sbjct: 960 EHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNCGSVVAGVVGLTMPRFCLFGDAV 1019
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
NTASRMES G +I +S+ L GG+ SRG IKGKG M T+WL G+
Sbjct: 1020 NTASRMESNGKPGKIHVSAEANRMLHLVGGFDTESRGEVIIKGKGVMETFWLTGQ 1074
>UniRef50_Q75V80 Cluster: Guanylate cyclase; n=11; Euteleostomi|Rep:
Guanylate cyclase - Oryzias latipes (Medaka fish)
(Japanese ricefish)
Length = 859
Score = 392 bits (964), Expect = e-107
Identities = 219/503 (43%), Positives = 298/503 (59%), Gaps = 19/503 (3%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVFDECWR 657
Y G V ++ +Q T L + + ++ L N+ FIG C+ A++ + C +
Sbjct: 327 YDGRTVAIKRIQ-TKMFSLSKTIRQEVKQVRELDHPNLCKFIGGCIEVPNIAIITEYCPK 385
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
GSL DVL+ ++I ++W FR S +D+ +GM YLH + HGRL S NCV+D RWV ++T
Sbjct: 386 GSLNDVLLNEEIPINWGFRFSFAADIARGMSYLHQHKI-CHGRLKSMNCVLDDRWVCKIT 444
Query: 718 DYGLPALHRTQGLPPAQRTPRELL--WTAPELIREAREGGGWLATQSGDVFSFAIIMQEV 775
DYGL R G P + L+ + PE E T +GDVFS++II+ E+
Sbjct: 445 DYGLRMYCRDDGTEPLSTYQQRLMEVYMPPEFQNSNME-----PTLAGDVFSYSIILLEI 499
Query: 776 IVRGEPYCMLSFTPEEIID-KLCRPPPLIRPSVSMGAAPPEA--VSVMRQCWSEAPDLRP 832
R +P E +D C P P + S + P A V ++R+C S P RP
Sbjct: 500 ATRNDPVP----AEESSLDCGWCPPLPELISSKTDNTCPCPADYVDLIRRCRSHNPAHRP 555
Query: 833 DFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRM 892
F ++ ++ K++ VD M ++EKYS +LE L+ ERT+ L EK+KT++LL M
Sbjct: 556 TFEQIKKFVHRINP-IKVSPVDMMMNLMEKYSKHLEVLVAERTQDLTHEKQKTDRLLYSM 614
Query: 893 LPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAI 952
LP+ VA+ L G + + + +++FSDIVGFT L++ ST QVVD LN LYTTFD I
Sbjct: 615 LPKQVADDLRQGKPSQAQSYVSATVFFSDIVGFTQLSSSSTPYQVVDFLNKLYTTFDNII 674
Query: 953 EQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLR 1011
+ Y VYKVETIGDAYMVV G+PQ HA +A+MAL L+ + FR+ H P L +R
Sbjct: 675 DNYDVYKVETIGDAYMVVSGVPQENGILHASEIASMALDLVGVCRTFRIPHKPSMQLQIR 734
Query: 1012 IGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKL 1071
G+H+GP AGVVG MPRYCLFGDTVNTASRMEST A +IQ SS+T L GGY L
Sbjct: 735 AGIHSGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSTALKIQCSSSTFYLLEEIGGYVL 794
Query: 1072 RSRGLTQIKGKGAMHTYWLLGKE 1094
RG+ Q+KGKG M TYWL GK+
Sbjct: 795 ECRGVQQVKGKGDMVTYWLQGKK 817
>UniRef50_Q18331 Cluster: Guanylyl cyclase protein 11; n=2;
Caenorhabditis|Rep: Guanylyl cyclase protein 11 -
Caenorhabditis elegans
Length = 1032
Score = 390 bits (961), Expect = e-107
Identities = 214/508 (42%), Positives = 308/508 (60%), Gaps = 14/508 (2%)
Query: 592 VVDRRI-RYKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPAL 650
+VD + +Y+ V +R + T L+L R+ + L+ N EN+N F G + E
Sbjct: 496 IVDWHLAKYENTLVTVRKINKT-QLKLTREMKQEIDLLMNETHENLNRFFGLINESDLIF 554
Query: 651 VFDECW-RGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLH-GSPLRAHGRLSSRNCVV 708
R SL D+L DD++LD F++S + D+VKG+++LH GS + HG L S NC+V
Sbjct: 555 TIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQFLHEGSKIGYHGNLKSSNCIV 614
Query: 709 DSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIRE--AREGGGWLATQSGDVF 766
D+ W +++++YG+ + + + P +LLW APE+IR + L D++
Sbjct: 615 DAYWRIKLSNYGMEQIR----VEEPESKPDDLLWFAPEIIRRYAVKHDLSKLELAKADIY 670
Query: 767 SFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRPP--PLIRPSVSM-GAAPPEAVSVMRQC 823
S AI++ E+ R P+ +EII++L P L RP + + AP SV+ +C
Sbjct: 671 SLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDIHLITKAPYPLASVVEKC 730
Query: 824 WSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKK 883
W E P RP ++ ++ + +G K NI D++ +L++Y NNLE++I+ERTEQL+ E+K
Sbjct: 731 WVEDPASRPSIQKVRELLEPLSKGLKGNIADNIMNLLDRYRNNLEDVIKERTEQLEDERK 790
Query: 884 KTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLND 943
+ E LL ++LP+SVA L G V+ E ++ VSIYFSDIVGFTAL+++ST +QVV++LN+
Sbjct: 791 RNESLLLQLLPKSVANSLKNGQPVDAEFYDSVSIYFSDIVGFTALSSKSTPLQVVNMLNN 850
Query: 944 LYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ-RTRDHAESVATMALHLLHLAGRFRVRH 1002
LYT FD I+++ YKVETIGDAYM V GLP+ + HA VA+ +L LL F V H
Sbjct: 851 LYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEVNSYLHAGEVASASLELLDSIKTFTVSH 910
Query: 1003 LPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEK 1062
PD L LRIG HTGP GVVG+ MPRYCLFGDTV A+ MES+G RIQISS E
Sbjct: 911 CPDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPMRIQISSDAYEL 970
Query: 1063 LLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
+L GGY R +K K + TYW+
Sbjct: 971 ILKCGGYVTEQREKIVLKNKLEVMTYWM 998
>UniRef50_O16715 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1119
Score = 382 bits (940), Expect = e-104
Identities = 207/506 (40%), Positives = 295/506 (58%), Gaps = 12/506 (2%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPA-LVFDECWR 657
Y+G V L+ + +E R + +Q NV F+G + + +V++ R
Sbjct: 514 YEGRTVALKRIY-RSDVEFTRSIRLEIAKLQESVNSNVIEFVGMVVQSPDVFVVYELAQR 572
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
GSL+D+L DD+ LD FR + D++ G+ YLH SP+ HGRL S NC++D+RW++R++
Sbjct: 573 GSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHSSPIGCHGRLKSTNCLIDARWMVRLS 632
Query: 718 DYGLPALH--RTQGLPPAQRTPRELLWTAPELIREAR--EGGGWLATQSGDVFSFAIIMQ 773
+GL L T + ++ LWT+PEL+R + G L Q DV+S AI++
Sbjct: 633 SFGLRELRGEETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLLVQKSDVYSLAIVLY 692
Query: 774 EVIVRGEPYCMLSFTPEEIIDKLCRPPPL----IRPSVSMGAAPPEAVS-VMRQCWSEAP 828
E+ R P+ P EI+ + R RP +++ P V + W+E P
Sbjct: 693 ELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQETVVAAWTEDP 752
Query: 829 DLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQL 888
RP +++ + + G K I+D+M M+EKY++ LE+ I ER E+L+ EK K+E L
Sbjct: 753 LNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEGEKAKSEAL 812
Query: 889 LNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTF 948
L MLP VA+ L LGS V E FE +++FSD GF ++A S + +V LNDLYT F
Sbjct: 813 LKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFLNDLYTVF 872
Query: 949 DAAIEQYRVYKVETIGDAYMVVGGLP-QRTRDHAESVATMALHLLHLAGRFRVRHLPDTP 1007
D I+Q+ VYKVETI DAYMV GLP HA +A++ L LL F++RHLP+
Sbjct: 873 DRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFKIRHLPNEK 932
Query: 1008 LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAG 1067
+ LRIG+++GPC AGVVGL MPRYCLFGDTVNTASRMES G RI S T E L G
Sbjct: 933 VRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLG 992
Query: 1068 GYKLRSRGLTQIKGKGAMHTYWLLGK 1093
GY++ RG+ ++KGKG TY++ G+
Sbjct: 993 GYEIEERGIVEMKGKGKQMTYFVRGE 1018
>UniRef50_Q4RYJ0 Cluster: Guanylate cyclase; n=2; Tetraodontidae|Rep:
Guanylate cyclase - Tetraodon nigroviridis (Green puffer)
Length = 510
Score = 381 bits (938), Expect = e-104
Identities = 219/513 (42%), Positives = 300/513 (58%), Gaps = 48/513 (9%)
Query: 628 MQNLRQENVNPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKG 686
M+ ++ EN+ F G C+ LV C +GSL+DVL D++LD F+LS D+V G
Sbjct: 1 MKEMKHENLVQFFGVCIEPPNVCLVMQYCRKGSLKDVLRDSDVELDGIFKLSFAYDIVNG 60
Query: 687 MRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALH---RTQGLPPAQRTPRELLWT 743
M ++H S LR+HG L C+VDSR ++++ +GL R Q ++ WT
Sbjct: 61 MDFIHKSTLRSHGNLKPSTCLVDSRLQIKLSGFGLCEFKYGTRNQINLEENTNYSDMYWT 120
Query: 744 APELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGE--PYCMLSFTPEEIIDKLCRP-- 799
APEL+R+ GG T GD++SFAII+ E+ + PY L+ P+EII +L P
Sbjct: 121 APELLRKV--GGPVGGTPKGDIYSFAIILWEIQYNSKSGPYQDLNLEPKEIIGQLRAPLQ 178
Query: 800 -PPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFE 858
PL RP ++ + ++R CWSE PD RP F + R NI+D+M E
Sbjct: 179 GEPL-RPLLNGELCEEKINHLLRACWSENPDHRPPFGSIRRQLRDTCPDSHANILDNMVE 237
Query: 859 MLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIY 918
LEKY+N+LEE++ +RT QL EK +TE+LL+ MLP+ +A++LM G VEP+ + V+++
Sbjct: 238 KLEKYANHLEEVVEDRTNQLTAEKIRTEKLLSSMLPKYIADQLMAGKSVEPQSYNLVTVF 297
Query: 919 FSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLP-QRT 977
FSDIVGFT++ A S+A++VV LNDLY+ FD I Y VYKVETIGDAYMV G+P
Sbjct: 298 FSDIVGFTSMCALSSALEVVSFLNDLYSLFDDIIRMYDVYKVETIGDAYMVASGVPIANG 357
Query: 978 RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT--------------------- 1016
HA ++TMALH L F++ H+P L +RIG+H+
Sbjct: 358 NKHAIEISTMALHFLSSIKVFKIHHMPTETLAIRIGIHSGGTRAAEVTNRRSGATETVGF 417
Query: 1017 -GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRG 1075
GP AGVVG MPRYCLFGDTVN ASRMES +A +I +S TA+ LL AG ++L RG
Sbjct: 418 VGPVVAGVVGTAMPRYCLFGDTVNMASRMESNSSALKIHVSQRTADILLQAGSFELEERG 477
Query: 1076 LTQIK-------------GKGAMHTYWLLGKEG 1095
+IK GKG+ TYWLL K+G
Sbjct: 478 EIEIKVREGSRHPEKPPHGKGSHKTYWLLNKQG 510
>UniRef50_O96993 Cluster: Guanylate cyclase; n=1; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1151
Score = 380 bits (936), Expect = e-103
Identities = 204/477 (42%), Positives = 299/477 (62%), Gaps = 19/477 (3%)
Query: 628 MQNLRQENVNPFIGCLCEGRPAL--VFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVK 685
++ L +N+N G +C P L ++ C RG+L++++ + D +L+ D+
Sbjct: 666 LRQLDHDNMNKLYG-VCTDGPLLFAIWRNCQRGTLKELIAKEQYVGDNCVMFALMRDIAN 724
Query: 686 GMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAP 745
G+ +H S + AHG LSS NC+++ RW ++++D+GL + +Q L + + LLWTAP
Sbjct: 725 GLLAIHQSFIGAHGLLSSENCLINDRWQVKISDFGLNMIRESQTL-----SKKALLWTAP 779
Query: 746 ELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPE--EIIDKLCRPPPLI 803
EL+RE G + GDVFSFAII E++ R + + + EI+ +L R I
Sbjct: 780 ELLRENNRKGA----KEGDVFSFAIICVEMMNRETVWNGVERDQDIDEILYRLRRTNTTI 835
Query: 804 --RPSVSMGAAPPEAV-SVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEML 860
RP + A +++ ++R CWSE P RP + + + +QM + N++D +F ML
Sbjct: 836 PHRPQLHPRAEINQSLLHLIRDCWSEVPSERPRMDIVRTMLKQMVQDGSQNLMDYVFGML 895
Query: 861 EKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFS 920
E+Y+++LE+ + ERT++L EK+K++ LL RMLPR VA++L +G VEPE F+ +I+FS
Sbjct: 896 EQYASSLEQEVEERTKELVEEKRKSDILLYRMLPRQVADKLKIGESVEPESFQMATIFFS 955
Query: 921 DIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD- 979
D+V FT LA + + +QVV+LLN L+T FD I+ + YKVETIGD Y+V G+P+R D
Sbjct: 956 DVVSFTTLAGKCSPLQVVNLLNGLFTAFDGIIDTHDCYKVETIGDGYLVCSGIPKRNGDQ 1015
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
HA+ +A ++ L FRV HLP ++LRIG H+GP AGVVGLTMPRYCLFGD+VN
Sbjct: 1016 HAKEIAELSFAFLRTVSSFRVDHLPSERVNLRIGFHSGPAVAGVVGLTMPRYCLFGDSVN 1075
Query: 1040 TASRMESTGAAWRIQISSTTAEKLLAA-GGYKLRSRGLTQIKGKGAMHTYWLLGKEG 1095
TASRMES G A R+ ISS+ L + GGY RG IKGKG M T+WLLG+ G
Sbjct: 1076 TASRMESNGKAGRVHISSSANHFLTSVIGGYVTEPRGEVIIKGKGVMETFWLLGRIG 1132
>UniRef50_Q9GT36 Cluster: Guanylate cyclase; n=1; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1112
Score = 378 bits (930), Expect = e-103
Identities = 199/477 (41%), Positives = 295/477 (61%), Gaps = 16/477 (3%)
Query: 625 LLLMQNLRQENVNPFIGCLCEGRPAL-VFDECWRGSLEDVLM-ADDIKLDWTFRLSLLSD 682
L M+ L +NVN FIG +G L ++ C RG L DV+ + + +D F SL+ D
Sbjct: 627 LRTMRLLDGDNVNRFIGLSIDGAALLSLWRYCSRGPLSDVISGSSSLTMDGFFIYSLVRD 686
Query: 683 LVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLW 742
+ +G+R+LH S + +G L S NC++D RW ++++++GL + +R ++L+W
Sbjct: 687 VAEGLRFLHASSIGWYGNLRSTNCLIDDRWQIKLSEFGLRFFRAHE-----KREAKDLVW 741
Query: 743 TAPELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPL 802
TAPEL+R+ + + GDV+SF+I+ E IV +P +
Sbjct: 742 TAPELLRD----NDIVGNKFGDVYSFSIVSSE-IVNMKPIWEQDEAKGNVERVRTGGKRA 796
Query: 803 IRPSVSMGAAP--PEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEML 860
RP + + P + +++ CW E+P RP + + + M GR N++D +F ML
Sbjct: 797 FRPKLEPSSQDLSPALLHLIKDCWDESPAERPKMETVTALLQSMNTGRSTNLMDHVFNML 856
Query: 861 EKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFS 920
E Y+ +LEE + ERT++L EKKKT+ LL RMLP+ VA++L LG VEPE F+ V+++FS
Sbjct: 857 EVYAGSLEEEVEERTKELVEEKKKTDILLYRMLPKQVADKLKLGQSVEPETFDCVTVFFS 916
Query: 921 DIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-RD 979
D+V FT +A++ + +QVV+LLN+LYT D+ I ++ VYKVETIGD Y+ V GLP R +
Sbjct: 917 DVVSFTTIASKCSPLQVVNLLNNLYTLLDSIIAEFDVYKVETIGDGYLCVSGLPHRNGHE 976
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
HA+ +A M+L + G F + HLP L LRIG+HTG AGVVGL+MPRYCLFGDT+N
Sbjct: 977 HAQHIAKMSLAFMRNLGSFTIPHLPIERLRLRIGIHTGSTVAGVVGLSMPRYCLFGDTIN 1036
Query: 1040 TASRMESTGAAWRIQISSTTAEKLL-AAGGYKLRSRGLTQIKGKGAMHTYWLLGKEG 1095
TA+R+ES+ RI IS+TT L+ GG+ ++RG +KGKG + T+WLLG EG
Sbjct: 1037 TAARLESSSKPMRIHISTTTNHFLVNVLGGFVTQARGEILVKGKGVLETFWLLGLEG 1093
>UniRef50_Q09435 Cluster: Guanylate cyclase receptor-type gcy-1
precursor; n=5; Caenorhabditis|Rep: Guanylate cyclase
receptor-type gcy-1 precursor - Caenorhabditis elegans
Length = 1137
Score = 375 bits (922), Expect = e-102
Identities = 202/489 (41%), Positives = 295/489 (60%), Gaps = 18/489 (3%)
Query: 617 LKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPAL-VFDECWRGSLEDVLMADDIKLDWTF 675
L + + + M+ L EN+N FIG + + V C RGSL+D+L + +D+ F
Sbjct: 600 LTKADKERFVKMRKLDHENINRFIGLSIDSAHFISVTKLCSRGSLQDILSRGNFSMDYFF 659
Query: 676 RLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQR 735
++ D+ KG+ YLH + LR HG L S C+V+ W +++ +YG+ L Q PP +R
Sbjct: 660 MFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQ-TPPKKR 718
Query: 736 TPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTP--EEII 793
LLW APE++R + S D++SFAII E++ + E + +L EEI+
Sbjct: 719 ----LLWVAPEVLRGSLSVSQM--EPSADIYSFAIIASEILTKKEAWDILDRKEDCEEIV 772
Query: 794 DKLCRPPPL-IRPSV--SMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKI 850
+ + IRP + + P +++++ CW+E P+ RP + + + +K
Sbjct: 773 YNVKKGGLFPIRPEIITDIHDVNPALIALVKDCWAEVPEDRPTAENICSQMKGLVSKQKT 832
Query: 851 NIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPE 910
N++D +F MLE+Y++ LEE I ERT++L +EKKK + LL+RMLP+ VAERL G VEPE
Sbjct: 833 NLMDHVFNMLEEYTSTLEEEIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQTVEPE 892
Query: 911 EFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVV 970
F+ V+++FSD+V FT LA++ + Q V+LLNDLY+ FD IEQ+ VYKVE+IGD Y+ V
Sbjct: 893 GFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDLYSNFDTIIEQHGVYKVESIGDGYLCV 952
Query: 971 GGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMP 1029
GLP R H + + M+L + F + HLP + LRIG+++GPC AGVVGL+MP
Sbjct: 953 SGLPTRNGYAHIKQIVDMSLKFMEYCKSFNIPHLPRENVELRIGVNSGPCVAGVVGLSMP 1012
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAA---GGYKLRSRGLTQIKGKGAMH 1086
RYCLFGDTVNTASRMES G I +++ A LL Y+ SRG IKGKG M
Sbjct: 1013 RYCLFGDTVNTASRMESNGKPSLIHLTN-DAHSLLTTHYPNQYETSSRGEVIIKGKGVME 1071
Query: 1087 TYWLLGKEG 1095
T+W+ G+ G
Sbjct: 1072 TFWVHGRFG 1080
>UniRef50_Q4T7P7 Cluster: Chromosome undetermined SCAF8055, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF8055,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 1071
Score = 373 bits (917), Expect = e-101
Identities = 203/415 (48%), Positives = 270/415 (65%), Gaps = 30/415 (7%)
Query: 574 VTARVPSAPSSTCSVNRVVVDRRIRYKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQ 633
++ R +P ST S + Y+GD L+ L + K+++V LM+++R
Sbjct: 504 ISERSVVSPVSTKSPATHENSNVVIYEGDWAWLKRLLDGRFSNISPKTSNVFELMKDMRH 563
Query: 634 ENVNPFIGCLCE-GRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHG 692
ENVNPF+G + G A+V + C RGSLED+L DD+KLDW F+ SLL DL+KGM+YLH
Sbjct: 564 ENVNPFLGFFHDCGLFAIVTEFCSRGSLEDLLQNDDVKLDWMFKSSLLLDLIKGMKYLHH 623
Query: 693 SPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAR 752
+ +H RL SRNCVVD R+VL++TDYG + Q P + ELLWTAPE++R
Sbjct: 624 RGV-SHSRLKSRNCVVDGRFVLKITDYGFNEVLDAQRFPYTEPPEDELLWTAPEILRMPG 682
Query: 753 EGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLS----FTPEEIIDKLCRPPPLIRPSVS 808
+ G + T GDV+SFAIIMQEV++RG P+C L+ F EI++KL +PPPL RP VS
Sbjct: 683 QPGVY-GTLPGDVYSFAIIMQEVVIRGPPFCTLNLIQCFYVLEILEKLRKPPPLCRPVVS 741
Query: 809 MGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLE 868
AP E + +M+QCWSE PD RP F+ + D F+ + +G+K NI+DSM MLE+YS+NLE
Sbjct: 742 PDYAPLECIQLMKQCWSEQPDKRPAFDEIFDQFKNINKGKKTNIIDSMLRMLEQYSSNLE 801
Query: 869 ELIRERTEQLDMEKKKTEQLLNRMLP-----------------------RSVAERLMLGS 905
ELIRERTE+L++EK+KTE+LL +MLP RSVAE L +G
Sbjct: 802 ELIRERTEELEIEKQKTEKLLTQMLPPCVNADEPNQSVHLHGSASSSPFRSVAEALKVGG 861
Query: 906 RVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKV 960
VEPE F V+IYFSDIVGFT ++A S ++VVDLLN+LYT FDA I + VYKV
Sbjct: 862 IVEPEHFGSVTIYFSDIVGFTTISANSEPIEVVDLLNNLYTIFDAIIGNHDVYKV 916
>UniRef50_Q19768 Cluster: Guanylate cyclase; n=2; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1025
Score = 372 bits (916), Expect = e-101
Identities = 216/511 (42%), Positives = 309/511 (60%), Gaps = 38/511 (7%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPALVFDE-CWR 657
Y + V R Q+ + + ++ L +++++ +NVN FIG +G + F C R
Sbjct: 530 YMNEPVLARKYQLR--VPIFKQDRSELRMLRSIEHDNVNRFIGLSIDGPVYMSFWRYCSR 587
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVK-------GMRYLHGSPLRAHGRLSSRNCVVDS 710
GS++DV+ I +D F L+ D+ G++Y+H SP++ HG L+S C ++
Sbjct: 588 GSIKDVIAKSSINMDGFFIYCLIKDIASVSRHENPGLQYIHHSPIKQHGSLTSECCYIND 647
Query: 711 RWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAI 770
RW +++ YGL + QG+ +RT LL TAPE++RE G TQ+GDV+SF+I
Sbjct: 648 RWQVKIGSYGLSFM---QGVE--KRTEDGLLHTAPEVLREGLTSG----TQAGDVYSFSI 698
Query: 771 IMQEVIVRGEPYCMLSFTPE--EIIDKLCRPPPL-IRPSVSM--GAAPPEAVSVMRQCWS 825
+ E++ + + + E EII + R RPS+ P + ++R CW
Sbjct: 699 VCSELVGHSSAWNLENRKEEADEIIFMVKRGGRTPFRPSLDDVDDDINPAMLHLIRDCWD 758
Query: 826 EAPDLRPDFNRLHDVFRQMQRGRK--INIVDSMFEMLEKYSNNLEELIRERTEQLDMEKK 883
E P RP+ + ++ + + M GR N++D +F +LEK++++LE+ ++ER ++L EKK
Sbjct: 759 EDPKQRPNIDMVNKLMKNMNSGRSGSANLMDHVFSVLEKHASSLEDEVQERMKELVEEKK 818
Query: 884 KTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLND 943
K++ LL RMLP+ VAERL LG VEPE FE V+I+FSD+VGFT VV+LLND
Sbjct: 819 KSDILLYRMLPQQVAERLKLGQSVEPEAFESVTIFFSDVVGFT----------VVNLLND 868
Query: 944 LYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRH 1002
LYTTFDA IE+ YKVETIGDAY+VV GLP+R +H ++A M+L L+ F++ H
Sbjct: 869 LYTTFDAIIEKNDSYKVETIGDAYLVVSGLPRRNGTEHVANIANMSLELMDSLQAFKIPH 928
Query: 1003 LPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEK 1062
LP + +RIG+H+G C AGVVGLTMPRYCLFGDTVNTASRMES G I +SS +
Sbjct: 929 LPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLSSDCYDL 988
Query: 1063 LLAA-GGYKLRSRGLTQIKGKGAMHTYWLLG 1092
L + Y SRG IKGKG M TYWLLG
Sbjct: 989 LTSLYKEYNTESRGEVIIKGKGVMQTYWLLG 1019
>UniRef50_P25092 Cluster: Heat-stable enterotoxin receptor precursor;
n=41; Euteleostomi|Rep: Heat-stable enterotoxin receptor
precursor - Homo sapiens (Human)
Length = 1073
Score = 368 bits (905), Expect = e-100
Identities = 203/459 (44%), Positives = 279/459 (60%), Gaps = 33/459 (7%)
Query: 651 VFDECWRGSLEDVL-----MADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRN 705
V + C RGSL +VL D +DW F++S+L D+ KGM YLH S HGRL S N
Sbjct: 560 VIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTN 619
Query: 706 CVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDV 765
CVVDSR V+++TD+G ++ LPP ++ LWTAPE +R+A +Q GDV
Sbjct: 620 CVVDSRMVVKITDFGCNSI-----LPP-----KKDLWTAPEHLRQAN------ISQKGDV 663
Query: 766 FSFAIIMQEVIVRGEPYCMLSFTPE-EIIDKLCRPPPL--IRPSVSMGAAPPEAVSV--- 819
+S+ II QE+I+R E + LS E I ++ + RP + + A + + V
Sbjct: 664 YSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLL 723
Query: 820 MRQCWSEAPDLRPDFNRLHD----VFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERT 875
++ CW E P+ RPDF ++ +F + + +D++ L+ YS NLE L+ ERT
Sbjct: 724 VKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERT 783
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAV 935
+ E+ + ++L +LPR V + L VEPE +EEV+IYFSDIVGFT + ST +
Sbjct: 784 QLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPM 843
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHL 994
+VVD+LND+Y +FD ++ + VYKVETIGDAYMV GLP+R + HA +A MAL +L
Sbjct: 844 EVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSF 903
Query: 995 AGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQ 1054
G F + HLP P+ +RIG+H+GPC AGVVG+ MPRYCLFGDTVNTASRMESTG RI
Sbjct: 904 MGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIH 963
Query: 1055 ISSTTAEKLLAAG-GYKLRSRGLTQIKGKGAMHTYWLLG 1092
+S +T L + RG T +KG+G TYWL G
Sbjct: 964 VSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002
>UniRef50_Q9XVV4 Cluster: Guanylate cyclase; n=2; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1161
Score = 360 bits (885), Expect = 2e-97
Identities = 202/492 (41%), Positives = 289/492 (58%), Gaps = 39/492 (7%)
Query: 628 MQNLRQENVNPFIGCLCEGRPAL--VFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVK 685
M+ + N+N FIG + P L V+ C RGSL DV+ +++D F SL+ D++
Sbjct: 665 MRLIDHANLNKFIGMSLDA-PQLYSVWRFCSRGSLADVIRKASMQMDGFFIYSLMKDIIN 723
Query: 686 GMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAP 745
G+ ++H S HG L+S+NC+++ RW L++TD+GL + RT Q + LWT+P
Sbjct: 724 GLTWIHESSHEFHGMLTSKNCLLNDRWQLKITDFGL-RIFRTHD----QYNKSDRLWTSP 778
Query: 746 ELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTP--EEIIDKLCR----- 798
EL+R L ++ GD++SF II E+I R + + + EEII L +
Sbjct: 779 ELLRT----DDILGSREGDIYSFGIISAELITRSSVFDLENRKEDAEEIIYMLKKGGLQS 834
Query: 799 PPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFE 858
P P + S+ P + ++R CW+E P RPD ++ R M R N++D +F
Sbjct: 835 PRPSLEHDESI-EINPALLHLVRDCWTERPSERPDIKQVASQLRSMNTNRNDNLMDHVFN 893
Query: 859 MLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIY 918
+LE Y++ LE+ + ER ++L EKKK++ LL RMLPR VA++L LG VEPE F+ V+++
Sbjct: 894 VLESYASTLEDEVAERMKELVEEKKKSDVLLYRMLPRQVADKLKLGQTVEPETFDIVTLF 953
Query: 919 FSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT- 977
FSD+V FT LA + T +QVV+LLN LYT FD IEQ+ VYKVETIGD Y V G+P+R
Sbjct: 954 FSDVVSFTTLAGKCTPLQVVNLLNGLYTIFDGIIEQHDVYKVETIGDGYFVASGVPRRNG 1013
Query: 978 RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDT 1037
+H ++A+M+++ + F + HLP + +R+G H G AGVVGLTMPRYCLFGD
Sbjct: 1014 NEHTRNIASMSINFVKSLADFSIPHLPGEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDA 1073
Query: 1038 VNTASRMESTG------------------AAWRIQISSTTAEKLLAAGGYKLRSRGLTQI 1079
VNTASRMES +A +I +S + L+ GG+ RG I
Sbjct: 1074 VNTASRMESNSKRKIFQKSTNISSSFHLFSAGQIHLSEEANQMLMRLGGFTTEPRGEVII 1133
Query: 1080 KGKGAMHTYWLL 1091
KGKG M TYWLL
Sbjct: 1134 KGKGVMATYWLL 1145
>UniRef50_Q10029 Cluster: Guanylate cyclase; n=1; Caenorhabditis
elegans|Rep: Guanylate cyclase - Caenorhabditis elegans
Length = 1118
Score = 359 bits (884), Expect = 2e-97
Identities = 196/481 (40%), Positives = 285/481 (59%), Gaps = 33/481 (6%)
Query: 617 LKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPALVFDE-CWRGSLEDVLMADDIKLDWTF 675
L + + + M+ L EN+N FIG + + + C RGSL+D+L + +D+ F
Sbjct: 601 LTKADKERFVKMRKLDHENINRFIGLSIDSAHFIAVTKLCSRGSLQDILSRGNFSMDYFF 660
Query: 676 RLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQR 735
++ D+ KG+ YLH + LR HG L S C+V+ W +++ +YG+ L Q PP +R
Sbjct: 661 MFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQ-TPPKKR 719
Query: 736 TPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDK 795
LLW APE++R + S D++SFAII E++ + E + +I+D+
Sbjct: 720 ----LLWVAPEVLRGSLSVSQM--EPSADIYSFAIIASEILTKKEAW--------DILDR 765
Query: 796 LCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDS 855
LI ++++ CW+E P+ RP + + + +K N++D
Sbjct: 766 KEDCEALI--------------ALVKDCWAEVPEDRPTAENICSQMKGLVSKQKTNLMDH 811
Query: 856 MFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEV 915
+F MLE+Y++ LEE I ERT++L +EKKK + LL+RMLP+ VAERL G VEPE F+ V
Sbjct: 812 VFNMLEEYTSTLEEEIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSV 871
Query: 916 SIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ 975
+++FSD+V FT LA++ + Q V+LLNDLY+ FD IEQ+ VYKVE+IGD Y+ V GLP
Sbjct: 872 TVFFSDVVKFTILASKCSPFQTVNLLNDLYSNFDTIIEQHGVYKVESIGDGYLCVSGLPT 931
Query: 976 RT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLF 1034
R H + + M+L + F++ HLP + LRIG+++GPC AGVVGL+MPRYCLF
Sbjct: 932 RNGYAHIKQIVDMSLKFMEYCRSFKIPHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLF 991
Query: 1035 GDTVNTASRMESTGAAWRIQISSTTAEKLLA--AGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
GDTVNTASRMES G I ++S LL Y SRG IKGKG M T+W+ G
Sbjct: 992 GDTVNTASRMESNGKPSLIHLTSDAHLLLLTHYPNHYDTSSRGEVIIKGKGVMETFWVHG 1051
Query: 1093 K 1093
+
Sbjct: 1052 R 1052
>UniRef50_O16544 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1143
Score = 353 bits (867), Expect = 2e-95
Identities = 200/494 (40%), Positives = 290/494 (58%), Gaps = 31/494 (6%)
Query: 617 LKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPAL-VFDECWRGSLEDVLMADDIKLDWTF 675
L R D + ++ L ENVN F+G +G L V+ C RGSL+D++ + +D F
Sbjct: 563 LIRTDYDTFVRLRKLDHENVNKFVGMSIDGPEYLAVWKLCMRGSLQDIIGQGNFSIDPFF 622
Query: 676 RLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQR 735
++ D+ +G++YLH S L H L S +V+ W ++TD+GL L + +
Sbjct: 623 MFCVIRDMAEGLKYLHNSFLHVHANLRSGTVLVNESWQAKLTDFGLGTLAEEK-----KP 677
Query: 736 TPRELLWTAPELIREAREGGGWLATQ---SGDVFSFAIIMQEVIVRGEPYCMLSF--TPE 790
R LW APE+IR G L Q S D++S A+I EV+ R E + M T +
Sbjct: 678 MKRRQLWMAPEVIR-----GTLLPHQIEKSADIYSLAVIASEVLTRKEAWNMAERKDTVD 732
Query: 791 EIIDKLCRPPPLI-RPSVSMGAAP--PEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRG 847
EI+ ++ + P RP + M + ++R CWSE P RP + + ++ + M
Sbjct: 733 EIVYRIKKGGPNAPRPELDMDGVEINHNLLILIRDCWSEEPADRPSADVICNLLKNMMP- 791
Query: 848 RKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRV 907
+K N++D +F +LE Y+ NLE + +RT++L EKKK + LL RMLP+ VAERL G V
Sbjct: 792 KKGNLMDHVFNILEDYTTNLEVEVEDRTKELTAEKKKADVLLGRMLPKQVAERLKQGQTV 851
Query: 908 EPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAY 967
EPE F+ V+++FSD+V FT LAA+ + QVV+LLNDLY+ FDA IE++ YKVE+IGD Y
Sbjct: 852 EPEGFDSVTVFFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDAIIEEHGCYKVESIGDGY 911
Query: 968 MVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGL 1026
+ V GLP + + H + + ++L + F++ HLP + LRIG+++GPC AGVVGL
Sbjct: 912 LCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPHLPREKVELRIGVNSGPCVAGVVGL 971
Query: 1027 TMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAA----------GGYKLRSRGL 1076
+MPRYCLFGDTVNTASRMES G ++ + S++ L AA Y SRG
Sbjct: 972 SMPRYCLFGDTVNTASRMESNGKGRQMALKSSSHIHLSAASYTLLMKHYPNQYNTASRGD 1031
Query: 1077 TQIKGKGAMHTYWL 1090
IKGKG M T+W+
Sbjct: 1032 VIIKGKGVMETFWV 1045
>UniRef50_Q2L6K6 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1113
Score = 322 bits (792), Expect = 3e-86
Identities = 184/508 (36%), Positives = 290/508 (57%), Gaps = 34/508 (6%)
Query: 619 RKSTDVLLLMQNLRQENVNPFIGCLCEGRPALV--FDECWRGSLEDVLMADDIKLDWTFR 676
++ +L M+ +N+NPF+G + ++ + C RG+++D++ ++ LD F
Sbjct: 595 KEDMQLLTQMKQAVHDNLNPFLGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFH 654
Query: 677 LSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLP-ALHR--TQG---L 730
+ + D+ G+ YLH SP+ HG L+ C++D W+++++DYG+ L R QG +
Sbjct: 655 GAFVRDITLGLEYLHASPIGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGAIEI 714
Query: 731 PPAQRTPRE--------LLWTAPELI--REAREGGG----W-----LATQSGDVFSFAII 771
A+ + + +++ APEL+ RE + G W L Q+GD++SF ++
Sbjct: 715 AAAKDSDDKSQASQATSIIYMAPELLKNRETNKRRGMDQSWVKQSMLRRQAGDIYSFGMV 774
Query: 772 MQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSVS--MGAAPPEAVSVMRQCWSEAPD 829
M E++ R P+ + E++D L + P + MG P + +++R CWSE P+
Sbjct: 775 MYEILFRSLPF-RDNTNISELVDYLADGSKTVSPEIQNQMGLHP-DLNALLRDCWSENPE 832
Query: 830 LRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLL 889
+RP R+ + +M K ++VD M +M+E+Y+NNLE+L+ ERT L+ + +QLL
Sbjct: 833 IRPSIRRVR-LNTEMVLKTKGSLVDQMMKMMEQYANNLEKLVAERTGMLEEANIRADQLL 891
Query: 890 NRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFD 949
++LP VA L +G V P+ + +I FSDIVGFT + + ST ++VV++LN LYT FD
Sbjct: 892 TQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSGSTPLEVVNMLNGLYTGFD 951
Query: 950 AAIEQYRVYKVETIGDAYMVVGGLPQRTR-DHAESVATMALHLLHLAGRFRVRHLPDTPL 1008
I + + YKVETIGDAYMVV G+P+ +H+ ++A AL + +++ H P +
Sbjct: 952 ECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYLTGYQIPHRPTHRV 1011
Query: 1009 HLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGG 1068
R G HTG AGVVGLT PRYCLFGDTVN +SRMESTG IQ+S + A
Sbjct: 1012 RCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRAHHP 1071
Query: 1069 -YKLRSRGLTQIKGKGAMHTYWLLGKEG 1095
+ RG Q+KGKG T+WL + G
Sbjct: 1072 VFTTTERGEVQVKGKGTCRTFWLEDRVG 1099
>UniRef50_Q2L6K5 Cluster: Guanylate cyclase; n=3; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1073
Score = 322 bits (792), Expect = 3e-86
Identities = 178/508 (35%), Positives = 288/508 (56%), Gaps = 36/508 (7%)
Query: 619 RKSTDVLLLMQNLRQENVNPFIGCLCEGRPALV--FDECWRGSLEDVLMADDIKLDWTFR 676
R+ +L M+ +N+NPF+G + +V + C RG+++D++ ++ LD F
Sbjct: 555 RQDLQLLNQMKQAVHDNLNPFLGMSFNEKEEMVVLWKFCSRGTIQDMIYNQEVSLDSKFH 614
Query: 677 LSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLP---------ALHRT 727
+ + D+ G+ YLH S + HG L+ +C++D W++++TDYG+ L T
Sbjct: 615 GAFIRDITLGLEYLHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLIST 674
Query: 728 QGLPP-------AQRTPRELLWTAPELI------REAREGGGWLAT-----QSGDVFSFA 769
+ L AQ+T LL+ PE++ R R W+ Q GD+++F
Sbjct: 675 ETLKEGDDKSGSAQKT--SLLYQPPEMLKNKESNRTRRMDQSWVKQSQARRQMGDIYAFG 732
Query: 770 IIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSV-SMGAAPPEAVSVMRQCWSEAP 828
++M E++ R P+ E++D + RP+V P+ V+++ CW+E P
Sbjct: 733 MVMHEILFRALPFPN-GTNVSEVMDYIRDGTKTFRPTVHDRTQIHPDLVALLLDCWNENP 791
Query: 829 DLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQL 888
++RP R+ + + K ++VD M M+E+Y+NNLE+L+ ERT L+ + ++L
Sbjct: 792 EVRPSIRRVR-LNTENYLKVKGSLVDQMMRMMEQYANNLEKLVAERTGMLEEANVRADKL 850
Query: 889 LNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTF 948
L ++LP+ VA L +G V + F+ ++ FSDIVGFT + + ST ++VV +LN +Y+ F
Sbjct: 851 LGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIVGFTTICSSSTPLEVVSMLNSIYSKF 910
Query: 949 DAAIEQYRVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTP 1007
D AI ++ YKVETIGDAYM+V G+P+ +H ++ AL L+ L + + H +
Sbjct: 911 DDAINKHGSYKVETIGDAYMIVSGIPEENGNEHIRNICNTALELMLLLKTYEIPHRRNVK 970
Query: 1008 LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLA-A 1066
L +R+G+HTG AGVVGLT PRYCLFGDTVN ASRMEST +IQ+S + +
Sbjct: 971 LRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEARDFCVRYY 1030
Query: 1067 GGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
+++ RG + KGKG + +YWLLGK+
Sbjct: 1031 SEFQITLRGTVEAKGKGPVTSYWLLGKQ 1058
>UniRef50_Q2L6K7 Cluster: Recepotor type guanyly cyclase; n=1;
Caenorhabditis elegans|Rep: Recepotor type guanyly
cyclase - Caenorhabditis elegans
Length = 1152
Score = 315 bits (773), Expect = 6e-84
Identities = 185/520 (35%), Positives = 287/520 (55%), Gaps = 33/520 (6%)
Query: 603 AVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPA--LVFDECWRGSL 660
A++ +++Q + R ++ LM+ +N+NPF+G + R LV+ C RG+L
Sbjct: 589 AIYHKYVQ-RRPIVFNRADKTLIQLMKAAVHDNINPFLGMVWNEREEMLLVWKFCSRGTL 647
Query: 661 EDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYG 720
+D++ + I+LD F + + D++ G+ YLH S + HG L+ +C++D W++++TDYG
Sbjct: 648 QDIIYNESIQLDTKFHGAFIRDILAGLEYLHASQIGYHGSLTPWSCLIDRNWMIKLTDYG 707
Query: 721 LP-ALHRTQ--------GLPP----AQRTPR-ELLWTAPELI------REAREGGGWLAT 760
+ L R + GL +Q T +L+ +PE++ R R W+
Sbjct: 708 IADPLERWEKSQSISRDGLTSDDDKSQATQATSILYESPEMLKNREKNRVRRVDQDWMRQ 767
Query: 761 -----QSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSVSMGAAPPE 815
Q GDV++F ++M E+I R P+ E+++ L +++P++
Sbjct: 768 TQTRRQLGDVYAFGLVMYEIIFRALPFPE-GTNQSELVEWLRDGSKVVKPTIPQNKVLNM 826
Query: 816 AVSVMRQ-CWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRER 874
+S + Q CW+ P++RP R+ + + K ++VD M M+E+Y+NNLE+L+ ER
Sbjct: 827 DLSALIQDCWNTTPEMRPSLRRIK-LNVETYLNIKGSLVDQMTRMMEQYANNLEKLVAER 885
Query: 875 TEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTA 934
T L+ ++ ++LL+++LP VA L LG V P+ F ++ FSDIVGFT + ++
Sbjct: 886 TGMLEEANQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQNASP 945
Query: 935 VQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLH 993
++VV +LN ++ FD I + YKVETIGDAYMVV G+P+ H +A++AL +
Sbjct: 946 LEVVAVLNGIFDGFDQFIARKDAYKVETIGDAYMVVSGVPEENGHRHINEIASIALDVHK 1005
Query: 994 LAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRI 1053
F V H DT + R+G HTGP A VVGL PRYCLFGDTVN ASRMES +
Sbjct: 1006 FLSEFIVPHKRDTKVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVNMASRMESNSEPGKT 1065
Query: 1054 QISSTTAEKLLAA-GGYKLRSRGLTQIKGKGAMHTYWLLG 1092
QIS T LL Y RG IKGKG TYWL+G
Sbjct: 1066 QISETAKNLLLKEYPDYICEQRGEIPIKGKGLCMTYWLMG 1105
>UniRef50_UPI000065CD57 Cluster: Heat-stable enterotoxin receptor
precursor (EC 4.6.1.2) (GC-C) (Intestinal guanylate
cyclase) (STA receptor) (hSTAR).; n=1; Takifugu
rubripes|Rep: Heat-stable enterotoxin receptor precursor
(EC 4.6.1.2) (GC-C) (Intestinal guanylate cyclase) (STA
receptor) (hSTAR). - Takifugu rubripes
Length = 977
Score = 314 bits (771), Expect = 1e-83
Identities = 192/468 (41%), Positives = 265/468 (56%), Gaps = 60/468 (12%)
Query: 628 MQNLRQENVNPFIGCLCEGRPAL-VFDECWRGSLEDVL-----MADDIKLDWTFRLSLLS 681
+Q + N+ F G + R VF+ RGSL VL D+ +DW F++S++
Sbjct: 462 LQQIDYYNLTKFYGTVKLERGVFGVFEYGERGSLRYVLNNLVSYPDNTFMDWEFKISVMY 521
Query: 682 DLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELL 741
D+ KGM YLH S ++ HGRL S NCVVD+R V+++TD+G + +P + L
Sbjct: 522 DIAKGMSYLHSSDIQVHGRLKSTNCVVDNRMVVKITDFGCNSF----------LSPGKDL 571
Query: 742 WTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRP-P 800
WTAPE +R ++G +Q GDV+SFAII E+++R + S T +KL R
Sbjct: 572 WTAPEHLR--KQG----TSQKGDVYSFAIIAHEIVLRKCTFYTESCTKRA--EKLSRIIM 623
Query: 801 PLIRPSVSMGAAPP---EAVSVMRQCWSEAPDLRPDF----NRLHDVFRQMQRGRKINIV 853
RP ++ A E ++++ CW E P+ RPDF N L + ++ + +
Sbjct: 624 SYFRPDLNFDTASEKELEVCTLIKSCWDEDPEKRPDFRKVENYLGKIISKIHNQENESYM 683
Query: 854 DSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFE 913
D+M L+ YS NLE L+ ERT E+ + + L +LPR V + L VEPE +E
Sbjct: 684 DNMIRRLQMYSRNLEHLVEERTALYKSERDRADCLNFMLLPRPVVKSLKESGVVEPELYE 743
Query: 914 EVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKV------------- 960
EV++YFSDIVGFT L ST ++VVD+LND+Y FD ++ + VYKV
Sbjct: 744 EVTVYFSDIVGFTTLCQYSTPMEVVDMLNDIYKGFDGIVDLHDVYKVLPWATVRTLHCEL 803
Query: 961 -----------ET---IGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPD 1005
ET IGDAYMV GLP+R + HA + MAL +LH G F++RHLP
Sbjct: 804 SKCIFMPRPCKETVETIGDAYMVASGLPKRNGNRHAVDICHMALDILHFMGTFQLRHLPG 863
Query: 1006 TPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRI 1053
P+ +RIG+H+G C AGVVG+ MPRYCLFGDTVNTASRMESTG W I
Sbjct: 864 IPVWIRIGVHSGSCAAGVVGVKMPRYCLFGDTVNTASRMESTGHPWMI 911
>UniRef50_Q9GYQ4 Cluster: Guanylyl cyclase protein 8; n=3;
Caenorhabditis|Rep: Guanylyl cyclase protein 8 -
Caenorhabditis elegans
Length = 1206
Score = 312 bits (765), Expect = 5e-83
Identities = 180/489 (36%), Positives = 273/489 (55%), Gaps = 32/489 (6%)
Query: 634 ENVNPFIGCLCEGRPA--LVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLH 691
+N+NPF+G + R LV+ C RG+L+D++ + I+LD F + + D++ G+ YLH
Sbjct: 673 DNINPFLGMVWNEREEMLLVWKFCSRGTLQDIIYNESIQLDTKFHGAFIRDILAGLEYLH 732
Query: 692 GSPLRAHGRLSSRNCVVDSRWVLRVTDYGLP-ALHRTQ--------GLPP----AQRTPR 738
S + HG L+ +C++D W++++TDYG+ L R + GL +Q T
Sbjct: 733 ASQIGYHGSLTPWSCLIDRNWMIKLTDYGIADPLERWEKSQSISRDGLTSDDDKSQATQA 792
Query: 739 -ELLWTAPELI------REAREGGGWLAT-----QSGDVFSFAIIMQEVIVRGEPYCMLS 786
+L+ +PE++ R R W+ Q GDV++F ++M E+I R P+
Sbjct: 793 TSILYESPEMLKNREKNRVRRVDQDWMRQTQTRRQLGDVYAFGLVMYEIIFRALPFPE-G 851
Query: 787 FTPEEIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQ-CWSEAPDLRPDFNRLHDVFRQMQ 845
E+++ L +++P++ +S + Q CW+ P++RP R+ + +
Sbjct: 852 TNQSELVEWLRDGSKVVKPTIPQNKVLNMDLSALIQDCWNTTPEMRPSLRRIK-LNVETY 910
Query: 846 RGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGS 905
K ++VD M M+E+Y+NNLE+L+ ERT L+ ++ ++LL+++LP VA L LG
Sbjct: 911 LNIKGSLVDQMTRMMEQYANNLEKLVAERTGMLEEANQRADRLLSQLLPAYVANELKLGR 970
Query: 906 RVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGD 965
V P+ F ++ FSDIVGFT + ++ ++VV +LN ++ FD I + YKVETIGD
Sbjct: 971 PVPPKTFTSSTVLFSDIVGFTEMCQNASPLEVVAVLNGIFDGFDQFIARKDAYKVETIGD 1030
Query: 966 AYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVV 1024
AYMVV G+P+ H +A++AL + F V H DT + R+G HTGP A VV
Sbjct: 1031 AYMVVSGVPEENGHRHINEIASIALDVHKFLSEFIVPHKRDTKVQCRLGFHTGPVAAAVV 1090
Query: 1025 GLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAA-GGYKLRSRGLTQIKGKG 1083
GL PRYCLFGDTVN ASRMES + QIS T LL Y RG IKGKG
Sbjct: 1091 GLNAPRYCLFGDTVNMASRMESNSEPGKTQISETAKNLLLKEYPDYICEQRGEIPIKGKG 1150
Query: 1084 AMHTYWLLG 1092
TYWL+G
Sbjct: 1151 LCMTYWLMG 1159
>UniRef50_Q9GT37 Cluster: Guanylate cyclase; n=2; Heterodera
glycines|Rep: Guanylate cyclase - Heterodera glycines
(Soybean cyst nematode worm)
Length = 1174
Score = 305 bits (749), Expect = 5e-81
Identities = 153/296 (51%), Positives = 200/296 (67%), Gaps = 6/296 (2%)
Query: 801 PLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEML 860
P IRP++ PE + ++R CW E+P RP ++ RQM G+ IN++D +F ML
Sbjct: 839 PTIRPALDN--LNPELIHLIRDCWVESPAERPTIEKVRQKLRQMNAGQSINLMDHVFGML 896
Query: 861 EKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFS 920
E+Y+N LEE + ERT +L+ EK+K++ LL RM+PR VA L LG VEPE+FE V+++FS
Sbjct: 897 EQYANKLEEDVHERTRELEEEKRKSDILLYRMMPRQVANSLKLGQSVEPEQFECVTVFFS 956
Query: 921 DIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD- 979
DIV F AL+ + + VV+L+N+LYTTFDA ++++ VYKVE+IGD Y+ V GLP R +
Sbjct: 957 DIVQFAALSNQMRPLHVVNLMNELYTTFDAIVDEHDVYKVESIGDGYLCVSGLPNRNGNL 1016
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
HA+ A MAL L+ FR+ D + LRIGLH+GPC AGVVGL MPRYCLFGDTVN
Sbjct: 1017 HAKQCADMALKFLNSLQSFRISEHSDQRIRLRIGLHSGPCVAGVVGLAMPRYCLFGDTVN 1076
Query: 1040 TASRMESTGAAWRIQISSTTAEKL---LAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
TASRMES+ +A +I IS T L G Y SRG IKGKG M T+WLLG
Sbjct: 1077 TASRMESSSSANKIHISKETCILLHENSEGGAYLTESRGEVIIKGKGVMETFWLLG 1132
Score = 97.1 bits (231), Expect = 3e-18
Identities = 52/145 (35%), Positives = 88/145 (60%), Gaps = 8/145 (5%)
Query: 635 NVNPFIGCLCEGRPAL-VFDECWRGSLEDVLMADDIKL-DWTFRLSLLSDLVKGMRYLHG 692
N+N F+G +G L V++ C RGSL+DV+M+ + + D F S + +L +G+ +LH
Sbjct: 616 NLNRFLGLSLDGPNLLAVWNFCARGSLKDVIMSGNAMVRDVVFIQSSIRELCEGLHFLHN 675
Query: 693 SPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPELIREAR 752
SPL+ HGRL S C+++ RW ++++ +GL L TQ + ++LLW APE +R+
Sbjct: 676 SPLQFHGRLKSSACLINDRWQVKISYFGLRWLKNTQKI-----QTKDLLWLAPEQLRKMG 730
Query: 753 EGGGWL-ATQSGDVFSFAIIMQEVI 776
E + T+ D++S A+I E++
Sbjct: 731 ENKNLIDGTKQSDIYSLALIFTEMV 755
>UniRef50_Q90WX1 Cluster: Guanylyl cyclase 2; n=7; Eumetazoa|Rep:
Guanylyl cyclase 2 - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 259
Score = 303 bits (745), Expect = 1e-80
Identities = 143/214 (66%), Positives = 171/214 (79%), Gaps = 1/214 (0%)
Query: 836 RLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPR 895
R+ D F+ + +G+K NI+DSM MLE+YS+NLEELIRERTE+L++EK+KTE+LL +MLP
Sbjct: 45 RIFDQFKNVNKGKKTNIIDSMLRMLEQYSSNLEELIRERTEELEIEKQKTEKLLTQMLPP 104
Query: 896 SVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQY 955
SVAE L LG+ VEPE FE VS+YFSDIVGFT ++A S ++VVDLLNDLYTTFDA I +
Sbjct: 105 SVAEALKLGTTVEPEHFESVSLYFSDIVGFTTISANSEPIEVVDLLNDLYTTFDAVIGNH 164
Query: 956 RVYKVETIGDAYMVVGGLP-QRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGL 1014
VYKVETIGDAYMV G+P HA +A MAL +L G FR+RH+PD P+ +RIGL
Sbjct: 165 DVYKVETIGDAYMVASGVPVPNGNRHAAEIANMALDILSAVGTFRMRHMPDVPVRIRIGL 224
Query: 1015 HTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
HTGPC AGVV LTMPRYCLFGDTV TASRMESTG
Sbjct: 225 HTGPCVAGVVXLTMPRYCLFGDTVTTASRMESTG 258
Score = 63.3 bits (147), Expect = 4e-08
Identities = 28/43 (65%), Positives = 35/43 (81%), Gaps = 1/43 (2%)
Query: 678 SLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYG 720
SL+ DL+KGM+YLH + HGRL SRNCVVD R+VL++TDYG
Sbjct: 1 SLILDLIKGMKYLHHRNV-CHGRLKSRNCVVDGRFVLKITDYG 42
>UniRef50_O62026 Cluster: Putative uncharacterized protein gcy-29;
n=1; Caenorhabditis elegans|Rep: Putative uncharacterized
protein gcy-29 - Caenorhabditis elegans
Length = 1034
Score = 300 bits (737), Expect = 1e-79
Identities = 176/510 (34%), Positives = 279/510 (54%), Gaps = 35/510 (6%)
Query: 615 LELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPALV--FDECWRGSLEDVLMADDIKLD 672
+ R+ +L M+ +N+NPFIG + L+ + C RG+L+DV+ + +D
Sbjct: 517 IRFTREDLILLTKMKQAVHDNINPFIGVSFNEKSELLLLWKFCSRGTLQDVIYCEKFAMD 576
Query: 673 WTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGL--PALH----- 725
F+ + + D+ G+ YLH SP+ HG L+ + ++D W+L++TDY + P
Sbjct: 577 EKFQGAFVRDITMGLEYLHSSPIGYHGGLACWSVLIDKNWMLKLTDYAVCDPLKRWEKHG 636
Query: 726 ----RTQGLPPAQRTPRELLWTAPELIREARE------------GGGWLATQSGDVFSFA 769
+ Q L+ PE IR A E G L Q D+++F
Sbjct: 637 RINCKVDNEAEKQWQKMASLYVPPE-IRTANEKNRLKRMDQKWQGQTILKRQQSDIYAFG 695
Query: 770 IIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIRPSVSMGAA-PPEAVSVMRQCWSEAP 828
+I+ E++ R PY E+ K + +PS+ P+ +++++ CWS+ P
Sbjct: 696 VIIYEILFRSLPYDE-KVDLTELAQKAAEGDKIQKPSIQRNKKLNPDLIALLQDCWSDQP 754
Query: 829 DLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQL 888
D+RP R+ + ++ K N+VDSM M+E+Y+NNLE+L+ ERT+ + + E+L
Sbjct: 755 DMRPTIRRVR-LATEIALKTKGNLVDSMMRMMEEYANNLEKLVGERTKLAEEANLRAERL 813
Query: 889 LNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTF 948
L ++LP+ VA L G V P+ ++ ++ FSDIVGFT L + ST ++VV+LLN LY+ F
Sbjct: 814 LFQLLPKHVAIELKAGRTVAPKMYDSATVMFSDIVGFTKLCSASTPIEVVNLLNKLYSEF 873
Query: 949 DAAIEQYRVYKVETIGDAYMVVGGLP-QRTRDHAESVATMALHLLHLAGRFRVRHLPDTP 1007
D I ++ YKVETIGDAYMVV G+P + + H +++ + L ++ L F V H D
Sbjct: 874 DTVISKHDCYKVETIGDAYMVVSGIPIENGQRHVANISAVTLGIMDLLKVFEVPHRRDYR 933
Query: 1008 LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAG 1067
L +R+G +G A VVGL+ PRYCLFG+TVN A+ MES+G R+QI+ T+ K+L
Sbjct: 934 LTIRLGFASGQVSAAVVGLSSPRYCLFGETVNIAAVMESSGEGGRVQITETS--KILLEN 991
Query: 1068 GYK---LRSRGLTQIKGKGAMHTYWLLGKE 1094
Y + RG+ + + TYWL GK+
Sbjct: 992 EYPEFIIEIRGINKDVKQDDFVTYWLTGKD 1021
>UniRef50_Q23496 Cluster: Guanylate cyclase; n=2; Caenorhabditis|Rep:
Guanylate cyclase - Caenorhabditis elegans
Length = 1118
Score = 297 bits (728), Expect = 2e-78
Identities = 176/509 (34%), Positives = 285/509 (55%), Gaps = 41/509 (8%)
Query: 589 NRVVVDRRIRYKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRP 648
N ++ ++ G + ++ Q + + +L ++ +N+N F G +
Sbjct: 564 NGLIAAKQAVSNGVKLAIKRYQQVRNITFPKSELRLLKELKICENDNLNKFYGISFNQQN 623
Query: 649 ALV--FDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNC 706
+ + C RGSLED+L D++KL F++S D+VKG+ +LH SPL HG L +NC
Sbjct: 624 EFIVMWVLCSRGSLEDILFNDELKLGRNFQVSFAKDVVKGLNFLHTSPLLHHGMLCLQNC 683
Query: 707 VVDSRWVLRVTDYGLPA-----LHRTQGLP--------------PAQRTPRE-LLWTAPE 746
+VDS W +++T++ A L + P P + R+ L APE
Sbjct: 684 LVDSNWTVKLTNFATEAVIFEKLDHNELRPFINTDSESADDVSDPTKDFARKKYLQQAPE 743
Query: 747 LIREAREGGGWL-ATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRP---PPL 802
