GeneModel BLAST Result against human

BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA002178-TA|BGIBMGA002178-PA|IPR001128|Cytochrome P450
         (433 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipin...   161   3e-39
M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrom...   159   1e-38
AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43...   159   1e-38
AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43...   159   1e-38
AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfami...   159   1e-38
AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43...   159   1e-38
AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfami...   159   1e-38
AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.             159   1e-38
M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA...   159   2e-38
DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family ...   159   2e-38
DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family...   159   2e-38
BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfam...   159   2e-38
BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family...   159   2e-38
AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.     159   2e-38
AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.     159   2e-38
AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450 polypep...   159   2e-38
AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4 p...   159   2e-38
M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver glu...   159   2e-38
D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.      159   2e-38
AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4 pro...   159   2e-38
X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for ...   158   3e-38
AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfami...   155   3e-37
AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.             155   3e-37
J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3 prot...   151   6e-36
BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family...   151   6e-36
AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.             151   6e-36
AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family...   150   8e-36
D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa pro...   144   4e-34
BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family...   144   4e-34
AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant...   144   4e-34
AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450 polypep...   144   4e-34
AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.     142   2e-33
BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family...   124   5e-28
AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2 pro...   124   5e-28
AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens ...   124   5e-28
AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens ...   124   5e-28
AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfami...   124   8e-28
BC041157-1|AAH41157.1|  534|Homo sapiens thromboxane A synthase ...   123   1e-27
BC014117-1|AAH14117.1|  466|Homo sapiens TBXAS1 protein protein.      123   1e-27
AK223466-1|BAD97186.1|  534|Homo sapiens thromboxane A synthase ...   123   1e-27
AF233619-1|AAF99273.1|  534|Homo sapiens thromboxane synthase pr...   123   1e-27
AF233621-1|AAF99275.1|  534|Homo sapiens thromboxane synthase pr...   123   1e-27
AF233620-1|AAF99274.1|  534|Homo sapiens thromboxane synthase pr...   123   1e-27
M80647-1|AAA60618.1|  534|Homo sapiens thromboxane synthase prot...   122   2e-27
BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.     122   2e-27
AF233625-1|AAF99279.1|  534|Homo sapiens thromboxane synthase pr...   122   2e-27
AF233622-1|AAF99276.1|  534|Homo sapiens thromboxane synthase pr...   122   2e-27
AF233618-1|AAF99272.1|  534|Homo sapiens thromboxane synthase pr...   122   2e-27
AF233617-1|AAF99271.1|  534|Homo sapiens thromboxane synthase pr...   122   2e-27
AF233616-1|AAF99270.1|  534|Homo sapiens thromboxane synthase pr...   122   2e-27
AF233615-1|AAF99269.1|  534|Homo sapiens thromboxane synthase pr...   122   2e-27
D34625-1|BAA07011.1|  533|Homo sapiens thromboxane synthase prot...   122   2e-27
AF233624-1|AAF99278.1|  534|Homo sapiens thromboxane synthase pr...   122   3e-27
AF233623-1|AAF99277.1|  534|Homo sapiens thromboxane synthase pr...   121   4e-27
AF133298-1|AAD49566.1|  520|Homo sapiens cytochrome P450 protein.     116   2e-25
U02388-1|AAC50052.2|  520|Homo sapiens cytochrome P450 4F2 protein.   113   2e-24
AY792513-1|AAV40834.1|  520|Homo sapiens cytochrome P450, family...   112   3e-24
AF054821-1|AAC08589.1|  520|Homo sapiens cytochrome P-450 protein.    112   3e-24
BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family...   111   3e-24
AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxyl...   111   3e-24
D12620-1|BAA02144.1|  520|Homo sapiens cytochrome P-450LTBV prot...   111   6e-24
AF236085-1|AAG15889.1|  524|Homo sapiens CYP4F11 protein.             111   6e-24
AB002461-1|BAA25991.1|  520|Homo sapiens leukotriene B4 omega-hy...   111   6e-24
AB002454-1|BAA25990.1|  520|Homo sapiens leukotriene B4 omega-hy...   111   6e-24
BC067440-1|AAH67440.1|  520|Homo sapiens cytochrome P450, family...   110   8e-24
BC016853-1|AAH16853.1|  524|Homo sapiens CYP4F11 protein protein.     110   8e-24
AB015306-1|BAA75823.1|  520|Homo sapiens Leukotriene B4 omega-hy...   110   8e-24
D26480-1|BAA05490.1|  520|Homo sapiens leukotriene B4 omega-hydr...   110   1e-23
BC067439-1|AAH67439.1|  520|Homo sapiens cytochrome P450, family...   110   1e-23
BC067437-1|AAH67437.1|  520|Homo sapiens cytochrome P450, family...   110   1e-23
AF467894-1|AAL67578.1|  520|Homo sapiens cytochrome P450, subfam...   110   1e-23
AC005336-1|AAC27730.1|  520|Homo sapiens CYP4F2 protein.              110   1e-23
BC035350-1|AAH35350.1|  524|Homo sapiens cytochrome P450, family...   109   2e-23
AY358977-1|AAQ89336.1|  524|Homo sapiens CYP4F12 protein.             109   2e-23
AY008841-1|AAG33247.1|  524|Homo sapiens cytochrome P450 isoform...   109   2e-23
AC004523-1|AAC11543.1|  458|Homo sapiens F22329_1 protein.            109   2e-23
AB035131-1|BAB18270.1|  524|Homo sapiens cytochrome P450 protein.     109   2e-23
AB035130-1|BAB18269.1|  524|Homo sapiens cytochrome P450 protein.     109   2e-23
BC093896-1|AAH93896.1|  531|Homo sapiens cytochrome P450, family...   107   8e-23
BC093894-1|AAH93894.1|  531|Homo sapiens cytochrome P450, family...   107   8e-23
BC069351-1|AAH69351.1|  531|Homo sapiens cytochrome P450, family...   107   8e-23
AK096820-1|BAC04868.1|  531|Homo sapiens protein ( Homo sapiens ...   107   8e-23
L13286-1|AAA62379.1|  513|Homo sapiens 1,25-dihydroxyvitamin D3 ...   104   7e-22
S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D 24-hy...   103   2e-21
AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylas...   103   2e-21
AL138805-3|CAB91829.1|  514|Homo sapiens cytochrome P450, family...   103   2e-21
AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family...   103   2e-21
BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family...    94   8e-19
AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.      94   8e-19
AK090886-1|BAC03539.1|  337|Homo sapiens protein ( Homo sapiens ...    94   1e-18
S67581-1|AAB29503.1|  591|Homo sapiens fatty acid omega-hydroxyl...    93   1e-18
S67580-1|AAB29502.1|  519|Homo sapiens fatty acid omega-hydroxyl...    93   1e-18
AY358631-1|AAQ88994.1|  505|Homo sapiens EPSW3060 protein.             93   1e-18
AY280372-1|AAQ21368.1|  519|Homo sapiens cytochrome P450 4A22 pr...    93   1e-18
AY262056-1|AAO89257.1|  505|Homo sapiens cytochrome P450 protein.      93   1e-18
AL450996-2|CAH71036.1|  505|Homo sapiens cytochrome P450, family...    93   1e-18
AL135960-6|CAI19734.1|  505|Homo sapiens cytochrome P450, family...    93   1e-18
AY280371-1|AAQ21367.1|  519|Homo sapiens cytochrome P450 4A22K p...    93   2e-18
AL135960-10|CAI19737.1|  519|Homo sapiens cytochrome P450, famil...    93   2e-18
AF208532-1|AAF76722.1|  519|Homo sapiens fatty acid omega-hydrox...    93   2e-18
L04751-1|AAA58436.1|  519|Homo sapiens cytochrome P450 protein.        92   3e-18
D26481-1|BAA05491.1|  519|Homo sapiens fatty acids omega-hydroxy...    92   3e-18
AY369778-1|AAQ56847.1|  519|Homo sapiens cytochrome P450, family...    92   3e-18
AL731892-3|CAH72778.1|  519|Homo sapiens cytochrome P450, family...    92   3e-18
BC028102-1|AAH28102.1|  509|Homo sapiens cytochrome P450, family...    91   7e-18
AY358537-1|AAQ88901.1|  509|Homo sapiens EFSW1929 protein.             91   7e-18
AM040940-1|CAJ13826.1|  509|Homo sapiens cytochrome P450 protein.      91   7e-18
AL450996-1|CAH71035.1|  509|Homo sapiens cytochrome P450, family...    91   7e-18
AK098065-1|BAC05226.1|  509|Homo sapiens protein ( Homo sapiens ...    91   7e-18
AK091806-1|BAC03751.1|  444|Homo sapiens protein ( Homo sapiens ...    91   7e-18
M80646-1|AAA60617.1|  460|Homo sapiens thromboxane synthase prot...    91   9e-18
AK131355-1|BAD18508.1|  508|Homo sapiens protein ( Homo sapiens ...    91   9e-18
AF525488-1|AAO16078.1|  519|Homo sapiens cytochrome P450, subfam...    91   9e-18
AJ563378-3|CAD91347.1|  173|Homo sapiens hypothetical protein pr...    90   2e-17
AJ563378-2|CAD91647.1|  160|Homo sapiens cytochrome P450 protein.      90   2e-17
D13705-1|BAA02864.1|  521|Homo sapiens fatty acid omega-hydroxyl...    89   2e-17
M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.                  88   5e-17
M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.                  88   5e-17
M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.                  88   5e-17
M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.                  88   5e-17
DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family...    88   5e-17
BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family...    88   5e-17
BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family...    88   5e-17
BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family...    88   5e-17
AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family...    88   5e-17
X16699-1|CAA34672.1|  511|Homo sapiens protein ( Human mRNA for ...    87   2e-16
J02871-1|AAA35712.1|  511|Homo sapiens protein ( Human lung cyto...    87   2e-16
DQ518907-1|ABF47106.1|  511|Homo sapiens cytochrome P450, family...    87   2e-16
BC017758-1|AAH17758.1|  512|Homo sapiens cytochrome P450, family...    87   2e-16
AY151049-1|AAN72312.1|  497|Homo sapiens pulmonary cytochrome P4...    87   2e-16
AY151048-1|AAN72311.1|  512|Homo sapiens pulmonary cytochrome P4...    87   2e-16
AY064485-1|AAL57720.1|  511|Homo sapiens cytochrome P450 protein.      87   2e-16
AL593856-7|CAI16983.1|  497|Homo sapiens cytochrome P450, family...    87   2e-16
AL593856-6|CAI16982.1|  512|Homo sapiens cytochrome P450, family...    87   2e-16
AL593856-5|CAI16981.1|  511|Homo sapiens cytochrome P450, family...    87   2e-16
AL356793-4|CAI22559.1|  511|Homo sapiens cytochrome P450, family...    87   2e-16
AL356793-3|CAI22557.1|  512|Homo sapiens cytochrome P450, family...    87   2e-16
AL356793-2|CAI22558.1|  497|Homo sapiens cytochrome P450, family...    87   2e-16
AF491285-1|AAM09532.1|  511|Homo sapiens cytochrome P450 protein.      87   2e-16
AY064486-1|AAL57721.1|  511|Homo sapiens cytochrome P450 protein.      86   2e-16
BC100982-1|AAI00983.1|  280|Homo sapiens CYP3A43 protein protein.      86   3e-16
U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450 monooxyge...    84   1e-15
BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family...    84   1e-15
AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family...    84   1e-15
AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.      84   1e-15
AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2 pro...    82   3e-15
AY288916-1|AAP31972.1|  508|Homo sapiens cytochrome P450, family...    82   4e-15
AF256213-1|AAG00416.1|  508|Homo sapiens 25- hydroxyvitamin D-1-...    82   4e-15
AF246895-1|AAF64299.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...    82   4e-15
AF027152-1|AAC51854.1|  508|Homo sapiens P450 25-hydroxyvitamin ...    82   4e-15
AF020192-1|AAC51853.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...    82   4e-15
AB006987-1|BAA23418.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...    82   4e-15
AB005990-1|BAA22657.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...    82   4e-15
AB005989-1|BAA22656.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...    82   4e-15
AB005038-1|BAA23416.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...    82   4e-15
AY178622-1|AAO21126.1|  531|Homo sapiens steroid hydroxylase pro...    79   4e-14
M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.             78   7e-14
AL135960-9|CAI19736.1|  421|Homo sapiens cytochrome P450, family...    78   7e-14
X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase...    77   9e-14
M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase pro...    77   9e-14
L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.        77   9e-14
BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family...    77   9e-14
BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family...    77   9e-14
AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family...    77   9e-14
AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family...    77   9e-14
AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family...    77   9e-14
X71480-1|CAA50586.1|  141|Homo sapiens cytochrome P450 protein.        75   4e-13
M32879-1|AAA52149.1|  503|Homo sapiens CYP11B1 protein.                75   5e-13
BC096287-1|AAH96287.1|  503|Homo sapiens cytochrome P450, family...    75   5e-13
BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family...    75   5e-13
AF478474-1|AAL84813.1|  503|Homo sapiens mutated cytochrome P-45...    75   5e-13
X55764-1|CAA39290.1|  503|Homo sapiens protein ( Human mRNA for ...    75   6e-13
BC096285-1|AAH96285.1|  574|Homo sapiens CYP11B1 protein protein.      74   9e-13
X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120...    74   1e-12
S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.       74   1e-12
M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.                74   1e-12
D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.       74   1e-12
BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family...    74   1e-12
AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family...    74   1e-12
AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family...    74   1e-12
AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family...    74   1e-12
M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.                  73   1e-12
M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.                  73   1e-12
L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxyla...    73   1e-12
J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrom...    73   1e-12
J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrom...    73   1e-12
DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family...    73   1e-12
DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1 pro...    73   1e-12
AL358613-3|CAH72804.1|  428|Homo sapiens cytochrome P450, family...    73   1e-12
AL358613-2|CAH72803.1|  497|Homo sapiens cytochrome P450, family...    73   1e-12
AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family...    73   1e-12
AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1 pro...    73   1e-12
AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1 pro...    73   1e-12
AF005418-1|AAB88881.1|  497|Homo sapiens retinoic acid hydroxyla...    73   1e-12
X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C pro...    73   2e-12
BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family...    73   2e-12
Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.                   73   3e-12
M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.             73   3e-12
M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.                  73   3e-12
M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrom...    73   3e-12
D13752-1|BAA02899.1|  503|Homo sapiens steroid 18-hydroxylase pr...    73   3e-12
BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family...    73   3e-12
BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family...    73   3e-12
BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family...    73   3e-12
BC041158-1|AAH41158.1|  455|Homo sapiens CYP4A11 protein protein.      73   3e-12
BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family...    73   3e-12
AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family...    73   3e-12
AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13 va...    73   3e-12
AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13 va...    73   3e-12
AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13 va...    73   3e-12
AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13 va...    73   3e-12
AL731892-4|CAH72779.1|  455|Homo sapiens cytochrome P450, family...    73   3e-12
AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family...    73   3e-12
AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family...    73   3e-12
AL135960-11|CAI19738.1|  455|Homo sapiens cytochrome P450, famil...    73   3e-12
AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13 pr...    73   3e-12
M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.                  72   3e-12
L36085-1|AAC01761.1|  441|Homo sapiens thromboxane A2 synthase p...    72   3e-12
BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family...    72   3e-12
X54741-1|CAA38539.1|  503|Homo sapiens aldosterone  synthase (P-...    72   5e-12
U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.        72   5e-12
M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.                  72   5e-12
M32881-1|AAA35741.1|  503|Homo sapiens protein ( Human steroid 1...    71   6e-12
AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13 va...    71   6e-12
U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.        71   8e-12
BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family...    71   8e-12
BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family...    71   8e-12
AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1 pro...    71   8e-12
AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family...    71   8e-12
X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mR...    71   1e-11
X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is ...    71   1e-11
M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.                  71   1e-11
M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.                  71   1e-11
L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18 prot...    71   1e-11
BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family...    71   1e-11
BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family...    71   1e-11
BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family...    71   1e-11
BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family...    71   1e-11
BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family...    71   1e-11
AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6 pro...    71   1e-11
DQ680079-1|ABG25922.1|  347|Homo sapiens truncated cytochrome P4...    70   2e-11
U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.        69   2e-11
AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,...    69   2e-11
X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for ...    69   3e-11
M28420-1|AAA52141.1|  419|Homo sapiens cytochrome P-450 aromatas...    69   4e-11
J04127-1|AAA52132.1|  503|Homo sapiens CYP19 protein.                  69   4e-11
Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for ...    68   6e-11
X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for ...    68   6e-11
M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase...    68   6e-11
M22246-1|AAA35557.1|  503|Homo sapiens protein ( Human aromatase...    68   6e-11
M18856-1|AAA35556.1|  419|Homo sapiens protein ( Human aromatase...    68   6e-11
DQ118405-1|AAZ23558.1|  503|Homo sapiens cytochrome P450 subfami...    68   6e-11
BC107785-1|AAI07786.1|  503|Homo sapiens cytochrome P450, family...    68   6e-11
BC035959-1|AAH35959.1|  503|Homo sapiens cytochrome P450, family...    68   6e-11
AY957953-1|AAX44046.1|  503|Homo sapiens cytochrome P450, family...    68   6e-11
M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant 21...    66   2e-10
M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human 21-hydrox...    66   2e-10
M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.                  66   2e-10
M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.                 66   2e-10
BX679671-8|CAM26071.1|  464|Homo sapiens cytochrome P450, family...    66   2e-10
BX679671-7|CAM26070.1|  494|Homo sapiens cytochrome P450, family...    66   2e-10
BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family...    66   2e-10
BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family...    66   2e-10
BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family...    66   2e-10
AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,...    66   2e-10
AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,...    66   2e-10
AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,...    66   2e-10
AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,...    66   2e-10
AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,...    66   2e-10
AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,...    66   2e-10
AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,...    66   2e-10
AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family...    66   2e-10
AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family...    66   2e-10
AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, famil...    66   2e-10
AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, famil...    66   2e-10
AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, famil...    66   2e-10
AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, famil...    66   2e-10
AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P4...    66   2e-10
AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450 21-hydr...    66   2e-10
AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450 21-hydr...    66   2e-10
M29874-1|AAA52144.1|  491|Homo sapiens CYP2B protein.                  66   3e-10
DQ298753-1|ABB84469.1|  491|Homo sapiens cytochrome P450, family...    66   3e-10
BC067431-1|AAH67431.1|  491|Homo sapiens cytochrome P450, family...    66   3e-10
BC067430-1|AAH67430.1|  491|Homo sapiens cytochrome P450, family...    66   3e-10
AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens ...    66   3e-10
AF182277-1|AAF13602.1|  491|Homo sapiens cytochrome P450-2B6 pro...    66   3e-10
AC023172-1|AAF32444.1|  491|Homo sapiens CYP2B6 protein.               66   3e-10
M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoqu...    65   4e-10
M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.     65   4e-10
DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6 pro...    65   4e-10
CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.               65   4e-10
BX538127-1|CAD98029.1|  310|Homo sapiens hypothetical protein pr...    65   4e-10
BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family...    65   4e-10
BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family...    65   4e-10
BC096260-1|AAH96260.1|  431|Homo sapiens CYP2C18 protein protein.      65   4e-10
BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family...    65   4e-10
BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.       65   4e-10
AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxyl...    65   4e-10
J02906-1|AAA52156.1|  491|Homo sapiens CYP2F1 protein.                 64   7e-10
AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase ...    64   7e-10
X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.    64   9e-10
M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.                  64   9e-10
DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6 pro...    64   9e-10
BC109205-1|AAI09206.1|  512|Homo sapiens cytochrome P450, family...    64   9e-10
BC069443-1|AAH69443.1|  512|Homo sapiens cytochrome P450, family...    64   9e-10
AF252297-1|AAF76003.1|  512|Homo sapiens cytochrome P450 retinoi...    64   9e-10
AC007002-1|AAY14690.1|  512|Homo sapiens unknown protein.              64   9e-10
M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6 prot...    64   1e-09
DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6 pro...    64   1e-09
DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6 pro...    64   1e-09
DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6 pro...    64   1e-09
DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6 pro...    64   1e-09
DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6 pro...    64   1e-09
BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family...    64   1e-09
BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family...    64   1e-09
AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6 prot...    64   1e-09
X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase ...    63   2e-09
U23942-1|AAB39951.1|  509|Homo sapiens lanosterol 14-demethylase...    63   2e-09
M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase pr...    63   2e-09
D55653-1|BAA09512.1|  509|Homo sapiens lanosterol 14-demethylase...    63   2e-09
AC000120-2|AAB46356.1|  509|Homo sapiens unknown protein.              63   2e-09
U51692-1|AAC50951.1|  503|Homo sapiens lanosterol 14-alpha demet...    62   3e-09
BC032322-1|AAH32322.1|  509|Homo sapiens cytochrome P450, family...    62   3e-09
AF372573-1|AAL69652.1|  495|Homo sapiens cytochrome P450 2F1 pro...    62   3e-09
BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family...    62   5e-09
AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1 var...    62   5e-09
M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.                  61   6e-09
DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6 pro...    61   6e-09
X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.                60   1e-08
EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family...    60   1e-08
BC039307-1|AAH39307.1|  372|Homo sapiens FLJ16008 protein protein.     60   1e-08
BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family...    60   1e-08
AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1 pro...    60   1e-08
AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family...    60   1e-08
AK131190-1|BAD18388.1|  372|Homo sapiens .-.-).  protein.              60   1e-08
AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.      60   1e-08
X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.    60   1e-08
K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.                 60   1e-08
L00389-1|AAA35738.1|  516|Homo sapiens protein ( Human cytochrom...    59   3e-08
Z00036-1|CAA77335.1|  515|Homo sapiens protein ( Human mRNA for ...    59   3e-08
M55053-1|AAA52146.1|  515|Homo sapiens cytochrome P3-450 protein.      59   3e-08
M31667-1|AAA52163.1|  515|Homo sapiens CYP1A2 protein.                 59   3e-08
K03192-1|AAA52147.1|  331|Homo sapiens CYP1A1 protein.                 59   3e-08
DQ022432-1|AAY26399.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC067428-1|AAH67428.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC067426-1|AAH67426.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC067425-1|AAH67425.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
BC067424-1|AAH67424.1|  516|Homo sapiens cytochrome P450, family...    59   3e-08
AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family...    59   3e-08
AF253322-2|AAK25728.1|  516|Homo sapiens cytochrome P450 protein.      59   3e-08
AF237982-1|AAF63329.1|  469|Homo sapiens oxysterol 7alpha-hydrox...    58   5e-08
BC067427-1|AAH67427.1|  516|Homo sapiens cytochrome P450, family...    58   6e-08
AF182274-1|AAF13599.1|  516|Homo sapiens cytochrome P450-1A2 pro...    58   6e-08
X05367-1|CAA28965.1|  521|Homo sapiens desmolase protein.              58   8e-08
M28253-1|AAA36404.1|  239|Homo sapiens cytochrome P-450-scc prot...    58   8e-08
M14565-1|AAA52162.1|  521|Homo sapiens CYP11A protein.                 58   8e-08
BC032329-1|AAH32329.1|  521|Homo sapiens cytochrome P450, family...    58   8e-08
M12079-1|AAA52152.1|  191|Homo sapiens POR protein.                    57   1e-07
BC096259-1|AAH96259.1|  443|Homo sapiens CYP2C18 protein protein.      57   1e-07
BC010358-1|AAH10358.1|  469|Homo sapiens cytochrome P450, family...    57   1e-07
AC004914-2|AAP21887.1|  311|Homo sapiens unknown protein.              57   1e-07
AC004914-1|AAD21788.1|  348|Homo sapiens unknown protein.              57   1e-07
BC033691-1|AAH33691.1|  504|Homo sapiens cytochrome P450, family...    56   2e-07
AY358603-1|AAQ88966.1|  504|Homo sapiens Cytochrome p450 protein.      56   2e-07
AL591242-1|CAH73899.1|  469|Homo sapiens cytochrome P450, family...    56   2e-07
AL035670-1|CAI20276.1|  469|Homo sapiens cytochrome P450, family...    56   2e-07
AK027605-1|BAB55227.1|  564|Homo sapiens protein ( Homo sapiens ...    56   2e-07
AF335278-1|AAK13498.1|  504|Homo sapiens cytochrome P450 2S1 pro...    56   2e-07
L16883-1|AAD13467.1|  169|Homo sapiens cytochrome P-450 2C protein.    56   2e-07
M24667-1|AAA52148.1|  256|Homo sapiens steroid 11-beta-hydroxyla...    54   1e-06
AB209700-1|BAD92937.1|  336|Homo sapiens cytochrome P450, family...    54   1e-06
U56438-1|AAC50809.1|  543|Homo sapiens dioxin-inducible cytochro...    53   2e-06
BT020001-1|AAV38804.1|  543|Homo sapiens cytochrome P450, family...    53   2e-06
AY393998-1|AAQ87875.1|  543|Homo sapiens cytochrome P450, family...    53   2e-06
AF450132-1|AAM50512.1|  543|Homo sapiens cytochrome P450 CYP1B1 ...    53   2e-06
U03688-1|AAA19567.1|  543|Homo sapiens cytochrome P450 protein.        52   3e-06
M12078-1|AAA52154.1|  192|Homo sapiens POR protein.                    52   3e-06
BC012049-1|AAH12049.1|  543|Homo sapiens cytochrome P450, family...    52   3e-06
AC009229-2|AAY15039.1|  543|Homo sapiens unknown protein.              52   3e-06
M74055-1|AAA36742.1|  229|Homo sapiens thromboxane synthase prot...    52   5e-06
BT019979-1|AAV38782.1|  543|Homo sapiens cytochrome P450, family...    51   9e-06
AY220845-1|AAO49806.1|  516|Homo sapiens cytochrome P450 protein.      51   9e-06
AY359068-1|AAQ89427.1|  462|Homo sapiens P450-like protein protein.    50   2e-05
BC093022-1|AAH93022.1|  416|Homo sapiens CYP20A1 protein protein.      49   4e-05
BC033752-1|AAH33752.1|  462|Homo sapiens cytochrome P450, family...    49   4e-05
BC020616-1|AAH20616.1|  462|Homo sapiens cytochrome P450, family...    49   4e-05
AK000366-1|BAA91114.1|  408|Homo sapiens protein ( Homo sapiens ...    48   5e-05
AL358613-1|CAH72802.2|  522|Homo sapiens cytochrome P450, family...    48   6e-05
AF280111-1|AAG33012.1|  250|Homo sapiens cytochrome P450 subfami...    48   6e-05
AK127151-1|BAC86855.1|  146|Homo sapiens protein ( Homo sapiens ...    47   1e-04
BC128535-1|AAI28536.1|  143|Homo sapiens LOC283480 protein protein.    46   2e-04
BC096286-1|AAH96286.1|  437|Homo sapiens cytochrome P450, family...    46   3e-04
AF183412-1|AAG09681.1|  435|Homo sapiens cytochrome P450 monooxy...    46   3e-04
DQ016495-1|AAY34975.1|  195|Homo sapiens cytochrome P450 1B1 pro...    46   3e-04
AY356349-1|AAQ55485.1|  522|Homo sapiens cytochrome P450 protein.      46   3e-04
AM233517-1|CAJ80720.1|  175|Homo sapiens cytochrome P450 1A1 pro...    45   6e-04
BC109084-1|AAI09085.1|  448|Homo sapiens CYP24A1 protein protein.      44   8e-04
BC109083-1|AAI09084.1|  448|Homo sapiens CYP24A1 protein protein.      44   8e-04
AL138805-2|CAM27343.1|  448|Homo sapiens cytochrome P450, family...    44   8e-04
X56088-1|CAA39568.1|  504|Homo sapiens cholesterol  7-alpha-hydr...    42   0.006
M93133-1|AAA58435.1|  504|Homo sapiens cholesterol 7-alpha hydro...    42   0.006
BC112184-1|AAI12185.1|  504|Homo sapiens cytochrome P450, family...    42   0.006
BC101777-1|AAI01778.1|  504|Homo sapiens cytochrome P450, family...    42   0.006
AJ877238-1|CAI47002.1|   97|Homo sapiens putative cytochrome P45...    42   0.006
AF176805-1|AAK11850.1|  506|Homo sapiens oxysterol 7alpha-hydrox...    39   0.030
AF127090-1|AAD20021.1|  506|Homo sapiens oxysterol 7alpha-hydrox...    39   0.030
AF029403-1|AAC95426.1|  506|Homo sapiens oxysterol 7alpha-hydrox...    39   0.030
D12621-1|BAA02145.1|  389|Homo sapiens cytochrome P-450LTBV prot...    39   0.039
BC067444-1|AAH67444.1|  501|Homo sapiens cytochrome P450, family...    37   0.12 
BC067442-1|AAH67442.1|  501|Homo sapiens cytochrome P450, family...    37   0.12 
AM233518-1|CAJ80721.1|  157|Homo sapiens cytochrome P450 1A1 pro...    37   0.12 
AF090320-1|AAD19877.1|  501|Homo sapiens sterol 12-alpha-hydroxy...    37   0.12 
AF090318-1|AAC63037.1|  462|Homo sapiens sterol 12-alpha hydroxy...    37   0.12 
BC067441-1|AAH67441.1|  501|Homo sapiens cytochrome P450, family...    36   0.21 
BC067434-1|AAH67434.1|  501|Homo sapiens cytochrome P450, family...    36   0.21 
AJ563379-2|CAD91649.1|   84|Homo sapiens cytochrome P450 protein.      36   0.21 
AY871801-1|AAX62803.1|  483|Homo sapiens cytochrome P450 family ...    36   0.37 
AF144566-1|AAD30164.1|  339|Homo sapiens cytochrome P450 epoxyge...    36   0.37 
AK127234-1|BAC86895.1|  130|Homo sapiens ).  protein.                  35   0.49 
AF040259-1|AAD10199.1|  144|Homo sapiens cytochrome P450 1A1 pro...    35   0.64 
AC011737-1|AAX88915.1|  382|Homo sapiens unknown protein.              35   0.64 
AF297052-1|AAG31785.1|  500|Homo sapiens prostacyclin synthase p...    34   1.1  
M17398-1|AAA35740.1|  393|Homo sapiens protein ( Human cytochrom...    32   3.4  
BC029155-1|AAH29155.1|  489|Homo sapiens Unknown (protein for IM...    32   3.4  
D84124-1|BAA28219.1|  509|Homo sapiens prostacyclin synthase pro...    32   4.5  
D83402-1|BAA11910.1|  500|Homo sapiens prostacyclin synthase pro...    32   4.5  
D38145-1|BAA07343.1|  500|Homo sapiens prostacyclin synthase pro...    32   4.5  
BC101811-1|AAI01812.1|  500|Homo sapiens prostaglandin I2 (prost...    32   4.5  
BC101809-1|AAI01810.1|  500|Homo sapiens prostaglandin I2 (prost...    32   4.5  
AL118525-1|CAC14162.1|  500|Homo sapiens prostaglandin I2 (prost...    32   4.5  
AF297051-1|AAG31784.1|  500|Homo sapiens prostacyclin synthase p...    32   4.5  
AF297050-1|AAG31783.1|  500|Homo sapiens prostacyclin synthase p...    32   4.5  
AF297049-1|AAG31782.1|  500|Homo sapiens prostacyclin synthase p...    32   4.5  
AF297048-1|AAG31781.1|  500|Homo sapiens prostacyclin synthase p...    32   4.5  
X58904-1|CAA41707.1|  371|Homo sapiens steroid 21-monooxygenase ...    31   6.0  
X58902-1|CAA41706.1|  372|Homo sapiens steroid 21-monooxygenase ...    31   6.0  
X58900-1|CAA41704.1|  372|Homo sapiens steroid 21-monooxygenase ...    31   6.0  
X58899-1|CAA41703.1|  368|Homo sapiens steroid 21-monooxygenase ...    31   6.0  
X58898-1|CAA41702.1|  371|Homo sapiens steroid 21-monooxygenase ...    31   6.0  
U39231-1|AAA84418.1|  466|Homo sapiens GIP receptor protein.           31   7.9  
D49559-1|BAA08503.1|  466|Homo sapiens gastric inhibitory polype...    31   7.9  
BC101673-1|AAI01674.1|  466|Homo sapiens gastric inhibitory poly...    31   7.9  
BC095494-1|AAH95494.1|  465|Homo sapiens GIPR protein protein.         31   7.9  
BC093723-1|AAH93723.1|  466|Homo sapiens gastric inhibitory poly...    31   7.9  
AC006132-1|AAC97984.1|  466|Homo sapiens GIPR_HUMAN protein.           31   7.9  

