Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002161-TA|BGIBMGA002161-PA|IPR001373|Cullin
(691 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U83410-1|AAC51190.1| 745|Homo sapiens CUL-2 protein. 210 9e-54
U58088-1|AAC50545.1| 651|Homo sapiens Hs-CUL-2 protein. 210 9e-54
BC110901-1|AAI10902.1| 745|Homo sapiens CUL2 protein protein. 210 9e-54
BC009591-1|AAH09591.1| 745|Homo sapiens cullin 2 protein. 210 9e-54
AL392046-3|CAI13164.1| 706|Homo sapiens cullin 2 protein. 210 9e-54
AL392046-2|CAI13163.1| 745|Homo sapiens cullin 2 protein. 210 9e-54
AL392046-1|CAI13162.1| 688|Homo sapiens cullin 2 protein. 210 9e-54
AF126404-1|AAD23581.1| 745|Homo sapiens cullin 2 protein. 210 9e-54
U58087-1|AAC50544.1| 752|Homo sapiens Hs-CUL-1 protein. 162 4e-39
BX537409-1|CAD97651.1| 776|Homo sapiens hypothetical protein pr... 162 4e-39
BC125120-1|AAI25121.1| 776|Homo sapiens cullin 1 protein. 162 4e-39
BC125119-1|AAI25120.1| 776|Homo sapiens cullin 1 protein. 162 4e-39
AF062536-1|AAC36681.1| 776|Homo sapiens cullin 1 protein. 162 4e-39
AC006323-3|AAS02034.1| 513|Homo sapiens unknown protein. 162 4e-39
AL392046-4|CAI13165.1| 216|Homo sapiens cullin 2 protein. 133 2e-30
X81882-1|CAA57465.1| 780|Homo sapiens vasopressin activated cal... 111 8e-24
BC063306-1|AAH63306.1| 780|Homo sapiens cullin 5 protein. 111 8e-24
AF327710-1|AAK07472.1| 780|Homo sapiens cullin 5 protein. 111 8e-24
AF017061-1|AAB70253.1| 781|Homo sapiens vasopressin-activated c... 111 8e-24
BX537787-1|CAD97843.1| 895|Homo sapiens hypothetical protein pr... 95 6e-19
BC036216-1|AAH36216.1| 913|Homo sapiens cullin 4B protein. 95 6e-19
AY365125-1|AAR13073.1| 895|Homo sapiens cullin 4B protein. 95 6e-19
AL451005-1|CAI41370.1| 913|Homo sapiens cullin 4B protein. 95 6e-19
AC002476-3|AAB67315.1| 652|Homo sapiens WUGSC:H_DJ318C15.2 prot... 95 6e-19
AB014595-1|BAA31670.2| 781|Homo sapiens KIAA0695 protein protein. 95 6e-19
U58089-1|AAC50546.1| 577|Homo sapiens Hs-CUL-3 protein. 91 9e-18
BC092409-1|AAH92409.1| 768|Homo sapiens cullin 3 protein. 91 9e-18
BC039598-1|AAH39598.1| 768|Homo sapiens cullin 3 protein. 91 9e-18
AF064087-1|AAC36304.1| 768|Homo sapiens cullin 3 protein. 91 9e-18
AF062537-1|AAC36682.1| 768|Homo sapiens cullin 3 protein. 91 9e-18
AC073052-1|AAX93287.1| 746|Homo sapiens unknown protein. 91 9e-18
AB014517-1|BAA31592.2| 786|Homo sapiens KIAA0617 protein protein. 91 9e-18
AY337761-1|AAQ01660.1| 744|Homo sapiens cullin 3 isoform protein. 91 1e-17
AF212995-1|AAK16812.1| 782|Homo sapiens cullin CUL4B protein. 90 2e-17
U58090-1|AAC50547.1| 421|Homo sapiens Hs-CUL-4A protein. 87 3e-16
BC008308-1|AAH08308.2| 759|Homo sapiens cullin 4A protein. 87 3e-16
AY365124-1|AAR13072.1| 759|Homo sapiens cullin 4A protein. 87 3e-16
AL136221-5|CAI13795.1| 659|Homo sapiens cullin 4A protein. 87 3e-16
AL136221-4|CAM18410.1| 759|Homo sapiens cullin 4A protein. 87 3e-16
AF077188-1|AAD45191.1| 659|Homo sapiens cullin 4A protein. 87 3e-16
AB178950-1|BAD93235.1| 759|Homo sapiens cullin-4A protein. 87 3e-16
AB012193-1|BAA33146.1| 524|Homo sapiens cullin-4A protein. 87 3e-16
BC031844-1|AAH31844.1| 373|Homo sapiens CUL3 protein protein. 80 3e-14
U58091-1|AAC50548.1| 288|Homo sapiens Hs-CUL-4B protein. 48 1e-04
AF052147-1|AAC28621.1| 343|Homo sapiens cul-3 protein. 44 0.001
BC032503-1|AAH32503.1| 822|Homo sapiens anaphase promoting comp... 40 0.022
BC001579-1|AAH01579.1| 577|Homo sapiens ANAPC2 protein protein. 40 0.022
AL929554-12|CAH72881.1| 822|Homo sapiens anaphase promoting com... 40 0.022
AF191337-1|AAF05751.1| 822|Homo sapiens anaphase-promoting comp... 40 0.022
AB037827-1|BAA92644.1| 571|Homo sapiens KIAA1406 protein protein. 40 0.022
D38548-1|BAA07551.2| 1701|Homo sapiens KIAA0076 protein. 33 2.6
BC033647-1|AAH33647.1| 1698|Homo sapiens cullin 7 protein. 33 2.6
AL355385-1|CAI13779.1| 1698|Homo sapiens cullin 7 protein. 33 2.6
AL136304-2|CAI19793.1| 1698|Homo sapiens cullin 7 protein. 33 2.6
>U83410-1|AAC51190.1| 745|Homo sapiens CUL-2 protein.
Length = 745
Score = 210 bits (514), Expect = 9e-54
Identities = 95/171 (55%), Positives = 129/171 (75%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWV 575
FVE++L +HGK+ +L N V G Q FM ALDKA ++VVN R + C+APEL+A+YCD +
Sbjct: 339 FVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNL 398
Query: 576 LRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMI 635
L++ +V+D+LT+ I VFKYIDDKD+FQK YAR LA+RLIH LS SM+ EE+MI
Sbjct: 399 LKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 458
Query: 636 NRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
N+LK ACGYEFT+KLHRM+TD++VSADLN KF ++++ D ++ G Q+
Sbjct: 459 NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQI 509
Score = 153 bits (372), Expect = 2e-36
Identities = 85/236 (36%), Positives = 128/236 (54%), Gaps = 14/236 (5%)
Query: 51 TQVAGVVGLKAVDRIVWNTRFSDVYALCVAHPEPLADRLYDETRNFLEEHVASLLERVRG 110
T + VV L+ V+R WN RFSD+YALCVA+PEPL +RLY ET+ FLE HV L +RV
Sbjct: 19 TTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRV-- 76
Query: 111 STTLEQSDHNDGLLDRYVSAWREYSQGVAXXXXXXXXXXXQHVKRQKVSDAEIIYGTSAT 170
LE + +L Y W EYS+G Q +K+ K+++A++ YG
Sbjct: 77 ---LESEEQ---VLVMYHRYWEEYSKGADYMDCLYRYLSTQFIKKNKLTEADLQYGYGGV 130
Query: 171 VSCPEQDARQLEVGELGLDIWERVLVRPLSAALTARIVSALXXXXXXXXXXXXXXIIRQA 230
+ + +E+GEL LD+W +++V PL A L ++ + +I
Sbjct: 131 ----DMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREI--KNDRGGEDPNQKVIHGV 184
Query: 231 IQSTVHVRSFRVRSPLALYEQLVLEPFLQAAGEQHARTAAHLLQEGDVAHYMKHVL 286
I S VHV ++ + PL Y+++ PFL GE + + A++LLQE + + YM+ VL
Sbjct: 185 INSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL 240
Score = 32.7 bits (71), Expect = 4.5
Identities = 14/21 (66%), Positives = 15/21 (71%)
Query: 1 MSLKPRHVDFQETWANLKETV 21
MSLKPR VDF ETW L T+
Sbjct: 1 MSLKPRVVDFDETWNKLLTTI 21
>U58088-1|AAC50545.1| 651|Homo sapiens Hs-CUL-2 protein.