+IRE +QS D+++ +++ +++ R EP+ + + ++++ L L
Sbjct: 744 IIREIVTTKTIPEGSQSADIYALGMVLYQILFRVEPFHERNKSINKLMETLAMANDDDQL 803
Query: 803 IRPSVSMGAAPP----EAVSVMRQCWSEAPDLRPDFNRLHDVFR-QMQRGRKINIVDSMF 857
IRP+ + +S + CW E P++RP ++ + ++ K ++VD M
Sbjct: 804 IRPTFPSSNTGEGYNLQLLSCIEACWLEIPEMRPPIKKVRTMVNANLKSTGKGSLVDQMM 863
Query: 858 EMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSI 917
+M+E+Y+ NLE ++R+RT L+ +K+ ++LLN MLP+S+AE L +G V P+ + ++
Sbjct: 864 KMMEEYTANLENMVRDRTALLEEAQKQADRLLNSMLPKSIAEDLKIGKPVLPQLYSCATV 923
Query: 918 YFSDIVGFTALAARSTAVQV---------VDLLNDLYTTFDAAIEQYRVYKVETIGDAYM 968
FSDI GFT +++ ST +QV V LND+++ FDA I ++ YKVETIGDAYM
Sbjct: 924 LFSDIRGFTRISSTSTPLQVCKLRQKIIVVTFLNDMFSGFDAIIAKHDAYKVETIGDAYM 983
Query: 969 VVGGLP-QRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLT 1027
+V G+P + HA+++A +AL + F++ H P+ + +RIG H+GP AGVVGL
Sbjct: 984 IVSGVPTENGNSHAQNIADVALKMRAFICNFKLAHRPEELMMVRIGFHSGPVAAGVVGLA 1043
Query: 1028 MPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
PRYCLFGDTVNTASRMESTG A +IQIS
Sbjct: 1044 APRYCLFGDTVNTASRMESTGVANKIQIS 1072
>UniRef50_O77149 Cluster: NO-insensitive guanylyl cyclase; n=1;
Manduca sexta|Rep: NO-insensitive guanylyl cyclase -
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Length = 500
Score = 289 bits (710), Expect = 2e-76
Identities = 154/318 (48%), Positives = 205/318 (64%), Gaps = 4/318 (1%)
Query: 781 PYCMLS--FTPEEIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLH 838
P+C L+ + + DK R + S +A P W+ D RPDF+ L
Sbjct: 27 PHCTLACDYCAAILEDKFKRSAEMRNRGTSPLSASPRQSLTGEPPWTLPDDDRPDFSALK 86
Query: 839 DVFRQMQRGRKINI-VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSV 897
+ ++ + + + +D + +E+Y+NNLE L+ ERT EK+K E+LL ++LP+SV
Sbjct: 87 ENIHRINKDCETSTRLDMLLTQVEQYANNLEALVEERTSDYLEEKRKCEELLYQLLPKSV 146
Query: 898 AERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRV 957
A +L++G V E +++V+IYFSDI+GFT L+A ST ++VVDLLNDLYT+FD+ IE + V
Sbjct: 147 ASQLIMGQPVMAETYDQVTIYFSDIIGFTQLSAESTPLEVVDLLNDLYTSFDSIIENFDV 206
Query: 958 YKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT 1016
YKVETIGDAYMVV GLP R + HA +A M+L LL+ V H P L LRIG+HT
Sbjct: 207 YKVETIGDAYMVVSGLPMRNGNRHAAEIARMSLALLNAVRVKTVPHRPGERLLLRIGMHT 266
Query: 1017 GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGL 1076
GPC AGVVGL MPRYCLFGDTVNTASRMES G A +I +S T E L ++L RG
Sbjct: 267 GPCVAGVVGLKMPRYCLFGDTVNTASRMESHGEALKIHVSPKTKEVLDLYDCFELDCRGE 326
Query: 1077 TQIKGKGAMHTYWLLGKE 1094
+KGKG M TYWLLG++
Sbjct: 327 ITMKGKGKMTTYWLLGEK 344
>UniRef50_Q9U317 Cluster: Putative uncharacterized protein gcy-25;
n=2; Caenorhabditis|Rep: Putative uncharacterized protein
gcy-25 - Caenorhabditis elegans
Length = 1044
Score = 282 bits (691), Expect = 5e-74
Identities = 169/522 (32%), Positives = 279/522 (53%), Gaps = 41/522 (7%)
Query: 607 RHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVFDE-CWRGSLEDVL 664
RH+Q + R+ ++L ++ + N+NPF G C +G +V + R SLED++
Sbjct: 497 RHVQ-RRAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSELIVMWQFTTRYSLEDLI 555
Query: 665 MADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPAL 724
+ K F+ + + +V G+ Y+H S ++ HG L NCVVDS WV+++TD+G+ +
Sbjct: 556 FVKEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGI 615
Query: 725 --HRT--QGLPPAQRTPREL-----LWTAPE----LIREAREGGGWLATQSGDVFSFAII 771
RT + L P+ + L APE ++ + E G T GD++ A+
Sbjct: 616 LKERTNHKELAPSSAFDVDAIHYKYLQLAPEHISAILEKLEEPRG---TVEGDIYQLAMC 672
Query: 772 MQEVIVRGEPYC----MLSFTPEEIIDKLCRPPPLIRPSVSMGAAP-----PEA------ 816
+ +++ P+ + EI KL P L S AP PE
Sbjct: 673 IYQILFYMRPFAERQESIKVYSGEIFLKL---PELAHLLSSQSTAPLHPKVPEGNSFTMR 729
Query: 817 -VSVMRQCWSEAPDLRPDFNRLHD-VFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRER 874
+S+++QCW P RP ++ D V R+ + K ++D M EM+++YS NLE+++ ER
Sbjct: 730 LLSIIQQCWLYKPAARPALIKITDAVNREFGQDVKGTLIDQMIEMIDEYSANLEQIVAER 789
Query: 875 TEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTA 934
T +L+ + TE LL ++LP+SVA+ + G V PE+ V++ D+ FT
Sbjct: 790 TRELEQDMSVTENLLYQLLPKSVADSIRSGKTVVPEQHSSVTLLVVDVCQFTKFCEAFIP 849
Query: 935 VQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTR-DHAESVATMALHLLH 993
V +++ L +LY++FD +++ + +KVE +GDAY++ G+P+ + H + ++L L
Sbjct: 850 VHILETLQELYSSFDNIVQKNKAFKVENVGDAYLICSGIPEMSGFRHLREICKISLKLQA 909
Query: 994 LAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRI 1053
F+VRH P L +++G+ +G AG++G T PR+C+FGDTVN A RM STG I
Sbjct: 910 FMKTFKVRHRPSHTLQIKMGITSGAVAAGILGSTAPRFCIFGDTVNMACRMASTGNPGSI 969
Query: 1054 QISSTTAEKLLAA-GGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
Q+S TA L+ + L RG+ +KGKGA T+WL G++
Sbjct: 970 QLSELTANTLMEKFPSFMLEERGMIDVKGKGACLTFWLTGEK 1011
>UniRef50_Q5SR07 Cluster: Natriuretic peptide receptor A/guanylate
cyclase A; n=14; cellular organisms|Rep: Natriuretic
peptide receptor A/guanylate cyclase A - Homo sapiens
(Human)
Length = 255
Score = 278 bits (681), Expect = 8e-73
Identities = 143/234 (61%), Positives = 170/234 (72%), Gaps = 4/234 (1%)
Query: 860 LEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYF 919
+E+Y+NNLEEL+ ERT+ EK+K E LL ++LP SVAE+L G V+ E F+ V+IYF
Sbjct: 1 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 60
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT-R 978
SDIVGFTAL+A ST +QVV LLNDLYT FDA I+ + VYKVETIGDAYMVV GLP R R
Sbjct: 61 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGR 120
Query: 979 DHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTV 1038
HA VA MAL LL FR+RH P L LRIG+HTGP CAGVVGL MPRYCLFGDTV
Sbjct: 121 LHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTV 180
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKG---AMHTYW 1089
NTASRMES G A +I +SS T L GG++L RG ++K +G A+ T+W
Sbjct: 181 NTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKVEGEASALPTFW 234
>UniRef50_UPI0000F1EB17 Cluster: PREDICTED: similar to
ENSANGP00000011644; n=3; Euteleostomi|Rep: PREDICTED:
similar to ENSANGP00000011644 - Danio rerio
Length = 584
Score = 262 bits (642), Expect = 4e-68
Identities = 126/246 (51%), Positives = 170/246 (69%), Gaps = 1/246 (0%)
Query: 852 IVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE 911
IV F+ + ++ + + +RE+TE L E++ E LL++MLP+SVA++L E E
Sbjct: 262 IVLLSFKQMTEWIQDYAQSLREKTEDLKRERRLAEDLLHQMLPKSVAKQLRQNKHFEAES 321
Query: 912 FEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVG 971
+E+V+I+FSDIVGFTA++A T +QVV++LN+LY FD I+ Y VYKVETIGDAYMVV
Sbjct: 322 YEKVTIFFSDIVGFTAISASCTPLQVVEMLNNLYMCFDTRIDSYDVYKVETIGDAYMVVS 381
Query: 972 GLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPR 1030
GLP+R D HA+ +A M+L L+ + + H+P L LR G+HTGPC AGVVG MPR
Sbjct: 382 GLPERNGDRHADEIAKMSLDLVAAVRQVPIPHMPTKRLQLRAGIHTGPCVAGVVGYKMPR 441
Query: 1031 YCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
YCLFGDTVNTASRMEST +I SS T L+ Y+L+ RG ++KGKG M TYWL
Sbjct: 442 YCLFGDTVNTASRMESTSLPQKIHASSATYLALMKDNAYELQLRGEVEVKGKGKMDTYWL 501
Query: 1091 LGKEGF 1096
+G + +
Sbjct: 502 IGHKNY 507
>UniRef50_Q9NGZ8 Cluster: Guanylyl cyclase; n=4; Caenorhabditis|Rep:
Guanylyl cyclase - Caenorhabditis elegans
Length = 1017
Score = 261 bits (639), Expect = 1e-67
Identities = 155/482 (32%), Positives = 245/482 (50%), Gaps = 22/482 (4%)
Query: 623 DVLLLMQNLRQENVNPFIGCLCEG---RPALVFDECWRGSLEDVLMADDIKLDWTFRLSL 679
D L ++ L+ +N+ F G ++ RG+LE+ + D +D TF+ +
Sbjct: 518 DYLYSLKQLQHDNLAKFYGIQVNDDIMTMTILHTLVERGTLEEFCLDRDFGMDDTFKSAF 577
Query: 680 LSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRE 739
+ D++KG++YLH S + HG L + C++D WVL++T YG+ Q + P +
Sbjct: 578 MRDILKGLQYLHKSSIGYHGHLQASTCLIDINWVLKLTLYGVSNFMSDQLDAENIKVPEQ 637
Query: 740 L---------LWTAPELIREAREGGGW-----LATQSGDVFSFAIIMQEVIVRGEPYCML 785
+ PE IRE + G + GD++ +I ++ R +PY ++
Sbjct: 638 AAHMITYPQYVCFPPEHIREYDDSGKQPPRVVRGSPKGDIYCVGMIFYMMVEREDPYHLI 697
Query: 786 SFTPE---EIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFR 842
+I ++ + R + + + ++CW PD RP +L +
Sbjct: 698 HSVERPNASLIKQILNENHMPRITDDY-RQENMLLEMCKECWDRNPDKRPTIKKLIESIS 756
Query: 843 QMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLM 902
+ K N+VD M M EKY++ LE+++ RT L + +T +LLN MLP S+A+ L
Sbjct: 757 TVYPLSKGNLVDQMIRMSEKYADELEQMVAIRTADLADAQMQTMRLLNEMLPASIAKDLK 816
Query: 903 LGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVET 962
G + P +E ++ F I F AL RS+ QV+ LND+Y FD I+++ YKVET
Sbjct: 817 NGLIMPPRSYESATVMFVQICDFNALMKRSSPEQVIAFLNDIYDQFDTVIKRHDAYKVET 876
Query: 963 IGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCA 1021
G+ YMV G+P H VA ++L + ++ + ++H + L +RIG H GP A
Sbjct: 877 TGETYMVASGVPHENEGRHIFEVAEISLEIREISYIYVLQHDKNYKLRIRIGFHAGPIAA 936
Query: 1022 GVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKG 1081
GV+G+ PRYCLFGDTVN ASRM+S +IQ S TA L + YK RG+ +KG
Sbjct: 937 GVIGIRSPRYCLFGDTVNFASRMQSNCPPNQIQTSEITARLLFDSHEYKFVKRGIVHVKG 996
Query: 1082 KG 1083
KG
Sbjct: 997 KG 998
>UniRef50_UPI0000E47581 Cluster: PREDICTED: similar to natriuretic
peptide receptor A; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to natriuretic peptide
receptor A - Strongylocentrotus purpuratus
Length = 1008
Score = 260 bits (637), Expect = 2e-67
Identities = 128/245 (52%), Positives = 167/245 (68%), Gaps = 1/245 (0%)
Query: 851 NIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPE 910
+I+D++ +E+Y+ NLE L+ ERT EKK++E LL +LPRSVA++L G V P
Sbjct: 763 SILDNLLSRMEQYATNLEALVEERTAAFLEEKKRSETLLYEVLPRSVADQLKRGEAVNPT 822
Query: 911 EFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVV 970
++ +IYFSDIVGFT L+A ST +QVV LLNDLYT FD I Y VYK++T+ DAYMVV
Sbjct: 823 SYDSTTIYFSDIVGFTTLSADSTPMQVVTLLNDLYTCFDEIIGNYDVYKIKTVCDAYMVV 882
Query: 971 GGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMP 1029
GLP + HA ++ M+L L+ FR+ H P+ L LR+G+H+GPC AGVVGL MP
Sbjct: 883 SGLPIGNGNLHAREISAMSLALIKEVSTFRISHRPEEKLKLRVGIHSGPCVAGVVGLKMP 942
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYW 1089
RYCLFGDTVNTASRMESTG A +I +S T L ++ RG ++KGKG+ TYW
Sbjct: 943 RYCLFGDTVNTASRMESTGEAMKIHLSEKTKLILEEFQCFQTILRGRVELKGKGSYLTYW 1002
Query: 1090 LLGKE 1094
LL +
Sbjct: 1003 LLSMD 1007
Score = 124 bits (298), Expect = 2e-26
Identities = 66/162 (40%), Positives = 100/162 (61%), Gaps = 10/162 (6%)
Query: 626 LLMQNLRQENVNPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLV 684
L M+ + N+ F+G CL +V + C +GSL+D+L D +KLD F+ SL+ D++
Sbjct: 595 LQMRQVEHNNLARFVGACLDIPNVCVVIEYCPKGSLQDILGNDSLKLDAMFKDSLIIDII 654
Query: 685 KGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGL---PPAQRTPRELL 741
+G+ YLH S + HGRL+S NCVVDSR+VL++TD+GL ++ + A ++LL
Sbjct: 655 RGLHYLHNSVIGVHGRLTSSNCVVDSRFVLKLTDFGLRRFRKSDCITHDDDAMIERQKLL 714
Query: 742 WTAPELIRE-AREGGGWLATQSGDVFSFAIIMQEVIVRGEPY 782
W APE + + A E TQ GD++S II+QE++ R PY
Sbjct: 715 WKAPEGVNDPAAE-----PTQEGDIYSVGIILQEIVTRNPPY 751
>UniRef50_Q17BS6 Cluster: Guanylate cyclase; n=2; Culicidae|Rep:
Guanylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 574
Score = 249 bits (609), Expect = 4e-64
Identities = 124/226 (54%), Positives = 161/226 (71%), Gaps = 2/226 (0%)
Query: 868 EELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTA 927
+EL+ RT +L EK K+++LL +MLP +V +L +V E FE V+I+FSDIVGFT
Sbjct: 319 KELVT-RTLELRCEKSKSDRLLYQMLPPAVVRQLKQQRQVPAETFESVTIFFSDIVGFTY 377
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVAT 986
++A STA++VV +LN LY FD I +Y VYKVETIGDAYMVV GLPQR D HA +A
Sbjct: 378 ISAVSTAMEVVTMLNTLYRLFDTIILKYDVYKVETIGDAYMVVSGLPQRNGDKHAGEIAM 437
Query: 987 MALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMES 1046
M+L LL F + H+ + L +R+G++TGPC AGVVG TMPRYCLFGDT+NTASRMES
Sbjct: 438 MSLDLLCGISGFIIPHMKNRTLEIRVGVNTGPCVAGVVGTTMPRYCLFGDTINTASRMES 497
Query: 1047 TGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
TG +I +S T E L GG+K++ RG ++KGKG M T+WL+G
Sbjct: 498 TGEPMKIHLSENTKEILDKLGGFKIKRRGTIEVKGKGTMETFWLVG 543
>UniRef50_Q7YXG2 Cluster: Soluble guanylyl cyclase 1 beta; n=1; Limax
marginatus|Rep: Soluble guanylyl cyclase 1 beta - Limax
marginatus
Length = 444
Score = 237 bits (580), Expect = 1e-60
Identities = 118/235 (50%), Positives = 162/235 (68%), Gaps = 3/235 (1%)
Query: 858 EMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSI 917
++ ++ EL+R ++ L+ EK KTE LL++MLPR VA L G +VE E+F++V++
Sbjct: 2 DIAKRLDETTAELMRT-SQALEEEKSKTETLLHQMLPRKVATALTHGQKVEAEKFDQVTV 60
Query: 918 YFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT 977
FSDIV FT +A+ + + +V++LN++Y FD Q+ VYKVETIGDAYM+V G+P+RT
Sbjct: 61 LFSDIVTFTNIASACSPMDIVNMLNEMYQRFDERTSQHNVYKVETIGDAYMIVSGVPERT 120
Query: 978 RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDT 1037
+HA+ VA AL ++ AG R PL +R+G+HTGP AGVVG+ MPRYCLFGDT
Sbjct: 121 TNHAQPVADFALDMVEDAGLVR-SPATGLPLQIRVGVHTGPVVAGVVGVKMPRYCLFGDT 179
Query: 1038 VNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
VNTASRMES GA RI + S TA + L + GY + RG ++KGKG M TY+L G
Sbjct: 180 VNTASRMESHGAPGRIHM-SPTAYRALCSSGYVFKQRGQMEVKGKGVMSTYFLCG 233
>UniRef50_Q1EC29 Cluster: IP04501p; n=7; Endopterygota|Rep: IP04501p -
Drosophila melanogaster (Fruit fly)
Length = 710
Score = 236 bits (578), Expect = 2e-60
Identities = 122/247 (49%), Positives = 160/247 (64%), Gaps = 5/247 (2%)
Query: 850 INIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP 909
I +V + ++ Y+ NL + + ++L EK+K++ LL +MLP SVA +L +V
Sbjct: 432 IVLVKNAAATIQLYALNLSQ----KAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPA 487
Query: 910 EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMV 969
E +E V+IYFSDIVGFT +AA T ++VV LN +Y FD IE Y VYKVETIGD+YMV
Sbjct: 488 ELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMV 547
Query: 970 VGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTM 1028
GLP + + H +ATMAL LL + FR+ D + +R G+HTGP AG+VG M
Sbjct: 548 ASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKM 607
Query: 1029 PRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
PRYCLFGDTVNTASRMESTG A +I I+ + L GG++ RGL +KGKG M TY
Sbjct: 608 PRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTY 667
Query: 1089 WLLGKEG 1095
WL K+G
Sbjct: 668 WLTCKDG 674
>UniRef50_A7RZH8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 622
Score = 236 bits (578), Expect = 2e-60
Identities = 129/247 (52%), Positives = 161/247 (65%), Gaps = 7/247 (2%)
Query: 848 RKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRV 907
++I I+ S + S LEE +RE LD EK +T+ LL +M+P++VA+RL G
Sbjct: 381 KEIRIILSKDVKCMQKSAKLEESMRE----LDNEKLRTDALLYQMIPKTVADRLRKGEPA 436
Query: 908 --EPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGD 965
E F V+I FSD+VGFT + + +QVV +LN +YTTFD E++ VYKVETIGD
Sbjct: 437 LNTCETFSNVTILFSDVVGFTTICSLIAPMQVVTMLNCMYTTFDKLSEKHNVYKVETIGD 496
Query: 966 AYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVG 1025
AYMVV G+P+RT+ HAE VA MAL++L + L +RIG+HTG AGVVG
Sbjct: 497 AYMVVSGIPERTKYHAEHVADMALNMLSAMPEIEDPAGLNDHLRIRIGIHTGTVVAGVVG 556
Query: 1026 LTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAM 1085
L MPRYCLFGDTVNTASRMESTG A I +S T +K LA Y L+ RG IKGKG M
Sbjct: 557 LKMPRYCLFGDTVNTASRMESTGLAMAIHVSEDT-QKFLAKANYALKQRGSMDIKGKGGM 615
Query: 1086 HTYWLLG 1092
TYWLLG
Sbjct: 616 KTYWLLG 622
>UniRef50_Q8I4N4 Cluster: Putative uncharacterized protein daf-11;
n=2; Caenorhabditis|Rep: Putative uncharacterized protein
daf-11 - Caenorhabditis elegans
Length = 1093
Score = 234 bits (573), Expect = 1e-59
Identities = 166/521 (31%), Positives = 272/521 (52%), Gaps = 52/521 (9%)
Query: 616 ELKRKSTDVLLLMQ---NLRQENVNPFIGCLCE--GRPALVFDECWRGSLEDVLMADDIK 670
+L+ D+ LL Q +L+ +N+N F+G + +++++C+RGSL D + + +
Sbjct: 447 KLRYDKIDINLLYQMKSHLQHDNLNSFVGITIDKASHMYIIWNQCFRGSLHDHIFTKERQ 506
Query: 671 LDWTFRLS--LLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPAL---H 725
R L D++KG+ Y+H S + HG L+ NC++DS W+++++ +G+ L
Sbjct: 507 RGTATRFEGLFLRDILKGLEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKW 566
Query: 726 RTQG-LPPAQRTP----RELLWTAPELIR-----EAREGGGWLATQSG---DVFSFAIIM 772
+T G + TP EL + P + + R + Q G D++SF +I+
Sbjct: 567 KTSGQIFTEDHTPVIKSEELHYFDPAMKKIWKNYADRNERALITPQFGKKCDMYSFGVIL 626
Query: 773 QEVIVRGEPYCMLSFTPEEIIDKLCR-----------PPPLIRPS-VSMGAAPPEAVSVM 820
E+I++ + L +P E D + P P+I P + M + + ++
Sbjct: 627 HEIILKKKFVEQLFDSPREEDDSVLIDDENDAIASRFPLPIIIPEGIEMHN---DLIKML 683
Query: 821 RQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDM 880
C+ +RPD + + + ++VD M + L Y+ L E ++ RT +L+
Sbjct: 684 ENCFGS---VRPDIALARKIIDTVLK-MSGSLVDLMIKNLTAYTQGLNETVKNRTAELEK 739
Query: 881 EKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDL 940
E++K +QLL +LP+SVA L G V+P+ +E +I +SDIVGFT+L ++S ++VV L
Sbjct: 740 EQEKGDQLLMELLPKSVANDLKNGIAVDPKVYENATILYSDIVGFTSLCSQSQPMEVVTL 799
Query: 941 LNDLYTTFDAAIEQYRVYKV------ETIGDAYMVVGGLP-QRTRDHAESVATMALHLLH 993
L+ +Y FD I Q YKV ETIGDAY V GLP +DH +S+ +AL
Sbjct: 800 LSGMYQRFDLIISQQGGYKVILNRIMETIGDAYCVAAGLPVVMEKDHVKSICMIALLQRD 859
Query: 994 LAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRI 1053
F + H P T L+ R G ++GP AGV+G PRY FG+ V AS+MES+G RI
Sbjct: 860 CLHHFEIPHRPGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSGVEDRI 919
Query: 1054 QISSTTAEKLLAAG--GYKLRSRGLTQIKGKGAMHTYWLLG 1092
Q+ + +++LL + +RG I+G G + TYWL G
Sbjct: 920 QM-TLASQQLLEENFPQFVCSNRGGRTIEGIGRILTYWLEG 959
>UniRef50_UPI0000586706 Cluster: PREDICTED: similar to guanylate
cyclase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to guanylate cyclase -
Strongylocentrotus purpuratus
Length = 650
Score = 234 bits (572), Expect = 1e-59
Identities = 121/243 (49%), Positives = 152/243 (62%), Gaps = 1/243 (0%)
Query: 852 IVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE 911
I+ E L N + ++T+ L E+K+T+ LL +MLP SVAE L V E
Sbjct: 379 IIIKAVESLTSNMQNYVLTLADQTKALHKERKRTDTLLYQMLPISVAENLKRNQVVHAEN 438
Query: 912 FEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVG 971
F +I FSDIVGFT + + S+ +QVVD+LN++YT FD+ I+ Y VYKVETIGDAYMVV
Sbjct: 439 FTAATILFSDIVGFTRICSESSPLQVVDMLNNVYTKFDSRIDTYNVYKVETIGDAYMVVS 498
Query: 972 GLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPR 1030
G+PQR HA +A MAL LL+ + H P T + LRIG+HTGP AG+VG MPR
Sbjct: 499 GVPQRNGNKHASEIALMALDLLNCIKGLVIPHRPGTKMTLRIGIHTGPVVAGIVGSKMPR 558
Query: 1031 YCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
YCLFG+TVN AS+MES G RIQIS L GGY + RG + KG M TYWL
Sbjct: 559 YCLFGETVNIASKMESNGLPNRIQISDDCHRILKITGGYTMVRRGEVLLTDKGTMTTYWL 618
Query: 1091 LGK 1093
G+
Sbjct: 619 TGR 621
>UniRef50_A7RU15 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 346
Score = 231 bits (566), Expect = 7e-59
Identities = 117/271 (43%), Positives = 172/271 (63%), Gaps = 13/271 (4%)
Query: 662 DVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGL 721
DVL D +KLDW F++S SD+ +GM YLH SP+ HG L S NCV+DSRWV +++D+GL
Sbjct: 80 DVLNNDSLKLDWMFQISFASDIARGMLYLHKSPISVHGNLKSSNCVIDSRWVCKISDFGL 139
Query: 722 PALHRTQGLPPAQR----TPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIV 777
Q P + +LLW APE + + G +Q GDVFS+ II+QE+++
Sbjct: 140 RKFKDGQA-PDMELGFDFLYNQLLWCAPENLTDPERPG---KSQPGDVFSYGIILQEILL 195
Query: 778 RGEPYCMLSFTPEEIIDKLCRPP--PLIRPSVSMGAAPPEAVS---VMRQCWSEAPDLRP 832
RG PYC F + I R P RP+V + P ++ +M++CW E+P LRP
Sbjct: 196 RGLPYCTEQFMEAKAIVSRVRQGEVPPFRPNVYAETSNPSNIAYIHLMQECWEESPALRP 255
Query: 833 DFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRM 892
+F + +++ +GR +NI+D+M M+E+Y+++LE+L+RERT QL+ EK +T+ LL RM
Sbjct: 256 NFFSILRRLKKINKGRDVNIMDNMIAMMERYTDHLEDLVRERTHQLEEEKLRTDALLYRM 315
Query: 893 LPRSVAERLMLGSRVEPEEFEEVSIYFSDIV 923
LPR+VAE+L G + E F+ V+I+FSDIV
Sbjct: 316 LPRTVAEQLKQGQPITAESFDSVTIFFSDIV 346
>UniRef50_UPI0000586B0F Cluster: PREDICTED: similar to receptor type
guanylyl cyclase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to receptor type guanylyl cyclase -
Strongylocentrotus purpuratus
Length = 688
Score = 230 bits (562), Expect = 2e-58
Identities = 109/180 (60%), Positives = 138/180 (76%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAA 930
+ E+T +LD E+K+ ++LL +MLPR VA++L +G V E++E V+IYFSDIVGFT+LAA
Sbjct: 391 LSEKTRELDAERKRADRLLYQMLPRCVADQLKMGLSVAAEQYEHVTIYFSDIVGFTSLAA 450
Query: 931 RSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALH 990
+ +QVV++LN LY+ FD I++Y VYKVETIGDAYMVV GLP T HA ++TMAL
Sbjct: 451 ACSPLQVVNMLNGLYSMFDGCIDKYNVYKVETIGDAYMVVSGLPDATDRHAWEISTMALE 510
Query: 991 LLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
L L F+V H+ D L LRIG+H+G C AGVVGL MPRYCLFGDTVNTASRMES+G A
Sbjct: 511 LRSLVMGFKVPHMNDATLRLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNTASRMESSGEA 570
>UniRef50_Q7YXG1 Cluster: Soluble guanylyl cyclase 2 beta; n=1; Limax
marginatus|Rep: Soluble guanylyl cyclase 2 beta - Limax
marginatus
Length = 406
Score = 229 bits (560), Expect = 4e-58
Identities = 119/237 (50%), Positives = 159/237 (67%), Gaps = 3/237 (1%)
Query: 858 EMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSI 917
++ +K EL R E L+MEK+KTE+LL +MLP VA +L G VE E+F++V++
Sbjct: 5 DITKKLDETTAELKRTSRE-LEMEKQKTERLLYQMLPEKVANQLKNGQAVEAEKFDQVTV 63
Query: 918 YFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT 977
FSDIV FT +A+ + + +V +LND+Y FD ++ VYKVETIGDAYMVV G+P++T
Sbjct: 64 LFSDIVTFTDIASACSPMDIVKMLNDMYNRFDKKTNEHGVYKVETIGDAYMVVCGVPEKT 123
Query: 978 RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDT 1037
HA+ VA+ AL ++ A + PL +R+G+HTGP AGVVG+ MPRYCLFGDT
Sbjct: 124 DTHAQPVASFALDMVEQAACV-MSPATGKPLQIRVGIHTGPVVAGVVGVRMPRYCLFGDT 182
Query: 1038 VNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
VNTASRMES G RI +S +T + L GY + RG T IKGKG M TY+LLG +
Sbjct: 183 VNTASRMESHGMPGRIHLSPSTFQ-ALEGQGYTCKCRGETLIKGKGCMVTYFLLGDQ 238
>UniRef50_UPI0000E49095 Cluster: PREDICTED: similar to guanylate
cyclase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to guanylate cyclase -
Strongylocentrotus purpuratus
Length = 699
Score = 229 bits (559), Expect = 5e-58
Identities = 114/225 (50%), Positives = 150/225 (66%), Gaps = 1/225 (0%)
Query: 874 RTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARST 933
+T+ L+ EKK+ LL MLP +VA +LM G V+ E ++ +++F+DI GF+ L A S+
Sbjct: 424 QTKALNTEKKRANWLLCSMLPETVANQLMHGYNVQAEWYDSATVFFADIFGFSRLCAESS 483
Query: 934 AVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLL 992
+QVV++LN LY FD+ IE Y VYKVETI + YM+ GLP R D HA VAT+AL L
Sbjct: 484 PMQVVEMLNGLYLVFDSRIEHYDVYKVETINETYMLASGLPVRKGDQHAGEVATIALDLQ 543
Query: 993 HLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWR 1052
+ V H + L +R+G+H+GP A VVGL MPRYCLFGDTVN ASRM++TG R
Sbjct: 544 YHVSFLEVPHKRNEKLTIRVGIHSGPVVAAVVGLKMPRYCLFGDTVNIASRMQTTGVPGR 603
Query: 1053 IQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEGFD 1097
+QIS T L GGYK+ RG +IKGKG + TYWL GK+ F+
Sbjct: 604 VQISYETFAALNDLGGYKVVKRGEIEIKGKGLLTTYWLNGKDNFE 648
>UniRef50_UPI0000E48651 Cluster: PREDICTED: similar to membrane
guanylyl cyclase, partial; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to membrane guanylyl
cyclase, partial - Strongylocentrotus purpuratus
Length = 558
Score = 228 bits (557), Expect = 8e-58
Identities = 130/372 (34%), Positives = 212/372 (56%), Gaps = 24/372 (6%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVFDECWR 657
Y G V ++ + + L ++ + +++L+ N+ F G C+ +++ + C +
Sbjct: 200 YNGQTVAVKMI-AKNSFTLDKRIRKEVKQVRDLQHSNLCKFAGGCIEVPNVSIITEYCPK 258
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
G+L DVL+ +D+ L+W+FR S D+ +GM Y+H + L HG+L+S NCVVD RWV+++
Sbjct: 259 GALSDVLLNEDVPLNWSFRFSFCMDVARGMHYMHNNKLY-HGKLTSSNCVVDDRWVVKIA 317
Query: 718 DYGLPALHRTQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIV 777
DYGL +G R L E R L TQ+ DV+S+ +I+ E+
Sbjct: 318 DYGLTTFRNQEGSQSNAGGYRSKAMQV-YLPPENRSNTYTLVTQATDVYSYGVILVEIAS 376
Query: 778 RGEPYCMLSFTPEEI--IDKLCRPPPLIRPSVSMG--------AAPPEAVSVMRQCWSEA 827
R E PE+ +D+ RPP P + +G P + +S++ +CW+
Sbjct: 377 RNE------VIPEDDYPLDEAWRPP---LPDLEIGDTTDDERCPCPADYLSLIERCWNIN 427
Query: 828 PDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQ 887
P RP F+++ + K++ VD M +++EKYS +LE ++ ERT+ L +EK+KT++
Sbjct: 428 PAQRPHFSQIRQTLHSINPS-KLSPVDLMMQLMEKYSRHLESIVAERTQDLLLEKQKTDR 486
Query: 888 LLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTT 947
LL MLP+ VA+ L G+ + E++E SI+FSDIVGFT+L++ S+ +VV LLN LY T
Sbjct: 487 LLYSMLPQPVADDLRQGNIAKAEQYESCSIFFSDIVGFTSLSSTSSPYEVVALLNKLYVT 546
Query: 948 FDAAIEQYRVYK 959
FD+ I+ Y VYK
Sbjct: 547 FDSIIDNYDVYK 558
>UniRef50_UPI0000E4A009 Cluster: PREDICTED: similar to soluble
guanylyl cyclase beta-3; n=4; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to soluble guanylyl
cyclase beta-3 - Strongylocentrotus purpuratus
Length = 818
Score = 221 bits (540), Expect = 1e-55
Identities = 116/226 (51%), Positives = 144/226 (63%), Gaps = 3/226 (1%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP--EEFEEVSIYFSDIVGFTAL 928
+ E +LD+E K+T+ LL +M+PR VAE+L G E F V+I FSD+VGFT +
Sbjct: 379 LEESMTKLDLEMKRTDSLLYQMIPRQVAEKLRRGEPATSTCEVFTAVTILFSDVVGFTTI 438
Query: 929 AARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMA 988
+R + VV LLN +Y FD E Y VYKVETIGDAYMVV G P T+ HA +A M+
Sbjct: 439 CSRIPPMAVVSLLNGMYIKFDNLSETYEVYKVETIGDAYMVVSGAPTTTKYHAVRIAEMS 498
Query: 989 LHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
L + D + +R+G+HTG AGVVGL MPRYCLFGDTVNTASRMESTG
Sbjct: 499 LAMRESMNDLIDPSSKDEIVKIRVGIHTGMVVAGVVGLKMPRYCLFGDTVNTASRMESTG 558
Query: 1049 AAWRIQISSTTAEKL-LAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
A +I +S TT +KL G Y + RG T +KGKG+M TYWL GK
Sbjct: 559 EALKIHMSETTKKKLDQWEGYYDIEERGSTNVKGKGSMKTYWLHGK 604
>UniRef50_UPI00006975C6 Cluster: Guanylyl CYclase family member
(gcy-27); n=1; Caenorhabditis elegans|Rep: Guanylyl
CYclase family member (gcy-27) - Caenorhabditis elegans
Length = 712
Score = 219 bits (536), Expect = 3e-55
Identities = 146/497 (29%), Positives = 234/497 (47%), Gaps = 45/497 (9%)
Query: 615 LELKRKSTDVLLLMQNLRQENVNPFIGCLCE---GRPALVFDECWRGSLEDVLMADDIKL 671
+++ S D L ++ L+ +N+ F G ++ RG+LE+ + D +
Sbjct: 218 IDITNASLDFLYNLKQLKHDNLANFYGIQLNDDLNTMTILHALVERGTLEEFCLDRDFGM 277
Query: 672 DWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPAL----HRT 727
D TF+ + + D++KG++YLH SP+ HG L + C++D WVL++ YG+
Sbjct: 278 DETFKSAFMRDILKGLQYLHLSPVAYHGHLHAATCLIDINWVLKIALYGVTNFVCDNFDA 337
Query: 728 QGLPPAQRTPRELLWTA-----PELIREAREGGGWLATQ------SGDVFSFAIIMQEVI 776
+ + R+ + + PE IRE + G L T+ GD++ +I +I
Sbjct: 338 ENITMPDRSDYTISYAQYVCFPPEHIREY-DATGKLPTRFVRGSKQGDIYCVGMIFYMMI 396
Query: 777 VRGEPYCMLSFTPEEIIDKLCRP-PPLIRPSVSMGAAPPEAV-SVMRQCWSEAPDLRPDF 834
R +PY ++ + + P +S + + ++CW+ P+ RP
Sbjct: 397 EREDPYRLIHSVERPGSGLMMEILDHNLMPFISNNETQEDTLLDKCKECWNRDPEKRPTI 456
Query: 835 NRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLP 894
L + K N++D M M EKY++ LE L+ R+ L + + +T +LLN MLP
Sbjct: 457 ENLRNAIAICYADSKGNLIDQMIRMNEKYADELETLVAARSADLALAQMQTMRLLNEMLP 516
Query: 895 RSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQ 954
S+A+ L G + ++ F I F + R +V
Sbjct: 517 ASIAKDLKNGVIAPARSYASATVMFVQICDFIVILKRRPPKEV----------------- 559
Query: 955 YRVYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIG 1013
ET G+ YMV G+P H VA M+L + ++ + + + + L +RIG
Sbjct: 560 ------ETTGETYMVASGVPNENEGRHVFEVAEMSLEIRAISLSYTLENDKNYKLRVRIG 613
Query: 1014 LHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRS 1073
H GP AGV+G+ PRYCLFGDTVN ASRM+S +IQ S TA LLA YKL
Sbjct: 614 FHAGPIAAGVIGIKNPRYCLFGDTVNFASRMQSNCPPLQIQTSEITARMLLATHEYKLVK 673
Query: 1074 RGLTQIKGKGAMHTYWL 1090
RG+ +KGKG ++ YWL
Sbjct: 674 RGIVHVKGKGEVNCYWL 690
>UniRef50_A6NJF2 Cluster: Uncharacterized protein NPR2; n=19;
Euteleostomi|Rep: Uncharacterized protein NPR2 - Homo
sapiens (Human)
Length = 265
Score = 217 bits (530), Expect = 2e-54
Identities = 118/280 (42%), Positives = 171/280 (61%), Gaps = 23/280 (8%)
Query: 687 MRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTAPE 746
M +LH S + +HG L S NCVVDSR+VL++TDYGL + T A+ L+ +
Sbjct: 1 MAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRST-----AEPDDSHALYAS-- 53
Query: 747 LIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCM--LSFTPEEIIDKLCRPP-PLI 803
Q DV+SF II+QE+ +R P+ + L +P+EI+ K+ P
Sbjct: 54 -------------MQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYF 100
Query: 804 RPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKY 863
RPS+ E V +M +CW++ P RPDF ++ R+ + +I+D++ +E+Y
Sbjct: 101 RPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQY 160
Query: 864 SNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIV 923
+NNLE+L+ ERT+ EK+K E LL ++LP SVAE+L G V+ E F+ V+IYFSDIV
Sbjct: 161 ANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIV 220
Query: 924 GFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETI 963
GFTAL+A ST +QVV LLNDLYT FDA I+ + VYK +++
Sbjct: 221 GFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKGQSV 260
>UniRef50_UPI0000ECB130 Cluster: Guanylate cyclase soluble subunit
beta-2 (EC 4.6.1.2) (GCS-beta-2).; n=2; Gallus
gallus|Rep: Guanylate cyclase soluble subunit beta-2 (EC
4.6.1.2) (GCS-beta-2). - Gallus gallus
Length = 659
Score = 216 bits (528), Expect = 3e-54
Identities = 117/254 (46%), Positives = 160/254 (62%), Gaps = 5/254 (1%)
Query: 838 HDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSV 897
HDV R + + + + E+ + EEL R ++ L+ EKKKTE LL MLP+ V
Sbjct: 397 HDVTRDLILLNQQRLAE--MELSNQLERKKEEL-RVLSKHLEEEKKKTEALLYAMLPQHV 453
Query: 898 AERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRV 957
A +L G RVE EF+E +I FSD+V FT + A+ +Q+V +LN +Y FD + V
Sbjct: 454 ANQLKEGKRVEAGEFKECTILFSDVVTFTNICAQCEPIQIVLMLNSMYLQFDRLTTVHDV 513
Query: 958 YKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTG 1017
YKVETIGDAYMVVGG+P HAE +A AL ++ +A + + P+ +R+G+HTG
Sbjct: 514 YKVETIGDAYMVVGGVPVPVSTHAERIANFALGII-IAAKGVQNPVSGNPIQIRVGIHTG 572
Query: 1018 PCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLT 1077
P AGVVG MPRYCLFGDTVN ASRMES G +I +SS +A + L +++ RG
Sbjct: 573 PVLAGVVGEKMPRYCLFGDTVNIASRMESHGVPSKIHLSS-SAYQCLKYKNFEMTERGEI 631
Query: 1078 QIKGKGAMHTYWLL 1091
++KGKG MHTY+L+
Sbjct: 632 EVKGKGKMHTYFLV 645
>UniRef50_Q8INF0 Cluster: Soluble guanylate cyclase 88E; n=12;
Coelomata|Rep: Soluble guanylate cyclase 88E - Drosophila
melanogaster (Fruit fly)
Length = 947
Score = 211 bits (515), Expect = 1e-52
Identities = 122/264 (46%), Positives = 165/264 (62%), Gaps = 15/264 (5%)
Query: 837 LHDVFRQ-MQRGRKINI-VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLP 894
+HD R M G + ++ + + ++ S LEE +R LD E ++T++LL +M+P
Sbjct: 342 MHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMR----LLDEEMRRTDELLYQMIP 397
Query: 895 RSVAERLMLGSR-VEP-EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAI 952
+ VA+RL G ++ E F+ VSI FSDIV FT + +R T ++VV +LN +Y+ FD
Sbjct: 398 KQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLT 457
Query: 953 EQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRI 1012
E+ VYKVETIGDAYMVV G P + +HAE V MAL ++ + P T HLRI
Sbjct: 458 ERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKD---PSTGQHLRI 514
Query: 1013 --GLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYK 1070
G+H+G AG+VGL MPRYCLFGDTVNTASRMEST A ++ IS +T K+L YK
Sbjct: 515 RVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST--KVLIGPNYK 572
Query: 1071 LRSRGLTQIKGKGAMHTYWLLGKE 1094
+ RG +KGKG M TYWL +E
Sbjct: 573 IIERGEIDVKGKGTMGTYWLEERE 596
>UniRef50_Q16JH8 Cluster: Soluble guanylate cyclase gcy; n=2;
Culicidae|Rep: Soluble guanylate cyclase gcy - Aedes
aegypti (Yellowfever mosquito)
Length = 1025
Score = 209 bits (511), Expect = 3e-52
Identities = 120/264 (45%), Positives = 164/264 (62%), Gaps = 15/264 (5%)
Query: 837 LHDVFRQ-MQRGRKINI-VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLP 894
+HD R M G + ++ + + ++ S LEE +R+ LD E ++T++LL +M+P
Sbjct: 345 MHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRK----LDEEMRRTDELLYQMIP 400
Query: 895 RSVAERLMLGSR-VEP-EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAI 952
+ VA+RL G ++ E F VSI FSD+V FT + +R T ++VV +LN +Y+ FD
Sbjct: 401 KQVADRLRRGENPIDTCEMFNSVSILFSDVVTFTEICSRITPMEVVSMLNAMYSIFDTLT 460
Query: 953 EQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRI 1012
E+ VYKVETIGDAYMVV G P++ ++HAE V MAL ++ + P T HLRI
Sbjct: 461 ERNNVYKVETIGDAYMVVSGAPEKEQNHAEKVCDMALDMIEAITDLKD---PSTGSHLRI 517
Query: 1013 --GLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYK 1070
G+H+G AG+VGL MPRYCLFGD+VNTASRMEST A +I IS +T L Y
Sbjct: 518 RVGVHSGAVVAGIVGLKMPRYCLFGDSVNTASRMESTSQAMKIHISQSTRNFL--PSNYH 575
Query: 1071 LRSRGLTQIKGKGAMHTYWLLGKE 1094
+ RG +KGKG M TYWL KE
Sbjct: 576 VSERGEIDVKGKGTMKTYWLDHKE 599
>UniRef50_O02298 Cluster: Soluble guanylate cyclase gcy-35; n=2;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-35 -
Caenorhabditis elegans
Length = 688
Score = 206 bits (503), Expect = 3e-51
Identities = 99/221 (44%), Positives = 147/221 (66%), Gaps = 2/221 (0%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAA 930
+++ ++L++EK+KT++LL ++P SVA+ L G ++ +EF + ++ F+DIV FT + A
Sbjct: 379 LKKMAQELEIEKQKTDELLCELMPASVADSLRSGKAMDAKEFADCTLLFTDIVTFTNICA 438
Query: 931 RSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALH 990
T VV LLNDLY FD + + YKVETIGDAYM+VGG+P+R +HAE V +++
Sbjct: 439 MCTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPERCENHAERVLNISIG 498
Query: 991 LLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
+L + + + + P+ +R+G+H GP AGVVG+ MPRYCLFGDTVN A++MES G
Sbjct: 499 ML-MESKLVLSPITHKPIKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGIQ 557
Query: 1051 WRIQISST-TAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
+I +S T L A Y RG T+I+GKG M+TY+L
Sbjct: 558 CKIHVSETGKLNGLKANPSYVFIDRGNTEIRGKGMMYTYFL 598
>UniRef50_O75343 Cluster: Guanylate cyclase soluble subunit beta-2;
n=32; Euteleostomi|Rep: Guanylate cyclase soluble subunit
beta-2 - Homo sapiens (Human)
Length = 617
Score = 205 bits (501), Expect = 5e-51
Identities = 109/231 (47%), Positives = 149/231 (64%), Gaps = 5/231 (2%)
Query: 864 SNNLE---ELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFS 920
SN LE E ++ ++ L +EKKKTE LL MLP+ VA +L G +V EF+ +I FS
Sbjct: 336 SNQLERKKEELQVLSKHLAIEKKKTETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFS 395
Query: 921 DIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDH 980
D+V FT + +Q+V++LN +Y+ FD + VYKVETIGDAYMVVGG+P +H
Sbjct: 396 DVVTFTNICTACEPIQIVNVLNSMYSKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNH 455
Query: 981 AESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNT 1040
A+ VA AL + ++ + + P+ LR+G+HTGP A VVG MPRYCLFGDTVNT
Sbjct: 456 AQRVANFALG-MRISAKEVTNPVTGEPIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNT 514
Query: 1041 ASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLL 1091
ASRMES G ++ + S TA + L G+K+ RG ++KGKG M TY+L+
Sbjct: 515 ASRMESHGLPNKVHL-SPTAYRALKNQGFKIIERGEIEVKGKGRMTTYFLI 564
>UniRef50_Q9EXQ2 Cluster: Adenylate cyclase; n=3; Oscillatoriales|Rep:
Adenylate cyclase - Spirulina platensis
Length = 671
Score = 204 bits (499), Expect = 9e-51
Identities = 107/245 (43%), Positives = 159/245 (64%), Gaps = 4/245 (1%)
Query: 851 NIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPE 910
N+ DS F LEK + LE+ + ERT L EK+++E+LL +LP+ +A++L +
Sbjct: 424 NLRDS-FIALEKTNRELEQRVLERTAALFQEKERSEELLLNVLPKPIADQLKANKKAIAS 482
Query: 911 EFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVV 970
EEV+I F+DIVGFT L+AR +++V LLN++++ FD +++++ K++TIGDAYMVV
Sbjct: 483 AIEEVTILFADIVGFTPLSARMDPIELVSLLNEMFSIFDNLADKHKLEKIKTIGDAYMVV 542
Query: 971 GGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDT-PLHLRIGLHTGPCCAGVVGLTMP 1029
GGLP +HAE++A MAL + +F+ +L + +RIG++TG AGV+G+
Sbjct: 543 GGLPLPQNNHAEAIADMALEMQAAMKQFQGSYLMGSESFQIRIGINTGAVVAGVIGIKKF 602
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYW 1089
Y L+GD VN ASRMES+G IQ++ T +L Y + RGL +KGKG M TYW
Sbjct: 603 IYDLWGDAVNIASRMESSGTPGSIQVTEETYHRL--KYNYIFKKRGLIPVKGKGQMTTYW 660
Query: 1090 LLGKE 1094
LLGK+
Sbjct: 661 LLGKK 665
>UniRef50_A7RY93 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 390
Score = 197 bits (481), Expect = 1e-48
Identities = 106/242 (43%), Positives = 150/242 (61%), Gaps = 10/242 (4%)
Query: 785 LSFTPEEIIDKL--CRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFR 842
+ + P EII K+ C PP RP + + ++R CW+E P+ RP F R+ + +
Sbjct: 130 IPYIPTEIIQKVLACSDPPF-RPQLQNDDGRANLLMLIRDCWAEDPEERPHFFRIVETQK 188
Query: 843 QMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRML------PRS 896
+ +K N++++M M+EK++N+L L+ ERT QL+ EK+KT++LL R+ P
Sbjct: 189 DRRAQQKPNVIENMVSMMEKHANHLAGLVDERTRQLNEEKEKTDRLLYRLHHPPPPPPPP 248
Query: 897 VAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYR 956
+AE+L + V+ EE+EEV+I+FSDIVGFT L + S +QVV+ LN LY FD I Q+
Sbjct: 249 IAEQLKAYNYVQAEEYEEVTIFFSDIVGFTKLCSNSKPLQVVEFLNILYVAFDEIITQFN 308
Query: 957 VYKVETIGDAYMVVGGLP-QRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLH 1015
VYKVETIGDAYMVV G P HA +A+MAL LL F + H P L LRIG++
Sbjct: 309 VYKVETIGDAYMVVSGCPVLNGNQHAAEIASMALELLSHMTVFHIPHQPHDQLQLRIGIN 368
Query: 1016 TG 1017
TG
Sbjct: 369 TG 370
Score = 61.3 bits (142), Expect = 2e-07
Identities = 29/84 (34%), Positives = 51/84 (60%), Gaps = 1/84 (1%)
Query: 615 LELKRKSTDVLLLMQNLRQENVNPFIGCLCEGRPALVFDECWRGSLEDVLMADDIKLDWT 674
+ L R+ L ++++ EN+N FIG E LV+ C +GSL+DVL+ ++ +D
Sbjct: 38 VHLSRRVLIELKQVRDISHENLNEFIGACIEPANILVWSHCRKGSLQDVLV-NEYLIDEA 96
Query: 675 FRLSLLSDLVKGMRYLHGSPLRAH 698
F++S++ D+ GM+YLH +R +
Sbjct: 97 FKISMVMDIASGMKYLHSMEVRTY 120
>UniRef50_Q4T7S3 Cluster: Guanylate cyclase; n=1; Tetraodon
nigroviridis|Rep: Guanylate cyclase - Tetraodon
nigroviridis (Green puffer)
Length = 549
Score = 195 bits (475), Expect = 7e-48
Identities = 99/162 (61%), Positives = 115/162 (70%), Gaps = 1/162 (0%)
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD 979
SDIVGFT L++ ST QVVD LN LYTTFD I+ Y VYKVETIGDAYMVV G+P+
Sbjct: 349 SDIVGFTHLSSCSTPYQVVDFLNKLYTTFDDIIDNYDVYKVETIGDAYMVVSGVPRENGI 408
Query: 980 -HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTV 1038
HA VA+MAL L+ + FR+ H P+T L +R G+H+GP AGVVG MPRYCLFGDTV
Sbjct: 409 LHASEVASMALDLVGVCRTFRIPHKPNTQLQIRAGIHSGPVVAGVVGTKMPRYCLFGDTV 468
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIK 1080
NTASRMEST A +IQ SS+T L GGY L RG Q+K
Sbjct: 469 NTASRMESTSLALKIQCSSSTFYLLQEIGGYSLECRGTLQVK 510
Score = 183 bits (445), Expect = 3e-44
Identities = 114/324 (35%), Positives = 175/324 (54%), Gaps = 17/324 (5%)
Query: 601 GDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVFDECWRGS 659
G V ++ +Q T L + + ++ L N+ FIG C+ A+V + C +GS
Sbjct: 1 GRTVAIKKIQAK-TFSLSKTIRQEVKQVRELDHPNLCKFIGGCVEVPNVAIVTEYCPKGS 59
Query: 660 LEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDY 719
L DVL+ ++I L+W FR S +D+ +GM YLH + HGRL S NCVVD RWV ++TDY
Sbjct: 60 LNDVLLNEEIPLNWGFRFSFATDIARGMSYLHQHRI-CHGRLKSPNCVVDDRWVCKITDY 118
Query: 720 GLPALHR---TQGLPPAQRTPRELLWTAPELIREAREGGGWLATQSGDVFSFAIIMQEVI 776
GL R T+ L Q+ E+ + APEL E T +GDVFS++II+ E+
Sbjct: 119 GLKTYRRDDETKTLSTYQQRLVEV-YLAPELTDSGVE-----PTLAGDVFSYSIILLEIA 172
Query: 777 VRGEPYCMLSFTPEEIIDKLCRP-PPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFN 835
R EP + + C P P LI P + ++R+C + P RP F+
Sbjct: 173 TRSEP---VPADESSVESAWCPPLPELISSKADTCPCPADYAELIRRCRAPNPAHRPAFD 229
Query: 836 RLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPR 895
++ F Q K++ VD M ++EKYS +LE L+ ERT+ L EK++T++LL MLP+
Sbjct: 230 QIKK-FVQRINPVKVSPVDMMMSLMEKYSKHLEVLVAERTQDLTHEKQRTDRLLYSMLPK 288
Query: 896 SVAERLMLGSRVEPEEFEEVSIYF 919
VA+ L G ++ + + +++F
Sbjct: 289 QVADDLRQGKPLQAQSYVSATVFF 312
>UniRef50_Q5YLC2 Cluster: Soluble guanylyl cyclase beta; n=1;
Chlamydomonas reinhardtii|Rep: Soluble guanylyl cyclase
beta - Chlamydomonas reinhardtii
Length = 991
Score = 193 bits (471), Expect = 2e-47
Identities = 104/214 (48%), Positives = 139/214 (64%), Gaps = 3/214 (1%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQV 937
LD E+++++ LL +MLP VA L R +E E ++ FSDIVGFT +A+RS+ ++V
Sbjct: 439 LDEERRRSDGLLYQMLPPEVASCLKNEERAPAQEHPEATVLFSDIVGFTEIASRSSPLEV 498
Query: 938 VDLLNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAG 996
LL++LY FDAAIE+Y ++YKVETIGDAYMVV + DHA+ + AL + A
Sbjct: 499 CSLLDELYQRFDAAIEEYPQLYKVETIGDAYMVVCNVTVPCDDHADVLLEFALRMHEEAS 558
Query: 997 RFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
R V P+ +R+G+H+GP AGVVG MPR+CLFGDTVNTASRMES G A +I IS
Sbjct: 559 R--VASSLGEPVRIRVGMHSGPVVAGVVGRKMPRFCLFGDTVNTASRMESHGEAGQIHIS 616
Query: 1057 STTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
L + +++R RG +KGKG M TY L
Sbjct: 617 EACYCCLRSKERFEIRERGNITVKGKGTMRTYLL 650
>UniRef50_A0YIQ8 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 358
Score = 193 bits (470), Expect = 3e-47
Identities = 101/244 (41%), Positives = 157/244 (64%), Gaps = 5/244 (2%)
Query: 851 NIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPE 910
+++ + +M + + E ++ + L +EK+K+EQLL +LP+++AE+L + +
Sbjct: 110 DVISAFIQMFTQIHQAITER-QQAEDALRVEKEKSEQLLLNILPQAIAEQLKKQPGLIAD 168
Query: 911 EFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVV 970
FE+ +I F+DI FT LA++ + ++V LLN ++++FD E++ + K++TIGDAYMVV
Sbjct: 169 RFEQATILFADITDFTGLASQISPTELVSLLNQIFSSFDRLAERHGLEKIKTIGDAYMVV 228
Query: 971 GGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPR 1030
GGLP+ DHAE++A MAL + RF + + L++RIG++TGP AGV+GL
Sbjct: 229 GGLPKPRTDHAEAIADMALDMQQEIYRF--KREDNKILNIRIGINTGPVVAGVIGLKKFS 286
Query: 1031 YCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
Y L+GD VN ASRMES G IQ+SS+T E L Y L RG+ Q+KG+G M TYWL
Sbjct: 287 YDLWGDAVNIASRMESHGKIGEIQVSSSTYE--LLKHKYVLEKRGIVQVKGRGEMITYWL 344
Query: 1091 LGKE 1094
++
Sbjct: 345 KSRQ 348
>UniRef50_A0YN57 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 545
Score = 192 bits (469), Expect = 4e-47
Identities = 104/255 (40%), Positives = 156/255 (61%), Gaps = 5/255 (1%)
Query: 838 HDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSV 897
H R+ + + ++ S+ M+ S + + +QL++E++K+E+LL +LP S+
Sbjct: 294 HQEIRRTSQQMTVILLSSVIAMVT-LSVVIWRSFQSALKQLEVEQEKSERLLLNILPESI 352
Query: 898 AERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRV 957
A RL + FEEV++ F+DI GFT L+A+ + ++V+LLN++++ FD Q +
Sbjct: 353 ALRLKNKPETIADNFEEVTVLFADIAGFTQLSAKISPTELVNLLNEIFSEFDQITTQNNL 412
Query: 958 YKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTG 1017
K++TIGDAY+VVGGLP DHAE++A +AL + + F +H D L LRIG++TG
Sbjct: 413 EKIKTIGDAYLVVGGLPNPRSDHAEAIAKLALEMQNKLIEFNQKH--DHNLQLRIGINTG 470
Query: 1018 PCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLT 1077
P AGV+G Y L+GDTVN ASRMES G IQ++ T ++L YK RGL
Sbjct: 471 PVVAGVIGAKKFIYDLWGDTVNIASRMESHGIIGEIQVTEATYQRL--QDKYKFEKRGLI 528
Query: 1078 QIKGKGAMHTYWLLG 1092
+KGKG M TY+L G
Sbjct: 529 NVKGKGEMSTYFLKG 543
>UniRef50_A7BXS6 Cluster: Adenylate/guanylate cyclase; n=1; Beggiatoa
sp. PS|Rep: Adenylate/guanylate cyclase - Beggiatoa sp.