>J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipine
           oxidase protein.
          Length = 502

 Score =  161 bits (392), Expect = 3e-39
 Identities = 118/405 (29%), Positives = 209/405 (51%), Gaps = 25/405 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGTFPRLIKWLDMMN---FDNYETSFI- 181
           ++D  N    P +  T+K L      +  FFL+  FP LI  L+++N   F    T+F+ 
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSIIFPFLIPILEVLNICVFPREVTNFLR 249

Query: 182 DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L          
Sbjct: 250 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIFA 304

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET+
Sbjct: 305 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNETL 363

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ +
Sbjct: 364 RLFPIAMRLERVCKKDVEI--NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKK 421

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           N + I+ +++ PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 NKDNIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466


>M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrome
           P-450 nifedipine oxidase mRNA, complet cds. ).
          Length = 503

 Score =  159 bits (387), Expect = 1e-38
 Identities = 119/406 (29%), Positives = 210/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ +++ PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43.1
           protein.
          Length = 503

 Score =  159 bits (387), Expect = 1e-38
 Identities = 114/418 (27%), Positives = 209/418 (50%), Gaps = 24/418 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P +++ D   I+ VL  +  S  +  + L     L  ++ F +D   WK +R  LSP
Sbjct: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED-EEWKRIRTLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFI-ENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGVDV 128
           AF+S++ K M   I +     V  + + + N + +    F   Y  T   I   +FGV++
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAY--TMDVITGTLFGVNL 193

Query: 129 DQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFI-D 182
           D  N    P L   +K L+  L  +  F L    FP L    + +N   F    T F+ +
Sbjct: 194 DSLNNPQDPFLKNMKKLLK--LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251

Query: 183 AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
           +++++ E+R   ++++  DF    ++ QN +  +          +D  L           
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKS-----HKALSDLELVAQSIIIIFAA 306

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLR 365

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+RF+ +N
Sbjct: 366 LFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKN 423

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP--QDYKPVKFERSP 416
            + I+ + ++PFG G R CIG +FA   ++  +   L+ ++  P  +   P+K +  P
Sbjct: 424 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43.3
           protein.
          Length = 503

 Score =  159 bits (387), Expect = 1e-38
 Identities = 114/418 (27%), Positives = 209/418 (50%), Gaps = 24/418 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P +++ D   I+ VL  +  S  +  + L     L  ++ F +D   WK +R  LSP
Sbjct: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED-EEWKRIRTLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFI-ENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGVDV 128
           AF+S++ K M   I +     V  + + + N + +    F   Y  T   I   +FGV++
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAY--TMDVITGTLFGVNL 193

Query: 129 DQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFI-D 182
           D  N    P L   +K L+  L  +  F L    FP L    + +N   F    T F+ +
Sbjct: 194 DSLNNPQDPFLKNMKKLLK--LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251

Query: 183 AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
           +++++ E+R   ++++  DF    ++ QN +  +          +D  L           
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKS-----HKALSDLELVAQSIIIIFAA 306

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLAN-KAPVTYDALVQMEYLDMVVNETLR 365

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+RF+ +N
Sbjct: 366 LFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKN 423

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP--QDYKPVKFERSP 416
            + I+ + ++PFG G R CIG +FA   ++  +   L+ ++  P  +   P+K +  P
Sbjct: 424 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score =  159 bits (387), Expect = 1e-38
 Identities = 114/418 (27%), Positives = 209/418 (50%), Gaps = 24/418 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P +++ D   I+ VL  +  S  +  + L     L  ++ F +D   WK +R  LSP
Sbjct: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED-EEWKRIRTLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFI-ENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGVDV 128
           AF+S++ K M   I +     V  + + + N + +    F   Y  T   I   +FGV++
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAY--TMDVITGTLFGVNL 193

Query: 129 DQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFI-D 182
           D  N    P L   +K L+  L  +  F L    FP L    + +N   F    T F+ +
Sbjct: 194 DSLNNPQDPFLKNMKKLLK--LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251

Query: 183 AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
           +++++ E+R   ++++  DF    ++ QN +  +          +D  L           
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKS-----HKALSDLELVAQSIIIIFAA 306

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLR 365

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+RF+ +N
Sbjct: 366 LFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKN 423

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP--QDYKPVKFERSP 416
            + I+ + ++PFG G R CIG +FA   ++  +   L+ ++  P  +   P+K +  P
Sbjct: 424 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43
           protein.
          Length = 503

 Score =  159 bits (387), Expect = 1e-38
 Identities = 114/418 (27%), Positives = 209/418 (50%), Gaps = 24/418 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P +++ D   I+ VL  +  S  +  + L     L  ++ F +D   WK +R  LSP
Sbjct: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED-EEWKRIRTLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFI-ENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGVDV 128
           AF+S++ K M   I +     V  + + + N + +    F   Y  T   I   +FGV++
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAY--TMDVITGTLFGVNL 193

Query: 129 DQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFI-D 182
           D  N    P L   +K L+  L  +  F L    FP L    + +N   F    T F+ +
Sbjct: 194 DSLNNPQDPFLKNMKKLLK--LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251

Query: 183 AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
           +++++ E+R   ++++  DF    ++ QN +  +          +D  L           
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKS-----HKALSDLELVAQSIIIIFAA 306

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLR 365

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+RF+ +N
Sbjct: 366 LFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKN 423

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP--QDYKPVKFERSP 416
            + I+ + ++PFG G R CIG +FA   ++  +   L+ ++  P  +   P+K +  P
Sbjct: 424 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 503

 Score =  159 bits (387), Expect = 1e-38
 Identities = 114/418 (27%), Positives = 209/418 (50%), Gaps = 24/418 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P +++ D   I+ VL  +  S  +  + L     L  ++ F +D   WK +R  LSP
Sbjct: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED-EEWKRIRTLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFI-ENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGVDV 128
           AF+S++ K M   I +     V  + + + N + +    F   Y  T   I   +FGV++
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAY--TMDVITGTLFGVNL 193

Query: 129 DQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFI-D 182
           D  N    P L   +K L+  L  +  F L    FP L    + +N   F    T F+ +
Sbjct: 194 DSLNNPQDPFLKNMKKLLK--LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251

Query: 183 AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
           +++++ E+R   ++++  DF    ++ QN +  +          +D  L           
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKS-----HKALSDLELVAQSIIIIFAA 306

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLR 365

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+RF+ +N
Sbjct: 366 LFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKN 423

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP--QDYKPVKFERSP 416
            + I+ + ++PFG G R CIG +FA   ++  +   L+ ++  P  +   P+K +  P
Sbjct: 424 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.
          Length = 503

 Score =  159 bits (387), Expect = 1e-38
 Identities = 114/418 (27%), Positives = 209/418 (50%), Gaps = 24/418 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P +++ D   I+ VL  +  S  +  + L     L  ++ F +D   WK +R  LSP
Sbjct: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED-EEWKRIRTLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFI-ENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGVDV 128
           AF+S++ K M   I +     V  + + + N + +    F   Y  T   I   +FGV++
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAY--TMDVITGTLFGVNL 193

Query: 129 DQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFI-D 182
           D  N    P L   +K L+  L  +  F L    FP L    + +N   F    T F+ +
Sbjct: 194 DSLNNPQDPFLKNMKKLLK--LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251

Query: 183 AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
           +++++ E+R   ++++  DF    ++ QN +  +          +D  L           
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKS-----HKALSDLELVAQSIIIIFAA 306

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLR 365

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+RF+ +N
Sbjct: 366 LFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKN 423

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP--QDYKPVKFERSP 416
            + I+ + ++PFG G R CIG +FA   ++  +   L+ ++  P  +   P+K +  P
Sbjct: 424 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA
           encoding nifedipine oxidase, complete cds. ).
          Length = 503

 Score =  159 bits (386), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family 3
           subfamily A polypeptide 4 protein.
          Length = 503

 Score =  159 bits (386), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score =  159 bits (386), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfamily
           IIIA, polypeptide 4 protein.
          Length = 503

 Score =  159 bits (386), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score =  159 bits (386), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.
          Length = 430

 Score =  159 bits (386), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 4   GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 62

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 63  TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 118

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 119 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 176

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 177 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 231

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 232 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 290

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 291 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 348

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 349 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 394


>AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.
          Length = 503

 Score =  159 bits (386), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450
           polypeptide 4 protein.
          Length = 503

 Score =  159 bits (386), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4
           protein.
          Length = 503

 Score =  159 bits (386), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver
           glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
           complete cds. ).
          Length = 504

 Score =  159 bits (385), Expect = 2e-38
 Identities = 118/404 (29%), Positives = 210/404 (51%), Gaps = 21/404 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKLVLVKECYSVFTNREPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I ++ FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDV-FGA---YSMDVITSSSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           +VD  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NVDSLNNPQDPLVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
             AVK++ E+R    +++    + L + +H+  ++  +   +  +D  L           
Sbjct: 250 RKAVKRMKESRLEDTQKHRVDFLQLMIDSHKNSKETESHKAL--SDLELVAQSIIFIFAG 307

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET+R
Sbjct: 308 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNETLR 366

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ +N
Sbjct: 367 LFPIAMRLERVCKKDVEI--NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 424

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
            + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 425 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 468


>D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.
          Length = 504

 Score =  159 bits (385), Expect = 2e-38
 Identities = 118/404 (29%), Positives = 210/404 (51%), Gaps = 21/404 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKLVLVKECYSVFTNREPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I ++ FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRRERETGKPVTLKDV-FGA---YSMDVITSSSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           +VD  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NVDSLNNPQDPLVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
             AVK++ E+R    +++    + L + +H+  ++  +   +  +D  L           
Sbjct: 250 RKAVKRMKESRLEDTQKHRVDFLQLMIDSHKNSKETESHKAL--SDLELVAQSIIFIFAG 307

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET+R
Sbjct: 308 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNETLR 366

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ +N
Sbjct: 367 LFPIAMRLERVCKKDVEI--NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 424

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
            + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 425 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 468


>AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4
           protein.
          Length = 503

 Score =  159 bits (385), Expect = 2e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGCETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for
           cytochrome P-450 (cyp3 locus). ).
          Length = 503

 Score =  158 bits (384), Expect = 3e-38
 Identities = 119/406 (29%), Positives = 209/406 (51%), Gaps = 26/406 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P + + D   I+ VL  +  S  +          +  +I   +D   WK LR  LSP
Sbjct: 77  GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK M   I +     V  +     +G    L+++ F A   Y+   I +  FGV
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV-FGA---YSMDVITSTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMMN---FDNYETSFI 181
           ++D  N    P +  T+K L      +  FFL+ T FP LI  L+++N   F    T+F+
Sbjct: 192 NIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249

Query: 182 -DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +VK++ E+R    +++  DF+ + ++ QN +      T      +D  L         
Sbjct: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALSDLELVAQSIIFIF 304

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              +TT++V+ F + EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET
Sbjct: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNET 363

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
           +R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++ + + F P+RF+ 
Sbjct: 364 LRLFPIAMRLERVCKKDVEI--NGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 504

 Score =  155 bits (376), Expect = 3e-37
 Identities = 114/419 (27%), Positives = 209/419 (49%), Gaps = 25/419 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P +++ D   I+ VL  +  S  +  + L     L  ++ F +D   WK +R  LSP
Sbjct: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED-EEWKRIRTLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFI-ENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGVDV 128
           AF+S++ K M   I +     V  + + + N + +    F   Y  T   I   +FGV++
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAY--TMDVITGTLFGVNL 193

Query: 129 DQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFI-D 182
           D  N    P L   +K L+  L  +  F L    FP L    + +N   F    T F+ +
Sbjct: 194 DSLNNPQDPFLKNMKKLLK--LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251

Query: 183 AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
           +++++ E+R   ++++  DF    ++ QN +  +          +D  L           
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKS-----HKALSDLELVAQSIIIIFAA 306

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLR 365

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQ-RFAPE 359
            +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+ RF+ +
Sbjct: 366 LFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKK 423

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP--QDYKPVKFERSP 416
           N + I+ + ++PFG G R CIG +FA   ++  +   L+ ++  P  +   P+K +  P
Sbjct: 424 NKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 482


>AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.
          Length = 504

 Score =  155 bits (376), Expect = 3e-37
 Identities = 114/419 (27%), Positives = 209/419 (49%), Gaps = 25/419 (5%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P +++ D   I+ VL  +  S  +  + L     L  ++ F +D   WK +R  LSP
Sbjct: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED-EEWKRIRTLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFI-ENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGVDV 128
           AF+S++ K M   I +     V  + + + N + +    F   Y  T   I   +FGV++
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAY--TMDVITGTLFGVNL 193

Query: 129 DQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFI-D 182
           D  N    P L   +K L+  L  +  F L    FP L    + +N   F    T F+ +
Sbjct: 194 DSLNNPQDPFLKNMKKLLK--LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251

Query: 183 AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
           +++++ E+R   ++++  DF    ++ QN +  +          +D  L           
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKS-----HKALSDLELVAQSIIIIFAA 306

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLR 365

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQ-RFAPE 359
            +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+ RF+ +
Sbjct: 366 LFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKK 423

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP--QDYKPVKFERSP 416
           N + I+ + ++PFG G R CIG +FA   ++  +   L+ ++  P  +   P+K +  P
Sbjct: 424 NKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 482


>J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3
           protein.
          Length = 502

 Score =  151 bits (365), Expect = 6e-36
 Identities = 117/405 (28%), Positives = 200/405 (49%), Gaps = 25/405 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G+ P + + D   I+ VL  +  S  +    L     +  +I   +D   WK +R  LSP
Sbjct: 77  GQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAED-EEWKRIRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIENS---GNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK MF  I +     V  +      G    L+++ F A   Y+   I    FGV
Sbjct: 136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI-FGA---YSMDVITGTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKAL-----EPTLKSIMTF-FLAGTFPRLIKWLDMMNFDNYETS 179
           ++D  N    P +  T+K L     +P   SI+ F FL   F  L   L   +  N+ + 
Sbjct: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +KK   N +  + + DF+ + ++ QN +      T      +D  L          
Sbjct: 252 SVNRMKKSRLNDKQ-KHRLDFLQLMIDSQNSKE-----TESHKALSDLELAAQSIIFIFA 305

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT++V+ FTL EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET+
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETL 364

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R +P    L+R C K+  +  N + I K ++ V+P  ALH D +++ + + F P+RF+ +
Sbjct: 365 RLFPVAIRLERTCKKDVEI--NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
             + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 423 K-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466


>BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 protein.
          Length = 502

 Score =  151 bits (365), Expect = 6e-36
 Identities = 117/405 (28%), Positives = 200/405 (49%), Gaps = 25/405 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G+ P + + D   I+ VL  +  S  +    L     +  +I   +D   WK +R  LSP
Sbjct: 77  GQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAED-EEWKRIRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIENS---GNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK MF  I +     V  +      G    L+++ F A   Y+   I    FGV
Sbjct: 136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI-FGA---YSMDVITGTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKAL-----EPTLKSIMTF-FLAGTFPRLIKWLDMMNFDNYETS 179
           ++D  N    P +  T+K L     +P   SI+ F FL   F  L   L   +  N+ + 
Sbjct: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +KK   N +  + + DF+ + ++ QN +      T      +D  L          
Sbjct: 252 SVNRMKKSRLNDKQ-KHRLDFLQLMIDSQNSKE-----TESHKALSDLELAAQSIIFIFA 305

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT++V+ FTL EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET+
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETL 364

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R +P    L+R C K+  +  N + I K ++ V+P  ALH D +++ + + F P+RF+ +
Sbjct: 365 RLFPVAIRLERTCKKDVEI--NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
             + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 423 K-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466


>AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.
          Length = 502

 Score =  151 bits (365), Expect = 6e-36
 Identities = 117/405 (28%), Positives = 200/405 (49%), Gaps = 25/405 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G+ P + + D   I+ VL  +  S  +    L     +  +I   +D   WK +R  LSP
Sbjct: 77  GQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAED-EEWKRIRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIENS---GNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK MF  I +     V  +      G    L+++ F A   Y+   I    FGV
Sbjct: 136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI-FGA---YSMDVITGTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKAL-----EPTLKSIMTF-FLAGTFPRLIKWLDMMNFDNYETS 179
           ++D  N    P +  T+K L     +P   SI+ F FL   F  L   L   +  N+ + 
Sbjct: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +KK   N +  + + DF+ + ++ QN +      T      +D  L          
Sbjct: 252 SVNRMKKSRLNDKQ-KHRLDFLQLMIDSQNSKE-----TESHKALSDLELAAQSIIFIFA 305

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT++V+ FTL EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET+
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETL 364

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R +P    L+R C K+  +  N + I K ++ V+P  ALH D +++ + + F P+RF+ +
Sbjct: 365 RLFPVAIRLERTCKKDVEI--NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
             + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 423 K-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466


>AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 variant protein.
          Length = 502

 Score =  150 bits (364), Expect = 8e-36
 Identities = 117/405 (28%), Positives = 200/405 (49%), Gaps = 25/405 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G+ P + + D   I+ VL  +  S  +    L     +  +I   +D   WK +R  LSP
Sbjct: 77  GQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAED-EEWKRIRPLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIENS---GNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK MF  I +     V  +      G    L+++ F A   Y+   I    FGV
Sbjct: 136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI-FGA---YSMDVITGTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKAL-----EPTLKSIMTF-FLAGTFPRLIKWLDMMNFDNYETS 179
           ++D  N    P +  T+K L     +P   SI+ F FL   F  L   L   +  N+ + 
Sbjct: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +KK   N +  + + DF+ + ++ QN +      T      +D  L          
Sbjct: 252 SVNRMKKSRLNDKQ-KHRLDFLQLMIDSQNSKE-----TESHKALSDLELAAQSIIFIFA 305

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT++V+ FTL EL+++P V +KL  EID V  + K    ++ + + +YL+MVVNET+
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETL 364

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R +P    L+R C K+  +  N + I K ++ V+P  ALH D +++ + + F P+RF+ +
Sbjct: 365 RLFPVAIRLERTCMKDVEI--NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
             + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 423 K-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466


>D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa
           protein.
          Length = 503

 Score =  144 bits (350), Expect = 4e-34
 Identities = 116/421 (27%), Positives = 208/421 (49%), Gaps = 31/421 (7%)

Query: 11  RRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSPA 70
           ++P + + D   I+ VL  +  S  +          + ++I   +D   WK +R  LSP 
Sbjct: 78  QQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAED-EEWKRIRSLLSPT 136

Query: 71  FSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGVD 127
           F+S +LK M   I +     V  +     +G    L+ + F A   Y+   I +  FGV 
Sbjct: 137 FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHV-FGA---YSMDVITSTSFGVS 192

Query: 128 VDQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFID 182
           +D  N    P +  T+K L      +  F L+   FP L   L+ +N   F     SF+ 
Sbjct: 193 IDSLNNPQDPFVENTKKLLR--FNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLT 250

Query: 183 -AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            +VK++ E R    +++  DF+ + ++ QN    +D  T   +  +D  L          
Sbjct: 251 KSVKQIKEGRLKETQKHRVDFLQLMIDSQNS---KDSETHKAL--SDLELMAQSIIFIFA 305

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT++V+ F + EL+++P V +K+  EID V  + K    ++ + + +YL+MVVNET+
Sbjct: 306 GYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN-KAPPTYDTVLQLEYLDMVVNETL 364

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R +P    L+R+C K+  +  N + I K  + ++P   LH D +++ + + F P+RF+ +
Sbjct: 365 RLFPVAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPFAV 419
           N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++     +KP K  + P  +
Sbjct: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFS-----FKPCKETQIPLKL 477

Query: 420 R 420
           R
Sbjct: 478 R 478


>BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 7 protein.
          Length = 503

 Score =  144 bits (350), Expect = 4e-34
 Identities = 116/421 (27%), Positives = 208/421 (49%), Gaps = 31/421 (7%)

Query: 11  RRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSPA 70
           ++P + + D   I+ VL  +  S  +          + ++I   +D   WK +R  LSP 
Sbjct: 78  QQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAED-EEWKRIRSLLSPT 136

Query: 71  FSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGVD 127
           F+S +LK M   I +     V  +     +G    L+ + F A   Y+   I +  FGV 
Sbjct: 137 FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHV-FGA---YSMDVITSTSFGVS 192

Query: 128 VDQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFID 182
           +D  N    P +  T+K L      +  F L+   FP L   L+ +N   F     SF+ 
Sbjct: 193 IDSLNNPQDPFVENTKKLLR--FNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLT 250

Query: 183 -AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            +VK++ E R    +++  DF+ + ++ QN    +D  T   +  +D  L          
Sbjct: 251 KSVKQIKEGRLKETQKHRVDFLQLMIDSQNS---KDSETHKAL--SDLELMAQSIIFIFA 305

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT++V+ F + EL+++P V +K+  EID V  + K    ++ + + +YL+MVVNET+
Sbjct: 306 GYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN-KAPPTYDTVLQLEYLDMVVNETL 364

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R +P    L+R+C K+  +  N + I K  + ++P   LH D +++ + + F P+RF+ +
Sbjct: 365 RLFPVAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPFAV 419
           N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++     +KP K  + P  +
Sbjct: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFS-----FKPCKETQIPLKL 477

Query: 420 R 420
           R
Sbjct: 478 R 478


>AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant
           3A7 protein.
          Length = 535

 Score =  144 bits (350), Expect = 4e-34
 Identities = 116/421 (27%), Positives = 208/421 (49%), Gaps = 31/421 (7%)

Query: 11  RRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSPA 70
           ++P + + D   I+ VL  +  S  +          + ++I   +D   WK +R  LSP 
Sbjct: 78  QQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAED-EEWKRIRSLLSPT 136

Query: 71  FSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGVD 127
           F+S +LK M   I +     V  +     +G    L+ + F A   Y+   I +  FGV 
Sbjct: 137 FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHV-FGA---YSMDVITSTSFGVS 192

Query: 128 VDQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFID 182
           +D  N    P +  T+K L      +  F L+   FP L   L+ +N   F     SF+ 
Sbjct: 193 IDSLNNPQDPFVENTKKLLR--FNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLT 250

Query: 183 -AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            +VK++ E R    +++  DF+ + ++ QN    +D  T   +  +D  L          
Sbjct: 251 KSVKQIKEGRLKETQKHRVDFLQLMIDSQNS---KDSETHKAL--SDLELMAQSIIFIFA 305

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT++V+ F + EL+++P V +K+  EID V  + K    ++ + + +YL+MVVNET+
Sbjct: 306 GYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN-KAPPTYDTVLQLEYLDMVVNETL 364

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R +P    L+R+C K+  +  N + I K  + ++P   LH D +++ + + F P+RF+ +
Sbjct: 365 RLFPVAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPFAV 419
           N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++     +KP K  + P  +
Sbjct: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFS-----FKPCKETQIPLKL 477

Query: 420 R 420
           R
Sbjct: 478 R 478


>AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450
           polypeptide 7 protein.
          Length = 503

 Score =  144 bits (350), Expect = 4e-34
 Identities = 116/421 (27%), Positives = 208/421 (49%), Gaps = 31/421 (7%)

Query: 11  RRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSPA 70
           ++P + + D   I+ VL  +  S  +          + ++I   +D   WK +R  LSP 
Sbjct: 78  QQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAED-EEWKRIRSLLSPT 136

Query: 71  FSSLRLKTMFEGIERSARDFVEFIEN---SGNDQDLEEMPFNAIYKYTTGSIGAAVFGVD 127
           F+S +LK M   I +     V  +     +G    L+ + F A   Y+   I +  FGV 
Sbjct: 137 FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHV-FGA---YSMDVITSTSFGVS 192

Query: 128 VDQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFID 182
           +D  N    P +  T+K L      +  F L+   FP L   L+ +N   F     SF+ 
Sbjct: 193 IDSLNNPQDPFVENTKKLLR--FNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLT 250

Query: 183 -AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            +VK++ E R    +++  DF+ + ++ QN    +D  T   +  +D  L          
Sbjct: 251 KSVKQIKEGRLKETQKHRVDFLQLMIDSQNS---KDSETHKAL--SDLELMAQSIIFIFA 305