Length = 651
Score = 210 bits (514), Expect = 9e-54
Identities = 95/171 (55%), Positives = 129/171 (75%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWV 575
FVE++L +HGK+ +L N V G Q FM ALDKA ++VVN R + C+APEL+A+YCD +
Sbjct: 245 FVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNL 304
Query: 576 LRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMI 635
L++ +V+D+LT+ I VFKYIDDKD+FQK YAR LA+RLIH LS SM+ EE+MI
Sbjct: 305 LKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 364
Query: 636 NRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
N+LK ACGYEFT+KLHRM+TD++VSADLN KF ++++ D ++ G Q+
Sbjct: 365 NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQI 415
Score = 79.8 bits (188), Expect = 3e-14
Identities = 41/136 (30%), Positives = 73/136 (53%), Gaps = 6/136 (4%)
Query: 151 QHVKRQKVSDAEIIYGTSATVSCPEQDARQLEVGELGLDIWERVLVRPLSAALTARIVSA 210
Q +K+ K+++A++ YG + + +E+GEL LD+W +++V PL A L ++
Sbjct: 17 QFIKKNKLTEADLQYGYGGV----DMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLRE 72
Query: 211 LXXXXXXXXXXXXXXIIRQAIQSTVHVRSFRVRSPLALYEQLVLEPFLQAAGEQHARTAA 270
+ +I I S VHV ++ + PL Y+++ PFL GE + + A+
Sbjct: 73 IKNDRGGEDPNQK--VIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEAS 130
Query: 271 HLLQEGDVAHYMKHVL 286
+LLQE + + YM+ VL
Sbjct: 131 NLLQESNCSQYMEKVL 146
>BC110901-1|AAI10902.1| 745|Homo sapiens CUL2 protein protein.
Length = 745
Score = 210 bits (514), Expect = 9e-54
Identities = 95/171 (55%), Positives = 129/171 (75%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWV 575
FVE++L +HGK+ +L N V G Q FM ALDKA ++VVN R + C+APEL+A+YCD +
Sbjct: 339 FVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNL 398
Query: 576 LRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMI 635
L++ +V+D+LT+ I VFKYIDDKD+FQK YAR LA+RLIH LS SM+ EE+MI
Sbjct: 399 LKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 458
Query: 636 NRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
N+LK ACGYEFT+KLHRM+TD++VSADLN KF ++++ D ++ G Q+
Sbjct: 459 NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQI 509
Score = 153 bits (371), Expect = 2e-36
Identities = 85/236 (36%), Positives = 128/236 (54%), Gaps = 14/236 (5%)
Query: 51 TQVAGVVGLKAVDRIVWNTRFSDVYALCVAHPEPLADRLYDETRNFLEEHVASLLERVRG 110
T + VV L+ V+R WN RFSD+YALCVA+PEPL +RLY ET+ FLE HV L +RV
Sbjct: 19 TTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRV-- 76
Query: 111 STTLEQSDHNDGLLDRYVSAWREYSQGVAXXXXXXXXXXXQHVKRQKVSDAEIIYGTSAT 170
LE + +L Y W EYS+G Q +K+ K+++A++ YG
Sbjct: 77 ---LESEEQ---VLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGV 130
Query: 171 VSCPEQDARQLEVGELGLDIWERVLVRPLSAALTARIVSALXXXXXXXXXXXXXXIIRQA 230
+ + +E+GEL LD+W +++V PL A L ++ + +I
Sbjct: 131 ----DMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREI--KNDRGGEDPNQKVIHGV 184
Query: 231 IQSTVHVRSFRVRSPLALYEQLVLEPFLQAAGEQHARTAAHLLQEGDVAHYMKHVL 286
I S VHV ++ + PL Y+++ PFL GE + + A++LLQE + + YM+ VL
Sbjct: 185 INSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL 240
Score = 32.7 bits (71), Expect = 4.5
Identities = 14/21 (66%), Positives = 15/21 (71%)
Query: 1 MSLKPRHVDFQETWANLKETV 21
MSLKPR VDF ETW L T+
Sbjct: 1 MSLKPRVVDFDETWNKLLTTI 21
>BC009591-1|AAH09591.1| 745|Homo sapiens cullin 2 protein.
Length = 745
Score = 210 bits (514), Expect = 9e-54
Identities = 95/171 (55%), Positives = 129/171 (75%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWV 575
FVE++L +HGK+ +L N V G Q FM ALDKA ++VVN R + C+APEL+A+YCD +
Sbjct: 339 FVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNL 398
Query: 576 LRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMI 635
L++ +V+D+LT+ I VFKYIDDKD+FQK YAR LA+RLIH LS SM+ EE+MI
Sbjct: 399 LKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 458
Query: 636 NRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
N+LK ACGYEFT+KLHRM+TD++VSADLN KF ++++ D ++ G Q+
Sbjct: 459 NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQI 509
Score = 153 bits (371), Expect = 2e-36
Identities = 85/236 (36%), Positives = 128/236 (54%), Gaps = 14/236 (5%)
Query: 51 TQVAGVVGLKAVDRIVWNTRFSDVYALCVAHPEPLADRLYDETRNFLEEHVASLLERVRG 110
T + VV L+ V+R WN RFSD+YALCVA+PEPL +RLY ET+ FLE HV L +RV
Sbjct: 19 TTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRV-- 76
Query: 111 STTLEQSDHNDGLLDRYVSAWREYSQGVAXXXXXXXXXXXQHVKRQKVSDAEIIYGTSAT 170
LE + +L Y W EYS+G Q +K+ K+++A++ YG
Sbjct: 77 ---LESEEQ---VLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGV 130
Query: 171 VSCPEQDARQLEVGELGLDIWERVLVRPLSAALTARIVSALXXXXXXXXXXXXXXIIRQA 230
+ + +E+GEL LD+W +++V PL A L ++ + +I
Sbjct: 131 ----DMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREI--KNDRGGEDPNQKVIHGV 184
Query: 231 IQSTVHVRSFRVRSPLALYEQLVLEPFLQAAGEQHARTAAHLLQEGDVAHYMKHVL 286
I S VHV ++ + PL Y+++ PFL GE + + A++LLQE + + YM+ VL
Sbjct: 185 INSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL 240
Score = 32.7 bits (71), Expect = 4.5
Identities = 14/21 (66%), Positives = 15/21 (71%)
Query: 1 MSLKPRHVDFQETWANLKETV 21
MSLKPR VDF ETW L T+
Sbjct: 1 MSLKPRVVDFDETWNKLLTTI 21
>AL392046-3|CAI13164.1| 706|Homo sapiens cullin 2 protein.