PS
Length = 430
Score = 188 bits (459), Expect = 6e-46
Identities = 102/239 (42%), Positives = 150/239 (62%), Gaps = 4/239 (1%)
Query: 856 MFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEV 915
++E L+K ++ L +E++K+E+LL +LP S+A+RL ++ + F V
Sbjct: 195 LYERLQKAEFEARFALQTEHGALKVEQEKSERLLLNILPLSIAQRLKQEEQIIADHFTNV 254
Query: 916 SIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ 975
++ F+DIVGFT L+ R +A ++V+LLN++++TFD +E++ + K++TIGDAYMVVGGLP
Sbjct: 255 TVLFADIVGFTQLSERLSAKKLVELLNEIFSTFDKLVEKHGLEKIKTIGDAYMVVGGLPV 314
Query: 976 RTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
D +A MAL + +F R+ D L +RIG+H G AGV+GL Y L+G
Sbjct: 315 PIEDSVTPIAEMALDMQEALAQFNRRYHYD--LKIRIGIHNGAVVAGVIGLKKFAYDLWG 372
Query: 1036 DTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
DTVNTASRMES G A IQ+S+ + L Y L RG +IKGKG M TY L G++
Sbjct: 373 DTVNTASRMESHGIAGCIQVSNRVYDAL--EDKYVLTKRGTIEIKGKGEMITYMLKGRQ 429
>UniRef50_A0YPF4 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 491
Score = 186 bits (454), Expect = 3e-45
Identities = 104/241 (43%), Positives = 151/241 (62%), Gaps = 11/241 (4%)
Query: 860 LEKYSNNLEELIRERTEQL-------DMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF 912
L + S LE+ + ERT +L E+KK+E+LL +LP+S+A RL G + F
Sbjct: 246 LRQTSEELEQRVFERTTELRRANIELSNEQKKSEELLLSILPQSIANRLKNGEVNIADCF 305
Query: 913 EEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGG 972
E +I F+DIVGFT L+ +VV +LN++++ FD ++Y++ K++TIGDAYMVVGG
Sbjct: 306 AEATILFADIVGFTTLSKEVKPEKVVRILNEIFSDFDRLCDRYKLEKIKTIGDAYMVVGG 365
Query: 973 LPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYC 1032
LP +DHA ++A MAL +L +F ++ + L +RIG+++GP AG++G Y
Sbjct: 366 LPNPRKDHAAAIAEMALDMLDDLNQFNAKN--NVKLEIRIGINSGPVIAGIIGTKKFIYD 423
Query: 1033 LFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
L+GD VNTASRMES G A IQ++ TT + L + RGL +IKGKG M TY L G
Sbjct: 424 LWGDAVNTASRMESHGIAGEIQLTETTFDYLQKE--FLFVERGLIEIKGKGKMRTYLLKG 481
Query: 1093 K 1093
+
Sbjct: 482 R 482
>UniRef50_A0YSC8 Cluster: Extracellular ligand-binding receptor; n=3;
Bacteria|Rep: Extracellular ligand-binding receptor -
Lyngbya sp. PCC 8106
Length = 1301
Score = 186 bits (453), Expect = 3e-45
Identities = 97/223 (43%), Positives = 141/223 (63%), Gaps = 4/223 (1%)
Query: 872 RERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAAR 931
R + L +E++K+E+LL +LPRS+AERL E F+ +I F+DIV FT +++
Sbjct: 1083 RRVLDALRIEQQKSERLLQNILPRSIAERLKQAPHSIAERFDHATIMFADIVDFTGFSSQ 1142
Query: 932 STAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHL 991
++VDLLN++++ FDA +++ + K++TIGD+YMVVGGLP DH +++A MAL +
Sbjct: 1143 IAPTELVDLLNEIFSAFDAFAQKHDLEKIKTIGDSYMVVGGLPTPKDDHVKAIAEMALDM 1202
Query: 992 LHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAW 1051
RF+ RH P LRIG++TGP AGV+G Y L+GD VN ASRMES G A
Sbjct: 1203 QREICRFQ-RH-DGLPFRLRIGINTGPVVAGVIGTRKFIYDLWGDAVNVASRMESHGEAG 1260
Query: 1052 RIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
+IQ++ T + L Y RG+ +KG G M TYWL G++
Sbjct: 1261 KIQVTKATYD--LLKDQYIFEKRGIIDVKGIGRMATYWLQGRK 1301
>UniRef50_UPI00005841ED Cluster: PREDICTED: similar to soluble
guanylyl cyclase beta 2 subunit; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to soluble guanylyl
cyclase beta 2 subunit - Strongylocentrotus purpuratus
Length = 645
Score = 186 bits (452), Expect = 4e-45
Identities = 101/223 (45%), Positives = 137/223 (61%), Gaps = 6/223 (2%)
Query: 838 HDVFRQMQRGRKINIVD-SMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRS 896
HD+ R + + I + + + LE+ L L+R+ L++EKKKT+ LL MLP+
Sbjct: 426 HDLTRDLILFNQQRIAEVELAKQLEQKKEELRTLMRD----LELEKKKTDTLLYSMLPKE 481
Query: 897 VAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYR 956
VA L G +VE EF++V+I FSDIV FT + ++ +Q+V LLN++Y FD +
Sbjct: 482 VANDLRDGKKVEAGEFQQVTISFSDIVRFTDMCSQCDPIQIVYLLNEMYVVFDELTSVHN 541
Query: 957 VYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT 1016
VYKVETIGDAYM VGGLP HAE VA L + + + + +R+G+HT
Sbjct: 542 VYKVETIGDAYMTVGGLPIPNETHAEQVACFGLGQVE-GVKSISSPVTGEIIQIRVGIHT 600
Query: 1017 GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTT 1059
GP AGVVG+ MPRYCLFGDTVNTASRMES ++ IS +T
Sbjct: 601 GPVVAGVVGVKMPRYCLFGDTVNTASRMESHSVPGKVHISPST 643
>UniRef50_UPI00015B5A8E Cluster: PREDICTED: similar to
ENSANGP00000003998; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000003998 - Nasonia
vitripennis
Length = 643
Score = 185 bits (450), Expect = 8e-45
Identities = 102/244 (41%), Positives = 148/244 (60%), Gaps = 12/244 (4%)
Query: 853 VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLG-SRVEP-E 910
++ MFE E+ S LE+ LD K K+++LL M+P+SVA+RL G S ++ E
Sbjct: 377 LEMMFEKAEQRSQELEQSYA----LLDRWKNKSDELLYSMIPQSVADRLRAGTSPLDTCE 432
Query: 911 EFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVV 970
FE +S+ F ++ F A+ +V +N +Y+ FD+ ++++ VYKVET+G YM
Sbjct: 433 SFESISVLFCELCDFNYSTIEG-AMDIVSSMNAVYSCFDSLMDKFNVYKVETVGRVYMAA 491
Query: 971 GGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPD-TPLHLRIGLHTGPCCAGVVGLTMP 1029
G P RT DHA +VA ++L L+ + R LP + +RIG+H+GP AGVVG+ +P
Sbjct: 492 SGAPDRTDDHAINVADVSLQLI---SQVRSLVLPSGLEIQIRIGIHSGPAVAGVVGIKVP 548
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYW 1089
RYC FGDTVNTASRM++T ++ IS T LL Y + SRG+ +KGKG M T+W
Sbjct: 549 RYCFFGDTVNTASRMQTTSLPGKVHISPHT-RALLPQDRYVIESRGIVSVKGKGNMETFW 607
Query: 1090 LLGK 1093
L K
Sbjct: 608 LRPK 611
>UniRef50_P92006 Cluster: Soluble guanylate cyclase gcy-34; n=7;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-34 -
Caenorhabditis elegans
Length = 686
Score = 184 bits (447), Expect = 2e-44
Identities = 100/255 (39%), Positives = 151/255 (59%), Gaps = 5/255 (1%)
Query: 837 LHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRS 896
LHD R + + + D L+ +NN E + T +L++E++KT+ +L MLPR
Sbjct: 380 LHDATRDLILLNQQRLSDVEVN-LQLEANN--EQLETMTHELEVERQKTDSILKDMLPRK 436
Query: 897 VAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYR 956
+A++L+ G +EP E+E ++ F D+ F + +V LLN+++ D +
Sbjct: 437 IAKQLLSGEHLEPCEYE-ATVMFCDLPAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRG 495
Query: 957 VYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT 1016
VYKVET+ D+YM V G+P T +HAE++ +AL ++ A R + + TP LRIGLH+
Sbjct: 496 VYKVETVSDSYMTVSGIPDYTSEHAENMCHVALGMMWEA-RSVMDPVNKTPFLLRIGLHS 554
Query: 1017 GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGL 1076
G AGVVG MPRYCLFG+TV AS+MES G A +IQ SS T K + G ++ RG
Sbjct: 555 GTIIAGVVGTKMPRYCLFGETVTLASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGR 614
Query: 1077 TQIKGKGAMHTYWLL 1091
+KG+G + TY+L+
Sbjct: 615 INVKGRGDVETYFLM 629
>UniRef50_A0YU66 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 833
Score = 183 bits (445), Expect = 3e-44
Identities = 100/241 (41%), Positives = 151/241 (62%), Gaps = 7/241 (2%)
Query: 855 SMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR-VEPEEFE 913
++ E+L ++ E + E E+L +E++K+E+LL +LP+ + E L + + E+++
Sbjct: 599 NLVEVLSVATDTTERRLAE--EELRIEREKSERLLLNILPQKIVETLKQEKQGLIAEKYD 656
Query: 914 EVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGL 973
EVSI F+D+V FTAL+ R T +Q+V LLN++++TFD E + K++TIGDAYM+ GL
Sbjct: 657 EVSILFADLVDFTALSERLTPIQLVKLLNEIFSTFDQLAEGLDLEKIKTIGDAYMMAAGL 716
Query: 974 PQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCL 1033
P DHAE++A MAL + + F + L +RIG+HTG AGV+G Y L
Sbjct: 717 PLPREDHAETIADMALSMQLVVDHFPFDY--GETLQIRIGIHTGTVVAGVIGTHKFIYDL 774
Query: 1034 FGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
+GDTVN A RMES+G +IQ+++ E+L Y RG IKGKG M TYWL+G+
Sbjct: 775 WGDTVNIAYRMESSGKPGKIQVTAAVYERL--KNEYIFEKRGEIPIKGKGKMMTYWLIGR 832
Query: 1094 E 1094
+
Sbjct: 833 Q 833
>UniRef50_Q4S4C7 Cluster: Chromosome 2 SCAF14738, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 2 SCAF14738, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 878
Score = 182 bits (442), Expect = 7e-44
Identities = 129/370 (34%), Positives = 194/370 (52%), Gaps = 55/370 (14%)
Query: 628 MQNLRQENVNPFIGCL-CEGRPALVFDECWRGSLEDVL-----MADDIKLDWTFRLSLLS 681
+Q + N+ F G + E VF+ RGSL VL ++ +DW F++S++
Sbjct: 255 LQQIDYYNLTKFYGTVKLEQGVFGVFEYGERGSLRYVLNDLVSYPEETFMDWEFKISVMY 314
Query: 682 DLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELL 741
D+ KGM YLH S ++ HGRL S NCVVD+R V+++TD+G + +P + L
Sbjct: 315 DIAKGMSYLHASDIQVHGRLKSTNCVVDNRMVVKITDFGCNSF----------LSPGKDL 364
Query: 742 WTAPELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCR-PP 800
WTAPE ++E +G +Q GDV+SFAII E+++R + S T E +KL R
Sbjct: 365 WTAPEHLKE--QG----TSQKGDVYSFAIIAHEIVLRKCTFYTASCTGRE--EKLSRIIT 416
Query: 801 PLIRPSVSMGAAPP---EAVSVMRQCWSEAPDLRPDF----NRLHDVFR----------- 842
+RP ++ E ++++ CW E P+ RPDF N L + R
Sbjct: 417 SNLRPDLNSDTDSEKELEVYTLIKSCWDEDPEKRPDFRKVENSLGKIIRSVLVSVSSGAP 476
Query: 843 -QMQRGRKINIVDSMFEMLEKYSNNL-----------EELIRERTEQLDMEKKKTEQLLN 890
+ + K++ + E Y +N+ E L+ ERT E+ + + L
Sbjct: 477 TEKRESGKMSCSKIHNQENESYVDNMIRRLQMYSRNLEHLVEERTALYKAERDRADNLNF 536
Query: 891 RMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDA 950
+LPR V + L VEPE +EEV+IYFSDIVGFT L ST ++VVD+LND+Y FD+
Sbjct: 537 MLLPRPVVKSLKESGMVEPELYEEVTIYFSDIVGFTTLCQYSTPMEVVDMLNDIYKGFDS 596
Query: 951 AIEQYRVYKV 960
++ + VYKV
Sbjct: 597 IVDLHDVYKV 606
Score = 77.4 bits (182), Expect = 2e-12
Identities = 34/63 (53%), Positives = 47/63 (74%), Gaps = 1/63 (1%)
Query: 957 VYKVETIGDAYMVVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLH 1015
+++VETIGDAYMV GLP+R + HA + MAL +LH G F++RHLP P+ +RIG+H
Sbjct: 637 LWQVETIGDAYMVASGLPKRNGNRHAVDICHMALDILHFMGTFQLRHLPGIPVWIRIGVH 696
Query: 1016 TGP 1018
+GP
Sbjct: 697 SGP 699
>UniRef50_A0YS29 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 657
Score = 182 bits (442), Expect = 7e-44
Identities = 98/235 (41%), Positives = 148/235 (62%), Gaps = 6/235 (2%)
Query: 858 EMLEKYSNNLEELIRERTEQ--LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEV 915
E+++ + L LI+ + Q L +K++TE+LL +LP+ +AERL + + F++V
Sbjct: 423 ELVKAVATQLGSLIQRKQAQQELQSQKEQTEKLLLNILPQPIAERLQKQPGIIADYFQDV 482
Query: 916 SIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ 975
S+ F+D+VGFT ++ +T Q++++LN +++ FD + Y + K++TIGDAYMVVGGLP
Sbjct: 483 SVLFADLVGFTDFSSEATPAQILEILNSIFSHFDQLSQHYGLEKIKTIGDAYMVVGGLPL 542
Query: 976 RTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
RDH ++A MAL + +F + LRIG+H GP AGV+GL+ Y L+G
Sbjct: 543 YHRDHLHAIAKMALDMQTNLTQFNQQ--TGNNFLLRIGIHAGPVVAGVIGLSKFSYDLWG 600
Query: 1036 DTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
DTVN ASRMES G + +IQ++S E+L + L RG IKGKG M TY+L
Sbjct: 601 DTVNVASRMESNGVSGQIQVTSEVYERLKDQFVFAL--RGSIPIKGKGEMTTYFL 653
>UniRef50_UPI000038D385 Cluster: COG2114: Adenylate cyclase, family 3
(some proteins contain HAMP domain); n=1; Nostoc
punctiforme PCC 73102|Rep: COG2114: Adenylate cyclase,
family 3 (some proteins contain HAMP domain) - Nostoc
punctiforme PCC 73102
Length = 433
Score = 179 bits (436), Expect = 4e-43
Identities = 96/219 (43%), Positives = 139/219 (63%), Gaps = 5/219 (2%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQV 937
+++ ++K+E+LL +LP +AE+L + F EV++ F+DIVGFT L+AR++ ++
Sbjct: 218 MELAQQKSERLLLNILPGMIAEQLKQQPTTIADSFMEVTVLFADIVGFTELSARTSPTEL 277
Query: 938 VDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGR 997
V+LLN ++ FD E ++V K++TIGDAYM V GLP +++DHA ++A MAL + +
Sbjct: 278 VELLNTIFCLFDQLAELHKVEKIKTIGDAYMAVAGLPNQSKDHALAIANMALDMQNAIAI 337
Query: 998 FRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISS 1057
F + + +RIG+ TGP AGV+GL Y L+GDTVNTASRMES G A IQ+
Sbjct: 338 FNAEN--NQLFSIRIGISTGPVVAGVIGLKKFAYDLWGDTVNTASRMESHGIAGNIQVCE 395
Query: 1058 TTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEGF 1096
T + L Y RGL Q+KGKG M TY +L K F
Sbjct: 396 ATYQ--LLKDKYLFDKRGLIQVKGKGEMMTY-ILKKVNF 431
>UniRef50_A7RN72 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 582
Score = 179 bits (435), Expect = 5e-43
Identities = 101/206 (49%), Positives = 129/206 (62%), Gaps = 7/206 (3%)
Query: 856 MFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEV 915
+ E LE+ SNNL+++ + E KK+T+ LL +LP+ VA +L L V E ++ V
Sbjct: 380 LVEKLEETSNNLKKVESKLIEH----KKRTDDLLYSILPKEVAAKLRLNQSVPAESYKTV 435
Query: 916 SIYFSDIVGFTALAARSTAV--QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGL 973
+I FSDIVGFTAL + V +V +LN LYT FD VYKVETIGDAYMVVGGL
Sbjct: 436 TILFSDIVGFTALCSNDKIVPMDIVKMLNRLYTYFDMLSGMNDVYKVETIGDAYMVVGGL 495
Query: 974 PQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCL 1033
P DHA+ VA+M L ++ A + + PL +RIG+HTGP AGVVG MPRYCL
Sbjct: 496 PHPCEDHADRVASMGLGMME-AADVVLSPVDREPLKIRIGIHTGPVMAGVVGKKMPRYCL 554
Query: 1034 FGDTVNTASRMESTGAAWRIQISSTT 1059
FG+TV A++MES RI IS T
Sbjct: 555 FGNTVTLANKMESGTQPGRINISIDT 580
>UniRef50_Q9VEU5 Cluster: Soluble guanylate cyclase 89Db; n=6;
Diptera|Rep: Soluble guanylate cyclase 89Db - Drosophila
melanogaster (Fruit fly)
Length = 669
Score = 179 bits (435), Expect = 5e-43
Identities = 99/241 (41%), Positives = 145/241 (60%), Gaps = 12/241 (4%)
Query: 853 VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF 912
++ MFE E+ S+ LE+ + E D K++ ++LL M+PR +AER+ + F
Sbjct: 435 LEIMFEKEEQRSDELEKSL----ELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSF 490
Query: 913 EEVSIYFSDIVGFTALAARS--TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVV 970
EEVS+ F +++ + + A+Q V LN +++ D I VYKVET+G YM V
Sbjct: 491 EEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAV 550
Query: 971 GGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPR 1030
G P HAE +AL ++ + + LP + +R+G+++GP AGVVG+ +PR
Sbjct: 551 SGAPDVNPLHAEHACDLALRVMK---KVKAHALPG--VAIRVGINSGPVVAGVVGMKVPR 605
Query: 1031 YCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
YCLFGDTVNTASRMES+ W IQ+S+ TA K+ GYK+ +RG ++KGKG M TYWL
Sbjct: 606 YCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKV-GYKVEARGFVKVKGKGEMETYWL 664
Query: 1091 L 1091
L
Sbjct: 665 L 665
>UniRef50_P33402 Cluster: Guanylate cyclase soluble subunit alpha-2;
n=39; Eumetazoa|Rep: Guanylate cyclase soluble subunit
alpha-2 - Homo sapiens (Human)
Length = 732
Score = 176 bits (428), Expect = 4e-42
Identities = 99/230 (43%), Positives = 141/230 (61%), Gaps = 11/230 (4%)
Query: 837 LHDVFRQMQR-GRKINIVDSMFEMLEKYSNNLEELIRERTEQ-LDMEKKKTEQLLNRMLP 894
+HD R + G + D + + ++K LE RT Q L+ EKKKT LL + P
Sbjct: 445 IHDATRDVILVGEQAKAQDGLKKRMDKLKATLE-----RTHQALEEEKKKTVDLLYSIFP 499
Query: 895 RSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQ 954
VA++L G +V+ +F++V++ FSDIVGFTA+ A+ T +QV+ +LN+LYT FD
Sbjct: 500 GDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGF 559
Query: 955 YRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPD-TPLHLRIG 1013
+YKVETIGDAY V GL +++ HA+ +A MAL ++ L+ PD P+ +RIG
Sbjct: 560 LDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLT---PDGRPIQMRIG 616
Query: 1014 LHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKL 1063
+H+G AGVVG+ MPRYCLFG+ V AS+ ES RI +S TT + L
Sbjct: 617 IHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
>UniRef50_UPI00015B5C60 Cluster: PREDICTED: similar to soluble
guanylyl cyclase alpha 1 subunit; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to soluble guanylyl
cyclase alpha 1 subunit - Nasonia vitripennis
Length = 705
Score = 175 bits (427), Expect = 5e-42
Identities = 94/239 (39%), Positives = 139/239 (58%), Gaps = 7/239 (2%)
Query: 837 LHDVFRQMQR-GRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPR 895
LHD R + G + D + ++K +++EE R +D E++K LL+ + P
Sbjct: 422 LHDATRDVILVGEQARAQDGLRRRMDKLKSSIEETNRA----VDAEREKNVSLLHLIFPP 477
Query: 896 SVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQY 955
+A+RL LG +E + + +V++ FSDIVGFTA+ + +T + V+++L +LY FD+ Q
Sbjct: 478 DIAKRLWLGETIEAKNYADVTMLFSDIVGFTAICSTATPMMVINMLQNLYQQFDSYCGQL 537
Query: 956 RVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLH 1015
VYKVETIGDAY V GL + T HA+ +A M L ++ + P+ +RIG+H
Sbjct: 538 DVYKVETIGDAYCVACGLHRNTSTHAQQIAWMGLKMIQTCTQHSTH--DGKPIKMRIGIH 595
Query: 1016 TGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSR 1074
TG AGVVG MPRYCLFG V A++ ES+ R+ IS TT E L+ G+ L R
Sbjct: 596 TGMVLAGVVGKKMPRYCLFGHNVTIANKFESSSEPLRVNISPTTYEFLMQGPGFILEER 654
>UniRef50_Q8YZ26 Cluster: Adenylate cyclase; n=1; Nostoc sp. PCC
7120|Rep: Adenylate cyclase - Anabaena sp. (strain PCC
7120)
Length = 472
Score = 175 bits (427), Expect = 5e-42
Identities = 101/249 (40%), Positives = 150/249 (60%), Gaps = 14/249 (5%)
Query: 853 VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE- 911
V + + + K + L+E + ++L +E+ ++E+LL +LP+++AERL S+ P+
Sbjct: 224 VQKIQDSVTKLTTALQET-QMTAKRLAVEQAQSEKLLLNILPQAIAERLKQ-SQPSPQTS 281
Query: 912 -------FEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIG 964
F + ++ F+DIVGFT L+ R ++VDLLN +++ FD E Y + K++TIG
Sbjct: 282 QMMIADGFSDATVMFADIVGFTDLSGRIPPQRLVDLLNQIFSRFDLLAESYNLEKIKTIG 341
Query: 965 DAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVV 1024
DAYMVVGGLP DHA ++A M L +L +F + +RIG+++GP AGV+
Sbjct: 342 DAYMVVGGLPNPRPDHAIAIAHMGLDILDAIAQFNLD--TGEQFKIRIGINSGPVVAGVI 399
Query: 1025 GLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGA 1084
G+ Y L+GDTVN ASRMES G RI +S+ + E L + RG+T IKGKG
Sbjct: 400 GIKKFIYDLWGDTVNIASRMESHGTPNRIHVSAASHE--LLKDSFLFEDRGVTAIKGKGD 457
Query: 1085 MHTYWLLGK 1093
M TYWL GK
Sbjct: 458 MQTYWLKGK 466
>UniRef50_Q9VA09 Cluster: CG1470-PA; n=6; Diptera|Rep: CG1470-PA -
Drosophila melanogaster (Fruit fly)
Length = 787
Score = 175 bits (425), Expect = 8e-42
Identities = 109/295 (36%), Positives = 158/295 (53%), Gaps = 21/295 (7%)
Query: 814 PEAVSVMRQCWSEA---PDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEEL 870
PE ++ QC+ DL + DV R + ++ FE K + NLE L
Sbjct: 424 PETDRILFQCYPSVMNLDDLTKKGLYISDVPLH-DAARDLVLLSEKFEAEYKLTKNLEML 482
Query: 871 ---IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTA 927
+++ L+ EK+KT++LL +LP+SVA L V P+ ++ V++ FS IVGF
Sbjct: 483 TDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQ 542
Query: 928 LAARST----AVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTRDH 980
A +T A+++V +LN+LYT FDA + R VYKVET+GD YM V GLP DH
Sbjct: 543 YCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDH 602
Query: 981 AESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNT 1040
A+ +A +AL ++ +A + + P+ + IG+H+G GV+G +PRYCLFG+TVN
Sbjct: 603 AKCMARVALDMMDMAKNVK---MGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNL 659
Query: 1041 ASRMESTGAAWRIQISSTTAEKLLAA----GGYKLRSRGLTQIKGKGAMHTYWLL 1091
SR E+TG RI +S T L A + L RG +KGK W L
Sbjct: 660 TSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFL 714
>UniRef50_Q9ERL9 Cluster: Guanylate cyclase soluble subunit alpha-3;
n=16; Coelomata|Rep: Guanylate cyclase soluble subunit
alpha-3 - Mus musculus (Mouse)
Length = 691
Score = 175 bits (425), Expect = 8e-42
Identities = 91/220 (41%), Positives = 131/220 (59%), Gaps = 2/220 (0%)
Query: 860 LEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYF 919
L+K L+ + + L+ EKK+T LL + P VA++L G V+ ++F EV++ F
Sbjct: 425 LKKRLGKLKATLEHAHQALEEEKKRTVDLLCSIFPSEVAQQLWQGQIVQAKKFSEVTMLF 484
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD 979
SDIVGFTA+ ++ + +QV+ +LN LYT FD + VYKVETIGDAY V GGL + +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDT 544
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
HA +A MAL ++ L+ H P+ +RIGLH+G AGVVG+ MPRYCLFG+ V
Sbjct: 545 HAVQIALMALKMMELSNEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 602
Query: 1040 TASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQI 1079
A++ ES +I +S TT L G+ R ++
Sbjct: 603 LANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>UniRef50_Q7Q9W6 Cluster: ENSANGP00000003998; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000003998 - Anopheles gambiae
str. PEST
Length = 649
Score = 174 bits (423), Expect = 1e-41
Identities = 101/237 (42%), Positives = 136/237 (57%), Gaps = 10/237 (4%)
Query: 859 MLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP--EEFEEVS 916
M E+ EEL D K++ ++LL M+PRS+AERL G + FEEV+
Sbjct: 414 MCEREEQRAEEL-ETSLALADSWKRQGDELLYSMIPRSIAERLREGQNPHETCQSFEEVT 472
Query: 917 IYFSDIVG-FTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ 975
+ F+++ T + A+ V+ LN ++ FD I YKVET+G YM V G P
Sbjct: 473 VLFAEVQETITGDDSIKYAMTTVNTLNAAFSAFDELIHSPMAYKVETVGKVYMAVSGAPD 532
Query: 976 RTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
HA+ +A +AL +LH +R L + ++IG H+GP AG+VGL +PRYCLFG
Sbjct: 533 INPFHAQHMADLALDMLH-----SIRQLNLPGVGVKIGFHSGPIVAGIVGLKVPRYCLFG 587
Query: 1036 DTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
DTVNTASRMES+G IQ+S TA+KL GY L RG +KGKG M T+WL G
Sbjct: 588 DTVNTASRMESSGETDCIQVSGYTAQKLKKL-GYVLAYRGKVAVKGKGDMETFWLQG 643
>UniRef50_Q02108 Cluster: Guanylate cyclase soluble subunit alpha-3;
n=12; Amniota|Rep: Guanylate cyclase soluble subunit
alpha-3 - Homo sapiens (Human)
Length = 690
Score = 173 bits (422), Expect = 2e-41
Identities = 91/220 (41%), Positives = 131/220 (59%), Gaps = 2/220 (0%)
Query: 860 LEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYF 919
L+K L+ + + + L+ EKKKT LL + P VA++L G V+ ++F V++ F
Sbjct: 425 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 484
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD 979
SDIVGFTA+ ++ + +QV+ +LN LYT FD + VYKVETIGDAY V GGL + +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDT 544
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
HA +A MAL ++ L+ H P+ +RIGLH+G AGVVG+ MPRYCLFG+ V
Sbjct: 545 HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 602
Query: 1040 TASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQI 1079
A++ ES +I +S TT L G+ R ++
Sbjct: 603 LANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
>UniRef50_Q7ZSZ5 Cluster: Soluble guanylyl cyclase alpha2 subunit;
n=5; Percomorpha|Rep: Soluble guanylyl cyclase alpha2
subunit - Oryzias latipes (Medaka fish) (Japanese
ricefish)
Length = 805
Score = 172 bits (419), Expect = 4e-41
Identities = 99/230 (43%), Positives = 137/230 (59%), Gaps = 11/230 (4%)
Query: 837 LHDVFRQMQR-GRKINIVDSMFEMLEKYSNNLEELIRERTEQ-LDMEKKKTEQLLNRMLP 894
+HD R + G + D + + ++K LE RT Q L+ EK++T LL + P
Sbjct: 514 IHDATRDVILVGEQAKAQDGLKKRMDKLKATLE-----RTHQALEEEKRRTVDLLYSIFP 568
Query: 895 RSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQ 954
VA++L G V +F++V++ FSDIVGFTA+ A T +QV+ +LN+LYT FD
Sbjct: 569 GDVAQKLWQGQPVPARKFDDVTMLFSDIVGFTAVCAHCTPMQVISMLNELYTRFDYQCGI 628
Query: 955 YRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPD-TPLHLRIG 1013
VYK+ETIGDAY V GGL ++ HA+ +A MAL ++ L+ PD P+ LRIG
Sbjct: 629 LDVYKIETIGDAYCVAGGLHKKVDSHAKPIAHMALKMMELSEEVLT---PDGKPIKLRIG 685
Query: 1014 LHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKL 1063
+HTG AGVVG+ MPRYCLFG+ V AS+ ES I +S TT + L
Sbjct: 686 IHTGSVLAGVVGVKMPRYCLFGNNVTLASKFESGSHPRCINVSPTTYQLL 735
>UniRef50_Q86C56 Cluster: Soluble guanylate cyclase gcy-31; n=4;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-31 -
Caenorhabditis elegans
Length = 702
Score = 172 bits (418), Expect = 6e-41
Identities = 91/229 (39%), Positives = 138/229 (60%), Gaps = 4/229 (1%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP--EEFEEVSIYFSDIVGFTAL 928
+RE +L E+++T++LL +MLP+SVA +L G E F+ V+I F+DIV FT +
Sbjct: 388 MRENMNRLKKERRRTDKLLYQMLPKSVANQLRHGESAVACCERFDSVTILFTDIVEFTKM 447
Query: 929 AARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMA 988
+ T ++V++ L +YT FD I+ + VYKVETIGDAYMVV G P +T AE + A
Sbjct: 448 CSSLTPLEVIEFLKVIYTNFDKIIDTHGVYKVETIGDAYMVVSGAPTKTEHDAEFILDCA 507
Query: 989 LHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
L AG+ + + +R G+H+G AGVVGL+MPRYCLFG+TV A++ME
Sbjct: 508 SQFLVEAGKMVNMNNKIHKIDIRAGVHSGSVVAGVVGLSMPRYCLFGETVYVANKMEQNS 567
Query: 1049 AAWRIQISSTTAEKLLAA--GGYKLRSRGLTQIKGKGAMHTYWLLGKEG 1095
+ +I +S TT K+ + G Y+ R +IK + T++++ + G
Sbjct: 568 SPMKILVSETTHNKIEESDPGLYQFERREEIEIKDDQTIQTFFVVSRHG 616
>UniRef50_Q10XK8 Cluster: Adenylate/guanylate cyclase precursor; n=1;
Trichodesmium erythraeum IMS101|Rep: Adenylate/guanylate
cyclase precursor - Trichodesmium erythraeum (strain
IMS101)
Length = 1209
Score = 171 bits (416), Expect = 1e-40
Identities = 94/224 (41%), Positives = 140/224 (62%), Gaps = 5/224 (2%)
Query: 872 RERTEQ-LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAA 930
R++ EQ L +E+ K+E+LL +LP+ +A++L + E F+EV++ F+D+VGFT LA+
Sbjct: 987 RKKVEQALLLEQGKSEKLLLNILPKPIADKLKENQDIIAEGFDEVTVLFADLVGFTQLAS 1046
Query: 931 RSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALH 990
++V LN++++ FD E+Y + K++TIGDAYMVVGGLP +HAE++A +A+
Sbjct: 1047 SVYPKRLVYWLNEIFSKFDLLAEKYGLEKIKTIGDAYMVVGGLPTPMENHAEAIALIAID 1106
Query: 991 LLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
+ F H +RIG++TGP AGV+G Y L+GDTVN ASRMES G
Sbjct: 1107 MREELAHF--AHKSKQDFLIRIGINTGPVVAGVIGRKKFIYDLWGDTVNIASRMESQGIP 1164
Query: 1051 WRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
IQ++ T + + + RGL IKGKG M TY+L GK+
Sbjct: 1165 GVIQVTEATYQ--ILKHKFLFTERGLIHIKGKGYMKTYFLQGKK 1206
>UniRef50_Q07093 Cluster: Head-specific guanylate cyclase; n=8;
Endopterygota|Rep: Head-specific guanylate cyclase -
Drosophila melanogaster (Fruit fly)
Length = 676
Score = 167 bits (406), Expect = 2e-39
Identities = 93/235 (39%), Positives = 137/235 (58%), Gaps = 7/235 (2%)
Query: 837 LHDVFRQMQR-GRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPR 895
LHD R++ G + D + ++K N++EE T+ E+KK LL+ + P
Sbjct: 390 LHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTK----ERKKNVSLLHLIFPA 445
Query: 896 SVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQY 955
+AE+L LGS ++ + + +V+I FSDIVGFT++ +R+T V+ +L LY FD + +
Sbjct: 446 EIAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFF 505
Query: 956 RVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLH 1015
VYKVETIGDAY V GL + + A VA MAL ++ + + H + +RIGLH
Sbjct: 506 DVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMIDACSK-HITH-DGEQIKMRIGLH 563
Query: 1016 TGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYK 1070
TG AGVVG MPRYCLFG +V A++ ES A +I +S TT + L G++
Sbjct: 564 TGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFE 618
>UniRef50_Q02153 Cluster: Guanylate cyclase soluble subunit beta-1;
n=40; Coelomata|Rep: Guanylate cyclase soluble subunit
beta-1 - Homo sapiens (Human)
Length = 619
Score = 166 bits (404), Expect = 3e-39
Identities = 102/270 (37%), Positives = 148/270 (54%), Gaps = 19/270 (7%)
Query: 837 LHDVFRQMQR-GRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPR 895
LHD R + G + + + LE ++ L+ +R L+ EKKKT+ LL +LP
Sbjct: 345 LHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRA----LEDEKKKTDTLLYSVLPP 400
Query: 896 SVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARST----AVQVVDLLNDLYTTFDAA 951
SVA L V + ++ V+I FS IVGF A ++ A+++V+LLNDLYT FD
Sbjct: 401 SVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTL 460
Query: 952 IEQYR---VYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPL 1008
+ + VYKVET+GD YM V GLP+ HA S+ +AL ++ +AG+ +V +
Sbjct: 461 TDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQV---DGESV 517
Query: 1009 HLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGG 1068
+ IG+HTG GV+G MPRYCLFG+TVN SR E+TG +I +S T L++
Sbjct: 518 QITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPEN 577
Query: 1069 ----YKLRSRGLTQIKGKGAMHTYWLLGKE 1094
+ L RG +KGK W L ++
Sbjct: 578 SDPQFHLEHRGPVSMKGKKEPMQVWFLSRK 607
>UniRef50_Q8F690 Cluster: Adenylate cyclase; n=4; Leptospira|Rep:
Adenylate cyclase - Leptospira interrogans
Length = 492
Score = 164 bits (399), Expect = 1e-38
Identities = 89/227 (39%), Positives = 136/227 (59%), Gaps = 5/227 (2%)
Query: 869 ELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTAL 928
E I + L+ E++K+E LL +LP+S AERL G V + ++ ++ F+DIVGF+ L
Sbjct: 270 EKINILNKGLEKERQKSESLLLNILPKSTAERLKAGEVVIADYIKKSTVLFADIVGFSKL 329
Query: 929 AAR-STAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATM 987
+ + T Q+V++LN ++T FD +Y++ K++TIGD YM+ GG+P T DH E +A
Sbjct: 330 STQIPTPNQLVEILNQIFTCFDDIASKYQLEKIKTIGDCYMMAGGIPIATEDHVEKIALA 389
Query: 988 ALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
+ ++ G ++ ++RIG+HTG AGV+G Y L+GD+VNTASRMES
Sbjct: 390 GIDMIQ--GLKDLQKSWKYEFNIRIGIHTGDVVAGVIGKNKFVYDLWGDSVNTASRMESH 447
Query: 1048 GAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
G RI S E + + RG+ +KGKG M T++LLGK+
Sbjct: 448 GEPGRIHCSEAVYESIKDL--FLFEERGVIPVKGKGPMRTFFLLGKK 492
>UniRef50_A5P0P3 Cluster: Response regulator receiver protein; n=1;
Methylobacterium sp. 4-46|Rep: Response regulator
receiver protein - Methylobacterium sp. 4-46
Length = 531
Score = 164 bits (398), Expect = 2e-38
Identities = 87/211 (41%), Positives = 128/211 (60%), Gaps = 4/211 (1%)
Query: 882 KKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLL 941
+++ E+LL +LPR + R+ G + F +V++ F D+VGFT LA R T VDLL
Sbjct: 318 REREERLLLNVLPRPILARMRNGEAAIADRFAQVTVLFCDLVGFTPLAGRLTPGGTVDLL 377
Query: 942 NDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVR 1001
+ +++ FD ++ + V K++TIGDAYM GG+P+ T DHA +A +A + +A V
Sbjct: 378 SRVFSAFDRSVARRGVEKIKTIGDAYMAAGGIPETTPDHARRIALLAFDM--MADVEEVG 435
Query: 1002 HLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAE 1061
L +R+G+H+G AGV+G + Y ++GD+VN A+RMES G A RI IS +T
Sbjct: 436 RALGVELAVRVGIHSGEAVAGVIGQSRFAYDVWGDSVNIAARMESHGQAGRIHISESTRR 495
Query: 1062 KLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
L G + RG+T IKGKG M TY+L G
Sbjct: 496 AL--GGDFFCTPRGVTHIKGKGPMETYFLDG 524
>UniRef50_A0YQ82 Cluster: Adenylate cyclase; n=1; Lyngbya sp. PCC
8106|Rep: Adenylate cyclase - Lyngbya sp. PCC 8106
Length = 442
Score = 164 bits (398), Expect = 2e-38
Identities = 93/245 (37%), Positives = 137/245 (55%), Gaps = 5/245 (2%)
Query: 851 NIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVE-P 909
N+ +++ L + N + E +QL +E++++E L+ +LP +A+RL
Sbjct: 201 NLSVYLYDRLARSEFNSRLALEEAYQQLQVEQERSEALILNILPVPIAQRLKQKPVTTIA 260
Query: 910 EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMV 969
+ F + + F DIVGFT L+ + ++V LL +++ FD +++ + K++TIGDAYMV
Sbjct: 261 DNFTDAGVLFGDIVGFTELSGKMPPAELVQLLGQIFSRFDHLADKHNLEKIKTIGDAYMV 320
Query: 970 VGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMP 1029
V GLP D+AE +A MAL + F + +RIG+ GP AGV+GL
Sbjct: 321 VSGLPIPKEDYAERIADMALDMQKTILEFNAE--TERKFQMRIGIAIGPVVAGVIGLRKF 378
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYW 1089
Y L+GDTVN ASRMES G A IQ++ TT L Y L RG +KGKG M TY
Sbjct: 379 IYDLWGDTVNIASRMESHGIANEIQVTETTYHAL--KDDYSLEKRGTILVKGKGEMTTYL 436
Query: 1090 LLGKE 1094
L GK+
Sbjct: 437 LKGKK 441
>UniRef50_Q7YWK7 Cluster: Soluble guanylate cyclase subunit; n=1;
Aplysia californica|Rep: Soluble guanylate cyclase
subunit - Aplysia californica (California sea hare)
Length = 801
Score = 164 bits (398), Expect = 2e-38
Identities = 83/187 (44%), Positives = 120/187 (64%), Gaps = 2/187 (1%)
Query: 860 LEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYF 919
L+K L++ I + +D EK+K LL + P ++A++L G +VEP ++V++ F
Sbjct: 605 LKKRMEQLKKSIETASHAVDEEKQKNVDLLLEIFPPTIAQKLWRGEQVEPMTVDDVTMLF 664
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD 979
SDIVGFTA+ + +T +QVVD+LN LYT FD VYK+ETIGDAY V GGL +R+
Sbjct: 665 SDIVGFTAICSTATPMQVVDMLNSLYTHFDQFCVDIDVYKIETIGDAYCVAGGLHRRSAY 724
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
HA+ +A MA+ + +A + + +RIG+HTG AGVVG MPRYCLFG+ V+
Sbjct: 725 HAQQIAWMAVKM--MAAAENEKSHDGNVIKMRIGIHTGRVLAGVVGRKMPRYCLFGNNVS 782
Query: 1040 TASRMES 1046
A++ ES
Sbjct: 783 IANKFES 789
>UniRef50_P0A4Y1 Cluster: Adenylate cyclase; n=15; Mycobacterium|Rep:
Adenylate cyclase - Mycobacterium bovis
Length = 443
Score = 164 bits (398), Expect = 2e-38
Identities = 86/218 (39%), Positives = 136/218 (62%), Gaps = 5/218 (2%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSR-VEPEEFEEVSIYFSDIVGFTALAARSTAVQ 936
++ E ++E LL MLP S+AERL R + ++++E S+ F+DIVGFT A+ +
Sbjct: 212 MEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPAD 271
Query: 937 VVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAG 996
+V L+ LY+ FD ++Q+ + K++ GD+YMVV G+P+ DH +++A AL + ++A
Sbjct: 272 LVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAA 331
Query: 997 RFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
+++ P+ LR+GL TGP AGVVG Y ++GD VN ASRMEST + +IQ+
Sbjct: 332 --QLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVP 389
Query: 1057 STTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
E+L + LR RG +KGKG M T++L+G++
Sbjct: 390 DEVYERL--KDDFVLRERGHINVKGKGVMRTWYLIGRK 425
>UniRef50_Q4TB76 Cluster: Chromosome undetermined SCAF7184, whole
genome shotgun sequence; n=2; Euteleostomi|Rep:
Chromosome undetermined SCAF7184, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 182
Score = 163 bits (395), Expect = 4e-38
Identities = 75/131 (57%), Positives = 95/131 (72%), Gaps = 1/131 (0%)
Query: 909 PEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYM 968
P +V+I+FSDIVGFT+++A + +QVV++LNDLY FD I+ Y VYKVETIGDAYM
Sbjct: 1 PPRLSQVTIFFSDIVGFTSISASCSPLQVVEMLNDLYMCFDTRIDSYDVYKVETIGDAYM 60
Query: 969 VVGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLT 1027
VV GLP R D HA+ +A MAL L+ + + H+P+ L LR G+HTGPC A +VG
Sbjct: 61 VVSGLPDRNGDRHADEIAKMALDLVAAVRQVSIPHMPEHRLQLRAGIHTGPCVARIVGYK 120
Query: 1028 MPRYCLFGDTV 1038
MPRYCLFGDTV
Sbjct: 121 MPRYCLFGDTV 131
>UniRef50_Q1H0Z8 Cluster: Adenylate/guanylate cyclase; n=1;
Methylobacillus flagellatus KT|Rep: Adenylate/guanylate
cyclase - Methylobacillus flagellatus (strain KT / ATCC
51484 / DSM 6875)
Length = 426
Score = 161 bits (391), Expect = 1e-37
Identities = 97/220 (44%), Positives = 131/220 (59%), Gaps = 7/220 (3%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERL--MLGSRVEPEEFEEVSIYFSDIVGFTALAARST 933
E L +EK ++EQLL +LP SVA+RL R+ + + V+I F+DIV FT ++A T
Sbjct: 202 EALAVEKSRSEQLLRSILPESVAKRLHETQCGRIA-DSHDAVTILFADIVNFTQISAGMT 260
Query: 934 AVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLH 993
VVDLLN +++ FD QY V K++TIGDAYMV+ G P DHA +A MAL +
Sbjct: 261 PAAVVDLLNHVFSRFDQLAAQYGVEKIKTIGDAYMVIAGAPSPRTDHAHVMADMALEVPA 320
Query: 994 LAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRI 1053
L +V PL +RIG+++G AG++G T Y L+GD VN ASRME+TG I
Sbjct: 321 LLD--KVSREIGMPLAMRIGMNSGAVVAGIIGNTRFSYDLWGDAVNIASRMETTGLPNEI 378
Query: 1054 QISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
Q+S+ T E L A Y R +KGKG + TY L G+
Sbjct: 379 QVSAATYELLKA--DYCFEPRCGVDVKGKGKVVTYLLKGR 416
>UniRef50_P90895 Cluster: Soluble guanylate cyclase gcy-33; n=2;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-33 -
Caenorhabditis elegans
Length = 945
Score = 161 bits (391), Expect = 1e-37
Identities = 93/247 (37%), Positives = 141/247 (57%), Gaps = 6/247 (2%)
Query: 854 DSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP-EEF 912
D++ MLE E++ E T ++ KK LL +M+P VA+ +M V+ E F
Sbjct: 375 DTLKTMLENEKRR-SEVLTEMTREISEAKKTARTLLTQMMPYEVAQTMMRSGSVDHCEAF 433
Query: 913 EEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGG 972
E VSI F + F+ ++ A +VV+LLN +Y+ D+ ++ + VYKVETIG++YM+ G
Sbjct: 434 ECVSIGFIRVCDFSKISLFIEAFEVVNLLNTIYSHLDSIVDTHGVYKVETIGESYMISAG 493
Query: 973 LPQRTRDHAESVATMALHLL-HLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRY 1031
P R AE V+ L ++ H+ H + ++ G+ TGP GVVG+ PRY
Sbjct: 494 CPYRDDYDAEMVSDCCLEMVSHIKSFEYQSHDAVKKVLIKCGIFTGPVVGGVVGVRTPRY 553
Query: 1032 CLFGDTVNTASRMESTG-AAWRIQISSTTAEKL--LAAGGYKLRSRGLTQIKGKGAMHTY 1088
CLFGDTVNTASRMES+ IQI T +++ A+G ++++ +G +KGKG M Y
Sbjct: 554 CLFGDTVNTASRMESSNQTPMTIQIGQRTKDRVEKQASGAFRIKPKGNVFVKGKGDMRVY 613
Query: 1089 WLLGKEG 1095
+ K+G
Sbjct: 614 EIEKKKG 620
>UniRef50_Q1NSQ3 Cluster: Adenylate cyclase; n=1; delta
proteobacterium MLMS-1|Rep: Adenylate cyclase - delta
proteobacterium MLMS-1
Length = 480
Score = 161 bits (390), Expect = 1e-37
Identities = 88/222 (39%), Positives = 131/222 (59%), Gaps = 3/222 (1%)
Query: 872 RERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAAR 931