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT++V+ F + EL+++P V +K+  EID V  + K    ++ + + +YL+MVVNET+
Sbjct: 306 GYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN-KAPPTYDTVLQLEYLDMVVNETL 364

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R +P    L+R+C K+  +  N + I K  + ++P   LH D +++ + + F P+RF+ +
Sbjct: 365 RLFPVAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPFAV 419
           N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++     +KP K  + P  +
Sbjct: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFS-----FKPCKETQIPLKL 477

Query: 420 R 420
           R
Sbjct: 478 R 478


>AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.
          Length = 353

 Score =  142 bits (345), Expect = 2e-33
 Identities = 92/299 (30%), Positives = 164/299 (54%), Gaps = 18/299 (6%)

Query: 114 YTTGSIGAAVFGVDVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGT-FPRLIKWLDMM 171
           Y+   I +  FGV++D  N    P +  T+K L      +  FFL+ T FP LI  L+++
Sbjct: 29  YSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVL 86

Query: 172 N---FDNYETSFI-DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPT 225
           N   F    T+F+  +VK++ E+R    +++  DF+ + ++ QN +      T      +
Sbjct: 87  NICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE-----TESHKALS 141

Query: 226 DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDM 285
           D  L            +TT++V+ F + EL+++P V +KL  EID V  + K    ++ +
Sbjct: 142 DLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTV 200

Query: 286 DKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFY 345
            + +YL+MVVNET+R +P    L+R+C K+  +  N + I K  + ++P  ALHRD +++
Sbjct: 201 LQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYW 258

Query: 346 PKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
            + + F P+RF+ +N + I+ + + PFG G R CIG +FA + ++  L  +L+ ++  P
Sbjct: 259 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 317


>BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family 4,
           subfamily V, polypeptide 2 protein.
          Length = 525

 Score =  124 bits (300), Expect = 5e-28
 Identities = 61/159 (38%), Positives = 96/159 (60%), Gaps = 2/159 (1%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA  ++++L  L SNP V KK+  E+D+VF    +    ED+ K +YLE V+ ET+R 
Sbjct: 332 DTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRL 391

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           +P + L  R  +++  +     R+ K T AV+   ALHRD R++P  + F P+RF PEN 
Sbjct: 392 FPSVPLFARSVSEDCEVAG--YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENA 449

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
              + ++++PF  G R CIG KFA ++ +  L+ +LR +
Sbjct: 450 QGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 488


>AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2
           protein.
          Length = 525

 Score =  124 bits (300), Expect = 5e-28
 Identities = 61/159 (38%), Positives = 96/159 (60%), Gaps = 2/159 (1%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA  ++++L  L SNP V KK+  E+D+VF    +    ED+ K +YLE V+ ET+R 
Sbjct: 332 DTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRL 391

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           +P + L  R  +++  +     R+ K T AV+   ALHRD R++P  + F P+RF PEN 
Sbjct: 392 FPSVPLFARSVSEDCEVAG--YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENA 449

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
              + ++++PF  G R CIG KFA ++ +  L+ +LR +
Sbjct: 450 QGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 488


>AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens
           cDNA FLJ44509 fis, clone UTERU3001585, weakly  similar
           to Cytochrome P450 4c3 (EC 1.14.-.-). ).
          Length = 503

 Score =  124 bits (300), Expect = 5e-28
 Identities = 61/159 (38%), Positives = 96/159 (60%), Gaps = 2/159 (1%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA  ++++L  L SNP V KK+  E+D+VF    +    ED+ K +YLE V+ ET+R 
Sbjct: 310 DTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRL 369

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           +P + L  R  +++  +     R+ K T AV+   ALHRD R++P  + F P+RF PEN 
Sbjct: 370 FPSVPLFARSVSEDCEVAG--YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENA 427

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
              + ++++PF  G R CIG KFA ++ +  L+ +LR +
Sbjct: 428 QGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 466


>AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens
           cDNA FLJ16007 fis, clone KIDNE2006580, weakly  similar
           to CYTOCHROME P450 4C1 (EC 1.14.14.1). ).
          Length = 525

 Score =  124 bits (300), Expect = 5e-28
 Identities = 61/159 (38%), Positives = 96/159 (60%), Gaps = 2/159 (1%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA  ++++L  L SNP V KK+  E+D+VF    +    ED+ K +YLE V+ ET+R 
Sbjct: 332 DTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRL 391

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           +P + L  R  +++  +     R+ K T AV+   ALHRD R++P  + F P+RF PEN 
Sbjct: 392 FPSVPLFARSVSEDCEVAG--YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENA 449

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
              + ++++PF  G R CIG KFA ++ +  L+ +LR +
Sbjct: 450 QGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 488


>AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfamily
           IIIA polypeptide 43 protein.
          Length = 420

 Score =  124 bits (298), Expect = 8e-28
 Identities = 96/355 (27%), Positives = 174/355 (49%), Gaps = 22/355 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G++P +++ D   I+ VL  +  S  +  + L     L  ++ F +D   WK +R  LSP
Sbjct: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAED-EEWKRIRTLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFI-ENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGVDV 128
           AF+S++ K M   I +     V  + + + N + +    F   Y  T   I   +FGV++
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAY--TMDVITGTLFGVNL 193

Query: 129 DQ-NTLDTPALNITRKALEPTLKSIMTFFLA-GTFPRLIKWLDMMN---FDNYETSFI-D 182
           D  N    P L   +K L+  L  +  F L    FP L    + +N   F    T F+ +
Sbjct: 194 DSLNNPQDPFLKNMKKLLK--LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251

Query: 183 AVKKVLENRRAGEKQY--DFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
           +++++ E+R   ++++  DF    ++ QN +  +          +D  L           
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKS-----HKALSDLELVAQSIIIIFAA 306

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R
Sbjct: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLR 365

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQR 355
            +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+R
Sbjct: 366 LFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>BC041157-1|AAH41157.1|  534|Homo sapiens thromboxane A synthase 1
           (platelet, cytochrome P450, family 5, subfamily A)
           protein.
          Length = 534

 Score =  123 bits (297), Expect = 1e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVAFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>BC014117-1|AAH14117.1|  466|Homo sapiens TBXAS1 protein protein.
          Length = 466

 Score =  123 bits (297), Expect = 1e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 13  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 71

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 72  LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVAFGT 130

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 131 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 188

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 189 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 248

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 249 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 306

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 307 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 364

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 365 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 424

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 425 TLLHVLHKFRFQACPETQVPLQLE 448


>AK223466-1|BAD97186.1|  534|Homo sapiens thromboxane A synthase 1
           (platelet, cytochrome P450, family 5, subfamily A) iso
           protein.
          Length = 534

 Score =  123 bits (297), Expect = 1e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVAFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF233619-1|AAF99273.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  123 bits (297), Expect = 1e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACELLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF233621-1|AAF99275.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  123 bits (296), Expect = 1e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYVLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF233620-1|AAF99274.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  123 bits (296), Expect = 1e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPSKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>M80647-1|AAA60618.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  122 bits (295), Expect = 2e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.
          Length = 393

 Score =  122 bits (295), Expect = 2e-27
 Identities = 73/264 (27%), Positives = 140/264 (53%), Gaps = 16/264 (6%)

Query: 161 FPRLIKWLDMMN---FDNYETSFI-DAVKKVLENRRAGEKQY--DFIDVCLELQNHEVLR 214
           FP L    + +N   F    T F+ ++++++ E+R   ++++  DF    ++ QN +  +
Sbjct: 116 FPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETK 175

Query: 215 DLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQ 274
                     +D  L            DTT+  + F + EL+++P V +KL  EID V  
Sbjct: 176 S-----HKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP 230

Query: 275 DGKKTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVP 334
           + K  + ++ + + +YL+MVVNET+R +P +  + R+C K+  +  N + I K    +VP
Sbjct: 231 N-KAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVP 287

Query: 335 VLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLA 394
           + ALH D +++ + + F P+RF+ +N + I+ + ++PFG G R CIG +FA   ++  + 
Sbjct: 288 IYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVI 347

Query: 395 WLLRKYTLVP--QDYKPVKFERSP 416
             L+ ++  P  +   P+K +  P
Sbjct: 348 RALQNFSFKPCKETQIPLKLDNLP 371


>AF233625-1|AAF99279.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  122 bits (295), Expect = 2e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHQPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF233622-1|AAF99276.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  122 bits (295), Expect = 2e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAEDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF233618-1|AAF99272.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  122 bits (295), Expect = 2e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF233617-1|AAF99271.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  122 bits (295), Expect = 2e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF233616-1|AAF99270.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  122 bits (295), Expect = 2e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF233615-1|AAF99269.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  122 bits (295), Expect = 2e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>D34625-1|BAA07011.1|  533|Homo sapiens thromboxane synthase
           protein.
          Length = 533

 Score =  122 bits (294), Expect = 2e-27
 Identities = 113/444 (25%), Positives = 203/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 80  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 138

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 139 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVAFGT 197

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 198 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 255

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 256 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 315

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 316 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 373

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 374 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 431

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G     L+++ 
Sbjct: 432 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVHLGLLEVKL 491

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 492 TLLHVLHKFRFQACPETQVPLQLE 515


>AF233624-1|AAF99278.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  122 bits (293), Expect = 3e-27
 Identities = 113/444 (25%), Positives = 204/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P  + F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPENFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF233623-1|AAF99277.1|  534|Homo sapiens thromboxane synthase
           protein.
          Length = 534

 Score =  121 bits (292), Expect = 4e-27
 Identities = 113/444 (25%), Positives = 203/444 (45%), Gaps = 45/444 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRA 391
            + V ALH D   +P    F+P+RF  E   +   F++LPFG G R C+G +   L+++ 
Sbjct: 433 EMAVGALHHDPEHWPSPKTFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 392 GLAWLLRKYTL--VPQDYKPVKFE 413
            L  +L K+     P+   P++ E
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLE 516


>AF133298-1|AAD49566.1|  520|Homo sapiens cytochrome P450 protein.
          Length = 520

 Score =  116 bits (278), Expect = 2e-25
 Identities = 65/219 (29%), Positives = 115/219 (52%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L       L +   G E+  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLL-------LSEDKNGKEL--SDEDIRAEADTFMFGGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+ +  +L M + E++R +PPI    R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFAR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP + + I K  +  + + A+H +   +P  + +DP RF PEN  + +  +F+
Sbjct: 401 GCTQDVVLPDSRV-IPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG KFA  +++  LA  L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREP 498


>U02388-1|AAC50052.2|  520|Homo sapiens cytochrome P450 4F2 protein.
          Length = 520

 Score =  113 bits (271), Expect = 2e-24
 Identities = 63/219 (28%), Positives = 114/219 (52%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+V+ + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASVLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+    +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRVHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
             T++  LP   + I K  I ++ V   H +   +P  + +DP RF PEN  E +  +F+
Sbjct: 401 HVTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEP 498


>AY792513-1|AAV40834.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 3 protein.
          Length = 520

 Score =  112 bits (269), Expect = 3e-24
 Identities = 61/219 (27%), Positives = 113/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+ +  +L M + E++R +PP+  + R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K  I ++ V   H +   +P  + +DP RF P+N  E +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  L   L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEP 498


>AF054821-1|AAC08589.1|  520|Homo sapiens cytochrome P-450 protein.
          Length = 520

 Score =  112 bits (269), Expect = 3e-24
 Identities = 61/219 (27%), Positives = 113/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+ +  +L M + E++R +PP+  + R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K  I ++ V   H +   +P  + +DP RF P+N  E +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  L   L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEP 498


>BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family
           46, subfamily A, polypeptide 1 protein.
          Length = 500

 Score =  111 bits (268), Expect = 3e-24
 Identities = 94/352 (26%), Positives = 162/352 (46%), Gaps = 26/352 (7%)

Query: 59  RWKILRQKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGS 118
           RW   R+ +  AFS   L ++ E     A   VE +E   + Q    M    +  YT   
Sbjct: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM--QDMLTYTAMD 190

Query: 119 IGA-AVFGVDVDQNT-LDTPALNITRKALEPTLKSIMTF--FLAGTFPRLIKWLDMMNFD 174
           I A A FG++         P     +  LE    S  T   FL G   +L +  + + F 
Sbjct: 191 ILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRF- 249

Query: 175 NYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXX 234
                     +  ++ RR   K+ + +         ++L  ++   E    DE L     
Sbjct: 250 -----LRQVGRDWVQRRREALKRGEEVPA-------DILTQILKAEEGAQDDEGLLDNFV 297

Query: 235 XXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMV 294
                  +T+AN + FT++ELS  P ++ +L AE+DEV    K+ L+FED+ + +YL  V
Sbjct: 298 TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI-GSKRYLDFEDLGRLQYLSQV 356

Query: 295 VNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQ 354
           + E++R YPP     R+  +ET +  + +R+  +T  +     + R + ++     F+P 
Sbjct: 357 LKESLRLYPPAWGTFRLLEEETLI--DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPD 414

Query: 355 RFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRK--YTLVP 404
           RF P       +F++ PF  G+R CIG +FA+++++  +A LL++  + LVP
Sbjct: 415 RFGPGAPKP--RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464


>AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxylase
           protein.
          Length = 500

 Score =  111 bits (268), Expect = 3e-24
 Identities = 94/352 (26%), Positives = 162/352 (46%), Gaps = 26/352 (7%)

Query: 59  RWKILRQKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGS 118
           RW   R+ +  AFS   L ++ E     A   VE +E   + Q    M    +  YT   
Sbjct: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM--QDMLTYTAMD 190

Query: 119 IGA-AVFGVDVDQNT-LDTPALNITRKALEPTLKSIMTF--FLAGTFPRLIKWLDMMNFD 174
           I A A FG++         P     +  LE    S  T   FL G   +L +  + + F 
Sbjct: 191 ILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRF- 249

Query: 175 NYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXX 234
                     +  ++ RR   K+ + +         ++L  ++   E    DE L     
Sbjct: 250 -----LRQVGRDWVQRRREALKRGEEVPA-------DILTQILKAEEGAQDDEGLLDNFV 297

Query: 235 XXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMV 294
                  +T+AN + FT++ELS  P ++ +L AE+DEV    K+ L+FED+ + +YL  V
Sbjct: 298 TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI-GSKRYLDFEDLGRLQYLSQV 356

Query: 295 VNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQ 354
           + E++R YPP     R+  +ET +  + +R+  +T  +     + R + ++     F+P 
Sbjct: 357 LKESLRLYPPAWGTFRLLEEETLI--DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPD 414

Query: 355 RFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRK--YTLVP 404
           RF P       +F++ PF  G+R CIG +FA+++++  +A LL++  + LVP
Sbjct: 415 RFGPGAPKP--RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464


>D12620-1|BAA02144.1|  520|Homo sapiens cytochrome P-450LTBV
           protein.
          Length = 520

 Score =  111 bits (266), Expect = 6e-24
 Identities = 61/219 (27%), Positives = 112/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+ +  +L M + E++R +PP+  + R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K  I ++ V   H +   +P  + +DP RF P+N  E +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  L   L  + ++P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVLPDHTEP 498


>AF236085-1|AAG15889.1|  524|Homo sapiens CYP4F11 protein.
          Length = 524

 Score =  111 bits (266), Expect = 6e-24
 Identities = 60/219 (27%), Positives = 114/219 (52%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G E+  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKEL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGKKT-LNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D +   + ++D+ +  +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K  + ++ ++ +H +   +P  + +DP RF  EN  E +  +F+
Sbjct: 401 CCTQDFVLPDGRV-IPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L  + ++P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHIEP 498


>AB002461-1|BAA25991.1|  520|Homo sapiens leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score =  111 bits (266), Expect = 6e-24
 Identities = 61/219 (27%), Positives = 112/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+ +  +L M + E++R +PP+  + R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K  I ++ V   H +   +P  + +DP RF P+N  E +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  L   L  + ++P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVLPDHTEP 498


>AB002454-1|BAA25990.1|  520|Homo sapiens leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score =  111 bits (266), Expect = 6e-24
 Identities = 61/219 (27%), Positives = 112/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+ +  +L M + E++R +PP+  + R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K  I ++ V   H +   +P  + +DP RF P+N  E +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  L   L  + ++P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVLPDHTEP 498


>BC067440-1|AAH67440.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 2 protein.
          Length = 520

 Score =  110 bits (265), Expect = 8e-24
 Identities = 62/219 (28%), Positives = 113/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+    +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
             T++  LP   + I K  I ++ V   H +   +P  + +DP RF PEN  E +  +F+
Sbjct: 401 HVTQDIVLPDGRV-IPKGIICLISVFGTHHNPAMWPDPEVYDPFRFDPENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEP 498


>BC016853-1|AAH16853.1|  524|Homo sapiens CYP4F11 protein protein.
          Length = 524

 Score =  110 bits (265), Expect = 8e-24
 Identities = 60/219 (27%), Positives = 114/219 (52%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G E+  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKEL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGKKT-LNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D +   + ++D+ +  +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K  + ++ ++ +H +   +P  + +DP RF  EN  E +  +F+
Sbjct: 401 CCTQDFVLPDGRV-IPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L  + ++P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEP 498


>AB015306-1|BAA75823.1|  520|Homo sapiens Leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score =  110 bits (265), Expect = 8e-24
 Identities = 62/219 (28%), Positives = 113/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+    +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
             T++  LP   + I K  I ++ V   H +   +P  + +DP RF PEN  E +  +F+
Sbjct: 401 HVTQDIVLPDGRV-IPKGIICLISVFGTHHNPAMWPDPEVYDPFRFDPENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEP 498


>D26480-1|BAA05490.1|  520|Homo sapiens leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score =  110 bits (264), Expect = 1e-23
 Identities = 62/219 (28%), Positives = 113/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+    +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
             T++  LP   + I K  I ++ V   H +   +P  + +DP RF PEN  E +  +F+
Sbjct: 401 HVTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEP 498


>BC067439-1|AAH67439.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 2 protein.
          Length = 520

 Score =  110 bits (264), Expect = 1e-23
 Identities = 62/219 (28%), Positives = 113/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+    +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
             T++  LP   + I K  I ++ V   H +   +P  + +DP RF PEN  E +  +F+
Sbjct: 401 HVTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEP 498


>BC067437-1|AAH67437.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 2 protein.
          Length = 520

 Score =  110 bits (264), Expect = 1e-23
 Identities = 62/219 (28%), Positives = 113/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+    +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
             T++  LP   + I K  I ++ V   H +   +P  + +DP RF PEN  E +  +F+
Sbjct: 401 HVTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEP 498


>AF467894-1|AAL67578.1|  520|Homo sapiens cytochrome P450, subfamily
           IVF, polypeptide 2 protein.
          Length = 520

 Score =  110 bits (264), Expect = 1e-23
 Identities = 62/219 (28%), Positives = 113/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+    +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
             T++  LP   + I K  I ++ V   H +   +P  + +DP RF PEN  E +  +F+
Sbjct: 401 HVTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEP 498


>AC005336-1|AAC27730.1|  520|Homo sapiens CYP4F2 protein.
          Length = 520

 Score =  110 bits (264), Expect = 1e-23
 Identities = 62/219 (28%), Positives = 113/219 (51%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L  ++ +       G ++  +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLLLSKDED-------GKKL--SDEDIRAEADTFMFEGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D + K + ++D+    +L M + E++R +PP+ ++ R
Sbjct: 341 LYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
             T++  LP   + I K  I ++ V   H +   +P  + +DP RF PEN  E +  +F+
Sbjct: 401 HVTQDIVLPDGRV-IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA  L ++ ++P   +P
Sbjct: 460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEP 498


>BC035350-1|AAH35350.1|  524|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 12 protein.
          Length = 524

 Score =  109 bits (261), Expect = 2e-23
 Identities = 63/219 (28%), Positives = 109/219 (49%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L L   E  + L        +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLL-LSKDEDGKAL--------SDEDIRAEADTFMFGGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQD-GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D   K + ++D+ +  +L M V E++R +PP   + R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K    ++ ++ +H +   +P  + +DP RF PEN    +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA +L  +  +P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEP 498


>AY358977-1|AAQ89336.1|  524|Homo sapiens CYP4F12 protein.
          Length = 524

 Score =  109 bits (261), Expect = 2e-23
 Identities = 63/219 (28%), Positives = 109/219 (49%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L L   E  + L        +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLL-LSKDEDGKAL--------SDEDIRAEADTFMFGGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQD-GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D   K + ++D+ +  +L M V E++R +PP   + R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K    ++ ++ +H +   +P  + +DP RF PEN    +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA +L  +  +P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEP 498


>AY008841-1|AAG33247.1|  524|Homo sapiens cytochrome P450 isoform
           4F12 protein.
          Length = 524

 Score =  109 bits (261), Expect = 2e-23
 Identities = 63/219 (28%), Positives = 109/219 (49%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L L   E  + L        +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLL-LSKDEDGKAL--------SDEDIRAEADTFMFGGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQD-GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D   K + ++D+ +  +L M V E++R +PP   + R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K    ++ ++ +H +   +P  + +DP RF PEN    +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA +L  +  +P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEP 498


>AC004523-1|AAC11543.1|  458|Homo sapiens F22329_1 protein.
          Length = 458

 Score =  109 bits (261), Expect = 2e-23
 Identities = 63/219 (28%), Positives = 109/219 (49%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L L   E  + L        +DE +            DTTA+ + + 
Sbjct: 224 KAKSKTLDFIDVLL-LSKDEDGKAL--------SDEDIRAEADTFMFGGHDTTASGLSWV 274

Query: 252 LLELSSNPSVLKKLHAEIDEVFQD-GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D   K + ++D+ +  +L M V E++R +PP   + R
Sbjct: 275 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 334

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K    ++ ++ +H +   +P  + +DP RF PEN    +  +F+
Sbjct: 335 CCTQDIVLPDGRV-IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFI 393

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA +L  +  +P   +P
Sbjct: 394 PFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEP 432


>AB035131-1|BAB18270.1|  524|Homo sapiens cytochrome P450 protein.
          Length = 524

 Score =  109 bits (261), Expect = 2e-23
 Identities = 63/219 (28%), Positives = 109/219 (49%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L L   E  + L        +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLL-LSKDEDGKAL--------SDEDIRAEADTFMFGGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQD-GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D   K + ++D+ +  +L M V E++R +PP   + R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K    ++ ++ +H +   +P  + +DP RF PEN    +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA +L  +  +P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEP 498


>AB035130-1|BAB18269.1|  524|Homo sapiens cytochrome P450 protein.
          Length = 524

 Score =  109 bits (261), Expect = 2e-23
 Identities = 63/219 (28%), Positives = 109/219 (49%), Gaps = 11/219 (5%)

Query: 192 RAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFT 251
           +A  K  DFIDV L L   E  + L        +DE +            DTTA+ + + 
Sbjct: 290 KAKSKTLDFIDVLL-LSKDEDGKAL--------SDEDIRAEADTFMFGGHDTTASGLSWV 340

Query: 252 LLELSSNPSVLKKLHAEIDEVFQD-GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQR 310
           L  L+ +P   ++   E+ E+ +D   K + ++D+ +  +L M V E++R +PP   + R
Sbjct: 341 LYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR 400

Query: 311 ICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFL 370
            CT++  LP   + I K    ++ ++ +H +   +P  + +DP RF PEN    +  +F+
Sbjct: 401 CCTQDIVLPDGRV-IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFI 459

Query: 371 PFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
           PF  G R CIG  FA  +++  LA +L  +  +P   +P
Sbjct: 460 PFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEP 498


>BC093896-1|AAH93896.1|  531|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 2 homolog protein.
          Length = 531

 Score =  107 bits (257), Expect = 8e-23
 Identities = 62/208 (29%), Positives = 107/208 (51%), Gaps = 11/208 (5%)

Query: 196 KQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLEL 255
           K  DFIDV L  ++ +       G E+  +DE +            DTT++ + + L  L
Sbjct: 301 KTLDFIDVLLLARDED-------GKEL--SDEDIRAEADTFMFEGHDTTSSGISWMLFNL 351

Query: 256 SSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTK 314
           +  P   +K   EI EV +  + + L ++D+ +  +  M + E++R+YPP+ L+ R CT+
Sbjct: 352 AKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTE 411

Query: 315 ETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGE 374
           +  LP   + I K  I +V +   H +   +P S  ++P RF P+N  + +  +++PF  
Sbjct: 412 DIKLPDGRI-IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSA 470

Query: 375 GNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           G R CIG  FA  +LR  +A  L ++ L
Sbjct: 471 GPRNCIGQSFAMAELRVVVALTLLRFRL 498


>BC093894-1|AAH93894.1|  531|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 2 homolog protein.
          Length = 531

 Score =  107 bits (257), Expect = 8e-23
 Identities = 62/208 (29%), Positives = 107/208 (51%), Gaps = 11/208 (5%)

Query: 196 KQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLEL 255
           K  DFIDV L  ++ +       G E+  +DE +            DTT++ + + L  L
Sbjct: 301 KTLDFIDVLLLARDED-------GKEL--SDEDIRAEADTFMFEGHDTTSSGISWMLFNL 351

Query: 256 SSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTK 314
           +  P   +K   EI EV +  + + L ++D+ +  +  M + E++R+YPP+ L+ R CT+
Sbjct: 352 AKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTE 411

Query: 315 ETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGE 374
           +  LP   + I K  I +V +   H +   +P S  ++P RF P+N  + +  +++PF  
Sbjct: 412 DIKLPDGRI-IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSA 470

Query: 375 GNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           G R CIG  FA  +LR  +A  L ++ L
Sbjct: 471 GPRNCIGQSFAMAELRVVVALTLLRFRL 498


>BC069351-1|AAH69351.1|  531|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 2 homolog protein.
          Length = 531

 Score =  107 bits (257), Expect = 8e-23
 Identities = 62/208 (29%), Positives = 107/208 (51%), Gaps = 11/208 (5%)

Query: 196 KQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLEL 255
           K  DFIDV L  ++ +       G E+  +DE +            DTT++ + + L  L
Sbjct: 301 KTLDFIDVLLLARDED-------GKEL--SDEDIRAEADTFMFEGHDTTSSGISWMLFNL 351

Query: 256 SSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTK 314
           +  P   +K   EI EV +  + + L ++D+ +  +  M + E++R+YPP+ L+ R CT+
Sbjct: 352 AKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTE 411

Query: 315 ETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGE 374
           +  LP   + I K  I +V +   H +   +P S  ++P RF P+N  + +  +++PF  
Sbjct: 412 DIKLPDGRI-IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSA 470

Query: 375 GNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           G R CIG  FA  +LR  +A  L ++ L
Sbjct: 471 GPRNCIGQSFAMAELRVVVALTLLRFRL 498


>AK096820-1|BAC04868.1|  531|Homo sapiens protein ( Homo sapiens
           cDNA FLJ39501 fis, clone PROST2016980, moderately
           similar to CYTOCHROME P450 4F2 (EC 1.14.13.30). ).
          Length = 531

 Score =  107 bits (257), Expect = 8e-23
 Identities = 62/208 (29%), Positives = 107/208 (51%), Gaps = 11/208 (5%)

Query: 196 KQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLEL 255
           K  DFIDV L  ++ +       G E+  +DE +            DTT++ + + L  L
Sbjct: 301 KTLDFIDVLLLARDED-------GKEL--SDEDIRAEADTFMFEGHDTTSSGISWMLFNL 351

Query: 256 SSNPSVLKKLHAEIDEVFQDGK-KTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTK 314
           +  P   +K   EI EV +  + + L ++D+ +  +  M + E++R+YPP+ L+ R CT+
Sbjct: 352 AKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTE 411

Query: 315 ETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGE 374
           +  LP   + I K  I +V +   H +   +P S  ++P RF P+N  + +  +++PF  
Sbjct: 412 DIKLPDGRI-IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSA 470

Query: 375 GNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           G R CIG  FA  +LR  +A  L ++ L
Sbjct: 471 GPRNCIGQSFAMAELRVVVALTLLRFRL 498


>L13286-1|AAA62379.1|  513|Homo sapiens 1,25-dihydroxyvitamin D3
           24-hydroxylase protein.
          Length = 513

 Score =  104 bits (249), Expect = 7e-22
 Identities = 61/174 (35%), Positives = 89/174 (51%), Gaps = 4/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TTAN + + L  LS NP V +KL  EI  V  + ++    ED+    YL+  + E+MR 
Sbjct: 328 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQRPRE-EDLRNMPYLKACLKESMRL 386

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
            P +    R   K T L      + K T+ ++    L   E  +  S  F P+R+  E  
Sbjct: 387 TPGVPFTTRTLDKATVL--GEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK- 443