Length = 706
Score = 210 bits (514), Expect = 9e-54
Identities = 95/171 (55%), Positives = 129/171 (75%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWV 575
FVE++L +HGK+ +L N V G Q FM ALDKA ++VVN R + C+APEL+A+YCD +
Sbjct: 339 FVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNL 398
Query: 576 LRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMI 635
L++ +V+D+LT+ I VFKYIDDKD+FQK YAR LA+RLIH LS SM+ EE+MI
Sbjct: 399 LKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 458
Query: 636 NRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
N+LK ACGYEFT+KLHRM+TD++VSADLN KF ++++ D ++ G Q+
Sbjct: 459 NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQI 509
Score = 153 bits (371), Expect = 2e-36
Identities = 85/236 (36%), Positives = 128/236 (54%), Gaps = 14/236 (5%)
Query: 51 TQVAGVVGLKAVDRIVWNTRFSDVYALCVAHPEPLADRLYDETRNFLEEHVASLLERVRG 110
T + VV L+ V+R WN RFSD+YALCVA+PEPL +RLY ET+ FLE HV L +RV
Sbjct: 19 TTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRV-- 76
Query: 111 STTLEQSDHNDGLLDRYVSAWREYSQGVAXXXXXXXXXXXQHVKRQKVSDAEIIYGTSAT 170
LE + +L Y W EYS+G Q +K+ K+++A++ YG
Sbjct: 77 ---LESEEQ---VLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGV 130
Query: 171 VSCPEQDARQLEVGELGLDIWERVLVRPLSAALTARIVSALXXXXXXXXXXXXXXIIRQA 230
+ + +E+GEL LD+W +++V PL A L ++ + +I
Sbjct: 131 ----DMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREI--KNDRGGEDPNQKVIHGV 184
Query: 231 IQSTVHVRSFRVRSPLALYEQLVLEPFLQAAGEQHARTAAHLLQEGDVAHYMKHVL 286
I S VHV ++ + PL Y+++ PFL GE + + A++LLQE + + YM+ VL
Sbjct: 185 INSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL 240
Score = 32.7 bits (71), Expect = 4.5
Identities = 14/21 (66%), Positives = 15/21 (71%)
Query: 1 MSLKPRHVDFQETWANLKETV 21
MSLKPR VDF ETW L T+
Sbjct: 1 MSLKPRVVDFDETWNKLLTTI 21
>AL392046-2|CAI13163.1| 745|Homo sapiens cullin 2 protein.
Length = 745
Score = 210 bits (514), Expect = 9e-54
Identities = 95/171 (55%), Positives = 129/171 (75%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWV 575
FVE++L +HGK+ +L N V G Q FM ALDKA ++VVN R + C+APEL+A+YCD +
Sbjct: 339 FVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNL 398
Query: 576 LRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMI 635
L++ +V+D+LT+ I VFKYIDDKD+FQK YAR LA+RLIH LS SM+ EE+MI
Sbjct: 399 LKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 458
Query: 636 NRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
N+LK ACGYEFT+KLHRM+TD++VSADLN KF ++++ D ++ G Q+
Sbjct: 459 NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQI 509
Score = 153 bits (371), Expect = 2e-36
Identities = 85/236 (36%), Positives = 128/236 (54%), Gaps = 14/236 (5%)
Query: 51 TQVAGVVGLKAVDRIVWNTRFSDVYALCVAHPEPLADRLYDETRNFLEEHVASLLERVRG 110
T + VV L+ V+R WN RFSD+YALCVA+PEPL +RLY ET+ FLE HV L +RV
Sbjct: 19 TTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRV-- 76
Query: 111 STTLEQSDHNDGLLDRYVSAWREYSQGVAXXXXXXXXXXXQHVKRQKVSDAEIIYGTSAT 170
LE + +L Y W EYS+G Q +K+ K+++A++ YG
Sbjct: 77 ---LESEEQ---VLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGV 130
Query: 171 VSCPEQDARQLEVGELGLDIWERVLVRPLSAALTARIVSALXXXXXXXXXXXXXXIIRQA 230
+ + +E+GEL LD+W +++V PL A L ++ + +I
Sbjct: 131 ----DMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREI--KNDRGGEDPNQKVIHGV 184
Query: 231 IQSTVHVRSFRVRSPLALYEQLVLEPFLQAAGEQHARTAAHLLQEGDVAHYMKHVL 286
I S VHV ++ + PL Y+++ PFL GE + + A++LLQE + + YM+ VL
Sbjct: 185 INSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL 240
Score = 32.7 bits (71), Expect = 4.5
Identities = 14/21 (66%), Positives = 15/21 (71%)
Query: 1 MSLKPRHVDFQETWANLKETV 21
MSLKPR VDF ETW L T+
Sbjct: 1 MSLKPRVVDFDETWNKLLTTI 21
>AL392046-1|CAI13162.1| 688|Homo sapiens cullin 2 protein.
Length = 688
Score = 210 bits (514), Expect = 9e-54
Identities = 95/171 (55%), Positives = 129/171 (75%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWV 575
FVE++L +HGK+ +L N V G Q FM ALDKA ++VVN R + C+APEL+A+YCD +
Sbjct: 282 FVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNL 341
Query: 576 LRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMI 635
L++ +V+D+LT+ I VFKYIDDKD+FQK YAR LA+RLIH LS SM+ EE+MI
Sbjct: 342 LKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 401
Query: 636 NRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
N+LK ACGYEFT+KLHRM+TD++VSADLN KF ++++ D ++ G Q+
Sbjct: 402 NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQI 452
Score = 88.6 bits (210), Expect = 6e-17
Identities = 49/165 (29%), Positives = 83/165 (50%), Gaps = 9/165 (5%)
Query: 122 GLLDRYVSAWREYSQGVAXXXXXXXXXXXQHVKRQKVSDAEIIYGTSATVSCPEQDARQL 181
G+ RY W EYS+G Q +K+ K+++A++ YG + + +
Sbjct: 28 GICIRY---WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGV----DMNEPLM 80
Query: 182 EVGELGLDIWERVLVRPLSAALTARIVSALXXXXXXXXXXXXXXIIRQAIQSTVHVRSFR 241
E+GEL LD+W +++V PL A L ++ + +I I S VHV ++
Sbjct: 81 EIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQK--VIHGVINSFVHVEQYK 138
Query: 242 VRSPLALYEQLVLEPFLQAAGEQHARTAAHLLQEGDVAHYMKHVL 286
+ PL Y+++ PFL GE + + A++LLQE + + YM+ VL
Sbjct: 139 KKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL 183
>AF126404-1|AAD23581.1| 745|Homo sapiens cullin 2 protein.