RE+ +L ++ ++ E+LL +LP +A RL G + + E V++ F D+ GFT +A
Sbjct: 250 REKERELALQNQENERLLANILPGPIALRLKSGEELIADAHELVTVIFIDMTGFTRYSAS 309
Query: 932 STAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHL 991
A +VVD LN ++ D +YR+ K++TIGDAYM+VGGL +H VA MAL L
Sbjct: 310 HPARRVVDTLNRIFRMIDDLTLKYRLEKIKTIGDAYMMVGGLDPMDDNHPRRVADMALEL 369
Query: 992 LHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAW 1051
+ R + + L T +R+G+ TGP +GV+G Y L+GDTVN A+R+ES+
Sbjct: 370 MREFDRLK-QELQVTDFSIRVGIATGPVVSGVIGSVKFAYDLWGDTVNAANRLESSALPG 428
Query: 1052 RIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
RI ++ A +L Y+ RG +IKGKG MHT +LLG+
Sbjct: 429 RIHCNARFAHRL--QEHYRFEDRGEIEIKGKGVMHTCFLLGQ 468
>UniRef50_A7S7B2 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 584
Score = 161 bits (390), Expect = 1e-37
Identities = 91/247 (36%), Positives = 142/247 (57%), Gaps = 7/247 (2%)
Query: 837 LHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRS 896
+HD ++M + + +++ +E + E +L+ E++++E LL RM+P+
Sbjct: 342 MHDTSQEMALSGIKPLPQLEYARDQQFEQGIE--LEENMRKLEEERQRSEDLLYRMVPKP 399
Query: 897 VAERLMLGSR-VEP-EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQ 954
+AERL G ++ EEF+ ++ FS + GFT++ R A+Q V L+N+L+ FD E+
Sbjct: 400 IAERLKRGGNPIDTCEEFDAATVLFSYMDGFTSICTRLNAMQAVTLINNLFIKFDLLTEK 459
Query: 955 YRVYKVETIGDA-YMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIG 1013
+ VYK ET+GDA YM V G+P RT HAE +A MAL +L A + + P+ + +G
Sbjct: 460 HNVYKFETLGDALYMAVSGVPVRTEHHAEPMAAMALDMLK-AVQLVKDPITKKPMTITVG 518
Query: 1014 LHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRS 1073
+H+GP AG+VG +YCLFGDTVN ASR+ +T RI IS E L +
Sbjct: 519 IHSGPVAAGLVGERTLQYCLFGDTVNIASRLRTTALPMRIHISENCRE-CLEESDFITEF 577
Query: 1074 RGLTQIK 1080
RG ++K
Sbjct: 578 RGEIELK 584
>UniRef50_A1ZSW5 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 408
Score = 160 bits (388), Expect = 3e-37
Identities = 85/223 (38%), Positives = 127/223 (56%), Gaps = 4/223 (1%)
Query: 870 LIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALA 929
LI+ + EQ+ EK K+++LL +LP +AE L R E + VS+ F+DI GFT A
Sbjct: 155 LIQRKKEQIKQEKAKSDELLLNILPEDIAEELKASGRSEARNYNTVSVLFADIKGFTTAA 214
Query: 930 ARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMAL 989
+ +A VV L +T FD +E+Y + K++TIGDAYM GG+PQ ++ + AL
Sbjct: 215 EKMSAADVVKHLEYYFTAFDEIMEKYELEKIKTIGDAYMAAGGIPQPNTSNSLEMVCAAL 274
Query: 990 HLLHLAGRFRV--RHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
+ + + + R D LR+G++TGP AGV+G Y ++GDTVNTASRMES
Sbjct: 275 EMQNFMRQHKEARRSSNDLCWELRLGINTGPLVAGVIGKNKFAYDVWGDTVNTASRMESN 334
Query: 1048 GAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
G ++ IS T + L ++ RG +KGKG + Y++
Sbjct: 335 GEVNKVNISGVTHQ--LVKDYFECEYRGKVNVKGKGEVDMYFV 375
>UniRef50_Q89SW2 Cluster: Two-component hybrid sensor and regulator;
n=3; Bacteria|Rep: Two-component hybrid sensor and
regulator - Bradyrhizobium japonicum
Length = 527
Score = 159 bits (386), Expect = 4e-37
Identities = 88/214 (41%), Positives = 127/214 (59%), Gaps = 4/214 (1%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQ 936
+++ E K E+LL +LPR V RL G + + FE VS+ F+D+VGFT ++R T
Sbjct: 315 RIEEETAKFERLLLTILPRQVIGRLNHGEAMIADRFEGVSVLFADLVGFTEHSSRVTPAA 374
Query: 937 VVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAG 996
+V+ LN L++ FDA + V K++TIGDAYM V GLP D ++A MAL ++ G
Sbjct: 375 MVEYLNRLFSEFDALARELGVEKIKTIGDAYMAVAGLPDPNPDAIAAIAKMALGMIDRLG 434
Query: 997 RFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
R H PL +RIG+H+GP AG++G Y ++GDTVN ASR+E+ RI +S
Sbjct: 435 RVN-SHF-GWPLQIRIGIHSGPVVAGIIGAHRFIYDVWGDTVNVASRLEAYSLPNRIHVS 492
Query: 1057 STTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
A L+ G + L RG +KGKG + T++L
Sbjct: 493 RDIARHLV--GRFALEPRGSIDVKGKGKLETFFL 524
>UniRef50_Q95NK5 Cluster: Soluble guanylyl cyclase beta1; n=2;
Strongylocentrotidae|Rep: Soluble guanylyl cyclase beta1
- Hemicentrotus pulcherrimus (Sea urchin)
Length = 604
Score = 159 bits (385), Expect = 6e-37
Identities = 98/257 (38%), Positives = 145/257 (56%), Gaps = 13/257 (5%)
Query: 848 RKINIVDSMFEMLEKYSNNLEEL---IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLG 904
R + ++ F+ K + LE L +++ +++ EKKKT++LL +LP SVA L
Sbjct: 343 RDLVLISERFDEEYKLTQKLEILTDKLQQTYREIENEKKKTDRLLYSILPPSVANELRHH 402
Query: 905 SRVEPEEFEEVSIYFSDIVGFTALAARST--AVQVVDLLNDLYTTFDAAIEQYR-VYKVE 961
V ++FE V++ FS I GF R + A+++V LLN +YT FD +E VYKVE
Sbjct: 403 RPVPAKKFECVTLMFSGIFGFGDFCRRYSHDAMKIVSLLNSVYTKFDVLMENNPDVYKVE 462
Query: 962 TIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCA 1021
T+GD YM V GLP DHA+ +A MAL + L+ + P+ + IG+++G
Sbjct: 463 TVGDKYMAVSGLPVPCADHAKCIAKMALEMKELSADVIME---GDPIVITIGVYSGEVVT 519
Query: 1022 GVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLL----AAGGYKLRSRGLT 1077
GVVG MPRYCLFG+TVN SR E+TG +I I+ T + L+ A ++ RGL
Sbjct: 520 GVVGQRMPRYCLFGNTVNLTSRTETTGVTGKINIADTAYDCLMEPQNADPTFQFDFRGLV 579
Query: 1078 QIKGKGAMHTYWLLGKE 1094
+KGK +LL ++
Sbjct: 580 NMKGKPKPCPCYLLSRK 596
>UniRef50_Q9XZS0 Cluster: Guanylyl cyclase; n=4; cellular
organisms|Rep: Guanylyl cyclase - Dictyostelium
discoideum (Slime mold)
Length = 1486
Score = 158 bits (384), Expect = 8e-37
Identities = 92/243 (37%), Positives = 143/243 (58%), Gaps = 12/243 (4%)
Query: 850 INIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP 909
INI+ S FE L N + + LD ++++TE L+ +LP + + + G ++
Sbjct: 1111 INIITSYFEELFNRLNWVHGRL------LDKDQRETESLVAEILPADIVKSMKSGRQLIV 1164
Query: 910 EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMV 969
+EF+ V+I+ SDIVGFT +AAR + Q+V+ LN +Y+TFD +++ V K+ TIGDAY
Sbjct: 1165 DEFKNVTIFLSDIVGFTEMAARMSPRQLVETLNQIYSTFDEIAQEFGVLKIATIGDAYFC 1224
Query: 970 VGGLPQRTR-DHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTM 1028
V G P + + DHA VA MA+ +L +R + + P+ +RIG+HTGP AGVVG+ M
Sbjct: 1225 VSGCPDKDQTDHAFRVANMAIKMLESIK--SIRTVDNIPIRMRIGIHTGPVIAGVVGIKM 1282
Query: 1029 PRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
Y L+G++V +MEST A I +S T L + ++ R G+ + K + TY
Sbjct: 1283 IHYQLWGESVQITQQMESTSRADMIHVSEDTFNILKSKYLFEERPDGIIK---KRKIKTY 1339
Query: 1089 WLL 1091
+LL
Sbjct: 1340 FLL 1342
Score = 145 bits (352), Expect = 6e-33
Identities = 75/188 (39%), Positives = 114/188 (60%), Gaps = 9/188 (4%)
Query: 910 EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMV 969
+ ++ V++ F +IV F AL + ++ QV++LLN++Y +FD + Y V KVE IG+ YMV
Sbjct: 389 DSYDPVTVLFCEIVNFNALVEKMSSTQVINLLNEVYNSFDRLTDVYGVTKVEHIGNVYMV 448
Query: 970 VGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMP 1029
VGG P+ DHA+ VA M+L +L + RF + + +RIG+HTGP G++G
Sbjct: 449 VGGCPELCPDHAQRVAHMSLGMLSVIRRFGI-------VQVRIGMHTGPVVGGIIGKKKL 501
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYW 1089
+ LFGDT+NT+SRM S + RIQ+S + L + RG Q+KGKG M T++
Sbjct: 502 SWHLFGDTINTSSRMASHSSIGRIQVSHPVQQ--LLRPYFLFEDRGKIQVKGKGLMRTFY 559
Query: 1090 LLGKEGFD 1097
L+ + D
Sbjct: 560 LVKTKQLD 567
>UniRef50_Q5UFR4 Cluster: Cya1625; n=1; Mycobacterium smegmatis|Rep:
Cya1625 - Mycobacterium smegmatis
Length = 369
Score = 158 bits (383), Expect = 1e-36
Identities = 93/248 (37%), Positives = 143/248 (57%), Gaps = 6/248 (2%)
Query: 847 GRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR 906
G I+ V + ++ + L E+ R + ++ E +++E+LL +LP ++A RL +R
Sbjct: 103 GFVISTVSAAVMVVATVWSALREIARAE-DAMEAEYQRSEKLLANILPATIATRLKDPAR 161
Query: 907 -VEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGD 965
+ + +++ SI F+DI G+T A+ + +V L+ LYT DA +EQ+ + KV+T GD
Sbjct: 162 TIIADRYDDASILFADIAGYTKRASETAPCDLVRFLDTLYTDLDALVEQHCLEKVKTSGD 221
Query: 966 AYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVG 1025
+YMVVGG+P+ DHAE++A +AL + P LRIGL GP AGVVG
Sbjct: 222 SYMVVGGIPEPRTDHAEALAALALDMAAAVADLTDPEGRRVP--LRIGLAAGPVVAGVVG 279
Query: 1026 LTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAM 1085
Y ++GD VN ASRMEST RIQ+ +L A + L RG ++KGKG M
Sbjct: 280 ARRFFYDVWGDAVNVASRMESTDVEGRIQVPDDMCLRLRHA--FVLEERGEVEVKGKGVM 337
Query: 1086 HTYWLLGK 1093
T++L+G+
Sbjct: 338 RTWYLVGR 345
>UniRef50_Q4T0M0 Cluster: Guanylate cyclase; n=1; Tetraodon
nigroviridis|Rep: Guanylate cyclase - Tetraodon
nigroviridis (Green puffer)
Length = 1001
Score = 154 bits (374), Expect = 1e-35
Identities = 77/172 (44%), Positives = 109/172 (63%), Gaps = 1/172 (0%)
Query: 790 EEIIDKLCR-PPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQRGR 848
++II K+ P RP+ E +M CW+E P RPDF + ++ +
Sbjct: 655 QKIIQKVRNGQKPFFRPTTDNRCHSEELTILMEGCWAEDPAERPDFGHIKIYVAKLNKEG 714
Query: 849 KINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVE 908
+I++++ +E+Y+NNLE L+ ERT+ EK+K E LL ++LP SVAE+L G V+
Sbjct: 715 STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQ 774
Query: 909 PEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKV 960
E F+ V+IYFSDIVGFTA++A ST +QVV LLNDLYT FDA I+ + VYKV
Sbjct: 775 AEAFDSVTIYFSDIVGFTAMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKV 826
Score = 148 bits (359), Expect = 8e-34
Identities = 74/125 (59%), Positives = 89/125 (71%), Gaps = 1/125 (0%)
Query: 959 KVETIGDAYMVVGGLPQRT-RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTG 1017
+VETIGDAYMVV GLP R + HA +A M+L LL F++RH P+ L LRIG+HTG
Sbjct: 877 QVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTG 936
Query: 1018 PCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLT 1077
P CAGVVGL MPRYCLFGDTVNTASRMES G A +I +SS T E L G + L+ RG
Sbjct: 937 PVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFGYFDLQLRGDV 996
Query: 1078 QIKGK 1082
++K +
Sbjct: 997 EMKAR 1001
Score = 52.0 bits (119), Expect = 1e-04
Identities = 25/61 (40%), Positives = 40/61 (65%), Gaps = 1/61 (1%)
Query: 626 LLMQNLRQENVNPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLV 684
L M++++ ++ FIG C+ +V + C RGSL+D+L + I LDW FR SL++D+V
Sbjct: 560 LQMRDIQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIV 619
Query: 685 K 685
K
Sbjct: 620 K 620
>UniRef50_A1ZSW4 Cluster: Atrial natriuretic peptide receptor A; n=1;
Microscilla marina ATCC 23134|Rep: Atrial natriuretic
peptide receptor A - Microscilla marina ATCC 23134
Length = 562
Score = 154 bits (374), Expect = 1e-35
Identities = 81/226 (35%), Positives = 126/226 (55%), Gaps = 4/226 (1%)
Query: 869 ELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTAL 928
E ++ E++++EK K+++LL +LP VAE L + + + ++ ++ F+D GFT +
Sbjct: 309 EQLKLANEEINIEKDKSDKLLLNILPSDVAEELKINGKSQVRNYDMATVMFTDFKGFTKI 368
Query: 929 AARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMA 988
A+ + ++V L+ + FD IE+Y + K++TIGDAYM VGG+P + +A A
Sbjct: 369 ASFTDPAEIVKNLDTCFAAFDQIIEEYNLEKIKTIGDAYMCVGGIPNENKSNAVDATLAA 428
Query: 989 LHLLHLAGRFRVRHL--PDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMES 1046
L + FR L + LR+G++TGP AGV+G Y ++GDTVNTASRMES
Sbjct: 429 LSIRKFMADFRTEKLLRGEQVWELRLGINTGPLIAGVIGTKKFAYDVWGDTVNTASRMES 488
Query: 1047 TGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
G I +S T E L ++ G Q KGKG + Y + G
Sbjct: 489 NGVVNEISVSQVTYE--LVKDFFECEYHGRVQAKGKGEIDMYLVKG 532
>UniRef50_UPI0000E490E0 Cluster: PREDICTED: similar to guanylate
cyclase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to guanylate cyclase -
Strongylocentrotus purpuratus
Length = 591
Score = 154 bits (373), Expect = 2e-35
Identities = 78/169 (46%), Positives = 108/169 (63%), Gaps = 5/169 (2%)
Query: 850 INIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP 909
+N V +M + Y++ L +ERT++L EKK TE LL ++LPR VA ++ +V
Sbjct: 416 LNSVGNMTGWIHDYAHRL----KERTDELKQEKKMTESLLYQLLPRKVANQIRAKQQVRA 471
Query: 910 EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMV 969
E F+ V+I+FSDIVGFT ++A ++VV +LNDLY+ FD I+ Y VYKVETIGDAYMV
Sbjct: 472 ESFDAVTIFFSDIVGFTRISAHINPIEVVSMLNDLYSCFDGRIDVYDVYKVETIGDAYMV 531
Query: 970 VGGLPQRTRD-HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTG 1017
G P+R D H + +ATM++ L + V P L +RIGLHTG
Sbjct: 532 ASGCPERNGDKHVKEIATMSIDLRSAVKQVHVPRSPSIKLQVRIGLHTG 580
>UniRef50_Q394B3 Cluster: Adenylate/guanylate cyclase; n=4;
Burkholderiaceae|Rep: Adenylate/guanylate cyclase -
Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 395
Score = 153 bits (372), Expect = 2e-35
Identities = 95/257 (36%), Positives = 144/257 (56%), Gaps = 18/257 (7%)
Query: 848 RKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLML---- 903
+K+ V++ ++ + S+ L+ L + + E+K +E+LL MLP +AERL +
Sbjct: 144 QKVREVEASHVLIRRQSSELQSLYAK----VVAEQKVSERLLLNMLPYPIAERLKVHLDD 199
Query: 904 --GS--RVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYK 959
GS V + F +VS+ F+DIV FT +A Q+V++LN+++T FD + + K
Sbjct: 200 IAGSFPEVIADRFADVSVLFADIVDFTGFSAGMRPEQLVEMLNEIFTGFDTIADHCGLEK 259
Query: 960 VETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFR-VRHLPDTPLHLRIGLHTGP 1018
++TIGDAYM GLP DHA A MAL ++ RF RH L LRIG+++G
Sbjct: 260 IKTIGDAYMAAAGLPVPAADHATRAAHMALDMIDALARFNAARH---CNLKLRIGINSGE 316
Query: 1019 CCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQ 1078
AGV+G Y L+G VN ASRMES G A R+Q+ T A +++ + RGL
Sbjct: 317 VVAGVIGKRKFIYDLWGAAVNLASRMESQGVAGRVQV--TDATRVMLGEAFVFEERGLIA 374
Query: 1079 IKGKGAMHTYWLLGKEG 1095
KG G T++++G+ G
Sbjct: 375 AKGMGEFRTWFVVGRAG 391
>UniRef50_Q92WJ5 Cluster: Putative regulatory protein; n=2;
Sinorhizobium|Rep: Putative regulatory protein -
Rhizobium meliloti (Sinorhizobium meliloti)
Length = 520
Score = 153 bits (371), Expect = 3e-35
Identities = 84/213 (39%), Positives = 123/213 (57%), Gaps = 5/213 (2%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAV 935
+Q+ EK + + L+ +LP + RL G + + F+EVSI F+DIVGF+ +AA TA
Sbjct: 310 QQIKTEKLRADSLIRAILPDQIVARLQDGEEIIADRFDEVSILFADIVGFSPIAASLTAS 369
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLA 995
+V L+ ++ FD EQ+RV K++TIGDAYM G+P+ DHA+ + + +L
Sbjct: 370 DLVRRLDRMFRRFDLLTEQHRVEKIKTIGDAYMAACGIPEPAPDHADRIVALGKSMLRSL 429
Query: 996 GRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQI 1055
PD +RIG+HTGP AG++G Y ++G+TVN ASR+ES G A IQI
Sbjct: 430 QDMEAG--PDR-FRVRIGIHTGPVVAGLIGRLRFVYDVWGETVNIASRLESQGVADVIQI 486
Query: 1056 SSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
S T L G + L R +++G GA+ TY
Sbjct: 487 SEATRRAL--RGPWTLERRCALELRGIGAVETY 517
>UniRef50_A7RN69 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 769
Score = 153 bits (371), Expect = 3e-35
Identities = 91/234 (38%), Positives = 130/234 (55%), Gaps = 9/234 (3%)
Query: 867 LEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFT 926
L + +R+ L +K+ T+QLL +LP SVA L V+ E E V++ FS IV F
Sbjct: 479 LTDKLRQTHNALAEKKQLTDQLLYSVLPPSVANELRHNRPVQAERAEMVTLLFSGIVDFA 538
Query: 927 ALAARSTAVQVVDLLNDLYTTFDAAIEQY--RVYKVETIGDAYMVVGGLPQRTRDHAESV 984
+ S +++V LLN++YT FD + VYKVET+GD YM V GLP+R HA S+
Sbjct: 539 QICKNSKPMEIVMLLNNIYTKFDMLTDPSINDVYKVETVGDKYMAVSGLPERCAFHARSI 598
Query: 985 ATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRM 1044
MAL + H+ + H D + ++IG+H+G AGVVG PRYCLFG+TVN SR
Sbjct: 599 CNMALDMKHVTQS--IIHKGDK-IQIKIGIHSGEVVAGVVGHKTPRYCLFGNTVNLTSRT 655
Query: 1045 ESTGAAWRIQISSTTAEKLLAA----GGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
E+TGA ++ I+ T LL + RG +KG+ +LL ++
Sbjct: 656 ETTGAPGQVNITEFTYRCLLEPECQDPSFVFERRGPVAMKGRQEPMVTYLLTRD 709
>UniRef50_A7C2F8 Cluster: Rh-like protein/ammonium transporter; n=1;
Beggiatoa sp. PS|Rep: Rh-like protein/ammonium
transporter - Beggiatoa sp. PS
Length = 391
Score = 152 bits (368), Expect = 7e-35
Identities = 95/258 (36%), Positives = 142/258 (55%), Gaps = 13/258 (5%)
Query: 838 HDVFRQM-QRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRS 896
HD F ++ Q G N V +FE LEK ++L+ L ++ E LL + P+
Sbjct: 138 HDPFTEIGQIGFMYNNV--IFE-LEK----TKKLLESEKIALQTANEQAENLLLNIFPKP 190
Query: 897 VAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYR 956
+A+RL G V + F EV++ F+DI GFT ++ + Q+V+ LN ++ D +E+Y
Sbjct: 191 IAQRLKKGETVITDTFAEVTVLFADISGFTNMSTQIPPHQLVETLNLFFSEIDLQVEKYG 250
Query: 957 VYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT 1016
+ K++TIGD YM V G+P +HA +A +AL + +A + + PL +RIGLH+
Sbjct: 251 IEKIKTIGDCYMAVAGIPFPCSNHAVRIAEIALDIHEMAKNY---EMLGKPLQMRIGLHS 307
Query: 1017 GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGL 1076
GP AGV+G Y L+GDTVNTASRMES G Q++ T +L Y +R
Sbjct: 308 GPVIAGVIGKRKFIYDLWGDTVNTASRMESHGIPGETQVTEGTYLRLKT--DYIFETRPP 365
Query: 1077 TQIKGKGAMHTYWLLGKE 1094
+KGKG M Y L ++
Sbjct: 366 IMVKGKGEMPVYLLKARK 383
>UniRef50_Q47AI8 Cluster: Adenylyl cyclase class-3/4/guanylyl cyclase;
n=1; Dechloromonas aromatica RCB|Rep: Adenylyl cyclase
class-3/4/guanylyl cyclase - Dechloromonas aromatica
(strain RCB)
Length = 431
Score = 151 bits (367), Expect = 9e-35
Identities = 90/223 (40%), Positives = 129/223 (57%), Gaps = 6/223 (2%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAA 930
+ E L E++++E+LL +LP +AERL S+ + F +V++ F DIV FT +A
Sbjct: 201 LEETHRLLQDEQERSERLLLNILPGPIAERLKHDSQAIADGFADVTVMFVDIVNFTRIAE 260
Query: 931 RSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALH 990
T QV +LN ++++FD EQY + K++TIGDAYMV GGL ++ +S+A +A+
Sbjct: 261 GMTPQQVFAMLNRIFSSFDELAEQYGMEKIKTIGDAYMVAGGLNNELNNYTQSIAELAIA 320
Query: 991 LLHLAGR-FRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
+ L R F V D L +RIG+ TGP AGVVG Y L+GDTVN ASR+ S G
Sbjct: 321 MRDLLHRDFTVN---DMHLDVRIGIGTGPVVAGVVGKKKFIYDLWGDTVNLASRITSEGT 377
Query: 1050 AWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
IQ+ +TT +L AG + +KGKG Y L+G
Sbjct: 378 PGMIQLDATTYHRL--AGHFAFDEPQTLHLKGKGNTVVYRLIG 418
>UniRef50_UPI0000DB7371 Cluster: PREDICTED: similar to Guanylyl
cyclase at 89Db CG14886-PA; n=3; Endopterygota|Rep:
PREDICTED: similar to Guanylyl cyclase at 89Db CG14886-PA
- Apis mellifera
Length = 621
Score = 150 bits (364), Expect = 2e-34
Identities = 80/198 (40%), Positives = 121/198 (61%), Gaps = 11/198 (5%)
Query: 853 VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP--E 910
++ MFE E+ S LE LD K K+++LL M+P++VA+RL G+ E
Sbjct: 427 LEMMFERAEQRSTELENSYA----LLDRWKNKSDELLYSMIPQTVADRLRAGASPLSTCE 482
Query: 911 EFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVV 970
FE +S+ F ++ F A+ +V +N +++ FD+ ++++ VYKVET+G YM
Sbjct: 483 SFESISVLFCELCDFDYSTIEG-AMDIVSSMNAVFSCFDSLMDEFNVYKVETVGRIYMAA 541
Query: 971 GGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPD-TPLHLRIGLHTGPCCAGVVGLTMP 1029
G P RT +HA+++A ++L LL R LP + +RIG+H+GP AGVVG+ +P
Sbjct: 542 SGAPDRTENHAQNIADVSLQLLK---HVRSLKLPSGLDIQIRIGIHSGPAVAGVVGIKVP 598
Query: 1030 RYCLFGDTVNTASRMEST 1047
RYC FGDTVNTASRM++T
Sbjct: 599 RYCFFGDTVNTASRMQTT 616
>UniRef50_Q28S34 Cluster: Adenylate/guanylate cyclase; n=1; Jannaschia
sp. CCS1|Rep: Adenylate/guanylate cyclase - Jannaschia
sp. (strain CCS1)
Length = 417
Score = 149 bits (361), Expect = 5e-34
Identities = 87/214 (40%), Positives = 123/214 (57%), Gaps = 5/214 (2%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVE-PEEFEEVSIYFSDIVGFTALAARSTAVQ 936
L++E ++E LL +LPR +A RL + V+I F+DI FT L+AR +
Sbjct: 204 LEVEYARSEDLLYSLLPREIAGRLKAEPHTTIADSLPNVAIVFADIANFTPLSARLDPRR 263
Query: 937 VVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAG 996
VVDLLN ++T FD +++++ K++TIGDAYMV G+P + A A MAL +L +A
Sbjct: 264 VVDLLNGVFTEFDGLADRHQLEKIKTIGDAYMVAAGMPNSCGNPAHRAADMALDMLEVAR 323
Query: 997 RFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
V LP+ +RIGLH GP AGV+G Y ++G+TVNTASRME+ A RI I
Sbjct: 324 ATSVA-LPE-GFEIRIGLHVGPVVAGVIGNRKLFYDVWGETVNTASRMETYSAPGRILI- 380
Query: 1057 STTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
T A + + RG +KG G + T+WL
Sbjct: 381 -TPAARAQLGEDFMFEPRGEIDVKGIGIVETWWL 413
>UniRef50_A7S7B3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 918
Score = 149 bits (360), Expect = 6e-34
Identities = 94/251 (37%), Positives = 144/251 (57%), Gaps = 21/251 (8%)
Query: 858 EMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP--EEFEEV 915
++LEK S LE+ ++ +++ E+ ++ QLL +M+P+ +A+RL G + F+ V
Sbjct: 656 QLLEK-SRELEKNMK----RVERERMRSNQLLYQMIPKQIADRLKEGQDAIDTCQHFDCV 710
Query: 916 SIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKV----------ETIGD 965
+I FS + GF L + +A++VV ++N ++T FD E++ VYK ET+GD
Sbjct: 711 TILFSYLDGFVQLCSHVSAMEVVSVVNTMFTVFDKLSEKHDVYKAFDLHCSILKFETLGD 770
Query: 966 A-YMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVV 1024
A YM V G P HAE +A MAL ++ + + + L + IG+H+G AGVV
Sbjct: 771 AIYMAVSGAPVPKARHAEPMAAMALDMIDAMDEIK-KFCSNALLTITIGMHSGAVVAGVV 829
Query: 1025 GLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKG-KG 1083
G P+YCLFG TVN ASR+ +T RI IS++ E LL + RG +KG +G
Sbjct: 830 GKRTPQYCLFGHTVNIASRLRTTALPMRIHISNSCNECLLNT-EFHTEFRGTILLKGIQG 888
Query: 1084 AMHTYWLLGKE 1094
M TYWL+G+E
Sbjct: 889 EMKTYWLIGRE 899
>UniRef50_Q7WWV9 Cluster: Putative regulatory protein; n=1; Ralstonia
eutropha H16|Rep: Putative regulatory protein - Ralstonia
eutropha (strain ATCC 17699 / H16 / DSM 428 / Stanier
337)(Cupriavidus necator (strain ATCC 17699 / H16 / DSM
428 / Stanier337))
Length = 412
Score = 148 bits (358), Expect = 1e-33
Identities = 91/249 (36%), Positives = 143/249 (57%), Gaps = 16/249 (6%)
Query: 853 VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERL-----MLGSRV 907
+ + +E++ + + L+ L +++ E+K +E+LL +LP +AERL ++ S V
Sbjct: 166 LQASWELIRRQRDELQSLY----DRILAEQKLSERLLLNLLPYPIAERLKARPDLIASGV 221
Query: 908 EP---EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIG 964
+ F EV++ F+DIV FT +A + Q+V +LN+++T FD E + K++TIG
Sbjct: 222 PELIADSFPEVTVLFADIVAFTRFSAGMSPEQLVAILNEIFTEFDTIAEVRGLEKIKTIG 281
Query: 965 DAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVV 1024
DAYM GLP+ DHA A MAL++ F +H L +RIG+++G AGV+
Sbjct: 282 DAYMAAAGLPEPAPDHAVRAAHMALNMSDALMHFN-QH-TGFNLQMRIGINSGAVVAGVI 339
Query: 1025 GLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGA 1084
G Y L+G VN ASRMES G A R+Q+ T A + L ++ RG + KG GA
Sbjct: 340 GKRKFIYDLWGAAVNIASRMESHGVAGRVQV--TDATRRLLGESFQFEERGSIEAKGIGA 397
Query: 1085 MHTYWLLGK 1093
+HT++L G+
Sbjct: 398 LHTWFLTGR 406
>UniRef50_A7RN70 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 629
Score = 147 bits (356), Expect = 2e-33
Identities = 86/229 (37%), Positives = 132/229 (57%), Gaps = 8/229 (3%)
Query: 867 LEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFT 926
L + +++ + +L+ E++ ++LL +LP SVA L L V ++E V+I FS IV FT
Sbjct: 383 LTDKLQQTSRELENEQQLNDRLLYSILPASVANDLRLRKPVNANKYEIVTIMFSGIVDFT 442
Query: 927 ALAAR-STAVQVVDLLNDLYTTFDAAIEQYR-VYKVETIGDAYMVVGGLPQRTRDHAESV 984
+ +++V++LN++YT FD + +YKVET+GD YM V GLP R HA ++
Sbjct: 443 NYCNKIKEPMEIVEMLNEVYTEFDQLTDSNDDIYKVETVGDKYMAVSGLPTRCDKHALNI 502
Query: 985 ATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRM 1044
A +AL ++ ++ + + + L + IG+H+G AGVVG PRYCLFG+TVN SR
Sbjct: 503 ANLALDMIDISKGMKAKGIQ---LQVTIGIHSGEVVAGVVGQKKPRYCLFGNTVNLTSRT 559
Query: 1045 ESTGAAWRIQISSTTAEKLLAA--GGYKLRSRGLTQIKG-KGAMHTYWL 1090
E+TG +I +S LL + + RG +KG K M TY L
Sbjct: 560 ETTGLKGKINVSEYAYRCLLVQPHEQFVFKKRGPVVMKGKKEPMITYIL 608
>UniRef50_A4AWH6 Cluster: Adenylate/guanylate cyclase; n=1;
Flavobacteriales bacterium HTCC2170|Rep:
Adenylate/guanylate cyclase - Flavobacteriales bacterium
HTCC2170
Length = 394
Score = 145 bits (351), Expect = 8e-33
Identities = 80/226 (35%), Positives = 127/226 (56%), Gaps = 4/226 (1%)
Query: 865 NNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVG 924
++L LI + E L E+KK++ LL+ +LP ++ L + P+ +++++ F+D
Sbjct: 172 SSLSVLIDKSEESLMAEQKKSDDLLHNILPANIIRDLKESGKTIPKRHKDITVLFTDFEN 231
Query: 925 FTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESV 984
FT L A +A+ +V+ LND++ FD + + V K+ETIGD+YM GL + +HA +
Sbjct: 232 FTKLVASISAITLVNELNDIFGRFDEIMAETEVEKIETIGDSYMAACGLEKEMANHAANC 291
Query: 985 ATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRM 1044
A +L H + +R+G+H+G AGVVG Y LFGDT+NTASR+
Sbjct: 292 IRAAQMMLSYLEERNKSH--EIKWKMRVGIHSGTVVAGVVGKKKFAYDLFGDTINTASRI 349
Query: 1045 ESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
E G +I ISS+T E++ +K SRG KGKG + Y++
Sbjct: 350 EFAGEVGKINISSSTYEQI--KNDFKCLSRGKIFAKGKGDLEMYFV 393
>UniRef50_A6PTF8 Cluster: Putative adenylate/guanylate cyclase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: Putative
adenylate/guanylate cyclase - Victivallis vadensis ATCC
BAA-548
Length = 281
Score = 144 bits (349), Expect = 1e-32
Identities = 81/220 (36%), Positives = 121/220 (55%), Gaps = 8/220 (3%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARS 932
E E L+ E++++EQLL +LP V L +PE F+ V+++FSDIVGFT ++A
Sbjct: 66 ELKESLEQERERSEQLLRNILPERVIRVLQREGASKPELFDNVTVFFSDIVGFTRMSAEL 125
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLL 992
T V+ L+D++T FD + +++TIGDAY+ V GLP+ +H ++ AL
Sbjct: 126 TPEAVIAELSDIFTQFDHIFTSHGCERIKTIGDAYLAVCGLPEPRPEHCANILRSALE-- 183
Query: 993 HLAGRFRVRHLPDTP--LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
A + R D+P +R G+H+G G+VG Y +FGDTVNTA+RME
Sbjct: 184 --ARAYLERRNQDSPHQWRMRFGIHSGSVVGGIVGTEKYLYDIFGDTVNTAARMEQLSEP 241
Query: 1051 WRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
RI +S T + LA R ++KGKG M ++L
Sbjct: 242 MRINVSETV--RNLAPADCVFTPRPPQEVKGKGEMKMFFL 279
>UniRef50_A1ZW48 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 544
Score = 142 bits (344), Expect = 5e-32
Identities = 79/226 (34%), Positives = 123/226 (54%), Gaps = 4/226 (1%)
Query: 867 LEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFT 926
+ ++I + ++ K+++E LL +LPR VAE L + ++E VS+ F+D GFT
Sbjct: 287 VNQIISRQQAEIVEAKERSETLLLNILPREVAEELKESGKASIRQYEMVSVLFTDFKGFT 346
Query: 927 ALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVAT 986
++A + T V +V L + FD IE+Y + K++TIGDAYM GG+P + + V
Sbjct: 347 SIAEKITPVALVRELETCFLRFDEIIEKYNIEKIKTIGDAYMAAGGIPIANQTNPLDVIL 406
Query: 987 MALHLLHLAGRFR-VRHLPDTPL-HLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRM 1044
L + + + P LR+G++TG AGV+G Y ++GDTVNTASRM
Sbjct: 407 AGLEMQRYMNELKAAKQAAGEPYWELRLGINTGKLIAGVIGKKKFAYDVWGDTVNTASRM 466
Query: 1045 ESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
ES+G ++ IS T E L ++ RG KGKG + Y++
Sbjct: 467 ESSGEVGKVNISGKTYE--LVKDFFECEHRGKVTAKGKGEIDMYFV 510
>UniRef50_Q98GN7 Cluster: Cyclase; n=1; Mesorhizobium loti|Rep:
Cyclase - Rhizobium loti (Mesorhizobium loti)
Length = 356
Score = 141 bits (341), Expect = 1e-31
Identities = 87/249 (34%), Positives = 130/249 (52%), Gaps = 6/249 (2%)
Query: 842 RQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERL 901
R Q+ ++ ++ L + ++ E +RE E L E ++ E LL +LP S+AERL
Sbjct: 112 RLQQKAYEMTLLQERERQLNEKLQSMNEALRESQEGLQREYQRAETLLLNILPASIAERL 171
Query: 902 MLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVE 961
++ + EVS+ F+DIVGFT A AV + +LN + D EQY K++
Sbjct: 172 KADEQIA-DNHAEVSVLFADIVGFTERARSVGAVTTLAILNYFFKAADRLSEQYGCEKIK 230
Query: 962 TIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCA 1021
TIGD MVV GLP DHAE++A AL L R L LRIG+H+GP A
Sbjct: 231 TIGDCVMVVAGLPAARPDHAEALARYALELREAVQHER---FAGERLRLRIGIHSGPIVA 287
Query: 1022 GVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKG 1081
GV+G Y L+G+TVN A+R++++ I+IS T + L + T+++G
Sbjct: 288 GVIGKRRFAYDLWGETVNLAARIQTSAEPDEIRISDAT--RRLLGPDFACDPLAETELRG 345
Query: 1082 KGAMHTYWL 1090
G + + L
Sbjct: 346 TGRVRMWRL 354
>UniRef50_Q73RD3 Cluster: Adenylate/guanylate cyclase catalytic domain
protein; n=1; Treponema denticola|Rep:
Adenylate/guanylate cyclase catalytic domain protein -
Treponema denticola
Length = 1075
Score = 140 bits (340), Expect = 2e-31
Identities = 77/238 (32%), Positives = 133/238 (55%), Gaps = 5/238 (2%)
Query: 853 VDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF 912
V F L+ + L++ ++E+T++L EK+K+++LL LP S+ + L+ +P+ +
Sbjct: 781 VQLRFRALQHRAQELDKKVKEKTKELADEKEKSDKLLKNTLPLSIIDELIKMGESKPKLY 840
Query: 913 EEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGG 972
V++ F+D+VGFT + +T V+ LN L+T FD ++ Y +++T+GD Y+ G
Sbjct: 841 PAVTVLFADVVGFTEWSGHNTPDAVISGLNSLFTHFDGIMDLYGCERIKTLGDGYLACSG 900
Query: 973 LPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYC 1032
L ++HAE V A+ +L F + D+ ++IG+ +G G+VG+ +
Sbjct: 901 LTNE-KNHAERVVDAAVAMLRSLETFNKEN--DSCFSIKIGISSGAITGGIVGVHKYIFD 957
Query: 1033 LFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
+FGDTVNTA R+ES + +S +TA L G Y L R +KGKG + Y++
Sbjct: 958 VFGDTVNTAFRLESVTSPTACTVSESTA--ALIRGKYGLHKRPDQNLKGKGLIPCYYV 1013
>UniRef50_Q0LMK3 Cluster: Adenylyl cyclase class-3/4/guanylyl cyclase;
n=1; Herpetosiphon aurantiacus ATCC 23779|Rep: Adenylyl
cyclase class-3/4/guanylyl cyclase - Herpetosiphon
aurantiacus ATCC 23779
Length = 355
Score = 140 bits (340), Expect = 2e-31
Identities = 83/215 (38%), Positives = 122/215 (56%), Gaps = 2/215 (0%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAV 935
+ + +E+ ++ +LL +LP+++A++L E F VS+ F+DIVGFT L+ A
Sbjct: 137 QAIALEQAQSNRLLRNILPQTIADQLKDQQANIAEYFSSVSVLFADIVGFTELSGHINAK 196
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLA 995
++V LN L++ FD + K++TIGDAYMV GLP DHAE +A A + LA
Sbjct: 197 ELVAWLNRLFSRFDQMTLDVGLEKIKTIGDAYMVAAGLPIAQPDHAERLALFATSM--LA 254
Query: 996 GRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQI 1055
++ PL +RIG+H+GP AGV+G Y L+GDTVN ASRMES+ IQ+
Sbjct: 255 EIEQITMPNGKPLQMRIGIHSGPVVAGVIGTIKFSYDLWGDTVNIASRMESSAHPNTIQV 314
Query: 1056 SSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
S+ T L + L+ R ++K G TY L
Sbjct: 315 SAETYALLQDHEHFSLQPRHGVEMKHLGTRTTYIL 349
>UniRef50_A1ZXW2 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 362
Score = 140 bits (340), Expect = 2e-31
Identities = 81/238 (34%), Positives = 130/238 (54%), Gaps = 5/238 (2%)
Query: 858 EMLEKYSNNLEELIRERTE-QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVS 916
+ + K + E L R R+ QL K++E+LL +LP+ +AE L V P+ +E +
Sbjct: 103 DYVRKPIDKTELLARVRSAIQLSHAYKQSEELLLNILPKEIAEELKAKGTVAPKPYELAT 162
Query: 917 IYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQR 976
+ F+D GFT++AAR + ++ LN + FD IE++ + +++TIGDAYM VGG+P
Sbjct: 163 VLFTDFKGFTSVAARMKPIDLLKELNACFDAFDEIIEKHEMERIKTIGDAYMCVGGVPNA 222
Query: 977 TRDHAESVATMALHLLHLAGRFRVRHLP--DTPLHLRIGLHTGPCCAGVVGLTMPRYCLF 1034
+ + AL + + R + R+G+++G AGV+G Y ++
Sbjct: 223 NTTNPVNAVLAALEMQRFMKQKREEKASQGENYWQCRLGINSGEVIAGVIGRKKFAYDIW 282
Query: 1035 GDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
GDTVN+ASRMES G A ++ IS +T L ++ RG KGKG + Y++LG
Sbjct: 283 GDTVNSASRMESNGEAGKVNISGST--HALVKDLFECEHRGKINAKGKGEVDMYFVLG 338
>UniRef50_A1ZQH6 Cluster: Heat-stable enterotoxin receptor; n=1;
Microscilla marina ATCC 23134|Rep: Heat-stable
enterotoxin receptor - Microscilla marina ATCC 23134
Length = 711
Score = 140 bits (339), Expect = 2e-31
Identities = 83/246 (33%), Positives = 131/246 (53%), Gaps = 8/246 (3%)
Query: 849 KINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVE 908
+I+ + M E+ + E I+++ ++ EK K+++LL +LP A L
Sbjct: 466 QISRQNKMVELSNYELSEKNEFIQQQNTLIEKEKAKSDELLLNILPEQTATELKEKGYAT 525
Query: 909 PEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYM 968
P+ ++ VS+ F+D GFT LA + T +V++ LN +T FD +E++ + K++TIGDAYM
Sbjct: 526 PQHYDLVSVLFTDFKGFTKLAEKITPQEVIEELNYCFTAFDKILEKHNLEKIKTIGDAYM 585
Query: 969 VVGGLPQRTR----DHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVV 1024
GG+P + D ++ M ++H + LP LR+G+HTG AGVV
Sbjct: 586 AAGGIPLANQTNPVDAVKAGLEMQAFMVHWKKDKEAQGLP--VWELRLGIHTGEIIAGVV 643
Query: 1025 GLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGA 1084
G Y ++GDTVN ASRMES G A ++ IS T L ++ RG K KG
Sbjct: 644 GKKKFAYDIWGDTVNLASRMESGGEAGKVNISGDT--YALIKDHFQCEYRGKINAKNKGN 701
Query: 1085 MHTYWL 1090
+ Y++
Sbjct: 702 VDMYFV 707
>UniRef50_A6FX69 Cluster: Adenylate or guanylate cyclase; n=1;
Plesiocystis pacifica SIR-1|Rep: Adenylate or guanylate
cyclase - Plesiocystis pacifica SIR-1
Length = 601
Score = 138 bits (335), Expect = 7e-31
Identities = 76/214 (35%), Positives = 121/214 (56%), Gaps = 6/214 (2%)
Query: 881 EKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDL 940
E + TE+LL ++P S+ L L RV+P+ E+ ++ F+D+VGFT ++ +V
Sbjct: 363 EAEVTERLLLDVMPASIVRELKLHQRVDPKHHEDATVVFADLVGFTRISTTLEPRSLVAE 422
Query: 941 LNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRV 1000
L+ L+ FD ++++ K++TIGDAYM V GLP HA + ALHL +
Sbjct: 423 LDRLFRAFDDVAARWQLEKLKTIGDAYMAVAGLPDPHPRHALAATLAALHLREAVRAYAA 482
Query: 1001 RHLPD----TPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
D P +R+GLH+GP AG++G Y ++G+TVNTA+RMES+ AA RI +S
Sbjct: 483 SPAADGQIKPPWSVRVGLHSGPLIAGIIGRAKLAYDVWGETVNTAARMESSSAADRINVS 542
Query: 1057 STTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
+ T ++ A + RG + KG G + +++
Sbjct: 543 APTHAQI--AAYFVTTPRGPVEAKGLGPVDMFFV 574
>UniRef50_Q8F1T7 Cluster: Adenylate cyclase; n=2; Leptospira
interrogans|Rep: Adenylate cyclase - Leptospira
interrogans
Length = 418
Score = 138 bits (334), Expect = 9e-31
Identities = 78/239 (32%), Positives = 131/239 (54%), Gaps = 7/239 (2%)
Query: 856 MFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEV 915
+FE + Y N+ E+ +R + + ++++LL+ +LP S+A L +RV P
Sbjct: 166 IFEQSKDYQENVNEIFEKRLQDA---RDESDRLLHNILPVSIAAELKKNNRVSPVYINSA 222
Query: 916 SIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ 975
++ F+D GFT ++ + +++ L++ ++ FD + + K++TIGD++M VGG+P+
Sbjct: 223 TVLFTDFKGFTQISESMSPEELISNLDECFSLFDQICADHGLEKIKTIGDSFMCVGGVPE 282
Query: 976 RTRDHAESVATMALHLLHLAGRFRVRHLPD--TPLHLRIGLHTGPCCAGVVGLTMPRYCL 1033
R H VA AL + + + + + +RIG HTGP AGV+G Y +
Sbjct: 283 VNRTHVFDVALAALKMCDAIQKLKEEKNKNGISYWDVRIGFHTGPVAAGVIGKNKFSYDI 342
Query: 1034 FGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
+GDTVN ASRMES+G +I +S + KLL+ + SRG K KG + Y+L G
Sbjct: 343 WGDTVNIASRMESSGEPGKINVSE-ESYKLLSP-FFTFTSRGKIAAKNKGEISMYFLEG 399
>UniRef50_A1ZVN3 Cluster: Adenylate or guanylate cyclase; n=1;
Microscilla marina ATCC 23134|Rep: Adenylate or guanylate
cyclase - Microscilla marina ATCC 23134
Length = 774
Score = 138 bits (333), Expect = 1e-30
Identities = 81/256 (31%), Positives = 139/256 (54%), Gaps = 10/256 (3%)
Query: 837 LHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRS 896
LHD +++ ++ +V + E+ + EE+ +R + +++EK K+++LL +LP +
Sbjct: 523 LHDANNEIKEQQEEILVQN-----EELHHRNEEIEAQR-DAIEVEKNKSDRLLLNILPYA 576
Query: 897 VAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYR 956
A+ L P+ + +VS+ F+D GFT LA + T +V+ LN ++ FD ++Y
Sbjct: 577 TAQELKEKGNATPQHYPKVSVLFTDFKGFTKLAEKLTPTEVIAELNYCFSAFDDICQKYN 636
Query: 957 VYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRV-RHLPDTPL-HLRIGL 1014
+ K++TIGDAYM GG+P + L + +++ + P+ LR+G+
Sbjct: 637 IEKIKTIGDAYMAAGGIPVANDTNPIDTIKAGLEMQTFMAQWKTNKEAQGLPVWELRLGI 696
Query: 1015 HTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSR 1074
HTG AGVVG Y ++GDTVN A+RMES+GA + IS T + L ++ R
Sbjct: 697 HTGEVVAGVVGKNKFAYDVWGDTVNLAARMESSGAPGMVNISGHTYQ--LIKDQFETTYR 754
Query: 1075 GLTQIKGKGAMHTYWL 1090
G + K KG + Y++
Sbjct: 755 GKIKAKNKGEVDMYFV 770
>UniRef50_Q15T90 Cluster: Adenylate/guanylate cyclase; n=1;
Pseudoalteromonas atlantica T6c|Rep: Adenylate/guanylate
cyclase - Pseudoalteromonas atlantica (strain T6c /
BAA-1087)
Length = 407
Score = 136 bits (328), Expect = 5e-30
Identities = 81/221 (36%), Positives = 123/221 (55%), Gaps = 5/221 (2%)
Query: 874 RTEQ-LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARS 932
RT+Q L M +++E LL +LPR +A+RL +++++VSI F D+ F+ L
Sbjct: 189 RTQQKLFMANQRSEALLLNILPRPIAQRLKTVQGKIADQYDQVSICFLDLENFSLLVKTL 248
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLL 992
A +VDLL+D+++ FD E + + K++TIGD YM G+P HA AL +
Sbjct: 249 KAQALVDLLDDVFSQFDRLSEHHGLEKIKTIGDGYMAAAGVPDINNAHAVQCCAYALAVK 308
Query: 993 HLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWR 1052
++H LRIG+ +G AGV+G + Y L+G+ V A+RMES G +
Sbjct: 309 DAFS--ALQHKYHLTTGLRIGIGSGEVVAGVIGRSKFCYDLWGEAVTLAARMESHGRTDQ 366
Query: 1053 IQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
IQ++ +T E +A Y RG +IKG G + TYWLLG+
Sbjct: 367 IQVTQSTYE--MAKHKYCFEPRGEVKIKGLGQIKTYWLLGE 405
>UniRef50_A3I1K5 Cluster: Adenylate/guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate/guanylate cyclase -
Algoriphagus sp. PR1
Length = 420
Score = 136 bits (328), Expect = 5e-30
Identities = 79/243 (32%), Positives = 134/243 (55%), Gaps = 7/243 (2%)