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
            +IN F+ LPFG G R+CIG + A LQL   L W++RKY +   D +PV+   S
Sbjct: 444 EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHS 497


>S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D
           24-hydroxylase cytochrome P450 subunit protein.
          Length = 257

 Score =  103 bits (246), Expect = 2e-21
 Identities = 61/174 (35%), Positives = 88/174 (50%), Gaps = 4/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TTAN + + L  LS NP V +KL  EI  V  + +     ED+    YL+  + E+MR 
Sbjct: 72  ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVP-RAEDLRNMPYLKACLKESMRL 130

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
            P +    R   K T L      + K T+ ++    L   E  +  S  F P+R+  E  
Sbjct: 131 TPSVPFTTRTLDKATVL--GEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK- 187

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
            +IN F+ LPFG G R+CIG + A LQL   L W++RKY +   D +PV+   S
Sbjct: 188 EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHS 241


>AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylase
           splice variant protein.
          Length = 372

 Score =  103 bits (246), Expect = 2e-21
 Identities = 61/174 (35%), Positives = 88/174 (50%), Gaps = 4/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TTAN + + L  LS NP V +KL  EI  V  + +     ED+    YL+  + E+MR 
Sbjct: 187 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVP-RAEDLRNMPYLKACLKESMRL 245

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
            P +    R   K T L      + K T+ ++    L   E  +  S  F P+R+  E  
Sbjct: 246 TPSVPFTTRTLDKATVL--GEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK- 302

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
            +IN F+ LPFG G R+CIG + A LQL   L W++RKY +   D +PV+   S
Sbjct: 303 EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHS 356


>AL138805-3|CAB91829.1|  514|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 514

 Score =  103 bits (246), Expect = 2e-21
 Identities = 61/174 (35%), Positives = 88/174 (50%), Gaps = 4/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TTAN + + L  LS NP V +KL  EI  V  + +     ED+    YL+  + E+MR 
Sbjct: 329 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVP-RAEDLRNMPYLKACLKESMRL 387

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
            P +    R   K T L      + K T+ ++    L   E  +  S  F P+R+  E  
Sbjct: 388 TPSVPFTTRTLDKATVL--GEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK- 444

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
            +IN F+ LPFG G R+CIG + A LQL   L W++RKY +   D +PV+   S
Sbjct: 445 EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHS 498


>AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 372

 Score =  103 bits (246), Expect = 2e-21
 Identities = 61/174 (35%), Positives = 88/174 (50%), Gaps = 4/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TTAN + + L  LS NP V +KL  EI  V  + +     ED+    YL+  + E+MR 
Sbjct: 187 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVP-RAEDLRNMPYLKACLKESMRL 245

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
            P +    R   K T L      + K T+ ++    L   E  +  S  F P+R+  E  
Sbjct: 246 TPSVPFTTRTLDKATVL--GEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK- 302

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
            +IN F+ LPFG G R+CIG + A LQL   L W++RKY +   D +PV+   S
Sbjct: 303 EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHS 356


>BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family 2,
           subfamily U, polypeptide 1 protein.
          Length = 544

 Score = 94.3 bits (224), Expect = 8e-19
 Identities = 95/411 (23%), Positives = 169/411 (41%), Gaps = 17/411 (4%)

Query: 6   AFTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKILR 64
           +F +G    ++L D   ++  L    + F  R  + L    T    ++F    P W   R
Sbjct: 119 SFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVW---R 175

Query: 65  QKLSPAFSSLRLKTMFE-GIERSARDFVEFIENSGNDQDLEEM-PFNAIYKYTTGSIGAA 122
           Q+   + S+LR   + +  +E    +  ++++        +   PF+ I    +  I + 
Sbjct: 176 QQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSL 235

Query: 123 VFGVDVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGTFPRLIKWLDMMNFDNYETSFI 181
            FG   D  N+     L    + LE  L S +       +   + +         E    
Sbjct: 236 CFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDIT 295

Query: 182 DAVKKVLENRRAG---EKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +KK++++ +     E   DFID+ L     E   +  + ++    +E L         
Sbjct: 296 SFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFD----EEYLFYIIGDLFI 351

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              DTT N + + LL +S NP V +K+H EI+ V     +  +  D  +  Y E  + E 
Sbjct: 352 AGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVI-GANRAPSLTDKAQMPYTEATIMEV 410

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
            R    + L     T E N       I K T+ +  + ++HRD   + K + F P RF  
Sbjct: 411 QRLTVVVPLAIPHMTSE-NTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLD 469

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYK 408
           +    I K +F+PFG G RVC+G + A+++L      L++ +   +P+D K
Sbjct: 470 DQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSK 520


>AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.
          Length = 544

 Score = 94.3 bits (224), Expect = 8e-19
 Identities = 95/411 (23%), Positives = 169/411 (41%), Gaps = 17/411 (4%)

Query: 6   AFTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKILR 64
           +F +G    ++L D   ++  L    + F  R  + L    T    ++F    P W   R
Sbjct: 119 SFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVW---R 175

Query: 65  QKLSPAFSSLRLKTMFE-GIERSARDFVEFIENSGNDQDLEEM-PFNAIYKYTTGSIGAA 122
           Q+   + S+LR   + +  +E    +  ++++        +   PF+ I    +  I + 
Sbjct: 176 QQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSL 235

Query: 123 VFGVDVDQ-NTLDTPALNITRKALEPTLKSIMTFFLAGTFPRLIKWLDMMNFDNYETSFI 181
            FG   D  N+     L    + LE  L S +       +   + +         E    
Sbjct: 236 CFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDIT 295

Query: 182 DAVKKVLENRRAG---EKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXX 238
             +KK++++ +     E   DFID+ L     E   +  + ++    +E L         
Sbjct: 296 SFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFD----EEYLFYIIGDLFI 351

Query: 239 XXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNET 298
              DTT N + + LL +S NP V +K+H EI+ V     +  +  D  +  Y E  + E 
Sbjct: 352 AGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVI-GANRAPSLTDKAQMPYTEATIMEV 410

Query: 299 MRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAP 358
            R    + L     T E N       I K T+ +  + ++HRD   + K + F P RF  
Sbjct: 411 QRLTVVVPLAIPHMTSE-NTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLD 469

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYK 408
           +    I K +F+PFG G RVC+G + A+++L      L++ +   +P+D K
Sbjct: 470 DQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSK 520


>AK090886-1|BAC03539.1|  337|Homo sapiens protein ( Homo sapiens
           cDNA FLJ33567 fis, clone BRAMY2010272, highly similar to
           Homo sapiens cholesterol 24-hydroxylase mRNA. ).
          Length = 337

 Score = 93.9 bits (223), Expect = 1e-18
 Identities = 58/196 (29%), Positives = 103/196 (52%), Gaps = 17/196 (8%)

Query: 211 EVLRDLVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEID 270
           ++L  ++   E    DE L            +T+AN + FT++ELS  P ++ +L AE+D
Sbjct: 121 DILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVD 180

Query: 271 EVFQDGKKTLNFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTI 330
           EV    K+ L+FED+ + +YL  V+ E++R YPP     R+  +ET +   +  +     
Sbjct: 181 EVI-GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGFSTYV----- 234

Query: 331 AVVPVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLR 390
                  + R + ++     F+P RF P       +F++ PF  G+R CIG +FA+++++
Sbjct: 235 -------MGRMDTYFEDPLTFNPDRFGPGAPKP--RFTYFPFSLGHRSCIGQQFAQMEVK 285

Query: 391 AGLAWLLRK--YTLVP 404
             +A LL++  + LVP
Sbjct: 286 VVMAKLLQRLEFRLVP 301


>S67581-1|AAB29503.1|  591|Homo sapiens fatty acid omega-hydroxylase
           protein.
          Length = 591

 Score = 93.5 bits (222), Expect = 1e-18
 Identities = 50/174 (28%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  +L+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIAR 493


>S67580-1|AAB29502.1|  519|Homo sapiens fatty acid omega-hydroxylase
           protein.
          Length = 519

 Score = 93.5 bits (222), Expect = 1e-18
 Identities = 50/174 (28%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  +L+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIAR 493


>AY358631-1|AAQ88994.1|  505|Homo sapiens EPSW3060 protein.
          Length = 505

 Score = 93.5 bits (222), Expect = 1e-18
 Identities = 57/228 (25%), Positives = 110/228 (48%), Gaps = 11/228 (4%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           +++K  L+     ++++DF+D+ L  ++ E  +D         ++  L            
Sbjct: 266 ESLKDKLKQDTTQKRRWDFLDILLSAKS-ENTKDF--------SEADLQAEVKTFMFAGH 316

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT++ + + L  L+  P   ++   EI E+  DG  ++ +E + +  Y  M + E +R 
Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQMPYTTMCIKECLRL 375

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           Y P+  + R+  K    P      +  T+  + + ALH +  F+     F+P RF+ EN 
Sbjct: 376 YAPVVNISRLLDKPITFPDGRSLPAGITV-FINIWALHHNPYFWEDPQVFNPLRFSRENS 434

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
            +I+ ++F+PF  G R CIG  FA ++ +  +A  L ++ L P   +P
Sbjct: 435 EKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRP 482


>AY280372-1|AAQ21368.1|  519|Homo sapiens cytochrome P450 4A22
           protein.
          Length = 519

 Score = 93.5 bits (222), Expect = 1e-18
 Identities = 51/174 (29%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHGLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  QL+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMAR 493


>AY262056-1|AAO89257.1|  505|Homo sapiens cytochrome P450 protein.
          Length = 505

 Score = 93.5 bits (222), Expect = 1e-18
 Identities = 57/228 (25%), Positives = 110/228 (48%), Gaps = 11/228 (4%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           +++K  L+     ++++DF+D+ L  ++ E  +D         ++  L            
Sbjct: 266 ESLKDKLKQDTTQKRRWDFLDILLSAKS-ENTKDF--------SEADLQAEVKTFMFAGH 316

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT++ + + L  L+  P   ++   EI E+  DG  ++ +E + +  Y  M + E +R 
Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQMPYTTMCIKECLRL 375

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           Y P+  + R+  K    P      +  T+  + + ALH +  F+     F+P RF+ EN 
Sbjct: 376 YAPVVNISRLLDKPITFPDGRSLPAGITV-FINIWALHHNPYFWEDPQVFNPLRFSRENS 434

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
            +I+ ++F+PF  G R CIG  FA ++ +  +A  L ++ L P   +P
Sbjct: 435 EKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRP 482


>AL450996-2|CAH71036.1|  505|Homo sapiens cytochrome P450, family 4,
           subfamily Z, polypeptide 1 protein.
          Length = 505

 Score = 93.5 bits (222), Expect = 1e-18
 Identities = 57/228 (25%), Positives = 110/228 (48%), Gaps = 11/228 (4%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           +++K  L+     ++++DF+D+ L  ++ E  +D         ++  L            
Sbjct: 266 ESLKDKLKQDTTQKRRWDFLDILLSAKS-ENTKDF--------SEADLQAEVKTFMFAGH 316

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT++ + + L  L+  P   ++   EI E+  DG  ++ +E + +  Y  M + E +R 
Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQMPYTTMCIKECLRL 375

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           Y P+  + R+  K    P      +  T+  + + ALH +  F+     F+P RF+ EN 
Sbjct: 376 YAPVVNISRLLDKPITFPDGRSLPAGITV-FINIWALHHNPYFWEDPQVFNPLRFSRENS 434

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
            +I+ ++F+PF  G R CIG  FA ++ +  +A  L ++ L P   +P
Sbjct: 435 EKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRP 482


>AL135960-6|CAI19734.1|  505|Homo sapiens cytochrome P450, family 4,
           subfamily Z, polypeptide 1 protein.
          Length = 505

 Score = 93.5 bits (222), Expect = 1e-18
 Identities = 57/228 (25%), Positives = 110/228 (48%), Gaps = 11/228 (4%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           +++K  L+     ++++DF+D+ L  ++ E  +D         ++  L            
Sbjct: 266 ESLKDKLKQDTTQKRRWDFLDILLSAKS-ENTKDF--------SEADLQAEVKTFMFAGH 316

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT++ + + L  L+  P   ++   EI E+  DG  ++ +E + +  Y  M + E +R 
Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS-SITWEHLSQMPYTTMCIKECLRL 375

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           Y P+  + R+  K    P      +  T+  + + ALH +  F+     F+P RF+ EN 
Sbjct: 376 YAPVVNISRLLDKPITFPDGRSLPAGITV-FINIWALHHNPYFWEDPQVFNPLRFSRENS 434

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKP 409
            +I+ ++F+PF  G R CIG  FA ++ +  +A  L ++ L P   +P
Sbjct: 435 EKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRP 482


>AY280371-1|AAQ21367.1|  519|Homo sapiens cytochrome P450 4A22K
           protein.
          Length = 519

 Score = 93.1 bits (221), Expect = 2e-18
 Identities = 51/174 (29%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  QL+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRTPIPMAR 493


>AL135960-10|CAI19737.1|  519|Homo sapiens cytochrome P450, family
           4, subfamily A, polypeptide 22 protein.
          Length = 519

 Score = 93.1 bits (221), Expect = 2e-18
 Identities = 51/174 (29%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHGLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  QL+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMAR 493


>AF208532-1|AAF76722.1|  519|Homo sapiens fatty acid
           omega-hydroxylase CYP4A11 protein.
          Length = 519

 Score = 93.1 bits (221), Expect = 2e-18
 Identities = 51/174 (29%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHGLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  QL+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPIAR 493


>L04751-1|AAA58436.1|  519|Homo sapiens cytochrome P450 protein.
          Length = 519

 Score = 92.3 bits (219), Expect = 3e-18
 Identities = 50/174 (28%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  +L+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIAR 493


>D26481-1|BAA05491.1|  519|Homo sapiens fatty acids
           omega-hydroxylase protein.
          Length = 519

 Score = 92.3 bits (219), Expect = 3e-18
 Identities = 50/174 (28%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  +L+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIAR 493


>AY369778-1|AAQ56847.1|  519|Homo sapiens cytochrome P450, family 4,
           subfamily A, polypeptide 11 protein.
          Length = 519

 Score = 92.3 bits (219), Expect = 3e-18
 Identities = 50/174 (28%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  +L+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIAR 493


>AL731892-3|CAH72778.1|  519|Homo sapiens cytochrome P450, family 4,
           subfamily A, polypeptide 11 protein.
          Length = 519

 Score = 92.3 bits (219), Expect = 3e-18
 Identities = 50/174 (28%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  +L+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIAR 493


>BC028102-1|AAH28102.1|  509|Homo sapiens cytochrome P450, family 4,
           subfamily X, polypeptide 1 protein.
          Length = 509

 Score = 91.1 bits (216), Expect = 7e-18
 Identities = 85/372 (22%), Positives = 154/372 (41%), Gaps = 28/372 (7%)

Query: 56  DLPRWKILRQKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYT 115
           D P+W   R+ L+P F    LK   E +  S +  ++  E   + QD     +  I   +
Sbjct: 129 DGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMS 188

Query: 116 TGSIGAAVFGVDVDQNTLDT-----PALNITRKALEPTLKSIM-----TFFLAGTFPRLI 165
              I    F  + +  T  T      A+    K +   L S++      F L+    R  
Sbjct: 189 LDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 248

Query: 166 KWLDMMNFDNYETSFIDAVKKVLE-----NRRAGEKQYDFIDVCLELQNHEVLRDLVTGY 220
           K   ++N   Y  + I   KK L+     +     K  DF+D+ L  ++        +G 
Sbjct: 249 KLSRVLN--QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-------SGS 299

Query: 221 EIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL 280
                D  +            DT A  + + L  L+ NP   ++   E+  +  DG  ++
Sbjct: 300 SFSDID--VHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SI 356

Query: 281 NFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHR 340
            ++ + +  Y  M + ET R  P +  + R  +K    P +   +      V+ +  LH 
Sbjct: 357 TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DGCTLPAGITVVLSIWGLHH 415

Query: 341 DERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +   +     FDP RF+ EN ++ + +++LPF  G+R CIG +FA ++L+  +A +L  +
Sbjct: 416 NPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 401 TLVPQDYKPVKF 412
            + P   +P+ F
Sbjct: 476 RVTPDPTRPLTF 487


>AY358537-1|AAQ88901.1|  509|Homo sapiens EFSW1929 protein.
          Length = 509

 Score = 91.1 bits (216), Expect = 7e-18
 Identities = 85/372 (22%), Positives = 154/372 (41%), Gaps = 28/372 (7%)

Query: 56  DLPRWKILRQKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYT 115
           D P+W   R+ L+P F    LK   E +  S +  ++  E   + QD     +  I   +
Sbjct: 129 DGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMS 188

Query: 116 TGSIGAAVFGVDVDQNTLDT-----PALNITRKALEPTLKSIM-----TFFLAGTFPRLI 165
              I    F  + +  T  T      A+    K +   L S++      F L+    R  
Sbjct: 189 LDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 248

Query: 166 KWLDMMNFDNYETSFIDAVKKVLE-----NRRAGEKQYDFIDVCLELQNHEVLRDLVTGY 220
           K   ++N   Y  + I   KK L+     +     K  DF+D+ L  ++        +G 
Sbjct: 249 KLSRVLN--QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-------SGS 299

Query: 221 EIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL 280
                D  +            DT A  + + L  L+ NP   ++   E+  +  DG  ++
Sbjct: 300 SFSDID--VHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SI 356

Query: 281 NFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHR 340
            ++ + +  Y  M + ET R  P +  + R  +K    P +   +      V+ +  LH 
Sbjct: 357 TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DGCTLPAGITVVLSIWGLHH 415

Query: 341 DERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +   +     FDP RF+ EN ++ + +++LPF  G+R CIG +FA ++L+  +A +L  +
Sbjct: 416 NPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 401 TLVPQDYKPVKF 412
            + P   +P+ F
Sbjct: 476 RVTPDPTRPLTF 487


>AM040940-1|CAJ13826.1|  509|Homo sapiens cytochrome P450 protein.
          Length = 509

 Score = 91.1 bits (216), Expect = 7e-18
 Identities = 85/372 (22%), Positives = 154/372 (41%), Gaps = 28/372 (7%)

Query: 56  DLPRWKILRQKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYT 115
           D P+W   R+ L+P F    LK   E +  S +  ++  E   + QD     +  I   +
Sbjct: 129 DGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMS 188

Query: 116 TGSIGAAVFGVDVDQNTLDT-----PALNITRKALEPTLKSIM-----TFFLAGTFPRLI 165
              I    F  + +  T  T      A+    K +   L S++      F L+    R  
Sbjct: 189 LDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 248

Query: 166 KWLDMMNFDNYETSFIDAVKKVLE-----NRRAGEKQYDFIDVCLELQNHEVLRDLVTGY 220
           K   ++N   Y  + I   KK L+     +     K  DF+D+ L  ++        +G 
Sbjct: 249 KLSRVLN--QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-------SGS 299

Query: 221 EIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL 280
                D  +            DT A  + + L  L+ NP   ++   E+  +  DG  ++
Sbjct: 300 SFSDID--VHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SI 356

Query: 281 NFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHR 340
            ++ + +  Y  M + ET R  P +  + R  +K    P +   +      V+ +  LH 
Sbjct: 357 TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DGCTLPAGITVVLSIWGLHH 415

Query: 341 DERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +   +     FDP RF+ EN ++ + +++LPF  G+R CIG +FA ++L+  +A +L  +
Sbjct: 416 NPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 401 TLVPQDYKPVKF 412
            + P   +P+ F
Sbjct: 476 RVTPDPTRPLTF 487


>AL450996-1|CAH71035.1|  509|Homo sapiens cytochrome P450, family 4,
           subfamily X, polypeptide 1 protein.
          Length = 509

 Score = 91.1 bits (216), Expect = 7e-18
 Identities = 85/372 (22%), Positives = 154/372 (41%), Gaps = 28/372 (7%)

Query: 56  DLPRWKILRQKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYT 115
           D P+W   R+ L+P F    LK   E +  S +  ++  E   + QD     +  I   +
Sbjct: 129 DGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMS 188

Query: 116 TGSIGAAVFGVDVDQNTLDT-----PALNITRKALEPTLKSIM-----TFFLAGTFPRLI 165
              I    F  + +  T  T      A+    K +   L S++      F L+    R  
Sbjct: 189 LDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 248

Query: 166 KWLDMMNFDNYETSFIDAVKKVLE-----NRRAGEKQYDFIDVCLELQNHEVLRDLVTGY 220
           K   ++N   Y  + I   KK L+     +     K  DF+D+ L  ++        +G 
Sbjct: 249 KLSRVLN--QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-------SGS 299

Query: 221 EIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL 280
                D  +            DT A  + + L  L+ NP   ++   E+  +  DG  ++
Sbjct: 300 SFSDID--VHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SI 356

Query: 281 NFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHR 340
            ++ + +  Y  M + ET R  P +  + R  +K    P +   +      V+ +  LH 
Sbjct: 357 TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DGCTLPAGITVVLSIWGLHH 415

Query: 341 DERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +   +     FDP RF+ EN ++ + +++LPF  G+R CIG +FA ++L+  +A +L  +
Sbjct: 416 NPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 401 TLVPQDYKPVKF 412
            + P   +P+ F
Sbjct: 476 RVTPDPTRPLTF 487


>AK098065-1|BAC05226.1|  509|Homo sapiens protein ( Homo sapiens
           cDNA FLJ40746 fis, clone TRACH2000359, weakly similar to
           CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
          Length = 509

 Score = 91.1 bits (216), Expect = 7e-18
 Identities = 85/372 (22%), Positives = 154/372 (41%), Gaps = 28/372 (7%)

Query: 56  DLPRWKILRQKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYT 115
           D P+W   R+ L+P F    LK   E +  S +  ++  E   + QD     +  I   +
Sbjct: 129 DGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMS 188

Query: 116 TGSIGAAVFGVDVDQNTLDT-----PALNITRKALEPTLKSIM-----TFFLAGTFPRLI 165
              I    F  + +  T  T      A+    K +   L S++      F L+    R  
Sbjct: 189 LDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 248

Query: 166 KWLDMMNFDNYETSFIDAVKKVLE-----NRRAGEKQYDFIDVCLELQNHEVLRDLVTGY 220
           K   ++N   Y  + I   KK L+     +     K  DF+D+ L  ++        +G 
Sbjct: 249 KLSRVLN--QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-------SGS 299

Query: 221 EIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL 280
                D  +            DT A  + + L  L+ NP   ++   E+  +  DG  ++
Sbjct: 300 SFSDID--VHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SI 356

Query: 281 NFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHR 340
            ++ + +  Y  M + ET R  P +  + R  +K    P +   +      V+ +  LH 
Sbjct: 357 TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DGCTLPAGITVVLSIWGLHH 415

Query: 341 DERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +   +     FDP RF+ EN ++ + +++LPF  G+R CIG +FA ++L+  +A +L  +
Sbjct: 416 NPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 475

Query: 401 TLVPQDYKPVKF 412
            + P   +P+ F
Sbjct: 476 RVTPDPTRPLTF 487


>AK091806-1|BAC03751.1|  444|Homo sapiens protein ( Homo sapiens
           cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to
           CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
          Length = 444

 Score = 91.1 bits (216), Expect = 7e-18
 Identities = 85/372 (22%), Positives = 154/372 (41%), Gaps = 28/372 (7%)

Query: 56  DLPRWKILRQKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYT 115
           D P+W   R+ L+P F    LK   E +  S +  ++  E   + QD     +  I   +
Sbjct: 64  DGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMS 123

Query: 116 TGSIGAAVFGVDVDQNTLDT-----PALNITRKALEPTLKSIM-----TFFLAGTFPRLI 165
              I    F  + +  T  T      A+    K +   L S++      F L+    R  
Sbjct: 124 LDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 183

Query: 166 KWLDMMNFDNYETSFIDAVKKVLE-----NRRAGEKQYDFIDVCLELQNHEVLRDLVTGY 220
           K   ++N   Y  + I   KK L+     +     K  DF+D+ L  ++        +G 
Sbjct: 184 KLSRVLN--QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-------SGS 234

Query: 221 EIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL 280
                D  +            DT A  + + L  L+ NP   ++   E+  +  DG  ++
Sbjct: 235 SFSDID--VHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SI 291

Query: 281 NFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHR 340
            ++ + +  Y  M + ET R  P +  + R  +K    P +   +      V+ +  LH 
Sbjct: 292 TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DGCTLPAGITVVLSIWGLHH 350

Query: 341 DERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +   +     FDP RF+ EN ++ + +++LPF  G+R CIG +FA ++L+  +A +L  +
Sbjct: 351 NPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 410

Query: 401 TLVPQDYKPVKF 412
            + P   +P+ F
Sbjct: 411 RVTPDPTRPLTF 422


>M80646-1|AAA60617.1|  460|Homo sapiens thromboxane synthase
           protein.
          Length = 460

 Score = 90.6 bits (215), Expect = 9e-18
 Identities = 95/385 (24%), Positives = 174/385 (45%), Gaps = 43/385 (11%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  +L  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVPFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLAGTFPRLI----KWLDMMNFDNYETSF 180
            VD     + P +   ++  E  + + I+   L+  FP ++    + L   N D     F
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS--FPSIMVPLARILPNKNRDELNGFF 256

Query: 181 IDAVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVPT- 225
              ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P+ 
Sbjct: 257 NKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSR 316

Query: 226 -------------DELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
                        DE++              T N + F    L++NP   +KL  E+D V
Sbjct: 317 QHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT-NTLSFATYLLATNPDCQEKLLREVD-V 374

Query: 273 FQDGKKTLNFEDMDK-FKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIA 331
           F++      F  +++   YL+MV+ ET+R YPP     R   ++  +     RI    + 
Sbjct: 375 FKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--RIPAGAVL 432

Query: 332 VVPVLALHRDERFYPKSDAFDPQRF 356
            + V ALH D   +P  + F+P+R+
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERY 457


>AK131355-1|BAD18508.1|  508|Homo sapiens protein ( Homo sapiens
           cDNA FLJ16384 fis, clone TLIVE2007607, weakly  similar
           to CYTOCHROME P450 4A4 (EC 1.14.14.1). ).
          Length = 508

 Score = 90.6 bits (215), Expect = 9e-18
 Identities = 84/372 (22%), Positives = 154/372 (41%), Gaps = 28/372 (7%)

Query: 56  DLPRWKILRQKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYT 115
           D P+W   R+ L+P F    LK   E +  S +  ++  E   + QD     +  I   +
Sbjct: 128 DGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMS 187

Query: 116 TGSIGAAVFGVDVDQNTLDT-----PALNITRKALEPTLKSIM-----TFFLAGTFPRLI 165
              +    F  + +  T  T      A+    K +   L S++      F L+    R  
Sbjct: 188 LDIVMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 247

Query: 166 KWLDMMNFDNYETSFIDAVKKVLE-----NRRAGEKQYDFIDVCLELQNHEVLRDLVTGY 220
           K   ++N   Y  + I   KK L+     +     K  DF+D+ L  ++        +G 
Sbjct: 248 KLSRVLN--QYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDE-------SGS 298

Query: 221 EIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL 280
                D  +            DT A  + + L  L+ NP   ++   E+  +  DG  ++
Sbjct: 299 SFSDID--VHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGS-SI 355

Query: 281 NFEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHR 340
            ++ + +  Y  M + ET R  P +  + R  +K    P +   +      V+ +  LH 
Sbjct: 356 TWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-DGCTLPAGITVVLSIWGLHH 414

Query: 341 DERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +   +     FDP RF+ EN ++ + +++LPF  G+R CIG +FA ++L+  +A +L  +
Sbjct: 415 NPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHF 474

Query: 401 TLVPQDYKPVKF 412
            + P   +P+ F
Sbjct: 475 RVTPDPTRPLTF 486


>AF525488-1|AAO16078.1|  519|Homo sapiens cytochrome P450, subfamily
           IVA, polypeptide 11 protein.
          Length = 519

 Score = 90.6 bits (215), Expect = 9e-18
 Identities = 49/174 (28%), Positives = 90/174 (51%), Gaps = 5/174 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           +PP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 FPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  +L+   A  L ++ L+P   + P+   R
Sbjct: 442 Q--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIAR 493


>AJ563378-3|CAD91347.1|  173|Homo sapiens hypothetical protein
           protein.
          Length = 173

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 41/123 (33%), Positives = 76/123 (61%), Gaps = 3/123 (2%)