Length = 745
Score = 210 bits (514), Expect = 9e-54
Identities = 95/171 (55%), Positives = 129/171 (75%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWV 575
FVE++L +HGK+ +L N V G Q FM ALDKA ++VVN R + C+APEL+A+YCD +
Sbjct: 339 FVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNL 398
Query: 576 LRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMI 635
L++ +V+D+LT+ I VFKYIDDKD+FQK YAR LA+RLIH LS SM+ EE+MI
Sbjct: 399 LKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 458
Query: 636 NRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
N+LK ACGYEFT+KLHRM+TD++VSADLN KF ++++ D ++ G Q+
Sbjct: 459 NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQI 509
Score = 153 bits (371), Expect = 2e-36
Identities = 85/236 (36%), Positives = 128/236 (54%), Gaps = 14/236 (5%)
Query: 51 TQVAGVVGLKAVDRIVWNTRFSDVYALCVAHPEPLADRLYDETRNFLEEHVASLLERVRG 110
T + VV L+ V+R WN RFSD+YALCVA+PEPL +RLY ET+ FLE HV L +RV
Sbjct: 19 TTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRV-- 76
Query: 111 STTLEQSDHNDGLLDRYVSAWREYSQGVAXXXXXXXXXXXQHVKRQKVSDAEIIYGTSAT 170
LE + +L Y W EYS+G Q +K+ K+++A++ YG
Sbjct: 77 ---LESEEQ---VLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGV 130
Query: 171 VSCPEQDARQLEVGELGLDIWERVLVRPLSAALTARIVSALXXXXXXXXXXXXXXIIRQA 230
+ + +E+GEL LD+W +++V PL A L ++ + +I
Sbjct: 131 ----DMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREI--KNDRGGEDPNQKVIHGV 184
Query: 231 IQSTVHVRSFRVRSPLALYEQLVLEPFLQAAGEQHARTAAHLLQEGDVAHYMKHVL 286
I S VHV ++ + PL Y+++ PFL GE + + A++LLQE + + YM+ VL
Sbjct: 185 INSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL 240
Score = 32.7 bits (71), Expect = 4.5
Identities = 14/21 (66%), Positives = 15/21 (71%)
Query: 1 MSLKPRHVDFQETWANLKETV 21
MSLKPR VDF ETW L T+
Sbjct: 1 MSLKPRVVDFDETWNKLLTTI 21
>U58087-1|AAC50544.1| 752|Homo sapiens Hs-CUL-1 protein.
Length = 752
Score = 162 bits (393), Expect = 4e-39
Identities = 87/230 (37%), Positives = 134/230 (58%), Gaps = 11/230 (4%)
Query: 463 RREDLSRMYQLVRPL--GPAALRPLVDXXXXXXXXXXXXXXXXXXXXXKDEVHIHFVEAI 520
+ EDL RMY LV + G L+ L++ +V+ +
Sbjct: 291 KNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKM----YVQTV 346
Query: 521 LTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----GEEACRAPELVARYCDWVL 576
L +H KY+ L F F+ ALDKAC +N+ + + + ++PEL+ARYCD +L
Sbjct: 347 LDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLL 406
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
++ +++D L +VVFKYI+DKD+FQK YA+ LA+RL+HQ S S + E SMI+
Sbjct: 407 KKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMIS 466
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
+LK ACG+E+T+KL RMF D+ VS DLN +F+++L +++ L+ F IQ+
Sbjct: 467 KLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQV 515
>BX537409-1|CAD97651.1| 776|Homo sapiens hypothetical protein
protein.
Length = 776
Score = 162 bits (393), Expect = 4e-39
Identities = 87/230 (37%), Positives = 134/230 (58%), Gaps = 11/230 (4%)
Query: 463 RREDLSRMYQLVRPL--GPAALRPLVDXXXXXXXXXXXXXXXXXXXXXKDEVHIHFVEAI 520
+ EDL RMY LV + G L+ L++ +V+ +
Sbjct: 315 KNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKM----YVQTV 370
Query: 521 LTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----GEEACRAPELVARYCDWVL 576
L +H KY+ L F F+ ALDKAC +N+ + + + ++PEL+ARYCD +L
Sbjct: 371 LDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLL 430
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
++ +++D L +VVFKYI+DKD+FQK YA+ LA+RL+HQ S S + E SMI+
Sbjct: 431 KKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMIS 490
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
+LK ACG+E+T+KL RMF D+ VS DLN +F+++L +++ L+ F IQ+
Sbjct: 491 KLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQV 539
>BC125120-1|AAI25121.1| 776|Homo sapiens cullin 1 protein.
Length = 776
Score = 162 bits (393), Expect = 4e-39
Identities = 87/230 (37%), Positives = 134/230 (58%), Gaps = 11/230 (4%)
Query: 463 RREDLSRMYQLVRPL--GPAALRPLVDXXXXXXXXXXXXXXXXXXXXXKDEVHIHFVEAI 520
+ EDL RMY LV + G L+ L++ +V+ +
Sbjct: 315 KNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKM----YVQTV 370
Query: 521 LTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----GEEACRAPELVARYCDWVL 576
L +H KY+ L F F+ ALDKAC +N+ + + + ++PEL+ARYCD +L
Sbjct: 371 LDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLL 430
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
++ +++D L +VVFKYI+DKD+FQK YA+ LA+RL+HQ S S + E SMI+
Sbjct: 431 KKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMIS 490
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
+LK ACG+E+T+KL RMF D+ VS DLN +F+++L +++ L+ F IQ+
Sbjct: 491 KLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQV 539
>BC125119-1|AAI25120.1| 776|Homo sapiens cullin 1 protein.
Length = 776
Score = 162 bits (393), Expect = 4e-39
Identities = 87/230 (37%), Positives = 134/230 (58%), Gaps = 11/230 (4%)
Query: 463 RREDLSRMYQLVRPL--GPAALRPLVDXXXXXXXXXXXXXXXXXXXXXKDEVHIHFVEAI 520
+ EDL RMY LV + G L+ L++ +V+ +
Sbjct: 315 KNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKM----YVQTV 370
Query: 521 LTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----GEEACRAPELVARYCDWVL 576
L +H KY+ L F F+ ALDKAC +N+ + + + ++PEL+ARYCD +L
Sbjct: 371 LDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLL 430
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
++ +++D L +VVFKYI+DKD+FQK YA+ LA+RL+HQ S S + E SMI+
Sbjct: 431 KKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMIS 490
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
+LK ACG+E+T+KL RMF D+ VS DLN +F+++L +++ L+ F IQ+
Sbjct: 491 KLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQV 539
>AF062536-1|AAC36681.1| 776|Homo sapiens cullin 1 protein.
Length = 776
Score = 162 bits (393), Expect = 4e-39
Identities = 87/230 (37%), Positives = 134/230 (58%), Gaps = 11/230 (4%)
Query: 463 RREDLSRMYQLVRPL--GPAALRPLVDXXXXXXXXXXXXXXXXXXXXXKDEVHIHFVEAI 520
+ EDL RMY LV + G L+ L++ +V+ +
Sbjct: 315 KNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKM----YVQTV 370
Query: 521 LTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----GEEACRAPELVARYCDWVL 576
L +H KY+ L F F+ ALDKAC +N+ + + + ++PEL+ARYCD +L
Sbjct: 371 LDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLL 430
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
++ +++D L +VVFKYI+DKD+FQK YA+ LA+RL+HQ S S + E SMI+
Sbjct: 431 KKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMIS 490
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
+LK ACG+E+T+KL RMF D+ VS DLN +F+++L +++ L+ F IQ+
Sbjct: 491 KLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQV 539
>AC006323-3|AAS02034.1| 513|Homo sapiens unknown protein.