Query: 852 IVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE 911
++ + FE L++ + LE L+ ++ E L+ E++++E LL + P +AE L R +
Sbjct: 180 LIANTFEKLKQQA--LESLVAKQKE-LEFEQERSENLLLNIFPADIAEELKSTGRTQARL 236
Query: 912 FEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVG 971
+ V++ F+D+ FT ++ Q+V LL+ + DA I+++ + K++TIGDAY+
Sbjct: 237 HDNVTVLFADVKNFTIVSEGLLPDQLVALLDTYFQRIDAIIQKHGLEKIKTIGDAYLAAA 296
Query: 972 GLPQRTRDHAESVATMALHLLHLAGRFRV-RHLPDTP-LHLRIGLHTGPCCAGVVGLTMP 1029
G+P+ + A V AL + ++V R P RIG++TG AGVVG
Sbjct: 297 GVPKGNKATARDVVAAALEIQKTNDAYKVLRETEGLPFFDFRIGINTGTVVAGVVGDKKY 356
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYW 1089
Y ++GD VNTA+R+E A R+ IS+ T + + ++L RGL K KG + +W
Sbjct: 357 VYDIWGDAVNTAARIEENSAPGRVNISAFTHQ--VVKEHFELEERGLISAKNKGKIEMFW 414
Query: 1090 LLG 1092
+LG
Sbjct: 415 VLG 417
>UniRef50_A1ZJP1 Cluster: Adenylate cyclase; n=1; Microscilla marina
ATCC 23134|Rep: Adenylate cyclase - Microscilla marina
ATCC 23134
Length = 642
Score = 134 bits (323), Expect = 2e-29
Identities = 79/228 (34%), Positives = 118/228 (51%), Gaps = 4/228 (1%)
Query: 865 NNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVG 924
N ELI + E + E++ ++ LL +LP VA L + + E VS+ F+D G
Sbjct: 378 NTQMELIETQNETIKQEQQISDALLLNILPEQVANELKEHGKAKIRHHEMVSVLFTDFKG 437
Query: 925 FTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESV 984
FT LA ++V L +T FD +E++ + K++TIGDAYM VGGLP + +
Sbjct: 438 FTKLAETMPPQELVQELEKCFTLFDEIMEKHNLEKIKTIGDAYMAVGGLPVPNTTNFVDI 497
Query: 985 ATMALHLLHLAGRFRV-RHLPDTPL-HLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTAS 1042
L + + + + P R+G++TG AGV+G Y ++GDTVNTAS
Sbjct: 498 VLAGLEIQRSMDQLKAEKEAKGEPFWETRLGINTGKLIAGVIGKNKFAYDVWGDTVNTAS 557
Query: 1043 RMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
RMES+G R+ IS T E L ++ RG K KGA+ Y++
Sbjct: 558 RMESSGEIGRVNISGVTYE--LVKDFFECEYRGKIMAKNKGAIDMYFV 603
>UniRef50_Q6DNF3 Cluster: Soluble guanylate cyclase gcy-37; n=2;
Caenorhabditis|Rep: Soluble guanylate cyclase gcy-37 -
Caenorhabditis elegans
Length = 708
Score = 132 bits (320), Expect = 4e-29
Identities = 68/221 (30%), Positives = 126/221 (57%), Gaps = 4/221 (1%)
Query: 837 LHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRS 896
+HD R + + I E+ +K ++++ ++ TE+L+++K +T++LL +P
Sbjct: 358 MHDATRDLVMLNQSRICQ--MELNKKLEETMKKM-KKMTEELEVKKSQTDRLLFEFVPPV 414
Query: 897 VAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYR 956
+AE L V +EF + S+ F+DI F ++ + +++ ++ DL+ FD IE+++
Sbjct: 415 IAEALRAAKTVPAQEFSDCSVIFTDIPDFFTISVNCSPTEIITVVTDLFHRFDRIIEKHK 474
Query: 957 VYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT 1016
YKV ++ D+Y++VGG+P + H E +AL LL A + V L + + LRIG+H
Sbjct: 475 GYKVLSLMDSYLIVGGVPNANQYHCEDSLNLALGLLFEAKQVVVPKL-ERSVRLRIGVHC 533
Query: 1017 GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISS 1057
GP AG+V PR+C+ G+TVN + S + ++ +S+
Sbjct: 534 GPVVAGIVSQQKPRFCVLGNTVNVTKSICSHSSPGKVLVSN 574
>UniRef50_Q8F778 Cluster: Adenylate cyclase; n=3; Leptospira
interrogans|Rep: Adenylate cyclase - Leptospira
interrogans
Length = 366
Score = 132 bits (318), Expect = 8e-29
Identities = 79/218 (36%), Positives = 119/218 (54%), Gaps = 8/218 (3%)
Query: 875 TEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTA 934
T L++E+KK++ LL +LP SVAE L V P +E V++ F+D+ GFT +A +
Sbjct: 117 TRNLNIERKKSDSLLLNILPESVAEELKRNDFVVPIRYENVTVLFTDMAGFTKIAESMSP 176
Query: 935 VQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALH---L 991
+++ L+ + FD +++ + K++TIGD+YM GGLP H+ L
Sbjct: 177 EELLSELDLFFREFDLITKKHGMEKIKTIGDSYMAAGGLPIVNNTHSIDAVLCGLEFQKF 236
Query: 992 LHLAGRFRV-RHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
+ L + R HLP LR+G+H+G AGVVG Y ++GD+VNTASRMES+G
Sbjct: 237 MRLKKKERENNHLPF--WELRLGIHSGSVVAGVVGTKKFAYDIWGDSVNTASRMESSGIP 294
Query: 1051 WRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
+ IS T EK+ + RG + K KG + Y
Sbjct: 295 GEVNISQETFEKI--KDFFICDYRGKIKAKNKGEIDMY 330
>UniRef50_A1ZFP4 Cluster: Two-component hybrid sensor and regulator;
n=1; Microscilla marina ATCC 23134|Rep: Two-component
hybrid sensor and regulator - Microscilla marina ATCC
23134
Length = 1269
Score = 131 bits (316), Expect = 1e-28
Identities = 80/235 (34%), Positives = 128/235 (54%), Gaps = 11/235 (4%)
Query: 858 EMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSI 917
E L++Y+ LE+ I ERTE+++ LL +LP VA L + + + ++
Sbjct: 1018 EKLQEYNATLEQKIEERTEEINT-------LLLNILPEEVANDLKTNGKAPVKYYAMSTV 1070
Query: 918 YFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ-R 976
F+D GFT A+ + ++V+ LN+ + FD +EQY + K++TIGDAYM GG+PQ
Sbjct: 1071 LFTDFQGFTKQASEMDSKELVEDLNEYFAGFDDIMEQYNLEKIKTIGDAYMAAGGIPQSN 1130
Query: 977 TRDHAESV-ATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
T + ++V A +A+ A R + +R+G++TG AGV+G Y ++G
Sbjct: 1131 TTNPVDAVLAGLAIQQFVAAKRAERKAEGKQFWDVRLGVNTGEVIAGVIGTKKFAYDVWG 1190
Query: 1036 DTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
D+VNTA+RMES G + IS T E + + + RG KGKG + Y++
Sbjct: 1191 DSVNTAARMESGGKVGEVNISHNTYE--MVKDYFDVEHRGKVNAKGKGEVDMYFV 1243
>UniRef50_A7RRQ7 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 1052
Score = 128 bits (310), Expect = 7e-28
Identities = 87/244 (35%), Positives = 133/244 (54%), Gaps = 27/244 (11%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE------FEEVSIYFSDIVGF- 925
E ++++ ++ ++LL +LP VA+ LG + E ++V++ FS+I F
Sbjct: 808 EEKKEMEQLREYNKKLLYNILPVHVAQHF-LGHKANKNEDLYYQSCDKVAVMFSNICNFS 866
Query: 926 ---TALAARSTAVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTRD 979
T L A V+ + LLN++ FD + + + + K++TIG+ YM G+ ++
Sbjct: 867 DFYTELDANGEGVECLRLLNEILADFDELLSEPQFQCIEKIKTIGETYMAASGIKPESQ- 925
Query: 980 HAESVATMALHLLHLA--GRFRVRHLPDTPLH------LRIGLHTGPCCAGVVGLTMPRY 1031
E +AT+ H+ +A R L D LH ++IGL+ GP AGV+G P+Y
Sbjct: 926 --EKLATLN-HICTMADFAMAMKRKLEDINLHSFNNFAMKIGLNFGPVVAGVIGAHKPQY 982
Query: 1032 CLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLL 1091
++GDTVN ASRM STG IQ++ E +L+ GY RGL +KGKG M TYWLL
Sbjct: 983 DIWGDTVNVASRMYSTGKDNHIQVTKAMYE-ILSTRGYTFDCRGLVAVKGKGKMVTYWLL 1041
Query: 1092 GKEG 1095
GKEG
Sbjct: 1042 GKEG 1045
Score = 102 bits (244), Expect = 7e-20
Identities = 66/197 (33%), Positives = 101/197 (51%), Gaps = 13/197 (6%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLM--LGSRVEP---------EEFEEVSIYFSDIVGFT 926
+ E + E+LL +LPR VA + + S + + E VSI F+DI GFT
Sbjct: 296 IQKENQNQERLLLSVLPRYVAMEMKDDIESGISQNSQFHKIYIQRHENVSILFADIEGFT 355
Query: 927 ALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVAT 986
L+++ TA ++ LN+LY FD + +++ +GD Y V GLP DHA S
Sbjct: 356 VLSSQCTAQSLIKTLNELYARFDQLAVENHCLRIKILGDCYYCVSGLPDPRPDHAHSCIE 415
Query: 987 MALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMES 1046
M L ++ A F VR L++R+G+H G +GV+GL +Y ++ D V A+ MES
Sbjct: 416 MGLAMID-AISF-VRDATQVNLNMRVGVHMGKVHSGVLGLVKWQYDVWSDDVTIANHMES 473
Query: 1047 TGAAWRIQISSTTAEKL 1063
G R+ I+ + L
Sbjct: 474 GGLPGRVHITKEVLDCL 490
>UniRef50_UPI0000F1FEB6 Cluster: PREDICTED: similar to solble guanylyl
cyclase alpha2 subunit, partial; n=1; Danio rerio|Rep:
PREDICTED: similar to solble guanylyl cyclase alpha2
subunit, partial - Danio rerio
Length = 674
Score = 128 bits (308), Expect = 1e-27
Identities = 70/176 (39%), Positives = 106/176 (60%), Gaps = 7/176 (3%)
Query: 860 LEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYF 919
L+K + L+ + + + L+ EK++T LL + P VA+RL G V+ ++F++V++ F
Sbjct: 470 LKKRMDKLKATLEKTHQALEEEKRRTVDLLYSIFPGDVAQRLWQGLPVQAKKFDDVTMLF 529
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD 979
SDIVGFTA+ A+ T +QV+ +LN+LYT FD VYK+ETIGDAY V GGL ++
Sbjct: 530 SDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGILDVYKIETIGDAYCVAGGLHRKIDS 589
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
HA+ +A MAL ++ L+ PD RIG+H+G +G YC+ G
Sbjct: 590 HAKPIALMALKMMELSEEMLT---PDGN-QSRIGIHSGSVLIETIG---DAYCVAG 638
Score = 42.7 bits (96), Expect = 0.061
Identities = 18/36 (50%), Positives = 26/36 (72%)
Query: 960 VETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLA 995
+ETIGDAY V GGL ++ HA+ +A MAL ++ L+
Sbjct: 627 IETIGDAYCVAGGLHRKIDSHAKPIALMALKMMELS 662
>UniRef50_A0LXB4 Cluster: Secreted protein containing
adenylate/guanylate cyclase catalytic domain; n=1;
Gramella forsetii KT0803|Rep: Secreted protein containing
adenylate/guanylate cyclase catalytic domain - Gramella
forsetii (strain KT0803)
Length = 610
Score = 127 bits (306), Expect = 2e-27
Identities = 69/221 (31%), Positives = 115/221 (52%), Gaps = 3/221 (1%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAA 930
I+ + ++ EK ++E LL +LP A L +V ++FE V++ F+D FT +A
Sbjct: 380 IKRTSAIIEKEKNRSELLLLNILPEETARELKKNGKVRAKKFESVTVLFADFKRFTLIAE 439
Query: 931 RSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALH 990
+++ ++ ++ FD +E+Y + K++TIGD+YM GLP +DHA + A
Sbjct: 440 NLPPERLIKTIDYYFSQFDKIMEKYDIEKIKTIGDSYMAASGLPFPNQDHAYKILMAAFE 499
Query: 991 LLHLAGRFRVRHL-PDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
+ + L D +R+GL++GP AGVVG Y ++GDTVN A+RMES
Sbjct: 500 MTQFVKETKENSLYDDANFDVRVGLNSGPVVAGVVGTKKFAYDIWGDTVNIAARMESHSD 559
Query: 1050 AWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
+I IS T + L + RG ++K + Y++
Sbjct: 560 IGKINISENTYD--LIKDKFDCEYRGEVEVKNGRILKMYYV 598
>UniRef50_Q1NWK5 Cluster: Guanylate cyclase; n=2; delta
proteobacterium MLMS-1|Rep: Guanylate cyclase - delta
proteobacterium MLMS-1
Length = 323
Score = 126 bits (305), Expect = 3e-27
Identities = 74/212 (34%), Positives = 111/212 (52%), Gaps = 6/212 (2%)
Query: 882 KKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLL 941
+K+ + LL LP VAE + P +++ +I FSD+ GFT LA ++V++V ++
Sbjct: 103 EKQVDNLLKNTLPPMVAEEIRYLGSFAPRQYD-CTILFSDVAGFTRLAEELSSVELVAII 161
Query: 942 NDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHL---LHLAGRF 998
+D++ FD + + K++TIGDAYMVV G P DH AL + L + R
Sbjct: 162 DDIFRIFDRVVRDFNGTKIKTIGDAYMVVFGAPVADEDHPVRAVRAALAMQEGLAVFNRQ 221
Query: 999 RVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISST 1058
R RIG+H+GP AGVVG ++ +FGD VN A+R E+ G R+ IS+
Sbjct: 222 RFGAATAQYFRCRIGIHSGPVTAGVVGEDRMQFDVFGDHVNIAARFETAGEPGRVNISAA 281
Query: 1059 TAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
T + L RG +K K AM Y++
Sbjct: 282 TRQHL--PPNLVCEDRGEVALKHKKAMRAYFV 311
>UniRef50_A3HVA1 Cluster: Adenylate/guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate/guanylate cyclase -
Algoriphagus sp. PR1
Length = 464
Score = 126 bits (304), Expect = 4e-27
Identities = 78/242 (32%), Positives = 133/242 (54%), Gaps = 12/242 (4%)
Query: 858 EMLEKYSNNLEELIRERT-------EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPE 910
E LE Y+ LE+ + ERT ++L +EKK++E LL +LP AE L + +
Sbjct: 220 EELEAYNQELEKRVAERTKDLRIKNQELTVEKKRSEDLLLNILPEETAEELKKYGFAKAK 279
Query: 911 EFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVV 970
E ++ F+D V FT ++ ++ ++V L+ + FDA +YR+ K++TIGDA+M
Sbjct: 280 LQENATVMFTDFVNFTKFSSSISSEELVSELDHCFRNFDAITTKYRLEKIKTIGDAHMSA 339
Query: 971 GGLPQRTRDHAESV-ATMALH-LLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTM 1028
G+ D A+ + A + + + + + +HL + +R+G++TGP AGVVGL
Sbjct: 340 CGVTGDGGDVADVIRAGIEMRDFVQSYAKEKPKHLQEY-FQIRVGINTGPVVAGVVGLKK 398
Query: 1029 PRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
+ ++GDTVNTA R++S A ++ +S +T LL + +RG K KG + Y
Sbjct: 399 FSFDIWGDTVNTADRIQSGSVAGKVNVSEST--YLLTKDLFDFENRGKISAKNKGMIPMY 456
Query: 1089 WL 1090
++
Sbjct: 457 FV 458
>UniRef50_O95622 Cluster: Adenylate cyclase type 5; n=41;
Deuterostomia|Rep: Adenylate cyclase type 5 - Homo
sapiens (Human)
Length = 1261
Score = 126 bits (304), Expect = 4e-27
Identities = 82/236 (34%), Positives = 131/236 (55%), Gaps = 19/236 (8%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF----EEVSIYFSDIVGFTA- 927
E E+++ + +LL+ +LP+ VA + R E + E V++ F+ I F+
Sbjct: 1024 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF 1083
Query: 928 ---LAARSTAVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTRD-- 979
L A + V+ + LLN++ FD I + R + K++TIG YM GL T D
Sbjct: 1084 YVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV 1143
Query: 980 ---HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGD 1036
H +++A A+ L+ ++ H + ++IGL+ GP AGV+G P+Y ++G+
Sbjct: 1144 GKTHIKALADFAMKLMDQM-KYINEHSFNN-FQMKIGLNIGPVVAGVIGARKPQYDIWGN 1201
Query: 1037 TVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
TVN ASRM+STG RIQ+ +T ++LAA Y+L RG+ ++KGKG M TY+L G
Sbjct: 1202 TVNVASRMDSTGVPDRIQV-TTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1256
Score = 106 bits (254), Expect = 4e-21
Identities = 61/193 (31%), Positives = 105/193 (54%), Gaps = 12/193 (6%)
Query: 881 EKKKTEQLLNRMLPRSVAERL----------MLGSRVEPEEFEEVSIYFSDIVGFTALAA 930
E ++ E+LL +LPR VA + M+ ++ ++ + VSI F+DI GFT+LA+
Sbjct: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
Query: 931 RSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALH 990
+ TA ++V LN+L+ FD + +++ +GD Y V GLP+ DHA M +
Sbjct: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMD 543
Query: 991 LLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
++ VR + +++R+G+H+G GV+GL ++ ++ + V A+ ME+ G A
Sbjct: 544 MIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKA 601
Query: 1051 WRIQISSTTAEKL 1063
RI I+ T L
Sbjct: 602 GRIHITKATLNYL 614
>UniRef50_A5P476 Cluster: Putative adenylate/guanylate cyclase; n=1;
Methylobacterium sp. 4-46|Rep: Putative
adenylate/guanylate cyclase - Methylobacterium sp. 4-46
Length = 422
Score = 125 bits (302), Expect = 7e-27
Identities = 72/215 (33%), Positives = 118/215 (54%), Gaps = 4/215 (1%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQ 936
+L E+ + +++L +LP + +R+ G + + V+I F DIVGFT LA+R++
Sbjct: 209 ELRSERDRIDRILRDILPMQIYDRIKGGENHIADLNDHVTISFCDIVGFTHLASRTSPHD 268
Query: 937 VVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAG 996
V+ LLNDL++ D ++ + K++TIGDAYM G+ A +VA AL
Sbjct: 269 VIRLLNDLFSQLDDIAAKHGIEKIKTIGDAYMAAAGVGDAIHKDAHAVAGFALDARRAVL 328
Query: 997 RFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
RH + +R G+ TG +GV+G+T P + ++G TVN ASR+E+ I +
Sbjct: 329 ETGERH--GAAIQMRFGIATGQVISGVIGVTRPVFDVWGSTVNLASRLETASPPGAITLD 386
Query: 1057 STTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLL 1091
+ TAE L +++R G +KG GA+ T+ L+
Sbjct: 387 ARTAE--LLDRRFRVRPSGCIALKGIGAVATFQLV 419
>UniRef50_Q4RZ92 Cluster: Chromosome 1 SCAF14944, whole genome shotgun
sequence; n=1; Tetraodon nigroviridis|Rep: Chromosome 1
SCAF14944, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 173
Score = 125 bits (301), Expect = 9e-27
Identities = 74/164 (45%), Positives = 99/164 (60%), Gaps = 25/164 (15%)
Query: 912 FEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVG 971
F +V+I FSD+VGFT + + T +QVV +LN +YT FD E++RV+KVETIGDAYMVV
Sbjct: 7 FPDVTILFSDVVGFTRICSHITPMQVVSMLNTMYTLFDTLSEKHRVFKVETIGDAYMVVA 66
Query: 972 GLPQRTRDHAESVATMALHLL----HL------------AGRFRVRHLPDTPLHLRI--- 1012
G P++T+ HA ++ MAL ++ HL G ++ + T L L +
Sbjct: 67 GAPEKTKYHAHNICDMALDMVRSIDHLKDPSNGNNIQIRVGGWKAARVEFTHLCLLLYQH 126
Query: 1013 ------GLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
G+H+G AGVVG MPRY L GDTV+TAS MES G A
Sbjct: 127 SFLLLAGIHSGMVVAGVVGHKMPRYGLHGDTVHTASAMESNGKA 170
>UniRef50_A3HV63 Cluster: Adenylate or guanylate cyclase; n=1;
Algoriphagus sp. PR1|Rep: Adenylate or guanylate cyclase
- Algoriphagus sp. PR1
Length = 638
Score = 124 bits (300), Expect = 1e-26
Identities = 74/250 (29%), Positives = 130/250 (52%), Gaps = 2/250 (0%)
Query: 843 QMQRGRKIN-IVDSMFEMLEKYSNNLE-ELIRERTEQLDMEKKKTEQLLNRMLPRSVAER 900
+++R RKI ++ +F + L + +++ E + EK ++++LL +LP VAE
Sbjct: 381 EVERSRKIIFMISGLFLLALAIGLFLRYQFVKKSREIISKEKDRSDKLLLNILPAEVAEE 440
Query: 901 LMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKV 960
L + ++F++V++ F+D FT A +A ++V LN + TFD + K+
Sbjct: 441 LKTKGSSDAKDFDQVTVIFTDFADFTKKAQHLSAKELVKELNTCFKTFDEITYNLGLEKI 500
Query: 961 ETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCC 1020
+TIGDAYM GGL ++ ++A + + +R G+++GP
Sbjct: 501 KTIGDAYMAAGGLNSKSGVKEVALAAIQMKKFIDERNSDPNISRKIKFDMRCGINSGPVV 560
Query: 1021 AGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIK 1080
AG+VG+ +Y ++GDTVNTA RME++ +I IS T L + RG+ +K
Sbjct: 561 AGIVGIKKFQYDIWGDTVNTAQRMEASCEINQINISENTYSLLKDDPDFTFIERGILPVK 620
Query: 1081 GKGAMHTYWL 1090
GKG M +++
Sbjct: 621 GKGEMKMWYI 630
>UniRef50_Q4RVX9 Cluster: Chromosome 9 SCAF14991, whole genome shotgun
sequence; n=3; Euteleostomi|Rep: Chromosome 9 SCAF14991,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 1208
Score = 123 bits (296), Expect = 4e-26
Identities = 79/232 (34%), Positives = 127/232 (54%), Gaps = 15/232 (6%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF----EEVSIYFSDIVGFTA- 927
E E+++ + +LL+ +LP+ VA + R E + E V++ F+ I F+
Sbjct: 972 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEF 1031
Query: 928 ---LAARSTAVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTRDHA 981
L A + V+ + LLN++ FD I + R + K++TIG YM GL T D
Sbjct: 1032 YVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNDSTYDRE 1091
Query: 982 ESVATMALHLLHLAGRFRVRHLPDTPLH---LRIGLHTGPCCAGVVGLTMPRYCLFGDTV 1038
+AL + R +++++ + + ++IGL+ GP AGV+G P+Y ++G+TV
Sbjct: 1092 GRSHILALADYAMRLREQMKYINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTV 1151
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
N ASRM+STG IQ+ +T +L + GYKL RGL ++KGKG M TY+L
Sbjct: 1152 NVASRMDSTGVPDYIQV-TTDLYHVLDSNGYKLDCRGLVKVKGKGEMTTYFL 1202
Score = 98.3 bits (234), Expect = 1e-18
Identities = 50/148 (33%), Positives = 85/148 (57%), Gaps = 2/148 (1%)
Query: 916 SIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ 975
SI F+DI GFT+LA++ TA ++V LN+L+ FD + +++ +GD Y V GLP+
Sbjct: 385 SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLASENHCLRIKILGDCYYCVSGLPE 444
Query: 976 RTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
DHA M + ++ VR + +++R+G+H+G GV+GL ++ ++
Sbjct: 445 PRADHAHCCVEMGVDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS 502
Query: 1036 DTVNTASRMESTGAAWRIQISSTTAEKL 1063
+ V A++ME+ G A RI I+ T + L
Sbjct: 503 NDVTLANQMEAGGKAGRIHITKATLQYL 530
>UniRef50_Q03101 Cluster: Adenylate cyclase, germination specific;
n=3; Dictyostelium discoideum|Rep: Adenylate cyclase,
germination specific - Dictyostelium discoideum (Slime
mold)
Length = 858
Score = 123 bits (296), Expect = 4e-26
Identities = 72/220 (32%), Positives = 118/220 (53%), Gaps = 10/220 (4%)
Query: 883 KKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLN 942
++ L+N++LP V+ +L G V E ++F DI GFT ++ + QV+ +L
Sbjct: 363 REKNNLINKILPLEVSVKLENGEDVVAERSNNACVFFLDIAGFTRFSSIHSPEQVIQVLI 422
Query: 943 DLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATM---ALHLLHLAGRFR 999
++ + D ++ + K++TIGDAYM G+ + D + M A+ +L +
Sbjct: 423 KIFNSMDLLCAKHGIEKIKTIGDAYMATCGIFPKCDDIRHNTYKMLGFAMDVLEFIPKEM 482
Query: 1000 VRHLPDTPLHLRIGLHTGPCCAGVV-GLTMPRYCLFGDTVNTASRMESTGAAWRIQISST 1058
HL L +R+G+H GP +GV+ G P + ++GDTVN ASRMESTG A +I +S
Sbjct: 483 SFHL---GLQVRVGIHCGPVISGVISGYAKPHFDVWGDTVNVASRMESTGIAGQIHVSDR 539
Query: 1059 TAEKLLAAGGYKLRSR-GLTQIKGKGAMHTYWLLGKEGFD 1097
+ L + R + +KGKG M T++L+GK+ D
Sbjct: 540 VYQ--LGKEDFNFSERCDIIHVKGKGRMKTWYLMGKKSSD 577
>UniRef50_Q5MAL1 Cluster: Adenylate cyclase; n=1; Aplysia
californica|Rep: Adenylate cyclase - Aplysia californica
(California sea hare)
Length = 1085
Score = 121 bits (291), Expect = 1e-25
Identities = 73/232 (31%), Positives = 129/232 (55%), Gaps = 15/232 (6%)
Query: 872 RERTEQLDMEKKKTEQLLNRMLPRSVAERLML---GSRVEPEEFEEVSIYFSDIVGFTA- 927
++ E+++ ++ +LL+ +LP VA+ + ++ E+ V + F+ IV F+
Sbjct: 840 QDEKEEMESLREYNLKLLSNILPLHVAKHFLSMKNDGKLYYEDINNVGVMFASIVNFSEF 899
Query: 928 ---LAARSTAVQVVDLLNDLYTTFDAAIEQYRVY---KVETIGDAYMVVGGLPQRTRDHA 981
L A + V+ + LLN++ FD + R + K++T+G YM GL RT +
Sbjct: 900 YMELEANNEGVECLRLLNEIIADFDTLLTHKRFFAVEKIKTVGQTYMCASGLTSRT-NFL 958
Query: 982 ESVATMALHLLHLAGRFRVRHLPDTPLH---LRIGLHTGPCCAGVVGLTMPRYCLFGDTV 1038
+ +AL A + ++ ++ + + +RIGL+ GP AGV+G P Y ++G+TV
Sbjct: 959 DMTHILALADYTFALKNQLEYINENSFNNFVMRIGLNIGPVVAGVIGAKKPHYDIWGNTV 1018
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
N ASRM+STG +IQ+++ ++L+ Y L RGL ++KGKG MHT++L
Sbjct: 1019 NVASRMDSTGEPNKIQVTA-EMYRILSKNKYSLSPRGLVRVKGKGDMHTFFL 1069
Score = 116 bits (280), Expect = 3e-24
Identities = 68/196 (34%), Positives = 108/196 (55%), Gaps = 12/196 (6%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERL---MLGSRVEP-------EEFEEVSIYFSDIVGFTA 927
+ E +K E+LL +LPR VA + + G++ E + + VSI F+DI GFTA
Sbjct: 281 MQKENQKQERLLLSVLPRHVAMEMKADIAGNKKEAMFHKIYIQRHDNVSILFADICGFTA 340
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATM 987
L++ TA ++V LLN+LY FD+ + +++ +GD Y V G+P RDHA M
Sbjct: 341 LSSTCTAQELVQLLNELYARFDSLATENHCLRIKLLGDCYYCVSGMPDPRRDHAHCAVEM 400
Query: 988 ALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
L ++ VR L T +++R+G+H+G GV+GL ++ ++ + V A+ MES
Sbjct: 401 GLDMVEAIA--LVRDLTGTNVNMRVGIHSGRVHCGVLGLYKWQFDVWSNDVTLANHMESG 458
Query: 1048 GAAWRIQISSTTAEKL 1063
G + ISS T + L
Sbjct: 459 GLPGHVHISSATKDYL 474
>UniRef50_Q238W6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Tetrahymena thermophila
SB210|Rep: Adenylate and Guanylate cyclase catalytic
domain containing protein - Tetrahymena thermophila SB210
Length = 2814
Score = 121 bits (291), Expect = 1e-25
Identities = 71/200 (35%), Positives = 118/200 (59%), Gaps = 9/200 (4%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLG---SRVE-PEEFEEVSIYFSDIVGFTALAAR 931
+ L + K+ Q+L+ +LP+ V E+ + +R+E + FE+V+I F+DI GFT +++
Sbjct: 2407 KNLSKKTKEQNQILSNLLPKHVLEKFLNNPETTRLELVDNFEDVTILFADIAGFTKYSSQ 2466
Query: 932 STAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAE---SVATMA 988
QVV++L L+ FD A ++ ++K+ TIGD Y+V+G R R+ AE +V M
Sbjct: 2467 VDPEQVVNMLKKLFYEFDKACQENEIFKLYTIGDCYVVIGFTDIRKRNPAEEAKNVLNMG 2526
Query: 989 LHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
+++ + + R + + L +RIG+HTG GV+G + RY ++G V A++MES+G
Sbjct: 2527 FNMIEIIKQLRAQ-VKFESLDMRIGVHTGKIIGGVIGTDIVRYDIYGRDVVIANKMESSG 2585
Query: 1049 AAWRIQISSTTAEKLLAAGG 1068
RI +SS T KLL G
Sbjct: 2586 EQGRILVSSQT-RKLLEPSG 2604
Score = 97.9 bits (233), Expect = 2e-18
Identities = 68/221 (30%), Positives = 114/221 (51%), Gaps = 10/221 (4%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFE-EVSIYFSDIVGFTALAARSTAV 935
+L +E K +L +LP+ V +R+ ++ E + EV++ F DI F + +S +
Sbjct: 1727 KLRIESAKINNILAILLPKFVRDRISNTGEIQLAENQGEVAVLFCDICDFDNIL-QSESE 1785
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAE-SVATMALHLLHL 994
++V LL++L+ FD Q K+ET+G Y+ GL ++ + +V L++L
Sbjct: 1786 KIVALLDNLFRNFDILCSQNDCTKIETVGKTYVAASGLSLELQNKKKHTVYNSVERLINL 1845
Query: 995 AGRFR--VRHLP----DTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
+ V+++ + ++IG+H G AGV+G P++ L GDT+NT SR+ STG
Sbjct: 1846 GFDMQDYVKNISWGKHGDKMRVKIGIHYGRVMAGVIGYHKPQFSLIGDTINTTSRVMSTG 1905
Query: 1049 AAWRIQISSTTAEKLLAAGGYKLR-SRGLTQIKGKGAMHTY 1088
R+ ISS K+ R +R + KGKG M TY
Sbjct: 1906 EDNRMTISSQAYAKIQTHNLSNYRTNRKEVEAKGKGVMVTY 1946
>UniRef50_A2DDF2 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1498
Score = 121 bits (291), Expect = 1e-25
Identities = 78/251 (31%), Positives = 133/251 (52%), Gaps = 10/251 (3%)
Query: 847 GRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR 906
G K N D+ + N EE I++R + ++ K K+E+LL ++LP+ + RL G +
Sbjct: 1229 GMKDNDNDTEINSIVFILTNEEEEIKKRKDA-EIAKAKSEKLLYQILPKDIVVRLNRGEK 1287
Query: 907 VEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQY-RVYKVETIGD 965
+ +I+F DIV F+ AA + +++ L+ +++TFD + +Y + K++ IGD
Sbjct: 1288 DISFTIPKATIFFVDIVKFSNYAAALSPSEIMSNLSLVFSTFDKIVVKYPTILKIKLIGD 1347
Query: 966 AYMVVGGL---PQRTRDH-AESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT-GPCC 1020
YM G+ PQ AE L + + + V+ L +RIG++T GP
Sbjct: 1348 VYMAAAGIFSDPQMNPSKPAEESVNCCLDIQKVMEQINVK--LSAGLEVRIGVNTGGPLI 1405
Query: 1021 AGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIK 1080
GV+G P + + GD +N ASR++ST ++QIS T E ++A + + RG +K
Sbjct: 1406 GGVLGTDKPTFDIIGDPINVASRLQSTDIPGKVQISQETKE-MIAGSNFVIEERGEVYLK 1464
Query: 1081 GKGAMHTYWLL 1091
GKG TY+++
Sbjct: 1465 GKGNRTTYFVM 1475
>UniRef50_UPI0000DB7A4D Cluster: PREDICTED: similar to Adenylyl
cyclase 78C CG10564-PA; n=2; Apocrita|Rep: PREDICTED:
similar to Adenylyl cyclase 78C CG10564-PA - Apis
mellifera
Length = 1299
Score = 120 bits (290), Expect = 2e-25
Identities = 76/237 (32%), Positives = 124/237 (52%), Gaps = 19/237 (8%)
Query: 872 RERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF----EEVSIYFSDIVGFTA 927
RE ++ ++ + QLL +LP VA + R PE + ++V + F+ + FT
Sbjct: 1028 RELSDMIE-SRHNNMQLLKNILPDHVAHHFLTQDRA-PELYSQSRDKVGVMFASVPNFTE 1085
Query: 928 LAARST--AVQVVDLLNDLYTTFDAAIEQYRVY---KVETIGDAYMVVGGLPQRTRDHAE 982
+ ++ + LLN++ FD +++ R + K++T+G YM GL D +
Sbjct: 1086 FYSEDVNKGMECIRLLNEIIADFDELLDENRFHCIEKIKTVGATYMAASGLNPCQNDKNK 1145
Query: 983 SVATMALHLLHLAGRFRVRHLPDTPLH------LRIGLHTGPCCAGVVGLTMPRYCLFGD 1036
L+ A R+R L D +H LR+G+ GP GV+G P + ++G+
Sbjct: 1146 DDMEHLCRLVDYAVAMRLR-LEDVNIHSFNNFDLRVGISCGPLVGGVIGARKPVFDIWGN 1204
Query: 1037 TVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
TVN ASRM+STG +IQ+ A + L + GY+ + RGL ++KGKG M TY++LGK
Sbjct: 1205 TVNLASRMDSTGVMGKIQVPQDIA-RFLESRGYQTQKRGLIEVKGKGTMETYFVLGK 1260
Score = 105 bits (251), Expect = 1e-20
Identities = 55/154 (35%), Positives = 86/154 (55%), Gaps = 2/154 (1%)
Query: 906 RVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGD 965
R+ +E VSI F+DI GFTALA++ +A ++V +LNDL+ FD + +++ +GD
Sbjct: 374 RIYIHRYENVSILFADIKGFTALASQCSAQELVKVLNDLFARFDKLSAENHCLRIKLLGD 433
Query: 966 AYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVG 1025
Y + GLP DHA M LH++ VR+ L++RIG+H+G GV+G
Sbjct: 434 CYYCICGLPIARSDHAHCCVEMGLHMIKAIR--DVRYTTKVDLNMRIGIHSGSVLCGVLG 491
Query: 1026 LTMPRYCLFGDTVNTASRMESTGAAWRIQISSTT 1059
L ++ ++ V A+ +ES G R+ IS T
Sbjct: 492 LRKWQFDVWSYDVTLANHLESGGIPGRVHISEDT 525
>UniRef50_A2EQT4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1579
Score = 120 bits (290), Expect = 2e-25
Identities = 76/227 (33%), Positives = 119/227 (52%), Gaps = 5/227 (2%)
Query: 865 NNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVG 924
+++ +L+++ E D K+K+E LL ++LP+ + RL G + SI F DIV
Sbjct: 1333 SDITKLLKQMKEAEDA-KQKSETLLFQILPKDIVVRLGRGEKDISFTVPSASIIFIDIVK 1391
Query: 925 FTALAARSTAVQVVDLLNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGGLPQRTRDHAES 983
F+ AA T +++ L+ ++ FD +++Y ++ K++ IGD YM GL D A
Sbjct: 1392 FSEYAASLTPQEIMGNLSTVFAAFDEMVKKYPKITKIKLIGDVYMAAAGLFDEQDDPASH 1451
Query: 984 VATMALHLLHLAGRF-RVRHLPDTPLHLRIGLHTG-PCCAGVVGLTMPRYCLFGDTVNTA 1041
M L G V + L +RIG++TG P AGV+G P + + GD +N A
Sbjct: 1452 AKDMVNFGLDCLGELDEVNVKLNASLEVRIGINTGGPLLAGVLGTDKPVFDIIGDPINIA 1511
Query: 1042 SRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
+R++ST A RIQIS T E + + + RG +KGKG TY
Sbjct: 1512 ARLQSTDIAGRIQISKATKE-YIENSNFNIEERGEVFLKGKGKQMTY 1557
>UniRef50_A2EN44 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1574
Score = 120 bits (290), Expect = 2e-25
Identities = 77/231 (33%), Positives = 121/231 (52%), Gaps = 10/231 (4%)
Query: 866 NLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGF 925
N E+L+ + +Q + EKKK+E+LL ++LPR + ++ G SI F DI F
Sbjct: 1330 NDEKLVMQM-KQAEDEKKKSEKLLYQILPRDIVNQINRGENDISFNVSTCSIIFIDINKF 1388
Query: 926 TALAARSTAVQVVDLLNDLYTTFDAAIEQYRVY-KVETIGDAYMVVGGL----PQRTRDH 980
+ AA T ++ L+ ++ D +Y + K++ IGD YM GL H
Sbjct: 1389 SEYAANLTPSMIMTNLSFYFSVLDKTAAKYPLLTKIKLIGDIYMGASGLFPTEDMTNESH 1448
Query: 981 AESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTG-PCCAGVVGLTMPRYCLFGDTVN 1039
AE AL +++ R DT L +R+G++TG P AGV+G P + + GD +N
Sbjct: 1449 AEQTCLFALDVMYQMDEINKRL--DTSLGIRVGINTGGPIIAGVLGTDKPLFDIIGDPIN 1506
Query: 1040 TASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
ASR++ST A I +S TAE L+ + + + RG T +KGKG T+++
Sbjct: 1507 VASRLQSTSAVNHIHVSKETAE-LVKSMNFDVIPRGQTALKGKGTQQTFYI 1556
>UniRef50_UPI000069F10A Cluster: Adenylate cyclase type 6 (EC 4.6.1.1)
(Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6)
(Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl
cyclase).; n=2; Coelomata|Rep: Adenylate cyclase type 6
(EC 4.6.1.1) (Adenylate cyclase type VI) (ATP
pyrophosphate-lyase 6) (Adenylyl cyclase 6)
(Ca(2+)-inhibitable adenylyl cyclase). - Xenopus
tropicalis
Length = 355
Score = 118 bits (285), Expect = 8e-25
Identities = 75/229 (32%), Positives = 126/229 (55%), Gaps = 15/229 (6%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF----EEVSIYFSDIVGFTA---- 927
E+++ + +LL+ +LP+ VA + E + E V++ F+ I F+
Sbjct: 122 EEMEQLQAYNRRLLHNILPKDVAAHFLAREHRNDELYYQSCECVAVMFASICNFSEFYVE 181
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTRDHAESV 984
L A + V+ + LLN++ FD I + + + K++TIG YM GL T D
Sbjct: 182 LEANNEGVECLRLLNEIIADFDEIISEEKFKQLEKIKTIGSTYMAASGLNDTTYDKEGKT 241
Query: 985 ATMALHLLHLAGRFRVRHLPDTPLH---LRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTA 1041
AL + R +++++ + + ++IGL+ GP AGV+G P+Y ++G+TVN A
Sbjct: 242 HITALADYAMKLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVA 301
Query: 1042 SRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
SRM+STG IQ+ +T ++LAA GY++ RG+ ++KGKG M TY+L
Sbjct: 302 SRMDSTGLPDCIQV-TTDLYQVLAAKGYQMECRGVIKVKGKGEMTTYFL 349
>UniRef50_A2DXM9 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 696
Score = 118 bits (283), Expect = 1e-24
Identities = 74/228 (32%), Positives = 118/228 (51%), Gaps = 8/228 (3%)
Query: 866 NLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGF 925
N + I + Q++ KK E+LLN++LP + +++ G +I F DI F
Sbjct: 441 NDQTQIERQMRQVEEAKKSAERLLNQILPPMIVQKMNAGETEISFTVNSATIIFIDIQKF 500
Query: 926 TALAARSTAVQVVDLLNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGGL--PQRTRD-HA 981
+ AA TA Q++ L ++ +D + ++ + K++ IGD YM GL P + D HA
Sbjct: 501 SDYAATLTARQIMQNLGRIFNYYDELVPKFPTLIKIKLIGDVYMAAAGLFNPDVSPDVHA 560
Query: 982 ESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDTVNT 1040
+ A+ LH G + + L +RIG++T GP AGV+G+ P + + GD +N
Sbjct: 561 TEMINFAIGCLH--GLEEANEILEASLSVRIGINTGGPIIAGVLGIDKPLFDIIGDPINV 618
Query: 1041 ASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
ASR++ST IQIS T + L+ G+ + RG +KGKG Y
Sbjct: 619 ASRLQSTDIPNMIQISQATYD-LIKDKGFNVAERGKIFLKGKGEQMAY 665
>UniRef50_UPI0000D5745B Cluster: PREDICTED: similar to CG32158-PB,
isoform B; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG32158-PB, isoform B - Tribolium castaneum
Length = 1333
Score = 117 bits (282), Expect = 2e-24
Identities = 77/235 (32%), Positives = 122/235 (51%), Gaps = 15/235 (6%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEE----VSIYFSDIVGFTA- 927
E E ++ + +LL +LP VAE + + E + E V I F+ I F+
Sbjct: 1058 EEKEDMEHLEAYNRKLLANILPVHVAEHFLNSDKNNDELYHEQCDFVCIMFASIPNFSEF 1117
Query: 928 ---LAARSTAVQVVDLLNDLYTTFDAAI--EQYR-VYKVETIGDAYMVVGGLPQRTRDHA 981
L + V+ + LLN++ FD + +Q++ + K+++ G YM GL Q T D
Sbjct: 1118 YVELEGNNEGVECLRLLNEIIADFDELLSEDQFKYIEKIKSTGATYMAASGLTQNTCDMQ 1177
Query: 982 --ESVATMALHLLHLAGRF-RVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTV 1038
V MA + L + + V +RIG++ GP AGV+G P+Y ++G+ V
Sbjct: 1178 GYRHVTAMADYALRIQEQLAEVNEHSFNHFRIRIGINVGPVVAGVIGARKPQYDIWGNAV 1237
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
N ASRM+STG +IQ++ + +L++ GY L RG Q+KGKG M TY+L G+
Sbjct: 1238 NVASRMDSTGVLDKIQVTKEVYQ-ILSSRGYPLTCRGTIQVKGKGTMETYFLEGR 1291
Score = 109 bits (262), Expect = 5e-22
Identities = 63/197 (31%), Positives = 105/197 (53%), Gaps = 12/197 (6%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE----------FEEVSIYFSDIVGFT 926
++ E ++ E+LL +LPR VA + +P+E E VSI F+DI GFT
Sbjct: 492 KIQRENQQQERLLLSVLPRHVAMEMKADIAGQPKEAQFHKIYIQRHENVSILFADICGFT 551
Query: 927 ALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVAT 986
L+ + TA ++V +LN+L+ FD ++ +++ +GD Y V GLP+ DHA
Sbjct: 552 TLSDQCTAEELVRILNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARPDHAHCTVE 611
Query: 987 MALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMES 1046
M L ++ VR + +++R+G+HTG GV+GL ++ ++ + V A+ MES
Sbjct: 612 MGLDMIDAIA--LVREVMSVNVNMRVGIHTGRVHCGVLGLRKWQFDVWSNDVTLANHMES 669
Query: 1047 TGAAWRIQISSTTAEKL 1063
G R+ I+ T + L
Sbjct: 670 GGIPGRVHITKETLKCL 686
>UniRef50_A2DJ96 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1593
Score = 117 bits (282), Expect = 2e-24
Identities = 76/225 (33%), Positives = 116/225 (51%), Gaps = 9/225 (4%)
Query: 869 ELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTAL 928
ELI +R + + K ++E+LL ++LPR + RL G +I F DIV F+
Sbjct: 1344 ELINQR-KSAEQAKAQSEKLLFQILPRDIVTRLNSGETDINFTVPSATIIFIDIVKFSNY 1402
Query: 929 AARSTAVQVVDLLNDLYTTFDAAIEQYR-VYKVETIGDAYMVVGGL---PQRTRDHAESV 984
AA + Q++D L+ ++ FD + +Y + K++ IGD YM GL HA +
Sbjct: 1403 AATLSPAQIMDHLSIIFAKFDTLVAKYNLITKIKLIGDVYMAAAGLFGTDIAPEKHASQM 1462
Query: 985 ATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDTVNTASR 1043
AL L ++ ++ L RIG++T GP AGV+G P + + GD +N ASR
Sbjct: 1463 VNFALE--SLTALDEANNMFNSNLMTRIGINTNGPLIAGVLGTDKPVFDIIGDPINVASR 1520
Query: 1044 MESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
++STG +QIS T KL+ Y + RG ++KGKG Y
Sbjct: 1521 LQSTGIPGTVQISEET-YKLIVNMNYNIERRGEIELKGKGKKMAY 1564
>UniRef50_UPI00006CB402 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2703
Score = 117 bits (281), Expect = 2e-24
Identities = 62/194 (31%), Positives = 111/194 (57%), Gaps = 8/194 (4%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLG---SRVEPEEFEEVSIYFSDIVGFTALAARS 932
+ L+ + ++T++L+ +LP+ + ER ++ S + E+F++ +I F+DI GFT + ++
Sbjct: 2477 QSLNEKNQQTDKLIQYLLPKHILERFLMNPTASYIIAEKFDKQTILFADIAGFTRYSDQN 2536
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD---HAESVATMAL 989
VV +L ++T FD + ++V+KV TIGD Y+++G RD A +V MA
Sbjct: 2537 QPETVVKMLRTIFTEFDQKCQYHKVFKVYTIGDCYVILGNTNHENRDPPTEAYNVIMMAF 2596
Query: 990 HLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
++ + R L + + +RIG+HTG G+VG + RY ++G V A++MES G
Sbjct: 2597 QMIEILK--RTTELVENQIDMRIGVHTGKIVGGLVGTQIVRYDIYGVDVMIANKMESNGQ 2654
Query: 1050 AWRIQISSTTAEKL 1063
+ +S TT + L
Sbjct: 2655 KGSVVVSETTKDIL 2668
Score = 95.5 bits (227), Expect = 8e-18
Identities = 69/245 (28%), Positives = 122/245 (49%), Gaps = 24/245 (9%)
Query: 866 NLEELIRER---TEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEE--VSIYFS 920
N EE+ R+ + L K + L+ +LPR + E+L G + + V++ F
Sbjct: 1790 NYEEIERKNFQVNQTLTQATSKMKDTLSILLPRFIREKLYSGQNYDKISTNQGNVAVLFC 1849
Query: 921 DIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGL---PQRT 977
DI F + + ++V +L++L+ FD + + +V K+ET+G YM GL +
Sbjct: 1850 DITNFDEIMMQEEE-KIVKVLDNLFRQFDKSCQANQVLKIETVGKTYMAAAGLRDVDEYY 1908
Query: 978 RDHAESVAT----------MALHLLHLAGRFRVRHLPDT----PLHLRIGLHTGPCCAGV 1023
+D V T +A+ + +A + + + ++IG++ G +GV
Sbjct: 1909 QDGQNQVNTFVDPVKRCLQVAMEMQEIAKNITWGNTNNGGKSGKVEIKIGINYGTVISGV 1968
Query: 1024 VGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKG 1083
+G P++ L GDTVNTASR+ STG I IS+++ +K++ Y+ R + + KGKG
Sbjct: 1969 IGFHKPQFSLIGDTVNTASRVCSTGLPKTINISNSSYQKVIQLSQYRFEKREV-EAKGKG 2027
Query: 1084 AMHTY 1088
+ TY
Sbjct: 2028 IITTY 2032
>UniRef50_A3WBP2 Cluster: Adenylate/guanylate cyclase; n=1;
Erythrobacter sp. NAP1|Rep: Adenylate/guanylate cyclase -
Erythrobacter sp. NAP1
Length = 420
Score = 117 bits (281), Expect = 2e-24
Identities = 73/211 (34%), Positives = 108/211 (51%), Gaps = 5/211 (2%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQV 937
L+ E+ KTE++L +LP++VA RL G V + F +VS+ F DIVGF+ LA + + +
Sbjct: 201 LEEERAKTEEMLFNVLPKNVANRLRRGE-VVADSFSDVSVVFVDIVGFSKLARKLSPGHL 259
Query: 938 VDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGR 997
V LLN ++ D + V KV+TIGDAY+ V G T + A S A ++
Sbjct: 260 VKLLNAIFGLADECAKNAGVEKVKTIGDAYLAVAGGTTSTENDAVSAIRFAEQMIAAVTD 319
Query: 998 FRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISS 1057
+ D + +R+G+HTGP GV+G Y +GDT+NTA+R+E I +S
Sbjct: 320 YARETRID--VAIRVGIHTGPVVGGVIGQQRMAYDYWGDTMNTAARLEGVAKPGGIAVSE 377