Query: 282 FEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRD 341
           ++ + + +YL+MVVNET+R +P    L+R C K+  +  N + I K ++ V+P  ALH D
Sbjct: 18  YDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--NGVFIPKGSMVVIPTYALHHD 75

Query: 342 ERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYT 401
            +++ + + F P+RF+ +  + I+ + + PFG G R CIG +FA + ++  L  +L+ ++
Sbjct: 76  PKYWTEPEEFRPERFSKKK-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 134

Query: 402 LVP 404
             P
Sbjct: 135 FKP 137


>AJ563378-2|CAD91647.1|  160|Homo sapiens cytochrome P450 protein.
          Length = 160

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 41/123 (33%), Positives = 76/123 (61%), Gaps = 3/123 (2%)

Query: 282 FEDMDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRD 341
           ++ + + +YL+MVVNET+R +P    L+R C K+  +  N + I K ++ V+P  ALH D
Sbjct: 5   YDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--NGVFIPKGSMVVIPTYALHHD 62

Query: 342 ERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYT 401
            +++ + + F P+RF+ +  + I+ + + PFG G R CIG +FA + ++  L  +L+ ++
Sbjct: 63  PKYWTEPEEFRPERFSKKK-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 121

Query: 402 LVP 404
             P
Sbjct: 122 FKP 124


>D13705-1|BAA02864.1|  521|Homo sapiens fatty acid omega-hydroxylase
           protein.
          Length = 521

 Score = 89.4 bits (212), Expect = 2e-17
 Identities = 51/175 (29%), Positives = 91/175 (52%), Gaps = 6/175 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 325 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 383

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 384 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 442

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAG-LAWLLRKYTLVPQDYK-PVKFER 414
              +  +FLPF  G+R CIG +FA  +L+ G  A  L ++ L+P   + P+   R
Sbjct: 443 Q--HSHAFLPFSGGSRNCIGKQFAMNELKVGQQALTLVRFELLPDPTRIPIPIAR 495


>M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 88.2 bits (209), Expect = 5e-17
 Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 9/183 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT +V+ +TL  L  NP V KKL+ EID+      +T    D ++   LE  + E +R 
Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 302 YPPIGLLQRICTKETNLPSN--NLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA-P 358
            P   +L      + N+ S+     + K T  ++ + ALH +E+ + + D F P+RF  P
Sbjct: 364 RPVAPML---IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 359 ENFNEIN-KFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPVKFERSP 416
                I+   S+LPFG G R CIG   AR +L   +AWLL+++ L VP D +    E  P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 417 FAV 419
             V
Sbjct: 481 KVV 483


>M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 88.2 bits (209), Expect = 5e-17
 Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 9/183 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT +V+ +TL  L  NP V KKL+ EID+      +T    D ++   LE  + E +R 
Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 302 YPPIGLLQRICTKETNLPSN--NLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA-P 358
            P   +L      + N+ S+     + K T  ++ + ALH +E+ + + D F P+RF  P
Sbjct: 364 RPVAPML---IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 359 ENFNEIN-KFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPVKFERSP 416
                I+   S+LPFG G R CIG   AR +L   +AWLL+++ L VP D +    E  P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 417 FAV 419
             V
Sbjct: 481 KVV 483


>M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 88.2 bits (209), Expect = 5e-17
 Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 9/183 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT +V+ +TL  L  NP V KKL+ EID+      +T    D ++   LE  + E +R 
Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 302 YPPIGLLQRICTKETNLPSN--NLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA-P 358
            P   +L      + N+ S+     + K T  ++ + ALH +E+ + + D F P+RF  P
Sbjct: 364 RPVAPML---IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 359 ENFNEIN-KFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPVKFERSP 416
                I+   S+LPFG G R CIG   AR +L   +AWLL+++ L VP D +    E  P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 417 FAV 419
             V
Sbjct: 481 KVV 483


>M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score = 88.2 bits (209), Expect = 5e-17
 Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 9/183 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT +V+ +TL  L  NP V KKL+ EID+      +T    D ++   LE  + E +R 
Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 302 YPPIGLLQRICTKETNLPSN--NLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA-P 358
            P   +L      + N+ S+     + K T  ++ + ALH +E+ + + D F P+RF  P
Sbjct: 364 RPVAPML---IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 359 ENFNEIN-KFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPVKFERSP 416
                I+   S+LPFG G R CIG   AR +L   +AWLL+++ L VP D +    E  P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 417 FAV 419
             V
Sbjct: 481 KVV 483


>DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 88.2 bits (209), Expect = 5e-17
 Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 9/183 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT +V+ +TL  L  NP V KKL+ EID+      +T    D ++   LE  + E +R 
Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 302 YPPIGLLQRICTKETNLPSN--NLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA-P 358
            P   +L      + N+ S+     + K T  ++ + ALH +E+ + + D F P+RF  P
Sbjct: 364 RPVAPML---IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 359 ENFNEIN-KFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPVKFERSP 416
                I+   S+LPFG G R CIG   AR +L   +AWLL+++ L VP D +    E  P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 417 FAV 419
             V
Sbjct: 481 KVV 483


>BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 88.2 bits (209), Expect = 5e-17
 Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 9/183 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT +V+ +TL  L  NP V KKL+ EID+      +T    D ++   LE  + E +R 
Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 302 YPPIGLLQRICTKETNLPSN--NLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA-P 358
            P   +L      + N+ S+     + K T  ++ + ALH +E+ + + D F P+RF  P
Sbjct: 364 RPVAPML---IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 359 ENFNEIN-KFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPVKFERSP 416
                I+   S+LPFG G R CIG   AR +L   +AWLL+++ L VP D +    E  P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 417 FAV 419
             V
Sbjct: 481 KVV 483


>BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 88.2 bits (209), Expect = 5e-17
 Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 9/183 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT +V+ +TL  L  NP V KKL+ EID+      +T    D ++   LE  + E +R 
Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 302 YPPIGLLQRICTKETNLPSN--NLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA-P 358
            P   +L      + N+ S+     + K T  ++ + ALH +E+ + + D F P+RF  P
Sbjct: 364 RPVAPML---IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 359 ENFNEIN-KFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPVKFERSP 416
                I+   S+LPFG G R CIG   AR +L   +AWLL+++ L VP D +    E  P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 417 FAV 419
             V
Sbjct: 481 KVV 483


>BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 88.2 bits (209), Expect = 5e-17
 Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 9/183 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT +V+ +TL  L  NP V KKL+ EID+      +T    D ++   LE  + E +R 
Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 302 YPPIGLLQRICTKETNLPSN--NLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA-P 358
            P   +L      + N+ S+     + K T  ++ + ALH +E+ + + D F P+RF  P
Sbjct: 364 RPVAPML---IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 359 ENFNEIN-KFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPVKFERSP 416
                I+   S+LPFG G R CIG   AR +L   +AWLL+++ L VP D +    E  P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 417 FAV 419
             V
Sbjct: 481 KVV 483


>AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score = 88.2 bits (209), Expect = 5e-17
 Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 9/183 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT +V+ +TL  L  NP V KKL+ EID+      +T    D ++   LE  + E +R 
Sbjct: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 302 YPPIGLLQRICTKETNLPSN--NLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA-P 358
            P   +L      + N+ S+     + K T  ++ + ALH +E+ + + D F P+RF  P
Sbjct: 364 RPVAPML---IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 359 ENFNEIN-KFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPVKFERSP 416
                I+   S+LPFG G R CIG   AR +L   +AWLL+++ L VP D +    E  P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 417 FAV 419
             V
Sbjct: 481 KVV 483


>X16699-1|CAA34672.1|  511|Homo sapiens protein ( Human mRNA for
           cytochrome P-450HP. ).
          Length = 511

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 271 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 317

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 318 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 376

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 377 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 436 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 474


>J02871-1|AAA35712.1|  511|Homo sapiens protein ( Human lung
           cytochrome P450 (IV subfamily) BI protein, complete cds.
           ).
          Length = 511

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 271 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 317

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 318 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 376

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 377 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 436 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 474


>DQ518907-1|ABF47106.1|  511|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 511

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 271 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 317

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 318 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 376

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 377 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 436 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 474


>BC017758-1|AAH17758.1|  512|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 512

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 272 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 318

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 319 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 377

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 378 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 436

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 437 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 475


>AY151049-1|AAN72312.1|  497|Homo sapiens pulmonary cytochrome P450
           4B1 variant protein.
          Length = 497

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 257 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 303

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 304 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 362

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 363 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 421

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 422 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 460


>AY151048-1|AAN72311.1|  512|Homo sapiens pulmonary cytochrome P450
           4B1 protein.
          Length = 512

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 272 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 318

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 319 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 377

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 378 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 436

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 437 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 475


>AY064485-1|AAL57720.1|  511|Homo sapiens cytochrome P450 protein.
          Length = 511

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 271 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 317

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 318 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 376

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 377 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 436 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 474


>AL593856-7|CAI16983.1|  497|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 497

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 257 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 303

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 304 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 362

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 363 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 421

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 422 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 460


>AL593856-6|CAI16982.1|  512|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 512

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 272 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 318

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 319 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 377

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 378 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 436

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 437 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 475


>AL593856-5|CAI16981.1|  511|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 511

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 271 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 317

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 318 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 376

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 377 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 436 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 474


>AL356793-4|CAI22559.1|  511|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 511

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 271 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 317

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 318 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 376

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 377 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 436 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 474


>AL356793-3|CAI22557.1|  512|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 512

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 272 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 318

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 319 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 377

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 378 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 436

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 437 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 475


>AL356793-2|CAI22558.1|  497|Homo sapiens cytochrome P450, family 4,
           subfamily B, polypeptide 1 protein.
          Length = 497

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 257 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 303

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 304 DTTTSGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 362

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 363 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 421

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 422 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 460


>AF491285-1|AAM09532.1|  511|Homo sapiens cytochrome P450 protein.
          Length = 511

 Score = 86.6 bits (205), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 104/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 271 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 317

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT + + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 318 DTTTSGISWFLYCIALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 376

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 377 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 436 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 474


>AY064486-1|AAL57721.1|  511|Homo sapiens cytochrome P450 protein.
          Length = 511

 Score = 86.2 bits (204), Expect = 2e-16
 Identities = 56/219 (25%), Positives = 103/219 (47%), Gaps = 15/219 (6%)

Query: 182 DAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXXX 241
           + V+K ++NRR      DF+D+ L  ++ +         +I  +D  L            
Sbjct: 271 EKVRKKIQNRR----HLDFLDILLGARDED---------DIKLSDADLRAEVDTFMFEGH 317

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT   + + L  ++  P    +   E+ E+  D +    ++D+ K  YL M + E+ R 
Sbjct: 318 DTTTGGISWFLYCMALYPEHQHRCREEVREILGD-QDFFQWDDLGKMTYLTMCIKESFRL 376

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +K          +   ++  + + ALHR+   +P  + FD  RF+ EN 
Sbjct: 377 YPPVPQVYRQLSKPVTFVDGR-SLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENA 435

Query: 362 NEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           ++ + F+F+PF  G R CIG +FA  +++   A  L ++
Sbjct: 436 SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF 474


>BC100982-1|AAI00983.1|  280|Homo sapiens CYP3A43 protein protein.
          Length = 280

 Score = 85.8 bits (203), Expect = 3e-16
 Identities = 40/114 (35%), Positives = 71/114 (62%), Gaps = 3/114 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT+  + F + EL+++P V +KL  EID V  + K  + ++ + + +YL+MVVNET+R 
Sbjct: 168 DTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLRL 226

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQR 355
           +P +  + R+C K+  +  N + I K    +VP+ ALH D +++ + + F P+R
Sbjct: 227 FPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 278


>U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450
           monooxygenase CYP2J2 protein.
          Length = 502

 Score = 83.8 bits (198), Expect = 1e-15
 Identities = 99/405 (24%), Positives = 173/405 (42%), Gaps = 23/405 (5%)

Query: 9   LGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLS 68
           LG   A+++  L  I+  L    Q+F +R +    +     + L +     WK  R+   
Sbjct: 83  LGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTL 142

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            A  +  L  K++ E I+  A+   E I+   N Q  +  P   I    +  I +  FG 
Sbjct: 143 TALRNFGLGKKSLEERIQEEAQHLTEAIKEE-NGQPFD--PHFKINNAVSNIICSITFGE 199

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLDMMN---FDNYETSFID 182
             +    D+    + +   E T L++  T  L   FP ++K+L   +   F N++   + 
Sbjct: 200 RFEYQ--DSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLF 257

Query: 183 AVKKVLENRRAGE--KQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
               + ++R+     +  DFID  L+  +        + +E     E L           
Sbjct: 258 VSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHE-----ENLICSTLDLFFAG 312

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            +TT+  + + LL ++  P + +K+ AEID V   G++  +    +   Y   V++E  R
Sbjct: 313 TETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHEVQR 371

Query: 301 KYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               I L + R  T +T L   +L   K T+ +  + ALHRD   +   D F+P  F  E
Sbjct: 372 MGNIIPLNVPREVTVDTTLAGYHL--PKGTMILTNLTALHRDPTEWATPDTFNPDHFL-E 428

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           N     + +F+PF  G R C+G + AR +L      L++K+T  P
Sbjct: 429 NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP 473


>BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score = 83.8 bits (198), Expect = 1e-15
 Identities = 99/405 (24%), Positives = 173/405 (42%), Gaps = 23/405 (5%)

Query: 9   LGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLS 68
           LG   A+++  L  I+  L    Q+F +R +    +     + L +     WK  R+   
Sbjct: 83  LGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTL 142

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            A  +  L  K++ E I+  A+   E I+   N Q  +  P   I    +  I +  FG 
Sbjct: 143 TALRNFGLGKKSLEERIQEEAQHLTEAIKEE-NGQPFD--PHFKINNAVSNIICSITFGE 199

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLDMMN---FDNYETSFID 182
             +    D+    + +   E T L++  T  L   FP ++K+L   +   F N++   + 
Sbjct: 200 RFEYQ--DSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLF 257

Query: 183 AVKKVLENRRAGE--KQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
               + ++R+     +  DFID  L+  +        + +E     E L           
Sbjct: 258 VSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHE-----ENLICSTLDLFFAG 312

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            +TT+  + + LL ++  P + +K+ AEID V   G++  +    +   Y   V++E  R
Sbjct: 313 TETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHEVQR 371

Query: 301 KYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               I L + R  T +T L   +L   K T+ +  + ALHRD   +   D F+P  F  E
Sbjct: 372 MGNIIPLNVPREVTVDTTLAGYHL--PKGTMILTNLTALHRDPTEWATPDTFNPDHFL-E 428

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           N     + +F+PF  G R C+G + AR +L      L++K+T  P
Sbjct: 429 NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP 473


>AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score = 83.8 bits (198), Expect = 1e-15
 Identities = 99/405 (24%), Positives = 173/405 (42%), Gaps = 23/405 (5%)

Query: 9   LGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLS 68
           LG   A+++  L  I+  L    Q+F +R +    +     + L +     WK  R+   
Sbjct: 83  LGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTL 142

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            A  +  L  K++ E I+  A+   E I+   N Q  +  P   I    +  I +  FG 
Sbjct: 143 TALRNFGLGKKSLEERIQEEAQHLTEAIKEE-NGQPFD--PHFKINNAVSNIICSITFGE 199

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLDMMN---FDNYETSFID 182
             +    D+    + +   E T L++  T  L   FP ++K+L   +   F N++   + 
Sbjct: 200 RFEYQ--DSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLF 257

Query: 183 AVKKVLENRRAGE--KQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
               + ++R+     +  DFID  L+  +        + +E     E L           
Sbjct: 258 VSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHE-----ENLICSTLDLFFAG 312

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            +TT+  + + LL ++  P + +K+ AEID V   G++  +    +   Y   V++E  R
Sbjct: 313 TETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHEVQR 371

Query: 301 KYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               I L + R  T +T L   +L   K T+ +  + ALHRD   +   D F+P  F  E
Sbjct: 372 MGNIIPLNVPREVTVDTTLAGYHL--PKGTMILTNLTALHRDPTEWATPDTFNPDHFL-E 428

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           N     + +F+PF  G R C+G + AR +L      L++K+T  P
Sbjct: 429 NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP 473


>AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.
          Length = 502

 Score = 83.8 bits (198), Expect = 1e-15
 Identities = 99/405 (24%), Positives = 173/405 (42%), Gaps = 23/405 (5%)

Query: 9   LGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLS 68
           LG   A+++  L  I+  L    Q+F +R +    +     + L +     WK  R+   
Sbjct: 83  LGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTL 142

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            A  +  L  K++ E I+  A+   E I+   N Q  +  P   I    +  I +  FG 
Sbjct: 143 TALRNFGLGKKSLEERIQEEAQHLTEAIKEE-NGQPFD--PHFKINNAVSNIICSITFGE 199

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLDMMN---FDNYETSFID 182
             +    D+    + +   E T L++  T  L   FP ++K+L   +   F N++   + 
Sbjct: 200 RFEYQ--DSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLF 257

Query: 183 AVKKVLENRRAGE--KQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
               + ++R+     +  DFID  L+  +        + +E     E L           
Sbjct: 258 VSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHE-----ENLICSTLDLFFAG 312

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            +TT+  + + LL ++  P + +K+ AEID V   G++  +    +   Y   V++E  R
Sbjct: 313 TETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQP-STAARESMPYTNAVIHEVQR 371

Query: 301 KYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               I L + R  T +T L   +L   K T+ +  + ALHRD   +   D F+P  F  E
Sbjct: 372 MGNIIPLNVPREVTVDTTLAGYHL--PKGTMILTNLTALHRDPTEWATPDTFNPDHFL-E 428

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           N     + +F+PF  G R C+G + AR +L      L++K+T  P
Sbjct: 429 NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP 473


>AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2
           protein.
          Length = 502

 Score = 82.2 bits (194), Expect = 3e-15
 Identities = 98/405 (24%), Positives = 172/405 (42%), Gaps = 23/405 (5%)

Query: 9   LGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLS 68
           LG   A+++  L  I+  L    Q+F +R +    +     + L +     WK  R+   
Sbjct: 83  LGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTL 142

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            A  +  L  K++ E I+  A+   E I+   N Q  +  P   I    +  I +  FG 
Sbjct: 143 TALRNFGLGKKSLEERIQEEAQHLTEAIKEE-NGQPFD--PHFKINNAVSNIICSITFGE 199

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLDMMN---FDNYETSFID 182
             +    D+    + +   E T L++  T  L   FP ++K+L   +   F N++   + 
Sbjct: 200 RFEYQ--DSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLF 257

Query: 183 AVKKVLENRRAGE--KQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXXX 240
               + ++R+     +  DFID  L+  +        + +E     E L           
Sbjct: 258 VSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHE-----ENLICSTLDLFFAG 312

Query: 241 XDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR 300
            +TT+  + + LL ++  P + +K+  EID V   G++  +    +   Y   V++E  R
Sbjct: 313 TETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQP-STAARESMPYTNAVIHEVQR 371

Query: 301 KYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               I L + R  T +T L   +L   K T+ +  + ALHRD   +   D F+P  F  E
Sbjct: 372 MGNIIPLNVPREVTVDTTLAGYHL--PKGTMILTNLTALHRDPTEWATPDTFNPDHFL-E 428

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           N     + +F+PF  G R C+G + AR +L      L++K+T  P
Sbjct: 429 NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP 473


>AY288916-1|AAP31972.1|  508|Homo sapiens cytochrome P450, family
           27, subfamily B, polypeptide 1 protein.
          Length = 508

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL-NFEDMDKFKYLEMVVNETMR 300
           DT +N + + L ELS +P V   LH+EI      G     +   + +   L+ VV E +R
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            YP +    R+  K+ ++   +  I K+T+  +   A  RD   +P+ ++F P R+  E 
Sbjct: 380 LYPVVPGNSRVPDKDIHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQ 405
               + F+ LPFG G R C+G + A L+L+  LA +L  + + P+
Sbjct: 438 PTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE 481


>AF256213-1|AAG00416.1|  508|Homo sapiens 25- hydroxyvitamin
           D-1-alpha-hydroxylase protein.
          Length = 508

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL-NFEDMDKFKYLEMVVNETMR 300
           DT +N + + L ELS +P V   LH+EI      G     +   + +   L+ VV E +R
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            YP +    R+  K+ ++   +  I K+T+  +   A  RD   +P+ ++F P R+  E 
Sbjct: 380 LYPVVPGNSRVPDKDIHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQ 405
               + F+ LPFG G R C+G + A L+L+  LA +L  + + P+
Sbjct: 438 PTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE 481


>AF246895-1|AAF64299.1|  508|Homo sapiens 25-hydroxyvitamin
           D-1-alpha-hydroxylase protein.
          Length = 508

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL-NFEDMDKFKYLEMVVNETMR 300
           DT +N + + L ELS +P V   LH+EI      G     +   + +   L+ VV E +R
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            YP +    R+  K+ ++   +  I K+T+  +   A  RD   +P+ ++F P R+  E 
Sbjct: 380 LYPVVPGNSRVPDKDIHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQ 405
               + F+ LPFG G R C+G + A L+L+  LA +L  + + P+
Sbjct: 438 PTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE 481


>AF027152-1|AAC51854.1|  508|Homo sapiens P450 25-hydroxyvitamin D-1
           alpha hydroxylase protein.
          Length = 508

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL-NFEDMDKFKYLEMVVNETMR 300
           DT +N + + L ELS +P V   LH+EI      G     +   + +   L+ VV E +R
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            YP +    R+  K+ ++   +  I K+T+  +   A  RD   +P+ ++F P R+  E 
Sbjct: 380 LYPVVPGNSRVPDKDIHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQ 405
               + F+ LPFG G R C+G + A L+L+  LA +L  + + P+
Sbjct: 438 PTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE 481


>AF020192-1|AAC51853.1|  508|Homo sapiens 25-hydroxyvitamin
           D-1-alpha-hydroxylase protein.
          Length = 508

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL-NFEDMDKFKYLEMVVNETMR 300
           DT +N + + L ELS +P V   LH+EI      G     +   + +   L+ VV E +R
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            YP +    R+  K+ ++   +  I K+T+  +   A  RD   +P+ ++F P R+  E 
Sbjct: 380 LYPVVPGNSRVPDKDIHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQ 405
               + F+ LPFG G R C+G + A L+L+  LA +L  + + P+
Sbjct: 438 PTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE 481


>AB006987-1|BAA23418.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1-alpha-hydroxylase protein.
          Length = 508

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL-NFEDMDKFKYLEMVVNETMR 300
           DT +N + + L ELS +P V   LH+EI      G     +   + +   L+ VV E +R
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            YP +    R+  K+ ++   +  I K+T+  +   A  RD   +P+ ++F P R+  E 
Sbjct: 380 LYPVVPGNSRVPDKDIHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQ 405
               + F+ LPFG G R C+G + A L+L+  LA +L  + + P+
Sbjct: 438 PTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE 481


>AB005990-1|BAA22657.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1alpha-hydroxylase protein.
          Length = 508

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL-NFEDMDKFKYLEMVVNETMR 300
           DT +N + + L ELS +P V   LH+EI      G     +   + +   L+ VV E +R
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            YP +    R+  K+ ++   +  I K+T+  +   A  RD   +P+ ++F P R+  E 
Sbjct: 380 LYPVVPGNSRVPDKDIHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQ 405
               + F+ LPFG G R C+G + A L+L+  LA +L  + + P+
Sbjct: 438 PTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE 481


>AB005989-1|BAA22656.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1alpha-hydroxylase protein.
          Length = 508

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL-NFEDMDKFKYLEMVVNETMR 300
           DT +N + + L ELS +P V   LH+EI      G     +   + +   L+ VV E +R
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            YP +    R+  K+ ++   +  I K+T+  +   A  RD   +P+ ++F P R+  E 
Sbjct: 380 LYPVVPGNSRVPDKDIHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQ 405
               + F+ LPFG G R C+G + A L+L+  LA +L  + + P+
Sbjct: 438 PTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE 481


>AB005038-1|BAA23416.1|  508|Homo sapiens 25-hydroxyvitamin D3
           1-alpha-hydroxylase protein.
          Length = 508

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTL-NFEDMDKFKYLEMVVNETMR 300
           DT +N + + L ELS +P V   LH+EI      G     +   + +   L+ VV E +R
Sbjct: 320 DTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLR 379

Query: 301 KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
            YP +    R+  K+ ++   +  I K+T+  +   A  RD   +P+ ++F P R+  E 
Sbjct: 380 LYPVVPGNSRVPDKDIHV--GDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEG 437

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQ 405
               + F+ LPFG G R C+G + A L+L+  LA +L  + + P+
Sbjct: 438 PTP-HPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE 481


>AY178622-1|AAO21126.1|  531|Homo sapiens steroid hydroxylase
           protein.
          Length = 531

 Score = 78.6 bits (185), Expect = 4e-14
 Identities = 51/166 (30%), Positives = 83/166 (50%), Gaps = 7/166 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT+N + + L  LS +P + K LH E+  V   G+   + +D      L+ V+ ET+R 
Sbjct: 338 DTTSNTLTWALYHLSKDPEIQKALHEEVVGVVPAGQVPQH-KDFAHMPLLKAVLKETLRL 396

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA---- 357
           YP +    RI  KE  +  +     K+T  V     + RD   + + ++F P R+     
Sbjct: 397 YPVVPTNSRIIEKEIEV--DGFLFPKNTQFVFCHYEVSRDPTAFSEPESFQPHRWLRNSQ 454

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLV 403
           P      + F  +PFG G R C+G + A L+++  LA L++KY +V
Sbjct: 455 PATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 500


>M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.
          Length = 490

 Score = 77.8 bits (183), Expect = 7e-14
 Identities = 63/248 (25%), Positives = 108/248 (43%), Gaps = 15/248 (6%)

Query: 156 FLAGTFPRLIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRD 215
           +  GT  +L+K L  M     E+  ++ VK+  E+      + DFID C  ++  +  ++
Sbjct: 225 YFPGTHNKLLKNLAFM-----ESDILEKVKEHQESMDINNPR-DFID-CFLIKMEKEKQN 277

Query: 216 LVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQD 275
             + + I    E L            +TT+  + + LL L  +P V  K+  EI+ V   
Sbjct: 278 QQSEFTI----ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGR 333

Query: 276 GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVP 334
            +     +D     Y + VV+E  R    I   L    T +      N  I K T  +  
Sbjct: 334 NRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF--RNYLIPKGTTILTS 390

Query: 335 VLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLA 394
           + ++  D + +P  + FDP+ F  E  N      F+PF  G R+C+G   AR++L   L 
Sbjct: 391 LTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT 450

Query: 395 WLLRKYTL 402
           ++L+ + L
Sbjct: 451 FILQNFNL 458


>AL135960-9|CAI19736.1|  421|Homo sapiens cytochrome P450, family 4,
           subfamily A, polypeptide 22 protein.
          Length = 421

 Score = 77.8 bits (183), Expect = 7e-14
 Identities = 40/131 (30%), Positives = 67/131 (51%), Gaps = 4/131 (3%)

Query: 285 MDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERF 344
           +D+  Y  M + E +R YPP+  + R  +     P     + K  + ++ +  LH + + 
Sbjct: 268 LDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKV 326

Query: 345 YPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
           +P  + FDP RFAP +    +  +FLPF  G+R CIG +FA  QL+   A  L ++ L+P
Sbjct: 327 WPNLEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP 384

Query: 405 QDYK-PVKFER 414
              + P+   R
Sbjct: 385 DPTRIPIPMAR 395


>X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase
           protein.
          Length = 530

 Score = 77.4 bits (182), Expect = 9e-14
 Identities = 50/166 (30%), Positives = 83/166 (50%), Gaps = 7/166 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT+N + + L  LS +P + + LH E+  V   G+   + +D      L+ V+ ET+R 
Sbjct: 337 DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQH-KDFAHMPLLKAVLKETLRL 395

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA---- 357
           YP +    RI  KE  +  +     K+T  V     + RD   + + ++F P R+     
Sbjct: 396 YPVVPTNSRIIEKEIEV--DGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQ 453

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLV 403
           P      + F  +PFG G R C+G + A L+++  LA L++KY +V
Sbjct: 454 PATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 499


>M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase
           protein.
          Length = 531

 Score = 77.4 bits (182), Expect = 9e-14
 Identities = 50/166 (30%), Positives = 83/166 (50%), Gaps = 7/166 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT+N + + L  LS +P + + LH E+  V   G+   + +D      L+ V+ ET+R 
Sbjct: 338 DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQH-KDFAHMPLLKAVLKETLRL 396