Length = 513
Score = 162 bits (393), Expect = 4e-39
Identities = 87/230 (37%), Positives = 134/230 (58%), Gaps = 11/230 (4%)
Query: 463 RREDLSRMYQLVRPL--GPAALRPLVDXXXXXXXXXXXXXXXXXXXXXKDEVHIHFVEAI 520
+ EDL RMY LV + G L+ L++ +V+ +
Sbjct: 52 KNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKM----YVQTV 107
Query: 521 LTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----GEEACRAPELVARYCDWVL 576
L +H KY+ L F F+ ALDKAC +N+ + + + ++PEL+ARYCD +L
Sbjct: 108 LDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLL 167
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
++ +++D L +VVFKYI+DKD+FQK YA+ LA+RL+HQ S S + E SMI+
Sbjct: 168 KKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMIS 227
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLNTGFFIQL 686
+LK ACG+E+T+KL RMF D+ VS DLN +F+++L +++ L+ F IQ+
Sbjct: 228 KLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQV 276
>AL392046-4|CAI13165.1| 216|Homo sapiens cullin 2 protein.
Length = 216
Score = 133 bits (321), Expect = 2e-30
Identities = 75/212 (35%), Positives = 111/212 (52%), Gaps = 14/212 (6%)
Query: 51 TQVAGVVGLKAVDRIVWNTRFSDVYALCVAHPEPLADRLYDETRNFLEEHVASLLERVRG 110
T + VV L+ V+R WN RFSD+YALCVA+PEPL +RLY ET+ FLE HV L +RV
Sbjct: 19 TTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRV-- 76
Query: 111 STTLEQSDHNDGLLDRYVSAWREYSQGVAXXXXXXXXXXXQHVKRQKVSDAEIIYGTSAT 170
LE + +L Y W EYS+G Q +K+ K+++A++ YG
Sbjct: 77 ---LESEEQ---VLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGV 130
Query: 171 VSCPEQDARQLEVGELGLDIWERVLVRPLSAALTARIVSALXXXXXXXXXXXXXXIIRQA 230
+ + +E+GEL LD+W +++V PL A L ++ + +I
Sbjct: 131 ----DMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREI--KNDRGGEDPNQKVIHGV 184
Query: 231 IQSTVHVRSFRVRSPLALYEQLVLEPFLQAAG 262
I S VHV ++ + PL Y+++ PFL G
Sbjct: 185 INSFVHVEQYKKKFPLKFYQEIFESPFLTETG 216
Score = 32.7 bits (71), Expect = 4.5
Identities = 14/21 (66%), Positives = 15/21 (71%)
Query: 1 MSLKPRHVDFQETWANLKETV 21
MSLKPR VDF ETW L T+
Sbjct: 1 MSLKPRVVDFDETWNKLLTTI 21
>X81882-1|CAA57465.1| 780|Homo sapiens vasopressin activated
calcium mobilizing receptor-like protein protein.
Length = 780
Score = 111 bits (267), Expect = 8e-24
Identities = 66/182 (36%), Positives = 100/182 (54%), Gaps = 19/182 (10%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----------------GE 559
+VE +LTL ++SKL E F F+ A DKA AVVN + +
Sbjct: 340 YVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQ 399
Query: 560 EACRAPELVARYCDWVLRRRPAAAPLT--DVDDKLTAAIVVFKYIDDKDIFQKHYARALA 617
+ PEL+A YCD +LR+ P + LT +++ KL ++V KY+ +KD+F +++ L
Sbjct: 400 PESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLT 459
Query: 618 RRLIHQLSYSMEQEESMINRLK-AACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDL 676
RRLI +S E EE+M+ L+ ++ NKL RMF D+ VS DLN F++ ++N L
Sbjct: 460 RRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKL 519
Query: 677 TL 678
L
Sbjct: 520 AL 521
>BC063306-1|AAH63306.1| 780|Homo sapiens cullin 5 protein.
Length = 780
Score = 111 bits (267), Expect = 8e-24
Identities = 66/182 (36%), Positives = 100/182 (54%), Gaps = 19/182 (10%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----------------GE 559
+VE +LTL ++SKL E F F+ A DKA AVVN + +
Sbjct: 340 YVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQ 399
Query: 560 EACRAPELVARYCDWVLRRRPAAAPLT--DVDDKLTAAIVVFKYIDDKDIFQKHYARALA 617
+ PEL+A YCD +LR+ P + LT +++ KL ++V KY+ +KD+F +++ L
Sbjct: 400 PESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLT 459
Query: 618 RRLIHQLSYSMEQEESMINRLK-AACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDL 676
RRLI +S E EE+M+ L+ ++ NKL RMF D+ VS DLN F++ ++N L
Sbjct: 460 RRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKL 519
Query: 677 TL 678
L
Sbjct: 520 AL 521
>AF327710-1|AAK07472.1| 780|Homo sapiens cullin 5 protein.
Length = 780
Score = 111 bits (267), Expect = 8e-24
Identities = 66/182 (36%), Positives = 100/182 (54%), Gaps = 19/182 (10%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----------------GE 559
+VE +LTL ++SKL E F F+ A DKA AVVN + +
Sbjct: 340 YVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQ 399
Query: 560 EACRAPELVARYCDWVLRRRPAAAPLT--DVDDKLTAAIVVFKYIDDKDIFQKHYARALA 617
+ PEL+A YCD +LR+ P + LT +++ KL ++V KY+ +KD+F +++ L
Sbjct: 400 PESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLT 459
Query: 618 RRLIHQLSYSMEQEESMINRLK-AACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDL 676
RRLI +S E EE+M+ L+ ++ NKL RMF D+ VS DLN F++ ++N L
Sbjct: 460 RRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKL 519
Query: 677 TL 678
L
Sbjct: 520 AL 521
>AF017061-1|AAB70253.1| 781|Homo sapiens vasopressin-activated
calcium mobilizing putative receptor protein protein.
Length = 781
Score = 111 bits (267), Expect = 8e-24
Identities = 66/182 (36%), Positives = 100/182 (54%), Gaps = 19/182 (10%)
Query: 516 FVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRS----------------GE 559
+VE +LTL ++SKL E F F+ A DKA AVVN + +
Sbjct: 341 YVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQ 400
Query: 560 EACRAPELVARYCDWVLRRRPAAAPLT--DVDDKLTAAIVVFKYIDDKDIFQKHYARALA 617
+ PEL+A YCD +LR+ P + LT +++ KL ++V KY+ +KD+F +++ L
Sbjct: 401 PESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLT 460
Query: 618 RRLIHQLSYSMEQEESMINRLK-AACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDL 676
RRLI +S E EE+M+ L+ ++ NKL RMF D+ VS DLN F++ ++N L
Sbjct: 461 RRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKL 520
Query: 677 TL 678
L
Sbjct: 521 AL 522
>BX537787-1|CAD97843.1| 895|Homo sapiens hypothetical protein
protein.
Length = 895
Score = 95.5 bits (227), Expect = 6e-19
Identities = 51/163 (31%), Positives = 93/163 (57%), Gaps = 4/163 (2%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + + F + F+ A+ +A +N R + A EL+A+Y D L
Sbjct: 498 VQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPA----ELIAKYVDSKL 553
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 554 RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 613
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLN 679
+LK CG FT+KL MF D+ +S D+ +F+QY+++ ++ N
Sbjct: 614 KLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN 656
>BC036216-1|AAH36216.1| 913|Homo sapiens cullin 4B protein.