Query: 1058 TTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
+T A L +KG G Y
Sbjct: 378 ST--YFAACSQVDFTPAELQTLKGIGETKVY 406
>UniRef50_A2DY07 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1588
Score = 117 bits (281), Expect = 2e-24
Identities = 73/226 (32%), Positives = 123/226 (54%), Gaps = 8/226 (3%)
Query: 868 EELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTA 927
E I + EQ ++ KKK+E+LL ++LPR + +L G + +I F DIV F+
Sbjct: 1341 ESQILHKQEQAELAKKKSEELLFQILPRDIVFKLNQGEKDITFTVPSATIMFIDIVRFSD 1400
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGGL--PQ-RTRDHAES 983
AA T Q++ L+ ++ TFD + Y + K++ IGD YM GL P + +DHA+
Sbjct: 1401 YAANLTPQQIMGNLSLIFDTFDKHLTDYPLITKIKLIGDVYMCAAGLFTPDGQLQDHAQQ 1460
Query: 984 VATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDTVNTAS 1042
+ A+ LA + ++ L +R+G++T GP G++G P + + GD +N A+
Sbjct: 1461 MLRFAIDC--LAEIENINVALESMLSVRVGVNTGGPLIGGILGTDKPVFDIIGDPINVAA 1518
Query: 1043 RMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
R++ST ++QI + + L+ A + + RG +KGKG + TY
Sbjct: 1519 RLQSTDIPGKVQIPQSVYD-LVHAMEFNIEKRGEVYLKGKGNVTTY 1563
>UniRef50_Q16W55 Cluster: Adenylate cyclase; n=1; Aedes aegypti|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 554
Score = 116 bits (280), Expect = 3e-24
Identities = 80/241 (33%), Positives = 129/241 (53%), Gaps = 20/241 (8%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR------VEPEEFEEVSIYFSDIVG 924
+ ++ E+ +++ E L+ +LP VAE M G+R + + + EV + F+ +
Sbjct: 312 VSDQKERASDMRRRNEALVYNVLPMHVAEHFM-GNRKRSHDDLYSQSYAEVGVLFASMPN 370
Query: 925 FTALAARSTA----VQVVDLLNDLYTTFDAAIE--QYR-VYKVETIGDAYMVVGGL-PQR 976
F+ + T ++ + LN++ + FDA +E Q++ V K++TIG YM GL P R
Sbjct: 371 FSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDVIKIKTIGSTYMAASGLNPSR 430
Query: 977 TRDHAESVATMALHL---LHLAGRFR-VRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYC 1032
+ A +AL + L L + + L++G++ GP AGV+G P Y
Sbjct: 431 IDPISVRWAHLALLVEFALELKKALQGINEQSFNHFVLKMGVNHGPITAGVIGARKPHYD 490
Query: 1033 LFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
++G+TVN ASRMESTG A IQ++ T + +L GY RGL +KGKG + TY+L G
Sbjct: 491 IWGNTVNVASRMESTGKAGAIQVTEETCQ-ILQTFGYTFEQRGLVAVKGKGQLMTYYLQG 549
Query: 1093 K 1093
K
Sbjct: 550 K 550
>UniRef50_A0EAN1 Cluster: Chromosome undetermined scaffold_86, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_86, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2476
Score = 116 bits (280), Expect = 3e-24
Identities = 62/193 (32%), Positives = 114/193 (59%), Gaps = 7/193 (3%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAER---LMLGSRVEPEEFEEVSIYFSDIVGFTALAARST 933
+L + ++ +QL+ LP + ++ L V ++ E+V++ F+DI GFT +++
Sbjct: 2239 KLKYKHEQLDQLVKHQLPTHMLDQFLQLQQSRAVLKDQHEDVTLLFADIAGFTEYSSKVA 2298
Query: 934 AVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD---HAESVATMALH 990
QVV +L +L+T FD ++ VYK+ TIGD Y+V+G + + R+ A++ MA
Sbjct: 2299 PEQVVFMLRNLFTEFDKCCQEKNVYKLYTIGDCYVVMGMVDAKDRNPALEAKNTVEMAFE 2358
Query: 991 LLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
++++ + R + + ++ LH+RIG+HTG GV+G + RY ++G V A++MES
Sbjct: 2359 MINIIRKVRDK-INNSDLHMRIGIHTGKIIGGVLGTDIVRYDIYGPDVLIANKMESKSER 2417
Query: 1051 WRIQISSTTAEKL 1063
++Q+S TT + L
Sbjct: 2418 GQVQVSETTKKTL 2430
Score = 90.2 bits (214), Expect = 3e-16
Identities = 61/215 (28%), Positives = 106/215 (49%), Gaps = 5/215 (2%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFE-EVSIYFSDIVGFTALAARSTAV 935
QL+ + L+ ++P+ + + + +E + EV+I F DI F + +
Sbjct: 1659 QLNQKINSISDTLSILMPKFIRNMINQSGEFDIQENQGEVAILFCDICEFDTII-KVQQQ 1717
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLA 995
VV LL+ L+ +D+ QY + K+ET+G YM GL + + AL +
Sbjct: 1718 NVVHLLDILFRQYDSLCNQYNLQKIETVGKTYMAASGLKNLISQNNINPVFRALQVAFEM 1777
Query: 996 GRFRV-RHLPDTP-LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRI 1053
+F + T + ++IG+H G AGV+G P++ L GDTVNT SR+ ST +I
Sbjct: 1778 QKFASSQSFGQTENIVVKIGVHYGNVIAGVIGYHKPQFSLIGDTVNTTSRVCSTAQDNQI 1837
Query: 1054 QISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
+IS +++ + + + + + KGKG + TY
Sbjct: 1838 KISEEAYKQVSSCVDFTF-TLDIVEAKGKGQLTTY 1871
>UniRef50_A0EHP6 Cluster: Cation-transporting ATPase; n=3; Paramecium
tetraurelia|Rep: Cation-transporting ATPase - Paramecium
tetraurelia
Length = 2285
Score = 116 bits (279), Expect = 4e-24
Identities = 74/217 (34%), Positives = 120/217 (55%), Gaps = 10/217 (4%)
Query: 852 IVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQ--LLNRMLPRSVAERLMLGSRVEP 909
I+ S+ L Y + ELI E++K +Q L++++LP ++ +
Sbjct: 2006 ILSSLVLCLIGYYKGMSELIEMYNNLQLNEQRKAKQISLVSQLLPTHSYLKMKNNTLYNR 2065
Query: 910 EEF----EEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGD 965
EF ++V++ F+DI GFT + T VV +L +L+T FD QY VYK+ TIGD
Sbjct: 2066 SEFIDDLDDVTLLFADIKGFTEYSHTQTPEGVVTMLRNLFTEFDKLCLQYNVYKMYTIGD 2125
Query: 966 AYMVVGGLPQRTRDH--AESVATMALHLLHLAGRFRVRHLPDTP-LHLRIGLHTGPCCAG 1022
Y+V+ G Q T+ + E++ T+ + + VR L D P L++RIG+HTG G
Sbjct: 2126 CYVVM-GFQQATKRNPIQEAINTVKMGFSMIEIIMEVRKLIDFPLLNMRIGIHTGSIIGG 2184
Query: 1023 VVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTT 1059
++G + RY ++G V+ A++MES+G+ +QIS TT
Sbjct: 2185 IIGTDIVRYDIYGQDVSIANKMESSGSEGHVQISETT 2221
Score = 83.8 bits (198), Expect = 3e-14
Identities = 60/221 (27%), Positives = 107/221 (48%), Gaps = 16/221 (7%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQV 937
++ + +L+ ++P+ V ++ LGS E +VSI F + F ++ + V
Sbjct: 1493 IEQDNLAANDILSILVPKFVRNQIQLGSLHMQEAQNDVSILFCYVCDFDSIM-KEEGRNV 1551
Query: 938 VDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGL--------PQRTR-DHAESVATMA 988
V +L+ L+ FD Q+ V K+ET+G YM G+ P + + + MA
Sbjct: 1552 VLMLDSLFRIFDNLCLQHGVQKIETVGYTYMAATGIKASEINISPHMLKTEKTMRLVNMA 1611
Query: 989 LHLLH-LAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
++ + GR ++ + ++IG+H G AG++G P++ L GD VN SR+ ST
Sbjct: 1612 FDMMEQIQGR---QYGKGNQIEMKIGIHVGRVIAGLIGHHKPQFSLIGDPVNQTSRVGST 1668
Query: 1048 GAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
G I +S+ ++ A G K ++ + KG G + TY
Sbjct: 1669 GDVGAITLSAEAFKQ--AKQGIKYYNKKQKEAKGLGLIDTY 1707
>UniRef50_UPI00005A2FB4 Cluster: PREDICTED: similar to brain adenylate
cyclase 1; n=1; Canis lupus familiaris|Rep: PREDICTED:
similar to brain adenylate cyclase 1 - Canis familiaris
Length = 1161
Score = 115 bits (277), Expect = 7e-24
Identities = 75/236 (31%), Positives = 125/236 (52%), Gaps = 21/236 (8%)
Query: 876 EQLDMEKKKTE--QLLNRMLPRSVAERLMLGSR----VEPEEFEEVSIYFSDIVGFT--- 926
E+ DME+ K + ++L +LP VA+ ++ + + + + +V + F+ I F
Sbjct: 855 ERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFDDFY 914
Query: 927 -ALAARSTAVQVVDLLNDLYTTFDAAIEQ--YR-VYKVETIGDAYMVVGGLPQRT----- 977
L + V+ + LLN++ FD +++ Y+ + K++TIG YM GL T
Sbjct: 915 IELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTTGTKCI 974
Query: 978 RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDT 1037
H ++A A+ + + + D LR+G++ GP AGV+G P+Y ++G+T
Sbjct: 975 SSHLSTLADFAIEMFDVLDEINYQSYND--FVLRVGINVGPVVAGVIGARRPQYDIWGNT 1032
Query: 1038 VNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
VN ASRM+STG RIQ++ +LL G Y+ RG +KGKG M TY+L G+
Sbjct: 1033 VNVASRMDSTGVQGRIQVTE-EVHRLLRRGTYRFVCRGKVSVKGKGEMLTYFLEGR 1087
Score = 98.7 bits (235), Expect = 9e-19
Identities = 52/143 (36%), Positives = 80/143 (55%), Gaps = 2/143 (1%)
Query: 917 IYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQR 976
I F+DIVGFT LA++ TA ++V LLN+L+ FD + +++ +GD Y V GL Q
Sbjct: 229 ILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQP 288
Query: 977 TRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGD 1036
DHA M L ++ V + L++R+GLHTG GV+GL +Y ++ +
Sbjct: 289 KTDHAHCCVEMGLDMIDTI--TSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSN 346
Query: 1037 TVNTASRMESTGAAWRIQISSTT 1059
V A+ ME+ G ++ I+ TT
Sbjct: 347 DVTLANVMEAAGLPGKVHITRTT 369
>UniRef50_A2FAE9 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1576
Score = 115 bits (277), Expect = 7e-24
Identities = 71/231 (30%), Positives = 124/231 (53%), Gaps = 10/231 (4%)
Query: 866 NLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGF 925
N EE I+++ + + K K+E+LL ++LP+ + RL G +I+F DIV F
Sbjct: 1329 NEEEKIKQK-KLAEESKAKSEKLLYQILPKDIVVRLNRGETDISFTIPSATIFFIDIVKF 1387
Query: 926 TALAARSTAVQVVDLLNDLYTTFDAAIEQYR-VYKVETIGDAYMVVGGLPQ----RTRDH 980
++ A T +++ L+ ++ TFD + +++ + K++ IGD YM GL Q ++ H
Sbjct: 1388 SSYAELLTPSEIMANLSLVFATFDGIVSEFQSITKIKLIGDVYMAAAGLFQDPKEESKQH 1447
Query: 981 AESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTG-PCCAGVVGLTMPRYCLFGDTVN 1039
AE L ++ + L +RIG ++G P GV+G P + + GDT+N
Sbjct: 1448 AEDAVRCCLKCAKSMEEINMKL--NASLEVRIGCNSGGPLIGGVLGTDKPTFDIIGDTIN 1505
Query: 1040 TASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
A+R++ST +QIS++T E ++ + + RGL +KGKG TY++
Sbjct: 1506 VAARLQSTDIPGNVQISASTKE-MIEHLDFVIEERGLIYLKGKGKQMTYFV 1555
>UniRef50_Q4SUW5 Cluster: Chromosome undetermined SCAF13838, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF13838, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1085
Score = 115 bits (276), Expect = 9e-24
Identities = 72/202 (35%), Positives = 109/202 (53%), Gaps = 12/202 (5%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF---------EEVSIYFSD 921
I ER +L+ E +K E+LL +LPR+VA + PE + VSI F+D
Sbjct: 119 IEERL-RLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFAD 177
Query: 922 IVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHA 981
IVGFT+LA++ TA ++V LLN+L+ FD + +++ +GD Y V GL Q DHA
Sbjct: 178 IVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKADHA 237
Query: 982 ESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTA 1041
M L ++ V + L++R+GLHTG GV+GL +Y ++ + V A
Sbjct: 238 HCCVEMGLDMIDTIA--SVVEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLA 295
Query: 1042 SRMESTGAAWRIQISSTTAEKL 1063
+ ME+ G ++ I+ TT E L
Sbjct: 296 NVMEAGGLPGKVHITRTTLECL 317
Score = 59.3 bits (137), Expect = 7e-07
Identities = 45/125 (36%), Positives = 59/125 (47%), Gaps = 28/125 (22%)
Query: 994 LAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRI 1053
L G R PD L G++ GP AGV+G P+Y ++G+TVN ASRM+STG +I
Sbjct: 932 LGGGKRSERQPDV---LVTGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVPGKI 988
Query: 1054 QISS-------------------------TTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
Q+SS T L A Y+ RG +KGKG M TY
Sbjct: 989 QVSSGFRTHAAPPPAPPPALPPLAFLPQVTEDVHRLIAERYRFVCRGQVTVKGKGQMLTY 1048
Query: 1089 WLLGK 1093
+L G+
Sbjct: 1049 FLEGR 1053
>UniRef50_A2FLP2 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1568
Score = 115 bits (276), Expect = 9e-24
Identities = 73/226 (32%), Positives = 122/226 (53%), Gaps = 8/226 (3%)
Query: 868 EELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTA 927
E I ++ EQ ++ KKK+E+LL ++LPR + +L G + +I F DIV F+
Sbjct: 1320 ESQILKKQEQAELAKKKSEELLFQILPRDIVFKLNQGEKDITFTVPSATIMFIDIVRFSD 1379
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGGL--PQ-RTRDHAES 983
AA T Q++ L+ ++ TFD + Y + K++ IGD YM GL P + ++HA+
Sbjct: 1380 YAANLTPQQIMGNLSLIFDTFDRHLTDYPLITKIKLIGDVYMCAAGLFTPDGQPQEHAQQ 1439
Query: 984 VATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDTVNTAS 1042
+ A+ L V ++ L +RIG++T GP G++G P + + GD +N AS
Sbjct: 1440 MLHFAIDCLQEIENINV--TLESMLAVRIGVNTGGPLIGGILGTDKPVFDIIGDPINVAS 1497
Query: 1043 RMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
R++ST ++QI + + L+ + + RG +KGKG + TY
Sbjct: 1498 RLQSTDIPGKVQIPQSVFD-LVHNLDFNIEKRGEVYLKGKGNVTTY 1542
>UniRef50_A0BPN4 Cluster: Chromosome undetermined scaffold_12, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_12, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2459
Score = 115 bits (276), Expect = 9e-24
Identities = 71/203 (34%), Positives = 112/203 (55%), Gaps = 9/203 (4%)
Query: 865 NNLEELIRERTEQLD--MEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFE---EVSIYF 919
NN E IR + ++K++ + LL +LP + R S+++ E + + ++ F
Sbjct: 2209 NNFELTIRNFNSAANENLKKEQRDSLLTNLLPSHILTRFYQNSKIKLELSDVLIDATLLF 2268
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVG--GLPQR- 976
+DI GFTA +A A QVV +L L T+FD Q VYKV TIGD Y+V+G + QR
Sbjct: 2269 ADISGFTAYSASVPAEQVVKMLRQLMTSFDKECLQQNVYKVYTIGDCYVVLGINDMEQRH 2328
Query: 977 TRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGD 1036
A++V M L ++ + + R R + L++RIG+HTG G++G + RY +FG
Sbjct: 2329 PGQEAKNVLEMGLEMVEIIKKVR-REINFQNLNMRIGIHTGQFYGGIIGTDIVRYDIFGI 2387
Query: 1037 TVNTASRMESTGAAWRIQISSTT 1059
A++MES G A ++ +S T
Sbjct: 2388 DAVIANKMESQGEAGKVMVSEDT 2410
Score = 103 bits (248), Expect = 2e-20
Identities = 74/226 (32%), Positives = 111/226 (49%), Gaps = 21/226 (9%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFE-EVSIYFSDIVGFTALAARSTA 934
+ L ++++T Q+L +LP + E++ + EE + VSI F +I F + +S
Sbjct: 1611 QALQTQQEQTNQILKSLLPAFIYEKIEQAEETQIEENQGSVSIIFLEICEFDKIL-QSKQ 1669
Query: 935 VQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLP------------QRTRDHAE 982
QVV L+D++ D QY V K+ET+G YM GL Q+ ++
Sbjct: 1670 RQVVSFLDDIFRVLDKICLQYGVQKIETVGKTYMACSGLKSTEIENNKDGLNQQKKNETA 1729
Query: 983 SVATMALHLLHLAGRFRVRHLPDT-----PLHLRIGLHTGPCCAGVVGLTMPRYCLFGDT 1037
++L L FR + L ++IG+H G AGV+G P++ L GDT
Sbjct: 1730 LALELSLDFLKAVSEFRYEYKEQEIVKLYKLKIKIGIHYGQVFAGVIGYHKPQFSLIGDT 1789
Query: 1038 VNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKG 1083
VNTASRM STG RI ISS E++ + SR + + KGKG
Sbjct: 1790 VNTASRMCSTGEVGRITISSEAYERVKDT-EFLFTSREV-EAKGKG 1833
>UniRef50_O60503 Cluster: Adenylate cyclase type 9; n=29;
Euteleostomi|Rep: Adenylate cyclase type 9 - Homo sapiens
(Human)
Length = 1353
Score = 115 bits (276), Expect = 9e-24
Identities = 71/245 (28%), Positives = 128/245 (52%), Gaps = 5/245 (2%)
Query: 819 VMRQCWSEAPDLRPDFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQL 878
VM Q S + L+ + +H ++++ K ++ S+ + +++L + E +E
Sbjct: 300 VMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRI--IADDLMKQGDEESEN- 356
Query: 879 DMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVV 938
+++ T NR S+ + + + ++ EEVSI F+DIVGFT ++A +A +V
Sbjct: 357 SVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALV 416
Query: 939 DLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRF 998
LLNDL+ FD E+ + K+ T+GD Y V G P+ DHA M L ++ +F
Sbjct: 417 GLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQF 476
Query: 999 RVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISST 1058
+++R+G+HTG G++G+ ++ ++ + VN A+ ME G A ++ IS
Sbjct: 477 CQE--KKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEA 534
Query: 1059 TAEKL 1063
TA+ L
Sbjct: 535 TAKYL 539
Score = 97.9 bits (233), Expect = 2e-18
Identities = 67/219 (30%), Positives = 109/219 (49%), Gaps = 15/219 (6%)
Query: 882 KKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARST--AVQVVD 939
+ + + LL ++P VAE+L + S+ + + + F+ IV F+ + +
Sbjct: 1025 RDQADWLLRNIIPYHVAEQLKV-SQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYR 1083
Query: 940 LLNDLYTTFDAAIEQ---YRVYKVETIGDAYMVVGGLP-------QRTRDHAESVATMAL 989
+LN+L FD + + + K++TIG YM GL ++H + + A
Sbjct: 1084 VLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAK 1143
Query: 990 HLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
++ + F L LR+G + GP AGV+G T Y ++GDTVN ASRM++TG
Sbjct: 1144 EMMRVVDDFNNNMLWFN-FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
Query: 1050 AWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
RIQ+S + ++L+ GY RG +KGKG M TY
Sbjct: 1203 ECRIQVSE-ESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
>UniRef50_Q966F9 Cluster: Adenylyl cyclase protein 4; n=2;
Caenorhabditis|Rep: Adenylyl cyclase protein 4 -
Caenorhabditis elegans
Length = 954
Score = 114 bits (275), Expect = 1e-23
Identities = 78/242 (32%), Positives = 122/242 (50%), Gaps = 23/242 (9%)
Query: 876 EQLDMEKK--KTEQLLNRMLPRSVAERLMLG----SRVEPEEFEEVSIYFSDIVGFTALA 929
EQL M++K + +L +LP VA+ + S++ E + I F+ + F
Sbjct: 711 EQLQMKRKHEQNRSVLENILPSHVAKHFVEDATSVSKLYHESRDNACIMFATLTEFDKFY 770
Query: 930 ----ARSTAVQVVDLLNDLYTTFDAAIEQY-------RVYKVETIGDAYMVVGGLPQRT- 977
+ V+ + LLN++ + FD ++Q ++ K++TI YMV GL R
Sbjct: 771 IECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGLAGREC 830
Query: 978 --RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
H E++A A LL + + +LRIG++ GP AGV+G P Y ++G
Sbjct: 831 GDNSHVEAIALFARELLVKLESTNIHSFNN--FNLRIGINVGPVVAGVIGSDKPHYDIWG 888
Query: 1036 DTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEG 1095
++VN ASRM+S G A RIQ++ + +L GY RG +KGKG M T++LL E
Sbjct: 889 NSVNVASRMDSGGVAGRIQVTE-EVKSILEPLGYNFECRGQINVKGKGMMETFFLLPPED 947
Query: 1096 FD 1097
FD
Sbjct: 948 FD 949
Score = 101 bits (242), Expect = 1e-19
Identities = 61/199 (30%), Positives = 108/199 (54%), Gaps = 12/199 (6%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE----------FEEVSIYFSDIVGFTA 927
LD E + E++L +LP+++A + + EE +E++SI F+DI GFT
Sbjct: 195 LDKEMHRQEKILLAVLPKNIAFEVKKDMQETHEERMFHKIYIRKYEDISILFADICGFTN 254
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATM 987
LA+ +V +LN+L+ FD ++ +++ +GD Y V G+P+ ++HA + M
Sbjct: 255 LASEYNPKDLVLMLNELFARFDKVASIHQCMRIKILGDCYYCVCGVPEYQKNHAINTVEM 314
Query: 988 ALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
++ A R VR + +++R+G+HTG GV+GL ++ ++ + V A++MES
Sbjct: 315 GRDMIE-AIRL-VREMTLVNVNMRVGIHTGKAHCGVLGLKKWQFDVWSNDVTLANQMESG 372
Query: 1048 GAAWRIQISSTTAEKLLAA 1066
G A R+ I+ T L A
Sbjct: 373 GLAGRVHITDATRSYLKGA 391
>UniRef50_Q9VV68 Cluster: CG32158-PB, isoform B; n=12; Coelomata|Rep:
CG32158-PB, isoform B - Drosophila melanogaster (Fruit
fly)
Length = 1662
Score = 114 bits (274), Expect = 2e-23
Identities = 74/239 (30%), Positives = 121/239 (50%), Gaps = 15/239 (6%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR----VEPEEFEEVSIYFSDIVGFTA- 927
E E ++ + +LL +LP VAE + + + E+ + V I F+ I F+
Sbjct: 1055 EEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEF 1114
Query: 928 ---LAARSTAVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTRDHA 981
L + V+ + LLN++ FD + + R + K+++ G YM GL T D
Sbjct: 1115 YVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDRV 1174
Query: 982 E--SVATMALHLLHLAGRFRVRHLPD-TPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTV 1038
V MA + L L + ++ +RIG++ GP AGV+G P+Y ++G+ V
Sbjct: 1175 NFSHVTAMADYALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIWGNAV 1234
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEGFD 1097
N ASRM+STG IQ++ +++L G++L RG +KGKG+M TY+L G+ D
Sbjct: 1235 NVASRMDSTGLVDHIQVTQ-EMQQILEGRGFELTCRGSVDVKGKGSMITYFLKGRRPID 1292
Score = 106 bits (254), Expect = 4e-21
Identities = 63/193 (32%), Positives = 103/193 (53%), Gaps = 12/193 (6%)
Query: 881 EKKKTEQLLNRMLPRSVAERLMLGSRVEPEE----------FEEVSIYFSDIVGFTALAA 930
E ++ E+LL +LPR VA + +P + E VSI F+DI GFT+L+
Sbjct: 496 ENQQQERLLLSVLPRHVAMEMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSD 555
Query: 931 RSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALH 990
+ TA ++V LLN+L+ FD ++ +++ +GD Y V GLP+ DHA M L
Sbjct: 556 QCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLD 615
Query: 991 LLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
++ VR + +++R+G+HTG GV+GL ++ ++ + V A+ MES G
Sbjct: 616 MIDAIA--LVREVMAVNVNMRVGIHTGRVHCGVLGLVKWQFDVWSNDVTLANHMESGGIP 673
Query: 1051 WRIQISSTTAEKL 1063
R+ I+ T + L
Sbjct: 674 GRVHITKETLKCL 686
>UniRef50_A0CEN0 Cluster: Chromosome undetermined scaffold_172, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_172, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2514
Score = 114 bits (274), Expect = 2e-23
Identities = 68/218 (31%), Positives = 118/218 (54%), Gaps = 7/218 (3%)
Query: 852 IVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR---VE 908
I+ +F + Y N + +L + ++ + L+ LP + E+ + + V
Sbjct: 2247 ILQLIFISNQIYKFNKNVQLYNNKCKLKAKHQQLDSLVKHQLPSHMLEQFLKFQQQRAVL 2306
Query: 909 PEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYM 968
+ +E V++ F+DI GFT +++ + QVV +L +L+T FD ++ VYK+ TIGD Y+
Sbjct: 2307 KDSYENVTLLFADIAGFTEYSSKVSPEQVVFMLRNLFTEFDKCCQEKSVYKLYTIGDCYV 2366
Query: 969 VVGGLPQRTRD---HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVG 1025
V+G L + R+ A++ + ++ + R R H+ L +RIG+HTG GV+G
Sbjct: 2367 VMGMLDAKDRNIAQEAKNTVELGFEMISIIKRVR-DHINFQGLDMRIGIHTGNIIGGVLG 2425
Query: 1026 LTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKL 1063
+ RY ++G V A++MES G +Q+SSTT E L
Sbjct: 2426 TEIVRYDIYGPDVLIANKMESKGERGNLQVSSTTKEIL 2463
Score = 102 bits (245), Expect = 5e-20
Identities = 69/233 (29%), Positives = 118/233 (50%), Gaps = 7/233 (3%)
Query: 865 NNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFE-EVSIYFSDIV 923
N+ EE I+ T LD + L+ ++P+ + + + +E + EV+I F DI
Sbjct: 1696 NSREEFIQMLT--LDQQTNSISDTLSILMPKFIRNIINQKGEFDIQENQGEVAILFCDIC 1753
Query: 924 GFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAES 983
F + ++ V+ LL+ L+ +D+ QY + K+ET+G YM GL ++ +
Sbjct: 1754 QFDKII-KAEKENVIHLLDILFRQYDSLCSQYGLQKIETVGKTYMAAAGLKNIVSQNSAN 1812
Query: 984 VATMALHLLHLAGRFRVRH--LPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTA 1041
A+ + +F + + ++IG+H G AGV+G P++ L GDTVNT
Sbjct: 1813 PVLRAIQVAFEMRKFASQQDFCGSGEIIVKIGVHYGNVIAGVIGYHKPQFSLIGDTVNTT 1872
Query: 1042 SRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
SR+ STG +I+IS A KL++ + ++ + KGKG + TY L +E
Sbjct: 1873 SRVCSTGQDGQIKISE-DAYKLVSGSQDFIFTKDFVEAKGKGVLVTYILSEQE 1924
>UniRef50_P32870 Cluster: Ca(2+)/calmodulin-responsive adenylate
cyclase; n=5; Coelomata|Rep: Ca(2+)/calmodulin-responsive
adenylate cyclase - Drosophila melanogaster (Fruit fly)
Length = 2248
Score = 114 bits (274), Expect = 2e-23
Identities = 73/232 (31%), Positives = 126/232 (54%), Gaps = 15/232 (6%)
Query: 852 IVDSMFEMLEKYSN-NLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERL-------ML 903
+V+ M E ++ + + I R E D E +K E+LL +LP+ VA ++ +
Sbjct: 202 VVNIMMERAQRRTFLDTRNCIASRLEIQD-ENEKLERLLLSVLPQHVAMQMKNDILSPVA 260
Query: 904 GS--RVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVE 961
G R+ ++ E VSI F+DIVGFT L+++ +A ++V LLN+L+ FD +++
Sbjct: 261 GQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIK 320
Query: 962 TIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCA 1021
+GD Y V GLP+ +DHA+ M L ++ V D L++R+G+HTG
Sbjct: 321 ILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIA--TVVEATDVILNMRVGIHTGRVLC 378
Query: 1022 GVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRS 1073
GV+GL ++ ++ + V A+ MES G R+ ++ T + L +G Y++ +
Sbjct: 379 GVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSL--SGEYEVEA 428
Score = 101 bits (243), Expect = 9e-20
Identities = 66/238 (27%), Positives = 126/238 (52%), Gaps = 21/238 (8%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLM---LGSRVE--PEEFEEVSIYFSDIVGF-- 925
+ +++D+ ++ +++L+ +LP VA + + +E + + +V + F+ + F
Sbjct: 915 QEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNE 974
Query: 926 --TALAARSTAVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTRDH 980
T + ++ + LLN++ FD +++ R + K++T+G YM V GL +
Sbjct: 975 FYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQ 1034
Query: 981 AESVATMALHLLHLAGRFR-VRH-LPDTPLH------LRIGLHTGPCCAGVVGLTMPRYC 1032
++ H+ L + +RH L + H LR+G++ GP AGV+G P+Y
Sbjct: 1035 PNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYD 1094
Query: 1033 LFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
++G+TVN ASRM+STG Q++ + L+ + ++ R RG ++KGKG M TY+L
Sbjct: 1095 IWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGS-HFEFRCRGTIKVKGKGDMVTYFL 1151
>UniRef50_A2E4D6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=6; cellular organisms|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1529
Score = 113 bits (273), Expect = 2e-23
Identities = 71/213 (33%), Positives = 109/213 (51%), Gaps = 9/213 (4%)
Query: 881 EKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDL 940
E+ K+++LL +LP ++ R+ G + +I F DIV FT + +TA V
Sbjct: 1316 ERAKSDRLLASILPATLVPRVQAGEKNISFSVPSATIVFIDIVEFTPWCSSNTAQVVTGT 1375
Query: 941 LNDLYTTFDAAIEQYRVY-KVETIGDAYMVVGGLPQRTRD---HAESVATMALHLLHLAG 996
LND++T FD IE V +++ IGD YM GG+ T + A + L + G
Sbjct: 1376 LNDIFTEFDTIIESLPVMERIKCIGDCYMAAGGIFAETPNVLQFARAAVDFGLDAIAAIG 1435
Query: 997 RFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQI 1055
R +H L +R+G+H GP AGV+G P + +FG ++ A +ME G ++ +
Sbjct: 1436 RVNEKH--GMSLRVRVGVHIGGPIVAGVIGTGKPTFEIFGPAISMAQQMEHNGVPMKVHV 1493
Query: 1056 SSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
S + E L+ G YK+ RG QIK +G TY
Sbjct: 1494 SRSIYE-LIYGGTYKIEERGEIQIK-QGKALTY 1524
>UniRef50_A0P034 Cluster: Adenylate cyclase; n=1; Stappia aggregata
IAM 12614|Rep: Adenylate cyclase - Stappia aggregata IAM
12614
Length = 346
Score = 113 bits (272), Expect = 3e-23
Identities = 69/226 (30%), Positives = 109/226 (48%), Gaps = 8/226 (3%)
Query: 860 LEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYF 919
LE ++ ++ T +L+ + E+LL ++PR+V E V P+ +E VS+
Sbjct: 111 LESMIDSYSSMVERNTRELE----RVERLLLNLMPRTVYEEFKTFGVVTPQLYESVSVVM 166
Query: 920 SDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD 979
D VGFT +A + LND++T FD EQ+ +++TIGDAY+ V G+P+ + D
Sbjct: 167 LDFVGFTKFSAEHDPTVTLGELNDIFTAFDLITEQFGCERIKTIGDAYLAVSGMPEPSPD 226
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
H +VA + + R H R+GL TGP VVG+ Y +FG VN
Sbjct: 227 HMRAVANCPVRFIRYLERRNQSH--QHKWLARVGLGTGPAVGSVVGIQKYVYDVFGSAVN 284
Query: 1040 TASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAM 1085
A+R++ A + + A K + L G +I+ G M
Sbjct: 285 LAARLQE--FANPTCVVAPDAMKEFLVDEFHLEDLGKREIRSFGEM 328
>UniRef50_A0E8U0 Cluster: Cation-transporting ATPase; n=4; Paramecium
tetraurelia|Rep: Cation-transporting ATPase - Paramecium
tetraurelia
Length = 2302
Score = 113 bits (272), Expect = 3e-23
Identities = 64/195 (32%), Positives = 113/195 (57%), Gaps = 9/195 (4%)
Query: 877 QLDMEKK-KTEQLLNRMLPRSVAERLMLGSRVEP----EEFEEVSIYFSDIVGFTALAAR 931
Q++ +KK K L++++LP ++ S + +EFE+V++ F+DI GFT +
Sbjct: 2065 QINEDKKVKQINLVSQLLPMHSYLKMKNSSIYDKSDFIDEFEDVTLLFADIKGFTEYSHT 2124
Query: 932 STAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD---HAESVATMA 988
T VV +L +L+T FD ++Y VYK+ TIGD Y+V+G R+ A + M
Sbjct: 2125 QTPEGVVTMLRNLFTEFDKLCQRYNVYKMYTIGDCYVVMGFTNSAKRNPIQEAINTVKMG 2184
Query: 989 LHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
++ + + R++ + L++RIG+HTG G++G + RY ++G V+ A++MES+G
Sbjct: 2185 FQMVEIIMQVRLK-IKFDKLNMRIGIHTGQVTGGIIGTDIVRYDIYGKDVSIANKMESSG 2243
Query: 1049 AAWRIQISSTTAEKL 1063
R+Q+S TT + +
Sbjct: 2244 EEGRVQVSQTTKQMI 2258
Score = 84.6 bits (200), Expect = 2e-14
Identities = 58/218 (26%), Positives = 105/218 (48%), Gaps = 10/218 (4%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQV 937
++ + + +L+ ++PR V +++ G + ++VSI F+ I F + + V
Sbjct: 1532 IEQDNMTAQDILSILVPRFVRQQISTGIYSMQQAQDDVSILFAYICDFDTIM-KEEGKNV 1590
Query: 938 VDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESV--ATMALHLLHLA 995
V +L+ L+ +D Q+ V K+ET+G YM G+ ++ V + L+++A
Sbjct: 1591 VLMLDSLFRLYDNLCIQHGVQKIETVGYTYMAATGIKACEQNMTAHVIRTEKTMRLVNMA 1650
Query: 996 GRFRV-----RHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
++ + ++IG+H G AGV+G P++ L GD VN SR+ STG
Sbjct: 1651 FDMMQQVQGRKYGKGNQIEMKIGIHVGRVIAGVIGHHKPQFSLIGDPVNQTSRVGSTGDT 1710
Query: 1051 WRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
I +S ++ A G K S+ + KG G + TY
Sbjct: 1711 GAITLSEQAFKQ--ARHGIKYYSKKQKEAKGLGIIDTY 1746
>UniRef50_Q54H45 Cluster: Protein kinase, TKL group; n=1;
Dictyostelium discoideum AX4|Rep: Protein kinase, TKL
group - Dictyostelium discoideum AX4
Length = 690
Score = 113 bits (271), Expect = 4e-23
Identities = 71/221 (32%), Positives = 111/221 (50%), Gaps = 16/221 (7%)
Query: 627 LMQNLRQENVNPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVK 685
LM+NLR NV F+G CL + + RGSL +L + IK+ W+ ++ D K
Sbjct: 439 LMKNLRHPNVIQFLGSCLISPDICICTEYMPRGSLYSILHNEKIKISWSLVKRMMIDAAK 498
Query: 686 GMRYLHGS-PLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTA 744
G+ YLHGS P+ H L S N +VD W ++V D+GL + + A TP WT+
Sbjct: 499 GIIYLHGSTPVILHRDLKSHNLLVDENWKVKVADFGLSTIEQQGATMTACGTP---CWTS 555
Query: 745 PELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIR 804
PE++R R T+ DV+SF II+ E R +PY P ++I + R +R
Sbjct: 556 PEVLRSQR------YTEKADVYSFGIILWECATRQDPY--FGIPPFQVIFAVGREG--MR 605
Query: 805 PSVSMGAAPPEAVSVMRQCWSEAPDLRPDFNRLHDVFRQMQ 845
P PP+ + +++ C +E P RP + ++ ++
Sbjct: 606 PPTPK-YGPPKYIQLLKDCLNENPSQRPTMEQCLEILESIE 645
>UniRef50_Q1MU16 Cluster: ORF for hypothetical protein; n=2;
Apocrita|Rep: ORF for hypothetical protein - Apis
mellifera (Honeybee)
Length = 998
Score = 113 bits (271), Expect = 4e-23
Identities = 66/194 (34%), Positives = 115/194 (59%), Gaps = 13/194 (6%)
Query: 877 QLDMEKKKTEQ--LLNRMLPRSVAERLM--LGSRVEPE-------EFEEVSIYFSDIVGF 925
QL +E++ TEQ LL +LP VA ++ LG+ ++ + E VSI ++DIVGF
Sbjct: 223 QLVIEEQSTEQERLLLSVLPEHVAVKMRQDLGASLDTQFKKIYMSRHENVSILYADIVGF 282
Query: 926 TALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVA 985
TA+++ +A ++V +LN+L+ FD E++ +++ +GD Y + G P DHA
Sbjct: 283 TAISSTYSASELVKILNELFARFDQLSERFEQLRIKILGDCYYCISGAPIERPDHAVLCV 342
Query: 986 TMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRME 1045
M L ++ A ++ V+ ++P+ +R+G+HTG AGV+G ++ ++ V A++ME
Sbjct: 343 YMGLSMVE-AIKY-VQQTTNSPVDMRVGIHTGAVLAGVLGQRQWQFDVYSKDVELANKME 400
Query: 1046 STGAAWRIQISSTT 1059
S+G A R+ IS+ T
Sbjct: 401 SSGMAGRVHISNAT 414
Score = 109 bits (262), Expect = 5e-22
Identities = 71/245 (28%), Positives = 123/245 (50%), Gaps = 22/245 (8%)
Query: 869 ELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR----VEPEEFEEVSIYFSDIVG 924
E++ +R DM K++ L+ +LP VA + +R + + + EV + F+ +
Sbjct: 738 EVVAQRERAADM-KRRNGALIYNILPPHVAAYFLSRARHHDDLYSQSYAEVGVLFASMPN 796
Query: 925 FTALAARST----AVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRT 977
F + + ++ + LN++ + FDA ++Q + + K++TIG YM G+ +
Sbjct: 797 FADFYSEESINNQGLECLRFLNEVISDFDAILDQNKFKDIIKIKTIGSTYMAASGITESA 856
Query: 978 RD-------HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPR 1030
H ++ AL L + L++G++ GP AGV+G P
Sbjct: 857 ESEDGPRWGHLSTLVEFALELKKALSSINEQSF--NHFVLKMGINHGPVTAGVIGARKPH 914
Query: 1031 YCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
Y ++G+TVN ASRMESTG IQ++ T K+L G+ RGL +KGKG + T++L
Sbjct: 915 YDIWGNTVNVASRMESTGKVGCIQVTDET-RKILEPFGFGFEQRGLVFVKGKGQLLTHYL 973
Query: 1091 LGKEG 1095
+ K+G
Sbjct: 974 VSKDG 978
>UniRef50_A7AX98 Cluster: Adenylate and guanylate cyclase catalytic
domain containing protein; n=1; Babesia bovis|Rep:
Adenylate and guanylate cyclase catalytic domain
containing protein - Babesia bovis
Length = 2446
Score = 113 bits (271), Expect = 4e-23
Identities = 78/237 (32%), Positives = 123/237 (51%), Gaps = 25/237 (10%)
Query: 882 KKKTEQLLNRMLPRSVAERLMLGSRV---------EPEEFEEVSIYFSDIVGFTALAARS 932
+KK +LLN MLP V + M+ +R+ E EE VS+ F D+ F L A
Sbjct: 1555 RKKQSELLNTMLPTFVVTK-MINARLNEDGIPIGFEAEEHTLVSVVFCDVCNFQNLVATV 1613
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT----RDHAESVATMA 988
+V+LL+ L+ FD EQ+ K+ET+ + Y+ GL + + A + MA
Sbjct: 1614 EPTILVELLDSLFLAFDRCAEQFGATKIETVFETYLAALGLSRGNIICPYEAAANSIDMA 1673
Query: 989 LHLLHLAGRFRVRHLP----------DTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTV 1038
L ++ +A R + D +++G+++G +G+VG P+Y LFGDTV
Sbjct: 1674 LAMIEVARSIRYTSMQERDDGTFAEQDDVAVVKVGINSGKIISGLVGFKKPQYALFGDTV 1733
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEG 1095
NTASRM++TG + I IS++T + + + R T +KGKG M+T+ L+ EG
Sbjct: 1734 NTASRMKTTGESGYIHISTSTYDLVKSDVTLHFEHRE-TFVKGKGIMNTHLLISAEG 1789
Score = 101 bits (242), Expect = 1e-19
Identities = 70/186 (37%), Positives = 96/186 (51%), Gaps = 5/186 (2%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAV 935
E+ M + + Q+LN MLP+SV E E++S FSDIVGFT A A
Sbjct: 2216 EKARMIEARVGQMLNDMLPKSVLEEFKHDKLKMSYCHEKMSFLFSDIVGFTLWANSVDAG 2275
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLA 995
QV+ LL L+ FD + ++ +YK+ TIGDAY+ V E++A + L
Sbjct: 2276 QVITLLQRLFARFDRSSTKHGLYKLCTIGDAYVAVSEPAIEVPTEQEAIANIDGILQMAQ 2335
Query: 996 GRFR----VRHLPDTP-LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
R VR D P L++RIGLH G GV+G RY L+G ++TA+ MES G
Sbjct: 2336 SMIRTIRDVRESFDIPGLNMRIGLHYGHAVGGVIGSGRLRYDLWGMDIHTANAMESHGIP 2395
Query: 1051 WRIQIS 1056
+I IS
Sbjct: 2396 GKINIS 2401
>UniRef50_A2DLQ6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1545
Score = 113 bits (271), Expect = 4e-23
Identities = 68/216 (31%), Positives = 110/216 (50%), Gaps = 9/216 (4%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQV 937
+D E+ K+++LL +LP + R+ G + + S+ F DIV FT A +V
Sbjct: 1330 IDEERGKSDKLLESILPAKLVRRVQQGEKNISFSVQSASVVFMDIVSFTPWCGSLPANRV 1389
Query: 938 VDLLNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGGLPQRTRD---HAESVATMALHLLH 993
+++LN LY FDA + + + K++ IGD YM GG+ HA+ + + +
Sbjct: 1390 MEILNRLYKEFDAKVASFPTMTKIKCIGDCYMAAGGIFAEINQPAVHAKEIVEFGIEAIG 1449
Query: 994 LAGRFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWR 1052
G V L +R+G++T GP AGV+G P + + G T+N A +ME G +
Sbjct: 1450 AVG--VVNEETKQSLQIRVGINTGGPLVAGVLGSGKPTFEILGPTINMAQQMEHHGVPMQ 1507
Query: 1053 IQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
+ IS E L+ G +K++ RG +IK G + TY
Sbjct: 1508 VHISRAVYE-LIYGGNFKIKERGQIEIK-NGTVVTY 1541
>UniRef50_Q08828 Cluster: Adenylate cyclase type 1 (EC 4.6.1.1)
(Adenylate cyclase type I) (ATP pyrophosphate-lyase 1)
(Adenylyl cyclase 1) (Ca(2+)/calmodulin- activated
adenylyl cyclase); n=27; Euteleostomi|Rep: Adenylate
cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I)
(ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase) - Homo
sapiens (Human)
Length = 1119
Score = 113 bits (271), Expect = 4e-23
Identities = 67/192 (34%), Positives = 103/192 (53%), Gaps = 11/192 (5%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF---------EEVSIYFSDIVGFTA 927
+L+ E +K E+LL +LPR+VA + PE + VSI F+DIVGFT
Sbjct: 255 RLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTG 314
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATM 987
LA++ TA ++V LLN+L+ FD + +++ +GD Y V GL Q DHA M
Sbjct: 315 LASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEM 374
Query: 988 ALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
L ++ V + L++R+GLHTG GV+GL +Y ++ + V A+ ME+
Sbjct: 375 GLDMIDTI--TSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAA 432
Query: 1048 GAAWRIQISSTT 1059
G ++ I+ TT
Sbjct: 433 GLPGKVHITKTT 444
Score = 110 bits (265), Expect = 2e-22
Identities = 75/239 (31%), Positives = 123/239 (51%), Gaps = 24/239 (10%)
Query: 876 EQLDMEKKKTE--QLLNRMLPRSVAERLMLGSR----VEPEEFEEVSIYFSDIVGFT--- 926
E+ DMEK K + ++L +LP VA+ ++ + + + + +V + F+ I F
Sbjct: 822 EREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFY 881
Query: 927 -ALAARSTAVQVVDLLNDLYTTFDAAIEQ--YR-VYKVETIGDAYMVVGGLPQRT----- 977
L + V+ + LLN++ FD +E+ Y+ + K++TIG YM GL +
Sbjct: 882 IELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAK 941
Query: 978 ---RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLF 1034
H ++A A+ + + + D LR+G++ GP AGV+G P+Y ++
Sbjct: 942 KSISSHLSTLADFAIEMFDVLDEINYQSYND--FVLRVGINVGPVVAGVIGARRPQYDIW 999
Query: 1035 GDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
G+TVN ASRM+STG RIQ++ +LL Y RG +KGKG M TY+L G+
Sbjct: 1000 GNTVNVASRMDSTGVQGRIQVTE-EVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGR 1057
>UniRef50_UPI000069E679 Cluster: Adenylate cyclase type 1 (EC 4.6.1.1)
(Adenylate cyclase type I) (ATP pyrophosphate-lyase 1)
(Adenylyl cyclase 1) (Ca(2+)/calmodulin- activated
adenylyl cyclase).; n=2; Xenopus tropicalis|Rep:
Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase
type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase). -
Xenopus tropicalis
Length = 953
Score = 112 bits (270), Expect = 5e-23
Identities = 68/196 (34%), Positives = 105/196 (53%), Gaps = 11/196 (5%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF---------EEVSIYFSDIVGFTA 927
+L+ E +K E+LL +LPR+VA + PE + VSI F+DIVGFT+
Sbjct: 103 RLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTS 162