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA---- 357
           YP +    RI  KE  +  +     K+T  V     + RD   + + ++F P R+     
Sbjct: 397 YPVVPTNSRIIEKEIEV--DGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQ 454

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLV 403
           P      + F  +PFG G R C+G + A L+++  LA L++KY +V
Sbjct: 455 PATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 500


>L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.
          Length = 468

 Score = 77.4 bits (182), Expect = 9e-14
 Identities = 63/248 (25%), Positives = 108/248 (43%), Gaps = 15/248 (6%)

Query: 156 FLAGTFPRLIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRD 215
           +  GT  +L+K L  M     E+  ++ VK+  E+      + DFID C  ++  +  ++
Sbjct: 203 YFPGTHNKLLKNLAFM-----ESDILEKVKEHQESMDINNPR-DFID-CFLIKMEKEKQN 255

Query: 216 LVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQD 275
             + + I    E L            +TT+  + + LL L  +P V  K+  EI+ V   
Sbjct: 256 QQSEFTI----ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGR 311

Query: 276 GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVP 334
            +     +D     Y + VV+E  R    I   L    T +      N  I K T  +  
Sbjct: 312 NRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF--RNYLIPKGTTILTS 368

Query: 335 VLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLA 394
           + ++  D + +P  + FDP+ F  E  N      F+PF  G R+C+G   AR++L   L 
Sbjct: 369 LTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT 428

Query: 395 WLLRKYTL 402
           ++L+ + L
Sbjct: 429 FILQNFNL 436


>BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family
           27, subfamily A, polypeptide 1 protein.
          Length = 531

 Score = 77.4 bits (182), Expect = 9e-14
 Identities = 50/166 (30%), Positives = 83/166 (50%), Gaps = 7/166 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT+N + + L  LS +P + + LH E+  V   G+   + +D      L+ V+ ET+R 
Sbjct: 338 DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQH-KDFAHMPLLKAVLKETLRL 396

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA---- 357
           YP +    RI  KE  +  +     K+T  V     + RD   + + ++F P R+     
Sbjct: 397 YPVVPTNSRIIEKEIEV--DGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQ 454

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLV 403
           P      + F  +PFG G R C+G + A L+++  LA L++KY +V
Sbjct: 455 PATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 500


>BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family
           27, subfamily A, polypeptide 1 protein.
          Length = 531

 Score = 77.4 bits (182), Expect = 9e-14
 Identities = 50/166 (30%), Positives = 83/166 (50%), Gaps = 7/166 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTT+N + + L  LS +P + + LH E+  V   G+   + +D      L+ V+ ET+R 
Sbjct: 338 DTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQH-KDFAHMPLLKAVLKETLRL 396

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA---- 357
           YP +    RI  KE  +  +     K+T  V     + RD   + + ++F P R+     
Sbjct: 397 YPVVPTNSRIIEKEIEV--DGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQ 454

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLV 403
           P      + F  +PFG G R C+G + A L+++  LA L++KY +V
Sbjct: 455 PATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVV 500


>AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score = 77.4 bits (182), Expect = 9e-14
 Identities = 63/248 (25%), Positives = 108/248 (43%), Gaps = 15/248 (6%)

Query: 156 FLAGTFPRLIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRD 215
           +  GT  +L+K L  M     E+  ++ VK+  E+      + DFID C  ++  +  ++
Sbjct: 225 YFPGTHNKLLKNLAFM-----ESDILEKVKEHQESMDINNPR-DFID-CFLIKMEKEKQN 277

Query: 216 LVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQD 275
             + + I    E L            +TT+  + + LL L  +P V  K+  EI+ V   
Sbjct: 278 QQSEFTI----ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGR 333

Query: 276 GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVP 334
            +     +D     Y + VV+E  R    I   L    T +      N  I K T  +  
Sbjct: 334 NRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF--RNYLIPKGTTILTS 390

Query: 335 VLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLA 394
           + ++  D + +P  + FDP+ F  E  N      F+PF  G R+C+G   AR++L   L 
Sbjct: 391 LTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT 450

Query: 395 WLLRKYTL 402
           ++L+ + L
Sbjct: 451 FILQNFNL 458


>AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score = 77.4 bits (182), Expect = 9e-14
 Identities = 63/248 (25%), Positives = 108/248 (43%), Gaps = 15/248 (6%)

Query: 156 FLAGTFPRLIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRD 215
           +  GT  +L+K L  M     E+  ++ VK+  E+      + DFID C  ++  +  ++
Sbjct: 225 YFPGTHNKLLKNLAFM-----ESDILEKVKEHQESMDINNPR-DFID-CFLIKMEKEKQN 277

Query: 216 LVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQD 275
             + + I    E L            +TT+  + + LL L  +P V  K+  EI+ V   
Sbjct: 278 QQSEFTI----ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGR 333

Query: 276 GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVP 334
            +     +D     Y + VV+E  R    I   L    T +      N  I K T  +  
Sbjct: 334 NRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF--RNYLIPKGTTILTS 390

Query: 335 VLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLA 394
           + ++  D + +P  + FDP+ F  E  N      F+PF  G R+C+G   AR++L   L 
Sbjct: 391 LTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT 450

Query: 395 WLLRKYTL 402
           ++L+ + L
Sbjct: 451 FILQNFNL 458


>AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score = 77.4 bits (182), Expect = 9e-14
 Identities = 63/248 (25%), Positives = 108/248 (43%), Gaps = 15/248 (6%)

Query: 156 FLAGTFPRLIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRD 215
           +  GT  +L+K L  M     E+  ++ VK+  E+      + DFID C  ++  +  ++
Sbjct: 225 YFPGTHNKLLKNLAFM-----ESDILEKVKEHQESMDINNPR-DFID-CFLIKMEKEKQN 277

Query: 216 LVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQD 275
             + + I    E L            +TT+  + + LL L  +P V  K+  EI+ V   
Sbjct: 278 QQSEFTI----ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGR 333

Query: 276 GKKTLNFEDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVP 334
            +     +D     Y + VV+E  R    I   L    T +      N  I K T  +  
Sbjct: 334 NRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF--RNYLIPKGTTILTS 390

Query: 335 VLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLA 394
           + ++  D + +P  + FDP+ F  E  N      F+PF  G R+C+G   AR++L   L 
Sbjct: 391 LTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT 450

Query: 395 WLLRKYTL 402
           ++L+ + L
Sbjct: 451 FILQNFNL 458


>X71480-1|CAA50586.1|  141|Homo sapiens cytochrome P450 protein.
          Length = 141

 Score = 75.4 bits (177), Expect = 4e-13
 Identities = 39/138 (28%), Positives = 70/138 (50%), Gaps = 4/138 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 8   DTTASGISWILYALATHPKHQERCREEIHGLLGDGA-SITWNHLDQMPYTTMCIKEALRL 66

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K    ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 67  YPPVPGISRELSTPVTFPDGR-SLPKGITVMLSIYGLHHNPKVWPNPEVFDPSRFAPGSA 125

Query: 362 NEINKFSFLPFGEGNRVC 379
              +  +FLPF  G+R C
Sbjct: 126 Q--HSHAFLPFSGGSRNC 141


>M32879-1|AAA52149.1|  503|Homo sapiens CYP11B1 protein.
          Length = 503

 Score = 74.9 bits (176), Expect = 5e-13
 Identities = 89/372 (23%), Positives = 165/372 (44%), Gaps = 29/372 (7%)

Query: 52  LFIDDLPRWKILRQKLSP-AFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEE 105
           +F+ + P W+  R +L+P   S   ++     ++  ARDF +      ++N+     L+ 
Sbjct: 129 VFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDV 188

Query: 106 MPFNAIYKYTTGSIGAAVFG--VDVDQNTLDTPALNITRKALEPTLKSIMTFFLAGTFPR 163
            P  +I+ YT  +   A+FG  + +  ++  + +LN    ALE   KS +        PR
Sbjct: 189 QP--SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH-ALEVMFKSTVQLMF---MPR 242

Query: 164 -LIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEI 222
            L +W     +  +  ++ D + +  +N    +K Y  +      Q   ++ +L+   E+
Sbjct: 243 SLSRWTSPKVWKEHFEAW-DCIFQYGDN--CIQKIYQELAFSRPQQYTSIVAELLLNAEL 299

Query: 223 VPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNF 282
            P  + +            DTT   +  TL EL+ NP+V + L  E         +    
Sbjct: 300 SP--DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ- 356

Query: 283 EDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRD 341
           +   +   L   + ET+R YP +GL L+R+ + +  L   N  I   T+  V + +L R+
Sbjct: 357 KATTELPLLRAALKETLRLYP-VGLFLERVASSDLVL--QNYHIPAGTLVRVFLYSLGRN 413

Query: 342 ERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY- 400
              +P+ + ++PQR+     +  N F  +PFG G R C+G + A  ++   L  +L+   
Sbjct: 414 PALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472

Query: 401 --TLVPQDYKPV 410
             TL  +D K V
Sbjct: 473 VETLTQEDIKMV 484


>BC096287-1|AAH96287.1|  503|Homo sapiens cytochrome P450, family
           11, subfamily B, polypeptide 1 protein.
          Length = 503

 Score = 74.9 bits (176), Expect = 5e-13
 Identities = 89/372 (23%), Positives = 165/372 (44%), Gaps = 29/372 (7%)

Query: 52  LFIDDLPRWKILRQKLSP-AFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEE 105
           +F+ + P W+  R +L+P   S   ++     ++  ARDF +      ++N+     L+ 
Sbjct: 129 VFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDV 188

Query: 106 MPFNAIYKYTTGSIGAAVFG--VDVDQNTLDTPALNITRKALEPTLKSIMTFFLAGTFPR 163
            P  +I+ YT  +   A+FG  + +  ++  + +LN    ALE   KS +        PR
Sbjct: 189 QP--SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH-ALEVMFKSTVQLMF---MPR 242

Query: 164 -LIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEI 222
            L +W     +  +  ++ D + +  +N    +K Y  +      Q   ++ +L+   E+
Sbjct: 243 SLSRWTSPKVWKEHFEAW-DCIFQYGDN--CIQKIYQELAFSRPQQYTSIVAELLLNAEL 299

Query: 223 VPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNF 282
            P  + +            DTT   +  TL EL+ NP+V + L  E         +    
Sbjct: 300 SP--DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ- 356

Query: 283 EDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRD 341
           +   +   L   + ET+R YP +GL L+R+ + +  L   N  I   T+  V + +L R+
Sbjct: 357 KATTELPLLRAALKETLRLYP-VGLFLERVASSDLVL--QNYHIPAGTLVRVFLYSLGRN 413

Query: 342 ERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY- 400
              +P+ + ++PQR+     +  N F  +PFG G R C+G + A  ++   L  +L+   
Sbjct: 414 PALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472

Query: 401 --TLVPQDYKPV 410
             TL  +D K V
Sbjct: 473 VETLTQEDIKMV 484


>BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family 2,
           subfamily W, polypeptide 1 protein.
          Length = 490

 Score = 74.9 bits (176), Expect = 5e-13
 Identities = 50/177 (28%), Positives = 84/177 (47%), Gaps = 6/177 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + +  L +  +P V  ++  E+D V   G+ T   ED     Y   V++E  R 
Sbjct: 299 ETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGR-TPRLEDQQALPYTSAVLHEVQRF 357

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAPEN 360
              +  + R    +T L      + K T  V+P+L ++  DE  +     F+P  F   N
Sbjct: 358 ITLLPHVPRCTAADTQL--GGFLLPKGT-PVIPLLTSVLLDETQWQTPGQFNPGHFLDAN 414

Query: 361 FNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLV-PQDYKPVKFERSP 416
            + + + +FLPF  G RVC+G + AR +L    A LL++Y L+ P    P   + +P
Sbjct: 415 GHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP 471


>AF478474-1|AAL84813.1|  503|Homo sapiens mutated cytochrome
           P-450c11 protein protein.
          Length = 503

 Score = 74.9 bits (176), Expect = 5e-13
 Identities = 89/372 (23%), Positives = 165/372 (44%), Gaps = 29/372 (7%)

Query: 52  LFIDDLPRWKILRQKLSP-AFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEE 105
           +F+ + P W+  R +L+P   S   ++     ++  ARDF +      ++N+     L+ 
Sbjct: 129 VFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDV 188

Query: 106 MPFNAIYKYTTGSIGAAVFG--VDVDQNTLDTPALNITRKALEPTLKSIMTFFLAGTFPR 163
            P  +I+ YT  +   A+FG  + +  ++  + +LN    ALE   KS +        PR
Sbjct: 189 QP--SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH-ALEVMFKSTVQLMF---MPR 242

Query: 164 -LIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEI 222
            L +W     +  +  ++ D + +  +N    +K Y  +      Q   ++ +L+   E+
Sbjct: 243 SLSRWTSPKVWKEHFEAW-DCIFQYGDN--CIQKIYQELAFSRPQQYTSIVAELLLNAEL 299

Query: 223 VPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNF 282
            P  + +            DTT   +  TL EL+ NP+V + L  E         +    
Sbjct: 300 SP--DAIKANSMELTAGSMDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ- 356

Query: 283 EDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRD 341
           +   +   L   + ET+R YP +GL L+R+ + +  L   N  I   T+  V + +L R+
Sbjct: 357 KATTELPLLRAALKETLRLYP-VGLFLERVASSDLVL--QNYHIPAGTLVRVFLYSLGRN 413

Query: 342 ERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY- 400
              +P+ + ++PQR+     +  N F  +PFG G R C+G + A  ++   L  +L+   
Sbjct: 414 PALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472

Query: 401 --TLVPQDYKPV 410
             TL  +D K V
Sbjct: 473 VETLTQEDIKMV 484


>X55764-1|CAA39290.1|  503|Homo sapiens protein ( Human mRNA for
           cytochrome P-450 (11 Beta). ).
          Length = 503

 Score = 74.5 bits (175), Expect = 6e-13
 Identities = 89/372 (23%), Positives = 165/372 (44%), Gaps = 29/372 (7%)

Query: 52  LFIDDLPRWKILRQKLSP-AFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEE 105
           +F+ + P W+  R +L+P   S   ++     ++  ARDF +      ++N+     L+ 
Sbjct: 129 VFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDV 188

Query: 106 MPFNAIYKYTTGSIGAAVFG--VDVDQNTLDTPALNITRKALEPTLKSIMTFFLAGTFPR 163
            P  +I+ YT  +   A+FG  + +  ++  + +LN    ALE   KS +        PR
Sbjct: 189 QP--SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH-ALEVMFKSTVQLMF---MPR 242

Query: 164 -LIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEI 222
            L +W     +  +  ++ D + +  +N    +K Y  +      Q   ++ +L+   E+
Sbjct: 243 SLSRWTSPKVWKEHFEAW-DCIFQYGDN--CIQKIYQELAFSRPQQYTSIVAELLLNAEL 299

Query: 223 VPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNF 282
            P  + +            DTT   +  TL EL+ NP+V + L  E         +    
Sbjct: 300 SP--DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ- 356

Query: 283 EDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRD 341
           +   +   L   + ET+R YP +GL L+R+ + +  L   N  I   T+  V + +L R+
Sbjct: 357 KATTELPLLRAALKETLRLYP-VGLFLERVVSSDLVL--QNYHIPAGTLVRVFLYSLGRN 413

Query: 342 ERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY- 400
              +P+ + ++PQR+     +  N F  +PFG G R C+G + A  ++   L  +L+   
Sbjct: 414 PALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472

Query: 401 --TLVPQDYKPV 410
             TL  +D K V
Sbjct: 473 VETLTQEDIKMV 484


>BC096285-1|AAH96285.1|  574|Homo sapiens CYP11B1 protein protein.
          Length = 574

 Score = 74.1 bits (174), Expect = 9e-13
 Identities = 88/366 (24%), Positives = 161/366 (43%), Gaps = 29/366 (7%)

Query: 58  PRWKILRQKLSP-AFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEEMPFNAI 111
           P W+  R +L+P   S   ++     ++  ARDF +      ++N+     L+  P  +I
Sbjct: 206 PEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP--SI 263

Query: 112 YKYTTGSIGAAVFG--VDVDQNTLDTPALNITRKALEPTLKSIMTFFLAGTFPR-LIKWL 168
           + YT  +   A+FG  + +  ++  + +LN    ALE   KS +        PR L +W 
Sbjct: 264 FHYTIEASNLALFGERLGLVGHSPSSASLNFLH-ALEVMFKSTVQLMF---MPRSLSRWT 319

Query: 169 DMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDEL 228
               +  +  ++ D + +  +N    +K Y  +      Q   ++ +L+   E+ P  + 
Sbjct: 320 SPKVWKEHFEAW-DCIFQYGDN--CIQKIYQELAFSRPQQYTSIVAELLLNAELSP--DA 374

Query: 229 LXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKF 288
           +            DTT   +  TL EL+ NP+V + L  E         +    +   + 
Sbjct: 375 IKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ-KATTEL 433

Query: 289 KYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPK 347
             L   + ET+R YP +GL L+R+ + +  L   N  I   T+  V + +L R+   +P+
Sbjct: 434 PLLRAALKETLRLYP-VGLFLERVASSDLVL--QNYHIPAGTLVRVFLYSLGRNPALFPR 490

Query: 348 SDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY---TLVP 404
            + ++PQR+     +  N F  +PFG G R C+G + A  ++   L  +L+     TL  
Sbjct: 491 PERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ 549

Query: 405 QDYKPV 410
           +D K V
Sbjct: 550 EDIKMV 555


>X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120
           AA) protein.
          Length = 210

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 49/167 (29%), Positives = 77/167 (46%), Gaps = 6/167 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT+  + + LL L  +P V  K+  EID V    +     +D     Y + VV+E  R 
Sbjct: 20  ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDAVVHEIQRY 78

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P G+   + T +T     N  I K T  +  + ++  D+R +P  + FDP  F  +
Sbjct: 79  SDLVPTGVPHAVTT-DTKF--RNYLIPKGTTIMALLTSVLHDDREFPNPNIFDPGHFLDK 135

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQD 406
           N N      F+PF  G R+C G   AR++L   L  +L+ + L   D
Sbjct: 136 NGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD 182


>S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.
          Length = 477

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 95/414 (22%), Positives = 168/414 (40%), Gaps = 38/414 (9%)

Query: 7   FTL--GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKIL 63
           FTL  G +P ++L     ++  L    + F  RGI  L+E+      I+F +   +WK +
Sbjct: 52  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEI 110

Query: 64  RQKLSPAFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEEMPFNAIYKYTTGS 118
           R+     FS + L+    G +RS  D V+      +E     +     P   +       
Sbjct: 111 RR-----FSLMTLRNFGMG-KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 164

Query: 119 IGAAVFGVDVDQNTLDTPALNITRKALEPTLKSIMTFFL--AGTFPRLIKWLD------M 170
           I + +F    D    D   LN+  K L   +K + + ++     F  +I +        +
Sbjct: 165 ICSIIFHKRFDYK--DQQFLNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 221

Query: 171 MNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLX 230
            N    ++  ++ VK+  E+      Q DFID C  ++  +   +  + + I    E L 
Sbjct: 222 KNVAFMKSYILEKVKEHQESMDMNNPQ-DFID-CFLMKMEKEKHNQPSEFTI----ESLE 275

Query: 231 XXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKY 290
                      +TT+  + + LL L  +P V  K+  EI+ V    +     +D     Y
Sbjct: 276 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRSHMPY 334

Query: 291 LEMVVNETMRKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKS 348
            + VV+E  R     P  L   +     ++   N  I K T  ++ + ++  D + +P  
Sbjct: 335 TDAVVHEVQRYIDLLPTSLPHAVTC---DIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 391

Query: 349 DAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           + FDP  F  E  N      F+PF  G R+C+G   A ++L   L  +L+ + L
Sbjct: 392 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 445


>M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.
          Length = 370

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 48/179 (26%), Positives = 77/179 (43%), Gaps = 4/179 (2%)

Query: 225 TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFED 284
           T E L            +TT+  + + LL L  +P V  K+  EI+ V    +     +D
Sbjct: 163 TVESLIATVTDMFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC-MQD 221

Query: 285 MDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRDER 343
                Y + VV+E  R    I   L    T +      N  I K T  +  + ++  D +
Sbjct: 222 RSHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF--RNYLIPKGTTILTSLTSVLHDNK 279

Query: 344 FYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
            +P  + FDP+ F  E  N      F+PF  G R+C+G   AR++L   L ++L+ + L
Sbjct: 280 EFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 338


>D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.
          Length = 487

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 95/414 (22%), Positives = 168/414 (40%), Gaps = 38/414 (9%)

Query: 7   FTL--GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKIL 63
           FTL  G +P ++L     ++  L    + F  RGI  L+E+      I+F +   +WK +
Sbjct: 62  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEI 120

Query: 64  RQKLSPAFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEEMPFNAIYKYTTGS 118
           R+     FS + L+    G +RS  D V+      +E     +     P   +       
Sbjct: 121 RR-----FSLMTLRNFGMG-KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 174

Query: 119 IGAAVFGVDVDQNTLDTPALNITRKALEPTLKSIMTFFL--AGTFPRLIKWLD------M 170
           I + +F    D    D   LN+  K L   +K + + ++     F  +I +        +
Sbjct: 175 ICSIIFHKRFDYK--DQQFLNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 231

Query: 171 MNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLX 230
            N    ++  ++ VK+  E+      Q DFID C  ++  +   +  + + I    E L 
Sbjct: 232 KNVAFMKSYILEKVKEHQESMDMNNPQ-DFID-CFLMKMEKEKHNQPSEFTI----ESLE 285

Query: 231 XXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKY 290
                      +TT+  + + LL L  +P V  K+  EI+ V    +     +D     Y
Sbjct: 286 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRSHMPY 344

Query: 291 LEMVVNETMRKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKS 348
            + VV+E  R     P  L   +     ++   N  I K T  ++ + ++  D + +P  
Sbjct: 345 TDAVVHEVQRYIDLLPTSLPHAVTC---DIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 401

Query: 349 DAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           + FDP  F  E  N      F+PF  G R+C+G   A ++L   L  +L+ + L
Sbjct: 402 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 455


>BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 95/414 (22%), Positives = 168/414 (40%), Gaps = 38/414 (9%)

Query: 7   FTL--GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKIL 63
           FTL  G +P ++L     ++  L    + F  RGI  L+E+      I+F +   +WK +
Sbjct: 65  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEI 123

Query: 64  RQKLSPAFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEEMPFNAIYKYTTGS 118
           R+     FS + L+    G +RS  D V+      +E     +     P   +       
Sbjct: 124 RR-----FSLMTLRNFGMG-KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177

Query: 119 IGAAVFGVDVDQNTLDTPALNITRKALEPTLKSIMTFFL--AGTFPRLIKWLD------M 170
           I + +F    D    D   LN+  K L   +K + + ++     F  +I +        +
Sbjct: 178 ICSIIFHKRFDYK--DQQFLNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 234

Query: 171 MNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLX 230
            N    ++  ++ VK+  E+      Q DFID C  ++  +   +  + + I    E L 
Sbjct: 235 KNVAFMKSYILEKVKEHQESMDMNNPQ-DFID-CFLMKMEKEKHNQPSEFTI----ESLE 288

Query: 231 XXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKY 290
                      +TT+  + + LL L  +P V  K+  EI+ V    +     +D     Y
Sbjct: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRSHMPY 347

Query: 291 LEMVVNETMRKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKS 348
            + VV+E  R     P  L   +     ++   N  I K T  ++ + ++  D + +P  
Sbjct: 348 TDAVVHEVQRYIDLLPTSLPHAVTC---DIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404

Query: 349 DAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           + FDP  F  E  N      F+PF  G R+C+G   A ++L   L  +L+ + L
Sbjct: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458


>AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 95/414 (22%), Positives = 168/414 (40%), Gaps = 38/414 (9%)

Query: 7   FTL--GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKIL 63
           FTL  G +P ++L     ++  L    + F  RGI  L+E+      I+F +   +WK +
Sbjct: 65  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEI 123

Query: 64  RQKLSPAFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEEMPFNAIYKYTTGS 118
           R+     FS + L+    G +RS  D V+      +E     +     P   +       
Sbjct: 124 RR-----FSLMTLRNFGMG-KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177

Query: 119 IGAAVFGVDVDQNTLDTPALNITRKALEPTLKSIMTFFL--AGTFPRLIKWLD------M 170
           I + +F    D    D   LN+  K L   +K + + ++     F  +I +        +
Sbjct: 178 ICSIIFHKRFDYK--DQQFLNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 234

Query: 171 MNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLX 230
            N    ++  ++ VK+  E+      Q DFID C  ++  +   +  + + I    E L 
Sbjct: 235 KNVAFMKSYILEKVKEHQESMDMNNPQ-DFID-CFLMKMEKEKHNQPSEFTI----ESLE 288

Query: 231 XXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKY 290
                      +TT+  + + LL L  +P V  K+  EI+ V    +     +D     Y
Sbjct: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRSHMPY 347

Query: 291 LEMVVNETMRKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKS 348
            + VV+E  R     P  L   +     ++   N  I K T  ++ + ++  D + +P  
Sbjct: 348 TDAVVHEVQRYIDLLPTSLPHAVTC---DIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404

Query: 349 DAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           + FDP  F  E  N      F+PF  G R+C+G   A ++L   L  +L+ + L
Sbjct: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458


>AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 95/414 (22%), Positives = 168/414 (40%), Gaps = 38/414 (9%)

Query: 7   FTL--GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKIL 63
           FTL  G +P ++L     ++  L    + F  RGI  L+E+      I+F +   +WK +
Sbjct: 65  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEI 123

Query: 64  RQKLSPAFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEEMPFNAIYKYTTGS 118
           R+     FS + L+    G +RS  D V+      +E     +     P   +       
Sbjct: 124 RR-----FSLMTLRNFGMG-KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177

Query: 119 IGAAVFGVDVDQNTLDTPALNITRKALEPTLKSIMTFFL--AGTFPRLIKWLD------M 170
           I + +F    D    D   LN+  K L   +K + + ++     F  +I +        +
Sbjct: 178 ICSIIFHKRFDYK--DQQFLNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 234

Query: 171 MNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLX 230
            N    ++  ++ VK+  E+      Q DFID C  ++  +   +  + + I    E L 
Sbjct: 235 KNVAFMKSYILEKVKEHQESMDMNNPQ-DFID-CFLMKMEKEKHNQPSEFTI----ESLE 288

Query: 231 XXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKY 290
                      +TT+  + + LL L  +P V  K+  EI+ V    +     +D     Y
Sbjct: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRSHMPY 347

Query: 291 LEMVVNETMRKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKS 348
            + VV+E  R     P  L   +     ++   N  I K T  ++ + ++  D + +P  
Sbjct: 348 TDAVVHEVQRYIDLLPTSLPHAVTC---DIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404

Query: 349 DAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           + FDP  F  E  N      F+PF  G R+C+G   A ++L   L  +L+ + L
Sbjct: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458


>AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score = 73.7 bits (173), Expect = 1e-12
 Identities = 95/414 (22%), Positives = 168/414 (40%), Gaps = 38/414 (9%)

Query: 7   FTL--GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKIL 63
           FTL  G +P ++L     ++  L    + F  RGI  L+E+      I+F +   +WK +
Sbjct: 65  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEI 123

Query: 64  RQKLSPAFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEEMPFNAIYKYTTGS 118
           R+     FS + L+    G +RS  D V+      +E     +     P   +       
Sbjct: 124 RR-----FSLMTLRNFGMG-KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177

Query: 119 IGAAVFGVDVDQNTLDTPALNITRKALEPTLKSIMTFFL--AGTFPRLIKWLD------M 170
           I + +F    D    D   LN+  K L   +K + + ++     F  +I +        +
Sbjct: 178 ICSIIFHKRFDYK--DQQFLNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 234

Query: 171 MNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLX 230
            N    ++  ++ VK+  E+      Q DFID C  ++  +   +  + + I    E L 
Sbjct: 235 KNVAFMKSYILEKVKEHQESMDMNNPQ-DFID-CFLMKMEKEKHNQPSEFTI----ESLE 288

Query: 231 XXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKY 290
                      +TT+  + + LL L  +P V  K+  EI+ V    +     +D     Y
Sbjct: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRSHMPY 347