Length = 913
Score = 95.5 bits (227), Expect = 6e-19
Identities = 51/163 (31%), Positives = 93/163 (57%), Gaps = 4/163 (2%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + + F + F+ A+ +A +N R + A EL+A+Y D L
Sbjct: 516 VQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPA----ELIAKYVDSKL 571
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 572 RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 631
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLN 679
+LK CG FT+KL MF D+ +S D+ +F+QY+++ ++ N
Sbjct: 632 KLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN 674
>AY365125-1|AAR13073.1| 895|Homo sapiens cullin 4B protein.
Length = 895
Score = 95.5 bits (227), Expect = 6e-19
Identities = 51/163 (31%), Positives = 93/163 (57%), Gaps = 4/163 (2%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + + F + F+ A+ +A +N R + A EL+A+Y D L
Sbjct: 498 VQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPA----ELIAKYVDSKL 553
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 554 RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 613
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLN 679
+LK CG FT+KL MF D+ +S D+ +F+QY+++ ++ N
Sbjct: 614 KLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN 656
>AL451005-1|CAI41370.1| 913|Homo sapiens cullin 4B protein.
Length = 913
Score = 95.5 bits (227), Expect = 6e-19
Identities = 51/163 (31%), Positives = 93/163 (57%), Gaps = 4/163 (2%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + + F + F+ A+ +A +N R + A EL+A+Y D L
Sbjct: 516 VQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPA----ELIAKYVDSKL 571
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 572 RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 631
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLN 679
+LK CG FT+KL MF D+ +S D+ +F+QY+++ ++ N
Sbjct: 632 KLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN 674
>AC002476-3|AAB67315.1| 652|Homo sapiens WUGSC:H_DJ318C15.2
protein.
Length = 652
Score = 95.5 bits (227), Expect = 6e-19
Identities = 51/163 (31%), Positives = 93/163 (57%), Gaps = 4/163 (2%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + + F + F+ A+ +A +N R + A EL+A+Y D L
Sbjct: 255 VQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPA----ELIAKYVDSKL 310
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 311 RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 370
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLN 679
+LK CG FT+KL MF D+ +S D+ +F+QY+++ ++ N
Sbjct: 371 KLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN 413
>AB014595-1|BAA31670.2| 781|Homo sapiens KIAA0695 protein protein.
Length = 781
Score = 95.5 bits (227), Expect = 6e-19
Identities = 51/163 (31%), Positives = 93/163 (57%), Gaps = 4/163 (2%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + + F + F+ A+ +A +N R + A EL+A+Y D L
Sbjct: 384 VQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPA----ELIAKYVDSKL 439
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 440 RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 499
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLN 679
+LK CG FT+KL MF D+ +S D+ +F+QY+++ ++ N
Sbjct: 500 KLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN 542
>U58089-1|AAC50546.1| 577|Homo sapiens Hs-CUL-3 protein.
Length = 577
Score = 91.5 bits (217), Expect = 9e-18
Identities = 47/165 (28%), Positives = 94/165 (56%), Gaps = 5/165 (3%)
Query: 514 IHFVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCD 573
+ +++ +L L ++ + E F + F + +N S R+PE ++ + D
Sbjct: 148 VDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFID 202
Query: 574 WVLRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEES 633
L++ +V+ L A+V+F+++ +KD+F+++Y + LARRL+ S S + E++
Sbjct: 203 DKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKN 262
Query: 634 MINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
MI++LK CG +FT+KL MF D+++S +F+Q+L+ ++L
Sbjct: 263 MISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSL 307
>BC092409-1|AAH92409.1| 768|Homo sapiens cullin 3 protein.
Length = 768
Score = 91.5 bits (217), Expect = 9e-18
Identities = 47/165 (28%), Positives = 94/165 (56%), Gaps = 5/165 (3%)
Query: 514 IHFVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCD 573
+ +++ +L L ++ + E F + F + +N S R+PE ++ + D
Sbjct: 339 VDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFID 393
Query: 574 WVLRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEES 633
L++ +V+ L A+V+F+++ +KD+F+++Y + LARRL+ S S + E++
Sbjct: 394 DKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKN 453
Query: 634 MINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
MI++LK CG +FT+KL MF D+++S +F+Q+L+ ++L
Sbjct: 454 MISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSL 498
>BC039598-1|AAH39598.1| 768|Homo sapiens cullin 3 protein.
Length = 768
Score = 91.5 bits (217), Expect = 9e-18
Identities = 47/165 (28%), Positives = 94/165 (56%), Gaps = 5/165 (3%)
Query: 514 IHFVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCD 573
+ +++ +L L ++ + E F + F + +N S R+PE ++ + D
Sbjct: 339 VDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFID 393
Query: 574 WVLRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEES 633
L++ +V+ L A+V+F+++ +KD+F+++Y + LARRL+ S S + E++
Sbjct: 394 DKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKN 453
Query: 634 MINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
MI++LK CG +FT+KL MF D+++S +F+Q+L+ ++L
Sbjct: 454 MISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSL 498
>AF064087-1|AAC36304.1| 768|Homo sapiens cullin 3 protein.
Length = 768
Score = 91.5 bits (217), Expect = 9e-18
Identities = 47/165 (28%), Positives = 94/165 (56%), Gaps = 5/165 (3%)
Query: 514 IHFVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCD 573
+ +++ +L L ++ + E F + F + +N S R+PE ++ + D
Sbjct: 339 VDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFID 393
Query: 574 WVLRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEES 633
L++ +V+ L A+V+F+++ +KD+F+++Y + LARRL+ S S + E++
Sbjct: 394 DKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKN 453
Query: 634 MINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
MI++LK CG +FT+KL MF D+++S +F+Q+L+ ++L
Sbjct: 454 MISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSL 498
>AF062537-1|AAC36682.1| 768|Homo sapiens cullin 3 protein.
Length = 768
Score = 91.5 bits (217), Expect = 9e-18
Identities = 47/165 (28%), Positives = 94/165 (56%), Gaps = 5/165 (3%)
Query: 514 IHFVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCD 573
+ +++ +L L ++ + E F + F + +N S R+PE ++ + D
Sbjct: 339 VDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFID 393
Query: 574 WVLRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEES 633
L++ +V+ L A+V+F+++ +KD+F+++Y + LARRL+ S S + E++
Sbjct: 394 DKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKN 453
Query: 634 MINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
MI++LK CG +FT+KL MF D+++S +F+Q+L+ ++L
Sbjct: 454 MISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSL 498
>AC073052-1|AAX93287.1| 746|Homo sapiens unknown protein.
Length = 746
Score = 91.5 bits (217), Expect = 9e-18
Identities = 47/165 (28%), Positives = 94/165 (56%), Gaps = 5/165 (3%)
Query: 514 IHFVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCD 573
+ +++ +L L ++ + E F + F + +N S R+PE ++ + D
Sbjct: 317 VDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFID 371
Query: 574 WVLRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEES 633
L++ +V+ L A+V+F+++ +KD+F+++Y + LARRL+ S S + E++
Sbjct: 372 DKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKN 431
Query: 634 MINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
MI++LK CG +FT+KL MF D+++S +F+Q+L+ ++L
Sbjct: 432 MISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSL 476
>AB014517-1|BAA31592.2| 786|Homo sapiens KIAA0617 protein protein.