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATM 987
LA++ TA ++V LLN+L+ FD + +++ +GD Y V GL Q DHA M
Sbjct: 163 LASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEM 222
Query: 988 ALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
L ++ V + L++R+GLHTG GV+GL +Y ++ + V A+ ME+
Sbjct: 223 GLDMIDTI--TSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAG 280
Query: 1048 GAAWRIQISSTTAEKL 1063
G ++ I+ T E L
Sbjct: 281 GLPGKVHITKNTLECL 296
Score = 108 bits (259), Expect = 1e-21
Identities = 73/242 (30%), Positives = 128/242 (52%), Gaps = 20/242 (8%)
Query: 871 IRERTEQLDMEKKKTE--QLLNRMLPRSVAERLMLGSR----VEPEEFEEVSIYFSDIVG 924
++ E+ DME+ K + ++L +LP VA+ ++ + + + + +V + F+ I
Sbjct: 709 VQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 768
Query: 925 FT----ALAARSTAVQVVDLLNDLYTTFDAAIEQ--YR-VYKVETIGDAYMVVGGLPQRT 977
F L + V+ + LLN++ FD +E+ Y+ + K++TIG YM GL T
Sbjct: 769 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGLVPTT 828
Query: 978 RDHAES-----VATMALHLLHLAGRF-RVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRY 1031
A+ ++T+A + + + + LR+G++ GP AGV+G P+Y
Sbjct: 829 GTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNEFVLRVGINVGPVVAGVIGARRPQY 888
Query: 1032 CLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLL 1091
++G+TVN ASRM+STG +IQ++ ++L + Y+ RG +KGKG M TY+L
Sbjct: 889 DIWGNTVNVASRMDSTGVQGKIQVTE-DVHRILKSCNYEFVCRGKVSVKGKGEMLTYFLE 947
Query: 1092 GK 1093
GK
Sbjct: 948 GK 949
>UniRef50_A0C5P9 Cluster: Chromosome undetermined scaffold_150, whole
genome shotgun sequence; n=5; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_150, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2413
Score = 112 bits (270), Expect = 5e-23
Identities = 68/195 (34%), Positives = 108/195 (55%), Gaps = 10/195 (5%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGS---RVEPEEFEEVSIYFSDIVGFTALAARS 932
+QL + K + LLN +LP++V E + RV E+ +EV++ F+DI GFT ++
Sbjct: 2186 KQLIEKSIKYQFLLNYLLPKNVLEEFFRPNEEKRVLREQADEVTLLFADIAGFTEYSSSV 2245
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVG------GLPQRTRDHAESVAT 986
QVV++L +L+T FD + V+K+ TIGD Y+V+G G+ + A +V
Sbjct: 2246 QPEQVVNMLRNLFTEFDKNCLLHNVFKLYTIGDCYVVMGMVDYGKGIQRNPSQEAVNVVR 2305
Query: 987 MALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMES 1046
M ++ R R H+ L +RIG+HTG GV+G + RY ++G V A++MES
Sbjct: 2306 MGFAMIDAIRRVRA-HINHPTLDMRIGVHTGSIIGGVLGTELVRYDIYGPDVLIANKMES 2364
Query: 1047 TGAAWRIQISSTTAE 1061
GA +Q+S T +
Sbjct: 2365 KGAKGFVQVSQETKD 2379
Score = 100 bits (239), Expect = 3e-19
Identities = 66/219 (30%), Positives = 110/219 (50%), Gaps = 8/219 (3%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEE-VSIYFSDIVGFTALAARSTAVQ 936
++ E + +L+ +LP+ + +R+ + + +E + V++ F DI+ F L +
Sbjct: 1597 MNKENQIMSDILSILLPQFIRDRINKAGQYDIQEDQGMVAVLFCDIIDFDQLIKNEQS-N 1655
Query: 937 VVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAG 996
VVD+L+ L+ FD +Q+ V K+ET+G YM GL + H + ++ LA
Sbjct: 1656 VVDILDKLFRRFDLLCQQHEVQKIETVGKTYMAAAGL----KIHMSQKSNPVNKVISLAL 1711
Query: 997 RFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
+ + + ++IG+H G AGV+G P++ L GDT+NTASR+ ST W I IS
Sbjct: 1712 DMKRHVMSNEVFQIKIGIHYGNVIAGVIGHHKPQFSLIGDTINTASRICSTAEPWDIAIS 1771
Query: 1057 STTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEG 1095
A + R + KGKG + TY + K G
Sbjct: 1772 E-QAYRQTNKFELVYVQRDVV-AKGKGKLITYVVNTKRG 1808
>UniRef50_UPI00015B5E7D Cluster: PREDICTED: similar to adenylate
cyclase type ix; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to adenylate cyclase type ix - Nasonia
vitripennis
Length = 1314
Score = 112 bits (269), Expect = 7e-23
Identities = 56/184 (30%), Positives = 100/184 (54%), Gaps = 2/184 (1%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAV 935
E+ + E+++ + L +P + + L ++VSI F+DIVGFT +++ TA
Sbjct: 323 EESEREREREDSLKKGSIPSNNTDIRSLFRPFNMHSMDDVSILFADIVGFTKMSSNKTAE 382
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLA 995
++V +LNDL+ FD E + K+ T+GD Y V G P+ DHA+ M L ++
Sbjct: 383 ELVGILNDLFERFDDLCELHGCEKISTLGDCYYCVSGCPEPRPDHAKCCVEMGLAMIEAI 442
Query: 996 GRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQI 1055
+F + +++R+G+HTG G+VG ++ ++ + V A+++ESTG R+ +
Sbjct: 443 KQFDIERREG--VNMRVGVHTGTVLCGIVGTKRFKFDVWSNDVTLANKLESTGKPGRVHL 500
Query: 1056 SSTT 1059
S T
Sbjct: 501 SEKT 504
Score = 101 bits (241), Expect = 2e-19
Identities = 76/249 (30%), Positives = 122/249 (48%), Gaps = 14/249 (5%)
Query: 857 FEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVS 916
FE+ + S + + ++ K + + LL+ ++P+ VA++L ++ + + V
Sbjct: 1068 FEISYRLSFHGNAVAARDKSRVQSMKNQADWLLHNIIPKYVADQLKTTAKYS-QNHKAVG 1126
Query: 917 IYFSDIVGFTALAARST--AVQVVDLLNDLYTTFDAAIEQY---RVYKVETIGDAYMVVG 971
I F+ IV F L S + + +LN+L FD +E+ V K++TIG +M
Sbjct: 1127 IIFATIVNFNELYDESYLGGKEYLRVLNELIGDFDELLEKQDYSNVEKIKTIGSTFMAAS 1186
Query: 972 GLPQRTRDHAESVATMALHLLHLA-GRFRV-----RHLPDTPLHLRIGLHTGPCCAGVVG 1025
GL + R +E T LL A +V + L L LR+G + G AGV+G
Sbjct: 1187 GLNPQVRQQSEHEHTHIYQLLDFAMAMHKVIYDFNQDLLGFKLILRVGFNFGDVTAGVIG 1246
Query: 1026 LTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAM 1085
+ Y ++GD VN ASRM+STG A IQ +S + + A Y RG +KGK M
Sbjct: 1247 SSKLYYDIWGDAVNIASRMDSTGVAGEIQFASNCLD--VIAERYNYEPRGQVYVKGKDNM 1304
Query: 1086 HTYWLLGKE 1094
+ + L GK+
Sbjct: 1305 NVFLLKGKK 1313
>UniRef50_UPI0000D56082 Cluster: PREDICTED: similar to adenylate
cyclase 8; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to adenylate cyclase 8 - Tribolium castaneum
Length = 912
Score = 112 bits (269), Expect = 7e-23
Identities = 73/235 (31%), Positives = 118/235 (50%), Gaps = 18/235 (7%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLG-------SRVEPEEFEE--------VSI 917
E + E +K QL+ +LP VA+ + V+P++F + VSI
Sbjct: 86 ENRFKAQQENEKQVQLIFSILPDFVAKEMFADIENEERRGSVQPQQFHKIYIHKYNNVSI 145
Query: 918 YFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT 977
F+DI GFTALA++ TA ++V LNDL+ FD ++ +++ +GD Y V GLP
Sbjct: 146 LFADIKGFTALASKCTAQELVRNLNDLFARFDKLATKHDCLRIKLLGDCYYCVSGLPNAR 205
Query: 978 RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDT 1037
DHA+ M L+++ + + D + +RIG+H+G GV+GL ++ ++
Sbjct: 206 EDHADCAVEMGLNMIKAIKDTKTKTQVD--IDMRIGIHSGSVLCGVLGLRKWQFDIWSHD 263
Query: 1038 VNTASRMESTGAAWRIQISSTTAEKLLAAGGYK-LRSRGLTQIKGKGAMHTYWLL 1091
V A+RME+TG A R+ IS T L + R + K + TY++L
Sbjct: 264 VKIANRMEATGIAGRVHISDATLRALTKEFRVEAAHGREKDSLLRKNDIQTYFIL 318
Score = 107 bits (256), Expect = 2e-21
Identities = 69/224 (30%), Positives = 115/224 (51%), Gaps = 17/224 (7%)
Query: 887 QLLNRMLPRSVAERLMLGSRVEPEEFEE----VSIYFSDIVGFTALAARSTAVQVVDLLN 942
QLL +LP VA+ + E + + + + F+ I F+ + + ++ + LLN
Sbjct: 652 QLLTNVLPEHVAKHFLSREYRNEELYSQARDGIGVLFATIPNFSKFYSEAKGLECLRLLN 711
Query: 943 DLYTTFDAAIEQYR---VYKVETIGDA--YMVVGGLPQRTR------DHAESVATMALHL 991
++ TFD ++ R + K++T+ YM V GL + D E + +
Sbjct: 712 EIIATFDEVLDDERFSSIEKIKTVSATATYMAVSGLNPSIKHDPLIGDTPEHLGALIDFA 771
Query: 992 LHLAGRFR-VRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
+ L R + +LR+G+ G GV+G P + ++G+TVN ASRM+STG
Sbjct: 772 ITLRQRLEEINRDSFNRFNLRVGISYGDLVCGVIGAKKPIFDVWGNTVNEASRMDSTGLM 831
Query: 1051 WRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKE 1094
IQ+ TA+ LL GY+L+ RGL ++KGKG M T+++LGK+
Sbjct: 832 GEIQVPKNTAQ-LLVHQGYELKKRGLVRVKGKGLMETFFVLGKK 874
>UniRef50_Q5MAL2 Cluster: Adenylate cyclase; n=1; Aplysia
californica|Rep: Adenylate cyclase - Aplysia californica
(California sea hare)
Length = 1246
Score = 112 bits (269), Expect = 7e-23
Identities = 80/262 (30%), Positives = 133/262 (50%), Gaps = 18/262 (6%)
Query: 850 INIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP 909
++ +D E + + + + TEQ+ M + +L ++P V + SR
Sbjct: 980 MHFLDRQMEYANRLGHLFKMQFQRETEQVKMMAAINKIVLENIIPSHVIAYYLRSSRKHE 1039
Query: 910 ----EEFEEVSIYFSDIVGFTALAARSTA----VQVVDLLNDLYTTFDA-AIEQYR-VYK 959
E +E VS+ F+ I F ++ + ++ + +LN++ + FD I++++ V K
Sbjct: 1040 DLYHEAYESVSVMFASIPNFKDFYQQTKSNGEGMECIRVLNEIISDFDLLVIKKFQDVEK 1099
Query: 960 VETIGDAYMVVGGLPQ----RTRDHA--ESVATMALHLLHLAGRF-RVRHLPDTPLHLRI 1012
++TIG YM GL + D A ++ TM L + V LRI
Sbjct: 1100 IKTIGSTYMAATGLHRGQAGNQDDEAGERTIVTMVEFSLAMMSTLDTVNQHSFNNFSLRI 1159
Query: 1013 GLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLR 1072
G++ GP AGV+G P+Y ++GDTVN ASRM+S+G +IQ+ TA +L GY L
Sbjct: 1160 GVNHGPVIAGVIGARKPQYDIWGDTVNVASRMDSSGEPGKIQMREETA-AVLVKYGYNLE 1218
Query: 1073 SRGLTQIKGKGAMHTYWLLGKE 1094
RG+T++KGK M T++LL K+
Sbjct: 1219 LRGITKVKGKEPMKTFYLLHKK 1240
Score = 105 bits (253), Expect = 6e-21
Identities = 69/213 (32%), Positives = 107/213 (50%), Gaps = 8/213 (3%)
Query: 851 NIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPE 910
N VDSM + LEK +EL+ +++ K + N PR L + +
Sbjct: 399 NSVDSMIK-LEKEKQQQDELLVSCIPSNLVKEIKKDLQENMREPRPT-----LFHDLYVQ 452
Query: 911 EFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVV 970
+ VSI ++DIV FT LA+ TA ++V +LN+L+ FD ++ +++ +GD Y V
Sbjct: 453 RYHGVSILYADIVNFTPLASECTAAELVKMLNELFGRFDQLAKKSSCMRIKILGDCYYCV 512
Query: 971 GGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPR 1030
G+P + HA + M L +L VR + +RIG+HTG GV+GL +
Sbjct: 513 SGIPTADKKHAHNCVRMGLRMLDAIR--DVRENTGVDVDMRIGVHTGSVLCGVLGLRKWQ 570
Query: 1031 YCLFGDTVNTASRMESTGAAWRIQISSTTAEKL 1063
Y ++ D V A+ MES G R+ IS T + L
Sbjct: 571 YDVWSDDVTIANNMESGGVPGRVHISKQTLDCL 603
>UniRef50_A2DC46 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1572
Score = 112 bits (269), Expect = 7e-23
Identities = 69/227 (30%), Positives = 119/227 (52%), Gaps = 5/227 (2%)
Query: 868 EELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTA 927
E + E+ + D+ K K+E+LL ++LP+ + RL G +I+F DIV F+
Sbjct: 1324 ESEVIEKRKAADIAKAKSEKLLYQILPKDIVVRLNRGETDISFTIPSATIFFIDIVKFSV 1383
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGGLPQRTRDHAESVAT 986
A+ T +++ L+ ++ FD + +Y + K++ IGD YM GL Q D A
Sbjct: 1384 YASSLTPSEIMTNLSTVFAAFDQNVSKYDLITKIKLIGDVYMAAAGLFQGEEDDPTKHAD 1443
Query: 987 MALH--LLHLAGRFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDTVNTASR 1043
++ L + + ++ + +RIG+++ GP GV+G P + + GDT+N A+R
Sbjct: 1444 QSIKCCLDCIKSMDEINSNLESSIEVRIGVNSGGPLIGGVLGSDKPTFDIIGDTINVAAR 1503
Query: 1044 MESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
++ST RIQIS T + L+ Y + RG +KGKG T+++
Sbjct: 1504 LQSTDIPGRIQISEGT-KSLIDGLDYIIEERGEIFLKGKGNRKTFFV 1549
>UniRef50_UPI0000D55CA0 Cluster: PREDICTED: similar to CG9210-PA,
isoform A; n=2; Endopterygota|Rep: PREDICTED: similar to
CG9210-PA, isoform A - Tribolium castaneum
Length = 1370
Score = 111 bits (268), Expect = 9e-23
Identities = 75/242 (30%), Positives = 122/242 (50%), Gaps = 32/242 (13%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRV---------EPE--------------EFE 913
QL+ EKK E +++ ++P SVAE L+ +PE E
Sbjct: 279 QLESEKKLKENMIHSLMPSSVAEWLLSEEETFTRSDQRNSDPETNDIRSLFRPFNMNRME 338
Query: 914 EVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGL 973
VSI F+DIVGFT +A++ +A ++V++LN+L+ FD + + K+ T+GD Y V G
Sbjct: 339 NVSILFADIVGFTKMASKKSAEELVEILNNLFQRFDHLCKFHNCEKISTLGDCYYCVSGC 398
Query: 974 PQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCL 1033
P+ DHA+ M L ++ +F + +++R+G+HTG G+VG ++ +
Sbjct: 399 PEPRHDHAKCCVEMGLSMIQAIKQFDQE--KNEGVNMRVGVHTGTVLCGIVGTRRFKFDV 456
Query: 1034 FGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGK 1093
+ + V A+RMESTG + +S T E L L G + M TY++LG+
Sbjct: 457 WSNDVTLANRMESTGKPGMVHVSEKTCEFL---QDMYLLEEGEPVL----GMKTYFILGR 509
Query: 1094 EG 1095
G
Sbjct: 510 TG 511
Score = 99.1 bits (236), Expect = 7e-19
Identities = 75/228 (32%), Positives = 112/228 (49%), Gaps = 16/228 (7%)
Query: 882 KKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARST--AVQVVD 939
K + + L+ ++P VAE+L ++ E F++V I F+ IV F + S + +
Sbjct: 1143 KTQADYLIYNIVPEHVAEQLKKNAKYS-ENFKDVGIIFASIVNFNEMYDESYLGGKEYLR 1201
Query: 940 LLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTR-------DHAESVATMAL 989
+LN+L FD +++ V K++TIG +M GL TR +H ++ AL
Sbjct: 1202 VLNELIADFDELLDRPEFASVEKIKTIGSTFMAASGLNSTTRRNQKDPNEHLYALMDFAL 1261
Query: 990 HLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
+ ++ F R L + L LRIG + G A V+G T Y ++GD VN ASRM+STG
Sbjct: 1262 EMQNVITDFN-RDLLEFNLILRIGYNFGEVTAAVIGNTKLYYDIWGDAVNIASRMDSTGV 1320
Query: 1050 AWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEGFD 1097
IQI + L Y R RG +KGK M Y L K+ D
Sbjct: 1321 NGCIQIGENCLQVLETR--YVFRPRGSVYVKGKDNMSVYLLERKKTDD 1366
>UniRef50_Q1VN94 Cluster: Two-component hybrid sensor and regulator;
n=1; Psychroflexus torquis ATCC 700755|Rep: Two-component
hybrid sensor and regulator - Psychroflexus torquis ATCC
700755
Length = 349
Score = 111 bits (268), Expect = 9e-23
Identities = 63/216 (29%), Positives = 116/216 (53%), Gaps = 8/216 (3%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQ 936
+++ +KK+T+ L ++LP +AE L V P ++E+++I D+VGFTA +
Sbjct: 139 KVEADKKRTQAFLKQILPEKIAEELNSSGLVRPRKYEDIAILVCDLVGFTAFCESNPPEN 198
Query: 937 VVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAG 996
VVD L +++ F++ IE++ + K++T+GDA + GGL + + S + A++L +A
Sbjct: 199 VVDNLQEIFEKFESEIEKFGLEKIKTVGDAILATGGLTRSLDNQVLSASRCAINLKKIA- 257
Query: 997 RFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQIS 1056
+ P+ +H IG+H+GP AG++G ++ + G VNTA + I IS
Sbjct: 258 ---IESDPNWAIH--IGIHSGPLVAGLIGKKSFQFDVLGGNVNTAFNICDRTEPNEILIS 312
Query: 1057 STTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
+ + ++S+GL ++K + LLG
Sbjct: 313 NEA--WMSVRSDVDVKSKGLMKLKSDNDIEVLQLLG 346
>UniRef50_O96306 Cluster: Adenylyl cyclase isoform DAC39E; n=7;
Diptera|Rep: Adenylyl cyclase isoform DAC39E - Drosophila
melanogaster (Fruit fly)
Length = 1167
Score = 111 bits (268), Expect = 9e-23
Identities = 62/191 (32%), Positives = 111/191 (58%), Gaps = 11/191 (5%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLM--LGS-------RVEPEEFEEVSIYFSDIVGFTAL 928
++ + + E+LL +LP+ VA ++ LGS ++ E VSI ++DIVGFTA+
Sbjct: 256 IEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSILYADIVGFTAI 315
Query: 929 AARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMA 988
++ +A +V +LN+L+ FD E+Y+ +++ +GD Y + G P DHA M
Sbjct: 316 SSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMG 375
Query: 989 LHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
L ++ A ++ V+ ++P+ +R+G+HTG AG++G ++ ++ V A++MES+G
Sbjct: 376 LSMVK-AIKY-VQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSG 433
Query: 1049 AAWRIQISSTT 1059
A R+ IS T
Sbjct: 434 KAGRVHISDKT 444
Score = 111 bits (268), Expect = 9e-23
Identities = 75/244 (30%), Positives = 129/244 (52%), Gaps = 22/244 (9%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR-----VEPEEFEEVSIYFSDIVGF 925
+ E+ E + +++ E L+ +LP VAE M ++ + + + EV + F+ + F
Sbjct: 851 VAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNF 910
Query: 926 TALAARSTA----VQVVDLLNDLYTTFDAAIE--QYR-VYKVETIGDAYMVVGGLP-QRT 977
+ + T ++ + LN++ + FDA +E Q++ + K++TIG YM G+ QRT
Sbjct: 911 SDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINLQRT 970
Query: 978 RDHAESVATMALHLLHLAG-----RFRVRHLPDTPLH---LRIGLHTGPCCAGVVGLTMP 1029
+ + HL L + ++ + + + L++G++ GP AGV+G P
Sbjct: 971 VRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKP 1030
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYW 1089
Y ++G+TVN ASRMESTG A IQ++ T +L GY RGL +KGKG + T++
Sbjct: 1031 HYDIWGNTVNVASRMESTGKAGAIQVTEETC-NILRLFGYTFLQRGLVAVKGKGQLMTFY 1089
Query: 1090 LLGK 1093
L GK
Sbjct: 1090 LQGK 1093
>UniRef50_A2FSM3 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1416
Score = 111 bits (268), Expect = 9e-23
Identities = 71/251 (28%), Positives = 128/251 (50%), Gaps = 11/251 (4%)
Query: 847 GRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR 906
G K N D+ + N E I++R + + K K+E+LL ++LP+ + RL G +
Sbjct: 1149 GMKDNENDTEINSIVFILTNETEEIKKRNDA-EQAKAKSEKLLYQILPKDIVVRLNRGEK 1207
Query: 907 VEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYR-VYKVETIGD 965
+I+F DIV F+ +A + +++ L+ ++ TFD + +Y+ + K++ IGD
Sbjct: 1208 DISFSIPIATIFFIDIVKFSNYSATLSPSEIMQNLSLVFATFDKNVSKYQSITKIKLIGD 1267
Query: 966 AYMVVGGL-----PQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT-GPC 1019
YM GL + +DHA L + + ++ L +R+G+++ GP
Sbjct: 1268 VYMAAAGLFNNADEKTAKDHATEAVNCCLQC--IKSMTDINTNLESSLEVRVGVNSGGPL 1325
Query: 1020 CAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQI 1079
GV+G P + + GD +N A+R++ST +QIS T + L+ + + + RG +
Sbjct: 1326 IGGVLGTDKPTFDIIGDPINVAARLQSTDIPGNVQISEET-KNLIESSDFIIEERGEVYL 1384
Query: 1080 KGKGAMHTYWL 1090
KGKG TY++
Sbjct: 1385 KGKGNRKTYFV 1395
>UniRef50_A0C5Y1 Cluster: Chromosome undetermined scaffold_151, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_151, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2641
Score = 111 bits (268), Expect = 9e-23
Identities = 61/191 (31%), Positives = 110/191 (57%), Gaps = 6/191 (3%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP--EEFEEVSIYFSDIVGFTALAARSTAV 935
L+++K ++E L+ +LP + ++ + ++ E E+ EE ++ F+DI GFT +++
Sbjct: 2399 LEIKKNQSENLVKYLLPNHILKQFLSNNQREVLVEQLEEATLLFADIAGFTEYSSKVEPE 2458
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD---HAESVATMALHLL 992
QVV++L +L+T FD YK+ TIGD Y+ VG + R R+ A++V + ++
Sbjct: 2459 QVVNMLRNLFTEFDKKCLTQNTYKLYTIGDCYVAVGIIDIRQRNPAQEAKNVVELGFGMI 2518
Query: 993 HLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWR 1052
+ R + + L +RIG+HTG AG++G + RY ++G V +++MES G R
Sbjct: 2519 EIIRNVR-QIIGFDGLDMRIGIHTGKVIAGILGTEIVRYDVYGADVMISNKMESNGEKGR 2577
Query: 1053 IQISSTTAEKL 1063
+Q+S T + L
Sbjct: 2578 VQVSEETKQLL 2588
Score = 99 bits (238), Expect = 4e-19
Identities = 81/264 (30%), Positives = 130/264 (49%), Gaps = 12/264 (4%)
Query: 833 DFNRLHDVFRQMQRGRKINIVDSMFEMLEKYSN-NLEELIRERTEQLDMEKKKTEQLLNR 891
+F+++ + + G + I S+ M +Y LE L+ E K +L+
Sbjct: 1716 EFSQVQITYYSLINGEVVVIATSILFMALQYKLIRLEREDFMLDVTLNQETSKMTNVLSI 1775
Query: 892 MLPRSVAERLMLGSRVEPEEFE-EVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDA 950
+LP+ + +R+ E E + VSI F DI GF L +V +L+ L+ +FD
Sbjct: 1776 LLPKFIRDRINAKGMFEISENQGNVSILFCDICGFDDLITVEKE-NIVKILDGLFRSFDQ 1834
Query: 951 AIEQYRVYKVETIGDAYMVVGGLP---QRTRDHAESVATMALHL-LHLAGRFR-VRHLPD 1005
Q + KVET+G YM GGL Q T+ + ++ A+ L L + R V++
Sbjct: 1835 LCAQNGMQKVETVGKTYMAAGGLKAVDQGTKFYNQNCVKRAVQLSLEMMDHTRKVKYGQI 1894
Query: 1006 TPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLA 1065
L ++IG+H G AGV+G P++ L GDTVNT SR+ STG ++ +S+ E L
Sbjct: 1895 GHLTIKIGIHYGRVIAGVIGHHKPQFSLIGDTVNTTSRVCSTGQDGQVTLSN---EAYLE 1951
Query: 1066 AGGYKLR-SRGLTQIKGKGAMHTY 1088
+L+ ++ KGKG + TY
Sbjct: 1952 INMPELQFTQRKVAAKGKGELITY 1975
>UniRef50_A2FW09 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=12; Eukaryota|Rep: Adenylate
and Guanylate cyclase catalytic domain containing protein
- Trichomonas vaginalis G3
Length = 1567
Score = 111 bits (266), Expect = 2e-22
Identities = 71/242 (29%), Positives = 126/242 (52%), Gaps = 10/242 (4%)
Query: 854 DSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFE 913
D++ ++ +N LEE+ ++ ++ + K K+E+LL ++LP+++ RL G
Sbjct: 1311 DNLNSIVFILTNELEEI--QKRKEAEEAKAKSEKLLYQILPKNIVVRLNGGETDISFTIN 1368
Query: 914 EVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGG 972
+I+F DIV F+ A+ T +++ L+ ++ TFD+ + +Y + K++ IGD YM G
Sbjct: 1369 SATIFFIDIVKFSNYASLLTPSEIMSNLSLVFATFDSIVSKYTTITKIKLIGDVYMAAAG 1428
Query: 973 L---PQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTM 1028
L + HAE L + + + L +RIG ++ GP GV+G
Sbjct: 1429 LFMEEDSPQKHAEEAVRCCLEC--SKSMDDINYKLNASLEVRIGCNSGGPLIGGVLGTDK 1486
Query: 1029 PRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
P + + GD +N A+R++ST +QIS T E L+ + + RG +KGKG TY
Sbjct: 1487 PTFDIIGDPINVAARLQSTDIPGNVQISGNTKE-LIQNLDFVIEERGEIYLKGKGNRMTY 1545
Query: 1089 WL 1090
++
Sbjct: 1546 FV 1547
>UniRef50_A2FG49 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=4; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1585
Score = 111 bits (266), Expect = 2e-22
Identities = 71/233 (30%), Positives = 119/233 (51%), Gaps = 11/233 (4%)
Query: 864 SNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIV 923
+N EE+ ++ + + K K+E+LL ++LP+ + RL G + +I+F DIV
Sbjct: 1336 TNETEEI--KKRQAAEEAKAKSEKLLYQILPKDIVVRLNRGEKDISFTIPSATIFFIDIV 1393
Query: 924 GFTALAARSTAVQVVDLLNDLYTTFDAAIEQYR-VYKVETIGDAYMVVGGLPQRTRD--- 979
F+ AA T +++ L+ ++ TFD + +Y + K++ IGD YM GL Q D
Sbjct: 1394 KFSEYAALLTPTEIMANLSLVFATFDNIVAEYESITKIKLIGDVYMAAAGLFQDPEDPSL 1453
Query: 980 -HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDT 1037
HAE + ++ + L +RIG +T GP GV+G P + + GD
Sbjct: 1454 KHAEDAVRCCIACSKAMEEINMK--LNASLEVRIGCNTGGPLLGGVLGTDKPTFDIIGDP 1511
Query: 1038 VNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
+N A+R++ST +QIS T E + +++ RG +KGKG TY++
Sbjct: 1512 INVAARLQSTDIPGNVQISQDTKEAIKDL-DFEVEERGEIYLKGKGNRITYFV 1563
>UniRef50_A2DFE4 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=5; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1681
Score = 111 bits (266), Expect = 2e-22
Identities = 70/225 (31%), Positives = 115/225 (51%), Gaps = 8/225 (3%)
Query: 869 ELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTAL 928
E +R++ E +++ KKK++ LL ++LP + R+ G + S+ F DI F+
Sbjct: 1448 EEMRQK-EAVEVAKKKSDDLLLKILPPDIIRRINKGEKDITMVVPSASVIFIDICQFSTY 1506
Query: 929 AARSTAVQVVDLLNDLYTTFDAAIEQYR-VYKVETIGDAYMVVGGL---PQRTRDHAESV 984
A +A Q + LN ++T +D + + K++ IGD YM GL + + HA
Sbjct: 1507 MATLSAQQCMSNLNAVFTAYDKILADLPLITKIKLIGDDYMAAAGLFSPDEPPKSHAIQT 1566
Query: 985 ATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTG-PCCAGVVGLTMPRYCLFGDTVNTASR 1043
T L +L + + L +RIG+++G P AGV+G P + + GDT+N A+R
Sbjct: 1567 ITFGLRVLDAIEELNEQL--NASLMVRIGVNSGGPIIAGVLGTDKPLFDIIGDTINVAAR 1624
Query: 1044 MESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
++ST +QIS T E + G + + RG +KGKG TY
Sbjct: 1625 LQSTDIPGNVQISKGTYEIVAGEGKFHIEERGEIYLKGKGNQMTY 1669
>UniRef50_UPI0000D56083 Cluster: PREDICTED: similar to CG10564-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG10564-PA - Tribolium castaneum
Length = 1551
Score = 110 bits (265), Expect = 2e-22
Identities = 78/256 (30%), Positives = 139/256 (54%), Gaps = 22/256 (8%)
Query: 860 LEKYSNNLEELIRERTEQL--DMEKKK--TEQLLNRMLPRSVAERLMLGSRVEPEEF--- 912
L + ++ L+ L +++ E+ DME+ + QLL +LP VA+ + R E +
Sbjct: 1055 LVEVTSRLDFLWKQQAERELNDMEETRHTNTQLLKNILPDHVAQHFLSNERNSEELYSQS 1114
Query: 913 -EEVSIYFSDIVGFTALAAR--STAVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDA 966
EEV + F+ I FT + + ++ + LLN++ FD +++ R + K++T+
Sbjct: 1115 REEVGVLFASIPNFTEFYSEDINKGLECIRLLNEIIADFDELLDEERFSMIEKIKTVSAT 1174
Query: 967 --YMVVGGLPQRTRD--HAESVATM-ALHLLHLAGRFRVRHLPDTPLH---LRIGLHTGP 1018
YM GL +D + +S + AL +A R ++ + + LR+G+ G
Sbjct: 1175 ATYMAASGLNPTHKDALNTDSPEHLCALIDFAIAMRQKLDEINKESFNNFGLRVGVSCGS 1234
Query: 1019 CCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQ 1078
GV+G P + ++G+TVN ASRM+STG +IQ+ TA+ LL GY+++ RG+ +
Sbjct: 1235 LVCGVIGARKPVFDIWGNTVNEASRMDSTGVIGQIQVPKYTAQ-LLGVRGYEVKKRGIIE 1293
Query: 1079 IKGKGAMHTYWLLGKE 1094
+KGKG M TY+++G++
Sbjct: 1294 VKGKGQMETYFVMGRQ 1309
Score = 110 bits (264), Expect = 3e-22
Identities = 72/201 (35%), Positives = 104/201 (51%), Gaps = 17/201 (8%)
Query: 881 EKKKTEQLLNRMLPRSVA-------ERLMLGSRVEPEEF--------EEVSIYFSDIVGF 925
E K E+LL +LP VA ER G +P +F E VSI F+DI GF
Sbjct: 341 ENDKQEKLLLSVLPDFVAKEMIRDIEREERGGVFQPHQFHKIYIHRYENVSILFADIKGF 400
Query: 926 TALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVA 985
TALA++ +A ++V +LN+L+ FD + +++ +GD Y V GLP DHA
Sbjct: 401 TALASQCSAQELVRILNELFARFDKLAAENHCLRIKLLGDCYYCVSGLPTPRSDHAHCSV 460
Query: 986 TMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRME 1045
M LH++ R + D L++RIG+H+G GV+GL ++ +F V A+ ME
Sbjct: 461 EMGLHMIKAIRDTRTKTQVD--LNMRIGIHSGSVLCGVLGLRKWQFDIFSYDVRLANHME 518
Query: 1046 STGAAWRIQISSTTAEKLLAA 1066
S G R+ IS T + L A
Sbjct: 519 SGGIPGRVHISEATYQCLNGA 539
>UniRef50_Q23TD7 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Tetrahymena thermophila
SB210|Rep: Adenylate and Guanylate cyclase catalytic
domain containing protein - Tetrahymena thermophila SB210
Length = 2945
Score = 110 bits (264), Expect = 3e-22
Identities = 59/192 (30%), Positives = 108/192 (56%), Gaps = 7/192 (3%)
Query: 879 DMEKKKTEQLLNRMLPRSVAERLMLGSRVEPE---EFEEVSIYFSDIVGFTALAARSTAV 935
+++K + + LL ++P+ + + + + E E+V++ F+DI GFT+ ++
Sbjct: 2703 EIKKSEKDNLLKYLVPKHILTQFLQNKKQYKEISESLEKVTLLFADIAGFTSYSSNKQPS 2762
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAE---SVATMALHLL 992
+VV +L +L+T+FD +++VYKV TIGD Y+V+G + ++ R + E +V M ++
Sbjct: 2763 EVVKMLRNLFTSFDQLCLKHKVYKVYTIGDCYVVIGIVDKQNRQYQEECKNVIQMGFSMI 2822
Query: 993 HLAGRFRVRHLPDTPLHLRIGLHTG-PCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAW 1051
+ + H +++RIG+H G G++G + RY +FG V A++MES G
Sbjct: 2823 QVIENIKREHEDFKSVNMRIGIHLGEKVLGGIIGTNIVRYDIFGKDVVIANKMESNGQLG 2882
Query: 1052 RIQISSTTAEKL 1063
RI IS T + L
Sbjct: 2883 RINISEDTKKFL 2894
Score = 79.8 bits (188), Expect = 4e-13
Identities = 63/225 (28%), Positives = 102/225 (45%), Gaps = 14/225 (6%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFE-EVSIYFSDIVGFTALAARSTAV 935
++ E+ + + +L +LP V R EE + EV+I F DI F ++
Sbjct: 2040 RIKYEENEVDHVLANLLPPFVRTRFNSSGNASIEEDQGEVAILFLDICDFDSIL-NEEQT 2098
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGL----PQRTRDHAESVATMALHL 991
+++ +++LY FD +Y V K+ET+G YM GL ++ R +
Sbjct: 2099 KLIKWIDNLYRQFDKICVEYGVQKIETVGKIYMACAGLKLTKEEKLRQQKMLLTENETER 2158
Query: 992 LHLAG---RFRVRHL---PDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRME 1045
L LA + + + + ++IG+H G AGV+G P++ L GDTVNTASR+
Sbjct: 2159 LVLAAQEMQIKAKQYFWGNNQQTDVKIGIHYGKVIAGVIGAHKPQFSLIGDTVNTASRVC 2218
Query: 1046 STGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
S RI +S +L L + KGKG + + L
Sbjct: 2219 SKCKEKRISLSYEAHRRLGKTEWLFLEKE--VEAKGKGILKIFSL 2261
>UniRef50_UPI00006CFA91 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2815
Score = 109 bits (263), Expect = 4e-22
Identities = 69/209 (33%), Positives = 110/209 (52%), Gaps = 12/209 (5%)
Query: 865 NNLEELIRERTEQLDMEKKKTE--QLLNRMLPRSVAERLMLGSRVE-P---EEFEEVSIY 918
N+++ +R +E KK E LL +LP + + + + E P EE +V++
Sbjct: 2582 NHMQNEVRNFNNLKTLESKKDELDSLLKNLLPAHILDTFLNSMKKEIPLICEELHDVTLL 2641
Query: 919 FSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTR 978
F+DI GFT ++ + + VV++L L+T FD VYK+ TIGD Y+ G + R
Sbjct: 2642 FADIAGFTKYSSTTDPIVVVNMLRRLFTDFDDHCLNQNVYKLYTIGDCYVCFGLTNKNER 2701
Query: 979 D---HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
+ A +V A ++ + VR D L +RIG+HTG G+VG + RY ++G
Sbjct: 2702 NPAQEAHNVVRFAFDMIRIIE--NVRQYTDCNLQMRIGVHTGKLYGGIVGTEIVRYDIYG 2759
Query: 1036 DTVNTASRMESTGAAWRIQISSTTAEKLL 1064
V A++MES G + + +S TT +KLL
Sbjct: 2760 QDVIIANKMESNGESGHVMVSETT-KKLL 2787
Score = 91.9 bits (218), Expect = 1e-16
Identities = 60/205 (29%), Positives = 100/205 (48%), Gaps = 15/205 (7%)
Query: 884 KTEQLLNRMLPRSVAERLML---GSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDL 940
K + +L+ +LP+ + E++ G E+ +EV I F DI F + + V +
Sbjct: 1874 KVKDILSILLPKFIREKIETMKQGQYRVAEKQDEVIIVFCDICNFDDIIFNEK-INTVKI 1932
Query: 941 LNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ---------RTRD--HAESVATMAL 989
L+ LY FD A +Q + K+ET+G Y+ G+ R +D A+ A
Sbjct: 1933 LDKLYRQFDLACQQNGLQKIETVGKTYLAAAGISDVEKLLKAEGRLQDVSPAKRALQFAF 1992
Query: 990 HLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
L + ++ + + +++G+H GP +GV+G P++ L GDTVNT SR+ STG
Sbjct: 1993 DLQRIVKSKQLYLASNKKIIIKVGIHLGPAISGVIGYHKPQFSLIGDTVNTTSRVCSTGL 2052
Query: 1050 AWRIQISSTTAEKLLAAGGYKLRSR 1074
+ I IS +K+ YK + R
Sbjct: 2053 SDHIIISKEVYDKVYQLSQYKFQQR 2077
>UniRef50_A2F3K7 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1588
Score = 109 bits (263), Expect = 4e-22
Identities = 75/258 (29%), Positives = 126/258 (48%), Gaps = 19/258 (7%)
Query: 848 RKINIVDSMFEMLEKYSNNLEELI---------RERTEQLDMEKKKTEQLLNRMLPRSVA 898
+ +N+ S+ M Y++NL + E+ Q + EK K+E LL ++LPR +
Sbjct: 1314 KSLNVKCSIIGMKNSYNDNLNSFVFILKDTTKLEEQKRQAENEKMKSENLLYQILPRDIV 1373
Query: 899 ERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVY 958
++ + +I F DI F+ T ++ L+ ++ D +++Y +
Sbjct: 1374 LQINKNIKEISFNVNSATICFIDINKFSEYTTNLTPNNIMSNLSYYFSVLDQTLKEYPLL 1433
Query: 959 -KVETIGDAYMVVGGLPQRT---RDHAESVATMALHLL-HLAGRFRVRHLPDTPLHLRIG 1013
K++ IGD YM GG+ HAE + +L HL + D+ L +RIG
Sbjct: 1434 IKIKLIGDIYMAAGGIFNNDVGPEVHAEQMILFCFDVLYHLE---EINKKLDSNLQIRIG 1490
Query: 1014 LHTG-PCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLR 1072
++TG P AGV+G P + + GD +N A+R++ST ++ IS T E L+ Y +
Sbjct: 1491 INTGGPLIAGVLGTDKPLFDIIGDPINVAARLQSTSDVNKVHISGDTFE-LVKGLNYDIT 1549
Query: 1073 SRGLTQIKGKGAMHTYWL 1090
RG T +KGKG TY++
Sbjct: 1550 KRGETFLKGKGKQITYYI 1567
>UniRef50_Q4STI6 Cluster: Chromosome undetermined SCAF14199, whole
genome shotgun sequence; n=3; Tetraodon nigroviridis|Rep:
Chromosome undetermined SCAF14199, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 982
Score = 109 bits (262), Expect = 5e-22
Identities = 69/218 (31%), Positives = 113/218 (51%), Gaps = 18/218 (8%)
Query: 862 KYSNNLEELIRERTEQLDMEKKKTEQ--LLNRMLPRSVAERLMLGSRVEPEE-------- 911
KY E R +L +E++ T+Q LL +LP+ +A+ ++ G + + ++
Sbjct: 248 KYRMAFLEARRSLEVKLTLEEQSTQQEELLLSILPKHIADEMLQGMKNQAQQQEVQQQFN 307
Query: 912 ------FEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGD 965
E VSI F+DIVGFT L++ +A ++V LLN+L+ FD +Y +++ +GD
Sbjct: 308 TMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGD 367
Query: 966 AYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVG 1025
Y + GLP DHA M L ++ VR T + +R+G+HTG GV+G
Sbjct: 368 CYYCICGLPDFRDDHAACSIMMGLAMVDAIS--YVREKTRTEVDMRVGVHTGTVLGGVLG 425
Query: 1026 LTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKL 1063
++ ++ V A++MES G R+ IS TT + L
Sbjct: 426 QKRWQFDVWSTDVTLANKMESGGIPGRVHISQTTKDSL 463
Score = 95.5 bits (227), Expect = 8e-18
Identities = 73/249 (29%), Positives = 128/249 (51%), Gaps = 28/249 (11%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE-----FEEVSIYFSDIVGF 925
+ ++ E++ ++ E L+ MLP VA+ LG++ EE + ++ + F+ I F
Sbjct: 714 VHDQKEKVFEMRRCNEALVTNMLPEHVAKHF-LGTKKRDEELYSQSYSQIGVMFASIPNF 772
Query: 926 ----TALAARSTAVQVVDLLNDLYTTFDAAI--EQYR-VYKVETIGDAYMVVGGL-PQ-R 976
T + ++ + +LN++ + FD+ + E++R + K++TIG YM GL P+
Sbjct: 773 SDFYTEEGINNGGIECLRILNEIISDFDSLLDKEEFRSITKIKTIGSTYMAASGLTPECH 832
Query: 977 TRDHAESV-ATMALHLLHLAG--------RFRVRHLPDTPLH---LRIGLHTGPCCAGVV 1024
T + +S + H HL+ + + +L + LRIG++ G AGV+
Sbjct: 833 TNGYNKSEDQPLVEHWRHLSDLADFALSMKVTLNNLNKQSFNNFMLRIGINKGGVLAGVI 892
Query: 1025 GLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGA 1084
G P Y ++G+TVN ASRMESTG IQ+ + +L G+ RG +KGKG
Sbjct: 893 GARKPHYDIWGNTVNVASRMESTGVMGNIQVVEDCYD-ILKEYGFHFVRRGPIFVKGKGE 951
Query: 1085 MHTYWLLGK 1093
+ T+++ GK
Sbjct: 952 LLTFFMKGK 960
>UniRef50_A2GA06 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1568
Score = 109 bits (262), Expect = 5e-22
Identities = 68/232 (29%), Positives = 122/232 (52%), Gaps = 10/232 (4%)
Query: 864 SNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIV 923
+N L+E ++ + + K K+E+LL ++LP+ + RL G + S++F DIV
Sbjct: 1321 TNILDET--KKRKAAETAKAKSEKLLYQILPKDIVLRLNRGEKDISFNINHSSVFFIDIV 1378
Query: 924 GFTALAARSTAVQVVDLLNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGGL---PQRTRD 979
F+ ++ + +++ L+ ++ FD + Q+ V K++ IGD YM G+ +
Sbjct: 1379 KFSQYSSHLSPSEIMQNLSLVFNNFDKIVVQFPLVNKIKLIGDVYMAASGIFHQDNSKEE 1438
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDTV 1038
HAES L L + ++ L LRIG+++ GP GV+G P + + GD +
Sbjct: 1439 HAESAVKCCLKCLKSMEDINTK--LNSSLELRIGINSGGPLIGGVLGADKPTFDIIGDPI 1496
Query: 1039 NTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
N A+R++S+ R+QIS + E L+ + + + RG +KGKG TY++
Sbjct: 1497 NVAARLQSSDIPGRVQISQSIKE-LIKSNDFTIEERGEVFLKGKGNQITYFI 1547
>UniRef50_A2EII5 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1612
Score = 109 bits (262), Expect = 5e-22
Identities = 87/314 (27%), Positives = 151/314 (48%), Gaps = 16/314 (5%)
Query: 784 MLSFTPEEIIDKLCRPPPLIRPSVSMGAAPPEAVSVMRQCWSEAPDLRP--DFNRLHDVF 841
+L +TPE+++ +L + LI + E + + + D D +L V
Sbjct: 1205 LLGYTPEQVLGQLVQTF-LIPKDMDDFTVKLEQMKNNQSSYFIEEDYTAIADNEKLIPVH 1263
Query: 842 RQMQRGRKINIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERL 901
+ +K N+V+S +++ N+E L ++ +Q + K K+E+LL ++LPR + +L
Sbjct: 1264 LTLIGMKKENVVNSFVVLMQ----NIENLTNQK-KQAEEAKMKSEKLLYQILPRDIVLKL 1318
Query: 902 MLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQY-RVYKV 960
G + +I F DI F+ + T ++ L+ + D +Y + K+
Sbjct: 1319 NKGEKDISFVVPSATIIFIDINKFSEYSKNLTPQAIMSNLSYYFAQLDRVAGKYGMIQKI 1378
Query: 961 ETIGDAYMVVGGL---PQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTG 1017
+ IGD YM GL HAE +L L + HL D+ L +RIG+++G
Sbjct: 1379 KLIGDIYMAASGLFNPDSPPESHAEQAVQFSLACLDALDDVNI-HL-DSHLEIRIGINSG 1436
Query: 1018 -PCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGL 1076
P AGV+G P + + GD +N A+R++ST R+ +S T L+ Y++ RG
Sbjct: 1437 GPIIAGVLGTDKPVFDIIGDPINVAARLQSTSEVNRVHVSQATL-SLINNITYEVTPRGE 1495
Query: 1077 TQIKGKGAMHTYWL 1090
T +KGKG TY++
Sbjct: 1496 TFLKGKGKQLTYYI 1509
>UniRef50_A0CKZ5 Cluster: Chromosome undetermined scaffold_20, whole
genome shotgun sequence; n=4; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_20, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2620
Score = 109 bits (262), Expect = 5e-22
Identities = 66/220 (30%), Positives = 110/220 (50%), Gaps = 7/220 (3%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQ 936
+L E+KK +L ++PR + ER+ G ++ +VS+ F DI F + + +
Sbjct: 1613 RLSKEQKKINSVLGLLMPRFIQERMNKGQIQISQDQGDVSVLFCDIYQFDKVI-KDQQEK 1671
Query: 937 VVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQR----TRDHAESVATMALHLL 992
+++ L+ +Y FD + Y + K+ET+G YM GGL + +A S + +
Sbjct: 1672 IIEFLDTIYRAFDQLCQNYDLQKIETVGKTYMAAGGLKDYDVVINQKNANSTSRALETAI 1731
Query: 993 HLAGRFRVRHLPDTP-LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAW 1051
+ + D + L+IG+H G AGV+G+ P++ L GDTVNT SR+ STG A
Sbjct: 1732 QMMETVKTMKYGDNQDVQLKIGIHYGRVIAGVIGVHKPQFSLIGDTVNTTSRVCSTGEAG 1791
Query: 1052 RIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLL 1091
I +S + Y+ + + KGKG + TY L+
Sbjct: 1792 FITLSEAAYLHVKDNTKYQFEKKSVA-AKGKGMIETYKLI 1830
Score = 102 bits (245), Expect = 5e-20
Identities = 59/190 (31%), Positives = 100/190 (52%), Gaps = 8/190 (4%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEF----EEVSIYFSDIVGFTALAARS 932
QL + K E +L ++P RL+ + + F E ++ F+DI GFT ++
Sbjct: 2388 QLSTQIAKYENMLQYLMPPHALRRLLNPDQENTDTFMDVLENATVLFADIAGFTKYSSSV 2447
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD---HAESVATMAL 989
VVD+L +L++ FD ++ +YK+ TIGD Y+ +G L + RD A+ V
Sbjct: 2448 EPETVVDMLRNLFSNFDQYCQKAEIYKLFTIGDCYVCMGVLDCKKRDPAGEAQKVLAFGF 2507
Query: 990 HLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
++ + ++ + L++RIG+HTG GVVG + RY ++G+ V A+ MES+G
Sbjct: 2508 SMIEIINHYK-KDPQYQHLNMRIGVHTGRVLGGVVGTDVVRYDIYGEDVTIANLMESSGQ 2566
Query: 1050 AWRIQISSTT 1059
+I +S T
Sbjct: 2567 EGKILVSEIT 2576
>UniRef50_A0C7P7 Cluster: Chromosome undetermined scaffold_156, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_156, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 2354
Score = 109 bits (262), Expect = 5e-22
Identities = 56/191 (29%), Positives = 103/191 (53%), Gaps = 4/191 (2%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAV 935
+QL ++++ ++++ +LP + ++ P+ FE +I ++DI GFT + A
Sbjct: 2130 DQLLQQQQEQNKIISHLLPSHILQQYFKEQDTIPDVFENATILYADIAGFTKYSTSVDAQ 2189
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT---RDHAESVATMALHLL 992
QV+ +L+ L+ FD A + VYK+ +IGD+Y+V+G L + A +V + LL
Sbjct: 2190 QVLQMLSSLFNKFDVACTENNVYKLYSIGDSYVVIGVLDANNGIREEEAYNVVNLGFQLL 2249
Query: 993 HLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWR 1052
+ + +++ +++RIG+HTG G+VG + RY ++G V A +ME R
Sbjct: 2250 DIVNLLK-KNIQYPDINMRIGIHTGNIIGGIVGTDIVRYDIYGSDVAIAKKMEQNSQIGR 2308
Query: 1053 IQISSTTAEKL 1063
I +S T + L
Sbjct: 2309 IMVSEDTMKFL 2319
Score = 97.1 bits (231), Expect = 3e-18