Query: 291 LEMVVNETMRKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKS 348
            + VV+E  R     P  L   +     ++   N  I K T  ++ + ++  D + +P  
Sbjct: 348 TDAVVHEVQRYIDLLPTSLPHAVTC---DIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404

Query: 349 DAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           + FDP  F  E  N      F+PF  G R+C+G   A ++L   L  +L+ + L
Sbjct: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458


>M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.
          Length = 485

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 95/414 (22%), Positives = 168/414 (40%), Gaps = 38/414 (9%)

Query: 7   FTL--GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKIL 63
           FTL  G +P ++L     ++  L    + F  RGI  L+E+      I+F +   +WK +
Sbjct: 60  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEI 118

Query: 64  RQKLSPAFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEEMPFNAIYKYTTGS 118
           R+     FS + L+    G +RS  D V+      +E     +     P   +       
Sbjct: 119 RR-----FSLMTLRNFGMG-KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 172

Query: 119 IGAAVFGVDVDQNTLDTPALNITRKALEPTLKSIMTFFL--AGTFPRLIKWLD------M 170
           I + +F    D    D   LN+  K L   +K + + ++     F  +I +        +
Sbjct: 173 ICSIIFHKRFDYK--DQQFLNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 229

Query: 171 MNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLX 230
            N    ++  ++ VK+  E+      Q DFID C  ++  +   +  + + I    E L 
Sbjct: 230 KNVAFMKSYILEKVKEHQESMDMNNPQ-DFID-CFLMKMEKEKHNQPSEFTI----ESLE 283

Query: 231 XXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKY 290
                      +TT+  + + LL L  +P V  K+  EI+ V    +     +D     Y
Sbjct: 284 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRSHMPY 342

Query: 291 LEMVVNETMRKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKS 348
            + VV+E  R     P  L   +     ++   N  I K T  ++ + ++  D + +P  
Sbjct: 343 TDAVVHEVQRCIDLLPTSLPHAVTC---DIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 399

Query: 349 DAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           + FDP  F  E  N      F+PF  G R+C+G   A ++L   L  +L+ + L
Sbjct: 400 EMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 453


>M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.
          Length = 485

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 95/414 (22%), Positives = 168/414 (40%), Gaps = 38/414 (9%)

Query: 7   FTL--GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKIL 63
           FTL  G +P ++L     ++  L    + F  RGI  L+E+      I+F +   +WK +
Sbjct: 60  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEI 118

Query: 64  RQKLSPAFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEEMPFNAIYKYTTGS 118
           R+     FS + L+    G +RS  D V+      +E     +     P   +       
Sbjct: 119 RR-----FSLMTLRNFGMG-KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 172

Query: 119 IGAAVFGVDVDQNTLDTPALNITRKALEPTLKSIMTFFL--AGTFPRLIKWLD------M 170
           I + +F    D    D   LN+  K L   +K + + ++     F  +I +        +
Sbjct: 173 ICSIIFHKRFDYK--DQQFLNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 229

Query: 171 MNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLX 230
            N    ++  ++ VK+  E+      Q DFID C  ++  +   +  + + I    E L 
Sbjct: 230 KNVAFMKSYILEKVKEHQESMDMNNPQ-DFID-CFLMKMEKEKHNQPSEFTI----ESLE 283

Query: 231 XXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKY 290
                      +TT+  + + LL L  +P V  K+  EI+ V    +     +D     Y
Sbjct: 284 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRSHMPY 342

Query: 291 LEMVVNETMRKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKS 348
            + VV+E  R     P  L   +     ++   N  I K T  ++ + ++  D + +P  
Sbjct: 343 TDAVVHEVQRCIDLLPTSLPHAVTC---DIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 399

Query: 349 DAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           + FDP  F  E  N      F+PF  G R+C+G   A ++L   L  +L+ + L
Sbjct: 400 EMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 453


>L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxylase
           protein.
          Length = 217

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 48/179 (26%), Positives = 77/179 (43%), Gaps = 4/179 (2%)

Query: 225 TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFED 284
           T E L            +TT+  + + LL L  +P V  K+  EI+ V    +     +D
Sbjct: 10  TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQD 68

Query: 285 MDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRDER 343
                Y + VV+E  R    I   L    T +      N  I K T  +  + ++  D +
Sbjct: 69  RGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF--RNYLIPKGTTILTSLTSVLHDNK 126

Query: 344 FYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
            +P  + FDP+ F  E  N      F+PF  G R+C+G   AR++L   L ++L+ + L
Sbjct: 127 EFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 185


>J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrome
           P450IIE1 (ethanol-inducible) gene, complete cds. ).
          Length = 493

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 59/184 (32%), Positives = 86/184 (46%), Gaps = 15/184 (8%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + + LL L   P + +KLH EID V    +     +D  +  Y++ VV+E  R 
Sbjct: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVHEIQRF 360

Query: 302 YPPI-GLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
              +   L    T++T        I K T+ VVP L    D   Y   +  DP++F PE+
Sbjct: 361 ITLVPSNLPHEATRDTIF--RGYLIPKGTV-VVPTL----DSVLYDNQEFPDPEKFKPEH 413

Query: 361 F-NEINKFS----FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
           F NE  KF     F PF  G RVC G   AR++L   L  +L+ + L P    P   + S
Sbjct: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL-VDPKDIDLS 472

Query: 416 PFAV 419
           P  +
Sbjct: 473 PIHI 476


>J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrome
           P-450j mRNA, complete cds. ).
          Length = 493

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 59/184 (32%), Positives = 86/184 (46%), Gaps = 15/184 (8%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + + LL L   P + +KLH EID V    +     +D  +  Y++ VV+E  R 
Sbjct: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVHEIQRF 360

Query: 302 YPPI-GLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
              +   L    T++T        I K T+ VVP L    D   Y   +  DP++F PE+
Sbjct: 361 ITLVPSNLPHEATRDTIF--RGYLIPKGTV-VVPTL----DSVLYDNQEFPDPEKFKPEH 413

Query: 361 F-NEINKFS----FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
           F NE  KF     F PF  G RVC G   AR++L   L  +L+ + L P    P   + S
Sbjct: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL-VDPKDIDLS 472

Query: 416 PFAV 419
           P  +
Sbjct: 473 PIHI 476


>DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 59/184 (32%), Positives = 86/184 (46%), Gaps = 15/184 (8%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + + LL L   P + +KLH EID V    +     +D  +  Y++ VV+E  R 
Sbjct: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVHEIQRF 360

Query: 302 YPPI-GLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
              +   L    T++T        I K T+ VVP L    D   Y   +  DP++F PE+
Sbjct: 361 ITLVPSNLPHEATRDTIF--RGYLIPKGTV-VVPTL----DSVLYDNQEFPDPEKFKPEH 413

Query: 361 F-NEINKFS----FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
           F NE  KF     F PF  G RVC G   AR++L   L  +L+ + L P    P   + S
Sbjct: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL-VDPKDIDLS 472

Query: 416 PFAV 419
           P  +
Sbjct: 473 PIHI 476


>DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1
           protein.
          Length = 493

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 59/184 (32%), Positives = 86/184 (46%), Gaps = 15/184 (8%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + + LL L   P + +KLH EID V    +     +D  +  Y++ VV+E  R 
Sbjct: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVHEIQRF 360

Query: 302 YPPI-GLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
              +   L    T++T        I K T+ VVP L    D   Y   +  DP++F PE+
Sbjct: 361 ITLVPSNLPHEATRDTIF--RGYLIPKGTV-VVPTL----DSVLYDNQEFPDPEKFKPEH 413

Query: 361 F-NEINKFS----FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
           F NE  KF     F PF  G RVC G   AR++L   L  +L+ + L P    P   + S
Sbjct: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL-VDPKDIDLS 472

Query: 416 PFAV 419
           P  +
Sbjct: 473 PIHI 476


>AL358613-3|CAH72804.1|  428|Homo sapiens cytochrome P450, family
           26, subfamily A, polypeptide 1 protein.
          Length = 428

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 46/155 (29%), Positives = 78/155 (50%), Gaps = 10/155 (6%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEID------EVFQDGKKTLNFEDMDKFKYLEMVV 295
           +TTA+     +  L   P VL+K+  E+       +  QD K  L+ E +++ KY+  V+
Sbjct: 234 ETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNK--LDMEILEQLKYIGCVI 291

Query: 296 NETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQR 355
            ET+R  PP+    R+  K   L  N  +I K    +  +   H     +   + F+P R
Sbjct: 292 KETLRLNPPVPGGFRVALKTFEL--NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDR 349

Query: 356 FAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLR 390
           F   +  + ++FSF+PFG G R C+G +FA++ L+
Sbjct: 350 FMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLK 384


>AL358613-2|CAH72803.1|  497|Homo sapiens cytochrome P450, family
           26, subfamily A, polypeptide 1 protein.
          Length = 497

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 46/155 (29%), Positives = 78/155 (50%), Gaps = 10/155 (6%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEID------EVFQDGKKTLNFEDMDKFKYLEMVV 295
           +TTA+     +  L   P VL+K+  E+       +  QD K  L+ E +++ KY+  V+
Sbjct: 303 ETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNK--LDMEILEQLKYIGCVI 360

Query: 296 NETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQR 355
            ET+R  PP+    R+  K   L  N  +I K    +  +   H     +   + F+P R
Sbjct: 361 KETLRLNPPVPGGFRVALKTFEL--NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDR 418

Query: 356 FAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLR 390
           F   +  + ++FSF+PFG G R C+G +FA++ L+
Sbjct: 419 FMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLK 453


>AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 59/184 (32%), Positives = 86/184 (46%), Gaps = 15/184 (8%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + + LL L   P + +KLH EID V    +     +D  +  Y++ VV+E  R 
Sbjct: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVHEIQRF 360

Query: 302 YPPI-GLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
              +   L    T++T        I K T+ VVP L    D   Y   +  DP++F PE+
Sbjct: 361 ITLVPSNLPHEATRDTIF--RGYLIPKGTV-VVPTL----DSVLYDNQEFPDPEKFKPEH 413

Query: 361 F-NEINKFS----FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
           F NE  KF     F PF  G RVC G   AR++L   L  +L+ + L P    P   + S
Sbjct: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL-VDPKDIDLS 472

Query: 416 PFAV 419
           P  +
Sbjct: 473 PIHI 476


>AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1
           protein.
          Length = 493

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 59/184 (32%), Positives = 86/184 (46%), Gaps = 15/184 (8%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + + LL L   P + +KLH EID V    +     +D  +  Y++ VV+E  R 
Sbjct: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVHEIQRF 360

Query: 302 YPPI-GLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
              +   L    T++T        I K T+ VVP L    D   Y   +  DP++F PE+
Sbjct: 361 ITLVPSNLPHEATRDTIF--RGYLIPKGTV-VVPTL----DSVLYDNQEFPDPEKFKPEH 413

Query: 361 F-NEINKFS----FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
           F NE  KF     F PF  G RVC G   AR++L   L  +L+ + L P    P   + S
Sbjct: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL-VDPKDIDLS 472

Query: 416 PFAV 419
           P  +
Sbjct: 473 PIHI 476


>AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1
           protein.
          Length = 462

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 59/184 (32%), Positives = 86/184 (46%), Gaps = 15/184 (8%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + + LL L   P + +KLH EID V    +     +D  +  Y++ VV+E  R 
Sbjct: 271 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVHEIQRF 329

Query: 302 YPPI-GLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
              +   L    T++T        I K T+ VVP L    D   Y   +  DP++F PE+
Sbjct: 330 ITLVPSNLPHEATRDTIF--RGYLIPKGTV-VVPTL----DSVLYDNQEFPDPEKFKPEH 382

Query: 361 F-NEINKFS----FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
           F NE  KF     F PF  G RVC G   AR++L   L  +L+ + L P    P   + S
Sbjct: 383 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL-VDPKDIDLS 441

Query: 416 PFAV 419
           P  +
Sbjct: 442 PIHI 445


>AF005418-1|AAB88881.1|  497|Homo sapiens retinoic acid hydroxylase
           protein.
          Length = 497

 Score = 73.3 bits (172), Expect = 1e-12
 Identities = 46/155 (29%), Positives = 78/155 (50%), Gaps = 10/155 (6%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEID------EVFQDGKKTLNFEDMDKFKYLEMVV 295
           +TTA+     +  L   P VL+K+  E+       +  QD K  L+ E +++ KY+  V+
Sbjct: 303 ETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNK--LDMEILEQLKYIGCVI 360

Query: 296 NETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQR 355
            ET+R  PP+    R+  K   L  N  +I K    +  +   H     +   + F+P R
Sbjct: 361 KETLRLNPPVPGGFRVALKTFEL--NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDR 418

Query: 356 FAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLR 390
           F   +  + ++FSF+PFG G R C+G +FA++ L+
Sbjct: 419 FMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLK 453


>X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C
           protein.
          Length = 356

 Score = 72.9 bits (171), Expect = 2e-12
 Identities = 48/179 (26%), Positives = 78/179 (43%), Gaps = 4/179 (2%)

Query: 225 TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFED 284
           T E L            +TT+  + + LL L  +P V  K+  EI+ V    +     +D
Sbjct: 149 TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC-MQD 207

Query: 285 MDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRDER 343
                Y + VV+E  R    I   L    T   ++   N  I K T  +  + ++  D +
Sbjct: 208 RGHMPYTDAVVHEVQRYIDLIPTSLPHAVT--CDIKFRNYLIPKGTTILTSLTSVLHDNK 265

Query: 344 FYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
            +P  + FDP+ F  E  N      F+PF  G R+C+G   AR++L   L ++L+ + L
Sbjct: 266 EFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 324


>BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score = 72.9 bits (171), Expect = 2e-12
 Identities = 59/184 (32%), Positives = 85/184 (46%), Gaps = 15/184 (8%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + + LL L   P + +KLH EID V    +     +D  +  Y++ VV E  R 
Sbjct: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVREIQRF 360

Query: 302 YPPI-GLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
              +   L    T++T        I K T+ VVP L    D   Y   +  DP++F PE+
Sbjct: 361 ITLVPSNLPHEATRDTIF--RGYLIPKGTV-VVPTL----DSVLYDNQEFPDPEKFKPEH 413

Query: 361 F-NEINKFS----FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
           F NE  KF     F PF  G RVC G   AR++L   L  +L+ + L P    P   + S
Sbjct: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL-VDPKDIDLS 472

Query: 416 PFAV 419
           P  +
Sbjct: 473 PIHI 476


>Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 6/167 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT+  + + LL L  +P V  K+  EID V    +     +D     Y + VV+E  R 
Sbjct: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDAVVHEIQRY 358

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P G+   + T +T     N  I K T  +  + ++  D++ +P  + FDP  F  +
Sbjct: 359 SDLVPTGVPHAVTT-DTKF--RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDK 415

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQD 406
           N N      F+PF  G R+C G   AR++L   L  +L+ + L   D
Sbjct: 416 NGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD 462


>M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 93/421 (22%), Positives = 171/421 (40%), Gaps = 29/421 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKILRQKLS 68
           G +P ++L     ++  L    + F  RG   ++EK      ILF +   RWK +R+   
Sbjct: 70  GLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNG-KRWKEIRRFCL 128

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
               +  +  +++ + ++  AR  VE +  + N    +  P   +       I + +F  
Sbjct: 129 MTLRNFGMGKRSIEDRVQEEARCLVEELRKT-NASPCD--PTFILGCAPCNVICSVIFHD 185

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLD------MMNFDNYETS 179
             D    D   LN+  K  E   + S     +   FP LI +L         NF   ++ 
Sbjct: 186 RFDYK--DQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +K+  E+      + DFID C  ++  +   +  + + +    E L          
Sbjct: 244 VLERIKEHQESLDMNSAR-DFID-CFLIKMEQEKHNQQSEFTV----ESLIATVTDMFGA 297

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT+  + + LL L   P V  K+  EI+ V    +     +D     Y + VV+E  
Sbjct: 298 GTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQ 356

Query: 300 RKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA 357
           R     P  L   +     ++   N  I K T  +  + ++  +++ +P  + FDP  F 
Sbjct: 357 RYIDLLPTNLPHAVTC---DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPF 417
            ++ N      F+PF  G R+C+G   AR++L   L  +L+ + L  Q   P   + +P 
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQ-VDPKDIDITPI 472

Query: 418 A 418
           A
Sbjct: 473 A 473


>M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.
          Length = 462

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 6/167 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT+  + + LL L  +P V  K+  EID V    +     +D     Y + VV+E  R 
Sbjct: 272 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDAVVHEIQRY 330

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P G+   + T +T     N  I K T  +  + ++  D++ +P  + FDP  F  +
Sbjct: 331 SDLVPTGVPHAVTT-DTKF--RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDK 387

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQD 406
           N N      F+PF  G R+C G   AR++L   L  +L+ + L   D
Sbjct: 388 NGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD 434


>M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrome
           P-450 1 functional form mRNA, complete cds. ).
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 6/167 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT+  + + LL L  +P V  K+  EID V    +     +D     Y + VV+E  R 
Sbjct: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDAVVHEIQRY 358

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P G+   + T +T     N  I K T  +  + ++  D++ +P  + FDP  F  +
Sbjct: 359 SDLVPTGVPHAVTT-DTKF--RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDK 415

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQD 406
           N N      F+PF  G R+C G   AR++L   L  +L+ + L   D
Sbjct: 416 NGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD 462


>D13752-1|BAA02899.1|  503|Homo sapiens steroid 18-hydroxylase
           protein.
          Length = 503

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 89/372 (23%), Positives = 166/372 (44%), Gaps = 29/372 (7%)

Query: 52  LFIDDLPRWKILRQKLSP-AFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEE 105
           +F+ + P W+  R +L+P   S   ++     ++  ARDF +      ++N+     L+ 
Sbjct: 129 VFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDV 188

Query: 106 MPFNAIYKYTTGSIGAAVFG--VDVDQNTLDTPALNITRKALEPTLKSIMTFFLAGTFPR 163
            P  +I+ YT  +   A+FG  + +  ++  + +LN    ALE   KS +        PR
Sbjct: 189 QP--SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH-ALEVMFKSTVQLMF---MPR 242

Query: 164 -LIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEI 222
            L +W+    +  +  ++ D + +  +N    +K Y  +          ++ +L+   E+
Sbjct: 243 SLSRWISPKVWKEHFEAW-DCIFQYGDN--CIQKIYQELAFNRPQHYTGIVAELLLKAEL 299

Query: 223 VPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNF 282
             + E +            DTTA  +  TL EL+ NP V + L  E         +    
Sbjct: 300 --SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ- 356

Query: 283 EDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRD 341
           +   +   L   + ET+R YP +GL L+R+ + +  L   N  I   T+  V + +L R+
Sbjct: 357 KATTELPLLRAALKETLRLYP-VGLFLERVVSSDLVL--QNYHIPAGTLVQVFLYSLGRN 413

Query: 342 ERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY- 400
              +P+ + ++PQR+     +  N F  +PFG G R C+G + A  ++   L  +L+ + 
Sbjct: 414 AALFPRPERYNPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL 472

Query: 401 --TLVPQDYKPV 410
             TL  +D K V
Sbjct: 473 VETLTQEDIKMV 484


>BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 93/421 (22%), Positives = 171/421 (40%), Gaps = 29/421 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKILRQKLS 68
           G +P ++L     ++  L    + F  RG   ++EK      ILF +   RWK +R+   
Sbjct: 70  GLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNG-KRWKEIRRFCL 128

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
               +  +  +++ + ++  AR  VE +  + N    +  P   +       I + +F  
Sbjct: 129 MTLRNFGMGKRSIEDRVQEEARCLVEELRKT-NASPCD--PTFILGCAPCNVICSVIFHD 185

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLD------MMNFDNYETS 179
             D    D   LN+  K  E   + S     +   FP LI +L         NF   ++ 
Sbjct: 186 RFDYK--DQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +K+  E+      + DFID C  ++  +   +  + + +    E L          
Sbjct: 244 VLERIKEHQESLDMNSAR-DFID-CFLIKMEQEKHNQQSEFTV----ESLIATVTDMFGA 297

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT+  + + LL L   P V  K+  EI+ V    +     +D     Y + VV+E  
Sbjct: 298 GTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQ 356

Query: 300 RKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA 357
           R     P  L   +     ++   N  I K T  +  + ++  +++ +P  + FDP  F 
Sbjct: 357 RYIDLLPTNLPHAVTC---DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPF 417
            ++ N      F+PF  G R+C+G   AR++L   L  +L+ + L  Q   P   + +P 
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQ-VDPKDIDITPI 472

Query: 418 A 418
           A
Sbjct: 473 A 473


>BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 93/421 (22%), Positives = 171/421 (40%), Gaps = 29/421 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKILRQKLS 68
           G +P ++L     ++  L    + F  RG   ++EK      ILF +   RWK +R+   
Sbjct: 70  GLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNG-KRWKEIRRFCL 128

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
               +  +  +++ + ++  AR  VE +  + N    +  P   +       I + +F  
Sbjct: 129 MTLRNFGMGKRSIEDRVQEEARCLVEELRKT-NASPCD--PTFILGCAPCNVICSVIFHD 185

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLD------MMNFDNYETS 179
             D    D   LN+  K  E   + S     +   FP LI +L         NF   ++ 
Sbjct: 186 RFDYK--DQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +K+  E+      + DFID C  ++  +   +  + + +    E L          
Sbjct: 244 VLERIKEHQESLDMNSAR-DFID-CFLIKMEQEKHNQQSEFTV----ESLIATVTDMFGA 297

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT+  + + LL L   P V  K+  EI+ V    +     +D     Y + VV+E  
Sbjct: 298 GTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQ 356

Query: 300 RKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA 357
           R     P  L   +     ++   N  I K T  +  + ++  +++ +P  + FDP  F 
Sbjct: 357 RYIDLLPTNLPHAVTC---DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPF 417
            ++ N      F+PF  G R+C+G   AR++L   L  +L+ + L  Q   P   + +P 
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQ-VDPKDIDITPI 472

Query: 418 A 418
           A
Sbjct: 473 A 473


>BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 93/421 (22%), Positives = 171/421 (40%), Gaps = 29/421 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKILRQKLS 68
           G +P ++L     ++  L    + F  RG   ++EK      ILF +   RWK +R+   
Sbjct: 70  GLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNG-KRWKEIRRFCL 128

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
               +  +  +++ + ++  AR  VE +  + N    +  P   +       I + +F  
Sbjct: 129 MTLRNFGMGKRSIEDRVQEEARCLVEELRKT-NASPCD--PTFILGCAPCNVICSVIFHD 185

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLD------MMNFDNYETS 179
             D    D   LN+  K  E   + S     +   FP LI +L         NF   ++ 
Sbjct: 186 RFDYK--DQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +K+  E+      + DFID C  ++  +   +  + + +    E L          
Sbjct: 244 VLERIKEHQESLDMNSAR-DFID-CFLIKMEQEKHNQQSEFTV----ESLIATVTDMFGA 297

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT+  + + LL L   P V  K+  EI+ V    +     +D     Y + VV+E  
Sbjct: 298 GTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQ 356

Query: 300 RKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA 357
           R     P  L   +     ++   N  I K T  +  + ++  +++ +P  + FDP  F 
Sbjct: 357 RYIDLLPTNLPHAVTC---DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPF 417
            ++ N      F+PF  G R+C+G   AR++L   L  +L+ + L  Q   P   + +P 
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQ-VDPKDIDITPI 472

Query: 418 A 418
           A
Sbjct: 473 A 473


>BC041158-1|AAH41158.1|  455|Homo sapiens CYP4A11 protein protein.
          Length = 455

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 38/136 (27%), Positives = 70/136 (51%), Gaps = 4/136 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNR 377
              +  +FLPF  G+R
Sbjct: 442 Q--HSHAFLPFSGGSR 455


>BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 6/167 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT+  + + LL L  +P V  K+  EID V    +     +D     Y + VV+E  R 
Sbjct: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDAVVHEIQRY 358

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P G+   + T +T     N  I K T  +  + ++  D++ +P  + FDP  F  +
Sbjct: 359 SDLVPTGVPHAVTT-DTKF--RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDK 415

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQD 406
           N N      F+PF  G R+C G   AR++L   L  +L+ + L   D
Sbjct: 416 NGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD 462


>AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 6/167 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT+  + + LL L  +P V  K+  EID V    +     +D     Y + VV+E  R 
Sbjct: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDAVVHEIQRY 358

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P G+   + T +T     N  I K T  +  + ++  D++ +P  + FDP  F  +
Sbjct: 359 SDLVPTGVPHAVTT-DTKF--RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDK 415

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQD 406
           N N      F+PF  G R+C G   AR++L   L  +L+ + L   D
Sbjct: 416 NGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD 462


>AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13
           variant 5 protein.
          Length = 494

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 52/173 (30%), Positives = 82/173 (47%), Gaps = 9/173 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+GL  R+  K+T     +  + K T  V P+L ++ RD RF+     F+PQ F  
Sbjct: 363 GDMLPMGLAHRV-NKDTKF--RDFFLPKGT-EVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPV 410
           +        +F+PF  G R C G   AR++L      +++ +    PQ  K +
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDI 471


>AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13
           variant 3 protein.
          Length = 494

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 52/173 (30%), Positives = 82/173 (47%), Gaps = 9/173 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+GL  R+  K+T     +  + K T  V P+L ++ RD RF+     F+PQ F  
Sbjct: 363 GDMLPMGLAHRV-NKDTKF--RDFFLPKGT-EVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPV 410
           +        +F+PF  G R C G   AR++L      +++ +    PQ  K +
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDI 471


>AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13
           variant 2 protein.
          Length = 494

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 52/173 (30%), Positives = 82/173 (47%), Gaps = 9/173 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+GL  R+  K+T     +  + K T  V P+L ++ RD RF+     F+PQ F  
Sbjct: 363 GDMLPMGLAHRV-NKDTKF--RDFFLPKGT-EVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPV 410
           +        +F+PF  G R C G   AR++L      +++ +    PQ  K +
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDI 471


>AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13
           variant 1 protein.
          Length = 494

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 52/173 (30%), Positives = 82/173 (47%), Gaps = 9/173 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+GL  R+  K+T     +  + K T  V P+L ++ RD RF+     F+PQ F  
Sbjct: 363 GDMLPMGLAHRV-NKDTKF--RDFFLPKGT-EVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPV 410
           +        +F+PF  G R C G   AR++L      +++ +    PQ  K +
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDI 471


>AL731892-4|CAH72779.1|  455|Homo sapiens cytochrome P450, family 4,
           subfamily A, polypeptide 11 protein.
          Length = 455

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 38/136 (27%), Positives = 70/136 (51%), Gaps = 4/136 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHSLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNR 377
              +  +FLPF  G+R
Sbjct: 442 Q--HSHAFLPFSGGSR 455


>AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 93/421 (22%), Positives = 171/421 (40%), Gaps = 29/421 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKILRQKLS 68
           G +P ++L     ++  L    + F  RG   ++EK      ILF +   RWK +R+   
Sbjct: 70  GLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNG-KRWKEIRRFCL 128

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
               +  +  +++ + ++  AR  VE +  + N    +  P   +       I + +F  
Sbjct: 129 MTLRNFGMGKRSIEDRVQEEARCLVEELRKT-NASPCD--PTFILGCAPCNVICSVIFHD 185

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLD------MMNFDNYETS 179
             D    D   LN+  K  E   + S     +   FP LI +L         NF   ++ 
Sbjct: 186 RFDYK--DQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +K+  E+      + DFID C  ++  +   +  + + +    E L          
Sbjct: 244 VLERIKEHQESLDMNSAR-DFID-CFLIKMEQEKHNQQSEFTV----ESLIATVTDMFGA 297

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT+  + + LL L   P V  K+  EI+ V    +     +D     Y + VV+E  
Sbjct: 298 GTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQ 356

Query: 300 RKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA 357
           R     P  L   +     ++   N  I K T  +  + ++  +++ +P  + FDP  F 
Sbjct: 357 RYIDLLPTNLPHAVTC---DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPF 417
            ++ N      F+PF  G R+C+G   AR++L   L  +L+ + L  Q   P   + +P 
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQ-VDPKDIDITPI 472

Query: 418 A 418
           A
Sbjct: 473 A 473


>AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 6/167 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT+  + + LL L  +P V  K+  EID V    +     +D     Y + VV+E  R 
Sbjct: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDAVVHEIQRY 358

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P G+   + T +T     N  I K T  +  + ++  D++ +P  + FDP  F  +
Sbjct: 359 SDLVPTGVPHAVTT-DTKF--RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDK 415