Length = 786
Score = 91.5 bits (217), Expect = 9e-18
Identities = 47/165 (28%), Positives = 94/165 (56%), Gaps = 5/165 (3%)
Query: 514 IHFVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCD 573
+ +++ +L L ++ + E F + F + +N S R+PE ++ + D
Sbjct: 357 VDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFID 411
Query: 574 WVLRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEES 633
L++ +V+ L A+V+F+++ +KD+F+++Y + LARRL+ S S + E++
Sbjct: 412 DKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKN 471
Query: 634 MINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
MI++LK CG +FT+KL MF D+++S +F+Q+L+ ++L
Sbjct: 472 MISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSL 516
>AY337761-1|AAQ01660.1| 744|Homo sapiens cullin 3 isoform protein.
Length = 744
Score = 91.1 bits (216), Expect = 1e-17
Identities = 47/165 (28%), Positives = 93/165 (56%), Gaps = 5/165 (3%)
Query: 514 IHFVEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCD 573
+ +++ +L L ++ + E F + F + +N S R+PE ++ + D
Sbjct: 315 VDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFID 369
Query: 574 WVLRRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEES 633
L + +V+ L A+V+F+++ +KD+F+++Y + LARRL+ S S + E++
Sbjct: 370 DKLTKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKN 429
Query: 634 MINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
MI++LK CG +FT+KL MF D+++S +F+Q+L+ ++L
Sbjct: 430 MISKLKTECGCQFTSKLEGMFRDMSISTTTMDEFRQHLQATGVSL 474
>AF212995-1|AAK16812.1| 782|Homo sapiens cullin CUL4B protein.
Length = 782
Score = 90.2 bits (214), Expect = 2e-17
Identities = 51/165 (30%), Positives = 93/165 (56%), Gaps = 6/165 (3%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + + F + F+ A+ +A +N R + A EL+A+Y D L
Sbjct: 383 VQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPA----ELIAKYVDSKL 438
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 439 RAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 498
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQ--YLRDNDLTLN 679
+LK CG FT+KL MF D+ +S D+ +F+Q Y+++ ++ N
Sbjct: 499 KLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQVKYMQNQNVPGN 543
>U58090-1|AAC50547.1| 421|Homo sapiens Hs-CUL-4A protein.
Length = 421
Score = 86.6 bits (205), Expect = 3e-16
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 10/169 (5%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + F + F+ + ++ +N R + A EL+A++ D L
Sbjct: 24 VQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKL 79
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 80 RAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 139
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDN------DLTLN 679
+LK CG FT+KL MF D+ +S D+ F+Q++++ DLT+N
Sbjct: 140 KLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVN 188
>BC008308-1|AAH08308.2| 759|Homo sapiens cullin 4A protein.
Length = 759
Score = 86.6 bits (205), Expect = 3e-16
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 10/169 (5%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + F + F+ + ++ +N R + A EL+A++ D L
Sbjct: 362 VQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKL 417
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 418 RAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 477
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDN------DLTLN 679
+LK CG FT+KL MF D+ +S D+ F+Q++++ DLT+N
Sbjct: 478 KLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVN 526
>AY365124-1|AAR13072.1| 759|Homo sapiens cullin 4A protein.
Length = 759
Score = 86.6 bits (205), Expect = 3e-16
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 10/169 (5%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + F + F+ + ++ +N R + A EL+A++ D L
Sbjct: 362 VQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKL 417
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 418 RAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 477
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDN------DLTLN 679
+LK CG FT+KL MF D+ +S D+ F+Q++++ DLT+N
Sbjct: 478 KLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVN 526
>AL136221-5|CAI13795.1| 659|Homo sapiens cullin 4A protein.
Length = 659
Score = 86.6 bits (205), Expect = 3e-16
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 10/169 (5%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + F + F+ + ++ +N R + A EL+A++ D L
Sbjct: 262 VQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKL 317
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 318 RAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 377
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDN------DLTLN 679
+LK CG FT+KL MF D+ +S D+ F+Q++++ DLT+N
Sbjct: 378 KLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVN 426
>AL136221-4|CAM18410.1| 759|Homo sapiens cullin 4A protein.
Length = 759
Score = 86.6 bits (205), Expect = 3e-16
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 10/169 (5%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + F + F+ + ++ +N R + A EL+A++ D L
Sbjct: 362 VQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKL 417
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 418 RAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 477
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDN------DLTLN 679
+LK CG FT+KL MF D+ +S D+ F+Q++++ DLT+N
Sbjct: 478 KLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVN 526
>AF077188-1|AAD45191.1| 659|Homo sapiens cullin 4A protein.
Length = 659
Score = 86.6 bits (205), Expect = 3e-16
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 10/169 (5%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + F + F+ + ++ +N R + A EL+A++ D L
Sbjct: 262 VQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKL 317
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 318 RAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 377
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDN------DLTLN 679
+LK CG FT+KL MF D+ +S D+ F+Q++++ DLT+N
Sbjct: 378 KLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVN 426
>AB178950-1|BAD93235.1| 759|Homo sapiens cullin-4A protein.
Length = 759
Score = 86.6 bits (205), Expect = 3e-16
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 10/169 (5%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + F + F+ + ++ +N R + A EL+A++ D L
Sbjct: 362 VQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKL 417
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 418 RAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 477
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDN------DLTLN 679
+LK CG FT+KL MF D+ +S D+ F+Q++++ DLT+N
Sbjct: 478 KLKHECGAAFTSKLEGMFRDMELSKDIMVHFKQHMQNQSDSGPIDLTVN 526
>AB012193-1|BAA33146.1| 524|Homo sapiens cullin-4A protein.
Length = 524
Score = 86.6 bits (205), Expect = 3e-16
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 10/169 (5%)
Query: 517 VEAILTLHGKYSKLFNEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVL 576
V+ +L K + F + F+ + ++ +N R + A EL+A++ D L
Sbjct: 127 VQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKL 182
Query: 577 RRRPAAAPLTDVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMIN 636
R A +++ L +++F++I KD+F+ Y + LA+RL+ S S++ E+SM++
Sbjct: 183 RAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS 242
Query: 637 RLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDN------DLTLN 679
+LK CG FT+KL MF D+ +S D+ F+Q++++ DLT+N
Sbjct: 243 KLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVN 291
>BC031844-1|AAH31844.1| 373|Homo sapiens CUL3 protein protein.
Length = 373
Score = 79.8 bits (188), Expect = 3e-14
Identities = 35/92 (38%), Positives = 65/92 (70%)
Query: 587 DVDDKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEF 646
+V+ L A+V+F+++ +KD+F+++Y + LARRL+ S S + E++MI++LK CG +F
Sbjct: 12 EVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQF 71
Query: 647 TNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
T+KL MF D+++S +F+Q+L+ ++L
Sbjct: 72 TSKLEGMFRDMSISNTTMDEFRQHLQATGVSL 103
>U58091-1|AAC50548.1| 288|Homo sapiens Hs-CUL-4B protein.
Length = 288
Score = 48.0 bits (109), Expect = 1e-04
Identities = 20/49 (40%), Positives = 35/49 (71%)
Query: 631 EESMINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTLN 679
E+SM+++LK CG FT+KL MF D+ +S D+ +F+QY+++ ++ N
Sbjct: 1 EKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN 49
>AF052147-1|AAC28621.1| 343|Homo sapiens cul-3 protein.