Identities = 55/189 (29%), Positives = 98/189 (51%), Gaps = 10/189 (5%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAV 935
EQL+ E+KK L+ ++PR + ER+ G E+ V+I F +I F + S V
Sbjct: 1487 EQLEKEQKKLNDALSILMPRFIKERMARGYIQIQEDQGPVTILFCEICDFDDII-ESEKV 1545
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGL------PQRTRDHAESVATMAL 989
++ L+ +Y TFD QY + K+ET+G Y+ GL +++++ + + A+
Sbjct: 1546 SIISFLDSIYRTFDTICNQYNIQKIETVGQIYVCASGLKDYDIIDKQSKNSTQKMIECAI 1605
Query: 990 HLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
++ + + D + ++IG++ G AGV+G P++ L GDTVNT SR +
Sbjct: 1606 AMMESTNNLKYQ---DKQIVIKIGINYGNVMAGVIGQHKPQFSLIGDTVNTTSRACTVCE 1662
Query: 1050 AWRIQISST 1058
+I ++ T
Sbjct: 1663 PGKISLTET 1671
>UniRef50_Q19523 Cluster: Putative uncharacterized protein acy-1; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein
acy-1 - Caenorhabditis elegans
Length = 1253
Score = 109 bits (261), Expect = 6e-22
Identities = 76/237 (32%), Positives = 122/237 (51%), Gaps = 17/237 (7%)
Query: 872 RERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAAR 931
R TE++ + + + + LLN ++P E L ++ E E V + F+ I + +
Sbjct: 1006 RRDTERMQIVRDQADWLLNNVIPAHAVESLKTDTKYS-ENHETVGVLFASITNWNDMYEE 1064
Query: 932 ST--AVQVVDLLNDLYTTFDAAIEQ---YRVYKVETIGDAYMVVGGL-PQRTR------D 979
+ + + +LN++ FD +++ + K++TIG AYM GL P+R + +
Sbjct: 1065 NFEGGREFLRVLNEVIGDFDELLDRPDFTHIEKIKTIGPAYMAASGLNPERKKNMLHPKE 1124
Query: 980 HAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN 1039
H + AL + H+ F L + ++GL+ GP AGV+G T Y ++GDTVN
Sbjct: 1125 HLYQMVDFALAVQHVLSVFN-EDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVN 1183
Query: 1040 TASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKG-KGAMHTYWLLGKEG 1095
ASRM STG RIQ+S T E LL Y+ R ++KG G M TY L+G++G
Sbjct: 1184 IASRMYSTGVLNRIQVSQHTREYLL--DRYEFEFRDHIEVKGIDGGMDTYLLVGRKG 1238
Score = 104 bits (250), Expect = 1e-20
Identities = 53/149 (35%), Positives = 85/149 (57%), Gaps = 2/149 (1%)
Query: 915 VSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLP 974
VSI F+DI GFT +++ +A ++V+LLNDL+ FD + K+ T+GD Y V G P
Sbjct: 318 VSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEKISTLGDCYYCVAGCP 377
Query: 975 QRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLF 1034
+ DHA M L ++ +F + +++R+G+HTG G+VG ++ +F
Sbjct: 378 EPCDDHACRTVEMGLDMIVAIRQFDIDR--GQEVNMRVGIHTGKVMCGMVGTKRFKFDVF 435
Query: 1035 GDTVNTASRMESTGAAWRIQISSTTAEKL 1063
+ V A+ MES+G A R+ +S TA+ L
Sbjct: 436 SNDVTLANEMESSGVAGRVHVSEATAKLL 464
>UniRef50_Q0C7B2 Cluster: Adenylate cyclase; n=2; Culicidae|Rep:
Adenylate cyclase - Aedes aegypti (Yellowfever mosquito)
Length = 1400
Score = 109 bits (261), Expect = 6e-22
Identities = 71/239 (29%), Positives = 116/239 (48%), Gaps = 15/239 (6%)
Query: 868 EELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP---EEFEEVSIYFSDIVG 924
+E + + + + L+ +LP VA + R + + E + F+ I
Sbjct: 1020 KEQAEKELSNMKSNRHLNDLLIKNILPDHVASYYLSEERADELYAQMHELCGVMFASIPN 1079
Query: 925 FTALAARS--TAVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTR- 978
F + + +LN++ + FD+ +E+ R V K++T+G YM L +
Sbjct: 1080 FKDFYSEDIENGKACIRILNEIISDFDSLLEEERFKTVEKIKTVGATYMAASNLRSGNKT 1139
Query: 979 --DHAESVATMALHLLHLAGRFRVRHLPDTPLH---LRIGLHTGPCCAGVVGLTMPRYCL 1033
D + A L LA R +++ + + LR+G+ +GP +GV+G P Y +
Sbjct: 1140 KVDEKDEEAVCDLVEFALAMRQKLQEVNKDAFNTFQLRVGISSGPLVSGVIGARKPVYDI 1199
Query: 1034 FGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLG 1092
+G+TVN ASRM+STG W++Q+ TA LL GY RG +KGKG M TYW+LG
Sbjct: 1200 WGNTVNVASRMDSTGENWKVQVPDYTA-ALLQTKGYTCVQRGEVNVKGKGLMLTYWVLG 1257
Score = 89.8 bits (213), Expect = 4e-16
Identities = 61/205 (29%), Positives = 100/205 (48%), Gaps = 20/205 (9%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE--------------FEEVSIY 918
E + + E ++T++LL+ +LP V + PE+ + VSI
Sbjct: 312 EHKRESEKEYQRTQRLLDSILPMFVNNDIRKEMYKSPEQPQVDTQFKKLYIYHMDNVSIL 371
Query: 919 FSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT- 977
F+DI GFT LA++++A Q+V +LNDL+ FD E +++ +GD Y V ++
Sbjct: 372 FADIKGFTELASKTSAQQLVKVLNDLFARFDKIAEDNHCLRIKLLGDCYYCVSMFDSQSW 431
Query: 978 ---RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLF 1034
DHA LH++ RV+ + L +RIG+H+G GV+G + ++
Sbjct: 432 KSRPDHAVCSVETGLHMIKAIKDVRVQ--TNVDLDMRIGIHSGSVMCGVLGEKKWHFDVW 489
Query: 1035 GDTVNTASRMESTGAAWRIQISSTT 1059
+ V A+ MES G R+ IS T
Sbjct: 490 SNDVIIANHMESGGVPGRVHISEAT 514
>UniRef50_Q54H46 Cluster: Protein kinase, TKL group; n=1;
Dictyostelium discoideum AX4|Rep: Protein kinase, TKL
group - Dictyostelium discoideum AX4
Length = 642
Score = 108 bits (260), Expect = 8e-22
Identities = 70/208 (33%), Positives = 105/208 (50%), Gaps = 16/208 (7%)
Query: 627 LMQNLRQENVNPFIG-CLCEGRPALVFDECWRGSLEDVLMADDIKLDWTFRLSLLSDLVK 685
LM+NLR NV F+G CL + + RGSL +L ++L W+ + ++ D K
Sbjct: 422 LMKNLRHPNVIQFLGSCLIPPDICICTEYMPRGSLYSILHDQALQLQWSLLIKMMIDAAK 481
Query: 686 GMRYLHGS-PLRAHGRLSSRNCVVDSRWVLRVTDYGLPALHRTQGLPPAQRTPRELLWTA 744
G+ YLH S P+ H L S N +VD W ++V D+GL + + A TP WT+
Sbjct: 482 GVIYLHNSTPVILHRDLKSHNLLVDENWKVKVADFGLSTIEQQGATMTACGTP---CWTS 538
Query: 745 PELIREAREGGGWLATQSGDVFSFAIIMQEVIVRGEPYCMLSFTPEEIIDKLCRPPPLIR 804
PE++R R T+ DV+SF II+ E R +PY P ++I + R +R
Sbjct: 539 PEVLRSQR------YTEKADVYSFGIILWECATRQDPY--FGIPPFQVIFAVGREG--MR 588
Query: 805 PSVSMGAAPPEAVSVMRQCWSEAPDLRP 832
P V PP+ + ++ C +E P RP
Sbjct: 589 PPVPQN-GPPKYIQLLIDCLNENPSHRP 615
>UniRef50_UPI00006CB3C2 Cluster: Adenylate and Guanylate cyclase
catalytic domain containing protein; n=1; Tetrahymena
thermophila SB210|Rep: Adenylate and Guanylate cyclase
catalytic domain containing protein - Tetrahymena
thermophila SB210
Length = 2982
Score = 108 bits (259), Expect = 1e-21
Identities = 61/198 (30%), Positives = 112/198 (56%), Gaps = 8/198 (4%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEE----FEEVSIYFSDIVGFTALAARST 933
LD +K++ + L+ ++P+ + + + S + + FEE ++ F+DI FT +
Sbjct: 2681 LDAKKQQKDNLVRNLIPKHLLDYFNVKSIAQQTDLCDVFEEATLLFADITDFTKYCSMRN 2740
Query: 934 AVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD---HAESVATMALH 990
+VV++L++L+ FD ++ + +KV TIGD Y+V+G + R+ A +V M L+
Sbjct: 2741 PEEVVNMLSNLFLKFDMKCQELKCFKVYTIGDCYVVLGVDNAKERNPAKEANNVVQMGLN 2800
Query: 991 LLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAA 1050
+L + + R +T L++RIG+HTG G+ G + RY ++G V +++MES G
Sbjct: 2801 MLEIIKQVRSEVNFET-LNMRIGIHTGQIIGGITGSDIVRYDIYGTDVMLSNKMESNGEP 2859
Query: 1051 WRIQISSTTAEKLLAAGG 1068
+I +S TT + L +A G
Sbjct: 2860 GKIMVSQTTKDLLESAYG 2877
Score = 91.9 bits (218), Expect = 1e-16
Identities = 69/228 (30%), Positives = 103/228 (45%), Gaps = 16/228 (7%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEE----VSIYFSDIVGFTALAARS 932
+L+++ KK +L +LP+ + R+ +P F+E SI F DI F +
Sbjct: 1849 ELNIQNKKINDVLEILLPKFIINRIKSNDPNKPFRFQEKQGEASIIFCDICHFDDIIKEK 1908
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLP---------QRTRDHAES 983
+++ L+ ++ FD + + K+ET+G YM GL QR D E
Sbjct: 1909 NE-KIIPFLDKVFKNFDQFCARQGLQKIETVGKTYMASAGLKDFEDQVDIRQREIDPVER 1967
Query: 984 VATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASR 1043
A +AL +L + L L+IG+H G AGV+G P++ L GDTVNT SR
Sbjct: 1968 AANLALEMLDYVKDLKWSQNGKN-LELKIGIHYGQVIAGVIGHHKPQFSLIGDTVNTTSR 2026
Query: 1044 MESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQI-KGKGAMHTYWL 1090
+ S G + IS EK+ S T KGKG + Y L
Sbjct: 2027 VCSKGNPSEVTISEQAFEKIQGKTNQFFFSDPKTVFAKGKGDITLYTL 2074
>UniRef50_UPI000069E67B Cluster: Adenylate cyclase type 1 (EC 4.6.1.1)
(Adenylate cyclase type I) (ATP pyrophosphate-lyase 1)
(Adenylyl cyclase 1) (Ca(2+)/calmodulin- activated
adenylyl cyclase).; n=1; Xenopus tropicalis|Rep:
Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase
type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1)
(Ca(2+)/calmodulin- activated adenylyl cyclase). -
Xenopus tropicalis
Length = 781
Score = 108 bits (259), Expect = 1e-21
Identities = 73/242 (30%), Positives = 128/242 (52%), Gaps = 20/242 (8%)
Query: 871 IRERTEQLDMEKKKTE--QLLNRMLPRSVAERLMLGSR----VEPEEFEEVSIYFSDIVG 924
++ E+ DME+ K + ++L +LP VA+ ++ + + + + +V + F+ I
Sbjct: 537 VQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 596
Query: 925 FT----ALAARSTAVQVVDLLNDLYTTFDAAIEQ--YR-VYKVETIGDAYMVVGGLPQRT 977
F L + V+ + LLN++ FD +E+ Y+ + K++TIG YM GL T
Sbjct: 597 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGLVPTT 656
Query: 978 RDHAES-----VATMALHLLHLAGRF-RVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRY 1031
A+ ++T+A + + + + LR+G++ GP AGV+G P+Y
Sbjct: 657 GTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNEFVLRVGINVGPVVAGVIGARRPQY 716
Query: 1032 CLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLL 1091
++G+TVN ASRM+STG +IQ++ ++L + Y+ RG +KGKG M TY+L
Sbjct: 717 DIWGNTVNVASRMDSTGVQGKIQVTE-DVHRILKSCNYEFVCRGKVSVKGKGEMLTYFLE 775
Query: 1092 GK 1093
GK
Sbjct: 776 GK 777
Score = 100 bits (239), Expect = 3e-19
Identities = 54/148 (36%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Query: 916 SIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ 975
SI F+DIVGFT+LA++ TA ++V LLN+L+ FD + +++ +GD Y V GL Q
Sbjct: 1 SILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQ 60
Query: 976 RTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
DHA M L ++ V + L++R+GLHTG GV+GL +Y ++
Sbjct: 61 PKTDHAHCCVEMGLDMIDTI--TSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS 118
Query: 1036 DTVNTASRMESTGAAWRIQISSTTAEKL 1063
+ V A+ ME+ G ++ I+ T E L
Sbjct: 119 NDVTLANVMEAGGLPGKVHITKNTLECL 146
>UniRef50_Q5TUN5 Cluster: ENSANGP00000027378; n=2; Culicidae|Rep:
ENSANGP00000027378 - Anopheles gambiae str. PEST
Length = 2040
Score = 108 bits (259), Expect = 1e-21
Identities = 73/232 (31%), Positives = 121/232 (52%), Gaps = 15/232 (6%)
Query: 852 IVDSMFEMLEKYSN-NLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLM--LGSRVE 908
+V+ M E ++ + + I R E D E +K E+LL +LP+ VA + + S VE
Sbjct: 202 VVNVMMERAQRRAFLDTRNCIAARLEMED-ENEKLERLLLSVLPQHVAMEMKNDILSPVE 260
Query: 909 PE-------EFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVE 961
+ + E VSI F+DIVGFT LA++ +A ++V LLN+L+ FD +++
Sbjct: 261 GQFHKIYIQKHENVSILFADIVGFTVLASQCSAQELVRLLNELFGRFDQLAHDNHCLRIK 320
Query: 962 TIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCA 1021
+GD Y V G+P DHA M L ++ V D L++R+G+H+G
Sbjct: 321 ILGDCYYCVSGIPDPRADHARCAVEMGLDMIDAIA--SVVEQTDVILNMRVGIHSGRVLC 378
Query: 1022 GVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRS 1073
GV+GL ++ ++ + V A+ MES G R+ ++ T + L G Y++ +
Sbjct: 379 GVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDAL--GGEYEVEA 428
Score = 94.3 bits (224), Expect = 2e-17
Identities = 66/239 (27%), Positives = 124/239 (51%), Gaps = 22/239 (9%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLM----LGSRVE--PEEFEEVSIYFSDIVGF- 925
+ +++ + ++ ++L +LP VA + S ++ + + +V + F+ + F
Sbjct: 907 QEKKEMSVLQQSNRRILYNLLPSHVAAHFLDNQFARSNMDLYHQSYSKVGVIFASVPNFH 966
Query: 926 ---TALAARSTAVQVVDLLNDLYTTFDAAIEQYRVY---KVETIGDAYMV-VGGLPQRTR 978
T L + V+ + LLN++ FD + + R + K++T+G YM VG +P+
Sbjct: 967 EFYTELDGSNQGVECLRLLNEIIADFDELLCEERFHAIDKIKTVGSTYMAAVGLIPEHKM 1026
Query: 979 DHAE--SVATMALHLLHLAGRFRV--RHLPDTPLH---LRIGLHTGPCCAGVVGLTMPRY 1031
+E S+ + L+ RV +++ + + LR+G++ GP AGV+G P+Y
Sbjct: 1027 LPSEPGSMRRLMTALVDFVKAMRVTLKNINENSYNNFMLRVGVNVGPVVAGVIGARKPQY 1086
Query: 1032 CLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
++G+TVN ASRM+STG Q++ + L ++ R RG ++KGKG M TY+L
Sbjct: 1087 DIWGNTVNVASRMDSTGIPGYTQVTQEVVDS-LQGSHFEFRCRGQIKVKGKGDMVTYFL 1144
>UniRef50_A2F2E6 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=3; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1597
Score = 108 bits (259), Expect = 1e-21
Identities = 69/226 (30%), Positives = 122/226 (53%), Gaps = 8/226 (3%)
Query: 868 EELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTA 927
+ ++ E+ +Q D K +E+LL ++LPR + ++ G + SI F DIV F+
Sbjct: 1327 QTVLMEQQKQADAAKATSEKLLYQILPRDIVVQINRGEKNISFTVSSASIVFIDIVKFSD 1386
Query: 928 LAARSTAVQVVDLLNDLYTTFDAAIEQYRVY-KVETIGDAYMVVGGL--PQRT-RDHAES 983
++ T +++ L+ + T D + ++ + K++ IGD YM GGL P+ + HAE
Sbjct: 1387 YSSSLTPQEIMANLSHYFNTLDTIMAKFDLLTKIKLIGDIYMAAGGLFNPELPPQKHAEQ 1446
Query: 984 VATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTG-PCCAGVVGLTMPRYCLFGDTVNTAS 1042
+ + ++ +R + L +R+G++TG P AGV+G P + + GD +N AS
Sbjct: 1447 MVLFSTEVIGELEEINLRL--NCSLSVRVGVNTGGPIIAGVLGKDKPVFDIIGDPINIAS 1504
Query: 1043 RMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
R++ST A +QIS +T E ++ ++ RG +KGKG+ TY
Sbjct: 1505 RLQSTDIANHVQISQSTYE-MINHLNLNVKPRGEVFLKGKGSQMTY 1549
>UniRef50_A2EN10 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1096
Score = 108 bits (259), Expect = 1e-21
Identities = 68/211 (32%), Positives = 111/211 (52%), Gaps = 6/211 (2%)
Query: 881 EKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDL 940
EK K E+L+ +LP S+ +R+ G E ++ ++ F+ IVG++ L A QV+ +
Sbjct: 874 EKAKGEKLIESLLPPSIIKRMNEGETDITFEVQQATVLFTSIVGWSNLTQDMKATQVMTI 933
Query: 941 LNDLYTTFDAAIEQY-RVYKVETIGDAYMVVGGL-PQRTRDHAESVATMALHLLHLAGRF 998
LN L+ +D + + + K++TIG YM GGL + + + V A LL +A
Sbjct: 934 LNSLFVAYDEELHNFPAITKMKTIGHIYMCCGGLFSDSSVNSGQVVVEYATKLLEIAQ-- 991
Query: 999 RVRHLPDTPLHLRIGLHT-GPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISS 1057
+V + G++T GP G++G+T P + + GD VN ASRM +QIS
Sbjct: 992 KVSKDLGISFQITCGVNTGGPIKCGILGVTRPVFDIIGDVVNVASRMNLHCLPGYVQISP 1051
Query: 1058 TTAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
+T + + + ++ RG Q+KGKG M TY
Sbjct: 1052 STYDAIKYL-NFNVKERGEIQVKGKGMMKTY 1081
>UniRef50_A2E7P5 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Trichomonas vaginalis
G3|Rep: Adenylate and Guanylate cyclase catalytic domain
containing protein - Trichomonas vaginalis G3
Length = 1457
Score = 108 bits (259), Expect = 1e-21
Identities = 69/223 (30%), Positives = 112/223 (50%), Gaps = 8/223 (3%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARS 932
E+ + + K K+E+LL ++LPR + +L G + +I F DI F+ AA
Sbjct: 1221 EQKKAAEEAKAKSEKLLYQILPRDIVVQLNRGEKDISFVVPSATIIFIDINKFSEYAANL 1280
Query: 933 TAVQVVDLLNDLYTTFDA-AIEQYRVYKVETIGDAYMVVGGL---PQRTRDHAESVATMA 988
+ ++ L+ + D A + + K++ IGD YM GL HAE V A
Sbjct: 1281 SPQDIMANLSYYFACIDKLAAKHTMITKIKLIGDIYMAAAGLFNLDSPPESHAEQVIQFA 1340
Query: 989 LHLLHLAGRFRVRHLPDTPLHLRIGLHTG-PCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
+ + + ++ D L +RIG++TG P AGV+G P + + GD +N A+R++ST
Sbjct: 1341 IECVSILDEVNIKL--DASLQIRIGINTGGPVIAGVLGTDKPAFDIIGDPINVAARLQST 1398
Query: 1048 GAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
I IS T + L+ Y++ RG T +KGKG TY++
Sbjct: 1399 DEVNHIHISQATFD-LIRGSNYEVTQRGETFLKGKGKQMTYYV 1440
>UniRef50_Q5MAL0 Cluster: Adenylate cyclase; n=2; Eukaryota|Rep:
Adenylate cyclase - Aplysia californica (California sea
hare)
Length = 1339
Score = 107 bits (258), Expect = 1e-21
Identities = 61/192 (31%), Positives = 106/192 (55%), Gaps = 11/192 (5%)
Query: 881 EKKKTEQLLNRMLPRSVAERLM---------LGSRVEPEEFEEVSIYFSDIVGFTALAAR 931
+ +K E++L +LP+ VA + + ++ + + V+I F+DIVGFT L+++
Sbjct: 255 QNEKLERILMSVLPQHVAMEMKNDITTPHHGMFHKIYIQLHDNVTILFADIVGFTCLSSQ 314
Query: 932 STAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHL 991
TA ++V +LN+L+ FD +Q +++ +GD Y V GLP+ +HA M L +
Sbjct: 315 CTAQELVRILNELFGRFDQLAKQNNCMRIKILGDCYYCVSGLPEARANHAACCVEMGLDM 374
Query: 992 LHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAW 1051
+ V L++R+GLHTG GV+GL +Y +F + V A+ ME+ G A
Sbjct: 375 IDAIA--SVCDQTGVKLNMRVGLHTGRVLCGVLGLKKWQYDVFSNDVKLANHMEAGGIAG 432
Query: 1052 RIQISSTTAEKL 1063
R+ I+ +T ++L
Sbjct: 433 RVHITKSTLDQL 444
Score = 105 bits (253), Expect = 6e-21
Identities = 71/228 (31%), Positives = 124/228 (54%), Gaps = 21/228 (9%)
Query: 882 KKKTEQLLNRMLPRSVAER---LMLGSRVE--PEEFEEVSIYFSDIVGFT----ALAARS 932
+++ ++L +LP VA L S +E +++ +V+++F+ I F+ LAA +
Sbjct: 865 QRQNSRILCNLLPEHVANHFLHLQTNSHMELYSQQYNKVAVFFASIPNFSDFYVELAANN 924
Query: 933 TAVQVVDLLNDLYTTFDAAIEQ---YRVYKVETIGDAYMVVGGL-PQRTRDHAESVATMA 988
V+ + +LN++ FD ++ Y V K++TIG YM GL P E T
Sbjct: 925 QGVECLRVLNEIIADFDELLDIPYFYGVEKIKTIGSCYMAATGLKPTHLVKGREDSITFY 984
Query: 989 LHLLH---LAGRFRVRHLPDTPLH---LRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTAS 1042
L +L ++ + +++++ + + LR+G++ GP AGV+G P+Y ++G+TVN AS
Sbjct: 985 LTMLVDFVMSMKEKLKNINENSYNNFELRVGINVGPVVAGVIGARKPQYDIWGNTVNVAS 1044
Query: 1043 RMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
RMESTG + +IQ++ L + + RG +KGKG M TY+L
Sbjct: 1045 RMESTGVSSKIQVTEEVYAVLKSV--FTFECRGKVPVKGKGDMITYFL 1090
>UniRef50_A7SS39 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 592
Score = 107 bits (258), Expect = 1e-21
Identities = 54/131 (41%), Positives = 82/131 (62%), Gaps = 2/131 (1%)
Query: 599 YKGDAVHLRHLQVTGTLELKRKSTDVLLLMQNLRQENVNPFIG-CLCEGRPALVFDECWR 657
YKG+ V ++ L +++L R L M++LR +N+ F+G C+ +V C +
Sbjct: 451 YKGNLVAVKRL-AKKSVDLTRTVLMELKQMRDLRHDNLAQFMGACVESPNICIVVQYCPK 509
Query: 658 GSLEDVLMADDIKLDWTFRLSLLSDLVKGMRYLHGSPLRAHGRLSSRNCVVDSRWVLRVT 717
GS++D+L D+KLD F SL+SD+V+GM +L + L++HG L S NC+VDSRWVL++T
Sbjct: 510 GSVQDILQNKDVKLDHMFIASLVSDIVRGMAFLQSTDLKSHGNLKSSNCLVDSRWVLKIT 569
Query: 718 DYGLPALHRTQ 728
DYGL Q
Sbjct: 570 DYGLSTFRAKQ 580
>UniRef50_Q8NFM4 Cluster: Adenylate cyclase type 4; n=73;
Euteleostomi|Rep: Adenylate cyclase type 4 - Homo sapiens
(Human)
Length = 1077
Score = 107 bits (258), Expect = 1e-21
Identities = 76/240 (31%), Positives = 123/240 (51%), Gaps = 21/240 (8%)
Query: 871 IRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR----VEPEEFEEVSIYFSDIVGFT 926
+R+ E+ + + T LL +LP VA + + +R + + +E V + F+ + F
Sbjct: 824 LRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFK 883
Query: 927 ALAARST----AVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTRD 979
+ S ++ + LLN++ FD + + + V K++TIG YM GL +
Sbjct: 884 EFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQ 943
Query: 980 HAESVA--------TMALHLLHLAGRFRVRHLPD-TPLHLRIGLHTGPCCAGVVGLTMPR 1030
A+ A TM + L + V + LR+GL+ GP AGV+G P+
Sbjct: 944 DAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQ 1003
Query: 1031 YCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWL 1090
Y ++G+TVN ASRMESTG +IQ++ TA L + GY SRG+ ++KGKG + TY+L
Sbjct: 1004 YDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL-GYTCYSRGVIKVKGKGQLCTYFL 1062
Score = 103 bits (247), Expect = 3e-20
Identities = 68/219 (31%), Positives = 108/219 (49%), Gaps = 23/219 (10%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAE--------RLMLGSRVEPEE-----------FEEVSI 917
+LD EKK E LL +LP +A RL G PE + VS+
Sbjct: 215 RLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSV 274
Query: 918 YFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRT 977
++DIVGFT LA+ + ++V +LN+L+ FD +++ +++ +GD Y V GLP
Sbjct: 275 LYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSL 334
Query: 978 RDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDT 1037
DHA + M L + + R D +++R+G+H+G GV+GL +Y ++
Sbjct: 335 PDHAINCVRMGLDMCRAIRKLRAATGVD--INMRVGVHSGSVLCGVIGLQKWQYDVWSHD 392
Query: 1038 VNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGL 1076
V A+ ME+ G R+ I+ T L AG Y + G+
Sbjct: 393 VTLANHMEAGGVPGRVHITGATL--ALLAGAYAVEDAGM 429
>UniRef50_Q4RR06 Cluster: Chromosome 14 SCAF15003, whole genome
shotgun sequence; n=7; Clupeocephala|Rep: Chromosome 14
SCAF15003, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1077
Score = 107 bits (257), Expect = 2e-21
Identities = 77/238 (32%), Positives = 122/238 (51%), Gaps = 20/238 (8%)
Query: 872 RERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPE----EFEEVSIYFSDIVGFTA 927
++ E + ++ E LL +LP VA + S+ + E ++EV + F+ I GF
Sbjct: 799 QQEVEDMRELREHNECLLYNILPVHVARHFLDRSKNDEELYSQSYDEVGVMFASIAGFNE 858
Query: 928 L----AARSTAVQVVDLLNDLYTTFDAAIEQ-YRVY--KVETIGDAYMVVGGL-PQR--T 977
+ V + LLN++ FD +E+ Y Y K++TIG YM GL P R +
Sbjct: 859 YFEQKEIKHEGVDCLRLLNEIIAGFDELLEESYFSYVEKIKTIGSCYMAASGLAPDRQVS 918
Query: 978 RDHAESVATMALHLLHLAGRFRVRHLPDTP-LHLRIGLHTGPCCAGVVGLTMPRYCLFGD 1036
D ++ + L L + + + T LR+G+ GP AGV+G T P+Y ++G
Sbjct: 919 MDEWNHLSELVLFALAMQETLKEINRHSTKNFQLRVGIAHGPVVAGVIGATKPQYDIWGS 978
Query: 1037 TVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKG----KGAMHTYWL 1090
TVN ASRM+STG + RIQ+ T +K+L G+ L RG +KG +G + TY++
Sbjct: 979 TVNLASRMDSTGVSGRIQVPEAT-KKILTEWGFVLELRGEIFVKGVSERQGKVRTYFI 1035
Score = 88.2 bits (209), Expect = 1e-15
Identities = 53/155 (34%), Positives = 84/155 (54%), Gaps = 4/155 (2%)
Query: 916 SIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ 975
SI F+DI GFT L+ +A +V LN+L+ FD E++ +++ +GD Y V G+P+
Sbjct: 302 SILFADIKGFTLLSMNLSAQDLVRTLNELFGRFDRLAEEHHCLRIKILGDCYYCVSGVPE 361
Query: 976 RTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFG 1035
R HA M L +++ R+ VR + +RIG+H+G GV+GL ++ ++
Sbjct: 362 PQRAHARHCVEMGLAMINTI-RY-VRKQLKFEVDMRIGIHSGSVLCGVLGLQKWQFDVWS 419
Query: 1036 DTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYK 1070
V A+ +E+ G RI IS T + L G YK
Sbjct: 420 WDVGIANMLEAGGIPGRIHISRATLDCL--EGTYK 452
>UniRef50_Q23DS0 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=1; Tetrahymena thermophila
SB210|Rep: Adenylate and Guanylate cyclase catalytic
domain containing protein - Tetrahymena thermophila SB210
Length = 3179
Score = 107 bits (256), Expect = 2e-21
Identities = 62/188 (32%), Positives = 102/188 (54%), Gaps = 10/188 (5%)
Query: 879 DMEKKKTEQLLNRMLPRSVAERLMLG---SRVEPEEFEEVSIYFSDIVGFTALAARSTAV 935
D +K + +LL +LP + +R + + + E+F + ++ F+DI GFTA ++
Sbjct: 2948 DHQKHQEVRLLVHLLPSHIFDRFLRNPEDNSIFTEKFTQTTLLFADISGFTAYSSNKKPE 3007
Query: 936 QVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD---HAESVATMALHLL 992
QVV +L L+T FD ++ V+K+ TIGD Y+V+G RD A++V M ++
Sbjct: 3008 QVVHMLKSLFTKFDHKCIKHNVFKLYTIGDCYIVMGFSDANKRDPPAEAKNVLEMGFSMI 3067
Query: 993 HLAGRFRVRHL----PDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
+FR+ + +H+RIG+H G GV+G + RY ++G V A++MES G
Sbjct: 3068 ESLRQFRLEQKDPSDQNADIHMRIGIHIGDIIGGVIGKNVVRYDIYGKDVLLANKMESNG 3127
Query: 1049 AAWRIQIS 1056
RI IS
Sbjct: 3128 ERGRILIS 3135
Score = 102 bits (245), Expect = 5e-20
Identities = 63/195 (32%), Positives = 97/195 (49%), Gaps = 10/195 (5%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQ 936
Q EK + + +L +LP + E ++LG + EE SI F D+ F + R +
Sbjct: 2192 QFQEEKSQRQDILGILLPEFIREDVILGKTNFSRDQEEASILFCDVSDFDKIMDRED-YK 2250
Query: 937 VVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAESVATMALHLLHLAG 996
+V LL++L+ FD QY + K+ET+G YM GGL ++ ++ + T + H + +
Sbjct: 2251 IVSLLDNLFREFDELTFQYGLQKIETVGKTYMAAGGLKAVEKNLSKKI-TKSHHFIRMLI 2309
Query: 997 RFRVRHLPDT--------PLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
H P+ L+IG+H GP AGV+G P++ L GDTVNT SR+ S
Sbjct: 2310 MSNKMHQVAAKSQWGDGYPVKLKIGVHIGPITAGVIGYHKPQFSLIGDTVNTTSRLCSNC 2369
Query: 1049 AAWRIQISSTTAEKL 1063
R S EK+
Sbjct: 2370 EPGRSLFSDIIFEKI 2384
>UniRef50_UPI0000DB73AC Cluster: PREDICTED: similar to Adenylyl
cyclase 76E CG7978-PA; n=1; Apis mellifera|Rep:
PREDICTED: similar to Adenylyl cyclase 76E CG7978-PA -
Apis mellifera
Length = 969
Score = 106 bits (255), Expect = 3e-21
Identities = 78/270 (28%), Positives = 134/270 (49%), Gaps = 27/270 (10%)
Query: 850 INIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSR--- 906
++++D E + E ++ ++++ + + LL +LP VAE + R
Sbjct: 699 LHVLDRQIEYTSRTDFLWESKLKIEQDEVETMRGINKILLENILPAHVAEHFLTNVRAIQ 758
Query: 907 -VEPEEFEEVSIYFSDIVGFTALAARST----AVQVVDLLNDLYTTFDAAIEQYR---VY 958
+ E + +++ F+ I + + ++ + LLN++ FD + + + +
Sbjct: 759 DLYHERYSSIAVMFASIPNYKEFYDETDINKQGLECLRLLNEIICDFDKLLLKPKFSGIE 818
Query: 959 KVETIGDAYMVVGGL-PQRTRDHAE----------SVATMALHLLHLAGRFRVRHLPDTP 1007
K++TIG YM+ GL P + D E + AL L+ + +
Sbjct: 819 KIKTIGSTYMLASGLSPGKDTDEKELLKQENHNIIILIEFALALMTILDQINKESF--QK 876
Query: 1008 LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAG 1067
LRIGL+ GP AGVVG P+Y ++G+TVN ASRM+S G ++Q++ TA K+L A
Sbjct: 877 FKLRIGLNHGPVIAGVVGAQKPQYDIWGNTVNVASRMDSCGEMGKVQVTEDTA-KILIAA 935
Query: 1068 GYKLRSRGLTQIKGKGAMHTYWLLGKEGFD 1097
GY+L RG T +KGKG + TY++ K FD
Sbjct: 936 GYELICRGPTYVKGKGTLITYFV--KTPFD 963
Score = 95.9 bits (228), Expect = 6e-18
Identities = 53/154 (34%), Positives = 86/154 (55%), Gaps = 2/154 (1%)
Query: 910 EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMV 969
+ VSI ++DIV FT L+ + +A +V +LN+L+ FD + + +++ +GD Y
Sbjct: 265 QRHNNVSILYADIVNFTPLSEQLSASSLVKILNELFGRFDQIAQDNQCMRIKILGDCYYC 324
Query: 970 VGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMP 1029
V GLP +HA + TM L ++ A +F VR + +RIG+HTG GV+GL
Sbjct: 325 VSGLPISRPNHAYNCVTMGLQMID-AIKF-VREATGFNVDMRIGIHTGNVLCGVLGLRKW 382
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKL 1063
++ ++ D V A+ MES G R+ I+ T +L
Sbjct: 383 QFDVWSDDVTLANHMESGGLPGRVHITKATLLQL 416
>UniRef50_Q231I7 Cluster: Adenylate and Guanylate cyclase catalytic
domain containing protein; n=2; Tetrahymena|Rep:
Adenylate and Guanylate cyclase catalytic domain
containing protein - Tetrahymena thermophila SB210
Length = 2997
Score = 106 bits (255), Expect = 3e-21
Identities = 67/215 (31%), Positives = 116/215 (53%), Gaps = 11/215 (5%)
Query: 852 IVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP-- 909
I+ +F ++ N+ + +QLD + + +LL +LP + + + L ++ +
Sbjct: 2728 ILTQLFNSFQQLELNITSF--QNRKQLDAKVSEQNKLLQYLLPSHIRD-MFLQNQAKTIN 2784
Query: 910 --EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAY 967
+ F+ V+I ++DI GFT +A VV +L +L+T FD ++ V+K+ TIGD Y
Sbjct: 2785 LIDNFDNVTILYADIAGFTKYSASVRPENVVFMLRELFTKFDQKCQENDVFKLYTIGDCY 2844
Query: 968 MVVGGLPQRTRDHAE---SVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVV 1024
+V+G + RD+A+ +V M ++ + + R D L +RIG+HTG GVV
Sbjct: 2845 VVMGLVNIENRDYAKEALNVIKMGFCMIDIIQQVRAVVNFD-ELEMRIGIHTGSIIGGVV 2903
Query: 1025 GLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTT 1059
G + RY ++G V A++MES G + R+ IS T
Sbjct: 2904 GTGVVRYDIYGPDVVIANKMESNGESGRVMISEAT 2938
Score = 95.9 bits (228), Expect = 6e-18
Identities = 64/196 (32%), Positives = 99/196 (50%), Gaps = 13/196 (6%)
Query: 873 ERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARS 932
E+ +L E KK +L+ +LP+ + E + E+ EV+I F DI F ++ +
Sbjct: 2158 EKINKLQNESKKMNDVLSILLPKFIRENIQEKGLSYQEDQGEVAILFCDICDFDSVIEQE 2217
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLP----------QRTRDH-A 981
V+ LL+ L+ +D + Y + K+ET+G YM GGL R H
Sbjct: 2218 KK-NVIKLLDKLFRIYDESCSNYGLQKIETVGKTYMAAGGLKGIPPVKKYLINNERIHPV 2276
Query: 982 ESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTA 1041
+ MA + A + + D L+++IG+H G AGV+G P++ L GDTVN A
Sbjct: 2277 TNSVLMAYDMYENAKKITYGNKSDK-LNVKIGIHYGRVMAGVIGGHKPQFSLIGDTVNMA 2335
Query: 1042 SRMESTGAAWRIQISS 1057
SR+ STGAA + IS+
Sbjct: 2336 SRVCSTGAADSVTISA 2351
>UniRef50_A0CQM4 Cluster: Chromosome undetermined scaffold_24, whole
genome shotgun sequence; n=5; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_24, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2488
Score = 106 bits (255), Expect = 3e-21
Identities = 62/192 (32%), Positives = 102/192 (53%), Gaps = 8/192 (4%)
Query: 877 QLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEV----SIYFSDIVGFTALAARS 932
Q + + K Q+L +LP+ + R + F +V +I F+DI GFT ++
Sbjct: 2255 QFESKNAKQTQILQYLLPQHIIGRFFSTDITTTDNFTDVFENCTILFADIAGFTKYSSSV 2314
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD---HAESVATMAL 989
QVV++L L+ FD A ++++VYK+ TIGD Y+ +G + RD A +V L
Sbjct: 2315 EPEQVVNMLRILFQQFDEACQKFQVYKLYTIGDCYVCMGIIDANNRDPVGEAINVVLFGL 2374
Query: 990 HLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
++ + + + L++RIG HTG GVVG + RY ++G+ V TA++MES G
Sbjct: 2375 KMIQIIQQIN-KDPQFQHLNMRIGAHTGRVIGGVVGTDVVRYDIYGEDVTTANKMESKGQ 2433
Query: 1050 AWRIQISSTTAE 1061
+I +S T +
Sbjct: 2434 EGKIMVSQATKD 2445
Score = 106 bits (254), Expect = 4e-21
Identities = 69/210 (32%), Positives = 106/210 (50%), Gaps = 5/210 (2%)
Query: 881 EKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQVVDL 940
E KK L ++PR + ER+ G E+ +V+I F DI F + R+ ++VV+
Sbjct: 1538 EYKKLNDALGLLMPRFIKERMSKGQIQISEDQGDVAILFCDIYDFDDII-RNEQIKVVEF 1596
Query: 941 LNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQ-RTRDHAESVATMALHLLHLAGRFR 999
L++LY FD + + K+ET+G YM GGL D+ + L + +
Sbjct: 1597 LDNLYRQFDQFCQANELQKIETVGKTYMAAGGLKDYNMSDNLNPTERILDAALQMQESVK 1656
Query: 1000 VRHLPDTP-LHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISST 1058
D + L+IG+H G AGV+G P++ L GDTVNT SR+ ST I +S
Sbjct: 1657 TMKYGDKKAVILKIGIHYGRVIAGVIGAHKPQFSLIGDTVNTTSRVCSTSEPGIITLSQQ 1716
Query: 1059 TAEKLLAAGGYKLRSRGLTQIKGKGAMHTY 1088
EK ++ Y+ + R + + KGKG + TY
Sbjct: 1717 AYEK-VSNKKYQFKLREV-EAKGKGTIKTY 1744
>UniRef50_Q6BG52 Cluster: Guanylyl cyclase, putative; n=4; Paramecium
tetraurelia|Rep: Guanylyl cyclase, putative - Paramecium
tetraurelia
Length = 2634
Score = 106 bits (254), Expect = 4e-21
Identities = 70/244 (28%), Positives = 120/244 (49%), Gaps = 8/244 (3%)
Query: 850 INIVDSMFEMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEP 909
+ I +FE ++K+ L+ +L++E+KK +L ++PR + ER+ G
Sbjct: 1587 VEISYPIFENVQKFQF-LQRSSYIYQNRLNIEQKKINYILGLLMPRFIQERMNKGQIQIQ 1645
Query: 910 EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMV 969
++ +V+I F DI F + + +++ L+ LY FD + Y + K+ET+G YM
Sbjct: 1646 QDQGDVTILFCDIYQFDKVI-KYEQENILNFLDTLYRAFDQLCQTYDLQKIETVGKTYMA 1704
Query: 970 VGGLPQR----TRDHAESVATMALHLLHLAGRFRVRHLPDTP-LHLRIGLHTGPCCAGVV 1024
GGL + +A S + + + D + L+IG+H G AGV+
Sbjct: 1705 AGGLKDYDAVINQKNANSTTRALETAIAMMDAVKTMKYGDNQDVKLKIGIHYGRVIAGVI 1764
Query: 1025 GLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGA 1084
G+ P++ L GDTVNT SR+ STG A I +S + + Y+ + + KGKG
Sbjct: 1765 GVHKPQFSLIGDTVNTTSRVCSTGDAGFITLSESAYNNIKDTTKYQFDEKAVA-AKGKGT 1823
Query: 1085 MHTY 1088
+ T+
Sbjct: 1824 LLTF 1827
Score = 99 bits (238), Expect = 4e-19
Identities = 61/192 (31%), Positives = 103/192 (53%), Gaps = 8/192 (4%)
Query: 875 TEQLDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEV----SIYFSDIVGFTALAA 930
++QL + K E +L ++P +RL+ + E F +V ++ F+DI GFT ++
Sbjct: 2400 SQQLQTQIFKYENILQYLMPPHALKRLLQPESDKTETFIDVLDHATVLFADIAGFTKYSS 2459
Query: 931 RSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRDHAE---SVATM 987
VV++L +L+ +FD + ++YK+ TIGD Y+ +G L RD AE V
Sbjct: 2460 SVQPETVVEMLRNLFQSFDLYCQMAQIYKLFTIGDCYVCMGVLDYTKRDPAEEAQKVLAF 2519
Query: 988 ALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMEST 1047
L ++ + + + L++RIG+HTG GVVG + RY ++G+ V A+ MES+
Sbjct: 2520 GLKMIQIINDIK-QDPQYQHLNMRIGVHTGRVLGGVVGTDVVRYDIYGEDVTIANLMESS 2578
Query: 1048 GAAWRIQISSTT 1059
G ++ IS T
Sbjct: 2579 GTEGKMLISDYT 2590
>UniRef50_O16880 Cluster: Adenylyl cyclase protein 2; n=2;
Caenorhabditis|Rep: Adenylyl cyclase protein 2 -
Caenorhabditis elegans
Length = 1080
Score = 106 bits (254), Expect = 4e-21
Identities = 53/152 (34%), Positives = 89/152 (58%), Gaps = 2/152 (1%)
Query: 913 EEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGG 972
+ VSI F+DIV FT LAA+ TA +V LN+LY+ FD ++ + +++ +GD Y V G
Sbjct: 311 DNVSILFADIVNFTVLAAQLTAKDLVRTLNELYSKFDRDAQRLQCMRIKFLGDCYYCVSG 370
Query: 973 LPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYC 1032
+P +HA+ M L +++ + R+ D +++RIG+HTG G++GL ++
Sbjct: 371 MPVNRPNHADMCVVMGLEMINTIKQVRIATGVD--VNMRIGVHTGSVLCGIMGLRKWQFD 428
Query: 1033 LFGDTVNTASRMESTGAAWRIQISSTTAEKLL 1064
++ D V A+ MES G + I+ +T + LL
Sbjct: 429 IWSDDVTLANHMESAGVPGAVHITKSTKDMLL 460
Score = 70.5 bits (165), Expect = 3e-10
Identities = 35/80 (43%), Positives = 54/80 (67%), Gaps = 2/80 (2%)
Query: 1010 LRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAAWRIQISSTTAEKLLAAGGY 1069
LRIG+ GP AGV+G P+Y ++G+TVN ASRM++ G +I ++T ++L GGY
Sbjct: 973 LRIGMSVGPLVAGVIGAQKPQYDIWGNTVNLASRMDTHGEPRKIH-ATTDMGRVLQTGGY 1031
Query: 1070 KLRSRGLTQIKG-KGAMHTY 1088
+++SRG ++KG K M T+
Sbjct: 1032 RVQSRGKIRVKGVKEPMETF 1051
Score = 39.9 bits (89), Expect = 0.43
Identities = 30/119 (25%), Positives = 57/119 (47%), Gaps = 12/119 (10%)
Query: 874 RTEQLDMEKKK--TEQLLNRMLPRSVAERLMLGSRVEPE----EFEEVSIYFSDIVGFTA 927
+ E+ D+E + + L+ +LP SVA + + R E + E V + F+ I F
Sbjct: 801 QNEERDVETMQDINKILIENILPSSVAAKFLSPDRAVNELYARQHENVCVMFASIPNFKD 860
Query: 928 LAAR---STAVQVVDLLNDLYTTFDAAIEQYR---VYKVETIGDAYMVVGGLPQRTRDH 980
+ + ++ + LLN++ FD + + + V K++T+G YM GL + D+
Sbjct: 861 FWSEWDTNRKLECLRLLNEIVCEFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESEADY 919
>UniRef50_A0D3H6 Cluster: Chromosome undetermined scaffold_36, whole
genome shotgun sequence; n=2; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_36, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 2471
Score = 106 bits (254), Expect = 4e-21
Identities = 63/195 (32%), Positives = 109/195 (55%), Gaps = 8/195 (4%)
Query: 876 EQLDMEKKKTEQLLNRMLPRSVAERLM---LGSRVEPEEFEEVSIYFSDIVGFTALAARS 932
+Q++++K+ LL+ +LP V + + SR + + + +I F+DI GFT ++
Sbjct: 2245 QQIEIKKEDKMNLLSCLLPIHVLSQFLDDSTNSRKFSDVYNDCTILFADIAGFTKYSSSV 2304
Query: 933 TAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPQRTRD---HAESVATMAL 989
+VV +L +L+ FD + + V+K+ TIGD Y+V+G RD A +V M+L
Sbjct: 2305 QPEEVVSMLKNLFDEFDKLTQIHNVFKLYTIGDCYVVIGVTDNFKRDPIQEAFNVVEMSL 2364
Query: 990 HLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGA 1049
++L R + LH+RIG+HTG G++G + RY ++G + A++MES+
Sbjct: 2365 NMLEAISLVR-NQINYHDLHMRIGIHTGNVIGGIIGTDIIRYDVYGKDILIANKMESSSE 2423
Query: 1050 AWRIQISSTTAEKLL 1064
R+ IS TT +KL+
Sbjct: 2424 EGRVLISETT-KKLI 2437
Score = 84.2 bits (199), Expect = 2e-14
Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 12/229 (5%)
Query: 878 LDMEKKKTEQLLNRMLPRSVAERLMLGSRVEPEEFEEVSIYFSDIVGFTALAARSTAVQV 937
L++E+ K + +++ +LP V RL G E V I F D+ F + + +
Sbjct: 1550 LEIERSKHQSVMSLLLPPFVLGRLDQGHLDFSENQGLVGIIFVDMCSFDVIVSEEDQ-NI 1608
Query: 938 VDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLP---------QRTRDHAESVATMA 988
V L++++Y FD K+ET+G YM GL Q ++ E + +A
Sbjct: 1609 VQLMDNIYRQFDQICSSTNCQKIETVGKTYMACSGLKCVEKFQPKGQHLKNPIERLVELA 1668
Query: 989 LHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTG 1048
+ F+ L+IG+H G GV+G P++ L GDTVNT SR+ +
Sbjct: 1669 FGIQQEITNFKWG-TNQKSFGLKIGIHYGRVLMGVIGSIKPQFSLIGDTVNTTSRLCAHC 1727
Query: 1049 AAWRIQISSTTAEKLLAAGGYKLRSRGLTQIKGKGAMHTYWLLGKEGFD 1097
IQ+S +++ K + + + KGKG + T+ + K F+
Sbjct: 1728 PEGLIQMSLQAYDQIKNVKSIKFTTNKI-EAKGKGIIDTFLIEKKRSFE 1775
>UniRef50_Q4RZV3 Cluster: Chromosome 18 SCAF14786, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 18
SCAF14786, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 576
Score = 105 bits (253), Expect = 6e-21
Identities = 55/154 (35%), Positives = 88/154 (57%), Gaps = 2/154 (1%)
Query: 910 EEFEEVSIYFSDIVGFTALAARSTAVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMV 969
+ E VSI F+DIVGFT ++A +A +V LLNDL+ FD E K+ T+GD Y
Sbjct: 400 KRMEPVSILFADIVGFTKMSANKSAPALVGLLNDLFGRFDRLCELTGCEKISTLGDCYYC 459
Query: 970 VGGLPQRTRDHAESVATMALHLLHLAGRFRVRHLPDTPLHLRIGLHTGPCCAGVVGLTMP 1029
V G P+ + DHA M L ++ +F + +T + +R+G+HTG G++G+
Sbjct: 460 VAGCPEPSADHAYCCVEMGLGMIQAIEQF-CQETRET-VSMRVGVHTGTVLCGILGMKRF 517
Query: 1030 RYCLFGDTVNTASRMESTGAAWRIQISSTTAEKL 1063
++ ++ + VN A+ ME G A ++ +S TA+ L
Sbjct: 518 KFDVWSNDVNLANLMEQLGVAGKVHLSEATAQFL 551
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.319 0.133 0.402
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 1,234,387,513
Number of Sequences: 1657284
Number of extensions: 49678301
Number of successful extensions: 171580
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 596
Number of HSP's successfully gapped in prelim test: 2656
Number of HSP's that attempted gapping in prelim test: 166683
Number of HSP's gapped (non-prelim): 4486
length of query: 1244
length of database: 575,637,011
effective HSP length: 109
effective length of query: 1135
effective length of database: 394,993,055
effective search space: 448317117425
effective search space used: 448317117425
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 78 (35.5 bits)
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