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQD 406
           N N      F+PF  G R+C G   AR++L   L  +L+ + L   D
Sbjct: 416 NGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD 462


>AL135960-11|CAI19738.1|  455|Homo sapiens cytochrome P450, family
           4, subfamily A, polypeptide 22 protein.
          Length = 455

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 38/136 (27%), Positives = 70/136 (51%), Gaps = 4/136 (2%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           DTTA+ + + L  L+++P   ++   EI  +  DG  ++ +  +D+  Y  M + E +R 
Sbjct: 324 DTTASGISWILYALATHPKHQERCREEIHGLLGDGA-SITWNHLDQMPYTTMCIKEALRL 382

Query: 302 YPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENF 361
           YPP+  + R  +     P     + K  + ++ +  LH + + +P  + FDP RFAP + 
Sbjct: 383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSA 441

Query: 362 NEINKFSFLPFGEGNR 377
              +  +FLPF  G+R
Sbjct: 442 Q--HSHAFLPFSGGSR 455


>AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13
           protein.
          Length = 494

 Score = 72.5 bits (170), Expect = 3e-12
 Identities = 52/173 (30%), Positives = 82/173 (47%), Gaps = 9/173 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+GL  R+  K+T     +  + K T  V P+L ++ RD RF+     F+PQ F  
Sbjct: 363 GDMLPMGLAHRV-NKDTKF--RDFFLPKGT-EVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPV 410
           +        +F+PF  G R C G   AR++L      +++ +    PQ  K +
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDI 471


>M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.
          Length = 383

 Score = 72.1 bits (169), Expect = 3e-12
 Identities = 60/249 (24%), Positives = 106/249 (42%), Gaps = 17/249 (6%)

Query: 156 FLAGTFPRLIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRD 215
           +  GT  +L+K +  M     ++  ++ VK+  E+      Q DFID C  ++  +   +
Sbjct: 118 YFPGTHNKLLKNVAFM-----KSYILEKVKEHQESMDMNNPQ-DFID-CFLMKMEKEKHN 170

Query: 216 LVTGYEIVPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQD 275
             + + I    E L            +TT+  + + LL L  +P V  K+  EI+ V   
Sbjct: 171 QPSEFTI----ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGR 226

Query: 276 GKKTLNFEDMDKFKYLEMVVNETMRKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVV 333
            +     +D     Y + VV+E  R     P  L   +     ++   N  I K T  ++
Sbjct: 227 NRSPC-MQDRSHMPYTDAVVHEVQRCIDLLPTSLPHAVTC---DIKFRNYLIPKGTTILI 282

Query: 334 PVLALHRDERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGL 393
            + ++  D + +P  + FDP  F  E  N      F+PF  G R+C+G   A ++L   L
Sbjct: 283 SLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFL 342

Query: 394 AWLLRKYTL 402
             +L+ + L
Sbjct: 343 TSILQNFNL 351


>L36085-1|AAC01761.1|  441|Homo sapiens thromboxane A2 synthase
           protein.
          Length = 441

 Score = 72.1 bits (169), Expect = 3e-12
 Identities = 79/330 (23%), Positives = 147/330 (44%), Gaps = 35/330 (10%)

Query: 7   FTLGRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQK 66
           + LGRR  I++ +   I+ VL  +F +F +R     E +++ADS+LF+ D  RW+ +R  
Sbjct: 81  YYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD-KRWEEVRGA 139

Query: 67  LSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
           L  AFS  ++  M   I ++    +  ++      D  ++       YTT  + +  FG 
Sbjct: 140 LMSAFSPEKVNEMVPLISQACDLLLAHLKRYAESGDAFDIQ-RCYCNYTTDVVASVRFGT 198

Query: 127 DVDQ-NTLDTPALNITRKALEPTL-KSIMTFFLA--GTFPRLIKWLDMMNFDNYETSFID 182
            VD     + P +   ++  E  + + I+   L+       L + L   N D     F  
Sbjct: 199 PVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNK 258

Query: 183 AVKKVL---ENRRAGEKQYDFIDVCLE---------LQNHEVLRDLV--TGYEIVP---- 224
            ++ V+   + + A E++ DF+ + L+         +Q+ +++RD+   TG +  P    
Sbjct: 259 LIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQH 318

Query: 225 ---------TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQD 275
                    T + +            +   N + F    L++NP   +KL  E+D VF++
Sbjct: 319 QPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKE 377

Query: 276 GKKTLNFEDMDK-FKYLEMVVNETMRKYPP 304
                 F  +++   YL+MV+ ET+R YPP
Sbjct: 378 KHMAPEFCSLEEGLPYLDMVIAETLRMYPP 407


>BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score = 72.1 bits (169), Expect = 3e-12
 Identities = 59/184 (32%), Positives = 85/184 (46%), Gaps = 15/184 (8%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRK 301
           +TT+  + + LL L   P + +KLH EID V    +     +D  +  Y++ VV+E  R 
Sbjct: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVHEIQRF 360

Query: 302 YPPI-GLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPEN 360
              +   L    T++T        I K T+ VVP L    D   Y   +  DP++F PE+
Sbjct: 361 ITLVPSNLPHEATRDTIF--RGYLIPKGTV-VVPTL----DSVLYDNQEFPDPEKFKPEH 413

Query: 361 F-NEINKFS----FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERS 415
           F NE  KF     F PF  G RVC G   AR +L   L  +L+ + L P    P   + S
Sbjct: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARTELFLLLCAILQHFNLKPL-VDPKDIDLS 472

Query: 416 PFAV 419
           P  +
Sbjct: 473 PIHI 476


>X54741-1|CAA38539.1|  503|Homo sapiens aldosterone  synthase
           (P-450aldo) protein.
          Length = 503

 Score = 71.7 bits (168), Expect = 5e-12
 Identities = 89/372 (23%), Positives = 166/372 (44%), Gaps = 29/372 (7%)

Query: 52  LFIDDLPRWKILRQKLSP-AFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEE 105
           +F+ + P W+  R +L+P   S   ++     ++  ARDF +      ++N+     L+ 
Sbjct: 129 VFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDV 188

Query: 106 MPFNAIYKYTTGSIGAAVFG--VDVDQNTLDTPALNITRKALEPTLKSIMTFFLAGTFPR 163
            P  +I+ YT  +   A+FG  + +  ++  + +LN    ALE   KS +        PR
Sbjct: 189 QP--SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH-ALEVMFKSTVQLMF---MPR 242

Query: 164 -LIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEI 222
            L +W+    +  +  ++ D + +  +N    +K Y  +          ++ +L+   E+
Sbjct: 243 SLSRWIRPKVWKEHFEAW-DCIFQYGDN--CIQKIYQELAFNRPQHYTGIVAELLLKAEL 299

Query: 223 VPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNF 282
             + E +            DTTA  +  TL EL+ NP V + L  E         +    
Sbjct: 300 --SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ- 356

Query: 283 EDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRD 341
           +   +   L   + ET+R YP +GL L+R+ + +  L   N  I   T+  V + +L R+
Sbjct: 357 KATTELPLLRAALKETLRLYP-VGLFLERVVSSDLVL--QNYHIPAGTLVQVFLYSLGRN 413

Query: 342 ERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY- 400
              +P+ + ++PQR+     +  N F  +PFG G R C+G + A  ++   L  +L+ + 
Sbjct: 414 AALFPRPERYNPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL 472

Query: 401 --TLVPQDYKPV 410
             TL  +D K V
Sbjct: 473 VETLTQEDIKMV 484


>U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score = 71.7 bits (168), Expect = 5e-12
 Identities = 53/178 (29%), Positives = 85/178 (47%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  +H+  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLHYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K  I V P+L ++ RD RF+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKG-IEVFPMLGSVLRDLRFFSNPRDFNPQHFLG 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E      + +F+PF    R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 EKGQFKKRDAFVPFSIRKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.
          Length = 480

 Score = 71.7 bits (168), Expect = 5e-12
 Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 6/167 (3%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT+  + + LL L  +P V  K+  EID V    +     +D     Y + VV+E  R 
Sbjct: 290 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDAVVHEIQRY 348

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P G+   + T +T     N  I K T  +  + ++  D++ +P  + FDP  F  +
Sbjct: 349 SDLVPTGVPHAVTT-DTKF--RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGLFLDK 405

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQD 406
           N N      F+PF  G R+C G   AR++L   L  +L+ + L   D
Sbjct: 406 NGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVD 452


>M32881-1|AAA35741.1|  503|Homo sapiens protein ( Human steroid
           11-beta-hydroxylase-like-enzyme (CYP11B2) gene, exon 9.
           ).
          Length = 503

 Score = 71.3 bits (167), Expect = 6e-12
 Identities = 88/372 (23%), Positives = 166/372 (44%), Gaps = 29/372 (7%)

Query: 52  LFIDDLPRWKILRQKLSP-AFSSLRLKTMFEGIERSARDFVE-----FIENSGNDQDLEE 105
           +F+ + P W+  R +L+P   S   ++     ++  ARDF +      ++N+     L+ 
Sbjct: 129 VFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALRKKVLQNARGSLTLDV 188

Query: 106 MPFNAIYKYTTGSIGAAVFG--VDVDQNTLDTPALNITRKALEPTLKSIMTFFLAGTFPR 163
            P  +I+ YT  +   A+FG  + +  ++  + +LN    ALE   KS +        PR
Sbjct: 189 QP--SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH-ALEVMFKSTVQLMF---MPR 242

Query: 164 -LIKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEI 222
            L +W+    +  +  ++ D + +  +N    +K Y  +          ++ +L+   E+
Sbjct: 243 SLSRWISPKVWKEHFEAW-DCIFQYGDN--CIQKIYQELAFNRPQHYTGIVAELLLKAEL 299

Query: 223 VPTDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNF 282
             + E +            DTTA  +  TL EL+ NP V + L  E         +    
Sbjct: 300 --SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRKESLAAAASISEHPQ- 356

Query: 283 EDMDKFKYLEMVVNETMRKYPPIGL-LQRICTKETNLPSNNLRISKDTIAVVPVLALHRD 341
           +   +   L   + ET+R YP +GL L+R+ + +  L   N  I   T+  V + +L R+
Sbjct: 357 KATTELPLLRAALKETLRLYP-VGLFLERVVSSDLVL--QNYHIPAGTLVQVFLYSLGRN 413

Query: 342 ERFYPKSDAFDPQRFAPENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY- 400
              +P+ + ++PQR+     +  N    +PFG G R C+G + A  ++   L  +L+++ 
Sbjct: 414 AALFPRPERYNPQRWLDIRGSGRN-LHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKRFL 472

Query: 401 --TLVPQDYKPV 410
             TL  +D K V
Sbjct: 473 VETLTQEDIKMV 484


>AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13
           variant 6 protein.
          Length = 494

 Score = 71.3 bits (167), Expect = 6e-12
 Identities = 51/173 (29%), Positives = 82/173 (47%), Gaps = 9/173 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P +  K+H EID V    ++   FED  K  Y E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPELEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+GL  R+  K+T     +  + K T  V P+L ++ RD RF+     F+PQ F  
Sbjct: 363 GDMLPMGLAHRV-NKDTKF--RDFFLPKGT-EVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPV 410
           +        +F+PF  G R C G   AR++L      +++ +    PQ  K +
Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDI 471


>U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score = 70.9 bits (166), Expect = 8e-12
 Identities = 52/173 (30%), Positives = 78/173 (45%), Gaps = 9/173 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYTEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALH-RDERFYPKSDAFDPQRFAP 358
               P+GL  R+  K+T     +  + K T  V P+L    RD RF+       PQ F  
Sbjct: 363 GDMLPMGLAHRV-NKDTKF--RDFFLPKGT-EVFPMLGSELRDPRFFSNPQDCSPQHFLD 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKPV 410
           E        +F+PF  G R C G   AR++L      +++ +    PQ  K +
Sbjct: 419 EKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDI 471


>BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score = 70.9 bits (166), Expect = 8e-12
 Identities = 45/171 (26%), Positives = 85/171 (49%), Gaps = 7/171 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT NV+ + +L ++  P++  ++  EID +     K  +++D  K  Y E V++E +R 
Sbjct: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLHEVLRF 371

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P+G+     T E  +      I K T  +  + ++H DE+++   + F P+RF   
Sbjct: 372 CNIVPLGIFH--ATSEDAVV-RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS 428

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKP 409
           +     K + +PF  G R C+G   AR+++      LL+++ L  P +  P
Sbjct: 429 SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP 479


>BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score = 70.9 bits (166), Expect = 8e-12
 Identities = 45/171 (26%), Positives = 85/171 (49%), Gaps = 7/171 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT NV+ + +L ++  P++  ++  EID +     K  +++D  K  Y E V++E +R 
Sbjct: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLHEVLRF 371

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P+G+     T E  +      I K T  +  + ++H DE+++   + F P+RF   
Sbjct: 372 CNIVPLGIFH--ATSEDAVV-RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS 428

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKP 409
           +     K + +PF  G R C+G   AR+++      LL+++ L  P +  P
Sbjct: 429 SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP 479


>AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1
           protein.
          Length = 501

 Score = 70.9 bits (166), Expect = 8e-12
 Identities = 45/171 (26%), Positives = 85/171 (49%), Gaps = 7/171 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +TT NV+ + +L ++  P++  ++  EID +     K  +++D  K  Y E V++E +R 
Sbjct: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLHEVLRF 371

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
               P+G+     T E  +      I K T  +  + ++H DE+++   + F P+RF   
Sbjct: 372 CNIVPLGIFH--ATSEDAVV-RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS 428

Query: 360 NFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL-VPQDYKP 409
           +     K + +PF  G R C+G   AR+++      LL+++ L  P +  P
Sbjct: 429 SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP 479


>AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 variant protein.
          Length = 490

 Score = 70.9 bits (166), Expect = 8e-12
 Identities = 89/405 (21%), Positives = 165/405 (40%), Gaps = 28/405 (6%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKILRQKLS 68
           G +P ++L     ++  L    + F  RG   ++EK      ILF +   RWK +R+   
Sbjct: 70  GLKPIVVLHGYEAVKEALIDHGEEFFGRGSFPVAEKVNKGLGILFSNG-KRWKEIRRFCL 128

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
               +  +  +++ + ++  AR  VE +  + N    +  P   +       I + +F  
Sbjct: 129 MTLRNFGMGKRSIEDRVQEEARCLVEELRKT-NASPCD--PTFILGCAPCNVICSVIFHD 185

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLD------MMNFDNYETS 179
             D    D   LN+  K  E   + S     +   FP LI +L         NF   ++ 
Sbjct: 186 RFDYK--DQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +K+  E+      + DFID C  ++  +   +  + + +    E L          
Sbjct: 244 VLERIKEHQESLDMNSAR-DFID-CFLIKMEQEKHNQQSEFTV----ESLIATVTDMFGA 297

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT+  + + LL L   P V  K+  EI+ V    +     +D     Y + VV+E  
Sbjct: 298 GTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQ 356

Query: 300 RKYP--PIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFA 357
           R     P  L   +     ++   N  I K T  +  + ++  +++ +P  + FDP  F 
Sbjct: 357 RYIDLLPTNLPHAVTC---DVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFL 413

Query: 358 PENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
            ++ N      F+PF  G R+C+G   AR++L   L  +L+ + L
Sbjct: 414 DKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458


>X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mRNA
           for P-450 IIA4 protein. ).
          Length = 494

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is 3rd
           base in codon) protein.
          Length = 448

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 258 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 316

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 317 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVYPMLGSVLRDPSFFSNPQDFNPQHFLN 372

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 373 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 429


>M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.
          Length = 494

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.
          Length = 494

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 48/164 (29%), Positives = 79/164 (48%), Gaps = 8/164 (4%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRTKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVFPMLGSVLRDPSFFSNPQDFNPQHFLD 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTL 402
           +        +F+PF  G R C G   AR++L      +++ + L
Sbjct: 419 DKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRL 462


>L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18
           protein.
          Length = 490

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 98/422 (23%), Positives = 169/422 (40%), Gaps = 31/422 (7%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGII-LSEKETLADSILFIDDLPRWKILRQKLS 68
           G +P ++L     ++  L    + F  RG   ++EK      ILF +   RWK +R+   
Sbjct: 70  GLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNG-KRWKEIRRFCL 128

Query: 69  PAFSSLRL--KTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
               +  +  +++ + ++  AR  VE +  + N    +  P   +       I + +F  
Sbjct: 129 MTLRNFGMGKRSIEDRVQEEARCLVEELRKT-NASPCD--PTFILGCAPCNVICSVIFHD 185

Query: 127 DVDQNTLDTPALNITRKALEPT-LKSIMTFFLAGTFPRLIKWLD------MMNFDNYETS 179
             D    D   LN+  K  E   + S     +   FP LI +L         NF   ++ 
Sbjct: 186 RFDYK--DQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +K+  E+      + DFID C  ++  +   +  + + +    E L          
Sbjct: 244 VLERIKEHQESLDMNSAR-DFID-CFLIKMEQEKHNQQSEFTV----ESLIATVTDMFGA 297

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETM 299
             +TT+  + + LL L   P V  K+  EI+ V    +     +D     Y + VV+E  
Sbjct: 298 GTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQ 356

Query: 300 RKYP--PIGLLQRICTKETNLPSNNLRISKD-TIAVVPVLALHRDERFYPKSDAFDPQRF 356
           R     P  L   +     ++   N  I K  TI       LH D+ F P  + FDP  F
Sbjct: 357 RYIDLLPTNLPHAVTC---DVKFKNYLIPKGMTIITSLTSVLHNDKEF-PNPEMFDPGHF 412

Query: 357 APENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
             ++ N      F+PF  G R+C+G   AR++L   L  +L+ + L  Q   P   + +P
Sbjct: 413 LDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQ-VDPKDIDITP 471

Query: 417 FA 418
            A
Sbjct: 472 IA 473


>BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 7 protein.
          Length = 494

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 51/178 (28%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVFPMLGSVLRDPSFFSNPQDFNPQHFLD 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           +        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 DKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6
           protein.
          Length = 494

 Score = 70.5 bits (165), Expect = 1e-11
 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>DQ680079-1|ABG25922.1|  347|Homo sapiens truncated cytochrome P450,
           family 3, subfamily A, polypeptide 5 protein.
          Length = 347

 Score = 69.7 bits (163), Expect = 2e-11
 Identities = 75/273 (27%), Positives = 122/273 (44%), Gaps = 21/273 (7%)

Query: 10  GRRPAIILKDLRDIQAVLSGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILRQKLSP 69
           G+ P + + D   I+ VL  +  S  +    L     +  +I   +D   WK +R  LSP
Sbjct: 77  GQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAED-EEWKRIRSLLSP 135

Query: 70  AFSSLRLKTMFEGIERSARDFVEFIENS---GNDQDLEEMPFNAIYKYTTGSIGAAVFGV 126
            F+S +LK MF  I +     V  +      G    L+++ F A   Y+   I    FGV
Sbjct: 136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI-FGA---YSMDVITGTSFGV 191

Query: 127 DVDQ-NTLDTPALNITRKAL-----EPTLKSIMTF-FLAGTFPRLIKWLDMMNFDNYETS 179
           ++D  N    P +  T+K L     +P   SI+ F FL   F  L   L   +  N+ + 
Sbjct: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251

Query: 180 FIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLXXXXXXXXXX 239
            ++ +KK   N +  + + DF+ + ++ QN +      T      +D  L          
Sbjct: 252 SVNRMKKSRLNDKQ-KHRLDFLQLMIDSQNSKE-----TESHKALSDLELAAQSIIFIFA 305

Query: 240 XXDTTANVMHFTLLELSSNPSVLKKLHAEIDEV 272
             +TT++V+ FTL EL+++P V +KL  EID V
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAV 338


>U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score = 69.3 bits (162), Expect = 2e-11
 Identities = 52/178 (29%), Positives = 84/178 (47%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  K+H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP-KFEDRTKMPYMEAVIHEIQRF 362

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD RF+     F+PQ F  
Sbjct: 363 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVFPMLGSVLRDLRFFSNPRDFNPQHFLG 418

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E      + +F+PF    R C G   AR++L      +++ + L      P   + SP
Sbjct: 419 EKGQFKKRDAFVPFSIRKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 475


>AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score = 69.3 bits (162), Expect = 2e-11
 Identities = 49/166 (29%), Positives = 80/166 (48%), Gaps = 9/166 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKT--LNFEDMDKFKYLEMVVNETM 299
           +TTAN + + ++ L  +P + ++L  E+D     G  +  + ++D  +   L   + E +
Sbjct: 294 ETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVL 353

Query: 300 RKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPE 359
           R  P + L    CT   +  S    I + T+ +  +   H DE  + +     P  F P+
Sbjct: 354 RLRPVVPLALPHCTTRPSSISG-YDIPEGTVIIPNLQGAHLDETVWER-----PHEFWPD 407

Query: 360 NFNEINKFS-FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVP 404
            F E  K S  L FG G RVC+G   ARL+L   L  LL+ +TL+P
Sbjct: 408 RFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP 453


>X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for
           cytochrome P-450IIA. ).
          Length = 489

 Score = 68.9 bits (161), Expect = 3e-11
 Identities = 51/178 (28%), Positives = 83/178 (46%), Gaps = 9/178 (5%)

Query: 242 DTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMR- 300
           +T +  + +  L L  +P V  ++H EID V    ++   FED  K  Y+E V++E  R 
Sbjct: 299 ETVSTTLRYGFLLLMKHPEVEAQVHEEIDRVIGKNRQP-KFEDRAKMPYMEAVIHEIQRF 357

Query: 301 -KYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVL-ALHRDERFYPKSDAFDPQRFAP 358
               P+ L +R+  K+T     +  + K T  V P+L ++ RD  F+     F+PQ F  
Sbjct: 358 GDVIPMSLARRV-KKDTKF--RDFFLPKGT-EVYPMLGSVLRDPSFFSNPQDFNPQHFLN 413

Query: 359 ENFNEINKFSFLPFGEGNRVCIGAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSP 416
           E        +F+PF  G R C G   AR++L      +++ + L      P   + SP
Sbjct: 414 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL-KSSQSPKDIDVSP 470


>M28420-1|AAA52141.1|  419|Homo sapiens cytochrome P-450 aromatase
           protein.
          Length = 419

 Score = 68.5 bits (160), Expect = 4e-11
 Identities = 57/237 (24%), Positives = 107/237 (45%), Gaps = 16/237 (6%)

Query: 165 IKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVP 224
           I WL    ++       DA++ ++  +R      + ++ C++     +L +         
Sbjct: 153 ISWL-YKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGDL---- 207

Query: 225 TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFED 284
           T E +            DT +  + F L  ++ +P+V + +  EI  V   G++ +  +D
Sbjct: 208 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI--GERDIKIDD 265

Query: 285 MDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERF 344
           + K K +E  + E+MR  P + L+ R   ++  +  +   + K T  ++ +  +HR E F
Sbjct: 266 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRLE-F 322

Query: 345 YPKSDAFDPQRFAPENFNEINKFS-FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +PK     P  F  ENF +   +  F PFG G R C G   A + ++A L  LLR++
Sbjct: 323 FPK-----PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 374


>J04127-1|AAA52132.1|  503|Homo sapiens CYP19 protein.
          Length = 503

 Score = 68.5 bits (160), Expect = 4e-11
 Identities = 57/237 (24%), Positives = 107/237 (45%), Gaps = 16/237 (6%)

Query: 165 IKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVP 224
           I WL    ++       DA++ ++  +R      + ++ C++     +L +         
Sbjct: 237 ISWL-YKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGDL---- 291

Query: 225 TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFED 284
           T E +            DT +  + F L  ++ +P+V + +  EI  V   G++ +  +D
Sbjct: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI--GERDIKIDD 349

Query: 285 MDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERF 344
           + K K +E  + E+MR  P + L+ R   ++  +  +   + K T  ++ +  +HR E F
Sbjct: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRLE-F 406

Query: 345 YPKSDAFDPQRFAPENFNEINKFS-FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +PK     P  F  ENF +   +  F PFG G R C G   A + ++A L  LLR++
Sbjct: 407 FPK-----PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458


>Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for
           aromatase P-450. ).
          Length = 503

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 57/237 (24%), Positives = 107/237 (45%), Gaps = 16/237 (6%)

Query: 165 IKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVP 224
           I WL    ++       DA++ ++  +R      + ++ C++     +L +         
Sbjct: 237 ISWL-YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL---- 291

Query: 225 TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFED 284
           T E +            DT +  + F L  ++ +P+V + +  EI  V   G++ +  +D
Sbjct: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI--GERDIKIDD 349

Query: 285 MDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERF 344
           + K K +E  + E+MR  P + L+ R   ++  +  +   + K T  ++ +  +HR E F
Sbjct: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRLE-F 406

Query: 345 YPKSDAFDPQRFAPENFNEINKFS-FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +PK     P  F  ENF +   +  F PFG G R C G   A + ++A L  LLR++
Sbjct: 407 FPK-----PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458


>X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for
           aromatase (estrogen synthetase). ).
          Length = 503

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 57/237 (24%), Positives = 107/237 (45%), Gaps = 16/237 (6%)

Query: 165 IKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVP 224
           I WL    ++       DA++ ++  +R      + ++ C++     +L +         
Sbjct: 237 ISWL-YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL---- 291

Query: 225 TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFED 284
           T E +            DT +  + F L  ++ +P+V + +  EI  V   G++ +  +D
Sbjct: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI--GERDIKIDD 349

Query: 285 MDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERF 344
           + K K +E  + E+MR  P + L+ R   ++  +  +   + K T  ++ +  +HR E F
Sbjct: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRLE-F 406

Query: 345 YPKSDAFDPQRFAPENFNEINKFS-FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +PK     P  F  ENF +   +  F PFG G R C G   A + ++A L  LLR++
Sbjct: 407 FPK-----PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458


>M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase
           cytochrome P-450 gene, exon 10. ).
          Length = 503

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 57/237 (24%), Positives = 107/237 (45%), Gaps = 16/237 (6%)

Query: 165 IKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVP 224
           I WL    ++       DA++ ++  +R      + ++ C++     +L +         
Sbjct: 237 ISWL-YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL---- 291

Query: 225 TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFED 284
           T E +            DT +  + F L  ++ +P+V + +  EI  V   G++ +  +D
Sbjct: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI--GERDIKIDD 349

Query: 285 MDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERF 344
           + K K +E  + E+MR  P + L+ R   ++  +  +   + K T  ++ +  +HR E F
Sbjct: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRLE-F 406

Query: 345 YPKSDAFDPQRFAPENFNEINKFS-FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +PK     P  F  ENF +   +  F PFG G R C G   A + ++A L  LLR++
Sbjct: 407 FPK-----PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458


>M22246-1|AAA35557.1|  503|Homo sapiens protein ( Human aromatase
           mRNA, complete cds. ).
          Length = 503

 Score = 68.1 bits (159), Expect = 6e-11
 Identities = 57/237 (24%), Positives = 107/237 (45%), Gaps = 16/237 (6%)

Query: 165 IKWLDMMNFDNYETSFIDAVKKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVP 224
           I WL    ++       DA++ ++  +R      + ++ C++     +L +         
Sbjct: 237 ISWL-YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL---- 291

Query: 225 TDELLXXXXXXXXXXXXDTTANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFED 284
           T E +            DT +  + F L  ++ +P+V + +  EI  V   G++ +  +D
Sbjct: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI--GERDIKIDD 349

Query: 285 MDKFKYLEMVVNETMRKYPPIGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERF 344
           + K K +E  + E+MR  P + L+ R   ++  +  +   + K T  ++ +  +HR E F
Sbjct: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHRLE-F 406

Query: 345 YPKSDAFDPQRFAPENFNEINKFS-FLPFGEGNRVCIGAKFARLQLRAGLAWLLRKY 400
           +PK     P  F  ENF +   +  F PFG G R C G   A + ++A L  LLR++
Sbjct: 407 FPK-----PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.322    0.138    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 58,210,220
Number of Sequences: 224733
Number of extensions: 2370615
Number of successful extensions: 5982
Number of sequences better than 10.0: 455
Number of HSP's better than 10.0 without gapping: 333
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 4904
Number of HSP's gapped (non-prelim): 519
length of query: 433
length of database: 73,234,838
effective HSP length: 92
effective length of query: 341
effective length of database: 52,559,402
effective search space: 17922756082
effective search space used: 17922756082
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 67 (31.1 bits)