Length = 343
Score = 44.4 bits (100), Expect = 0.001
Identities = 19/53 (35%), Positives = 36/53 (67%)
Query: 626 YSMEQEESMINRLKAACGYEFTNKLHRMFTDVAVSADLNAKFQQYLRDNDLTL 678
+ M +++MI++LK CG +FT+KL MF D+++S +F+Q+L+ ++L
Sbjct: 21 FLMTLKKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSL 73
>BC032503-1|AAH32503.1| 822|Homo sapiens anaphase promoting complex
subunit 2 protein.
Length = 822
Score = 40.3 bits (90), Expect = 0.022
Identities = 23/65 (35%), Positives = 33/65 (50%)
Query: 605 KDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEFTNKLHRMFTDVAVSADLN 664
KD+F Y LA RL+HQ S+S E+E + LK G + M D+A S +N
Sbjct: 512 KDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRIN 571
Query: 665 AKFQQ 669
A ++
Sbjct: 572 ANIRE 576
>BC001579-1|AAH01579.1| 577|Homo sapiens ANAPC2 protein protein.
Length = 577
Score = 40.3 bits (90), Expect = 0.022
Identities = 23/65 (35%), Positives = 33/65 (50%)
Query: 605 KDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEFTNKLHRMFTDVAVSADLN 664
KD+F Y LA RL+HQ S+S E+E + LK G + M D+A S +N
Sbjct: 267 KDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRIN 326
Query: 665 AKFQQ 669
A ++
Sbjct: 327 ANIRE 331
>AL929554-12|CAH72881.1| 822|Homo sapiens anaphase promoting
complex subunit 2 protein.
Length = 822
Score = 40.3 bits (90), Expect = 0.022
Identities = 23/65 (35%), Positives = 33/65 (50%)
Query: 605 KDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEFTNKLHRMFTDVAVSADLN 664
KD+F Y LA RL+HQ S+S E+E + LK G + M D+A S +N
Sbjct: 512 KDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRIN 571
Query: 665 AKFQQ 669
A ++
Sbjct: 572 ANIRE 576
>AF191337-1|AAF05751.1| 822|Homo sapiens anaphase-promoting complex
subunit 2 protein.
Length = 822
Score = 40.3 bits (90), Expect = 0.022
Identities = 23/65 (35%), Positives = 33/65 (50%)
Query: 605 KDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEFTNKLHRMFTDVAVSADLN 664
KD+F Y LA RL+HQ S+S E+E + LK G + M D+A S +N
Sbjct: 512 KDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRIN 571
Query: 665 AKFQQ 669
A ++
Sbjct: 572 ANIRE 576
>AB037827-1|BAA92644.1| 571|Homo sapiens KIAA1406 protein protein.
Length = 571
Score = 40.3 bits (90), Expect = 0.022
Identities = 23/65 (35%), Positives = 33/65 (50%)
Query: 605 KDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEFTNKLHRMFTDVAVSADLN 664
KD+F Y LA RL+HQ S+S E+E + LK G + M D+A S +N
Sbjct: 261 KDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRIN 320
Query: 665 AKFQQ 669
A ++
Sbjct: 321 ANIRE 325
>D38548-1|BAA07551.2| 1701|Homo sapiens KIAA0076 protein.
Length = 1701
Score = 33.5 bits (73), Expect = 2.6
Identities = 33/144 (22%), Positives = 67/144 (46%), Gaps = 11/144 (7%)
Query: 532 NEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVLR--RRPAAAPLTDVD 589
+E+FG AF+ AL C+ + +A E AR+ D ++ R A + +
Sbjct: 1187 SELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLA 1246
Query: 590 --DKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEFT 647
+ A+++F ++ F+ +Y +A RL+ +S + E +++ ++ G F
Sbjct: 1247 QLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWL--EGAVLEQI----GPCFP 1300
Query: 648 NKL-HRMFTDVAVSADLNAKFQQY 670
N+L +M ++ S +L +F Y
Sbjct: 1301 NRLPQQMLQSLSTSKELQRQFHVY 1324
>BC033647-1|AAH33647.1| 1698|Homo sapiens cullin 7 protein.
Length = 1698
Score = 33.5 bits (73), Expect = 2.6
Identities = 33/144 (22%), Positives = 67/144 (46%), Gaps = 11/144 (7%)
Query: 532 NEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVLR--RRPAAAPLTDVD 589
+E+FG AF+ AL C+ + +A E AR+ D ++ R A + +
Sbjct: 1184 SELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLA 1243
Query: 590 --DKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEFT 647
+ A+++F ++ F+ +Y +A RL+ +S + E +++ ++ G F
Sbjct: 1244 QLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWL--EGAVLEQI----GPCFP 1297
Query: 648 NKL-HRMFTDVAVSADLNAKFQQY 670
N+L +M ++ S +L +F Y
Sbjct: 1298 NRLPQQMLQSLSTSKELQRQFHVY 1321
>AL355385-1|CAI13779.1| 1698|Homo sapiens cullin 7 protein.
Length = 1698
Score = 33.5 bits (73), Expect = 2.6
Identities = 33/144 (22%), Positives = 67/144 (46%), Gaps = 11/144 (7%)
Query: 532 NEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVLR--RRPAAAPLTDVD 589
+E+FG AF+ AL C+ + +A E AR+ D ++ R A + +
Sbjct: 1184 SELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLA 1243
Query: 590 --DKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEFT 647
+ A+++F ++ F+ +Y +A RL+ +S + E +++ ++ G F
Sbjct: 1244 QLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWL--EGAVLEQI----GPCFP 1297
Query: 648 NKL-HRMFTDVAVSADLNAKFQQY 670
N+L +M ++ S +L +F Y
Sbjct: 1298 NRLPQQMLQSLSTSKELQRQFHVY 1321
>AL136304-2|CAI19793.1| 1698|Homo sapiens cullin 7 protein.
Length = 1698
Score = 33.5 bits (73), Expect = 2.6
Identities = 33/144 (22%), Positives = 67/144 (46%), Gaps = 11/144 (7%)
Query: 532 NEVFGGAQAFMGALDKACSAVVNSRSGEEACRAPELVARYCDWVLR--RRPAAAPLTDVD 589
+E+FG AF+ AL C+ + +A E AR+ D ++ R A + +
Sbjct: 1184 SELFGPRAAFLLALQNGCAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLA 1243
Query: 590 --DKLTAAIVVFKYIDDKDIFQKHYARALARRLIHQLSYSMEQEESMINRLKAACGYEFT 647
+ A+++F ++ F+ +Y +A RL+ +S + E +++ ++ G F
Sbjct: 1244 QLQQCLQAVLIFSGLEIATTFEHYYQHYMADRLLGVVSSWL--EGAVLEQI----GPCFP 1297
Query: 648 NKL-HRMFTDVAVSADLNAKFQQY 670
N+L +M ++ S +L +F Y
Sbjct: 1298 NRLPQQMLQSLSTSKELQRQFHVY 1321
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.133 0.390
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 81,152,118
Number of Sequences: 224733
Number of extensions: 2907833
Number of successful extensions: 4863
Number of sequences better than 10.0: 54
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 4704
Number of HSP's gapped (non-prelim): 125
length of query: 691
length of database: 73,234,838
effective HSP length: 95
effective length of query: 596
effective length of database: 51,885,203
effective search space: 30923580988
effective search space used: 30923580988
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 69 (31.9 bits)
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